最新美国发明专利
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US10894160B2 Catheter and electrode systems for electrical neuromodulation
Embodiments of the present disclosure provide for catheters for use in electrical neuromodulation. The catheter of the present disclosure includes an elongate body having a first end and a second end. The elongate body includes a longitudinal center axis that extends between the first end and the second end. The elongate body further includes three or more surfaces that define a convex polygonal cross-sectional shape taken perpendicularly to the longitudinal center axis. The catheter further includes one or more electrodes on one surface of the three or more surfaces of the elongate body, where conductive elements extend through the elongate body. The conductive elements can conduct electrical current to combinations of the one or more electrodes.
US10894158B2 Electrode to nerve distance estimation
Estimating a nerve-to-electrode distance involves applying a stimulus from a stimulus electrode to a nerve. Neural measurements of at least one evoked compound action potential are obtained, and processed in order to estimate an originating state of stimulation exhibiting at least one characteristic defined by a single fibre size. A single fibre model is then applied to produce a measure of the nerve-to-electrode distance. Also provided for is estimation of a distribution of recruited fibres. Measurements of a compound action potential are obtained from sense electrodes spaced apart along a neural pathway. A conduction velocity of the compound action potential is determined from the latency between the measurements. From the conduction velocity a dominant recruited fibre diameter is determined. A rate of dispersion of the compound action potential between the sense electrodes is determined. From the rate of dispersion a distribution of diameters of the recruited fibre population is determined.
US10894152B2 Solution delivery device and method
The present specification discloses a solution delivery device having a container component and a plug component configured for selective engagement with the container component. The container component has an internal cavity including an elongated mixing channel containing a first constituent, and the plug component provides an internal flow path configured for introduction of a second constituent into the mixing channel for mixing with the first constituent. The plug component may be inserted within the container component partially in a first operational mode and fully in a second operational mode. The first constituent may be a drug and the second constituent a diluent, such that the drug may be lyophilized with the device in the first operational mode and reconstituted with the device in the second operational mode. Multiple devices may be employed in tandem for the co-delivery of multiple constituents. The device may be included in a kit or installed within an injector.
US10894151B2 Biosensor tattoos and uses therefor for biomarker monitoring
Provided herein are devices and methods used to produce tattoo biosensors that are based on spatially controlled intracutaneous gene delivery of optical reporters driven by specific transcription factor pathways for a given cytokine or other analyte. The biosensors can be specific to a given analyte, or more generically represent the convergence of several cytokines into commonly shared intracellular transcription factor pathways. These biosensors can be delivered as an array in order to monitor multiple cytokines. Biosensor redeployment can enable chronic monitoring from months to years. The tattooed biosensor array of the present invention includes endogenous reporter cells, naturally tuned to each patient's own biology and can be used to reliably measure the state of a patient in real-time.
US10894149B2 Dilation catheter assembly with adjustment features
A dilation catheter system includes a body, a guidewire, and a dilation catheter having an elongate shaft. The dilation catheter system may include a locking mechanism to prevent the guidewire from moving relative to the elongate shaft or to lock the guidewire to the dilation catheter to form a fixed wire unit. The dilation catheter system may include a stabilizing tube extending from an actuator, to provide rigidity to the guidewire. The dilation catheter may include a grip element having a plurality of grip features disposed thereon. The dilation catheter may include a cap biased toward a first longitudinal position and movable to a second longitudinal position. A guide catheter secured to the cap is prevented from changing angular orientation in the first longitudinal position and is free to change angular orientation in the second longitudinal position.
US10894146B2 Introduction of a catheter in a vein
The invention relates to a method for introducing a catheter in a vein, comprising the following steps: puncturing the vein, introducing a guide in the punctured vein, fixing a catheter on the distal coupler of a connector, introducing a mandrel in the catheter, introducing the set formed by the catheter and the mandrel in the vein by having said set slide on the guide, withdrawing the mandrel and the guide, and connecting a fluid injection device on the second proximal coupler of the connector.
US10894144B2 Apparatus and method for sensor deployment and fixation
A delivery system for an intracorporeal device includes a sheath defining one or more lumens shaped to receive a delivery catheter or shaft and a guidewire. The system may include a delivery shaft having a distal coupling feature adapted to releasably couple with a proximal coupling feature of the intracorporeal device. The delivery system may further include a hub through which the delivery shaft and guidewire are passed. The delivery shaft may be coupled to a feature, such as a knob, that enables manipulation of the delivery shaft to decouple the distal fixation feature from the proximal fixation feature of the intracorporeal device in order to deploy the intracorporeal device within a patient.
US10894141B2 Hyperthermic humidification system
Apparatus and methods for delivering humidified breathing gas to a patient are provided. The apparatus includes a humidification system configured to deliver humidified breathing gas to a patient. The humidification system includes a vapor transfer unit and a base unit. The vapor transfer unit includes a liquid passage, a breathing gas passage, and a vapor transfer device positioned to transfer vapor to the breathing gas passage from the liquid passage. The base unit includes a base unit that releasably engages the vapor transfer unit to enable reuse of the base unit and selective disposal of the vapor transfer unit. The liquid passage is not coupled to the base unit for liquid flow therebetween when the vapor transfer unit is received by the base unit.
US10894140B2 Device and method for diffusing high concentration NO with inhalation therapy gas
Systems and methods of the present invention can enable high concentration NO to be delivered into ventilator breathing circuits, via a diffusing device, without generating undesirably large amounts of NO2.
US10894139B2 Oxygen treatment device for mammals
Method and apparatus varies the oxygen concentration level of air delivered to a person for treatment on training purposes. The apparatus includes a display device for displaying current physiological data as well as data from previous sessions for comparison purpose. The oxygen level is precisely controlled by a central processing unit in response to input data from the person.
US10894133B2 Device for dispensing a fluid product
A dispenser device for dispensing a fluid or powder composition, the dispenser device comprising: a dispenser head (1) that is provided with a dispenser outlet (10) that is formed at the end of a hollow sleeve (3); an air expeller (20) for generating a flow of air while the device is being actuated, said air expeller including a piston (21) that slides in an air chamber (22) between a rest position and a dispensing position, said air chamber (22) including a cylindrical body in which said piston (21) slides in airtight manner; and a reservoir (30) that contains a single dose of composition, said reservoir (30) including an air inlet (31) that is connected to said air expeller (20), and a composition outlet (32) that is connected to said dispenser outlet (10), said air inlet (31) including a composition retainer member (40) for retaining the composition in the reservoir (30) until the composition is dispensed, and said composition outlet (32) being closed by a closure element (50) that is force fitted in the composition outlet (32) of the reservoir (30); said device further comprising a mechanical opening system (61, 62) that co-operates with said closure element (50) so as to expel it mechanically from its closed position while the device is being actuated; said device further comprising an indicator (100; 50) that, in the rest position before actuation, is in a first state, and that after actuation passes into a second state, the passage from the first to the second state informing the user that the device has been actuated, said first state being a visible state and said second state being a non-visible state, said device including a pusher element (25) that is secured to said piston (21), and on which the user presses during actuation, said dispenser head (1) including a skirt (5) that is arranged around said air chamber (22), said pusher element (25), in its rest position before actuation, projecting axially out from said skirt (5), and after actuation, being arranged inside said skirt (5), said pusher element (25) including an indicator (100) that is visible before actuation and that is not visible after actuation.
US10894132B2 Auto-injector
An auto-injector for administering a dose of a liquid medicament (M) is present having a tubular chassis telescopable in a tubular case, a carrier subassembly comprising a tubular carrier slidably arranged relative to the chassis inside the case, where the carrier is adapted to contain a syringe with a hollow injection needle. The injector also has a drive spring and a plunger for forwarding load of the drive spring to a stopper of the syringe, wherein the syringe is lockable for joint axial translation with the carrier. A control spring is arranged around the carrier for translating the carrier in a proximal direction (P) for insertion of the needle through the chassis into an injection site.
US10894126B2 Fluid infusion system that automatically determines and delivers a correction bolus
A method of controlling an insulin infusion device involves controlling the device to operate in an automatic basal insulin delivery mode, obtaining a blood glucose measurement for the user, and initiating a correction bolus procedure when: the measurement exceeds a correction bolus threshold value; and a maximum basal insulin infusion rate is reached during the automatic basal insulin delivery mode. The correction bolus procedure calculates an initial correction bolus amount, and scales the initial amount to obtain a final correction bolus amount, such that a predicted future blood glucose level resulting from simulated delivery of the final correction bolus amount exceeds a low blood glucose threshold level. The final amount is delivered to the user during operation in the automatic basal insulin delivery mode.
US10894124B2 Medical injector system
A syringe includes a body and a plunger movably disposed within the body. The syringe may be used with an injector including a drive member. The drive member preferably includes at least one pin adapted to form a retractable abutting connection with an interior of a plunger to enable the drive member to retract the plunger with the body of the syringe.
US10894122B2 Application member and medical instrument
A sheet-shaped application member includes: a first region, and a second region extending around the first region, wherein: the first region comprises a first region attachment surface to which a medical device is attachable, and a first region application surface opposite the first region attachment surface and adapted to be applied to a subject, the second region comprises a second region application surface adapted to be applied to the subject, and the first and second application regions are adapted such that, when the application member is applied to the subject, adhesion at the second region application surface is stronger than adhesion at the first region application surface; and an application member tear portion adapted to allow for tearing of a portion within the first region or for tearing the first region from the second region.
US10894119B2 System for proportioning fluids
The present invention concerns a system for preparing a ready-to-use peritoneal dialysis fluid. The system comprises a) a proportioning device; b) at least one source of water; c) at least one source of first concentrate adapted for connection with a) and b), d) at least one source of second concentrate adapted for connection with a) and b), and optionally, e) at least one source of further concentrate adapted for connection with a) and b), wherein the first concentrate comprises glucose and has a pH of between 1.5 and 4, and wherein the second concentrate comprises a physiologically acceptable buffer and has a pH of between 5.5 and 9.0.
US10894118B2 Apparatus and method for urea photo-oxidation
Apparatus and method for photo-chemical oxidation are disclosed herein. In one embodiment, a method for regenerating a dialysis fluid includes: flowing the dialysis fluid between an anode and a cathode of a dialysis system, where the anode comprises a plurality of nanostructures; illuminating the anode with a source of light; flowing oxygen through the cathode toward the dialysis fluid; and converting urea in the dialysis fluid into CO2, N2 and H2O thereby regenerating the dialysis fluid.
US10894117B2 Hollow molded article
Disclosed is a hollow molded article which has an opening portion communicating with a flow channel and which can be manufactured simply. The hollow molded article includes a panel and flow channels. The panel includes a first resin sheet and a second resin sheet partly welded with the first resin sheet. The flow channels are disposed between the first resin sheet and the second resin sheet, and include connection portions for external connection which are disposed on a peripheral edge of the panel. The connection portions are formed by the first resin sheet and the second resin sheet.
US10894113B1 Prosthetic implantable antibacterial surgical mesh
The disclosed invention is directed to an implantable surgical prosthetic mesh having a nanofiber comprising one or more antibiotic and a polysaccharide, and a non-polysaccharide polymer deposited on the mesh. The mesh of the invention is shown to be effective in eliminating or minimizing the bacterial population in the mesh and surrounding tissue for at least 14 days from surgical implantation of the mesh.
US10894111B2 High refractive index hydrophilic materials
A hydrophilic intraocular lens (IOL) with high refractive index comprising at least one copolymer comprising: ((a) a first monomeric subunit comprising (i) a polymerized (meth)acrylate group and an aliphatic carbon moiety comprising at least two hydroxyl substituents or (ii) a polymerized (meth)acrylamide group, (b) a second monomeric subunit different from the first monomeric subunit comprising a polymerized (meth)acrylate group, at least one side group comprising (i) an aryloxy moiety comprising at least one halogen, and (ii) an aliphatic carbon moiety linking the aryloxy moiety with the polymerized (meth)acrylate group, wherein the aliphatic carbon moiety comprises optionally at least one hydroxyl substituent, (c) a third monomeric subunit different from the first and second monomeric subunits comprising a polymerized (meth)acrylate group and at least one alkoxyalkoxyalkyl side group.
US10894107B2 Fogging system providing atomized solution and ultraviolet light to treatment area
A system for disinfecting an enclosed area may include at least one ultraviolet (UV) light and a fogging device which may include a portable housing, an atomizing disinfectant generator carried by the portable housing, and a processor carried by the portable housing. The processor may be configured to initiate a treatment cycle during which the atomizing disinfectant generator dispenses atomized disinfectant fluid into the enclosed area, after a first time period activate the at least one UV light while the atomized disinfectant fluid is being dispensed into the enclosed area, and after a second time period later than the first time period deactivate the at least one UV light and prior to completion of the treatment cycle.
US10894100B2 Cleaning and disinfecting cradle for head worn items
Some embodiments of the present disclosure include a disinfecting/cleaning box for disinfecting and cleaning a head worn item. The disinfecting/cleaning box may include a chamber having an inner volume sufficient to accommodate the head worn item; and an ultraviolet (UV) light source provided in the chamber, wherein the UV light source is disposed to shine UV light onto a surface of the head worn item.
US10894098B2 Methods and compositions for targeted imaging
A new approach to targeting imaging agents to macrophage-rich sites of interest is disclosed. Compositions of the invention are rHDL and HDL-like liposomal compositions, protein constituents of which, apolipoproteins A-I and/or A-II or fragments thereof are used not only as structural but also as targeting agents. This is achieved by certain controlled chemical or enzymatic modification of apolipoproteins A-I or A-II or fragments thereof. Such modification converts these apolipoproteins to substrates for macrophage scavenger receptors and results in the improvement of contrast agent-(HDL/modified apolipoprotein)-particle association with macrophages and/or absorption (uptake) by macrophages when compared to that of the contrast agent-(HDL/apolipoprotein)-particle constructed with non-modified naturally occurring apo A-I. The compositions can be used for noninvasive specific in vivo molecular detection and localization of macrophage-rich sites of interest using imaging techniques such as computed tomography (CT), gamma-scintigraphy, positron emission tomography (PET), single photon emission computed tomography (SPECT), magnetic resonance imaging (MRI).
US10894097B2 HER2 binders
Imaging agents comprising an isolated polypeptide conjugated with a radionuclide and a chelator; wherein the isolated polypeptide binds specifically to HER2, or a variant thereof; and methods for preparing and using these imaging agents.
US10894095B2 Multipurpose medical image indicator and method for manufacturing the same
The present disclosure concerns a medical image indicator. More particularly, it concerns the multipurpose medical image indicator including more than one of fluorophores and MRI contrast agent/CT contrast agent and method for manufacturing same. Responding to a demand for non-invasive and effective way of marking lesions, the present disclosure provides a method for manufacturing the multipurpose medical image indicator including a provision of rubber material fluid composition; a mixing of the rubber material fluid composition and fluorophores; and a transfiguring and drying of the mixture and the multipurpose medical image indicator manufactured according to the method. Further, the present disclosure provides a ligation device for endoscope including the multipurpose medical image indicator.
US10894093B2 Method of engineering drug-specific hypersensitive t-cells for immunotherapy by gene inactivation
The present invention relates to therapeutic cells for immunotherapy to treat patients with cancer. In particular, the inventors develop a method of engineering drug-specific hypersensitive T-cell, which can be depleted in vivo by the administration of said specific drug in case of occurrence of a serious adverse even. The invention opens the way to standard and affordable adoptive immunotherapy strategies for treating cancer.
US10894085B2 System for thermotherapy treatment or prevention of antimicrobial resistant or biofilm infections
The system comprises a support to receive a nanoparticle assembly (NPA) and to be conveyed towards a localized area of an organism infected or at risk to be infected by microorganisms; said nanoparticle assembly (NPA) comprising a plurality of nanoparticles (NPs) each one (NP) having a metal core and a surface surrounding said metal core, the metal core being reactable to thermal energy; and an energy unit (15) configured to apply at least one thermal shot on said localized area exposed to the nano-particle assembly, increasing the temperature of said localized area via the. nanoparticle assembly (NPA), so enabling a nanotheranostic multimodal antimicrobial therapy, wherein the metal core being made of silver, gold, iron or a mixture of silver and gold.
US10894072B2 Compositions and methods for treating fibromyalgia
Embodiments of the invention generally relate to supplements for treating fibromyalgia and symptoms associated with fibromyalgia, wherein the nutritional supplement is administered for at least one of following: fatigue, chronic pain, morning stiffness, headaches, and problems with thinking and memory.
US10894070B2 Drug compound for the control of blood glucose, blood lipids and weight
A pharmaceutical composition includes an alcohol-soluble, water insoluble, extract of Radix Glycyrrhizae; and wolfberry. A weight ration of the extract and wolfberry is 0.01˜5:15˜25. The composition is useful for controlling blood glucose and blood lipids, and for weight control. Health food products containing the recited combination are also provided.
US10894068B2 Bordetella bronchiseptica bacteriophage Bor-BRP-1, and use thereof for inhibition of proliferation of Bordetella bronchiseptica bacteria
The present invention relates to a Podoviridae bacteriophage Bor-BRP-1 (accession no. KCTC 12705BP) isolated from nature, which has an ability to specifically kill Bordetella bronchiseptica bacteria and has a genome represented by SEQ ID NO: 1; and a method for preventing and treating infection with Bordetella bronchiseptica bacteria using a composition comprising the same as an active ingredient.
US10894066B2 Amnion derived therapeutic compositions and methods of use
Therapeutic compositions are described for the treatment of a variety of conditions including heart, eye, lungs, organs, joints, dermal, nerve, and the like. A therapeutic composition may be a fluid comprising amniotic fluid or micronized amniotic particles. A therapeutic composite may be a dispersion of micronized amniotic membrane combined with a fluid, such as plasma, saline, amniotic fluid, combinations thereof and the like. In another embodiment, the therapeutic composite is a mixture of micronized amniotic membrane particles combined with an amniotic rich stem cell fluid. An amniotic rich or concentrated stem cell fluid comprises at least 0.5×106 amniotic stem cells per milliliter of fluid or composition. A therapeutic composite may be used to treat any number of conditions through topical application, surgical introduction, and/or injection.
US10894065B2 Methods for production of platelets from pluripotent stem cells and compositions thereof
Methods for production of platelets from pluripotent stem cells, such as human embryonic stem cells (hESCs) and induced pluripotent stem cells (iPSCs) are provided. These methods may be performed without forming embryoid bodies or clusters of pluripotent stem cells, and may be performed without the use of stromal inducer cells. Additionally, the yield and/or purity can be greater than has been reported for prior methods of producing platelets from pluripotent stem cells. Also provided are compositions and pharmaceutical preparations comprising platelets, preferably produced from pluripotent stem cells.
US10894062B2 Vitamin supplement compositions for injection
The embodiments relate to improved vitamin supplement compositions formulated for administration to patients, particularly improved vitamin compositions formulated for use in cosmetic or therapeutic applications. The compositions may be used to slow aging process and promote wellness including treating a vitamin deficiency, skin conditions, improving skin appearance, wound healing and scar prevention and hair loss.
US10894060B2 Compositions and therapies using nanodiamonds suspended in a carrier
A composition to treat epidermal insults comprises suspended nanodiamonds. The nanodiamonds may be unagglomerated and ungraphenated detonation synthesis nanodiamonds at 2 nm to 4 nm in initial crystal size and 0.2%-0.5% composition weight. The nanodiamonds may be suspended homogeneously in medical grade Sea Buckthorn berry oil. The nanodiamonds may be suspended in group consisting of Sea Buckthorn berry oil, Sea Buckthorn seed oil, glycerin, olive oil, Dimethyl sulfoxide (DMSO), hand creams such as those sold under the tradename UDDERLY SMOOTH and WORKING HANDS (e.g., Udderly Smooth, Working Hands), hydrocortisone cream, triple antibiotic ointment, and combinations thereof. The nanodiamonds can be agglomerated crystals 30 nm to 50 nm in diameter.
US10894059B2 NADH compound composition, and preparation and use thereof
An NADH compound, and a formulation and use thereof, relating to the technical field of biomedicine and health care products. The NADH compound includes NADH or its physiologically acceptable salt and L-carnitine or its physiologically acceptable salt, and can be used as a weight loss product. The NADH compound has an increased effect in weight loss, and may achieve long-term drug administration of the product.
US10894058B2 Method for producing solid dispersion containing hardly soluble polyphenol
Provided is a method of producing a solid dispersion that can improve solubility of a hardly soluble polyphenol in water. Specifically, provided is a method of producing a solid dispersion containing an amorphous hardly soluble polyphenol, the method including the steps of: mixing (A) a hardly soluble polyphenol, (B) at least one selected from the group consisting of a plant-derived polysaccharide, a seaweed-derived polysaccharide, and a microorganism-derived polysaccharide, a plant-derived polypeptide, and a microorganism-derived polypeptide, and (C) at least one selected from the group consisting of a monosaccharide and a disaccharide, followed by melting of the mixture by heating; and solidifying the molten product by cooling.
US10894050B2 Methods of synthesizing thyroid hormone analogs and polymorphs thereof
The disclosure describes methods of synthesis of pyridazinone compounds as thyroid hormone analogs and their prodrugs. Preferred methods according to the disclosure allow for large-scale preparation of pyridazinone compounds having high purity. In some embodiments, preferred methods according to the disclosure also allow for the preparation of pyridazinone compounds in better yield than previously used methods for preparing such compounds. Also disclosed are morphic forms of a pyridazinone compound. Further disclosed is a method for treating resistance to thyroid hormone in a subject having at least one TRβ mutation.
US10894049B2 Pharmaceutical formulation of palbociclib and a preparation method thereof
The present invention belongs to the pharmaceutical field, and in particular, it relates to a pharmaceutical formulation of palbociclib and a preparation method thereof. The pharmaceutical formulation comprises palbociclib, an acidic auxiliary material, and optionally a hydrophilic high-molecular material, which has better solubility and in vitro dissolution property as compared with the conventional formulation and can be used for enhancing in vivo absorption and bioavailability of palbociclib.
US10894047B2 Bupropion as a modulator of drug activity
Dosage forms, drug delivery systems, and methods related to sustained release of dextromethorphan or improved therapeutic effects are disclosed. Typically, bupropion or a related compound is orally administered to a human being to be treated with, or being treated with, dextromethorphan.
US10894045B2 Methods for solid tumor treatment
Disclosed herein are methods for treating solid tumors by direct injection into the tumors of chemotherapeutic particles, methods for inhibiting tumor metastasis by administering chemotherapeutic particles to a subject having a tumor, and compositions that include chemotherapeutic particles, small amounts of a polysorbate, and a carrier.
US10894044B2 Combination of topoisomerase-I inhibitors with immunotherapy in the treatment of cancer
The present disclosure relates to compositions and methods for treating cancer, more specifically to methods and compositions comprising a Topoisomerase I inhibitor and an α-PD-L1 antibody.
US10894043B2 Pharmaceutical composition
The present invention relates to a therapeutic agent for an ophthalmic disease comprising a vascular endothelial growth factor (VEGF) receptor inhibitor or an epidermal growth factor (EGF) receptor inhibitor in a nanoparticle form, having a property to be retained in a posterior eye tissue when systemically administered.
US10894042B2 Methods and pharmaceutical compositions for the treatment of cancer
The present invention relates to methods and pharmaceutical compositions for the treatment of cancer. More particularly, the present invention relates to a method of treating cancer in subject in need thereof comprising administering the subject with a therapeutically effective amount of at least one OX1R antagonist.
US10894041B2 Medical treatments based on anamorelin
Methods of treating cancer related conditions using anamorelin are described.
US10894040B2 S1P modulating agents
The present invention provides compounds of formula (I) or (II) or a pharmaceutically acceptable salt thereof and their use in modulating the activity of S1P) receptors. Also provided is a pharmaceutical composition comprising the compounds of formula (I) or (II) or a pharmaceutically acceptable salt thereof and a pharmaceutically acceptable excipient or carrier.
US10894038B2 Indolizine derivatives, composition and methods of use
Provided are certain URAT1 inhibitors, pharmaceutical compositions thereof, and methods of use therefor.
US10894035B2 Use of indole compounds to stimulate the immune system
Methods for treating immunodeficiencies are provided using indole-based compounds.
US10894034B2 Anti-neoplastic compounds and methods targeting QSOX1
Compounds and methods involving inhibition of the enzymatic activity of QSOX1 (FIG. 13). The compounds and methods can be used in treatment of neoplastic cells, for example, to suppress tumor growth and invasion in a variety of cancers, including but not limited to myeloma and cancers of the breast, kidney, and pancreas.
US10894031B2 Polyphenol-reactive oxygen species compositions and methods
Disclosed herein are nutraceutical compositions comprising or consisting essentially of one or more types of polyphenols (e.g., a green tea polyphenol) and one or more types of reactive oxygen species, and methods for their use to treat gastrointestinal conditions, inflammatory conditions, and immune conditions.
US10894028B2 Methods of reducing the risk of a cardiovascular event in a subject at risk for cardiovascular disease
In various embodiments, the present invention provides methods of reducing the risk of a cardiovascular event in a subject on statin therapy and, in particular, a method of reducing the risk of a cardiovascular event in a subject on statin therapy having a fasting baseline triglyceride level of about 135 mg/dL to about 500 mg/dL, and administering to the subject a pharmaceutical composition comprising about 1 g to about 4 g of eicosapentaenoic acid ethyl ester or a derivative thereof.
US10894026B2 Pharmaceutical compositions comprising a fumaric acid ester and method for the preparation thereof
The present invention relates to a delayed release pharmaceutical composition comprising a fumaric acid ester such as Dimethyl fumarate in the form of gastro-resistant tablets filled into hard gelation capsule.
US10894025B1 Amino acid compositions
Compositions comprising the nitrate of arginine are disclosed. In some aspects, the nitrate of arginine is a salt of a nitric acid (NO3−) or a mixed salt of a nitric acid (NO3−). The compositions further comprise one or more additional components selected from the group consisting of a carrier, an excipient, a binder, a colorant, a flavoring agent, a preservative, a buffer, and a dilutant. In one aspects, the composition is in a dosage form selected from the group consisting of a capsule, a cachet, a pill, a tablet, a powder, a granule, a pellet, a bead, a particle, a troche, and a lozenge. In other aspects, the composition is for human ingestion. In some embodiments, the composition, for example the composition for human ingestion, is a human dietary supplement.
US10894020B2 Hybrid nanoparticles containing boron-doped graphene quantum dots and applications thereof
Provided is a hybrid nanoparticle, including an aggregate assembled from a plurality of polymeric molecules, and a plurality of boron-doped graphene quantum dots localized in the aggregate. The polymeric molecule is preferably a pH-responsive dendrimer; the polymeric molecule and the boron-doped graphene quantum dot may be separately associated with different drugs; and hybrid nanoparticle may further include a targeting molecule, such as a rabies virus glycoprotein. Also provided is a method of controlling disassembly of a hybrid nanoparticle, including applying a high-frequency magnetic field to the hybrid nanoparticle to induce disassembly thereof. Also provided is an application of the hybrid nanoparticle for preparing a tumor-penetrating drug carrier.
US10894013B2 Composition and method for reducing allergic response
A method and kit for the sequential early introduction to an infant of at least two allergens to decrease the infant's risk for developing allergies, the method involving administering an initial lower, exposure dose of a first allergen for a day or two, followed by administering a higher maintenance dose of the first allergen for several days, followed by administering the maintenance dose of the first allergen and an initial lower, exposure dose of a second allergen for a day or two, followed by administering the higher maintenance dose of the first allergen and a higher maintenance does of the second allergen for several days. The allergens can be provided in powdered protein form in premeasured pouches for addition to baby formula or to mother's milk. Alternatively, the allergens can already be provided in baby formula, or in other foods such as snack bars, cookies, or gels.
US10894004B2 Composition
A dental product in the form of a solid includes a mineral source. The mineral source includes a source or sources of calcium ions, phosphate ions or both calcium ions and phosphate ions. The dental product also includes a salt of carbonic acid, an acidifying agent and xylitol. The acidifying agent includes at least citric acid and malic acid, wherein the citric acid and malic acid are present in a weight ratio of from 4:1 to 1:1.
US10894003B2 Medicine cassette, medicine dispensing apparatus and medicine packaging apparatus
A medicine cassette 100 includes a side-wall constituent body 110, a first rotating body 120, a second rotating body 130 and a medicine discharging part 144c. The medicine cassette 100 can scrape up medicines prepared in a medicine containing part 182 along with a rotation of the first rotating body 120 to transfer and place the medicines onto the second rotating body 130 and transfer the medicines toward a downstream side of a rotational direction of the second rotating body 130 to discharge the medicines from the medicine discharging part 144c. An expanding portion 110a expanding toward an outer side of a radial direction of the second rotating body 130 is provided in the side-wall constituent body 110 on a lower side of the second rotating body 130.
US10894001B2 Pill pulverizing kit
A pill pulverizing kit is a system that contains, processes, and subsequently dispenses pills and similar hard medications. The system includes a tubular receptacle, a crushed-pill repository, and a plurality of pill-processing devices. The tubular receptacle is a container utilized as the primary housing for pills both before and after pulverizing, as well as the housing for the components involved in crushing and consumption. The crushed-pill repository is a curved indent that collects and contains crushed pill material until the user is prepared to consume or serve the pill powder. The plurality of pill-processing devices relates to a series of removable additions to the tubular receptacle that provide various functions, including pill pulverization and content dispensing and consumption. The plurality of pill-processing devices includes a lid for consumption, as well as an impact driving mechanism that generates power and force for pulverizing pills.
US10893996B2 Surgical frame having translating lower beam and moveable linkage or surgical equipment attached thereto and method for use thereof
A surgical frame and method for use thereof is provided. The surgical frame is capable of reconfiguration before, during, or after surgery using a moveable main beam supporting a patient thereon. The surgical frame includes a translating lower beam that is moveable between at least a first lateral position and a second lateral position, and a linkage and/or surgical equipment supportively and moveably attached to the translating lower beam or interconnected with the translating lower beam via the linkage. The linkage and/or the surgical equipment are moveable between a first position at or adjacent a first end of the translating lower beam and a second position closer to a second end of the translating lower beam than the first position. The translating lower beam is used to join a first support portion and a second support portion of the surgical frame to one another, and movement of the translating lower beam affords access to a patient receiving area. A linear movement mechanism can be used to facilitate movement of the linkage and/or the surgical equipment along the translating lower beam to avoid interference with the main beam or the translating lower beam.
US10893990B1 Method and apparatus for treating an inside volume of a mobile vehicle
A treatment apparatus and method of treating an inside volume of a mobile vehicle using the apparatus. The method includes the steps of: a) placing a treatment unit in an operative position with respect to the mobile vehicle, the treatment unit having: i) a frame; ii) a source of UV light; and iii) an air mover for controllably directing air within the inside volume to be exposed to UV rays generated by the UV light source; and b) operating the treatment unit and thereby causing air within the inside volume to be disinfected by UV light rays from the UV light source and circulated within the inside volume.
US10893989B2 Autonomous critical care systems and integrated combat casualty care systems
Systems, devices, and methods for monitoring and treating a patient on route to a medical facility are disclosed. The system comprises a critical care unit; at least one patient monitoring device coupled to the critical care unit, wherein the critical care unit obtains physiological data about the patient from each patient monitoring device; at least one patient treatment device coupled to the critical care unit, wherein the critical care unit provides treatment instructions to each patient treatment device; a two way communications device coupled to the critical care unit; and a remote communications terminal in communication with the two way communications device. The critical care unit preferably sends the physiological data to the remote communications terminal and receives the treatment instructions from the remote communications terminal via the two way communications device.
US10893988B2 Patient support systems and methods for docking, transporting, sterilizing, and storing patient support decks
Patient support systems and methods for docking, transporting, sterilizing, and storing patient support decks. The patient support system comprises patient support decks that are configured to carry patients, such as in emergency situations or in a healthcare facility. The patient support decks are adapted to be engaged by docking stations and transport devices. Different configurations of docking stations and transport devices are contemplated. Sterilization apparatuses are provided to sterilize the patient support decks after use and storage facilities store the patient support decks for later use once they are sterilized.
US10893987B2 Disposable diapers with main channels and secondary channels
Disposable absorbent diapers are provided with improved comfort, fit and liquid transportation. The absorbent core of the disposable absorbent diapers includes at least one absorbent structure having a substrate layer and an absorbent layer with channels.
US10893986B2 Underpants-type disposable diaper with reduced lateral side seal tearing
An underpants-type disposable diaper includes outer members 12F and 12B having stretchable regions A2 and A3 disposed adjacent to the inner edges of the side seal portions 12A in the width direction. The stretchable regions A2 and A3 include multiple elongated elastically stretchable members 19 disposed between two sheet layers 12S and 12H at predetermined intervals in the front-back direction and extending in the width direction. The elastically stretchable members 19 each include two fixed ends 19f fixed to the two sheet layers 12S and 12H, and the section between the fixed ends 19f is unfixed to the two sheet layers 12S and 12H. The two sheet layers 12S and 12H are welded into sheet bonding sections 20, at positions between the elastically stretchable members 19 in the stretchable regions A2 and A3 adjacent is the front-back direction. No sheet bonding section protrudes from the side seal portion in the stretchable regions A2 and A3.
US10893985B2 Elastic structure for absorbent article and method for manufacturing elastic structure for absorbent article
An object of the present invention is to provide an elastic structure that has straightly extended ridges with excellent appearance, air permeability, and fluffy feel. The object can be attained by an elastic structure in which a first sheet material (12S) and a second sheet material (12H) are joined together to form sheet joined sections (70) by an adhesive (71) applied intermittently in an extending direction and continuously in a direction intersecting with the extending direction, resilient and elastic members (15 and 16) are fixed by the adhesive (71) to at least one of the first sheet material (12S) and the second sheet material (12H) at intersections with the sheet joined sections (70), and when the first sheet material (12S) and the second sheet material (12H) are contracted with contraction of the resilient and elastic members (15 and 16), portions of the first sheet material (12S) and the second sheet material (12H) positioned between the sheet joined sections (70) are swelled in mutually opposite directions to form ridges (80), and the sheet joined sections (70) have a width (70w) of 0.5 to 4 mm in the extending direction and spacing (70d) between the adjacent sheet joined sections (70) is 4 to 8 mm.
US10893983B2 Method for dressing a wound
A method for dressing a wound is provided including providing a wound dressing pad of hydrophobic fabric that is treated to bind microorganisms; placing the hydrophobic fabric so that it faces the wound; and applying negative pressure therapy to the wound dressing so that microorganisms in the wound surface adhere to the dressing through hydrophobic interaction. The negative pressure therapy may be alternated with hyperbaric oxygen treatments of the wound dressing.
US10893981B2 Wound dressing with a bacterial adsorbing composition and moisture holding system
The invention herein relates to a wound dressing product, combining a hydrophobic fabric, which is to be placed towards the wound, and is capable of binding unwanted microorganisms, and a moisture carrying matrix such as a gel or a foam. The product of the invention is ideal for treatment of drier wounds. It protects the wound and reduces the number of pathogenic microorganisms, without using antimicrobial substances and at the same time adds or traps moisture to the wound both supporting the hydrophobic functioning of the pad and healing in general by keeping the wound moist.
US10893979B2 Creation of curved cuts in the inside of the eye cornea
A device for isolating a lenticle in the cornea of an eye. The device includes: a laser beam source to emit pulsed laser radiation having a pulse frequency of 1.2 MHz to 10 MHz, a pulse energy of 1 nJ to 200 nJ and a wavelength penetrating the cornea; a beam-forming unit having beam optics with an image field and that bundles pulsed laser radiation into a focus located inside the image field, and which has a maximum diameter of less than 3 μm; a beam-deflection unit shifting the focus in the cornea and inside the image field, the focus moving along a path when the image field is resting; and a control unit to control the source and the beam-forming unit to isolate the lenticle by specifying the path. The lenticle is delimited by a cut surface which is curved with regard to a front surface of the cornea.
US10893970B2 Hip spica cast and undergarment for use with hip spica cast
An undergarment for use with a cast tape to form a hip spica cast, such as a pantaloon-type hip spica cast, The cast includes at least one layer of a 3D spacer synthetic padding material formed into a fabric of monofilament yams and fabricated into an anatomically correct undergarment structure for being positioned around a torso and residing directly against the skin of a hip spica cast patient. At least one fabric perineal panel is attached to the undergarment in the perineal area of the undergarment and adapted for being positioned on an overlying cast material defining a perineal opening in the cast.
US10893968B2 Orthotics having rate-responsive, stretchable devices
Rate-dependent, elastically-deformable devices according to various embodiments can be stretched and recovered at low elongation rates. Yet they become stiff and resistive to stretching at high elongation rates. These device can be utilized in orthotics, braces, and circulation-enhancing compression garments for the prevention of injury, promotion of personal health, and/or enhancement in human performance. The rate-responsive properties of the devices are critical performance enablers, as they allow the devices to provide a unique balance of comfort and performance that cannot be achieved with conventional, passive straps, braces, and compression garments.
US10893967B2 Technological congenital talipes equino varus (CTEV) treatment success rate improvement
Real-time cast sensor measurement outputs of a set of cast sensors that each measure a characteristic related to usage of an adjustable removable cast worn by a patient during treatment of congenital talipes equino varus (CTEV) are monitored. A cast usage anomaly relative to a treatment program prescribed for the patient with respect to wearing of the adjustable removable cast is identified according to the real-time cast sensor measurement outputs. Responsive to identifying the cast usage anomaly, real-time corrective treatment feedback is provided to the patient that instructs further and proper use of the adjustable removable cast to improve compliance with the treatment program prescribed for the patient.
US10893954B2 Curved spacer and inserter
The present teachings provide one or more surgical implements for repairing damaged tissue, such as in the case of a spinal fixation procedure. A cross connector system for use during a spinal fixation procedure is provided. The system includes at least one bridge defining a coupling bore and having a pair of downwardly extending arms for coupling to a first fastener. The system includes a contoured bar having a first end offset from a second end, and a bore having a central axis. The system includes an expansion ring received within the bore, and a locking device received through the expansion ring and the coupling bore. The locking device is operable in a first state in which the contoured bar is movable about the central axis of the bore and in a second state in which the contoured bar fixed relative to the central axis of the bore.
US10893952B2 Intervertebral fusion cage
An intervertebral fusion cage for the fusion of two vertebral bodies of the vertebral column comprises a first portion and a second portion opposite the first, both having a planar conformation axially elongated along a central axis. The first and the second portion have respective contact surfaces for receiving, in abutment, a respective vertebral body. The cage can also comprise a gripping area for connection with a positioning device. The first and the second portion are hinged to each other along a hinge axis so as to be able to rotate relatively in relation to each other with a continuous movement.
US10893951B2 Device and method for correcting spinal deformities in patients
Devices and related methods for the dynamic correction of spinal deformities are disclosed. The devices and methods are particularly useful for correcting an abnormal curvature of the spine. In one exemplary embodiment, a method for correcting deformity via a spinal implant that can include a polymer between or attached to a top and bottom plate, which can exist in a wedge-shaped configuration in order to apply asymmetric forces to the spinal column, is provided. The implant may be inserted between adjacent vertebrae comprising part of the abnormal curvature, thereby restoring the normal curvature of a spine.
US10893947B2 Femoral augments for use with knee joint prosthesis
A femoral augment, or set of augments, for use with a knee joint prosthesis, where the femoral augment includes a main body portion, an aperture formed within the main body portion and extending in a generally distal/proximal direction, and a pair of legs extending outwardly from said main body portion in a generally posterior direction. In the preferred embodiment, the aperture is configured to receive a stem extension implant, and to allow it to pass through. Additionally, the legs of the femoral augment are preferably configured to be seated proximal of a proximal side of a pair of condylar portions of a femoral component of a knee joint prosthesis. The present invention is intended for situations in which the distal portion of the femur is defective, and it provides a method and devices that allow for preservation of healthy peripheral bone, while still providing the necessary augmentation to the distal portion of the femur.
US10893942B2 Offset adapter unit
The present invention relates to an implant playing a role as a joint in coupling a revision implant in revision total knee arthroplasty and, more specifically, to an offset adapter unit comprising an adapter which couples a femoral member or a tibial member to a stem member in revision total knee arthroplasty; and a nut coupled to the adapter, thereby improving the strength by considering fracture occurring in the narrowest area.
US10893939B2 Controlled steering functionality for implant delivery tool
A catheter, advanced toward an anatomical site, has a proximal end and a steerable distal end. An anchor is advanced through the catheter. An anchor driver drives the anchor out of the catheter's distal end, anchoring the anchor at the site. A first constraining member engages tissue, and inhibits, after the anchor has been driven out of the catheter and before the anchoring, movement of at least the anchor driver's distal end, on a first axis between the anchor driver's distal end and a site at which the first constraining member engages the tissue. A second constraining member inhibits, after the anchor has been driven out of the catheter and before the anchoring, movement of at least the anchor driver's distal end, on a second axis. Other embodiments are also described.
US10893937B2 Magnet support of an implant
An implantable prosthesis, including an implantable component including an implantable magnet assembly, wherein the magnet assembly includes a magnet plated with a metallic substance, the magnet assembly includes a housing made at least in part of a polymer, wherein at least a portion of the housing made out of the polymer is in direct contact with the metallic substance, and the implantable component is configured to be implanted in a human such that the housing is exposed to body fluids thereof.
US10893935B2 Reducing breast implant weight using chemically produced foam filling
A method for manufacturing a breast implant including producing an elastic filler material including foam, by mixing a carbonate with a hydrolyzed silicone. A flexible shell, configured for implantation within a breast of a human subject, is filled with the elastic filler material.
US10893932B2 Implant and method for producing the same
An implant having a preferably hollow cylindrical basic structure. A nonwoven fabric is disposed in and/or on the basic structure, the nonwoven fabric preferably comprising biocompatible thermoplastic polyurethane and/or a polymer selected from the group consisting of polylactic acid, polycaprolactone, and a copolymer thereof, and/or a polymer including polyphosphazene. At least in at least one section of the implant, preferably at the proximal and/or distal ends of the implant, fastening means are provided or the nonwoven fabric is treated such that, at least in the expanded state of the implant, the protrusion of nonwoven fabric sections from the implant is significantly reduced. Furthermore, a method for producing such an implant is provided.
US10893931B2 Strong, flexible, and thrombus-free woven nanotextile based vascular grafts, and method of production thereof
An apparatus for fabrication of a woven tubular nanotextile used in vascular graft applications. The woven nanotextile conduit is 0.1 to 50 mm in diameter and includes a multitude of hierarchically arranged nanofibers. They are made from low strength bundled nanoyarns containing thousands of nanofibers with improved mechanical strength. The weaving apparatus interweaves the warp and weft yarns in longitudinal and transverse directions, resulting in a flexible and strong woven product. The physical and biological properties of the woven nanotextile were significantly enhanced when compared to non-woven nanofibrous form and conventional medical textiles. The nanotextile displayed superhydrophilic behavior in an otherwise hydrophobic material and when implanted as a vascular graft was robust, suturable, kink-proof and non-thrombogenic, with complete endothelialization of the graft luminal area.
US10893928B2 Decellularized biologically-engineered tubular grafts
This disclosure describes decellularized, biologically-engineered tubular grafts and methods of making and using such decellularized, biologically-engineered tubular grafts.
US10893921B2 Method of making a denture with nature bite and wear properties and denture
The present invention to a method of denture manufacture that incorporates CAM-formed occlusal portions made of zirconia, resulting in a natural fit, feel, and wear essentially similar to the wear properties of natural teeth.
US10893918B2 Determining a dental treatment difficulty
Embodiments for determining a dental treatment difficulty are described herein. One method embodiment includes receiving an initial and subsequent position of each of a first tooth and a second tooth and calculating a change in position of each of the first tooth and the second tooth. The method embodiment can also include projecting the changes in position of each of the first tooth and the second tooth onto a reference line and calculating a change in position on the reference line for the first tooth and the second tooth. The method embodiment can further include determining the dental treatment difficulty based on the changes in position on the reference line.
US10893914B2 Surgical instrument with dual mode end effector and modular clamp arm assembly
A first subassembly includes a body and an ultrasonic blade. A second subassembly is configured to removably couple with the first subassembly and includes a first clamp arm and a first clamp arm actuator. The first clamp arm is configured to be located on a first side of the longitudinal axis of the body, and the first clamp arm actuator is configured to be located on a second side of the longitudinal axis, when the second subassembly is coupled with the first subassembly. The third subassembly is similar to the second subassembly except that the second clamp arm of the third subassembly is configured to be located on the second side of the longitudinal axis of the body when the third subassembly is coupled with the first subassembly.
US10893912B2 Surgical tool systems and methods
Embodiments of the present disclosure provide a surgical robot system may include an end-effector element configured for controlled movement and positioning and tracking of surgical instruments and objects relative to an image of a patient's anatomical structure. In some embodiments the end-effector may be tracked by surgical robot system and displayed to a user. In some embodiments the end-effector element may be configured to restrict the movement of an instrument assembly in a guide tube. In some embodiments, the end-effector may contain structures to allow for magnetic coupling to a robot arm and/or wireless powering of the end-effector element. In some embodiments, tracking of a target anatomical structure and objects, both in a navigation space and an image space, may be provided by a dynamic reference base located at a position away from the target anatomical structure.
US10893908B2 Medical devices and methods incorporating frustrated total internal reflection for energy-efficient sealing and cutting of tissue using light energy
A medical instrument includes two jaw members, at least one of which creates conditions of frustrated total internal reflection at a tissue-contacting surface when tissue is grasped between the two jaw members. The first jaw member may include an optical element having a tissue-contacting surface. The medical instrument also includes a light source that provides a light beam for sealing tissue. The light source is positioned so that the light beam is totally internally reflected from an interface between the tissue-contacting surface and air when tissue is not grasped by the jaw members. When tissue is grasped by the jaw members, at least a portion of the light beam is transmitted through that portion of the tissue-contacting surface that is in contact with the tissue. The light source may be movably coupled to a jaw member to scan the light beam and/or to change the incident angle based on optical properties of the tissue.
US10893905B2 Systems, apparatuses, and methods for ventricular focal ablation
Systems, devices, and methods for electroporation ablation therapy are disclosed, with the system including a pulse waveform signal generator for medical ablation therapy, and an endocardial ablation device includes an inflatable member and at least one electrode for focal ablation pulse delivery to tissue. The signal generator may deliver voltage pulses to the ablation device in the form of a pulse waveform. The system may include a cardiac stimulator for generation of pacing signals and for sequenced delivery of pulse waveforms in synchrony with the pacing signal.
US10893903B2 Medical instruments having contact assessment features
Systems and methods for facilitating assessment of a nature of contact between an electrode assembly of an ablation catheter and viable body tissue are disclosed herein. In some embodiments, a method comprises obtaining a first detected voltage between a first electrode and a second electrode, wherein the first and second electrodes are positioned along an electrode assembly of the ablation catheter, and wherein the first electrode is distal to the second electrode, obtaining a second detected voltage between the second electrode and a third electrode, the third electrode positioned proximal to the second electrode.
US10893901B2 Surgical instrument with dispensable components
A surgical instrument includes an active electrode coupled to a source of electrosurgical energy. The active electrode includes a tissue-contacting surface on an exterior surface of the instrument such that the tissue-contacting surface of the active electrode may intimately engage tissue. A replacement electrode includes a tissue-contacting surface, and is located in an interior cavity of the instrument. A seal is formed between the active electrode and the interior cavity of the instrument such that the tissue-contacting-surface of the replacement electrode is isolated from contamination exposed to the exterior of the instrument. The active electrode is removable from the instrument to expose the tissue-contacting surface of the replacement electrode, and the replacement electrode is connectable to the source of electrosurgical energy when the active electrode is removed.
US10893897B2 Orthopedic fastener
An orthopedic fastener has a head and a shank. The shank has a leading end portion adjacent a distal tip and a trailing end portion adjacent a head. An intermediate portion is positioned between the leading and trailing end portions. At the intermediate portion, the shank increases in diameter. The leading end portion has a first thread which includes one or more self-tapping cutting grooves extending adjacent the distal tip and through a plurality of the first threads. The intermediate portion has second threads extending toward the head from the leading end portion. The second threads of the intermediate portion are larger in outer diameter than the first threads in the leading end portion. The intermediate portion has one or more cutting grooves traversing at each of a leading transition at the leading end portion and at a trailing transition.
US10893896B2 Cranioplasty plate assembly with pivotal struts
An adjustable cranioplasty plate assembly is provided for use following a craniectomy. The assembly includes a ring which is attached to the skull around the skull opening and a plate adjustably mounted to the ring. The plate is moveable between a raised position spaced above the ring and a lower position substantially flush with the ring. The plurality of extendable and retractable struts extends between the ring and the plate to provide the plate adjustability. The plurality of stay cables extending between the ring and the plate provide lateral stability in the raised position. The assembly replaces the native bone and eliminates the need for subsequent cranioplasty surgery. In one embodiment, the plate includes a rigid central portion, three rigid mounting tabs, and a plurality of malleable tapered perimeter petals which provide a smooth interface between the plate and the skull of the patient.
US10893895B2 Minimally invasive screw extension assembly
A screw extension assembly for use in minimally invasive spinal surgery, the assembly has an inner slotted shaft and an outer shaft, a rod reducer and a removable nut. The combination when assembled is configured to move a spinal fixation rod into a slotted rod receiving spinal implant where it is seated and affixed thereto. The screw extension assembly further has a locking knob rotationally coupled to a proximal end of the outer shaft, wherein the inner shaft has one or more cam grooves and the locking knob has a pin extending into and guided by said cam groove causing the outer shaft to translate longitudinally upon rotation of the locking knob relative to the inner shaft toward an engaged position locking the deflectable legs in the coupled position to the slotted rod receiving implant.
US10893894B2 Transverse coupling for surgical implant extensions
A transverse coupling for connecting multiple implant extensions includes at least a first sleeve and a second sleeve. The first sleeve defines a first aperture adapted to axially receive a first implant extension through the first aperture. The second sleeve defines a second aperture adapted to axially receive a second implant extension through the second aperture. The transverse coupling also includes a central housing. A first shaft connects the first sleeve to the central housing, and a second shaft connects the second sleeve to the central housing. The central housing includes at least one joint for connecting the central housing to at least one of the first and second shafts in a movable arrangement that allows the shaft(s) to move through one or more degrees of freedom relative to the central housing.
US10893893B2 Intervertebral implant devices and methods for insertion thereof
An implant device is provided that is configured for implantation at multiple locations between adjacent vertebrae. The implant device comprises an implant body, a first portion of the implant body, and a second portion of the implant body adjustably interconnected with the first portion. The implant body has a compact orientation and an extended orientation to allow the implant body to be shifted from one orientation to the other orientation for being positioned in any one of areas between the spinous processes of the adjacent vertebrae, between laminar regions of the adjacent vertebrae, spanning an opening in the annulus between the adjacent vertebrae, and in the intervertebral space between the adjacent vertebrae.
US10893890B2 Polyaxial bone fixation assembly
A polyaxial bone fastener assembly (1) comprising a plate (2) with at least one through orifice (3), and at least one fastener screw (4) for fastening the plate (2) to a bone, the body (6) of the screw (4) being suitable for passing through the orifice (3), and its head (5) being suitable for being retained in the orifice (3) of the plate (2) by bearing contact between complementary male and female spherical surfaces (7, 8), the female spherical surface (8) that is arranged in the orifice (3) of the plate (2) forming a seat within which the male spherical surface (7) is suitable for coming to bear when the screw (4) is inserted in the orifice (3).On going from the bottom face (22) towards the top face (21) of the plate (2), the bore of the orifice (3) in the plate (2) comprises: an inner collar (9); a cylindrical portion (10); and the seat-forming female spherical surface (8); and on going between its male spherical surface (7) and its zone (11) connecting to the body (6) of the screw (4), the head (5) of the associated fastener screw (4) has a threaded portion (12) with a single-start thread, the thread being interrupted in at least two zones (13) in order to enable the inner collar (9) of the orifice (3) in the associated plate (2) to be machined while the screw (4) is being driven to turn inside said orifice (3) until it reaches a position of bearing contact between the male and female spherical surfaces (7, 8).
US10893888B2 Spinal implant system and method
A spinal construct comprises a member extending between a first end and a second end and includes a first layer and a second layer. The first layer includes a plurality of interlaced strands that define a first angle. The second layer includes a plurality of interlaced strands that define a second angle. The first angle is smaller than the second angle. Systems, implants, surgical instruments and methods are disclosed.
US10893887B2 Intraosseous access device
An access device configured for inserting an intraosseous catheter into an interior portion of a bone is disclosed. In one embodiment, an intraosseous access device is disclosed, comprising a device body, a trocar needle included with the device body, and an intraosseous catheter removably disposed on the trocar needle. The device body is configured to enable a user of the access device to manually insert a distal tip of the trocar needle through a skin surface of a body of a patient to an external surface of a bone of the patient. An advancement mechanism is also disclosed and is configured to selectively and distally advance the trocar needle and intraosseous catheter a predetermined distance into an internal portion of the bone of the patient after the distal tip of the trocar needle has been inserted to the external surface of the bone.
US10893881B2 Method and apparatus for accelerated disintegration of blood clot
Systems and methods for treating a blood clot include a catheter to be inserted into a patient. The catheter is used to deliver low stability microbubbles toward the blood clot in the patient. A thrombolytic agent is delivered toward the blood clot, and ultrasonic energy is applied to the microbubbles to vibrate the microbubbles.
US10893879B2 Patient-specific knee alignment guide and associated method
A method of preparing a knee joint for a prosthesis in a patient includes mating a patient-specific three-dimensional curved inner surface of a femoral alignment guide onto a corresponding three-dimensional femoral joint surface of the patient. The patient-specific three-dimensional curved inner surface is preoperatively configured from medical scans of the knee joint of the patient. First and second holes are drilled into an anterior portion of the femoral joint surface through corresponding first and second guiding apertures of the femoral alignment guide.
US10893877B2 Guided punch for talar augments
A guided punch is disclosed. The guided punch generally comprises a strike cap comprising a strike surface, a punch comprising a distal cutting edge, and a guide rod. The strike cap defines a first cavity therein. The punch defines a second cavity therein in communication with the first cavity. The guide rod is located within the first and second cavities and extends a predetermined distance beyond the distal cutting edge of the punch. The strike cap and the punch are moveable relative to the guide rod.
US10893876B2 Method and apparatus for manufacturing an implant
An orthopedic device includes a femoral implant having a non-custom internal bone engagement surface. The femoral implant includes at least nine parameters adjusted preoperatively to correspond to a specific patient. The parameters can include patient-specific lengths, such as, for example, medial and lateral condyle widths and notch height, and patient-specific medial and lateral angles.
US10893875B2 Apparatus to access bone marrow
A penetrator assembly operable to provide access to a bone marrow is provided. The penetrator assembly may include an outer penetrator and a removable inner trocar operable to penetrate bone and bone marrow. The removable inner trocar may include a groove operable to receive a portion of the bone and bone marrow when the outer penetrator and the removable inner trocar penetrate the bone and bone marrow. The removable inner trocar may include a receptacle operable to receive a portion of a connector operable to releasably attach the penetrator assembly to a powered apparatus, and a release mechanism disposed within the receptacle and operable to engage the portion of the connector.
US10893874B2 Instruments and methods for preparing a bone to receive a prosthesis
A method of resecting an end of bone comprising inserting a cutting guide having a guide surface into a void in an end of bone such that the guide surface is beneath an end surface of the bone, and resecting the bone along the guide surface while the cutting guide remains disposed within the void in the end of the bone.
US10893871B2 Tourniquet safety sleeve
A sleeve for use with a tourniquet cuff to protect a patient's limb from tourniquet-related injury includes a stretchable body extending longitudinally over a sleeve length between a proximal end and a distal end. The body has a tubular shape, and the sleeve length is greater than a width of the tourniquet cuff. The body tapers from the proximal end to the distal end such that a proximal end circumference is greater than a distal end circumference. The body is formed to apply substantially uniform pressure to the patient's limb from the proximal end of the sleeve to the distal end of the sleeve varying only within a predetermined pressure range.
US10893864B2 Staple cartridges and arrangements of staples and staple cavities therein
A staple cartridge is disclosed. The staple cartridge can include a cartridge body having a plurality of staple cavities defined therein. The staple cavities can be obliquely oriented relative to a longitudinal axis of the staple cartridge. The staple cavities can be arranged in a plurality of rows including an inner row, an intermediate row, and an outer row. The lateral and/or longitudinal spacing and/or overlap between the staples in adjacent rows can vary to optimize the flexibility and/or sealing properties of the staple line. The size and orientation of the staples can also vary row-to-row and/or longitudinally.
US10893862B2 Surgical staple implant kit
An apparatus and a method are provided for a sterile staple implant kit that a surgeon may unpack and utilize during a surgery. The staple implant kit comprises a group of complementary surgery-specific instruments that are packaged in a sterile state. An instrument tray is configured to preserve the instruments in the sterile state until the staple implant kit is opened during the surgery. The instrument tray is configured to provide the surgeon with easy access to the instruments during the surgery. The staple implant kit comprises at least a staple inserter and a surgical staple suitable for being implanted in parallel holes drilled across a bone fusion or fixation site of a patient. The surgical staple preferably is loaded in a relaxed configuration into the staple inserter. A staple retention clip retains the surgical staple in the staple inserter until the staple is distracted during the surgery.
US10893861B2 Surgical port for stay sutures
A surgical port is disclosed. The surgical port has a multi-level flange defining one or more suture channels therethrough. Adjacent levels of the multi-level flange are configured to pinch one or more sutures placed therebetween. The surgical port also has a cannular frame defining one or more cannular channels in communication with the one or more suture channels.
US10893857B2 Method and apparatus for coupling soft tissue to bone
A method and apparatus for securing a suture to bone can include grasping a first suture portion with a grasping member on a positioning tool. The first suture portion can be located into a first cannulation defined in the positioning tool. A cutting member can be advanced through a second cannulation defined on the positioning tool and out through a distal opening defined on the positioning tool. A first bone hole can be cut into the bone with the cutting member. A flexible member advancing tool can be advanced through the first cannulation. The first suture portion can be urged out of the distal opening and into the first bone hole.
US10893854B2 Biomedical device for watertight sealing of an opening
Disclosed is a biomedical device being introduced by a hollow tube having a longitudinal axis in a subject in a minimally invasive surgery procedure for watertight sealing of an opening including at least two assemblies, each assembly including one flap connected to one arm, the arm having an longitudinal axis; the assemblies including a delivery configuration, a deployed configuration, and a sealed configuration and outwards deployment unit for switching from the delivery configuration to the deployed configuration and inwards deployment unit for switching from the deployed configuration to the sealed configuration. Also disclosed is a kit of parts including an outer hollow tube, an inner hollow tube, and a related biomedical device.
US10893851B2 System and method for motion compensation in medical procedures
A system for fusing images to account for motion compensation includes an imaging modality configured to obtain a baseline image and current images. A live tracking system is configured to track an imaging instrument for capturing the baseline image and the current images, the live tracking system having a coordinate system registered with the baseline image and the current images. A pose analyzer unit is configured to employ field of view differences between a pose for the baseline image and a pose for a current view image using the live tracking system to generate success parameters. The success parameters are conveyed to the user to provide feedback on image acquisition for motion compensation between the baseline image and the current view image.
US10893850B2 Methods and apparatuses for guiding collection of ultrasound data using motion and/or orientation data
Aspects of technology described herein relate to guiding collection of ultrasound data collection using motion and/or orientation data. A directional indicator corresponding to an instruction for moving an ultrasound imaging device relative to a subject may be displayed in an augmented reality display. The direction of the directional indicator in the augmented reality display may be independent of an orientation of the ultrasound imaging device. The augmented reality display may include video captured by a camera that depicts the ultrasound imaging device and a fiducial marker on the ultrasound imaging device. The direction of the directional indicator may be based on the pose of the camera relative to the fiducial marker and the rotation and/or tilt of the ultrasound imaging device relative to the axis of gravity. The direction of the directional indicator may also be based on the pose of the camera relative to the subject.
US10893848B2 Ultrasound diagnosis apparatus and image processing apparatus
An ultrasound diagnosis apparatus includes filter coefficient acquiring circuitry configured to, based on a result of a principal component analysis using first data strings that are sets of data generated based on echo signals caused by transmission of ultrasound waves on the same scan line, obtain a filter coefficient that suppresses clutter components; deriving circuitry configured to use the filter coefficient to obtain, from target data strings contained in a region of interest among the first data strings, a second data string that is a set of data derived from echo signals based on a moving body present in the region of interest, and derive waveform information indicating temporal changes of the moving body by performing a frequency analysis on the second data string; and control circuitry configured to generate a waveform information image based on the wave information and cause a monitor to display the waveform information image.
US10893847B2 Transcatheter insertion system
A transcatheter insertion system is provided for the insertion of an intracorporeal device using an insertion device. The system comprises an outer sheath arranged and configured to form a passageway for the intracorporeal device and/or the insertion device. The outer sheath guides the insertion device. A method of transcatheter insertion with the system is also provided.
US10893846B2 Ultrasound diagnosis apparatus
An ultrasound diagnosis apparatus generates an ultrasound image of an inside of a subject on a basis of ultrasound signals which are reflected off at the inside of the subject and received. The apparatus includes a needle position specifier and a needle emphasis processor. With respect to each region in the ultrasound image, the needle position specifier obtains a deep region feature value relating to signal intensity in a region deeper than a region subject to judgment in relation to ultrasound signal distribution along an emission direction of an ultrasound emitted in a subject, and specifies a position of a puncture-needle which is inserted in the subject. The needle emphasis processor carries out a process for emphasizing the position of the puncture-needle which is specified in the ultrasound image.
US10893840B2 X-ray diagnostic apparatus
According to one embodiment, an X-ray diagnostic apparatus includes a holding device and processing circuitry. The holding device movably holds an X-ray generator and an X-ray detector. The processing circuitry generates an X-ray image of the subject, based on an output of the X-ray detector. The processing circuitry sets an interference judgment region between the holding device and an interference object, based on a landmark in the X-ray image. The processing circuitry controls movement of the holding device, based on the set interference judgment region.
US10893838B2 Medical imaging system having an array of distributed X-ray generators
The disclosed system includes an emitter array for generating x-rays, a detector array for sensing a flux of x-rays transmitted through a region of interest; apparatus for holding, moving and aligning the emitter array relative to the region of interest and the detector array; electronic means for controlling the emitters and for reading and analyzing the output from the detectors and converting it to image data, and a display for displaying and manipulating the image data. The individual emitters are operated in multiple groups each illuminating a region of interest between the emitter array and the detector array such that the cone of radiation rays projected on the detector array from any single emitter in any one such group is substantially spatially separated from the corresponding projected cones from all other emitters in that same group.
US10893837B2 Simultaneous multi-parameter physiological monitoring device with local and remote analytical capability
Handheld medical diagnostic instrument that provides high time-resolution pulse waveforms associated with multiple parameters including blood pressure measurements, blood oxygen saturation levels, electrocardiograph (ECG) measurements, and temperature measurements. The device stores and analyzes the pulse waveforms simultaneously obtained from all tests, and thereby allows an unusually detailed view into the functioning of the user's cardiovascular heart-lung system. The device is designed for use by unskilled or semi-skilled users, thus enabling sophisticated cardiovascular measurements to be obtained in a home environment. Data from the device can be analyzed onboard, with local computerized devices, and/or with remote server based systems. The device or remote server may be configured to analyze this data according to various algorithms chosen by the physician to be most appropriate to that patient's particular medical condition (e.g. COPD patient algorithms). The device or remote server may be further configured to automatically provide alerts and drug recommendations.
US10893834B2 Charger for pressure sensing catheter
A charger for charging a pressure sensing catheter is provided. The charger can include a plurality of charging ports for receiving a portion of the proximal section of the pressure sensing catheter. The charging port may include an engagement portion for engaging with the portion of the proximal section of the pressure sensing catheter such that when the engagement portion engages with the proximal section of the pressure sensing catheter, the engagement portion is fluidly coupled to the catheter lumen and the pressure transmission medium from the engagement portion is displaced from the engagement portion to charge the one or more balloons of the pressure sensing catheter. The charger can include a cover for covering the engagement portion. The charger can include flutes defined on a surface of each charging port to permit a predetermined volume of the pressure transmission medium to be displaced from each charging port.
US10893826B2 Electronic caliper for assessing patient biomechanics
A system for displaying and collecting biomechanical measurements is provided. The system comprises: an electronic caliper including a bar, two arms slidably mounted on the bar and extending normal therefrom, a display module, and an electronic system housed in the display module and comprising a light emitting diode string of lights, a nine-axis sensor, firmware, a wireless radio, and a power source connector for electronic communication with a power source; and a remote computing device, the wireless radio in communication with the remote computing device. The electronic caliper and method of use thereof is also provided.
US10893822B2 Method and system for use in monitoring neural activity in a subject's brain
A system and method are presented for use in monitoring brain activity of a subject. The system comprises a control unit which comprises: a data input utility for receiving measured data comprising data corresponding to signals measured during a certain time period and being indicative of a subject's brain activity originated from locations in the subject's brain during said certain time period, and a processor utility which is configured and operable for processing the measured data and generating data indicative thereof in the form of a multi-parameter function presenting a relation between frequency and time data of the measured signals and for analyzing said relation and identifying a subject-related signature corresponding to the subject's brain neural activity.
US10893821B2 Electrode assemblies and electroencephalographic devices, methods and kits
In accordance with at least one aspect of this disclosure, an encephalographic electrode assembly can include a wicking element that has a wick body, one or more long legs extending from the wick body and inserted into the one or more hollow contact probes, and one or more short legs, which are shorter than the long legs, extending from the wick body and inserted into the one or more short reservoir sleeves. The short legs are configured to prevent slide-out of the wicking element from the reservoir body.
US10893819B2 Analyzing and mapping ECG signals and determining ablation points to eliminate Brugada syndrome
A system and method for Brugada syndrome epicardial ablation comprising preparing an endocardial duration map; preparing a baseline epicardial duration map comprising at least one or more areas of delimination; and when some of the areas of delimination are greater than 200 ms, performing epicardial ablation of the areas of delimination greater than 200 ms. The method may further comprise preparing an updated epicardial duration map after performing epicardial ablation, and determining whether or not a BrS pattern appears in the updated epicardial duration map; and when the BrS pattern appears, performing epicardial ablation. The method may further comprise preparing an updated epicardial duration map after performing epicardial ablation, and determining whether or not an abnormal EGM exists in the updated epicardial duration map; and when the abnormal EGM exists, performing epicardial ablation. The method may further comprise preparing an updated epicardial map comprising maintaining anatomical volume data and adding electroanatomical data.
US10893814B2 System and method for obtaining vital sign related information of a living being
The present invention relates to a device, system and method for obtaining vital sign related information of a living being. The proposed device comprises an input unit for receiving an input signal generated from light received in at least one wavelength interval reflected from a skin region of a living being, said input signal representing vital sign related information from which a vital sign of the living being can be derived, a processing unit for processing the input signal and deriving vital sign related information of said living being from said input signal, an orientation estimation unit for estimating the orientation of said skin region, and a control unit for controlling an illumination unit for illuminating said skin region with light to illuminate said skin region based on the estimated orientation of said skin region and/or for controlling said processing unit to derive vital sign related information from said input signal obtained during time intervals selected based on the estimated orientation of said skin region.
US10893813B2 Heart failure management
Various system embodiments comprise a stimulator adapted to deliver a stimulation signal for a heart failure therapy, a number of sensors adapted to provide at least a first measurement of a heart failure status and a second measurement of the heart failure status, and a controller. The controller is connected to the stimulator and to the number of sensors. The controller is adapted to use the first and second measurements to create a heart failure status index, and control the stimulator to modulate the signal using the index. Other aspects and embodiments are provided herein.
US10893811B2 System and method for monitoring cardiorespiratory parameters
An apparatus, system, and method is disclosed for monitoring the motion, breathing, heart rate of humans in a convenient and low-cost fashion, and for deriving and displaying useful measurements of cardiorespiratory performance from the measured signals. The motion, breathing, and heart rate signals are obtained through a processing applied to a raw signal obtained in a non-contact fashion, typically using a radio-frequency sensor. Processing into separate cardiac and respiratory components is described. The heart rate can be determined by using either spectral or time-domain processing. The respiratory rate can be calculated using spectral analysis. Processing to derive the heart rate, respiratory sinus arrhythmia, or a ventilatory threshold parameter using the system is described. The sensor, processing, and display can be incorporated in a single device which can be worn or held close to the body while exercising (e.g., in a wristwatch or mobile phone configuration), or alternately placed in a fixed piece of exercise equipment at some distance form the body (e.g., in a treadmill dash panel), and may also be integrated with other sensors, such as position locators.
US10893804B2 Measurement of intraocular pressure
A system for measuring intraocular pressure in an eye of a patient includes a sensor configured to be positioned in the eye of the patient. The sensor includes a sealed cavity, and a flexible membrane sealing a distal end of the sealed cavity, the flexible membrane configured to deflect responsive to the intraocular pressure in the eye of the patient. The system includes a detection device configured to be positioned external to the eye of the patient and optically coupled to the sensor, the detection device configured to detect an indication of change in length of the sealed cavity resulting from deflection of the flexible membrane.
US10893801B2 Eye tracking system and method to detect the dominant eye
The invention relates to an eye tracking system (10) and a method for operating an eye tracking system (10) for determining if one of a left and a right eye of a user is dominant, wherein at least one image of the left and the right eye of the user is captured (S30), based on the at least one image and according to a predefined accuracy function a left accuracy score for the left eye (S34a) and a right accuracy score for the right eye (S34c) is determined and it is determined if one of the left and the right eye of the user is dominant in dependency of at least the left and the right accuracy score (S36). Thereby user-specific properties relating to his eyes can be provided and considered when performing eye tracking so that the robustness and accuracy of eye tracking can be enhanced.
US10893799B2 Method for determining the topography of the cornea of an eye
A method for determining the topography of the cornea of an eye on the basis of an optical, contactless data capture. In the method for determining the topography of the cornea of an eye, which is based on a deflectometric method, the deflectometric measurements are carried out with the aid of a keratometric method by virtue of additional OCT-based scans being made at the keratometric measurement points, wherein the two measurement systems are registered to one another and both the keratometric and the OCT-based measurement values are recorded and used for mutual calibration to determine and output the topographic data. The proposed method serves to determine the topography of the cornea of an eye. It is helpful to ascertain the topography in order to be able to draw conclusions about possible pathological changes. Moreover, the exact measurement of the corneal topography is of great importance for correcting refractive errors.
US10893797B2 User interface for efficiently displaying relevant OCT imaging data
The present invention is an OCT imaging system user interface for efficiently providing relevant image displays to the user. These displays are used during image acquisition to align patients and verify acquisition image quality. During image analysis, these displays indicate positional relationships between displayed data images, automatically display suspicious analysis, automatically display diagnostic data, simultaneously display similar data from multiple visits, improve access to archived data, and provide other improvements for efficient data presentation of relevant information.
US10893794B2 Steerable endoscope and improved method of insertion
A system for advancing an instrument along an arbitrary path includes a flexible and steerable instrument and an electronic memory configured to store a three-dimensional model of the path, the three-dimension model being generated based on signals from the instrument as it traverses along the path. The system further includes an electronic motion controller logically coupled to the electronic memory, wherein the electronic motion controller is configured to automatically control the instrument to traverse the path based on the three dimensional model.
US10893793B2 Objective optical system and endoscope device including the same
An objective optical system includes a lens group and an optical path splitting element. The optical path splitting element is disposed on an optical path of the lens group, the optical path splitting element includes an optical path splitting surface configured to form a first optical path and a second optical path, an optical path length in the first optical path is different from an optical path length in the second optical path, a sum total of the number of transmissions of light and the number of reflections of light in the second optical path is larger than a sum total of the number of transmissions of light and the number of reflections of light in the first optical path, and an optical surface satisfying following conditional expression (1) is disposed on the first optical path, 0.8≤MR650/MR550≤0.9  (1).
US10893789B2 Laminated foam mophead
A laminated foam mop head which includes a foam block having a top surface, a bottom surface, and two side surfaces, a fabric material laminated to the bottom and side surfaces of the foam block, and a bracket attached to the top surface of the foam block such that the bottom and side surfaces of the foam block are drawn upward and inward to form a mop head having an elliptical shaped cross section and the top surface of the foam block is pushed inward and not exposed.
US10893788B1 Mobile floor-cleaning robot with floor-type detection
Cleaning robots may use floor-type-detection techniques as a trigger for autonomously altering various floor-cleaning characteristics. In some examples, a controller circuit of the robot is configured to determine a flooring type as a function of a signal from a motion sensor indicative of a change in pitch caused by the robot crossing a flooring discontinuity. In some examples, the controller circuit is configured to determine a flooring type based on a power draw signal corresponding to the cleaning head assembly of the robot.
US10893787B2 Remote control scheduler and method for autonomous robotic device
A method of scheduling a robotic device enables the device to run autonomously based on previously loaded scheduling information. The method consists of a communication device, such as a hand-held remote device, that can directly control the robotic device, or load scheduling information into the robotic device such that it will carry out a defined task at the desired time without the need for farther external control. The communication device can also be configured to load a scheduling application program into an existing robotic device, such that the robotic device can receive and implement scheduling information from a user.
US10893775B2 Blender container with latch release
A system for attaching a blender container to a blade assembly, which comprises a first mechanism to secure a blender container to a blade assembly. Some embodiments of the system include a second latch mechanism to lock the blender container to the blade assembly while the container and blade assembly are mounted to a base for operation of the blender.
US10893772B2 Infusion extracting apparatus and method
An extraction apparatus and methods for making and using the same are disclosed. The apparatus includes a cylindrical container with lid and pour spout, a container insert, and a plunger including a piston, a rod, a handle, and a filter or filtration chamber. The container insert is designed to catch infusible material which may be easily removed from the container when the container is empty or when the extract fluid remains in the container. The plunger may temporarily couple with the insert to allow the insert to be pulled up through the container with the grounds of other infusible material captured between the insert and the plunger allowing for quick and easy cleanup. The extraction apparatus is adapted for a use in a variety of sizes and may be adapted for manufactured at low cost. A variety of embodiments and alternatives are also included in the disclosure.
US10893764B2 Paper cup provided with heat conduction prevention plate
The present invention relates to a paper cup provided with a heat conduction prevention plate. The paper cup is provided integrally with a heat conduction prevention plate by being attached to the paper cup, and thus it is not necessary for a user to frequently insert a separate heat conduction prevention plate into the paper cup when drinking a drink. Also, a certain space is formed between the integrated heat conduction prevention plate and the paper cup body, thereby effectively performing a heat conduction blocking function. Moreover, since the heat conduction prevention plate is provided in an area that can be held by a finger, it is possible to be manufactured at a low manufacturing cost, and the paper cup widens toward the top, so that the paper cup slips less from fingers.
US10893760B2 Frame configured to easily replace exhibit
Provided is a frame configured to easily replace an exhibit in the case where an exhibition location for a print is a magnetic material, such as a metallic plate, a wall surface of a building composed of a magnetic board or sandwich panel. A wide and thin rubber magnet plate and another rubber magnet plate thicker than the thin rubber magnet plate are cut into predetermined shapes, and a freely bendable thin transparent film is attached to the surface of the thick rubber magnet opposite to the magnet with an adhesive in the state of covering the outer periphery of the magnet plate, so that a space is secured between the thin rubber magnet plate and the film.
US10893758B2 Shelving system using shutters
A shelving system includes a dispensing module including a shutter and a track. The shutter is movable on the track. The shutter is associated with a motor, a connecting mechanism to control connection of the shutter and the motor, and a controller to control location of the shutter using the motor. The system further includes a control module including a user interface device and a control device to communicate with the dispensing module for dispensing an item.
US10893753B2 Apparatus with weight responsive changeable adjusting characteristics
A reconfigurable apparatus for seating a user and having: a frame; a seat movable relative to the frame between: a) a first position in which the seat resides with no user sitting on the seat; and b) a loaded position; a back rest with a changeable angular orientation relative to the frame; and an adjusting assembly having a plurality of gears that move relative to each other as an incident of the seat moving from the first position into the loaded position to thereby cause an increase in resistance to changing of the angular orientation of the back rest.
US10893748B1 Height adjustable desktop
A height adjustable desktop includes an upper work surface platform, and a base platform, which configured to rest on an existing desk, platform, surface, or table. The height adjustable desktop further includes a height adjustment mechanism that includes two sets of two arms that connect at pivot points along their lengths so that the arms configured to move in a scissoring motion to raise and lower the upper work surface platform. The height adjustable desktop also includes two actuators that apply a force to the two sets of two arms, the actuators each containing feedback sensors that provide data regarding the current position and distance each actuator has extended, retracted or moved.
US10893747B1 Modular table and assembly
A furniture item comprises first and second edge modules, each edge module having a substantially horizontal component with a receiving section and a substantially vertical component with a receiving section. The first and second edge modules are spaced and arranged with respect to each other so that the respective receiving section of the horizontal components face each other. A top surface is provided and has first and second ends. The first end is supported by the receiving section of the horizontal component of one first edge module and the second end is supported by the receiving section of the horizontal component of the second edge module. Further, there is a first leg having an upper section accommodated by the receiving section of the vertical component of the first edge module and a second leg having an upper section accommodated by the receiving section of the vertical component of the second edge module.
US10893741B1 Bulletproof bag
Disclosed herein is a bulletproof bag. A bulletproof bag according to one embodiment of the present invention includes: a frame which supports the rear side of a bag; a body which is coupled to the outside of the frame and forms an accommodation space; shoulder straps which are coupled to the body and worn on the shoulders of a user; a zipper part which extends from both sides of the bottom of the body to the center of the bottom of the body and extends along the center portion of the outer side of the body; and string guide holders which guide strings through their movement; wherein when ends of the strings are pulled, the sliders of the zipper part are moved, the zipper part is opened, and finally the body is changed into a state of being able to be worn to protect the user.
US10893740B2 Color conversion system and method
A method is provided for preparing a hair dye color mixture. The method includes: accessing a control system having at least a processor, a memory, and user input controls, the memory configured to store ingredients of a hair dye color mixture, each ingredient of the hair dye color mixture being from an initial product brand; receiving user input from the user input controls to change one or more ingredients of the hair dye color mixture from the initial product brand to one or more subsequent product brands; matching the color of the hair dye color mixture made from one or more ingredients of the initial product brand using one or more ingredients of the one or more subsequent product brands, in response to the user input; and displaying the ingredients of the hair dye color mixture in the one or more subsequent product brands on a display.
US10893736B2 Drawing apparatus and drawing method
A drawing apparatus includes a drawing head and a control device. If a drawing target surface has a first region acclivitous and declivitous respectively in first and second directions different from one another, the drawing head draws first pixels to be drawn on the first region while performing first and second scans in which the drawing head moves respectively in the first and second directions. The control device controls a ratio of a drawing amount of a first scan drawing pixel to be drawn in a line of the first region during the first scan to a drawing amount required for pixels in the line among the first pixels to be higher than a ratio of a drawing amount of a second scan drawing pixel to be drawn in the line during the second scan to the drawing amount required for the pixels in the line.
US10893727B2 Faceted gemstone with enhanced color dispersion and diminished haze
Incident light enters a faceted gemstone and is routed along optical paths to exit the gemstone as emergent light. At least one diffraction grating is patterned on the gemstone in an asymmetrical manner relative to an axis of symmetry. The diffraction grating has a diffractive structure positioned on at least one facet for diffracting the light being routed along at least one of the optical paths to enhance color dispersion of the emergent light. The diffraction grating is the only diffraction grating to diffract the light being routed along the at least one optical path to diminish haze of the emergent light.
US10893725B1 Customizable wristband
Rubber silicone bracelets are a popular type of wristband worn today; however, they lack in both customization of content as well as size. The biggest problem with current wristbands is that they are designed for a single cause and are manufactured to represent one specific purpose. The new customizable wristband has a unique design of linking together elastic panels and rigid connectors. It's design allows users to combine links containing different images, words or phrases and connecting those links to form a band. This gives an individual the ability to not only change the look and size of the band but to display the things they are passionate about into a single wristband.
US10893721B2 Hybrid material
A process of making a family cell of homogenous inner bladders with varying elasticity includes a forming a plurality of inner bladders from a first material with a first elasticity. The inner bladders have interior surfaces during inner chambers and exterior surfaces exposed to an outside environment. The inner chambers are configured to store a fluid. A family cell is formed by fluidly connecting the inner bladders. One or more hybrid bladders are selected from the inner bladders and a second material having a second elasticity is applied to the hybrid bladders. The second elasticity is less than the first elasticity, such that the second material reduces the elastic qualities of the hybrid bladder.
US10893720B2 Footwear having sensory feedback outsole
An article of footwear may include a sole structure fixedly attached to an upper defining an internal cavity configured to receive a foot of a wearer. The sole structure may include an exposed outer member configured to contact the ground, the exposed outer member including a first aperture, and a sensory feedback member disposed at least partially within the first aperture in the outer member, the sensory feedback member including a first end and a second end. The first end of the sensory feedback member may include a projection extending through the first aperture and configured to contact the ground. In addition, the second end of the sensory feedback member may include a plurality of flexible bristles extending through a portion of the sole structure and exposed to the internal cavity.
US10893716B2 Advanced warning lighting systems and methods for motorcycle helmets
An advanced warning light system in a motorcycle has a brake light comprising a plurality of light emitting diodes (LED) wherein each LED is configured to illuminate a first color when a motorcycle brake is depressed and wherein only a subset of LEDs are configured to illuminate when the motorcycle is decelerating not in response to the brake being depressed. The system further has a controller area network (CAN) bus for transmitting messages, at least one controller configured for monitoring operations of a motorcycle, the at least one controller further configured for transmitting a message on the CAN bus when a monitored operation occurs on the motorcycle, the message comprising data indicating that the vehicle is slowing down, and a CAN bus interface configured to receive the message from the CAN bus and determine if the brake is being depressed or if the motorcycle is slowing down not in response to the brake being depressed, the CAN bus interface configured to transmit a message to illuminate all LEDs on the brake light if the brake is being depressed and configured to transmit a message to illuminate only the subset of LEDs on the brake light if the motorcycle is slowing down for a reason other than the brake being depressed. Additionally, the system has a processor configured for receiving the message from the CAN bus interface, the processor further configured for illuminating the brake light or a subset of the LEDs on the brake light based upon the message received to indicate to a driver following the motorcycle that the motorcycle is slowing down.
US10893708B1 Utility garment
A utility garment has a front garment portion adapted for positioning at a wearer's chest, a rear garment portion adapted for positioning at a wearer's back, the front portion and rear portion being removably detachable at a plurality of attachment facilities, each attachment facility including a front facility portion connected to the front garment portion and a rear facility portion connected to the rear garment portion, at least a first one of the front facility portion and the rear facility portion comprising first and second bodies, the first body defining a first cable passage and the second body defining a second cable passage, the first cable passage and the second cable passage being registered with each other and adapted to receive a single cable, and the first body and second body being spaced apart from each other to define a latch receptacle space.
US10893707B2 Portable temperature controlled aromatherapy vaporizers
Disclosed herein are aspects of portable vaporizers forming isolated vapor paths through vapor dispensers wherein a material chamber is part of a unitary furnace formed above a resistive heater and aliquots of heated air are drawn through plant-based material in the formed material chamber. A printed circuit board in signal communications with at least one temperature sensor controls the power flow to the resistance heater to select the temperature produced by heating elements in the furnace. A rechargeable battery power supply is mounted in a body to supply power the heating element.
US10893696B2 System and method for processing agricultural products
A system for processing agricultural items includes a first member having a first surface, a first axis, and a partially cylindrical space, the first surface being an inner surface of the partially cylindrical space. The system also includes a substantially arcuate second member having a second surface and a second axis, the second member being disposed at least partially in the partially cylindrical space, and the contoured second surface being an outer surface of the second member. The first surface and the second surface are substantially opposed to each other. One of the first and second surfaces substantially tapers toward another of the first and second surfaces along the first or second axes. The first and second axes are respective first and second circumferential axes.
US10893694B2 Composition remedy to prevent symptoms related to excessive alcohol consumption
An edible composition to increase the metabolism of alcohol thus prevent or lessen the symptoms caused by ingesting excessive amounts of alcohol is disclosed.
US10893690B2 Compositions for preparing sports rehydration drink
The present disclosure relates generally to sports drinks with improved ability to rehydrate individuals especially after intense physical activities. Compositions for preparing the drinks are also provided. The sports drinks can also reduce muscle soreness or fatigue, improve muscle performance, and minimize muscle cramping.
US10893688B2 High thermal transfer hollow core extrusion screw assembly
High thermal transfer, hollow core extrusion screws (50, 52, 124, 126, 190) include elongated hollow core shafts (54, 128, 130, 192) equipped with helical fighting (56, 132, 134, 194) along the lengths thereof. The fighting (132, 134, 194) may also be of hollow construction which communicates with the hollow core shafts (54, 128, 130, 192). Structure (88, 90) is provided for delivery of heat exchange media (e.g., steam) into the hollow core shafts (54, 128, 130, 192) and the hollow fighting (132, 134, 194). The fighting (56, 132, 134, 194) also includes a forward, reverse pitch section (64, 162, 216). The extrusion screws (50, 52, 124, 126, 190) are designed to be used as complemental pairs as a part of twin screw processing devices (20), and are designed to impart high levels of thermal energy into materials being processed in the devices (20), without adding additional moisture.
US10893684B2 Dietary supplement containing lyophilized dairy and linolenic acid
Described is a dietary supplement and a corresponding method to maintain the nutritional health of mammals, including humans. The composition includes a dried dairy product, typically cream, whole milk, reduced fat milk, cottage cheese, yogurt, or combinations thereof in combination with an oil comprising linolenic acid.
US10893683B2 Foaming pressurized beverage
A method of making a pressurized packaged liquid beverage including filling a container including a one-way valve with a liquid mixture including a base liquid and a gum; sealing the container; introducing a volume of gas through the one-way valve after sealing the container; and agitating the container. When the container is opened, the liquid mixture increases in volume and separates into a liquid phase and a drinkable foam phase, which may persist for an extended period of time. The base liquid includes milk, coffee, fruit juice, or mixtures thereof.
US10893682B2 Process for direct inoculation from concentrated ferments and associated device
Process for continuous inoculation of a food product, in particular a dairy product, with ferments, comprising the following steps: —solid concentrated ferments are transformed into liquid concentrated ferments, —the transformed concentrated ferments are continuously injected into a flow of liquid to be inoculated, characterized in that the liquid concentrated ferments are transformed—by thawing frozen concentrated ferments in a temperature controlled chamber or—by rehydrating freeze-dried concentrated ferments.
US10893668B2 Mosquito agitation device, system and method
A mosquito agitator system and method to disrupt the development of mosquito larvae in bodies of water are disclosed. The mosquito agitator, in one embodiment, includes a motor coupled to a rotating shaft that is coupled to a non-symmetric mass; a hull coupled to the motor; one or more solar panels coupled to the hull for capturing solar energy into electricity; a plurality of sensors; and a controller coupled to at least the motor, wherein the controller is configured to receive sensor data from the plurality of sensors; select a first mosquito agitator algorithm for execution; and execute the first mosquito agitator algorithm to control activate the motor in accordance with the first mosquito agitator algorithm, wherein the activation causes the hull to create a plurality of water ripples in the body of water to disrupt the development of mosquito larvae.
US10893662B1 Animal sensory stimulation with fur impedance detection
A collar-mounted location sensor and stimulation unit includes a body. A generally planar stimulation unit and impedance-based fur detector in combination protect the animal from harmful stimulation. At least one sensory stimulator is configured to provide at least one of auditory, kinesthetic, and visual stimulation responsive to an output of a location sensor. One or more of a voltage, current, oscillation frequency, extent of modulation, or other output characteristic of the stimulation unit output is varied responsive to the detected fur impedance to protect and benefit both the body and mind of the animal.
US10893659B2 Mobile telephone dog training tool and method
A mobile telephone adapts to use as a gundog training tool by interfacing with a dog collar using a wireless communication device, such as a WWAN text or IP interface, a WLAN interface or a radio transceiver that couples to the mobile telephone and is accessible to a training application running on the mobile telephone. The dog collar includes a GPS receiver to provide position information to the mobile telephone and a shock device to provide training stimulus to the dog. A wireless headset interfaces with the mobile telephone to provide audible indications of position to an end user, such as a dog point and tone indicators of directions to the dog. A wireless handset interfaces with the mobile telephone to accept inputs for application to the collar, such as training stimulus.
US10893655B2 Disposable cat litter box
A cat litter box is designed to be folded into a compact form for storage and shipment to a customer and unfolded by the customer for use. When it is time to replace the litter box, the cat litter box can be refolded back into a compact form for disposal. A lid 40 protects the box during storage and shipment.
US10893653B1 Maize hybrid X08N791
A novel maize variety designated X08N791 and seed, plants and plant parts thereof are produced by crossing inbred maize varieties. Methods for producing a maize plant by crossing hybrid maize variety X08N791 with another maize plant are disclosed. Methods for producing a maize plant containing in its genetic material one or more traits introgressed into X08N791 through backcrossing or genetic transformation, and to the maize seed, plant and plant part produced thereby are described. Maize variety X08N791, the seed, the plant produced from the seed, and variants, mutants, and minor modifications of maize variety X08N791 are provided. Methods for producing maize varieties derived from maize variety X08N791 and methods of using maize variety X08N791 are disclosed.
US10893651B1 Plants and seeds of hybrid corn variety CH554040
According to the invention, there is provided seed and plants of the hybrid corn variety designated CH554040. The invention thus relates to the plants, seeds and tissue cultures of the variety CH554040, and to methods for producing a corn plant produced by crossing a corn plant of variety CH554040 with itself or with another corn plant, such as a plant of another variety. The invention further relates to genetic complements of plants of variety CH554040.
US10893648B2 Cultivation floor system for cultivation of plants
A cultivation floor system with a floor includes a watertight basin with a watertight groundsheet, a water-permeable structure in the basin, and a permeable top sheet which lies substantially horizontally over the water-permeable structure and forms the top side of the floor on which plant containers are optionally placed. The basin has a water-barrier structure which protrudes above the floor and delimits the compartment which is present on the floor. The water-barrier structure includes a horizontal beam with a top side, a water-barrier profile with a bottom side, and fastening means which fasten the water-barrier profile to the horizontal beam. The top side of the beam is substantially level with the top side of the floor formed by the permeable top sheet. The bottom side of the water-barrier profile is pulled onto the top side of the horizontal beam while clamping the watertight groundsheet and the permeable top sheet.
US10893645B2 Mobile bale and feed processor and method
A bale processor has a towed body that includes one or two hay bale shredders in the form of a flail drum. The bale processor is self-loading such that bales may be loaded in the processing tubs by a set of rear mounted arms and various conveyor chains. The processor also includes a grain tank, a grain metering system, and a grain cracker, all mounted in series. The grain cracker may have a choice of outputs, including back to the grain tank. The cracked grain is fed into the tub to be mixed with other feed materials, such as shredded straw, and is then discharged to the opposite side of the unit. There may be a feed chopper mounted downstream of the tub, such that the feed chopper receives both the grain material and the shredded hay feed. The feed chopper and the grain cracker operate independently, and may have different setting of size, speed, and weight or volume per minute or per unit of distance travelled. The output may have a curtain assembly to facilitate deposit in windrows.
US10893642B2 Agricultural vehicle with bidirectional force exerting electric three-point hitch assemblies
An electric tractor including one or more all-electric bidirectional force exerting three-point hitch assemblies for lifting and lowering farm tool implements in level relationship to the ground regardless of the elevation of lift applied to the implement. The front, middle and rear three-point hitch assemblies are each operated using linear actuators. The hitches may be coupled with battery boxes to provide power and to counterbalance attached farm implements. Each of the described three-point hitch assemblies (including embodiments for front, middle and rear positions) may be operated through manipulation of electric controls. Electronic components include controller, displays, panels, wiring harnesses, linear actuators, joy sticks, lighting, switches, gauges, electric battery management system for managing one or more power sources, and processing modules and memory for controlling hitch movement and implements. The three-point hitch assemblies enable work in the front, middle and rear areas of the tractor.
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