最新美国发明专利第2019-04-09期 - 专利汇|PatentHub专利检索|专利查询网|发明专利查询分析

Document	Document Title
US10253402B2	Sheet made of aluminum alloy for the structure of a motor vehicle body The invention relates to the use of a sheet made of an aluminium alloy for manufacturing a stamped bodywork or structural part of a motor vehicle body, also referred to as a “body in white”, wherein said sheet has a yield strength Rp0.2 no lower than 60 MPa and a tensile elongation Ag0 no lower than 34%. The invention also relates to a method for making such a stamped bodywork or structural part for a motor vehicle body, made from said sheet and selected in the group including inner panels or linings for car doors, a passenger compartment floor, a boot floor, a spare wheel housing, or even a passenger compartment side.
US10253401B2	Method for relieving residual stress in cast-in-place liners of HPDC engine blocks A method for relieving residual stress in cast-in-place liners of high pressure die cast (HPDC) engine blocks to prevent cracking in the liners during the machining process. The method includes locally heating up the liners and the surrounding engine block material through rapid induction heating and then cooling down the liners and surrounding engine block material with still ambient air to a predetermined temperature after the residual stress has been reduced to a desired threshold.
US10253396B2	Modified articles, coated articles, and modified alloys A modified alloy is disclosed including a base alloy composition and an additive gamma prime antioxidant. The base alloy composition includes a concentration of a gamma prime antioxidant less than an effective concentration of the gamma prime antioxidant. The additive gamma prime antioxidant is intermixed with the base alloy composition to form the modified alloy, preferentially segregating to a gamma prime phase of the modified alloy and increasing the concentration of the gamma prime antioxidant to be at least the effective concentration of the gamma prime antioxidant. The effective concentration imparts reduced oxidation susceptibility of the gamma prime phase. An article is disclosed including the modified alloy. A coated article is disclosed including a coating disposed on a surface of an article having the base alloy composition. The coated article includes a reduced stress accelerated gamma prime oxidation static crack growth susceptibility in comparison with the base alloy composition.
US10253392B2	Apparatus for treating magnetic wire and method for treating the same Apparatus for heat treating magnetic wire includes a wire supply unit, a wire property measuring unit, a wire tensile force measuring unit, a heat treatment unit, and a wire winding unit. The wire supply unit includes a supply bobbin, a supply rotary part, a wire reel, and a tension roller. The wire property measuring unit includes a size measuring device, an after measurement capstan, and a wire reel and measures a size of the wire prior to the heat treatment. The wire tensile force measuring unit includes a tensile force measuring device, a tension roller, and a wire reel. The wire heat treatment unit includes a heat treatment furnace, a temperature measuring device, an after heat treatment capstan, and a wire reel. The wire winding unit includes a winding bobbin, a winding rotary part that rotates the winding bobbin, a tension roller, and a wire reel.
US10253391B2	Components made of a steel alloy and method for producing high-strength components The invention concerns a component made of a steel alloy comprising iron and as alloying element copper, in particular consisting of (in wt % in relation to the total alloy, wherein the sum of all constituents equals 100 wt %) iron≥96, carbon 0.04 to 0.12, copper 0.5 to 2.0, manganese+silicon+chromium+nickel 0.5 to 2.5, titanium 0 to 0.1, boron 0 to 0.005, and typical unavoidable impurities. In the production of semi-finished goods and of components, a combination of cold working and annealing treatment below the recrystallization temperature is used in order to thus obtain advantageous properties with regard to strength and ductility.
US10253390B2	Method of manufacturing a cold-rolled steel plate A method of making a cold-rolled steel plate has a chemical composition containing, on the basis of percent by mass, C from 0.03 to 0.12%, Si from 0 to 1.0%, Mn from 0.2 to 0.8%, P at 0.03% or less, S at 0.03% or less, and Al at 0.05% or less. The chemical composition further contains any one of Nb from 0.03 to 0.4% and V from 0.03 to 0.3%. These elements satisfy 5C %−Si %+Mn %−1.5Al %<1 within the aforementioned range of the corresponding content. A residue is formed of Fe and unavoidable impurities. An average diameter of particles of carbides containing any one of Nb, V and Ti as precipitates is from 20 to 100 nm. In this way, the chemical composition is regulated and the precipitates are dispersed finely and uniformly, thereby enhancing heat spot resistance and antiwear performance.
US10253380B2	Mutant strains of the genus Clostridium beijerinckii The present invention relates to mutant bacteria of the genus Clostridium beijerinckii, CNCM I-4985, CNCM I-4986, CNCM I-4987 and CNCM I-4988, deposited at the Institut Pasteur (CNCM, 25 rue du Docteur Roux, F-75724 PARIS Cedex 15, France) on 27 May 2015, and CNCM I-5027, CNCM I-5028 and CNCM I-5029 deposited at the Institut Pasteur (CNCM, 25 rue du Docteur Roux, F-75724 PARIS Cedex 15, France) on 26 Nov. 2015, which are useful in the fermentation of sugars for the production of isopropanol and butanol.
US10253379B1	Disease resistance alleles in soybean Methods for conveying Phytophthora sojae resistance into non-resistant soybean germplasm are provided. In some embodiments, the methods include introgressing Phytophthora sojae resistance into a non-resistant soybean using one or more nucleic acid markers for marker-assisted breeding among soybean lines to be used in a soybean breeding program, wherein the markers are linked to and/or associated with Phytophthora sojae resistance. Also provided are single nucleotide polymorphisms (SNPs) associated with resistance to pathogens; soybean plants, seeds, and tissue cultures produced by any of the disclosed methods; seed produced by the disclosed soybean plants; and compositions including amplification primer pairs capable of initiating DNA polymerization by a DNA polymerase on soybean nucleic acid templates to generate soybean marker amplicons to be used in selecting or identifying Phytophthora sojae resistant soybean lines.
US10253377B2	Systems and methods to assess microbiomes and treatments thereof Systems and methods to assess the health of various microbiomes and to identity species therein are disclosed. Described assessments and identifications can inform treatment decisions if a microbiome is determined to have a less than optimal balance of bacterial species within it; the presence of one or more negative species; and/or the absence of one or more positive species.
US10253376B2	DNA-based detection and identification of eight mastitis pathogens LAMP primer sets for detecting eight mastitis pathogens are disclosed. Methods and kits of using the primer sets to simultaneously detect at least two of the eight mastitis pathogens are also described.
US10253375B1	Massively parallel single cell analysis The disclosure provides for methods, compositions, and kits for multiplex nucleic acid analysis of single cells. The methods, compositions and systems may be used for massively parallel single cell sequencing. The methods, compositions and systems may be used to analyze thousands of cells concurrently. The thousands of cells may comprise a mixed population of cells (e.g., cells of different types or subtypes, different sizes).
US10253374B2	Non-invasive assays for embryo quality Differentially expressed miRNA or small mRNA in the culture media of embryos were found to correlate to and affect embryo developmental fate. Accordingly the present invention provides a method for selecting a bovine embryo for implantation into a female bovine animal for further development based on the levels of specific miRNA or small mRNA. Also provided are methods of improving bovine embryo development fate by reducing in the culture medium the level of selected miRNAs.
US10253372B2	Method for detecting an increased risk or incidence of colorectal cancer The present invention relates to the methods and products for detection of colorectal cancer. Additionally, the present invention relates to methods and products for determining the probability, risk or incidence of colorectal cancer and of colorectal cancer metastasis. The products and methods of the present invention include detecting the level of expression of COL10A1 or MMP11, in combination, from samples, including tissue samples, from humans who currently have been diagnosed with cancer or who were previously diagnosed with cancer and those who are thought to have cancer and are undergoing diagnosis.
US10253369B2	Predicting likelihood of response to combination therapy Provided are methods of determining whether a subject having ER+ breast cancer is expected to benefit from treatment with combination endocrine therapy and mTOR inhibitor therapy. Also provided are methods of treating a subject having ER+ breast cancer.
US10253363B2	Materials and methods to analyze RNA isoforms in transcriptomes The present invention includes, but is not limited to, methods, assays, and compositions for preparing libraries of nucleic acid molecules from biological samples, and for detecting and measuring the abundances of nucleic acid molecules, including RNA and DNA. The methods, assays, and compositions of the present invention provide in whole or in part for the detecting and measuring the abundances of nucleic acid molecules, and particularly but not limited to those nucleic acids that have structures that cannot be determined reliably by routine alignment to a reference sequence or concatenation of smaller sequences by matching homologous ends.
US10253362B2	DNA transport control device and method for producing same, as well as DNA sequencing device The purpose of the present invention is to provide a DNA transport control device having excellent reliability and durability, and a DNA sequencing device that uses the DNA transport control device. The present invention provides a DNA transport control device having a nanopore which allows for the passage of only the DNA strand of a single molecule, and a DNA sequencing device that uses the DNA transport control device. The DNA transport control device is characterized by the following: including a base material having openings and a thin film a block copolymer formed on the base material; the thin film including microdomains that are formed as a result of self-assembly of the block copolymer and that penetrate the thin film, and a matrix surrounding the microdomains; and the nanopore being formed from one opening in the base material and a single microdomain.
US10253361B2	Sample block apparatus and method for maintaining a microcard on a sample block A thermal cycling device for thermally cycling samples of biological material contained in a microcard having a top and bottom surface. The thermal cycling device can include a sample block having an upper surface configured for engaging the bottom surface of a microcard, a vacuum device, and a temperature control system operatively connected with the sample block. The upper surface of the sample block may include a plurality of channels, the channels defining spaces between the sample block and the bottom surface of a microcard that may be positioned thereon. The vacuum device may be in fluid communication with the sample block for drawing gas out of the spaces defined by the channels in the sample block. The vacuum device may be configured for substantially maintaining a vacuum between the sample block and microcard so that a retention force is imparted on the microcard to urge the microcard toward the sample block. Methods of maintaining a microcard on a sample block of a thermal cycling device are also provided.
US10253351B2	Preservation of cell-free nucleic acids A method for preserving and processing cell-free nucleic acids located within a blood sample is disclosed, wherein a blood sample containing cell-free nucleic acids is treated to reduce both blood cell lysis and nuclease activity within the blood sample. The treatment of the sample aids in increasing the amount of cell-free nucleic acids that can be identified and tested while maintaining the structure and integrity of the nucleic acids.
US10253348B2	Microstructure for capturing and releasing microorganism Provided is a method for capture and release of microorganisms using microstructures. The method includes providing microstructures coated with a protein for attachment/detachment of microorganisms, mixing the microstructures with a solution containing substances assisting in attachment of microorganisms in a solution containing microorganisms to prepare a mixed solution, stirring the mixed solution to attach the microorganisms to the microstructures, separating the microorganism-attached microstructures from the mixed solution; and exposing the microstructures to an environment where the substances assisting in attachment of the microorganisms are present at a low concentration to detach the microorganisms from the microstructures.
US10253345B2	Cell lines There is provided inter alia a process for stabilizing a eukaryotic cell line which expresses PylRS and tRNAPyl and which is suitable for incorporation of a gene encoding a target protein containing one or more non-natural amino acids encoded by a nonsense codon which comprises culturing said cell line under conditions in which the adverse effect of tRNAPyl expression on cell viability and/or cell growth is reduced or eliminated.
US10253342B2	Polypeptides having catalase activity and polynucleotides encoding same The present invention relates to isolated polypeptides having catalase activity and polynucleotides encoding the polypeptides. The invention also relates to nucleic acid constructs, vectors, and host cells comprising the polynucleotides as well as methods of producing and using the polypeptides.
US10253338B2	Conversion of biomass to useful intermediates An aspect of the present disclosure is a microbial cell that includes a genetic modification resulting in the expression of a deficient form of an endogenous dioxygenase, and a gene encoding an exogenous dioxygenase and a promoter sequence, where the endogenous dioxygenase includes PcaH and PcaG, the exogenous dioxygenase includes LigA and LigB, the microbial cell is capable of growth utilizing at least one of a cellulose decomposition molecule or a lignin decomposition molecule, and the microbial cell is capable of producing 2-hydroxy-2H-pyran-4,6-dicarboxylic acid.
US10253312B2	CRISPR/CAS-related methods and compositions for treating Leber's Congenital Amaurosis 10 (LCA10) CRISPR/CAS-related compositions and methods for treatment of Leber's Congenital Amaurosis 10 (LCA10) are disclosed.
US10253309B2	Apparatus for separating fine particles using magnetophoresis, and method for separating fine particles using same The present invention relates to an apparatus for separating fine particles using magnetophoresis, and to a method for separating fine particles using same, and particularly, to an apparatus for separating fine particles using magnetophoresis, which includes a fine, patterned magnetic structure capable of quickly and efficiently separating even particles that are weakly magnetized and coupled to fine particles, and to a method for separating fine particles using same.
US10253306B2	Modified beta-lactamases and methods and uses related thereto The present invention relates to pharmaceuticals and modified beta-lactamases. Specifically, the invention relates to novel recombinant beta-lactamases and pharmaceutical compositions comprising the beta-lactamases. Also, the present invention relates to methods for modifying a beta-lactamase, producing the beta-lactamase and treating or preventing beta-lactam antibiotic induced adverse effects. Furthermore, the present invention relates to the beta-lactamase for use as a medicament and to the use of the beta-lactamase in the manufacture of a medicament for treating or preventing beta-lactam antibiotics induced adverse effects.Still further, the invention relates to a polynucleotide and a host cell comprising the polynucleotide.
US10253302B2	Method for producing ordered protein lattice A method for producing an ordered protein lattice, the method comprising: (a) providing a first component comprising a subunit of a homooligomeric protein assembly fused to a first subunit of a heterooligomeric protein assembly, and a second component comprising a second subunit of the heterooligomeric protein assembly, wherein the homooligomeric protein assembly and the heterooligomeric protein assembly are each symmetrical in two or three dimensions and share a rotational symmetry axis of the same order; (b) mixing said first monomer and said second monomer to produce a mixture; and (c1) (i) heating the mixture to a temperature about 2° C. to about 10° C. below the visible dissociation temperature; (ii) cooling the mixture by about 10° C. to about 20° C.; and (iii) repeating steps (i) and (ii) at least 10 times; or (c2) (i) heating the mixture to a temperature about 2° C. to about 30° C. or more below the visible dissociation temperature; and (ii) holding the mixture at a temperature about 2° C. to about 30° C. or more below the melt temperature, thereby producing an ordered protein lattice.
US10253301B2	Removal of contaminating viruses from AAV preparations The present invention relates to a separation of viruses of an essentially spherical shape from viruses with a rod-like shape that are comprised in a sample, wherein the sample comprising the viruses is subjected to filtration.
US10253300B2	Adapted rhinovirus C A mutated rhinovirus C, methods of creating and methods of propagating thereof, wherein the mutated rhinovirus shows enhanced virus yields after infection and induced visible cytopathic effect.
US10253298B2	Methods for generating stem cell-derived beta cells and methods of use thereof Disclosed herein are methods for generating SC-β cells, and isolated populations of SC-β cells for use in various applications, such as cell therapy.
US10253296B2	Synthetic membrane-receiver complexes Compositions comprising synthetic membrane-receiver complexes, methods of generating synthetic membrane-receiver complexes, and methods of treating or preventing diseases, disorders or conditions therewith.
US10253293B2	Chemical reprogramming of human glial cells into neurons with small molecule cocktail Provided are compositions, articles and methods that relate to promoting neurogenesis or neuroregeneration in mammalian nervous system. Embodiments relate to use of groups of compounds that contain Crizotinib (Cri), Flurbiprofen, Lithium Chloride (Li), Vitamin C (VC), Ceritinib (Cer) or Pirfenidone (PFD). In certain implementations glial cells are converted into functional neurons.
US10253290B2	Bioreactor arrangement, shaking device and method for irradiating a medium in a bioreactor A bioreactor arrangement has a bioreactor and an illuminating body for illuminating a medium in a reactor interior. The illuminating body has at least one emission surface via which light, reflected by at least one end surface into the reactor interior, is emitted. The bioreactor is formed as a container having a transparent wall. The illuminating body is outside the reactor interior, next to at least one subregion of the transparent wall. The illuminating body forms a support surface for the bioreactor with its emission surface. A shaking device has a reactor holder that can be in oscillated, for a bioreactor with a transparent wall. The reactor holder has a two-dimensional illuminating body, the emission surface of which forms a support surface for the bioreactor, via which light can be reflected into the reactor interior of the bioreactor.
US10253288B2	Receptacle for accepting nutrient media Disclosed is a receptacle for accepting nutrient media, especially for bacterial cultures. Said receptacle comprises a dish and a lid that covers the dish. The dish and the lid each have a circular bottom (dish bottom and lid bottom) and an annular wall (dish wall and lid wall) that projects from the bottom. One of the walls, preferably the lid wall, has an at least slightly larger internal diameter than the external diameter of the other wall, preferably the dish wall, such that one wall can be slid onto the other wall to close the dish. In order to be able to safely handle the receptacle, engaging means which prevent the dish and the lid from being accidentally released when the same are mutually engaged, are associated with the dish and the lid.
US10253285B2	Method for simultaneously reducing urethane and its precursors levels during Chinese liquor production process The present invention a method for simultaneously reducing urethane and its precursors levels during Chinese liquor production process, which relates to the field of fermented food production. The present invention is carried out through inoculating Bacillus amyloliquefaciens JP21 or combines with urease into the grains for fermentation. The content of EC and urea in the fermented grains after 5-day fermentation could reduce 30.16% and 50.05% respectively, With an addition of the B. amyloliquefaciens during grains fermentation, EC and urea levels are successfully controlled, and at the same time aroma and tastes of Chinese liquor hasn't been affected.
US10253280B2	Additive for reducing spotting in automatic dishwashing systems A phosphorus-free automatic dishwashing detergent composition comprising: (a) 0.5 to 10 wt % of a polymer comprising polymerized units of: (i) 65 to 75 wt % (meth)acrylic acid, (ii) 15 to 25 wt % of a monoethylenically unsaturated dicarboxylic acid and (iii) 7 to 13 wt % 2-acrylamido-2-methylpropanesulfonic acid (AMPS); and having Mw from 5,000 to 100,000; (b) 15 to 50 wt % carbonate, (c) 0 to 50 wt % citrate and (d) 10 to 40 wt % of a bleaching agent.
US10253279B2	Development of extensional viscosity for reduced atomization for diluted concentrate sprayer applications A non-Newtonian concentrate composition includes a sensitizer or irritant, a surfactant, an anti-mist component and optionally a stability component. Example sensitizers and irritants include, but are not limited to, acids, quaternary compounds, and amines, and example anti-mist components include, but are not limited to, polyethylene oxide and polyacrylamide.
US10253274B2	Compounds and methods for inhibiting corrosion in hydrocarbon processing units Treatment compositions for neutralizing acidic species and reducing hydrochloride and amine salts in a fluid hydrocarbon stream are disclosed. The treatment compositions may comprise at least one amine with a salt precipitation potential index of equal to or less than about 1.0. Methods for neutralizing acidic species and reducing deposits of hydrochloride and amine salts in a hydrocarbon refining process are also disclosed. The methods may comprise providing a fluid hydrocarbon stream and adding a treatment composition to the fluid hydrocarbon stream. The treatment compositions used may have a salt precipitation potential index of equal to or less than about 1.0 and comprise either water-soluble or oil-soluble amines.
US10253272B2	Process for hydrotreating a residue stream The subject process enhances catalytic activity for demetallization and desulfurization of a residue feed stream by injecting water into the feed and hydrotreating in two stages with interstage separation. Water injection improves the demetallation activity of the HDM catalyst and separating vapor comprising hydrogen sulfide from the demetallized effluent improves the activity of the HDS catalyst. We have discovered that the water injection and hydrogen sulfide removal together provide a profound synergetic effect.
US10253271B2	Systems and methods for refining corrosive crudes Systems and methods for refining conventional crude and heavy, corrosive, contaminant-laden carbonaceous crude (Opportunity Crude) in partially or totally separated streams or trains.
US10253269B2	Method to migrate fouling of a vacuum wash bed Fluid medium such as light cycle oil, water, FCC slurry and decanted oil, improve this method for vacuum distillation of a petroleum product. The method may be used in the petroleum refining industry for fractionating of petroleum base stock in a vacuum column. The fluid medium prevents the formation of thermoset polymers and the resultant fouling of the wash beds in the vacuum column.
US10253266B2	Synthetic fuels and chemicals production with in-situ CO2 capture Novel redox based systems for fuel and chemical production with in-situ CO2 capture are provided. A redox system using one or more chemical intermediates is utilized in conjunction with liquid fuel generation via indirect Fischer-Tropsch synthesis, direct hydro genation, or pyrolysis. The redox system is used to generate a hydrogen rich stream and/or CO2 and/or heat for liquid fuel and chemical production. A portion of the byproduct fuels and/or steam from liquid fuel and chemical synthesis is used as part of the feedstock for the redox system.
US10253259B2	Polymerizable compound having conjugated bonds, liquid crystal composition and liquid crystal display device SubjectIt is to provide a polymerizable compound having a high polymerization reactivity, a high conversion yield and a high solubility in a liquid crystal composition, a polymerizable composition including this compound, a liquid crystal composite prepared from this polymerizable composition and a liquid crystal display device containing this composite.Means for solving the SubjectA compound represented by formula (1), the liquid crystal composition and the liquid crystal display device. In the formula, for example, ring A1, ring A2 and ring A4 are phenylene or cyclohexylene; Sp1 and Sp2 are a single bond or alkylene having 1 to 6 carbons; Z1 and Z2 are —CH═CH— or —C≡C—; a is 1, b is 0; and P1 and P2 are a polymerizable group.
US10253258B2	Nematic liquid crystal composition The present invention provides a liquid crystal composition including at least one compound represented by General Formula (1), at least one compound represented by General Formula (2), and at least one compound represented by General Formula (LC1). The liquid crystal composition of the present invention has high refractive index anisotropy (Δn) and sufficiently low viscosity (η), achieves a wide nematic phase temperature range by suppressing a decrease in nematic phase-isotropic liquid phase transition temperature (Tni), and exhibits high compatibility. By using the liquid crystal composition of the present invention in a liquid crystal display element, a liquid crystal display element having a high response speed and high practical reliability can be obtained.
US10253254B2	Substituted benzo[f]imidazo[1,2-a]quinoxalines The disclosure comprises novel Coelenterazine compounds and methods of use, including a simple delivery device for the photoprotein to create effects by their luminous reaction upon contact with surfaces that contain calcium. Calcium is ubiquitous in and on most surfaces and in the environment; it is this unique property of calcium that makes this a novel use of the photoproteins for entertainment. A base coelenterazine structure is depicted below.
US10253225B2	APCHA as a building block in curing agent formulations for structural adhesives The invention relates to structural adhesive compositions and more particularly to two-component (2K) structural adhesive compositions. The two components chemically react to bond structural surfaces. N-(3-Aminopropyl)cyclohexylamine (APCHA) has been found to be an improved curing agent for use with epoxy resins in 2K adhesive compositions. APHCA exhibits favorable features including viscosity, pot life and reactivity, and adhesive and thermal performance after curing with epoxy resin. These features and its unique chemistry allow the use of APCHA in curing agent formulations for structural adhesives, in particular wind turbine blade adhesives. APCHA solves issues with viscosity build-up, working time, through-cure, compatibility and adhesive performance that cannot be addressed with the commonly used amine formulations.
US10253224B2	Adhesive composition for touch panels, adhesive film, and touch panel Provided is an adhesive composition for touch panels, including: an acrylic resin; a first curing agent having one to three functional groups; and a second curing agent having four to six functional groups. Provided is an adhesive film including an adhesive layer, which is a cured product of the adhesive composition for touch panels. Provided is a touch panel including: a conductive plastic film which has a conductive layer formed on one side thereof; and an adhesive layer which is attached to the conductive layer and includes a cured product of the adhesive composition for touch panels.
US10253221B2	Adhesive To provide an adhesive excellent in heat resistance and adhesive property. An adhesive comprising a fluorinated polymer having a weight average molecular weight (Mw) of from 6×103 to 3×104 and having iodine atoms at both terminals, and a radical generator. The fluorinated polymer has structural units derived from at least one monomer selected from the group consisting of tetrafluoroethylene, vinylidene fluoride, hexafluoropropylene and a perfluoro(alkyl vinyl ether).
US10253218B2	Adhesive tape An adhesive tape includes: a sheet-like base; an undercoat layer that is laminated on the base and contains an acid modified compound; and an adhesive agent layer that is laminated on the undercoat layer and contains butyl rubber, an alicyclic saturated hydrocarbon resin and a multifunctional epoxy-based compound.
US10253209B2	Paint replacement film with polymer layer containing polyurethane A paint replacement film comprising a polymer layer comprising a polyurethane produced from a formulation comprising at least one blocked isocyanate. The paint replacement film comprises a liner layer and the formulation comprises at least two polyols in OH weight equivalent ratio in the range 4.5:1 to 1:4.5. The formulation may comprise a colorant and the polyurethane may have a glass transition temperature (Tg) below 42° C. Also disclosed is a method of producing a paint replacement film, by providing a backing layer, providing the liquid formulation, cast-coating the backing layer with the liquid formulation, and gelling the liquid formulation, thereby forming a polymer layer comprising polyurethane. The paint replacement films are useful for replacing paint on surfaces especially in automotive applications.
US10253205B2	Aqueous composition for forming a hardcoat layer and hardcoat layer A high-refractive-index hardcoat layer of a sufficiently reduced haze value can be obtained from an aqueous composition containing Si, Al and at least one of Ti and Zr, in which the ratio of the number of atoms of Ti and Zr with respect to the number of atoms of Si is 2.5 to 18, the ratio of the number of atoms of Al with respect to the number of atoms of Si is 0.08 to 0.22, and the aqueous composition has a haze value of 0.5% or less.
US10253199B2	Inkjet ink An inkjet ink includes a polyamide resin; at least one tackifier that is selected from the group consisting of a terpene phenol resin and a rosin ester, and that has a hydroxyl value that ranges from 10 to 45 mgKOH/g; a solvent dye; and an alcohol having 1 to 3 carbon atoms. The inkjet ink has quick-drying properties, is capable of satisfactorily improving printing fixability with respect to a non-absorptive printing object made of polyolefin or the like, is excellent in storage stability so that precipitation etc., do not easily occur for a long time, and is excellent in intermittent printability so that the nozzle of an inkjet printer is not easily clogged during a decapping time.
US10253195B2	Coreactive materials and methods for three-dimensional printing Methods of printing a three-dimensional object using co-reactive components are disclosed. Thermosetting compositions for three-dimensional printing are also disclosed.
US10253193B2	Photoactivatable crosslinker Described herein is a degradable linking agent of formula Photo1-LG-Photo2, wherein Photo1 and Photo2 independently represent at least one photoreactive group and LG represents a linking group comprising one or more silicon atoms or one or more phosphorous atoms. The degradable linking agent includes a covalent linkage between at least one photoreactive group and the linking group, wherein the covalent linkage between at least one photoreactive group and the linking group is interrupted by at least one heteroatom. A method for coating a support surface with the degradable linking agent, coated support surfaces and medical devices are also described.
US10253187B2	Nano-structure of block copolymer and method of manufacturing the same A nano-structured block copolymer that includes a self-assembled block copolymer disposed on a substrate, wherein the block copolymer includes a plurality of block structural units, and at least two block structural units have a solubility parameter difference of greater than or equal to about 5 megaPascal1/2.
US10253178B2	Flowability improver for polycarbonate and polyarylate, polycarbonate resin composition, polyarylate resin composition, and molded article thereof A method of improving flowability of polycarbonate or polyarylate includes mixing the polycarbonate or the polyarylate with a flowability improver including a polyester. The polyester is a polycondensate of monomers including a bisphenol component (B) and a dicarboxylic acid component (C) at a molar ratio satisfying (B):(C)=45:55-55:45. The polyester includes a portion derived from the bisphenol component (B) and the dicarboxylic acid component (C) in an amount of 50 mol % or more.
US10253175B2	Acrylic resin film having excellent resistance to whitening on bending and excellent cracking resistance Disclosed herein is an acrylic resin film that is less likely to whiten on bending when laminated on a plastic molded body or the like, has well-balanced physical properties such as high surface hardness, excellent transparency, and excellent cracking resistance, and is therefore suitable for use in decorative molding. The acrylic resin film is obtained by forming, into a film, a methacrylic resin composition (D) containing a specific methacrylate-based resin (A), a rubber-containing four-stage graft copolymer (B) containing rubber particles having an average particle size of 0.2 to 0.4 μm, and a rubber-containing two-layer graft copolymer (C) containing rubber particles having an average particle size of 0.02 to 0.15 μm.
US10253174B2	Vulcanized polymer blends A heterogeneous vulcanized polymer blend comprising a continuous phase comprising a thermoplastic polypropylene having a crystallinity of at least 30% and a dispersed phase comprising particles of an elastomeric copolymer dispersed in the continuous phase and having an average particle size of less than 5 micron. The elastomeric copolymer has a crystallinity of less than 20% and is at least partially cross-linked such that no more than about 80 wt % of the elastomeric copolymer is extractable in cyclohexane at 23° C.
US10253172B2	Air bag cover and thermoplastic elastomer composition therefor There is provided a thermoplastic elastomer composition for an air bag cover obtained by dynamically heat-treating, in the presence of a cross-linking agent, and the following components (A1), (B) and (C), wherein component (A1): a propylene-based resin, component (B): an ethylene-α-olefin-nonconjugated diene copolymer rubber, and component (C): a mineral oil-based softener, which is excellent in appearance and mechanical strength.
US10253169B2	Polyamide compositions Flame resistant compositions based on nylon-6 (PA 6) or nylon-6,6 (PA 66) may include melamine cyanurate, titanium dioxide, glass fibers, and non-fibrous and non-foamed ground glass having a specific particle size distribution, geometry and optionally sizing. Methods for producing the composition are also provided, as well as use of the compositions for production of products for the electrical industry, preferably electrical components such as residual current circuit breakers and other circuit breakers.
US10253168B2	Additive composition for amine hardeners, use of said additive composition, and amine hardener composition containing said additive composition The invention relates to an additive composition, which comprises a thickener and a thixotropic agent and is characterized in that the thickener is cellulose or a derivative thereof and that the thixotropic agent is a pyrogenically produced silicic acid, the surface of which is modified with groups of general formula (I) —SiRaR1bOR2c (I), in which a can equal 1, 2, or 3, b can equal 0, 1, or 2, and c can equal 0, 1, or 2, wherein a+b+c=3, and R can be a monovalent, optionally monounsaturated or polyunsaturated, optionally branched hydrocarbon group having 1 to 24 carbon atoms, R1 can be a likewise monovalent, optionally monounsaturated or polyunsaturated, optionally branched hydrocarbon group having 1 to 20 carbon atoms, and R2 can be a hydrogen atom, a monovalent, optionally monounsaturated or polyunsaturated, optionally branched hydrocarbon group having 1 to 20 carbon atoms, or a bond to another Si atom, with the stipulation that at least one of the groups R or R1 is a hydrocarbon group having more than 3 carbon atoms.
US10253162B2	Polyurethane polymers and compositions made using discrete carbon nanotube molecular rebar In various embodiments a urethane/molecular rebar formulation comprising a specific composition is disclosed. The composition comprises a urethane polymer or prepolymer/discrete carbon nanotube formulation. Utility of the urethane/molecular rebar composition includes improved foams and adhesives.
US10253161B2	Thermoformed container and production method thereof Provided is a thermoformed container having a superior appearance as a result of inhibition of coloring and generation of defects during the melt molding, having sufficient strength, and further having a self-purge feature in a production process. The thermoformed container includes an EVOH layer (A) containing an ethylene-vinyl alcohol copolymer (I) as a principal component, wherein the EVOH layer (A) contains a carbonyl compound (II), the carbonyl compound (II) is an unsaturated aldehyde (II-1), a saturated aldehyde (II-2), a saturated ketone (II-3) or a combination thereof, and the content of the carbonyl compound (II) in the EVOH layer (A) is 0.01 ppm or greater and 100 ppm or less. The carbonyl compound (II) is preferably an unsaturated aldehyde (II-1), and the unsaturated aldehyde (II-1) is preferably an unsaturated aliphatic aldehyde.
US10253159B2	Hydrophobic aerogel materials The present disclosure provides an aerogel composition which is durable and easy to handle, which has favorable performance in aqueous environments, and which also has favorable combustion and self-heating properties. Also provided is a method of preparing an aerogel composition which is durable and easy to handle, which has favorable performance in aqueous environments, and which has favorable combustion and self-heating properties. Further provided is a method of improving the hydrophobicity, the liquid water uptake, the heat of combustion, or the onset of thermal decomposition temperature of an aerogel composition.
US10253157B2	Shape memory thermal interface materials Disclosed is a shape memory polymer (SMP) thermal interface material. The shape memory polymer may include a SMP matrix. The SMP matrix may include a liquid crystal elastomer. The SMP material may also include a thermally conductive filler embedded within the SMP matrix. The thermally conductive filler may include one or more substantially aligned subcomponents.
US10253156B2	Process for producing dispersion of fine inorganic particles, curable composition containing said dispersion, and cured object obtained therefrom Provided are a cured material having a high refractive index for an optical member obtained by preparing a stable dispersion with a small amount of dispersant, and a process for producing dispersion of fine inorganic particles which is capable of drastically shortening the dispersion process time without causing overdispersion under the conditions of high solid concentration and without using media having a small particle size, which are very expensive and for which available dispersing machines are limited. Provided are a process for producing dispersion of fine inorganic particles using a media type wet dispersing machine, which includes supplying the following (A) to (D) to the wet dispersing machine, provided that (D) is supplied last to the wet dispersing machine: (A) Zirconium oxide nanoparticle, (B) Silane coupling agent, (C) Dispersion medium, and (D) Dispersant; a curable composition containing a dispersion obtained by the producing process; and a cured material obtained therefrom.
US10253154B2	In situ exfoliation method to fabricate a graphene-reinforced polymer matrix composite A method for forming a graphene-reinforced-polymer matrix composite by distributing graphite microparticles into a molten thermoplastic polymer phase comprising one or more molten thermoplastic polymers; and applying a succession of shear strain events to the molten polymer phase so that the molten polymer phase exfoliates the graphene successively with each event, until tearing of exfoliated multilayer graphene sheets occurs arid produces reactive edges on the multilayer sheets that react with and cross-link the one or more thermoplastic polymers; where the one or more thermoplastic polymers are selected from thermoplastic polymers subject to UV degradation.
US10253152B2	Process for preparing a porous layer The present invention relates to a process for preparing a porous layer of biocompatible polymer, having a uniform density and porosity, comprising the following steps: a) a quantity Qp of solution of the said polymer, having a viscosity Vp, is poured into a mold in order to form a first sublayer, the surface of the first sublayer being left to the open air; b) a quantity Qs of solvent, having a viscosity Vs, lower than Vp, is spread uniformly over the surface of the first sublayer so as to form a second sublayer; c) the first and second sublayers are subjected to a step of lyophilization, in which the said polymer is a polysaccharide chosen from hyaluronic acid, alginic acid and chitosan, salts thereof and mixtures thereof.
US10253149B2	Article with controlled cushioning Pellets, beads, particles, or other pieces of a thermoplastic elastomer having a maximum size in at least one dimension of 10 mm or less (collectively, “pellets”) are infused with a supercritical fluid in a pressurized container, then rapidly depressurized and heated either by immersion in a heated fluid or with infrared or microwave radiation to foam the pellets The pellets are prepared with at least two different densities. Pellets with different densities, thermoplastic elastomer compositions, or foam response rates are placed in different areas of a mold. The mold is filled with pellets, then the pellets are molded into a part. The part has areas of different density as a result of the placement of pellets of different density.
US10253145B2	Method for producing a polylactic acid-based film or sheet A method of producing a polylactic acid based film or sheet with improved heat resistance and comprised of a resin composition containing a polylactic acid according to a melt film forming method, wherein the resin composition comprises polylactic acid (A), an acidic functional group-denatured olefin based polymer (B) containing an acidic functional group, and having an acid number of 10-70 mg KOH/g and a weight average molecular weight of 10,000-80,000, and a tetrafluoroethylene based polymer (C), which method comprises performing melt film formation at a temperature of the resin composition between the crystallization temperature (Tc) in a decreasing temperature process of the resin composition +15° C. and the melting temperature (Tm) in a raising temperature process −5° C., or solidifying the resin composition melt-formed in a film state by cooling after a temperature controllable step at crystallization temperature (Tc) in the decreasing temperature process ±10° C.
US10253138B2	Polymer having unsaturated cycloaliphatic functionality and coating compositions therefrom A polymer is provided that preferably includes at least one unsaturated cycloaliphatic group. In one embodiment, the polymer is combined with an optional crosslinker and an optional carrier to form a coating composition suitable for use in coating articles such as packaging articles. In one embodiment, the polymer has at least one unsaturated cycloaliphatic group that is at least bicyclic.
US10253137B2	Hydrogenated tetracyclododecene-based ring-opening polymer and method for producing same The present invention is: a hydrogenated tetracyclododecene-based ring-opening polymer comprising a repeating unit (A) derived from tetracyclododecene in a ratio of 40 wt % or more based on a total amount of repeating units, a ratio of meso diads in the repeating unit (A) being 65% or more; and a method for producing the same. By means of the present invention, provided are: a crystalline hydrogenated tetracyclododecene-based ring-opening polymer having a high melting point and a high glass transition temperature, and exhibiting excellent heat resistance and excellent processability even after forming due to melt forming; and a method for producing the same.
US10253133B2	Urethane-group-containing reaction products A reaction product containing urethane groups, comprising one or more species of the general formula (I) (R1—X)p—Z1—(XH)y (I) where p+y=w and w is an integer from 2 to 10, p is an integer from 2 to 10, y is an integer from 0 to 8, and X is independently O, NH and/or NZ2 and XH is independently a hydroxyl group OH, a primary amino group NH2 and/or a secondary amino group NHZ2 where Z2 is independently a branched or unbranched, saturated or unsaturated organic radical G(U)a where U is independently a hydroxyl group, a primary amino group or a secondary amino group and a is an integer from 0 to 8, where w+a≤10, G is a branched or unbranched, saturated or unsaturated organic radical, the p R1 radicals are independently a radical of the general formula (II) Y—O—CO—NH—R2—NH—CO (II) in which the p Y radicals are independently a branched or unbranched, saturated or unsaturated organic radical which has 1 to 1000 carbon atoms and does not contain any hydroxyl groups, any primary amino groups or any secondary amino groups, the p R2 radicals are independently a branched or unbranched, saturated or unsaturated organic radical having 6 to 20 carbon atoms, and Z1 is a branched or unbranched, saturated or unsaturated organic radical which contains at least one tertiary nitrogen group and is free of XH groups.
US10253130B2	Block copolymer The present application provides the block copolymers and their application. The present application may provide the block copolymers that have excellent self assembling and phase separation properties and therefore that can be effectively used in various applications. The present application may also provide applications of the block copolymers.
US10253128B2	Crosslinking agent and fluorine-containing aromatic compound A crosslinking agent includes a compound represented by the following formula (1). In the formula (1), R1, R2, and R3 are independently a fluorine atom, an alkyl group, a fluoroalkyl group, or a substituted or unsubstituted aryl group, a plurality of R1 are identical or different, a plurality of R2 are identical or different, a plurality of R3 are identical or different, provided that at least one of R1, R2, and R3 is a fluorine atom or a fluorine atom-containing group, m is an integer of from 2 to 6, l is an integer of from 0 to 2, and each hydrogen on the benzene ring(s) is optionally substituted with a substituent.
US10253126B2	Optical waveguide-forming composition An optical waveguide-forming composition: 100 parts by mass of a reactive silicone compound (a) composed of a polycondensate of a diarylsilicic acid compound A of Formula [1] Ar1 and Ar2 are a phenyl, naphthyl or a biphenyl group optionally substituted, and an alkoxy silicon compound B of Formula [2] Ar3—Si(OR1)aR23-a [2]. Ar3 is a phenyl, naphthyl or biphenyl group having at least one group having a polymerizable double bond, R1 is methyl or ethyl group, R2 is methyl, ethyl, or vinylphenyl group, and a is 2 or 3, and 1 part by mass to 200 parts by mass of a di(meth)acrylate compound (b) of Formula [3]. R3 and R4 are a hydrogen atom or methyl group, R5 is a hydrogen atom, methyl group, or ethyl group, L1 and L2 are an alkylene group, and m and n are 0 or a positive integer, wherein m+n is 0 to 20.
US10253125B2	Polymerizable liquid crystal composition and optically anisotropic body, retardation film, and patterned retardation film using the same There is provided a polymerizable liquid crystal composition that enables a film formed through application of the composition and exposure thereof to heat or active energy rays to have an excellent molecular alignment and reduced haze. There is also provided an optically anisotropic body that is produced by using such a polymerizable liquid crystal composition and that has a good transparency. In particular, the present invention provides a polymerizable liquid crystal composition containing a polymerizable haze-reducing agent and a polymerizable liquid crystal compound. Furthermore, the present invention also provides an optically anisotropic body produced by using the polymerizable liquid crystal composition of the present invention. Using the polymerizable liquid crystal composition of the present invention enables production of an optically anisotropic body having a good transparency; hence, the polymerizable liquid crystal composition is usefully applied to optical materials used in, for example, retardation films.
US10253124B2	Copolymer having adjustable glass transition temperature and having usefulness as organic electro-optic polymer, and organic electro-optic element using the same An object of the present invention is to provide an organic EO polymer having a desired Tg. The present invention provides a copolymer comprising (i) a cycloalkane methacrylate and 2-isocyanatoethyl methacrylate as monomers at an adjusted blending ratio and (ii) an electro-optic molecule (EO molecule) bound to the copolymer, thereby exhibiting a desired glass transition temperature (Tg).
US10253121B2	Method of producing polyethylene and polyethylene thereof A system and method of producing polyethylene, including: polymerizing ethylene in presence of a catalyst system in a reactor to form polyethylene, wherein the catalyst system includes a first catalyst and a second catalyst; and adjusting reactor conditions and an amount of the second catalyst fed to the reactor to control melt index (MI), density, and melt flow ratio (MFR) of the polyethylene.
US10253120B2	Steam barrier resin, steam barrier coating agent, steam barrier film, and steam barrier laminate The present invention provides as steam barrier resin, a steam barrier coating agent, a steam barrier film, and a steam barrier laminate that exhibit an improved steam barrier property. The steam barrier resin is obtained by reacting a carboxylic acid group and/or an acid anhydride group of a copolymer (C) with an organometallic complex (D). The copolymer (C) is obtained by polymerizing an unsaturated hydrocarbon monomer (A) and an unsaturated carboxylic acid and/or an unsaturated dicarboxylic anhydride (B). Further, the steam barrier resin includes metal bridging between the copolymers (C). The steam barrier coating agent contains the steam barrier resin and a solvent (B). The steam barrier film of the present invention is a film containing the steam barrier. The steam barrier laminate is obtained by laminating the steam barrier film of the present invention on at least one surface of a substrate film.
US10253117B2	Process for producing diene polymers The invention describes a process for producing a diene polymer, the process including the following steps in this order i) polymerizing one or more diene monomers in the presence of a catalyst composition to give a reaction mixture; ii) adding to the reaction mixture one or more alkoxysilane compounds; iii) adding S2Cl2, SCl2, SOCl2, S2Br2, SOBr2 or a mixture thereof to the reaction mixture; and iv) optionally adding a protic agent to the reaction mixture so as to deactivate the catalyst. The invention further includes polymers that are obtainable according to this process, as well as products including the polymer.
US10253115B2	Process for the manufacture of a capacitor film Process for producing of a capacitor film comprising the steps of (a) polymerizing propylene in the presence of a catalyst comprising a solid catalyst system obtaining a polypropylene, (b) subjecting said polypropylene to a film forming process obtaining a capacitor film, wherein during the polymerization step (a) said catalyst comprising the solid catalyst system fragments into nanosized catalyst fragments being distributed in said polypropylene, said solid catalyst system comprises a transition metal, a metal which is selected from one of the groups 1 to 3 of the periodic table (IUPAC), and an internal electron donor.
US10253114B2	Polyolefin modified with nitrogen-containing heterocyclic compound, and adhesive composition containing same This invention provides a novel polyolefin modified with a nitrogen-containing heterocyclic compound containing no harmful halogen atoms such as chlorine, and an adhesive composition between a polyolefin substrate and an inorganic substrate such as a glass substrate. A polyolefin modified with a nitrogen-containing heterocyclic compound (C) having a nitrogen-containing heterocyclic compound (B) at the side chain of an acid-modified polyolefin (A).
US10253113B2	Method for activation of chromium containing catalyst precursor for polymerization and the resulting polymerization catalyst Method for activation of chromium containing catalyst precursor for polymerization and improved polymerization catalyst resulting The instant invention relates to an activation of a polymerization catalyst precursor by heat treatment comprising a support material and a catalyst precursor deposited thereon in a fluidized bed activator and to the use of the activated polymerization catalyst in the manufacture of polyolefins. The Method is performed in a cylindrical activator (1) arranged vertically comprising tubular activator walls, a fluidization gas inlet (2) near the bottom, a fluidization gas outlet (3) near the top and a heat exchange jacket (4) outside the tubular activator walls, wherein the heating jacket covers the complete outer surface of the walls of the activator. The catalyst prepared by that method is improved with respect to its minor content of impurities and causes less interruptions during gas-phase polymerization or slurry polymerization either in stirred vessel or loop.
US10253108B2	Mutated antibody of fully humanized HER2 antibody, and encoding gene and use thereof The present invention provides a mutated antibody of the fully humanized HER2 antibody GB235-019, wherein the amino acid sequence of the heavy chain variable region and the amino acid sequence of the light chain variable region of the mutated antibody are respectively SEQ ID NO: 10, SEQ ID NO: 2; SEQ ID NO: 11, SEQ ID NO: 2; or SEQ ID NO: 12, SEQ ID NO: 2. The mutated antibody has the ability to specifically bind to human HER2 antigen, similar to the GB235-019 antibody. They can also be used in combination with additional HER2 positive tumor therapeutic agents for treating HER2 positive tumor, weakly positive tumor or negative tumor.
US10253103B2	Antibody specifically binding to GLP-1R and fusion protein thereof with GLP-1 Disclosed in the present invention is an antibody specifically binding to GLP-1R and a fusion protein thereof with GLP-1. The fusion proteins can effectively bind to a human GLP-1R receptor and activate a receptor signaling pathway, thus are useful for treating diabetes, excessive weight, obesity and related disorders thereof.
US10253099B2	Conjugates of proteins and multivalent cell-penetrating peptides and their uses The present invention relates to conjugates comprising a protein and multivalent cell-penetrating peptide(s), each multivalent cell-penetrating peptide comprising at least two cell-penetrating peptides, wherein the multivalent cell-penetrating peptide(s) is/are covalently attached to the protein. The present invention furthermore relates to a method of generating the conjugates and to their medical uses, in particular their use in the diagnosis, prevention and/or treatment of diseases. The present invention relates to methods of diagnosis, prevention and/or treatment of diseases, comprising administering the conjugates of the invention to a patient.
US10253096B2	Anti-Tim-3 antibodies The present invention relates to antibodies that bind human T-cell immunoglobulin- and mucin-domain-containing protein-3 (Tim-3), and may be useful for treating solid and hematological tumors alone and in combination with chemotherapy and ionizing radiation.
US10253091B2	Antibody constant region variant By altering amino acid sequences, the present inventors successfully produced constant regions that can confer antibodies with particularly favorable properties for pharmaceutical agents. When used to produce antibodies, the altered constant regions produced according to the present invention significantly reduce heterogeneity. Specifically, the antibody homogeneity can be achieved by using antibody heavy chain and light chain constant regions introduced with alterations provided by the present invention. More specifically, the alterations can prevent the loss of homogeneity of antibody molecules due to disulfide bond differences in the heavy chain. Furthermore, in a preferred embodiment, the present invention can improve antibody pharmacokinetics as well as prevent the loss of homogeneity due to C-terminal deletion in antibody constant region.
US10253090B2	Hydrolyzed collagen compositions and methods of making thereof Disclosed herein are hydrolyzed collagen compositions. The compositions are inexpensive to make and can be produced without the use of proteolytic enzymes, decolorizing agents, antibacterial and antifungal agents, and the like. Further, the compositions are substantially free of odors and are white to light yellow in color and are suitable to be used as dietary supplements. Also disclosed are methods for producing the compositions.
US10253088B2	Modified von Willebrand Factor The present invention provides a modified polypeptide which binds Factor VIII. The modified polypeptide comprises a sequence as shown in SEQ ID NO:3 in which the sequence comprises at least a modification at position 1 or 3 such that the modified polypeptide binds to Factor VIII with an off rate at least 5 fold lower than a reference polypeptide comprising an unmodified SEQ ID NO:3.
US10253086B2	CD20 therapies, CD22 therapies, and combination therapies with a CD19 chimeric antigen receptor (CAR)-expressing cell The invention provides compositions and methods for treating diseases associated with expression of CD19, e.g., by administering a recombinant T cell comprising the CD19 CAR as described herein, in combination with one or more B-cell inhibitors, e.g., inhibitors of one or more of CD10, CD20, CD22, CD34, CD123, FLT-3, ROR1, CD79b, CD179b, or CD79a. The disclosure additionally features novel antigen binding domains and CAR molecules directed to CD20 and CD22, and uses, e.g., as monotherapies or in combination therapies. The invention also provides kits and compositions described herein.
US10253085B2	CD31 peptides for the treatment of thrombotic or autoimmune disorders The present invention stems from the finding that the extracellular domain of CD31 proteins present on blood leukocytes is shed and released in the circulation as a soluble form of CD31. The invention relates to peptides corresponding to fragments of CD31 that inhibit T-cell response, and to their use in the treatment of thrombotic disorders such as atherothrombosis and autoimmune disorders.
US10253084B2	Methods for predicting three-dimensional structures for alpha helical membrane proteins and their use in design of selective ligands A method for practical prediction of the three-dimensional structure of α-helical membrane proteins (HMPs) is described. The method allows one to predict the binding site and structure for strongly bound ligands. The method combines a protocol of computational methods enabling a complete ensemble of packings to be sampled and systematically reducing this ensemble to progressively more accurate structures until at the end there remain a few that might be functionally relevant and likely to play a role in all binding and activation processes. This method is well suited to automatic operation making it practical to obtain, for example, the ensemble of important structures for all human GPCRs. With this ensemble of all active GPCR structures in the human body, an infimum method is presented to maximize efficacy toward the selected target while minimizing binding to all other GPCRs to eliminate toxicity arising from cross-reacting with other GPCRs (a most common source of drug failure). This infimum method is broadly applicable to any set of proteins where a ligand is desired to be able to modulate the function of one protein while not affecting the function of other proteins.
US10253078B2	GIP agonist compounds and methods The present invention relates to acylated GIP analogs which have GIP agonist activity, and their use in the treatment of metabolic disorders.
US10253072B2	Prophylactic vaccine against egg drop syndrome (EDS) The present invention is intended to provide an egg drop syndrome (EDS) vaccine that is capable of effectively preventing EDS and can be stably supplied. The EDS vaccine provided to this end contains as an active ingredient fused protein in which a polypeptide having a coiled-coil forming unit is bound to the knob region in the fiber protein of EDS virus (EDSV).
US10253067B2	Peptidomimetic macrocycles and uses thereof Methods for treating liquid cancer, determined to lack a p53 deactivation mutation, in a subject are provided. Also provided are peptidomimetic macrocycles for use in treatment of a liquid cancer, determined to lack a p53 deactivation mutation, in a subject.
US10253064B2	Purification method, purification kit, and silicon oxide-binding tag for use therein The present invention provides a method for purifying an intended substance, a kit for purifying the intended substance, and a silicon oxide-binding tag for use in the method and the kit. In the present invention, a complex of a silicon oxide-binding tag and a substance is caused to specifically bind to silicon oxide in a solution for binding, to which solution no salt is added, and binding between the silicon oxide-binding tag and the silicon oxide is broken with use of arginine.
US10253059B2	Hybrid galactoside inhibitor of galectins The present invention relates to a compound of the general formula (1). The compound of formula (1) is suitable for use in a method for treating a disorder relating to the binding of a galectin, such as galectin-3 to a ligand in a mammal, such as a human. Furthermore the present invention concerns a method for treatment of a disorder relating to the binding of a galectin, such as galectin-3 to a ligand in a mammal, such as a human.
US10253058B2	Alkylglycoside sulfomethylsuccinate surfactants The present invention relates to an alkyl glycoside sulfomethylsuccinate having the formula R1-O-Sn-R2 wherein R1 is an alkyl radical having 6 to 30 carbon atoms, S is a monosaccharide moiety, and R2 is a sulfomethylsuccinate moiety. Furthermore the present invention relates to a process for making this alkyl glycoside sulfomethylsuccinate and to an alkyl glycoside itaconate which is a useful intermediate for use in this process. Furthermore the present invention relates to a cosmetic composition comprising the alkyl glycoside sulfomethylsuccinate and to the use of the alkyl glycoside sulfomethylsuccinate for improving the foam stability of a cosmetic composition.
US10253057B2	Method of coalescing a substance Provided is a method of coalescing a substance comprising providing a first mixture comprising a substance, agitating at least a portion of the first mixture under turbulent conditions for a first time period, thereby causing particles comprising and substance to collide and form into larger particles.
US10253056B2	Complexes A palladium(II) complex of formula (1) or a palladium(II) complex of formula (2). Also, a process for the preparation of the complexes, and their use in carbon-carbon and carbon-heteroatom coupling reactions.
US10253050B2	Fluorinated cycloalkene functionalized silicas Fluorinated cyclopentene moieties and fluorinated cyclopentene functionalized silica materials are provided. The fluorinated cyclopentene functionalized silica materials include a silica material having the fluorinated cyclopentene moiety covalently bonded thereto. Exemplary silica materials include a polysilsesquioxane, a nanosilica, a microsilica, a silica gel, a silica aerogel, or combinations thereof. The fluorinated cyclopentene moieties are based on a modification of perfluorocyclopentene (i.e., 1,2,3,3,4,4,5,5-octafluoro-1-cyclopentene) by nucleophilic substitution with an appropriate nucleophile having a reactive functional group. Methods for preparing fluorinated cyclopentene moieties and the corresponding fluorinated cyclopentene functionalized silica materials are also provided.
US10253048B2	Tunable rare-earth fcu-metal-organic frameworks Metal organic framework compositions can have a face centered cubic structure.
US10253046B2	TYK2 inhibitors and uses thereof The present invention provides compounds, compositions thereof, and methods of using the same for the inhibition of TYK2, and the treatment of TYK2-mediated disorders.
US10253042B2	N-(2-(2-amino-6-substituted-4,4a,5,6-tetrahydropyrano[3,4-d][1,3]oxazin-8a(8H)-YL)-thiazol-4-YL) amides The present invention is directed to compounds, tautomers and pharmaceutically acceptable salts of the compounds which are disclosed, wherein the compounds have the structure of Formula I, wherein the variables R1, R2, R3, R4 and X are as defined in the specification. Corresponding pharmaceutical compositions, methods of treatment, methods of synthesis, and intermediates are also disclosed.
US10253040B1	MK2 inhibitors and uses thereof The present invention provides compounds, compositions thereof, and methods of using the same.
US10253039B2	Inhibitors of bacterial DNA gyrase with efficacy against gram-negative bacteria The present invention provides N-benzyl-3-sulfonamidopyrrolidines and related compounds, as well as pharmaceutical compositions and sanitizing compositions containing the same. The compounds and compositions are useful as antibiotic agents. Methods for making and using the compounds and compositions are also described.
US10253038B2	Fusicoccane derivatives and methods Provided are fusicoccane derivatives and methods of making fusicoccane derivatives. The methods may include contacting a tethered chromophore with light to initiate a photoinduced pericyclic reaction cascade to form a 5-8-5 carbotricycle. The 5-8-5 carbotricycle may be further functionalized.
US10253036B2	Crystalline forms of therapeutic compounds and uses thereof Described herein are crystalline forms of Compound 1 useful for the prevention and treatment of angiogenic ocular conditions; methods of treating a disease comprising; processes for preparing; and kits comprising, the same.
US10253033B2	De novo synthesis of bacteriochlorins A method of making a bacteriochlorin is carried out by condensing a pair of compounds of Formula II to produce the bacteriochlorin, wherein R is an acetal or aldehyde group. The condensing may be carried out in an organic solvent, preferably in the presence of an acid. The bacteriochlorins are useful for a variety of purposes such as active agents in photodynamic therapy, luminescent compounds in flow cytometry, solar cells, light harvesting arrays, and molecular memory devices.
US10253031B2	Stable pemetrexed arginine salt and compositions comprising it The present invention relates to arginine salt of pemetrexed of formula (1), particularly to a stable solid form thereof, and to pharmaceutical compositions comprising such salt.
US10253030B2	Crystal form, preparation method and intermediate of dihydropyrido ring compound Disclosed in the present disclosure are a crystal form of a dihydropyrido ring compound, and preparation method and intermediate thereof.
US10253029B2	Dual-warhead covalent inhibitors of FGFR-4 The disclosure includes compounds of Formula (I) wherein Warhead1, Warhead2, R3, R4, R5, R6, R7, R8, Q, A, B, p, q, Z1, Z2, Z3, and Z4 are defined herein. Also disclosed is a method for treating a neoplastic disease with these compounds.
US10253028B2	Pyrazolo[3,4-D]pyrimidin derivative and its use for the treatment of leishmaniasis The compound 3,3,3-trifluoro-N-((1,4-trans)-4-((3-((S)-2-methylmorpholino)-IH-pyrazolo[3,4-d]pyrimidin-6-yl)amino)cyclohexyl)propane-1-sulfonamide having the Formula (I) or a salt thereof, its opposite enantiomer, compositions comprising the compound and its use in the treatment or prevention of leishmaniasis, particularly visceral leishmaniasis.
US10253024B2	Polycyclic indoline and indolenine compounds The present invention relates to indoline and indolenine alkaloid compounds. In particular, indoline and indolenine alkaloid compounds of the invention have antibacterial activity and/or are capable of re-sensitizing the susceptibility of methicillin-resistant S. aureus to a β-lactam antibiotic. The present invention also relates to a method for producing and using the same.
US10253017B2	Derivatives of 2-aminopyridine as adenosine A2B receptor antagonists and ligands of the melatonin MT3 receptors The present invention relates to novel pyridine derivatives of formula (I): as A2B adenosine receptor antagonists and ligands of MT3 melatonin receptor, to processes for their preparation, to pharmaceutical compositions comprising said compounds and to the use of said for manufacturing a medicament for the treatment of pathological conditions or diseases that can improve by antagonizing the adenosine A2B receptor and by inhibition of MT3 melatonin receptor, such as respiratory disease, metabolic disorders, neurological disorders and cancer.
US10253016B2	Heterocyclic compound and organic light-emitting device comprising same The present specification provides a heterocyclic compound and an organic light emitting device comprising the same.
US10253014B2	Cyclic amine derivative and pharmaceutical use thereof A cyclic amine derivative represented by a general formula (I) or a pharmacologically acceptable salt thereof: wherein n represents 1 or 3, R1 represents an alkyl group having 1 to 6 carbon atoms unsubstituted, substituted with a halogen atom or substituted with an alkyloxy group having 1 to 4 carbon atoms and R2 represents a hydrogen atom or a halogen atom.
US10253008B2	Method for producing furan compound and furfural composition The present invention is aimed to provide an industrially advantageous method for producing a furan compound, in which a furan compound can be efficiently obtained in a high selectivity from a furfural compound. The present invention is concerned with a method for producing a furan compound including feeding, as a raw material, a furfural composition containing a furfural compound into a reactor and subjecting to a decarbonylation reaction in the presence of a catalyst to obtain a furan compound as a product, wherein a furfural dimer concentration in the furfural composition is 1,000 ppm by weight or less, and a peroxide value in the furfural composition is 0.01 mEq/kg or more and 1.0 mEq/kg or less.
US10253004B2	Indanylaminopyrazinylcyclopropanecarboxylic acids, pharmaceutical compositions and uses thereof The present invention relates to compounds of formula I, wherein the groups R, R1, R2, R3, m and n are defined herein, which have valuable pharmacological properties, in particular bind to the GPR40 receptor and modulate its activity. The compounds are suitable for treatment and prevention of diseases which can be influenced by this receptor, such as metabolic diseases, in particular diabetes type 2. Furthermore, the invention relates to novel intermediates, useful for the synthesis of compounds of formula I.
US10253001B2	Method for preparing azoxystrobin and its intermediates The present invention discloses a method for preparing azoxystrobin intermediates represented by formulae (1) and (2), comprising: controlling a compound represented by formula (3) to contact with sodium methoxide and 4,6-dichloropyrimidine, to obtain a mixture of intermediates represented by formulae (1) and (2), in the existence of a catalyst, the catalyst is an azabicyclic compound or its salt. The present invention further discloses a method for preparing azoxystrobin, comprising: controlling the intermediate represented by formula (2) provided in the present invention to react with 2-cyanophenol or its salt under the catalytic action of an azabicyclic compound or its salt, to obtain an azoxystrobin compound represented by formula (4). The method provided in the present invention has advantages including high transformation ratio, high product purity, easy and convenient operation, and environmental friendliness.
US10253000B2	Pyridazin-3(2H)-one derivatives as monoamine oxidase selective isoform B inhibitors The present invention refers to pyridazin-3(2H)-one derivatives of general structure I, II and III, which are selective MAO-B inhibitors, and to the use thereof for preparing medicaments intended to treat disorders derived from MAO-B hyperactivity, particularly degenerative disorders of the central nervous system (CNS), such as Parkinson's disease (PD), Alzheimer's disease (AD) and other dementias. These are pyridazin-3(2H)-one derivatives having dithiocarbamate moieties bonded to position 4, 5 or 6 through an alkyl chain of variable length (n=1, 2, 3). This invention is also directed to the preparation of said compounds.
US10252997B2	Monocyclic compound The present invention relates to a compound which may be useful as an agent for the prophylaxis or treatment of cancer, hepatitis, hepatic fibrosis, fatty liver and the like.
US10252992B2	Urea derivative or pharmacologically acceptable salt thereof Provided is a compound having a formyl peptide receptor like 1 (FPRL1) agonist effect.The present invention relates to a compound represented by the general formula (I) or a pharmacologically acceptable salt thereof. The present invention also relates to a pharmaceutical composition containing the compound represented by the general formula (I) or a pharmacologically acceptable salt thereof.
US10252990B2	Process for the preparation of 2-alkyl-4-trifluoromethyl-3-alkylsulphonylbenzoic acids by chemoselective thioether oxidation A process for the preparation of 2-alkyl-4-trifluoromethyl-3-alkylsulfonylbenzoic acids of the formula (I) is described. Herein, the substituents are radicals such as alkyl and substituted phenyl.
US10252989B2	Picolinamides with fungicidal activity The invention relates to picolinamides of Formula I and their use as fungicides.
US10252988B2	Composition for producing transparent polythiourethane bodies The invention relates to a composition for producing transparent polythiourethane bodies containing or consisting of A) a polyisocyanate component containing at least one polyisocyanate with a functionality of isocyanate groups of at least 2 per molecule, B) a thiol component containing at least one polythiol with a functionality of thiol groups of at least two per molecule, in addition to optionally C) auxiliary agents and additives, the ratio of isocyanate groups to groups reactive in relation to isocyanates being 0.5:1 to 2.0:1. The composition is characterized in that the polyisocyanate of the polyisocyanate component A) is produced by a gas-phase phosgenation of aliphatic, cycloaliphatic, aromatic or araliphatic polyamines. The invention also relates to a method for producing transparent polythiourethane bodies by the conversion of a composition of this type, to polythiourethane bodies produced in this manner and to the use of polyisocyanates, produced by a gas-phase phosgenation of aliphatic, cycloaliphatic, aromatic or araliphatic polyamines, for producing transparent polythiourethane bodies.
US10252987B2	Type of antiviral compound Provided are a new aromatic cyanogen compound and a preparation method thereof. The present invention also relates to the use of such compound in antiviral drugs, in particular the use thereof in anti-HCV drugs.
US10252984B2	Inhibiting G protein coupled receptor 6 kinase polypeptides This document relates to inhibitors of G protein coupled receptor 6 kinase (GRK6) polypeptides as well as methods and materials for using such inhibitors to treat hematological malignancies, inflammation diseases, and autoimmune disorders.
US10252981B2	Methods of synthesis of (1R,2R,5R)-5-amino-2-methylcyclohexanol hydrochloride and intermediates useful therein Provided herein are methods and intermediates for making (1R,2R,5R)-5-amino-2-methylcyclohexanol hydrochloride, which are useful for the preparation of compounds useful for the treatment of a disease, disorder, or condition associated with the JNK pathway.
US10252977B2	Halogen-substituted phenoxyphenylamidines and the use thereof as fungicides The present invention relates to halogen-substituted phenoxyphenylamidines of the general formula (I), to a process for their preparation, to the use of the amidines according to the invention for controlling unwanted microorganisms and also to an agrochemical formulation for this purpose, comprising the halogen-substituted phenoxyphenylamidines according to the invention. Furthermore, the invention relates to a method for controlling unwanted microorganisms by applying the compounds according to the invention to the microorganisms and/or their habitat.
US10252974B2	Cationic lipid The present invention provides a technology which enables introduction of an active ingredient (e.g. nucleic acids) into various cells with a high efficiency, and compounds used therefor. The present invention provides a compound represented by the formula: [wherein, each symbol is as defined in the present description] or a salt thereof.
US10252970B2	Method of dehydrating 3-hydroxypropionic acid to form acrylic acid The invention relates to a process for dehydrating aqueous 3-hydroxypropionic acid to acrylic acid in the liquid phase, wherein aqueous acrylic acid is removed continuously from the liquid phase and the aqueous 3-hydroxypropionic acid and/or the liquid phase have a high content of oligomeric 3-hydroxypropionic acid.
US10252968B2	Process for making cyclohexanone Disclosed are novel processes for making cyclohexanone compositions, from a mixture comprising phenol, cyclohexanone, and cyclohexylbenzene. The process includes hydrogenation of a feed stream comprising phenol, cyclohexanone, and cyclohexylbenzene. The feed stream may be subjected to one or more pre-hydrogenation treatments, such as passing through one or more sorbents, addition of basic chemical agents, and/or addition of water, so as to improve catalyst activity, minimize undesired side reactions, and/or remove catalyst poisons from the feed stream. The feed stream may be provided to a hydrogenation reaction zone in the vapor phase, with periodic alterations to hydrogenation reaction conditions such that the feed is provided in mixed liquid and vapor phase in order to carry out liquid washing of a hydrogenation catalyst bed within the hydrogenation reaction zone.
US10252965B2	Vinylbenzylated phenol compound, method of manufacturing vinylbenzylated phenol compound, activated ester resin, method of manufacturing activated ester resin, thermoset resin composition, hardened material of thermoset resin composition, interlayer insulating material, prepreg, and method of manufacturing prepreg A vinylbenzylated phenol compound represented by General Formula (1) below is provided. (In General Formula (1), Ar0 is a bifunctional phenol compound residue having one or more monocyclic or polycyclic aromatic nuclei, R1 to R5 may be the same or different and are each hydrogen or a methyl group, and p is an integer of 1 to 4.)
US10252964B2	Producing method for 4-isopropyl-3-methylphenol The main object of the present invention is to provide a producing method for a 4-isopropyl-3-methylphenol which may be selectively produced, easily refined, and with less odor and coloration. The present invention achieves the object by providing a producing method for a 4-isopropyl-3-methylphenol characterized in that a 4-halogenated-3-methylphenol or a phenol derivative thereof is reacted with an isopropyl metal compound under presence of a catalyst and a solvent.
US10252961B2	One vessel process for making 1,2-propanediol from a high fructose feedstock A process is described for directly converting a high fructose feedstock to a product mixture including one or more lower polyols in which 1,2-propanediol is produced in preference to any other lower polyols, wherein a high fructose feed and a source of hydrogen are supplied to a reaction vessel and reacted in the presence of a copper-containing, supported ruthenium catalyst to provide the product mixture.
US10252956B2	Viscosity modifiers for decreasing the viscosity of ionic liquids A process utilizing an ionic liquid is described. The process includes contacting a hydrocarbon feed with an ionic liquid component, the ionic liquid component comprising a mixture of a first ionic liquid and a viscosity modifier, wherein a viscosity of the ionic liquid component is at least about 10% less than a viscosity of the first ionic liquid.
US10252954B1	Multi-layered stable propellant composition The present invention is directed to propellant grains having multiple layers consisting of an outer, slow burning, layer composition and an inner, fast burning, layer with desirable progressivity burn rates. The outer, slow burning, layer comprising a first energetic material, a first plasticizer and a first binder and an inner, fast burning, layer comprising a second energetic material, and the same plasticizer as the outer layer, and a second binder. The compositions in the propellant grain provided herein provides for a burn rate energy differential between the outer, slow burning, layer and inner, fast burning, layer of at least 2.
US10252953B2	Nanoenergetic material composite having remote ignition characteristic A nanoenergetic material composite having a remote ignition characteristic by a high-power pulsed laser beam is prepared by adding various contents of multiwalled carbon nanotubes (MWCNTs) to a nanoenergetic composite material (nEM) to enable remote ignition by a high-power laser beam. The nanoenergetic material composite is a MWCNT/nEM composite powder prepared by adding multiwalled carbon nanotubes to the nanoenergetic material, which is a mixture of fuel material nanoparticles and metal oxidizer nanoparticles, wherein the multiwalled carbon nanotubes enhance a combustion rate of the MWCNT/nEM composite powder by delivering thermal energy upon remote optical ignition by the high-power pulsed laser beam.
US10252950B2	Methods and compositions for digestion of organic waste The present invention relates to a process wherein organic material derived from plant and animal material is processed to recover nutritional elements. In particular, there is provided a process for releasing nutritional elements from plant and animal material comprising the steps of treating the material with one or more enzymes to digest said material under appropriate conditions and separating the resulting liquid hydrolysate from the undigested material.
US10252945B2	Bioceramic compositions This invention relates to compositions and applications for a bioceramic composition that includes from about 45 to about 55% by weight of kaolinite (Al2Si2O5(OH)4); from about 5 to about 15% by weight of tourmaline; from about 3 to about 13% by weight of aluminum oxide (Al2O3); from about 11 to about 19% by weight of silicon dioxide (SiO2); and from about 3 wt % to about 13 wt % zirconium oxide (ZrO2).
US10252944B2	Honeycomb structure and manufacturing method of honeycomb structure A honeycomb structure includes a cordierite component, and has partition walls defining a plurality of cells which extend from one end face to the other end face and form through channels for a fluid, a thermal expansion coefficient in a central axis direction is 1.2 ppm/K or more and 3.5 ppm/K or less in a temperature change of 40° C. to 800° C., and a thermal expansion coefficient in a cross-sectional direction orthogonal to the central axis direction is 0.8 ppm/K or more and 2.5 ppm/K or less in the temperature range of 40° C. to 800° C.
US10252942B2	Fiber containing aqueous foam composite, the process and use Foamed fiber compositions and processes of making said compositions. Compositions include a hydraulic mixture including (i) a polymer and (ii) one or more of gypsum, fly ash, and cement; and a foam including a foaming agent, a foam stabilizer, and 0.5-35% fibers by weight. The process for forming the foamed fiber composition includes providing a stable foam including a foaming agent and a foam stabilizer; mixing fibers into the stable foam until the fibers are uniformly distributed in the foam to form a fiber-containing foam, wherein the fiber-containing aqueous foam contains 0.5-35% fibers by weight; and mixing the fiber-containing foam into a hydraulic slurry including (i) a polymer and (ii) one or more of gypsum, fly ash, and cement. The composition is suitable for use in roof tiles, underlayments, backerboards, cement composites, foam fills, bricks, cement sidings, etc.
US10252941B2	Method for making strengthened glass having reduced induced curvature using differential chemistry Chemically strengthened glass and a method for making utilizing differential chemistry are provided. The method includes providing a substrate having a glass chemical structure. Host alkali ions are situated in the chemical structure. The substrate has a treatment-rich volume and a treatment-poor volume located as opposed to each other in the substrate. The method also includes providing an exchange medium characterized by including a composition associated with an ion exchange rate of invading alkali ions having an average ionic radius that is larger than an average ionic radius of the host alkali ions. The method also includes providing a modified exchange medium including a modified composition associated with a modified ion exchange rate of the invading alkali ions. The method also includes applying the exchange mediums and conducting ion exchange to produce the strengthened substrate.
US10252939B2	High-hardness transparent glass ceramic and preparation method therefore A high-hardness transparent glass ceramic and a preparation method therefor, wherein the components by weight percentage include: 55.0%-70.0% of SiO2, 15.0%-20.0% of Al2O3, 0%-10.0% of MgO, and 0%-12.5% of ZnO, necessarily including one of MgO or ZnO, and the crystallized glass thereof contains microcrystals of spinel crystal. In the present invention, a suitable precursor glass is subjected to thermal treatment, and microcrystals are separated from the glass substrate by crystallization, producing a glass ceramic having a Moh's hardness greater than 7 and a visible-light transparency rate greater than 80% through 1 mm of the glass. The glass ceramic of the invention overcomes the problem that ordinary optical glass is easy to be scratched. The present glass ceramic can be served as protective face for mobile phones, protective glass for optical instruments and in communications equipment, substrate for magnetic disks, LCD panel, or protective glass for other optoelectronic devices.
US10252938B2	Glass composition, glass frit containing same, glass paste containing same, and electrical/electronic component obtained using same The present invention aims at providing a lead-free glass composition that can be soften and flowed at a firing temperature that is equal to or lower than that of conventional low melting point lead glass. Furthermore, the present invention aims at providing a lead-free glass composition having fine thermal stability and fine chemical stability in addition to that property. The lead-free glass composition according to the present invention is characterized by comprising at least Ag2O, V2O5 and TeO2 when the components are represented by oxides, wherein the total content ratio of Ag2O, V2O5 and TeO2 is 75 mass % or more. Preferably, the lead-free glass composition comprises 10 to 60 mass % of Ag2O, 5 to 65 mass % of V2O5, and 15 to 50 mass % of TeO2.
US10252936B2	Near-infrared cut filter glass A near-infrared cut filter glass includes: P, Al, R (R represents any one or more of Li, Na, and K), R′ (R′ represents any one or more of Mg, Ca, Sr, Ba, and Zn), and Cu, and not including F practically, wherein (Cu+ amount/total Cu amount)×100[%] is 0.01 to 7.0%. The filter glass may further include, by mol %, 0 to 10% B2O3. The filter glass may have a fracture toughness value of the near-infrared cut filter glass is 0.3 MPa·m1/2 or more. For the filter glass, a quotient obtained by dividing an absorption constant at a wavelength of 430 nm by an absorption constant at a wavelength of 800 nm, of the near-infrared cut filter glass, may be 0.00001 to 0.19.
US10252934B2	Optical glass, glass preform and optical element A high-refraction low-dispersion optical glass with refractive index of 1.77-1.85 and Abbe number of 40-48, includes the following components by mole percentage: 5-25% of SiO2, 15-45% of B2O3, 5-25% of La2O3, 1-20% of Gd2O3, 0-10% of Y2O3, 0-8% of TiO2, 0-8% of Ta2O5, more than 0 but less than or equal to 8% of Nb2O5, more than 0 but less than or equal to 15% of ZrO2, 18-40% of ZnO and 0.28-1.2 of SiO2/B2O3. The invention reduces the content of Ta2O5 and optimizes the cost of raw materials. Through rational composition design, the optical glass of the invention is conducive to precision molding while achieving the required optical constant, with excellent chemical stability. A glass preform and an optical element made of the optical glass are also disclosed.
US10252928B2	Method for reducing cyanuric acid in recreational water systems The present invention provides compositions and methods of reducing cyanuric acid levels in recreational water systems.
US10252926B2	Wastewater treatment process for removing chemical oxygen demand This disclosure provides methods and compositions for removing COD-causing contaminants from water, such as cosmetic product manufacturing wastewater and personal care product manufacturing wastewater. The methods involve controlling system parameters in order to hold iron as an iron(II) species. Iron(II) has increased solubility and therefore is more active against the specific contaminants present in the wastewaters.
US10252925B2	Method and apparatus for conditioning fluids Methods are disclosed including increasing the rate by which a dissimilar material separates in an aqueous-based mixture, comprising passing a first aqueous-based mixture through a magnetically conductive conduit having magnetic energy directed along the longitudinal axis of the magnetically conductive conduit and extending through at least a portion of the first aqueous-based mixture thereby providing a conditioned aqueous-based medium; and separating the conditioned aqueous-based medium into at least two distinct phases in at least one separation apparatus downstream of the magnetically conductive conduit, wherein the at least one dissimilar material separates from water in the conditioned aqueous-based medium at an increased rate as compared to a rate of separation of the at least one dissimilar material from water in the first aqueous-based mixture.
US10252924B2	Purification of ultra-high saline and contaminated water by multi-stage ion concentration polarization (ICP) desalination A water stream is passed between two juxtaposed similar ion exchange membranes (AEMs or CEMs), forming an ion depletion and ion enrichment zones when an electric field is applied. As cations are selectively transferred through the CEMs, for example, anions are relocated in order to achieve electro-neutrality, resulting in the concentration drop (increase) in ion depletion (enrichment) zone. Trifurcation of the output channel allows collection of concentrated, dilute and intermediate streams, with the intermediate stream serving as input to the next stage of a serialized implementation.
US10252922B2	Electrolysis device Disclosed is an electrolysis device including: an electrolyzing tank generating electrolyzed water and hydrogen gas as by-product gas by electrolyzing raw water supplied from a raw water supply unit; and a catalyst reaction tank having therein a hydrophobic catalyst, and receiving the hydrogen gas generated from the electrolyzing tank, and removing the hydrogen gas by a catalyst reaction.
US10252920B2	Flowfield sensors for monitoring liquid flow Data relating to fluid dynamics is obtained using a flow field sensor that measures acceleration and angular velocity of the sensor on three axes. Ballast control allows the sensor to obtain neutral buoyancy within the fluid. The sensor is effective in opaque fluids and closed containers as data is stored in a removable memory. Froth flotation systems are among the applications for the sensor. The small size, the geometry, and the center of mass of the sensor allow it to follow the flow field in a vessel without material disruption of the flow field or weight-induced angular displacement.
US10252919B2	Highly pure powder intended for thermal spraying Powder of particles, more than 95% by number of said particles exhibiting a circularity greater than or equal to 0.85, wherein said powder contains more than 99.8% of a rare earth oxide and/or of hafnium oxide and/or of yttrium aluminum oxide, as percentage by weight relative to the oxides, and has: a median particle size D 50 of between 10 and 40 microns and a size dispersion index (D 90−D 10)/D 50 of less than 3; a percentage by number of particles having a size less than or equal to 5 μm which is less than 5%; an apparent-density dispersion index (P<50−P)/P of less than 0.2, the cumulative specific volume of the pores which have a radius of less than 1 μm being less than 10% of the apparent volume of the powder, in which the percentiles Dn of the powder are the particle sizes corresponding to the percentages, by number, of n %, on the curve of cumulative distribution of the particle size of the powder, the particle sizes being classified in increasing order, the density P<50 being the apparent density of the fraction of particles having a size less than or equal to D50, and the density P being the apparent density of the powder.
US10252918B2	EMM-28, a novel synthetic crystalline material, its preparation and use A novel synthetic crystalline material, EMM-28, can be synthesized in the presence of an organic structure directing agent (Q) selected from one or more of the following dications: EMM-28 may be used in organic compound conversion reactions and sorptive processes.
US10252917B2	Method for preparing Y type molecular sieve having high silica to alumina ratio Provided is a method for preparing a Y type molecular sieve having a high silica-to-alumina ratio, comprising: mixing deionized water, a silicon source, an aluminum source, an alkali source, and a tetraalkylammoniumcation source as a template agent to obtain an initial gel mixture; after aging the initial gel mixture at an appropriate temperature, feeding the gel mixture into a high pressure synthesis kettle for crystallization; separating a solid product, and drying to obtain the Y type molecular sieve having a high silica-to-alumina ratio. The method provides a phase-pure Y type molecular sieve having a high crystallinity, the SiO2/Al2O3 thereof being not less than 6.
US10252911B2	Auto thermal reforming (ATR) catalytic systems An autothermal reforming catalytic structure for generating hydrogen gas from liquid hydrocarbons, steam and an oxygen source. The autothermal reforming catalytic structure includes a support structure and nanosized mixed metal oxide particles dispersed homogenously throughout the support structure.
US10252906B2	Package for MEMS device and process The application describes a package design for a MEMS transducer having an integrated circuit mounted within a chamber of the package. The integrated circuit may extend into a side wall recess of the package.
US10252905B2	Semiconductor device and method of manufacturing the same A semiconductor device includes a substrate, a beam, a movable structural body, a first stopper member, a second stopper member and a third stopper member. The first stopper member is arranged with a first gap from the movable structural body in an in-plane direction. The second stopper member is arranged with a second gap from the movable structural body in an out-of-plane direction. The third stopper member is arranged opposite to the second stopper member with the movable structural body interposed therebetween in the out-of-plane direction, and is arranged with a third gap from the movable structural body. Consequently, there can be provided a semiconductor device in which excessive displacement of the movable structural body can be suppressed to thereby suppress damage to and breakage of the beam supporting the movable structural body, and a method of manufacturing the same.
US10252902B2	Beverage dispensing appliance comprising a cooling unit An appliance for dispensing a beverage is disclosed. The appliance has a housing that defines an inner space for a beverage keg. The keg extends along a gravitational direction, X1, parallel to the gravity field, from a top position to a bottom position, wherein the top position is higher in the gravity field than the bottom position when the appliance is in use. A pressure unit pressurizes the interior of the keg. A tap unit dispenses beverages from the keg driven by pressure. A cooling unit cools the beverage in the keg. The cooling unit is suitable for cooling a specific cold area of the keg's outer wall to a temperature lower than any other point of the keg. The cold area of the keg is located in the top third portion of the keg according to the X1 direction.
US10252900B2	Apparatuses, systems, and methods for dispensing beverages using alcoholic concentrates A beverage dispenser includes a gas infusion device that receives a base fluid and a gas and dispenses a gas infused liquid, a ratio pump that receives the gas infused liquid and a concentrate from a concentrate source and dispenses a predetermined ratio of the gas infused liquid and the concentrate, and a mixing chamber that mixes the predetermined ratio of the gas infused liquid and the concentrate to form a reconstituted beverage. An insulated enclosure has an interior space in which the ratio pump and the mixing chamber are positioned. A cooling heat exchanger is positioned in the insulated enclosure, and a first refrigeration system circulates a cooling media through the cooling heat exchanger to thereby cool the interior space to a suitable temperature such that the gas infused liquid and the concentrate dispensed from the ratio pump and the mixing chamber are cooled to the suitable temperature.
US10252898B2	Plant for applying protective membranes on beverage cans A rotating plant for the application of protective membranes of a stretchable plastic polymer on the upper rim of beverage cans includes equal operating devices movable along radial trajectories of a turntable that provide for the circular movement, the radial movement and the vertical movement required and sufficient for applying the membranes.
US10252897B2	Self-sealing bottle holder A bottle holder that automatically seals a bottle opening when the bottle holder is placed for storage. The bottle may rest within a recess of the holder base, and the nozzle of the bottle is held in place by a nozzle catch that is conically shaped and has an inner cup that tapers to a terminal point so that a nozzle that it placed within will be sealed by the inner wall of the cup. The nozzle catch is spring loaded and presses down against the bottle to hold it in place and maintain a seal on the nozzle. A bottle may be placed in the holder by positioning a nozzle in the nozzle catch on the upper side of the holder and pushing upwards and inwards, which causes the spring to compress and allows the bottle bottom to pass over the base and into the recess.
US10252895B2	Solar array lifter and method A solar array lifting assembly and method. The device and method use a support pole, a pole bracket for supporting a solar array made up of a frame and solar panels, a pole bracket securing mechanism for securing the pole bracket at a predetermined height, and a lifting assembly for lifting the pole bracket and solar array along the support pole.
US10252889B2	Method of installing a machine in an elevator system A method for installing an elevator drive machine in a machine room-less elevator system is provided. A drive machine assembly is fastened to a counterweight. The counterweight is then lifted vertically along a set of counterweight guide rails to the top of the hoistway. There, the drive machine assembly is mounted to the ends of the counterweight guide rails. Once in place, the drive machine assembly is then disconnected from the counterweight.
US10252888B2	Drive machine for an elevator and an elevator A drive machine for an elevator includes a motor module including at least a motor, a drive shaft, and a first transmission wheel, which are provided with a common rotational axis and connected coaxially to each other. The drive machine further includes a traction module including at least a traction wheel engageable with elevator hoisting ropes, and a second transmission wheel, which are provided with a common rotational axis and connected coaxially to each other. The motor module and the traction module are positioned side by side with their rotational axes parallel, such that the traction wheel and the drive shaft are side by side, and the first and second transmission wheels are side by side. The drive machine further includes an endless drive member passing around the first and second transmission wheels. An elevator comprising said drive machine is also disclosed.
US10252882B2	Elevator motion alert system An elevator motion alert system is configured to alert a person of an object moving in at least one hoistway of an elevator system. The elevator motion alert system includes a sensor configured to detect object motion. A transmitter of the elevator motion alert system is carried by the object and is configured to transmit a pressure wave at a pre-defined frequency upon movement of the object. An electronic device of the elevator motion alert system is configured to receive and process the pressure wave for alerting the person of object movement.
US10252880B2	System and method of initiating elevator service by entering an elevator call In one aspect, a method for initiating elevator service by entering an elevator call on a call input device having a plurality of graphical objects displayed on a graphical user interface is provided. The method includes the steps of selecting a first landing graphical object from the plurality of graphical objects, and selecting a second landing graphical object from the plurality of graphical objects. The method also includes selecting a third landing graphical object from the plurality of graphical objects. The method also includes creating an anticipated trip graphical object, the anticipated trip graphical object indicating a trip from the third landing to the first landing. The method also includes selecting the anticipated trip graphical object to initiate a hall call and floor call from the third landing to the first landing.
US10252862B2	Picking station for picking articles into order containers and conveyor bags for order and batch picking A system and method for a picking station operation, provides switched flexibly between single-step- and dual-step-picking into various types of order containers. The task is solved by the provision of a second order container conveyor technique for transporting second order containers, in particular boxes, for receiving articles into order container bays, arranged also in the arrangement row, of the picking station.
US10252860B2	Modular sample storage system Various embodiments include a sample storage system having: a transport module; a storage module coupled with the transport module on at least one side of the transport module, the storage module for storing a plurality of specimen tubes or microtiter plates; a tube selector module coupled to an end of the transport module for selecting at least one of the plurality of specimen tubes or microtiter plates; and an input/output (I/O) module coupled with the transport module on a side of the transport module, wherein the transport module is configured to modularly couple with at least one additional storage module for storing a plurality of specimen tubes or microtiter plates.
US10252858B1	Caddy for cleaning supplies The present disclosure describes a caddy for cleaning supplies combining a storage tray, integrated chute and removable storage bin for holding dirty or contaminated items. The caddy generally has an upper section with a carrying handle for holding cleaning tools and a lower section used as a storage bin for dirty or contaminated items. In operation, the upper tray is removably fastened to the lower bin wherein the tray acts as a cover for the storage bin with the sidewalls of the storage tray positioned above the lower bin. Accordingly, the entire storage bin opening is covered by the tray when the upper section is fastened thereto. Additionally, a chute extends through the storage tray for depositing dirty or contaminated materials without unfastening the upper section from the lower section. Thus, unused or otherwise clean items are separated from dirty items while still being sufficiently held in a single caddy.
US10252855B1	Ramp wall for a container A ramp wall includes a load-bearing support structure having top, bottom and side edges. A first pivot assembly is connected with the support structure bottom edge and adapted for removable connection with at least one container wall. The first pivot assembly includes at least one counter balancing torsion spring that is connected with the bottom edge of the support structure. The spring has a torque force that is generally equal to the gravitational torque force generated by the weight of the ramp wall when it is connected with at least one container wall, allowing manual operation of the ramp wall between a vertical closed position and a horizontal or inclined open position. A second pivot assembly is connected with one of the support structure side edges and adapted for removable connection with a container side wall for swinging movement about a vertical axis between a vertical open position and a vertical closed position.
US10252854B2	Apparatus and products for producing beverages, and methods for making and using same A brewing container for use with brewing machines, the container including a distribution outlet for dispersing the injected water in at least 3 directions away from vertical within the cartridge.
US10252851B2	Evacuated bottle system An evacuated bottle system including a bottle defining a hollow interior, the bottle having a neck with a rim defining an opening; a cap assembly supported on the bottle, the cap assembly including a funnel having a first portion and a second portion, the first portion being insertable within the interior of the bottle and the second portion engaging a portion of the bottle to support the funnel above the rim, the funnel defining a bore that fluidly communicates with the hollow interior of the bottle; a self-sealing membrane that covers the bore formed by the funnel to selectively seal the hollow interior of the bottle; a cap attachable to the bottle, the cap including a cover portion that extends at least partially over the self-sealing membrane to restrain movement thereof, the cover portion being axially spaced from the self-sealing membrane to define a gap that permits axial movement of the self-sealing membrane to selectively open the bottle to fluid communication outside of the bottle.
US10252848B2	Self-standing barrel pouch A flexible pouch having a pair of spaced apart flaps is provided. The flexible pouch includes a pouch body having a generally cylindrical shape. The flaps are disposed along the longitudinal length of the pouch body as to help prevent the pouch body from rolling over when laid on its length. The pouch may further include a fitment and an intermediate portion having a ramp shaped portion. The ramp shaped portion is opposite the fitment and slanted so as to direct fluids towards the fitment.
US10252844B2	Tamper-evident closure A tamper-evident closure for a container. The closure comprises a first portion including inner and outer parts, and a second portion. The outer part is rotatable relative to the inner part from a first position in which at least part of the first and second portions are adjacent each other to a second position in which there is a gap therebetween. The first portion comprises a locking mechanism for irreversibly locking the closure in the second position upon first opening so that the gap cannot be closed, in which the first portion comprises a compressible stopper for sealing the second portion and/or the container. A tamper-evident closure in combination with a container.
US10252841B2	Dispensing closures and dispensers A dispensing closure for dispensing fluid product from a squeeze container consists of an outer cap element (3) and an inner element or valve disc (4) fitting inside the cap element. Each is molded from thermoplastics; no elastomer is used. The cap element includes an outwardly-deflectable diaphragm wall (35) around a central outlet opening (361). The inner element (4) has a peripheral mounting ring (41), a central blocking portion (48) and a set of support spokes (46) providing flow clearance between them. In a closed position the blocking portion closes the outlet opening. In an outflow condition the diaphragm wall (35) deflects outwardly to allow flow. In a recovery mode the blocking portion (48) deflects inwardly for compensation air or residual liquid product to enter the container.
US10252835B2	Attachment tags and methods of manufacture and use thereof A method for using an attachment tag with a product includes affixing an adhesive layer of the attachment tag to the product. The attachment tag includes an elastomer portion and a tag portion bonded to the elastomer portion along a bond zone, wherein the adhesive layer is disposed on the tag portion. The method also includes expanding the elastomer portion by at least partially separating at least two of a plurality of leg segments of the elastomer portion and securing the expanded elastomer portion around at least a portion of the product.
US10252818B2	Optical viewing apparatus for aircraft doorway A viewing device for an aircraft includes an image receiver adapted to receive an image of a predetermined spatial area of an exterior of an aircraft, an image projector adapted to display the image of the predetermined spatial area, and an image conduit connecting the image receiver to the image projector. The image receiver is adapted to be positioned on an exterior side of the aircraft below a lateral width of a fuselage of the aircraft while the image projector is adapted to be positioned on an interior side of the aircraft above the lateral width of the fuselage of the aircraft. The image projector is adapted to be positioned at a first predetermined height above a floor on the interior side of the aircraft, consistent with a person's eye level. The image projector is separated from the image receiver by a first predetermined distance.
US10252815B2	System and method for monitoring a cockpit of an aircraft A method of monitoring a cockpit of an aircraft includes receiving, by one or more controllers, an image depicting an operator manipulated input device located within the cockpit. The method can include determining, by the one or more controllers, an observed state of the operator manipulated input device. In particular, the observed state can be based on the image. The method can include determining, by the one or more controllers, a sensed state of the operator manipulated input device. In particular, the sensed state can be based on data from a sensor. The method can include determining, by the one or more controllers, a mismatch between the observed and sensed states of the operator manipulated input device.
US10252814B2	Automatic flight controller, aircraft cockpit, method for operating and automatic flight controller and computer program The invention concerns an automatic flight controller with operating elements, by means of which target settings of the automatic flight controller can be set by an operator, and with display elements for data display, wherein the display elements comprise at least two mutually separate displays that are disposed on the front, for example a front panel, of the automatic flight controller, wherein a) the at least two mutually separate displays are high resolution graphical displays and/or b) the automatic flight controller is designed to display all operating mode awareness-relevant parameters of the automatic flight controller on one or more of the at least two mutually separate displays of the automatic flight controller. The invention further concerns an aircraft cockpit with such an automatic flight controller as well as a method for operating a flight controller. The invention also concerns a computer program for carrying out the method.
US10252813B2	Method and a device for assisting the piloting of an aircraft, and an aircraft A method of assisting the piloting of an aircraft, such as a helicopter, includes determining a limiting power margin of a power plant of the aircraft relative to a power limit at an operating rating of an engine of the power plant. The limiting power margin is transformed into a collective pitch margin for the operating rating. The collective pitch margin represents the margin between a current collective pitch of blades of a main rotor of the aircraft and a collective pitch limit of the blades of the main rotor. The collective pitch limit is determined and then displayed on a display of the aircraft for a pilot to view.
US10252810B2	Propulsion engine for an aircraft A propulsion system for an aircraft is provided having a propulsion engine configured to be mounted to the aircraft. The propulsion engine includes an electric machine defining an electric machine tip speed during operation. The propulsion system additionally includes a fan rotatable about a central axis of the electric propulsion engine with the electric machine. The fan defines a fan pressure ratio, RFP, and includes a plurality of fan blades, each fan blade defining a fan blade tip speed. The electric propulsion engine defines a ratio of the fan blade tip speed to electric machine tip speed that is within twenty percent of the equation, 1.01×RFP−0.311, such that the propulsion engine may operate at a desired efficiency.
US10252809B2	Separating element for a platform cabin comprising a push rod mechanism for moving a leaf A separating element for a platform cabin is provided. The separating element comprises: at least one stationary partition, delimiting a passage defining a circulation axis inside the cabin; at least one leaf, mounted transversely movable relative to the circulation axis between a closed position, in which it extends through the passage, and an open position, in which it is positioned at least partially spaced away from the passage; and means for moving the or each leaf between the closed position and the open position thereof, the or each leaf being adapted to move along the plane transverse to the circulation axis.
US10252807B2	Runback control An ice protection system includes an aircraft surface and a gutter defined in the aircraft surface between raised rails. The gutter includes a mouth that narrows into a trailing portion of the gutter. The mouth is configured to channel water runback rivulets into the trailing portion of the gutter. The gutter can be a first gutter of a plurality of side by side gutters, each including a respective mouth narrowing into a respective trailing portion, wherein the gutters are separated from one another by respective rails.
US10252802B2	Flat panel loudspeaker system A flat panel speaker system is provided. The system includes, a modified panel having a front surface and a rear surface, wherein the modified panel acts as a diaphragm for the flat panel speaker system; a supporting member coupled to the rear surface of the modified panel; and a detachable driver operationally coupled to the supporting member.
US10252798B2	Vertical takeoff and landing airframe Airframes configured for stable in-flight transition between forward flight and vertical takeoff and landing are described herein. In one embodiment, an aircraft can include a fuselage, opposed wings extending from opposed sides of the fuselage, and a plurality of engines. At least one engine can be mounted to each of the opposed wings and at least a portion of each opposed wing including at least one of the plurality of engines can rotate relative to the fuselage around a rotation axis that is non-perpendicular and transverse to a longitudinal axis of the fuselage. Rotating portions of the wings including at least one of the plurality of engines in the described manner can provide a stable and smooth transition between vertical and forward flight.
US10252797B2	Tiltrotor propulsion system for an aircraft An aircraft includes a fuselage, a forward wing assembly, and aft wing assembly, and a propulsion system. The propulsion system includes a first primary thrust propulsor and a first secondary thrust propulsor, the first primary thrust propulsor being different than the first secondary thrust propulsor. Both the first primary thrust propulsor and the first secondary thrust propulsor are mounted to the same one of: a starboard side of the aft wing assembly, a port side of the aft wing assembly, a starboard side of the forward wing assembly, or a port side of the forward wing assembly.
US10252779B2	Unmanned vessel having coupling apparatus and recovery method therefor An unmanned vessel having a coupling apparatus includes: a heaving line launcher, which is provided on one side of the bow of the unmanned vessel; a coupling apparatus, which is provided at the center of gravity of the unmanned vessel and is coupled to a coupling member of a crane provided on a mother vessel; a first winch, which is provided on at least one side of either the bow or stern of the unmanned vessel, a first tow line being wounded around the same; and a second winch around which a second tow line, which passes one side of the coupling apparatus, is wound.
US10252773B2	Bicycle front derailleur A bicycle front derailleur is basically provided with a base member, a chain guide and a chain restricting abutment. The base member is configured to be mounted on a bicycle frame. The chain guide is configured to be movably coupled to the base member between a retracted position and an extended position to move a bicycle chain. The chain restricting abutment is configured to restrict the bicycle chain from moving in a radially outward direction of a rotational center axis of a bicycle front sprocket when the base member is mounted on the bicycle frame and the chain guide moves from the extended position toward the retracted position.
US10252770B2	Hub and disk brake system and apparatus A braking system includes a moveable structure connected to a rear brake. The rear brake may be a hub brake or a disc brake. A cable to the front brake is connected to the moveable structure. When the rear brake is actuated, the moveable structure moves. The movement of the structure pulls the cable to actuate the front brake. The movement may include a translation, rotation, or both.
US10252769B2	Bicycle apparatus A bicycle apparatus is basically provided with an ABS unit which is driven by an assist motor which adds an assisting force to a manual drive force inputted from a crankshaft of a bicycle, and which controls a braking force that is applied to a wheel of the bicycle.
US10252767B2	Outboard axle bearing structure for a bicycle or motorcycle In one example, a structure for attaching a wheel to one of a frame of a motorcycle or a bicycle may include an axle having first and second opposing end portions and supporting a wheel, a left axle support collar structure configured to support the first opposing end portion of the axle, and a right axle support collar structure configured to support the second opposing end portion of the axle. A first bearing is positioned in the left axle support collar structure, and a second bearing is positioned in the left axle support collar structure. The axle rotates relative to the frame.
US10252765B2	Handle attachment and handle of time trial bike A handle attachment of the present invention is attached to a bullhorn handle of a time trial bike equipped with downhill bars, armrests and bullhorn handles. The handle attachment includes a locking part attached to the vicinity of the tip end of the bullhorn handle. Moreover, the locking part has a wall surface portion protruding outward from the surface of the bullhorn handle and forming a wall surface.
US10252755B2	Aerodynamic system and adjustable fairings Embodiments provide an aerodynamic fairing system that may comprise a base configured to mount to a vehicle, an arm coupled to the base at a proximate end and extending laterally, an a fairing mounted to the arm having an inboard and an outboard surface. The fairing outboard surface may provide an aerodynamic outer surface to direct flow to an angle to the rear. The arm may a fixed or adjustable length arm. The arm may provide a mounting area for a mud flap such that aerodynamic system may act as a mud flap hanger. Embodiments also provide an adjustable mud flap hanger.
US10252754B2	Method for reinforcing a subframe The present invention relates to a method for reinforcing a vehicle subframe comprising one or more hollow sheet metal parts, comprising: determining at least one area on a hollow sheet metal part of a subframe with respect to specified conditions; preparing a reinforcement part which is insertable into the hollow sheet metal part at the determined area, wherein the reinforcement part comprises: a carrier having at least one hollow chamber; and a pre-foam of a foam material, which is able to expand after being heated, the pre-foam being isolated from the at least one hollow chamber and distributed at least partly on the periphery of the carrier; and installing the reinforcement part within the hollow sheet metal part at the determined area and heating the pre-foam such that it expands. The present invention also relates to a vehicle subframe reinforced by said method.
US10252750B2	Vehicular frame Provided is a front side frame 2, comprising: a main frame 201; and reinforcing members 30, 40, 50 disposed inside the main frame 2, wherein the reinforcing member 30 includes partition wall portions 31b, 32d, 32e dividing a main closed cross-section C_m of the main frame 201 into a plurality of sub closed-cross sections c, the first to third partition wall portions 31b, 32d, 32e being respectively formed with compression-side ridges 31s, 32s, 32u vertically facing each other and able to come into contact with each other in a deformation of the front side frame 2, and tension-side ridges 31t, 32t, 32v arranged in the same manner.
US10252749B2	Spindle system for wheel alignment correction A spindle sleeve and washer for adjusting the camber, toe, or thrust angle of a vehicle wheel to a desired predetermined angle which allows for use of existing hub and spindle assembly without permanent modification to the vehicle.
US10252745B2	Motor control apparatus, electric power steering apparatus, and vehicle There are provided a motor control apparatus, an electric power steering apparatus, and a vehicle, capable of controlling the driving of an electric motor accurately even when a failure occurs in a motor electric angle detecting unit that detects a motor electric angle. The motor control apparatus includes: a relative offset amount estimating unit that estimates a relative offset amount between a reference value of an output shaft rotational angle detection value of a steering shaft, detected by an output-side rotational angle sensor, and a motor electric angle original point of a three-phase electric motor; and a motor electric angle estimating unit that calculates a motor electric angle estimate (θme) based on the output shaft rotational angle and the relative offset amount, wherein when at least either one of a resolver and an angle computing unit is abnormal, the driving of the three-phase electric motor is controlled based on the motor electric angle estimate estimated by the motor electric angle estimating unit.
US10252743B2	Electric power steering device An electric power steering device is provided, easing a sense of incongruity that a driver feels with respect to steering. If an abnormal phase is detected, an electronic control unit (ECU) 50 stops energizing a winding (any one of windings 86u, 86v and 86w) of the abnormal phase and energizes windings (two of the windings 86u, 86v and 86w) of the two phases other than the abnormal phase, and, as a vehicle speed V increases, the ECU 50 reduces a current value applied to the windings (two of the windings 86u, 86v and 86w) of the two phases other than the abnormal phase.
US10252741B2	Electrostatic steering wheel hold detection device An electrostatic steering wheel hold detection device includes: a first heater element located in a steering wheel, and has one end electrically connected to a power source; an inductor—that is electrically connected to an other end of the first heater element; a second heater element that is included in the steering wheel, and has one end electrically connected to the other end of the first heater element via the inductor; and a sensor circuit that is electrically connected to a connection point between the first heater element and the inductor, and detects, from a change in capacitance at the connection point, whether or not the steering wheel is held. An other end of the second heater element is electrically connected to a ground. The second heater element is located lower than the first heater element in the steering wheel when the steering wheel is in a neutral position.
US10252737B2	Shelf for a trolley A shelf for a trolley comprising a plate providing a surface for carrying goods, such as potted plants and flowers, and hooks for mounting the shelf in the trolley. One or more of the hooks are formed from a metal strip bent about an axis extending perpendicular to the central plane of the plate.
US10252729B1	Driver alert systems and methods Systems and method are provided for issuing a driver alert. In one embodiment, a method includes: receiving, via a processor, driving parameter data representing a current driving parameter for a driving vehicle, receiving, via the processor, threshold data representing driving thresholds for the at least one driving parameter, determining, via the processor, whether to issue a driver alert based on the threshold data and the driving parameter data, thereby producing alert data, and generating and outputting an in-vehicle driver alert based on the alert data.
US10252726B2	Driving assistance method, and driving assistance device, driving control device, vehicle, driving assistance program, and recording medium using said method The driving assistance device acquires, from an autonomous driving controller that determines an action of a vehicle during autonomous driving of the vehicle, action information indicating a first action that the vehicle is caused to execute. The driving assistance device acquires, from a detector that detects a surrounding situation and a travel state of the vehicle, detection information indicating a detection result. The driving assistance device determines a second action which is executable in place of the first action, based on the detection information. The driving assistance device generates a first image representing the first action and a second image representing the second action. The driving assistance device outputs the first image and the second image to a notification device such that the first image and the second image are displayed within a fixed field of view of a driver of the vehicle.
US10252723B2	Slip factor learning method of dual clutch transmission A slip factor learning method of a dual clutch transmission (DCT) may include: determining, by a control unit, whether the DCT is up-shifted or down-shifted; comparing an engine speed to a shift start reference speed, and determining whether the engine speed enters an actual gear shifting period or actual gear shifting is completed, in response to the determined type of the gear shifting; comparing a magnitude of an engine torque to a magnitude of a clutch torque at a point of time that the engine speed enters the actual gear shifting period or the actual gear shifting is completed; and learning a slip factor at the point of time that the engine speed enters the actual gear shifting period or the actual gear shifting is completed, based on the magnitude comparison result between the engine torque and the clutch torque.
US10252722B2	Method for controlling manual driving mode of autonomous vehicle A method for controlling a manual driving mode includes manual mode detecting step detecting whether a vehicle switched from autonomous to manual mode; first step controlling angle of tire and steering angle of a steering wheel using travel route information when switching to manual mode is detected; delay time determination step determining a delay time of change of the angle of the tire with change of the steering angle of the steering wheel by the change in the angle of the tire with the change in the steering angle of the steering wheel for predetermined time; delay time comparison step comparing the determined delay time with predetermined time period; second step controlling only the steering angle of the steering wheel using travel route information when delay time is within the predetermined time period; and third step controlling angle of the tire by steering angle of the steering wheel.
US10252719B2	Control device for continuously variable transmission A control device for a continuously variable transmission includes a lock-up clutch of a torque converter which is arranged to connect and disconnect a power transmission between a power source and the driving wheel, and a control section configured to output a hydraulic pressure command value. The control section is configured to control a transmission gear ratio of the continuously variable transmission and an engagement state of the lock-up clutch in accordance with a traveling state of a vehicle. The control device includes a learning control section configured to perform a learning control of the engagement state of the lock-up clutch with respect to the hydraulic pressure command value, an oil vibration sensing section configured to sense oil vibration of a line pressure, and a learning control prohibiting section configured to prohibit the learning control when the oil vibration sensing section senses the oil vibration.
US10252717B2	Vehicular mitigation system based on wireless vehicle data The disclosure includes embodiments for modifying the acceleration of an ego vehicle based on wireless vehicle data included in a wireless message. A method includes receiving the wireless message that includes wireless vehicle data that describes one or more physical properties of a downstream vehicle. The wireless vehicle data indicates a presence of a traffic obstruction. The method includes determining a modification for an acceleration of the ego vehicle based on the wireless vehicle data and the indication of the traffic obstruction. The method includes modifying the acceleration of the ego vehicle based on wireless vehicle data compliant with the DSRC standard. The modified acceleration causes the ego vehicle to travel at a velocity consistent with a preceding vehicle and the downstream vehicle so that the ego vehicle does not collide with the preceding vehicle or the other downstream vehicle, which are in the same lane as the ego vehicle.
US10252716B2	Driving assist apparatus and driving assist method A driving assist apparatus activates a safety device for avoiding a collision of an own vehicle with a target or reducing damage from the collision. The driving assist apparatus determines start of a collision avoidance operation for the target. The driving assist apparatus performs a delaying process for delaying an activation timing of the safety device, when the start of the collision avoidance operation is determined, the delaying process setting the activation timing to a timing later than a timing that would be set when the start of the collision avoidance operation is not determined. The driving assist apparatus determines, based on the activation timing, whether to activate the safety device. The driving assist apparatus continuously performs the delaying process until a predetermined time period elapses after the start of the collision avoidance operation.
US10252708B2	Remote startup control device and method in consideration of operational state of parking brake A remote startup control device and method in consideration of an operational state of a parking brake is disclosed. The remote startup control device includes an air processing device for supplying compressed air to a parking brake chamber, a relay valve for controlling an air line connecting the air processing device to the parking brake chamber, and a control unit for determining whether to permit remote startup based on whether an input switch and an output switch of the relay valve are in an activated state.
US10252706B2	Master cylinder for vehicle A master cylinder includes: a cylinder housing; a piston which is movably disposed in the cylinder housing so as to form a pressure chamber and a hydraulic fluid supplying chamber; and a sealing member which is interposed between the cylinder housing and the piston. An indentation portion is provided on an outer circumferential surface of the piston, wherein a rear wall of the indentation portion is formed as a slanted surface. A plurality of first communication holes are formed on a bottom surface of the indentation portion and a second communication hole is formed on the rear wall of the indentation portion.
US10252704B2	Vehicle reverse assistant A vehicle reverse assistant includes a rear side sensor, a towed object detector, and a stop determination threshold distance setter. The rear side sensor is provided at a rear portion of an own vehicle. The rear side sensor senses a rear side sensing region. The towed object detector detects whether a towed object is connected to the rear portion of the own vehicle. The stop determination threshold distance setter sets one end of a stop determination threshold distance at a position spaced apart at a constant distance from a rear end of the towed object on a basis of a sensing signal supplied from the rear side sensor when the towed object detector detects connection of the towed object.
US10252703B2	System for cleaning on-vehicle optical sensor and method for the same The on-vehicle optical sensor cleaning system includes a washer pump that feeds a cleaning liquid, an air pump, a nozzle member, and a controller. The air pump includes a discharge valve and discharges air through the discharge valve. The discharge valve opens when air is compressed in the air pump. The nozzle member includes an ejection port that ejects a gas-liquid mixture toward a sensing surface of an on-vehicle optical sensor to remove foreign matter from the sensing surface. The cleaning liquid from the washer pump and the air from the air pump are mixed in the gas-liquid mixture. The controller controls the washer pump and the air pump. The controller is configured so that the gas-liquid mixture is ejected by storing the cleaning liquid in the nozzle member to cover the ejection port and then feeding the air to the nozzle member.
US10252699B2	Method for operating a passive radio-based locking device and passive radio-based locking device with a mobile device as a transportation vehicle key A method for operating a passive radio-based locking apparatus of a transportation vehicle wherein the locking apparatus enables at least one access function of the transportation vehicle, wherein the passive radio-based locking apparatus includes a mobile device embodied as a radio key unit and a transceiver at the transportation vehicle, between which at least two electromagnetic radio signals are exchanged for the electromagnetic radio connection, and for the operation, one parameter of each of the radio connections of the passive radio-based locking apparatus is modified. Prior to enabling the access function, an identification feature of at least two data communication interfaces for setting up communication for the radio connections at the radio key unit and/or at the transceiver is modified and also each is set to a latest value, and the access function is enabled only in response to the relevant identification feature having the latest value.
US10252697B2	Systems and methods for estimating torque in a locked vehicle system A system for estimating torque in a locked vehicle system may include a locking mechanism comprising a stiff material. The system may further include a controller configured to estimate an amount of torque in the locked vehicle system based on a deformation of the stiff material.
US10252689B2	Knee airbag with receiving pockets A knee airbag includes a front panel, a rear panel and first and second tethers. The first tether is between the panels and defines an outboard chamber. The second tether is between the panels and defines an inboard chamber. The tethers cooperatively define a center chamber. The chambers, in an inflated position, are substantially vertical and parallel. The inboard chamber is thinner than the other chambers. In the inflated position, the tethers respectively define first and second knee-receiving pockets.
US10252687B1	Vehicle side impact detection A vehicle includes an instrument panel, a pressure sensor, and a door. The instrument panel defines a sensor cavity and a first opening in fluid communication with the sensor cavity. The pressure sensor is in the sensor cavity. The door defines a door cavity and a second opening in fluid communication with the door cavity. The door is moveable between an open position and a closed position. The first and second openings are engaged with each other in the closed position and disengaged with each other in the open position.
US10252682B2	Method and apparatus for securing alignment measurement components to large diameter wheels A set of light-weight adaptor assemblies suitable for use with optical targets, angle sensors, or other instrumentation. A first configuration of adapter assembly within the set is easily secured against the outboard surfaces a large-diameter vehicle wheel assembly having a highly convex raised central hub region, without concern for precise axial alignment or centering, while a second configuration of adapter assembly within the set is easily secured against the outboard surfaces of a large-diameter vehicle wheel assembly having a highly concave recessed central hub region, without concern for precise axial alignment or centering.
US10252680B2	Articulating cargo management and rack system In one aspect the present disclosure relates to a cargo management system for use in a cargo area of a vehicle. The system may use a track secured to a wall of the cargo area. An articulating system is secured to the track and adjustably positionable at a plurality of positions along the track. The articulating system includes a mounting panel adapted to be secured to the track, at least a first frame section, and a first articulating hinge system for supporting the first frame section for movement on the mounting plate. The first articulating hinge system has a first actuating element normally held in a locked orientation to hold the first frame section stationary, and movable into an unlocked position by a rotational force applied by a user, to enable the first articulating hinge system to be rotated on the mounting plate into a new orientation, and then held in the new orientation when the first actuating element is released by the user.
US10252679B2	Skeleton for truck bed and convertible top A truck bed accessory frame is disclosed therein which allows for reconfiguration between an opened position and a closed position. In the open position, objects taller than the frame can loaded onto the truck bed. In the closed position, objects placed in the truck bed can be protected from the environmental elements (e.g. rain and UV rays from the sun).
US10252677B2	Footwear and accessory retention pouch for use in vehicles A footwear and accessory retention pouch serves to segregate and retain footwear and accessories in an organized, accessible manner in a vehicle. The pouch is specially adapted for suspension between the seatbacks of a vehicle having individual or split seats. The pouch comprises a container defined by container sidewalls that form an opening at one end, and at least one interior barrier that segregates the container into chambers that receive footwear. A depressed cap covers the opening in the container. The depressed cap comprises cap sidewalls and a cap platform for retaining an accessory while the cap is covering the opening in container. A rechargeable recharging device operatively connects to the depressed cap for charging a communication device. A plurality of straps and a central adjustable cable are length adjustable and extend from the sidewalls of the container for fastening container between, behind, or in front of the vehicle seats.
US10252674B2	Blind spot detection module Provided is a blind spot detection module, including: a light source module linked with a sensor signal for detection of an object in an area behind a vehicle to emit light; and a reflector module including a warning optical pattern for transmitting light emitted from the light source module, wherein the light source module comprises a light guide member adopted to receive a light emitting element and to guide light to the reflector module.
US10252671B2	Motor vehicle having a rear view device with no wing mirrors A motor vehicle having a rear view device with no wing mirrors is disclosed. The rear view device includes at least one camera, by which at least one part of a rear space/traffic situation can be recorded, and at least one screen, on which the image section recorded by the at least one camera can be displayed. The at least one screen is arranged on a console of a side door protruding towards the vehicle interior, where this console engages at least partially with a recess of the dashboard when the side door is closed.
US10252664B2	Vehicle wheel-based power generation and display systems A power generation system is provided configured for installation within a wheel of a vehicle. The system includes a stator having a plurality of face-mounted permanent magnets; and a rotor having a plurality of windings configured to rotate, with rotation of the wheel, in proximity to the permanent magnets thereby generating a current. The stator is mounted to a brake caliper of the vehicle. Also provided is a wheel-based vehicle display system including a light emitting diode (LED) array arranged on or within a wheel of a vehicle; a power source connected thereto; and a controller connected to the LED array. The display system is configured to display at least one of: textual information, visual images or full-motion video.
US10252657B2	Headrest with adjustable side elements A headrest for a seat of a vehicle includes a body securable to the seat, a side portion adjacent the body, a receiver pivotally attached to the body, a slide attached to the side portion so as to be movable along the receiver between a first position in which the side portion is in a retracted position and a second position in which the side portion is in an extended position, and a friction member on one of the receiver and the slide. A securing mechanism causes the friction member to hold the slide in a selected position relative to the receiver.
US10252656B2	Cover feed-through for a head-restraint rod of a head restraint A cover feed-through (B), for a head-restraint rod (5) of a head restraint for a vehicle seat, is configured as a one-piece self-securing guide element (1). The guide element has a closed upper face (2) and a lower face (4) which is spaced from the upper face by a passage (3). The lower face (4) has at least one opening (4.1) substantially in the form of a segment of a circle. A vehicle seat is also provided, including a cover (8) and a head-restraint which can be arranged in a cover feed-through (B).
US10252652B2	Seating assembly with heating and cooling A vehicle seating assembly includes a seating surface, a fluid mover, and a fluid transfer member. The fluid transfer member includes a tube. The tube includes an inlet and an outlet. The inlet is fluidly coupled to the fluid mover, and the outlet is coupled to a holder that includes a resistive heater. The fluid mover and the resistive heater are selectively operable to convectively cool or heat the seating surface.
US10252651B2	Seat assemblies having seat heater wire harnesses connected to child restraint brackets for vehicles A seat assembly includes a seatback, a seatback heater, a child restraint bracket, and a wire harness. The seatback is moveable between a seated position and a folded position. The seatback heater is connected to the seatback. The child restraint bracket includes a pair of isofix anchors. The wire harness includes a first end and an opposite second end. The first end is connected to the child restraint bracket. The second end is connected to the seatback heater. The wire harness accommodates movement of the seatback between the seated position and the folded position.
US10252646B2	Child safety seat adjustable between multiple angular positions A child safety seat includes a seat shell, an extension member connected with the seat shell, and a front and a rear foot respectively connected with the seat shell and movably linked to the extension member. The seat shell has a bottom surface capable of resting on a vehicle seat. The extension member is movable between a first position where a forward end of the extension member extends forward from the front end of the seat shell, and a second position where the extension member is retracted toward the seat shell. The front foot and the rear foot are movable relative to the seat shell to adjust the seat shell between a first and a second angular position, the seat shell being in the first and second angular position when the extension member is respectively in the first and second position.
US10252645B1	Ventilated child car seat The ventilated child car seat is a child safety seat with internal ductwork and vents. An external intake hose attaches to a vehicle air vent and directs the air from the vehicle environmental control system to the child seat. The internal ductwork and vents allow the heated or chilled air to circulate around the occupant of the child safety seat. Movable vent covers on the child safety seat allow the flow of air to be reduced or stopped.
US10252644B2	Tip and slide system for a vehicle seat A vehicle seat includes a seatback pivot, a rear-access lever that rotates an overslide cam and a pawl of the seatback pivot. Operation of the rear-access lever with the seatback pivot in a first radial range defines selective rotation of the overslide cam by the pawl. Operation of the rear-access lever with the seatback pivot in a second radial range defines a deflection of the pawl by the overslide cam.
US10252642B2	Input device having an operation knob An input device has operation shafts whose tips project through a first elongate hole and a second elongate hole formed through an upper plate portion of a case main body and that are movable along the upper plate portion of the case main body. An operation knob is movably attached to the tips of the operation shafts. The case main body is provided with elastic support pieces that deform following the movement of the operation knob and elastically support the operation knob.
US10252637B2	Saddle-ride vehicle A saddle-ride type vehicle includes a vehicle body frame steerably supporting a front fork by a head pipe and swingably supporting a rear wheel unit around a pivot, an air-cooled type fuel cell unit supported by the vehicle body frame on a rear side of the head pipe and including an outside air intake port facing forward, and a vehicle body cover defining a front of an intake air space that is connected to the intake port. The vehicle body cover includes a traveling air passage changing a direction of traveling air that flows in from a front. Accordingly, it is possible to efficiently supply traveling air to a fuel cell unit that includes a fuel cell.
US10252634B2	Power supply apparatus A power supply apparatus and method for providing electric energy to a target system are provided. The power supply apparatus includes: a capacitor module configured to store electric charge and provide electric energy to a target system based on the stored electric charge; an internal battery module configured to be operably connected with the capacitor module in series; and an output interface configured to couple the internal battery module with the capacitor module. The internal battery module and the capacitor module provide electric energy to the target system in controllable series connection through the output interface.
US10252633B2	Managing electric current allocation between charging equipment for charging electric vehicles A first and second charging equipment for charging electric vehicles share a current capacity. A controller coupled with the first and second charging equipment limits a total amount of current drawn through the first charging equipment and the second charging equipment to not exceed the current capacity. A first and second current limit is communicated to a first and second electric vehicle respectively to limit the current draw of first and second electric vehicle to the first and second current limit respectively. A sum of the current drawn at the first and second current limit does not exceed the current capacity.
US10252627B2	On board charger input current limit setting based on AC input circuit voltage response This disclosure relates to the field of electric vehicles (EV) that run, at least in part, on an electric motor. Included on the EV is an on board charger (OBC) responsible for charging a battery supply based on electronic power received from a source. The OBC is configured to detect certain voltage or current characteristics during a charging operation of the battery supply, and adjust allowed operational limits for the OBC accordingly.
US10252626B2	Charger A charger with a power converting inverter that can be reliably stopped by a forced stop signal, without causing an increase in part quantity. A control power supply supplies voltage to gate drive circuits, which supply gate signals to an inverter. The control power supply includes a transformer, a power supply control circuit IC that repeatedly opens and closes a primary side circuit formed by a primary winding of the transformer and an auxiliary machine power supply being connected in series, and a rectifier that generates power supply voltage to be supplied to the gate drive circuits by rectifying AC voltage generated in a secondary winding of the transformer. The power supply control IC turns off a FET in accordance with a forced stop signal, thereby forcibly switching the primary side circuit to an open state, and stopping the supply of power supply voltage to the gate drive circuits.
US10252623B2	Charge/discharge system A charge/discharge system includes first and second electric chargers that supplies electric power to a motor generator and charges electric power generated by the motor generator, an electric power converter that complementarily performs charging/discharging between the first and second electric chargers, and a controller. The controller controls the electric power converter based on charging conditions of the first and second electric chargers such that electric power charged in the first electric charger is charged in the second electric charger, or electric power charged in the second electric charger is charged in the first electric charger.
US10252622B2	Low charge acceptance mitigation A vehicle may include a battery and a controller programmed to set a bus voltage threshold such that during a next charging event a voltage of the battery achieves a desulfation value. The controller may set the bus voltage threshold in response to charge acceptance of the battery falling below a predetermined sulfation value. The controller may be programmed to lower the threshold such that the voltage of the battery falls below the desulfation value. The controller may lower the threshold in response to the charge acceptance exceeding the predetermined sulfation value during the event.
US10252618B2	Backup electrical supply for main capacitor discharge A vehicle may include an electric drive system including switches having gates configured to control the switches. The vehicle may include a galvanic isolation coupling having a primary side electrically connected with an input power source and a secondary side electrically connected with a gate driver circuit. The gat driver circuit has a controller configured to actuate the gates and a power supply circuit electrically connected to the controller to provide backup power. The galvanic isolation coupling may be a flyback converter.
US10252613B2	Dual clutch transaxle A dual clutch transaxle is provided that includes a dual clutch assembly, an input shaft assembly, a counter shaft assembly, a shift assembly and at least one output assembly. The dual clutch assembly has a dual clutch axis and includes a first clutch shaft and a second clutch shaft. The input shaft assembly includes a nested first inner input shaft and a second outer input shaft that are operationally coupled to the first clutch shaft and a second clutch shaft. An input shaft axis is offset from the dual clutch axis of the dual clutch assembly. A plurality of drive gears of the input shaft assembly are operationally coupled to a plurality of driven gears of the counter shaft assembly. The shift assembly is operationally coupled to select. The at least one output assembly is operationally coupled to the counter shaft assembly.
US10252609B2	Hybrid axle assembly for a motor vehicle An axle assembly for an electric or hybrid vehicle includes electrically powered drive motors for respectively driving vehicle wheels. The axle assembly preferably includes a dual motor arrangement, wherein two electric motors are arranged end-to-end. Each motor includes an inverter that is directly connected to its respective motor, and includes a gearbox assembly coupled between an output of the motor and a corresponding constant-velocity (CV) joint operatively connected to a wheel. The inboard ends of the motors are secured to opposite faces of a cooling manifold wherein the cooling manifold maintains the motors in axial alignment. The cooling manifold plate is positioned between an inboard end of each of the motor housings, and the cooling manifold plate axially aligns the first and second motors. Further, each motor drives its respective gearbox assembly, which includes a gear reduction and clutch mechanism having a brake band assembly that is selectively operable to disconnect the respective motor from the vehicle wheel associated therewith.
US10252603B2	Truck cap with rear lift gate for a truck A rear lift gate can be hingedly coupled to a truck cap body and movable between a lowered closed position and a raised open position. The rear lift gate can include a lower margin having a convex shape generally corresponding to an outward or rearward convex upper margin of the tailgate. The rear lift gate can further include a seal strip mounted to an interior side of the lower margin of the rear lift gate. The convex lower margin of the rear lift gate can overlay the convex upper margin of the exterior side of the tailgate with the seal strip of the interior side of the lower margin of the rear lift gate sealing against the exterior side of the convex upper margin of the tailgate when the rear lift gate is in the lowered closed position.
US10252600B2	Air-conditioning apparatus for vehicle There is disclosed an air-conditioning apparatus for vehicle which is capable of selecting an appropriate operation mode while inhibiting the operation mode from being unnecessarily changed, and achieving rapid and stable vehicle interior air conditioning. A controller has respective operation modes of a heating mode, a dehumidifying and heating mode, a dehumidifying and cooling mode, and a cooling mode, and selects and executes these operation modes. The controller has a dehumidifying and heating mode maximum radiator temperature MAP and a dehumidifying and cooling mode maximum radiator temperature MAP. The controller selects an operation mode in which a radiator target temperature TCO is achievable by heat radiation in a radiator 4 with reference to each MAP, on startup or at a time of change of the operation mode.
US10252591B1	Method and apparatus for electric tongue jack An improved electric tongue jack with one or more memory buttons to retract or extend to a predetermined desired height. A first memory button is provided to engage in a memorizing operation to store a desired actual height of the hitch. When the first memory button is subsequently engaged, the motor gear assembly is controlled to return the hitch to the desired height. A second memory button is used as an automatic retraction for the jack leg once the trailer has been set on the hitch ball/tow vehicle. Once the auto retract location has been set, the user may push the auto retract button once and the leg will automatically retract to the preset height. The memory buttons are controlled by software in a printed circuit board inside the head of the jack.
US10252589B2	Trailer coupling having an evaluation device, evaluation device and evaluation method A trailer coupling for a towing vehicle, having a coupling carrier, which includes, in particular, a coupling arm and at whose free end a coupling body, in particular, a coupling ball is arranged for connecting a trailer, and which coupling carrier is fixedly or movably arranged on a mount which is or can be attached to the towing vehicle, and having a sensor arrangement which has at least one sensor and has the purpose of sensing a traction force and/or thrust force which can be caused by a traction load acting on the coupling element during a traction operation of the trailer and of outputting a force signal representing the traction force and/or thrust force, and having an evaluation device for determining a trailer mass value of the trailer on the basis of the force signal.
US10252588B2	Trailer hitch system A trailer hitch system for improving the speed and safety of attaching the trailer to a tow vehicle. The hitch may include a shank that may be attached to the trailer through a ball hitch. A receiver may be provided on the tow vehicle such that attachment of the trailer to the tow vehicle may be accomplished by introducing the shank into the receiver when the tow vehicle is backed to the trailer. A funnel shaped guide member may be provided to facilitate aligning the shank with the receiver. Also, friction reducing rollers may be used with the shank or the receiver. Moreover, a height adjustment and visual guidance system may be included to facilitate connecting the trailer to the tow vehicle.
US10252584B2	Tire fill assist method and apparatus A tire condition monitoring apparatus includes a tire-based sensor configured to sense tire operating conditions and transmit a tire condition signal including the sensed tire operating conditions. The apparatus also includes a vehicle-based controller configured to receive the tire condition signal and monitor the tire operating conditions. At least one of the sensor and the controller are configured to determine that a tire pressure adjustment condition exists in response to determining, based on the sensed operating conditions, that a predetermined change in the number of moles of air in the tire has taken place.
US10252580B2	Tread wear indicator A tread wear indicator for a tire is provided. The tire includes a pair of sidewalls and a tread, and the tread includes a plurality of tread elements defined by circumferential grooves and lateral grooves. The tread wear indicator is formed in a selected one of the tread elements. The indicator includes a plurality of concentric step elements that descend radially inwardly from a radially outward surface of the selected one of the tread elements. Each step element includes an axially-extending surface that is approximately parallel to and is radially inward of the radially outward surface of the selected one of the tread elements, and a radially-extending surface that extends approximately perpendicular to the axially-extending surface.
US10252577B2	Pneumatic tire A tread pattern on a pneumatic tire is provided in regions of two intermediate land portions and has circumferential shallow grooves extending in the tire circumferential direction. An orientation of a groove inclination inclined with respect to a first direction in the tire circumferential direction of lug grooves provided in a region of one intermediate land portion, is the same as an orientation of a groove inclination inclined with respect to a second direction opposite to of the first direction of the tire circumferential direction of lug grooves provided in a region of another intermediate land portion, and the lug grooves provided in the respective regions of the intermediate land portions are bent so that the groove inclination approaches the tire circumferential direction at positions of intersection with the circumferential shallow grooves.
US10252574B2	Pneumatic tire having a jointless band ply and method for manufacturing same To increase a restraining force to a belt layer and to improve the durability of the tire. A band layer of a spirally wound band-like ply includes: a first ply portion extending from a starting end located between the tire equator and one end in the tire axial direction of a belt layer to the one end in the tire axial direction of the belt layer; a second ply portion extending from the one end in the tire axial direction of the first ply portion to the other end in the tire axial direction of the belt layer; and a third ply portion extending from the other end in the tire axial direction of the second ply portion to a terminal end located between the tire equator and the other end in the tire axial direction of the second ply portion. The band-like ply is continuous from the starting end to the terminal end without interruption.
US10252570B2	Bicycle rim A bicycle rim basically includes a first annular side surface portion, a second annular side surface portion, an annular connecting portion and an outermost layer. The first annular side surface portion includes a first braking surface. The second annular side surface portion includes a second braking surface. The epoxy resin layer is an example of a nonmetallic layer. The annular connecting portion connects the first and second annular side surface portions. The soft additive granules are disposed in at least one of the first and second annular side surface portions. The epoxy resin layer is disposed in at least one of the first and second annular side surface portions. The soft additive granules are at least partially embedded in the epoxy resin layer. The outermost layer covers the epoxy resin layer and the soft additive granules.
US10252569B2	Motor vehicle wheel A wheel for a motor vehicle having a wheel rim connected to a wheel flange via wheel spokes. At least one wheel spoke having a higher mass than at least one of the remaining wheel spokes. The higher mass of the at least one wheel spoke partially compensated for by the lower mass of the at least one remaining wheel spoke.
US10252560B2	Image forming apparatus and image forming method In an image forming apparatus, an extraction processing portion extracts one or more items of personal information from image data of a card read by an image reading portion. A document data acquiring portion acquires image data of a fixed-form document. A document layout acquiring portion acquires document layout information that indicates one or more composite positions in the image data of the fixed-form document where the one or more items of personal information are to be combined. A composition processing portion generates composite image data by combining the personal information extracted by the extraction processing portion with the image data of the fixed-form document in accordance with the document layout information. A print control portion causes an image forming portion to execute a composite image printing process of printing a composite image represented by the composite image data on a sheet.
US10252556B2	Selective overcoat Examples described herein include examples methods for generating varnish knockouts that include applying a fixer material to a surface of a print medium, selectively applying a print material over the fixer material to form an image, and applying an overcoat material to form a durable coating on areas over the image and a nondurable coating over other areas of the surface.
US10252544B2	Apparatus and method for depositing a substance on articles Apparatuses and methods for depositing a substance onto an article are disclosed, including apparatuses and methods of directly printing on three-dimensional articles, as well as the articles printed thereby or having a substance deposited thereon. In some cases, the apparatuses and methods involve creating a re-circulating relative motion between at least one article and a substance deposition device. In some embodiments, the articles can be conveyed in a closed loop path past one or more substance deposition devices. The articles can be conveyed past the substance deposition device(s) one or more times, and during each pass by the substance deposition device(s), a portion of a predetermined pattern may be applied to the articles by the substance deposition device(s).
US10252540B2	Ink delivery system for supplying ink to multiple printheads at constant pressure An ink delivery system for an inkjet printer includes: a positive ink line; a negative ink line; and one or more print modules interconnected between the positive ink line and the negative ink line. Each print module includes: an inlet port; an outlet port; a printhead interconnected between the inlet port and the outlet port; a control valve positioned at the inlet port for controlling an ink pressure in the printhead; an ink pressure sensor for sensing an ink pressure in the print module; and a controller for receiving feedback from the pressure sensor and controlling the control valve. During printing, the ink pressure sensor, the controller and the control valve cooperate to control a backpressure in the printhead within a predetermined backpressure range.
US10252539B2	Fluid ejection apparatus In a fluid ejection apparatus, fluid flows from a tank, through a fluid inlet, to a fluid supply passage which extends to nozzles. A driver is configured to apply energy to fluid in the fluid supply passage to eject fluid from the nozzles. A purge unit is configured to purge fluid from the nozzles to execute first purging. A controller is configured to receive, from a user input unit, a refill completion signal indicating that the tank is refilled with fluid, obtain an amount of fluid consumed since receipt of the refill completion signal by counting an amount of fluid discharged from the nozzles, and determine an amount of fluid to be purged by the first purging by subtracting the amount of fluid consumed from a total capacity of the fluid supply passage.
US10252535B2	Ink tank and inkjet printer A sub tank (40) which is mounted in an inkjet printer including an inkjet head for discharging UV ink and supplies UV ink to the inkjet head includes a space forming unit (41) which forms a space (40a) including an ink storage chamber (40b) for storing UV ink and a pump communication port communicating with a pump for making a pressure in the space (40a) negative, and a liquid-proof ventilation filter (44) which is disposed in the space (40a), allows gas to be circulated, and does not allow the UV ink to be circulated so as to prevent the UV ink from flowing out from the space (40a) to the pump communication port.
US10252533B2	Printing apparatus A printing apparatus includes: a platen having a supporting surface configured to support a recording medium; a liquid droplet jetting head having a nozzle surface on which nozzles are open; a head moving unit configured to move the liquid droplet jetting head in a head movement area including a first area and a second area which is adjacent to the first area; a maintenance mechanism including a cap member configured to be movable in a cap movement area which includes a retracted position and a capping position and to cover the nozzles; a cap moving mechanism configured to move the cap member by utilizing movement of the liquid droplet jetting head form the first area to the second area; and a cap guiding mechanism configured to guide movement of the cap member in the cap movement area in an inclined direction.
US10252525B2	Lead-free piezo printhead using thinned bulk material An apparatus for a lead-free piezoelectric ink-jet printhead is disclosed. Piezoelectric printheads, while more expensive are favored because they use a wider variety of inks. The piezoelectric printhead includes a diaphragm, a plurality of piezoelectric actuators comprising a lead-free piezoelectric material, at least one nozzle, at least one ink chamber, a top electrode, and a drive circuit. The deflection of the diaphragm on the body chamber contributes to a pressure pulse that is used to eject a drop of liquid from the nozzle. According to an exemplary embodiment, a lead-free piezoelectric printhead operated at smaller thicknesses and significantly higher electric fields is disclosed, along with methods of making such printheads.
US10252523B2	Element substrate, printhead, and printing apparatus An element substrate comprises: a plurality of heat elements which include a first heat element and a second heat element configured to supply heat to a liquid for printing; and a plurality of driving circuits which include a first driving circuit configured to drive the first heat element and a second driving circuit configured to drive the second heat element, wherein the plurality of heat elements and the plurality of driving circuits are stacked and arranged on the element substrate, and the first heat element is arranged so as to overlap at least a part of the second driving circuit when viewed from a direction perpendicular to the element substrate.
US10252520B2	Digital printing press A digital printing press including a printing cylinder configured to transport a sheet, a driving device (41) configured to drive the printing cylinder, an encoder (44) configured to detect the phase of the printing cylinder, and first to fourth inkjet heads configured to print the sheet. The digital printing press includes a floating detector facing the printing cylinder and configured to detect an abnormality of the sheet, a display device, and a control device configured to control an operation of the driving device. The control device includes a function of stopping the driving device when the floating detector detects a floating portion. The control device includes a function of obtaining information specifiable a position of an abnormality occurrence portion based on the phase of the printing cylinder when the floating detector detects the floating portion and the phase of the printing cylinder when the driving device stops after floating detection and displaying the information on the display device. The digital printing press is capable of quickly specifying an abnormality occurrence portion detected during printing.
US10252519B2	Liquid ejecting apparatus and liquid usage amount calculation method for liquid ejecting apparatus A liquid ejecting apparatus includes a liquid ejecting unit that has a plurality of nozzles and performs a recording process by ejecting liquid drops from the nozzles to a recording medium, an ejection abnormality detecting unit that detects ejection abnormality in the nozzles, a counting unit that counts the number of liquid ejections to be performed using the nozzles in the recording process as the number of scheduled ejections, and a calculation unit that calculates a usage amount of liquid in the recording process as a liquid usage amount on the basis of the number of scheduled ejections which is counted by the counting unit and a state of the ejection abnormality which is detected by the ejection abnormality detecting unit.
US10252518B2	Correction data generating apparatus, inkjet head, and inkjet printer A correction data setting apparatus, which sets correction data in a memory for storing the correction data for correcting a pulse width of a drive pulse signal applied to each actuator corresponding to each nozzle of an inkjet head, comprises a generation section which sequentially generates a channel No. for individually identifying each nozzle; an output section which outputs a parameter required for arithmetic which represents a characteristic of a correction amount with respect to an arrangement direction of the nozzles; an arithmetic section which executes the arithmetic using the parameter output from the output section to calculate the correction amount for each channel No. generated from the generation section; a conversion section converts the correction amount calculated for each channel No. by the arithmetic section to the correction data; and a setting section sets the correction data obtained for each channel No. by the conversion section in the memory.
US10252513B2	Combining structures in a three-dimensional object Certain examples described herein relate to the use of three-dimensional threshold matrices in the production of three-dimensional objects. In one case, data values for a three-dimensional matrix for use in halftoning are assigned based on a structural volume coverage representation. In certain described cases, the structural volume coverage representation defines a probabilistic distribution of at least two different structures available for the production of the three-dimensional object. A convex combination of the at least two different structures is determined, based on data values of the structure volume coverage representation. A data value may be assigned to the three-dimensional matrix based on the convex combination determined. The resultant three-dimensional matrix is used in a halftoning operation to control a structure distribution in the three-dimensional object.
US10252509B2	System and process for evaluating and validating additive manufacturing operations A method of evaluating and validating additive manufacturing operations includes generating a multidimensional space defined by a plurality of bounds, each of the bounds being defined on a distinct parameter of an additive manufacturing process and each of the parameters affecting the occurrence of a keyhole porosity flaw, each of the parameters being a dimension in a multi-dimensional coordinate system, determining a coordinate position of at least one additive manufacturing operation within the multi-dimensional coordinate system, and categorizing the operation as free of keyhole porosity flaws when the coordinate position is within the multi-dimensional space.
US10252504B2	Method and apparatus for transfer lamination A method for producing a smooth coating on a substrate includes applying a release coating to a first side of a film, applying an application layer to said first side of said film over said release coating, bonding said first side of said film to a first substrate, applying a printable coating to a second side of said film while said first side of said film is bonded to said first substrate, and removing said film from said first substrate leaving said application layer deposited on said first substrate and said printable coating on said second side of said film.
US10252501B2	PVC flooring A polyvinyl chloride (PVC) flooring, includes a wear-resistant layer, a decorative layer and a substrate layer from top to bottom in order, wherein the substrate layer comprises a flexible layer, a strength layer and a correction layer from top to bottom in order and the hardness of the strength layer is 1.05-1.10 times that of the flexible layer and the correction layer.
US10252497B2	Multilayer composition for packaging A multilayer composition for packaging comprising a first polymer film, a second film, at least one print layer between the films and a 1 K isocyanate prepolymer adhesive layer between the at least one print layer and one of the films, where the print layer contains a hyperbranched polyester binder containing functional groups selected from the group consisting of —OH, —COOH and —COOR, where R is methyl, ethyl, vinyl, isopropyl, n-propyl, n-butyl, isobutyl, sec-butyl or tert-butyl provides packaging laminates with excellent adhesion. The hyperbranched polyester is for example a polymer of trimethyolpropane and hexahydrophthalic anhydride and optionally a cycloaliphatic diol.
US10252493B2	Polymer interlayers having improved sound insulation properties A polymer interlayer comprising a layer comprising a poly(vinyl acetal) resin having a residual hydroxyl content and a residual acetate content, and a plasticizer, wherein the residual hydroxyl content, the residual acetate content and the plasticizer are selected such that the polymer interlayer has at least one glass transition temperature less than about 20° C. and a peak tan delta of greater than 1.33, and a glass panel having a configuration of 2.3-mm glass//interlayer//2.3-mm glass and at 20° C. has a transmission loss, TLw, of greater than 42 decibels as measured by weighted average sound transmission loss at 2000 to 8000 Hz, and a transmission loss, TLc, of greater than 38 decibels at the coincident frequency is disclosed.
US10252491B2	Structure integrated by vacuum-pressure forming or vacuum forming, and manufacturing method thereof A structure comprising a decorative sheet having a surface layer and an adhesive layer containing a polymer having 25 to 100 mass % of propylene units, and a substrate containing a polymer having 25 to 100 mass % of propylene units. The decorative sheet and the substrate are integrated by vacuum-pressure forming or vacuum forming.
US10252487B2	Additive manufacturing method and apparatus An additive manufacturing method and apparatus is described for the printing of three-dimensional (3D) objects. The approach is based on a composite-based additive manufacturing process, except it uses commercial printing methods to achieve even higher speed and throughput. By using the invention, a prototyping and/or production process may be completed in hours rather than months, and the risks and problems of molds is eliminated. There is substantial improvement in the number and type of geometries that can be produced compared to injection molding, and the range of materials is enlarged as are the material properties. The method involves printing a substrate having at least one sheet using a printing technology, and stacking or folding the at least one sheet to form multiple layers consistent with that formed by a 3D model. The printing step is done using a printing technology such as flexography, lithography, offset, gravure, waterless printing, and silkscreen.
US10252486B2	Utility mat One example includes a utility mat. The utility mat includes a first material layer comprising a rubber material. The utility mat also includes a second material layer overlying the first material layer and comprising a geotextile material. The utility mat further includes an adhesive material configured to bond the first material layer and the second material layer together.
US10252485B2	Sheet binding processing apparatus, sheet post-processing apparatus having the sheet binding processing apparatus, and image forming system having the sheet post-processing apparatus A sheet binding processing apparatus including a crimp binding member that performs binding processing on a predetermined region of a sheet by sandwiching and pressing the sheet between an upper tooth and a lower tooth meshing with each other, and a detection unit that detects a state of the predetermined region of the sheet to be bound by the crimp binding member. If the detection unit detects that the predetermined region is not capable of binding, the binding processing on the predetermined region is prohibited.
US10252481B2	Method for forming golf ball and mold therefor A method for forming a golf ball provides a core member comprising a core of a golf ball into a cavity of a mold so that the core member is supported by a movable holding pin disposed in the mold; forming a layer outside the core member by injecting a material of the layer into the cavity; and retracting the pin from the cavity into the mold during the material injection so that a portion projecting from a surface of the layer is formed by a tip of the pin, the projecting portion having a site area of at least 0.2% in relation to an entire area of the tip of the pin and having a height of at least 0.2 mm. This method can be implemented by controlling the retraction of the pin, or alternatively by using the pin having a predetermined indentation portion on the tip.
US10252477B2	Mechanical assembly housing An apparatus (10) that houses functional components of a mechanical assembly includes a frame component (12) formed of a first material, the frame component (12) bearing primary load, torque or pressure applied to the apparatus (10) during operation of said mechanical assembly. The housing apparatus (10) further includes a composite reinforcement component (130) for resisting forces applied to the apparatus during operation of the mechanical assembly and an enclosure component (80) formed of a second material of lower density than the first material of the frame component (12), the enclosure component (80) covering and sealing at least the functional components of the mechanical assembly from external conditions during operation of the mechanical assembly.
US10252476B2	Repeating unit, multi-needle machine and method for producing reinforced materials The embodiment relates to the production of reinforced materials, for example reinforced foam materials or reinforced textiles. A multi-needle machine is provided with a plurality of serially arranged repeating units, which are able to move sliders and pins toward and past each other along a circular path so as to create the semi-finished textile products. In this way, it is possible to reinforce components with curved surfaces.
US10252474B2	Temperature determination based on emissivity An additive manufacturing system may include a controller to determine an emissivity of a portion of a layer of build material based on a measured optical property of the portion, or based on object design data representing a degree of intended solidification of the portion. The controller may be to determine a temperature of the portion based on the determined emissivity and a measured radiation distribution emitted by the portion.
US10252473B2	Compression bar apparatus Provided is a compression bar apparatus for applying pressure to desired areas of a thin film composite (TFC) membrane, such as spiral wound TFC membranes and elements, including membranes and elements used for nanofiltration, reverse osmosis or forward osmosis to purify water, such as tap water, seawater, and brackish water. Application of pressure to a spiral wound element by the apparatus produces a membrane with increased sealant penetration, reduced osmotic blistering, and minimal damage to the active area of the membrane. Also provided are methods of using the apparatus.
US10252472B2	Method for joining fiber-reinforced plastic material A method is provided for joining a fiber-reinforced joining element, formed from a plastic material, to the joining surfaces thereof by way of an ultrasonic welding method. A concentrator and/or at least one insertion element is arranged in the region of the joining surfaces prior to fusing between the joining surfaces, and the concentrator and/or the insertion element are fused together with the joining surfaces in order to form a positive fit joint therewith after hardening.
US10252470B2	Automated edge band application for non-linear work pieces An automated edge band application machine has a board drive assembly and an opposed caster wheel that together capture and move a work piece edge into engagement with a rotating roller banding guide with edge banding captured between. An adhesive affixes the edge banding to the work piece responsive thereto. An edging detector is located along the path of the work piece edge, in a position in advance of the board drive assembly, and is configured to detect a presence of edge band on the edge of the work piece. When the edging detector detects edging, or at a precise distance along the edge band thereafter, a cutting die assembly severs the edge band. The board drive assembly automatically adjusts to varying thickness work pieces, engages with a work piece major surface, and rotates in synchrony with a drive spindle assembly and the rotating roller banding guide.
US10252465B2	3-dimensional printing apparatus and dispensing device The present disclosure provides a dispensing device and a 3-D printing apparatus including the same. The dispensing device comprises a main body with a main body heater, a head portion and a heating device. The main body includes a passage with a longitudinal axis and the main body heater is used for heating the material in at least a section of the passage to a flowable condition. The head portion is connected to an end of the passage and communicates with the passage and further includes an outlet for discharging the heated material. The heating device includes a peripheral path surrounding the head portion and heats a region surrounded by the peripheral path.
US10252459B2	Mold element for forming a container, provided with pressure-release air vents in the form of slots A one-piece mold element (3, 7) for a mold (1) for manufacturing containers from blanks of plastic material by blow molding or stretch blow molding. The mold element (3, 7) includes a one-piece molding wall (4, 8) having a raised molding surface (5, 9) bearing the imprint of at least one portion of a container, the molding wall (4, 8) having at least one decompression vent (20) extending therethrough, the hole leading, via an inner opening (21), onto the molding surface (9), which is provided in the form of a slot.
US10252450B2	Reinforced thermoplastic products and methods of making the same A reinforced thermoplastic product may include a main body and a fabric reinforcing sheet that is disposed within a wall of the main body. The wall of the main body may be formed of or from a cast thermoplastic material and the fabric reinforcing sheet may extend circumferentially around the main body in order to reinforce the wall. The fabric reinforcing sheet may include a plurality of fiber bundles and a thermoplastic material that impregnates each fiber bundle.
US10252445B2	Manifold assembly for resin infusion and injection A manifold for resin application, infusion, and/or injection is provided. The manifold comprises at least one inlet and a plurality of outlets. At least one outlet of the manifold comprises a valve that is operable to selectively dispense or terminate a flow of a resin from the outlet, and wherein the resin is supplied through the at least one inlet.
US10252442B2	Method for manufacturing ceramic formed body, and apparatus for manufacturing ceramic formed body A manufacturing method includes: a dry mixing step of dry mixing a raw material by batch processing; a wet mixing step of adding liquid to a dry mixture obtained at the dry mixing step, the liquid including at least one type of water, surfactant, lubricant and plasticizer, while wet mixing; a kneading step of kneading a wet mixture obtained at the wet mixing step; and a forming step of extruding a kneaded mixture (forming raw material) obtained at the kneading step to make a ceramic formed body. In the kneading step, the liquid is further added during kneading of the wet mixture.
US10252437B2	Line for processing a continuous web material and related method The line comprises a feed path (P) of the web material (N) and, along the feed path, a transverse cutter (5) for cutting scraps (FS) from the continuous web material (N). The line includes a system for removing scraps of web material cut by the cutter. The system for removing scraps is fitted with a scrap accumulator member (21). The accumulator member (21) is movable in a direction generally parallel to the feed path (P) of the web material between: a position for receiving scraps, wherein the distance between the accumulator member (21) and the cutter (5) is such that scraps (FS) generated by the cutter (5) are collected by the accumulator member (21); and a standby position, at a distance from the cutter (5) such that scraps (FS) generated by the cutter are collected in a space (D) between the cutter (5) and the accumulator member (21).
US10252433B2	Razor with a resilient holder The invention relates to a razor and a method for producing a razor. To make available an improved razor, a razor (1) has a handle (10) with a lower face (12) for placing on the skin of a user, and with an upper face (11) which lies opposite the lower face and is placed in the hand of the user, and a blade head (20) with at least one razor blade (21) at a head end of the lower face, wherein the lower face and upper face are fixed to each other at a respective handle end (15) and are designed to be spaced apart from each other at a respective head end (16), and wherein the lower face, in at least one subregion (34) between the handle end and the head end, is advantageously more elastic than the opposite subregion of the upper face.
US10252429B2	Stationary cutting blade for a hair clipping device A stationary cutting blade for a hair clipping device has a base body and a coined cutting teeth. The coined cutting teeth are spaced apart from each other, arranged on a front side of the base body, and each extend parallel to a longitudinal axis of the stationary cutting blade. A thickness ratio between the thickness of the base body and the thickness of the cutting teeth is larger than 1.1. Each cutting tooth has a substantially wedge-shaped cross-section with a scissor angle and a wedge angle, where the sum of the scissor angle and the wedge angle is smaller than 70°.
US10252426B2	Handling module for handling motor vehicle wheels A handling module for handling vehicle wheels in an installation for the surface treatment thereof and having at least two gripping units which are supported by a frame structure and each of which comprises a plurality of press-on elements which are pressable onto one or more counter surfaces of an individual vehicle wheel. At least one of the gripping units includes a translation device by which the press-on elements are movable in relation to the frame structure with a movement component which is parallel to the axis of rotation of a gripped vehicle wheel.
US10252418B2	Load parameter setting method and load parameter setting device A load parameter setting device includes: a storage unit that stores a plurality of load parameters corresponding to a plurality of types of workpieces to be gripped by the robot respectively; an index calculation unit that calculates, for each of the plurality of stored load parameters, an index for selection of the load parameter of the workpiece gripped by the robot based on a current position and orientation of the robot; and a selection unit that selects the load parameter of the workpiece from among the plurality of load parameters stored in the storage unit based on the calculated index.
US10252416B2	Article conveying device having temporary placement section An article conveying device having a temporary placement section and capable of conveying articles. The article conveying device has: a supplying section configured to sequentially convey or supply plural articles; a discharging section configured to sequentially convey plural containers for containing the articles; a temporary placement section on which at least one article can be temporarily placed; a first detecting section configured to detect a position/posture of the article on the supplying section and successively detect an amount of movement of the supplying section; a second detecting section configured to detect a position/posture of the container on the discharging section and successively detect an amount of movement of the discharging section; a working machine configured to convey the article between the supplying section, the temporary placement section and the discharging section; and a controlling section configured to control the working machine based on a predetermined condition.
US10252413B2	Robot and robot system A robot of the invention can be moved by a carrying apparatus, and in which a period between a settling start time and a settling end time of the robot overlaps with at least a part of a period between a settling start time and a settling end time of the carrying apparatus. Further, the settling start time of one having a shorter settling time of the robot and the carrying apparatus is later than the settling start time of the other having a longer settling time of the robot and the carrying apparatus or the same as the settling start time of the other having the longer settling time.
US10252412B2	Mobile robot In mobile robot that runs from first flat surface which is a magnetic body to second flat surface which is a magnetic body and intersects the first flat surface, the mobile robot includes a pair of driving wheels which is rotatably supported to robot body and includes permanent magnets on outer circumferential surfaces thereof; driving mechanism which drives the pair of driving wheels to be independently rotated; rear wheel which is rotatably supported to the robot body and includes permanent magnets on an outer circumferential surface thereof; distance sensor which acquires a distance to the second flat surface; and pressing out mechanisms which include pressing out members which are movable between contact position at which the pressing out member can be in contact with the first flat surface and retracted position at which the pressing out member is retracted from the first flat surface. The pressing out member is moved from the retracted position to the contact position to be in contact with the first flat surface by the pressing out mechanism, the driving wheels is separated from the first flat surface, and the driving wheels move from the first flat surface to the second flat surface, when the distance sensor detects that the driving wheels are in contact with the second flat surface.
US10252410B2	Rotatable fixturing platform Systems, methods, and apparatus for a rotatable fixturing platform having a rotisserie, a modular fixturing platform, and a mounting assembly. The rotisserie includes a base with an extensible frame. The extensible frame includes a plurality of support assemblies and a plurality of extensible arms. Each extensible arm extends from one of the support assemblies and has a bearing. The mounting assembly includes a plurality of mounting brackets coupled to the fixturing platform and an axle assembly. The axle assembly is secured to bearings of the extensible arms.
US10252409B2	Magnetically cleaning fabric surfaces A magnetic cleaner distributes ferromagnetic cleaning particles to a surface to agglomerate dirt and dust, agitates the cleaning particles on the surface so that dirt particles adhere to the cleaning particles, and collects the dirt laden cleaning particles. A dispenser for holding and dispensing the ferromagnetic cleaning particles, an agitator to agitate the ferromagnetic particles on the surface, a magnetic collector for picking up ferromagnetic cleaning particles from the surface, and a dirt cup for collecting the ferromagnetic cleaning particles picked up by the collector are provided by the cleaner.
US10252408B2	Staple remover A staple removal device for removing a staple and wire arrangement from a fence post includes a main body having a first jaw and a second jaw spaced apart from each other. The first jaw and second jaw provide a first and second elongate channel respectively for receiving the wire. Both the first and second elongate channels comprise a closed end in which the wire may be received. A gripping portion is moveably connected to the main body and a lever causes movement of the gripping portion. Beneficially, a first and second block portion is configured at a surface of the main body wherein a side edge of the first and second block portion is substantially in alignment with the closed end of the first and second channel respectively so as to, in use, increase the surface area of the contact region between the staple removal device and the wire.
US10252406B2	Indirect firing fastening tool with anti-firing trigger support An indirect firing fastening tool with an anti-firing trigger support. The tool comprises, in one case, an axially movable equipment with a tip guide projecting from the case to drive a fastening member into a support material, a reception housing for a fastener charger and anti-firing safety means to prevent the recoil of the tip guide. Advantageously, an anti-firing trigger support is mounted on said reception housing to convert the tool into a mono-firing tool, the trigger being arranged to cooperate with the anti-firing safety means so as to remove them and authorize firing.
US10252405B2	Bolt tensioning system Embodiments disclosed herein generally relate to a system and method for tensioning a bolt. The bolt tensioning system may be used with variable length connection members, for example studs, in any one or more of the drilling, subsea, and process industries to couple a first member to a second member. The bolt tensioning system may remain coupled to the first member and the second member, while applying tension to all of the bolts at the same time, rather than having to torque or tension each bolt individually. The bolt system may accurately and uniformly tension all bolts in a single operation to provide reliable connections.
US10252399B2	Abrasive jet system An abrasive jet system for producing an abrasive cutting jet is provided. The system includes a source of abrasive suspension connected via a conduit to a cutting head. A source of displacement fluid is provided to flush abrasive suspension in the conduit towards the source of abrasive suspension, when the pressure at the source of abrasive suspension is below the pressure at the source of displacement fluid and no water jet is present in the cutting head. Also provided is a method for suspending a settled or partly settled bed of abrasive.
US10252396B2	Polishing pads and systems and methods of making and using the same The present disclosure relates to polishing pads which include a polishing layer, wherein the polishing layer includes a working surface and a second surface opposite the working surface. The working surface includes at least one of a plurality of precisely shaped pores and a plurality of precisely shaped asperities. The present disclosure further relates to a polishing system, the polishing system includes the preceding polishing pad and a polishing solution. The present disclosure relates to a method of polishing a substrate, the method of polishing including: providing a polishing pad according to any one of the previous polishing pads; providing a substrate, contacting the working surface of the polishing pad with the substrate surface, moving the polishing pad and the substrate relative to one another while maintaining contact between the working surface of the polishing pad and the substrate surface, wherein polishing is conducted in the presence of a polishing solution.
US10252394B2	Pressing device having a toothed belt A pressing device (1) for pressing finishing tape against circumferential surfaces (2) of substantially cylindrical work piece sections (3) in a finishing process includes at least one elastically bendable pressing element (5) that is substantially inelastic in the longitudinal direction. A support element (6) has two bearings (7), which are arranged at a distance from each other. The pressing element (5) is fastened to the two bearings, and the two bearings are arranged in such a manner that finishing tape is pressed against a circumferential surface (2) by the pressing element (5) across a contact angle (4) using a pressing force. The pressing device (1) is adjustable in order to process work piece sections (3) of different diameters. The pressing element may be a toothed belt (5) having tooth-like ribs (8), and the toothed belt (5) is interlockingly mounted in the support element (6) using the tooth-like ribs (8).
US10252393B2	Component manufacturing method and polishing apparatus A component manufacturing method includes causing a holding member to hold a workpiece such that a spherical center of a processed surface of the workpiece is located on a supporting member; rotating the workpiece by rotating the holding member; and polishing the workpiece by moving the supporting member to move the workpiece on a polishing tool, with the spherical center of the processed surface located at a spherical center of a processing surface of the polishing tool.
US10252388B2	Feed axis device of a machine tool The feed axis device of a machine tool is equipped with first and second planetary gear speed reducers, each of which is obtained from an inner element, outer element, and intermediate elements that are disposed between the two, the elements being disposed so as to be mutually rotatable and combined in series so that one of the three elements is a fixed section, one of the two remaining elements is the input section and the other is the output section. The element that is the input section of the first speed reducer and the element that is the input section of the second speed reducer are connected to a single drive source. The element that is the output section of the first speed reducer and the element that is the output section of the second speed reducer are connected. The feed axis device is provided with an actuator.
US10252387B2	Balancer mechanism for rotating shaft A balancer mechanism for a rotating shaft is configured to prevent deviation of the axis of the rotating shaft. The balancer mechanism (20) has an assistance torque generation device (21) for generating an assistance torque. The assistance torque generation device (21) includes a cam member (24) fixed to the rotating shaft (4), a cam follower member (25) and a gas spring (27). The balancer mechanism has a reaction force generation device (22) provided for generating, a balancing moment on the rotating shaft that cancels out a tilting moment that tilts the rotating shaft (4) around a bearing member (9) in a direction to separate it from the assistance torque generation device (21) and which is caused by the biasing force of the gas spring (27).
US10252384B2	Automated assembly apparatus and automated assembly method An automated assembly apparatus comprises an assembly robot that includes a Y-axis movement unit, a first X-axis movement unit movable in a Y-axis direction along the Y-axis movement unit, and a grip unit movable in an X-axis direction along the X-axis movement unit, and a workbench unit including a Z-axis movement unit arranged below the assembly robot with respect to an Z-axis and a workbench movable in the Z-axis direction along the Z-axis movement unit, wherein an assembly operation for a first assembly component gripped by the grip unit and a second assembly component mounted on the workbench unit is performed through movement in the Z-axis direction by the workbench unit.
US10252381B2	Jack foot retraction system A system for supporting a vehicle. The system may include a vehicle jack in mechanical communication with a jack foot and a striker plate. The jack foot is rotatable relative to the vehicle jack on a rotation axis disposed on the vehicle jack and perpendicular to a long axis of the vehicle jack. The jack foot includes a base at a distal end of the jack foot. The jack foot also includes a cam surface at least in part at a proximal end of the jack foot. The cam surface is aligned with the striker plate and interacts with the striker plate to rotate the jack foot in response to movement of the vehicle jack from a lowered position to a raised position.
US10252380B2	Repair or remanufacture of blade platform for a gas turbine engine A method of remanufacturing a turbine component includes electrical discharge machining a puck via the turbine component to form an electrical discharged machined puck; and brazing the electrical discharged machined puck to the turbine component.
US10252379B2	Brazing material for bonding; and composite part and cutting tool using same A cutting tool including a cutting edge part made of cBN sintered material bonded through a brazing material for bonding and a cutting tool body made of WC-based cemented carbide is provided. In the cutting tool, the cutting edge part made of cBN sintered material and the cutting tool body made of WC-based cemented carbide are brazed by using a blazing material for bonding including: 35-40% of Ti in a mass ratio; 35-40% of Zr in a mass ratio; 5-15% of Ni in a mass ratio; and the Cu balance including inevitable impurities.
US10252376B2	Welded lap joint with corrosive-protective structure The present invention includes a system, method, and apparatus for preventing corrosion in a lap joint. The lap joint includes a first member and a second member. The first member is adjacent to the second member to form a lap seam of the lap joint. The first member forms a channel at the lap seam relative to the second member. The channel forms a “V” shape, a “U” shape, or a semicircle shape relative to a horizontal plane of the lap joint. One or more openings are formed on the first member and/or the second member. The openings and channel of the present invention allows anticorrosion material to coat the lap seam of the lap joint.
US10252374B2	System and method for laser cladding in controlled environment A laser cladding system includes a laser apparatus, a chamber, and a pump system. The laser apparatus is configured to generate a laser beam. The chamber includes an interior surface that defines a cladding area comprising a sealed volume. The chamber includes a window that is made from a laser-transparent material and is configured to allow the laser beam to pass therethrough into the cladding area. The pump system has a port in communication with the cladding area. The pump system is configured to selectively generate a vacuum pressure within the cladding area sufficient to evacuate gas from within the cladding area out through the port. The laser apparatus includes a laser head from which the laser beam is emitted and a robotic laser motion system configured to selectively move the laser head such that the laser beam moves relative to a reference point within the chamber.
US10252373B2	Laser processing machine with weight compensation Described is a laser processing machine with a height-adjustable laser component, a height-adjustable machine component, and a weight compensation system. The weight compensation system has at least one roller unit that includes at least two rollers fastened on a common axle and rotatably fixed with respect to one another. The axle is configured to rotate freely and slide in a machine frame guide of the laser processing machine. The laser component is held suspended by a first traction member wound onto the first roller. The machine component is held suspended by a second traction member wound onto the second roller. The first traction member and the second traction member are wound in reverse (opposite) directions onto the rollers. A counterweight device acts on the axle by exerting a counterforce, which compensates, at least partially, for the forces exerted by the laser component and the machine component.
US10252371B2	Diffusion-bonded metallic materials A method includes disposing a hydride of a transition metal on a first metallic material, where at least one of the first metallic material or a second metallic material includes a surface oxide layer. The method includes performing a diffusion bonding operation to bond the first metallic material to the second metallic material. During the diffusion bonding operation, the hydride of the transition metal chemically reacts with the surface oxide layer.
US10252368B2	Machine vision robotic stud welder The present disclosure teaches systems and methods for robotic welding of studs onto the surface of I-beams. These systems and methods will find industrial applicability in, for example, the steel erection industry.
US10252365B2	Deposition of braze preform A method of manufacturing includes depositing a braze filler adjacent to a void between a first component and a second component thus holding the components in position before brazing. The first and second components are heated to melt and flow the braze filler into the void. A braze joint is formed between the first and second components by cooling the braze filler. Depositing the braze filler can include laser cladding the braze filler to the first and/or second components adjacent the void. The method also optionally includes welding the first and second components in position with the braze filler adjacent to the void. The braze filler may be deposited as a powder, cold spray, melted brazed filament, spherical ball or any other suitable form.
US10252359B2	Method for determining the flank face contour of a gear skiving tool, gear skiving tool and use thereof A clearance angle, of a blade-like tool or tool tooth of a tool for hob peeling workpieces is determined by defining the rake face contour of the tool and calculating the progression of path movement of the rake face during chip-breaking hob peeling, taking into account a pre-determinable transmission ratio between the tool and the workpiece determined by the respective number of teeth, and the desired tooth cross-section contour of the tool, and determining a tangential speed for points of the cutting edge of the tool during chip-breaking, wherein hob peeling is determined in the form of vectors that are displayed graphically as bundles for each point on the cutting-edge and a closed envelope surface is determined, which plus a desired clearance angle is selected as the shape for the flank face contour of the tool or of the flank face of the tool tooth. A tool is also provided.
US10252351B2	Step drill bit A drill bit includes a shank, a transition portion, and a body portion defining a plurality of axially stacked, progressively sized steps. The steps include a first step and a terminal step coupled to the transition portion. The first step defines two tip flutes each disposed at a tip flute angle. The body portion defines a body flute extending from the first step to the transition portion. The drill bit also includes an indicator band formed on a portion of the body flute and a portion of an outer surface of one of the plurality of steps.
US10252349B2	Forward grip system A forward grip system is disclosed for supporting a paintball gun. The forward grip system has an inner, longer, hollow cylindrical body with threaded sections with two conical ends with slits around them. The middle section of the inner, longer, hollow cylindrical body has a groove for the outer, shorter, hollow cylindrical body to rotate around on. The edges of the grooved middle section of the inner, longer, hollow cylindrical body are raised to secure the outer, shorter, hollow cylindrical body within the grooved middle section as it rotates around the inner, longer, hollow cylindrical body. A vertical shaft is connected onto the outer, shorter, hollow cylindrical body to function as the handle. There are two threaded locking collars for engaging each of the threaded sections of the inner, longer, hollow cylindrical body for the purpose of locking the forward grip system in place onto a paintball barrel.
US10252348B2	Compensating chuck A compensating chuck for concentrically clamping workpieces. The chuck has a drive unit having two pairs of entrainment members, wherein the entrainment members are preferably slidingly mounted, are respectively movable in paired relationship, and are so coupled to a respective one of the main jaws that a relative movement of a respective pair causes a synchronous movement of adjacent main jaws and that both a relative movement relative to each other with respectively different movement components and also a synchronous movement of the adjacent entrainment members in the same direction respectively causes a relative movement of adjacent main jaws.
US10252347B2	Self-locking drill chuck A self-locking drill chuck includes rotating sleeve provided with a convex leaf spring fixed on a rotating sleeve on both ends, its nut or the ring fixedly connected with the nut provided with a first groove and a second groove matching with the convex portion of the convex leaf spring, and the self-locking structure including a ring tooth on the drill body and a rotatable locking block disposed on the nut or ring fixedly connected to the nut. The nut or ring fixedly connected to the nut is also provided with a leaf spring, and the rotating sleeve is provided with a first part compressing the leaf spring and a second part compressing the locking block. The self-locking drill chuck can achieve positioning fit of metals, and self-locking and unlocking switching is realized by the lever without the interference phenomenon in the self-locking structure.
US10252345B2	Machine tool A machine tool includes a movement device, which has a first feed shaft and a second feed shaft that mutually intersect, and a plurality of tools, which are driven by the movement device and respective blade edges of which are staggered stepwise. The blade edges of the tools are aligned with the second axis due to the inclination of the tools as a unit. The machine tool is capable of executing center level adjustment of a plurality of tools mounted on a tool post against a workpiece having a larger diameter, and is also capable of reducing wasted time in non-cutting operation via equal stroke lengths of the tools.
US10252343B2	Surface-coated cutting tool and method of producing the same A surface-coated cutting tool includes a base material and a coating formed on a surface of the base material. The coating includes a first hard coating layer including crystal grains having a sodium chloride-type crystal structure. The crystal grain has a layered structure in which a first layer composed of nitride or carbonitride of AlxTi1-x and a second layer composed of nitride or carbonitride of AlyTi1-y are stacked alternately into one or more layers. The first layer each has an atomic ratio x of Al varying in a range of 0.6 or more to less than 1. The second layer each has an atomic ratio y of Al varying in a range of 0.45 or more to less than 0.6. The largest value of difference between the atomic ratio x and the atomic ratio y is 0.05≤x−y≤0.5.
US10252332B2	Powder processing arrangement and method for use in an apparatus for producing three-dimensional work pieces A powder processing arrangement (10) for use in an apparatus (100) for producing three-dimensional work pieces by selectively irradiating a raw material powder with electromagnetic or particle radiation comprises a carrier element (16) having a build section (46) adapted to carry a raw material powder layer while being selectively irradiated with electromagnetic or particle radiation and at least one transfer section (48a, 48b) adapted to carry the raw material powder prior to being applied to the build section (46) so as to form the raw material powder layer to be selectively irradiated with electromagnetic or particle radiation. The powder processing arrangement (10) further comprises a heating device (50) adapted to pre-heat the raw material powder carried by the transfer section (48a, 48b) of the carrier element (16) prior to being applied to the build section (46) of the carrier element (16) so as to form the raw material powder layer to be selectively irradiated with electromagnetic or particle radiation.
US10252331B2	Silver powder, method for producing same, and conductive paste A silver powder, including: an organic substance on a surface of the silver powder, the organic substance containing at least one carboxyl group and at least one hydroxyl group in one molecule of the organic substance, wherein a ratio of (Casson yield value/BET specific surface area) is 500 or less, where the Casson yield value is a Casson yield value of a conductive paste and the BET specific surface area is a BET specific surface area of the silver powder, where the conductive paste has a composition in which the silver powder is 86% by mass, a glass fit is 1% by mass, ethyl cellulose is 0.6% by mass, texanol is 10.5% by mass, and zinc oxide is 1.9% by mass, and the conductive paste is prepared by kneading the composition with a planetary centrifugal stirrer and bubble remover and dispersing with a triple roll mill.
US10252330B2	Pouring metallic plug stick clamping mechanism for cast steel wheels A pouring metallic plug stick clamping mechanism for cast steel wheels. The mechanism includes: a cast iron frame, a plurality of grooves, a centrally located opening in the frame, a first white ceramic ball, a second white ceramic ball, a third white ceramic ball, a retaining spring, a pressure regulating bolt, a control press button, a metallic plug stick, and a blocking iron piece.
US10252323B2	Manufacturing method for cylinder head A manufacturing method for a cylinder head is described. A masking member is attached to cylinder head material, which followed by a film formation step. The masking member comprises a mask portion to mask the matching surface with the cylinder block, and mask portions to mask each of the openings of the intake ports, the exhaust ports, and the CPS hole. Mask portions are linked directly to other mask portions without any steps.
US10252319B2	Method for production of two-piece can A laminated steel sheet for a two-piece can body with a high strain level satisfying the following formulae, the polyester resin layer composing the laminated steel sheet having a center line surface roughness (Ra) of 0.2 μm to 1.8 μm: r1≤r,0.1≤r1/R≤0.25, and 1.5≤h/(R−r)≤4 wherein h is the height of the two-piece can body, r is the maximum radius, r1 is the minimum radius, and R is the radius of the circular laminated steel sheet before forming having the same weight as the can body.
US10252317B2	Die button A die button for the punching in and fastening of a fastener element having a piercing section to a planar workpiece, in particular a sheet metal part. The die button includes a jacket. Also included is a die plunger movably arranged in the jacket. Further included is a biasing device for pressing the plunger against the workpiece when the workpiece is supported on the jacket with a pressing force made available by the biasing device and selected such that the die plunger first moves when a slug has been detached from the workpiece by the piercing section of the fastener element.
US10252314B2	Method of manufacturing pure niobium plate end-group components for superconducting high frequency accelerator cavity Targeting mass production, the present invention provides an advanced method of manufacturing pure niobium plate end-group components from pure niobium plate material for superconducting high frequency accelerator cavity by means of innovative shear-blanking followed by innovative forging procedures, wherein the invention is to convert the procedure/production method from the conventional machining or waterjet cutting followed by the conventional cold forging to the whole press-forming The invention gives the drastic effects on cost-effectiveness and press-performance.
US10252307B2	Highly-viscous substance dispensing method and highly-viscous substance dispensing apparatus Each time a highly-viscous substance is extruded, a variation in weight of each cut piece of the highly-viscous substance is minimized. Metallic sodium (5) loaded in an extruder main body (3) is extruded from a nozzle (7) of the extruder main body (3) with a pressing tool (4) and, when it is detected that the metallic sodium (5) is extruded to a predetermined position, the movement of the pressing tool (4) is stopped and the extruded metallic sodium (5) is cut. In this case, an impulse (P) after stop is brought closer to a constant value until a load no longer acts on the metallic sodium (5) in the extruder main body (3) after stopping the movement of the pressing tool (4) by adjusting the movement speed of the pressing tool (4).
US10252306B2	Apparatus and methods to increase the efficiency of roll-forming and leveling systems Methods and Apparatus to increase the efficiency of roll-forming and leveling systems are described herein. An example strip material processing apparatus includes a first drive system to drive an exit workroll at an exit of the strip material processing apparatus, and a second drive system to drive an entry workroll at an entry of the strip material processing apparatus, where the strip material is to travel through the strip material processing apparatus from the entry to the exit. The example strip material processing apparatus also includes a controller to provide a first command reference to the first drive system to drive the exit workroll at the first command reference. The controller is to determine a first torque value of the first drive system when the first drive system operates at the first command reference, and the controller is to determine a second torque value based on a ratio of the first torque value to the second torque value such that the first torque value and the second torque value are different. The controller is to also drive the entry workroll via the second drive system to maintain the ratio.
US10252305B2	Flat product made of a metal material and roll and method for producing such flat products A flat product made of a metal material has been provided with deterministic surface texture which has a plurality of depressions which have a depth in the range of from 2 to 14 μm, wherein the depressions are designed to be I-shaped, H-shaped, cross-shaped, C-shaped or X-shaped, and wherein the surface texture has a peak count RPc in the range of from 45 to 180 1/cm, an arithmetic mean roughness Ra in the range of from 0.3 to 3.6 μm, and an arithmetic mean waviness Wsa in the range of from 0.05 to 0.65 μm. A roll which is particularly suitable for producing such a flat product has a deterministic surface texture which has a plurality of overlapping dimples, which are arranged such that they delimit a double-I-shaped, H-shaped, cross-shaped, C-shaped or X-shaped material texture in the roll surface, and wherein the surface texture of the roll, measured in the direction of the roll axis, is characterized by a peak count RPc in the range of from 80 to 180 1/cm, an arithmetic mean roughness Ra in the range of from 2.5 to 3.5 μm and an arithmetic mean waviness Wsa in the range of from 0.08 to 1.0 μm.
US10252297B2	Apparatus for selecting horticultural products An apparatus for selecting horticultural products includes an intake section leading to at least one passage lane defined by a pair of mutually close stems rotatably supported by a support and movement assembly and are interposed longitudinally between the intake section and a discharge section. between the pair of stems, kept inclined downward from the intake section to the discharge section, a longitudinal slot is disposed that can be crossed exclusively by debris and horticultural products having dimensions that are smaller than the width of the slot. The assembly includes a drive unit meshing with an end portion of each stem proximate to the intake section and elements for the free support of an end portion of each stem proximate to the discharge section.
US10252292B2	Method of making light weight component with internal metallic foam and polymer reinforcement A method of making a light weight component including the steps of: forming a metallic foam core into a desired configuration; applying an external metallic shell to an exterior surface of the metallic foam core after it has been formed into the desired configuration; forming an inlet opening and an outlet opening in the external metallic shell in order to provide a fluid path through the metallic foam core; and injecting a thermoplastic material into the metallic foam core via the inlet opening.
US10252287B2	Optical fiber re-coating device An optical fiber re-coating device of the invention includes an optical fiber coater that cures resin and coats a coating-removed portion of an optical fiber therewith. The optical fiber re-coating device includes: a resin reservoir tank that stores the resin which is before subjected to curing; a pump that supplies the resin stored in the resin reservoir tank to an optical fiber coater; and an air bubble separator that separates air bubbles included in the resin from the pump therefrom, sends the resin from which the air bubbles are separated to the optical fiber coater, and returns the resin including the separated air bubbles to the resin reservoir tank.
US10252285B2	Mobile drift sensor for agricultural spraying Wind speed, wind direction, and field boundary information are detected and used to identify a monitor area indicative of a likely overspray condition. Control signals are generated to deploy an unmanned aerial vehicle (UAV), with a sprayed substance sensor, to the monitor area. The UAV is controlled to reposition it, as a spraying machine moves through the field being sprayed. When an overspray condition is detected, an overspraying signal from the UAV indicating the detected overspray condition is received and overspray processing is performed, based upon the received overspray signal.
US10252280B2	Oil centrifuge having a throttle point and safety valve An oil centrifuge has an integral, rotatably mounted centrifuge rotor and a feed tube connected to the centrifuge rotor. A flow path is provided that supplies oil to the centrifuge rotor. The feed tube is a section of the flow path. The flow path has a throttle point having a reduced throttle cross section that is reduced relative to an upstream flow path cross section of the flow path upstream of the throttle point.
US10252279B2	Centrifuge having light emitting part A centrifuge including a rotor, a rotor chamber having an opening, a motor, a door configured to close the opening, an input/output unit configured to receive an input of an operating condition and to display an operating status, and a housing accommodating therein the rotor, the rotor chamber, the motor, the door and the input/output unit, wherein the housing has the opening at an upper surface thereof, wherein a light emitting part having a horizontal width longer than the opening is provided in the vicinity of a corner portion at which the upper surface and a front surface of the housing intersect with each other or in the vicinity of a front side of the opening, and wherein a light emitting form of the light emitting part is configured to be changed depending on the operating status.
US10252278B2	Centrifuge container with reduced flow resistance and set comprising a centrifuge container and a centrifuge rotor The present invention relates to a centrifuge container for a centrifuge rotor, with a base body comprising an opening, a vessel bottom and a longitudinal axis, the opening and the vessel bottom being situated opposite each other and the base body extending with its overall length between the opening and the vessel bottom, and the centrifuge container comprising, along the overall length of the base body, a first section extending from the opening and a second section extending to the vessel bottom, the centrifuge container comprising structure non-detachably connected to the container for reducing the flow resistance, the structure being provided exclusively in the region of the second section.
US10252274B2	Apparatus and method for chipping tree branches and the like and baling wood chips formed during such chipping activities The present invention relates generally to wood chippers and baling machines and methods of operation therefor, and more specifically, to an apparatus and a method for chipping tree branches and the like and baling wood chips formed from such chipping activities. The apparatus includes a chipper assembly having a chipping mechanism operable to reduce the trimmed branches to wood chips. Also provided is a bale forming assembly operatively connected to the chipper assembly. The bale forming assembly has a housing and a baling mechanism contained within an interior space of the housing. The housing has an opening defined therein for receiving wood chips from the chipper assembly. The opening provides access to the interior space of the housing. The baling mechanism is operable to form a bale from the wood chips produced by the chipper assembly.
US10252272B2	Systems and method for biological analysis A system for processing a plurality of biological samples contains a support and a temperature controller. The support is configured to hold a case that includes an inner chamber and a substrate located within the inner chamber, the substrate containing a plurality of isolated reaction sites containing one or more biological samples. The temperature controller is configured to maintain or control a temperature of at least one of the support, the case, or the one or more biological samples during an assay or reaction on the one or more biological samples. The support is also configured to maintain at least one of the surfaces of substrate at a positive angle relative to a horizontal plane during the assay or reaction.
US10252270B2	Nozzle apparatus and methods for use thereof Nozzle Assemblies and methods of use for producing a liquid jet are disclosed that may be permit adjustable time delays between mixing of fluids and observation of reactions. An example nozzle assembly includes: a housing having an inlet and an outlet and a first channel defined therebetween, where the housing includes a gas focusing aperture defining the housing outlet; an intermediate tube disposed within the first channel of the housing, where the intermediate tube has an inlet and an outlet and defines a second channel therebetween; and a central tube disposed within the second channel of the intermediate tube, where the central tube has an inlet and an outlet and defines a third channel therebetween, where the central tube outlet is longitudinally spaced apart from the intermediate tube outlet such that the intermediate tube outlet is disposed between the central tube outlet and the gas focusing aperture's inlet.
US10252269B2	Methods of sorting activated T cells using three dimensional dielectrophoresis Methods and devices are provided for focusing and/or sorting activated T cells. The device comprises a microfluidic channel comprising a plurality of electrodes arranged to provide dielectrophoretic (DEP) forces that are perpendicular to forces from hydrodynamic flows along the channel. The device may be configured to apply voltages to a plurality of electrodes in a first upper region of the microfluidic channel to focus the cells into a single flow, and to apply different voltages to a plurality of electrodes in a second downstream region of the microfluidic channel to sort cells based on size. The output of the microfluidic channel may diverge into multiple channels, wherein cells of various sorted sizes are directed into the appropriate output channel.
US10252267B2	Microfluidic device for simultaneously conducting multiple analyses Provided is a rotatable microfluidic device for conducting simultaneously two or more assays. The device includes a platform which can be rotated, a first unit which is disposed at one portion of the platform and detects a target material from a sample using surface on which a capture probe selectively binds to the target material is attached, and a second unit which is disposed at another portion of the platform and detects a target material included in the sample by a different reaction from the reaction conducted in the first unit.
US10252263B2	Microfluidic devices and methods of manufacture and use Microfluidic devices are provided for conducting fluid assays, for example biological assays, that have the ability to move fluids through multiple channels and pathways in a compact, efficient, and low cost manner. Discrete flow detection elements, preferably extremely short hollow flow elements, with length preferably less than 700 micron, preferably less than 500 micron, and internal diameter preferably of between about 50+/−25 micron, are provided with capture agent, and are inserted into microfluidic channels by tweezer or vacuum pick-and-place motions at fixed positions in which they are efficiently exposed to fluids for conducting assays. Close-field electrostatic attraction is employed to define the position of the elements and enable ready withdrawal of the placing instruments. The microfluidic devices feature flow elements, channels, valves, and on-board pumps that are low cost to fabricate accurately, are minimally invasive to the fluid path and when implemented for the purpose, can produce multiplex assays on a single portable assay cartridge (chip) that have low coefficients of variation. Novel methods of construction, assembly and use of these features are presented, including co-valent bonding of selected regions of faces of surface-activatable bondable materials, such as PDMS to PDMS and PDMS to glass, while contiguous portions of one flexible sheet completes and seals flow channels, fixes the position of inserted analyte-detection elements in the channels, especially short hollow flow elements through which sample and reagent flow, and other portions form flexible valve membranes and diaphragms of pumps. A repeated make-and-break-contact manufacturing protocol prevents such bonding to interfere with moving the integral valve diaphragm portions from their valve seats defined by the opposed sheet member, which the flexible sheet material engages. Preparation of two subassemblies, each having a backing of relatively rigid material, followed by their assembly face-to-face in a permanent bond is shown. Hollow detection flow elements are shown fixed in channels, that provide by-pass flow paths of at least 50% of the flow capacity through the elements; in preferred implementations, as much as 100% or more. Metallized polyester film is shown to have numerous configurations and advantages in non-permanently bonded constructions. A method of preparing detection elements for an assay comprises batch coating detection elements, or hollow flow elements by mixing and picking and placing the elements in flow channels of a microfluidic device, capturing the flow elements by bonding two opposed layers while sealing the flow channels.
US10252261B2	Handling liquid samples Devices, systems and methods for making and handling liquid samples are disclosed.
US10252257B2	Ion exchange membrane The ion exchange membrane according to the present invention comprises a layer A comprising a fluorine-containing polymer having a sulfonic acid group and a layer B comprising a fluorine-containing polymer having a carboxylic acid group, wherein a ratio of an ion cluster diameter of the layer B after electrolysis under the following electrolysis conditions to the ion cluster diameter of the layer B before the electrolysis [(the ion cluster diameter of the layer B after the electrolysis)/(the ion cluster diameter of the layer B before the electrolysis)] is 0.83 to 0.95:(Electrolysis Conditions)in a zero-gap base electrolytic cell where the ion exchange membrane is disposed between an anode chamber to which a 3.5 N aqueous sodium chloride solution is supplied and a cathode chamber to which a 10.8 N aqueous sodium hydroxide solution is supplied, electrolysis is performed for 7 days under conditions having a temperature of 85° C. and a current density of 6 kA/m2.
US10252253B2	G-C3N4 film In order to provide g-C3N4 capable of being simply and easily handled, a g-C3N4 film is produced by heating, as a starting material, a compound represented by X+mYm−, wherein X+ is a guanidium ion or the like ion, and Ym− is an anion, to vaporize the compound or its reactant, and depositing the compound or the reactant over a surface of a base material heated, the surface carrying negative electric charges or having π electrons, so that the compound or the reactant is polymerized on the base material to generate g-C3N4.
US10252252B2	Zeolite promoted V/TiW catalysts Provided is a catalyst composition for treating exhaust gas comprising a blend of a first component and second component, wherein the first component is an aluminosilicate or ferrosilicate molecular sieve component wherein the molecular sieve is either in H+ form or is ion exchanged with one or more transition metals, and the second component is a vanadium oxide supported on a metal oxide support selected from alumina, titania, zirconia, cella, silica, and combinations thereof. Also provided are methods, systems, and catalytic articles incorporating or utilizing such catalyst blends.
US10252249B2	Composition and a process for preparation of attrition resistant cracking catalyst suitable for enhancing light olefins The present invention relates to a composition of attrition resistant attrition resistant catalyst particularly for FCC catalyst additives such as ZSM-5, bottom cracking additive/residue upgradation additive and GSR additive comprising aluminum phosphate binder wherein said binder comprising of 1.5 to 2.9 moles equivalent of monobasic acid for each mole of mono-aluminum phosphate (MAP). Further, the aluminum phosphate binder is added to the catalyst additive to ensure effective binding of catalyst as well as preserving catalyst activity with high selectivity towards light olefins including LPG.
US10252248B2	Transition metal oxide-containing cerium dioxide particles The oxide-containing particles (transition metal oxide-containing cerium dioxide particle) exert a catalyst performance, and include at least an iron oxide containing an iron component and a manganese oxide containing a manganese component on a surface of each of cerium dioxide particles, wherein the iron oxide and manganese oxide have smaller particle diameters than that of the cerium dioxide particles, and the content rate of the iron oxide and the manganese oxide is within the range of from 15.0% by mass to 35.0% by mass.
US10252247B2	Catalyst to attain low sulfur gasoline This invention relates to a hydrodesulfurization catalyst, a method for preparing the catalyst, and a method for the preparation of low sulfur gasoline fuel with minimal loss of RON. The catalyst particles include a group VIB metal and a support material having relatively high surface area, and optionally includes one or more group VIIIB metal. The method for preparing the catalyst allows for greater loading of the active metal species on the surface of the support material under aqueous reaction conditions.
US10252243B2	Activation of waste metal oxide as an oxygen carrier for chemical looping combustion applications A process for producing black powder oxygen carriers for use in a chemical looping combustion unit includes the steps of: (a) removing and collecting the black powder waste material that was formed in a gas pipeline; (b) pre-treating the collected black powder to adjust its spherical shape to avoid attrition and fines production; and (c) activating the black powder to increase its reactivity rate and produce the black powder oxygen carrier that is suitable for use in the chemical looping combustion process as an oxygen carrier.
US10252242B2	Alkali-promoted activated alumina adsorbent An adsorbent for removing CO2 from a gas mixture, the adsorbent comprising alumina and a carbonate compound where the carbonate to alumina IR absorbance intensity ratio is reduced by washing the adsorbent with water. The disclosure also describes a method of making adsorbent particles, process for removing CO2 from a gas mixture using the adsorbent, and an adsorption unit using the adsorbent.
US10252241B1	Spring tube type flexible micro chemical reactor The present invention provides a spring tube type flexible micro chemical reactor. It comprises a reactor body, a thermal control device, and a gas generating device. The spring tube type flexible micro chemical reactor enhances the heat and mass transfer using the scroll spring tube, which is able to achieve accurate mixing and dynamic adjustment of the heat and mass transfer and is able to effectively solve the problems of blocking of channels by solid reactant, the poor portability of the reaction, etc.
US10252238B2	Apparatus for producing pulverulent poly(meth)acrylate An apparatus for producing pulverulent poly(meth)acrylate in a reactor for droplet polymerization having an apparatus for dropletization of a monomer solution for the production of the poly(meth)acrylate having holes through which the monomer solution is introduced, an addition point for a gas above the apparatus for dropletization, at least one gas withdrawal point on the circumference of the reactor and a fluidized bed, and above the gas withdrawal point the reactor has a region having a constant hydraulic internal diameter and below the gas withdrawal point the reactor has a hydraulic internal diameter that steadily decreases. The reactor has a heating means in the region having a steadily decreasing hydraulic internal diameter.
US10252237B2	Sustained super-saturations for condensational growth of particles An apparatus and method for creating enlarged particles in a flow. The apparatus includes a coiled tube having a tube diameter and a coil diameter, the tube having an input receiving the flow and an output, the tube having a length between the input and the output. A heater heats a first portion of the tube along a first, longitudinal portion of the tube, and a cooler cools a second, longitudinal portion of the tube along at least a second portion of the tube. The method includes heating a first portion of the tube along a first longitudinal portion of the tube, and simultaneously cooling a second portion of the tube along at least a second longitudinal portion of the tube. While heating and cooling, the method includes introducing a flow into an interior of the tube at an input, the flow moving the output.
US10252232B2	Method for producing particles A method for efficiently producing fine particles in a complex state from a plurality of raw material components is provided. The method includes spraying a good solvent solution made from a good solvent and the plurality of raw material components dissolved in the good solvent into a poor solvent having a temperature of at least 165° C. higher than the boiling point of the good solvent and evaporating off the good solvent and precipitating a plurality of fine particles.
US10252230B2	Tinting machine and method for dispensing colorant into a paint container with base paint A tinting machine (1) comprising one or more dispenser heads for dispensing colorant into a paint container (3), the one or more dispenser heads comprising a fluid outlet (16) for discharging the colorant into the paint container (3), an internal chamber (19) opening in the fluid outlet, and a piston (25) that is longitudinally and movably arranged inside the internal chamber. An outer side surface of the piston and the inner surface of the internal chamber define an annular space (29) and the piston comprises a circumventional protrusion (26) defining a constriction (28) in the annular space. By supplying cleaning fluid to the internal chamber and moving the piston between a first and a second position, the internal chamber can be cleaned from residual colorant with a small amount of cleaning fluid. The invention further relates to a method for dispensing one or more colorants into a paint container using such tinting machine.
US10252224B2	Hydrophobic-oleophilic hollow fiber composite membrane and preparing method thereof The present invention discloses a hydrophobic-oleophilic and hollow fiber composite membrane and preparing method thereof. A preparing method includes preparing hollow tubular braids by two-dimensional braided technique using polyester filaments, wherein the hollow tubular braids are used as the reinforcements. The method further includes mixing polyvinylidene fluoride, hydrophobic pore-forming agent, and the rest of solvent to prepare a casting solution of surface separation layer. The method further includes pre-treatment processing of the reinforcements; and coating the casting solution of surface separation layer on the outer surface of the processed reinforcements through a spinning spinneret to form a primary membrane. The reinforcements are replaced by the primary after post-processing, and repeating the coating process.
US10252223B2	Methods for manufacturing ion exchange membranes To make membranes, a plurality of membrane substrates are each wetted with a curable liquid mixture, arranged in a stack such that every pair of substrates are separated by at least one film, and moved simultaneously through a common curing region. Each wetted substrate sheet may be sandwiched between two films. After curing, the stack comprises two or more membranes with each pair of membranes separated by a film. An apparatus for making membranes comprises at least two substrate feeding devices, at least one film feeding device, one or more chemical wetting devices, a curing region, optionally, a stack separating region, and, optionally, a membrane binding or fusing region. Membrane production rate may be increased while the curing energy required per unit area of membrane is decreased. The method can make, for example, ion exchange membranes.
US10252222B2	Hollow fiber type semipermeable membrane, method for manufacturing the same, module, and water treatment method A hollow fiber type semipermeable membrane which achieves both water permeability and selectivity in high level and performs efficient treatment using small membrane area utilizing the concentration difference from high concentration liquid having high osmotic pressure. The hollow fiber type semipermeable membrane is characterized in that, when an aqueous solution of 25° C. having NaCl concentration of 35 g/L and pressure of 1.0 MPa is flown into an outer side of the hollow fiber type semipermeable membrane having length of about 70 cm while freshwater of 25° C. having NaCl concentration of 0 g/L is flown into an inner side of one open end of the hollow fiber type semipermeable membrane and discharged from another open end at 10 kPa or less, the permeation flow rate is 30 to 70 L/m2/day. An inner diameter thereof is 50 to 200 μm; and the hollow ratio thereof is 24 to 42%.
US10252220B2	Porous asymmetric polyphenylene ether membranes and associated separation modules and methods A porous asymmetric membrane comprises a hydrophobic polymer comprising a poly(phenylene ether) or poly(phenylene ether) copolymer; and a polymer additive. A separation module can be fabricated from the porous asymmetric membrane. A method of forming the porous asymmetric membrane comprises: dissolving a hydrophobic polymer comprising a poly(phenylene ether) or poly(phenylene ether) copolymer and, a polymer additive in a water-miscible polar aprotic solvent to form a porous asymmetric membrane-forming composition; and phase-inverting the porous asymmetric membrane forming-composition in a first non-solvent composition to form the porous asymmetric membrane. The polymer additive comprises hydrophilic functional groups, copolymerized hydrophilic monomers, or blocks of hydrophilic monomer repeat units. For example, the polymer additive can comprise a hydrophilic polymer or amphiphilic polymer. The porous asymmetric membrane can be a flat membrane or hollow fiber.
US10252216B2	Reduction of amine emissions from an aqueous amine carbon dioxide capture system using charged colloidal gas aphrons The present invention includes a system and process to reduce amine mist emissions (or MEA) from carbon capture systems using colloidal gas aphrons (CGA), and includes a method for separating and recovering an amine solvent (e.g., in the form of entrained droplets/mist and/or fine aerosol particles) from a carbon dioxide scrubbed flue gas stream exiting a carbon capture system (e.g., oil-fired power plants, coal-fired power plants, and/or natural gas combined cycle plants).
US10252213B2	Dehumidification device Provided is a dehumidification apparatus with good energy efficiency. A moisture absorbing material (polymeric moisture absorbing material 24), which absorbs moisture and swells at a temperature not higher than a predetermined temperature sensitive point, while shrinking and releasing condensed water at a temperature higher than the temperature sensitive point as a result of phase transition, is formed so as to be divided into a plurality of segments which are made apart from each other during dehydration. A rotation motor (21) is used to move the moisture absorbing material (polymeric moisture absorbing material 24) between a moisture absorption region (14a) and a dehydration region (14b). In the dehydration region (14b), the moisture absorbing material (polymeric moisture absorbing material 24) is heated by the heater (25).
US10252212B2	Moisture resistant molecular sieve beds An air separation unit for an OBOGS includes a housing having an inlet for receiving a wet inlet air and an outlet for outputting a dry product gas. The housing includes an outer side wall and annular walls defining a series of concentric annular chambers. A first annular chamber is coupled to the inlet and includes a desiccant material to receive the wet inlet air and output a dried air. An unfilled second annular chamber is coupled to the first annular chamber. A third annular chamber is coupled to the second annular chamber at a first end and the outlet at a second end. The third annular chamber receives air separation material to selectively remove unwanted constituents from the dried air and output the dry product gas. A tap may be coupled to the second annular chamber so that dried air may be removed from the housing.
US10252211B2	Purification process A process for removing halogen compounds, particularly chlorine compounds, from a process fluid, includes the steps of (i) passing a process fluid containing hydrogen halide over a first sorbent to remove hydrogen halide and generate a hydrogen halide depleted process fluid and then, (ii) passing the hydrogen halide depleted process fluid over a second different sorbent to remove organic halide compounds therefrom. A purification system suitable for removing hydrogen halide and organic halide compounds from process fluids is also described.
US10252209B2	Nanofiber sheet and method of producing the sheet Provided is a nanofiber sheet that has a high mechanical strength, is excellent in durability, and has a high specific surface area. The nanofiber sheet includes: a plurality of nanofibers; and a bulk portion produced by bonding of the nanofibers, in which 7×10−3 portion/μm2 or more of the bulk portion satisfying the following formula is contained: 0.5πX2≤Y≤5 μm2 (1) where X represents a diameter (μm) of each of the nanofibers and Y represents an area (μm2) of an inscribed circle of the bulk portion when viewed from a surface.
US10252205B2	Air filter element assembly for a motor vehicle A filter element assembly includes a filter body and an auxiliary filter. The filter body includes a sidewall around a hollow core. Further the filter body and auxiliary filter are both received and held on a support including a base and a cage.
US10252203B2	Filter with engine integrity protection A filter system includes a designated filter element including a geometric projection thereon and a filter element housing including an opening keyed to the geometric projection. The opening comprises a recess, a channel or a slot and the recess, the channel, or the slot includes a rib. The geometric projection engages the opening when the designated filter element is installed in the filter element housing, and the filter element housing includes a filter housing body and a filter housing cover.
US10252200B2	Filter media including a filtration layer comprising synthetic fibers Filter media comprising a filtration layer comprising synthetic fibers (e.g., pleatable backer layer) and related components, systems, and methods associated herewith are provided. In some embodiments, the filtration layer comprising synthetic fibers may be a non-woven web comprising a blend of coarse and fine diameter fibers. The filtration layer comprising synthetic fibers may be designed to have desirable performance properties without compromising certain mechanical properties, such as the pleatability of the media. In some embodiments, a filter media, described herein, may comprise the filtration layer comprising synthetic fibers and an efficiency layer. Filter media, as described herein, may be particularly well-suited for applications that involve filtering air, though the media may also be used in other applications.
US10252197B2	Filter assembly A filter assembly includes a manifold with a base and a support ring. The support ring is received within the base such that the support ring is rotatable relative to the base. A housing of the filter cartridge has an interface positioned at an outer surface of the housing. The interface is configured to engage with a post of the support ring in order to mount the filter cartridge to the manifold.
US10252195B2	Screen for hydraulic fluid The invention relates to a high-pressure hydraulic fluid screening element (1) for inserting into a hydraulic line or into a hydraulic connection of a hydraulic device, having an annular main body (2), which is aligned with respect to its axis of rotation (9) in a longitudinal direction (5). The outside diameter of the main body (2) is greater than its axial length. The inner cross section of the main body (2) is covered over by a screening region (3), which is provided with a multiplicity of apertures (4). In this case, the main body (2) and the screening region (3) are produced integrally by the powder injection-molding process.
US10252192B2	Filter medium, filtering device using filter medium, and filter medium manufacturing method A filter medium includes: a core yarn and a binder yarn twisted together, at least one of the core yarn or the binder yarn being weldable; and a filament yarn being fuzzy and weldable, the filament yarn being welded to at least one of the core yarn or the binder yarn while being placed between the core yarn and the binder yarn as twisted together. A filtering device for filtering a liquid to be treated with a filter medium layer includes the filter medium. A method of manufacturing the filter medium is also disclosed.
US10252188B2	Gas-liquid separation apparatus suitable for gas hydrate slurry A gas-liquid separation apparatus suitable for gas hydrate slurry, comprising an upper chamber, a middle chamber, and a lower chamber; a gas-phase outlet and a pressurizing unit are disposed in a top of the upper chamber, the middle chamber is provided with a material inlet and a wire mesh demister, and the lower chamber is provided with a liquid-phase outlet and a plurality of deflector baffles. The arrangement of divided chambers can reduce the degree of hydrate dissociation in the slurry (i.e., loss of the sought gas) and improve the separation efficiency. With the pressurizing unit, it facilitates the setting of the required pressure for gas-liquid separation without introducing a pressure maintaining valve in the subsequent separation process, prevents the hydrate in the slurry from dissociating in the apparatus, and allows rapid separation between the slurry and the gas.
US10252186B2	Automated solid phase extraction In a solid phase extraction (SPE) apparatus, a cartridge housing tray houses a plurality of SPE cartridges. A liquid loading assembly applies liquid samples and SPE solutions into the plurality of cartridges. A liquid drawing assembly forces the liquid samples and the SPE solutions once they are applied to pass through the plurality of the SPE cartridges.
US10252185B2	Method and apparatus for reaction chromatography An apparatus for reaction chromatography comprising: a chromatography column, the column having a fluid outlet for an eluate flow, wherein the fluid outlet is configured with two or more fluid ports, the two or more fluid ports comprising one or more reactant ports, wherein each reactant port is for connecting a reactant flow into the eluate flow to react with the eluate flow, and one or more product ports for receiving the reacted eluate flow; one or more reactant sources in fluid communication with the one or more reactant ports to provide the reactant flow; and one or more processing units in fluid communication with the one or more product ports to process the reacted eluate flow.
US10252183B2	Product management in biological conversion processes Improvements in biological conversion processes and associated apparatuses are disclosed for the generation of useful end products such as ethanol, through metabolic pathways of C1-fixing bacteria that utilize, as a nutrient, a C1-carbon source from a C1-containing substrate such as an industrial waste gas. Particular aspects of the disclosure relate to the downstream recovery of ethanol and/or isopropanol from bleed and permeate streams and more particularly to performing such recovery with improved efficiency that can advantageously reduce capital (e.g., equipment) and/or operating (e.g., utility) costs.
US10252180B2	Vaporizer for water pipe inlet The vaporizer assembly includes a nail sub-assembly formed of a high rate of heat transfer material and an adapter assembly formed of a lower rate of heat transfer material. The nail sub-assembly includes a bowl at an upper end and a shaft extending down from the bowl. The shaft has a hollow bore passing therethrough. The nail sub-assembly is preferably formed of a titanium alloy which can be heated to high temperatures without damage thereto. The adapter has a hollow core sized to receive the shaft of the nail therein. The nail is preferably threaded along with portions of the adapter to facilitate height adjustability of the nail relative to the adapter. Lower portions of the adapter are configured to mate with a water pipe inlet tube or other downstream vapor handling device.
US10252175B2	Article moveable between two positions and a method of combining two or more of the same There is provided an article, the article being moveable between a first position and a second position and biased to the second position. The article is retained in the first position until a predetermined condition is met, and wherein when said predetermined condition is met the article moves from the first position to the second position.
US10252170B2	Multi sourced point accumulation interactive game Gaming systems and methods for integrated computer-related and physical game play interactions between a game player, a physical game piece and an electronic device are defined. The physical game piece measures motion quantity and transmits motion data using a signal emitter when the signal emitter is actuated. The electronic device receives the transmitted signal, which a game application inputs along with user input. The game application uses the user input and the transmitted signal to tally game player score data in an accumulator.
US10252169B2	Providing leaderboard based upon in-game events An approach to facilitate providing leaderboards based upon in-game events within a game space. The leaderboards based on user progress to achieving one or more administrator defined objectives within the game space, where each objective requires the completion of one or more activities. An objective metric for the first user, indicating the first user's progress toward achieving the objective may be determined, based upon one or more activity metric values for the first user. The activity metric values providing an indication of the first user's progress toward completing activities required to be completed to achieve the objective, as defined by an administrator.
US10252168B1	System and method for granting in-game bonuses to a user Disclosed herein is technology for providing in-game bonuses to a user's in-game persona. The technology involves virtual items that provide quality-based bonuses and level based bonuses. The technology provides systems and methods for upgrading an item's level and enhancing the item's quality. If an upgrade or enhancement is unsuccessful, the item may be broken and the quality bonuses and level bonuses may be decreased until the item is repaired.
US10252167B2	Location graph adapted video games Technologies related to location graph adapted video games are generally described. In some examples, location graphs may be generated for received environment inputs, such as received three dimensional (3D) models of environments. Video games may be adapted to generated location graphs, such as by placing video game content at nodes of location graphs. Video game and/or user parameters may be accommodated when adapting video games to location graphs.
US10252164B2	Avatar teleport controller A game system has a server managing a game to a first platform comprising a head-mounted display (HMD) and a three-axis controller, where a movement of a first avatar is made by marking a position to move and teleporting the to the marked position, and managing the same game to a second platform comprising a pointer device and a display screen, where movement of a second avatar is by the pointer device at a pre-programmed rate. Procession of the game is displayed in the HMD from viewpoint of the first avatar, and in the display of the second platform from viewpoint of the second avatar, both avatars being displayed in both displays, and wherein the game server, executing the SW, constrains teleportation at the first platform only to positions within a radius that the second avatar is enabled to attain in a single continuous move at the pre-programmed rate.
US10252157B2	Control circuit of client-side game console for enabling multiple video game consoles to together emulate same standalone multiplayer video game through networking connection A control circuit of a client-side game console includes: a processor and a storage circuit for storing a computer program product. The processor is arranged to operably execute the computer program product to perform following operations: establishing networking connection between the client-side game console and a master-side game console; receiving client-side input values generated by a user control device of the client-side game console; transmitting the client-side input values to the master-side game console; receiving a target instruction and a pseudo clock indicator value transmitted from the mater-side game console; executing the target instruction in a client-side emulating environment based on the pseudo clock indicator value; and rendering an updated client-side game screen according to execution results of the target instruction and displaying the updated client-side game screen on a display device.
US10252151B2	Gyroscopic apparatuses and methods of using same A gyroscopic exercise apparatus, comprising: at least one control-moment gyroscope; at least one motion sensor for sensing movement of the apparatus; at least one spindle motor for providing rotation to a rotor of the gyroscope; and, at least one reversible motor for providing rotation to at least one gimbal of the gyroscope.
US10252150B1	Method and system for temporarily incentivizing user participation in a game space A system and method for temporarily altering the determination of gameplay metric values in a game space, and distributing awards based on the relative change in gameplay metric values during the temporary time.
US10252148B2	Dealing robot device with dual card shoes A dealing robot device with dual card shoes is provided in the present application. The dealing robot device comprises a machine robotic arm, an electric poker rack, a controller and dual card shoes. The controller sends a controlling instruction to regulate movements of the robotic arm or the electric poker rack with which operations such as dealing or recollecting poker cards is completed such that a time difference between two rounds of games played by two different groups of players is effectively saved by the dealing robot device with dual card shoes. Accordingly, the efficiency of an online reality poker game is promoted by the dealing robot device with dual card shoes in the present application.
US10252140B1	Activity metric calculation for wearable devices A wearable device described herein includes a housing and a mount configured to mount the housing to an external surface of a wearer. The wearable device further includes one or more sensors configured to measure at least one physiological parameter of the wearer. The wearable device may obtain an activity metric that is based on at least one physiological parameter of the wearer measured by the one or more sensors and demographical data specific to the wearer. In some examples, the wearable may be configured to calculate the activity metric or a preliminary activity metric and to indicate the activity metric and/or preliminary activity metric to the wearer. In some examples, the wearable device may transmit the physiological parameter measurement to an external device and receive an indication of the activity metric from the external device.
US10252134B2	Paddle link—real time paddling performance A method and system are disclosed using a position sensor for tracking a trajectory of a paddling instrument. Optionally the trajectory may be used for determining a paddling improvement strategy, for recognizing a stroke type, for coordinating a rowing team and/or for calculating a paddling force.
US10252129B2	Structure of accessory element for equipment of floorball training court and use of it for formation of floorball simulator The invention refers to the equipment of the training rink for floorball, manufacturing of exerciser structural element, applying concept of tennis racket stringing. Proposed design of subsidiary element for floorball rink arrangement characterized with that it is made as latticework formed by: two parallel end plates; several threaded rods as stiffening members; two elastic string structures disposed in two parallel planes, at that each of it presents one side of mentioned latticework and provided with: holes for fastening threaded rods which assure rigidity and load bearing capacity of the subsidiary element frame structure; holes for criss-cross stringing in two parallel planes and string fastening at mentioned end plates independently one from another.
US10252128B2	Ball throwing machine and method A ball throwing machine can include a hopper for receiving one or more balls and a ball delivery device. The ball delivery device can be used to throw or pitch a ball from the hopper to a user of the machine. The ball delivery device can include wheels to impart speed to the ball and a direction system to control the projection angle of the ball. The direction system can control at least one of the up and down angle and the side to side angle of the ball as it is thrown, among possibly other throwing parameters. A controller may be provided for controlling operation of the ball throwing machine.
US10252114B1	Graphene core for a golf ball with a soft cover A golf ball with a core comprising polybutadiene and graphene, and a soft cover is disclosed herein. The golf ball has a dual core with an outer core comprising polybutadiene and graphene. The soft cover is preferably composed of a highly neutralized polymer, a first ionomer, a second ionomer, and a paraloid impact modifier.
US10252110B2	Hand cover apparatus A hand cover apparatus with a tensioning mechanism that tensions a portion of the apparatus such that it is urged to retract to an open position, freeing a portion of the user's hand. Said system has one stationary piece and at least one additional piece that moves relative to it and can be triggered to free the hand by using only the hand to which it is mounted.
US10252104B2	Sports mat The invention relates to a sports mat which consists of a flexible material and has a longitudinal direction (L) and a transverse direction (Q) perpendicular thereto, comprising a rectangular mat longitudinal subarea (2) and a rectangular mat transverse subarea (3) which intersects the mat longitudinal subarea (2) forming a T shape, an extension of the mat longitudinal subarea (2) in the transverse direction (Q) along a leg section (6) of the T being not more than half the size than a longest transverse extension of the mat transverse subarea (Q).
US10252101B2	Exercise machine Described herein are embodiments of stationary exercise machines having reciprocating foot and/or hand members, such as foot pedals that move in a closed loop path. Some embodiments can include reciprocating foot pedals that cause a user's feet to move along a closed loop path that is substantially inclined, such that the foot motion simulates a climbing motion more than a flat walking or running motion. Some embodiments can further include reciprocating handles that are configured to move in coordination with the foot via a linkage to a crank wheel also coupled to the foot pedals. Variable resistance can be provided via a rotating air-resistance based mechanism, via a magnetism based mechanism, and/or via other mechanisms, one or more of which can be rapidly adjustable while the user is using the machine.
US10252098B2	Fine weight-adjustment device for free-weight fitness equipment The disclosure provides a device for fine weight adjustment of a host apparatus. The host apparatus can be a free weight or similar having a bar with a bar diameter. The device can have an annular or disc-shaped body. The annular body can have an inner disc perimeter defining a central aperture having a diameter substantially similar to the bar diameter of the host apparatus. The annular body can also have a slot extending through the annular body from an outer perimeter to the central aperture defining a first disc end and a second disc end separated by a slot width. The annular body can be formed of a material having an elasticity sufficient to allow axial flexibility that returns the annular body to its original shape after being deformed to fit around the bar of the host apparatus.
US10252097B1	Weighted article with quick fill and hammock dam closure An article (600) is provided which includes a body (500) having an interior volume (100), and hook (124) and loop (125) features which, when pressed closed in at least one locations (130, 131) location, creates a dynamic hammock dam (132) that retains a fill material (140) that has been inserted into the interior volume. The strength of the hammock dam increases with outward pressure (141) applied on the closure by the fill material. The article is preferably equipped with a large mouth opening (110) which allows rapid filling or emptying of the fill material from the internal volume.
US10252087B2	Hair darkening dye composition A hair darkening dye composition, comprises: 2-98 parts by weight of hair dye; 1-99 parts by weight of darkening agent; 2-98 parts by weight of crosslinking agent; 2-98 parts by weight of emulsifier; 2-98 parts by weight of dyeing auxiliaries; and 0.1-40 parts by weight of pH regulator. The darkening agent is selected from one or more of chitin, chitosan, gelatin, silicon oil and resin. The chitin, chitosan and gelatin have a relative molecular weight of less than 2.7×104, and the silicon oil and resin have a refractive index of less than 1.55.
US10252085B2	Apparatus, system and method for neurostimulation by high frequency ultrasound An apparatus, system, and method for neurostimulation by high frequency ultrasound. In one embodiment, an apparatus includes a pulse generator, an ultrasound transducer coupled to the pulse generator, and an implantable stimulator. The implantable stimulator may include a piezoelectric element configured to convert ultrasound signals from the ultrasound transducer into electrical signals, a rectifier configured to convert alternating current from the piezoelectric element to a monophasic current, a capacitor coupled to the rectifier, and a first electrode and a second electrode coupled to the rectifier and capacitor and configured to transmit the monophasic current to body tissue. In addition, the apparatus may include a current-limiting circuit configured to limit the amount of current transmitted to the body tissue.
US10252084B2	Optical water surface detector and method A device and method to be used in the calibration process for a linear accelerator (LINAC). The optical water surface detector device allows the accurate determine of the height of the water surface in a tank. The device housing includes a light source and a light receiver. The housing can also include a circuit board. The device is mounted on an arm attached to a vertical position mechanism mounted within the tank. The light source within the device is controlled by a main control unit which also receives signals from the receiver and determines the amount of light striking the receiver. The control unit also controls the position of the vertical position mechanism and thus the arm on which the device is mounted.
US10252083B2	Systems, methods, and devices for high-energy irradiation A high-energy radiation treatment system can comprise a laser-driven accelerator system, a patient monitoring system, and a control system. The laser-driven accelerator system, such as a laser-driven plasma accelerator or a laser-driven dielectric microstructure accelerator, can be constructed to irradiate a patient disposed on a patient support. The patient monitoring system can be configured to detect and track a location or movement of a treatment volume within the patient. The control system can be configured to control the laser-driven accelerator system responsively to the location or movement of the treatment volume. The system can also include a beam control system, which generates a magnetic field that can affect the radiation beam and/or secondary electrons produced by the irradiation beam. In some embodiments, the beam control system and the patient monitoring system can comprise a magnetic resonance imaging system.
US10252081B2	Apparatus and method using automatic generation of a base dose A control circuit forms a radiation therapy treatment plan by automatically generating a base dose that references dosing information from multiple sources (such as multiple information sources) and then using that base dose to optimize a radiation therapy treatment plan. That radiation therapy treatment plan is then used to administer radiation therapy to a patient. That automatically generated base dose can represent any or all of earlier radiation therapy treatments for the patient, a same fraction as a dose presently being optimized per the radiation therapy treatment plan, and future planned fractions for the patient.
US10252080B2	Display device and display system including first polarization layer formed over first display area and second polarization layer formed over second display area A display device and a display system are disclosed. In one aspect, the display device includes a pixel unit including a first display area and a second display area, a controller configured to control the pixel unit to display a first image in the first display area and a second image in the second display area, a first polarization layer formed over the first display area and having a first polarization direction, and a second polarization layer formed over the second display area and having a second polarization direction different from the first polarization direction. The second image includes a light therapy image or an image adjusted for color blindness.
US10252078B2	Ophthalmic phototherapy method Provided herein are ophthalmic phototherapy devices and associated phototherapy methods for promoting healing of damaged or diseased eye tissue. An ophthalmic phototherapy device includes a light emitting mechanism for transmitting light of at least one preselected wavelength to the eye tissue. An ophthalmic phototherapy method includes directing light of at least one wavelength for a selected period of time to a portion of damaged or diseased eye tissue, whereby the light transmitted to the damaged or diseased eye tissue stimulates cellular activity in the eye tissue to promote healing.
US10252075B2	Ocular therapy device The invention relates to an ocular therapy device having a radiation source emitting UV light and an optical imaging system disposed downstream of the radiation source for imaging a therapy beam coming from the radiation source in an ocular imaging plane, wherein an optical condenser unit is disposed downstream of the radiation source and comprising a diaphragm unit, an optical means for influencing a spatial energy distribution which can be associated with the therapy beam and is oriented along the therapy beam cross-section, and comprising an optical means for influencing a beam form, which can be associated with the therapy beam.
US10252072B2	System and method of generating high voltage variable frequency electromagnetic radiation In a high voltage, variable frequency radiation generation system, a carrier signal supplied to a primary coil of a transformer is varied, e.g., turned ON and OFF at variable frequencies. The ON duration and/or the average amplitude of the carrier signal may also be varied. Moreover, the carrier signal may be modulated using an audio signal. The parameters to control the variation of the carrier can be provided as a recipe via a software application. A server can provide different types of apps providing different control features. The server may also collect user characteristic data and recipe usage data, and may facilitate exchange of these data and may recommend recipes based on a particular user characteristic.
US10252065B2	Pulse generating system The present disclosure relates to a pulse generating system comprising a pulse generator for generating a pulse or pulses and a controller for controlling the pulse generating means, where the pulse generating system is capable to work in at least a regular mode and a safety mode, where in the regular mode the pulse generator and the controller are connected and where in the safety mode there is no connection between the pulse generator and the controller and where in the safety mode the pulse generator automatically switches to a baseline stimulation command.
US10252060B2	Methods and apparatus to stimulate the heart A method and apparatus for treatment of hypertension and heart failure by increasing secretion of endogenous atrial hormones by pacing of the heart. Pacing is done during the ventricular refractory period resulting in premature atrial contraction that does not result in ventricular contraction. Pacing results in the atrial wall stress, peripheral vasodilation, ANP secretion. Concomitant reduction of the heart rate is monitored and controlled as needed with backup pacing.
US10252059B2	Method and apparatus for guided optimization of spatio-temporal patterns of neurostimulation An example of a system for programming a neurostimulator may include a storage device and a pattern generator. The storage device may store a pattern library and one or more neuronal network models. The pattern library may include fields and waveforms of neuromodulation. The one or more neuronal network models may each be configured to allow for evaluating effects of one or more fields in combination with one or more waveforms in treating one or more indications for neuromodulation. The one or more neuronal network models may include a first pain model configured to allow for optimization of neurostimulation using paresthesia, the second pain model configured to allow optimization of neurostimulation using anatomy. The pattern generator may be configured to construct and approximately optimize a spatio-temporal pattern of neurostimulation and/or its building blocks using at least one or more of the first pain model or the second pain model.
US10252056B2	Method and apparatus for preventing or terminating epileptic seizures A method and apparatus for preventing or terminating seizures, by stimulating a brain with at least two implanted electrodes, each implanted in a different one of at least two regions of the brain, with a frequency to emulate and/or disrupt neuronal synchrony. Upon detecting a potential or actual seizure occurrence, the frequency is electrically applied to the brain upon the detection to preempt or terminate the potential or actual seizure occurrence.
US10252055B2	Target therapy delivery site selection In some examples of selecting a target therapy delivery site for treating a patient condition, a relatively high frequency electrical stimulation signal is delivered to at least two areas within a first region (e.g., an anterior nucleus of the thalamus) of a brain of a patient, and changes in brain activity (e.g., as indicated by bioelectrical brain signals) within a second region (e.g., a hippocampus) of the brain of the patient in response to the delivered stimulation are determined. The target therapy delivery site, an electrode combination, or both, may be selected based on the changes in brain activity.
US10252052B2	Methods relating to the use of remote ischemic conditioning The invention contemplates, inter alia, the use of remote ischemic conditioning in the treatment of a variety of disorders.
US10252051B2	Handheld facial massage and light therapy device One form of the device is a standard handpiece having a series of interchangeable treatment heads. The handpiece can accept cooperating treatment heads for twist-locking therein or by other engagement arrangement. The treatment heads may or may not have an internal motor assembly within them to create vibratory motion in the assembled device. The groups of possible treatment heads include LED-light-emitting heads, microcurrent-emitting heads, a treatment head having an abrasive or pebbled surface, as well as a bristle brush head. In another version, the handpiece and treatment head are integrated and not exchangeable. In this second version, a combination LED-light-emitting outer ring surrounds a central dual-lobe massage surface. The dual-lobe massage surface may be made from an inert material such as silicone, or it may be metallic in order to provide emission of therapeutic microcurrents.
US10252049B2	Method and device for acquiring physiological data during tissue stimulation procedure A method and system of providing therapy to a patient implanted with an array of electrodes is provided. A train of electrical stimulation pulses is conveyed within a stimulation timing channel between a group of the electrodes to stimulate neural tissue, thereby providing continuous therapy to the patient. Electrical parameter is sensed within a sensing timing channel using at least one of the electrodes, wherein the first stimulation timing channel and sensing timing channel are coordinated, such that the electrical parameter is sensed during the conveyance of the pulse train within time slots that do not temporally overlap any active phase of the stimulation pulses.
US10252043B2	Vaccination delivery system and method A device can be used for delivering a dose of a vaccine, a medicine, a medication, a drug, or a prescription. For example, this document describes a wearable vaccination device that plays an audible sound or a musical tune for distracting or entertaining a patient while an intradermal vaccine is delivered via the patient's skin. A control portion of the wearable vaccination device includes a processing unit, a rhythm producer that produces audible sounds to distract or entertain the patient, and an injection module that provides an intradermal injection using one or more microneedles.
US10252041B2	Pack for supplying carbon dioxide to skin and manufacturing method thereof The present invention provides a pack for supplying carbon dioxide to a skin, capable of storing carbonate and acid in an unreacted mixed state without being degenerated according to a change with the passage of long time and easily usable. The pack is formed by successively applying and drying an acid-coated layer and a carbonate-coated layer on one side surface of a non-woven fabric and by laminating a waterproof film on the other side surface thereof. Otherwise, the pack is formed by including a first non-woven fabric configured to have one side surface on which a carbonate-coated layer is formed; a second non-woven fabric configured to have one side surface on which an acid-coated layer is formed; and a waterproof film, wherein the first non-woven fabric and the second non-woven fabric are laminated such that the carbonate-coated layer and the acid-coated layer face each other, and the waterproof film is attached on one outer surface of the lamination.
US10252038B2	Fluid delivery device for the nasal cavity A device for delivering fluid to a nasal cavity comprises an elongated member comprising a hollow exterior cannula and a hollow interior cannula. The interior cannula is flexible, is at least partially housed within the exterior cannula, and comprises an inlet for intake of the fluid and at least one outlet for ejecting the fluid. The exterior cannula has outlets for ejecting the fluid which are positioned within the nasal cavity by inserting the distal end of the device through a given nostril. A portion of the device has a continuously curving centerline that divides the device into a first and second lateral section. At least one outlet is positioned in each of the first and second lateral sections. Rotation of the distal section of the interior cannula within the exterior cannula permits the ejection of fluid predominantly out of outlets on respective lateral sides of the outer cannula.
US10252035B2	Rotatable control handles for medical devices and methods of using rotatable control handles Rotatable control handles and methods of using rotatable control handles are described herein. An example embodiment of a rotatable control handle comprises a handle, a compressible member disposed within the handle, a cap attached to the handle, and a cannula rotatably attached between the handle and the cap. The handle comprises a first member and a second member that is releasably attachable to the first member.
US10252034B2	Self-anchoring catheters and methods of use Catheters for percutaneous applications are disclosed. The catheter according to example embodiments may comprise a substantially straight section, an anchoring section positioned proximal to the substantially straight section. The anchoring section can have a curvature for providing longitudinal traction with a tissue to anchor the catheter to the tissue and a pathway extending through the catheter for transporting fluids. The pathway may comprise a first section and a second section in fluid communication with each other, where the first section extends through the length of the straight section, and the second section extends through the anchoring section and has a curvature which mimics the curvature of the anchoring section.
US10252030B2	Handheld magnetic gun for guide wire manipulation A magnetic field device for directing a magnetic coupling source includes an electrical power source, a control module, a muzzle, and an electromagnet adjacent the muzzle and connected to the electrical power source. A magnetic sensor within the muzzle is adjacent to the electromagnet. A magnet loading chamber is adjacent to the electromagnet magnetic and opposite to the magnetic sensor. The magnet loading chamber is configured to accommodate one or more permanent magnets. A magnetic shield surrounds exterior surfaces of the electromagnet and magnet loading chamber. A user operable control device is electrically connected to the electromagnet and to the electrical power source. The control device regulates an amount of electric current from the electrical power source to the electromagnet. A magnet guidewire delivery system includes a guide wire having a magnetic element and a magnetic field device generating a magnetic field that couples with the magnetic element.
US10252028B2	Balloon catheter A balloon catheter includes a balloon and an inner shaft. The inner shaft includes a marker member arranged on an outer periphery of a coil body having a sparsely wound portion in which gaps are formed between adjacent windings of the wire of the coil body. A distal end part and a proximal end part of the marker member are arranged at a position facing a void formed within one of the gaps between the adjacent windings of the wire of the coil body. The inner shaft of the balloon catheter therefore will not buckle, preventing damage to the balloon by contact with the marker member when the balloon catheter is passed through the inside of a curved blood vessel.
US10252015B2	Breathing assistance apparatus In one embodiment, a nasal cannula is shaped to fit within a user's nares, where the nasal cannula includes at least one prong allowing high flow delivery of humidified gases and creates positive airway pressure in the patient's airway. The prongs have angled ends such that, in use, gases flowing through the prongs are directed to the user's nasal passages. The nasal cannula body is partially swivelling and preferably has a ball joint connector. In another embodiment the nasal cannula may have at least one flared end prong that preferably seals within a patient's nare.
US10252011B2	System and method for intra-pulmonary percussive ventilation integrated with a ventilator The present disclosure pertains to a ventilation therapy system configured to control a pressure or flow generator to apply an intra-pulmonary percussive ventilation therapy regime to a pressurized flow of breathable gas during baseline ventilation therapy. The ventilation therapy system is configured to automatically control the pressurized flow of breathable gas. The system may automatically control an extent of hyperinflation during IPPV in a subject. The system is configured such that therapy set points, alarm settings, and/or other factors are automatically adjusted during the application of IPPV relative to the set points and alarm settings during baseline ventilation therapy. In some embodiments, the system comprises one or more of a pressure or flow generator, a subject interface, one or more sensors, one or more processors, a user interface, electronic storage, and/or other components.
US10252009B2	Heat-curling polymeric needle for safe disposal A needle having shaft that forms a tip and a portion proximate to the tip that is formed from a shape memory polymer. The shaft of the needle may be programmed to curl from a straight configuration to a curved configuration upon triggering by heat, thereby moving the sharp tip and providing a non-stick needle for safe and easy disposal.
US10252004B2	Method and apparatus for delivery of therapeutic agents Methods and apparatus for the reproducible, consistent and efficacious delivery of a therapeutic agent to a patient. The invention comprises means for the controlled administration of the therapeutic agent through an orifice to the patient, a plurality of penetrating electrodes arranged with a predetermined spatial relationship relative to the orifice, and means for generating an electrical signal operatively connected to the electrodes.
US10251999B2	Catheter insertion device A catheter insertion device (10) includes a housing (12) with a base (14), a catheter (28), an introducer needle (30) and an actuator (26) mounted within the housing. The catheter (28) and needle (30) are coupled to the actuator (26) and movable between a first position where the catheter and needle are retracted within the housing and a second position where the catheter (28) and needle (30) extend from the housing, and where the needle retracts into the actuator when the catheter and needle reach the second position. A spring (90) is provided in the housing (12) or the actuator (26) where the spring (90) is released after deployment of the device to retract the needle (20) with respect to the catheter (28).
US10251998B2	Stem cell delivery system This document provides systems and methods that can be used for the practice of regenerative medicine. For example, this document provides devices and methods for injecting stem cell material into tissue, such as heart tissue.
US10251991B2	Apparatus for making extracorporeal blood circulation available The present invention relates to an apparatus for making extracorporeal blood circulation available, in particular a heart-lung machine, comprising a venous connection and an arterial connection, between which a blood reservoir, a blood pump and a bubble detector for the detection of air bubbles are provided, with, downstream of the bubble detector, an arterial line leading to the arterial connection via an arterial clamp and a bypass leading via a bypass clamp back into the blood reservoir which is connected to a pump extracting air from the blood reservoir. In addition, the present invention relates to a method of operating such an apparatus.
US10251990B2	System and method for processing, incubating, and/or selecting biological cells A method for automated processing of a cellular product comprising target substrate cells, the method comprising providing a separation apparatus configured to associate with a disposable sterile circuit comprising a separator in communication with the cellular product. The apparatus and disposable sterile circuit are configured to remove platelets from the cellular product to form a platelet-depleted cellular product, resuspend the platelet-depleted cellular product in media to form a resuspended platelet-depleted cellular product, receive an agent having an association with the target substrate cells of the resuspended platelet-depleted cellular product, incubate the agent with the target substrate cells over a period sufficient for the agent to bind with and/or enter the target substrate cells to form a first mixture comprising agent-target substrate cell complexes, unbound/unassociated agent, and non-target substrate cells, and remove unbound/unassociated agent to form a second mixture comprising the agent-target substrate cell complexes and non-target substrate cells.
US10251989B2	Compact pulmonary assist device for destination therapy The present invention relates generally to a pulmonary assist device comprising a housing having tapered inlets and outlets to distribute blood evenly over a fiber bundle. The fiber bundle has a relatively low packing density to prevent the formation of clots. The invention is adapted to be used with a pump or without a pump, in which the heart supplies the necessary blood flow. Moreover, the device can be used as a single module or as multiple modules arranged in parallel.
US10251983B2	Automatically switching different aspiration levels and/or pumps to an ocular probe Methods and apparatuses for automatically switching different aspiration levels to an ocular probe are disclosed herein. The probe may be a phacoemulsification probe. A first aspiration level, supplied by a first pump, may be applied to the probe simultaneously with ultrasonic energy. A second aspiration level, supplied by a second pump, may be automatically switched from the first aspiration level. Control feed back of the pumps may be varied according to set thresholds.
US10251982B2	Biocompatible, biomimetic ampholyte materials New ampholyte biomaterial compounds containing ampholyte moieties are synthesized and integrated into polymeric assemblies to provide hydrophilic polymers exhibiting improved biocompatibility, haemocompatibility, hydrophilicity non-thrombogenicity, anti-bacterial ability, and mechanical strength, as well as suitability as a drug delivery platform.
US10251981B2	Coating layer, coating solution, method for forming coating layer, and method for producing medical tool Provided is a coating layer including a reaction product of a diisocyanate compound (a) selected from the group consisting of aromatic diisocyanates, aliphatic diisocyanates, and alicyclic diisocyanates, a polyol (b), and a copolymer (c) having a functional group selected from the group consisting of carboxylic acid groups, carboxylic acid ester groups, and carboxylic acid anhydride groups. The coating layer exhibits sufficient lubricity in wet conditions and has excellent durability.
US10251975B2	Surface treatment process for implantable medical device A surface treatment process for an implantable medical device including a surface dielectric insulating layer, the process comprising the application of ions onto said dielectric insulating layer, the ions being capable of forming an electrostatic charge and locally creating an electric field associated with at least part of the surface of said implantable medical device upon application of a liquid to said surface.
US10251971B2	Compositions and methods for multipurpose disinfection and sterilization solutions The present disclosure discloses compositions and methods for multipurpose disinfection and sterilization solutions broadly effective against multiple microbial pathogens. The present disclosure demonstrates broad spectrum antimicrobial activity against environmental and pathogenic amoeba, bacterial spores, vegetative bacteria, fungi, rickettsia, viruses, parasites and toxic microbial products. The multipurpose disinfection solutions of the present disclosure may be used alone or in combination for a variety of purposes, including disinfection of medical devices such as contact lenses, contact lens cases, surgical instruments, and dental instruments.
US10251968B2	Electronic scented candle and fragrance container An electronic scented candle is described that includes a flame piece, a shell including an installation chamber, a fragrance container that is removably positioned inside the installation chamber, a scent chamber, and a liquid suction channel positioned within the fragrance container. One end of the liquid suction channel protrudes from the fragrance container into the scent chamber and anther end of the liquid suction channel is positioned within the fragrance container to draw a fragrance material from the fragrance container to the scent chamber. A scent outlet in communication with the scent chamber allows scent from the chamber to reach an external environment of the electronic scented candle, and an air inlet in communication with the scent chamber directs air from the external environment to the scent chamber. A heating device heats the content of the scent chamber to allow rapid dissemination of the scent chamber into an external environment.
US10251962B2	Single-pair earphone sterilizer with germicidal light Apparatus and methods include a single-pair earphone sterilize with germicidal light. Embodiments include a housing and a germicidal light source. The apparatus may include circuitry, such as power, to support the germicidal light source and a divider to shield the circuitry from the germicidal light source. The apparatus may also include attachment portions to position and maintain earphones in a position relative to the germicidal light source.
US10251961B2	Cromolyn derivatives and related methods of imaging and treatment Novel cromolyn analogs useful as imaging agents for detecting atherosclerotic plaques and for treating atherosclerosis and Alzheimer's Disease, and methods of making the cromolyn analogs, are disclosed. The cromolyn analogs have the general formula: wherein: X is OH, C1-C6 alkoxyl; Y and Z are independently selected form a C1-C6 alkyl, C1-C6 alkoxyl, halogen, un-substituted or C1-C6 substituted amine, 18F, 19F, or H; and n is 1, 2, or 3; and wherein for structure (I), if n are both 1 and Y and Z are both H and X is OH.
US10251958B2	Nanoparticles for drug delivery comprising albumin having a polymer chain coupled thereto The invention provides a dispersion of assemblies. The assemblies comprise an albumin derivative comprising albumin having a polymer chain coupled thereto, wherein the assemblies comprise a core comprising the polymer chains and a shell comprising the albumin. A process for making the dispersion and methods of using the dispersion are also described.
US10251957B2	Composition for treating diabetes comprising long-acting insulin conjugate and long-acting insulinotropic peptide conjugate The present invention relates to a composition for the prevention or treatment of diabetes comprising a long-acting insulin conjugate and a long-acting insulinotropic peptide conjugate, and a therapeutic method for the treatment of diabetes, and more particularly, concurrent administration of the long-acting insulin conjugate and the long-acting insulinotropic peptide conjugate inhibits weight gain caused by insulin treatment, and vomiting and nausea caused by insulinotropic peptide treatment, and reduces the required dose of insulin, thereby remarkably improving drug compliance. Moreover, each of the long-acting insulin conjugate and the long-acting insulinotropic peptide conjugate of the present invention is prepared by linking insulin or insulinotropic peptide with an immunoglobulin Fc region via a non-peptidyl linker, thereby showing improved in-vivo duration of efficacy and stability.
US10251956B2	Methods of making pharmaceutical compositions with enhanced stability The present invention provides for a stabilized biodegradable polymeric composition useful as a controlled release delivery system for peptide agents. The compositions of the present invention comprise a) a beneficial salt of a luteinizing hormone releasing hormone (LHRH) analog formed with a strong acid that minimizes or prevents the interaction/reaction between the LHRH and the polymer in an organic solution; b) a biodegradable polymer; c) a pharmaceutically acceptable organic solvent; and d) optionally one or more excipients. The present invention also relates to a method of manufacturing and a method of use thereof.
US10251954B2	Hydrogel polymeric compositions and methods Some aspects of this disclosure relate to a method of treating an ophthalmic disease affecting an eye of a patient comprising forming a covalently-crosslinked hydrogel for controlled release of a therapeutic agent.
US10251950B2	Vaccine compositions for porcine epidemic diarrhea virus and porcine deltacoronavirus The present invention is directed to novel immunogenic compositions that protect swine from disease caused by porcine epidemic diarrhea virus (PEDV). The present invention is also directed to novel immunogenic compositions that protect swine from disease caused by porcine deltacoronavirus (PDCoV), alone or as combination vaccine to protect against PEDV. The compositions of the invention provide killed viruses whose effectiveness is enhanced by the selection of preferred adjuvants. Novel culture methods are also employed to increase reproducible yield of cultured viruses. Live vaccines are also provided from the Calaf14 PEDV isolate.
US10251947B2	Influenza vaccines The invention relates to a method for the treatment or prevention of an influenza virus infection in a subject, the method comprising administering to the subject a therapeutically effective amount of a gamma-irradiated influenza virus.
US10251942B2	Immunity-inducing agent An immunity-inducing agent comprising as an effective ingredient(s) a polypeptide(s) selected from the polypeptides: (a) a polypeptide consisting essentially of not less than 7 consecutive amino acids in any one of the amino acid sequences shown in SEQ ID NOs:2, 4, 6, 8, 10, 12 and 44 in SEQUENCE LISTING; (b) a polypeptide having a sequence identity of not less than 90% with the polypeptide (a) and consisting essentially of not less than 7 amino acids; and (c) a polypeptide comprising the polypeptide (a) or (b) as a partial sequence thereof; which polypeptide(s) has/have an immunity-inducing activity/activities, or as an effective ingredient(s) a recombinant vector(s) which comprise(s) a polynucleotide(s) encoding the polypeptide(s) and is/are capable of expressing the polypeptide(s) in vivo, is useful as a therapeutic and/or prophylactic agent for cancer, and/or the like.
US10251941B2	Factor VIIa-polysialic acid conjugates having prolonged in vivo half-life The present invention relates to a proteinaceous construct comprising plasmatic or recombinant factor VIIa (FVIIa) or biologically active derivatives thereof, which are bound to a carbohydrate moiety comprising 1-4 sialic acid units, wherein the in vivo half-life of the proteinaceous construct is substantially prolonged in the blood of a mammal, as compared to the in vivo half-life of a FVIIa molecule not bound to a carbohydrate moiety. The invention also provides a method for controlling bleeding in a mammal having a bleeding disorder due to functional defects or deficiencies of FVIIa, FVIII, or FIX. The invention also provides a method for controlling bleeding in a mammal during surgery or trauma.
US10251940B2	Preparation comprising factor VIII and Von Willebrand factor peptides A composition comprising a complex of Factor VIII and one or more Von Willebrand Factor peptides, wherein the Von Willebrand Factor peptides comprise at least the amino acids 764 to 1035 and 1691 to 1905 of SEQ ID No. 1 but not amino acids 2255 to 2645 of SEQ ID No. 1.
US10251938B2	Angiopoietin-based interventions for treating cerebral malaria The present invention provides methods for treating, preventing or reducing the severity of cerebral malaria. The methods of the present invention comprise administering to a subject in need thereof a therapeutically effective amount of a pharmaceutical composition comprising a modified angiopoietin molecule such as AngF1-Fc-F1.
US10251936B2	EBV antigen specific T-cell receptor and use thereof The present invention relates to an EBV antigen specific T-cell receptor and the use thereof. Specifically, the present invention provides T cells specific for LMP1 of EBV using a T-cell receptor which is highly specific for specific epitopes derived from an EBV antigen, LMP1. In addition, the EBV antigen specific T-cell can be used in the prevention or treatment of EBV-associated diseases.
US10251932B2	Preparations containing amorphous emodepside The invention relates to preparations comprising amorphous emodepside in a polyvinylpyrrolidone matrix, pharmaceuticals comprising such preparations, and their use against endoparasites in animals or humans.
US10251927B2	Process to enhance the bioactivity of Ashwagandha extracts The invention relates to an extract of Ashwagandha that exhibit enhanced bioactivity and bioavailability comprising of enriched withanolide glycosides and saponins; with negligible amount of alkaloids, withanolide aglycones and oligosaccharides. The extract as disclosed prepared from root, stems, leaves and whole plant of Ashwagandha further shows improved immunomodulatory activity, anti-inflammatory activity, anti stress activity, antidiabetic activity and sleep quality. The disclosure also provides a method of improving bioactivity of withanolide glycosides even at lower doses, by the administration of an enteric coaled formulation of extract of Ashwagandha to humans. The enteric coaling protects the composition from hydrolysis in the acidic environment of the stomach to release the withanolide glycoside in neutral/alkaline pH in gastrointestinal tract (GIT) thus enhancing the absorption. Further the process of preparation of the extract of Ashwagandha enriched with withanolide glycosides and saponins are disclosed along with various formulations.
US10251924B2	Compositions containing myristica fragrans Compositions as nutritional supplements comprising extracts of Myristica fragrans for improving exercise performance and for promoting weight loss are disclosed. The compositions may contain, and be standardized to, myristicin and may be administered prior to physical exercise.
US10251923B2	Therapeutic uses of mastic gum fractions The invention relates to therapeutic uses of gum mastic, and compounds found therein including polymeric myrcene. More particularly, the invention relates to methods of treating impaired neurological function using compositions comprising polymeric myrcene.
US10251922B2	Newcastle disease viruses and uses thereof Described herein are chimeric Newcastle disease viruses engineered to express an agonist of a co-stimulatory signal of an immune cell and compositions comprising such viruses. Also described herein are chimeric Newcastle disease viruses engineered to express an antagonist of an inhibitory signal of an immune cell and compositions comprising such viruses. The chimeric Newcastle disease viruses and compositions are useful in the treatment of cancer. In addition, described herein are methods for treating cancer comprising administering Newcastle disease viruses in combination with an agonist of a co-stimulatory signal of an immune and/or an antagonist of an inhibitory signal of an immune cell.
US10251917B1	Methods and materials for treating tumors This document provides methods and materials for treating a mammal (e.g., a human) having one or more tumors. For example, embolic agents including an amnion tissue preparation (e.g., amnion coated embolic agents) that can be used in arterial embolization to reduce or eliminate blood flow in a blood vessel that supplies a tumor are provided.
US10251913B2	Use of whey protein micelles and polysaccharides for improving insulin profile The present invention relates to a composition comprising polysaccharides and whey protein micelles for use in the treatment or prevention of a disorder linked to an increase in plasma postprandial insulin in a subject. The invention relates also to the non-therapeutic use of a composition comprising polysaccharides and whey protein micelles to decrease plasma postprandial insulin concentration. A further aspect of the invention is a process for forming polysaccharide-whey protein micelle complexes.
US10251910B2	Sodium nitrite-containing pharmaceutical compositions Provided herein are pharmaceutically acceptable sodium nitrite and pharmaceutical compositions thereof. Also provided herein are methods for determining the total non-volatile organic carbon in a sodium nitrite-containing sample. Further provided herein are methods for producing pharmaceutically acceptable sodium nitrite. Still further provided herein are methods of treatment comprising the administration of pharmaceutically acceptable sodium nitrite.
US10251909B2	Potassium-magnesium citrate as a surrogate of the DASH diet in managing hypertension The present invention includes compositions and methods for using a single pharmaceutical preparation of KMgCit is a convenient surrogate or to support the DASH diet in lowering blood pressure among patients with essential hypertension. Support is provided by potassium, magnesium and alkali, which overcome the underlying physiological-biochemical disturbances of essential hypertension, such as salt sensitivity, insulin resistance, low urinary pH, low serum magnesium and renal leak of calcium. Positive effects of KMgCitrate disclosed in normal subjects and patients with stones, provides assurance that KMgCitrate should ameliorate the above physiological-biochemical disturbances and associated disorders in patients with essential hypertension.
US10251907B2	Oligodeoxy nucleotide for preparing drugs for inhibiting tumor growth and application thereof The present invention provides an oligodeoxy nucleotide for preparing drugs for inhibiting tumor growth and an application thereof. The core sequence of the oligodeoxy nucleotide is RGGGAHTTYCS, wherein R is G or A; H is A or C or T; Y is C or T; S is C or G. The oligodeoxy nucleotide above further comprises an antisense strand and a modified type thereof. The oligodeoxy nucleotide according to the present invention plays a role of inhibiting the tumor growth in vitro and vivo, and is expected to be used for preparing drugs for inhibiting tumor growth, with high specificity and high inhibition ratio.
US10251905B2	Tissue maintenance The invention provides a method of reducing damage to a tissue, organ or cell from surgical procedures comprising administering a composition comprising a potassium channel opener/agonist and/or an adenosine receptor agonist (eg. adenosine) together with a local anaesthetic (eg. lignocaine) when perfusing the organ.
US10251902B2	Pharmaceutical composition for treating or preventing neuropsychiatric disease, containing flavone-6-C-glucose derivatives as active ingredients The present invention provides a pharmaceutical composition or a food composition comprising, as active ingredients, flavone-6-C-glucose derivatives or galenical extracts containing flavone-6-C-glucose derivatives. The composition of the present invention shows a functional effect of effectively treating or preventing cognitive dysfunction disorders such as delirium, dementia or amnesia, stroke, palsy, attention disorders, anxiety disorders or sleep disorders.
US10251900B2	Methods for treating pulmonary non-tuberculous mycobacterial infections Provided herein are methods for treating a pulmonary infection in a patient in need thereof, for example, a nontuberculous mycobacterial pulmonary infection for at least one treatment cycle. The method comprises administering to the lungs of the patient a pharmaceutical composition comprising a liposomal complexed aminoglycoside comprising a lipid component comprising electrically neutral lipids and an aminoglycoside. Administration comprises aerosolizing the pharmaceutical composition to provide an aerosolized pharmaceutical composition comprising a mixture of free aminoglycoside and liposomal complexed aminoglycoside, and administering the aerosolized pharmaceutical composition via a nebulizer to the lungs of the patient. The methods provided herein result in a change from baseline on the semi-quantitative scale for mycobacterial culture for a treated patient, and/or NTM culture conversion to negative during or after the administration period.
US10251897B2	GLUT4 endocytosis inhibitor The present invention provides a therapeutic drug for diabetes containing 1,2-dioleoyl-sn-glycerol-3-phosphoethanolamine (DOPE) as an active ingredient, particularly a therapeutic drug for diabetes that exhibits a GLUT4 endocytosis suppressive action by suppressing activation of PKCα and the like.
US10251895B2	Topical compositions and methods for treating psoriasis Topical pharmaceutical compositions comprise a combination of a corticosteroid a retinoid; and methods for treating psoriasis with same.
US10251894B2	Anticonvulsant activity of steroids The present invention relates to methods of preventing, inhibiting, delaying, and/or mitigating seizures by administration of a steroid, e.g., a neurosteroid, e.g., allopregnanolone.
US10251893B2	N-(hetero)aryl, 2-(hetero)aryl-substituted acetamides for use as Wnt signaling modulators The present invention relates to methods for modulating the Wnt signaling pathway using compounds of Formula (1), wherein A1, Y and Z all represent rings.
US10251889B2	Substituted pyrazolo[1,5-a]pyrimidine compounds as Trk kinase inhibitors Compounds of Formula I: and salts thereof in which R1, R2, R3, R4, X, Y and n have the meanings given in the specification, are inhibitors of Trk kinases and are useful in the treatment of diseases which can be treated with a Trk kinase inhibitor such as pain, cancer, inflammation, neurodegenerative diseases and certain infectious diseases.
US10251887B2	Methods and compositions to reduce oxidative stress The invention relates to therapeutic applications for compositions that reduce the level of oxidative stress on cells in vivo or in vitro. The invention describes methods for improving the therapeutic properties of stem cells. The invention also provides combination therapies that are useful to balance the oxidative microenvironment of cells in vivo or in vitro.
US10251885B2	Azole antifungal compositions The present invention relates generally to antifugal compositions. In an embodiment, the antifungal compositions are effective for application to nails and surrounding skin, and comprise at least one volatile solvent, at least one film forming substance, and at least one pyrimidone derivative of formula I, such as albaconazole. These compositions are capable of treating an infection caused by fungi, such as onychomychosis.
US10251876B2	Method for treating tumour, pharmaceutical composition and medicinal kit The present invention provides 1-[[[4-(4-fluoro-2-methyl-1H-indol-5-yl)oxy-6-methoxyquinolin-7-yl]oxy]methyl]cyclopro-pylamine used for combating a tumor. Specially, the present invention refers to method for treating tumor, pharmaceutical composition and medicinal kit related to the described compound. Administrating the compound with a suitable dosage regimen can not only make the patient's plasma concentration maintain the level of 100 ng/ml or lower, but also achieve effects of treatments and obtain benefits for various tumours.
US10251873B2	Methods of treating fabry patients having renal impairment Provided are methods for treatment of Fabry disease in a patient having renal impairment and/or elevated proteinuria. Certain methods comprise administering to the patient about 100 to about 150 mg free base equivalent of migalastat or salt thereof at a frequency of once every other day. Certain methods also provide for the stabilization of renal function, reducing left ventricular mass index, reducing plasma globotriaosylsphingosine and/or increasing α-galactosidase A activity in the patient.
US10251872B2	Multisubstituted aromatic compounds as serine protease inhibitors There are provided inter alia multisubstituted aromatic compounds useful for the inhibition of kallikrein, which compounds include substituted pyrazolyl or substituted triazolyl. There are additionally provided pharmaceutical compositions. There are additionally provided methods of treating and preventing certain diseases or disorders, which disease or disorder is amenable to treatment or prevention by the inhibition of kallikrein.
US10251870B2	Method for treating obesity, diabetes, cardiovascular and kidney diseases by regulating GPR30/GPER activity The current invention is in the field of molecular biology/pharmacology and provides methods of using compounds that modulate the effects of GPR30/GPER for treating obesity and diabetes (preferably agonists) as well as disease states and/or conditions that result from excessive formation of reactive oxygen species (preferably antagonists). These compounds may function as agonists and/or antagonists of the disclosed estrogen receptor and/or modulate the expression/upregulation of nox and nox-associated reactive oxygen species (ROS).
US10251868B2	Benzothiazolone compound The present invention provides a compound of formula (I) in free form or in pharmaceutically acceptable salt form a method for manufacturing the compound of the invention, and its therapeutic uses. The present invention further provides a combination of pharmacologically active agents and pharmaceutical compositions.
US10251865B2	Method of activating regulatory T cells with alpha-2B adrenergic receptor agonists Disclosed herein is a method of upregulating regulatory T-cells, and treating diseases that would benefit from such upregulation, by administering an alpha-2 receptor agonist.
US10251862B2	Cosmetic composition containing hydroxy pyranone derivative compound for promoting differentiation of adipocytes The present invention relates to a cosmetic composition containing a hydroxypyranone derivative compound as an active ingredient for promoting the differentiation of adipocytes. The composition according to the present invention has an effect of promoting the differentiation of adipocytes, and thus allows the differentiation of adipocyte in a skin layer, thereby increasing the skin volume or elasticity. Therefore, the composition of the present invention can be variously used as a cosmetic composition or a pharmaceutical composition in the field, such as skin damage.
US10251861B2	Methods for treating burn and scar injury using tocotrienol compositions The present invention provides methods to improve scar and burn outcome utilizing tocotrienols. In particular, various skin pathologies may be treated using the present methods. The present invention also provides methods to increase skin tissue concentrations of tocotrienols.
US10251856B2	Methods of treating neurodevelopmental diseases and disorders The present invention relates generally to methods for the treatment and/or prophylaxis of neurological diseases and disorders involving administration of trans 10-HDA. In particular, the methods of the present invention are useful in the treatment and/or prophylaxis of acquired or progressive neurodevelopmental disorders and conditions in mammals. More particularly, methods are taught herein for the treatment and/or prophylaxis of diseases and disorders such as autism spectrum disorders.
US10251853B2	Synergistic famciclovir and celecoxib combination therapy for functional somatic syndromes The present invention relates to methods of treating fibromyalgia, by administering a therapeutically-effective combination of an antiviral component and a COX-2 inhibitor component. The invention is further related to pharmaceutical compositions comprising a combination of a therapeutically-effective amount of the antiviral compound famciclovir and a therapeutically-effective amount of the COX-2 inhibitor celecoxib. The invention is also related to methods of treating functional somatic syndromes by administering a therapeutically-effective combination of famciclovir and celecoxib.
US10251849B2	Sublingual compositions including epinephrine nanoparticles The invention provides compositions including epinephrine nanoparticles and methods for therapeutic use of the compositions for the treatment of conditions responsive to epinephrine such as a cardiac event or an allergic reaction, particularly anaphylaxis. The epinephrine nanoparticles can be incorporated into orally-disintegrating and fast-disintegrating tablet pharmaceutical formulations and can significantly increase the sublingual bioavailability of epinephrine, and thereby reduce the epinephrine dose required. Additionally, the invention provides methods for fabrication of stabilized epinephrine nanoparticles for use in the described compositions.
US10251847B2	Polymorphic and amorphous forms of (R)-2-hydroxy-2-methyl-4-(2,4,5-trimethyl-3,6-dioxocyclohexa-1,4-dienyl)butanamide Disclosed herein are polymorphic and amorphous forms of anhydrate, hydrate, and solvates of (R)-2-hydroxy-2-methyl-4-(2,4,5-trimethyl-3,6-dioxocyclohexa-1,4-dienyl)butanamide and methods of using such compositions for treating or suppressing oxidative stress disorders, including mitochondrial disorders, impaired energy processing disorders, neurodegenerative diseases and diseases of aging. Further disclosed are methods of making such polymorphic and amorphous forms.
US10251839B2	Lipid vesicles derived from olive oil fatty acids Novel lipid vesicle compositions comprising lipids derived from olive oil fatty acids known as olivates, methods of their preparation, and methods of their use in cosmetics, food, dermatologics, and pharmaceuticals.
US10251838B2	Stereospecific lipids for locoregional therapy with long-term circulating stimuli-sensitive nanocarrier systems The invention relates to stereospecific lipids for the locoregional therapy with long-term circulating stimuli-sensitive nanocarrier systems. A preferred embodiment thereof is a thermosensitive liposome for treating tumors, especially urinary bladder tumors and other localized tumors.
US10251835B2	Cranial delivery of pharmaceuticals A method for rapid delivery of an active compound to innervate a cranial nerve of a subject. Also provided is a method for treating a disease or condition by topically applying a pharmaceutical composition to the face excluding the palpebral part of the eye, in an amount effective for treating the disease or condition.
US10251834B2	Transdermal drug administration device A transdermal drug administration device comprising a drug delivery element (10) defining a contact surface (12) for location, in use, against a patient's skin. The drug delivery element (10) includes a sustained-release pharmaceutical composition. The composition comprises a network of a carrier material having a high mechanical strength and an active pharmaceutical ingredient. The active pharmaceutical ingredient is co-formedly interspersed within pores in the solid, continuous network of the carrier material.
US10251830B2	Oxidizing composition for treating keratin fibres, comprising a phosphoric acid mineral salt, and processes therefor The present invention relates to an aqueous oxidizing composition for treating keratin fibers, comprising: —at least one oxidizing agent; —at least 40% by weight of at least one oil; —at least one phosphoric acid mineral salt; —the pH of the oxidizing composition being less than or equal to 5. The composition in accordance with the invention may be used for dyeing, bleaching or permanently reshaping keratin fibers. It produces ready-to-use compositions that give good dyeing, bleaching or permanent reshaping properties without degrading the keratin fibers and without impairing their cosmetic properties. Furthermore, the composition in accordance with the invention shows good stability over time, especially to storage at high temperatures, for example of about 45° C.
US10251826B2	Alkaline agent for lightening hair containing oxidants and special carboxylic acid esters The subject matter of the present disclosure includes agents for lightening keratin fibers, more particularly human hair, containing in a cosmetic carrier: (a) at least one carboxylic acid ester of the formula (I) (b) at least one peroxide compound, and (c) water, wherein the agent has a pH value in the range of from about 7.5 to about 12.5. A further subject matter of the present disclosure includes a kit-of-parts in which the aforementioned components exist packed separately in two agents (A) and (B).
US10251823B2	Oral care composition containing zinc salts and calcium carbonate The present invention provides an oral care composition comprising: (a) a first composition comprising a silica abrasive and a first zinc compound selected from zinc citrate, zinc chloride, zinc acetate, zinc lactate, zinc salicylate, zinc sulfate, and zinc nitrate; and (b) a second composition comprising a calcium carbonate abrasive; wherein the first composition and/or the second composition further comprises a second zinc compound selected from zinc oxide, zinc carbonate and zinc tartrate; and wherein the oral care composition optionally further comprises from 0.1 to 1.75 weight % of a tartar control agent, based on the total weight of the oral care composition.
US10251820B2	Topical composition comprising plant extracts The present invention relates to a topical composition comprising plant extracts. In particular, the present invention relates to a topical composition comprising plant extracts embedded in hydrophilic vesicles (niosomes), preferably having a size smaller than 500 nm, and at least one topically acceptable excipient.
US10251818B2	Feed-fortify enteral feeding and related methods therefor A pump set for use with a pumping apparatus to deliver nutrition to an infant is disclosed. The pump set can have a first container configured to receiving breast milk; a second container configured to receive fortifier; tubing extending from the first container and from the second container; and a valve mechanism connected to the first and second containers by the tubing and configured to selectively pass liquid from the first container and the second container.
US10251813B2	Flexibly mounted cartridge alignment collar for drug delivery device An alignment assembly for a cartridge interface of a drug delivery device is disclosed. The assembly optionally includes a coupling for opening fluid communication between the cartridge and the delivery device. For example, the coupling optionally includes a cannula insertable through a septum of the cartridge. The assembly may include a guide for positioning the cartridge and/or an access channel thereof within a first precision of a loaded position. The assembly optionally includes a cartridge engagement fitting (for example a gripping expander sleeve collar) attached to the coupling. Optionally when the cartridge is engaged to the fitting, the coupling is retained in connection with the access channel to within a second precision. The second precision is optionally higher than the first precision. In some embodiments one or more compliant supports movably retain the fitting oriented to engage the cartridge when the access channel is in the loaded position.
US10251809B2	Device for the treatment of sleep apnea syndrome in a patient by kinesthetic stimulation A device for treating sleep apnea in a patient through stimulation. The device includes a generator configured to produce stimulation pulses, a stimulator that receives the stimulation pulses produced by the generator and delivers stimulation to the patient, and a controller. The controller is configured to determine a sleep state of the patient, adaptively control the generator based on the sleep state where the sleep state includes a plurality of sleep stages, and modulate a stimulation energy of the stimulation pulses produced by the generator based on the sleep stage of the patient.
US10251806B2	Collapsible rolling walker A collapsible rolling walker that readily collapses for storage and/or transportation and that readily deploys for use.
US10251805B2	Control system and device for patient assist Systems and methods for use with haptic devices. A control system for haptic devices determines a first course of action based on a user's motion. Prior to implementing the first course of action, the control system determines if the first course of action would lead to instability in the haptic device which could cause an unsafe situation such as failure of its components. If the first course of action would lead to instability, the control device determines a second course of action that would not lead to instability and implements this second course of action. To assist in this second course of action and to prevent potential oscillation in the haptic device, the control system also selectively dampens a projected action of the haptic device. A haptic device using such a control system is also disclosed.
US10251800B2	Lifting device A lifting device, configured to attach to a lifting head and sling to move a disabled person from one location to another including a support column, a first arm, a second arm, and a friction brake. The support column includes an axis and is configured to attach between two stationary surfaces. The first arm is fixedly connected to the support column. The second arm is pivotally connected to the first arm at a pivot joint. The second arm is configured to connect to the lifting head. The support column and first arm are configured to rotate around the axis, and the second arm is configured to pivot around the pivot joint such that the second arm second end rotates three hundred and sixty degrees around the axis.

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