Document Document Title
US11634766B2 Methods and compositions for analyzing nucleic acids
Provided herein include methods and compositions for analyzing nucleic acid in individual cells. In some embodiments, the methods herein include generating, within individual cells, fragmented cellular genomic DNA and cDNA copies of cellular RNA molecules, barcoding the fragmented genomic DNA and the cDNA within each cell such that the genomic DNA and the cDNA from the same cell receive the same unique barcode sequence, isolating the barcoded genomic DNA and cDNA, and characterizing one or more features of the individual cells based, at least in part, on sequencing of the isolated barcoded genomic DNA and the cDNA.
US11634758B2 Nucleic acid amplification and detection apparatus and method
A nucleic acid amplification and detection apparatus, including: a support configured to receive a plurality of reaction vessels containing respective samples of one or more nucleic acids to be amplified, the support being rotatable about an axis of rotation and the reaction vessels being received in the support at respective receiving locations distributed about the axis of rotation; a temperature control component thermally coupled to the support and configured to control the temperature of the support in order to amplify the nucleic acids contained in the reaction vessels while received in the support; one or more measurement components configured to measure one or more characteristics of the nucleic acids within the reaction vessels at respective measurement locations distributed about the axis of rotation; an actuator coupled to the support and configured to rotate the support about the axis of rotation; and a sample position controller coupled to the actuator and being configured to rotate the support about the axis of rotation so as to position a selected one of the plurality of reaction vessels to a selected one of the measurement locations to allow a corresponding one of the measurement components to perform a corresponding measurement on the corresponding sample.
US11634756B2 Spatially encoded biological assays
The present invention provides assays and assay systems for use in spatially encoded biological assays. The invention provides an assay system comprising an assay capable of high levels of multiplexing where reagents are provided to a biological sample in defined spatial patterns; instrumentation capable of controlled delivery of reagents according to the spatial patterns; and a decoding scheme providing a readout that is digital in nature.
US11634750B2 Methods and compositions for preparing polynucleotides
Provided herein are methods, compositions, and kits for forming amplification products. In various embodiments provided herein, transposomes comprising transposases are used in forming tagged polynucleotides for downstream amplification and polynucleotide processing steps.
US11634744B2 Methods and materials for assessing and treating arthritis
This document provides methods and materials involved in assessing mammals (e.g., humans) for arthritis. For example, methods and materials for assessing a mammal's gut microbial diversity to identify the mammal as having arthritis (e.g., rheumatoid arthritis) are provided. This document also provides methods and materials involved in treating arthritis.
US11634742B2 Compositions of DNA molecules, methods of making therefor, and methods of use thereof
Provided herein are double strand DNA molecules comprising inverted repeats, expression cassette and one or more restriction sites for nicking endonucleases, the methods of use thereof, and the methods of making therefor.
US11634741B2 Synthesis of L-nucleic acids by means of an enzyme
The present invention is related to a method for adding one or more L-nucleotides to the 3′end of a first L-nucleic acid, wherein the method comprises the step of reacting the one or more L-nucleotides with the first L-nucleic acid in the presence of a protein comprising a mutant enzymatic activity exhibiting moiety, wherein the enzymatic activity is capable of adding one or more L-nucleotides to the 3′ end of the first L-nucleic acid, wherein the mutant enzymatic activity exhibiting moiety comprises an amino acid sequence, wherein the amino acids of the amino acid sequence are D-amino acids, wherein the mutant enzymatic activity exhibiting moiety is a variant of an enzymatic activity exhibiting moiety, wherein the enzymatic activity exhibiting moiety consists of an amino acid sequence according to SEQ ID NO: 15 and wherein the amino acids of the amino acid sequence according to SEQ ID NO: 15 are D-amino acids, wherein the amino acid sequence of the mutant enzymatic activity exhibiting moiety differs from the amino acid sequence of the enzymatic activity exhibiting moiety consisting of an amino acid sequence according to SEQ ID NO: 15 at least at one amino acid position, preferably at three amino acid positions, and/or wherein the amino acid sequence of the mutant enzymatic activity exhibiting moiety is a truncated form of an amino acid sequence according to SEQ ID NO: 15, and wherein the amino acid sequence of the mutant enzymatic activity exhibiting moiety is different from an amino acid sequence according to any of SEQ ID NOs 15 to 22 and 51.
US11634738B2 Use of marine algae for co-producing alkenones, alkenone derivatives, and co-products
A method comprising a series of selective extraction techniques for the parallel production of biodiesel and isolation of several valuable co-products including an alkenone hydrocarbon mixture of the kerosene/jet fuel range (primarily C10-, C12-, and C17-hydrocarbons) and fucoxanthin, a high-valued carotenoid, from the marine alkenone-producing microalgae Isochrysis.
US11634737B2 Oleic acid production in yeast
Disclosed are transformed cells comprising one or more genetic modifications that affect the lipid content of the cell, e.g., by increasing the concentration of oleic acid in the cell relative to an unmodified cell of the same type. Also disclosed are methods for modifying the lipid content of a cell by increasing the activity of one or more proteins in the cell and/or by decreasing the activity of one or more proteins in the same cell.
US11634736B2 Methods and materials for the biosynthesis of compounds involved in the tricarboxylic acid cycle and derivatives and compounds related thereto
Methods and materials for the production of compounds involved in the TCA cycle, and/or derivatives thereof and/or compounds related thereto are provided. Also provided are products produced in accordance with these methods and materials.
US11634731B2 Using truncated guide RNAs (tru-gRNAs) to increase specificity for RNA-guided genome editing
Methods for increasing specificity of RNA-guided genome editing, e.g., editing using CRISPR/Cas9 systems, using truncated guide RNAs (tru-gRNAs).
US11634729B2 SEC modified strains for improved secretion of recombinant proteins
Disclosed herein are modified strains for improving secretion of recombinantly expressed products secreted from a host organism with improved growth and productivity characteristics, as well as methods of using the modified strains.
US11634728B2 Adeno-associated virus (AAV) vector having hybrid HGF gene introduced thereto
The present invention relates to an AAV vector carrying a predetermined hybrid HGF gene sequence. Use of the AAV vector of the present invention allows a hybrid HGF gene to be delivered to a subject at a high delivery yield.
US11634726B2 Cas9 nucleic acid molecules and their use
Described are recombinant nucleic acid molecules for increased expression of Cas9 in human liver. In some embodiments, the recombinant nucleic acid molecules are provided in compositions and methods for gene editing, specifically using Clustered Regularly Interspaced Short Palindromic Repeats (CRISPR).
US11634715B2 Methods and compositions for treating bile duct paucity-associated conditions
This disclosure relates to oligonucleotides, compositions and methods useful for reducing CTNNB1 expression, particularly in hepatocytes, for the treatment of bile duct paucity-associated conditions. Disclosed oligonucleotides for the reduction of CTNNB1 expression may be double-stranded or single-stranded, and may be modified for improved characteristics such as stronger resistance to nucleases and lower immunogenicity. Disclosed oligonucleotides for the reduction of CTNNB1 expression may also include targeting ligands to target a particular cell or organ, such as the hepatocytes of the liver.
US11634709B2 Methods for preparing analytes and related kits
Provided herein are methods for preparing and treating an analyte (e.g., a macromolecule or a plurality of macromolecules, peptides, polypeptides, and proteins) for analysis. In some embodiments, the analyte is prepared and treated in a method that includes the use of bait and capture nucleic acids, solid supports, and reaction mixtures including the bait and capture nucleic acids. In some embodiments, the analyte is coupled to a solid support. Also provided are kits containing components for performing the provided methods for preparing the analytes. In some embodiments, the methods are for preparing an analyte for sequencing. Provided herein are methods for preparing and treating an analyte (e.g., a macromolecule or a plurality of macromolecules, peptides, polypeptides, and proteins) for analysis. In some embodiments, the analyte is prepared and treated in a method that includes the use of bait and capture nucleic acids, solid supports, and reaction mixtures including the bait and capture nucleic acids. In some embodiments, the analyte is coupled to a solid support. Also provided are kits containing components for performing the provided methods for preparing the analytes. In some embodiments, the methods are for preparing an analyte for sequencing.
US11634706B2 Single-molecule phenotype analysis
Aspects of the present disclosure include methods of producing modified polypeptides and modified polypeptide-ribosome or polypeptide-mRNA complexes, and methods of screening polynucleotide and polypeptide libraries. The present disclosure also provides polypeptide libraries useful in screening for single molecule phenotypes. Also provided are kits useful for producing polypeptides capable of being modified using methods disclosed herein.
US11634702B2 Cell signaling pathway activation by local AC electric field
A method for activating a cell-signaling pathway of interest in a cell, including applying a time-modulated localized alternating current electrical field to the cell, wherein the amplitude and frequency of the localized alternating current electrical field is selected to activate the cell signaling pathway of interest, thereby activating the cell signaling pathway.
US11634701B2 Metabolic pathways with increased carbon yield
The present invention relates to the conversion of a carbon source into acetyl phosphate with increased carbon yield. In particular, the invention provides metabolically engineered micro-organisms capable of producing acetyl phosphate from a carbon source with increased carbon yield, which micro-organisms have been transformed with at least one exogenous nucleic acid encoding a phosphoketolase having sedoheptulose-7-phosphate phosphoketolase activity and which are further genetically modified to have eliminated transketolase activity. The invention also provides methods for the production of chemicals using said micro-organisms.
US11634697B2 Polymerases, compositions, and methods of use
Presented herein are altered polymerase enzymes for improved incorporation of nucleotides and nucleotide analogues, in particular altered polymerases that maintain high fidelity under reduced incorporation times, as well as methods and kits using the same.
US11634692B2 Aldehyde dehydrogenase variants and methods of using same
The invention provides polypeptides and encoding nucleic acids of aldehyde dehydrogenase variants. The invention also provides cells expressing aldehyde dehydrogenase variants. The invention further provides methods for producing 3-hydroxybutyraldehyde (3-HBal) and/or 1,3-butanediol (1,3-BDO), or an ester or amide thereof, comprising culturing cells expressing an aldehyde dehydrogenase variant or using lysates of such cells. The invention additional provides methods for producing 4-hydroxybutyraldehyde (4-HBal) and/or 1,4-butanediol (1,4-BDO), or an ester or amide thereof, comprising culturing cells expressing an aldehyde dehydrogenase variant or using lysates of such cells.
US11634687B2 Human otic progenitor identification and isolation
The present invention relates generally to the identification and isolation of human otic progenitor cells. More specifically, the present invention relates to a method of using cell markers to identify and isolate human otic progenitor cells from a mixed population of cells, methods of enrichment and production of human otic progenitor cells, and associated kits for use in identification and/or isolation of human otic progenitor cells, wherein the cell markers are selected from SSEA1 (CD15), disialoganglioside GD3, TRA-2-49 (liver/bone/kidney alkaline phosphatase), SSEA4, ganglioside GD2 and CD141.
US11634685B2 Sporichthyaceae microorganism and use thereof
Provided is a microorganism of the genus Epidermidibacterium belonging to the family Sporichthyaceae, or a culture thereof, or a composition for preventing, improving, or treating skin conditions or inflammatory diseases including the same.
US11634681B2 Incubator with air curtain
An incubator for cell and tissue culture under controlled atmospheric conditions has a primary air flow control device that forms a primary, preferably laminar flow, air veil across an opening that allows access to the cells or tissue cultures disposed within the incubator. Preferably, most if not all of the air in the primary (laminar flow) air veil is recirculated, and a secondary air flow control device is used that forms a secondary, preferably laminar flow, air veil between the primary (laminar flow) air veil and a user of the incubator.
US11634680B2 Process and system for propagating cell cultures while preventing lactate accumulation
A predictive model is described that can predict parameter concentrations in the future based on initial, measured concentrations and historical data. A plurality of multivariate techniques can be used to construct the predictive model capable of forecasting concentrations over multiple and diverse cell lines. The predictive model is also scalable. In one embodiment, a future lactate concentration trajectory is determined and at least one condition within a bioreactor is changed or modified to maintain lactate concentration within desired ranges.
US11634677B2 Coating a bioreactor in a cell expansion system
Embodiments described herein generally provide for the expansion of cells in a cell expansion system using an active promotion of a coating agent(s) to a cell growth surface in some embodiments. A coating agent may be applied to a surface, such as the cell growth surface of a hollow fiber in a bioreactor, by controlling the movement of a fluid in which a coating agent is suspended, by changing flow rates, by changing flow directions, by rotation of the bioreactor, and/or combinations thereof.
US11634670B2 Cleaning agent for semiconductor component, and use thereof
A semiconductor cleaning agent containing a sulfonic acid group-containing polymer, wherein a content of at least one metal selected from the group consisting of Na, Al, K, Ca and Fe is 0.7 ppm or less.
US11634664B2 Method for preparing an inverse emulsion comprising two cationic polymers
This invention relates to a process for preparing an inverse emulsion comprising mixing an aqueous solution comprising a water-soluble (co)polymer A synthesized from at least one cationic monomer and an inverse EMI 2 emulsion comprising a water-soluble (co)polymer B synthesized from at least one cationic monomer, optionally followed by distillation.This invention also relates to the inverse emulsion thus obtained, a detergent or cosmetic or softening composition comprising such an inverse emulsion, as well as the use of such an inverse emulsion to improve the softening properties of a fabric softening composition.
US11634662B2 Liquid detergent compositions with improved rheology
A composition that includes of detersive surfactant, external structurant or thickener, and C4-C10 alkyl branched alcohol.
US11634660B2 Detergent composition for textile products
The present invention provides a detergent composition for textile products, containing the following component (A) and component (B): component (A): an internal olefin sulfonate having 16 or more and 18 or less carbons; and component (B): an alkyl sulfate having 12 or more and 14 or less carbons.
US11634653B2 Droplet for fuels
A droplet formation for fuels is disclosed. The droplet formation for fuels includes an amphiphile. The droplet formation for fuels further includes at least one of an extensional viscosity modifier and a viscosity modifier. The droplet formation for fuels further includes a hydrophilic portion. The droplet formation for fuels further includes a hydrophobic portion. The droplet, including the hydrophilic portion and the hydrophobic portion, includes characteristics selected for beneficial combustion properties. The selected characteristics include flash point, autoignition temperature, density, viscosity, miscibility, size, combustion temperature, organic properties, inorganic properties, zwitterionic properties, micelle properties, and particulate properties.
US11634649B2 Integrated pyrolysis and hydrocracking units for crude oil to chemicals
Integrated pyrolysis and hydrocracking systems and processes for efficiently cracking of hydrocarbon mixtures, such as mixtures including compounds having a normal boiling temperature of greater than 450° C., 500° C., or even greater than 550° C., such as whole crudes for example, are disclosed.
US11634648B2 Optimized reactor configuration for optimal performance of the aromax catalyst for aromatics synthesis
A naphtha reforming reactor system comprising a first reactor comprising a first inlet and a first outlet, wherein the first reactor is configured to operate as an adiabatic reactor, and wherein the first reactor comprises a first naphtha reforming catalyst; and a second reactor comprising a second inlet and a second outlet, wherein the second inlet is in fluid communication with the first outlet of the first reactor, wherein the second reactor is configured to operate as an isothermal reactor, and wherein the second reactor comprises a plurality of tubes disposed within a reactor furnace, a heat source configured to heat the interior of the reactor furnace; and a second naphtha reforming catalyst disposed within the plurality of tubes, wherein the first naphtha reforming catalyst and the second naphtha reforming catalyst are the same or different.
US11634643B2 Wetting and anti-foaming agent
A wetting agent according to Formula (I): wherein R1 is selected from a branched alkyl group or linear alkyl group or a cycloaliphatic group or an aromatic group, each having 6 to 15 carbon atoms; R2 is selected from hydrogen, methyl, or ethyl; R3 is selected from hydrogen, methyl, or ethyl; R4 is selected from hydrogen, methyl, or ethyl; R5 is selected from methyl or ethyl; x ranges from 0 to 5; y ranges from 0 to 10; z ranges from 1 to 10; with the proviso that when x ranges from 1 to 5, R2 is different from R3; and with the proviso that when x=0, R3 is different from R4. The wetting agent also imparts anti-foam properties to aqueous solutions while reducing surface tension.
US11634641B2 Aerogel compositions for high temperature applications
Aerogel materials, aerogel composites, and the like may be improved by the addition of opacifiers to reduce the radiative component of heat transfer. Such aerogel materials, aerogel composites, and the like may also be treated to impart or improve hydrophobicity. Such aerogel materials and methods of manufacturing the same are described.
US11634638B2 Liquid crystal composition, reflective layer, method for producing reflective layer, and copolymer
Provided are a liquid crystal composition which has excellent planarity in a case of being formed into a coating film and is also capable of forming a reflective layer having excellent diffuse reflectivity, a reflective layer that is formed using the liquid crystal composition, and a method for producing a reflective layer. Provided also is a copolymer that can be used as an alignment control agent for a liquid crystal compound.
US11634632B2 Composition for etching
The disclosure is related to a composition for etching, a method for manufacturing the composition, and a method for fabricating a semiconductor using the same. The composition may include a first inorganic acid, at least one of silane inorganic acid salts produced by reaction between a second inorganic acid and a silane compound, and a solvent. The second inorganic acid may be at least one selected from the group consisting of a sulfuric acid, a fuming sulfuric acid, a nitric acid, a phosphoric acid, and a combination thereof.
US11634621B2 Organophilic clays and drilling fluids containing them
The organophilic clay comprises a smectite-type clay ion exchanged with quaternary ammonium ions, where at least 75 mol-% of said quaternary ammonium ions are bis-(2-hydroxypropyl)-dimethylammonium fatty acid esters and at least 90% of the fatty acid moieties of the bis-(2-hydroxypropyl)-dimethylammonium fatty acid esters have a structure RC(O) with group R being a linear alkyl or alkenyl group containing from 9 to 21 carbon atoms. The organophilic clay is useful for thickening oil based compositions, in particular drilling fluids for drilling oil or gas wells, comprising an oil phase.
US11634618B2 Abrasive particles, method of making abrasive particles, and abrasive articles
Shaped ceramic abrasive particles include a first surface having a perimeter having a perimeter comprising at least first and second edges. A first region of the perimeter includes the second edge and extends inwardly and terminates at two corners defining first and second acute interior angles. The perimeter has at most four corners that define acute interior angles. A second surface is disposed opposite, and not contacting, the first surface. A peripheral surface is disposed between and connects the first and second surfaces. The peripheral surface has a first predetermined shape. Methods of making the shaped ceramic abrasive particles, and abrasive articles including them are also disclosed.
US11634615B2 Resin composition
A resin composition contains one or more 2-methylene-1,3-dicarbonyl compounds. At least one of the one or more 2-methylene-1,3-dicarbonyl compounds has a molecular weight of 220 to 10,000, and the amount by weight of those of the 2-methylene-1,3-dicarbonyl compounds having a molecular weight of less than 220 relative the entire resin composition of 1 is 0.00 to 0.05. The 2-methylene-1,3-dicarbonyl compounds contain a structural unit represented by formula (I) below.
US11634613B2 Composite cooling film comprising an organic polymeric layer, a UV-absorbing layer, and a reflective metal layer
A composite cooling film including non-fluorinated organic polymeric layer, a metal layer disposed inwardly of the non-fluorinated organic polymeric layer, and an antisoiling, ultraviolet-absorbing hardcoat layer that is disposed outwardly of the non-fluorinated organic polymeric layer.
US11634610B2 Siloxane polymer compositions and their use
The present invention provides a method for covering a substrate, and includes the following operations: (a) admixing at least four different silane monomers and at least one bi-silane to a first solvent(s) to form a mixture, with the proviso that at least one of the silane monomers or the bi-silane comprises an active group capable of achieving cross-linking to adjacent siloxane polymer chains of the siloxane polymer composition; (b) subjecting the mixture to an acid treatment so that the silane monomers are at least partially hydrolysed, and the hydrolysed silane monomers, the silane monomers and the bi-silane are at least partially polymerized and cross-linked; (c) optionally changing the first solvent to a second solvent; and (d) subjecting the mixture to further cross-linking of the siloxane polymer to achieve a predetermined degree of cross-linking, depositing the siloxane polymer composition on the substrate, and optionally curing the deposited siloxane polymer composition.
US11634605B2 Polymeric coating compositions and articles coated with the same
Polymeric coating compositions and articles coated with the polymeric coating compositions are provided. The polymeric coating composition can include an ethylene-based polymer that exhibits desirable melting properties and molecular weight distribution. The polymeric coating composition can provide a thin coating layer on an article while still providing advantageous properties, such as seal strength.
US11634600B2 Ink composition, window using the same, and manufacturing method of window using the same
An ink composition includes an acrylic resin including a polymerization product of a first monomer having a hydroxyl group, a second monomer having an epoxy group, a third monomer having an acrylate group, and a fourth monomer having a substituted or unsubstituted phenyl group, a first curing agent having an isocyanate group, and a second curing agent having an amine group. Durability and abrasion resistance of a window may be improved.
US11634597B2 Method for forming multilayer coating film
A method for forming a multilayer coating film which includes forming an uncured coating film by applying a first aqueous base coating composition, forming an uncured coating film by applying a second aqueous base coating composition, forming an uncured coating film by applying a clear coating composition, and simultaneously heat curing the obtained coating films. The first aqueous base coating composition contains a carbodiimide compound, the clear coating composition contains a hydroxyl group-containing acrylic resin (A) having a hydroxyl value of 120 to 160 mgKOH/g and an acid value of 5 to 10 mgKOH/g, a polyisocyanate compound (B), and a polycarbonate diol compound (C). The component (A) has a hydroxyl group-containing alkyl moiety having 3 or less carbon atoms, and the ratio of the numbers of moles of the isocyanate functional groups of the component (B) and the hydroxyl group functional groups of the component (A) is 1.15 to 1.35.
US11634596B2 Metal powder sintering paste and method of producing the same, and method of producing conductive material
There is a problem that when a silver powder sintering paste that is substantially free from resin is used, an organic solvent used as a dispersion medium bleeds, which results in contamination and wire bonding defects. In order to solve the problem, provided is a metal powder sintering paste that contains, as a principal component, silver particles having an average particle diameter (a median diameter) of 0.3 μm to 5 μm and further contains an anionic surfactant but is substantially free from resin.
US11634595B2 Adhesion promoter for thermoplastic polyolefin substrate
An adhesion promoter for non-conductive surfaces is disclosed that combines a polyolefin with co-resins in a colloidal suspension in water. The colloidal suspension in water is prepared from mixing a solid-powder composition that includes the polyolefin and the co-resins with water. The colloidal suspension in water is applied to a low surface energy, non-conductive substrate, such as thermoplastic olefins, in order to make the substrates conductive for electrostatic painting.
US11634591B2 Sag resistant, formaldehyde-free coated fibrous substrate
The present invention relates to an improved formaldehyde-free coated fibrous substrate. The coating includes a crosslinked binder system which forms three dimensional networks when heat cured. After the coating is applied to the back of fibrous substrate and cured, the coating is capable of hygroscopic expansion which imparts excellent anti-sag properties. The coating is compatible with other coating systems with neutral or mild alkaline pH. The improvement being the binding system is neutralized with a volatile base so that it evaporates quickly so as not to hinder the cross-linking reaction.
US11634584B2 Compositions containing rosin esters
Disclosed are compositions which include an ethylene polymer derived from at least one polar monomer with one or more ester groups, and a rosin ester. The rosin ester can have a low hydroxyl number (e.g., a hydroxyl number seven or less), a low acid number (e.g., an acid number of ten or less), a relatively low PAN number (e.g., a PAN number less than twenty-five), a relatively high third moment or third power average molecular weight (Mz), (e.g., an Mz value in between 2500 and 12000 g/mol), a low sulfur content (e.g., a sulfur content lower than 600 ppm prior to antioxidant addition) or combinations thereof. The compositions can exhibit a high heat stress resistance (e.g., a heat stress pass temperature value higher than 52° C. or in between 48° C. and 60° C.) and/or improved viscosity stability and/or color stability upon thermal aging and/or improved compatibility.
US11634569B2 Composition for odor suppression
A composition for odor control includes (A) from 85 wt % to 99.5 wt % of an olefin-based compound and (B) from 15 wt % to 0.5 wt % of an odor suppressant. The odor suppressant includes a blend of (i) an ionomer, (ii) particles of zinc oxide, and (iii) particles of copper oxide. The composition has a methyl mercaptan odor suppression value of greater than 45% as measured in accordance with ASTM D5504-12.
US11634563B2 Epoxidized natural rubber composite and preparation process thereof
The present disclosure provides an epoxidized natural rubber composite and a preparation process thereof, and relates to the technical field of rubber materials. The epoxidized natural rubber composite provided by the present disclosure comprises the following preparation raw materials in parts by weight: 100 parts of epoxidized natural rubber, 1˜30 parts of peanut meal, 0.05˜0.8 parts of surfactants, 0.1˜4 parts of coagulant and 0.2˜12 parts of vulcanization processing aids. The present disclosure utilizes essential amino acids and non-essential amino acids contained in peanut meal to improve the aging resistance of the epoxidized natural rubber. After hot air aging, ozone aging and ultraviolet aging treatments, both the tensile strength retention rate and the elongation at break retention rate of the epoxidized natural rubber composites of the present disclosure can be kept above 83%.
US11634558B2 Optical resin material for chromatic aberration correction
An optical resin material for chromatic aberration correction is provided including at least 5% by mass of a compound (component A) represented by formula (1) or formula (3), in which R1 to R6 each independently represent a structure represented by formula (2), in which the broken line represents a binding site; n1 represents an integer of 0 to 3; n2 represents an integer of 0 or 1; n3 represents an integer of 0 to 4; R7 represents hydrogen, an acryl group, a methacryl group, a cyanoacryl group, a cyclic ether group, an allyl group, a propargyl group, a hydroxy group, an isocyanate group, chlorine, or an optionally branched alkyl group having 1 to 8 carbon atoms; and X represents an alkylene glycol chain having 2 to 7 carbon atoms or a lactone-modified ketone chain, in which R1 to R6 each independently represent a structure represented by formula (2).
US11634555B2 Colored resin composition, colored film, color filter and liquid crystal display device
A colored resin composition containing an alkali-soluble resin (A), a colorant (B), an organic solvent (C), and a photosensitizer (D), the colored resin composition containing at least a zirconia compound particle as the colorant (B), wherein the zirconia compound particle contains zirconium nitride having a crystallite size of 10 nm or more and 60 nm or less, and the crystallite size is determined from a half width of a peak derived from a (111) plane in an X-ray diffraction spectrum using a CuKα ray as an X-ray source. The present invention provides a highly sensitive colored resin composition by improving light transmissivity in the ultraviolet region (wavelength 365 nm) generally used in photolithography and by improving a light shielding property in the visible region.
US11634551B2 Polymer foam articles and methods of making polymer foams
Molded polymer foam articles are described as having a novel a foam structure. The polymer foam articles include a continuous polymer matrix defining a plurality of pneumatoceles therein which is present throughout the entirety of the article, including in the surface region extending 500 microns beneath the surface of the article. The surface region is further characterized as having compressed pneumatoceles. The novel foam structure is achieved even when molding polymer foam articles comprising a thickness of more than 2 cm, a volume of more than 1000 cm3; or both a volume of more than 1000 cm3 and a thickness of more than 2 cm. Methods of making the molded polymer foam articles are also described.
US11634550B2 Methods of improving lofting agent retention using bicomponent fibers
Methods of forming a lightweight reinforced thermoplastic core layer and articles including the core layer are described. In some examples, the methods use a combination of thermoplastic material, reinforcing fibers and bicomponent fibers to enhance retention of lofting agents in the core layer. The processes permit the use of less material while still providing sufficient lofting capacity in the final formed core layer.
US11634549B2 Method of fabricating patterned cellulose nanocrystal composite nanofibers and nano thin films and their applications
The present invention provides a method for fabricating patterned cellulose nanocrystal (CNC) composite nanofibers and thin films for optical and electromagnetic sensor and actuator application, comprising the following steps of: selecting materials for fabricating patterned cellulose nanocrystal (CNC) composite nanofibers; and fabricating patterned CNCs composite nanofibers by incorporating secondary phases either during electrospinning or post-processing, wherein the secondary phases may include dielectrics, electrically or magnetically activated nanoparticles or polymers and biological cells mechanically reinforced by CNCs.
US11634544B2 Photoaligning materials
The present invention relates to siloxane polymer, copolymer or oligomer for the photoalignment of liquid crystals, especially for the planar orientation of liquid crystals, and which derives from at least one monomer of formula (I), to compositions thereof, to a process for the preparation of the linear, branched or crosslinked siloxane polymer, and to its use for optical and electro optical devices, such as liquid crystal devices (LCDs):
US11634543B2 Polyimide polymer, polyimide mixture and polyimide film
The present disclosure provides a polyimide polymer, which includes a repeating unit represented by formula (I). Formula (I) is defined as in the specification. The present disclosure further provides a polyimide mixture and a polyimide film, wherein the polyimide mixture is prepared by the polyimide polymer, and the polyimide film is prepared by the polyimide mixture.
US11634542B2 High temperature semicrystalline poly(aryl ether ketone) copolymers
Compositions and methods for a semicrystalline poly(aryl ether ketone) copolymers incorporating 2-benzimidazolinone and 4,4′-biphenol as comonomer units with 4,4′-dihalobenzophenone, and compositions and methods for semicrystalline poly(aryl ether ketone) copolymers incorporating 2-benzimidazolinone and 4,4′-biphenol as comonomer units with 1,4-bis(4-dihalobenzoyl)benzene are described herein. The Copolymers have advantageous properties, particularly in terms of high glass transition temperatures (Tg), high melting temperatures (Tm), crystallinity and chemical resistance. The copolymers are suitable for manufacturing high temperature and chemical resistance molded systems and other articles of manufacture via injection molding, extrusion, compression molding, coating, and additive manufacturing.
US11634539B2 Polycarbonate block copolymers and methods thereof
The present disclosure relates to block copolymers comprising, and methods of making thereof, a polycarbonate chain linked to a hydrophilic polymer. Such block copolymers may have the formula B-A-B, where A is a polycarbonate or polyethercarbonate chain and B is a polyether. Provided methods are useful in reducing the amount of waste generated from the synthesis of polycarbonates and provide improved thermal stability and high primary hydroxyl content. Provided block copolymers also have utility as additives in enhanced oil recovery methods, and foam polymer applications.
US11634537B2 Polymerizable composition for optical articles and optical articles made therefrom
The present invention is directed to a polymerizable composition comprising (A) a reaction product of: (a) diethyleneglycol bischloroformate, ethyleneglycol bischloroformate, or combinations thereof; (b) allyl alcohol; (c) optionally, a cyclic polyol selected from the group consisting of a cycloaliphatic polyol having at least one secondary hydroxyl group, a heterocyclic polyol having primary and/or secondary hydroxyl groups, and mixtures thereof; and (d) optionally, at least one linear or branched aliphatic polyol having two to six hydroxyl groups; and (B) an organic peroxide comprising at least three peroxide groups. A polymerizate and/or an optical article comprising the polymerizable compositions of the invention are also provided.
US11634532B2 2-part reactive urethane resin composition and method for producing thereof
Provided is a material having an excellent sound-absorbing performance which can be easily applied to the desired area at the operation site and which can effectively prevent sound leakage.The material includes an open-cell soft polyurethane foam prepared from a 2-part reactive urethane resin composition prepared from a polyisocyanate component and a polyol-containing component, wherein the polyol-containing component comprises a polyol component, catalysts, a foam stabilizer, an amine compound having primary or secondary amino groups, and carbon dioxide; wherein an average sound absorption coefficient of said polyurethane foam is 30% or more, measured in accordance with JIS A 1405-2:2007 for 63 hertz to 5000 hertz; and the length of liquid-dripping is within 300 mm.
US11634531B2 Curable polyfarnesene-based compositions
A polymer having a hydrophobic polymer chain derived from monomers of farnesene and other optional monomers, such as dienes and vinyl aromatics. The polymer also includes one or more terminal functional groups, such as an amino group, a glycidyl group, a carboxylic acid group, a (meth)acrylate group, a silane group, an isocyanate group, an acetoacetate group, a phenolic group, and a hydroxyl group. Functional groups, such as carboxylic acids, may also be grafted along the hydrophobic polymer chain. The polymer may be incorporated in curable compositions that optionally include one or more polymer resins having similar functional groups. Methods for preparing the curable polymer compositions are also provided. The curable or cured form of the polymer composition may be used in various products, such as a sealant, a coating, a caulk, an electric potting compound, a membrane, a sponge, a foam, an adhesive, or a propellant binder.
US11634527B2 Method of preparing vinyl cyanide compound-conjugated diene compound-aromatic vinyl compound graft copolymer, and thermoplastic resin composition including graft copolymer
A method of preparing a graft copolymer includes a step of performing coagulation by adding an acid coagulant to 100 parts by weight (based on solids) of graft copolymer latex prepared by graft-polymerizing an aromatic vinyl compound and a vinyl cyanide compound onto conjugated diene rubber latex; and a step of performing coagulation once more by adding a salt coagulant thereto. In a resulting graft copolymer, coagulation efficiency may be improved and the gloss of the prepared graft copolymer may be increased. In addition, since a b-value measured using a Hunter lab colorimeter and a b-value measured after being left at 250° C. for 15 minutes are low, the graft copolymer may have excellent color characteristics. In addition, since heating loss is low and scorch time is long, the graft copolymer may have excellent processing characteristics.
US11634526B2 Rubber-containing graft polymer, resin composition containing rubber-containing graft polymer, and shaped article of same
Provided is a rubber-containing graft polymer capable of reducing wet heat aging of a shaped article while improving the strength developing property of a thermoplastic resin. In the rubber-containing graft polymer of the present invention, a content of components having a weight-average molecular weight of 800,000 or more is 1% by mass or more with respect to an organic solvent-soluble fraction (100% by mass) of the rubber-containing graft polymer, and a phosphorus content in the rubber-containing graft polymer is 3 to 30 mmol/kg.
US11634524B2 Acid-catalyzed curable coating compositions containing 1,1 di-activated vinyl compounds and related coatings and processes
Acid-catalyzed curable coating compositions containing 1,1-di-activated vinyl compounds are described, including multi-layer coatings. Also provided are processes for coating substrates with coating compositions comprising 1,1-di-activated vinyl compounds. Also provided are coated articles comprising coatings formed from coating compositions comprising 1,1-di-activated vinyl compounds.
US11634523B2 (Meth)acrylic acid alkyl ester polymer and use thereof
Provided are a novel acrylic polymer that has moderate crosslinking reactivity and is suitable for sealant applications and a sealant using the polymer. The (meth)acrylic acid alkyl ester polymer according to the invention has a weight average molecular weight (Mw) measured by gel permeation chromatography (GPC) method of 30,000 to 150,000 and a number average molecular weight (Mn) of less than 20,000 and has 1.1 to 3.0 methyldimethoxysilyl groups, more than 0.5 methyldimethoxysilyl groups at side chains of a molecular chain, and more than 0.5 methyldimethoxysilyl groups at molecular chain terminals, per one molecule of the polymer.
US11634518B2 Resin composition and article made therefrom
A resin composition includes 100 parts by weight of a polyolefin and 20 parts by weight to 150 parts by weight of a homopolymer of Formula (1). The resin composition is useful for making different articles, including a prepreg, a resin film, a laminate or a printed circuit board, which may achieve excellent multi-layer board thermal resistance and thermal resistance after moisture absorption and achieve high glass transition temperature, low dissipation factor, and low Z-axis ratio of thermal expansion.
US11634516B2 Process for producing aqueous polyacrylamide solutions
Process for producing aqueous polyacrylamide solutions by polymerizing an aqueous solution comprising at least acrylamide thereby obtaining an aqueous polyacrylamide gel and dissolving said aqueous polyacrylamide gel in water, wherein the manufacturing steps are allocated to two different locations A and B and the process comprises the step of transporting an aqueous polyacrylamide gel hold in a transportable polymerization unit from a location A to a location B. Modular, relocatable plant for manufacturing aqueous polyacrylamide solutions wherein the units of the plant are located at two different locations A and B.
US11634503B2 Antibody drug conjugates (ADC) that bind to 158P1D7 proteins
Antibody drug conjugates (ADC's) that bind to 158P1D7 protein and variants thereof are described herein. 158P1D7 exhibits tissue specific expression in normal adult tissue, and is aberrantly expressed in glioblastoma, lung cancer, bladder cancer, and breast cancer. Consequently, the ADC's of the invention provide a therapeutic composition for the treatment of cancer.
US11634500B2 Anti-CD73 antibodies and compositions
This invention relates to anti-CD73 antibodies and methods of using them in treating diseases and conditions related to CD73 activity, e.g., cancer.
US11634499B2 Control of trace metals during production of anti-CD38 antibodies
The disclosure relates to methods to control trace metals during production of anti-CD38 antibodies, drug substances and drug products generated using the methods, and uses of the generated drug substances and drug products.
US11634496B2 C-MET agonistic antibody and use thereof
A method for treating or preventing vascular endothelial cell injured diseases, especially cerebral infarctions or myocardial infarctions, by administering a c-MET agonist antibody to a subject in need thereof, and specific c-MET agonist antibodies.
US11634493B2 Tumor immunotherapy target and application thereof
The present invention provides a tumor immunotherapy target and use thereof, specifically provides use of the LSECtin expressed by infiltrating tumor-associated macrophage and BTN3A3 expressed by tumor solely or in combination as a target in tumor immunotherapy, and further provides a substance capable of inhibiting the activity of LSECtin expressed by infiltrating tumor-associated macrophage, the activity of BTN3A3 expressed by tumor, or the interaction of the LSECtin with BTN3A3, including RNA molecules, fusion protein BTN3A3-Ig, and monoclonal antibody 5E08, which can be used as an active ingredient to prepare a tumor immunotherapy drug, and is suitable for industrial applications.
US11634487B2 Diagnostic method
The present invention relates to the field of production, identification and selection of biological binding molecules such as antibodies or fragments thereof, as well as to diagnostic procedures using them in the diagnosis of cancers, in particular malignant B-cell neoplasia. The binding molecules are able to selectively bind to autonomously active or autonomously activated B-cell receptors, the autonomously active or autonomously activated B-cell receptors being characterized by the presence of structural domains to which the binding molecule selectively binds and which are responsible for the autonomously active or autonomously activated state of the B-cell receptors.
US11634486B2 Anti-SEZ6L2 antibodies and antibody drug conjugates
Disclosed herein are anti-Seizure Related 6 Homolog Like 2 (SEZ6L2) antibodies and antibody drug conjugates (ADCs), including compositions and methods of using said antibodies and ADCs.
US11634482B2 Monoclonal antibodies to growth and differentiation factor 15 (GDF-15), and uses thereof for treating cancer cachexia and cancer
The present invention relates to monoclonal anti-human-GDF-15 antibodies. The antibodies include chimeric anti-bodies and humanized antibodies. The invention also relates to monoclonal anti-human-GDF-15 antibodies including murine anti-bodies, chimeric antibodies and humanized antibodies for use in methods for the treatment of cancer cachexia and also for the treatment of cancer. The invention also provides pharmaceutical compositions, kits, methods and uses and cell lines capable of producing the monoclonal antibodies of the invention.
US11634480B2 Human antibodies to GREM1
The present invention provides antibodies that bind to human gremlin-1 (GREM1), and methods of use. According to certain embodiments of the invention, the antibodies are fully human antibodies that bind to GREM1. The antibodies of the invention are useful for inhibiting or neutralizing GREM1 activity, thus providing a means of treating a GREM1-related disease or disorder such as fibrosis and cancer. In some embodiments, the antibodies of the present invention are used in treating at least one symptom or complication of fibrosis of the liver, lungs or kidney.
US11634477B2 Neutralizing anti-SARS-CoV-2 antibodies and methods of use thereof
This disclosure provides novel broadly neutralizing anti-SARS-CoV-2 antibodies or antigen-binding fragments thereof. The disclosed anti-SARS-CoV-2 antibodies constitute a novel therapeutic strategy in protection from SARS-CoV-2 infections.
US11634476B2 Mammalian cell culture
The invention provides a method for culturing mammalian cells. The method provides greater control over cell growth to achieve high product titer cell cultures.
US11634472B2 Treatment of monogenetic disorders
The present invention relates to a nucleic acid expression cassette, in particular for the expression of a human liver-specific and/or liver-expressed protein and/or preferably physiologically active domains and/or fragments thereof in a patient suffering from a monogenetic disorder caused by a mutation in the gene coding for the liver-specific and/or liver-expressed protein.
US11634471B2 Transduced T cells expressing human SSTR2 and application thereof
The present invention is directed to transduced T cells expressing at least 100,000 molecules of human somatostatin receptor 2 (SSTR2), which improves PET/CT imaging sensitivity. The present invention is also directed to transduced T cells expressing SSTR2 and chimeric antigen receptor (CAR). In one embodiment, the CAR is specific to human ICAM-1 and the CAR comprises a binding domain that is scFv of anti-human ICAM-1, or an I domain of the αL subunit of human lymphocyte function-associated antigen-1. In another embodiment, the CAR is specific to human CD19, and the CAR comprises a binding domain that is scFv of anti-human CD19. The present invention is further directed to using the above transduced T cells for monitoring T cell distribution in a patient by PET/CT imaging and/or treating cancer.
US11634468B2 Parathyroid hormone variants
The invention relates to parathyroid hormone (PTH) variants and pharmaceutical compositions comprising same. The invention further relates to PTH compositions with improved serum half-life and peak-trough ratios, and methods of controlling serum calcium levels with the PTH variants and compositions of the invention. The invention further relates to methods of treating hypoparathyroidism and/or hypocalcemia due to hypoparathyroidism with the PTH variants and compositions of the invention.
US11634467B2 Cytokine-based bioactivatable drugs and methods of uses thereof
The present disclosure provides a cytokine-based bioactivatable drug construct (“VitoKine”) platform that aims to reduce systemic mechanism-based toxicities and lead to broader therapeutic utility for proteins and cytokines such as IL-15 and IL-2 for the treatment of cancer, autoimmune diseases, inflammatory diseases, viral infection, transplantation and various other disorders. The novel VitoKine constructs of the present invention comprise: 1) a tissue or disease site targeting moiety D1 domain (“D1”), 2) a bioactivatable moiety D2 domain (“D2”), and a concealing moiety D3 domain (“D3”). Importantly, because the “active moiety” of the VitoKine construct will remain inert until activated locally by proteases that are upregulated in diseased tissues, this will limit binding of the active moiety to the receptors or to the targets in the peripheral or on the cell-surface of non-diseased cells and tissue to prevent over-activation of the pathway and reduce undesirable “on-target” “off tissue” toxicities. Additionally, the inertness of the VitoKine active moiety prior to protease activation will significantly decrease the potential antigen or target sink, and thus, prolong the in vivo half-life and result in improved biodistribution, bioavailability and therapeutic efficacy.
US11634465B2 Analogues of VDAC1-derived peptides
The present invention relates to peptides comprising analogues of VDAC1-derived peptides having improved pharmacokinetic characteristics compared to the native parent peptides, which are effective in impairing cell energy production, in inducing apoptosis and cell death, particularly of cancerous cells, in eliminating cancer stem cells and in reducing symptoms associated with fat accumulation in liver cells particularly with nonalcoholic fatty liver disease (NAFLD) and symptoms associated thereto.
US11634464B2 Recombinant polypeptides derived from FBP1 and FBP2 and uses of the same
Disclosed herein are recombinant polypeptides derived from FBP1 and FBP2. Also disclosed herein are recombinant expression vectors and recombinant host cells for producing the aforesaid recombinant polypeptides. The recombinant polypeptides are proven to be useful and effective in producing a picornavirus with a type I internal ribosome entry site (IRES), so as to facilitate the preparation of a viral vaccine.
US11634462B2 Methods of processing ß-lactoglobulin-containing compositions with thermolysin and transglutaminase
Methods of processing protein, methods of generating products with the processed protein, and products comprising and/or made with the processed protein. The methods of processing protein include hydrolyzing the protein with a proteolytic agent such as thermolysin to generate hydrolyzed peptides and, optionally, crosslinking the hydrolyzed peptides with a transglutaminase to generate crosslinked peptides. The methods reduce the allergenicity of allergenicity proteins such as β-lactoglobulin and casein. The methods of generating products with the processed protein include methods of making foams, emulsions, and/or food products with the processed protein. The products comprising and/or made with the processed protein accordingly include foams, emulsions, and food products. The foams, emulsions, and food products have decreased allergenicity compared to corresponding products made with non-processed proteins.
US11634460B2 Non-neuronal snare-cleaving botulinum neurotoxins
The present invention provides a modified botulinum neurotoxin A (BoNT/A) L-chain protease that demonstrates enhanced cleaveage of human SNAP-23 (hSNAP-23) relative to unmodified (wild-type) BoNT/A L-chain protease, together with the use thereof for cleaving hSNAP-23.
US11634455B2 Amino diacids containing peptide modifiers
The present invention relates to peptide modifier compounds of Formula (1), or a salt thereof, wherein: a is an integer from 1 to 10, more preferably from 1 to 3; b is an integer from 0 to 7; Z is a terminal group and Y is a bivalent group. Further aspects of the invention relate to intermediates in the preparation of compounds of Formula (1), and the use of compounds of Formula 1 in the synthesis of peptide derivatives.
US11634453B2 Neuroactive steroids substituted in position 10 with a cyclic group for use in the treatment of CNS disorders
Provided herein is a compound of Formula (I) or a pharmaceutically acceptable salt thereof, wherein n, R19, R5, R3a, R6a, R6b, R1, R2a, R2b, R4a, R4b, R7a, R7b, R11a, R11b, R12a, R12b, R17b, R15a, R15b, R16a and R16b are defined herein. Also provided herein are pharmaceutical compositions comprising a compound of Formula (I) and methods of using the compounds, e.g., in the treatment of CNS-related disorders.
US11634451B2 Method for the site-specific enzymatic labelling of nucleic acids in vitro by incorporation of unnatural nucleotides
Provided herein are analogs of unnatural nucleotides bearing predominantly hydrophobic nucleobase analogs that form unnatural base pairs during DNA polymerase-mediated replication of DNA or RNA polymerase-mediated transcription of RNA. In this manner, the unnatural nucleobases can be introduced in a site-specific way into oligonucleotides (single or double stranded DNA or RNA), where they can provide for site-specific cleavage, or can provide a reactive linker than can undergo functionalization with a cargo-bearing reagent by means of reaction with a primary amino group or by means of click chemistry with an alkyne group of the unnatural nucleobase linker.
US11634447B2 Mannose derivatives for treating bacterial infections
The present invention relates to compounds useful for the treatment or prevention of bacteria infections. These compounds have formula I: The invention also provides pharmaceutically acceptable compositions containing the compounds and methods of using the compositions in the treatment of bacteria infections. Finally, the invention provides processes for making compounds of the invention.
US11634442B2 Methods for the purification of L-glufosinate
Compositions and methods for isolating L-glufosinate from a composition comprising L-glufosinate and glutamate are provided. The method comprises converting the glutamate to pyroglutamate followed by the isolation of L-glufosinate from the pyroglutamate and other components of the composition to obtain substantially purified L-glufosinate. The composition comprising L-glufosinate and glutamate is subjected to an elevated temperature for a sufficient time to allow for the conversion of glutamate to pyroglutamate, followed by the isolation of L-glufosinate from the pyroglutamate and other components of the composition to obtain substantially purified L-glufosinate. The glutamate alternatively may be converted to pyroglutamate by enzymatic conversion. The purified L-glufosinate is present in a final composition at a concentration of 90% or greater of the sum of L-glufosinate, glutamate, and pyroglutamate. In some embodiments, a portion of the glutamate in the starting composition may be separated from the L-glufosinate using a crystallization step. Solid forms of L-glufosinate materials, including crystalline L-glufosinate ammonium, are also described.
US11634440B2 Method of forming a crystalline or polycrystalline layer of an organic-inorganic metal halide perovskite
The present invention provides a method of forming a crystalline or polycrystalline layer of an organic-inorganic metal halide perovskite material comprising a three-dimensional crystal structure represented by the formula AMX3, in which A represents an organic cation or a mixture of two or more different cations, at least one of which is an organic cation, M represents a divalent metal cation or a mixture of two or more different divalent metal cations, and X represents halide anions which are the same or different, the method comprising the steps of: (i) forming a first layer on the surface of a substrate, the first layer comprising an organic-inorganic metal halide perovskite material having a planar, layered two-dimensional crystal structure (ii) reacting the first layer with one or more organic halides to form the crystalline or polycrystalline layer comprising an organic-inorganic metal halide perovskite material having the formula AMX3. Also provided is an optoelectronic or photovoltaic device including an active layer comprising an organic-inorganic metal halide perovskite material comprising a three-dimensional crystal structure represented by the formula AMX3, wherein the material is obtainable using the above defined method.
US11634439B2 Organosilicon compound having cyclic silazane structure, composition containing the same, and method for producing the same
To provide an organosilicon compound having a cyclic silazane structure, represented by the following general formula (1): wherein R1 represents a hydrogen atom, an oxy radical, a hydroxyl group, a substituted or unsubstituted alkoxy group having 1 to 10 carbon atoms, or a substituted or unsubstituted monovalent hydrocarbon group having 1 to 10 carbon atoms, R2 represents a substituted or unsubstituted alkylene group having 3 to 6 carbon atoms, R3 and R each independently represent a substituted or unsubstituted monovalent hydrocarbon group having 1 to 10 carbon atoms, and n represents an integer of 0 to 2.
US11634431B2 Process for purification of protected polycyclic carbamoylpyridone derivatives
The present invention relates to a process for purification of protected polycyclic carbamoylpyridone derivatives and its conversion to polycyclic carbamoylpyridone derivatives or its pharmaceutically acceptable salts thereof.
US11634430B2 Heterocyclic compound and organic light emitting element comprising same
The present specification provides a heterocyclic compound of Chemical Formula 1, and an organic light emitting device comprising the same. The heterocyclic compound used as a material of an organic material layer of an organic light emitting device provides enhanced efficiency, low driving voltage, and enhanced lifetime properties of the organic light emitting device.
US11634426B2 Selective estrogen receptor degraders
Novel selective estrogen receptor degraders (SERDs) according to the formula: pharmaceutically acceptable salts thereof, and pharmaceutical compositions thereof, wherein either R1 or R2 is independently selected from Cl, F, —CF3, or —CH3, and the other is hydrogen, and methods for their use are provided.
US11634423B2 Substituted pyrazolo[1,5-a]pyrimidines as inhibitors of interferon signaling
The present invention provides a compound of Formula I: wherein R is or a pharmaceutically acceptable salt thereof, useful for treating psoriasis, systemic lupus erythematosus, or type 1 diabetes.
US11634422B2 Inhibitors of activin receptor-like kinase
Described herein are compounds that inhibit ALK2 and its mutants, pharmaceutical compositions including such compounds, and methods of using such compounds and compositions.
US11634418B2 Amino acid compounds and methods of use
The invention relates to compounds of formula (I): or a salt thereof, wherein R1, R5, R7, R8, X, m, n, p and q are as described herein. Compounds of formula (I) and pharmaceutical compositions thereof are αvβ6 integrin inhibitors that are useful for treating tissue specific fibrosis such as idiopathic pulmonary fibrosis (IPF) and nonspecific interstitial pneumonia (NSIP).
US11634415B2 Derivatives of substituted morpholines and uses thereof
A compound of Formula I includes a stereoisomer thereof and/or a salt thereof; wherein R1 is a substituted alkane group, a heterocylic group, or a pyridine group; X is hydrogen, a halogen, an amino acid residue, a substituted amino acid residue, an alkyl group, or an ester. Such compounds may be used in pharmaceutical compositions and for the treatment of central nervous system (CNS) disorders:
US11634410B2 Substituted 3-azabicyclo[3.1.0]hexanes as ketohexokinase inhibitors
Provided herein are substituted 3-azabicyclo[3.1.0]hexanes as ketohexokinase inhibitors, processes to make said compounds, and methods comprising administering said compounds to a mammal in need thereof.
US11634408B2 Aryl hydrocarbon receptor modulators and uses thereof
Provided are compounds of Formula (I), and pharmaceutically acceptable salts, solvates, hydrates, stereoisomers, tautomers, isotopically labeled derivatives, polymorphs, and prodrugs thereof, wherein X1-X4, RX, RC, RB, n, and Ring A are as defined herein. The compounds may be aryl hydrocarbon receptor agonists or partial aryl hydrocarbon receptor agonists. Also provided are pharmaceutical compositions comprising a compound of Formula (I) and methods of using such compounds for treating diseases and conditions related to the activity of an aryl hydrocarbon receptor, such as, for example, inflammatory diseases, autoimmune diseases, metabolic disorders, and proliferative diseases.
US11634407B2 Cereblon binding compounds, compositions thereof, and methods of treatment therewith
Provided herein are piperidine dione compounds having the following structure: wherein RN, R1, R2, R3, R4, RN, L, V, X, a, m, and n are as defined herein, compositions comprising an effective amount of a piperidine dione compound, and methods for treating or preventing an androgen receptor mediated disease.
US11634405B2 Compounds with tubulin polymerisation inhibitory activity and immunomodulatory properties
The present invention relates to the Compound of following formula (I): or a pharmaceutically acceptable salt thereof. The present invention also relates to a pharmaceutical composition containing such a compound and a method for preparing such a compound.
US11634401B2 Process-scale synthesis of urolithin A
Disclosed are methods for preparing a salt of urolithin A and, in turn, urolithin A. The methods are advantageous for the large-scale preparation of urolithin A or a pharmaceutically acceptable salt thereof.
US11634400B2 Micheliolide derivatives, methods for their preparation and their use as anticancer and antiinflammatory agents
The present invention relates to derivatives of the sesquiterpene lactone micheliolide, methods and compositions for their preparation, and methods for using the micheliolide derivatives in pharmaceutical compositions as anticancer and anti-inflammatory agents. The invention also relates to methods for producing micheliolide derivatives modified at positions C2 and C14. The invention also relates to methods for producing parthenolide derivatives modified at positions C2 and C14 in conjunction with modifications at position C13, via chemoenzymatic methods. The invention further relates to methods for using parthenolide derivatives for treating cancer and inflammatory diseases.
US11634396B2 Opioid receptor modulators
Provided herein are opioid receptor modulators and pharmaceutical compositions comprising said compounds.
US11634395B2 Sulfonamide compound or salt thereof
The present invention provides a novel sulfonamide compound having a ribonucleotide reductase inhibitory activity or a salt thereof, and a pharmaceutical composition containing the same as an active ingredient.A compound represented by Formula (I) [wherein, X1 represents an oxygen atom or the like; X2 represents an oxygen atom; X3 represents —NH—; X4 represents a hydrogen atom or the like; R1 represents —C(R11)(R12)— or the like; R11 and R12 are the same or different and each represents a hydrogen atom or the like; R2 represents an optionally substituted C6-C14 aromatic hydrocarbon group or the like; R3 represents an optionally substituted C6-C14 aromatic hydrocarbon group or the like; R4 represents a hydrogen atom or the like] or a salt thereof.
US11634393B2 Substituted tolyl fungicides
Disclosed are compounds of Formula 1, including all geometric and stereoisomers, tautomers, N-oxides, and salts thereof, wherein A, Q, R1, R2, R3, R4, W and Y are as defined in the disclosure. Also disclosed are compositions containing the compounds of Formula 1 and methods for controlling plant disease caused by a fungal pathogen comprising applying an effective amount of a compound or a composition of the invention.
US11634391B2 Compounds which are inhibitors of Notum
A compound for use in the treatment of a disease ameliorated by the inhibition of Notum of formula (I): (I)
US11634386B2 Method for producing diphenylsulfone compound
A diphenylsulfone compound containing 4,4′-dihydroxydiphenylsulfone is produced in good yield in a short time and at a relatively low temperature. A diphenylsulfone compound represented by formula (2) below is produced by irradiating, with microwaves, a compound represented by formula (1) below and a sulfonating agent so that a dehydration condensation reaction is carried out.
US11634384B2 Prodrugs of phenolic TRPV1 agonists
Described herein are compounds, pharmaceutical compositions and medicaments that include such compounds, and methods of using such compounds to modulate transient receptor potential vanilloid 1 receptor (TRPV1) activity.
US11634379B2 Lipids and lipid nanoparticle formulations for delivery of nucleic acids
Compounds are provided having the following structure: or a pharmaceutically acceptable salt, tautomer or stereoisomer thereof, wherein R1a, R1b, R2a, R2b, R3a, R3b, R4a, R4b, R5, R6, R7, R8, R9, L1, L2, a, b, c, d and e are as defined herein. Use of the compounds as a component of lipid nanoparticle formulations for delivery of a therapeutic agent, compositions comprising the compounds and methods for their use and preparation are also provided.
US11634378B2 Compounds and methods targeting GPER in calcium disorders
The present disclosure provides compositions and method targeting GPER for the treatment of cancers, such as breast cancers and leukemias, gallstone disease, and for conferring of neuroprotection on a subject. Also disclosed are high throughput assays for identifying antagonists of GPER.
US11634377B2 Fenfluramine compositions and methods of preparing the same
Methods of preparing a fenfluramine active pharmaceutical ingredient are provided. Aspects of the method include (a) hydrolyzing a 2-(3-(trifluoromethyl)phenyl)acetonitrile composition to produce a 2-(3-(trifluoromethyl)phenyl)acetic acid composition; (b) reacting the 2-(3-(trifluoromethyl)phenyl)acetic acid composition with acetic anhydride and a catalyst to produce a 1-(3-(trifluoromethyl)phenyl)propan-2-one composition; and (c) reductively aminating the 1-(3-(trifluoromethyl)phenyl)propan-2-one composition with ethylamine using a borohydride reducing agent to produce a fenfluramine composition. Also provided are compositions and pharmaceutical ingredients prepared according to the subject methods including a pharmaceutically acceptable salt of fenfluramine and having less than 0.2% by weight in total of trifluoromethyl regioisomers.
US11634371B2 Advanced adsorptive separation processes for molecular class separation
A method for separating classes of hydrocarbon compounds from a feed stream including a hydrocarbon mixture is disclosed. The method includes the steps of passing a feed stream through a plurality of separation units arranged in a series in any order, wherein each separation unit has an adsorbent material; and separating classes of hydrocarbon compounds from the feed stream. When one of the plurality of separation units comprises an adsorbent material that is a metal organic framework selected from a zirconium, hafnium, cerium, or titanium-based metal organic framework, then another plurality of separation units includes an adsorption material that is different from the metal organic framework. The method is conducted in a liquid phase. The method can also use a single separation unit with a continuous cyclic bed apparatus. The method can be combined with refining and downstream processes.
US11634368B2 Agricultural compositions
This document provides compositions comprising (or consisting essentially of or consisting of) one or more water-soluble oils selected from the group consisting of ethoxylated macadamia oil, ethoxylated olive oil, ethoxylated avocado oil, ethoxylated meadowfoam oil, ethoxylated almond oil, ethoxylated corn oil, ethoxylated soybean oil, ethoxylated jojoba oil, ethoxylated seabuckthorn oil (e.g., fruit, berry, or seed oil), ethoxylated emu oil, ethoxylated mink oil, PEG Glyceryl Dimyristate, PEG Glyceryl Dioleate, PEG Glyceryl Distearate, and PEG Glyceryl Palmitate; and one or more agricultural chemical or biological agents. Methods for making and using the compositions also are provided.
US11634365B2 Low temperature carbon/bn/aluminum oxide coating
A method of forming an activated coating composition is disclosed. The method includes providing (a) boron nitride, (b) carbon, (c) aluminum oxide and (d) a liquid carrier. Each of the boron nitride, carbon and aluminum oxide are in particulate form. The coating composition is activated to form an activated coating composition. The activated coating composition includes active components having from about 60.0 wt % to about 90.0 wt % boron nitride, from about 16 wt % to about 24 wt % carbon and from about 4 wt % to about 6 wt % aluminum oxide. A coating method, coated substrate and activated coating composition are also disclosed.
US11634363B2 Refractory object and method of forming
A refractory object may include a zircon body that is intentionally doped with a dopant including an alkaline earth element and aluminum. The refractory object can have an improved creep deformation rate. In an embodiment, the refractory object can have a creep deformation rate of not greater than about 1.8 E-5 h−1 at a temperature of 1350° C. and a stress of 2 MPa. In another embodiment, the zircon body may include an amorphous phase including an alkaline earth metal element.
US11634362B2 Process for the manufacture of a fused block having a high zirconia content
A process for the manufacture of a refractory block including more than 80% zirconia, in percentage by weight based on the oxides. The process includes the following successive stages: melting, under reducing conditions, of a charge including more than 50% zircon, in percentage by weight, such as to reduce the zircon and obtain a molten material, application of oxidizing conditions to the molten material, casting of the molten material, and cooling until at least partial solidification of the molten material in the form of a block. Also, the process can include heat treatment of the block.
US11634358B2 Polycarbonate diol coating composition for caustic and UV resistance
A curable glass coating composition including 5-70 wt % aliphatic polycarbonate diol, 5-60 wt % crosslinker, 1-20 wt % extender, 4-20 wt % fatty alcohol, and 2-30 wt % crystalline or amorphous powder filler material, and optionally 2-20 wt % aliphatic polyester polyol and 2-20 wt % cycloaliphatic epoxy. The coating composition can be applied to a glass substrate and cured to form a decorative cured polyurethane coating layer on the substrate that has improved caustic and UV resistance.
US11634357B2 High strength glass-ceramics having petalite and lithium silicate structures
In embodiments, a precursor glass composition comprises from about 55 wt. % to about 80 wt. % SiO2; from about 2 wt. % to about 20 wt. % Al2O3; from about 5 wt. % to about 20 wt. % Li2O; greater than 0 wt % to about 3 wt. % Na2O; a non-zero amount of P2O5 less than or equal to 4 wt. %; and from about 0.2 wt. % to about 15 wt. % ZrO2. In embodiments, ZrO2 (wt. %)+P2O5 (wt. %) is greater than 3. When the precursor glass composition is converted to a glass-ceramic article, the glass-ceramic article may include grains having a longest dimension of less than 100 nm.
US11634352B2 Method and apparatus for shaping a glass workpiece with minimal lubrication
An apparatus for shaping a workpiece made of glass using minimum lubrication is provided. The apparatus includes device for heating the workpiece, a shaping station with at least one forming tool for shaping the workpiece, and at least one spray nozzle for applying an oil as a lubricant onto the surface of the forming tool. The forming tool exhibits heat dissipation such that the temperature on the contact surface of the forming tool during the shaping process is kept below 300° C. The amount of oil dispensed by the spray nozzle per forming step and application instance is less than 0.1 g.
US11634340B2 Layered group III-V compound and nanosheet containing arsenic, and electrical device using the same
Proposed are a layered Group III-V arsenic compound, a Group III-V nanosheet that may be prepared using the same, and an electrical device including the materials. There is proposed a layered compound having a composition represented by [Formula 1] Mx-mAyAsz (Where M is at least one of Group I elements, A is at least one of Group III elements, x, y, and z are positive numbers which are determined according to stoichiometric ratios to ensure charge balance when m is 0, and 0
US11634335B2 Iron-loaded small pore aluminosilicate zeolites and method of making metal loaded small pore aluminosilicate zeolites
The present invention provides an iron-loaded aluminosilicate zeolite having a maximum pore opening defined by eight tetrahedral atoms and having the framework type CHA, AEI, AFX, ERI or LTA, wherein the iron (Fe) is present in a range of from about 0.5 to about 5.0 wt. % based on the total weight of the iron-loaded aluminosilicate zeolite, wherein an ultraviolet-visible absorbance spectrum of the iron-loaded synthetic aluminosilicate zeolite comprises a band at approximately 280 nm, wherein a ratio of an integral, peak-fitted ultraviolet-visible absorbance signal measured in arbitrary units (a.u.) for the band at approximately 280 nm to an integral peak-fitted ultraviolet-visible absorbance signal measured in arbitrary units (a.u.) for a band at approximately 340 nm is >about 2. The present invention further provides a method of making an metal-loaded aluminosilicate zeolite having a maximum pore opening defined by eight tetrahedral atoms from pre-existing aluminosilicate zeolite crystallites, wherein the metal is present in a range of from 0.5 to 5.0 wt. % based on the total weight of the metal-loaded aluminosilicate zeolite.
US11634334B2 Method of synthesizing an aluminosilicate molecular sieve by a crystal seed-assisted method
The present disclosure provides a method of synthesizing an aluminosilicate molecular sieve by a crystal seed-assisted method, a natural aluminosilicate clay mineral treated and activated by an alkali is used as a crystal seed for synthesis of the aluminosilicate molecular sieve, and the target molecular sieve product is synthesized by hydrothermal crystallization, wherein the synthesis process does not require addition of conventional crystal seeds of a molecular sieve or use of any organic template agent, thus the synthesized product does not require a calcination process to remove the template agent. The method of synthesizing an aluminosilicate molecular sieve by a crystal seed-assisted method can meet the requirements of both crystallinity and nucleation time, and greatly reduce costs of synthesizing the aluminosilicate molecular sieve, and reduce the environmental pollution caused by removal of the template agent by calcinating.
US11634329B2 Liquid-exfoliated nanomaterials
Nanoplatelets are prepared from a 3D layered material by: providing a dispersion of the 3D layered material, pressurising the dispersion, rapidly depressurising the dispersion to create shear forces that exfoliate the 3D layered material into nanoplatelets; and/or providing a dispersion of the 3D layered material, forming a first flow of the dispersion along a first flowpath in a first direction, forming a second flow of the dispersion along a second flowpath in a second direction by reversing the first flow or by forming the second flow in a second flowpath, wherein the second flowpath is substantially reverse and non-coaxial with the first flowpath, whereby shear forces between material in the first flowpath and material in the second flowpath exfoliate the 3D layered material into nanoplatelets. Also provided are apparatuses for carrying out the invention and nanoplatelets obtained by the invention.
US11634325B2 Absorber column and process for cleaning crude synthesis gas
The invention relates to an absorber column and to the use thereof for separation of unwanted, especially acidic, gas constituents, for example carbon dioxide and hydrogen sulfide, from a crude synthesis gas by absorption with an absorbent, especially under low load states of the absorber column in relation to the synthesis gas velocity. According to the invention, a defined concentration of carbon dioxide in the clean synthesis gas is established by mixing at least a portion of the absorbent regenerated by flash regeneration with the absorbent regenerated by means of hot regeneration prior to the recycling thereof into the absorber column.
US11634324B2 Systems and methods for processing gases
The invention includes a gas processing system for transforming a hydrocarbon-containing inflow gas into outflow gas products, where the system includes a gas delivery subsystem, a plasma reaction chamber, and a microwave subsystem, with the gas delivery subsystem in fluid communication with the plasma reaction chamber, so that the gas delivery subsystem directs the hydrocarbon-containing inflow gas into the plasma reaction chamber, and the microwave subsystem directs microwave energy into the plasma reaction chamber to energize the hydrocarbon-containing inflow gas, thereby forming a plasma in the plasma reaction chamber, which plasma effects the transformation of a hydrocarbon in the hydrocarbon-containing inflow gas into the outflow gas products, which comprise acetylene and hydrogen. The invention also includes methods for the use of the gas processing system.
US11634320B2 Micro-electromechanical system device including a precision proof mass element and methods for forming the same
A semiconductor oxide plate is formed on a recessed surface in a semiconductor matrix material layer. Comb structures are formed in the semiconductor matrix material layer. The comb structures include a pair of inner comb structures spaced apart by a first semiconductor portion. A second semiconductor portion that laterally surrounds the first semiconductor portion is removed selective to the comb structures using an isotropic etch process. The first semiconductor portion is protected from an etchant of the isotropic etch process by the semiconductor oxide plate, the pair of inner comb structures, and a patterned etch mask layer that covers the comb structures. A movable structure for a MEMS device is formed, which includes a combination of the first portion of the semiconductor matrix material layer and the pair of inner comb structures.
US11634318B2 MEMs using outgassing material to adjust the pressure level in a cavity
The present disclosure provides a micro electro mechanical system (MEMS) structure, including a device substrate having a first region and a second region different from the first region, a capping substrate bonded over the device substrate, a first cavity in the first region and between the device substrate and capping substrate, wherein the first cavity has a first cavity pressure, a second cavity in the second region and between the device substrate and capping substrate, wherein the second cavity has a second cavity pressure lower than the first cavity pressure, a passivation layer in the first cavity, an outgassing material over the passivation layer, wherein the outgassing material comprises a top surface and a sidewall exposed to the first cavity.
US11634309B2 Multi-tool container opening device
A container opening device is provided. The device can comprise a plurality of opening structures, including at least a pry portion, a twist-off portion, and a finger receiving portion. A gripping portion can also be included. These structures and elements define a multi-tool device configured to open various types of containers, such as beverage bottles having a pop-off cap, beverage bottles having a twist-off cap, and beverage cans having an opening tab (e.g., pull tab).
US11634302B2 Elevator belt monitoring apparatus and blade contact
An elevator belt monitoring apparatus includes a housing for receiving an elevator belt and a plurality of blade contacts which are operable to pierce the belt and engage the spaced parallel cords arranged within the belt. A plurality of bridge contacts are connected with adjacent pairs of elevator belt cords and signal contacts are connected with cords at the outer edges of the belts. The signal contacts are connected with a monitoring device which sends and receives signals to the contacts to provide an indication of the condition or deterioration of the belt.
US11634301B2 System and method for detection of a malfunction in an elevator
A system and method for detection of a malfunction in an elevator. The system includes an elevator cab, a server, at least one sensor, and a controller. The controller receives a signal captured by the at least sensor and transmit to the server. The server processes the transmitted signal and prognostically detects the malfunction in the elevator cab.
US11634300B2 Method for detecting an entry into an elevator car of an elevator system by a passenger
A method for detecting an entry into an elevator car of an elevator system by a passenger uses a mobile device carried by the passenger. The mobile device has at least one, but in particular a plurality of sensors, with which the mobile device detects and evaluates measured values. An entry into the elevator car is then detected on the basis of comparing the measured values with at least one stored signal pattern.
US11634297B2 Media folding device and control method for media folding device
A media folding device includes a stacking portion on which media transported from an introduction path are placed; a folding roller pair that folds the media at a folding position after the media have been stacked in the stacking portion; and a bend forming mechanism that includes a first abutting portion configured to abut against a front end of the media, which are stacked in the stacking portion, in a transport direction, and a second abutting portion that is configured to abut against a rear end of the media, which are stacked in the stacking portion, in the transport direction, and that causes the folding position of the media to be nipped by the folding roller pair the folding roller pair by shortening the relative distance between the first abutting portion and the second abutting portion to bend the media toward the folding roller pair.
US11634296B2 Method and apparatus for correcting a feeding distance of a strip for cutting
A method and an apparatus for correcting a feeding distance of a strip or cutting, involves feeding the strip over the feeding distance in a feeding direction towards a cutting line that extends at an oblique cutting angle to the feeding direction; detecting a lateral position of a first longitudinal edge of the strip in a lateral direction perpendicular to the feeding direction; wherein, when the detected lateral position is offset over an offset distance in the lateral direction with respect to a reference position for the first longitudinal edge at the measuring line, and adjusting the feeding distance with a correction distance that is related to the offset distance in a ratio that is defined by the cutting angle.
US11634288B2 Tray swinging mechanism and device including the same
According to aspects of the present disclosure, there is provided a tray swinging mechanism including a document tray. A movable plate of the document tray is configured to be swingable about a tray shaft and extends leftward. A lifter is configured to be swingable about a lifter shaft extending in the front-rear direction at a position different from the tray shaft. On a lower surface of the movable plate, a cam surface configured to contact a tip of the lifter is formed. The cam surface includes a parallel part parallel to an upper surface of the movable plate and a curved part spaced from the upper surface farther toward a right side. According to a shape of the cam surface, each time the lifter is rotated by a particular angle, the tip of the movable plate moves by a particular amount.
US11634284B1 Dry brush conveyor belt cleaning device and system
A cleaning device and system operable to a continuous conveyor is shown. The cleaning assembly is operable to clean debris from the continuous conveyer. The cleaning device comprises a cleaning assembly mounted below a lower conveyor belt. The cleaning assembly is pivotable to form an angle with respect to a direction of the lower conveyor run. The cleaning assembly has a removable cartridge having a shaft with a pair of ends and having a cylindrical cleaner mounted on said shaft.
US11634282B2 Systems and methods for processing objects, including automated processing stations
A processing system for processing objects using a programmable motion device is disclosed. The processing system a perception unit for perceiving identifying indicia representative of an identity of an object associated with an input conveyance system, and an acquisition system for acquiring the object from a plurality of objects at an input area using an end effector of the programmable motion device, wherein the programmable motion device is adapted for assisting in the delivery of the object to an identified processing location. The identified processing location being associated with the identifying indicia and said identified processing location being provided as one of a plurality of processing locations. The processing system also includes a delivery system for receiving the object in a carrier and for delivering the object toward the identified processing location.
US11634281B2 Temporary storage shelf board, goods shelf, control method and device, apparatus and system
A temporary storage shelf board, a goods shelf, a control method, an apparatus and a system are provided. The temporary storage shelf board is used for providing multiple temporary storage positions. The temporary storage shelf board is provided with fork pockets, and the fork pockets is used for cooperating with a fork arm of a first robot. A goods storage and retrieval channel of the first robot is formed below the temporary storage shelf board, and when goods are stored and retrieved, the first robot is located at the goods storage and retrieval channel, and the fork pockets cooperate with the fork arm on the first robot to store and retrieve the goods. Thus, the efficiency of goods storage and retrieval can be improved.
US11634276B2 Trash can
A trash can that includes a frame, a liner, a lid, and a bag cover. The frame has a base and a casing supported on the base. The liner is removably disposed within a cavity of the casing. The lid is coupled to and rotatable relative to the frame between a closed position, in which the liner is concealed, and an open position, in which the liner is accessible. The bag cover is coupled to the frame and rotatable relative to the frame and the lid between a closed position, in which a top of the liner is concealed and the bag cover prevents the liner from being removed from the casing, and an open position, in which the top of the liner is accessible and the liner is removable from the cavity of the casing.
US11634275B2 Coupler with quick release handle and valve assemblies
A fluid coupling includes a body, a poppet valve assembly, a handle shaft assembly, and a retention member. The body has a fluid conduit, a through-hole extending through a sidewall, and one or more openings that extend between an external surface of the body and an interior of the through hole. The poppet valve assembly is disposed within the fluid conduit and is selectively movable between an open position and a closed position. The handle shaft assembly extends through the through-hole and into the fluid conduit and is interconnected with the poppet valve assembly such that the handle shaft assembly can be actuated to move the poppet valve assembly between the open position and the closed position. The retention member is insertable through the one or more openings and into the through-hole to interact with the handle shaft assembly to selectively hold the handle shaft assembly in the body.
US11634274B2 Bulk fluid storage container
A bulk fluid storage container has a top wall structure and a bottom wall structure held in spaced relation by a side wall structure. An internal baffle assembly is disposed in the fluid storage volume between the side wall structure for reducing fluid sloshing. A fill port formed in the top wall structure has a fill flange for coupling with a source of the fluid. A vent port formed in the top wall structure has a pressure vacuum value. A drain port formed in the side wall structure in a lower region adjacent the gutter region has a drain valve assembly is coupled to the drain port. A frame assembly includes an upper rectangular frame member and a lower rectangular frame member arranged in spaced relation by a plurality of post; wherein the frame assembly surrounds and supports the fluid storage vessel.
US11634273B2 Flexible container liner wringing device and liner
A liner (L) has a liner body (11) with a front wall (12), rear wall (16), bottom wall (13), a top wall (14). The top wall also includes a tubular excess liner material or chute (19) located close to the rear wall and which includes a filling fitment (20) with a fitment cap (21). The liner also has a cylindrical, hose content inlet/outlet port or bottom fitment (23). The liner may include a gap-filler or filler strip (90) of foam material extending outwardly from a position closely adjacent the outlet fitment. The filler strip is mounted to the front wall and/or top wall. The filler strip may taper so that at least a majority of the strip's longitudinal length or height so as to increase in its lateral width as it approaches the outlet fitment, thereby increasing the material volume of strip material.
US11634267B2 Pallet cover comprising one or more temperature-control members and kit for use in making the pallet cover
A pallet cover suitable for use in covering at least a portion of a payload on a pallet and a kit for use in making the pallet cover. In one embodiment, the pallet cover includes a top wall, a front wall, a rear wall, a left side wall, and a right side wall, wherein the walls are detachably joined to one another. Each of the top wall, the front wall, the rear wall, the left side wall, and the right side wall includes a first fabric sheet and a second fabric sheet, the first and second fabric sheets being joined together to form a plurality of pockets. Each pocket may removably receive a temperature-control member containing a phase-change material. At least one of the top wall, the front wall, the rear wall, the left side wall and the right side wall may include a plurality of detachably joined portions.
US11634261B2 Deflatable inflatable web
A protective packaging web is disclosed. The web includes a flexible inflatable web that includes inflatable chambers having inlets and configured for receiving a fluid from the inlets and sealing the fluid therein, the inflatable chambers being configured such that, when inflated, the inflatable web structure has a first contoured exterior surface including a plurality of peaks and valleys, and a flexible first outer ply affixed to the peaks and detached from the valleys of the first contoured surface, such that when the inflatable chambers are inflated, the first outer ply extends along a phantom first tangential surface, bridging the valleys of the first contoured surface, such that when the chambers are inflated the affixed first outer ply and the inflatable web cooperatively form a framed structure having significantly elevated bending stiffness compared to a bending stiffness resulting from the inflatable web structure absent the attached first outer ply.
US11634253B2 Storage bag with colored lips
A storage bag has a first closure profile attached to a first side surface, with the first closure profile forming a lip between an interlocking member and an edge of the first closure profile. The bag also includes a second closure profile attached to the second side surface, with the second closure profile forming a lip between an interlocking member and an edge of the second closure profile. The lips of the first and second closure profiles are visually distinct colors or different shades of a color in order to aid the user in locating the lips.
US11634251B2 Knockdown crate and method of display packaging
A method for packaging and displaying knockdown crates for sale at a retail location is disclosed. The method of packaging and displaying knockdown crates generally includes: (a) providing one or more unassembled knockdown crates having two end panels, a bottom panel, and two side panels; (b) uniformly stacking and packing each unassembled knockdown crate into a rectangular tray; and (c) each rectangular tray containing an unassembled knockdown crate stacked into a display box, wherein the exterior of the display box advertises the contents therein for display at a retail location.
US11634244B2 Packaging machine and systems
A system for packaging one or more items includes an order arrangement station where the one or more items can be arranged into a stack with a desired configuration. A dimensioning mechanism determines the outer dimensions of the stack and a converting assembly creates a box template that when erected forms a box that is custom sized to the dimensions of the stack. A crowder assembly holds and maintains the stack in the desired configuration while the box template is at least partially folded around the stack. The box template is secured around the stack in the form of a box.
US11634242B1 Cleaning, filling, and capping containers
Systems and methods for filling and sealing a container can include a housing having an opening for receiving containers, a rotary assembly including mount assemblies disposed in the housing, the rotary assembly operable to rotate the of mount assemblies about a central axis, a washing station, a filling station, a steam injector, and cap setter disposed in the housing.
US11634241B1 Space foundry
Certain embodiments of the inventive technology may be described as apparatus for melting and reshaping metal from a first shape into a second shape in a microgravity or zero gravity environment, such as a space foundry, where such apparatus includes feedstock input componentry (5) configured to accept conductive metal feedstock (7) having the first shape, a furnace and a furnace pre-stage (22) established upflow of the furnace, a plurality of electromagnetic field generators (10), each of which is configured to generate an electromagnetic field, to, e.g., steer, melt and/or move the metal, whether melt or otherwise, and casting componentry (15) configured to reshape molten metal to the second shape. Certain embodiments may achieve a high degree of control over electromagnetic fields by offering individual adjustment of one or more electrical parameters of the electromagnetic field generators (10).
US11634236B2 Pilot interface for aircraft autothrottle control
An autothrottle for an aircraft that includes a power-control input (PCL) manually movable by a pilot along a travel path to effect a throttle setting that controls engine power of the aircraft. The autothrottle determines a control-target setting for a throttle of the aircraft and dynamically adjusts the throttle according to the control-target setting, including moving the PCL to achieve the control-target setting. A virtual detent is set and dynamically adjusted at positions along a travel path of the PCL corresponding to the control-target setting. The virtual detent is operative, at least when the autothrottle is in a disengaged state for autothrottle control, to indicate the control-target setting to the pilot via a haptic effect that applies a detent force opposing motion of the PCL in response to the PCL achieving the position of the virtual detent.
US11634233B2 Distributed battery bank for ducted-rotor aircraft
In an embodiment, a duct for a ducted-rotor aircraft includes a hub, the hub including a rotor and one or more motors configured to drive the rotor. The duct also includes a duct ring that defines an opening surrounding at least a portion of the hub. The duct also includes a plurality of stators that extend outward from the hub. The duct also includes at least one battery electrically coupled to the rotor and configured to power the one or more motors.
US11634231B2 Battery module for electrically-driven aircraft
A battery module can include multiple cell tubes, a first conductive plate, and multiple first spacers. The multiple cell tubes can accommodate multiple battery cells within the multiple cell tubes so that individual of the multiple battery cells are positioned within individual of the multiple cell tubes. The first conductive plate can include multiple first holes and electrically connect first terminals of the multiple cells. The multiple first spacers can be mounted in the multiple first holes and support the multiple tubes and the multiple cells with respect to the first conductive plate, the multiple first spacers being configured to provide thermal and electrical isolation between the multiple battery cells and the first conductive plate.
US11634227B2 Landing tracking control method and system based on lightweight twin network and unmanned aerial vehicle
A landing tracking control method comprises the following contents: a tracking model training stage and an unmanned aerial vehicle real-time tracking stage. The landing tracking control method extracts a network Snet by using a lightweight feature and makes modification, so that an extraction speed of the feature is increased to better meet a real-time requirement. Weight allocation on the importance of channel information is carried out to differentiate effective features more purposefully and utilize the features, so that the tracking precision is improved. In order to improve a training effect of the network, a loss function of an RPN network is optimized, a regression precision of a target frame is measured by using CIOU, and meanwhile, calculation of classified loss function is adjusted according to CIOU, and a relation between a regression network and classification network is enhanced.
US11634225B2 Information-processing device and information-processing method
Flight cessation detection unit detects that drone has ceased flying at an unexpected site. Situation information acquisition unit acquires, as situation information indicating a situation related to retrieval of the drone, information on weather in an area in which the drone has flown. Retrieval procedure determination unit determines a retrieval procedure for the drone based on a situation indicated by the acquired situation information. Retrieval procedure determination unit, upon detecting a time period having specific weather based on the acquired information on weather, determines a retrieval procedure in which the time period is designated as a retrieval time.
US11634223B2 Unmanned aerial vehicle control method, unmanned aerial vehicle control device, and computer readable storage medium
The present disclosure provides a control method of a UAV, a control device of a UAV, and a computer-readable storage medium, and relates to the technical field of UAVs. The control method of a UAV includes: determining a deviation between a vertical mapping point on the ground and a landing point of the UAV, the deviation comprising a deviation in a horizontal axis direction of a camera coordinate system and a deviation in a vertical axis direction of the camera coordinate system; and generating speed control amounts of the UAV in the horizontal axis direction and the vertical axis direction of the camera coordinate system by a controller, using the deviation in the horizontal axis direction and the deviation in the vertical axis direction.
US11634221B2 Unmanned aerial vehicle system with temperature control equipment
A temperature control equipment, adapted to control the temperature of a docking station for a UAV, wherein a cover of the docking station includes a first and a second vents. The temperature control equipment includes a first and a second temperature control devices. The first temperature control device includes a first and a second airflow openings, and the second temperature control device includes a third and a fourth airflow openings. The first, second, third, and fourth airflow openings, and the first and second vents form a first airflow path; or the first and second airflow openings, the first vent, and a third vent of the cover form a second airflow path; or the first, second, third, and fourth airflow openings, the first, second, and third vents, a fourth vent of the cover form a third airflow path. A heater is located on the first, second or third airflow path.
US11634217B2 Short takeoff and landing vehicle with forward swept wings
A vehicle includes a tilt rotor that is aft of a wing and that is attached to the wing via a pylon. The tilt rotor has an adjustable maximum downward angle from horizontal that is less than or equal to 60° and that is set via a setting associated with a flight computer. The vehicle takes off and lands using at least some lift from the wing and from the tilt rotor. In response to a change to the adjustable maximum downward angle, via the setting associated with the flight computer, which produces a new maximum downward angle: the flight computer updates an actuator authority database associated with the flight computer to reflect the new maximum downward angle. Using the updated actuator authority database that reflects the new maximum downward angle, the flight computer generates a rotor control signal for the tilt rotor.
US11634215B2 Flying object
A flying object according to the present invention has been developed to have a plurality of rotor blades or jet engines, and to reduce the risk of a crash even if any one of the rotor blades or jet engines is damaged. The flying object comprises: a flying fuselage; a plate-shaped protection member having a plurality of through-holes formed on the same circumference thereof; a driving means arranged in each of the through-holes; and a tilting means for tilting each of the driving means, or a rotating means for rotating the protection member around a shaft member, wherein the diameter of the protection member, the interval between the rotational axes of the rotor blades facing each other, the length of the shaft member, and the length of the flying fuselage have a predetermined ratio.
US11634209B2 Method for controlling at least one aerodynamic stabilizer member of a hybrid helicopter, and a hybrid helicopter
A method for optimizing the operation of at least one first propeller and of at least one second propeller of a hybrid helicopter. The method comprises the following step during a control phase: deflection, with an autopilot system, of at least one aerodynamic stabilizer member into a setpoint position having, with respect to a reference position, a target deflection angle that is a function of a setpoint deflection angle, the setpoint deflection angle being calculated by the autopilot system in order to compensate for a torque exerted by the lift rotor at zero sideslip.
US11634208B2 Rigid-flexible coupled UAV morphing wing and additive manufacturing method thereof
A rigid-flexible coupled unmanned aerial vehicle (UAV) morphing wing and an additive manufacturing method thereof are disclosed. A shape memory alloy (SMA) strip/wire for controlling the wing upward deformation and an SMA strip/wire for controlling the wing downward deformation are arranged alternately, and a plurality of reinforcing ribs are arranged at intervals on the SMA strips/wires for controlling the wing upward deformation and the SMA strips/wires for controlling the wing downward deformation. The SMA strips/wires for controlling the wing upward deformation and the SMA strips/wires for controlling the wing downward deformation are arranged on a flexible substrate, and are wrapped with an insulating covering. The SMA strips/wires for controlling the wing upward deformation and the SMA strips/wires for controlling the wing downward deformation each are provided with an electric heating element.
US11634205B2 Frame component and method for producing a frame component, frame and fuselage structure for an aircraft
A frame component for a frame of a fuselage structure of an aircraft includes a central web extending along a longitudinal direction and having an inner edge region with respect to a radial direction running transversely with respect to the longitudinal direction and an outer edge region with respect to the radial direction. An inner web is bent from the inner edge region of the central web towards a first side. An outer web is bent from the outer edge region of the central web towards the first side. The central web, the outer web and the inner web are produced integrally from a metal sheet and together define a C-shaped cross section of the frame component. At least one stringer recess is formed in the outer web and in the outer edge region of the central web. The central web has, in the region of the stringer recess, a first reinforcing formation which forms a protrusion on the first side of the central web.
US11634202B2 Cooling device for power source for ship propulsion device
The cooling device for a power source for a ship propulsion device that pumps up cooling water, from which foreign matters with sizes that cause clogging of a cooling water route have been removed, supplies the cooling water to a cooling water passage (30), and discharges the cooling water to outside after cooling a power source (10) includes: a cartridge-type filtration device (40, 73) that is provided at a midpoint of a first water passage (36, 71) in the cooling water route and incorporates a filter (45, 46) for filtrating foreign matters remaining in the cooling water; and a second water passage (38, 72) that is branched from the first water passage and adapted such that a valve member (53) is opened to cause the cooling water to flow in a case in which clogging occurs in the filter.
US11634188B2 Collecting electric scooters
Systems and methods for collecting electric scooters are described herein. In some embodiments, the systems and methods facilitate a “snaking” configuration of attaching, coupling, or fixing multiple electric scooters to one another. The snaking configuration enables multiple electric scooters to be collected together and moved to various locations, such as locations where the electric scooters can be rented, serviced, and so on. Further, the systems and methods enable any electric scooter to act as a collecting scooter, and thus a scooter share service or other fleet of scooters can manage the collection and provisioning of scooters in a location without special vehicles or equipment, among other benefits.
US11634187B2 Autoslide fifth wheel hitch
An example trailer hitch is disclosed. The example trailer hitch includes a trailer hitch including a base to be coupled to a vehicle bed of a vehicle, a carriage slidably coupled to the base, the carriage to slide along rails of the base between a first position and a second position, and a head rotatably coupled to the carriage, the carriage to slide from the first position to the second position in response to rotation of the head.
US11634186B2 Tugger train trailer, transport system, and transport method
A tugger train trailer is disclosed, including a frame and drive-on surfaces for holding a trolley cart. Transport vehicle drive-on surfaces for an autonomous transport vehicle moving the trolley cart are also provided such that a unit of trolley cart and autonomous transport vehicle can drive on the drive-on surfaces.
US11634184B2 Composite flooring for recreational vehicles
A composite floor is provided comprising a skeletal framework, foam core inserts, an impact resistant sheet, and a weather resistant sheet bonded together with adhesive. Recreational vehicles incorporating such floors are also contemplated, as are methods of making the composite floor.
US11634179B2 Multi-material vehicle roof stiffener
A vehicle roof stiffener includes at least one fiber reinforced polymer (FRP) portion and at least one metal or metal alloy portion. The FRP portion includes at least one transition structure including a metal or a metal alloy. At least some of the fibers of the FRP portion are embedded in the transition structure. The metal or metal alloy portion is secured to the transition structure of the FRP portion. In an example vehicle roof stiffener, the metal portion extends parallel to a longitudinal axis of a vehicle, and the FRP portion extends transverse to the longitudinal axis. The example vehicle roof stiffener may include a front FRP portion, a rear FRP portion, and two metal side portions. The metal side portions and the FRP portions may be joined by welding the transition structures to the metal portions.
US11634178B2 Front pillar outer
An objective of the present invention is to provide a front pillar outer that has high strength and high rigidity. In an area in which the first door-side flange part and a second door-side flange part overlap with each other, the first door-side flange part and the second door-side flange part are joined to each other. In an area in which the first glass-face-side flange part and the second glass-face-side flange part overlap with each other, the first glass-face-side flange part and the second glass-face-side flange part are joined to each other.
US11634177B2 Sub-frame mounting combination structure of vehicle body
A sub-frame mounting combination structure of a vehicle body may include a fender apron side member mounted at the rear end portion of a front side member in the longitudinal direction of the vehicle body, a first side extension disposed in the transverse direction of the vehicle body and connected to the inside of the fender apron side member, a second side extension disposed in the transverse direction and connected to the outside of the fender apron side member, a tunnel member disposed in the transverse direction connecting the first side extensions at both sides at the center portion of the vehicle body to each other, and having the same phase as the first side extension, and a cap type bracket disposed to cover the fender apron side member at a portion where the fender apron side member and the first and second side extensions are connected.
US11634176B2 Traveling route generation device and vehicle control device
An object of the present invention is to provide a traveling route generation device and a vehicle control device. A traveling route generation device according to the present invention includes: a travel region information acquisition unit acquiring travel region information; and a traveling route generation unit generating information of a curved line expressing a route along which the vehicle should proceed based on the travel region information, wherein an output of the traveling route generation unit is supplied to a vehicle controller performing steering control of the vehicle, and the traveling route generation unit increases weight of the travel region information in a range used for the steering control in the travel region information to be larger than weight of the travel region information in a range which is not used for the steering control to generate information of the curved line.
US11634173B2 Apparatus and method for controlling steer-by-wire system
A apparatus for controlling a steer-by-wire system including: a reaction torque generator configured to generate reaction torque as a calculated value of steering reaction torque applied to a steering wheel; a driver torque estimator configured to detect a driver torque estimation value as an estimated value of driver steering torque; a speed controller configured to generate a motor torque command value of a motor-driven power steering system; a torque adjuster configured to calibrate the motor torque command value and the reaction torque based on the driver torque estimation value, and output final active return torque and final reaction torque; and a target current generator configured to generate a target current for motor control by using the final active return torque and the final reaction torque, inputted from the torque adjuster, and input the generated target current to a motor.
US11634172B2 Steering device and steering system including steering devices
A steering device installed on a vehicle including a plurality of steerable wheels and configured to independently steer a wheel which is one of the plurality of steerable wheels, including: an electric motor as a drive source; a motion converting mechanism configured to convert a motion of the electric motor into a steering motion of the wheel; and a controller configured to control a supply current to the electric motor so as to achieve steering of the wheel corresponding to a motion position of the electric motor, wherein, to eliminate a discrepancy between the motion position of the electric motor and a steering position of the wheel detected based on the supply current to the electric motor supplied when the motion position of the electric motor is maintained at a straight-traveling-state position, the controller executes a reference change process of changing a setting of the straight-traveling-state position.
US11634170B2 Electric power-steering control device and electronic unit
An electric power-steering control device has a substrate, a heat-generating component, and a heat-storing body. The heat-generating component is disposed on one surface of the substrate and generates heat when activated. The heat-storing body is capable of storing the heat from the heat-generating components. The heat-storing body has a main body having a rectangular plate shape and disposed on the one surface of the substrate. The heat-storing body has a notch section or a recess section.
US11634168B2 Motor including connector and connector pin and electric power steering device including same
A motor includes a rotor including an axially extending shaft, a stator, a housing, a heat sink disposed axially above the stator, a board fixed axially above the heat sink, a connector disposed radially outside the housing, and a connector pin accommodated in the connector. The heat sink includes a main body, and a protrusion which is continuous with the main body, the protrusion extending radially outward of the housing. The connector, the protrusion, and the board overlap in this order when viewed from axially below. The connector pin is positioned radially outside the protrusion.
US11634167B1 Transmitting axial and rotational movement to a hub
In one aspect of the present disclosure, a combined suspension and steering module is disclosed that is positionable between an in-hub motor and a body of a vehicle. The module includes a housing, an actuator connected to the housing and including first and second components, and a steering system that is in mechanical cooperation with the actuator to rotate at least one of the first and second components in relation to the housing. The second component is axially movable in relation to the first component and is configured for connection to the in-hub motor to transmit rotational force from the actuator to the in-hub motor to cause angular displacement of the in-hub motor to thereby steer the vehicle.
US11634166B2 Support structure for airbag apparatus
A support structure for an airbag apparatus includes an airbag apparatus having a bag holder, a supporting member having a shaft portion, a slider, an annular damper holder, and an annular elastic member. The shaft portion extends in a front-rear direction, while being passed through the bag holder. The shaft portion includes a flange at the rear end. The slider is fitted around the shaft portion to be slidable in the front-rear direction. The damper holder covers part of the slider in the front-rear direction. The elastic member includes protrusions that protrude rearward from the elastic member so as to contact the flange, thereby partially filling a gap between the elastic member and the flange. The protrusions extend radially with an axis of the supporting member serving as a center.
US11634165B2 Robotic vehicle, system therewith and use thereof
Robotic vehicle and use thereof for displacing a holder for goods, which is for instance loaded with goods, which vehicle can be operated in an empty position and a loaded position, comprising of (1) moving the robotic vehicle to a position under the holder in a first direction, wherein the robotic vehicle is in the empty position, wherein a holding means is countersunk in a body of the vehicle; (2) lifting the holder, wherein the robotic vehicle lifts the holder by performing a vertical movement of the holding means relative to the wheels of the vehicle, such that the holding means comes into contact with an underside of the holder, wherein the robotic vehicle transfers to the loaded position; (3) rotating driven wheels of the robotic vehicle from the first direction to the second direction without the body of the vehicle being rotated, and (4) displacing the robotic vehicle in the loaded position in a second direction, wherein the first and second direction enclose a mutual angle of between 60 and 120 degrees, preferably 75 and 105 degrees, more preferably 85 and 95 degrees, such as a substantially right angle.
US11634160B2 Thermal management of steering system for autonomous vehicles
Aspects of the disclosure relate to a vehicle having an autonomous driving mode and a manual driving mode. The vehicle may include a steering system having one or more processors configured to control the orientation of the one or more wheels based on control commands. The vehicle may also include an autonomous driving control system configured to control the vehicle in an autonomous driving mode by generating the control commands and to send the control commands to the steering system. In addition, the steering system may thermally derate the steering system based on first temperature information for the steering system when the vehicle is operating in a manual drive mode, and the autonomous driving control system may thermally derate the steering system based on second temperature information for the steering system when the vehicle is operating in the autonomous driving mode.
US11634159B2 Determining an undesired action of a vehicle
It is presented a method performed in a vehicle action determiner for determining an undesired action of a first vehicle and a resulting action. The method comprises: detecting that a first user is focusing on the first vehicle; acquiring brain activity data of the first user; determining a negative reaction of the first user based on the brain activity data; determining when the first vehicle is performing an undesired action based on the first user focusing on the first vehicle and the negative reaction of the first user; determining the resulting action taken by an autonomous vehicle, based on the first vehicle performing the undesired action; and triggering the autonomous vehicle to perform the resulting action.
US11634155B2 Sequential fusion for 3D object detection
Techniques are provided for improving a perception processing pipeline for object detection that fuses image segmentation data (e.g., segmentation scores) with LiDAR points. The disclosed techniques are implemented using an architecture that accepts point clouds and images as input and estimates oriented 3D bounding boxes for all relevant object classes. In an embodiment, a method comprises: matching temporally, using one or more processors of a vehicle, points in a three-dimensional (3D) point cloud with an image; generating, using an image-based neural network, semantic data for the image; decorating, using the one or more processors, the points in the 3D point cloud with the semantic data; and estimating, using a 3D object detector with the decorated points as input, oriented 3D bounding boxes for the one or more objects.
US11634154B2 System and method for driving guide
Disclosed are a driving guide system and method. The driving guide system includes an input unit configured to receive signal information from a signal controller, a memory in which a driving guide program using the signal information is embedded, and a processor configured to execute the program. When it is not possible to recognize a traffic light using a camera, the processor determines a driving behavior using the signal information and then performs autonomous driving according to the driving behavior or provides a notification to a driver.
US11634150B2 Display device
A display device includes an electronic control unit configured to: obtain a traveling plan from an automatic driving system of a vehicle, the traveling plan including a course of the vehicle under automatic drive control of the automatic driving system; obtain, from the automatic driving system, a system confidence level of the automatic drive control calculated based on at least an external environment around the vehicle; and display, on a display, a pointer as an image indicating the course during the automatic drive control in a display mode set based on the system confidence level.
US11634142B2 Blind spot detection
Herein is disclosed a detection device comprising one or more sensors, configured to receive sensor input from a vicinity of a first vehicle, and to generate sensor data representing the received sensor input; one or more processors, configured to detect a second vehicle from the received sensor data; determine from the sensor data a region of a first type relative to the second vehicle and a region of a second type relative to the second vehicle; and control the first vehicle to avoid or reduce travel in the one or more regions of the first type or to travel from a region of the first type to a region of the second type.
US11634140B2 Vehicle control method and vehicle control device
The vehicle control device sets a region including a stationary object on a road, calculates a passing position at which a host vehicle and an oncoming vehicle pass each other in accordance with a velocity of the host vehicle and a position and a velocity of the oncoming vehicle, calculates a first score that is a larger value as the velocity of the oncoming vehicle is greater, calculates a second score that is a larger value as an acceleration rate of the oncoming vehicle is greater, integrates the first score with the second score so as to calculate an integration score, and causes the host vehicle to decelerate when the integration score is greater than or equal to a predetermined value or causing the host vehicle to keep the velocity or accelerate when the integration score is smaller than the predetermined value.
US11634139B2 Vehicle control device, vehicle control method, and storage medium
A vehicle control device in an embodiment includes a recognition unit that recognizes a surrounding situation of a vehicle and a driving control unit that controls one or both of steering and acceleration or deceleration of the vehicle on the basis of the surrounding situation recognized by the recognition unit, and in a case where the vehicle merges into a second lane from a first lane in which the vehicle travels, and a section of the second lane before merging recognized by the recognition unit is downhill, the driving control unit makes a speed or acceleration of the vehicle higher than in a case where the section before merging is not downhill.
US11634138B2 Electric vehicle
An electric vehicle according to an example of the present application includes a battery, a regenerative brake, a friction brake, and a controller. The regenerative brake imparts regenerative braking torque to drive wheels. The friction brake imparts frictional braking torque to the drive wheels and non-drive wheels. The controller execute a slip control when the slip of the drive wheels is expected. The controller controls, during the execution of slip control, the regenerative and the friction brakes so that; the total of the frictional and the regenerative braking torque imparted to the drive wheels is less than or equal to upper limit torque set within a range that the drive wheels do not slip; the power of the regenerative power generation is not to exceed an acceptable charging power set according to a state of charge of the battery; and the regenerative braking torque is smaller than the regenerative braking torque before the start of the slip control.
US11634136B2 Vehicular trailer hitching assist system
A vehicular trailer hitching assist system includes a camera disposed at a rear portion of a vehicle and viewing at least rearward of the vehicle. An electronic control unit (ECU) includes an image processor operable to process image data captured by the camera. The ECU, via image processing of image data captured by the camera, detects a trailer rearward of the vehicle and determines a first path of travel for the vehicle to follow to maneuver the vehicle toward the trailer and to align the tow ball of the vehicle with a trailer hitch of the trailer. The ECU generates an output to maneuver the vehicle along the determined first path of travel. Responsive to detection of an object entering the first path of travel, the ECU determines a second path of travel for the vehicle to follow that avoids the detected object entering the determined path of travel.
US11634134B2 Using discomfort for speed planning in responding to tailgating vehicles for autonomous vehicles
Aspects of the disclosure relate to controlling a first vehicle in an autonomous driving mode. While doing so, a second vehicle may be identified. This vehicle may be determined to be a tailgating vehicle. An initial allowable discomfort value representing expected discomfort of an occupant of the first vehicle and expected discomfort of an occupant of the second vehicle may be identified. Determining a speed profile for a future trajectory of the first vehicle that meets the value may be attempted based on a set of factors corresponding to a reaction of the tailgating vehicle. When a speed profile that meets the value cannot be determined, the value may be adjusted until a speed profile that meets the value is determined. The speed profile that meets an adjusted value is used to control the first vehicle in the autonomous driving mode.
US11634133B1 Adaptive automatic preventative braking (APB) distance
Methods, systems, and non-transitory computer-readable media are configured to perform operations comprising determining a lead obstacle in front of an ego vehicle; determining an optimizable function associated with an optimized preferred following distance between the ego vehicle and the lead obstacle; and generating the optimized preferred following distance based on the optimizable function.
US11634126B2 Apparatus, methods and articles to facilitate motion planning in environments having dynamic obstacles
A motion planner performs motion planning with collision assessment, using a motion planning lattice that represents configuration states of a primary agent (e.g., autonomous vehicle) as nodes and transitions between states as edges. The system may assign cost values to edges, the cost values representing probability or likelihood of collision for the corresponding transition. The cost values may additionally or alternatively represent a severity of collision, for example generated via a parametric function with two or more parameters and one or more weights. A primary agent and/or dynamic obstacles may be represented as respective oriented bounding boxes. Some obstacles (e.g., road markings, edge of road) may be represented as curves. A trajectory of a primary agent and/or dynamic obstacle may be represented by respective sets of fitted polynomial functions, edges on the planning graph, which represent transitions in states of the primary agent, the system sets value representing a probability of collision, and optionally representing a severity of the collision. The system then causes the actuator system of the primary agent to implement a motion plan with the applicable identified path based at least in part on the optimization.
US11634121B2 Driving assistance apparatus and driving assistance method for vehicle
In a driving assistance apparatus, an object detecting unit detects an object that is present in a periphery of an own vehicle based on an image captured by an imaging apparatus provided in the own vehicle. An avoidance control unit performs collision avoidance control for avoiding a collision between the detected object and the own vehicle when a collision between the object and the own vehicle is likely. A light distribution control unit switches irradiated light of an irradiation apparatus provided in the own vehicle between high beam and low beam based on a predetermined switching condition. The light distribution control unit performs switching suppression control to suppress switching of the irradiated light from high beam to low beam while the avoidance control unit is performing collision avoidance control in a case where the irradiated light is set to high beam.
US11634116B2 Control system for vehicle
A control system for a vehicle that executes a feedback control properly to adjust a speed of a predetermined rotary member to a target speed. A controller is configured to: calculate an amount of change in a torque applied to the rotary member by one of the torque devices, in accordance with operating conditions of the torque devices; and calculate an amount of change in the torque applied to the rotary member by another one of the torque devices, based on a target amount of change in a synthesized torque of the torques of the torque devices and the amount of change in the torque applied to the rotary member by one of the torque devices.
US11634113B2 System and method for controlling driving of electronic 4-wheel drive hybrid vehicle
A system and method for controlling driving of an electronic 4-wheel drive hybrid vehicle appropriately executes torque distribution and compensation to front wheels and rear wheels in each gear position to satisfy driver's requested torque depending on selected driving mode of the electronic 4-wheel drive hybrid vehicle in which an engine and a front wheel motor are connected to the front wheels and a rear wheel motor is connected to the rear wheels, thereby being capable of increasing acceleration performance when a sports mode is selected as the driving mode and realizing acceleration linearity when a comfort mode is selected as the driving mode.
US11634112B2 Hydraulic arrangement for tractor-trailer brake hydraulic circuits
A hydraulic arrangement for connecting a tractor hydraulic brake circuit to a trailer hydraulic brake circuit is disclosed. The hydraulic arrangement includes a coupler stage fluidly connecting a source of fluid in pressure to the trailer braking hydraulic circuit and a trailer brake valve fluidly connecting the tractor hydraulic brake circuit and the trailer hydraulic brake circuit. The hydraulic arrangement further includes a selection pilot stage fluidly connected to the source of fluid in pressure and being fluidly connectable to the trailer hydraulic brake circuit via at least a connector and a selection stage fluidly connected to the selection pilot stage and to the trailer brake valve. The selection stage being configured to impart an actuation signal to the trailer brake valve in function of an hydraulic signal coming from the selection pilot stage.
US11634111B2 Brake system and method for braking a motor vehicle
A brake system for a motor vehicle, having a first hydraulic brake device configured to brake wheels on a first axle of the motor vehicle, a first control unit configured to control the braking operation of the wheels on the first axle; and a second hydraulic brake device configured to brake the wheels on a second axle of the motor vehicle, and a second control unit configured to control the braking operation of the wheels on the second axle. The first control unit is coupled with the second control unit via a communication channel. The first control unit and the second control unit are each configured to receive data that are relevant for the control of the braking operation, the first control unit furthermore being configured to transmit a data signal on the basis of the received data via the communication channel to the second control unit.
US11634106B2 Electric vehicle with cleaning device
An electric vehicle with a cleaning device includes an electric motor, a cleaning device connected with a pipe installed in a vehicle cabin, a first clutch that connects and disconnects the electric motor with an axle of wheels of the vehicle, a second clutch that connects and disconnects the electric motor with the cleaning device, a control unit that controls one of the first clutch and the second clutch to selectively connect one of the cleaning device and the axle with the electric motor and activate the cleaning device.
US11634101B2 Removable component system
A removable component system may include a removable component selectively connectable to a mounting surface including a component electrical unit; an antenna; a system controller configured to communicate with the component electrical unit and the antenna; and/or a track assembly configured to be fixed to said mounting surface. The removable component may be selectively connectable to said mounting surface via the track assembly. The removable component may be configured for selective connection with, removal from, and movement along the track assembly. The system controller may be configured to obtain a position of the removable component relative to said mounting surface via the antenna and the component electrical unit (e.g., via a component controller, a sensor, and/or a communication device thereof).
US11634097B2 Apparatus for mounting curtain airbag cushion
An apparatus for mounting a curtain airbag cushion is proposed. The apparatus for mounting curtain airbag cushion includes an intermediate connection tap (200) and a strap (400) coupled to the curtain airbag cushion (1) by sewing (300), and a mounting plate (100) coupled to the intermediate connection tap (200) and securely coupled to a vehicle body (2). The mounting plate (100) is made of a steel material, thereby maintaining sufficient assembly torque when the mounting plate 100 is securely assembled to the vehicle body 2 by a medium of a bolt (500), and the intermediate connection tap (200) and the strap (400) coupled to the curtain airbag cushion (1) by sewing (300) are made of flexible fabric materials, thereby preventing the curtain airbag cushion (1) from being damaged by the intermediate connection tap (200) and the strap (400) in sewing 300.
US11634096B2 Seat-mounted occupant restraint system
A restraint system is provided for helping to protect an occupant of a vehicle having a roof and side structure defining a cabin with a seat for the occupant. The restraint system includes an airbag having a stored condition within the vehicle seat and being inflatable to deploy upwards in the cabin to a deployed condition between the occupant and the side structure. The airbag extends from an upper end positioned adjacent the roof to a lower end positioned adjacent a base of the seat. The airbag extends in a forward-rearward direction of the vehicle sufficient to span the entire depth of the seat in the forward-rearward direction.
US11634093B2 Seat module for cable arrangement
A seat module adapted to be attached to a seat having mechanical parts and electric devices for seat operation in a motor vehicle includes at least one operating cable for activating at least one device, and a module plate formed with a mounting feature for attaching to the seat and a retention feature for attaching the at least one operating cable. An end portion of the operating cable is temporarily stowed on the module plate in a pre-assembled state where the operating cable is attached to the module plate, and the end portion of the operating cable is connected to the electric devices and/or mechanical parts of the seat in an assembled state where the module plate with the retained operating cables is securely mounted to the seat.
US11634092B2 Wire harness capable of suppressing a decrease in insulation reliability
A wire harness including a plurality of first electric wire members that each have a first flexible electric wire and a hard electric wire electrically connected to the first flexible electric wire: a plurality of second electric wire members that are second flexible electric wires: a tube through which the plurality of first electric wire members and the plurality of second electric wire members pass: and a first fixing member for bundling the plurality of first electric wire members and the plurality of second electric wire members, wherein: the tube includes a bend closest to an end surface in a longitudinal direction of the tube, and the wire harness is configured to achieve a first arrangement and a second arrangement.
US11634090B2 Cover device for a side sill of a passenger vehicle
A cover device for a side sill of a passenger vehicle includes a sill cover which has a cover element securable on the side sill and a mobile cover element which is disposable in a length region of the side sill below a door opening of the passenger vehicle. The mobile cover element is displaceable between a covering position and an entry position by a drive unit and the drive unit, configured as a pre-assembled structural unit, has a motor and is disposed in a region of the cover element by a holding device. The motor is disposed on an outside of the cover element and protrudes into an interior of the sill cover with a motor shaft.
US11634084B2 Mount adapter assembly and method of use
A mount adapter assembly for facilitating attachment of articles to a mounting rack includes a first element and a second element. The first element is shaped substantially complementary to at least a first portion of an orifice positioned in a mounting rack. The first element is at least partially insertable into the first portion of the orifice from a first face of the mounting rack. The second element can abut the mounting rack from a second face of the mounting rack. A connector engages the first element to the second element so that the first element and the second element are coupled to the mounting rack. A fastener engaged to the first element can engage a substrate so that the substrate is coupled to the mounting rack. The substrate can be used to attach a variety of articles to the mounting rack.
US11634078B2 Vehicular rearview mirror control system
A vehicular rearview mirror control system includes a plurality of rearview mirror assemblies having variable reflectance mirror reflective elements. An electronic control unit receives image data captured by a rear backup camera of the vehicle. The rearview mirror control system, responsive to processing a first subset of received image data captured by the rear backup camera, determines ambient light rearward of the vehicle. The rearview mirror control system, responsive to processing a second subset of received image data captured by the rear backup camera, determines glare light emanating from a headlight of another vehicle following the equipped vehicle. The first subset of received image data is different than the second subset of received image data. The rearview mirror control system generates an output to control dimming of respective ones of the mirror reflective elements of the plurality of rearview mirror assemblies based on location of the determined glare light.
US11634068B2 Display device and display method for display device
A display device provided in a vehicle that travels autonomously includes: a display unit configured to display information to an outside of the vehicle; a determination unit configured to determine whether a travel state of the vehicle is any one of a deceleration state, a stop state, and a start state, based on a detection result of an internal sensor of the vehicle; and a display control unit configured to display on the display unit the information corresponding to each of the deceleration state, the stop state, and the start state, based on a determination result of the determination unit. In response to the determination unit having determined that the vehicle is in the deceleration state, the display control unit is configured to display on the display unit the information including a display moving from an upper side to a lower side along a vertical direction of the vehicle.
US11634066B2 Protective housing for automotive glazings and other applications
A protective housing wherein two parts (102, 104) of the housing may be closed together to encapsulate connectors and associated components that are external to the glazing laminate. The protective housing is sealed to the glazing and between the two parts to provide a fluid-tight housing. The parts of the protective housing are connected to the glazing and to each other by adhesive layers (116, 118, 120).A vehicle glazing (10) wherein a light guide stack (22) is located between a portion of the inner transparency (26) and the outer transparency (28). The light guide stack includes a polycarbonate film (32) that is bonded to the transparencies by layers of PET (38, 40) that are secured to the polycarbonate film on one side by silicone (34, 36) and that are secured to the transparencies on the other side by PVB (42, 44). The terminal end of an extending tab of the polycarbonate film forms an edge that is connected to a light bar (14) that such visible light propagates through the light bar and into the polycarbonate film through the edge. Visible light propagates through etchings in the smooth surface of the polycarbonate film to form an image. An extension of one of the transparencies protects the polycarbonate tab and supports the light bar during installation of the glazing into the vehicle portal.
US11634065B2 Control method and control device
A control method according to the present disclosure includes: obtaining (receiving) position information (a danger warning signal) indicating a target position where a target object is present; determining whether the vehicle is driving autonomously or is being driven manually; when the vehicle is determined to be being driven manually, inspecting whether the target position is located within a predetermined region of a travel route of the vehicle based on the position information; when the target position is located within the predetermined region, changing the light transmission state of the headlight from a first state to a second state; and when the vehicle is determined to be driving autonomously and/or the target position is not located within the predetermined region, maintaining the light transmission state of the headlight.
US11634064B1 Vehicular lamp fitting and radar structure
A vehicular lamp fitting and the like in which a radar unit can be replaced without replacing the whole vehicular lamp fitting are provided. A vehicular lamp fitting includes a lamp housing, an outer lens attached to the lamp housing and forming a lamp chamber between the outer lens and the lamp housing, a lamp unit disposed in the lamp chamber, a bracket, and a radar unit detachably fixed to the bracket.
US11634061B2 Proppant delivery system
An apparatus for delivering proppant to a well site includes a plurality of proppant containers. The apparatus also includes a support structure having a bed and a structural framework extending down from the bed. The plurality of proppant container are structurally supported on top of the bed. A bin is disposed within the structural frame work below the bed. A conveyor cooperates with the bin for transporting proppant from the bin to a desired location at the well site. Proppant discharged from one or more of the plurality of proppant containers positioned on the bed above the bin is received in the bin and delivered to the well site by the conveyor.
US11634059B2 Tray table tuning mechanism for passenger seat
Described are tray table tuning mechanisms for a passenger seat. The tray table tuning mechanisms can include a pivot limiting member, a paddle arm deployment member, an adjustment plate, and a paddle arm. The paddle arm deployment member and the adjustment plate may be pivoted relative to the pivot limiting member. The paddle arm can include at least one stop member and may be pivotably coupled to the paddle arm deployment member. Additionally, the paddle arm may be pivoted between a stowed state and a deployed state. In the deployed state, the stop member can abut a portion of the adjustment plate to limit rotation of the paddle arm deployment member in a first direction.
US11634058B2 Table for seat
A table for seat provided facing a seat installed above a floor of a vehicle, including a top plate, and a leg part attached to a support portion provided below the seat to movably support the top plate from an accommodation position below the sitting portion to a use position above a sitting portion of the seat. The leg part includes a movable portion, and a fixing device configured to fix a movement of the movable portion in conjunction with an operation of the top plate.
US11634057B2 Lower leg support device for a vehicle seat, and vehicle seat
A lower leg support device for a vehicle seat, with a bracket and with a lower leg support displaceably arranged on the bracket, which can be moved between a non-use position and a use position upstream in longitudinal extension, wherein the lower leg support has at least two support parts which are moveable relative to each other to increase or reduce a lower leg support surface of the lower leg support. It is provided that the support parts can be moved transversely to the longitudinal extension to each other in order to increase or reduce the width of the lower leg support surface.
US11634055B2 Seat assembly
A seat assembly may include a seat, a biomedical sensor, a bladder assembly, a pulsed electromagnetic field (PEMF) coil assembly, and/or an electronic control unit (ECU) connected with the biomedical sensor. The ECU may be configured to control the bladder assembly and the PEMF coil assembly, and/or to determine if a user occupying the seat is in a first state or a second state. The first state may correspond to one or more small user movements. Small user movements may include movements having magnitudes below a specified value or threshold. The second state may correspond to one or more large user movements. Large user movements may include movements having magnitudes above the specified value or threshold. The ECU may operate in a first mode when said user is in the first state and operate in a second mode when said user is in the second state.
US11634050B2 Occupant protection apparatus
An occupant protection apparatus includes a driver. The driver includes a drive unit, a support shaft, a movable seat pan supported by the support shaft such that the movable seat pan is inclinable in a front-rear direction, a guide groove, a movement pin that is movable along the guide groove, a link that couples the movable seat pan to the movement pin, and an energy absorber. The guide groove includes a first guide groove portion in which the movement pin moves when the movable seat pan is inclined rearward and a second guide groove portion in which the movement pin moves when the movable seat pan is inclined forward. The energy absorber is configured to absorb at least part of a forward load from an occupant when the movement pin moves in the second guide groove portion.
US11634046B2 Vehicle charging system and power receiving fitting body
A vehicle charging system includes: a power supply device including a power supply fitting body and provided in a stop space of a vehicle; and a power receiving fitting body that is provided on a bottom of the vehicle and is able to be fitted to and removed from the power supply fitting body in an insertion/removal direction. The power receiving fitting body includes power receiving terminals electrically connected no a battery provided in the vehicle, a power receiving terminal holding part that holds the power receiving terminals, and an opposite space forming part that is arranged adjacent to the power receiving terminal holding part in the insertion/removal direction and forms an opposite space facing the power receiving terminals.
US11634044B2 Charger plug release system
A charger plug release system for use with an electric vehicle is provided. The charger plug release system provides a preloaded outward force to the electric charging plug when the plug is electrically connected to a charging receptacle on the EV. When charging is completed, the plug may be released (e.g., via a mobile “app”), and the outward force applied by the system to the plug causes the plug to be ejected without manual intervention. Accordingly, the release system eliminates the need for the user to manually pull the plug from the EV charging receptacle, and instead, forcefully ejects the plug from the EV automatically. This allows the user to automatically remove the plug from the EV from within the vehicle or from another safe location.
US11634042B2 Apparatus and method for controlling locking of a charging inlet of a vehicle
An apparatus for controlling locking of a charging inlet includes a charging inlet including an input device configured to be provided at a position where pressurization is determined based on a type of a connector of a charging cable and to be engaged with the connector, an on board charger (OBC) configured to generate an inlet unlocking signal when the input device is pressurized by the connector, and a controller configured to unlock the charging inlet when the inlet unlocking signal is received.
US11634039B2 System and method for integrated battery charging and propulsion in plug-in electric vehicles
A system and method for integrated charging a vehicle includes a hybrid excitation machine, operable as a traction motor and including a rotor separated by an air gap from a stator with AC windings. An AC utility line power supply is connected to the AC windings providing an electrical current to the vehicle and inducing a magnetic flux across the air gap and in the rotor. A short circuit, an open circuit, or a DC voltage may be applied to a DC winding in the stator to reduce the magnetic flux into the rotor. A field coil in the rotor may be excited with a DC voltage using a secondary coil on the rotor in a traction mode. The secondary coil is excited by the stator windings using field-oriented control in a “self-excited machine” embodiment, and is directly excited by a separate primary coil in an “externally-excited machine” embodiment.
US11634038B2 Fuel cell system installed in vehicle
A fuel cell system installed in a vehicle includes: a fuel cell; a secondary battery; a load including a drive motor and an air compressor; a fuel cell converter; a secondary battery converter; a failure detection unit; a first state determination unit; a reverse rotation detection unit; and a control unit. The control unit performs a limp-home traveling control that supplies electric power from the secondary battery to the drive motor when the secondary battery converter fails. When the vehicle is not in the first state, the control unit prohibits regeneration of the drive motor. When the vehicle is in the first state, the control unit supplies a reaction current to the air compressor. When the reaction current is applied and a reverse rotation of the air compressor is detected, the control unit does not apply the reaction current thereafter.
US11634036B2 Vehicle having motor and method of controlling the same to prevent collision thereof
A method of controlling an electrified vehicle to prevent a collision thereof includes: determining whether an accelerator pedal is erroneously operated in the situation in which an obstacle is detected to be present in a traveling path; and when it is determined that the accelerator pedal is erroneously operated, performing braking control such that at least one of hydraulic braking or regenerative braking is selectively performed in a plurality of braking sections determined based on a current vehicle speed and a distance to the obstacle.
US11634034B1 Rapid transistor switching in a converter with limited capacitance
A power electronics converter includes a converter commutation cell having a power circuit and a gate driver circuit. The power circuit includes at least one power semiconductor switching element and at least one capacitor. Each power semiconductor switching element is included in a power semiconductor prepackage. The gate driver circuit is configured to provide switching signals to a gate terminal of each power semiconductor switching element, and a peak rated power output of the power electronics converter is greater than 25 kW and a value of a converter parameter γ is less than or equal to 150 fFs/W, where the converter parameter γ is a total rated capacitance of the at least one capacitor of the power circuit divided by a product of the peak rated power output of the power electronics converter and a maximum switching frequency of the switching signals.
US11634031B2 Work vehicle with fluid gauge accessible from the ground
A work vehicle includes: a chassis; an operator cab carried by the chassis; at least one fluid reservoir carried by the chassis; at least one fluid sensor disposed in the at least one fluid reservoir and configured to output a fluid level signal corresponding to a level of fluid in the at least one fluid reservoir; and a fluid display gauge carried by the chassis outside of the operator cab and operatively coupled to the at least one fluid sensor, the fluid display gauge including an activation region that is accessible from the ground. The fluid display gauge is configured to display the level of fluid in the at least one fluid reservoir upon the activation region being activated.
US11634030B2 Vehicle smart garnish
A vehicle smart garnish is provided. The vehicle smart garnish includes an upper casing formed with a plurality of symbols to which light is emitted, a capacitive touch sensor pad corresponding to at least one of the plurality of symbols and recognizing a touch, a holder casing in which the capacitive touch sensor pad is mounted and coupled from a rear of the upper casing, and a circuit board positioned behind the holder casing and on which a light emitting element emitting light is mounted and configured to detect a touch signal of the capacitive touch sensor pad, wherein the holder casing includes a light guide path for guiding the light emitted from the light emitting element to the plurality of symbols, and a light reflection layer is formed on a partition of the light guide path.
US11634020B2 Electrified vehicle battery packs with tear-away service panels
Exemplary battery pack designs for use in electrified vehicles may include an enclosure assembly that houses one or more battery internal components (e.g., battery arrays, battery electronic components, or both). A tear-away service panel may be positioned within a wall of the enclosure assembly. The service panel may be removed from the enclosure assembly to access one of the battery internal components requiring service and may be subsequently replaced with a replacement service panel. The replacement service panel may be part of a battery pack resealing kit.
US11634019B2 Vehicle exterior surface protective device
A vehicle exterior surface protective device for protecting a portion of a vehicle from damage by hail includes a shell, which defines an interior space, and a fastener. The shell is sized to cover a portion of an exterior surface of a vehicle, such as a window and a body panel. A first insert and a second insert are positioned in the interior space, adjacent to a top and a bottom of the shell, respectively. The first insert is at least semirigid and can resist impact deformation. The second insert is resiliently deformable and can dissipate a force from an impact of an object. The fastener is engaged to the shell and is selectively engageable to the vehicle to fixedly position the shell over the portion of the exterior surface. The shell thus positioned protects the portion of the exterior surface from the impact of the object.
US11634014B2 Retractable truck bed cover having slat array with flexible joiner members and shielded seams
A retractable truck bed cover having an array of parallel aluminum slats joined together by connective hinges including leading and trailing edge configuration for improving the security of the cover by covering and concealing the seam between adjacent slats while improving the connective hinge's resistance to the effects of aging and/or exposure to temperature fluctuations. The truck bed cover connective hinge slat is designed to be in an array of discrete slats, which are joined to one another by means of joiner members secured at each end to slat end caps. The distal ends of the joiner members are attached to slat end caps at the distal ends of the slats, thereby preventing the joiner members from shrinking in relationship to the slats due to aging and I or exposure to temperature fluctuations.
US11634010B2 Method for the start-up of an air-conditioning system, computer-readable storage medium, and air-conditioning system
The commissioning of an air conditioning system requires a series of manual steps, which leads to inefficient commissioning. A method is therefore provided for commissioning an air conditioning system of a vehicle, including the following: a) Reading in a target data record indicating a target vehicle state; b) Recording an actual data record indicating an actual vehicle state by measuring at least one signal and/or communicating with at least one vehicle component; c) Comparing the actual vehicle state with a target vehicle state; d) Activating at least one function of the air conditioning system only if the actual vehicle state corresponds to the target vehicle state.
US11634008B2 Heating system of vehicle
An indoor heating line is arranged to pass through a heater core for a coolant heater and indoor air conditioning, and is provided with a first pump so that coolant can flow. A battery heating line is branched from a downstream point of the heater core and connected to an upstream point of the coolant heater after passing through a battery heat exchange part for temperature-raising a high voltage battery, where the battery heating line includes a first heat exchange flow passage that connects a downstream point of the heater core to a first side of the battery heat exchange part, and a second heat exchange flow passage that connects a second side thereof and an upstream point of the coolant heater, where the first heat exchange flow passage and the second heat exchange flow passage are configured to mutually exchange heat.
US11634007B2 System implementing air quality-based waste management
A waste service management system, method, and computer program product improve waste services by responding to air quality that is outside and inside a waste service vehicle. A controller monitors at least one exterior air quality sensor that is mounted to, and exposed to air exterior to, the waste service vehicle. The controller monitors at least one interior air quality sensor that is mounted to the waste service vehicle and exposed to air interior to a waste hauling body that is one of carried and attached to the waste service vehicle. The controller compares measurement levels of exterior and interior airborne chemical constituents to one or more corresponding air quality thresholds. The controller presents a notification on a user interface device indicating any exceedance of the air quality threshold and an associated origin of one of the exterior air and the interior air.
US11634004B2 Integrated thermal management system for vehicles
An integrated thermal management system for vehicles includes: a first cooling line; a second cooling line; a refrigerant line; and a bypass line configured to diverge from the second cooling line, to be connected to a chiller, and to allow a coolant to bypass a second radiator and to circulate between a high-voltage battery and the chiller.
US11634002B2 Vehicle body frame using component integration type rear lower
An embodiment component integration type rear lower includes a body frame having an end portion of a first side and an end portion of a second side and having a predetermined length, a front-rear connection member connecting a side sill at the end portion of the first side and connecting a rear side member at the end portion of the second side, a bush mounting member coupling a bush to the end portion of the first side, and a coupled torsion beam axle (CTBA) mounting member coupled to at least one of a CTBA, a chassis spring, or a shock absorber, the at least one of the CTBA, the chassis spring, or the shock absorber being engaged with the end portion of the second side.
US11634000B2 Air suspension control
Example illustrations are directed to a suspension system for a vehicle, which includes a controller configured to determine a roughness of a ground surface associated with the vehicle. The controller may be further configured to determine a height adjustment parameter for the suspension system based on the roughness determined, and to facilitate modification of the suspension system based on the determined height adjustment parameter. Example methods are provided, which may include determining, using a controller, a roughness of a ground surface associated with a vehicle, the roughness determined based on ride height. The method may also include determining, using the controller, a height adjustment parameter for a suspension system of the vehicle based on the roughness determined.
US11633998B2 Suspension strut
A suspension strut for a vehicle comprises: a first connector for connecting to a first point on the vehicle; a second connector for connecting to a second point on the vehicle; and a damper assembly adapted to provide a damping force as fluid flows through the damper assembly during relative compression between the first point and the second point, wherein the damper assembly comprises a side wall and a damper aperture in the side wall, wherein the damper aperture is open throughout operation of the strut to allow fluid to flow through the damper assembly.
US11633997B2 Suspension system providing desired wheel kinematics at prescribed conditions
Systems are provided for suspensions that deliver desirable wheel kinematics at prescribed conditions. A system includes a vehicle body structure with an engine cradle, and an associated wheel assembly. A suspension system links the wheel assembly with the engine cradle, and includes a link coupled with the engine cradle and coupled with the wheel assembly. A joint at the link includes a flange that has an opening, an edge, and at least one undercut defined in edge of the flange. The joint allows release of the wheel assembly from the engine cradle by designed tearing between the opening and the at least one undercut. The release is initiated only under loads above a select threshold at the joint, to provide select kinematics of the wheel assembly for specific operational cases.
US11633992B2 Tire
The tire can achieve both cut resistance and mud drainage performance of the sidewall. The tire includes: a tread; sidewalls; and a plurality of side block groups on at least one of the sidewalls. Each of the side block groups protrudes from the sidewall reference plane. Each of the side block groups includes: a first side block; and a second side block. In each of said plurality of side block groups, the fi3 . . . 3rst side block 2 has a groove 23 extending from the second side block 3 toward an inside of the first side block in the tire circumferential direction D3, In each of said plurality of side block groups, the second side block 3 has a slope 35c whose height from the reference plane S2 becomes lower toward the first side block, such that the slope extends into the groove of the first side block.
US11633991B2 Tire provided with a texture on a sidewall
A tire made of rubbery material comprises tread (12) and two sidewalls (14) delimiting the tread, at least one of the sidewalls comprising at least one texture (16) that contrasts with the rest of the sidewall. The texture is divided into a plurality of adjacent patterns (18, 20) of identical external shape. All or some of the patterns comprise a plurality of texture elements arranged to form in the pattern a plurality of rows that extend in the same direction of extension. For a given pattern of the texture, the rows of texture elements in each pattern adjacent to the given pattern have a direction of extension different from the direction of extension of the rows of texture elements of the given pattern. The lightness of the rest of the sidewall, which is not textured, is at least 5 units greater than the lightnesses of the patterns of the texture.
US11633988B2 Pneumatic tire
In a pneumatic tire, a groove depth H1 of each of first and second inclined lug grooves over an entire region from an opening portion to a corresponding one of first or second circumferential main grooves to a terminating end portion within a center land portion has a relationship with a maximum groove depth Hg of the corresponding one of the first or second circumferential main grooves represented by 0.80≤H1/Hg≤1.00. Additionally, a maximum groove depth H2 of each of first and second lateral grooves has a relationship with a groove depth H1e at a terminating end portion of the corresponding one of the first and second inclined lug grooves represented by 0.70≤H2/H1e≤0.90.
US11633987B2 Tire
A tire includes a tread portion including a circumferential groove and a land portion defined by the circumferential groove, the land portion including a land sidewall facing the circumferential groove. The land sidewall includes a first surface, a second surface located on a groove centerline side of the circumferential groove with respect to the first surface, and a stair portion formed between the first surface and the second surface. The stair portion varies its radial height stepwise in two or more steps in a longitudinal direction of the circumferential groove.
US11633985B2 Wheel comprising a non-pneumatic tire
A wheel for a vehicle (e.g., a construction vehicle, an all-terrain vehicle, or other off-road vehicle) or other device, in which the wheel comprises a non-pneumatic tire and may be designed to enhance its use and performance and/or use and performance of the vehicle or other device, including, for example, to be able to be used longer and/or in more challenging conditions, such as, for instance, by being more thermally efficient (e.g., to avoid or reduce adverse effects such as rapid degradation in material properties that could otherwise arise due to excessive temperatures) and/or more resistant to cracking or other damage which could lead to premature failure (e.g., due to manufacturing artifacts and/or rocks and other hazards that can cut, chip, or tear it during use).
US11633982B2 All-terrain load transport system
An all-terrain load transport system including a cylindrical first base member and at least three pairs of arms is provided. A handle is removably attached to an attachment member disposed on the cylindrical first base member. The cylindrical first base member defines a space for receiving at least one piece of accessory equipment. Each pair of the three pairs of arms defines a wheel support assembly at an end of each pair distal from an outer periphery of the cylindrical first base member. The three pairs of arms are detachably attached to the outer periphery of the cylindrical first base member. The wheel support assembly includes a cylindrical second base member defining a space for receiving a spherical wheel. The spherical wheel moves omnidirectionally within the defined space. Roller bearings positioned along an inner periphery of the cylindrical second base member facilitate the omnidirectional movement of the spherical wheel.
US11633978B2 Hubcap for heavy-duty vehicles
A hubcap for a heavy-duty duty vehicle that includes mounting structure that is formed with and cooperates with a side wall of the hubcap to provide a stiff, rigid structure that enables non-cantilevered connection to a wheel hub. The mounting structure can be a plurality of elongated bosses circumferentially spaced about the side wall that are formed with corresponding elongated bolt openings to enable the non-cantilevered attachment to the wheel hub. The elongated bosses cooperate with the hubcap side wall to provide a stiffened or rigid structure between the elongated bolt openings for increased and more uniform clamping force on a sealing gasket between the hubcap and the wheel hub. The hubcap profile provides clearance for removal of an outboard mounted disc brake rotor in heavy-duty vehicle wheel end assemblies that include such rotor configurations. The hubcap may support simple mounting of a hub odometer.
US11633977B2 Vibration absorber for vehicle wheels
A vibration absorber for vehicle wheels is capable of absorbing and attenuating vibration of a vehicle wheel and of increasing a vibration absorption capability of the wheel without changing the external appearance and design of the wheel. The vibration absorber includes a vibration absorption unit mounted on a back surface of a center cap of the vehicle wheel to absorb a first vibration in an axial direction of the wheel transmitted through the center cap.
US11633975B2 Base extension assembly
A base extension assembly for measuring angles on a radiused corner includes a base that has a blade slot extending therein to insertably receive a blade of a combination square. The base has a channel is integrated therein to receive an anvil of the combination square. The base has a width that is greater than the width of the anvil such that the base extends beyond a radius of a corner is measured with the combination square thereby enhancing accuracy of the combination square. A pair of plates is each of the plates is positionable on the base to retain the anvil of the combination square in the channel.
US11633974B1 Modular binder assembly
A modular binder assembly for storing a variety of objects includes a binder which includes a first portion that is hingedly attached to a second portion. A plurality of first mating members is each coupled to a respective one of the first portion and the second portion of the binder. A document folder is removably attachable to respective ones of the first mating members for insertably receiving documents. A cassette caddy is removably attachable to respective ones of the first mating members. A personal electronic device is removably attachable to a respective one of the first mating members on the binder thereby facilitating the personal electronic device to be positioned at a variety of locations on the binder.
US11633971B2 Ribbon reeling mechanism and tape printing apparatus
A ribbon reeling mechanism includes: a gear supporting member that supports a clutch gear rotatably and is configured to move between a mesh position at which the clutch gear supported by the gear supporting member is in mesh with a first reeling-side gear and a non-mesh position at which the clutch gear supported by the gear supporting member is not in mesh with the first reeling-side gear; a clutch impeding spring that causes a clutch impeding force of impeding movement from the mesh position to the non-mesh position to act on the gear supporting member when a feed motor starts rotating in the second rotation direction; a drive member engaged with the gear supporting member; and a clutch drive mechanism that causes the gear supporting member to move to the non-mesh position against the clutch impeding force when the feed motor rotates in the second rotation direction.
US11633968B2 Low-particle gas enclosure systems and methods
A method comprises processing a substrate in a gas enclosure to form a film on one or more portions of the substrate. The method further comprises, while processing the substrate, circulating gas along a circulation path through the gas enclosure. Circulating the gas may comprise flowing gas through an exhaust housing enclosing a printhead assembly housed in the gas enclosure and filtering the gas flowing downstream of the printhead assembly from the exhaust housing.
US11633966B2 Cutter device and printing apparatus
A cutter device including a transport unit for transporting a medium, a round blade configured to move, while rotating, in a width direction intersecting a transport direction in which the medium is transported, a fixed blade provided along the width direction, and a controller configured to control driving of the transport unit and a movement in the width direction of the round blade, in which the controller is configured, when the medium is cut by causing the round blade to move to a first direction of the width direction, to cause the round blade to move to a second direction being a direction opposite to the first direction while causing the round blade to rotate without causing the medium to move in the transport direction.
US11633963B2 Fixation unit for use in a printing system
A fixation unit for use in a printing apparatus includes a substantially closed box for enclosing a heated space, the substantially closed box including an entry opening and an exit opening for enabling transport of a print substrate through the substantially closed box, a heating element arranged for heating the heated space enclosed by the substantially closed box, and a transport mechanism for engaging a sheet of the print substrate from the entry opening to the exit opening of the substantially closed box. The transport mechanism includes a nip of two belts that are pressed together and run concurrently and in the same direction, the belts being impermeable to any ink component. A printer includes such a fixation unit and a printing method uses such a fixation unit.
US11633961B2 Printing methods and systems
A method of controlling a system including a printhead for printing an image on at least one surface, wherein the at least one surface differs in shape from a nominal surface by a known tolerance, and wherein the printhead and the at least one surface move relative to each other along a predetermined print path comprising at least one swathe. Small dot patterns (referred to as “pathfinders”) are printed on a surface of the object in a preliminary printing pass, then the printed dot patterns are analyzed, for example with a machine vision system. The necessary corrections may then be calculated from this analysis and applied to a subsequent full printing pass.
US11633960B2 Print head and image forming apparatus
According to an embodiment, a print head includes one or more light emitting element arrays, a light emission control circuit, and one or more drive circuit arrays. The light emitting element arrays include a plurality of light emitting elements arrayed continuously along a main scanning direction. The light emission control circuit outputs drive signals of different phases in units of a light emitting element group configured by a predetermined number of continuous light emitting elements included in the light emitting elements. The drive circuit arrays include a plurality of drive circuits, the drive circuits cause the light emitting elements to emit light individually based on the drive signals.
US11633959B2 Thermal print head
The present disclosure provides a thermal print head for achieving fine printing. A thermal print head of the disclosure includes: a substrate, having a substrate main surface and a substrate back surface facing opposite sides in a z direction; a resistor layer, disposed on a side of the substrate main surface and including a plurality of heat generating portions arranged in a main scan direction to generate heat by energization; a wiring layer, disposed on the side of the substrate main surface and including a conduction path for electrically conducting the plurality of heat generating portions; a metal layer, interposed between the substrate and the wiring layer with the resistor layer; and an insulating layer, interposed between the metal layer and the wiring layer with the resistor layer. The conduction path includes the metal layer. The metal layer includes tantalum (Ta).
US11633955B2 Liquid-consuming apparatus
A liquid-consuming apparatus includes: a tank including a liquid storage chamber which stores a liquid, an inlet formed in a surface of the tank, and an outlet through which the liquid from the liquid storage chamber flows; a cap which is movable between a first position and a second position; a cover which is movable relative to the tank between a closed position and an open position; and a holding member which is connected to the cap and which holds the cap at the second position. The cap at the second position or the holding member is configured to obstruct a movement of the cover from the open position to the closed position.
US11633954B2 Recording apparatus
A recording apparatus includes a conveyance unit that conveys a recording medium in a first direction toward a recording head for ejecting a liquid, a tank including a containing chamber containing the liquid to be supplied to the recording head, and an injection port through which the liquid is injected into the containing chamber, the tank being disposed downstream of the conveyance unit in the first direction, a rotatable lever that holds a tank cap for closing the injection port, and a cover that rotates about a rotation shaft between an open position for exposing the lever and a closed position for covering the lever, the rotation shaft being disposed upstream of the conveyance unit in the first direction. The cover includes a sliding portion that is provided on a surface facing the lever and comes into contact with the lever while the cover is rotating toward the closed position.
US11633951B2 Printing device and composition comprising magnetic-color-changeable microcapsules
This disclosure relates to a printing device for printing or dispensing a curable printing composition which is capable of changing color in response to the application of a magnetic field in the non-cured state. The printing device may be a handheld device such as a portable pen. The present disclosure further relates to curable compositions, cartridges and methods which may be used in combination with the aforementioned printing devices or in other applications.
US11633944B2 Acoustic fibrous decoupler
Moulded three-dimensional noise attenuating trim part for a vehicle, comprising at least a three layer system consisting of a first porous fibrous layer and a second porous fibrous layer and an air permeable intermediate film layer situated between the first and second porous fibrous layers and wherein the adjacent surfaces within the three layer system are interconnected, wherein the second porous fibrous layer has an area weight AW2 that is varying over the surface and wherein at least for areas of the three layer system with a total thickness t between 5 and 35 mm, the area weight AW2 relates to the total thickness t of the three layer system as following 25*t+175
US11633943B2 Protection film and manufacturing method thereof, display panel and display device
A protection film, a method of manufacturing the protection film are provides, a display panel and a display device. The protection film includes a main portion and at least one cover surrounded by the main portion. The cover is at least partially connected to the main portion. At least part of an edge of the cover is a first edge, and the first edge and the main portion are not fixed.
US11633940B2 Compositionally modulated zinc-manganese multilayered coatings
The present disclosure provides electrolyte solutions for electrodeposition of zinc-manganese alloys, methods of forming electrolyte solutions, methods of electrodepositing zinc-manganese alloys, and multilayered zinc-manganese alloys. An electrolyte solution for electroplating can include a metal salt, boric acid, an alkali metal chloride, polyethylene glycol, and a hydroxy benzaldehyde. An electrolyte solution can be formed by dissolving a metal salt, boric acid, an alkali metal chloride, polyethylene glycol, and a hydroxy benzaldehyde in water or an aqueous solution. Electrodepositing zinc-manganese alloys on a substrate can include introducing a cathode and an anode into an electrolyte solution comprising a metal salt, boric acid, an alkali metal chloride, polyethylene glycol, and a hydroxy benzaldehyde. Electrodepositing can further include passing a current between the cathode and the anode through the electrolyte solution to deposit zinc and manganese onto the cathode.
US11633931B2 Thermoplastic composite part manufacturing system and method
A method and apparatus for a continuous compression molding machine. The continuous compression molding machine comprises a tooling die, extending through a heating zone and a cooling zone, a tooling sleeve, and a biasing system. The tooling sleeve corresponds to the tooling die and is for use in forming a thermoplastic composite part from a thermoplastic composite charge when the tooling sleeve with the thermoplastic composite charge is moved with respect to the tooling die through the heating zone and the cooling zone. The biasing system is configured to hold the thermoplastic charge at a first angle within the heating zone and hold the thermoplastic composite charge at a second angle within the cooling zone, as the tooling sleeve moves through the heating zone and the cooling zone with the thermoplastic composite charge. The first angle is different from the second angle.
US11633928B2 Spectacle lens and method for producing a spectacle lens
A spectacle lens, which is manufactured by additive manufacturing, includes interspersing first volume elements and second volume elements. The first and second volume elements are arranged on the grid points of a geometric grid to form a first sub-grid and a second sub-grid, respectively. The first sub-grid forms the first part of the spectacle lens having a dioptric effect for vision for a first object distance and the second sub-grid forms the second part of the spectacle lens having a dioptric effect for vision for a second object distance, which differs from the first object distance.
US11633927B2 System and apparatus for manufacturing simple curvature thermoplastic composite parts
A system for manufacturing a composite part including a conductive flexible facesheet and an automated tape layup (ATL) machine for laying up composite tape onto the facesheet that is laid flat on a flat surface. The system also includes a curved tooling surface for transferring the facesheet with the composite material thereon to the curved tooling surface for attachment of substructures and curing into the composite part. System may also include insulation placed below the facesheet and insulation placed above the composite material, as well as a source of electricity and heat for heating the conductive facesheet to cure, melt, or fuse the composite tape and substructures without heating the tooling surface and other tooling used in the composite curing process. Heating of the facesheet may be performed using joule heat provided by a single turn transformer inducing current to conductive wires attached at opposing ends to the facesheet.
US11633926B2 Aligned fiber reinforced molding
Methods and apparatus for additive manufactures of complex parts using co-aligned continuous fibers are disclosed. Filament subunits having complex shapes are fabricated and inserted into a mold cavity. The layup is compression molded to form a complex part having high tensile strength.
US11633922B2 Near-field microwave heating system and method
A microwave heating device includes a variable frequency microwave power supply, a waveguide launcher, and a fixture to contain a material to be heated, with the fixture located directly adjacent to the end of the launcher. All heating occurs in the near-field region, i.e., no cavity modes or standing waves are established within the fixture. This condition may be insured by keeping the thickness of the fixture or workpiece under one wavelength (at all microwave frequencies being used). The launcher is preferably a horn configured to spread the microwave power laterally over a selected area while maintaining a single propagating mode. The invention may be used to enhance catalytic reactions for research and other purposes. Alternatively, the invention may be configured to perform spot curing or repair operations involving adhesives and composites.
US11633917B2 Laser additive manufacturing control system and method
A computational method for controlling a powder particle uptake by a shielding gas in a laser additive manufacturing system. The computational method includes receiving a gas fluid domain, a powder bed domain, and an inlet shielding gas flow velocity of the laser additive manufacturing system. The method further includes determining a maximum gas flow velocity within the gas fluid domain based on the inlet shielding gas flow velocity and the gas fluid domain. The method also includes determining a threshold uptake flow velocity within the gas fluid domain based on the inlet shielding gas flow velocity and the powder bed domain. The method also includes controlling the powder particle uptake of the shielding gas in the laser additive manufacturing system in response to the maximum gas flow velocity and the threshold uptake flow velocity.
US11633914B2 Configurable printing bed for 3D printing
A configurable printing bed for a 3D printer includes a bed surface and linear actuators. The bed surface includes bed surface portions. Each of the bed surface portions is supported for independent movement. When each of the bed surface portions is positioned at the reference level, the bed surface portions form different parts of a common plane. Each of the linear actuators is connected to at least one of the bed surface portions, respectively. The linear actuators are configured to generate the independent movement of the bed surface portions and to effect positioning of the bed surface portions. A 3D printer includes the configurable printing bed, an extruder, a feeding system, and a filament spool. A method for performing 3D printing includes providing the 3D printer and printing an object using the 3D printer.
US11633905B2 Long decorative material with embossing in register with pattern and rolling method and device therefor
A long decorative material with an embossing in register with a pattern, a rolling method and a device therefor are described herein. The method comprises a feeding step of feeding a layered raw material of a long decorative material to be rolled into oppositely rolling rollers; and a rolling step of hot rolling an embossing on the transparent plastic layer. A feeding tension of a printed plastic layer is adjusted according to a longitudinal deviation between the embossing and the pattern in the rolling step. The device comprises a first feeding device, a second feeding device, the oppositely rolling rollers, a detecting device, and a tension controller disposed on the second feeding device. According to the long decorative material with the embossing in register with the pattern manufactured by the method, the embossing hot-rolled on the transparent plastic layer is in register with the pattern on the printed plastic layer. The method, device and the long decorative material with the embossing in register with the pattern processed thereby can implement the embossing on the transparent plastic layer in register with the pattern on the printed plastic layer and have high production efficiency, low cost and less energy consumption.
US11633895B2 System of injection-moulding machine closing units
A system of injection-moulding machine closing units is provided. In addition to two closing units of a first kind and third kind in a standard program, the closing units having closing forces F1 and F2, a further closing unit of a second kind having a closing force F1 is provided. The closing unit of the second kind forms an intermediate variable and is formed from components of the closing units of the first and third kind provided. The platens and the support plate with the dimensions of the closing unit of the third kind (closing force F2) and the toggle lever mechanism of the closing unit of the first kind (closing force F1) and the drive thereof are combined with one another. The articulated levers of the toggle lever mechanism of the closing unit of the second kind are hinged to the support plate and movable platen at a greater distance from the axis of symmetry than the articulated levers of the toggle lever mechanism of the closing unit of the first kind. The articulated levers themselves are identical. At the same time, the crosshead of the closing unit of the second kind is larger in the direction of the articulated levers of the toggle lever mechanism than the crosshead of the closing unit of the first kind such that the toggle lever mechanisms of the two closing units have the same kinematics.
US11633894B2 Core molding device
A cavity includes a first cavity portion, and a second cavity portion that is formed between the first cavity portion and a runner and that corresponds to a baseboard. There is adopted a configuration in which a foamed admixture is supplied to the first cavity portion via the second cavity portion upon being supplied to the cavity via the runner. A collision portion with which the foamed admixture supplied to the cavity can collide before reaching the first cavity portion is formed at the second cavity portion.
US11633892B2 Metal-resin bonded member and method of manufacturing the same
An object is to provide a metal-resin bonded member that is easy to manufacture and has high bonding strength. The metal-resin bonded member includes a metal body having an iron oxide layer on the surface and a resin body bonded to the metal body via the iron oxide layer. The iron oxide layer has a thickness of 50 nm to 10 μm. The iron oxide layer comprises 60-40 at % Fe and 40-60 at % O at the outermost surface side. The iron oxide layer contains magnetite (Fe3O4). The iron oxide layer is formed by heating the surface of an iron-based substrate at 200-850° C. in an oxidation atmosphere. The resin body is composed of polyphenylene sulfide (PPS). The bonding of the metal body and the resin body via the iron oxide layer can be carried out by insert molding, thermal adhesion utilizing friction heating, etc.
US11633891B2 Injection molding system
An injection molding system according to an aspect of the present disclosure is for performing insert molding, and includes: an opening-closing mechanism configured to open and close a pair of molds; an injection device configured to inject a resin into a space that is formed between the pair of molds when the pair of molds has been closed; and a positioning mechanism having a holding member configured to hold an insert part, the positioning mechanism configured to position the insert part between the pair of molds, and to cause the holding member to continue holding the insert part between the pair of molds even after the opening-closing mechanism starts to operate to close the pair of molds.
US11633889B2 Assembly appliance for mould tool parts of an injection moulding tool, an injection moulding tool and an injection moulding machine
An assembly appliance for mould tool parts of an injection moulding tool is disclosed, the assembly appliance including an assembly plate configured for insertion into an injection moulding machine and including a tool carrier for receiving first mould tool parts to be assembled; and an assembly frame having a guide system for a translatory displacement of the assembly plate along a longitudinal extension of the assembly frame, and a support device for stationary support of a second mould tool part which corresponds to at least one of the first mould tool parts.
US11633885B2 Lazarev reactor 2: continuous production process of films of two- dimensional polymers
The present disclosure provides device having a reaction vessel with one or more permeable membranes disposed therein that separate the reaction vessel into at least a first portion and a second portion. The one or more membranes permit first reactants from a first solution in the first portion or reactants from a second solution in the second portion to seep or percolate to a reaction zone proximate a surface of the one or more membranes. A reaction of the first and second reactants forms a two-dimensional polymer film material. A roller located inside of the reaction vessel draws the two-dimensional polymer film material reaction out of the reaction zone.
US11633880B2 Cleaning agent composition and molding raw material
A cleaning agent composition contains 100 parts by weight of polyethylene oxide; 25 parts by weight to 90 parts by weight of at least one type of fatty acid ester that is selected from glycerin fatty acid ester, polyglycerin fatty acid ester, or sorbitan fatty acid ester; and 15 parts by weight to 45 parts by weight of a metal salt of a fatty acid and/or a hydroxyfatty acid. The cleaning agent composition is used for cleaning a flow channel for resin in a hot runner type mold.
US11633875B2 Bottom face processing method of pillar-shaped honeycomb structure, manufacturing method of fired honeycomb structure, and manufacturing method of joined body
A bottom face processing method of a pillar-shaped honeycomb structure including steps of: preparing a pillar-shaped honeycomb structure including a plurality of first cells which extend in parallel with each other from a first bottom face to a second bottom face, and each of which is opened in the first bottom face and has a protruding plugged portion in the second bottom face, and a plurality of second cells each of which is adjacent to at least one of the first cells with a partition wall interposed therebetween, which extend in parallel with each other from the first bottom face to the second bottom face, and each of which has a protruding plugged portion in the first bottom face, and is opened in the second bottom face; and removing the protruding portion from the plugged portion of each of the first cells and the second cells of the pillar-shaped honeycomb structure.
US11633873B2 Finger joint cutterhead with adjustable insert knives positioning system
A mechanism for adjusting the position of a knife on a rotary cutterhead mounted for rotation about a central axis comprises at least three dynamics positioning points for allowing a user to adjust the knife axially, radially and tangentially with respect to the central axis of the cutterhead.
US11633871B2 Linear cut to length system for inline production of processed tubing
A system for cutting medical tubing sourced from a spool of tubing uses two actuator groups that each reciprocate along a respective track, which are parallel to each other. Each actuator group has a clamp and a cutting tool which have an operative position along a common axis. The tubing is fed along the common axis to be operated on by the actuator groups. A forward actuator group clamps onto the tubing and is then moved along its track, pulling the tubing. A rearward actuator group then clamps onto the tubing and cuts the tubing. While still clamped onto the tubing, the rearward actuator group is moved forward, pulling more tubing, and the actuator group that was forward is moved to the rearward position and the process is repeated iteratively to produce tubing sections cut to the desired length. The tubing is pressurized and kept under pressure to straighten the tubing.
US11633870B1 Compression/corner-cut box reducer
A box reducer for trimming or reducing the size of a cardboard box is disclosed. The current invention allows an operator to reduce the size of an existing cardboard box after unnecessary material is removed by a knife or a cutter. The current invention improves prior arts in two ways. First, the invention contains a stabilizer which allows itself to travel in a stable way along the top edge of the flaps of the cardboard box while marking a line to be folded to create the cover of the box. Second, instead of using perforation as prior arts do, this invention uses compression to create the line on the flaps of the cardboard box. Then the operator can fold along the line to create the covering flaps, thus, a reduced box.
US11633869B1 Biodegradable disposable safely shaving razor
A biodegradable unisex disposable safety razor includes an ergonomic handle and a fixed head arranged on one end of the handle. The head includes a skin contacting surface, an internal process cavity with a single blade having a single cutting edge. The blade communicates with four independent passages located on the head. The device, which functions with no moving parts and/or electronics has an integrated and enhanced; skin lubrication system, an acoustic alert method for achieving an optimal shave, a method to alternate the shaving blade material temperature, dependent care assist functionality, a fully internal surface wetting antibacterial protection method, an external user safety protection guard, a post shave debris clean-out in conjunction to a fully internal material surface dry-out sanitization system aimed at improving the devices overall hygiene.
US11633868B2 Electric beard trimmer
The present invention relates to a cutter system for an electric shaver and/or trimmer, comprising a pair of cooperating cutting elements movably supported relative to each other by a support structure, wherein one of the cutting elements is sandwiched between the other cutting element and the support structure, wherein cutting teeth in a middle section of the row are different from cutting teeth in end sections of the row in terms of at least one of shape, size and position of the tooth tips.
US11633867B1 Folding knife
A folding knife includes a handle, a first liner inside the handle, and a second liner inside the handle and opposed to tire first liner. A blade has a tang and a cutting edge, and the tang of the blade pivotally connects the blade between the first and second liners. The blade has a retracted position in which the cutting edge is inside the handle and a deployed position in which the cutting edge is outside the handle. An actuator is at least partially between the first and second liners. A screw inside the handle has a first end opposed to a second end. The first end of the screw is engaged with the first liner, and the second end of the screw is threadingly engaged with the second liner.
US11633861B2 Systems, methods and associated components for robotic manipulation of physical objects
Systems, methods, and associated components for robotic manipulation of physical objects. The physical objects include three-dimensional gripping features configured to be detected by an optics system and gripped by an end-effector of a robotic arm with sufficient gripping force to move the physical objects against the force of gravity. Sets of the physical objects can have different sizes and shapes and, in some examples, include identically constructed three-dimensional gripping features.
US11633860B2 Method and system for machine concept understanding
A system and method for machine understanding, using program induction, includes a visual cognitive computer including a set of components designed to execute predetermined primitive functions. The method includes determining programs using a program induction engine that interfaces with the visual cognitive computer to discover programs using the predetermined primitive functions and/or executes the discovered programs based on an input.
US11633859B2 Robot
A robot including a robot mechanism including joints and drive units, a control unit controlling the drive units so that an inspection operation to inspect one target drive unit among the drive units is executed by the robot mechanism, and a notification unit notifying maintenance information of the target drive unit based on a current value of a motor of the target drive unit during the inspection operation, or on information associated with the current value, and the inspection operation includes transmitting, to the motor of the target drive unit, control command to rotate a joint as much as a predetermined rotation angle, and thereby moving a tip of the robot mechanism or a tool at the tip, close to an object at a predetermined position from a predetermined start position, to press the object, and separating the tip of the robot mechanism or the tool away from the object.
US11633848B2 Independent pan of coaxial robotic arm and perception housing
A robotic device may include a spine defining a yaw axis. The robotic device may also include an arm joint rotatably connected to the spine at a first position along the yaw axis and configured to rotate about the yaw axis. The robotic device may further include an actuator including a ring that defines a bore. The spine may be fixedly connected to the ring at a second position along the yaw axis and may extend through the bore. The actuator may be connected to the arm joint and configured to rotate the arm joint about the yaw axis without rotating the spine.
US11633844B2 Hand held surgical handle assembly, surgical adapters for use between surgical handle assembly and surgical loading units, and methods of use
A surgical device includes an adapter assembly that selectively interconnects a loading unit and a device housing. The adapter assembly includes a drive converter assembly for interconnecting a rotatable drive shaft and an axially translatable drive member of the loading unit. The drive converter assembly converts and transmits a rotation of the rotatable drive shaft to an axial translation of the axially translatable drive member of the loading unit. The drive converter assembly includes a drive element, a drive nut, and a distal drive member. The drive element defines a longitudinal axis. The drive nut is disposed about the longitudinal axis, and the distal drive member is disposed along the longitudinal axis.
US11633843B2 Percussion tool
A percussion tool is used for performing a chiseling operation on a workpiece with a chisel. The percussion tool comprises a housing including a cylinder portion, a tool holder coupled to the cylinder portion for holding the chisel, and a percussion mechanism including a striker supported for reciprocation in the cylinder portion. The percussion mechanism is configured to impart repeated axial impacts to the chisel with the striker. The percussion tool further comprises a flange between the cylinder portion and the tool holder. Movement of the chisel within the tool holder toward the percussion mechanism is stopped by the flange.
US11633841B2 Method for controlling nail-striking operation of an electric nail gun, and electric nail gun implementing the same
A method for controlling a nail-striking operation of an electric nail gun is proposed. The electric nail gun includes a control module and at least one switch. The at least one switch outputs a first switch signal that has a first voltage and a second switch signal that has a second voltage when triggered. The control module set a flag that corresponds to the at least one switch to a predetermined state upon determining that a striking condition is met. The striking condition includes that, for each of the at least one switch, the first switch signal has the first voltage and the second switch signal has the second voltage.
US11633840B2 Electric nail gun
An electric nail gun includes a nail-striking subunit that is adapted to strike a nail, a lifting wheel that is movable to become engageable and not engageable with the nail-striking subunit, a driving member that is rotatable by a motor, and a transmission shaft that is movably connected between the driving member and the lifting wheel, and that is convertible between a first position, where the lifting wheel is engageable with the nail-striking subunit such that rotation of the driving member results in movement of the nail-striking subunit, and a second position, where the lifting wheel is not engageable with the nail-striking subunit such that rotation of the driving member does not result in movement of the nail-striking subunit.
US11633838B1 Gear puller having improved puller arms for stability in operation thereof
A gear puller assembly includes a yoke that defines a plurality of puller arm receiving interfaces, a threaded jack shaft threadably received through the yoke and having a pressing surface on an end thereof, and a plurality of puller arms, wherein each respective puller arm is configured for being selectively engageable with a respective puller arm interface of the yoke. A detent assembly extends from the yoke through each of the puller arm receiving interfaces, each of the detent assemblies configured for engagement with respective puller arms to cause the puller arm to maintain a locked position defined at an angle between the respective puller arms and the yoke.
US11633836B2 Removing apparatus
A removing apparatus includes a main body, an operation member, and two connection members. The main body has a main arm, and a first and second side arms on two ends, so as to form a C shape, with a combination bore on one end of one side arm away from the main arm. The operation member is on another side arm and axially movable, with another combination bore on one end of the operation member. Each connection member has a base portion, with an insertion portion extending from the one lateral side of the base portion to be combined with the combination bore. Each connection member has a large and a small column portions connected in a stage shape to form a stage face. Sleeves of different sizes can be combined with the lateral side or the stage face of the connection member for removing objects.
US11633835B2 Systems for managing abrasive media in cavitated fluid
Systems for managing abrasive media in cavitated fluid include a set of sensors in communication with cavitated fluid in a processing tank and a processor coupled to the set of sensors. The processor is configured to determine a density of an abrasive media in the cavitated fluid in the processing tank and facilitate maintaining the density of abrasive media in the cavitated fluid in the processing tank at a level that is greater than or equal to a threshold level of abrasive media. The processor is further configured to command the abrasive media addition device to add the recycled abrasive media to the processing tank to increase the density of abrasive media in the cavitated fluid in response to determining that an average density of abrasive media is less than the threshold density of abrasive media.
US11633830B2 CMP polishing pad with uniform window
A polishing pad useful in chemical mechanical polishing comprising a polishing portion having a top polishing surface and comprising a polishing material an opening through the polishing pad, and a transparent window within the opening in the polishing pad, the transparent window being secured to the polishing pad and being transparent to at least one of magnetic and optical signals, the transparent window having a thickness and a top surface having a plurality of elements separated by interconnected recesses to provide a pattern in the top surface that includes recesses for improved deflection into a cavity in the polishing pad during polishing.
US11633829B2 External heating system for use in chemical mechanical polishing system
A chemical mechanical polishing (CMP) system includes a polishing pad configured to polish a substrate. The CMP system further includes a heating system configured to adjust a temperature of the polishing pad. The heating system comprises at least one heating element spaced apart from the polishing pad. The CMP system further includes a sensor configured to measure the temperature of the polishing pad.
US11633826B2 Hand-held machine tool having a suction hose
A hand-held machine tool having a, in particular rod-shaped, handle element for an operator to grasp and having a machining head, which is movably mounted on the handle element by means of a joint assembly and which has an electric drive motor for driving a tool holder for holding a machining tool, wherein a bottom side of the handle element and a machining side of the machining head face a workpiece in a base position of the machining head, wherein the joint assembly is connected to the machining head in an articulated-connection region of the machining head, wherein a flexible suction hose for conducting a suction flow from the machining head to the handle element extends between the handle element and the machining head, which suction hose is fastened to an end region of the handle element by means of a first hose end and to a suction connection of the machining head by means of a second hose end.
US11633825B2 Acoustic crankpin location detection
A grinding machine including one or more grinding wheels has a workpiece holder that releasably holds a crankshaft and is configured to rotate the crankshaft about a longitudinal axis; a spindle assembly, that is moveable in at least two directions, including a spindle shaft and a grinding wheel attached to the spindle shaft; and an acoustic emission sensor coupled to the grinding machine, such that the grinding machine is configured to monitor an output signal from the acoustic emission sensor, move the grinding wheel into contact with the crankshaft at a first angular position, detect contact between the grinding wheel and the crankshaft based on the output signal, determine a position of the grinding wheel based on the detected contact between the grinding wheel and the crankshaft, move the grinding wheel away from the crankshaft, rotate the crankshaft a defined angular amount, move the grinding wheel into contact with the crankshaft at a second angular position, determine a position of the grinding wheel based on the detected contact between the grinding wheel and the crankshaft, and determine a position of a crankshaft surface.
US11633824B2 Grinding cavity body of multiple vibration sources
The present invention discloses a grinding cavity body of multiple vibration sources, in which a plurality of ultrasonic vibration sources are disposed, capable of controlling the multi-directional macroscopic medium flow, making benefits to the vibration medium (the abrasive of the slurry) to enter the fine structure of the workpiece to be processed, and to the abrasive to vibrate itself slightly to enhance the performance of abrasive to the workpiece which needs to be ground.
US11633821B2 Cutting apparatus
A cutting apparatus includes a cutting unit that has a spindle with an annular cutting blade mounted to a tip part of the spindle through a blade mount, and a determining unit. The determining unit has a second flow path that is connected to a first flow path in a mounter of the blade mount for causing a negative or positive pressure to act on the first flow path, a measuring device that obtains a measured value of at least one of a pressure and a flow rate in the second flow path, and a screw-engaged state determining section that determines that a screw-engaged state of a fixed nut with a boss section of the mounter where the cutting blade is disposed is defective in a case where the measured value when the negative or positive pressure acts on the first flow path indicates an abnormal value.
US11633819B1 O-ring installation tool and method of installing an O-ring in an inner diameter
Tool for installing O-rings in an inner diameter of a structure includes a plurality of held in a spaced, fixed parallel relationship to one another. A plurality of guide surfaces are secured with and disposed between the plates. A selectively-actuable finger actuator is disposed to move a plurality of fingers generally radially between the plurality of plates. Each of the plates includes a slot, and a loading pin is configured to be received within the slots. When at least one O-ring is disposed about a plurality of guide surfaces proximal the periphery of the plates, and the loading pin is moved within the slots, the loading pin pulls a loop of the O-rings toward the plate axis. When the loading pin is removed, the finger actuator may be actuated to move the fingers in the generally radial direction to move the at least one O-ring radially outward from the plates.
US11633815B2 Solder paste
Provided is a solder paste which uses a conventional flux, and for which long-term preservation is made possible and an easy preservation method can be realized by suppressing changes in the viscosity of the paste over time. This solder paste is provided with a solder powder, a zirconium oxide powder, and a flux, and changes in the viscosity of the paste over time are suppressed.
US11633812B2 Machine learning device, laser machine, and laser machining system
A machine learning device performs machine learning on a laser machine including a plurality of galvanometer mirrors for reflection of a laser beam and a plurality of galvanometer motors for driving the galvanometer mirrors to rotate, and scanning the laser beam over a workpiece. The machine learning device includes: input data acquisition unit that acquires at least two detected temperatures from the galvanometer mirrors and the galvanometer motors as input data; label acquisition unit that acquires a coefficient as a label for calculating a machining target position from an actual position of machining with the laser beam on the workpiece; and learning unit that performs supervised learning using a set of the label and the input data as training data to construct a mathematical model for calculating the machining target position from the actual machining position on the workpiece based on the at least two detected temperatures.
US11633811B2 Method of peening lap fillet welded joint and welded structures
A peening method which can sufficiently improve fatigue properties of a lap fillet welded joint having a thin steel sheet as a base sheet, in which a knocking pin having a predetermined shape is continuously knocked as a series of knocking toward a direction inclined relative to the welding direction, the series of knocking is repeatedly performed in the welding direction, at that time, a knocking mark group made of a plurality of knocking marks formed by the series of knocking is superimposed on at least a part of an adjacent knocking mark group while an end part in the direction orthogonal to the welding direction of the knocking mark group is separated from an end part in the direction orthogonal to the welding direction of the adjacent knocking mark group.
US11633806B1 Method to fill heat pipe arrays
A fill tool system that fills, seals, and inspects a heat pipe array, which includes one or more heat pipes with heat pipe working fluid.
US11633801B2 Resistance welding by means of robots
A method for electric welding a workpiece arrangement having at least one workpiece with the aid of a robot arrangement including at least one robot. A rotational movement is carried out between the workpiece arrangement to be welded and at least one welding electrode which contacts the workpiece arrangement. The rotational movement is started as a function of a commanded and/or detected welding start and/or ended as a function of a commanded and/or detected welding end. The direction of rotation of the movement may be changed as a function of a predefined parameter during contact between the welding electrode and the workpiece arrangement.
US11633799B2 Control assembly fabrication via brazing
Systems and methods to control fabrication of an assembly involve a first end sheet having an interior surface and an exterior surface, opposite the interior surface. A system includes interior sheets, the interior sheets including a first interior sheet at one end of a stack of the interior sheets and including a last interior sheet at an opposite end of the stack of the two or more interior sheets, the first interior sheet being adjacent to the interior surface of the first end sheet, and a second end sheet having an interior surface and an exterior surface, opposite the interior surface. The last interior sheet is adjacent to the interior surface of the last end sheet, and the interior surface of the first end sheet or the second end sheet includes venting features, the venting features including holes or slots to channel heat, gas, or vapor during a brazing process.
US11633797B2 Braze joints for a component and methods of forming the same
A system for creating a braze joint within a component. The system includes an environment operable to reach a braze temperature sufficient to melt at least a portion of a braze material. The system also includes a component within the environment, the component including a base having a base surface, a recess depending from the base surface into the base to an inner edge, and a braze material within the recess and forming a cap above the base surface. The braze material fills the recess from the cap to the inner edge. The cap has an exposed braze surface. The system also includes an insulation layer that at least partially covers the exposed braze surface.
US11633796B2 Process for producing a plate heat exchanger and plate heat exchanger
A plate heat exchanger has two metal plates brought into abutment, with a solder material between the plates. The plates are heated up to a first temperature. The plates are placed into a mold, the mold surfaces of which have cavities for envisaged channel structures. Channel structures are formed by local internal pressure forming of at least one plate under pressurization by the tool. The plates are heated up to a second temperature. The plates are solder bonded at the abuted surfaces. A plate heat exchanger has two metal plates, wherein channel structures have been formed in at least one plate and the plates are bonded to one another by soldering away from the channel structures. Eutectic microstructures having a longest extent of less than 50 micrometers are formed in the solder layer.
US11633794B2 Control device for and method of operating a metal clad cable cutting machine
A control device according to some embodiments of the disclosure includes one or more motors directed by the control device to form whip(s) from a length of a cable by causing the cutting of the cable in accordance with specifications based at least in part on whip information. An interface communicates the whip information between the control device and a user device.
US11633792B2 Apparatus for providing a complete tool
An apparatus for provisioning, in particular automatically, a complete tool having a toolholder and a tool, in particular a drilling and/or milling tool. The apparatus has a spindle that can be driven in rotation by a driving device. The spindle has a holding device for holding a toolholder. A measuring device, in particular an optical measuring device, measures a complete tool, held on the spindle. A heating device in the region of the spindle heats a shrink-fit chuck of the toolholder held on the spindle. A cooling device, in particular a cooling device associated with the spindle, enables the spindle and/or the complete tool held on the spindle, to be cooled.
US11633791B2 Apparatus for additive manufacturing of three-dimensional objects
An additive manufacturing apparatus may include a process chamber, a coating device, a shielding device, and a guiding device. The process chamber may include first and second working plane areas. The first working plane area may include a construction plane, and the second working plane area may house at least a part of the guiding device. The coating device may include a coating element assembly group that is, movably supported relative to the construction plane by the guiding device, and at least one coating element configured to form construction material layers in the construction plane. The shielding device may shield the second working plane area from intrusion of construction material or impurities from the first working plane area. The shielding device may include a shielding band, and the shielding band may be coupled for movement with the coating element assembly group. The shielding band may be guided movably along a plurality of supporting points that define an interior region of the second working plane area, and the guiding device may be arranged or formed above the first working plane area.
US11633786B2 Feedstock for an additive manufacturing method, additive manufacturing method using the same, and article obtained therefrom
A feedstock for a 3D manufacturing process, in particular a Fused Filament Fabrication process. The feedstock includes (P) sinterable particles made of a metal, metal alloy, glass, ceramic material, or a mixture thereof; and (B) a binder composition including (b1) 5-15% by weight, relative to the total weight of the binder composition, of a polymeric compatibilizer, and (b2) 85-95% by weight, relative to the total weight of the binder composition, of a polymeric binder component, the polymeric binder component being selected from the group consisting of (b2-1) a polymer mixture or polymer alloy, the mixture or alloy including at least a first and a second polymer; (b2-2) one, two or more block copolymers, including at least a first polymer block and second polymer block; and (b2-3) mixtures of (b2-1) and (b2-2), wherein the amount of sinterable particles P is 40 Vol % or more of the composition.
US11633785B2 Mechanically alloyed powder feedstock
Disclosed herein are embodiments of mechanically alloyed powder feedstock and methods for spheroidizing them using microwave plasma processing. The spheroidized powder can be used in metal injection molding processes, hot isostatic processing, and additive manufacturing. In some embodiments, mechanical milling, such as ball milling, can be used to prepare high entropy alloys for microwave plasma processing.
US11633784B2 Metal-ceramic composite powders
A process for manufacturing metal-ceramic composite material powder comprising ball milling metal powder and ceramic nanoparticles to yield a metal-ceramic composite powder comprising ceramic nanoparticles embedded in a metal matrix powder particles; wherein the ball milling is performed using a ceramic milling media and a milling vessel having a ceramic interior surface. Metal matrix nanocomposite powders comprising ceramic nanoparticles imbedded in metal matrix powder particles; wherein the metal matrix powder particles have a spherical shape; wherein there is uniform distribution the ceramic nanoparticles; wherein the nanocomposite powders have good flowability.
US11633780B2 Die for deforming material in a joining tool, joining tool and method for identifying and/or decetcting the condition of a die
A die for deforming a workpiece material in a joining tool comprises a head with a top side partially defining a cavity in which the workpiece material is to be deformed, a bottom side opposite the top side, a lateral side arranged between the top side and the bottom side, and a stem which extends along a longitudinal axis from the bottom side of the head. The die further comprises an identification tag, preferably an RFID tag, having an antenna for receiving and/or transmitting a signal, and a storing element for storing information, and the antenna is wrapped circumferentially around the head, such that the antenna entirely surrounds the head. The head may also include a groove extending around the head on the lateral side with the antenna arranged in the groove. Additionally, the die may include a recess with the storing element located in the recess.
US11633776B2 Apparatus and method for working bars
An apparatus for working bars includes a plurality of containing devices disposed adjacent and parallel to each other with an oblong development in respective longitudinal directions to contain a respective bundle of bars. At least one work station is located downstream of the containing devices. The work station includes at least one removal device to remove at least one bar from one of the containing devices, at least one drawing unit configured to move the bars in a direction of feed parallel to the longitudinal directions, and at least one bending device configured to bend the bars At least one drive member is associated with the work station, configured to move work station in a transverse direction with respect to the longitudinal directions in order to take the removal device into correspondence with one or the other of the containing devices, which are substantially fixed in position.
US11633771B2 Press methods for coated steels and uses of steels
Examples of methods of hot forming structural components are provided. The methods include heating a blank made from an Ultra High Strength Steel with an aluminum coating and forming the heated blank in a multi-step apparatus.
US11633765B2 System for cleaning semiconductor wafers
A system for controlling damages in cleaning a semiconductor wafer comprising features of patterned structures, the system comprising: a wafer holder for temporary restraining a semiconductor wafer during a cleaning process; an inlet for delivering a cleaning liquid over a surface of the semiconductor wafer; a sonic generator configured to alternately operate at a first frequency and a first power level for a first predetermined period of time and at a second frequency and a second power level for a second predetermined period of time, to impart sonic energy to the cleaning liquid, the first predetermined period of time and the second predetermined period of time consecutively following one another; and a controller programmed to provide the cleaning parameters, wherein at least one of the cleaning parameters is determined such that a percentage of damaged features as a result of the imparting sonic energy is lower than a predetermined threshold.
US11633755B2 Complex flow tube for fine sealing coating of PVC material for automobile and manufacturing method therefor
A complex flow tube for fine sealing coating of a PVC material for an automobile includes a base fixed to a mechanical arm, and a pipeline connected to the base for delivering a PVC sealant; the base is detachably butted with an interface of a PVC gluing pump mounted on the mechanical arm; the PVC gluing pump delivers the PVC sealant through the pipeline to a part to be coated or sealed of the automobile. The complex flow tube may be combined with the metal 3D printing technology, so that the manufactured complex flow tube has the advantages of being convenient to use, simple in structure, high in strength, not liable to break, etc.
US11633752B2 Scrubber unit for a paint booth
A paint booth assembly includes a paint booth having a pair of side walls and a flood sheet extending between the pair of side walls to separate the paint booth between a spray portion disposed above the flood sheet and a paint recovery portion disposed below the flood sheet. The flood sheet defines at least one flood sheet opening, and a scrubber unit extends down from the flood sheet opening to establish a shared path of fluid communication of a flow of water from the flood sheet and a downdraft of process air from the spray portion to the paint recovery portion. A scrubber pod is disposed within the scrubber unit and defines a plurality of perforations to induce an initial mixing of the paint particles entrained in the downdraft of process air into the flow of water.
US11633746B2 Air treatment apparatus
A docking station for a robotic surface cleaning apparatus has a momentum separator. The momentum separator has an upper wall, a lower wall and a first sidewall extending between the upper and lower walls. The first sidewall comprises a side screen and an end wall is spaced from and faces the side screen whereby an up flow chamber is positioned between the end wall and the side screen. The upper wall also comprises an upper screen and an upper end wall is spaced from and faces the upper screen wherein an upper air flow chamber is positioned between the upper end wall and the upper screen.
US11633737B2 Microfluidic chip for focussing a stream of particulate containing fluid
A microfluidic chip for focussing a stream of particulate containing fluid comprises a sample microfluidic channel configured to receive the stream of particulate containing fluid, a guidance microfluidic channel having a polygonal cross-sectional area and configured to receive a stream of guidance fluid, and a common microfluidic channel having a polygonal cross sectional area formed by the merging of the sample microfluidic channel and the guidance 10 microfluidic channel at an oblique angle along only part of one or more sides of the guidance microfluidic channel, and a detection zone disposed in the common microfluidic channel having one or more sensors. The merging of the sample microfluidic channel and the guidance microfluidic channel is configured to provide a composite fluid stream containing a focussed beam of particulates that is disposed asymmetrically in the common microfluidic channel 15 adjacent a corner or side of the common microfluidic channel and wherein the one or more sensors are configured for sensing a characteristic of the focussed beam of particulates in the common channel.
US11633736B2 Optical reaction well for assay device
This disclosure relates to an apparatus for simultaneously filling a plurality of sample chambers. In one aspect, the apparatus comprises a common fluid source and a plurality of independent, continuous fluidic pathways. Each independent, continuous fluidic pathway comprises a sample chamber and a pneumatic compartment. The sample chamber is connected to the common fluid source, and the pneumatic compartment is connected to the sample chamber. The sample chamber comprises, in part, an assay chamber. The assay chamber comprises a monolithic substrate and a plug having optically transmissive properties. In some embodiments, the assay chamber contains a magnetic mixing element. In some embodiments, the assay chamber is a double tapered chamber. In some embodiments, a ratio of a volume of the sample chamber to a volume of the pneumatic compartment is substantially equivalent for each fluidic pathway of the plurality of fluidic pathways.
US11633733B2 Integrated fluid module and test device
An integrated testing device and fluid module are disclosed, as well as a method of manufacture. Fluid module contains a reservoir containing a test fluid, and a control vessel. The reservoir discharges test fluid into the control vessel, which discharges the test fluid in a controlled way to a test component.
US11633731B2 Holding apparatus for holding a pipetting container at a pipetting device
The invention relates to a holding apparatus for holding a pipetting container, in particular a serological pipette, at a pipetting apparatus, comprising a tubular connecting section that is configured to hold a tube-shaped end of a pipetting container in a pipetting position by means of a clamping connection, a clamping connection device that is arranged at the connecting section and that comprises a spring device for the establishment of the clamping connection and an air chamber device for releasing the clamping connection by means of a vacuum. Furthermore, the invention relates to a pipetting apparatus with that holding apparatus.
US11633730B2 Cell sorter in a sealed system under controlled atmosphere
The present invention relates generally to an apparatus that is able to provide a sealed chamber system including a cell sorter, that allows for various oxygen tensions of choice to be maintained during cell harvest, sorting (and isolation of sub-populations of cells), analysis, etc.
US11633729B2 Particles with radial variation
A polymeric bead having radius R wherein the polymer comprises 0.3% to 20% by weight, based on the weight of the polymer, of polymerized units of one or more multifunctional vinyl monomer and 80% to 99.7% by weight, based on the weight of the polymer, of polymerized units of one or more monofunctional vinyl monomer, (a) wherein the polymerized units of multifunctional vinyl monomer have radial distribution factor MR of 0.9 to 1.1, and (b) wherein some of the vinyl groups in the polymerized units of multivinyl monomer are unreacted, and the unreacted vinyl groups have a radial distribution factor VR of 2.5 or higher.
US11633728B2 Nanoparticles of CO complexes of zero-valent metals that can be used as hydrosilylation and dehydrogenative silylation catalysts
Nanoparticles that can be used as hydrosilylation and dehydrogenative silylation catalysts. The nanoparticles have at least one transition metal with an oxidation state of 0, chosen from the metals of columns 8, 9 and 10 of the periodic table, and at least one carbonyl ligand, preferably a silicide.
US11633727B2 Supported hydrotreating catalysts having enhanced activity
This invention provides supported catalysts comprising a carrier, phosphorus, at least one Group VI metal, at least one Group VIII metal, and a polymer. In the supported catalyst, the molar ratio of phosphorus to Group VI metal is about 1:1.5 to less than about 1:12, the molar ratio of the Group VI metal to the Group VIII metal is about 1:1 to about 5:1, and the polymer has a carbon backbone and comprises an amido group. Also provided are a process for preparing such supported catalysts, as well as methods for hydrotreating, hydrodenitrogenation, and/or hydrodesulfurization, using supported catalysts.
US11633726B2 Zeolite with reduced extra-framework aluminum
The present disclosure generally provides a catalyst composition comprising a zeolite containing iron and/or copper with a reduced amount of extra-framework aluminum. The catalyst composition is useful to catalyze the reduction of nitrogen oxides in exhaust gas in the presence of a reductant.
US11633712B2 Methods of treating metal carbonate salts
A method of treating a metal carbonate salt includes hydrolyzing a metal halide salt to form a hydrohalic acid and a hydroxide salt of the metal in the metal halide salt. The metal includes an alkaline earth metal or an alkali metal. The method includes reacting the hydrohalic acid with the metal carbonate salt, wherein the metal carbonate salt is a carbonate salt of the alkaline earth metal or alkali metal, to form CO2 and the metal halide salt. At least some of the metal halide salt formed from the reacting of the hydrohalic acid with the metal carbonate salt is recycled as at least some of the metal halide salt in the hydrolyzing of the metal halide salt to form the hydrohalic acid and the hydroxide salt.
US11633710B2 Systems and methods for processing gases
The invention includes a gas processing system for transforming a hydrocarbon-containing inflow gas into outflow gas products, where the system includes a gas delivery subsystem, a plasma reaction chamber, and a microwave subsystem, with the gas delivery subsystem in fluid communication with the plasma reaction chamber, so that the gas delivery subsystem directs the hydrocarbon-containing inflow gas into the plasma reaction chamber, and the microwave subsystem directs microwave energy into the plasma reaction chamber to energize the hydrocarbon-containing inflow gas, thereby forming a plasma in the plasma reaction chamber, which plasma effects the transformation of a hydrocarbon in the hydrocarbon-containing inflow gas into the outflow gas products, which comprise acetylene and hydrogen. The invention also includes methods for the use of this gas processing system.
US11633705B2 Agitators, storage vessel assemblies, and methods of agitating dry particulates within storage vessel assemblies
An agitator for disposition within a cavity of a vessel body containing a particulate includes a weighted portion and a stirring portion. The agitator is positioned and disposed relative to the vessel body to move the stirring portion through the particulate in response to movement of the weighted portion in response to gravitational and/or inertial forces acting on the weighted portion due to movement of the vessel body. Particulate storage vessel arrangements and methods of particulate mixing are also described.
US11633704B2 Rotation mixer with continuous belt drive
A rotation mixer including a housing, a drive unit coupled to the housing, a carriage mounted on the drive unit for rotation relative to the housing, and a basket mounted for rotation relative to the carriage. The basket receives material to be mixed. The carriage includes an arm and a drive line coupled to the arm. The arm is mounted on the drive unit for rotation about a first axis relative to the housing, and the drive line converts rotation of the arm into rotation of the basket about a second axis relative to the arm during use of the rotation mixer. The drive line illustratively includes a belt and plurality of pulleys upon which the belt travels in a continuous loop, the belt engaging with a gear on the basket to cause rotation of the basket.
US11633702B2 Solder paste on demand apparatus
A system and method are presented for producing solder paste having undercooled metallic core-shell particles. In one or more arrangements, the system includes a reconstitution assembly, a dispenser assembly, and a mixer, among other components. The reconstitution assembly is configured to place the cores of the solid core metallic core-shell particles into an undercooled liquid state to form a plurality of undercooled metallic core-shell particles. The dispenser assembly is configured to dispense one or more of a set of available flux components. The mixer assembly is configured to mix the one or more of the set of flux components dispensed by the dispenser assembly with the plurality of undercooled metallic core-shell particles formed by the reconstitution assembly to form a solder paste.
US11633701B2 Filter medium, method for manufacturing same, and filter unit comprising same
A filter medium according to one embodiment of the present invention comprises: a first support having a plurality of pores; a nanofiber web comprising nanofibers disposed on upper and lower portions of the first support and forming a three-dimensional network structure, and a hydrophilic coating layer formed on at least a part of an outer surface of the nanofibers, wherein the hydrophilic coating layer is formed of a hydrophilic coating composition comprising a hydrophilic polymer compound having at least one functional group selected from a hydroxyl group and a carboxyl group and a crosslinking agent comprising at least one sulfone group; and a second support having a plurality of pores interposed between the first support and the nanofiber web.
US11633700B2 Independent spacers and methods
Methods of making membrane elements for fluid or gas filtration, comprising applying feed or reject spacers, or intermediate spacers, or fold line protection strips, or end support strips directly to a membrane sheet, or to a substrate material which are subsequently applied to a membrane sheet, which thereby avoids contamination from directly printed adhesives, inks, or polymers, or damage from heat or radiation damage to the membrane sheet during direct application of spacers or patterns to the surface of the membrane sheet, thereby avoiding utilization of conventional feed spacer mesh materials. Membrane sheets and spiral wound filtration elements having spacers applied to defined regions of the sheet, in some embodiments having spacers mounted on substrates with different material properties, e.g., stiffness, than the underlying membrane.
US11633698B2 Method and apparatus for the filtration of biological solutions
A system, method and device are disclosed for bio-processing a feed stream and providing a constant output by operating a continuous single-pass tangential-flow process. The single-pass process provides high conversion concentration while operating at relatively low feed flow rates, and the process can also be used to provide constant output diafiltration.
US11633695B1 Device and method of simultaneously removing flammable gases and nitrous oxide
A device and method of simultaneously removing flammable gases and nitrous oxide are provided. The device includes a thermal oxidation chamber, a high-temperature resistant dust filter, and a catalyst chamber. The thermal oxidation chamber is configured to receive an exhaust gas from a process tool. The exhaust gas includes flammable gases and nitrous oxide. The thermal oxidation chamber has a first exhaust pipe to emit nitrous oxide and dust generated after the exhaust gas is thermally oxidized. The high-temperature resistant dust filter receives dust and nitrous oxide from the first exhaust pipe, wherein the high-temperature resistant dust filter has a filter fiber net and a second exhaust pipe, and the second exhaust pipe is configured to emit nitrous oxide. The catalyst chamber receives nitrous oxide from the second exhaust pipe, wherein the catalyst chamber has a nitrous oxide decomposition catalyst to decompose nitrous oxide into nitrogen and oxygen.
US11633694B2 Heat exchange device and freeze dryer
A heat exchange device and a freeze dryer. The freeze dryer comprises a bearing device, and an evaporation device and a condensation device which are provided on the bearing device, at least one of the evaporation device and the condensation device comprising a structure of the heat exchange device. The heat exchange device is integrally molded by extrusion, and the heat exchange device is provided with at least one medium flow passage, a plurality of fins are formed on the outer periphery of the medium flow passage, and the fins being provided at intervals to form gaps allowing airflows to pass therethrough. The heat exchange device and the freeze dryer of the present disclosure can be designed to be smaller, reducing the volume, and facilitating miniaturization of products.
US11633688B2 HEPA air filtration with an air handling device
A HEPA/VOC air handling system having a HEPA air filtration unit, an air handling unit, a fresh air sensor system, a return air sensor system, an air handling air sensor, and a controller.
US11633687B2 Air purifier
An air purifier including a fan having a plurality of fan speeds; a filter, wherein the fan draws air through the filter; a user interface in communication with a control system; wherein upon activation of the control system, the control system identifies an initial air quality index (AQI) based upon a geographic location of the air purifier, a room size based upon the type of room in which the air purifier is placed, and identifies a fan speed set by a user through the user interface, and determines a target air quality index achievable in thirty minutes of fan operation is provided. Further provided is an air purifier capable of predicting and updating time to achieve a target air quality and a target air quality based on a number of environmental factors.
US11633686B2 Round filter element, in particular for gas filtration
A round filter element has a filter medium body with a wall to be flowed through by a fluid to be purified in a radial direction relative to a longitudinal axis of the filter medium body. A circumferentially extending seal carrier is arranged at or adjacent to an end face of the filter medium body. A sealing element is supported at the seal carrier adjacent to a radial outer side of the filter medium body. A positioning element extends into the filter medium body and engages with a correlated housing-associated counter positioning element of a filter housing when the round filter element is installed in the filter housing. The seal carrier separates flow-tightly a raw side of the round filter element from a clean side of the round filter element when the round filter element is installed in the filter housing.
US11633685B2 Adjustable abrasive and dust separator
Provided is a centrifuge media separator for separating blast particulate from fine particulate carried by air flowing from a blast cabinet and through the media separator. The centrifuge media separator comprises an upper panel, a lower panel, and an outer wall. The upper panel has a central opening formed therein. The outer wall is configured in a truncated logarithmic shape and which extends between the upper and lower panels. The outer wall has at least one particulate escape aperture formed therein. The upper panel, lower panel and outer wall collectively define a curvilinear air passageway having an inlet and an outlet. An air foil extends from the outer wall in to the air passageway. The distance than the air foil extends in to the air passageway is adjustable. The inlet is configured to allow a flow of air to enter the air passageway and circulate therethrough toward the outlet. The escape aperture is configured to exhaust the blast particulate out of the passageway. The central opening is configured to exhaust the fine particulate out of the passageway.
US11633683B2 Easy to service air filter
An air cleaner assembly includes a filter housing extending axially along a longitudinal axis and a cover. The filter housing includes at least one sidewall (e.g., an annular sidewall) extending between a first housing end and a second housing end and a retainer formed proximate at least one of the first housing end and the second housing end. The cover is removably coupled to at least one of the first housing end and the second housing. The cover includes a handle assembly having a latch configured to releasably engage the retainer of the filter housing. The filter element includes filter media and is axially insertable into the filter housing when the cover is removed from the filter housing.
US11633680B2 Bar screen filter apparatus and method
An apparatus for removing debris from water in a channel includes a bar screen assembly having a plurality of spaced apart, elongated filter bars arranged in a parallel relationship. A continuous conveyor carries a plurality of rakes. Each rake includes a plurality of spaced-apart tines interdigitated with the filter bars as the rake is moved along the filter bars by the conveyor to remove debris from the bar screen assembly. A conveyor belt retaining system includes at least one guide engaging an upstream side of an inner run of the conveyor and a counterweight connected to the at least one guide for biasing the inner run in a downstream direction.
US11633678B2 Liquid quality system with drag-inducing portions
The embodiments of the present disclosure provide a system for removing particulates from liquid. The system may comprise a base, a tubular body extending upwardly from the base, a liquid quality device located above the base, a sump region located between the base and the liquid quality device, and a plurality of drag-inducing portions positioned in the sump region and projecting inwardly toward a central axis of the sump region. The tubular body may comprise an inlet and an outlet. The plurality of drag-inducing portions may comprise a first set of drag-inducing portions, a second set of drag-inducing portions, a third set of drag-inducing portions, and a fourth set of drag-inducing portions. The first, second, third, and fourth sets of drag-inducing portions may be positioned equidistant from each other and at a same height around a perimeter of the sump region.
US11633676B2 Phase separation behavior modifying agents for aqueous two-phase separation within porous material
The present invention relates to a method and/or device for improving the separation behaviors and performance of aqueous two-phase system (ATPS) for the isolation and/or concentration of one or more target analytes from a sample. In one embodiment, the present method and device comprise ATPS components within a porous material and one or more phase separation behavior modifying agents that improve the separation behavior and performance characteristics of ATPS, including but not limited to the increasing the stability or reducing fluctuations of ATPS thought the adjustment of total volume of a sample solution that undergoes phase separation, volume ratio of the two phases of the ATPS, fluid flow rates, and concentrations of ATPS components.
US11633674B2 Toy construction element
A toy construction element is disclosed having a body with at least one projection extending therefrom and a plurality of complementary-shaped recesses formed therein. The recesses extend along at least two different axes and are configured for receiving a corresponding projection from like elements so as to allow like construction elements to be interconnected in three dimensions. The projections and/or recesses may be formed with snap-fit interlocking features whereby the element is configured for interlocking engagement with like elements. The snap-fit interlocking features can include complementary locking formations formed on each projection and each recess. The formations are configured to pass over each other as the projection of one element is received in the recess of another element when like elements are assembled, and the recess is at least in part defined by a resilient component that flexes to resist passage of the formations during assembly and disassembly.
US11633671B2 Method and apparatus for dynamic management of formations in a video game
A computer-implemented method, non-transitory computer-readable medium and apparatus for dynamic management of formations in a video game. The method includes maintaining a virtual three-dimensional environment and causing a plurality of video game characters to travel along a path in the virtual three-dimensional environment in a formation. The formation has a formation type and the formation type is a first formation type. The method also includes moving the formation along the path. The method also includes, responsive to determining a change in characteristics of the path at a point in the virtual three-dimensional environment that is ahead of the formation, changing the formation type to a second formation type in advance of the change in characteristics of the path.
US11633670B2 Information processing system, non-transitory computer-readable storage medium having stored therein information processing program, information processing apparatus, and information processing method
An example of an information processing system sets an image capturing direction of a virtual camera in accordance with an image capturing direction of a camera, and if the image capturing direction of the camera is within a predetermined range, moves a virtual door in a virtual space in accordance with the image capturing direction of the virtual camera. If the image capturing direction of the camera is directed more upward than a first threshold, the information processing system does not move the virtual door further in the up direction. If the image capturing direction of the camera is directed more downward than a second threshold, the information processing system does not move the virtual door further in the down direction.
US11633669B2 Video modification and transmission
Methods and apparatus are disclosed for video transmission. In one example, computer-readable storage media store instructions cause a processor to: generate first motion data; distribute, toward terminal devices of a plurality of viewers via a communication line, the first motion data; receive a web page; receive first operation data from a user interface; generate a second video related to a computer-implemented game on the basis of the first operation data by using the received web page; distribute the second video toward the terminal devices of the plurality of viewer; receive viewer data regarding a plurality of viewers; extract a selected game object out of a plurality of game objects to be used in the game; calculate a control parameter related to the selected game object on the basis of the viewer data; generate the second video including the selected game object; and distribute the second video toward the terminal devices.
US11633668B2 Eye contact prompting communication device
A communication device, method, and computer program product prompt correct face/eye positioning to enable perceived eye-to-eye contact of a user of a video capturing device with camera on a same device side as the viewable display device. A first communication device includes a first display device having a first graphical user interface (GUI). A first image capturing device of the first communication device has a field of view that captures a face of a first user viewing the first GUI. The first image capturing device generates a first image stream of the field of view. A controller of the communication device identifies a look target area of the first GUI proximate to the first image capturing device. The controller presents visual content on the first GUI within the look target area to prompt the first user viewing the first GUI to look towards the look target area.
US11633666B2 System, method and handheld controller for multi-player gaming
Embodiments of the invention relate to systems and methods for multi-player gaming. Some embodiments relate to systems having an improved communications infrastructure and improved handheld game controllers, while other embodiments relate to improvements in handling large numbers of players in the multi-player game when played in a game arena with a single large display screen showing the multi-player game images. In one particular embodiment, a system is provided that has a game server controlling a display system to display the multi-player game on the large screen and a plurality of game controllers. Each game controller has a secondary display means for providing a secondary game display and input means for receiving player input. The system further comprises communication means for enabling communication between the game server and each of the plurality of game controllers. The plurality of game controllers are located in proximity to the large display screen such that it is visible to game players manipulating the game controllers while playing the multi-player game.
US11633653B2 Illuminated hockey puck assembly
An illuminated hockey puck assembly includes a housing having an outer surface including a top side, a bottom side, and a perimeter edge extending between the top and bottom sides. The illuminated hockey puck assembly has a weight, a shape, and a size comparable to a hockey puck. A lighting system is mounted within the interior and is encapsulated by the outer surface such that the lighting system is immobilized in the housing. The housing is translucent such that the housing is illuminated by the lighting system when the lighting system emits lights.
US11633652B2 Bat with barrel pivot joint
A ball bat configured for impacting a ball. The ball bat extends along a longitudinal axis and includes a bat frame and a pivot joint. The bat frame includes a handle portion coupled to a barrel portion. The barrel portions has a distal region. The pivot joint is coupled to the distal region of the barrel portion. The pivot joint movably supports the barrel portion relative to the longitudinal axis such that the distal region of the barrel portion may pivot towards and away from the longitudinal axis about the pivot joint.
US11633646B2 Oscillating positive expiratory pressure device
A respiratory treatment device includes a housing, an inlet configured to receive air into the housing, an outlet configured to permit air to exit the housing, and a flow path defined between the inlet and the outlet. A restrictor member positioned along the flow path that is configured to move between a closed position, where the flow of air along the flow path is restricted, and an open position, where the flow of air along the flow path is less restricted. A vane in communication with the flow path rotatable in response to the flow of air along the flow path is configured to move the restrictor member between the closed position and the open position. A protrusion extends in to the housing to limit movement of the restrictor member from the closed position to the open position.
US11633640B2 Exercise machine tension device securing system
An exercise machine tension device securing system for safely and efficiently securing selectable biasing members to an exercise machine. The exercise machine tension device securing system generally includes an exercise machine including a frame and a carriage movably positioned on the frame. A plurality of tension devices may be connected to the frame at one end; with the other end being removably connected to the carriage by a selection device. The selection device may include a plurality of slots for removably receiving one or more of the tension devices to secure the tension devices selectively to the carriage. A securing member movably connected to the selection device includes projections adapted to selectively enclose the slots so as to secure the tension devices within the slots of the selection device.
US11633636B2 Wireless neighborhood wildfire defense system network supporting proactive protection of life and property in a neighborhood through GPS-tracking and mapping of environmentally-clean anti-fire (AF) chemical liquid spray applied to the property before wild fires reach the neighborhood
A wireless wild fire defense system network supporting proactive protection of life and property in GPS-specified neighborhoods using GPS-managed delivery of environmentally-clean anti-fire (AF) chemical liquid spray to property before wild fire reaches the neighborhoods. The wireless system network includes a GPS system for providing GPS-location services to each system components in the wireless system network. A wireless communication network supports one or more network databases accessible by systems and devices deployed on the wireless communication network. A fleet of mobile GPS-tracked anti-fire liquid spraying systems are assigned to GPS-specified neighborhoods for spraying anti-fire chemical liquid on combustible property, buildings, and ground cover to inhibit fire ignition and flame spread wherever the anti-fire chemical liquid is sprayed. When allowed to dry, the anti-fire chemical liquid provides fire-protection status to sprayed property that is GPS-tracked and mapped within a network database maintained on the wireless communication network, recording wherever the environmentally-safe anti-fire chemical liquid has been spray applied. The system network includes mobile computing systems, each running a mobile application and deployed to a property owner, spray contractor or other stakeholder, such as firefighters and property insurance inspectors, for remotely monitoring the fire-protection status of property in any GPS-specified neighborhood, at any time on any specified date, along with the status of active wild fires surrounding the neighborhood. A command center deployed on the wireless system network transmits wild fire alerts and notifications and property spray orders, and supports microservices configured for monitoring and managing GPS-tracked spraying operations within GPS-specified neighborhoods. Through GPS-managed delivery of anti-fire chemical liquid spray on property surfaces before arrival of wild fire, fire ignition and flame spread are inhibited, and human and animal life and property are protected.
US11633634B2 Cut-resistant leading edge fall arrest system and method
A fall arrest system includes a line retraction device having a safety line, an energy absorber configured for connecting to a terminal end of the safety line, and a harness configured for connecting to the energy absorber such that the energy absorber is disposed between the terminal end of the safety line and the harness. The safety line is selected to have a predetermined mean breaking force with a first standard deviation, and the energy absorber is selected to have a predetermined mean deployment force with a second standard deviation. The mean breaking force of the safety line and the mean deployment force of the energy absorber overlap over an overlapping region of the first and second standard deviation. A ratio of an overlap mean force of the overlapping region to an overlap standard deviation of the overlapping region is less than or equal to 6.
US11633631B1 Activation assembly with shape memory alloy (SMA) for a sealed container
An activation assembly for a sealed container includes a striker, a detent, and a shape memory alloy (SMA) wire connected to the detent. The SMA wire may move the detent from a first position to a second position relative to the striker based on activation of the SMA wire where, in the first position, the detent is engaged with the striker, and, in the second position, the detent is disengaged from the striker and the striker is movable from a stowed position to a deployed position.
US11633630B2 Noninvasive tissue displacement control and monitoring for neuromodulation
The subject matter of the present disclosure generally relates to techniques for neuromodulation that include applying energy (e.g., ultrasound energy) into an internal tissue to cause tissue displacement and identifying that the tissue displacement has occurred. In one embodiment, the presence of tissue displacement is associated with a desired therapeutic or physiological outcome, such as a change in a molecule of interest.
US11633629B2 Method of calibration of a stereoscopic camera system for use with a radio therapy treatment apparatus
The disclosed calibration method includes a calibration phantom positioned on an adjustable table on the surface of a mechanical couch, with the phantom's centre at an estimated location for the iso-centre of a radio therapy treatment apparatus. The calibration phantom is then irradiated using the apparatus, and the relative location of the center of the calibration phantom and the iso-centre of the apparatus is determined by analyzing images of the irradiation of the calibration phantom. The calibration phantom is then repositioned by the mechanical couch applying an offset corresponding to the determined relative location of the centre of the calibration phantom and the iso-centre of the apparatus to the calibration phantom. Images of the relocated calibration phantom are obtained, to which the offset has been applied, and the obtained images are processed to set the co-ordinate system of a stereoscopic camera system relative to the iso-centre of the apparatus.
US11633628B2 Monitor for high dose rate electron therapy, system and method
A radiotherapy dose rate monitor system includes an electrode configured to be impinged by radiotherapy radiation, and a current measurement circuit configured to measure a current through the electrode. An emission of secondary electrons emitted from the electrode provides a majority of current through the electrode.
US11633618B2 Muscle optimization device and method
A system, device and method are provided for exposing a patient to therapeutic resonant frequency patterns (RFP) for therapy and treatment of a patient, for example, biological tissue such as muscle, tendon, ligament, and nerve tissue. The resonance frequencies originate from many bioactive substances, pharmaceuticals or other compounds, and key frequencies of the RFP of a compound can be replicated and then delivered to a patient using an electromagnetic catalyst to provide therapeutic benefits. RFPs can be imprinted in a separate device using a plasma imprinting device and method. This separate device can be actively excited by a delivery mechanism that uses electromagnetic or mechanical waves to interact with the device. The actively excited device transmits the RFPs or therapeutic resonant frequency patterns to the patient for similar enhancements and therapeutic benefits.
US11633617B2 Device and method for generating a plasma jet
The invention relates to a device (10) for generating a plasma jet (P) comprising a first conduit (11) inside a second conduit (12), a first electrode (17) and a second electrode (18) for generating an electric field in a feed gas flow (F) provided in a first flow channel (15) to generate a plasma jet (P), and adapted to provide a curtain gas flow (C) in the space between the first and second conduit (11,12), wherein the first electrode (17) is positioned radially outside of the first flow channel (15), and wherein the radial distance of the second electrode (18) from a longitudinal axis (I) is larger than the radial distance of the first electrode (17) from said longitudinal axis (1).The invention further relates to an endoscope comprising a device (10), a method for generating a plasma jet (P), a method and a use of the device (10) for manipulating a cavity.
US11633614B2 Wearable cardiac device to monitor physiological response to activity
A patient-worn ambulatory cardiac monitoring device for monitoring a patient during a patient activity includes at least one physiological sensor configured to detect signals indicative of cardiac activity, an activity sensor and associated circuitry configured to monitor patient movements, and a vibrational sensor configured to monitor a cardio-vibrational signal of the patient. The at least one physiological sensor can include one of an ECG sensor and a heart rate sensor. At least one processor in communication with the at least one physiological sensor, the activity sensor, and the vibrational sensor, is configured to measure, during the patient activity, at least one time interval between an ECG fiducial point in an ECG signal and a cardio-vibrational fiducial point in the cardio-vibrational signal during a cardiac cycle of the patient's heart.
US11633610B2 Mitigating false messages and effects thereof in multi-chamber leadless pacemaker systems and other IMD systems
Implantable medical devices (IMDs) described herein, and methods for use therewith described herein, reduce how often an IMD accepts a false message and/or reduce adverse effects of an IMD accepting a false message. Such IMDs can be leadless pacemakers (LPs), or implantable cardio defibrillators (ICDs), but are not limited thereto. Such embodiments can be used help multiple IMDs (e.g., multiple LPs) implanted within a same patient maintain synchronous operation, such as synchronous multi-chamber pacing.
US11633609B2 System and methods for establishing a communication session between an implantable medical device and an external device
A method is provided for establishing a communication session with an implantable medical device (“IMD”). The method includes configuring an IMD and an external device to communicate with one another through a protocol that utilizes a dedicated advertisement channel. The advertisement period and the scan period of the protocol are independent of one another such that the advertisement and scan periods at least partially overlap intermittently after a number of cycles. When the external device detects one of the advertisement notices, the method includes establishing a communications link between the external device and the IMD.
US11633608B2 Point-and-click programming for deep brain stimulation using real-time monopolar review trendlines
A system and method for selecting leadwire stimulation parameters includes a processor iteratively performing, for each of a plurality of values for a particular stimulation parameter, each value corresponding to a respective current field: (a) shifting the current field longitudinally and/or rotationally to a respective plurality of locations about the leadwire; and (b) for each of the respective plurality of locations, obtaining clinical effect information regarding a respective stimulation of the patient tissue produced by the respective current field at the respective location; and displaying a graph plotting the clinical effect information against values for the particular stimulation parameter and locations about the leadwire, and/or based on the obtained clinical effect information, identifying an optimal combination of a selected value for the particular stimulation parameter and selected location about the leadwire at which to perform a stimulation using the selected value.
US11633607B2 AV synchronous septal pacing
An implantable medical system may provide atrioventricular synchronous pacing using the ventricular septal wall. The system may include a ventricular electrode coupled to an intracardiac housing or a first medical lead implantable in the ventricular septal wall of the patient's heart to deliver cardiac therapy to or sense electrical activity of the left ventricle of the patient's heart and a right atrial electrode coupled to a leadlet or second medical lead to deliver cardiac therapy to or sense electrical activity of the right atrium of the patient's heart. A right ventricular electrode may be coupled to the intracardiac housing or the first medical lead and implantable in the ventricular septal wall of the patient's heart to deliver cardiac therapy to or sense electrical activity of the right ventricle of the patient's heart.
US11633604B2 Efficient use of an implantable pulse generator battery, and associated systems and methods
Systems and methods for the efficient use of an implantable pulse generator (IPG) battery are disclosed. A representative system for adjusting an electrical signal of an IPG associated with delivering therapy to a patient comprises a computer readable medium having instructions that cause the IPG to deliver a supply voltage at a first value, adjust the supply voltage from the first value until a threshold break occurs, and, based at least in part of the threshold break, increase the supply voltage from the second value to a third value. As therapy is delivered to the patient, the system iteratively adjusts the supply voltage to approach and reflect a variable minimum voltage needed to provide the requested current to the IPG.
US11633597B2 Contingent cardio-protection for epilepsy patients
Disclosed are methods and systems for treating epilepsy by stimulating a main trunk of a vagus nerve, or a left vagus nerve, when the patient has had no seizure or a seizure that is not characterized by cardiac changes such as an increase in heart rate, and stimulating a cardiac branch of a vagus nerve, or a right vagus nerve, when the patient has had a seizure characterized by cardiac changes such as a heart rate increase.
US11633594B2 Electrotherapy and neurostimulation medical device apparatus and method
A method and apparatus are disclosed for providing therapeutic electric current to a treatment site of a patient. The steps of the method comprise generating a first and second signal having a frequency difference between 1 Hz and 300 Hz, wherein each signal has a frequency of at least 1 KHz and are amplified by Class D switching amplifiers, minimizing the DC component of the first and second signals using balanced amplifiers; operatively coupling a first electrode of at least one pair of electrodes to a patient's body on or beneath a first epidermal or mucous membrane surface; operatively coupling a second electrode of at least one pair of electrodes to a patient's body on or beneath a second epidermal or mucous membrane surface; forming a therapeutic signal configured to reduce pain at a treatment site by simultaneously sending a first signal from the first electrode to the second electrode and sending a second signal from a second electrode to the first electrode, and then simultaneously sending the first signal from the second electrode back to the first electrode and the second signal from the first electrode back to the second electrode, wherein the first and second signals are linearly independent off phase alternating current signals; and adjusting the therapeutic signal utilizing a feedback system based on impedance changes within the patient's body.
US11633593B2 Treatment of pelvic floor disorders using targeted lower limb nerve stimulation
Methods and systems for improving nerve stimulation are disclosed which relate to shaping characteristics of the stimulation field such as by using different geometries and locations of stimulation. In embodiments, systems and methods are provided to improve selective modulation of specific targeted neural substrate, while minimizing the activation of adjacent non-targeted nervous tissue. While aspects of the disclosed technologies can be applied to any part of the central and peripheral nervous systems for treatment various disorders and providing symptom relief to provide for therapy related to pelvic floor disorders such as overactive bladder.
US11633591B2 Combination implant system with removable earplug sensor and implanted battery
Cochlear implant systems can comprise an implantable subsystem comprising a cochlear electrode, a stimulator, a battery, and a first near field communication interface positioned subcutaneously proximate an ear canal. Cochlear implant systems can further comprise a removable earplug comprising a sensor, a second near field communication interface, and a signal processor. The removable earplug can be inserted into an ear canal to align the first and second near field communication interfaces. Once aligned, the battery can provide electrical power to the removable earplug via the near field communication interfaces. The signal processor can receive input signals from the sensor of the removable earplug and generate a stimulation signal representative of the auditory signals. The signal processor can communicate the stimulation signal to the stimulator via the near field communication interfaces.
US11633588B2 Earset assembly for providing iontophoresis including valve
Systems, apparatus, and methods are described for delivering a therapeutic substance, such as an anesthetic, to a tympanic membrane of a subject. Such systems can include an earset with a valve configured to control flow of a fluid, such as air, into and out of a reservoir. In some embodiments, systems, apparatus, and methods described herein can include additional valves and features for relieving negative pressure within the reservoir.
US11633587B2 Mixed ionic electronic conductors: devices, systems and methods of use
The invention provides a variety of novel devices, systems, and methods of utilizing mixed-ionic-electronic conductor (MIEC) materials adapted to function with an applied current or potential. The materials, as part of a circuit, are placed in contact with a part of a human or nonhuman animal body. A sodium selective membrane system utilizing the MIEC is also described.
US11633583B2 Implantable interface device
An interface device for implantation in a subject includes a tissue integration layer and a crowning element. The tissue integration layer has a porous structure adapted for ingress of tissue to anchor the device when implanted. The crowning element is adapted for epidermal attachment when the device is implanted and is configured such that once implanted, part of the crowning element extends through the epidermis and is accessible from outside the subject's body. The porous structure of the tissue integration layer is interconnected for tissue ingress during implantation.
US11633580B2 Applicator for water-soluble sheet-shaped preparation
A nozzle having at least one hole on an end portion having a plane with a size capable of holding a sheet-like water-soluble preparation. The nozzle also has concave-convex portions on a portion of the plane excluding the hole. An applicator for a sheet-like water-soluble preparation, which is composed of a liquid container and the nozzle.
US11633579B2 Dilator with slit and slidable sleeve
The invention includes a dilator comprising a tube and an elastic, unitary sleeve that is slidable both longitudinally and transversely to the cylindrical barrel when disposed on the tube.
US11633576B2 Multi-purpose balloon catheter for intra cavity radiation delivery
A multi-purpose balloon intra-cavity catheter includes a catheter having a proximal end portion, a central portion and a non-branching distal end portion, a plurality of lumens associated with the catheter extending from the proximal end portion, and a plurality of inflatable balloons positioned in the central portion and/or the non-branching distal end portion. Each of the plurality of inflatable balloons is communicatively associated with a corresponding one of the plurality of lumens, the plurality of inflatable balloons being selectively inflated or deflated to position and stabilize the catheter in a cavity for delivery of a medical treatment. The catheter can include an extraction opening associated with a lumen to remove fluids and materials from the cavity, and a connector associated with a corresponding lumen adapted to selectively receive one or more of a fluid medium or a radioactive isotope provided to a corresponding lumen for delivery of the medical treatment.
US11633575B2 Percutaneous device exchange
An apparatus includes a hemostasis valve; a base having a clamp releasably coupling a catheter to the base; a base drive member moving the base relative to the hemostasis valve along a first path; and a mechanism maintaining the position of an elongated medical device relative to the hemostasis valve while the catheter is being moved along the first path.
US11633573B2 Medical device securement system
A catheter securement device holds a medical article such as a catheter in position upon the body of a patient and at least inhibits longitudinal movement of the medical article. The securement device includes a retainer and a clamp. The retainer and clamp can include interengaging structure that can include a ratchet mechanism that allows a single securement system to be used with medical articles that have different longitudinal lengths as well as medical articles that have distally located contact surfaces.
US11633570B2 Rapid aspiration thrombectomy system and method
An intravascular access system for facilitation of intraluminal medical procedures within the neurovasculature through an access sheath. The system includes an aspiration or support catheter having a flexible, distal luminal portion having an inner diameter defining a lumen extending between a proximal opening at a proximal end of the luminal portion and a distal opening at a distal end of the luminal portion. The catheter has a rigid spine coupled to at least the proximal end of the luminal portion and extending proximally therefrom. The system includes a dilator having a flexible, distal dilator portion sized to be received within the lumen of the luminal portion. Associated systems, devices, and methods of use are also described.
US11633568B2 Obturator assembly with selectively controllable fluid flow path
An obturator assembly includes an obturator positionable within a lumen of a device and movable within the lumen between a first position and a second position. The obturator includes a distal tip portion, wherein, with the obturator in the first position, the distal tip portion limits fluid communication through the lumen and, with the obturator in the second position, the distal tip portion provides fluid communication through the lumen.
US11633564B2 Cushion to frame assembly mechanism
A full-face mask assembly includes a frame and a cushion provided to the frame. The cushion is adapted to form a seal around the patient's nose and mouth. A flexible lip is provided to an interior wall of the cushion. The flexible lip is adapted to engage the frame to provide a seal in use.
US11633561B2 Adjustable headgear that is easy to don and doff
A patient interface includes a plenum chamber, a seal-forming structure, and a positioning and stabilising structure to provide a force to hold the seal-forming structure in a therapeutically effective position on a patient's head. The positioning and stabilizing structure includes a superior strap portion, an inferior strap portion, and a posterior connecting strap portion connected to or formed integrally with the superior strap portion and the inferior strap portion. The posterior connecting strap portion is constructed from a mesh material that is different than the material used to construct the superior strap portion and the inferior strap portion. The posterior connecting strap portion has a greater stretch capability than the superior strap portion and a lesser stretch capability than the inferior strap portion. The stretch capabilities allow the positioning and stabilizing structure to be removable from the patient's head when the loop engages the connection portion.
US11633555B2 Non-combustion type flavor inhaler and aerosol delivery method
A non-combustion type flavor inhaler comprising: an atomizer atomizing an aerosol source without burning; and a controller controlling a power output to the atomizer, wherein the controller is configured to start supply of a power output to the atomizer before start of a user's puffing action, and is configured to stop supply of a power output to the atomizer during a user's puffing action.
US11633547B2 Protection device for a needle
The invention relates to a protection device (1) for a needle (203) of a tip (201) of a drug delivery device (202), comprising: —fixing means (2) for fixing the protection device to said tip, —protective legs (4) capable of transitioning from a first configuration ration in which they cover the needle, to a second configuration in which the needle is exposed, and to a third configuration in which they cover the needle, via pivot links, —removable maintaining means for maintaining the protective legs in their first configuration, —retaining means (9, 10) for retaining the protective legs in their third configuration, said pivot links comprising elastic return means (5) for automatically transitioning the protective legs from their first configuration to their second configuration. The invention also relates to an assembly comprising a drug delivery device and said protection device, and to a method for manufacturing said protection device.
US11633536B2 Advance diagnosis of operating mode viability
Techniques related to advance diagnosis of operating mode viability are disclosed. The techniques may involve obtaining status information pertaining to operation of a fluid delivery device. The status information may include at least one of a group comprising recent sensor measurement data, sensor calibration data, blood glucose reference measurement data, fluid delivery data, a current battery level of the fluid delivery device, and a current amount of fluid remaining in the fluid delivery device. The techniques may further involve determining, based on the status information, viability of transitioning to a destination operating mode of the fluid delivery device. Additionally, the techniques may involve causing generation of one or more user notifications of recommended remedial actions to improve the viability of transitioning to the destination operating mode when transitioning into the destination operating mode is determined not to be viable.
US11633535B2 Ambulatory device and components thereof
Certain embodiments provide multi-medicament or single medicament infusion systems for preventing the cross-channeling or improper delivery of medicaments. The system may include one or more of an infusion pump, medicament cartridges, cartridge connectors, a multi-channel fluid conduit, and an infusion set. The medicament cartridges may be sized and shaped differently such that the medicament reservoirs can only be inserted into the pump under selected configurations.
US11633534B2 Angiogram injections using electrocardiographic synchronization
An injection system is described that receives, from one or more sensors, a first group of one or more signals indicating a current volume of injection fluid dispensed from a fluid reservoir at a first time. The injection system determines, based on the first group of one or more signals, that a difference between a dispensed volume limit and the current volume of the injection fluid dispensed from the fluid reservoir at the first time is less than a necessary volume of fluid required to complete both a systolic injection phase and a diastolic injection phase. The injection system further, responsive to determining that the difference is less than the necessary volume of fluid required to complete both the systolic injection phase and the diastolic injection phase, controls the injection system to refrain from performing each of the systolic injection phase and the diastolic injection phase.
US11633533B2 Control architecture for reduced pressure wound therapy apparatus
Embodiments of a reduced pressure system and methods for operating the system are disclosed. In some embodiments, the system can include one or more processors responsible for various functions associated with various levels of responsiveness, such as interfacing with a user, controlling a vacuum pump, providing network connectivity, etc. The system can present GUI screens for controlling and monitoring its operation. The system can determine and monitor flow of fluid in the system by utilizing one or more of the following: monitoring the speed of a pump motor, monitoring flow of fluid in a portion of a fluid flow path by using a calibrated fluid flow restrictor, and monitoring one or more characteristics of the pressure pulses. The system can provide external connectivity for accomplishing various activities, such as location tracking of the system, compliance monitoring, tracking of operational data, remote selection and adjustment of therapy settings, etc.
US11633532B2 Device for promoting wound healing by high polymer low temperature ionized gas
A device has a power source having a high voltage terminal and a low voltage terminal, an oil-free gas compressor, a first molecular sieve, multiple ionized gas generators, an outer metal pipe, an inner metal pipe, a dielectric insulating ceramic sheet, and a gas outlet pipe. The first molecular sieve is connected between the oil-free gas compressor and the ionized gas generators, and is capable of filtering out molecules in the gas except for oxygen. The outer metal pipe and the inner metal pipe are electrically connected to the low voltage terminal and the high voltage terminal respectively. The dielectric insulating ceramic sheet is mounted between the outer metal pipe and the inner metal pipe, and forms an ionizing space, which communicates with the ionizing space, with the outer metal pipe.
US11633531B2 Phacoemulsification surgical multi-use pack usage tracker system
A surgical cassette/pack usage tracker for tracking a number of uses for a cassette/pack to prohibit uses from exceeding a maximum amount. A usage tracker system engages with or scans a portion of the cassette/pack to determine the number of uses. In illustrative embodiments, an implement interacts with a film in the cassette after each use and determines remaining uses for the cassette/pack. In other embodiments, an implement interacts with a rotatable wheel that rotates with each use, the implement configured to permit the tracker to identify the number uses and determine remaining uses for the cassette/pack. When a maximum usage amount is reached, the tracker system may issue a warning, eject or reject the cassette/pack and/or disable the surgical device from further use.
US11633529B2 Blood filtration systems
A blood filtration system can reduce the amount of plasma constituents (e.g., water and/or electrolytes) in the blood of the patient, and accordingly increase the hematocrit value of the patient. The blood filtration system (e.g., a controller, or the like) can determine a hematocrit value of a patient. The blood filtration system can determine a venous pressure of vasculature of a patient. The blood filtration system can compensate for pressure head in a component of a blood circuit (e.g., a withdrawal line of a catheter), for example to improve the accuracy of the venous pressure determination. The blood filtration system can determine one or more resistance characteristics of a blood circuit for the blood filtration system. The resistance characteristics can correspond to a resistance to a flow of blood through a component of the blood circuit.
US11633528B2 Apparatus for removing chemotherapy compounds from blood
A filter apparatus for removing small molecule chemotherapy agents from blood is provided. The filter apparatus comprises a housing with an extraction media comprised of polymer coated carbon cores. Also provided are methods of treating a subject with cancer of an organ or region comprising administering a chemotherapeutic agent to the organ or region, collecting blood laded with chemotherapeutic agent from the isolated organ, filtering the blood laden with chemotherapeutic agent to reduce the chemotherapeutic agent in the blood and returning the blood to the subject.
US11633524B2 Systems and methods for monitoring a fluid procedure using hydrostatic pressure
A computer-implemented method comprises providing a fluid circuit comprising fluid pathways configured to mount and associate with a durable processing device comprising a pressure sensor in communication with a controller and a fluid pathway. A container is connected to the pressure sensor and may receive a volume of fluid. A change in pressure values between a first and second time is measured from when the volume of fluid is not in communication with the pressure sensor to when the volume of fluid is in communication with the pressure sensor, the volume of fluid within the container or a presence or absence of a fluid connection to the fluid pathway based on the change in pressure values is determined, and a response action is executed if the volume of fluid within the container is not within an authorized volume range for the time period, or if a fluid connection is unauthorized.
US11633515B2 Aroma diffusing device and method of controlling aroma diffusing device
To provide an aroma diffusing device and a method of controlling an aroma diffusing device that can enable a plurality of functions to be achieved by operation inputs to one operation input part.Provided is an aroma diffusing device including: a perfume holding part in which a perfume is held; an air blowing source configured to supply air to the perfume holding part; an aroma discharge part through which the air having passed through the perfume holding part is discharged; an operation input part on which an operation input for the air blowing source is performed by a user; and an air blowing source control part configured to control a supply state of the air on the basis of an operation input on the one operation input part.
US11633514B2 Microfluidic cartridge and microfluidic delivery device comprising the same
A microfluidic delivery device and method of dispensing a fluid composition from a microfluidic die are provided. The method includes generating air flow from a fan; directing a first portion of the air flow through a first air outlet in a housing; directing a second portion of the air flow through a second air outlet in the housing; jetting a fluid composition from a microfluidic die through a fluid orifice in the housing; directing the second portion of air flow adjacent to the microfluidic die and out the fluid outlet, wherein the first portion of the air flow directs the fluid composition jetted out of the fluid outlet into the air.
US11633503B2 Delivery of oligonucleotide-functionalized nanoparticles
The present invention relates to compositions and methods for delivering an oligonucleotide-functionalized nanoparticle.
US11633487B2 Prodrugs comprising an aminoalkyl glycine linker
The present invention relates to novel prodrugs of primary or secondary amine- or hydroxyl-comprising biologically active moieties and pharmaceutically acceptable salts thereof, prodrug reagents, pharmaceutical compositions comprising these prodrugs and the use of these prodrugs. A disclosed prodrug may include a biologically active moiety reversibly and covalently linked to a specialized protective group; the linker may be reversible (i.e., hydrolytically cleavable in the absence of enzymes under physiological conditions) and, upon cleavage, may release a drug in its unmodified, pharmacologically active form.
US11633483B2 Modulators of PCSK9 expression
The present embodiments provide methods, compounds, and compositions useful for inhibiting PCSK9 expression, which may be useful for treating, preventing, or ameliorating a disease associated with PCSK9.
US11633479B2 Biodegradable lipids for the delivery of active agents
The present invention relates to a cationic lipid having one or more biodegradable groups located in a lipidic moiety (e.g., a hydrophobic chain) of the cationic lipid. These cationic lipids may be incorporated into a lipid particle for delivering an active agent, such as a nucleic acid. The invention also relates to lipid particles comprising a neutral lipid, a lipid capable of reducing aggregation, a cationic lipid of the present invention, and optionally, a sterol. The lipid particle may further include a therapeutic agent such as a nucleic acid.
US11633474B2 Modular targeted therapeutic agents and methods of making same
Provided herein are methods for making targeted therapeutics. In several embodiments, the therapeutics are directed against soluble agents such as toxins, venoms, and/or other factors that alter physiological biopathways as well as methods of using such therapeutics to treat patients or patient populations to reduce, eliminate, or inactivate, detrimental soluble agents that such patients or patient populations have been exposed to. In several embodiments, the therapeutics are directed to patient-specific disease markers. In several embodiments, the methods comprise screening a library comprising proteins linked to their cognate mRNAs to identify mRNA-protein pairs that bind to the diseased cells, isolating one or more proteins from the identified mRNA-protein pairs, and conjugating the isolated protein(s) to a therapeutic agent.
US11633469B2 Reassortant influenza virus production method
Provided is a method of producing reassortant influenza virus containing an antigenic protein of the first influenza virus strain, the method including the following steps: 1) a step of irradiating the first influenza virus strain with ultraviolet light in such an irradiation dose that the first influenza virus strain has initial infection ability and loses or is reduced in virus growth potential; 2) a step of infecting a host with the first influenza virus strain and the second influenza virus strain; 3) a step of culturing the host infected with the first influenza virus strain and the second influenza virus strain, to obtain culture product; 4) a step of inactivating influenza virus strain having an antigenic protein of the second influenza virus strain in the culture product obtained in the step 3); and 5) a step of collecting reassortant influenza virus after the step 4).
US11633467B2 Immunogenic composition and vaccine for generating an immune response to norovirus
An immunogenic composition comprising at least one Norovirus antigen and at least one adjuvant which is at least one B subunit of an AB5 toxin such as cholera toxin subunit B (CTB) or the B subunit of heat-labile E. coli exotoxin LT (LTB).
US11633464B2 Cancer prevention and therapy by inhibiting soluble tumor necrosis factor
Methods are disclosed for inhibiting the development of a tumor in a subject. The methods include administering to a subject a therapeutically effective amount of a dominant negative tumor necrosis factor (DN-TNF)-α protein and/or a nucleic acid encoding the DN-TNF-α protein. The DN-TNF-α protein and/or a nucleic acid encoding the DN-TNF-α protein can be administered alone or in combination with other agents.
US11633462B2 Pharmaceutical composition comprising plasminogen and uses thereof
Pharmaceutical compositions comprising plasminogen or a biologically active variant thereof are disclosed. In an embodiment, the composition comprises a tonicity modifier, a bulking agent, and a stabilising agent and has a pH of about 3.0 to about 10.0. In another embodiment, the composition contains an amount of particles in suspension equal to or greater than 10 μm which is lower than 6000 particles per 100 ml, and preferably lower than 2000 particles per 100 ml. Uses of these compositions as a medicament is contemplated. Various therapeutic uses of these pharmaceutical compositions is also contemplated.
US11633460B2 Injectable solution at pH 7 comprising at least one basal insulin wherein the pI is comprised from 5.8 to 8.5 and a co-polyamino acid bearing carboxylate charges and hydrophobic radicals
A composition includes co-polyamino acid bearing carboxylate charges and at least one hydrophobic radical -Hy that are chosen among the co-polyamino acids according to formula XXXb: wherein, D represents, independently, either a group —CH2— (aspartic acid) or a group —CH2—CH2— (glutamic acid), X represents a cationic entity chosen from the group comprising alkali cations, Rb and R′b, identical or different, are either a hydrophobic radical -Hy, or a radical chosen from the group consisting of an H, a C2 to C10 linear acyl group, a C3 to C10 branched acyl group, a benzyl, a terminal “amino acid” unit and a pyroglutamate, at least one of Rb and R′b is a hydrophobic radical -Hy, n+m represents the degree of polymerization DP of the co-polyamino acid, namely the mean number of monomeric units per co-polyamino acid chain and 5≤n+m≤250.
US11633457B2 Pharmaceutical compositions comprising oncostatin m (OSM) antagonist derivatives and methods of use
A method of treating cancer or metastasis is provided involving administering at least one oncostatin M (OSM) antagonist to a subject, wherein the subject has been diagnosed with cancer. Administration of an OSM antagonist such as a small molecule pharmaceutical is provided as well as an anti-OSM antibody, an anti-OSM aptamer, and an OSM mRNA antagonist. The OSM antagonists were found to inhibit or prevent tumor cell detachment, progression, proliferation and metastasis in several cancer types.
US11633456B2 Compositions and methods for promoting hair growth
Compositions and methods for treating hair loss are provided. One embodiment provides a microneedle composition, which when administered to the skin of a subject promotes hair growth. The microneedle compositions include an effective amount of glucocorticoid-induced leucine zipper (GILZ) protein having an amino acid sequence that has 99 or 100% identity to SEQ ID NO: 1, or fragment thereof to promote hair growth when administered to the skin of the subject and a bioerodible, biodegradable, or biosorbable polymer, wherein the composition is formulated as bioerodible, biodegradable, or bioabsorbable microneedles. In one embodiment the GILZ protein or fragment thereof is conjugated to a cell penetrating peptide. The cell penetrating peptide can be TAT GRKKRRQRRRPQ (SEQ ID NO:4) or a variant thereof.
US11633453B2 Reconstitutable teverelix-TFA composition
The present invention relates to a reconstitutable teverelix-TFA composition having a predefined molar ratio of teverelix to trifluoroacetate which is below the molar ratio required for microcrystal formation. Said composition remains stable during storage e.g. at a temperature around 2-8° C. Upon reconstitution a fixed amount of trifluoroacetate can be added to said composition thereby effectively and simply achieving an exact and desired molar ratio in order to obtain a fluid, milky microcrystalline aqueous teverelix-TFA suspension.
US11633452B2 Compositions and methods for treating vaginal dryness
A method of treating vaginal dryness by administering a vaginal care composition, which includes an effective amount of a vaginal care agent, to vaginal tissue of a user experiencing vaginal dryness. The vaginal care agent may be selected to specifically treat symptoms of vaginal dryness exhibited by the introitus and/or labia, based on the transcriptomic data of skin cells obtained therefrom. In some instances, the vaginal care composition may be applied to introitus and/or labia with a suitable implement configured for such use.
US11633450B2 Treatment of HMGB1-mediated inflammation
Methods of treating HMGB1-mediated inflammation by administering a therapeutically effective amount of an MD2-antagonist to a subject in need thereof are described. The novel MD2 antagonist tetrapeptide P5779 is also described.
US11633441B2 Immuno-modulated replication-efficient vaccinia virus strain
The invention refers to new immuno-modulated replication-efficient Vaccinia virus strain (IOVA) and its derivatives for the use in medicine.
US11633436B2 Cholesterol reducing compositions and methods of use thereof
Microbes expressing cholesterol oxidoreductase (COR) proteins, methods of engineering the microbes expressing COR proteins, compositions and methods of using the microbes are provided.
US11633434B2 Topical kits and compositions and use thereof
Kits and composition comprising: (i) a thermo-responsive hydrogel characterized by a viscosity suitable for hardening after administration on a subject's skin; (ii) a bacterial growth medium; and optionally, (iii) a population of non-pathogenic viable bacteria, are provided. Methods for topically delivering a therapeutic or cosmeceutical agent such as for inhibiting or reducing growth of microorganisms on a subject's skin are further provided.
US11633430B2 Combined chimeric antigen receptor targeting CD19 and CD20 and application thereof
The present invention provides a combined chimeric antigen receptor targeting CD19 and CD20 and application thereof. Specifically, the present invention provides a combined chimeric antigen receptor targeting CD19 and CD20, which comprises a scFv targeting CD19 and CD20, a hinge region, a transmembrane region, and an intracellular signaling domain. The present invention provides a nucleic acid molecule encoding the chimeric antigen receptor and a corresponding expression vector, a CAR-T cell, and applications thereof. The experimental results show that the chimeric antigen receptor provided by the present invention shows extremely high killing ability against tumor cells. The chimeric antigen receptor of the present invention targets CD19 and/or CD20 positive cells and can be used to treat CD19 and/or CD20 positive B-cell lymphoma, leukemia and other diseases.
US11633427B2 Vaccine and uses thereof in cell therapy
The present disclosure relates to compositions and methods for enhancing T cell response in vivo. For example, a method of enhancing T cell response in a subject or treating a subject having cancer, the method comprising: administering an effective amount of a composition comprising modified cells to the subject having a form of cancer associated with or expressing an antigen, for example, a solid tumor antigen; and administering (1) a nucleic acid encoding the antigen, (2) additional modified cells comprising the nucleic acid or the antigen, or (3) microorganisms, for example cold viruses, comprising the nucleic acid or the antigen. In embodiments, the modified cells comprise mixed cells targeting a solid tumor antigen and a white blood cell (WBC) antigen. In embodiments, the modified cells comprise a dominant negative form of an immune checkpoint molecule (e.g., PD-1). In embodiments, the modified cells comprise an exogenous polynucleotide encoding a therapeutic agent, such as IL-12 and IFNγ.
US11633424B2 Cell protective methods and compositions
Chondroitin sulfate compounds comprising chondroitin sulfate backbone 19 mer, CS-A 19 mer, CS-C 19 mer, CS-E 19 mer, C8 backbone 13 mer, C8-A 13 mer, CS-C 13 mer, CS-E 13 mer and/or combinations thereof are provided. Methods of treating histone toxicity in a subject are provided, the methods including administering to a subject a chondroitin sulfate compound to treat the histone toxicity in the subject. Pharmaceutical compositions for use in treating histone toxicity and/or sepsis are provided. Methods of treating sepsis in a subject are provided, the methods including administering to a subject a chondroitin sulfate compound to treat the sepsis in the subject.
US11633422B2 Methods and compositions for attenuating anti-viral transfer vector immune responses
Provided herein are methods and related compositions for administering viral transfer vectors and antigen-presenting cell targeted immunosuppressants.
US11633407B2 Botanical extracts and compounds from Schinus plants and methods of use
This disclosure relates to extracts from the Anacardiaceae (cashew plant family) and compositions comprising compounds contained therein. In certain embodiments, the extracts are derived from the fruit of a Schinus plant. In certain embodiments, the disclosure relates to methods of treating or preventing bacterial infections, acne, and other related uses.
US11633406B2 Industrial process for the preparation of high purity estetrol
The invention relates to the preparation of estetrol of formula (I), derivatives thereof protected at positions 3,15α,16α,17β of general formula (III), and 3-hydroxy derivatives thereof protected at positions 15α,16α,17β of general formula (IV), and to the intermediates of general formulae (III) and (IV) applied in the process. Another aspect of the invention is the use of estetrol of formula (I) obtained by the process of the invention for the preparation of a pharmaceutical composition.
US11633404B2 Agent for promoting corneal endothelial cell adhesion
The invention provides an agent for promoting adhesion of a corneal endothelial cell, containing a Rho kinase inhibitor, as well as a culture medium for a corneal endothelial cell, a solution for preservation of cornea, and a method of producing a corneal endothelial preparation, which includes culturing the corneal endothelial cell using the aforementioned culture medium.
US11633402B2 RET inhibitor
A compound represented by the following general formula (I) [the symbol in the formula are as defined in the description], a salt thereof, or the like is a RET inhibitor or RET tyrosine kinase inhibitor that can he used as an agent for the prevention or treatment of disorders including cancers and cancer metastasis having mutations in RET.
US11633401B2 Combination therapy with MEK inhibitor and CDK4/6 inhibitor to treat pancreatic cancer
The present technology provides methods for treating pancreatic cancer using a MEK inhibitor and a CDK4/6 inhibitor. Also disclosed herein are methods for increasing patient responsiveness to chemotherapeutic and/or immunotherapeutic regimes for pancreatic cancer. Kits for use in practicing the methods are also provided.
US11633398B2 Amorphous solid dispersions of dasatinib and uses thereof
Amorphous solid dispersions and pharmaceutical compositions of the protein kinase inhibitor dasatinib. The pharmaceutical compositions may be used in methods of treating a proliferative disorder such as cancer, or in methods of delivering dasatinib to patients without regard to whether the patient is concurrently administered a gastric acid-reducing agent, or without regard to whether the patient has an elevated gastric pH. The compositions may be particularly suitable for patients afflicted by achlorhydria or hypochlorhydria, or Helicobacter pylori infection.
US11633395B2 Substituted pyrazolo[1,5-a]pyrazines as negative allosteric modulators of group II metabotropic glutamate receptor
Provided are a compound that is useful for the prevention of and/or as a treatment agent for a disease in which a group II mGlu receptor is involved; and a medical application of said compound. Provided is a compound represented by formula (I) or a pharmaceutically acceptable salt thereof.
US11633393B2 Tubulin binding compounds and therapeutic use thereof
Disclosed herein are compounds that can bind to tubulin and activate GEF-H1. Methods of using these compounds for treating cancer are also disclosed.
US11633392B2 Use of morphinan derivative for therapeutic treatment of opioid delta receptor agonist-related disease
The present invention relates to a pharmaceutical composition comprising a morphinan derivative that exhibits an opioid δ receptor agonist activity. By administering the pharmaceutical composition provided by the present invention, opioid δ receptor-related diseases (for example, headache) can be treated or prevented.
US11633390B2 5-HT2A agonists for use in treatment of depression
The present invention relates to agonists of the 5-HT2A serotonin receptors and their medical uses. In one aspect the invention relates to 5-HT2A agonists of formula (I). In second aspect, the invention relates to selective 5-HT2A agonists of formula (II). In another aspect, the invention relates to mixed 5-HT2A/5-HT2C agonists of formula (III). In yet another aspect, the invention relates to 5-HT2A agonists for use in the treatment of a depressive disorder, more particular a 5-HT2A agonist for the use in the treatment of treatment-resistant depression.
US11633382B2 Treatment of ER-negative breast cancer with an PDGF-CC inhibitor and anti-estrogen
The invention discloses that ER-negative breast cancers can be converted into ER positive breast cancers, such as to a breast cancer of luminal-like phenotype by treatment with anti-PDGF-CC antibodies. ER-positive breast cancers, including luminal-like breast cancers can be treated with anti-estrogen treatment. On this basis the invention discloses that surprisingly, ER-negative breast cancers can be treated with anti-estrogen treatment, if the treatment is combined with treatment with anti-PDGF-CC antibodies. Said treatment may for example be an adjuvant treatment, for example a treatment aiming at reducing the risk of relapse of a breast cancer after removal of the primary tumor by surgery.
US11633375B2 Method for treating infectious diseases with isothiocyanate functional compounds
A method for treating an infectious disease, including the step of administering an isothiocyanate functional surfactant to a patient having an infectious disease. In one embodiment, the protonated form of the isothiocyanate functional surfactant is represented by the following chemical structure:
US11633373B2 Method for reduction of behavioral disorders in pigs
The present invention relates to the use of guanidinoacetic acid and a method of treating caudophagia in pigs.
US11633367B2 Transdermal delivery system containing rotigotine
A transdermal therapeutic system containing rotigotine base in a self-adhesive layer structure. The system includes a backing layer, and a rotigotine-containing biphasic layer. The biphasic layer has an outer phase having a composition including 75% to 100% of a polymer or a polymer mixture, and an inner phase that forms dispersed deposits in the outer phase. The inner phase includes rotigotine base and a polymer mixture of at least two hydrophilic polymers. The hydrophilic polymers are selected from the group of polyvinylpyrrolidones having a K-Value of at least 80, polyvinylpyrrolidones having a K-Value of less than 80, copolymers of vinyl caprolactam, vinylacetate and ethylene glycol, copolymers of vinylpyrrolidone and vinylacetate, copolymers of ethylene and vinylacetate, polyethylene glycols, polypropylene glycols, acrylic polymers, and modified celluloses. The polymer mixture in the inner phase is present in an amount sufficient so that it forms a solid solution with the rotigotine base.
US11633365B2 Nucleic acid-containing lipid nanoparticle
The present invention provides a nucleic acid-containing lipid nanoparticle comprising an analog of a fatty acid ester of glycerol, and a nucleic acid, wherein the analog is not hydrolyzable by a lipase.
US11633363B2 Fusion proteins having a toxin and cancer marker, nanoparticles, and uses related thereto
This disclosure relates to nanoparticles coated with fusion proteins comprising a domain that binds a cancer marker and a domain comprising a toxic polypeptide. In certain embodiments, the targeted cancer marker is urokinase plasminogen activator receptor (uPAR) insulin-like growth factor 1 receptor (IGF1R), EGFR, HER2, and/or other member of the ErbB family of receptors. In certain embodiments, the molecule that binds a cancer marker is an amino terminal fragment of uPA or variant capable of binding uPAR and/or IGF1 or variant capable of binding IGF1R. In certain embodiments, the toxic polypeptide is a bacterial exotoxin.
US11633360B2 Method for preparing biodegradable microspheres using stabilized single-phase mixed solution
The present invention relates to a method for preparing biodegradable microspheres using a single-phase mixed solution containing water, alcohol, and dichloromethane. Provided is a method for preparing a biodegradable microsphere having a uniform drug loading efficiency by preparing and using a single-phase mixed solution in which no phase separation occurs without using a thickener and a surfactant. The preparation method of the present invention has the feature of keeping the content of a loaded drug uniform until a final biodegradable microsphere is prepared, by using a single-phase mixed solution in which no phase separation by a solvent occurs in the preparation process. Thus, the preparation method of the present invention is remarkably useful for the preparation of biodegradable microspheres.
US11633356B2 Nanostructured formulations for the delivery of silibinin and other active ingredients for treating ocular diseases
Formulations are described, containing silibinin or other active ingredients incorporated in lipid nanoparticle systems of the SLN and NLC type, and based on calixarenes, possibly mucoadhesive, or in micellar and nanoparticle systems based on amphiphilic inulin copolymers for use in the treatment of neurodegenerative ocular diseases. The versatility of the calixarene compound is also described, capable of charging and releasing active ingredients characterized by low water solubility, easy chemical and enzymatic degradation, low bioavailability, either of natural origin or not, to be used in the treatment of ocular diseases.
US11633354B2 Creatine and/or creatinine compositions and related methods
The disclosure is directed to methods related to creatinine, for example, a method for its safe administration to a human, a method for using creatinine to improve the bioavailability of creatine, and a metn.
US11633352B2 Diclofenac and hyaluronic acid combination treatment for oral leukpoplakia
An oral gel composition suitable for the treatment of oral leukoplakia comprising a combination of diclofenac with hyaluronic acid and methods of administering the oral gel that may include a device that prolongs contact time of the oral gel with the areas of the mucosa that are affected by oral leukoplakia.
US11633349B2 Topical therapy for the treatment of skin malignancies using nanoparticles of taxanes
Disclosed are methods useful for the topical therapeutic treatment of skin malignancies including skin cancers and cutaneous metastases using compositions containing nanoparticles of paclitaxel or other taxanes.
US11633347B2 Hydrous hair care compositions and methods
Methods and compositions for preventing or reducing hair frizz. The compositions are preferably oil-in-water or water-in-oil emulsions comprise at least one polysiloxane fluid component selected from an amodimethicone and a polysiloxane component comprising a plurality of hindered amine side chains. The compositions also comprise a silicone-compatible, volatile or non-volatile liquid carrier component, preferably comprising a component selected from a low molecular weight, volatile siloxy component; a hydrocarbon; and an alcohol. The compositions are preferably combing cremes, sprays or mousses, and are suitable for use a “leave-in” hair care product, or as a touch-up hair care product suitable for use during the day.
US11633345B2 Compositions systems and methods for conferring durable shaping of keratinous fibers
Cosmetic compositions, systems and methods for conferring responsive durable shaping of keratinous fibers employ at least one shape memory polymer that includes a three-armed branched polyethylene glycol (PEG) based polymer that is functionalized with one or more metal-coordination active groups. The shape memory polymer forms a crosslinked network coating on a substrate, for example a substrate selected from keratinous substrates, for example, hair. Hair coated with the shape memory polymer and treated with an oxidizing agent can be shaped, locked into shape, and reprogrammed by modulation of pH. The coated hair retains durable shaping properties through at least one shampoo treatment. The cosmetic compositions, systems and methods provide durable and reprogrammable durable shaping of the keratinous substrate, for example for styling hair.
US11633344B2 Oxidative hair cream composition containing thiophene azo colorant
This invention relates to an oxidative hair cream composition that contains at least one oxidative hair cream ingredient and at least one thiophene azo colorant.
US11633343B2 Liquid cosmetic
Compositions and methods of this disclosure include liquid cosmetic compositions, for example, an eyeliner, that is applied to the surface of a user (e.g., a person), the surface including, for example, an eyelid, the liquid cosmetic product including a ferromagnetic component that is capable of being attracted by and attached to a magnet, the magnet part of a false eyelash.
US11633341B2 Dental varnishes that release specifically targeted antimicrobial peptides and/or fluoride
In various embodiments a dental varnish system having improved peptide release and fluoride release properties is provided. In various embodiments a dental varnish system that provides release of an antimicrobial peptide, or specifically targeted antimicrobial peptide (STAMP), e.g., the peptide C16G2, is provided, with or without a fluoride. In various embodiments, a dental varnish system that provides release of a fluoride, with or without an antimicrobial peptide or STAMP is provided. In certain embodiments the dental varnish system comprises a first component that is a dry powder, said first component comprising a an antimicrobial peptide, with or without a fluoride, and a bulking agent, and a second component that is a fluid, said second component comprising a varnish solution, where combination of said first component with said second component provides a varnish formulation for application to the surface of a tooth.
US11633339B2 Cleansing compositions free of sodium chloride and sulfate-based surfactants
The present disclosure relates to cleansing compositions that are free of sulfate-based surfactants and free of sodium chloride. The cleansing compositions include: (a) one or more non-sulfate anionic surfactants; one or more amphoteric surfactants; one or more nonionic surfactants; (d) one or more hydrophobically modified poly(meth)acrylates; one or more silicones; and water. The cleansing compositions are particularly useful for cleansing hair and providing conditioning benefits to the hair.
US11633337B2 Oral care compositions and methods for the same
An oral care composition and methods for the same are disclosed herein. The oral care composition may include an orally acceptable vehicle, an anionic surfactant, and a nonionic surfactant. The anionic surfactant may include a C6-C18 fatty acid glutamate or a salt thereof, and the nonionic surfactant may include a C6-C18 alkyl polyglucoside. A weight ratio of the nonionic surfactant to the anionic surfactant may be from about 0.25:1 to about 9:1, or from about 1.8:1 to about 2.2:1.
US11633334B2 Alcohol containing non-antimicrobial cleansing composition
A non-antimicrobial cleansing composition is disclosed comprising from about 10.0 wt. % to less than about 40 wt. % of one or more C1-C8 alcohols; about 0.5 wt. % to about 10.0 wt. % of at least one primary surfactant; 0 wt. % to about 10.0 wt. % of at least one secondary surfactant, with the primary and secondary surfactants having an HLB value greater than 8; a pH adjusting agent; and water. The composition does not achieve a microbial kill level greater than 2.0 log.
US11633329B2 Feeding system for treating liquid medical waste
The present disclosure discloses a feeding system for treating liquid medical waste. The feeding system comprises a receiving container for storing liquid medical waste and a feeding container for accommodating a coagulant. The feeding container comprises an outlet and a seal for closing the outlet, and the receiving container comprises a feeding connector with a feeding channel. The feeding container and the receiving container are provided with a guide mechanism comprising guide lugs and guide slots, and the feeding connector is provided with a plurality of splitting portions arranged along the circumferential direction of the feeding channel and spaced apart from each other by a certain distance. The guide mechanism allows the operation of rotating the feeding container by a predetermined angle relative to the receiving container, and this operation causes the splitting portions to cut the seal along the circumference of the feeding channel to destruct the seal, thereby causing the coagulant accommodated in the feeding container flows into the receiving container through the outlet. The present disclosure provides a safe and convenient operation manner for adding a coagulant into a storage container of liquid medical waste.
US11633327B1 Flower-shaped massager
A flower-shaped massager includes an outer sleeve, and a lower shell and an upper shell inside. The lower shell is provided with a key switch and a circuit board. A driving mechanism electrically connected with the battery, the key switch and the circuit board is provided in the lower shell. The driving mechanism includes a motor and a swing member. An output shaft of the motor is connected with an eccentric wheel. An eccentric shaft of the eccentric wheel is connected with a connecting rod. One end of the connecting rod is connected with the swing member. The swing member is connected with a swing head inserted into a swing core. The motor is capable of driving the swing member together with swing core to swing back-and-forth under by the eccentric wheel and the connecting rod so as to realize either a massage function or a viewing function.
US11633320B2 Method of controlling walking assistance device and electronic device performing the method
A method for controlling an ankle-type walking assistance device may include measuring an angle of a joint of the walking assistance apparatus, calculating an angular velocity and a linear velocity of a frame of the walking assistance device using an inertial measurement unit (IMU) attached to the frame, generating a dynamics model for the walking assistance device based on the angle of the joint, the angular velocity and the linear velocity of the frame, calculating a disturbance applied to the walking assistance device based on the dynamics model, and controlling the walking assistance device based on the calculated force, equivalent, or wrench.
US11633319B2 Unpowered wearable walking assistance knee equipment with gait self-adaptivity
The present disclosure discloses an unpowered wearable walking assistance knee equipment with gait self-adaptivity comprising a left foot power output assembly, a right foot power output assembly, a left leg knee joint assistance execution assembly, a right leg knee joint assistance execution assembly and a driving force transmission device. The equipment of the present disclosure is based on lever principle and crank block structure principle and adopts an operation mode of combining ipsilateral parallel driving input and different sides cross driving input. The self-weight of the human body is utilized as a driving force during the walking process to enable the left foot power output assembly to provide the left leg knee joint assistance execution assembly with a pulling force for its stretching and to provide the right leg knee joint assistance execution assembly with a pulling force for its bending, and to enable the right foot power output assembly to provide the right leg knee joint assistance execution assembly with a pulling force for its stretching and to provide the left leg knee joint assistance execution assembly with a pulling force for its bending, so that a torque for assisting the stretching and bending of the left leg knee joint and the right leg knee joint is generated according to a gait cycle regularity during the walking process, and the goal of walking assistance is achieved.
US11633317B2 Comfort therapy
The present invention is a therapeutic pad with breast receiving cavities. The therapeutic pad with breast receiving cavities contains a platform, a cavity, and an adjustment element. The cavity traverses into the platform. The adjustment element is positioned within the cavity. The therapeutic pad with breast receiving cavities may take the form of a therapy device to replace surgical table padding, chiropractic dorsal pads, or other various therapeutic treatment table paddings to accommodate humans with breasts or additional curvature in the breast area. The therapeutic pad with breast receiving cavities constitutes specialized padding with breast recess areas to provide maximum comfort by allowing patients to control the pressure in the breast area when receiving therapeutic care or medical procedures.
US11633314B2 Automatic cleaning method and cleaning bed for patient of gatism
An automatic cleaning method and a cleaning bed for a patient of gatism are provided. The cleaning bed includes a bed body, a bed plate is arranged on the bed body and is provided with a through groove therein, a bed bottom plate is arranged on a lower part of the bed body, a lifting mechanism is arranged on the bed bottom plate and is provided with a soft cushion thereon, a fabric bracket is arranged under the bed plate and is provided with a material roller thereon, a pressing roller bracket is arranged under the bed plate and at one side close to the fabric bracket and is provided with provided with a first pressing roller and a second pressing roller.
US11633313B2 Patient support apparatus with touchscreen
A patient support apparatus, such as a bed, cot, stretcher, operating table, recliner, or the like, includes a litter frame, a support deck supported on the litter frame and adapted to support a mattress thereon, a touchscreen and a controller configured for carrying out various functions and to display various screens on the touchscreen, including screens for controlling a mattress therapy function or for controlling a non-mattress function of the patient support apparatus. A notification regarding the status of a mattress therapy function can be displayed on various screens. Status indications can be provided as a banner across a portion of the touchscreen.
US11633312B2 Absorbent article having outwardly convex longitudinal central channels for improved protection
An absorbent article having a pair of longitudinal edges, front and rear transverse edges, a front end region, a rear end region, and a central region disposed between the front and rear end regions. The absorbent article has a liquid pervious topsheet, a liquid impervious backsheet, an absorbent core disposed between the topsheet and the backsheet, a pair of outwardly convex longitudinal central channels formed at least in the central region. The traversal distance of the pair of outwardly convex longitudinal central channels decreases towards both ends of the channels to define a central closed area. The absorbent article has a rear channel defining a rear closed area in the rear end region.
US11633304B2 Wound dressing comprising a monitor interface
A wound dressing and a monitor device is disclosed, the wound dressing comprising a top layer; a first adhesive layer with a proximal surface configured for attachment of the wound dressing to the skin surface of a user; an absorbent core layer; an electrode assembly comprising a plurality of electrodes arranged on a distal side of the absorbent core layer; and a monitor interface configured for connecting the wound dressing to a monitor device, the monitor interface comprising a plurality of terminals configured to form electrical connections with respective terminals of the monitor device, wherein the wound dressing comprises a flexible element, the flexible element being bendable and/or twistable between a first flexible element end and a second flexible element end, and wherein the monitor interface comprises a coupling part positioned at the first flexible element end.
US11633303B2 Smart earmuff and method for improved use of an earmuff
An acoustic earmuff device comprising a pair of earmuff cup assemblies such that each is configured to be arranged at a location proximate to an ear of an user, wherein each earmuff cup assembly comprises means (320) for adapting a pressure applied to the location proximate to the ear so that the pressure around the ear is evenly distributed and a even seal is achieved, wherein the means for adapting a pressure comprises an adaptive layer (324) that is configured to apply the pressure around the ear evenly regardless whether that location comprises any protruding element (2).
US11633302B2 Patient interface device for ophthalmic surgical laser system
Apparatus and method for interfacing an ophthalmic surgical laser system with a patient's eye using a single-piece patient interface (PI). The PI includes a hollow shell, with an applanation lens and a flexible skirt at its lower end. Through channels are formed around the applanation lens to connect the spaces above and below the lens. When the PI is coupled to the laser system and the eye, the upper rim of the shell forms a seal with the laser system and the flexible skirt forms a seal with the eye. A vacuum is applied to the interior of the shell via a vacuum port on the laser system, and the vacuum is communicated to the space enclosed by the applanation lens, the skirt and the eye through the channels around the lens. A magnetic mechanism is also provided to hold the PI shell to the laser system.
US11633290B2 Standalone interbody spacer
A fastener retention system for a standalone interbody spacer that includes flexible members to configure to rotate from an “unlocked to a “locked” state to cover the screw holes in the interbody space to prevent bone engagement fasteners from backing out.
US11633285B2 Modified glenoid components and methods of installing same
A glenoid component for securement to a glenoid surface of a scapula comprises a body portion having a first surface adapted to contact the glenoid surface of a scapula and a second surface configured to receive the head portion of a humerus. The glenoid component further includes an anchor peg for penetrating the glenoid surface of the scapula so as to secure the body portion to the glenoid surface of the scapula. The anchor peg includes a cylindrical shaft extending from the first surface of the body portion and a fin secured to and extending outwardly from the cylindrical shaft. The glenoid component further includes a feature that prevents rotation of the glenoid component.
US11633284B2 Fold-up containment device for bone defects
A bone graft system includes a two-dimensional mesh sheet sized and shaped to, when folded along fold lines, form a three-dimensional graft containment structure configured to be packed with a bone graft material for placement within a target area of a bone, the mesh sheet including a first end flap connected to a remaining portion of the mesh sheet via a first fold line and a second end flap connected to the remaining portion of the mesh sheet via a second fold line, a third fold line extending from the first fold line to the second fold line so that the remaining portion is configured to be wrapped around folded first and second end flaps to form the graft containment structure, the first and second end flaps substantially corresponding to a profile of the target area of the bone.
US11633283B2 Components for artificial joints
A component of an artificial joint according to an exemplary aspect of the present disclosure includes, inter alia, a hollow tube including bone ingrowth material. Further, the hollow tube is selectively expandable. The bone ingrowth material allows the component to become biologically fixed to adjacent bone. Further, expansion of the hollow tube increases friction between the hollow tube and the adjacent bone, which increases stability.
US11633282B2 Kit of parts providing components implantable in a patient to adapt a neopenis of the patient for penetrative intercourse
A kit of parts includes components implantable in a patient to adapt a neopenis of the patient for penetrative intercourse. The kit of parts includes an implantable support, an implantable penile prosthesis, and an artificial glans penis. When implanted, the implantable support orients the implantable penile prosthesis and the artificial glans penis in an anatomically natal penis position that is adapted for penetrative intercourse.
US11633279B2 Prosthesis, delivery device and methods of use
Methods for delivering a replacement heart valve include advancing a delivery system through a femoral vein and into the atrium of a heart, wherein the delivery system includes an outer sheath assembly, a mid shaft assembly and an inner assembly. The outer sheath assembly and the mid shaft assembly are adapted to retain the replacement heart valve in a radially compacted state over the inner assembly. The outer sheath assembly is retracted to allow a plurality of distal anchors to self-expand while a portion of the replacement heart valve remains retained in a compacted state by the mid shaft assembly. The distal anchors are positioned to engage one or more native leaflets and the retained portion of the replacement heart valve is then released and allowed to fully expand for implanting the replacement heart valve within the native valve.
US11633276B2 IOL folding device
An intraocular lens (IOL) folding device is described.
US11633273B2 Prosthetic implant delivery device and method
A prosthetic implant transfer device is provided that may be used to insert a prosthetic implant through a surgical opening. In some embodiments, the device may comprise a flexible sheet of material that may be formed into an elongated hollow structure. The flexible sheet of material includes a plurality of fasteners that may be selected and engaged to define a desired size distal opening.
US11633268B2 Tooth shading, transparency and glazing
Systems, methods, and/or computer-readable media described herein provide technical solutions to the highly technical problems of machine generation of dental restorations. In particular, these systems, methods and/or computer readable media may provide technical solutions to aid in the creation of dental restorations that more closely resemble a natural tooth (including its internal optical structure). These systems, methods and/or computer readable media may help in virtually rendering a tooth, including its internal optical structure, and apply these renderings (e.g., digital models) to the fabrication of the dental restoration.
US11633267B2 Dental blank with an insert
A dental blank for the manufacture of a dental restoration. The dental blank comprises a dental block and an insert with an opening facing toward an outer surface of the dental blank. The insert comprises at least one positioning element for the positioning of an abutment.
US11633266B2 Holding attachment for denture abutment
A holding attachment includes a holding portion with a round or substantially round columnar hole shape in which a held portion of a material before cutting is inserted and a mounting portion that is mounted on a work mount of a cutting machine. The mounting portion includes at least one pin that is inserted to at least one pin insertion hole provided in the work mount and at least one engagement portion that is engaged with at least one rotation stopper provided in the work mount. A position reference portion of the material before cutting is recessed from a round or substantially round columnar outer peripheral surface of the held portion. The holding portion includes a fitting portion fit to the position reference portion of the material before cutting.
US11633264B2 Determining and tracking movement
Apparatuses, components, devices, methods, and systems for determining and tracking movement are provided. An example apparatus that includes a position indicating system having a first light emitter positioned and oriented to emit light in a first direction, a second light emitter positioned and oriented to emit light in a second direction, the second direction being collinear with and opposite to the first direction; and a third light emitter positioned and oriented to emit light in a third direction, the third direction being different than the first direction and the second direction. The third direction may be offset from the first direction by an offset angle that is an acute angle. The apparatus may also include a screen; an imaging system configured to capture an image of the screen. The first light emitter and the third light emitter may both be configured to emit light toward the screen.
US11633261B2 Dental appliance with repositioning jaw elements
The present disclosure provides method, computing device readable medium, and devices for dental appliances with repositioning jaw elements. An example of a method can include identifying a misaligned jaw of a patient from a virtual image of the patient's jaw, providing a treatment plan for the patient including a virtual model of a dental appliance having a first shell and a second shell configured to reposition at least one tooth of the patient, and adjusting the position of the repositioning jaw elements on the first shell and the second shell to comply with a number of constraints. The virtual model of the dental appliance including repositioning jaw elements on the first shell and the second shell configured to move a position of the misaligned jaw of the patient.
US11633259B2 Handpiece adapter for an endodontic file
In some embodiments, the current invention relates to a method and/or system for using a standard dental handpiece for endodontic cleaning. For example, a dental adapter is disclosed having a fitting for a standard dental handpiece, a torque limiter and/or a mount for an endodontic file. For example, the adapter may be single use and/or multi use. In some embodiments, the mount includes the torque limiter. For example, an endodontic file may be connected to the mount with a friction fitting that allows rotation of the file with respect to the mount at high torque. Optionally the mount is positioned eccentrically with respect to the fitting.
US11633258B2 Powder chamber and station for a powder chamber
A powder chamber, in particular for powder polishing devices, including a casing and two functional sectors, whereby the two functional sectors are arranged to be opposite to each other, and whereby at least one functional sector is designed to provide an opening for a working medium such as air or a mixture of powder and air, and whereby the two functional sectors are designed to allow the powder chamber to be locked. The two functional sectors are preferably arranged along an axis and are rotationally symmetric.
US11633256B2 Systems, methods, and media for selectively presenting images captured by confocal laser endomicroscopy
In accordance with some embodiments of the disclosed subject matter, systems, methods, and media for selectively presenting images captured by confocal laser endomicroscopy (CLE) are provided. In some embodiments, a method comprises: receiving images captured by a CLE device during brain surgery; providing the images to a convolution neural network (CNN) trained using at least a plurality of images of brain tissue captured by a CLE device and labeled diagnostic or non-diagnostic; receiving an indication, from the CNN, likelihoods that the images are diagnostic images; determining, based on the likelihoods, which of the images are diagnostic images; and in response to determining that an image is a diagnostic image, causing the image to be presented during the brain surgery.
US11633253B2 Robotic surgical devices, systems, and related methods
The embodiments disclosed herein relate to various medical device components, including components that can be incorporated into robotic and/or in vivo medical devices. Certain embodiments include various modular medical devices for in vivo medical procedures.
US11633250B2 Pocket and drape system for providing sterile fields
A pocket and drape system which provides multiple (e.g., at least two) sterile fields and the methodology for employing said pocket and drape system is provided. The system includes a base drape material having an upper edge, lower edge, first side edge, and second side edge to define a perimeter, where the base drape material also includes a first (outer) surface and a second (inner) surface. A first zone of pockets is present on a portion of the first surface and a second zone of pockets present on a portion of the second surface. The manner in which the base drape material is folded at first and second longitudinal fold lines and first and second transverse fold lines during assembly (e.g., prior to sterilization) maintains the sterility of the first zone of pockets and the second zone of pockets until each zone is ready for use during a medical procedure.
US11633246B2 Actuated grips for controller
Implementations relate to actuated grips for a controller. In some implementations, a controller includes a central member, a grip member coupled to the central member and moveable in a grip degree of freedom, a shaft coupled to the grip member, and an actuator coupled to the shaft and operative to output an actuator force on the shaft. The actuator force causes a grip force to be applied via the shaft to the grip member in the grip degree of freedom.
US11633244B2 Hand controller apparatus including ergonomic features for a robotic surgery system
A hand controller apparatus for controlling a tool in a robotic surgery system has a body with a proximal end and a distally located interface end that can be coupled to an input apparatus for controlling a surgical tool. The hand controller apparatus includes a control lever attached to a pivot joint proximate a side surface of the body and extending along the body and away from the proximal end, the control lever being laterally moveable relative to the side surface of the body about the pivot joint. The control lever includes a tail region adjacent to the pivot joint and a paddle region connected to the tail region and extending toward the distally located interface end. The tail region includes an inner surface facing the body and an outer surface opposing the inner surface, and at least part of the outer surface of the tail region is outwardly curved.
US11633241B2 Flexible wrist for surgical tool
The present invention is directed to a tool having a wrist mechanism that provides pitch and yaw rotation in such a way that the tool has no singularity in roll, pitch, and yaw. In one embodiment, a minimally invasive surgical instrument includes an elongate shaft having a working end, a proximal end, and a shaft axis between the working end and the proximal end; and an end effector. A wrist member has a flexible tube including an axis extending through an interior surrounded by a wall. The wall of the flexible tube includes a plurality of lumens oriented generally parallel to the axis of the flexible tube. The wrist member has a proximal portion connected to the working end of the elongate shaft and a distal portion connected to the end effector. A plurality of actuation cables have distal portions connected to the end effector and extend from the distal portion through the lumens of the wall of the wrist member toward the elongate shaft to proximal portions which are actuatable to bend the wrist member in pitch rotation and yaw rotation.
US11633240B2 Medical system, control device of medical support arm, and control method of medical support arm
A harmonized operation of a plurality of medical support arms is controlled more accurately. There is provided a medical system including an operation control unit configured to control, on the basis of information regarding a movable range (300a) of a first medical support arm (10a) being a control target, information regarding the movable range (300b) of a second medical support arm (10b) to be used together with the first medical support arm (10a), and a space position of a working point (Pa) in the first medical support arm (10a), an operation of the working point (Pa).
US11633239B2 Locking system for medical device drive system
A medical device drive system may include a locking structure, a locking device sized and shaped to engage with the locking structure, the locking device coupled to a drive system component, and a lifter configured to actuate the locking device into and out of engagement with the locking structure, wherein the drive system component is selectively lockable by movement of the lifter.
US11633238B2 Systems and methods for selecting, activating, or selecting and activating transducers
Transducer-based systems can be configured to display a graphical representation of a transducer-based device, the graphical representation including graphical elements corresponding to transducers of the transducer-based device, and also including between graphical elements respectively associated with a set of the transducers and respectively associated with a region of space between the transducers of the transducer-based device. Selection of graphical elements and/or between graphical elements can cause activation of the set of transducers associated with the selected elements. Selection of a plurality of graphical elements and/or between graphical elements can cause visual display of a corresponding activation path in the graphical representation. Visual characteristics of graphical elements and between graphical elements can change based on an activation-status of the corresponding transducers. Activation requests for a set of transducers can be denied if it is determined that a transducer in the set of transducers is unacceptable for activation.
US11633236B2 System and apparatus for guiding an instrument
A system and an apparatus for guiding an instrument may be provided, the apparatus comprising a main body; a holding member for holding an instrument, the holding member coupled to the main body; and one or more actuating members configured to effect movement of the holding member such that said movement of the holding member is capable of providing rotational movement of an instrument about a pivot point external the apparatus. The holding member may preferably be configured to co-operate with a compliance device, said compliance device capable of holding the instrument.
US11633235B2 Hybrid hardware and computer vision-based tracking system and method
The present disclosure relates to a tracking system for augmented reality in a clinical setting. Specifically, the present disclosure relates to an approach for combining hardware-based tracking and computer vision-based tracking in order to accurately overlay a projected image onto a video image.
US11633232B2 Device for interstitial laser therapy
Disclosed is a device for interstitial laser therapy. The device comprises an optical waveguide extending about a central longitudinal axis and having an optical output end; an optical diffuser optically coupled to, optically associate with, or positioned about the optical output end, wherein the optical diffuser comprises a housing having an open end for receiving the optical output end and a first longitudinal portion of the optical waveguide; and a temperature sensor interposed, positioned or located between the central longitudinal axis and an exterior surface of the housing, and preferably within the longitudinal extent of the first longitudinal portion of the optical waveguide. The optical diffuser can be provided with one or more holes, one or more slits, one or more openings, and/or one or more vents. The device can also include a second temperature sensor. Also disclosed is a system for interstitial laser therapy.
US11633229B2 3D electrical activity representation
In one embodiment, a medical system includes a catheter including electrodes, and configured to be inserted into a chamber of a heart and maneuvered among sampling sites to sample electrical activity, a display, and processing circuitry to receive signals provided by the catheter, and compute, for each sampling site, a sampling position of the catheter and respective electrode positions of the catheter electrodes, render to the display a 3D representation of the chamber including respective sampling-site markers indicating the computed sampling position of the catheter at respective ones of the sampling sites, receive a user input selecting one sampling-site marker, and update the 3D representation to include electrode markers indicating the respective electrode positions of the respective catheter electrodes while the catheter was sampling the electrical activity of the tissue at the sampling site corresponding to the selected sampling-site marker.
US11633224B2 Cryogen pump
Apparatus, consisting of a probe, containing a lumen and having a distal end configured to contact tissue of a living subject. A temperature sensor is located at the distal end, and a pump, having a pump motor, is coupled to deliver a cryogenic fluid through the lumen to the distal end of the probe and to receive the cryogenic fluid returning from the probe. There is a separator, coupled to separate the returning cryogenic fluid into a returning cryogenic liquid and a returning cryogenic gas, and a flow meter, coupled to measure a rate of flow of the returning cryogenic gas. A processor is configured to control a rate of pumping of the pump motor in response to a temperature measured by the temperature sensor and the rate of flow of the returning cryogenic gas.
US11633222B2 Bone cement mixing assembly
The invention provides a bone cement mixing assembly including a mixer, a syringe barrel and a movable plug cover. The mixer includes a stirring rod and a stirring barrel. The stirring rod has holding end, a rod body and a stirring end. The stirring barrel has a barrel cover, a first barrel open, a first barrel body, a first barrel bottom, and a stirring space located in the first barrel body. The syringe barrel has a second barrel open, a second barrel body, a second barrel bottom, and an injection space located in the second barrel body. In this way, the complete-stirred bone cement in the stirring barrel can be directly collected and pushed into the syringe barrel through the movement of the movable plug cover to achieve the effect of completing the preparation of the bone cement quickly and efficiently.
US11633212B2 Method and system for installing a sensor in a body
A system for installing a sensor, comprising: a puncture device comprising: a casing defining a cavity; an elongated member a sharp end; and a sensor assembly for measuring data about the body, the sensor assembly comprising: a sensing unit comprising a sensor for measuring the data and being engageable with the elongated member; a data unit for collecting the data, the data collecting unit being receivable within the cavity of the casing; and a communication cable extending between the sensing unit and the data collecting unit for transmitting the data to the data unit; wherein the sensor assembly is removably securable to the puncture device by inserting the data unit in the cavity of the casing and engaging together the sensing unit and the elongated member, the communication cable being tensed when the sensor assembly is secured to the puncture device.
US11633210B2 Sealing devices and surgical implements comprising same
Disclosed herein are sealing devices configured for improving sealing functionality with an engaged extension member of an apparatus. More specifically, disclosed herein are trocar sealing devices configured for improving insufflation gas containment in relation to trocars (and/or other related type of devices) that are used for enabling a surgical instrument such, for example, a laparoscope, to gain access to an abdominal cavity (or other body cavity). By providing for such improved insufflation gas containment, sealing devices as disclosed herein are particularly advantageous, desirable and useful in view of long-standing reasons for limiting insufflation gas leakage and in view of newly recognized reasons stemming from outbreak of COVID-19 disease for limiting insufflation gas leakage.
US11633209B2 Method for forming access route to bile duct and treatment method
In a method of forming an access route to the bile duct, a needle is introduced into a duodenum, and the introduced needle is pierced into an oral side projection of a duodenal papilla, which is located at an oral position than an opening of the duodenal papilla. The tip of the pierced needle is made to reach the inside of the bile duct to form a tunnel communicating the duodenum and the bile duct, and a treatment device is inserted into the formed tunnel.
US11633207B2 Methods and systems for performing submucosal medical procedures
Instruments, systems and methods are provided for performing submucosal medical procedures in a desired area of the digestive tract using endoscopy. Instruments include a safe access needle injection instrument, a submucosal tunneling instrument, a submucosal dissection instrument, a mucosal resection device. Systems include a combination of one or more of such instruments with or without injectable agents. Embodiments of various methods for performing the procedures are also provided.
US11633205B1 Lateral disc cutter with replaceable blades
A lateral disc cutter for morcellating and decorticating tissue of an intervertebral disc from between adjacent vertebrae. The device can be arranged in a retracted configuration for insertion via an access tube, and in an extended configuration for cutting of tissue in the target region. The blades may be extended to contact the concave endplate in an orientation that is substantially parallel to a mid-plane of the intervertebral disc. Blades of the device may be configured with a convex profile that substantially conforms to the concave shape of the endplate for enhanced contact length between the blade and the endplate. In some embodiments, the blades are configured for removal and replacement without need for tools, with the blades selectively determining a maximum displacement width of the morecellator assembly.