最新美国发明专利第2025-02-18期 - 专利汇|PatentHub专利检索|专利查询网|发明专利查询分析

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US12227870B2	Fused quartz crucible for producing silicon crystals, and method for producing a fused quartz crucible A fused quartz crucible for pulling a single crystal of silicon by the Czochralski technique, has an inner side with an inner layer of fused quartz that forms a surface, the inner layer being provided with a crystallization promoter which on heating of the fused quartz crucible during use, in crystal pulling, causes crystallization of fused quartz to form b-cristobalite, wherein the concentration C of synthetically obtained SiO2 at a distance d from the surface is greater than the concentration of synthetically obtained SiO2 at a distance d2 from the surface, where d2 is greater than d. Multiple crystals can be grown while maintaining high crystal quality.
US12227866B2	Systems and methods for electrochemical process The present disclosure is related to systems and methods for electrochemical process. The system may include a first electrode, a second electrode, an electric field distribution simulation optimizer, an electric field distribution controller, and a signal controller. The first electrode and the second electrode may form an electric field to change a substance on the second electrode. A morphology of the second electrode may be uneven. The first electrode may include an electrically conducting plate. A morphology of the electrically conducting plate may be in conformity with the morphology of the second electrode. A protruding portion of the electrically conducting plate may correspond to a recessing portion of the second electrode. A recessing portion of the electrically conducting plate may correspond to a protruding portion of the second electrode. The electric field distribution controller may be electrically connected to the signal controller and the electric field distribution simulation optimizer, respectively. The signal controller may be electrically connected to the electrically conducting plate. The signal controller may be configured to apply a processing signal to the electrically conducting plate.
US12227864B2	Additive compound for uniform dyeing after anodic oxidation, additive solution having the additive compound, and dyeing method An additive compound for dyeing an aluminum or aluminum alloy substrate after anodic oxidation to provide better uniformity in dyeing and hence a better finished appearance includes a main agent, an auxiliary agent, a pH stabilizer, and an antibacterial agent. The antibacterial agent includes at least one of sorbic acid, fluconazole, itraconazole, Artemisia argyi, benzyl alcohol, benzoic acid, salicylic acid, and boric acid. An additive solution and a dyeing method are also provided, the use of the compound also allows for a more rapid dyeing process.
US12227853B2	Thermal spray iron-based alloys for coating engine cylinder bores Disclosed herein are embodiments of iron-based alloys. The alloys can be powders used as a feedstock for plasma or thermal spray processes. In some embodiments, the alloys can have low or no chromium, provided improvements from an environmental and worker health perspective. In some embodiments, the powder can have a generally large particle size.
US12227849B2	Copper-fouling-resistant stator water cooling (SWC) system and method Described herein is a stator water cooling (SWC) system in an electrical power generator with improved resistance to copper fouling, more specifically, to a component of the SWC system, such as a strainer, having an anti-fouling metallic material on the surface of the component. Also described herein is a method of reducing copper fouling in a SWC system that comprises applying an anti-fouling metallic material to the surface of a SWC system component.
US12227842B2	Vapor accumulator for corrosive gases with purging Vapor accumulator reservoirs for semiconductor processing operations, such as atomic layer deposition operations, are provided. Such vapor accumulator reservoirs may include a perimeter plenum volume filled with an inert gas, which may reduce or prevent the leakage of external contaminants into a process gas. In some implementations, the reservoir may be constructed from corrosion-resistant materials to reduce internal contaminants into the process gas.
US12227839B2	Sealing article comprising metal coating, method of making and method of using the same A sealing article includes a body and a coating layer disposed on at least one surface of the body. The body comprises a polymeric elastomer such as perfluoroelastomer or fluoroelastomer. The coating layer comprises at least one metal. The sealing article may be a seal, a gasket, an O-ring, a T-ring or any other suitable product. The sealing article is resistant to ultra-violet (UV) light and plasma, and may be used for sealing a semiconductor processing chamber.
US12227836B2	Cutting tool Provided is a cutting tool including a base material and a coating layer provided on the base material, the coating layer including a titanium carbonitride layer provided on the base material, an intermediate layer provided on the titanium carbonitride layer in contact therewith, and an alumina layer provided on the intermediate layer in contact therewith, the intermediate layer being composed of a compound made of titanium, carbon, oxygen, and nitrogen, the intermediate layer having a thickness of more than 1 μm, when PC1 atomic % represents an atomic ratio of the carbon in an interface between the intermediate layer and the alumina layer, and PC2 atomic % represents an atomic ratio of the carbon at a point A away from the interface by 1 μm on a side of the intermediate layer, a ratio PC1/PC2 of the PC1 to the PC2 being more than or equal to 1.03.
US12227829B2	High-temperature component A high-temperature component made of a refractory metal or a refractory metal alloy, includes a coating for increasing thermal emissivity. The coating is formed substantially of tungsten and rhenium, i.e. of at least 55 wt. % rhenium and at least 10 wt. % tungsten, and has a Re3W phase of at least 35 wt. %. A process for producing a high-temperature component having a coating for increasing thermal emissivity, is also provided.
US12227825B2	Stainless steel powders for additive manufacturing Exemplary alloys may be particularly suited for additive manufacturing applications, and may comprise iron and one or more of: chromium (Cr), nickel (Ni), carbon (C), and copper (Cu). Exemplary alloys may have a majority microstructure that is martensite.
US12227823B2	Metal plate for producing vapor deposition masks, production method for metal plates, vapor deposition mask, production method for vapor deposition mask, and vapor deposition mask device comprising vapor deposition mask A metal plate used for manufacturing a deposition mask has a thickness of equal to or less than 30 μm. An average cross-sectional area of the crystals grains on a cross section of the metal plate is from 0.5 μm2 to 50 μm2. The average cross-sectional area of crystal grains is calculated by analyzing measurement results obtained by an EBSD method, the measuring results being analyzed by an area method under conditions where a portion with a difference in crystal orientation of 5 degrees or more is recognized as a crystal grain boundary.
US12227822B2	Hot-dip coated steel substrate A hot-dip coated steel substrate coated with a layer of Sn directly topped by a zinc or an aluminum based coating is provided, the steel substrate having the following chemical composition in weight percent: 0.10≤C≤0.4%, 1.2≤Mn≤6.0%, 0.3≤Si≤2.5%, Al<2.0%, and on a purely optional basis, one or more elements such as P<0.1%, Nb ≤0.5%, B≤ 0.005%, Cr≤1.0%, Mo≤0.50%, Ni≤1.0%, Ti≤0.5%, the remainder of the composition making up of iron and inevitable impurities resulting from the elaboration, the steel substrate further having between 0.0001 and 0.01% by weight of Sn in the region extending from the steel substrate surface up to 10 μm.
US12227820B2	Method and device for producing direct reduced metal A method for producing direct reduced metal material includes charging metal material to be reduced into a furnace space; evacuating an existing atmosphere from the furnace space so as to achieve an underpressure inside the furnace space; providing, in a main heating step, heat and hydrogen gas to the furnace space, so that heated hydrogen gas heats the charged metal material to a temperature high enough so that metal oxides present in the metal material are reduced, in turn causing water vapor to be formed; and condensing and collecting the water vapor in a condenser below the charged metal material. The providing of heat and hydrogen gas, and the condensing and collecting, are performed at least until a hydrogen atmosphere overpressure has been reached inside the furnace space, and so that no hydrogen gas is evacuated from the furnace space until the overpressure has been reached.
US12227811B2	Primer group for simultaneous detection of 15 porcine pathogens through high-throughput targeted amplicon sequencing and use thereof A primer group for simultaneous detection of 15 porcine pathogens through high-throughput targeted amplicon sequencing and use thereof are provided. The primer group for simultaneous detection of 15 porcine pathogens through high-throughput targeted amplicon sequencing includes: primers having nucleotide sequences set forth in SEQ ID NO: 1 to SEQ ID NO: 302. The nucleotide sequences of pathogenic target genes are set forth in SEQ ID NO: 303 to SEQ ID NO: 344. The primer group of the present invention is used for amplicon sequencing detection analysis method for 42 target genes of 15 porcine respiratory pathogens, has the technical advantages of rapidness, high efficiency, high targeting, strong specificity, and the like, and is suitable for rapid and accurate simultaneous diagnosis of multiple pathogens of diseased pigs in pig farms.
US12227810B2	Methods and compositions for detecting esophageal neoplasias and/or metaplasias in the esophagus The disclosure provides methods for identifying genomic loci (e.g., vimentin and/or SqBE18) that are differentially methylated in metaplasias (e.g., Barrett's esophagus) and/or neoplastic cancers (e.g., esophageal cancers). Identification of methylated genomic loci has numerous uses, including for example, to characterize disease risk, to predict responsiveness to therapy, to non-invasively diagnose subjects and to treat subjects determined to have gastrointestinal metaplasias and/or neoplasias.
US12227806B2	Methods for detecting an increased risk for coronary heart disease The invention relates generally to an allele on human chromosome 9 associated with increased risk for coronary heart disease and the use or detection of such an allele in determining whether a human has an increased risk for coronary heart disease. In one aspect, the invention relates to methods for detecting a predisposition or propensity or susceptibility for coronary heart disease in a human, comprising detecting the presence of an allele on human chromosome 9 that is associated with an increased risk for coronary heart disease in a human. Disclosed are methods and compositions for determining whether a person carries an allele associated with increased risk for coronary atherosclerosis by determining whether the person has an RA-CHR9 allele, such as by determining whether the person has an RA-CHR9 allele-associated single nucleotide polymorphism (SNP). The invention also relates to kits for detecting the presence of an allele on chromosome 9 associated with an increased risk for coronary heart disease.
US12227805B2	Genetic test for liver copper accumulation in dogs The present disclosure provides methods of determining the susceptibility of a dog to liver copper accumulation, comprising detecting in a biological sample obtained from the dog the presence or absence in the genome of the dog of one or more polymorphisms, and methods of treating or breeding the dog based on such determination.
US12227800B2	Mutant pores The invention relates to mutant forms of CsgG. The invention also relates to analyte detection and characterisation using CsgG.
US12227797B2	Spatial analysis of a planar biological sample Provided herein, among other things, is method for analyzing a planar biological sample. In some embodiments, the method may comprise: contacting an oligonucleotide or a conjugate comprising the same with a planar biological sample under conditions by which the oligonucleotide or conjugate specifically binds to sites in or on the sample; performing one or more steps to release and/or extend the oligonucleotide in situ, to produce a reporter probe; transferring the reporter probe from the sample to a planar support that does not comprise an array of oligonucleotides, in a way that preserves the spatial relationship of the reporter probe in the sample; and detecting the reporter probe on the support.
US12227796B2	RNA templated ligation The present application provides methods for detecting a target nucleic acid molecule in a sample comprising contacting said sample with a ligatable probe comprising one or more parts and allowing said probe to hybridise to the target nucleic acid molecule, ligating any probe which has hybridised to the target nucleic acid molecule, amplifying the ligated probe, and detecting the amplification product, thereby to detect the target nucleic acid molecule, wherein said probes comprise at least one ribonucleotide at or near to a ligation site and/or wherein the probe or a probe part comprises an additional sequence 5′ to a target-specific binding site which is not hybridised to the target nucleic acid molecule upon hybridisation of the probe to the target nucleic acid molecule and forms a 5′ flap containing one or more nucleotides at its 3′ end that is cleaved prior to ligation, and methods of synthesising a DNA molecule with Phi29 DNA polymerase using a template nucleic acid molecule comprising at least one ribonucleotide. Probes for use in the detection methods are provided.
US12227790B2	Solid phase extraction material and its use for nucleic acid enrichment and detection A method of enriching nucleic acid, including mixing a sample with a solid phase extraction material; and separating the solid phase extraction material; wherein the solid phase extraction material is glass beads or magnetic beads modified with reduced graphene oxide. Also disclosed is a method of detecting nucleic acid, including mixing a nucleic acid sample enriched by the method above with a probe; and amplifying and detecting an amplification product by electrophoresis.
US12227788B2	Compositions, methods and treatments for inhibiting cell adhesion and virus binding and penetration Disclosed herein are glyco-decoy acceptor compositions that sidetrack or inhibit the activity of biosynthetic enzymes participating in synthesis of ligands binding at selectin, galectin and siglecs receptors; methods of their preparation and uses in drug discovery and in treatments of diseases.
US12227787B2	Method of evaluating quality of dephosphorylation reagent and method of detecting target nucleic acid A method evaluates a quality of a dephosphorylation reagent, the method including the steps of: providing a dephosphorylation reagent containing an alkaline phosphatase and a peptide fragment derived from the alkaline phosphatase; and evaluating the dephosphorylation reagent as having a high quality if a content ratio of the peptide fragment to the alkaline phosphatase is a predetermined reference value or less.
US12227784B2	Enzyme blends and processes for improving the nutritional quality of animal feed The present invention relates to a process for improving the nutritional quality of distillers dried grains (DGS) or distillers dried grains with solubles (DDGS) produced as a co-product of a fermentation product production process, processes for producing fermentation products, as well as enzyme blends used in the processes.
US12227782B2	Method for producing protein Provided is an inexpensive and efficient microbiological method for producing a protein. The method for producing a protein comprises culturing a microorganism in the presence of glycosylamine.
US12227780B2	Isothiocyanate containing Brassicaceae products and method of preparation thereof The present invention relates to methods for producing isothiocyanate containing products from Brassicaceae material and lactic acid bacteria for use in such methods. The present invention also relates to isothiocyanate containing products from Brassicaceae material produced by such methods.
US12227777B2	Soluble alpha-Klotho proteins, protein fragments, and uses thereof Disclosed herein are modified soluble α-Klotho proteins and isolated fragments of wildtype soluble α-Klotho protein. Also disclosed are pharmaceutical compositions including the modified soluble α-Klotho proteins and/or isolated fragments of soluble α-Klotho protein and methods of their use in treating a subject.
US12227773B2	Recombinase polymerase amplification The present invention features novel, diverse, hybrid and engineered recombinase enzymes, and the utility of such proteins with associated recombination factors for carrying out DNA amplification assays. The present invention also features different recombinase ‘systems’ having distinct biochemical activities in DNA amplification assays, and differing requirements for loading factors, single-stranded DNA binding proteins (SSBs), and the quantity of crowding agent employed.
US12227771B2	Expression systems and methods of use thereof Expression systems for the expression of an α9α10 nicotinic acetylcholine receptor (nAChR) are described. Also described are methods of using the expression systems to identify agonists, antagonists, or allosteric modulators of an α9α10 nAChR.
US12227770B2	Alphavirus replicon particle Provided is an alphavirus replicon particle (ARP), which comprises (i) alphavirus structural proteins comprising capsid and/or envelope, and (ii) an alphavirus replicon comprising a polynucleotide encoding alphavirus non-structural proteins nsp1, nsp2, nsp3 and nap4 and at least one gene of interest wherein at least one of capsid, and E3 and E2 in the envelope comprise one or more amino acid alteration but E1 in the envelope comprises no amino acid alteration.
US12227768B2	Methods and products for transfection The present invention relates in part to methods for producing tissue-specific cells from patient samples, and to tissue-specific cells produced using these methods. Methods for reprogramming cells using RNA are disclosed. Therapeutics comprising cells produced using these methods are also disclosed.
US12227767B2	Delta133P53Beta and Delta133P53Gamma isoforms are biomarkers of cancer stem cells The present invention is in the field of oncology, and more particularly of cancer stem cells. It relates to a method for producing cancer stem cells based on overexpression of Δ133p53β isoform, Δ133p53γ isoform, or both Δ133p53β and Δ133p53γ isoforms; a method for predicting the risk that treatment with a chemotherapeutic anti-cancer agent induces cancer stem cells in a subject suffering from cancer from a cancer sample of said subject, based on detection of an increase in Δ133p53β isoform, Δ133p53γ isoform, or both Δ133p53β and Δ133p53γ isoforms following chemotherapeutic anti-cancer treatment; to therapeutic uses of a combination of chemotherapeutic anti-cancer agent and an agent reducing Δ133p53β isoform, Δ133p53γ isoform, or both Δ133p53β and Δ133p53γ isoforms expression; and also to screening methods for anti-cancer stem cells agents.
US12227758B2	Somatic haploid human cell line The invention provides for a somatic fully haploid, karyotypically stable human cell line, e.g. obtainable by targeted deletion of one or more disomic chromosomal regions of a somatic near-haploid human parental cell, a method of producing the same, as well as the use of the cell line for producing isogenic cell variants, comprising genomic mutations at different genomic target sites, and a library of such cell variants.
US12227751B2	Nucleotide sequences and corresponding polypeptides conferring improved nitrogen use efficiency characteristics in plants Methods and materials for modulating low-nitrogen tolerance levels in plants are disclosed. For example, nucleic acids encoding low nitrogen tolerance-modulating polypeptides are disclosed as well as methods for using such nucleic acids to transform plant cells. Also disclosed are plants having increased low-nitrogen tolerance levels and plant products produced from plants having increased low-nitrogen tolerance levels.
US12227750B2	Recombinant micelle and method of in vivo assembly A method of in vivo assembly of a recombinant micelle including: introducing a plasmid into a plant cell, wherein: the plasmid includes a segment of deoxyribonucleic acid (DNA) for encoding a ribonucleic acid (RNA) for a protein in a casein micelle, the segment of DNA is transcribed and translated; forming recombinant casein proteins in the plant cell, wherein: the recombinant casein proteins include a κ-casein and at least one of an αS1-casein, an αS2-casein, a β-casein; and assembling in vivo a recombinant micelle within the plant cell, wherein: an outer layer of the recombinant micelle is enriched with the κ-casein, an inner matrix of the recombinant micelle include at least one of the αS1-casein, the αS2-casein, the β-casein.
US12227749B2	Constructs for continuous monitoring of live cells The present invention provides for methods to obtain multiple information-rich samples at different time points from the same cell while minimally disrupting the cell. The subject matter disclosed herein is generally related to nucleic acid constructs for continuous monitoring of live cells. Specifically, the subject matter disclosed herein is directed to nucleic acid constructs that encode a fusion protein and a construct RNA sequence that induce live cells to self-report cellular contents while maintaining cell viability. The present invention may be used to monitor gene expression in single cells while maintaining cell viability.
US12227748B1	Aptamers for binding to a membrane-based lipid A lipid-binding drug for binding to a membrane-based or membrane lipid comprises at least one aptamer having a sequence selected from the group consisting of GGCGGCAAAAAAAAAA (SEQ ID NO: 1), GGCGGCAAAAAAAAAAA (SEQ ID NO: 2), GGCGGCAAAAAAAAAAAA (SEQ ID NO: 3), GGCGGCAAAAAAAAAAAAA (SEQ ID NO: 4), GGCGGCGGGGGGGGGG (SEQ ID NO: 5), GGCGGCGGGGGGGGGGG (SEQ ID NO: 6), GGCGGCGGGGGGGGGGG (SEQ ID NO: 7), GGCGGCGGGGGGGGGGG (SEQ ID NO: 8), CAAAAGGAGCAAAAAAAAAAAAAAAAAAAAAAA (SEQ ID NO: 9) CAAAAGGAGCAAAAAAAAAAAAAAAAAAAAAAAA (SEQ ID NO: 10), CAAAAGGAGCAAAAAAAAAAAAAAAAAAAAAAAAA (SEQ ID NO: 11), CAAAAGGAGCAAAAAAAAAAAAAAAAAAAAAAAAAA (SEQ ID NO: 12), CAAAAGGAGCGGGGGGGGGGGGGGGGGGGGGGG (SEQ ID NO: 13), CAAAAGGAGCGGGGGGGGGGGGGGGGGGGGGGGG (SEQ ID NO: 14), CAAAAGGAGCGGGGGGGGGGGGGGGGGGGGGGGGG (SEQ ID NO: 15), and CAAAAGGAGCGGGGGGGGGGGGGGGGGGGGGGGGGG (SEQ ID NO: 16).
US12227743B2	Pharmaceutical composition for treatment of diseases associated with upregulated periostin expression or periostin splice variant switching Provided is a pharmaceutical composition for the treatment of a disease associated with upregulated periostin expression or periostin splice variant switching, which pharmaceutical composition comprises, as an active ingredient, a nucleic acid capable of inducing skipping of exon 17 in periostin gene transcription and/or a nucleic acid capable of inducing skipping of exon 21 in periostin gene transcription. The pharmaceutical composition of the present invention can treat a disease associated with upregulated periostin expression or periostin splice variant switching, while preventing complete inhibition of the functions of periostin.
US12227739B2	Device for facilitating the isolation of targets from a biological sample A method and a device are provided for facilitating the disaggregation of a plurality of solid phase substrate as the plurality of solid phase substrate are transferred from a first location to a second location. A plurality of solid phase substrate are deposited at the first location and a plurality of particles are added to the plurality of solid phase substrate. A force is generated to draw the plurality of solid phase substrate from the first location to a second location. The plurality of particles causes clumps of the plurality of solid phase substrate to break apart as the plurality of solid phase substrate are moved in response to the force.
US12227737B2	Cancer detection and classification using methylome analysis There is described herein, a method of capturing cell-free methylated DNA from a sample having less than 100 mg of cell-free DNA, comprising the steps of: subjecting the sample to library preparation to permit subsequent sequencing of the cell-free methylated DNA; adding a first amount of filler DNA to the sample, wherein at least a portion of the filler DNA is methylated; denaturing the sample; and capturing cell-free methylated DNA using a binder selective for methylated polynucleotides.
US12227729B2	Methods and systems for high-throughput cell processing Described herein are methods and systems for cell processing or, more specifically, for introducing various payloads into cells. These methods and systems use a mechanoporation approach in which cells are rapidly compressed and then released to relax while absorbing the payload. More specifically, these methods and systems enable high-throughput mechanoporation with various clogging mitigation features. A cell processing apparatus comprises a shell with an inner shell cylindrical surface, a core with an outer core cylindrical surface, and ridges, supported on and protruding away from one of the inner shell cylindrical surface and the outer core cylindrical surface. The core is disposed inside the shell. The outer core cylindrical surface is concentric with the inner shell cylindrical surface. Each of the ridges forms a ridge gap with the other one of the inner shell cylindrical surface and the outer core cylindrical surface.
US12227726B2	Multigel tumor-on-a-chip system Described herein are apparati and methods for growing cells in a manner that mimics the native three-dimensional environment. Cell cultures grown in the apparatus can be screened for inhibition by specific chemotherapeutics or other drugs.
US12227725B2	Cell culturing method and device A cell culturing method and device that uses a cell culture bag (1) that includes a bag body (2) configured from an upper surface film (21) and a lower surface film (22) having a sealed periphery, and a port (3) attached to the bag body (2), and a plurality of recesses (4) being formed in the lower surface film (22). The method including: a closing-off step for closing off the plurality of recesses (4) using the upper surface film (21) by discharging a culture medium (S) contained in the bag body (2) through the port (3); and a releasing step for releasing, in some or all of the plurality of closed-off recesses (4), cells or cell aggregates adhering to the inner surfaces of the recesses (4).
US12227717B2	Pressed manual dish detergent A solid block detergent composition is described which can be dispensed with a water spray to form an aqueous detergent for cutting and removing grease, removing and suspending soils and rinsing easily leaving cleaned ware. The solid block detergent contains a neutralized sulfonated anionic surfactant in combination with various processing aids to optimize soil removal in a formulation that can be pressed for form a solid.
US12227712B2	Refrigerating machine oil, working fluid composition for refrigerating machine, lubricating method, and method for producing refrigerating machine oil A refrigerating machine oil containing: a lubricating base oil; and a polymer additive, wherein a carbon residue of 10% residual oil is 0.05% by mass or more.
US12227703B2	Foaming system for efficient plasma processing of heavy hydrocarbon An apparatus for converting heavy hydrocarbons to light hydrocarbons includes an inlet capable of supplying a pre-foaming mixture comprising a hydrocarbon to be processed and a processing gas, wherein the processing gas is dissolved in the hydrocarbon to be processed; a foam generator configured to receive the pre-foaming mixture at a first pressure, compress the pre-foaming mixture to a second pressure that is higher than the first pressure by routing it through a nozzle; and generate a foam by allowing the pre-foaming mixture at the second pressure to expand in a chamber at a third pressure that is lower than the first or second pressures; a plasma reactor, wherein the plasma reactor is capable of receiving the foam and comprises at least one pair of spark gap electrodes capable of subjecting the foam to a plasma discharge to yield a processed mixture; and an outlet capable of receiving the processed mixture.
US12227702B2	Method for conducting finishing hydrodesulphurisation in the presence of a catalyst on a meso-macroporous support Method for treating a partially desulphurised sulphur-containing hydrocarbon feedstock from a preliminary hydrodesulphurisation step in the presence of a catalyst comprising an active phase comprising a group VII metal and a mesoporous and macroporous alumina support comprising a bimodal distribution of mesopores, wherein: —the volume of mesopores having a diameter greater than or equal to 2 nm and less than 18 nm is between 10 and 30% by volume of the total pore volume of the support; —the volume of mesopores having a diameter greater than or equal to 18 nm and less than 50 nm is between 30 and 50% by volume of the total pore volume of the support; —the volume of macropores having a diameter greater than or equal to 50 nm and less than 8000 nm is between 30 and 50% by volume of the total pore volume of the support.
US12227695B2	Glycosyl hydrolase enzymes in high temperature industrial processes Novel hyperthermophilic Dictyoglomus beta-mannanases are provided for use in high temperature industrial applications requiring enzymatic hydrolysis of 1,4-β-D-mannosidic linkages in mannans, galactomannans, and glucomannans. Also provided are methods and compositions for fracturing a subterranean formation in which a gellable fracturing fluid is first formed by blending together a hydratable polymer and a Dictyoglomus beta-mannanase as an enzyme breaker. An optimized and stabilized recombinant Dictyoglomus beta-mannanase is provided that shows superior performance/effectiveness and properties in degrading guar and derivatized guars at pH ranges from 3.0 to 12 and temperatures ranging from 130° F. to in excess of 270° F.
US12227693B2	Aqueous fluid compositions and barite scale removal therewith Barite (barium sulfate) scale may be problematic in subterranean formations, wellbores, pipelines, and other locations and may be difficult to remove in many instances. Aqueous fluid compositions effective for removing barite scale may comprise a concentrated mineral acid, a first salt comprising an iodide anion, and a second salt comprising an anion that forms an aqueous-soluble barium salt. One suitable aqueous fluid composition may comprise concentrated hydroiodic acid, an alkali metal iodide, and an alkali metal hypophosphite salt. The aqueous fluid compositions may be used in combination with a second treatment phase comprising a fluid composition comprising at least one acid gas capturing agent. The at least one acid gas capturing agent may comprise a first component reactive toward hydrogen sulfide and an optional second component reactive toward carbon dioxide.
US12227692B1	Composite gels for water shutoff in fractured reservoirs A composition includes a colloidal solution which includes a solvent, a plurality of nanoparticles dispersed in the solvent, an activator dissolved in the colloidal solution, and a plurality of gel particles suspended in the colloidal solution. A method for water shutoff includes injecting a composition into a fracture near a water zone in a formation, wherein the composition includes a colloidal solution which includes a solvent, a plurality of nanoparticles dispersed in the solvent, an activator dissolved in the solvent, and a plurality of gel particles suspended in the colloidal solution.
US12227691B2	Breakable emulsifiers A variety of methods and systems are disclosed, including, in one embodiment, a method for emulsion breaking including: applying a trigger to an oilfield emulsion to facilitate breaking of the oilfield emulsion, wherein the oilfield emulsion includes an oleaginous phase, a non-oleaginous phase, and a breakable emulsifier, wherein the trigger breaks the breakable emulsifier into non-emulsifying byproducts; and separating at least a portion of the oleaginous phase from the non-oleaginous phase.
US12227689B2	Platy chemical heat-storage object A plate-shaped chemical heat storage comprising a substrate composed of a net made of metal and a heat storage material composition supported on the substrate, wherein the heat storage material composition comprises at least one selected from the group consisting of magnesium hydroxide or oxide, strontium hydroxide or oxide, barium hydroxide or oxide, calcium hydroxide or oxide, and calcium sulfate, and optionally at least one selected from the group consisting of titanium dioxide, silicon dioxide, alumina silicate fiber, E-glass fiber and cellulose.
US12227683B2	Connector production method and adhesive film A method of producing a connected body, containing: disposing an adhesive film between a first electronic member having a first electronic electrode and a second electronic member having a second electrode; and pressure-bonding the second electronic member to the first electronic member via the adhesive film so that the second electrode is electrically connected to the first electrode; wherein the first electronic member has an indented surface, the first electrode is provided in a depressed portion of the indented surface, the second electrode has a substantially flat surface having an area larger than an area of the first electrode, the adhesive film contains: first conductive particles that are dendritic conductive particles; and second conductive particles containing a non-conductive core and a conductive layer provided on the core, and the second conductive particles have an average particle diameter of not less than a depth of the depressed portion.
US12227681B2	Laminated armor materials for enhanced ballistic protection The present disclosure relates to laminated armor materials for enhanced ballistic protection. In particular, the present disclosure relates to laminated armor materials comprising first and second armor materials and a laminated adhesive layer comprising nanomaterial fillers.
US12227680B2	Expandable structural adhesive film for dissimilar metal bonding An expandable structural adhesive film for bonding metal parts. The adhesive film comprises at least one first epoxy compound; at least one epoxy curing agent; at least one blowing agent; at least one film-forming agent; and at least one impact modifier. The structural adhesive film exhibits an elongation at break of at least 300% according to tensile test DIN EN ISO 527 and a free expansion rate according to EN 2667-3 of at least 45%.
US12227677B2	Adhesive suitable for an on-the-fly roll change of materials with low-energy surfaces An adhesive that comprises: (a) 35 to 55 wt. % of an elastomer component; (b) 20 to 45 wt. % of an adhesive resin component; and (c) 15 to 40 wt. % of a plasticizing component, wherein (c1) 8 to 35 wt. % of (c) is made of one or more plasticizing oils, and (c2) optionally up to 32 wt. % of (c) is made of one or more plasticizers that differ from plasticizing oils.
US12227675B2	UV curable composition, and UV curable sheet using same Provided are a UV curable composition which can be cured without undergoing a high-temperature heating step and has excellent adhesiveness and mechanical strength; and a sheet using the same. This UV curable composition includes a rubber component having a diene skeleton, a photopolymerization initiator, and a cross-linking agent, wherein the rubber component having a diene skeleton contains a solid rubber component and a liquid rubber component at 25° C. The UV curable composition can be cured by UV irradiation in a short time, and can thus be applied to not only an adherend having high heat resistance but also a wide range of members.
US12227674B2	Polishing composition comprising polishing particles having high water affinity A polishing composition having silica-based abrasive grains and a polishing method. A polishing composition having silica particles, wherein on the basis of a colloidal silica dispersion of the silica particles, the dispersion has an Rsp of 0.15 to 0.7 as measured using pulse NMR, and the colloidal silica particles have a shape coefficient SF1 of 1.20 to 1.80, wherein Rsp is calculated based on equation (1): Rsp=(Rav−Rb)/(Rb) (1) (wherein Rsp is an index that indicates water affinity; Rav is an inverse of a relaxation time of the colloidal silica dispersion; and Rb is an inverse of a relaxation time of a blank aqueous solution obtained by removing the silica particles from the colloidal silica dispersion), and the shape coefficient SF1 is calculated based on equation (2): SF1=(area of a circle whose diameter is a maximum diameter of the particle)/(projected area) (2).
US12227663B2	Flame retardant materials The invention provides a flame retardant material comprising a substrate, an optionally corona-treated coating on the substrate, the coating comprising a polyolefin composition comprising a) an ethylene based plastomer with a density in the range of 0.857 to 0.915 g/cm3 and an MFR2 in the range 0.5-30 g/10 min; b) a propylene based plastomer with a density in the range of 0.860 to 0.910 g/cm3 and an MFR2 in the range 0.01-30 g/10 min; and c) a flame retardant, a primer layer on top of the coating and a lacquer topcoat.
US12227662B2	Multi-fluid kits for three-dimensional printing A multi-fluid kit for three-dimensional printing can include a fusing agent and a coloring agent. The fusing agent can include an electromagnetic radiation absorber in a first liquid vehicle. The electromagnetic radiation absorber can absorb radiation energy and can convert the radiation energy to heat. The coloring agent can include a magenta rhodamine dye and a fluorescence quenching iodide salt in a second liquid vehicle. A molar ratio of the magenta rhodamine dye to the fluorescence quenching iodide salt can range from about 1:1 to about 1:10.
US12227656B2	Multifunctional reactive inks, methods of use and manufacture thereof In one embodiment, a method includes depositing a material on a substrate. The material includes: a plurality of particles configured to complete a self-propagating and/or self-sustaining reaction upon initiation thereof, a solvent system, and one or more stabilizing agents.
US12227655B2	Organopolysiloxane, method of producing the same, and thermally conductive silicone composition An organopolysiloxane is provided. The organopolysiloxane is represented by a general formula.In the general formula, R1 are the same or different aliphatic unsaturated monovalent hydrocarbon groups having 2 to 12 carbon atoms, R2s are the same or different monovalent hydrocarbon groups having 1 to 12 carbon atoms and not having an aliphatic unsaturated bond, R3s are the same or different alkyl groups having 1 to 3 carbon atoms, “n” is an integer of from 1 and 500, and “a” is 0 or 1. A thermally conductive silicone composition having the organopolysiloxane as a component is also provided. The organopolysiloxane can be used as a surface treatment agent for a thermally conductive filler. The organopolysiloxane provides for favorable handling/workability of compositions even if such compositions are highly loaded with a thermally conductive filler.
US12227653B2	Fluorinated coumarins Described herein is fluorinated dye comprising: a fluorescing coumarin-derived moiety connected to an oligomer of hexafluoropropylene oxide via a non-fluorinated divalent linking group. Such fluorinated dyes are soluble in fluorinated fluids and may be used to detect leaks in various systems such as refrigerant, air conditioning and/or heat transfer systems.
US12227650B2	Method of preparing silicone-acrylate hybrid composition and hybrid composition formed thereby A method of preparing a silicone-acrylate hybrid composition is provided. The method comprises irradiating an acrylate composition in the presence of: (i) a silicone article, and/or (ii) a silicone composition; to polymerize the acrylate composition and give the silicone-acrylate hybrid composition. The acrylate composition comprises an acrylate compound and an initiator.
US12227643B2	Liquid chloride salt-based polymer suspension fluids with polyethylene glycol dispersants and application to drag reduction Aqueous suspensions are presented that are stable against settling without additional mixing in which the suspensions comprise a water soluble polymer that is anionic or non-ionic comprising a blend of water with at least about 32 weight percent chloride salt with a counter ion A+a with 2≤a, from about 1 wt % to about 10 wt % particulate polyethylene glycol having an average molecular weight from about 1600 g/mol to about 50,000 g/mol, and from about 10 wt % to about 50 wt % of the water soluble polymer that is not a poly ether. The suspension has chlorides in a sufficient amount to inhibit hydration of the suspended water soluble polymer and the particulate polyethylene glycol. The aqueous suspension can be formed by adding a powder of polyethylene glycol to a high salt solution and then adding the high molecular weight polymer. The aqueous suspensions can be useful as friction reducing agents in flowing liquids, such as for hydraulic fracture.
US12227639B2	Thermoplastic resin composition and exterior material including the same The present disclosure relates to a thermoplastic resin composition and an exterior material including the same. The thermoplastic resin composition includes 100 parts by weight of styrene-based resins; 0.5 to 5 parts by weight of a first polyamide resin having a melting temperature (Tm) of 230° C. or less; and 0.5 to 10 parts by weight of a second polyamide resin having a melting temperature (Tm) of 250° C. or more. Both the first and second polyamide resins have a relative viscosity of 2.5 or less. The present disclosure advantageously provides a low-gloss thermoplastic resin composition having excellent aesthetics, such as softness, luxuriousness, and naturalness, due to uniform and low gloss, and improvement in surface texture while having mechanical properties and processability equal or superior to those of conventional ASA resins; and an exterior material including the low-gloss thermoplastic resin composition.
US12227638B2	Biodegradable composition The invention provides a composition comprising a seaweed extract in an amount of 50-90% by weight, a water-soluble cellulose derivative in an amount of 10-40% by weight and water in an amount of 1-20% by weight, of the total weight of the composition. The invention also provides products, including packaging material, formed from the composition, a method of dissolving, composting and biodegrading the composition or the products, a method of producing the composition and the products, and a method of re-working the composition.
US12227634B2	Fiber sheet and method for producing same A fiber sheet (1) according to the present invention includes a plurality of stem fibers (2) containing a thermoplastic resin and extending in one direction and includes a fibril fiber (3) containing substantially the same thermoplastic resin as the above thermoplastic resin, extending between the stem fibers (2), and having a smaller diameter than that of the stem fibers (2). The plurality of stem fibers (2) include one stem fiber (2) and another stem fiber (2) branching from the one stem fiber and have a void between the stem fibers. The stem fibers (2) hold a plurality of inorganic particles (5). The fiber sheet preferably has a pore volume fraction of 50% or more and 98% or less. In the fiber sheet, the number of fibers having a diameter of 500 nm or less is preferably 50% or more of the total number of the constituent fibers. The inorganic particles preferably include zinc oxide. The fiber sheet is preferably produced by uniaxially drawing a resin sheet containing a thermoplastic resin and inorganic particles.
US12227631B2	Cured product and production method of same, and resin sheet and resin composition Cured products that are formed of a cured material obtained by curing a resin composition including (A) at least one epoxy resin, (B) at least one curing agent, and (C) at least one inorganic filler, and have a ground surface, in which the maximum depth of a depressed portion present on the ground surface is less than 10 μm are useful for making printed wiring boards.
US12227630B2	Method of producing porous body of water-insoluble polymer Provided is a method of producing a porous body of a water-insoluble polymer, the method being excellent in terms of simplicity. The method of producing a porous body of a water-insoluble polymer disclosed here includes the steps of: preparing a solution in which a water-insoluble polymer is dissolved in a mixed solvent containing a good solvent for the water-insoluble polymer and a poor solvent for the water-insoluble polymer; and removing the mixed solvent from the solution by vaporization. The poor solvent has a boiling point higher than a boiling point of the good solvent. A porous body is obtained by removing the mixed solvent by vaporization to form pores.
US12227628B2	Toughened composite materials capable of delamination propagation resistance A curable composite laminate having an interlaminar region formed between adjacent layers of reinforcement fibers. The interlaminar region contains soluble polyimide particles that are dissolvable in the one or more thermoset resins at a curing temperature of the curable matrix resin, and insoluble thermoplastic particles that remain as discrete particles in the interlaminar region at the same curing temperature. Such curable composite laminate is capable of high resistance to the propagation of delamination upon curing.
US12227623B2	Water-absorbing hydrogel and method for producing the same A hydrogel that exhibits excellent water absorbency even when dried, and has flexibility, shape stability, and shape retention properties, and a method for producing the hydrogel. A hydrogel comprising a water-soluble organic polymer, a silicate, a dispersant for the silicate, and a water-absorbing polymer. A method for producing a hydrogel including a formation step of forming a hydrogel comprising a water-soluble organic polymer, a silicate, a dispersant for the silicate, a water-absorbing polymer, and at least one solvent selected from the group having water and a water-soluble organic solvent, and as an optical step, a solvent removal step of removing a portion of the solvent in the hydrogel.
US12227621B2	Film-forming composition A film-forming composition suitable as a resist underlayer film-forming composition from which a resist underlayer film having not only a good EUV resist adhesivity but also a good etching processability due to a high fluorine-based etching rate.For example, a film-forming composition includes a polymer represented by Formula (E1) and a solvent.
US12227619B2	Polyimide based copolymer and electronic component and field effect transistor comprising the same The present invention provides a polyimide-based copolymer and electronic component and field effect transistor comprising the same. The polyimide-based copolymer comprises a copolymer of dianhydride and heterocyclic diamine, wherein the heterocyclic diamine has two benzene rings, and there are two ether bonds, two thioether bonds, or one ether bond and one thioether bond between the two benzene rings. The novel polyimide-based copolymer of the invention has excellent thermal-mechanical stability, has potential application prospects, and can be used as a substrate for flexible electronics.
US12227617B2	Polyamide resin, composition, and molded article Provided are a novel polyamide resin having a high melting point, and a composition and a molded article, for which the novel polyamide resin is used. A polyamide resin including a constituent unit derived from a diamine and a constituent unit derived from a dicarboxylic acid, where 70 mol % or more of the constituent unit derived from the diamine is derived from a xylylenediamine; and 70 mol % or more of the constituent unit derived from the dicarboxylic acid is derived from a phenylenediacetic acid; and where X+(Y/3) is 68 or more, when X mol % is defined as a proportion of a constituent unit derived from 1,4-phenylenediacetic acid in the constituent unit derived from the dicarboxylic acid, and Y mol % is defined as a proportion of a constituent unit derived from p-xylylenediamine in the constituent unit derived from the diamine.
US12227616B2	Fluoropolyether group-containing polymer and production method therefor The present invention is capable of producing a fluoropolyether group-containing polymer, which is represented by general formula (1) (in the formula, Rf is a monovalent or divalent fluoropolyether group-containing polymer residue, X is independently a divalent organic group, and α is 1 or 2), preferably has a number-average molecular weight of 1,000 to 50,000 in terms of polystyrene, and has both a terminal olefin moiety easily converting a functional group and a secondary hydroxyl group having high reactivity, by causing an organometallic reagent having β-hydrogen, specifically, an organometallic reagent having an aliphatic unsaturated double bond (olefin moiety) at a terminal thereof and having β-hydrogen, to act on a fluoropolyether group-containing polymer having a carbonyl group at a terminal thereof.
US12227615B2	Post polymerization modification in flow Techniques regarding post polymerization modifications to polycarbonate polymers via a flow reactor are provided. For example, one or more embodiments described herein can comprise a cyclic carbonate monomer that can be employed to facilitate polymerization of one or more polycarbonate platforms susceptible to post polymerization modification. For instance, one or more embodiments can regard a cyclic carbonate molecular backbone covalently bonded to an aryl halide functional group via in accordance with a chemical structure selected from the group consisting of: In the chemical structures, “R1” can be selected from the group consisting of a hydrogen atom and a functional group comprising a first alkyl group; “L” can represent a linkage group, comprising: a second alkyl group and an end group having at least one member selected from the group consisting of an oxygen atom and a nitrogen atom; and “A” can represent the aryl halide functional group.
US12227614B2	Process for preparing polyoxyalkylene polyester polyols The present invention relates to a process for preparing polyoxyalkylene polyester polyols by reacting a starter compound having Zerewitinoff-active H atoms, a cyclic dicarboxylic acid anhydride and a fatty acid ester with an alkylene oxide in the presence of a basic catalyst. The invention further relates to polyoxyalkylene polyester polyols resulting from the method and to a preparation method for polyurethanes by reaction of the polyoxyalkylene polyester polyols according to the invention.
US12227612B2	Ultrafast cyclic ether-amine photopolyaddition and uses thereof The present invention relates to compositions (self-thermally) curable on demand under the triggering action of UV-visible to near-infrared irradiation of moderate intensity, method of using same for accelerated photopolyaddition of cyclic ether-amine resins or ultrafast dark curing of cyclic ether-amine resins, and articles obtained by such method. The invention also relates to a resin casting, film or coated substrate, and an adhesive layeror bonding agent, comprising acyclic ether-amine resin obtained by an accelerated curing process according to the invention. The invention additionally relates to the use of a composition of the invention for increasing the delamination strength of laminated composite materials.
US12227605B2	High melt strength polypropylene The present invention is related to a high melt strength polypropylene (HMS-PP) comprising units derivable from at least one polyunsaturated fatty acid, a process for preparing said high melt strength polypropylene (HMS-PP), as well as an article comprising said high melt strength polypropylene (HMS-PP).
US12227603B2	Compressed member for electrochemical device A member to be compressed for an electrochemical device obtained by crosslinking a crosslinkable composition containing a fluorine-containing elastomer containing a unit based on at least one crosslinkable group-containing monomer selected from the group consisting of a crosslinkable group-containing monomer (1) represented by the general formula (1): CX12═CF—Rf1—X2 wherein each X1 independently represents H or F, and Rf1 represents a fluorinated alkylene group or a fluorinated oxyalkylene group, and X2 represents I or Br; and a crosslinkable group-containing monomer (2) represented by the general formula (2): CX32═CX3—Z1—CX3═CX32 wherein each X3 independently represents H, F, an alkyl group or a fluorinated alkyl group, and Z1 represents an alkylene group, a fluorinated alkylene group, a cycloalkylene group, a fluorinated cycloalkylene group, an oxyalkylene group or a fluorinated oxyalkylene group.
US12227601B2	Polymeric materials Apparatus for undertaking a chemical reaction includes an elongate housing and a receptacle. The elongate housing may include a cooling means, and end fittings, which may include ports where fluids may be introduced and/or removed. In use of the apparatus, a chemical reaction product is formed within the receptacle. Subsequently the receptacle containing the chemical reaction product is withdrawn from the elongate housing.
US12227594B2	Bispecific 2+1 contorsbodies The invention relates to novel bispecific antibodies consisting of two fusion polypeptides comprising two antigen binding domains capable of specific binding to a first target and one antigen binding domain capable of specific binding to a second target, and to methods of producing these molecules and to methods of using the same.
US12227593B2	Site-specific conjugation of glycosylated monoclonal antibodies with transglutaminase Engineered antibodies useful for site-specific conjugation by a transglutaminase are described. Also described are methods of site-specific conjugation of the antibodies, the site-specifically conjugated antibodies, and pharmaceutical compositions and uses related to the site-specifically conjugated antibodies.
US12227590B2	Methods and composition for a binding molecule targeting cancer cells expressing SSX2 peptide 41-49 in HLA-A*0201 context Disclosed are Synovial Sarcoma X breakpoint 2 binding molecules and methods for their use in the detection and treatment of cancer.
US12227581B2	Anti-BCMA single domain antibodies and application thereof A group of anti-BCMA single domain antibodies, as well as genes of the single domain antibodies in the group, a vector containing the single domain antibodies in the group, a chimeric antigen receptor, and a T cell modified by a chimeric antigen receptor, and detection and treatment application of the single domain antibodies in the group. The anti-BCMA single domain antibodies have high activity, high stability, high specificity, and high binding capability.
US12227580B2	Antigen binding molecules that bind LIGHT The present invention relates to antigen binding molecules, including antibodies, fragments, and variants thereof, that bind to the TNF-related cytokine LIGHT (TNFSF14). The present invention also relates to methods of use of such antigen binding molecules in treating and/or preventing inflammatory disorders and immune disorders.
US12227579B2	Bispecific antibody targeting IL-1R1 and NLPR3 The present disclosure concerns modulators of the NLRP3 inflammasome pathway, in particular an NLRP3 inflammasome modulator which is capable of binding to both of IL-1R1 and NLRP3, for use in the treatment or prophylaxis of inflammatory eye diseases such as glaucoma.
US12227576B2	Methods of treating a tumor using an anti-PD-1 antibody This disclosure provides a method for treating a subject afflicted with tumor, which method comprises administering to the subject an antibody or an antigen-binding portion thereof that specifically binds to a Programmed Death-1 (PD-1) receptor and inhibits PD-1 activity. In some embodiments, the tumor is derived from a non-small cell lung cancer (NSCLC). In some embodiments, the tumor expresses Programmed Death Ligand 1. In some embodiments, the subject carries a wild-type STK11 gene.
US12227575B2	Combination of TIM-4 antagonist and PD-1 antagonist and methods of use Provided are methods and compositions for treating cancer using an effective amount of a PD-1 antagonist (e.g., an antibody) in combination with a TIM-4 antagonist (e.g., an antibody).
US12227572B2	Monoclonal antibodies against the beta chain region of human TRBV9 The invention relates to a monoclonal humanized antibody or antigen-binding fragment thereof that specifically bind to the TRBV9 family of the human T cell receptor. The invention also relates to a nucleic acid encoding said antibody or antigen-binding fragment thereof, an expression vector, a method for preparing said antibody, and use of said antibody in treatment of diseases or disorders associated with the human T cell receptor family. The invention is directed to generation of antibodies that can be used for treating, in particular AS, celiac disease and malignant blood diseases, the pathogenesis of which involves the TRBV9 family TCRs.
US12227569B2	Humanized antibodies with increased stability The present invention provides antibodies having improved stability. Included are antibodies that are capable of binding to KIR3DL2 polypeptides. The antibodies are suitable for the treatment of disorders characterized by KIR3DL2-expressing cells, particularly CD4+ T cells, including malignancies such as Mycosis Fungoides and Sezary Syndrome, and KIR3DL2-expressing autoimmune disorders.
US12227568B2	Anti-Siglec-7 antibodies and methods of use thereof The present disclosure is generally directed to compositions that include antibodies, e.g., monoclonal, chimeric, humanized antibodies, antibody fragments, etc., that specifically bind one or more epitopes within a Siglec-7 protein, e.g., human Siglec-7 or a mammalian Siglec-7, and have improved and/or enhanced functional characteristics, and use of such compositions in preventing, reducing risk, or treating an individual in need thereof.
US12227567B2	Treating cancer by blocking the interaction of TIM-3 and its ligand Provided herein are methods of activating immune response and/or treating cancer in a patient comprising administering to the patient a Gal3:TIM-3 inhibitor that interferes with the interaction between Gal3 and TIM-3, where said inhibitor is administered in an amount sufficient to activate immune response. Also provided are a humanized anti-Gal3 antibodies that can block the interaction between Gal3 and TIM3 and methods of using the anti-Gal3 antibody to treat cancer. Methods for determining if a patient's cancer is suitable for treatment with a Gal3:TIM-3 inhibitor and methods for selecting compounds that can block interaction between Gal3 and TIM-3, activating immune response and/or treating cancer are also provided.
US12227564B2	Anti-GDF15 antibodies, compositions and methods of use The invention provides antibodies, and antigen-binding fragments thereof, that specifically bind to GDF15, as well as methods and uses for the antibodies.
US12227556B2	Immunotherapy with B*08 restricted peptides and combination of peptides against cancers and related methods The present invention relates to peptides, proteins, nucleic acids and cells for use in immunotherapeutic methods. In particular, the present invention relates to the immunotherapy of cancer. The present invention furthermore relates to tumor-associated T-cell peptide epitopes, alone or in combination with other tumor-associated peptides that can for example serve as active pharmaceutical ingredients of vaccine compositions that stimulate anti-tumor immune responses, or to stimulate T cells ex vivo and transfer into patients. Peptides bound to molecules of the major histocompatibility complex (MHC), or peptides as such, can also be targets of antibodies, soluble T-cell receptors, and other binding molecules.
US12227554B2	Methods for selectively expanding cells expressing a TCR with a murine constant region Disclosed are methods of selectively expanding a number of T cells. The methods may comprise: modifying human T cells to express a TCR, wherein the TCR comprises a murine constant region; producing a population of cells comprising a number of human T cells expressing the TCR and a number of human T cells not expressing the TCR; and culturing the population of cells in the presence of (i) irradiated feeder cells, (ii) one or more cytokines, and (iii) an antibody, or an antigen-binding portion thereof, wherein the antibody has antigenic specificity for the murine constant region of the TCR, so as to selectively expand the number of T cells expressing the TCR over the number of T cells not expressing the TCR. Also disclosed are related populations of cells, pharmaceutical compositions, and methods of treating or preventing cancer.
US12227551B2	Membrane bound IL12 compositions and methods for tunable regulation The present disclosure provides regulatable biocircuit systems. Such systems provide modular and tunable protein expression systems in support of the discovery and development of therapeutic modalities.
US12227549B2	RNA encoding a therapeutic protein The present invention relates to an RNA encoding a therapeutic protein. In particular, the present invention relates to RNA suitable for use as a medicament. The present invention concerns such novel RNA as well as compositions and kits comprising the RNA. Furthermore, the present invention relates to the RNA, compositions or kits as disclosed herein for use as a medicament. The present invention also provides the use of the RNA, compositions or kits as disclosed herein for increasing the expression of said encoded protein, in particular in gene therapy.
US12227542B2	Method for producing peptide compound, protective group-forming reagent, and condensed polycyclic compound Provided are a method for producing a peptide compound including a step of using a compound represented by Formula (1); a protective group-forming reagent including the compound; and the compound. At least one of R1 to R8 or Y2 has RA, RA represents an aliphatic hydrocarbon group or an organic group having an aliphatic hydrocarbon group, and the number of carbon atoms in at least one aliphatic hydrocarbon group is 12 or more. However, RA does not have a silyl group and a hydrocarbon group having a silyloxy structure.
US12227541B2	Sterol derivatives and preparation method and uses thereof The present invention pertains to pharmaceutical chemical field, and relates to a sterol derivative as well as preparation method and uses thereof. Specifically, the present invention relates to a compound of Formula I, or a pharmaceutically acceptable salt, ester or ether thereof, wherein, R1 is selected from the group consisting of —OH, ═O(carbonyl), H, and C1-C3 alkyl; R2 is selected from the group consisting of —OH, H, and C1-C3 alkyl; R3 is selected from the group consisting of —OH, ═O, H, and C1-C3 alkyl; R4 is selected from the group consisting of —OH, H, and C1-C3 alkyl; and none, one, two, three or four of R1, R2, R3, and R4 are —OH. The compound of the present invention can inhibit HMG-CoA reductase, tumor cells and lipase effectively, and is a potential drug for reducing blood-fat, antitumors, or for losing weight.
US12227536B2	Crystalline forms of an NRTTI compound The present disclosure provides novel anhydrate crystalline Forms 1 and 4 of 4′-Ethynyl-2-fluoro-2′-deoxyadenosine and pharmaceutical compositions thereof, each of which may be useful for the inhibition of HIV reverse transcriptase, the treatment or prophylaxis of HIV infection and/or the treatment, prophylaxis and/or delay in the onset or progression of AIDS or ARC.
US12227535B2	Triterpene saponins, methods of synthesis and uses thereof The present invention relates to triterpene glycoside saponin-derived adjuvants, syntheses thereof, intermediates thereto, and uses thereof. QS-7 is a potent immuno-adjuvant that is significantly less toxic than QS-21, a related saponin that is currently the favored adjuvant in anticancer and antiviral vaccines. Tedious isolation and purification protocols have hindered the clinical development of QS-7. A novel semi-synthetic method is provided wherein a hydrolyzed prosapogenin mixture is used to synthesize QS-7, QS-21, and related analogs, greatly facilitating access to QS-7 and QS-21 analogs for preclinical and clinical evaluation.
US12227533B2	Crystalline forms and methods of producing crystalline forms of a compound Disclosed herein are methods of crystallizing the compound of Formula I, as well as crystalline forms thereof. Crystalline forms of Formula I disclosed include the TBME solvate crystalline form, toluene solvate crystalline form, ethanol solvate crystalline form, THF solvate crystalline form, EtOAc solvate crystalline form, acetone solvate crystalline form and crystalline Form C.
US12227530B2	Method of preparing functional organosilanol compounds A method of preparing an organosilanol compound is disclosed. The method comprises reacting (A) an initial organosilicon compound and (B) water in the presence of (C) a catalyst. The catalyst (C) is selected from: (C1) [(C8H12irCl]2[(p-cymene)RuCl2]2; and (C3) Pd/C. The initial organosilicon compound (A) has the general formula HO—Si(R)2—[Si(R)2O]a—OSi(R)2—Y and the organosilanol compound has the general formula HO—Si(R)2-[Si(R)2O]a—OSi(R)2—Y, where each R is an independently selected hydrocarbyl group; Y comprises a functional moiety selected from alkoxysilyl moieties, epoxide moieties, and acryloxy moieties, with the proviso that Y is other than the acryloxy moieties when the catalyst (C) is (C3) Pd/C; and subscript a is 0 or 1. The organosilanol compound prepared by the method is also provided.
US12227526B2	Metal-organic framework materials comprising a diimine scaffold and methods for production thereof Metal-organic framework materials (MOFs) are highly porous entities comprising a multidentate organic ligand coordinated to multiple metal centers, typically as a coordination polymer. Crystallization may be problematic in some instances when secondary binding sites are present in the multidentate organic ligand. Multidentate organic ligands comprising first and second binding sites bridged together with a third binding site comprising a diimine moiety may alleviate these issues, particularly when using a preformed metal cluster as a metal source to form a MOF. Such MOFs may comprise a plurality of metal centers, and a multidentate organic ligand coordinated to the plurality of metal centers to define an at least partially crystalline network structure having a plurality of internal pores, and in which the multidentate organic ligand comprises first and second binding sites bridged together with a third binding site comprising a diimine moiety. Particular MOFs may comprise N,N′-di(1H-pyrazol-4-yl)ethane-1,2-diimine as a multidentate organic ligand.
US12227525B2	Organic electroluminescent materials and devices Provided are compounds of formula Ir(L1)x(L2)y(L3)z where L1 has L1 forms a 5-membered chelate ring with Ir; and L2 and L3 can be the same or different and have
US12227524B2	Anti-infective compounds The present invention relates to small molecule compounds and their use in the treatment of bacterial infections, in particular Tuberculosis.
US12227516B1	Selective COX-2 inhibition of 2-(substituted benzyl)-3,5,6,7-tetrahydro-4H-cyclopenta[4,5]thieno[2,3-d]pyrimidin-4-ones and 4-fluoro-n-(4-oxo-3,5,6,7-tetrahydro-4H-cyclopenta[4,5]thieno[2,3-d]pyrimidin-2-yl)benzamide as anti-inflammatory agents Novel 2-(substituted benzyl)-3,5,6,7-tetrahydro-4H-cyclopenta[4,5]thieno[2,3-d]pyrimidin-4-ones and 4-fluoro-N-(4-oxo-3,5,6,7-tetrahydro-4H-cyclopenta[4,5]thieno[2,3-d]pyrimidin-2-yl)benzamide compounds, a method of synthesizing said compounds, a pharmaceutical composition comprising said compounds and a suitable carrier, and a method of using the compounds. The 2-(substituted benzyl)-3,5,6,7-tetrahydro-4H-cyclopenta[4,5]thieno[2,3-d]pyrimidin-4-ones and 4-fluoro-N-(4-oxo-3,5,6,7-tetrahydro-4H-cyclopenta[4,5]thieno[2,3-d]pyrimidin-2-yl)benzamide compounds, identified as COX-2 inhibitors, are useful as anti-inflammatory and pain agents.
US12227512B2	Benzimidazoles and methods of using same The present disclosure is concerned with benzimidazole compounds and methods of using these compounds for the treatment of hepatitis (e.g., hepatitis C), RNA virus infections (e.g., Zika virus, dengue virus, Powassan virus, Chikungunya virus, Enterovirus, respiratory syntactical virus (RSV), Rift Valley fever, Influenza virus, Tacaribe virus, Mayaro virus, West Nile virus, yellow fever virus, and coronavirus), and disorders of uncontrolled cellular proliferation (e.g., cancer). This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.
US12227511B2	Bicyclic compounds as kinase modulators, methods and uses thereof The present disclosure relates to derivatives of bicyclic compounds and their uses in therapy. In particular, the present disclosure relates to derivatives of bicyclic compounds for use in modulating kinase enzymatic activity and accordingly modulating kinase-dependent diseases and conditions such as cancer and in specific embodiments, hepatocellular carcinoma (HCC). The present disclosure also relates to methods of synthesizing these compounds.
US12227508B2	TGF-β inhibitors Disclosed are pyrazole compounds, as well as pharmaceutical compositions and methods of use thereof. One embodiment is a compound having the structure and pharmaceutically acceptable salts, prodrugs and N-oxides thereof (and solvates and hydrates thereof), wherein A, X, Z, m, p, and R2 are as described herein. In certain embodiments, a compound disclosed herein inhibits the activity of one or more members of the TGF-β superfamily, and can be used to treat disease by blocking such activity.
US12227506B2	Crystalline polymorphs of 1-[(3R)-3-[4-amino-3-(4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl]-1-piperidinyl]-2-propen-1-one and process for preparation thereof The present invention relates to novel crystalline polymorphs of 1-[(3R)-3-[4-amino-3(4-phenoxy phenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl]-1-piperidinyl]-2-propen-1-one represented by the following structural formula-1 and process for preparation thereof.
US12227505B2	Supercritical fluid extraction process with integrated pressure exchanger Processes and apparatuses for soluble compound recovery using supercritical fluid (SCF) are disclosed. An example process involves solvent extraction of a soluble compound using a SCF from a solid or liquid substrate including, but not limited to, microalgae, plant matter, and polymers. The apparatus comprises SCF, an extraction vessel, a pressure exchanger, a separate soluble compound, and solid or liquid compound separators.
US12227501B2	3-amino-2-[2-(acylamino)pyridin-4-yl]-1,5,6,7-tetrahydro-4h-pyrrolo[3,2-c]pyridin-4-one as CSNK1 inhibitors The present invention relates to compounds of formula (I) processes for their production and their use as pharmaceuticals. The compounds are inhibitors of Casein kinase 1 alpha and/or delta (CSNK1α and/or β) useful for the treatment of proliferative disorders.
US12227497B2	Solid forms of(Z)-4-(5-((3-benzyl-4-oxo-2-thioxothiazolidin-5-ylidene)methyl)furan-2-yl)benzoic acid The present invention provides new salts and crystalline forms of leukadherin LA1 [(Z)-4-(5-((3-benzyl-4-oxo-2-thioxothiazolidin-5-ylidene)methyl)furan-2-yl)benzoic acid] according to Formula I. Methods for preparation of the salts and crystalline forms are also described, as well as methods for treating β2 integrin-mediated diseases and conditions using the salts and crystalline forms.
US12227495B2	Herbicidal compounds The present invention relates to compounds of Formula (I) or an agronomically acceptable salt of said compounds wherein Q, R1, R2, n and m are as defined herein. The invention further relates to herbicidal compositions which comprise a compound of Formula (I) and to the use of compounds of Formula (I) for controlling weeds, in particular in crops of useful plants.
US12227489B2	Dichlorophenol HSD17B13 inhibitors and uses thereof Described herein are HSD17B13 inhibitors and pharmaceutical compositions comprising said inhibitors. The subject compounds and compositions are useful for the treatment of liver disease, metabolic disease, or cardiovascular disease, such as NAFLD or NASH, or drug induced liver injury (DILI).
US12227485B2	Compounds useful for the treatment of infection with Mannheimia haemolytica or Histophilus somni The present invention discloses compounds that are useful in the treatment of respiratory diseases of animals, especially Bovine or Swine Respiratory disease (BRD and SRD).
US12227481B2	Crystalline solid forms of salts of N-{4-[(6,7-dimethoxyquinolin-4-yl)oxy]phenyl}-N'-(4-fluorophenyl) cyclopropane-1,1-dicarboxamide, processes for making, and methods of use The invention relates to novel crystalline solid forms of salts of the chemical compound N-{4-[(6,7-dimethoxyquinolin-4-yl)oxy]phenyl}-N′-(4-fluorophenyl) cyclopropane-1,1-dicarboxamide, and solvates thereof, including hydrates, that are useful for the treatment of cancer. Also disclosed are pharmaceutical compositions comprising the crystalline solid forms and processes for making the crystalline solid forms, as well as methods of using them for the treatment of cancer, particularly renal cell carcinoma (RCC) and medullary thyroid cancer (MTC).
US12227476B2	Preparation method for levetiracetam intermediate A high-quality (RS)-α-ethyl-2-oxo-1-pyrrolidine acetic acid acquired by racemization recovery is provided. A method provided significantly increases the quality and appearance of the product (RS)-α-ethyl-2-oxo-1-pyrrolidine acetic acid recovered using racemization and does not affect the product yield.
US12227474B2	Methods of producing and recovering levulinic acid The disclosure relates to methods of producing and recovering levulinic acid.
US12227472B2	Series of skin-whitening (lightening) compounds The present invention is directed to inhibitors of tyrosinase, pharmaceutical compositions comprising such tyrosinase inhibitors, and methods of making and using the same. Specifically, included in the present invention are compositions of matter comprised of at least one 2,4-dihydroxybenzene analog, which inhibit the activity of tyrosinase and which inhibit the overproduction of melanin.
US12227470B2	Purification of alkyl hydroperoxide by extractive distillation The invention relates to a method for purifying an alkyl hydroperoxide from dialkyl peroxide thereof, comprising a step of distillation in the presence of alcohol and water followed by extraction of the condensates using a hydrocarbon or a hydrocarbon blend.
US12227468B2	Process for the co-production of methyl mercaptan and of dimethyl disulfide from carbon oxides The invention relates to a process for the co-production of methyl mercaptan and of dimethyl disulfide, comprising the following successive steps: a) reaction of at least one carbon oxide in the presence of hydrogen sulfide (H2S) and hydrogen to form a stream (M) comprising methyl mercaptan, water, and possibly unreacted hydrogen sulfide, b) purification of the stream (M) to obtain a stream (N) enriched in methyl mercaptan and a stream containing the uncondensable compounds (Muncond), c) optional recycling of the stream of uncondensable compounds (Muncond) obtained from step b) into step a), d) recovery of a first portion of the stream (N) including methyl mercaptan purified in step b), e) oxidation with sulfur of the second portion of the stream (N) of methyl mercaptan, to form a stream (O) comprising dimethyl disulfide, hydrogen sulfide, and possibly unreacted methyl mercaptan, f) purification of the stream (O) to separate, on the one hand, the enriched dimethyl disulfide and, on the other hand, the hydrogen sulfide and possibly the methyl mercaptan that has not reacted in step e), g) recycling of the hydrogen sulfide and possibly of the methyl mercaptan isolated in step f) into the stream (M) obtained from step a), h) recovery of the dimethyl disulfide isolated in step f).
US12227464B2	CMAS-resistant environmental barrier coating system An article may include a substrate, such as a silicon-containing ceramic matrix composite, an environmental barrier coating (EBC) layer on the substrate, and a CMAS-resistant EBC layer on the EBC layer. The EBC layer may include at least one rare-earth disilicate (REDS). The CMAS-resistant EBC layer may include at least one rare-earth monosilicate (REMS) configured to react with CMAS to form crystalline reaction products. The CMAS-resistant EBC layer may include a plurality of vertical cracks extending from a surface of the CMAS-resistant EBC layer at least partially into the CMAS-resistant EBC layer. Additionally, or alternatively, the EBC layer may include a plurality of vertical cracks extending from a surface of the EBC layer into at least a portion of the EBC layer.
US12227463B2	Environmental barrier coating and method of forming the same A method of applying a coating to a substrate includes forming a slurry by mixing elemental precursors of gettering particles, diffusive particles, matrix material, and a carrier fluid; applying the slurry to a substrate; and sintering the slurry to form a composite material. The sintering causes the elemental precursors to react with one another to form gettering particles. An article is also disclosed.
US12227459B2	Mixed waste plastics compatibilizers for asphalt An asphalt modifier includes bitumen, polyolefin particles, and one or more alkyl terephthalamides. Preparing an asphalt modifier includes combining one or more alkyl terephthalamides, polyolefin particles, and bitumen, and dispersing the polyolefin particles in the bitumen to yield the asphalt modifier. Digesting polyethylene terephthalate includes combining polyethylene terephthalate with an alkylamine or carboxyalkylamine to yield a reaction mixture, and heating the reaction mixture to a temperature between about 20° C. and about 300° C. to yield an alkyl terephthalamide.
US12227457B2	Admixture for a cementitious material to influence the rheology properties of the cementitious material The invention relates to an admixture for a cementitious material suitable to influence the rheological properties of the cementitious material. The admixture includes a compound having a backbone chain provided with at least one first functionality and at least one second functionality. The at least one first functionality is adapted to adsorb to the cement particles of the cementitious material. The at least one second functionality is adapted to respond to an external trigger signal of an electric field, a magnetic field or an electromagnetic field, thereby influencing the rheological properties of the cementitious material. The rheological properties are influenced by influencing the interaction of the at least one first functionality with the cement particles and/or by influencing the interparticle interaction between the cement particles. The invention further relates to a cementitious material including such admixture. Furthermore, the invention relates to a method and a system to control or influence the rheological properties of a cementitious material.
US12227454B1	Wire mesh concrete reinforcement members and methods of use thereof A fiber reinforced concrete includes a plurality of reinforcing wire meshes scattered and suspended in random orientation throughout the volume of concrete. The reinforcing wire meshes include a first set of two or more parallel wires extending along their length in a common plane and a second set of three parallel wires orthogonal to the first set along their length in a common plane. The first set and second set constitute an entire reinforcing member. The wire meshes may be formed by casting or welding in which the wires lie in a common plane or separate planes, respectively. The reinforcing members may have a total of two or four contiguous rectangles arranged in a mesh pattern. Free ends of the reinforcing members may be included and extend beyond the mesh pattern for increased anchorage. A method of reinforcing concrete is disclosed and may include a central or diagonal bend in the reinforcing members.
US12227450B2	Stucco properties through aging at elevated temperatures and high humidity level The invention pertains to a method for stabilizing stucco wherein a fresh stucco is provided; water is added to the fresh stucco to obtain moistened stucco, and the moistened stucco is maintained at a temperature of at least 30° C. for a time interval of at least 30 minutes to obtain a stabilized stucco. The process allows inter alia for an easy adjustment of the activity of the stabilized stucco, which is useful to e.g. adjust setting time of a corresponding stucco slurry. The invention further pertains to a method for producing gypsum plasterboards, wherein a stabilized stucco obtained with the above method is used.
US12227449B2	Zircon compatible, ion exchangeable glass with high damage resistance An ion exchangeable glass having a high degree of resistance to damage caused by abrasion, scratching, indentation, and the like. The glass comprises alumina, B2O3, and alkali metal oxides, and contains boron cations having three-fold coordination. The glass, when ion exchanged, has a Vickers crack initiation threshold of at least 10 kilogram force (kgf).
US12227448B2	Flash annealing of silver coatings Methods of processing coated articles, such as transparencies, are provided comprising flash annealing one or more layers of the coated article. The one or more layers may be reflective metallic layers, such as silver layers, or comprise a transparent conductive oxide, such as indium tin oxide, or a semiconductor.
US12227442B2	Treatment of saline water for agricultural and potable use Water treatment systems including electrically-driven and pressure-driven separation apparatus configured to produce a first treated water suitable for use as irrigation water and a second treated water suitable for use as potable water from one of brackish water and saline water and methods of operation of same.
US12227440B2	Cerium-lanthanum treatment method for reduction of contaminants in wastewater membrane bioreactors Disclosed are methods of treating wastewater using a membrane bioreactor and achieving a target phosphorus concentration for the membrane permeate stream. These methods include the steps of dosing a wastewater stream with a rare earth clarifying agent and passing the dosed wastewater stream through the membrane to obtain a membrane permeate stream with a permeate concentration that is less than the phosphorus concentration of the influent stream. This permeate concentration also can be equal to or less than a target phosphorus concentration. In the methods as disclosed herein, the rare earth clarifying agent can be chloride salts of one or more rare earth elements and in certain embodiments, the rare earth clarifying agent can be CeCl3 and LaCl3.
US12227437B1	Water treatment system using reverse osmosis process for high salinity low temperature water A water treatment system comprising a filtration system and a reverse osmosis treatment system, incorporates a system cleansing process the uses feedwater to flush the system and further conveys reverse osmosis treated water through the system conduits by allowing the reverse osmosis treated water to settle at a low pressure system operation, and further by flushing the reverse osmosis treated water at high pressure. The system may incorporate CIP components, as well as a hydraulic turbocharger for recovering energy and boosting pressure alongside a pump system.
US12227436B2	Method for cleaning up oil spills using multi-layered carbon fiber-based absorbents A method for cleaning up oil spills using multi-layered carbon fiber-based absorbents is disclosed. The method for cleaning up oil spills requires an oil-contaminated area including a quantity of oil, a first storage vessel, an oil extraction machine, a heating element, and a multi-layered carbon fiber absorbent. The multi-layered modified carbon fiber absorbent is distributed to the oil-contaminated area, where the multi-layered modified carbon fiber absorbent is configured to extract the quantity of oil from the oil-contaminated area while maintaining hydrophobic. The quantity of oil is extracted and separated from the multi-layered modified carbon fiber absorbent using the oil extraction machine. The extracted quantity of oil is collected into the first storage vessel. The extract quantity of oil is then transferred over to a second storage vessel for later refinement.
US12227434B2	Humic and fulvic black water based beverage for human consumption The embodiments disclose a method including bottling alcoholic beverages with selected ingredients including alcohol neutral spirits, alcohol and whisky, beer, wine, ingredients to add flavors and nutritional additive ingredients to benefit the health of an alcoholic beverage drinker, wherein a selection of alcohols includes vodka, tequila, gin, rum, brandy and other alcoholic spirits, wherein a selection of ingredients to add flavors includes flavorings including fruit flavorings, an artificial sweetener, and natural sweetener, wherein a selection of nutritional additive ingredients includes vitamins, minerals, fulvic acid, humic acid, ulmic acid and a purified and sanitized black water with humic acid and fulvic acid molecules in a mixed solution, and wherein bottling includes a bottling electronic monitoring, at least one control network, at least one bottling quality control process and a bottling labeling and packaging process and devices.
US12227430B2	Cobalt oxide as a precursor of positive electrode materials for rechargeable lithium ion batteries A cobalt oxide precursor powder for use in preparing a positive electrode active material and methods of production thereof are described. The precursor powder comprises particles has a Fd-3m structure and a formula Co1-yAyOx, wherein 1
US12227428B2	Nanocrystal-sized cerium-zirconium-aluminum oxide material and method of making the same A nanocrystal-sized cerium-zirconium-aluminum mixed oxide material includes at least 20% by mass zirconium oxide; between 5% to 55% by mass cerium oxide; between 5% to 60% by mass aluminum oxide; and a total of 25% or less by mass of at least one oxide of a rare earth metal selected from the group of lanthanum, neodymium, praseodymium, or yttrium. The nanocrystal-sized cerium-zirconium-aluminum mixed oxide exhibits hierarchically ordered aggregates having a dso particle size less than 1.5 μm, and retains at least 80% of surface area and pore volume after ageing at temperature higher than 1000° C. for at least 6 hours. The nanocrystal-sized cerium-zirconium-aluminum mixed oxide material is prepared using a co-precipitation method followed by milling the dried and calcined oxide material. The nanocrystal-sized cerium-zirconium-aluminum mixed oxide material forms a particulate filter that may be used in an exhaust system arising from a gas or diesel engine.
US12227420B2	Laser-induced graphene sensors and methods of making and using same Gas sensors having laser-induced graphene (LIG) and/or LIG composites, and methods of making and using gas sensors having LIG and/or LIG composites.
US12227418B2	Method of recycling carbon fibers An object of the present disclosure is to provide a method of recycling carbon fibers that allows efficiently obtaining carbon fibers suitable for reuse. An embodiment is the method of recycling carbon fibers that includes: preparing a carbon fiber reinforced plastic molded product containing a carbon fiber reinforced plastic containing a carbon fiber and a resin; performing a process of at least one of a heating process or an ultraviolet irradiation process on the carbon fiber reinforced plastic molded product; and removing the resin after the process from the carbon fiber by injecting a first liquid to at least the carbon fiber of the carbon fiber reinforced plastic molded product after the process.
US12227416B2	Pre-combustion CO2 removal in a natural gas fed steam methane reformer (SMR) based hydrogen plant In a hydrocarbon-fed steam methane reformer hydrogen-production process and system, carbon dioxide is recovered in a pre-combustion context, and optionally additional amounts of carbon dioxide are recovered in a post-combustion carbon dioxide removal, to provide the improved carbon dioxide recovery or capture disclosed herein.
US12227413B2	Composite loaded with nano-magnesium hydride and preparation method thereof Disclosed is a method for preparing a composite loaded with nano-magnesium hydride, including: adding a cationic surfactant into an aqueous dispersion of a two-dimensional transition metal carbide such that a nanosheet of the two-dimensional transition metal carbide wrinkles, to avoid re-stacking, and then washing and drying; placing a dried product into a sealed container, vacuuming the sealed container, heating to a high temperature, and holding at the high temperature for a period of time; filling the sealed container with high-pressure hydrogen and holding for a period of time to obtain a heated product; adding the heated product and dibutyl magnesium into an organic solvent, conducting ultrasonic dispersion, then heating under stirring at a hydrogen pressure of 3 MPa to 6 MPa and a temperature of 180° C. to 220° C. for 12 h to 48 h, and centrifuging and drying to obtain the composite loaded with nano-magnesium hydride.
US12227412B2	Porous one-dimensional polymeric graphitic carbon nitride-based nanosystems for catalytic conversion of carbon monoxide and carbon dioxide under ambient conditions In some aspects and embodiments, the present application provides a wide range of porous 1-D polymeric graphitic carbon-nitride materials that are atomically doped with binary metals in different morphologies. In some embodiments, the graphitic carbon-nitride materials can be prepared with high mass production from inexpensive and natural abundant precursors. In some embodiments, the materials were used successfully for the oxidation of CO to CO2 under ambient reaction temperature in addition to the reduction of CO2 into hydrocarbons. In some embodiments, the materials can be used for practical and large-scale gas conversion for household or industrial applications.
US12227410B2	Semiconductor device and method for forming the same The present disclosure provides a semiconductor device. The semiconductor device includes a first device and a second device disposed adjacent to the first device; a conductive pillar disposed adjacent to the first device or the second device; a molding surrounding the first device, the second device and the conductive pillar; and a redistribution layer (RDL) over the first device, the second device, the molding and the conductive pillar, wherein the RDL electrically connects the first device to the second device and includes an opening penetrating the RDL and exposing a sensing area over the first device.
US12227409B2	Robust inertial sensor self-test An inertial sensor such as a MEMS accelerometer or gyroscope has a proof mass that is driven by a self-test signal, with the response of the proof mass to the self-test signal being used to determine whether the sensor is within specification. The self-test signal is provided as a non-periodic self-test pattern that does not correlate with noise such as environmental vibrations that are also experienced by the proof mass during the self-test procedure. The sense output signal corresponding to the proof mass is correlated with the non-periodic self-test signal, such that an output correlation value corresponds only to the proof mass response to the applied self-test signal.
US12227408B2	Fluid dispensing device with reduced opening force A nozzle for dispensing fluid including a nozzle body having a fluid path therein through which fluid is configured to flow in a downstream direction. The nozzle further includes a valve having a valve body positioned in the fluid path and movable between a closed position wherein the valve body sealingly engages a valve seat to generally block fluid from flowing therethrough, and an open position wherein the valve body is spaced away from the valve seat to generally allow fluid to flow therethrough. At least part of a surface of the valve body positioned upstream of the valve seat is configured to be fluidly isolated from a pressure of fluid in the fluid path upstream of the valve seat when the valve is in the closed position.
US12227407B1	Bottle According to some embodiments, a bottle is disclosed. The bottle includes a main storage area, a dosage storage chamber, and a dispensing neck. The dosage storage chamber is coupled to the main storage area via a fluid channel. The dispensing neck extends from the dosage storage chamber for dispensing a content of the bottle. In a case that the dispensing neck is positioned parallel with the ground, the content of the bottle in the dosage storage chamber will not flow into the dispensing neck.
US12227402B2	Stowable modular utility lift system The subject invention pertains to stowable, modular lift conversion systems configured for aftermarket or OEM application to a truck, all-terrain vehicle (ATV), or utility task vehicle (UTV). Lift systems provided include removable and mounted systems with power provided by a battery, a winch, or linear motion device either on the lift or on the vehicle. Modular implements and lift attachments are provided.
US12227400B2	Intelligent vehicle lift network with distributed sensors An automation system uses cameras (134) and sensors (136) to identify a set of vehicle wheels within a lift area (118), then virtualizes the position and orientation of the vehicle relative to the lift posts (122, 130). Lift arms (124, 132) extending from the lift posts are moved to a first position that places a profile camera near the predicted position of lift points, and image analysis is used to positively identify the lift points. The lift arms are then moved to a second position that places an adapter camera below the identified lift points, and image analysis is used to confirm safe positioning below the lift point. Captured images and feedback from image analysis are used to improve and refine the system's ability to identify wheels, profile view lift points, and plan view lift points. The system may be integrated with lift arms allowing for automated rotation, extension, and elevation of lift adapters.
US12227399B2	Control of chain hoist A method comprising: detecting the start of resonance when the chain hoist moves a load, determining a new speed for the rotation of the chain wheel of the chain hoist to avoid resonance, and controlling the chain hoist to use the new speed.
US12227396B2	Work machine This work machine includes: an actuator that extends and retracts a telescopic boom; an electric drive source that is provided in the actuator and drives using power supplied from a power source; an operating unit that operates based on power of the electric drive source; an electric circuit capable of switching between a drive state in which a supply of power from the power source to the electric drive source is allowed to drive the electric drive source, and a braking state in which the supply of power from the power source to the electric drive source stops to generate a braking force to be applied to the electric drive source; and a control unit that controls the switching between the drive state and the braking state.
US12227395B2	Dynamic flex compensation, coordinated hoist control, and anti-sway control for load handling machines Various example embodiments relate to motion control of a target such as a suspended load. An apparatus may comprise: a floating base comprising an exteroceptive observation system configured to measure a position or velocity of at least one target with respect to a reference coordinate frame moving with the floating base. The floating base may further comprise an inertial measurement unit configured to measure at least one inertial state of the floating base with respect to an inertial reference coordinate frame. Position or velocity compensation for the at least one target may be performed based on the at least one inertial state of the floating base.
US12227390B2	Elevator guide An elevator guide having a base attached to an elevator component, a guide riding along a portion of a rail and a spring biasing the guide in contact with the rail. The guide includes one or more of the following: (i) a guide support member operably associated with the guide for movably supporting the guide so that the guide can move toward and away from a corresponding surface of the rail member wherein the guide support member has a plurality of spring engagement sections configured to vary a system effective spring rate; (ii) a roller including a non-metallic rim molded about a bearing; (iii) two independently adjustable stops and, (iv) an opening adjustment member mounted about a notch in the base to vary the distance between the base and the rail. The opening adjustment member has a width and/or depth greater than a width and/or depth of the notch.
US12227388B2	Elevator which performs a releveling operation based on a car height An elevator apparatus which includes a car; a hoisting rope having an expansion and contraction amount which varies depending on a height of the car; and a counterweight which on an opposite side of the car via the hoisting rope. The hoisting rope is wound around a hoisting machine, and the car is elevated when the hoisting rope is wound by the hoisting machine. In a control device of the elevator apparatus, a speed-command corrector corrects a base speed command, which is generated by a re-leveling operation controller, based on a current height of the car.
US12227387B2	Automatic document feeding device An automatic document feeding device having a main body, a stopping assembly, an actuating assembly and a controller. The main body has a sheet conveying channel of a curvature shape. A sheet feeding roller assembly and a sheet conveying roller assembly are arranged on the sheet conveying channel. The stopping assembly is arranged between the sheet feeding roller assembly and the sheet conveying roller assembly. The stopping assembly is capable of being located in or out of the sheet conveying channel. A buffering channel is located between the stopping assembly and the sheet feeding roller assembly. The controller is electrically connected with the actuating assembly and the sheet feeding roller assembly. The controller controls the actuating assembly to hold the stopping assembly in the sheet conveying channel to block the sheet conveying channel in a predetermined period, and then controls the actuating assembly to stop holding the stopping assembly.
US12227385B2	Sheet transport device and image forming apparatus A sheet transport device includes: a curved sheet transport path; multiple transport roller pairs disposed in the sheet transport path; multiple driving sources that drive the multiple transport roller pairs; multiple load detectors that detect the loads of the multiple driving sources; and a control unit that controls the driving speed of at least one of the driving sources such that detection results obtained by the load detectors are within a predetermined range in accordance with the position of the leading end of a sheet.
US12227383B2	Sheet processing apparatus and image forming system incorporating the sheet processing apparatus A sheet processing apparatus includes a tray, a first binder, a second binder, a feeder, and circuitry. The tray receives and stores a sheet bundle. The first binder presses the sheet bundle to bind the sheet bundle. The second binder penetrates the sheet bundle with a needle to bind the sheet bundle. The feeder feeds the sheet bundle in a first direction, and moves the sheet bundle in a second direction. The circuitry causes the feeder to move the sheet bundle on the tray in the second direction, moves the first binder from a binding position to a home position different from the binding position, and moves the second binder to the binding position in the width direction to bind the sheet bundle by the second binder after the sheet bundle is moved in the second direction and the first binder is moved to the home position.
US12227379B2	Adhesive film production apparatus and reel bodies Provided is an adhesive film production apparatus for producing an adhesive film having an adhesive layer on a base material layer, the adhesive film production apparatus including: a feeding roller that continuously feeds a raw film of the adhesive film; a cutting part that cuts the raw film of the adhesive film into a plurality of adhesive films having predetermined widths; and a plurality of winding cores that wind each of the plurality of adhesive films, wherein each of the plurality of winding cores has a width larger than a width of the adhesive film as an object of winding.
US12227378B2	Hand dispenser for stretch wrap comprised of paper or cardbaord A film dispenser for dispensing stretch wrap or other flexible materials. The film dispenser is comprised of paper or cardboard. The film dispenser being inserted into an extended core or having the extended core inserted into the film dispenser.
US12227377B2	Enclosed foam ramp A ramp has a first end and a second end. The ramp includes a form core which has a first core surface and a second core surface. A metal skin is secured to and at least partially surrounds the form core. The metal skin forms at least a first skin surface secured to the first core surface and a second skin surface secured to the second core surface.
US12227373B2	Article transport vehicle, rail assembly, and article transport system including the same According to an embodiment of the present invention, there is provided an article transport vehicle capable of speeding up and reducing vibration in a manufacturing plant, a rail assembly, and an article transport system including the same. The article transport vehicle that conveys an article between manufacturing facilities along a rail of an article transport system in a manufacturing plant includes an article holder, a vehicle body, a magnetic levitation actuator, and a linear motor coil.
US12227371B2	Roller conveyor gap filler system A roller gap filler system for a conveyor having rollers. The system including a first mounting bracket, second mounting bracket, and first filler bar. The first mounting bracket is configured to mount adjacent a first end of the rollers, and the second mounting bracket is configured to mount adjacent a second end of the rollers, where the second end is opposite the first end. The first filler bar is configured to extend between the first mounting bracket and the second mounting bracket and be positioned between a first roller and a second roller of the plurality of rollers. A plunger is associated with the first filler bar, the plunger being moveable between a coupling position to couple the first filler bar to the second mounting bracket and a release position to uncouple the first filler bar from the second mounting bracket, where the plunger is biased to the coupling position.
US12227370B2	Apparatuses and methods for measuring dustiness of a product A method for measuring dustiness of a product. The method can include providing the product onto a ramp. The method further can include allowing gravity to move the product down the ramp through a dam. The dam can be configured to control a mass flow rate of the product moved down the ramp. The method additionally can include measuring, by a sensor, airborne particles to determine the dustiness of the product, wherein the airborne particles are generated by the product exiting the ramp and freely falling onto a support surface. Other embodiments are disclosed.
US12227369B2	Part transporting device A nut transporting device includes: an outer cylinder, multiple attracting members that are arrayed in a spiral shape about a center axis extending in an axial direction of the outer cylinder, on an inner surface side of the outer cylinder and that form a magnetic field on an outer surface side of the outer cylinder to attract a weld nut to an outer surface of the outer cylinder; a rotary drive unit configured to rotatably move the attracting members about the center axis; and a restriction guide that restricts rotational movement of the weld nut to move the weld nut axially along the outer surface of the outer cylinder.
US12227367B2	Feeding of food products in slicing or portioning machines A food processing machine (10) and a method of cutting slices or portions from a food product (60, 70, 72, 74) in a food processing machine are described. The food processing machine comprises a cutter (30) to cut portions from a food product and a sensing apparatus (43, 45) configured to sense a profile of the food product. The machine is arranged to control sensing and cutting feed rates independently.
US12227366B2	Apparatuses, systems, and methods for process dolly synchronization with assembly line conveyors Methods, systems, and apparatus for a conveyor assembly. The conveyor assembly includes a conveyor, at least one stationary track positioned parallel to the conveyor, a process dolly configured to operatively couple to the at least one stationary track, and a syncing apparatus configured to couple to the process dolly and operatively couple to the conveyor. The syncing apparatus is configured to lock the process dolly in place along the conveyor such that the process dolly moves together with the conveyor with respect to the at least one stationary track.
US12227365B2	Conveyance device A conveyance device 1 that conveys articles, the conveyance device 1 including a circulation path 10 and movable modules 20 that are movable on the circulation path 10. A main container 31 on which an article can be placed and a pair of holding members 311, 312 able to move towards and away from each other are provided to some of the movable modules 20. The article is placed on the main container 31 and conveyed on the circulation path 10 while being held by the pair of holding members 311, 312.
US12227363B2	Platform unit and storage system including the same A platform unit usable to support and move an item, comprising a base; a conveyor mounted to the base and operative for moving the item parallel to the base, the conveyor being pivotable about a pivot axis extending substantially perpendicular to the base; and a controller for selectively activating the conveyor and for selectively pivoting the conveyor about the pivot axis. Also, a storage system including many of the platform units.
US12227362B1	Conveyor idler support structure and methods for constructing the same This invention provides framework for supporting a plurality of conveyor idlers, mounted on central risers and end risers, and a method for constructing the same. A center section comprises, an upper component having a downwardly oriented channel with a sidewalls. It includes a first pair of central riser tabs folded upwardly from the top surface. The center section also comprises a lower component having an upwardly oriented channel with sidewalls. It includes a second pair of central riser tabs folded upwardly from the top surface. The upper component is sized and arranged to nest within the lower component and the first pair of central riser tabs overlap on the second pair of central riser tabs. A pair of end risers are mounted at each opposing ends of the center section, formed from sheet metal, and affixed to the opposing ends of the center section.
US12227361B2	Flat packing belt A flat packing belt includes a front face and a back face. The front face and the back face include same raised oblique-strip patterns, so that an oblique direction, an oblique angle and a distance between adjacent raised oblique-strip patterns of the raised oblique-strip patterns observed from an orthographic projection of the front face are the same as the oblique direction, the oblique angle and the distance between adjacent raised oblique-strip patterns of the raised oblique-strip patterns observed from the orthographic projection of the back face. By designing the same friction patterns on both the front face and the back face of the packing belt in opposite directions. The flat packing belt not only ensures large friction, but also ensures accurate belt moving during the process of manufacture. Therefore, production quality is ensured.
US12227358B1	Automated warehouse order picking An automated system of airborne drones may be equipped with components for navigating within a warehouse environment, locating specific bins of product as assigned, retrieving a single item from the bin, and delivering the retrieved item to a central shipping area or disposing in a designated location including conveyor belts or mobile robotic platforms.
US12227357B2	Order picking method and device, and storage medium The embodiments of the present disclosure relate to an order picking method and device, and a storage medium. The method includes: acquiring at least one piece of order information; acquiring information of at least one storage bin in a circulation box, wherein a plurality of storage bins are arranged in the circulation box; associating the at least one piece of order information with the information of the at least one storage bin, wherein the at least one piece of order information is in one-to-one correspondence with the information of the at least one storage bin; acquiring position information of all commodities, corresponding to the at least one piece of order information, in a commodity warehouse; determining an order picking path according to commodity information and the position information; and moving the circulation box in the commodity warehouse according to the order picking path for completing commodity picking.
US12227356B2	Automated storage and retrieval system A container handling vehicle includes a lower part and an upper part. The lower part includes a width and a length that form a vehicle footprint of the container handling vehicle; and a storage space configured to accommodate a storage container. The lower part includes a first set of wheels oriented in a first vertical plane and a second set of wheels oriented in a second vertical plane orthogonal to the first vertical plane. The lower part includes a first set of vertical side walls that are co-planar to the first vertical plane, and a second set of vertical side walls that are co-planar to the second vertical plane. The first set of wheels, the second set of wheels, the first set of vertical side walls, and the second set of vertical side walls are arranged such that the lower part of the container handling vehicle has a cuboid shape. The upper part is disposed vertically above the lower part, and includes a protruding section and a recessed section. The protruding section is configured to extend beyond the lower part. The recessed section has a shape complimentary to the protruding section such that the recessed section is configured to receive other protruding sections of other container handling vehicles.
US12227353B2	Single use beverage pod A single use beverage pod for use in producing a beverage comprises: a body defining a cavity; a beverage medium contained within the cavity; and a protective barrier coupled to the body and at least partially sealing the beverage medium from a surrounding environment to provide at least one of an oxygen barrier and a moisture barrier, the protective barrier having a dissolvable region that is configured to dissolve during production of the beverage to provide a passageway through the protective barrier. The oxygen barrier and/or moisture barrier provided by the protective barrier can reduce the need for, and/or complexity of, packaging for the beverage pod. The dissolvable region dissolves during production of the beverage, allowing the beverage pod to be used with conventional brewing machines without modification thereof.
US12227352B2	Single-serve beverage pod with additive enclosure and methods of making and using thereof The present disclosure is directed to a single-serve beverage pod having an additive enclosure and methods of making and using the same. The additive enclosure may serve to hold an additive that, when brewing a single-serve beverage, combines with a beverage precursor to yield a beverage infused with the additive. The present disclosure has recognized the difficulty in introducing a precise amount of desired additive in beverages, as well as the possibility of the additive being absorbed by or adversely affecting the beverage precursor, and provides a solution to making and using a single-serve beverage pod with a precise amount of desired additive.
US12227349B2	System and method for providing and assembling an auto-injector A component storage and nest system, the system including a tub having a lip portion provided on an interior surface of the tub; a primary nest having a plurality of receptacles in an upper surface, the upper surface having a flange portion about a perimeter being configured to engage the tub about the lip portion; and a plurality of medical components, a medical component being provided in each of the plurality of receptacles.
US12227331B1	Fishing crate and components, accessories and mounts therefor A crate has an arrangement of fastening holes for mounting crate components, as well as various mounts and accessories to the outer and inner surface of the crate. The fastening holes are blind holes that do not breach, penetrate or pass-through panels defining the crate so that the crate remains watertight or sealed or leakproof. The fastening holes may be arranged to provide points of intersection for rules or guides that define a grid to aid in mounting components, mounts and accessories at desired locations. Outer fastening holes are provided in a repeating pattern and superimposed on inner fastening holes. The fastening holes provide for ease of customization without the need for drilling.
US12227329B2	Stretch-blown plastic container with a handle region made integral and method of production for the plastic container A stretch-blown plastic container, includes a container body which encloses a filling volume with a container bottom; a container neck which adjoins an opposite end of the container body, having a container opening and an integrated handle region, the handle region being hollow and joined to the filling volume which is enclosed by the container body; and between the handle region and the container body, a through opening recessed and bordered over its entire periphery by wall parts of the container body and of the handle region which have been welded to one another.
US12227327B2	Sustainable film pouch machine A pouch machine vertical sealer capable of fusing a pouch film web to form a plurality of spaced vertical seals along a length of the film web to form pouches. The pouch machine vertical sealer includes a sealer wheel rotatable about a vertical axis of rotation and defines a film web path about a periphery of the sealer wheel. The vertical sealer further includes a plurality of vertical sealer land assemblies spaced apart about the periphery of the sealer wheel. Each vertical sealer land assembly includes an impulse heater such that contact between the film web and each impulse heater of the plurality of vertical sealer land assemblies forms the spaced apart vertical seals along the length of the film web.
US12227326B2	Closure strip guide and method A closure strip guide is provided having a front plate, a back plate and a plate keeper. The back plate is carried proximate and spaced from the front plate to provide a gap thickness configured to guide a strip of clips. The plate keeper is configured to retain together the front plate and the back plate to retain the gap thickness to slidably receive and guide the strip of clips. The plate keeper also expands the gap thickness between the front plate and the back plate responsive to a stack-up jam to accommodate multiple layers of clips in the event the strip of clips dislodges and/or jams. A bag closing apparatus and a method are also provided.
US12227322B2	Draft handler system The invention relates to a draft handler. The draft handler has a tool stem adapter for coupling to a robotic arm, and has a spatula for lifting a draft product and an elastomeric band for gripping the draft product. The robotic arm moves the draft handler to pick up the draft product in a first orientation from a first conveyor assembly, and to place the draft product on a second conveyor assembly, optionally in a second orientation.
US12227321B2	Transporting apparatus for packing machine A transporting apparatus for a packing machine has a mounting base, a weighing mechanism, a raising mechanism, a transmitting mechanism, and a lifting mechanism. The raising mechanism has a raising driver and a raising frame being drivable by the raising driver. The lifting mechanism has a lifting driver and a lifting frame being drivable by the lifting driver. The transmitting mechanism has a transmitting driver and a transmitting frame being drivable by the transmitting driver. The weighing mechanism, the raising mechanism, the transmitting mechanism, and the lifting mechanism are fixed apart on the mounting base, which reduces noises and vibrations during operation and improves convenience of mounting and detaching.
US12227318B1	Aerial vehicles with proximity sensors for safety An aerial vehicle or another system having moving components may be configured with a capacitive sensing system for detecting body parts of humans or other animals within proximity. The capacitive sensing system includes conductive components provided in association with surfaces of housings within which motors rotate propellers or other objects. The capacitors are coupled to circuits including transistors, resistors, capacitors or other features that are configured to determine levels of capacitance on the conductive components during operations of the aerial vehicle or other system. When a body part approaches a conductive component, and disrupts a level of capacitance on a capacitor coupled to the conductive component, a change in the level of capacitance on the capacitor is detected. Where the change exceeds a predetermined threshold, predetermined actions such as stopping or otherwise altering operations of the motors may be performed.
US12227317B2	Systems and methods for a spring-augmented quadrotor for interactions with constrained environments Various embodiments of a variable geometry quadrotor with a compliant frame are disclosed, which adapts to tight spaces and obstacles by way of passive rotation of its arms.
US12227313B2	Fold-out satellite with integrated radiator panel A satellite includes a first radiator panel with first heat-generating components attached to its surface and a second radiator panel with second heat-generating components attached to its surface. One or more actuators are configured to deploy the first and second radiator panels from a compact configuration in which the first and second radiator panels are overlapping to a deployed configuration in which the first and second radiator panels are non-overlapping.
US12227312B2	System and method for thermal control of powered systems on-board a flight vehicle using phase change materials (PCMs) Thermal control of powered systems on-board a flight vehicle is achieved by leveraging the latent heat storage capacity of Phase Change Materials (PCMs) to maintain the operating temperature at or slightly above the melting temperature of the PCM.
US12227311B2	Anti-gravity drive An apparatus comprised of positionally directable masses attached to a binding component that includes a coupling device for payload to reduce gravitational deviation of the apparatus' trajectory by alternatingly accelerating and retracting physically bound component masses in equal and opposite directions to the extents of their bindings, initially and optimally perpendicular to the gravitational field and perpendicular to the apparatus trajectory by using in built transduction componentry located within the masses or the binding componentry or both that utilises electromagnetic forces, forces generated by chemical reactions, or other applied or responsive motive force to positionally direct the bound directable masses.
US12227307B2	Predictive maintenance model design system A data processing system for generating predictive maintenance models is disclosed, including one or more processors, a memory, and a plurality of instructions stored in the memory. The instructions are executable to receive a historical dataset relating to each of a plurality of systems, including maintenance data and operational data. The instructions are further executable to display one or more algorithm templates and one or more data features calculated from the operational data, in a graphical user interface. The instructions are further executable to receive a selection of an algorithm template, a data feature, and a value of a parameter associated with the algorithm template, and to train and evaluate the selected algorithm template on the selected data feature according to the received value. The instructions are further executable to display a result of a metric of the evaluation, and generate a predictive maintenance model using the selected algorithm template.
US12227306B2	Flying vehicle systems and methods An unmanned aerial vehicle according to certain embodiments generally includes a chassis, a power supply mounted to the chassis, a control system operable to receive power from the power supply, at least one rotor operable to generate lift under control of the control system, and a winch mounted to the chassis. The winch includes a reel and a motor. The reel has a line wound thereon, the line having a free end. The reel includes a circumferential channel in which a wound portion of the line is wound onto the reel. The circumferential channel includes an inner portion, an outer portion, and a passage connecting the inner portion and the outer portion. The motor is operable to rotate the reel under control of the control system to thereby cause the line to wind onto and off of the reel, thereby causing the free end of the line to raise and lower.
US12227304B2	Method of automated undocking a passenger boarding bridge from an aircraft A method for automatically undocking a passenger boarding bridge that is located in a docked position at a door of an aircraft, includes detecting a start signal to start the undocking procedure, confirming safety conditions, and automatically moving the passenger boarding bridge from the docking position to a parking position.
US12227301B2	Adjustable motor fairings for aerial vehicles Systems and methods to reduce aerodynamic drag and/or affect flight characteristics of an aerial vehicle may include adjustable fairings associated with one or more components of the aerial vehicle. The adjustable fairings may be coupled to and at least partially surround a motor, propulsion mechanism, motor arm, strut, or other component of an aerial vehicle. In addition, the adjustable fairings may be passively movable between two or more positions responsive to airflow around the fairings, and/or the adjustable fairings may be actively moved between two more positions to affect flight characteristics. Further, the adjustable fairings may include actuatable elements to alter a portion of an outer surface of the fairings to thereby affect flight characteristics. In this manner, adjustable fairings associated with various components of an aerial vehicle may reduce aerodynamic drag and/or may improve control and safety of an aerial vehicle.
US12227294B2	Inflatable personal restraint systems An electronic module assembly (EMA) for use in controlling one or more personal restraint systems. A programmed processor within the EMA is configured to determine when a personal restraint system associated with each seat in a vehicle should be deployed. In addition, the programmed processor is configured to perform a diagnostic self-test to determine if the EMA and the personal restraint systems are operational. In one embodiment, results of the diagnostic self-test routine are displayed on a display included on the electronic module assembly. In an alternative embodiment, the results of the diagnostic self-test routine are transmitted via a wireless transceiver to a remote device. The remote device can include a wireless interrogator or can be a remote computer system such as a cabin management computer system.
US12227293B2	Adjustable friction slider assembly for passenger seat Described is an adjustable friction slider assembly having a rail member and a carriage assembly moveably coupled to the rail member, the carriage assembly having a bracket member and a plurality of roller elements moveably coupled to the rail member and coupled to the bracket member using a plurality of attachment members, the plurality of roller elements comprising at least one adjustable roller element coupled to the bracket member using a moveable attachment member, wherein moving the moveable attachment member adjusts a friction between the plurality of roller elements and the rail member.
US12227292B1	System and apparatus for a high-power microwave sensor using an unmanned aerial vehicle Systems and apparatus are provided for a high-power microwave sensor using an unmanned aerial vehicle. The unmanned aerial vehicle may include a central body, at least one electric motor, and a barometric pressure feedthrough. The central body may include a first enclosure housing a plurality of low voltage components, a voltage feedthrough connector, and a second enclosure housing a plurality of high voltage components. The low voltage components may include a first signal processing system, a first radio transceiver, a flight controller, a second signal processing system, a second radio transceiver, and a navigation system. The high voltage components may include a plurality of electronic speed controllers, a power distribution module, an input power interface, and a plurality of high power filters. The components of each enclosure may be segregated such that the high voltage components do not create electromagnetic interference with the low voltage components.
US12227289B2	Rotorcraft provided with an airframe carried by a skid landing gear with zones for taking up variable forces A rotorcraft provided with a rotary wing and a skid landing gear, the landing gear being provided with a first skid and a second skid and with a first cross-member and a second cross-member. The first cross-member is connected to an airframe of the rotorcraft only by two fastenings. The second cross-member is only carried during flight by two supports fastened to the airframe and traversed by the second cross-member. Each support comprises a hole delimited by a stop surface, the second cross-member always being separated from each stop surface by a clearance. A median supporting member is arranged transversely between the two supports and above the second cross-member.
US12227287B2	Landing gear with retractable rocker arm provided with an electric motor and aircraft provided with at least one such landing gear A retractable landing gear for an aircraft. The landing gear comprises a rocker arm hinged to a structure of the aircraft and carrying at least one wheel that is able to move between a deployed position and a retracted position, a shock-absorber hinged to the structure, a connecting rod connecting the rocker arm and the shock-absorber, a strut provided with two connecting links that are hinged to each other and respectively hinged to shock-absorber and connected to an actuator fastened to the structure. The connecting rod is out of alignment with the shock-absorber when a force applied to the shock-absorber is less than a predetermined force, and the landing gear comprises a locking device provided with an elastic return member and a stop device for locking the strut when the wheel is in the deployed position, and then for securing the wheel in the deployed position.
US12227279B2	Electric marine propulsion system and control method A method of controlling an electric marine propulsion system configured to propel a marine vessel includes receiving a user-set distance, identifying a battery charge level of a power storage system on a marine vessel and identifying an energy utilization value. An output limit is then determined based on a remaining distance, the battery charge level, and the energy utilization value. The propulsion system is then automatically controlled so as to not exceed the output limit, enabling the marine vessel to travel the user-set distance without recharging the power storage system.
US12227278B1	Transom bracket assembly having vibration isolation An outboard marine propulsion assembly includes a marine drive having a supporting frame and a steering arm extending from the supporting frame, a transom bracket assembly, a swivel member seated in the transom bracket assembly, the swivel member being configured so that rotation of the steering arm relative to the transom bracket assembly rotates the swivel member relative to the transom bracket assembly to thereby steer the marine drive, an upper vibration isolating joint which couples the steering arm to the supporting frame, and a lower vibration isolating joint which couples the swivel member to the supporting frame.
US12227277B2	Marine propulsion device, propeller unit, and method A marine propulsion device includes a propeller, a propeller shaft, a bushing, a damper, and a spacer. The propeller shaft supports the propeller. The bushing is between the propeller and the propeller shaft and is unitarily rotatable with the propeller shaft. The damper is fixed to the bushing to transmit rotation of the propeller shaft to the propeller. The spacer is spaced apart from the propeller in a back-and-forth direction in front of the bushing to position the bushing in place with respect to the propeller shaft.
US12227275B2	Self-inflating water rescue device A self-inflating water rescue device (1) consisting of a belt (2) for fastening to the waist and a lifebelt (5) connected to a compressed gas cartridge (4) attached to an opening trigger (3), the belt (2) and the lifebelt (5) being connected to each other by a safety strap (9), one end of a release cord (11) is connected to the opening trigger (3), the other end of the cord (11) being routed outside the lifesaving device (1), the lifebelt (5) being provided with a release valve (12) where applicable, and characterized by that a storage pocket (8) is formed on at least a part of the outer side of the belt (2) by a fixed wall (6) and an sliding (loose) wall (7), the lifebelt (5) being arranged in the storage pocket (case) (8), the outer part of the belt (2) being itself a fixed wall (6) of the pocket (8), the lifebelt (5) has a basically interrupted perimeter circle shape, the ends (13) of which at the interruption are overlapping when filled with gas, and when not filled with gas the lifebelt (5) is folded into the pocket (8) in an accordion/fan-like manner.
US12227274B2	Unmanned aerial vehicle search and rescue system A search and rescue drone system includes a buoyant body member, a frame attached to the buoyant body member for carrying a motor and propeller, and an electronic array including a camera, GPS, an EPIRB radio distress beacon, and a transmitter/receiver for remote control flying the drone and communicating with an operator. A laser guidance system may provide coordinates for landing near a swimmer in distress. The search and rescue drone may also be programmed to simply fly to the location of an electronic wearable device, like a bracelet, that is worn by a man overboard. In another embodiment, the search and rescue drone includes pivoting motor mounts, so that it can take off and land vertically with propellers rotating in a horizontal plane, and then the propellers may pivot to rotate in a vertical plane for propulsion across water similar to a fan boat with rescued people aboard.
US12227268B1	Convertible seating for boats A convertible seating apparatus for a boat has a base, a seat, and a backrest coupled to the seat. The seat and backrest are positionable relative to the base into and between a seating position in which the backrest extends transversely upwardly relative to the seat and a lounge position in which the backrest and seat are substantially aligned. A primary locking device is movable into and between a locked position in which the seat and backrest are coupled to the base so as to lock the seat and backrest in the lounge position, and an unlocked position in which the seat and backrest are decoupled from the base so as to permit movement of the seat and backrest into and between the seating position and the lounge position.
US12227265B2	Surface/submersible craft A surface/submersible water-craft, comprising: a hull, means for submerged propulsion provided in or on the hull, means for surface propulsion provided in or on the hull, floodable-on-submerging crew accommodation provided in the hull and a canopy arranged for closing the floodable crew accommodation for protecting the crew from water flow past the craft, the canopy being openable for crew exit from the craft whilst submerged at a destination.
US12227258B2	Foldable personal vehicle A foldable personal such as a tricycle which can be convertible into a stroller, is configured for accommodating a child therein and for preventing, when desired, the child from being able to steer the vehicle, vehicle having an operational state and a storage state, in which it can take an extremely compact form. The vehicle has a longitudinal axis lying in its vertical plane of symmetry and having a horizontal reference plane perpendicular to the plane of symmetry, and it takes its compact form in the storage state both in the direction along its longitudinal axis and in the directions perpendicular to this axis both along the plane of symmetry and perpendicular to the plane of symmetry.
US12227256B2	Bag for motorcycles The bag for motorcycles comprises at least one closing element (2) for closing the bag (1) and a plate (3) that includes at least one housing (4) for housing said at least one closing element (2), and at least one stop element (5) that is movable between a releasing position and a retaining position, so that in the releasing position the at least one closing element (2) can be removed from the at least one housing (4) and in the retaining position the at least one closing element (2) is prevented to be removed from the at least one housing (4).It permits to provide a bag for motorcycles that provides an enhanced security, permitting to fix the bag to the motorcycle in a secure way and also closing the bag for prevent or reduce the risk of an unauthorized access to the bag.
US12227255B2	Closure device for connecting two assemblies to one another Provided is a closure device for connecting two assemblies to one another. The closure device includes a first closure part which has a locking piece with a first locking section and a first magnetic element, a second closure part which has a second locking section and a second magnetic element, and an arresting mechanism which is arranged on the second closure part and which has an arresting element and an actuating mechanism operatively connected to the arresting element. The arresting element can be brought into operative connection with the locking piece in the closed position, in order to lock the positively locked engagement between the first locking section and the second locking section. The actuating mechanism may be actuated in order to adjust the arresting element relative to the locking receptacle so that the first locking section and the second locking section are releasable from one another.
US12227251B2	Harness protector The present disclosure is directed to embodiments of harnesses for supporting and improving comfort of a bicyclist while riding a bicycle. In at least one embodiment, the harness includes a support portion, which supports and contacts hips or a waist of the bicyclist, and a saddle contact portion, which supports and contacts a gluteus maximus (i.e., posterior, rear, butt, etc.) of the bicyclist. The saddle contact portion raises or suspends a perineum area (e.g., an area between the anus and the vulva or scrotum of an individual) of the bicyclist (i.e., rider, operator, user, etc.) above the saddle of the bicycle such that the perineum area does not contact the saddle of the bicycle while riding the bicycle. The harness is adjustable by a plurality of adjustable straps that are coupled between the support and the saddle contact portion. The harness is further adjustable by loosening a locking component interlocking with a toothed member of the support portion, which allows the support portion to be moved from various positions. The bicyclist wears the harness over their external clothing (e.g., pants, shorts, shirt, jacket, etc.).
US12227248B2	Method for protecting components of a steer-by-wire steering system, and steer-by-wire steering system A method is disclosed for protecting the components of a steer-by-wire steering system, where the steer-by-wire steering system comprises a self-locking spindle drive in which the spindle is displaced linearly by driving a positionally fixed spindle nut in rotation. As a function of the speed of the vehicle, the linear displacement of the spindle relative to the spindle nut is summed continuously with respect to time until a first threshold value has been reached. A control unit, a non-transitory computer-readable storage medium, and a steer-by-wire system are also disclosed.
US12227247B2	Apparatus for supporting vehicle body during assembly An apparatus for supporting a vehicle body during assembly includes a support frame, at least one first vehicle body supporting portion installed on a front portion of the support frame to be movable in a vehicle width direction, at least one first position adjustment unit installed on the front portion of the support frame and configured to manually vary a position of a corresponding first vehicle body supporting portion, at least one second vehicle body supporting portion installed on a rear portion of the support frame to be capable of clamping, and at least one second position adjustment unit installed on the rear portion of the support frame and configured to manually vary a position in a vehicle length direction of a corresponding second vehicle body supporting portion.
US12227246B2	Method and processing station for connecting components of a vehicle body The present disclosure relates to a processing station and to a method for connecting a first component to a second component in a processing station, wherein a workpiece holder is moved into a geometry clamping station of the processing station, wherein a clamping jig of the processing station in a first movement, and the workpiece holder moved into the geometry clamping station in a second movement, are simultaneously moved in each case from a preliminary position (PS1, PW1) to a connecting position (P2) in which the first component is connected to the second component.
US12227242B2	Modular vehicle power source storage Vehicles and systems for modular power source storage. A vehicle may include a power source detachable from the vehicle. The power source may supply power to the vehicle and a remote device. The vehicle may further include a cargo bed that stores the power source. The cargo bed or a portion of the cargo bed may be removable from rest of the vehicle along with the power source.
US12227241B2	Method and apparatus for lateral control of vehicle, storage medium and vehicle A method for lateral control of a vehicle includes: determining a target steering wheel rotation angle based on a target trajectory of the vehicle and a vehicle pose; determining a steering wheel rotation angle compensation according to the target steering wheel rotation angle and steering data of the vehicle; and controlling steering of the vehicle according to the target steering wheel rotation angle and the steering wheel rotation angle compensation, such that an actual steering angle of the vehicle is consistent with the target steering wheel rotation angle.
US12227239B2	Steering control device, and steering control method A steering control device is configured to control steering of a vehicle by a steering actuator. The steering control includes a trajectory following control unit and an angle following control unit. The trajectory following control unit is configured to adjust a target angle of a steering angle given to a tire of the vehicle by a trajectory following control that causes a state quantity containing a position of the vehicle to follow a target trajectory. The angle following control unit is configured to adjust an instruction value that is given to the steering actuator and corresponds to an actual angle of the steering angle by an angle following control that causes the actual angle to follow the target angle. The trajectory following control unit is configured to forcibly set the target angle to be a fixed angle in a stop control period.
US12227235B2	Stall thermal protection for force feedback actuator A method includes receiving motor velocity data, and, in response to a determination that the motor velocity data indicates that a velocity of a motor is below a threshold velocity: calculating a thermal metric corresponding to a phase imbalance of the motor; identifying at least one thermal mitigation parameter based on the thermal metric; generating at least one thermal management motor position command based on the at least one thermal mitigation parameter; and selectively controlling the motor according to the thermal management motor position command.
US12227233B2	Steering control method of redundant steering system A steering control method for a redundant steering system. The method includes: receiving, by a first steering controller and a second steering controller, a first command signal and a second command signal, respectively; and synchronizing control outputs of the first steering controller and the second steering controller in a way that at least one of the first steering controller and the second steering controller compensates a control timing according to the first command signal and the second command signal so that the control outputs are synchronized.
US12227231B2	Air guides for vehicles An air guide for a vehicle having a pair of side members. The air guide includes a base member having a pair of opposing ends and a pair of attachment members configured to be coupled to the pair of side members. Each of the pair of attachment members are coupled to a respective opposing end of the base member for movement between a folded position, an unfolded position, and an attachment position between the folded position and the unfolded position.
US12227229B2	Electric-vehicle-body structure including a motor on a vehicle front side To decrease the retraction amount of a traveling motor at front collision. A vehicle-body structure includes a floor panel constituting a floor of an occupant space including a seat on which a passenger sits, a center frame disposed to be higher than and away from the floor panel at a vehicle-width-direction central portion of the occupant space and extending in a vehicle front-rear direction, and a connecting member extending upward from the floor panel, having an upper portion fixed to the center frame, and connecting the center frame to the floor panel. A traveling motor is arranged on a vehicle front side of the connecting member.
US12227227B2	Modular motor vehicle platforms and assembly methods A modular vehicle assembly platform is disclosed. In some embodiments, the platform may comprise a cast bulkhead, a cast cowl, one or more cast front strut towers, a front subframe, a cross-car beam, one or more door rings, a structural central floor comprising a battery, a cast structural rear floor, a cast upper rear section (or d-ring), and a rear motor cradle. The platform may allow for the use of common parts and structure across different vehicle types.
US12227224B2	Externally translating, internally telescoping steering column assembly An axially adjustable steering column assembly includes an upper jacket. And a lower jacket. The steering column assembly further includes a column mounting bracket, wherein the lower jacket is operatively coupled to the column mounting bracket and translates relative to the column mounting bracket, wherein the column mounting bracket defines a first set of tapered rail slots, each of the first set of tapered rail slots disposed on opposite sides of the column mounting bracket and extending longitudinally along the column mounting bracket, wherein the lower jacket defines a second set of tapered rail slots, each of the second set of tapered rail slots disposed on opposite sides of the lower jacket and extending longitudinally along the lower jacket. The steering column assembly yet further includes a first pair of sliding wedge bushings disposed within the first set of tapered rail slots.
US12227217B1	Cart for moving and storing folding tables A table cart for holding and carrying folding tables includes a base and a table rack having at least one horizontal member. The base includes two parallel supports for receiving the bottom edges of folding tables. The table rack is mounted to the base and has at least one upright member and at least one horizontal member that is mounted at the top of the upright member. The at least one horizontal member includes a plurality of tabs that are slidably and frictionally mounted to the at least one horizontal member so that they are able to be manually urged between a first raised, position suitable for permitting the upper edge of a folding table to pass below the tab, and a second, lowered position such that the lower end of the tab blocks the passage of upper edge of a folding table thereby preventing the racked table from tipping.
US12227210B1	Disengagement of an autonomous driving mode based on vehicle operating conditions Disengagement of an autonomous driving mode based on vehicle operating conditions, including: receiving, from a steering torque sensor, torque sensor data indicating an amount of torque applied to a steering system of an autonomous vehicle; determining a predicted torque based on one or more motion attributes of the steering system of the autonomous vehicle; determining an estimated operator-provided torque as a differential between the predicted torque and the amount of torque; selecting a threshold from a plurality of thresholds, wherein each threshold of the plurality of thresholds corresponds to a different possible operating condition of the autonomous vehicle; and disengaging an autonomous driving mode of the autonomous vehicle based on the differential exceeding the threshold.
US12227209B1	Normalized object occupancy determination Techniques for accurately predicting and avoiding collisions with objects detected in an environment of a vehicle are discussed herein. A vehicle safety system can implement one or more models to output data indicating an intersection probability between the object and a portion of the vehicle in the future. The model may employ a blur filter to modify a representation of an object usable to determine the intersection probability. A vehicle can be controlled in an environment based at least in part on the intersection probability.
US12227208B2	Collision imminent detection Systems and methods for collision imminent detection are provided. A method includes collecting sensor data generated by one or more sensors of a vehicle; detecting, by a fallback control system of the vehicle based on the sensor data, an imminent collision between the vehicle and an object in an environment of the vehicle using a first process different from a second process of a primary control system of the vehicle, wherein the first process and the second process are associated with at least one of a perception or a prediction; and transmitting, by the fallback control system to the primary control system, an indication of the detected imminent collision.
US12227196B2	Vehicle control and task processing method and apparatus, computing device and system The present application discloses a vehicle control and task processing method and apparatus, a computing device and a system. The vehicle control method comprises: acquiring a driving control task to be executed and target parameters associated with the driving control task; and executing a corresponding algorithm based on the target parameters to enable a driving control system to complete the driving control task. Through the above-mentioned technical solution, accurate vehicle parameters are acquired according to the driving control task, thereby improving the reliability of driving control.
US12227192B2	Apparatus and method for controlling steering wheel of autonomous vehicle An apparatus and a method are configured to control a steering wheel of an autonomous driving vehicle. A state of a driver may be monitored during autonomous driving, and at least one of an upward/downward location, a leftward/rightward tilting angle, or an axial movement of the steering wheel of the autonomous driving vehicle may be controlled based on the state of the driver. As a result, danger information may be delivered to the driver through a dual system during autonomous driving.
US12227191B2	Iterative method for estimating the movement of a material body by generating a filtered movement grid The invention relates to an iterative method for estimating the movement of at least one material body in a surrounding space discretized into a grid of cells that includes: a) obtaining an inconsistency grid in iteration t, generated in response to detection of a change of occupancy state in at least one of the cells of the grid of cells between an iteration t-1 and iteration t, b) recurrently generating a filtered movement grid in iteration t, the filtered movement grid in iteration t being generated on the basis of the filtered movement grid in iteration t-1 of an inconsistency grid from iteration t-1 and of the inconsistency grid in iteration t.
US12227188B2	Dynamic slip target traction control Systems and methods to automatically detect and respond to driving on a deformable surface are provided. A system can determine, for a first time interval, a difference between an expected acceleration of a vehicle and an actual acceleration of the vehicle measured via one or more sensors of the vehicle. The system can detect, for the first time interval, a condition for the vehicle to increase a first slip target set for the vehicle. The system can increase the first slip target set for the vehicle to a second slip target responsive to the difference greater than or equal to a threshold and the detection of the condition.
US12227186B2	Interaction auto-labeling using spatial overlap of track footprints for mining interactions Apparatus and methods of the present disclosure provide a solution to quickly sort through and identify relevant data sets from large amounts of data collected by numerous vehicles. This process is a form of data mining where a processor executes instructions out of a memory to evaluate sensor data collected by vehicles over time. These vehicles may be driven by person's such that data collected by those sensors would be representative of how a person drives. After data has been acquired, it may be evaluated to identify portions of data where one vehicle encounters another vehicle along a roadway. Data may be classified as being associated with particular types of driving maneuvers and organized into data sets with labels consistent with the classification or driving maneuver. Classifications could correspond to different typed of driving maneuvers, “turning left across traffic,” “all way stop,” “merging onto a highway,” or “lane change”.
US12227184B1	Vehicle gear selection control A motor vehicle for operation by a driver has a frame with wheels and a motor connected to the frame. A steering control is connected to the wheels to establish a steering angle.A controller is operably connected to the steering control, to the motor, and to the wheels, and is operable to selectably drive the wheels in a forward direction in a drive mode and in a rearward direction in a reverse mode. The controller is operable to select a direction for driving the wheels in response to a pattern of steering angle movements, without operator indication of a direction.
US12227180B2	Driving support device, driving support method, and driving support program A driving support device acquires a signal color and controls a vehicle speed. The device controls the vehicle before a recognizable point such that a vehicle speed at a time at which the vehicle reaches the recognizable point is equal to or lower than a target value which is a lower speed than a target value. The recognizable point is a point at which a distance to the nearest traffic light positioned in front of the vehicle is a predetermined value. The device controls the vehicle such that, when a signal color of the traffic light is green, and a distance between the traffic light and a next traffic light is equal to or shorter than a predetermined threshold value, the vehicle travels at a constant speed equal to or lower than the target value until the signal color of the next traffic light is acquired.
US12227178B2	Vehicle control device, vehicle control method, and storage medium A vehicle control device according to an embodiment includes an imager configured to image surroundings of a host vehicle, a recognizer configured to recognize a surroundings situation of the host vehicle, a driving controller configured to control one or both of speed and steering of the host vehicle on the basis of a result of the recognition of the recognizer, and a controller configured to control the driving controller on the basis of imaging content of the imager, and the controller sets relative position information with respect to the host vehicle for an object around the host vehicle present on a two-dimensional image captured by the imager, and corrects the recognition result of the recognizer on the basis of the set relative position information.
US12227177B2	Vehicle control device and vehicle control method There are included an own vehicle position sensor which detects the position of an own vehicle; a reference path acquisition unit which acquires a reference path on which the own vehicle travels; a reference path determination unit which determines whether or not the own vehicle is traveling on the reference path; a temporary vehicle path calculation unit which, when it is determined by the reference path determination unit that the own vehicle is not traveling on the reference path, calculates a temporary vehicle path from at least two points, a travel start point of the own vehicle and an end point of the reference path; and a vehicle path setting unit which sets either the temporary vehicle path calculated by the temporary vehicle path calculation unit or the reference path on which it is determined by the reference path determination unit that the own vehicle is traveling as the vehicle path of the own vehicle.
US12227176B2	Transport-related object avoidance An example operation includes one or more of determining, by a transport, a potential impact with an object at a location in a lane on a road and, when a distance away from the location exists within the lane, maneuvering, by the transport, the distance within the lane to avoid the potential impact.
US12227175B2	Autonomous vehicle maneuvering based upon risk associated with occluded regions An autonomous vehicle (AV) is described herein. The AV is configured to identify an occluded region where a portion of a field of view of a sensor is occluded by an object. The AV is further configured to hypothesize that an object exists in the occluded region and is moving in the occluded region. The AV is still further configured to perform a driving maneuver based upon the hypothesized object existing in the occluded region.
US12227166B2	Hybrid propulsion system power management An example method of managing power in a hybrid propulsion system includes receiving, by one or more processors, a power demand that specifies an amount of power to be used to propel a vehicle that includes an electrical energy storage system (ESS) and one or more electrical generators, wherein the one or more electrical generators are configured to convert mechanical energy to electrical energy; determining, based on the power demand and a predetermined ESS output limit, a first amount of power to be sourced from the ESS and a second amount of power to be sourced from the one or more generators; and causing, by the one or more processors, the ESS to output the first amount of power onto a direct current (DC) electrical distribution bus and the one or more generators to output the second amount of power onto the DC electrical distribution bus.
US12227162B2	Motor driving circuit for electronic parking brake system The present disclosure relates to a motor driving circuit of an electronic parking brake system, which is configured to include a first motor and a second motor for releasing or applying a parking brake applied to different wheels, respectively; and a first ECU and a second ECU for controlling the driving of the first motor and the second motor, respectively, wherein the second ECU is prevented from intervening in the driving of the first motor and the second motor while the first ECU drives the first motor and the second motor, and controls the driving of the first motor and the second motor only when there is an abnormality in the first ECU.
US12227160B2	Apparatus, method, and computer program for scheduling transmissions A method may include, by an apparatus, sensing at least one beam; initiating a channel occupancy time based on the sensing; transmitting at least one first downlink transmission on the at least one beam during the channel occupancy time, wherein the at least one first downlink transmission on the at least one beam triggers at least one first uplink transmission on the at least one beam during the channel occupancy time; receiving the at least one first uplink transmission on the at least one beam during the channel occupancy time; determining interference condition on the at least one beam based on the at least one first uplink transmission; and scheduling at least one second downlink transmission or at least one second uplink transmission on the at least one beam with restriction during a rest of the channel occupancy time when the interference condition meets at least one threshold requirement.
US12227156B2	Vehicle brake control device and vehicle brake control method A brake controller includes: a necessary braking force calculator to calculate a necessary braking force that is a braking force generated by a mechanical brake apparatus in order to obtain a deceleration indicated by a brake command; an initial speed acquirer to acquires an initial speed; a target pressing force calculator to calculate a target pressing force that is a force for pressing a brake shoe against a wheel in order to obtain the necessary braking force; and a target pressure calculator to calculate a target pressure indicating a pressure of a fluid inside the brake cylinder that is necessary for obtaining the target pressing force and perform feedback control to adjust the target pressure based on a feedback signal acquired from a pressure sensor.
US12227155B2	Brake device for vehicle A brake device for a vehicle includes a fluid supply portion that supplies a fluid to a wheel cylinder utilizing the fluid in a reservoir and is configured such that a piston presses brake pads against a disc rotor to apply a braking force to a wheel. The brake device includes: a fluid level sensor configured to measure a value of a fluid level in the reservoir and a controller including one or more processors and configured to: estimate a wear amount of the brake pads based on a result of measurement by the fluid level sensor; estimate a heat generation amount of the brake pads based on the result of measurement; and determine whether a fluid leakage is occurring based on i) an amount of change in the fluid level that is based on the result of the measurement, ii) the wear amount, and iii) the heat generation amount.
US12227152B2	Brake caliper A brake caliper has a fixed seat. The fixed seat has a first brake lining and a second brake lining. The fixed seat further has a first piston and a second piston that can be pushed by hydraulic oil. A movable seat is slidably disposed on the fixed seat. The movable seat has a link portion that can link the first brake lining and a drive unit that can push the second piston mechanically. The first piston and the second piston can be pushed hydraulically to drive the first brake lining and the second brake lining for braking. The drive unit pushes the second piston to drive the second brake lining, and pushes the movable seat to drive the first brake lining for braking.
US12227150B2	Vehicle sensor calibration target alignment system A target alignment system for calibrating a safety sensor mounted on a vehicle with front and rear wheels by locating an optimum target position upon a horizontal surface for accurate calibration of the sensor. The target alignment system comprises a plurality of visual guide projectors and a pair of target assemblies which project a visible guide line perimeter around the vehicle, the perimeter including parallel longitudinal lines on either side of the vehicle, a lateral alignment guide line crossing the longitudinal lines in front of the vehicle, and a center guide line colinear with the vehicle center line. The front and rear wheels of the vehicle are longitudinally aligned causing the vehicle thrust line to match the vehicle center line. One of the visual guide projectors projects a transverse line across the center guide line, creating an intersection point which marks the optimum target position.
US12227148B2	Multi-lever lifting device for vehicle with improved efficiency The present invention relates to a multi-lever lifting device for a vehicle, which is a lifting device mounted on a roof or a cargo loading part of the vehicle so that a cargo may be easily loaded on the roof or the cargo loading part. More particularly, the present invention relates to a lifting device including a lower frame, a multi-lever including a first lever, a second lever, and a third lever, and an upper frame on which a cargo is loaded, and capable of lowering an operation height of the lifting device and reducing a driving torque that is required. According to the present invention, the second lever, the third lever, and the upper frame are located under the first lever during a rotation operation process, so that a height restriction is reduced, and a less acting torque is required.
US12227145B2	Machine security system A work machine comprising a security system for deterring theft is disclosed. The work machine comprises a frame, a battery, a ground engaging element supporting the frame; and a security system configured to activate an at least one anti-theft deterrent when an unauthorized person is detected in a detection zone around the work machine.
US12227139B2	Airbag assembly for liftgate A vehicle includes a vehicle roof and a liftgate pivotable relative to the vehicle roof between an open position and a closed position. The vehicle includes an airbag supported by the liftgate and moveable with the liftgate between the open position and the closed position. A tether is fixed to the airbag and the liftgate. The tether extends from the airbag vehicle-rearward to the liftgate.
US12227138B2	Vehicle seatback having rotatable arm on bolster With reference to the Figures, wherein like numerals indicate like parts throughout the several views, a vehicle includes a vehicle seat that includes a seatback and a seat bottom that defines an occupant seating area. The seatback includes an inboard bolster and an outboard bolster spaced from the inboard bolster in a cross-seat direction with the occupant seating area between the inboard bolster and the outboard bolster. A arm is rotatably supported by the inboard bolster. The vehicle includes a computer that includes a processor and a memory storing instructions executable by the processor to detect an occupant in the occupant seating area and based on the detection of an occupant in the occupant seating area, rotate the arm toward the occupant seating area in response to detection of certain vehicle impacts.
US12227131B2	Vehicle body structure mounted side view mirror A side view mirror assembly includes a base frame configured to couple to a bracket that is connected to a vehicle static structure. The base frame interfacing with the bracket through a guide that is at least partially received within a pocket when the base frame is coupled to the bracket. A mirror housing assembly is adjustably supported by the base frame.
US12227125B1	Logo lamp module, external rear view assembly and motor vehicle The present disclosure relates to a logo lamp module for an external rear view assembly of a motor vehicle comprising a projection optics lens stack arranged within a stack holding portion of a housing closed by a printed circuit board, wherein the projection optics lens stack comprises a logo sheet or image substrate between at least one first lens and at least one second lens, with the at least one first lens being arranged between the printed circuit board and the logo sheet or image substrate, and the at least one second lens being arranged between the logo sheet or image substrate and a light exiting portion of the housing. The logo lamp module further comprises a flow path which is provided by a hole through the printed circuit board and a funnel added to the at least one first lens such that a resin or adhesive applied on the outer surface of the printed circuit board contacts the surface of the logo sheet or image substrate facing the at least one first lens to seal the connection of the printed circuit board and the housing as well as to fix the logo sheet or image substrate within the housing. In addition, the present disclosure relates an external rear view assembly with such a logo lamp module and a motor vehicle with such an external rear view assembly.
US12227124B2	Method for operating a lighting device of a motor vehicle A method for operating a lighting device of a motor vehicle where a front left outer region and a front right outer region of the motor vehicle can be lit with the lighting device. The method includes lighting the front left outer region and additionally the front right outer region when the motor vehicle is traversing a bend to the left and/or lighting the front right outer region and additionally the front left outer region when the motor vehicle is traversing a bend to the right.
US12227120B1	Barrier transfer machine telematic device A telematics device for a barrier transfer machine with machine sensors that capture operational data of the barrier transfer machine associated with a barrier segment includes a processing element, a communication element, and a memory element. The processing element is configured to receive the captured operational data. The communication element is in communication with the processing element and is configured to wirelessly transmit a signal representative of at least a portion of the captured operational data. The memory element is in communication with the processing element and is configured to store at least a portion of the captured operational data.
US12227116B2	Car floor mat The present disclosure provides a car floor mat. The car floor mat includes a wear-resistant layer arranged on an upper surface, an anti-skid layer arranged on a lower surface, a supporting layer and a stable layer stacked between the wear-resistant layer and the anti-skid layer. The wear-resistant layer, the anti-skid layer, the supporting layer and the stable layer are all layer structures having equal thickness, and the adjacent layers are connected by a heat sealing process.
US12227115B2	Flexible heater and method of integration A climate controlled system comprising: a movable member disposed in a recess of a cushion and forming part of an occupant support surface with the cushion; a heater overlaying the cushion and the movable member, the heater including: a flexible substrate, a heating element, and an adhesive layer, wherein the flexible substrate includes adhesive on opposing longitudinal edge regions and the adhesive directly or indirectly connects the heater to the cushion; and wherein the adhesive layer anchors the heater as the flexible substrate stretches or moves with the movable member as the movable member moves.
US12227109B2	Power battery heating system and control method and control circuit thereof The present application provide a control method of a power battery heating system. The method includes: controlling all upper bridge arms of a first bridge arm group and all lower bridge arms of a second bridge arm group to be turned on, and all lower bridge arms of the first bridge arm group and all upper bridge arms of the second bridge arm group to be turned off, so as to form a first loop; controlling all the lower bridge arms of the first bridge arm group and all the upper bridge arms of the second bridge arm group to be turned on, and all the upper bridge arms of the first bridge arm group and all the lower bridge arms of the second bridge arm group to be turned off, so as to form a second loop. The method is used to heat the power battery.
US12227108B2	System and method for energy management of a power pack for an electric vehicle including photovoltaic charging Disclosed herein are systems and methods for energy management. A system, such as a vehicle, includes power packs and a photovoltaic array with interconnected photovoltaic cells that supplies electric charge to the power packs for charging the power packs. A charge management database stores data tracking respective charge cycles of the power packs based on the charging and discharging of the power packs. An energy control system controls flow of power in the system to control the charging and the discharging of the power packs, optimizes the flow of power in the system based on the respective charge cycles as tracked in the data stored in the charge management database, and updates the charge management database based on the optimization(s). An output interface outputs a status of the power packs based on the flow of power, for instance to indicate effect(s) of the optimization(s) on the power packs.
US12227105B2	Method for determining a derating factor, a control unit, a power system and a vehicle A method for determining a derating factor for a rechargeable energy storage system. The derating factor is indicative of the rate at which an electrical load, imparted on said rechargeable energy storage system, is reduced, said rechargeable energy storage system being associated with at least a first load threshold and at least a second load threshold being located further away from a zero electrical load value than the first load threshold. The method includes determining a safety margin value by combining an accumulated first load value and an accumulated second load value and relating the thus combined values with said operating time range, and comparing said safety margin value to at least one safety margin threshold value in order to determine whether or not said derating factor should be modified.
US12227103B1	Energy supply status indication for a vehicle A vehicle provides an indication of status of an energy source that provides power for the vehicle. The vehicle includes an indicator, positioned on the vehicle at a location determined to be among a plurality of locations to most likely be intact during and after an accident. The indicator provides a predetermined indication that identifies status of an energy source that provides power for the vehicle. The indicator may provide a visual or acoustical indication or may provide a wireless message. The indication may provide an indication of one or more of make/model of the vehicle, battery charge level, type, danger condition, danger condition reoccurrence, danger condition suppression technique and a warning to not approach the vehicle.
US12227102B2	Electric vehicle charging management methods and systems Electric vehicle charging management methods and systems are provided. A server performs a charging scheduling operation for each electric vehicle charging station to determine a specific time point for each electric vehicle charging station to perform a charging operation in which the charging operation is to charge an electric vehicle coupled with the electric vehicle charging station. When the charging operation corresponding to each electric vehicle charging station is being performed, each electric vehicle charging station transmits charging information corresponding to the charging operation to the server through a network. The server determines whether the charging operation of specific electric vehicle charging station among the electric vehicle charging stations is abnormal based on the charging information received from each electric vehicle charging station, and generates a warning notification and sends the warning notification through the network when the charging operation of the specific electric vehicle charging station is abnormal.
US12227100B2	Charging control method for electric moving body, and electric moving body A battery consumption amount from when an electric vehicle departs a base charging location to when the electric moving body has returned to the base charging location is set as a consumption amount of one day, and an estimated consumption amount of one day is calculated based on the consumption amounts of the past n days. A value obtained by adding the estimated consumption amount and a margin to a lower limit remaining capacity determined in advance by a user is set as a charging recommendation threshold value. When the remaining capacity of the battery drops below the charging recommendation threshold value, a notification prompting charging of the battery is transmitted to an on-board HMI of the electric moving body or a terminal of the user.
US12227098B2	Automated electric vehicle charging station An automated electric vehicle charging station. The charging station can include a frame to which a vehicle can park in proximity to receive an electric charge. The frame is at least partially underneath the vehicle. The charging station can include an alignment indicator and a charging indicator to alert an occupant of the vehicle to a vehicle alignment status and a vehicle charging status. When the vehicle is parked in a charging position, an electronic charging unit automatically determines a receiving location on the vehicle where the vehicle can receive an electric charge. A charging plug can be stored in the frame and can be actuated out of the frame and travel in multiple directions to the receiving location. Electric charge can then be transferred from the charging plug to the vehicle. When the vehicle is finished charging, the charging plug can be actuated to return to the frame.
US12227094B2	Connector and power supply device Provided is a configuration capable of supplying compressed air to a pneumatic apparatus while supplying electric power to an electric vehicle. A connector is connected to a vehicle provided with an air suspension device to which compressed air is supplied, and supplies electric power supplied from an electric power supply unit to the vehicle. The connector includes a charging connection portion that supplies electric power to the vehicle, and an air supply connection portion that supplies compressed air to the air suspension device.
US12227089B2	Vehicle drive system A vehicle drive system includes a battery, at least one drive motor, inverter circuits, a step-up circuit, and a switch. The inverter circuits are configured to drive the at least one drive motor. The step-up circuit is connected between the battery and the inverter circuits. The switch is configured to switch a connection state of the inverter circuits to the step-up circuit between series connection and parallel connection.
US12227088B2	Systems and methods for adding a contactor at or near an MSD A system may be configured to replace a manual service disconnect (MSD). Some embodiments may: provide a set of batteries that include an MSD; remove the MSD; and install a contactor at the MSD. The replacement may be performed via substantially similar housing previously used by the MSD.
US12227086B2	Active discharge of an electric drive system An electric drive system for a vehicle includes an inverter having at least one phase leg, wherein a first of the phase legs includes a first power switch; an internal voltage supply configured to generate an internal supply voltage regulated with respect to a voltage on a rail and a second voltage, wherein the internal voltage supply is configured to reduce a voltage difference between the internal supply voltage and the second voltage in response to a signal indicating a shut-down or a fault; and a gate drive channel configured to drive the first power switch into conductance by applying the voltage difference between the internal supply voltage and the second voltage between a control terminal and a main terminal of the power switch, gate drive channel configured to continue the driving of the first power switch for a time duration after the signal indicating the shut-down or the fault.
US12227082B2	Vehicle control system A vehicle control system is provided with a motor generator and has a function of, if a vehicle-stop brake fluid pressure at a vehicle stop timing is less a predetermined pressure necessary for holding a vehicle in a stopped state, boosting the vehicle-stop brake fluid pressure to the stop holding fluid pressure or greater to hold the vehicle in the stopped state. The system includes a first calculator, a second calculator, and a vehicle stop controller. The first calculator calculates a target driving force for the vehicle. The second calculator calculates, from the target driving force, a requested driving force for drive control of the motor generator and a requested brake fluid pressure to be used for brake control. The vehicle stop controller performs, at a timing immediately before the vehicle stop timing, a pre-boosting process of increasing the brake fluid pressure to the stop holding fluid pressure or greater.
US12227079B2	Method of controlling torque of vehicle driving device method of controlling torque of a vehicle driving device is provided. The method includes estimating speed of a driving system of a vehicle from vehicle driving information collected from the vehicle and calculating speed difference between actually measured speed of the driving system and the estimated speed of the driving system. A nominal rate limit value is determined according to the vehicle driving information and a required real-time rate correction amount is determined according to the calculated speed difference. A torque command variation is determined based on the determined nominal rate limit value and the determined required real-time rate correction amount. A torque command after correction in a previous control period is corrected by the determined torque command variation to determine a torque command after correction in a current control period.
US12227075B2	Content display device for road vehicle equipped with time measurement system Road vehicle comprising a passenger compartment configured to accommodate a driver and at least one passenger alongside the driver; a vehicle dashboard; a steering wheel; a content display device comprises: a support element hinged in the area of a central portion of the vehicle dashboard, at the front between a driver's seat and a passenger's seat; at least one screen mechanically connected to the support element and configured to be visible to a passenger and/or to a driver while driving; a time measurement system, in particular a chronograph; the vehicle comprises mechanical controls arranged, namely mounted, in the area of the steering to give instructions to the time measurement system.
US12227074B2	Capacitive touch textiles and vehicle applications A vehicle interface system is disclosed. The system includes a conductive textile 100 and circuitry 408. The conductive textile 100 is configured to provide user input information, wherein the user input information is in response to contact with the conductive textile. The circuitry 408 is configured to analyze the user input information, identify a user input based on the user input information, and determine an associated command based on the identified user input.
US12227073B2	Supports for dynamically bendable auto interior display cover materials A display assembly for an automotive interior comprises a dynamically bendable cover panel having first and second panel portions a flexible panel portion connecting the first and second panel portions, a display positioned adjacent the first and second panel portions, and a frame that supports the cover panel and comprises a first frame portion for supporting the first panel portion, a second frame portion for supporting the second panel portion, and a hinge portion coupling the first frame portion and the second frame portion, the hinge portion configured to induce a curvature having smoothly connected arc segments in the flexible panel portion between the first panel portion and the second panel portion when the second frame portion is articulated relative to the first frame portion from a straight position to a deployed position.
US12227072B2	Display control device for vehicle, display method for vehicle, and storage medium A display control device for a vehicle includes a memory; and a processor connected to the memory and is configured to: detect an operation of a steering switch; on the basis of the detected operation, display plural icons corresponding to the steering switch at a display section in a cabin, the plural icons including a first icon representing a first function that is implemented by a short press operation of the steering switch, and a second icon representing a second function that is implemented by a long press operation of the steering switch; and in a case in which the short press operation is detected, display the first icon such that a disposition of the first icon in the display section corresponds to a disposition of the steering switch at a steering wheel, and display the second icon at a different position in the display section from the first icon.
US12227065B2	Traction battery pack protection and load distribution strategies Protection and load distribution strategies are disclosed for electrified vehicle traction battery packs. Exemplary battery protection structures may include a corrugated portion and at least one flat sheet portion that are joined together. The battery protection structure may be integrated as part of an outer enclosure assembly of the traction battery pack or could embody a skid plate design that is a separate structure from the outer enclosure assembly. The battery protection structures may be configured for absorbing and transferring energy during vehicle loading events, thereby minimizing the transfer of loads inside the battery pack where relatively sensitive battery internal components are housed.
US12227064B2	Battery housing for electric vehicles A battery housing for an electric vehicle includes a cover, a body, and a seal. The body is secured to the cover and includes a first edge section and a second edge section secured to and overlapping the first edge section. The seal is engaged with the cover and includes a channel receiving the first and second edge sections of the body. The first and second edge sections of the body are engaged with the seal within the channel.
US12227059B2	Recreational vehicle and trailer window treatment adjustment system A window treatment adjustment assembly is provided that includes a slider having a base movable along a portion of the frame. A handle extends from the base. A pocket is formed in the screen and includes: a pocket frame attached to the screen to form an opening through the screen; a shroud member attached to at least a portion of the pocket frame. The handle of the slider extends through the opening of the pocket and past the shroud member. The base of the slider is in communication with a mechanism that moves the window treatment.
US12227049B1	Decoupling carrier for an electro-hydraulic unit A decoupling carrier for an electro-hydraulic unit for a chassis of a motor vehicle. The decoupling carrier includes (i) at least one damper receptacle, which can be connected to an electro-hydraulic unit in a force-transmitting manner; (ii) a damper body for each damper receptacle; and (iii) a fastening receptacle for the power-transmitting connection to a chassis carrier of a motor vehicle for each damper body. The fastening receptacle includes a receptacle opening for a line carrier.
US12227047B2	Bellows accumulator fixation apparatus for suspension dampers An accumulator for a vehicle suspension damper, which includes an outer shell with an open end that connects to an accumulator port on the damper and a distal end, opposite the open end, which includes an end wall that extends radially inward to a gas charging port. A bellows assembly, which includes an annular bellows wall extending between proximal and distal plates, is positioned inside the outer shell to define a pressurized gas chamber inside the accumulator that is arranged in fluid communication with the gas charging port. The gas charging port includes a stem that extends inwardly from the end wall of the outer shell and the distal plate of the bellows assembly has an inner diameter that is received on the stem. The inner diameter of the distal plate is coupled to the stem of the gas charging port by a fixation component.
US12227045B2	Tandem axle trailer suspension system A trailer including a trailer frame, and a trailer suspension including a first and second suspension assemblies and a pair of axles. Each of the first and second suspension assemblies includes a first spring including first and second spring ends, and a second spring including third and fourth spring ends. The second spring end of the first spring is positioned adjacent to the third spring end of the second spring, and the second and third spring ends are disposed between the first and fourth spring ends. The second spring end is rotatable about a first rotational axis that is fixed relative to the trailer frame. The third spring end is rotatable about a second rotational axis that is fixed relative to the trailer frame. The first spring end and the fourth spring end of the second spring are movable relative to the trailer frame.
US12227044B2	Vehicle wheel and brake disc apparatus A wheel and brake disc apparatus of a vehicle includes a roadway wheel and a brake disc mounted rotatably to the vehicle, the roadway wheel and the brake disc arranged about an axis of rotation. The roadway wheel extends radially in relation to the axis of rotation to a wheel rim configured to hold a tire adapted to operate on a roadway surface. The brake disc is inboard of the roadway wheel and extends radially in relation to the axis of rotation to a brake disc rim. A brake caliper assembly mounted at a fixed location over the brake disc rim is configured to squeeze brake pads against the brake disc. The brake disc rim includes a tread configured to operate on a rail without interference from the brake caliper assembly.
US12227042B2	Method and system for calculating vehicle trailer angle The present disclosure relates to a method for determining the yaw angle of a trailer with respect to the longitudinal axis of a towing vehicle based on at least one feature included in multiple captured images by providing multiple algorithms for calculating at least one angle estimation.
US12227041B2	Powered arm lifter system and method of automating weight distribution A system for powered trailer weight distribution having a hitch mount with a spring bar, and a trailer with a spring bar mount disposed on the trailer and having an initial position relative to the trailer, wherein the spring bar mount is configured to receive and engage the spring bar, and a weight distribution actuator configured and arranged to adjust a position of the spring bar mount relative to the spring bar while engaged with the spring bar, wherein the weight distribution actuator is connected to a power source that provides power to the weight distribution actuator, facilitating the adjustment of the position of the spring bar mount.
US12227040B2	Pneumatic tire for vehicle with reinforcing structure in the lower toric cavity A tire with improved handling having a stiffening structure with a stiffening element extending continuously in the toroidal interior cavity from a crown interface connected to a radially inner face of the crown to a bead interface connected to an axially inner face of the bead. The stiffening structure is distributed circumferentially over the circumference of the tire, the axially outermost stiffening element interface is positioned, with respect to the equatorial plane (XZ), at an axial distance A at most equal to 0.45 times the axial width S, and the radially outermost stiffening element bead interface is positioned, with respect to a radially innermost point (I) of the axially inner face of the bead at a radial distance B at most equal to 0.5 times the radial height H.
US12227036B2	Vehicle tire pressure alert system for paved road and off-road driving conditions A tire pressure monitoring system includes tire pressure sensors installed within vehicle tires, a receiver, an alerting device, an electronic input/output device and an electronic controller. The receiver receives tire pressure signals from the tire pressure sensors, The electronic input/output device provides manual input of instruction and data. The electronic controller is configured to monitor tire pressure and in response to tire pressure in each of vehicle tires achieving a change from a first preset tire pressure to a second preset tire pressure the alerting device is operated to alert a person changing the tire pressure that the change has been achieved. The first preset tire pressure corresponds to paved road driving conditions and the second preset tire pressure corresponds to off-road driving conditions.
US12227030B2	Tire having circumferential tread with reinforced ribs A pneumatic tire includes a pair of sidewalls, a pair of bead portions, and a circumferential tread having a plurality of circumferential ribs and a plurality of circumferential grooves. A reinforcing layer is disposed in at least one of the plurality of circumferential ribs. No part of the reinforcing layer extends directly below a bottom surface of any of the plurality of circumferential grooves. The reinforcing layer has a consistent gauge along its entire lateral width. A top surface of the reinforcing layer is located radially higher than the bottom surface of each of the plurality of circumferential grooves.
US12227029B2	Pneumatic tire A pneumatic tire is provided. An average thickness of an undertread rubber in a center region is greater than that in a shoulder regions, a loss tangent tan δ at 60° C. of the cap tread rubber is higher than that of the undertread rubber, and the ratio CAI/UAI of a cross-sectional area CAI of the cap tread rubber to a cross-sectional area UAI of the undertread rubber is not less than 0.15 and not greater than 0.95 in the center region.
US12227027B2	High-drainage wheel hub unit A wheel hub unit provided with a radially outer ring, which is stationary during use; a radially inner ring, which is rotating during use; at least one row of rolling elements interposed between the radially outer ring and the radially inner ring; and a sealing assembly, which is interposed between the radially outer ring and the radially inner ring. The sealing assembly defines, cooperating with the radially outer ring or with the radially inner ring, a shield of at least one labyrinth seal. The labyrinth seal does not have a circumferential symmetry, but comprises an upper portion and a lower portion with respect to an axis of symmetry (A) of the wheel hub unit and is provided with an angular interruption of the shield formed on its lower portion corresponding to the lower side of the wheel hub unit so as to increase an outflow section thereof from the said labyrinth seal. Thereby, facilitating gravity drainage of contaminants present inside the sealing assembly.
US12227024B2	Writing implement Provided is a writing implement that maximizes the effective area of a viewer portion allowing visual recognition in the writing direction and that facilitates writing at a high level, at the same time. This writing implement is a writing implement A, including for example, a pen tip 20 that feeds ink from a writing implement body 10 and has a viewer portion 33 allowing visual recognition in the writing direction. The pen tip 20 is comprised of, at least, a writing part 25 and a retainer 30 having the viewer portion 33, an ink feeder portion 26 for feeding the ink from the writing implement body 10 to the writing part 25. The minimum width X of the viewer portion 33 is 3.7 mm or greater and a length Y of the viewer portion 33 is 7.4 mm or greater. The ink feeder portion 26 is arranged on one side of the viewer portion 33. Specifically, the ink feeder portion 26 is preferably adapted to be positioned on a near side during writing (on such a side that the pen tip 20 is located on an obtuse angle side of the ink feeder portion 26).
US12227023B2	Knock type direct liquid pen refill assembly and writing pen Disclosed are a knock type direct liquid pen refill assembly and a writing pen. The pen refill assembly comprises an ink cylinder assembly (100), a pen tip (200) and an elastic member (300). An ink guide core (150) is provided in the ink cylinder assembly. The pen tip (200) is arranged at one end of the ink cylinder assembly (100). An ink duct (210) is formed inside and passes through the pen tip (200). A ball member (230) is provided at an ink outlet end of the ink duct (210). The ink guide core (150) partially passes through the ink duct (210), and one end of the ink guide core (150) is abutted against the ball member (230). The elastic member (300) is sleeved at the periphery of the ink guide core (150) and positioned inside the ink duct (210). The elastic member is abutted against the ball member to exert a force, such that the ball member is closely attached to an inner wall of the ink outlet end, the ball member forms sealed contact with the inner wall of the ink outlet, and ink volatilization and leakage are avoided.
US12227022B2	Patterned conductive layer for secure instruments A secure instrument and associated systems and methods of authentication, the secure instrument including a polymer substrate having a first surface and a second surface; an inner layer disposed on or over the first surface of the polymer substrate, the inner layer being a conductive, absorbing, or upconverting layer and including one or more gaps therein; and an opacity layer disposed on or over the inner layer disposed on or over the first surface of the polymer substrate.
US12227021B2	Security document including a transparent window formed in the substrate thereof Examples include a security document having a substrate with a transparent window. In the region of the transparent window, a micro-optical structure including microlenses is arranged on one side of the substrate and a first print image is arranged on the other side of the substrate, opposite the micro-optical structure. A layer covers at least a section of the first print image. The layer allows electromagnetic radiation having a wavelength in the range of 380 nm to 780 nm to pass with a transparency in a range between 10% and 90%. The transparency gradually varies over a planar extension of the layer. A second print image is arranged on the layer in such a way that the second print image, or at least a piece of information contained therein, can be brought into alignment with the micro-optical structure after carrying out a folding process and becomes visible and/or recognizable.
US12227020B2	System and method for precision inking of micro-optic recesses A method for inking a three-dimensional micro-optic structure includes jetting a first volume of a first radiation-curable ink having a first pigment concentration to a first portion of a three-dimensional icon layer, wherein the first portion of the three-dimensional icon layer has a first volumetric fill requirement, jetting a second volume of the first radiation-curable ink to a second portion of the three-dimensional icon layer, wherein the second portion of the three-dimensional icon layer has a second volumetric fill requirement, blading excess radiation-curable ink from the three-dimensional icon layer and radiation curing remaining radiation-curable ink.
US12227017B2	Liner-less label pre-feed system and method A pre-feed system and method for a liner-less label printer includes a drive roller that is configured to peel liner-less labels from a reel and pass print stock comprising the labels to an in-line label printer at a consistent rate. An idler roller disposed in proximity to the drive roller creates a nip for pulling labels from the reel. Label stock is fed to one or more print heads while supported by a support plate comprising projections extending from a planar surface, contacting an adhesive side of the labels. The projections are aligned in rows substantially perpendicular to a travel direction of the moving print stock and in a plurality of columns substantially parallel to the travel direction of the moving print stock, with projections on alternate rows offset from projections on adjacent rows and projections on alternate columns offset from projections on adjacent columns.
US12227013B2	Information processing device, information processing method, and non-transitory computer-readable storage medium storing program An information processing device includes: an acquisition unit acquiring a designated value of a transmittance of one or more layers included in a plurality of layers stacked on each other and printed on a print medium, the plurality of layers including one or two image layers printed to be visible from one side of the print medium and a foundation layer serving as a foundation of the one or two image layers, the one or more layers including the foundation layer; and a decision unit deciding a layer configuration that is a configuration of the foundation layer, based on the designated value acquired by the acquisition unit.
US12227011B2	Print material storage container A print material storage container has: a substrate on which an electric circuit having terminals is provided; a fixing portion on which the substrate can be mounted by re-fixing; and a fixing member that fixes the fixing portion and a non-terminal portion, which is formed by excluding the terminals from the substrate, to each other. The non-terminal portion includes a re-fixed portion, which can be re-fixed to the fixing portion by the fixing member.
US12227010B2	Printing apparatus and maintenance method A technique for suppressing ejection failure at an ejection port, which is caused by reaction of reaction liquid and ink during a wiping operation, is to be provided. Before the ejection port surface, on which the first ejection port array that is capable of ejecting the ink and the second ejection port array that is capable of ejecting the reaction liquid which reacts with the ink are formed, is wiped by the maintenance unit that is capable of receiving the ink and the reaction liquid, ink that does not contribute to printing is ejected to an area of the maintenance unit between an area abutted by the first ejection port array during the wiping and an area abutted by the second ejection port array during the wiping.
US12227007B2	Liquid ejecting apparatus and method for controlling liquid ejecting apparatus A liquid ejecting apparatus is configured to drive a drive element that is driven in accordance with a drive signal for ejecting a plurality of liquid droplets such that the liquid droplets merge together before landing onto a medium. The drive signal includes a plurality of drive waveforms and a first connection waveform that is continuous from a second-to-last drive waveform and continuous to a last drive waveform and along which a potential of the drive signal is kept at a reference level. Pressure changes caused by the contraction waveform of the last drive waveform in a liquid present inside the pressure compartment are larger than pressure changes caused by the contraction waveform of the second-to-last drive waveform in the liquid present inside the pressure compartment. A period of the first connection waveform is 0.8 or more times as long as a natural vibration cycle of the ejecting portion.
US12227006B2	Liquid discharge apparatus and head drive controller A liquid discharge apparatus includes a head including a piezoelectric element and a nozzle, the head configured to drive the piezoelectric element to discharge a liquid from the nozzle, a drive waveform generator configured to generate a drive waveform to be applied to the piezoelectric element of the head, the drive waveform including a non-discharge pulse configured to drive the piezoelectric element to a degree at which the liquid is not discharged from the nozzle, and a discharge pulse applied to the piezoelectric element after the non-discharge pulse, the discharge pulse configured to drive the piezoelectric element to discharge the liquid from the nozzle, a switch between the head and the drive waveform generator, the switch configured to be switched to an ON-state in which the drive waveform passes the switch or to an OFF-state in which the drive waveform does not pass the switch.
US12227002B2	Electronic tag mounts for printer media supply rolls A tag mount for a media supply roll having a hollow cylindrical core includes: a tag mount body including: (i) an inner wall configured to face the core, the inner wall having a retaining surface to engage with the core and affix the tag mount body to the core, (ii) an outer wall opposite the inner wall, and (iii) a carrier surface, distinct from the retaining surface, the carrier surface defined on one of the inner wall and the outer wall; an antenna affixed to the carrier surface; and an integrated circuit coupled with the antenna and configured to store an attribute corresponding to the media supply roll.
US12226991B2	Discoloration resistant fabric A vinyl fabric includes a polymeric film supported on a substrate. The polymeric film is provided from a composition that includes one or more chlorinated resins (particularly PVC), at least one polymeric plasticizer, large amounts of TiO2, and at least one antioxidant. The combination of the plasticizer, titania and antioxidant provides the film, and in turn the fabric, with improved resistance to discoloration, particularly pink staining as results from the presence of chromophores produced by Streptoverticillium reticulum.
US12226990B2	Stitch bonded wipe A wipe structure of stitch bonded construction incorporating at least one inner layer of cellulose tissue disposed in sandwiched relation between a first discontinuous cover layer of spunbonded polypropylene fleece and a second discontinuous cover layer of spunbonded polypropylene fleece such that the inner layer, the first discontinuous cover layer and the second discontinuous cover layer form a stacked composite and a plurality of stitching yarns extending in stitched relation through the stacked composite.
US12226989B2	Abrasion resistant material and manufacturing method An abrasion-resistant material includes a first layer including a first textile material and a second layer including a second textile material. The second layer is arranged on the first layer, wherein the first layer and the second layer are at least partially heat bonded to each other. The first textile material exhibits a first shrinkability and the second textile material exhibits a second shrinkability, wherein the first shrinkability is greater than the second shrinkability, when at least partially heat bonding the first layer and the second layer.
US12226984B2	Transparent composite material as cladding material for architectural features in building construction A composite material may be used as a building material to provide desirable visible aesthetics, such as in a roof or facade. The composite material may include two or more materials, wherein a first material provides desirable qualities for appearance and a second material provides desirable qualities for strength or other characteristics desirable of a building material. Each of the first material and the second material may be transparent, such that the composite material is also transparent. The first material may be Ethylene tetrafluoroethylene (ETFE) and the second material may be Polyethylene terephthalate (PET).
US12226983B2	Multilayer systems and methods of making multilayer systems Methods of making multilayer systems comprising a sealant layer by extruding a coreactive sealant composition are disclosed. The methods can be used to fabricate multilayer systems in which individual layers have different cured properties. Individual layers can also have an inhomogeneous concentration of one or more constituents within a layer. The multilayer systems can be made using three-dimensional printing that facilitate the use of a wide range of coreactive compositions.
US12226980B2	Laminate A laminate for forming a packaging bag, in sequence: a substrate layer; an adhesive layer; and a sealant layer, wherein the sealant layer includes a first polyester film having a crystallinity of 20 to 50% based on a first absorbance at a first wavenumber of 1409 cm−1, a second absorbance at a second wavenumber of 1370 cm−1, a third absorbance at a third wavenumber of 1340 cm−1, a first constant, and a second constant, the first to third absorbances and the first and second constants being determined based on FT-IR analysis, which uses a reflection method, on at least the first polyester film, the crystallinity of the first polyester film being expressed in accordance with the following formulas (1) and (2): I1409=p1×I1340+p2×I1370 . . . (Formula 1) and C=p1×(I1340/I1409)×100 . . . (Formula 2).
US12226979B2	Optical pattern for information acquisition system The present disclosure relates to a laminated glazing having an information acquisition system viewing area formed to have a pattern in optical power.
US12226975B2	Bag making apparatus, bag making method and bag A bag making apparatus and a bag making method make bags. The bag has a first panel part and a first flap part formed by folding a first sheet part, and a second panel part and a second flap part formed by folding a second sheet part. The first and second panel parts face each other. The first and second flap parts are interposed between the first and second panel parts and face each other. An open edge is formed by folded edges of the first and second sheet parts. The bag further comprises adhesive located between the open edge and the engagement tool, interposed between the first and second flap parts and extending across the widths of the first and second sheet parts to peelably adhere the first and second flap parts to each other. Alternatively, the second sheet part may only consists of the second panel part.
US12226973B2	Footwear assembly method with 3D printing Methods and systems are disclosed for apparel assembly using three-dimensional printing directly onto fabric apparel materials. Disclosed is a method and system for direct three-dimensional printing and assembly of an article of apparel, including designing a three-dimensional pattern for printing, positioning at least a portion of the article on a tray in a three-dimensional printing system, the portion being positioned substantially flat on the tray, printing a three-dimensional material directly onto the article using the designed pattern, curing the printed material, and removing the article from the three-dimensional printing system.
US12226966B2	Pultrusion system with cooling stage and method therefor A system for pultruding a beam comprises a pulling mechanism continuously pulling on a preform of yarns including a thermoplastic matrix and fibers, the pulling mechanism being downstream of the system. A pultrusion die has a tapering channel portion heated such that the preform is at a desired low viscosity temperature for resin in the thermoplastic matrix to impregnate the fibers. A cooling tube is at a downstream end of the pultrusion die. A cooling module is spaced from the pultrusion die by the cooling tube, the cooling module to cool the cooling tube before the preform reaches the pulling mechanism, wherein the cooling tube defines a cooling channel. A pultrusion mandrel may be present.
US12226965B2	Structural composite preform wet-out and curing system and apparatus In accordance with one embodiment of the present invention, the invention comprises a continuous structural composite preform wet out system and apparatus which takes as an input pre-formed structural composite structures with a structural foam core, passes these structures through a wetting system which may comprise sprayers, brushes, a die or dies, or other wetting means; applies a cure process such as ultraviolet light, heat, curing agent or other cure method, and produces a completed, cured structural composite structure such as a beam or panel for use in any structure as desired by the user. The improved structural composite wet out system of the invention provides run rate, ease of use, structure efficiency and handling advantages over the pultrusion systems of the prior art by achieving higher production rates, the ability to use light cure resins and the ability to produce composite structures of non-uniform cross-section.
US12226961B2	Preform charges and fixtures therefor A preform charge is formed by forming an assemblage of preforms, wherein preforms in the assemblage are bonded to a neighboring preform such that the preform charge effectively becomes a single unit. The preform charge can then be added to a mold to fabricate a part via compression molding.
US12226950B2	Method of 3D printing a cellular solid A method of printing a cellular solid by direct bubble writing comprises introducing an ink formulation comprising a polymerizable monomer and a gas into a nozzle, which includes a core flow channel radially surrounded by an outer flow channel. The ink formulation is directed into the outer flow channel and the gas is directed into the core flow channel. The ink formulation and the gas are ejected out of the nozzle as a stream of bubbles, where each bubble includes a core comprising the gas and a liquid shell overlying the core that comprises the ink formulation. After ejection, the polymerizable monomer is polymerized to form a solid polymeric shell from the liquid shell, and the bubbles are deposited on a substrate moving relative to the nozzle. Thus, a polymeric cellular solid having a predetermined geometry is printed.
US12226948B2	Devices, assemblies, kits, systems and methods for shaping of elongated elements containing thermoplastic polymers Devices, assemblies, kits, systems and methods for shaping of elongated elements containing thermoplastic polymers are disclosed.
US12226946B2	Device and method for treating hollow bodies A device for treating hollow bodies, comprising at least a nozzle and a circuit for setting a pressurized airflow in circulation, having a valve and a first pressure sensor measuring a first pressure; a control distributor of said valve; a line connecting said distributor to said valve; a control unit with a time measurement component; wherein said device comprises a second pressure sensor situated along said line, measuring a second pressure, and wherein said control unit comprises means that are able to determine a differential between the measurement of the first pressure and the measurement of the second pressure as a function of time. The invention also relates to a corresponding treatment method.
US12226935B2	Screw pump screw rod rubber lining mould and use method thereof A preparation method of a screw pump screw pump screw rod rubber lining mould includes: mixing a high strength wear-resistant material with a binder to obtain a mixed slurry; injecting the mixed slurry into a female die for solidification and taking out to form a screw rod rubber lining mould preform; drying and sintering the screw rod rubber lining mould preform to obtain a screw rod rubber lining mould; immersing the screw rod rubber lining mould into a surface treatment liquid for surface heat treatment to form a wear-resistant layer, and cooling down to obtain a final mould. The high strength wear-resistant material is prepared by using a ZnFe2O4 nano-particle reinforced Ti(C,N)-based metal ceramic composite material; the surface treatment liquid includes an aluminum borosilicate whisker/polyimide composite material solution; the high strength wear-resistant material having good strength, good hardness, good fracture toughness, and good wear resistance is prepared and applied.
US12226932B2	Tool comprising eutectic material, method of making the tool and method of using the tool A molding tool and method for making the molding tool by additive manufacturing is provided. The molding tool includes a tool body having a tooling surface for molding a part, the tool body comprising a eutectic alloy. The method for making the molding tool by additive manufacturing includes forming a first layer of eutectic alloy, the forming comprising depositing the eutectic alloy in liquid form and then cooling for form a solid eutectic alloy; forming an additional layer of the eutectic alloy on the first layer, the forming of the additional layer comprising depositing the eutectic alloy in liquid form and then cooling to form the solid eutectic alloy; and repeating forming an additional layer of the eutectic alloy on the first layer, the forming of the additional layer comprising depositing the eutectic alloy in liquid form and then cooling to form the solid eutectic alloy, and repeating one or more times to form a structure comprising a tool body having a tooling surface.
US12226929B2	Component made from a material consisting predominantly of renewable raw materials, having at least one compressed region, and method and tool for producing the compressed region The invention relates to a component made from a material consisting predominantly of renewable raw materials, the component having at least one hole with a longitudinal axis (A) and the material being locally compressed in the region peripherally adjoining the hole. According to the method, at least one pin, which comprises a substantially cylindrical shaft and a tip having a reducing diameter in the direction of the component, penetrates into the material, thus creating a hole in the component, and displaces the wood material radially and/or axially, so that the material in the region surrounding the hole is compressed. The tool used for carrying out the method is designed in the form of at least one pin having a cylindrical or polygonal shaft and a tip reducing in diameter in the direction of the component.
US12226925B2	Spacers for cutting and grinding blades, blade and spacer assemblies, and gang blade assemblies and methods relating to same A spacer, blade core, assembly and methods for blade and blade core assemblies, including gang blade heads, include openings in blade cores for receiving spacers. A spacer and its opening can be the same shape or different shapes, and spacers can be interconnected or disconnected from each other. A spacer can be in contact or engaged with two blades, three blades, or more.
US12226921B2	Lockable tool with sliding scale release A lockable tool with a sliding scale release is formed with a frame and a tool coupled to the frame with a locking mechanism to lock the tool into an extended or retracted configuration. A release mechanism is attached to a scale on the side of the frame. The scale is coupled to the frame. The tool is constructed such that sliding the scale along a longitudinal axis of the frame automatically unlocks the tool from the extended or retracted configurations. The tool can open and/or close automatically. The tool, such as a knife, can swing open or extend out a front opening in the frame.
US12226915B2	Belt conveyor calibration method, robot control method, and robot system A belt conveyor calibration method includes transporting a marker by a belt of a belt conveyor, imaging the marker by a first camera, detecting the marker passing through one section of a plurality of sections formed by division of a first imaging area of the first camera from a captured image of the first camera, moving a second camera by a robot and tracking and imaging the detected marker by the second camera, and calculating and storing a correction value as a difference between a position of the marker estimated from a transportation amount of the belt and a position of the marker detected from an image of the marker tracked and imaged.
US12226914B2	Generation of image for robot operation A robot control system includes circuitry configured to: generate a command to a robot; receive a frame image in which a capture position changes according to a motion of the robot based on the command; extract a partial region from the frame image according to the command; superimpose a delay mark on the partial region to generate an operation image; and display the operation image on a display device, so as to represent a delay of the motion of the robot with respect to the command.
US12226913B2	Methods and systems to remotely operate robotic devices Methods and systems to remotely operate robotic devices are provided. A number of embodiments allow users to remotely operate robotic devices using generalized consumer devices (e.g., cell phones). Additional embodiments provide for a platform to allow communication between consumer devices and the robotic devices. Further embodiments allow for training robotic devices to operate autonomously by training the robotic device with machine learning algorithms using data collected from scalable methods of controlling robotic devices.
US12226910B2	Task execution method and apparatus for robots capable of freely constructing network, and storage medium A task execution method and apparatus for robots capable of freely constructing a network, and a storage medium are provided. The method includes: partitioning, by a server, an entire region of a warehouse to obtain local region(s) corresponding to the partitioned warehouse (S10); receiving capability feature information reported by each robot moving freely within a current warehouse range after the robot comes online (S20); determining, according to the capability feature information reported by the robot, a local center robot, and assigning corresponding to-be-executed task(s) to the local region obtained via the partitioning, such that robot(s) freely constructing a local network execute the to-be-executed task(s) (S30); and after the robot(s) have completed the to-be-executed task(s), receiving task completion information reported by a robot, and releasing the robot to be a free moving robot (S40).
US12226908B2	Control device, control method, and program The present disclosure relates to a control device, a control method, and a program capable of supporting an object with a more appropriate supporting force. The control device includes a supporting force control unit that controls a supporting force for supporting an object on the basis of information regarding a shape of a contact portion in contact with the object and information regarding a shear force of the contact portion. The information regarding the shear force includes, for example, information regarding a shear displacement of the contact portion. The present disclosure can be applied to, for example, a control device, a control method, an electronic device, a robot, a support system, a gripping system, a program, and the like.
US12226907B2	Robotic systems with mass detection, and related systems and methods End effectors for use with a robotic object-gripping system, and related systems and methods, are disclosed herein. In some embodiments, the end effector includes a first mounting structure, a force sensor coupled to the first mounting structure, a second mounting structure coupled to the force sensor, and a gripper assembly coupled to the second mounting structure. The force sensor is beneath the longitudinal plane and is configured to measure forces along a vertical axis. The end effector also includes a first bracket coupled to the first mounting structure and a second bracket coupled to the second mounting structure. The first and second brackets are configured to connect to the connection tubes to isolate the connection tubes, and any forces therein, to a longitudinal direction between the first bracket and the second bracket, thereby reducing the noise on the force sensor from the connection tubes during operation.
US12226906B2	Decentralized rotary actuator A device and a method for actuating a joint of a human, an animal or a robot are disclosed. An elongated, lengthwise flexible and torsionally elastic body is provided for transmitting torque. Based at least in part on torsional deformation information of the body, torque is transmitted via the body. In an embodiment, a flexible drive shaft is provided, whereby the flexible drive shaft comprises said body. Furthermore, use of a flexible drive shaft as compliant element and as torque transmission element in a rotary actuator for actuating a mechanical joint is disclosed. In addition, use of a flexible drive shaft for determining an impedance of a joint of a human or an animal is also disclosed.
US12226903B2	Gait control method, biped robot, and computer-readable storage medium A method for controlling gait of a biped robot includes: collecting a lateral center of mass (CoM) speed and a lateral CoM position of the biped robot when the biped robot walks in place; calculating phase variables of virtual constraints corresponding to the CoM of the biped robot in a first phase and a second phase according to the lateral CoM speed and the lateral CoM position; constructing motion trajectory calculation equations for the biped robot based on the phase variables corresponding to the first phase and the second phase, respectively; and finding inverse solutions for joints of the biped robot using the motion trajectory calculation equations to obtain joint angles corresponding to each of the joints of the biped robot to realize gait control.
US12226900B2	Surgical robot, and control method and control device for robot arm thereof A surgical robot and a control method and device for a robot arm (21) thereof. The surgical robot includes the robot arm (21) and the control device, the control device is configured for acquiring an external force applied on a power mechanism (22); acquiring an input operating command for task degrees of freedom of the power mechanism (22); combining the task degrees of freedom to analyze the external force to obtain target position and/or pose information of the power mechanism (22) at a base coordinate system, according to the target position and/or pose information, controlling a movement of joints of the robot arm to allow the power mechanism (22) to move within corresponding degrees of freedom. The operating command includes a completely matched first operating command, and a partially matched second operating command. The power mechanism (22) of the surgical robot can be precisely freely dragged or constraint control dragged.
US12226898B2	Driving mechanism and robot A driving mechanism according to an aspect includes a first pulley configured to rotate around a first axis, a motor configured to rotate the first pulley around the first axis, a second pulley disposed to be separated from the first pulley and configured to rotate around a second axis parallel to the first axis, a first belt laid around the first and second pulleys and configured to transmit power of the motor from the first pulley to the second pully, a third pulley disposed side by side with the second pulley in a direction along the second axis and configured to rotate around the second axis integrally with the second pulley, a fourth pulley disposed to be separated from the third pulley and configured to rotate around a third axis parallel to the second axis, a second belt laid around the third and fourth pulleys and configured to transmit the power of the motor from the third pulley to the fourth pulley, and a first bearing located between the second and third pulleys and configured to support the second and third pulleys.
US12226894B2	Submersible remote operated vehicle tool interchange A tool interchange for a submersible remote operated vehicle (ROV) arm includes a first interchange body that affixes to an ROV arm. A second interchange body is carried by the first interchange body to rotate on a rotation axis. The second interchange body includes a tool mount actuable between gripping an ROV tool to the second interchange body and releasing the ROV tool from the second interchange body. An inductive power coupling part is provided in the tool mount. The inductive power coupling part is presented outwardly in the tool mount opposite the first interchange body, resides on the rotation axis and is fixed with respect to the first interchange body while the second interchange body rotates. The inductive power coupling part is adapted to inductively communicate power with a corresponding inductor power coupling part of the ROV tool when the ROV tool is docked in the tool mount.
US12226893B2	Gripping assemblies including an adhesive assembly A gripping assembly includes a gripping mechanism for engaging an object and an adhesive assembly coupled to the gripping mechanism. The adhesive assembly includes an adhesive sheet and an engagement mechanism operable between an active state and an inactive state. The engagement mechanism deforms the adhesive sheet to contact the object when operated in the active state.
US12226891B2	Adjustable tool holder for a gun-shaped power tool A tool holder for a gun-shaped power tool includes a base including a first slot and a second slot extending parallel to the first slot, a first support member adjustably securable along the first slot and along a first side of the base, and a second support member adjustably securable along the second slot and along the first side of the base. A tool bit and/or a barrel of the tool may be supported by surfaces of the support members when the tool is stored in the tool holder, so that a grip of the tool is readily accessible by a user. The power tool holder provides a structure for ergonomically positioning and storing a gun-shaped power tool, improving the ease and speed of access of the tool during assembly operations.
US12226887B2	Power tool A power tool includes a power mechanism including a drive shaft; an oscillating mechanism; an airflow element connected to the drive shaft; a heat conducting portion supported on the drive shaft, where the airflow element is disposed on the heat conducting portion. The oscillating mechanism includes a support assembly sleeved on the drive shaft and an oscillating member. Heat generated by the oscillating mechanism is conducted to the heat conducting portion through the drive shaft, the heat conducting portion has a thermal conductivity greater than or equal to 50 W/m·° C., and a ratio of an axial distance L1 of a portion of the heat conducting portion in contact with the drive shaft to a distance L2 of a thermally conductive portion of the drive shaft between the heat conducting portion and the support assembly is greater than or equal to 0.1 and less than or equal to 5.
US12226885B2	Method for determining a remaining service life of a hand-held power tool as well as hand-held power tool A method for determining a remaining service life of a hand-held power tool includes, in an operating mode detection step, detecting an operating mode of the hand-held power tool by an alignment of operating data of the hand-held power tool with a comparative value table stored on the hand-held power tool and/or by a switch position detection function of an operating mode selection switch. In a computing step, the remaining service life of the hand-held power tool is calculated via at least the operating mode and its operating time and output to a user of the hand-held power tool in an outputting step.
US12226882B2	Bearing and shaft installation tooling A tool for mounting a bearing and shaft subassembly in an aircraft engine component, including a rod extending from a first end to a second end and adapted to extend through a hollowed shaft, the rod having a shaft seating portion at the first end adapted to engage a first end of the shaft. A holder is engageable to the second rod end to receive a second end of the shaft. The holder is displaceable towards the shaft seating portion during engagement to the second rod end. At least one sleeve is adapted to wrap about a shaft outer surface, removably securable to the shaft, and having an end defining a bearing facing surface to axially engage the bearing. The holder is displaceable towards that surface to axially load the bearing against the sleeve and maintain the shaft between the holder and the shaft seating portion.
US12226878B2	Abrasive coating including metal matrix and ceramic particles A system may include a powder source; a powder delivery device; an energy delivery device; and a computing device. The computing device may be configured to: control the powder source to deliver metal powder to the powder delivery device; control the powder delivery device to deliver the metal powder to a surface of an abrasive coating; and control the energy delivery device to deliver energy to at least one of the abrasive coating or the metal powder to cause the metal powder to be joined to the abrasive coating.
US12226877B2	Abrasive article The disclosure relates to an abrasive article comprising: a fabric substrate comprising strands forming first void spaces between the strands; a laminate joined to the fabric substrate; a cured resin composition joined to the laminate opposite the fabric substrate; abrasive particles joined to the cured resin composition; and a plurality of second void spaces extending through the laminate coinciding with first void spaces in the fabric substrate. The disclosure also relates to methods of making such abrasive articles.
US12226868B2	Device and method for measuring tools A device for determining a dimension of a tool having a cutting edge includes a first light source configured to emit light parallel to a first axis, an image sensor which is associatable with a second axis extending orthogonally to the image sensor and an analyzing unit. The first axis and the second axis are inclined relative to each other. The device is configured such that the light emitted from the first light source is reflectable by the cutting edge of the tool in such a way that light spots arranged in a line on the image sensor are generatable by the reflected light. The analyzing unit is configured to determine positions of the light spots. The dimension of the tool is determinable based on the positions of the light spots.
US12226867B2	Method for setting more precisely a position and/or orientation of a device head A method for setting more precisely a position and/or an orientation of a device head in a measuring environment by a distance measuring device which has a number of M, M≥1, distance measuring sensors and which is connected to the device head. A control device is communicatively connected to the distance measuring device and an on-board sensor device. The position and/or the orientation of the device head is determined by the on-board sensor device and the position and/or the orientation of the device head determined by the on-board sensor device is set more precisely by the control device.
US12226860B2	Method for manufacturing sintered gear A method for manufacturing a sintered gear comprising the steps of: preparing a cylindrical green compact; gear-cutting the green compact with a hob; and sintering the gear-hobbed green compact, wherein the hob is such that a ratio of a number of cutting edges thereof per round to a number of starts thereof exceeds 8.
US12226856B2	Solder material, method for producing a solder material of this type and use of a solder material of this type in order to connect a metal layer to a ceramic layer A solder material (30) for bonding a metal layer (20) to a ceramic layer (10), in particular for forming a metal-ceramic substrate as a carrier for electrical components, comprising: a base material and an active metal, wherein the solder material (30) is a foil comprising the base material in a first layer (31) and the active metal in a second layer (32), and wherein the foil has a total thickness (GD) which is less than 50 μm, preferably less than 25 μm and particularly preferably less than 15 μm.
US12226855B2	Iron-aluminum-based intermetallic compound filter element and preparation method thereof The present invention discloses a Fe—Al intermetallic compound filter element and a preparation method thereof, which relates to the field of powder metallurgy and filtration technology. In view of the drawback in the prior art that using a fiber felt as a filtration layer reduces stability and reliability of a filter, the present invention provides an Fe—Al intermetallic compound filter element, which comprises: at least two filter-element parts, and a rebar connecting the at least two filter-element parts transversely by means of welding, wherein, the filter-element parts each comprises at least two segments of Fe—Al intermetallic compound filter-element powder tube and a connector connecting the at least two segments of Fe—Al intermetallic compound filter-element powder tube end-to-end by means of welding; and wherein, the at least two segments of Fe—Al intermetallic compound filter-element powder tube each comprises a substrate framework and a surface filtration membrane.
US12226853B2	Surface processing method and structure Provided is a surface treatment method of a metallic material having a protective layer formed thereon. A surface of the protective layer is scanned while irradiating the surface and the surface is scanned while moving an irradiation spot along the surface, in a state in which a side layer of the protective layer along the metallic material remains covering the metallic material, and a side layer of the protective layer opposite to the metallic material side is removed by irradiation with the laser beam.
US12226848B2	Method for joining metal materials and controlling bonding quality thereof The method comprises applying a spot load to a joint part between a first metal material and a second metal material in a state where sites to form the joint part are superposed on each other. When a total thickness of the first metal material and the second metal material at the joint part before bonding is defined as T0 mm, the total thickness thereof after bonding is defined as T1 mm, and T0/T1=R is defined as a reduction ratio, the reduction ratio R is 1.4 or more.
US12226847B2	Apparatus for replacing welding tip of welder and apparatus for supplying same An apparatus for supplying a welding tip of a welder and an apparatus for replacing the same include a fixed bracket secured to a support. The apparatus includes an actuator coupled to the fixed bracket and a first moving member moved by the actuator. A second moving member is coupled to the first moving member and hingedly coupled to the fixed bracket. A third moving member is hingedly coupled to the second moving member. A first welding tip removal member is coupled to the third moving member to separate a welding tip coupled to a shank. A fourth moving member is disposed opposite to the first moving member. A fifth moving member is coupled to the fourth moving member and hingedly coupled to the fixed bracket. A sixth moving member is coupled to the fifth moving member. A second welding tip removal member is coupled to the sixth moving member.
US12226845B2	Apparatus and method for cleaning oxide film An apparatus and method for cleaning an oxide film using a direct current reverse polarity are provided. The apparatus for cleaning an oxide film formed on a workpiece may include a power supply configured to apply direct current power and to include a positive electrode terminal and a negative electrode terminal, the workpiece configured to be electrically connected to the negative electrode terminal to act as a negative electrode to which a current is applied, and a torch having a positive electrode, which is spaced apart from the oxide film by a predetermined distance and is electrically connected to the positive electrode terminal, the torch being installed to be movable relative to the workpiece. The oxide film formed on the workpiece may be removed by applying a reverse polarity direct current between the workpiece, serving as the negative electrode, and the positive electrode to generate an arc.
US12226840B2	Rotary cutting tool cutting insert and rotary cutting tool A straight line along the second line segment and a straight line along the fourth line segment form an acute angle. The straight line along the second line segment and the straight line along the third line segment form an obtuse angle. The straight line along the first line segment and the straight line along the fourth line segment form an obtuse angle. Each of the third curved portion and the fourth curved portion is larger in radius of curvature than the first curved portion and larger in radius of curvature than the second curved portion. In a direction perpendicular to the bottom surface, a distance between the top surface and the bottom surface is equal to a distance between the cutting edge and the bottom surface, or is shorter than the distance between the cutting edge and the bottom surface.
US12226833B2	Device for atomizing a melt stream by means of a gas A device for atomizing a metallic, intermetallic or ceramic melt stream by means of a gas to form a spherical powder, comprising a melt chamber, a powder chamber, an induction coil in the melt chamber, a melt material, preferably melt rod in the induction coil and an atomizer nozzle interconnecting the melt and powder chambers and being arranged in a nozzle plate, for the melt stream melted off from the melt material by the induction coil, wherein the atomizer nozzle has an exclusively convergent nozzle profile having nozzle flanks which have a circular-arc-shaped cross-section, and therefore both the atomizing gas and the melt stream and the droplets generated therefrom reach a velocity which is at most equal to, preferably below the acoustic velocity of the atomizing gas.
US12226826B2	High-strength and high-plasticity titanium matrix composite and preparation method thereof The present invention provides a high-strength and high-plasticity titanium matrix composite and a preparation method thereof. The preparation method includes: preparing high-oxygen hydride-dehydride titanium powder using a high-temperature rotary ball grinding treatment process, in which the prepared hydride-dehydride titanium powder has a particle size of 10-40 μm, and has an oxygen content of 0.8-1.5 wt. %; preparing high-purity ultra-fine oxygen adsorbent powder using a wet grinding method of high-energy vibration ball grinding treatment process; in which a purity of the oxygen adsorbent powder is ≥99.9%, and a particle size of the oxygen adsorbent powder is ≤8 μm; mixing the high-oxygen hydride-dehydride titanium powder with the oxygen adsorbent powder in a protective atmosphere, and then press-forming the powder obtained after mixing to obtain a raw material blank; and performing atmosphere protective sintering treatment on the raw material blank to obtain a titanium matrix composite. The method prepares a titanium matrix composite reinforced by in-situ self-generating multi-scale Ca—Ti—O, TiC, TiB particles. The microstructure and grains are effectively refined, and the strength and plasticity of the material are significantly improved.
US12226823B2	Alloy composition, method and apparatus therefor Aspects of the disclosure are directed to forming a three-dimensional (3D) structure by depositing an alloy composition on a target, and solidifying portions of the alloy composition to form the 3D structure. The solidifying includes producing a martensitic structure by destabilizing a ferrite phase of the alloy composition while solidifying the alloy composition.
US12226822B2	Additive manufacturing process of 3D electronic substrate A method of forming electronic substrates and assemblies is provided. The method includes forming a first layer, including co-depositing a first material and a second material, where the first material and the second material are co-deposited as powders, binders, slurries, inks, or combinations thereof, and at least partially sintering or curing the first layer of co-deposited materials. Further, the method includes forming a second layer, including co-depositing the first material and the second material, and at least partially sintering or curing the second layer of co-deposited materials. Additionally, the method includes retrieving a solid electronic substrate wherein the sintered or cured first material of the first layer forms the solid electronic substrate and the sintered or cured second material of the first layer forms a feature in or on the solid electronic substrate.
US12226819B2	4D printing method for in-situ regulation of functional properties of nickel-titanium alloy and use thereof The present invention belongs to the field of additive manufacturing technology, and discloses a 4D printing method capable of in-situ regulating functional properties of nickel-titanium (NiTi) alloys and the application thereof. The method comprises the following steps: subjecting NiTi alloy bars to atomization milling to obtain NiTi alloy powder with a particle size of 15-53 μm, placing the NiTi alloy powder in a discharge plasma assisted ball mill for discharge treatment to promote the activation of powder activity, then adding nano-sized Ni powder with a particle size of 100-800 nm to obtain mixed powder, then continuing the discharge treatment to realize the metallurgical bonding between the NiTi alloy powder and the nano-sized Ni powder to obtain the modified powder, and finally using the additive manufacturing technology to prepare and form the modified powder into a functionalized NiTi alloy. The present invention achieves the metallurgical bonding between the nano-sized Ni powder and the large-sized spherical NiTi alloy powder by adding the nano-sized Ni powder in the process of discharge treatment, which is conducive to preparing a bulk alloy with uniform composition, structure and properties and the parts made therewith.
US12226814B2	Method for controlling a cooling device in a rolling train A method for controlling a cooling device which is set up to control temperature of a rolling stock such as a metal strip, which runs through a cooling device along a conveying direction of a rolling train. The cooling device is arranged upstream of the rolling train. The method includes determining total enthalpy of a system formed by the rolling stock; determining a measure for the formation of scale, which includes a scale factor that depends on chemical composition and surface temperature of the rolling stock, and a heat transfer coefficient of the scale; calculating a temperature distribution and/or average temperature in the rolling stock based on a temperature calculation model, in which the determined total enthalpy and the measure for the formation of scale are included; and setting a cooling capacity of the cooling device taking into account the calculated temperature distribution and/or average temperature in the rolling stock.
US12226813B2	Tapered structure construction Feeding stock used to form a tapered structure into a curving device such that each point on the stock undergoes rotational motion about a peak location of the tapered structure; and the stock meets a predecessor portion of stock along one or more adjacent edges.
US12226805B2	Substrate cleaning brush In a holder attached state in which a holder upper part 11 is attached to a brush rotation shaft 2, the lower surface of the holder upper part 11 and the inner peripheral surface of a holder lower part 18 define a brush accommodating space 23, and the inner peripheral edge of a holder bottom plate part 19 defines a circular holder opening 24 having a smaller diameter than the inner diameter of the holder lower part 18. A held part 31 of a brush body 30 is in a circular column shape incapable of penetrating through the holder opening 24, and is accommodated and held in the brush accommodating space 23. A cleaning part 32 of the brush body 30 is in a circular column shape smaller in diameter than the held part 31 and capable of penetrating through the holder opening 24, and penetrates through the holder opening 24 and projects downward. A top-to-bottom length L2 of the holder opening 24 of the brush holder 10 is longer than or equal to ¼ of a protruding length L1 of the cleaning part 32 of the brush body 30 from the held part 31 thereof and shorter than the protruding length L1 of the cleaning part 32.
US12226804B2	Support for transporting containers in a microwave inspection device and a device and method of inspection of containers using the support A support for transporting containers in a microwave inspection device, including a supporting body which can be moved along a feed path and at least two receiving seats connected to the top of the supporting body to be moved along said feed path, wherein said supporting body has two or more supporting portions (S1, S2) which are at least partly separated from each other by one or more openings and each carrying at least one respective receiving seat, said supporting portions (S1, S2) being connected or integral with each other in a lower region of the supporting body.
US12226803B2	Device for separating and recovering flat-plate catalyst powder and method for determining wear ratio A device for separating and recovering flat-plate catalyst powder and a method for determining a wear ratio are provided. The device includes a powder separation unit and a powder recovery unit, a powder accumulation bin is respectively connected with a shell and a catalyst powder outlet, a cyclone outlet is configured on an inner side of a recovery shell, and a primary filter and a secondary filter are configured on an inner side wall of the recovery shell.
US12226800B2	Acoustic transducer An acoustic transducer (30), comprising: a support structure (36); an active assembly comprising a base plate (32) supported by the support structure (36) and a piezoelectric body (34) supported by the base plate (32); and a passive vibrator (38) supported by the support structure (36) and coupled via the support structure (36) to the active assembly (32, 34) so that vibration of the active assembly (32, 34) drives the passive vibrator (38). The active assembly (32, 34) and the passive vibrator (38) have the same resonant frequency.
US12226798B2	Power console for a surgical tool that includes a transformer with an integrated current source for producing a matched current to offset the parasitic current Control console for a powered surgical tool that includes a transformer with a secondary winding across which the tool drive signal is present. Also internal to the transformer is a matched current source that consists of a leakage control winding and a capacitor. The current sourced by the matched current at least partially cancels out leakage current that may be present.
US12226794B2	Spreading unit with adjustable shaper The disclosure relates to a spreading unit having a shaper for spreading viscous material, in particular sealing material, on a component, wherein the shaper has a first shaping contour for shaping the viscous material in the process of the spreading, wherein at least a second shaping contour of the shaper for shaping the viscous material can be brought by means of an actuator, in a direction of spreading, into superimposition with the first shaping contour, so that a shape of the shaper is adjustable during an application process.
US12226792B2	Nozzle arrangement for applying fluids, and method for producing a main body of such a nozzle arrangement A nozzle arrangement for applying fluids to a substrate has a main body which is able to be connected to a mounting region of a distributor and which has an end-side side surface. At least one first outlet nozzle for the fluid to be applied to the substrate is provided in or on the end-side side surface of the main body. A first fluid channel system is formed in the main body, via which the at least one first outlet nozzle is connected in terms of flow to a first fluid connector, which is provided in the main body of the nozzle arrangement. The nozzle arrangement is a monolithic component produced by an additive production method.
US12226791B2	Dispenser with air mixing A nozzle assembly includes a mixing channel and an aerator. The mixing channel has upstream and downstream ends defining a flow direction through the mixing channel and includes a housing wall and a mixer. The housing wall defines a flow passage and includes an inlet portion and a tip orifice. The inlet portion disposed at the upstream end and configured to receive a first material and a second material. The tip orifice is disposed at the downstream end and is configured to emit a plural component material from the mixing channel. The mixer is disposed within the mixing channel and is configured to mix the first material and the second material into the plural component material. The aerator is configured to flow nucleation air to a location downstream of an upstream end of the mixer and into a flow of the plural component material.
US12226789B2	Nozzle hanger A nozzle hanger 1 for hanging a filling nozzle 11, of which one end has a filling pipe 11a for filling a hydrogen gas and the other end has a grip section 11b, is provided with: an upper part 2 that holds the filling pipe of the filling nozzle; a lower part 3 that faces the upper part and holds the grip section of the filling nozzle; and an intermediate part 4 that connects the upper part and the lower part, wherein the lower part is provided with a fixed lock section (a recessed section 6, a stepped section 7) that locks the grip section of the filling nozzle in a fixed state, and the upper part is provided with a movable lock section 5 that contacts the filling pipe of the filling nozzle and locks the filling pipe in a movable state.
US12226788B2	Dispenser A dispenser is disclosed that includes a pump having a pump chamber that receives a fluid, a pulsation dampener, and a discharge conduit. The pulsation dampener has a dampener housing with an interior volume and a dampener housing opening. A spring biased movable piston is located in the interior volume of the pulsation dampener and defines a variable volume headspace between the piston and the dampener housing opening. The discharge conduit provides fluid communication between each of an outlet of the pump chamber, the dampener housing opening, and a nozzle such that, when the pump is activated, at least a portion of fluid from the outlet of the pump chamber flows within the discharge conduit to the dampener housing opening. The dispenser is configured to, when the pump is activated, emit a substantially constant stream of fluid from the nozzle for at least one second.
US12226787B2	Pump dispenser and containers A pump dispenser comprising a container having a neck (6) to which the pump is attached. A pump body (1) has an outward flange (91) through which it is supported on the edge of the container neck (6). A body/neck rotation stop mechanism (64,7) is provided by an interlock engagement between the pump body and the container neck, and has widely-spaced interlock projections (64) on the container neck (6), e.g. one or two projections, each having a circumferentially-directed abutment face (642). A series of spaced interlock teeth (71) projects down from the outward flange (91) of the pump body and these have respective abutment faces (711) to engage the neck projections and limit relative rotation of the pump body and neck. This can assure reliable action of a plunger-locking mechanism of the dispenser.
US12226785B2	Vacuum chamber structure of ultra-high gravity geotechnical centrifuge device A vacuum chamber structure of an ultra-high gravity geotechnical centrifuge device, comprising: a cylindrical shell, a convex head, a bottom head, a lower bearing sealing cover, and a vacuum pressure-bearing chamber formed by sealing a top cylindrical cylinder and an upper sealing plate with sealing rings; wherein a high-speed rotor system is enclosed in the vacuum pressure-bearing chamber, and a cylindrical cooling device is installed between an internal side of the cylindrical shell and the high-speed rotor system. An annular cooling device is provided directly above the hanging baskets on both sides of the centrifuge arm. A vibration isolation expansion joint is arranged at the intersection of the high-speed rotor system and the cylindrical cylinder, which isolates the vibration of the main engine from the vacuum chamber and greatly reduces the vibration.
US12226784B2	Magnetic bead purification system The present invention provides a magnetic bead purification system, including: a housing; a liquid path treatment system provided inside the housing, the liquid path treatment system being connectable to a reagent barrel and a waste liquid barrel; a sample addition needle group connected to the liquid path treatment system, the sample addition needle group being movable within the housing and connected to the liquid path treatment system, so as to receive a reagent from the liquid path treatment system or to discharge a waste liquid to the liquid path treatment system; a purification magnetic separation system, including a magnetic element, the purification magnetic separation system being controllable to apply a lateral magnetic force to a purification treatment position inside the housing or stop the application of the magnetic force by the magnetic element; and a purification station system movable between a purification treatment position inside the housing and a loading position outside the housing, the purification station system being adapted to load a container. The magnetic bead purification system of the present invention can easily achieve large capacity sample treatment.
US12226781B2	Flywheel for a wood chipper and process for making thereof A wood chipper, a flywheel therefor, and a process of making the flywheel. A plurality of plates are laser cut to each have a thickness up to about ⅜ inch, including laser cutting a plurality of apertures in each of the plates and laser cutting a central opening in each of the plates for receiving a shaft for effecting rotation of the flywheel. The plurality of plates are laminated together by inserting fasteners in corresponding ones of the apertures in the plates. At least one knife is attached to the laminated plates for cutting wood material to form chips of the wood material as the flywheel is rotated.
US12226776B2	Preparing substances in a medical diagnostic system Operations performed according to the example techniques described herein include controlling a probe to pierce a stopper of a container containing a substance, where the stopper provides an air-tight seal for the container, and where the air-tight seal supports an internal pressure in the container. The operations also include detecting the internal pressure based on information from a pressure sensor; determining that the internal pressure is not at a target pressure and, based on determining that the internal pressure is not at the target pressure, controlling the probe either to aspirate air from the container or to dispense air into the container in order to move the internal pressure toward the target pressure.
US12226774B2	Microfluidic device and direct measurement of reaction rate Embodiments disclosed herein may relate to a testing apparatus. The testing apparatus may include a sealed, chemically-resistant testing apparatus body defining a testing void; a first fluid port and a second fluid port; and a first geomaterial and a second geomaterial. The first and second geomaterials may be positioned between the first fluid port and the second fluid port and relative to one another such that a flow channel may be provided between the first and second geomaterials. The first and second geomaterials may be coupled to a testing void interior surface so as to restrict flow to the flow channel between an upflow region and a downflow region of the testing void. The first and second geomaterials may be comprised of a natural formation material.
US12226772B2	Biochip and manufacturing method thereof A biochip and a method for manufacturing the same are provided. The biochip includes: a guide layer; a channel layer on the guide layer, wherein the channel layer has therein a plurality of first channels extending in a first direction; a plurality of second channels extending in a second direction, wherein each of the plurality of second channels is in communication with the plurality of first channels, the plurality of second channels are in a layer where the channel layer is located, or in a layer where the channel layer and the guide layer are located; an encapsulation cover plate on a side of the channel layer distal to the guide layer; and a driving unit configured to drive biomolecules to move.
US12226769B2	Sample manipulation and assay with rapid temperature change The disclosure relates to a device and method of using the device for performing biological and chemical assays that require an easy sample manipulation and/or a rapid change or a rapid thermal cycling of a sample temperature (e.g., Polymerase Chain Reaction (PCR) for amplifying nucleic acids). The device includes a first plate, a second plate, a plurality of spacers, and at least one clamp. The method includes obtaining the device, depositing a sample onto a sample contact area of at least one of the first and second plates of the device in an open configuration, closing the two plates into a closed configuration and placing the clamp in the active mode, and rapidly changing the temperature of the sample portion encircled by rings.
US12226766B2	Removing and reinserting protein nanopores in a membrane using osmotic imbalance Techniques for replacing nanopores within a nanopore based sequencing chip are provided. A first electrolyte solution is added to the external reservoir of the sequencing chip, introducing an osmotic imbalance between the reservoir and the well chamber located on the opposite side of a lipid bilayer membrane. The osmotic imbalance causes the membrane to change shape, and a nanopore within the membrane to be ejected. A second electrolyte solution is then added to the external reservoir to provide replacement nanopores and to restore the membrane shape. The replacement nanopores can be inserted into the membrane, effectively replacing the initial pore without causing the destruction of the membrane.
US12226765B2	Microwave assisted fluidized bed reactor System and methods for plasma treatment of a fluidized bed of particles are disclosed. The systems include an energy coupling zone configured to generate a plasma from microwave radiation and an interface element configured to propagate the plasma from the energy coupling zone to a reaction zone. The reaction zone is configured to receive the plasma, receive a plurality of reactant particles in a fluidization plane direction from a fluidization assembly positioned below the reaction zone, and form a product in presence of the plasma. The fluidization plane is substantially perpendicular to the propagated plasma.
US12226764B2	Annular catalyst carrier container for use in a tubular reactor A catalyst carrier for insertion in a reactor tube of a tubular reactor, said catalyst carrier comprising: a container for holding catalyst in use, said container having a bottom surface closing the container, and a top surface; a carrier outer wall extending from the bottom surface to the top surface; a seal extending from the container by a distance which extends beyond the carrier outer wall; said carrier outer wall having apertures located below the seal.
US12226762B2	Antioxidant protection for ion exchange resins Methods of stabilizing virgin ion exchange resin material are provided. The methods include cleansing the virgin ion exchange resin material with a preparation comprising a non-ionic detergent. The methods include cleansing the virgin ion exchange resin material with a preparation comprising an alcohol solvent. The methods include rinsing virgin ion exchange resin material with deoxygenated water, the methods include introducing the cleansed/rinsed virgin ion exchange resin material into a gas impermeable vessel and hermetically sealing the vessel. The methods include introducing an oxygen scavenging material into the gas impermeable vessel, and hermetically sealing the vessel. A method of facilitating water treatment in a site in need thereof by providing a cleansed virgin ion exchange resin material in deoxygenated water is also disclosed.
US12226759B2	Perylene imide and composite photocatalytic material thereof, preparation method therefor and application thereof in removing organic pollutants from water Melamine is calcined to obtain melem; melem, perylene tetracarboxylic dianhydride and a solvent are mixed to obtain a mixture, and the mixture is subjected to a solvothermal reaction in an inert atmosphere to obtain perylene imide; and the perylene imide is dispersed in an aqueous solution containing a bismuth source and a tungsten source, and is subjected to a hydrothermal reaction to obtain a perylene imide/bismuth tungstate composite photocatalytic material. By means of constructing an organic-inorganic composite photocatalytic material, the introduction of the organic photocatalytic material that responds to visible light may enable the composite material to have a wider spectral response range; and the introduction of an inorganic semiconductor catalyst enables the composite material to produce more oxidizing active free radicals, thereby enhancing the photocatalytic degradation performance of the composite material on organic pollutants. The constructed organic-inorganic composite photocatalytic material has an excellent catalytic performance.
US12226758B2	Raney copper catalyst as well as preparation method and use thereof A Raney copper catalyst, a preparation method and use thereof are provided. The Raney copper catalyst includes aluminum, copper and a metal promoter, wherein the metal promoter comprises a combination of one or more of Ni, Fe, Mo, Co, Ag, Pd, Pt, Au and other elements. The preparation method includes performing high-temperature melting on a mixture containing a copper/aluminum alloy and the metal promoter to obtain a mixed metal cured compound, then smashing the mixed metal cured compound to obtain a catalyst precursor, and subsequently activating to obtain the Raney copper catalyst. The Raney copper catalyst exhibits a capability on hydrogenation reaction based on synergistic effects between metal copper and different promoter metals. Compared with the Raney copper catalyst without metal promoters, when used for preparing 1,3-propanediol through hydrogenation of 3-hydroxypropionaldehyde aqueous solution, the Raney copper catalyst is higher in activity and better in stability.
US12226756B2	Catalyst system and method for its preparation The present disclosure relates to a catalyst system and a method for its preparation. The catalyst system of the present disclosure comprises a support, a promoter component impregnated in the support, and an active metal component comprising nickel, cobalt, and molybdenum impregnated in the support. In the active metal component the molar mass of molybdenum is greater than the combined molar mass of cobalt and nickel. The catalyst system of the present disclosure is used for upgrading crude bio oil.
US12226748B2	Stirrer, apparatus of manufacturing quantum dot including the same, and method of manufacturing quantum dot using the quantum dot manufacturing apparatus A stirrer includes a magnetic bar and a microwave absorbing layer around the magnetic bar. The stirrer absorbs a microwave and converts the microwave to thermal energy to heat the mixed solution reactant.
US12226746B2	Reversing bias in polymer synthesis electrode array Polymers synthesized by solid-phase synthesis are selectively released from a solid support by reversing the bias of spatially addressable electrodes. Change in the current and voltage direction at one or more of the spatially addressable electrodes changes the ionic environment which triggers cleavage of linkers that leads to release of the attached polymers. The spatially addressable electrodes may be implemented as CMOS inverters embedded in an integrated circuit (IC). The IC may contain an array of many thousands of spatially addressable electrodes. Control circuity may independently reverse the bias on any of the individual electrodes in the array. This provides fine-grained control of which polymers are released from the solid support. Examples of polymers that may be synthesized on this type of array include oligonucleotides and peptides.
US12226743B2	Methods for mixing a fluid with foldable impellers A method of mixing a fluid includes at least partially unfolding a collapsible bag bounding a compartment, the collapsible bag containing in the compartment at least a portion of an elongated drive line or drive shaft and an impeller secured to the drive line or drive shaft, the impeller including a plurality of impeller blades that are pivotable relative to the drive line or drive shaft, at least one of the plurality of impeller blades being in a collapsed position. A fluid is delivered into the compartment of the collapsible bag. The drive line or drive shaft is then rotated so as to rotate the impeller within the compartment and mix the fluid therein, the at least one of the plurality of impeller blades pivoting from the collapsed position to an expanded position as the impeller is rotated within the compartment.
US12226733B2	Systems and methods for concentrating gas Systems and methods are provided that obtain the same or better level of performance by using lower operating flow rates, pressures and/or optimized flow distributions within the system. This extends the life of system components and lower energy consumption. In one embodiment, gas separation (or sieve) beds that are used to separate gaseous components are provided that have lower flow and pressure requirements compared to conventional beds. The sieve beds include, for example, a diffuser having low solid area in cross-section and maximum open area for flow while providing adequate mechanical properties to contain sieve material and support filter media. In another embodiment, systems and methods are provided having an indicator when a component has been serviced or repaired. This provides an indication whether the component has been tampered with in any manner. This allows the manufacturer to determine if the component was serviced, repaired, or tampered with outside the manufacturer's domain.
US12226729B2	Systems and methods for removing carbon dioxide from a fluid Some embodiments are directed to a system for extracting carbon dioxide from a fluid. The system can include a fluid source and a reactor. The reactor can include one or more chambers, and each chamber can include one or more monoliths for adsorbing carbon dioxide from the fluid. The chambers can be alternatively unsealed for a contacting mode and sealed for a regeneration mode. A power source can provide an electric current to the monoliths to release carbon dioxide adsorbed by the monoliths. Each chamber can include an array of monoliths. Each monolith can include a sorbent that adsorbs carbon dioxide from fluid. The system can include modular components such that the number of reactors can be increased or decreased.
US12226721B2	Filter buoy assembly A water filter buoy assembly includes a float, a frame for holding a filter, and at least one arm connecting the float to the frame.
US12226717B2	Supporting device and method of manufacturing A supporting device for a filter device including a flat-woven material manufactured of warp devices and weft devices, which form a woven surface, wherein the flat-woven material shows, in two opposite end portions, two free ends of warp devices or weft devices protruding from the woven surface. The flat-woven material is shaped to form a predetermined three-dimensional shape with a free cross-section, and the free ends overlap and are interconnected. The present method provides for shaping the flat-woven material around a molding part until the free ends of the two end portions overlap. The ends are interconnected. A filtering device accordingly includes a supporting device and a filter device.
US12226712B2	Sump pump system and methods for removing synthetic ester-based fluids from an emulsion A polishing filter apparatus employed within a sump pump system for removing mineral oils, natural ester, and synthetic ester-based fluids from an emulsion is provided. The polishing filter apparatus is connected to a sump pump barrier via a polishing filter inlet conduit. Further conduit structures are disposed within the polishing filter apparatus, which lead into a polishing filter cartridge. The polishing filter removes excess synthetic ester-based fluids from a water/oil emulsion fluid flowing therethrough and releases a resultant filtered fluid. The polishing filter cartridge contains a filtration media with a hydrophilic composition for the capture of synthetic ester-based fluid having a surface tension dissimilar to water, and the hydrophilic composition of the media has a surface energy greater than or equal to 35 dynes per centimeter.
US12226711B2	Smart dehysalter system A system includes a vessel containing a crude oil inlet for introducing crude oil into the vessel; a fixed super-hydrophobic mesh subsystem comprising a fixed super-hydrophobic mesh; an inductor cup set system comprising at plurality of inductor cups, each of the plurality of inductor cups comprising a primary coil and a secondary coil, the inductor cups to determine an amount of water in the crude oil based on a comparison of the induced voltage between the primary coil and the secondary coil; a movable super-hydrophobic mesh subsystem comprising a super-hydrophobic mesh coupled to at least one stepper motor, the stepper motor to rotate the mesh by a predefined angle based on the comparison of the induced voltage determined by the inductor cups; and a metal grid subsystem comprising a metal grid electrically coupled to a transformer residing outside of the vessel, the metal grid to electrostatically dehydrate the crude oil.
US12226708B2	Jigsaw puzzle table A jigsaw puzzle table includes: a puzzle board; a board bracket, wherein the puzzle board is mounted on a mounting end of the board bracket; a lower support, wherein the board bracket is mounted between the puzzle board and the lower support, the board bracket and the lower support are configured to support the puzzle board, the board bracket and the lower support are movably connected to each other; and a positioning fastener, connected to at least one of the board bracket and the lower support. The positioning fastener is configured to secure the board bracket and the lower support to fix a height of the puzzle board. The positioning fastener is further configured to release the security between the board bracket and the lower support to enable the board bracket and the lower support to be at least partially movable to adjust the supported height.
US12226706B2	Apparatus and method for playing modified chess game with players of different proficiency levels Embodiments of the present disclosure disclose an apparatus and method for playing modified chess game. The apparatus includes an expandable game to operate between a conventional mode and a powered mode. The apparatus further includes two sets of playing pieces, visually distinguished from each other are configured to operate in the conventional mode. The at least two bishops, the at least two knights, the at least two rooks, and the at least eight pawns of at least one set of the two sets of playing pieces are provided with a toggle switch. The toggle switch is adapted to form corresponding powered playing pieces during the modified chess game. The powered playing pieces are operated based on a set of powered rules. The apparatus further includes a power zone provided on a portion of the expandable game board to regulate movement of the powered playing pieces in the powered mode.
US12226705B2	Method for controlling game apparatus, game system, and recording medium A program recorded on a computer-readable recording medium causes a processor of a game apparatus to function as a game controller that executes a video game and generates video information indicative of a video of the video game; and an acquirer that acquires message information that is output from a terminal apparatus configured to display a distributed video that is based on the video information, the message information including a message related to at least one of the distributed video or the video game. The game controller incorporates the message included in the message information into the video of the video game, based on progress status information indicative of a progress status of the video game.
US12226704B2	Virtual operation object control method and apparatus, storage medium, and electronic device A method for virtual object control in a game application includes detecting a first virtual resource transfer operation when a distance between a first virtual object and a first virtual obstacle is less than or equal to a first predetermined distance threshold. The first virtual object is located in a first virtual region, the first virtual obstacle is in a first locked state that prevents the first virtual object from entering a second virtual region. Then, the method includes switching the first virtual obstacle from the first locked state to a first unlocked state that allows the first virtual object to enter the second virtual region based on a reduction of virtual resources from the first virtual object. Then, the method includes controlling the first virtual object to enter the second virtual region when a first control operation is detected. Apparatus and non-transitory computer-readable storage medium counterpart embodiments are contemplated.
US12226703B2	Client device for validating play of game applications via game NFTS and methods for use therewith An NFT system operates by receiving an application launch request for a game application having a game non-fungible token (NFT) associated therewith; generating, via the game application and in response to the application launch request, launch metadata; sending the launch metadata to an NFT wallet, the NFT wallet containing a private key associated with the game NFT; receiving, from the NFT wallet, a launch response that is generated based on the private key; generating, via the game application and based on the launch response, an ownership check; sending the ownership check to a blockchain system that stores the game NFT; receiving, from the blockchain system, an ownership validation response; and enabling, via the game application, play of the game when the ownership validation response indicates ownership of the game NFT is verified.
US12226701B2	Game analytics using natural language processing A processor executes program code that represents a portion of a video game and adds a sequence of text strings that represent game events to a text log during execution of the program code. The processor (or another processor that has access to the text log) performs a natural language processing (NLP) analysis of the text log to determine one or more characteristics of the portion of the video game. In some cases, the NLP analysis includes a sentiment analysis that attempts to determine characteristics of a player's experience while playing the video game, summarization technology that creates a human-readable summary of an aspect of the game or a portion of the video game, a semantic NLP ML algorithm in the semantic similarity modality to answer questions regarding the player's experience during the video game, or grouping players in a multiplayer game based on in-game behavior.
US12226700B2	Video game for enabling reversal of potentially-reversible real-world health conditions of players A system and method may include generating, by a computing system, a list of selectable challenge factors for a player to select one or more challenge factors when playing a video game. The player may be provided with the ability to set a plan for each of the challenge factors. A protocol inclusive of the planned challenge factors may be established to be achieved over a time period. A player interface may be displayed for the player of the video game, where the player interface may show the protocol inclusive of at least a portion of the planned challenge factor(s) along with corresponding input elements associated with each planned challenge factor for the player to account for the planned challenge factors by submitting whether or not the player achieved each of the respective planned challenge factors. Achieving the planned challenge factor(s) causes a health condition to be reversed.
US12226696B2	Gaming with earpiece 3D audio A method of providing an enhanced gaming experience includes steps of sensing environmental audio with at least one microphone of an earpiece, combining a game sound with the environmental audio to provide a composite audio signal, and transducing the composite audio signal at the earpiece. The game sound may be positioned within a three-dimensional audio environment. The composite audio signal may be transduced to provide a three-dimensional audio experience.
US12226693B2	Object prompting method, apparatus, and device in virtual scene, and storage medium An object prompting method includes: displaying a virtual scene picture and superimposing and displaying compass information on the virtual scene picture, a first azimuth scale in the compass information indicates an orientation of the first virtual object in the virtual scene; and displaying an object prompt identifier in response to a sound source object producing a sound in the virtual scene, the object prompt identifier indicates a presence of a sound source producing a sound in a direction corresponding to a second azimuth scale in the compass information. The foregoing method overcomes issues associated with a display of an object prompt identifier being limited by a display region area, a display effect of an object prompt identifier of a sound source object is improved, such that an interaction efficiency of a virtual scene interface is also improved.
US12226690B2	Resolution-based scaling of real-time interactive graphics An electronic game server receives a request from a client device to establish a real-time interactive gaming session, determines a device capability of an output device associated with the client device, determines a connection capability of the network connection, determines one or more target quality parameters for the real-time interactive gaming session based on the device capability and the connection capability, selects a first virtual machine of the plurality of virtual machines based on the one or more target quality parameters, establishes the real-time interactive gaming session with the client device, and provides to the real-time interactive gaming session, in accordance with the resource profile of the first virtual machine, resources for processing inputs from the client device and generating gameplay outputs in accordance with the processed inputs within the real-time interactive gaming session.
US12226689B2	Method and apparatus for game streaming A method and apparatus for game streaming are provided. The streaming method according to one embodiment includes generating a first image including a part of a plurality of screen elements constituting a game play image and a second image including a remaining part of the plurality of screen elements, determining an image quality of each of the first image and the second image such that the image quality of the first image is higher than or equal to the image quality of the second image, encoding each of the first image and the second image based on the determined image quality of each of the first image and the second image, and streaming the encoded first image and the encoded second image to a client device.
US12226687B2	Game program, game method, and terminal device A behavior of a character arranged in a virtual space is produced. The behavior of the character is produced in a first part, based on data including motion data obtained by a capture of a motion of a performer who plays the character, and the behavior of the character is produced in a second part, based on data depending on an input from the performer, the input obtained in a mode different from the capture. The character viewed from a predetermined point of view in the virtual space is capable of being displayed on a predetermined display unit.
US12226680B2	Interactive sports training system and method An interactive sports training system, including a basketball hoop on a basketball platform, a metal structure connected to the basketball hoop, a main post connected to the basketball hoop and the metal structure, a plurality of back structure bars connected to the main post, a plurality of foldable ground construction bars connected to the main post, a plurality of side nets positioned to form a triangular structure with the main posts and the plurality of foldable ground construction bars connected to the main post, a football post located in a football platform, and a plurality of metal bars. The plurality of metal bars provide connection of the plurality of side nets with a telescopic net carrier structure.
US12226679B2	Golf club having a damping element for ball speed control A golf club head including a striking face, a periphery portion surrounding and extending rearwards from the striking face, a damping element including a front surface and a rear surface, the rear surface of the damping element opposite the front surface of the damping element, wherein the striking face comprises a first portion having a substantially constant thickness, wherein the front surface of the damping element comprises a geometric center, wherein the golf club head includes additional damping structures and materials to achieve desired acoustic characteristics.
US12226678B2	Golf club head Disclosed herein are various embodiments of a golf club head having improved mass distribution characteristics. The golf club head includes a body and a face positioned at a forward portion of the body. The golf club head also includes one or more mass elements positioned at predetermined locations about the head. The mass elements assist in achieving a desired relationship between the moment of inertia about a center of gravity x-axis and the moment of inertia about a center of gravity z-axis.
US12226675B2	Golf ball In a golf ball having a core, a cover, at least one intermediate layer therebetween, and a coating layer on the cover, the cover is formed of a transparent or translucent resin composition and the intermediate layer is formed of a resin composition. The sphere consisting of the core encased by the intermediate layer has specific lightness and chroma values in the Lab color space. The coating layer is composed of one or more layer, at least one of which contains an effect pigment having polarizing properties. Markings are provided inside of the coating layer and have a specific L value. During use, the ball retains a visual to familiarity close to that of a white ball. Up close, it is clearly discernible from a white ball; from a distance, it appears white and is highly visible.
US12226673B2	Exertion-driven physiological monitoring and prediction method and system Automated systems and methods are presented for determining the physiological response of human or suitable animal subjects to physical exertion. The methods and systems can include monitoring sensors that capture the motion of the subject along with corresponding physiological data, and can track such motion for the duration of a period of physical exertion. The system is able to acquire an initial stream of physiological data from the subject during a range of physical exertion activities that are representative of the events intended to be monitored with the proposed method and system, enabling a corresponding dynamic physiological response model to be created. The motion tracking system and physiological response model can then be used to predict the physiological response to physical exertion events under a prescribed framework, including applications during real-time event monitoring.
US12226668B2	System for unweighting a user and related methods of exercise The invention comprises a differential air pressure exercise system, comprising: a base; a pair of uprights on the base dividing the base into a front portion and a rear portion; a bulkhead extending between and vertically moveable relative to the uprights; a right arm and a left arm attached to the bulkhead extending from the bulkhead towards the base rear portion; a chamber support frame coupling element on the right arm and on the left arm; a hinge coupled to the bulkhead between the left and right arms; a chamber support frame extending between the left and right arms and coupled to the hinge to move between an engaged condition and a lowered condition.
US12226665B2	Door mount system for exercise devices A door mount system for securing exercise devices to a door for use by a user. The door mount system includes a support member, a securing member, an attachment member, and an adjustment member. The adjustment member is adapted to move the securing member. A securing member is adapted to press on the door to removably connect the support member to the door. The attachment member is adapted to connect to an exercise device. The door mount system may further include guide members and slots. The guide members slidably move in the slots to prevent rotation of the securing member. The attachment member may include one or more eyelets adapted to connect to the exercise device.
US12226664B2	Barbell safety device and methods Disclosed herein is a barbell safety device. The device mounts in pairs over the spaced stop collars of a barbell. The device is generally ‘T’ shaped and is used in an inverted ‘T’ orientation. The device comprises a stop collar receiver configured to house a portion of a loadable sleeve of a barbell as well as the stop collar of the barbell. A central support assembly extends from the stop collar receiver to an elongate base support. The central support assembly in preferred forms is telescoping and can be fixed by pins or other means at a variety of lengths to accommodate to the needs of the user. When the barbell is lowered during exercise, the base support will engage the ground and prevent further lowering of the barbell thereby protecting the user from injury.
US12226661B2	Wildfire defense spraying system for spraying environmentally-clean water-based liquid fire inhibitor to proactively form thin fire-inhibiting alkali metal salt crystalline coatings on sprayed property surfaces prior to the presence of wildfire A wildfire defense spraying system installed on property with combustible property surfaces, and adapted for spraying the combustible property surfaces with an environmentally-clean water-based liquid fire inhibitor for defending against wildfire by inhibiting fire ignition and flame spread caused by hot flying wildfire embers created during a wildfire storm. The wildfire defense spraying system includes: a storage tank containing a supply of environmentally-clean liquid fire inhibitor comprising an alkali metal salt of a nonpolymeric carboxylic acid, and triethyl citrate (TEC) dissolved in water according to a prespecified formulation, wherein the environmentally-clean water-based liquid fire inhibitor remains stable without the formation of solids at expected operating temperatures, and ready for immediate spraying on combustible surfaces. An electric-powered hydraulic pump system is connected to a remote power control switch employed to supply electrical power to the electric-powered hydraulic pump system. A plurality of spray heads are mounted about the property and any buildings thereon, and arranged in fluid communication with the storage tank and the hydraulic pump system. During operation, the hydraulic pump system automatically pumps environmentally-clean water-based liquid fire inhibitor from the storage tank and through the spray heads to generate a spray pattern of environmentally-clean water-based liquid fire inhibitor over all the combustible surfaces on the property. As water molecules in the sprayed environmentally-clean water-based liquid fire inhibitor evaporate to the environment, thin fire-inhibiting alkali metal salt crystalline coatings form on the combustible property surfaces, inhibiting fire ignition and flame spread in the presence of wildfire embers.
US12226653B2	Urinary catheter for detecting radiation Interstitial brachytherapy is a cancer treatment in which radioactive material is placed directly in the target tissue of the affected site using an afterloader. The accuracy of this placement is monitored in real time using a urinary catheter that locates the radioactive material according to the radiation levels measured by sensors in the walls of the urinary catheter. A scintillator that is embedded in the walls of the urinary catheter produces light when irradiated by the radioactive material. This light is proportional to the level of radiation at each location. The light produced by each scintillator is carried through optical fibers and then converted to an electrical signal that is proportional to the light and the radiation level at each location. The radioactive material is located according to the plurality of electrical signals. This location can be used as quality control feedback to the afterloader.
US12226650B2	Dermatological laser systems and methods for treatment of tissue with poor chromophore selectivity Dermatological systems and methods for providing a therapeutic laser treatment of tissue having poor chromophore selectivity using a laser source having a grating element to provide laser light having reduced linewidth. In some embodiments, the linewidth is reduced by at least half compared to the linewidth that would be provided in a system without the grating filter element. The linewidth may be reduced in some cases to 500 GHz or less, 300 GHz or less, or 200 Hz or less.
US12226649B2	Skin contouring using photo-responsive materials Methods, systems, and devices for integrated photo-responsive contouring treatment are described. Methods include identifying a region of skin corresponding to a contouring treatment of the skin. The region of skin may be provided with a photo-responsive material overlying a portion of the region of the skin. Methods may include identifying one or more treatment regions overlapping the photo-responsive material. The treatment regions may be identified at least in part to apply the contouring treatment. Methods may include determining an irradiation profile for each of the one or more treatment regions to contour each respective treatment region as part of applying the contouring treatment. Methods may also include irradiating the photo-responsive material at the one or more treatment regions in accordance with the respective irradiation profiles. Irradiating the photo-responsive material may induce a localized change in shape of the photo-responsive material in the respective treatment regions.
US12226644B2	Inhibition of onset of cardiac tachyarrhythmia with intercostal nerve stimulation An example medical device includes a plurality of electrodes, therapy delivery circuitry, and processing circuitry configured to control the therapy delivery circuitry to deliver electrical stimulation to an intercostal nerve of a patient via at least two of the plurality of electrodes, wherein the electrical stimulation is delivered with stimulation parameters configured to suppress ventricular tachyarrhythmia of the patient, wherein the stimulation parameters comprise a stimulation frequency less than or equal to 40 hertz (Hz).
US12226643B2	External pulse generator device and affixation device for trial nerve stimulation and methods of use Systems and methods for providing a trial neurostimulation to a patient for assessing suitability of a permanently implanted neurostimulation are provided herein. In one aspect, a trial neurostimulation system includes an EPG affixation device that secures the EPG to the patient when connected to a lead extending through a percutaneous incision to a target tissue location, while allowing for ready removal of the EPG for charging or bathing. In another aspect, the system includes an EPG provided with a multi-purpose connector receptacle through which the EPG can deliver neurostimulation therapy to an implanted lead or the EPG can be charged. In yet another aspect, the EPG can include a multi-purpose connector receptacle that is alternatingly connectable with a plurality of differing connector to facilitate differing types of therapies with one or more neurostimulation devices, ground patches or various other devices, such as charging or testing devices.
US12226635B2	Method and system for automated neuromodulation through machine learning An automated neuromodulation system which uses patient feedback during a training phase in combination with machine learning to automatically provide optimal nerve stimulation parameters based on the patient's needs without patient input. The automated neuromodulation system generally includes a lead which is implanted in a patient for treatment of a wide range of conditions, such as chronic pain. The patient is provided with a remote control through which the patient may provide either positive or negative feedback relating to how the patient is responding to electrical stimulation in different situations. A control unit monitors feedback from the patient as well as information and data from the time of feedback, such as the patient's position, orientation, speed of movement, or other considerations. Using machine learning, the control unit may process the feedback and data to formulate an optimized neuromodulation protocol and criteria which may be automatically applied to the patient.
US12226632B2	Method and apparatus for transdermal stimulation over the palmar and plantar surfaces The disclosure describes devices and methods for providing transdermal electrical stimulation therapy to a subject including positioning a stimulator electrode over a glabrous skin surface overlying a palm of the subject and delivering electrical stimulation via a pulse generator transdermally through the glabrous skin surface and to a target nerve or tissue within the hand to stimulate the target nerve or tissue within the hand so that pain felt by the subject is mitigated. The pulses generated during the electrical stimulation therapy may include pulses of two different magnitudes.
US12226629B2	Foraminal ligament anchor for application in DRG therapy In one embodiment, a system for stimulating the dorsal root ganglion of a patient comprises an elongate flexible implantable stimulation lead adapted to apply the stimulation pulses to the dorsal root ganglion of the patient, wherein the distal end comprises at least one electrode. A first segment and a second segment of the anchor are configured to transition between a collapsed configuration and deployed configuration. A central channel in the first segment and the second segment allows the anchor to be advanced along the stimulation lead from a proximal end toward the distal end while in the collapsed configuration. The central channel of each segment grips onto the stimulation lead in the deployed configuration so that the segment does not move from a deployed position on the stimulation lead. The first segment and the second segment may be deployed on opposite sides of foraminal ligament to anchor the stimulation lead.
US12226627B2	Devices and methods for neuromodulation In one aspect, a neuromodulation device is described herein. In some embodiments, a neuromodulation device comprises a chamber operable to receive a nerve, at least one electrode disposed in the chamber, and a channel defined by two walls. In some embodiments, the channel of the device is in fluid communication with an interior of the chamber and an external surface of the device. In another aspect, methods of neuromodulation are described herein. In some embodiments, methods described herein can use one or more neuromodulation devices described herein.
US12226623B2	Rotary blood pump A centrifugal blood pump includes a housing having a pumping chamber, an inlet having an inlet axis, and an outlet having an outlet axis. The inlet and the outlet are in fluid communication with the pumping chamber. The pump further includes an impeller rotatably disposed within the pumping chamber, and a strut connected to the housing at the inlet. The strut is connected to the housing at a circumferential position about the inlet axis such that a major axis of the strut and the outlet axis define a predetermined angle in a cross-sectional plane perpendicular to the inlet axis. The circumferential position of the strut relative the outlet axis reduces or eliminates damage to blood flowing around the strut.
US12226617B2	Integrated delivery device for continuous glucose sensor Systems and methods for integrating a continuous glucose sensor, including a receiver, a medicament delivery device, and optionally a single point glucose monitor are provided. Manual integrations provide for a physical association between the devices wherein a user (for example, patient or doctor) manually selects the amount, type, and/or time of delivery. Semi-automated integration of the devices includes integrations wherein an operable connection between the integrated components aids the user (for example, patient or doctor) in selecting, inputting, calculating, or validating the amount, type, or time of medicament delivery of glucose values, for example, by transmitting data to another component and thereby reducing the amount of user input required. Automated integration between the devices includes integrations wherein an operable connection between the integrated components provides for full control of the system without required user interaction.
US12226615B2	Method and device for the needle-free injecting of fluid into a substrate A method and a device for needleless injection of liquid into a substrate, in particular of a liquid pharmaceutical or cosmetic preparation into a biological tissue, which makes it possible in a particularly advantageous manner to reliably inject a particularly fine liquid jet into the substrate without a significant increase in the static pressure in the liquid during the injection process. According to the invention, this is achieved by first accelerating the liquid received in a liquid container together with the latter to an initial velocity before the movement of the liquid container is stopped again, while simultaneously ejecting the liquid from the liquid container through an outlet nozzle under at least partial retention of its movement. Preferably, the ejected liquid jet is set in rotation about its jet axis before it impinges on the substrate, so that the jet receives a helical movement and thus practically drills into the substrate without splashing away laterally.
US12226613B2	Auto-injector and related methods of use An injection device includes a carrier, a needle, a driver coupled to the needle, the driver being slidable relative to the carrier between a retracted configuration and a deployed configuration, a shuttle configured to move the driver between the retracted configuration and the deployed configuration, and a stop configured to move from a first configuration to a second configuration, wherein the stop is configured to maintain the driver in the deployed configuration, and movement of the stop from the first configuration to the second configuration allows the shuttle to move the driver from the deployed configuration to the retracted configuration.
US12226611B2	Pressure control apparatus Methods and apparatuses are disclosed for applying negative pressure to a wound site. In some embodiments, the apparatus comprises a source of negative pressure, a processing element, and a memory comprising instructions configured to, when executed on the processing element, cause the apparatus to attempt to generate, via the source of negative pressure, a desired negative pressure at the wound site. If the desired negative pressure has not been generated after a first predetermined period of time, the instructions cause the apparatus to: deactivate the source of negative pressure for a second predetermined period of time, and subsequently attempt to generate the desired negative pressure at the wound site.
US12226603B2	Rectal drain appliance A rectal drainage appliance is disclosed comprising a tubular element having an inflatable balloon at a distal end for anchoring the appliance in the rectum. The appliance includes one or more of: (i) first and second auxiliary lumens communicating with the inflatable balloon to provide independent inflation and pressure monitoring paths coupled to the balloon; (ii) a pressure state indicator defined by a mechanical element configured to flip between first and second states or shapes responsive to sensed pressure; and (iii) a collapsible auxiliary lumen larger than the inflation lumen, and configured to permit admission of irrigation fluid. The pressure state indicator may also be used in intestinal drains.
US12226594B2	Percutaneous urinary catheter A percutaneous urinary catheter is provided, including a proximal portion, a distal portion configured to be deployed in a kidney and/or renal pelvis of the urinary tract, and at least one lumen extending at least partially through the proximal portion of the percutaneous urinary catheter; and a negative pressure source in fluid communication with the at least one lumen, the negative pressure source being configured to draw fluid from the urinary tract into the at least one lumen of the percutaneous urinary catheter for removal of the fluid from the urinary tract.
US12226592B2	Catheter designs for enhanced column strength The objectives for the designs presented herein can be for a variably flexible and kink-resistant catheter for vascular applications. The designs benefit from good compressive and tensile stiffness. A braided wire support structure can be disposed around an inner liner and an outer layer having a plurality of outer jackets of variable durometer. A metallic reinforcing layer can be cut from a hypotube and be used as the primary structure for catheter stiffness, reducing the reliance on and number of jackets to transition stiffness changes along the length of the catheter. The metallic reinforcing layer can have one or more ribbon cut segments and one or more axial hole patterns laser cut into the hypotube to progressively evolve the stiffness from proximally regions with more column stiffness and distal regions with greater lateral flexibility. The polymer jackets can be reflowed to bond the structure together.
US12226591B2	Catheter with textured surface A catheter can have a textured outer body surface with protrusions and/or indentations that can reduce friction between the outer body surface and vascular anatomy or an inner lumen of another catheter in contact with the outer body surface. The catheter can include protrusions and/or indentations on an inner lumen surface that can reduce friction between the inner lumen surface and an outer body surface of another catheter within the example catheter. The protrusions can be filled with a lubricant or vasodilating drug, and the protrusions can be configured to break to release the fluid in response to forces on the protrusion during navigation through vascular anatomy and/or an inner lumen of another catheter. The catheter can include a metallic tubular reinforcing layer with openings through which the protrusions and/or indentations extend and/or protrusions and/or indentations shaped into the reinforcing layer.
US12226589B2	Multi-lumen shaft used with endoscopic device Briefly, in accordance with one embodiment, a multi-lumen shaft may be used to with an endoscopic instrument.
US12226585B2	Humidifier for breathing gas heating and humidification system A humidification canister for humidifying a breathing gas, the humidification canister includes a fluid supply configured to supply a fluid and a first gas flow path in fluid communication with the fluid supply. A first gas flow path is configured to humidify the breathing gas with the fluid. A second gas flow path at least partially surrounds the first gas flow path. A method of insulating a breathing gas in a humidification canister using a gas is also disclosed.
US12226584B2	Respiratory pressure treatment system A respiratory pressure therapy (RPT) device is disclosed for treatment of respiratory-related disorders. The RPT device includes a pressure generator, a pneumatic block, a chassis and a device outlet for delivering a supply of flow of gas to a patient interface. The RPT device also comprises an integrated humidifier including a water reservoir. An RPT device is also disclosed that includes a wireless data communication interface integrated with the housing and configured to connect to another device or a network.
US12226581B2	Headgear with covered edge A headgear assembly includes a strap of a first flexible material with an elongate edge, and a second flexible material folded around and running along the elongate edge. The second flexible material may be an elastic material. The second flexible material may also cover an intersection or joint in the first flexible material such that the first flexible material may be made from two flexible materials layered together or joined end to end.
US12226578B2	Patient interface with a seal-forming structure having varying thickness A cushion assembly for a patient interface including an elastomeric seal-forming structure that is shaped to be bisected by a sagittal plane having a line that is tangent to the elastomeric seal-forming structure at a superior tangent point and at an inferior tangent point. A saddle-shaped superior region of the elastomeric seal-forming structure straddles the sagittal plane and includes the superior tangent point. The elastomeric seal-forming structure transitions in a cylinder-shaped superior region from the saddle-shaped region to a dome-shaped superior region offset from the sagittal plane. In addition, an elastomeric wall thickness of the elastomeric seal-forming structure is greater in the cylinder-shaped superior region than in the saddle-shaped superior region and the dome-shaped superior region.
US12226576B2	Mask for preventing water from entering tracheal stoma A mask for preventing water from entering a tracheal stoma comprises a neck hanging part and a mask body connected with the neck hanging part. The mask body is worn on a tracheostomy patient through the neck hanging part. A concave space is formed on an inner side of the mask body, a plurality of air vents communicating with the concave space are formed in a lower half of an outer side of the mask body, and a plurality of inclined retaining walls are respectively located in the concave space and respectively connected to a top edge of each of the air vents, and the inclined retaining wall is capable of preventing the concave space from being seen when viewed directly through the air vents of the mask body. The mask of the invention is capable of greatly reducing a risk of water entering the tracheal stoma.
US12226573B2	Breathing control using high flow respiration assistance High flow therapy is used to treat Cheyne-Stokes respiration and other types of periodic respiration disorders by periodic application of high flow therapy, adjustment of high flow therapy flow rates and/or periodic additions of CO2 or O2 into the air flow provided to the patient.
US12226572B2	Systems and methods for delivery of therapeutic gas Therapy gas delivery systems that provide run-time-to-empty information to a user of the system and methods for administering therapeutic gas to a patient. The therapeutic gas delivery system may include a gas pressure sensor attachable to a therapeutic gas source that communicates therapeutic gas pressure data to a therapeutic gas delivery system controller, a gas temperature sensor positioned to measure gas temperature in the therapeutic gas source that communicates therapeutic gas temperature data to the therapeutic gas delivery system controller, at least one flow controller that communicates therapeutic gas flow rate data to the therapeutic gas delivery system controller, at least one flow sensor that communicates flow rate data to the therapeutic gas delivery system controller, and at least one display that communicates run-time-to-empty to a user of the therapeutic gas delivery system. The therapeutic gas delivery system controller of the system includes a processor that executes an algorithm to calculate the run-time-to-empty from the data received from the gas pressure sensor, temperature sensor, flow controller and flow sensor, and directs the result to the display.
US12226569B2	Systems for laparoscopic surgery This invention relates to a surgical smoke evacuation system for use in removing gases and smoke created in surgical procedures form within an insufflated surgical cavity. Such a system comprises a discharge assembly adapted to form a gases path, and having an end which in use is located within said surgical cavity so that gases and/or surgical smoke inside said cavity can pass out of said cavity and through said discharge assembly along said gases path, a flexible discharge limb having an operational site end and an outlet end, and a self-supporting wall defining a gases flow passage between said operational site end and said outlet end, in use said open operational site end sealingly connected to said discharge assembly so that said gases and/or surgical smoke can pass out of said discharge assembly and into said discharge limb, a filter connected in use to the outlet end of the discharge limb, at least part of said wall of the discharge limb formed from a breathable material, said breathable material allowing the passage of water vapour through the wall of the discharge limb without allowing the passage of liquid water or surgical smoke or other gases.
US12226563B2	Vascular access identification and validation system Techniques for vascular access identification and validation are disclosed. The techniques include: directly or indirectly acquiring an acquired value for a parameter that is a function of oxygen saturation (SO2) of a sample of blood in or obtained from a vascular access device (VAD) disposed in a subject; performing an evaluation of the acquired value at least by comparing the acquired value with one or more reference values; and responsive to the evaluation of the acquired value, assigning an identity classification to the VAD, wherein the identity classification is one of a central venous catheter (CVC), an arteriovenous access device (AVA), or another class of VAD.
US12226558B2	Dialysis system including a water treatment device A dialysis system is disclosed. An example dialysis system includes a water treatment device configured to provide purified water and a dialysis machine including a dialysate holding tank, and a dialysate mixing pump connected to a source of concentrate. The dialysis machine is configured to prepare dialysate using the purified water by receiving an indication that a batch of dialysate is needed, transmitting a first message to the water treatment device to begin providing the purified water, and causing the dialysate mixing pump to pump a concentrate from the source of concentrate for mixing with the purified water to form the dialysate for storage in the dialysate holding tank. After the batch of the dialysate has been stored to the dialysate holding tank, the dialysis machine transmits a second message to the water treatment device to stop providing the purified water.
US12226556B2	Dialysis machine having a holding device for holding and fixing at least one electronic terminal device A holding device for holding and fixing at least one electronic terminal device, in particular of the entertainment electronics type, during a medical treatment, more particularly dialysis treatment. The terminal device is or can be attached to a medical treatment apparatus, such as a dialysis machine, or to a patient bed. The holding device includes an integrated charging unit to supply the held and/or fixed electronic terminal device with power, more particularly from the medical treatment apparatus, with a protection circuit being integrated in the holding device to detect a defect of a terminal device that has just been connected. A charging unit includes an integral power supply unit on a dialysis machine or patient bed having a holding device.
US12226551B2	Drug release coating compositions In one aspect, the present disclosure pertains to elutable coating compositions that comprise an excipient comprising a bio-degradable or bio-stable polymer selected from a poly(lactic-co-glycolic acid) (PLGA) or methyl cellulose (MCC), a binding agent; a therapeutic agent. In some embodiments, the elutable coating compositions further comprise a solvent, in which case such compositions may be, for example, applied to a substrate in the form of a layer and subsequently dried, thereby forming an elutable coating on the substrate.
US12226550B2	Method of manufacturing a bioimplant Provided is a bioimplant which is capable to inhibit the biofilm formation over a long period of time after an operation. The bioimplant of the present invention comprises a base material of metal, ceramic, or plastic and a thermal spraying film of a calcium phosphate-based material formed at least partially thereon and the silver concentration in the thermal-spray film is 0.05 wt % to 3.00 wt %.
US12226549B2	Synergistically cooperative compositions useful for soft tissue augmentation, drug delivery and related fields The present invention relates to compositions based on: (a) a glycosaminoglycan or mixtures thereof; (b) one or more tocopherols, tocotrienols and mixtures thereof; and (c) a selected stabilizer. The composition is a solution, with the agents not chemically bound with each other. The component (a) can be hyaluronic acid (HA) or a salt thereof; the component (b) can be a polyether clathrate a cyclodextrin, or a combination of a fatty acid with an emulsifier; the component (c) can be α-tocopherols, β-tocopherols, γ-tocopherols, δ-tocopherols; α-tocotrienols, β-tocotrienols, γ-tocotrienols, δ-tocotrienols. Preferably component (c) is vitamin E. The agents strongly cooperate to provide enhanced and more stable viscoelastic properties, resulting in a product with higher resistance to thermal treatments like e.g. heat-sterilization, autoclaving, etc. The present compositions, optionally loaded with pharmaceutically and/or cosmetically active agents, are advantageously used in medical or cosmetic methods.
US12226548B2	Method for treating a tissue defect with a collagen-containing membrane The present invention relates to a method of producing a collagen membrane that has particular mechanical properties. In particular, the present invention relates to a method A of producing a collagen membrane comprising the steps of (i) isolating a collagen-containing tissue and incubating same in an ethanol solution; (ii) incubating the collagen-containing tissue from step (i) in a first solution comprising an inorganic salt and an anionic surfactant in order to denature non-collagenous proteins contained therein; (iii) incubating the collagen-containing tissue produced in step (ii) in a second solution comprising an inorganic acid until the collagen in said material is denatured; and (iv) incubating the collagen-containing tissue produced in step (iii) in a third solution comprising an inorganic acid with simultaneous mechanical stimulation for sufficient time to enable the collagen bundles in said collagen-containing tissue to align; wherein the mechanical stimulation comprises applying tension cyclically to the collagen-containing tissue.
US12226547B2	2D and 3D bioscaffold extracellular structural unit and tissue structure design and methods of manufacture A bioscaffold structure is provided, the bioscaffold comprising a plurality of connected unit cells, each unit cell comprising a plurality of filaments composed of an extracellular material containing Collagen I and Collagen III, wherein each of the plurality of unit cells includes at least one opening connected to an internal volume.
US12226546B2	Polyion complex polypeptide hydrogels and uses thereof Described herein are compositions comprising at least two diblock copolypeptides, wherein each copolypeptide has an ionic segment with the opposite charge from the other. The copolypeptides form β-sheet structured hydrogel assemblies via polyion complexation when mixed in aqueous media. As a result of their unique physical properties, the hydrogels are useful as cell suspension or cell culture media, in drug or cell delivery systems, in scaffolds for tissue repair, or as 3d-printable media.
US12226545B2	Micro injectable, low chromatic aberration intraocular lens materials The present disclosure is related to 2-(2-ethoxyethoxy)ethyl-functionalized polymers; their use in foldable intraocular lenses; and methods of making the same.
US12226544B2	Brain damage recovery material Provided is a non-tubular brain damage recovery material which is used to cover and/or fill a damaged part of the brain, the brain damage recovery material including: (A) a cross-linked body with which a bioabsorbable polysaccharide having a carboxyl group in a low endotoxin molecule is covalently bonded and cross-linked with at least one crosslinking reagent selected from among a compound represented by general formula (I) and salts thereof; and (B) a bioabsorbable polymer. R1HN—(CH2)n—NHR2 (I) [in the formula, R1 and R2 each independently represent a hydrogen atom or a group represented by formula of —COCH(NH2)—CH2]4—NH2, and n represents an integer from 2 to 18]. Accordingly, provided is a medical material which can recover a damaged part of the brain.
US12226539B2	Ultraviolet emitter for sanitation of aerosols A sanitation system for use in an application where contaminated aerosols are exhausted by a person includes at least one light source selectively operable to emit a light having a wavelength capable of neutralizing particles and that does not penetrate human skin. The sanitation system additionally includes a mounting system operable to mount said at least one light source. The mounting system is configured to direct the light emitted from the at least one light source toward the person such that the particles are neutralized as the particles are exhausted by the person.
US12226529B2	Stable nanolipoprotein particles and related compositions methods and systems Nanolipoprotein particles having at least a scaffold protein component and a membrane lipid component and related compositions, methods and systems are described. The membrane lipid component includes at least one or more membrane forming lipids, one or more polymerized lipids and/or one or more polymerizable lipids.
US12226522B2	Processes for production of tumor infiltrating lymphocytes and uses of the same in immunotherapy The present invention provides improved and/or shortened methods for expanding TILs and producing therapeutic populations of TILs, including novel methods for expanding TIL populations in a closed system that lead to improved efficacy, improved phenotype, and increased metabolic health of the TILs in a shorter time period, while allowing for reduced microbial contamination as well as decreased costs. Such TILs find use in therapeutic treatment regimens.
US12226520B2	Self-fueled particles for propulsion through flowing aqueous fluids A simple, self-propelling particle system is disclosed that can deliver a cargo through flowing aqueous solutions. This disclosure provides a non-aqueous composition comprising: (i) particles formed of a carbonate salt and having an average diameter of about 100 μm or less; and (ii) an acid in solid form. The particles may be associated with a cargo molecule or particle. In mouse models of severe hemorrhage, the propelled particles are able to deliver a procoagulant enzyme and halt bleeding.
US12226519B2	Oral compositions Compositions for use in oral hygiene contain a Lactobacillus helveticus strain. Compositions further containing a Lactobacillus plantarum strain, especially Lactobacillus plantarum SD5870, are particularly effective. The combination of Lactobacillus helveticus LAFTI L10 and Lactobacillus plantarum SD5870 synergistically improves oral hygiene. The compositions are particularly useful against dental caries.
US12226518B2	Dental polishing cup A dental polishing cup includes a body that defines a cup cavity for holding a dental treatment material, with the cup having an opening at its distal end. A portion of the body includes an enhanced-flexibility band (EFB) situated circumferentially at a certain distance from the distal end, the EFB providing a lesser stiffness of the body than other portions of the body that are situated lengthwise immediately distally and immediately proximately of the EFB.
US12226513B2	Cosmetic composition containing a rheological-modifying and stabilizing polymer blend The instant disclosure relates to a rheological-modifying and stabilizing polymer blend, cosmetic compositions comprising the polymer blend, and methods for stabilizing, for modifying viscosity, and for treating the skin using the polymer blend or using cosmetic compositions comprising the polymer blend. The rheological-modifying and stabilizing polymer blend comprises: (i) a carbomer; (ii) acrylates/C10-30 alkyl acrylate crosspolymer; and (iii) ammonium acryloyldimethyltaurate/steareth-25 methacrylate crosspolymer.
US12226511B2	Deodorant composition Cosmetic formulation with deodorant activity for topical application including vitamin E or an ester thereof, starch, sodium bicarbonate, zinc oxide and a cosmetically acceptable carrier is disclosed. The vitamin E ester is preferably alpha-tocopherol acetate, n-propionate or linoleate and the vitamin E or ester thereof and is present in an amount of 5-40% by weight of the weight of the formulation.
US12226509B2	Cosmetic composition comprising a pasty fatty substance and a non-ionic derivative of hydrophobic-modified cellulose Provided is a composition, in the form of an emulsion comprising a polyester from the esterification, with a polycarboxylic acid, of an aliphatic hydroxycarboxylic acid ester comprising at least two hydroxyl groups and at least one nonionic cellulose derivative comprising one or more hydrophobic substituents containing from 8 to 30 carbon atoms. Also provided is a composition comprising an active agent chosen from C-glucoside derivatives, a pasty fatty substance and a nonionic cellulose derivative comprising one or more hydrophobic substituents containing from 8 to 30 carbon atoms. Emulsions are made possible containing pasty fatty substances that are stable, even without an emulsifying surfactant or with a low content thereof (for example less than 3%), and which afford good sensory pleasure, even when the composition comprises a high content of pasty fatty substances. The emulsions can also contain active agents chosen from C-glucoside derivatives and cucurbic acid derivatives that are stable.
US12226492B2	Gene therapy for eosinophilic disorders Compositions and methods for eosinophilia in a mammal are provided. In one embodiment, the composition is a viral gene therapy vector, and a single dose of the vector reduces increased numbers of eosinophils in a mammal.
US12226491B2	Nano-satellite complexes The present invention provides, in some embodiments, methods, compositions, systems, and kits comprising nano-satellite complexes comprising: a core nanoparticle complex comprising a biocompatible coating surrounding a nanoparticle core; 3-25 satellite particles attached to, or absorbed to, said biocompatible coating; a plurality of antigenic peptides conjugated to, or absorbed to, said satellite particles; and at least one additional property. In other embodiments, provided herein are nano-satellite complexes comprising: a core nanoparticle complex comprising a biocompatible coating surrounding a nanoparticle core; a plurality of satellite particles attached to, or absorbed to, said biocompatible coating; a plurality of antigenic peptides conjugated to, or absorbed to, said satellite particles; and a plurality of LIGHT (TNFSF14) peptides conjugated to, or absorbed to, said satellite particles. In some embodiments, administration of the nanosatellite complexes to a subject with cancer achieves long-term cancer remission (e.g., when combined with an immune checkpoint inhibitor, such as αPD1).
US12226488B2	Nitroreductase-releasable pro-drugs and methods for using the same The present invention provides a nitroreductase-releasable pro-drug of the formula: where Ar1, m, n, Z, Y, L, and A are as defined herein, and methods for using and producing the same. Compound of formula I is useful in oral administration of the active pharmaceutical ingredient to the distal gut region of a subject to treat a wide variety of clinical conditions associated with distal gut region of a subject, such as colorectal cancer, inflammatory bowel disease (IBD), infectious diarrhea, bacterial infections, and bacterial overgrowth.
US12226487B2	Therapeutic derivatives of interleukin-22 The invention relates to novel derivatives of Interleukin-22 (IL-22), particularly those comprising a fatty acid covalently attached to an IL-22 protein, and their use in therapy.
US12226485B2	Injectable composition An injectable depot composition suitable for forming an in situ intramuscular implant is provided. The composition includes sterile biodegradable thermoplastic polymer of polylactic acid (PLA), solvent for the PLA, and drug. After administration to a subject, a corresponding implant administers 0.1-2 milligrams of nonsteroidal aromatase inhibitor every day throughout a dosing period of about six months to about one year. The composition is used to treat subjects in need thereof.
US12226484B2	Compositions having improved bioavailability of therapeutics The present specification discloses pharmaceutical composition disclosed herein comprises one or more therapeutic compounds, one or more glycerolipids, and one or more digestion enhancers. The disclosed glycerolipids comprise one or more hard fats and one or more liquid fats. The disclosed digestion enhancers comprise one or more bile acids, one or more phospholipids, one or more free C14-24 fatty acids, one or more free C14-24 fatty acid surfactants, or any combination thereof. The present specification also discloses methods and procedures to formulate the disclosed one or more therapeutic compounds into the disclosed pharmaceutical compositions.
US12226483B2	Phosphor-containing drug activator, suspension thereof, system containing the suspension, and methods for use A method for treating a disease in a subject in need thereof is provided involving infusing 8-methoxypsoralen (8-MOP) and a phosphor-containing drug activator into a diseased site in the subject; and delivering a dose of x-rays to the subject for production of the ultraviolet and visible light inside the subject to activate the photoactivatable drug and induce a persistent therapeutic response, the dose including a pulsed sequence of x-rays delivering from 0.5-2 Gy to the tumor, wherein the phosphor-containing drug activator includes an admixture of two or more phosphors capable of emitting ultraviolet and visible light upon interaction with x-rays; the two or more phosphors including Zn2SiO4:Mn2+ and (3Ca3(PO4)2Ca(F, Cl)2:Sb3+, Mn2+) at a ratio (Zn2SiO4:Mn2+):(3Ca3(PO4)2Ca(F, Cl)2:Sb3+, Mn2+)) of from 1:10 to 10:1; wherein each of the two or more phosphors have at least one coating selected from an ethyl cellulose coating or a diamond-like carbon coating.
US12226480B2	Combination drug including TLR7 agonist The present invention provides an agent for inducing effector memory T cell or an agent for inducing MHC class I for treating or preventing a cancer, comprising a TLR7 agonist which is used with an immune checkpoint inhibitor. And, the present invention also provides a medicament for treating or preventing a cancer, comprising a TLR7 agonist which is used with an immune checkpoint inhibitor.
US12226476B2	Helper epitope peptide and application thereof A helper epitope peptide is obtained by means of replacing one or two amino acid residues in the helper T cell epitope PADRE with 4-nitrophenylalanine. The helper epitope peptide is effective for enhancing the immunogenicity of an antigen or antigenic epitope or for preparing or constructing a vaccine, and a fusion antigen formed by connecting the helper epitope peptide to an antigen or an antigenic epitope.
US12226473B2	SARS-COV-2 antigen polypeptide, recombinant adeno-associated virus expressing the polypeptide, and vaccine containing the virus Disclosed are a SARS-COV-2 antigen polypeptide, a recombinant adeno-associated virus (rAAV) expressing the polypeptide, and a vaccine containing the virus. A sequence of the antigen polypeptide is shown in SEQ ID NO: 1 and SEQ ID NO: 2. A method for preparing the recombinant adeno-associated virus comprises co-incubating pHelper, pRep2Cap5, and an expression vector, transfecting a cell in the presence of polyethyleneimine as a transfection reagent; culturing the cell, then collecting the cell by centrifugation, performing lysis and purification to obtain a purified liquid comprising the recombinant adeno-associated virus. The rAAV is delivered and expressed in vivo to produce a fusion antigen polypeptide, induces the production of serum neutralizing antibodies, which have a neutralizing titer to the novel SARS-COV-2 coronavirus and are expressed continuously; the rAAV composition can be used to immunize humans against the novel coronavirus pneumonia COVID-19.
US12226468B2	Immunoreactive peptides Immunoreactive engineered polypeptides are provided. The engineered polypeptides can be used to diagnose or induce an immune response against E. chaffeensis or E. canis.
US12226466B2	Peptides and combination of peptides for use in immunotherapy against breast cancer and other cancers The present invention relates to peptides, proteins, nucleic acids and cells for use in immunotherapeutic methods. In particular, the present invention relates to the immunotherapy of cancer. The present invention furthermore relates to tumor-associated T-cell peptide epitopes, alone or in combination with other tumor-associated peptides that can for example serve as active pharmaceutical ingredients of vaccine compositions that stimulate anti-tumor immune responses, or to stimulate T cells ex vivo and transfer into patients. Peptides bound to molecules of the major histocompatibility complex (MHC), or peptides as such, can also be targets of antibodies, soluble T-cell receptors, and other binding molecules.
US12226463B2	Pharmaceutical composition, package and method for producing the same A pharmaceutical composition containing a lyophilized saccharide-degrading enzyme having excellent titer, and a package containing the pharmaceutical composition. The pharmaceutical composition is a unit dose formulation containing a lyophilized saccharide-degrading enzyme with a titer of not less than 0.3 unit/μg as an active ingredient, and contains the saccharide-degrading enzyme in an amount of not less than 2 μg and not more than 6 μg.
US12226462B2	Fibrinolytic composition and method of its preparation The present invention discloses modified forms of plasmin with advantageous properties. As compared to their natural unmodified form, these variants exhibit significantly modulated kinetics in terms of delayed inhibition characteristics in the presence of specific inhibitors, such as α2-antiplasmin (α2-AP). These include PEG-conjugated thiol derivatives of truncated plasmin with potential clinical applications in various regimens of thrombolytic therapies.
US12226461B2	Chimeric endolysin polypeptide, cluster 3b The invention relates to the field of antibacterial polypeptides, specifically to the field of antibacterial polypeptides having lytic activity for Staphylococcus. The invention relates to a novel chimeric endolysin polypeptide specifically targeting a Staphylococcus cell. The invention further relates to the use of said chimeric endolysin polypeptide as a disinfectant, as an antimicrobial cosmetic, for detection, such as in a diagnostic application and for medical use, such as for treating an individual suffering from a condition associated with a Staphylococcus infection.
US12226454B2	Pharmaceutical compositions and use thereof for relieving anticancer drug resistance and enhancing sensitivity of anticancer drug The present invention provides a novel modified chemokine peptide. The novel modified chemokine peptide can be combined with a targeted drug for treating cancer, especially for treating drug-resistant cancer, and inhibiting tumor growth more effectively.
US12226453B2	Eosinophils alleviate lung allograft rejection through their modulation of CD8+ t cells Provided are methods for enhancing immunosuppression in the lung of a subject, In some embodiments, the methods include administering to the subject a composition comprising at least one eosinophil recruiting agent, wherein the administering is in an amount and via a route of administration sufficient to induce recruitment of eosinophils to the lung of the subject to thereby enhance immunosuppression in the lung of the subject. Also provided are methods for enhancing tolerance to lung transplants, enhancing recruitment of eosinophils to the lungs, modulating T cell-mediated immune responses in the lungs, and reducing TCR signal transduction in the lungs.
US12226452B2	Polyhedrin-based slow release growth factor system for neuroprotection of retinal ganglion cell neurons Described herein are polyhedrin-based slow release growth factor systems and methods of use thereof for neuroprotection of host and donor retinal ganglion cell neurons.
US12226451B2	FGF-21 formulations The present application provides pharmaceutical formulations comprising a FGF-21 polypeptide, e.g., a modified FGF-21 polypeptide such as PEG-FGF-21, and one or more stabilizers such as the chelator DPTA. The formulations can be can further stabilized by including a surfactant such as polysorbate 80 and/or adjusting the pH to about 7.1. Also provided are methods of manufacture, methods of treatment, and kits.
US12226450B2	Peptides and methods for treating disease Bioactive peptides and methods for their use for preventing, treating, and/or reducing the incidence and/or symptoms of an autoimmune disease or disorder that may result from chronic inflammation, damage to β-cells of the pancreas, and other conditions that are implicated by the CD40-CD154 dyad. In particular, small peptides that are capable of interacting with CD40, thereby interfering with the ability of CD40 to interact with CD154, which impacts inflammation, autoimmunity, and disease progression. The use of such peptides in reducing diabetes mellitus, and in particular, the autoimmune inflammatory response that may be a driving factor thereof. Methods and materials for preventing and modulating diabetes mellitus and autoimmune diseases especially in dogs, cats, and horses.
US12226449B2	Materials and methods for the prevention of rheumatoid arthritis Compositions and methods for preventing, treating, or delaying the onset of rheumatoid arthritis involving 14-3-3ζ, are described. Provided is a method for preventing, treating, or delaying the onset of rheumatoid arthritis, the method comprising administering an effective amount of 14-3-3ζ, or a variant thereof, to a subject at risk for developing rheumatoid arthritis, and preventing, treating, or delaying the onset of rheumatoid arthritis in the subject.
US12226448B2	Peanut oral immunotherapy dosing schedule for missed doses The present disclosure relates to improved oral immunotherapy methods for treating peanut allergy. In certain embodiments, the disclosure provides methods for continuing an oral immunotherapy for the treatment of a peanut allergy after missing a scheduled oral administration of one or more consecutive doses of a pharmaceutical composition comprising peanut protein.
US12226447B2	Composition comprising an algal proteoglycan extract and use thereof The present application provides use of an algal proteoglycan extract and a composition comprising the same in treating or preventing tumor, pain, inflammation or diseases mediated by inflammatory factors.
US12226443B2	Polyphenol composition and method of its use and manufacture in the treatment of metabolic disorders The invention provides a polyphenolic composition and method for its use and manufacture in the treatment of metabolic disorders. The active agents of the composition can include flavonoids and anthocyanins. The active agents can be obtained from rose petal extract, including Rosa multiflora rose petal extract. The composition finds use in the treatment of obesity and complications associated with obesity.
US12226441B2	Composition for inhibiting intestinal permeability, treating leaky gut related diseases and/or preventing leaky gut related diseases A composition for inhibiting intestinal permeability, treating leaky gut related diseases and/or preventing leaky gut related diseases including a Chinese herbal compound material or a Chinese herbal compound extract is provided. The Chinese herbal compound material includes Ganoderma, red jujube, longan and lotus seed. Moreover, the Chinese herbal compound extract includes a Ganoderma extract, a red jujube extract, a longan extract and a lotus seed extract.
US12226437B2	Method for enhancing expression of insulin like growth factor 1 receptor in umbilical cord mesenchymal stem cell expressing IGF1R and method for obtaining multipotent umbilical cord mesenchymal stem cell A method for enhancing an expression of insulin like growth factor 1 receptor in an umbilical cord mesenchymal stem cell is provided. The method includes culturing the umbilical cord mesenchymal stem cell expressing insulin-like growth factor 1 receptor in a medium containing platelet-derived growth factor BB (PDGF-BB) to enhance the expression of insulin like growth factor 1 receptor in the umbilical cord mesenchymal stem cell.
US12226431B2	Aerosol and topical administration of a formulation containing cyclodextrin, quercetin and zinc, in combination or separately, to mitigate infection by enveloped viruses The invention provides the use of a formulation containing cyclodextrine, quercetin and zinc, at appropriate concentrations to mitigate infections by enveloped viruses like SARS-COV-2, influenza and HIV/AIDS, when administered via pulmonary and dermal route. While the different forms of cyclodextrin prevent the entry of coated virus into host cells by extracting and sequestering cholesterol molecules at the virus coat and at the host cell plasma membrane, the natural plant-based ionophore quercetin in the formulation, enables cellular entry of zinc, inhibiting viral replication by altering polymerase activity in the host cell. Hence cyclodextrine, and quercetin plus zinc, either in combination or in tandem order of administration, serves both as prophylactic and therapeutic.
US12226425B2	Inhibitors of ARG1 and/or ARG2 Compounds that are inhibitors of at least one of ARG1 and ARG2, and compositions containing the compounds and methods for synthesizing the compounds, are described herein. The use of such compounds and compositions for the treatment of a diverse array of diseases, disorders, and conditions, including cancer- and immune-related disorders that are mediated, at least in part, by ARG1 and ARG2 are also described herein.
US12226421B2	Nefopam dosage forms and methods of treatment Dosage forms containing nefopam, nefopam metabolite, nefopam prodrug, isomers thereof or combinations of the foregoing, optionally an acid, and optionally an opioid analgesic and/or NSAID, and associated methods for treating various types of pain in patients.
US12226420B2	Theramutein modultors This invention relates to agents that are inhibitors or activators of variant forms of endogenous proteins and novel methods of identifying such variants. Of particular interest are inhibitors and activators of endogenous protein variants, encoded by genes which have mutated, which variants often arise or are at least first identified as having arisen following exposure to a chemical agent which is known to be an inhibitor or activator of the corresponding unmutated endogenous protein.
US12226418B2	Dosing regimen for the treatment of PI3K related disorders The present application provides methods of treating PI3Kδ related disorders using pyrazolopyrimidine derivatives.
US12226416B2	Methods and materials for improving arteriovenous fistula maturation and maintaining arteriovenous fistula functionality This document provides methods and materials for improving arteriovenous fistula (AVF) maturation and/or maintaining AVF functionality. For example, methods and materials for using one or more senolytic agents to improve AVF maturation, to maintain AVF functionality, and/or to maintain the patency of an AVF are provided. Methods and materials for using one or more senolytic agents to maintain functionality and/or patency of a venous graft (e.g., a venous graft that bypasses an occluded artery) also are provided.
US12226412B2	Heteroaryl-ketone fused azadecalin glucocorticoid receptor modulators The present invention provides heteroaryl ketone fused azadecalin compounds and methods of using the compounds as glucocorticoid receptor modulators, including their use for treating amyotrophic lateral sclerosis (ALS).
US12226408B2	Co-crystals Co-crystals of itanapraced; methods of preparation of the co-crystals; uses of the co-crystals as APIs; formulations containing the co-crystals; uses of the co-crystals and formulations for prevention and treatment of neurodegeneration disorders, infections, dementias, inflammation, and injuries; and methods of prevention and treatment of neurodegeneration disorders, infections, dementias, inflammation, and injuries are described.
US12226407B2	Aerosol pirfenidone and pyridone analog compounds and uses thereof Disclosed herein are formulations of pirfenidone or pyridone analog compounds for aerosolization and use of such formulations for aerosol administration of pirfenidone or pyridone analog compounds for the prevention or treatment of various fibrotic and inflammatory diseases, including disease associated with the lung, heart, kidney, liver, eye and central nervous system. In some embodiments, pirfenidone or pyridone analog compound formulations and delivery options described herein allow for efficacious local delivery of pirfenidone or pyridone analog compound. Compositions include all formulations, kits, and device combinations described herein. Methods include inhalation procedures, indications and manufacturing processes for production and use of the compositions described.
US12226406B2	Compositions of 1-(4-bromo-5-(1-ethyl-7-(methylamino)-2-oxo-1,2-dihydro-1,6-naphthyridin-3-yl)-2-fluoropheyl)-3-phenylurea Provided herein are low impurity compositions comprising a compound represented by Formula (I): which are useful in the treatment of disorders related to the activity of the c-KIT and PDGFRα kinases, and oncogenic forms thereof.
US12226402B2	Dual inhibitors of TIM-3 and PD-1 pathways The present disclosure relates to 3-substituted 1,2,4-oxadiazole compounds and their derivatives, which are useful as T-cell immunoglobulin and mucin-domain containing-3 (TIM-3) inhibitors or as dual inhibitors of TIM-3 and the programmed cell death 1 (PD-1) signaling pathway. The disclosure also relates to treatment of disorders by inhibiting an immunosuppressive signal induced by TIM-3, PD-1, PD-L1, and/or PD-L2.
US12226401B2	Molecular genetic approach to treatment and diagnosis of alcohol and drug dependence Compositions and methods are provided that are useful for diagnosing, treating, and monitoring alcohol dependence and disorders, susceptibility to alcohol dependence disorders, as well as drug related dependence and disorders. The methods include treating patients with an antagonist of the serotonin receptor 5-HT3 for such disorders, wherein the patient's serotonin transporter gene SLC6A4 is known to have particular genotypes.
US12226400B2	Neuroprotective disruption of Kv2.1/syntaxin interaction by small molecules Disclosed herein are small molecule compounds capable of disrupting Kv2.1-syntaxin binding. The compounds are useful for treating a variety of neurological disorders, diseases, and injuries.
US12226399B2	Oral aqueous suspension formulation comprising carbamate compound The present disclosure relates to an aqueous formulation comprising as an active ingredient a carbamate compound of Formula 1, or a pharmaceutically acceptable salt, solvate or hydrate thereof, poloxamer, and an aqueous carrier, wherein the aqueous formulation is in the form of a suspension formulation.
US12226395B2	Composition for preventing or treating neurodegenerative diseases, containing diterpene-based compound The present invention relates to a pharmaceutical composition for preventing or treating neurodegenerative diseases comprising a diterpene, or a pharmaceutically acceptable salt thereof. Specifically, the diterpene of the present invention can prevent or treat neurodegenerative diseases caused by inhibition of Nurr1 activity by activating Nurr1 and inhibiting the inflammatory response.
US12226389B2	Modified release gamma-hydroxybutyrate formulations having improved pharmacokinetics Modified release formulations of gamma-hydroxybutyrate having improved dissolution and pharmacokinetic properties are provided, and therapeutic uses thereof.
US12226386B2	Compositions and methods for treating biofilms The disclosure provides compositions comprising amino acids, individually and in combination, and methods of making the compositions and methods of using the compositions as pharmaceutically active agents to, inter alia, treat disease in animals, including humans.
US12226382B2	Methods for treating microglial dysfunction Among the various aspects of the present disclosure is the provision of methods of treating a microglial dysfunction-associated diseases, disorder, and conditions. The present disclosure provides for a method for treating microglial dysfunction in a subject having a microglial dysfunction-associated neurodegenerative disease comprising administering to a subject a therapeutically effective amount of a microglial rescuing agent. The present disclosure also provides for a method of reversing neuronal damage in a subject having a microglial dysfunction-associated neurodegenerative disease, wherein the microglial dysfunction-associated neurodegenerative disease is characterized by a single nucleotide polymorphisms (SNPs) or mutation in Trem2 or ApoE affecting microglial functions.
US12226379B2	Highly sustainable compositions for modulation of gene expression in human skin, and methods of production thereof Formulations containing biologically-produced, high-purity R-mevalonolactone are provided for modulating the expression of genes and metabolism related to epidermal turnover, hyaluronic acid synthesis, barrier function, anti-aging elasticity, extracellular matrix degradation, inflammation, stress, and pigmentation in human skin. The biologically-produced, high-purity R-mevalonolactone may be used as an ingredient in pharmaceutical, food, or cosmetic products and may be applied topically or ingested for modulation of gene expression and metabolism.
US12226377B2	Gamma-hydroxybutyrate compositions having improved pharmacokinetics in the fed state Oral pharmaceutical compositions of sodium oxybate having improved pharmacokinetic properties when administered less than two hours after eating are provided, and therapeutic uses thereof.
US12226376B2	Multidrug pain management package Disclosed herein is a multidrug pain management package to dispense two or more medicaments to treat pain comprising a primary n-polygon, and one or more concentric m-polygons, wherein each side of the n-polygon and m-polygons have at least n or m-medicament chambers capable of holding the two or more medicaments. Also disclosed herein is a multidrug pain management package comprising a disk, wherein the disk is divided into equally spaced regions, and wherein each region has chambers capable of holding medicaments. Also disclosed herein are single formulations to treat pain.

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