Document Document Title
US10240086B2 Garnet material, method for its manufacturing and radiation-emitting component comprising the garnet material
A radiation-emitting component comprising a ceramic material, comprising a garnet having the composition represented by the formula A3-xB5O12:Dx and a barium-containing oxide. In the garnet A3-xB5O12:Dx, A is selected from lutetium, yttrium, gadolinium, terbium, scandium, another rare earth metal or mixtures thereof. B is selected from aluminum, scandium, gallium, indium, boron or mixtures thereof. D is at least one dopant selected from chromium, manganese and rare earth metals, particularly cerium, praseodymium or gadolinium. The dopant is present with x is 0≤x≤2.
US10240085B2 Thin film and organic light-emitting device including the same
A thin film including a combination of a donor compound and an acceptor compound, and a phosphorescent dopant, wherein the donor compound and the acceptor compound form an exciplex having characteristics described in the specification.
US10240083B2 Thickening of fluids
An aqueous fluid, possibly a wellbore fracturing fluid, comprises an aqueous solution or dispersion of a first polymer, which may be polysaccharide, as a thickener and a cross linking agent to enhance the viscosity of the fluid by crosslinking the first polymer, wherein the crosslinking agent is a second polymer comprising at least one polymer chain with phenyl boronate groups distributed along the polymer chain and the phenyl boronic acid groups have nitrogen attached to the phenyl group at a position which is meta relative to the boronate group.
US10240079B2 Suspension for enhanced oil recovery
Embodiments of the present disclosure include suspensions for use in enhanced oil recovery, and methods of using the suspensions for recovering oil. Suspensions of the present disclosure include a nonionic surfactant that can dissolve in supercritical carbon dioxide, and a metal salt having a concentration of 200 to 1 parts-per-million.
US10240067B2 Curable polysiloxane compositions and slippery materials and coatings and articles made therefrom
The present teachings generally provide curable polysiloxane compositions including a base resin including a MQ vinyl siloxane. Articles of manufacture including the curable polysiloxane compositions and slippery coatings and materials also are provided. The compositions may be used to provide slippery, lubricious, or repellent materials and coatings and may provide anti-fouling function. The compositions can provide anti-fouling or foul-release function on open surfaces, internal surfaces, membranes; to provide pinning free or low contact angle hysteresis surfaces; to provide homogeneous interface to suppress nucleation; to provide a barrier layer such as anti-corrosion; to provide anti-stain, anti-smudge, anti-fingerprint, anti-soil function.
US10240064B2 Curable compositions and their use as coatings and footwear components
Curable compositions are provided comprising: (a) an isocyanate-functional prepolymer having a weight average molecular weight of 4000 to 15,000; (b) a curing agent comprising a mixture of polyamines, wherein at least one polyamine has an amine equivalent weight of 125 to 250; and (c) an abrasion resistant additive comprising organic and inorganic particles. The isocyanate-functional prepolymer is (i) a reaction product of a polyisocyanate and a polyamine having primary and/or secondary amino groups; and/or (ii) a reaction product of a polyisocyanate and a polyol. Upon application of the composition to a substrate as a coating and after curing to form a coated substrate, the coated substrate demonstrates a coating loss of less than 0.33 cm3 after being subjected to 1000 cycles of a TABER Abrasion Test using S-42 sandpaper strips and two 1000 gram weights. Coated substrates and footwear components prepared from the compositions are also disclosed.
US10240063B2 Light-shielding paint, light-shielding paint set, light-shielding film, optical element, method for producing light-shielding film, and method for producing optical element
A light-shielding paint includes an epoxy group-containing compound, an inorganic fine particle, a coloring agent, and an amine curing agent. The ratio (A′/A) of the mass (A′) of the amine curing agent to the active hydrogen equivalent (A) of the amine curing agent and the ratio (E′/E) of the mass (E′) of the epoxy group-containing compound to the epoxy equivalent (E) of the epoxy group-containing compound satisfy 0.1≤[(A′/A)/(E′/E)]≤0.45.
US10240061B2 Conductive polymer composite and substrate
The present invention provides a conductive polymer composite including: (A) a π-conjugated polymer, and (B) a dopant polymer which contains a repeating unit “a” shown by the following general formula (1) and has a weight-average molecular weight in the range of 1,000 to 500,000. There can be provided a conductive polymer composite that has excellent filterability and film-formability by spin coating, and also can form a conductive film having high transparency and flatness when the film is formed therefrom.
US10240058B2 Reactively assisted ink for printed electronic circuits
An ink contains particles containing metal that reacts during sintering to produce an electrically conductive line or area having a diffusivity that is less than the diffusivity of the metal before the reaction. Resulting electronic circuits therefore exhibit longer useful lives, compared to conventionally inkjet printed circuits.
US10240057B2 Conductive polymeric ink composition
Disclosed is a conductive polymeric ink composition, wherein pH of the ink composition can be adjusted to a desired neutral pH value while maintaining dispersibility of PEDOT:PSS (Poly(3,4-ethylenedioxythiophene):poly(styrenesulfonate)) used as a main component of the ink composition, thereby solving problems due to strong acidity, including a reduction in the lifetime of devices. Furthermore, a transparent conductive polymer thin film formed from the ink composition has low haze, low surface resistance and high conductivity, compared to thin films manufactured conventionally.
US10240052B2 Supercapacitor electrodes including graphenic carbon particles
Supercapacitor electrodes comprising active charge supporting particles, graphenic carbon particles, and a binder are disclosed. The active charge supporting particles may comprise activated carbon. The graphenic carbon particles may be thermally produced. The electrodes may further comprise electrically conductive carbon.
US10240044B2 Aqueous pigment dispersion and aqueous ink
The present invention provides an aqueous pigment dispersion including a pigment, an anionic group-containing organic polymer compound, and bio-nanofibers having an average diameter of 1 nm or more and 100 nm or less and an aspect ratio of 100 or more, and also provides an aqueous ink using the aqueous pigment dispersion. The bio-nanofibers are preferably cellulose nanofibers or chitosan nanofibers. The anionic group-containing organic polymer compound is preferably at least one selected from the group consisting of acrylic resins having anionic groups, polyurethane resins having anionic groups, and polysaccharide derivatives having anionic groups.
US10240043B2 Use for dyeing keratin fibres of a compound of azomethine type bearing two pyrazolopyridine units
The invention relates to a compound chosen from the compounds of formulae (I) and (II), the leucoforms thereof, the optical and geometrical isomers thereof and the tautomers thereof, and also the addition salts thereof with an acid or a base, and the solvates thereof. The invention also relates to the use of these particular compounds for dyeing keratin fibres.
US10240040B2 Method of making sulfur extended asphalt modified with crumb rubber
The present invention relates to asphalt compositions. The present invention provides for a sulfur rubber asphalt binder composition that includes a base asphalt having a softening point, elemental sulfur, and a crumb rubber material. The crumb rubber material is combined with the base asphalt and the elemental sulfur to create the sulfur rubber asphalt binder composition. The crumb rubber material is present in the sulfur rubber asphalt binder in an amount effective to increase the softening point as compared to the softening point of the base asphalt.
US10240039B2 Reinforced polycarbonate compositions
The disclosure concerns blended thermoplastic compositions comprising (a) from about 50 wt % to about 80 wt % of a polycarbonate component; (b) from greater than 0 wt % to about 12 wt % of an impact modifier component; (c) from about 10 wt % to about 40 wt % of a filler; and (d) from about 5 wt % to about 15 wt % of a flame retardant component comprising an oligomeric phosphate ester, wherein the oligomeric phosphate ester is a free flowing powder at 23° C.; wherein the blended thermoplastic composition has a ductility of 100% at 10° C. when measured by a Notched Izod Impact test performed according to ASTM D256; wherein the combined weight percent value of all components does not exceed 100 wt %; and wherein all weight percent values are based on the total weight of the composition.
US10240028B2 Halogen-free flame retardant polyamides composition
The present invention relates to halogen-free flame retardant compositions essentially comprising polyamide polymers (preferred is polyamide 6), at least a hypophosporous acid metallic salt (preferred is aluminum hypophosphite), at least a nitrogen based flame retardant agent (preferably selected among melamine condensation products such as melam, melem, melon or their mixtures, and melamine cyanurate), at least an organic polyhydric compound and optionally further conventional components. Such compositions are highly flame retardant.
US10240020B2 Process for producing porous materials
The present invention relates to a process for producing porous materials, which comprises providing a mixture comprising a composition (A) comprising components suitable to form an organic gel and a solvent mixture (B), reacting the components in the composition (A) in the presence of the solvent mixture (B) to form a gel and drying of the gel, wherein the solvent mixture (B) is a mixture of at least two solvents and the solvent mixture has a Hansen solubility parameter δH in the range of 3.0 to 5.0 MPa-1, determined using the parameter δH of each solvent of the solvent mixture (B). The invention further relates to the porous materials which can be obtained in this way and the use of the porous materials as thermal insulation material and in vacuum insulation panels.
US10240016B2 Method for a composite material impregnated with thermoplastic polymer, obtained from a prepolymer and a chain extender
A process for a composite material, including an assembly of one or more reinforcing fibers, impregnated with at least one thermoplastic polymer with a glass transition temperature Tg of less than or equal to 75° C. and a melting point of from 150° C. to less than 250° C. or a Tg of greater than 75° C., the process including: i) a step of impregnating said assembly in bulk melt form with at least one thermoplastic polymer, which is the product of polymerization by polyaddition reaction of a reactive precursor composition including: a) at least one prepolymer P(X)n of said thermoplastic polymer, and b) at least one chain extender, represented by Y-A-Y, ii) a step of cooling and obtaining a fibrous preimpregnate, and iii) a step of processing and final forming of said composite material.
US10240015B2 Modified polyphenylene ether, method for preparing same, polyphenylene ether resin composition, resin varnish, prepreg, metal-clad laminate and printed circuit board
A modified polyphenylene ether according to one aspect of the invention has an intrinsic viscosity, as measured in 25° C. methylene chloride, of from 0.03 to 0.12 dL/g, has on molecular ends thereof an average of 1.5 to 3 groups represented by formula (1) below per molecule, and includes not more than 5 mass % of a high-molecular-weight component having a molecular weight of 13,000 or more. In formula (1), R1 is a hydrogen atom or an alkyl group of 1 to 10 carbons, and R2 is an alkylene group of 1 to 10 carbons.
US10240012B2 Thermoplastic/thermoset grafted composites
Disclosed are thermoset/thermoplastic composites that include a thermoset component directly or indirectly bonded to a thermoplastic component via a crosslinked binding layer between the two. The crosslinked binding layer is bonded to the thermoplastic component via epoxy linkages and is either directly or indirectly bonded to the thermoset component via epoxy linkages. The composite can be a laminate and can provide a route for addition of a thermoplastic implant to a thermoset structure.
US10240010B2 Graphitic nanocomposites in solid state matrices and methods for making same
A composition and method for fabricating graphitic nanocomposites in solid state matrices is presented. The process for fabricating graphitic nanocomposites in solid state matrices may include selecting one or a mixture of specific graphitic nanomaterials. The graphitic nanomaterial(s) may be functionalizing with a moiety similar to the building blocks of the solid state matrices. The functionalized graphitic nanomaterials are mixed with the building blocks of the solid state matrices. The mixture may be cured, which causes in situ formation of the sol-gel solid state matrices that entraps and/or covalently links with the graphitic nanomaterials during the network growing process. This process allows the nanomaterials to be introduced into the matrices homogeneously without forming large aggregations.
US10240009B2 Composites of polyethylene and polylactic acid
A composite may include polylactic acid, polyethylene, and optionally a compatibilizer. The composite may be formed by combining the polylactic acid with the polyethylene. The composite may be formed into an extruded article.
US10240008B2 Thermoplastic vulcanizates and method of making the same
Described herein are thermoplastic vulcanizates comprising thermoplastic resin, an at least partially vulcanized rubber dispersed in the thermoplastic resin, and process oil. The process oil in the thermoplastic vulcanizate may be selected from extension oil, free oil, curative-in-oil, and/or combination thereof. At least a portion of the process oil in the thermoplastic vulcanizate is a low aromatic/sulfur content oil and has an aromatic content of less than 5 wt %, and a sulfur content of less than 0.03 wt %, based on the weight of that portion of the process oil. The thermoplastic vulcanizate exhibits improved gravimetric fogging properties.
US10240007B2 Shaped polylactide article and method of preparation
A method for preparing a shaped polylactide article including stereocomplex polylactide and to a shaped article obtainable by the method. In particular the method comprises melt mixing and solidifying poly-L-lactide (PLLA) and poly-D-lactide (PDLA) homopolymers in a weight ratio whereby one of the homopolymers is in excess, subsequently solid mixing the so obtained blend with additional homopolymer, and shaping the obtained solids mixture.
US10240003B2 Poly(aryl ether sulfone) composition and method of making
A poly(aryl ether sulfone) comprises units of formula (I): wherein Ar1 is a divalent C6-C15 aromatic group, Ar2 is a divalent C6-C15 aromatic group, Ar3 is a divalent C6-C15 aromatic group, and n is greater than 1; and a terminal group of formula (II) derived from a monofunctional phenoxide wherein is X is a hydrogen atom or an organic substituent having from 1 to 20 carbon atoms; wherein the poly(aryl ether sulfone) has a hydroxyl group content greater than 0 and less than 50 parts per million (ppm), based on the poly(aryl ether sulfone) weight, a glass transition temperature of 180 to 290° C., a weight average molecular weight of 20,000 to 100,000, a halogen content of greater than 0 and less than 3000 ppm based on the poly(aryl ether sulfone) weight. The poly(aryl ether sulfone) is free of methoxy groups.
US10239998B2 Moisture curable polymer systems based on a mixture of polysilylated polyethers
Low viscosity mixtures of polysilylated polyethers are described. The mixtures include a) 50 to 95 weight percent of one or more first polysilylated polyethers which are free of urea groups, have an average of two or more terminal hydrolysable silyl groups per molecule and have a molecular weight of 4,000 to 20,000 and 50 to 5 weight percent of one or more second polysilylated polyethers which are free of urea groups, have an average of 1.8 to 4 terminal hydrolysable silyl groups per molecule and have a molecular weight of 1000 to less than 400. The mixtures have surprisingly low viscosities, and are useful as curable components of adhesive, sealant, caulking and/or coating compositions.
US10239993B2 Branched polycarbonate resin and method for producing same
Provided is a branched polycarbonate resin, including a constituent unit represented by the general formula (I′).
US10239990B2 Isatin copolymers having intrinsic microporosity
A copolymer including a repeating unit represented by Formula I: wherein: L is a divalent hydrocarbon group comprising from 1 to 12 carbon atoms; and L′ is optional and when present is represented by Formula II: wherein: Y, Y′ and Y″ if present, are independently selected from: a carboxylic acid, sulfonic acid, phosphorous acid and phosphoric acid and their corresponding salt or ester; imino, amide, nitrile, hydrogen, hydroxyl and alkyl comprising from 1 to 6 carbon atoms; and A, A′ and A″ if present, are independently selected from an arylene moiety, with the proviso one or both Y″ and A″ may not be present.
US10239989B2 Curable composition
A curable composition that can be cured at low temperature in a short time regardless of the type of epoxy compound that is mixed therewith, and has a long pot life; an adhesive comprising said curable composition; a method for producing a fiber-reinforced composite material that uses the curable composition; and a fiber-reinforced composite material containing a matrix comprising the curable composition. A curing agent mixture composition that can be cured at low temperature and in a short time, and provides the curable composition with a long pot life. An epoxy compound (A) and an imidazole compound (B) are blended in with the curable composition. In addition, the imidazole compound (B) and at least one type of crosslinking agent (C) are blended in with the curing agent mixture composition.
US10239986B2 Highly elastic polyester modified urethane resin and clear coat composition containing same
Embodiments relate to a highly elastic polyester modified urethane resin and a clear coat composition containing the same, and more particularly, to a highly elastic polyester modified urethane resin having improved chipping resistance by introducing an aliphatic isocyanate and a caprolactone polyol to a polyester resin, and a clear coat composition including the polyester modified urethane resin as a main resin. For example, there is provided a polyester modified urethane resin, including polyester derived units obtained from an aliphatic polyalcohol and an aliphatic or alicyclic polyacid, caprolactone polyol derived units; and aliphatic diisocyanate derived units, as resin constituting units.
US10239982B2 Block polymers for sub-10 nm patterning
The present invention relates to a method for the synthesis and utilization of block copolymer can that form sub-10 nm lamella nanostructures. Such methods have many uses including multiple applications in the semiconductor industry including production of templates for nanoimprint lithography.
US10239978B2 Redox active colloidal particles for flow batteries
The invention provides a redox flow battery comprising a microporous or nanoporous size-exclusion membrane, wherein one cell of the battery contains a redox-active colloidal particle dispersed in a non-aqueous solvent. The redox flow battery provides enhanced ionic conductivity across the electrolyte separator and reduced redox-active species crossover, thereby improving the performance and enabling widespread utilization of the battery. Redox active colloidal particles (RACs) were prepared, analyzed, and were found to be highly effective redox species for use in redox flow batteries.
US10239976B2 Ethylene copolymers produced with single site catalyst
Embodiments of the invention described herein relate to a polyethylene polymer composition suitable for use in the manufacture of packaging articles, flexible films and/or sheets. In one embodiment, the copolymer comprises a polyethylene resin with density 0.918 g/cm3 to about 0.935 g/cm3, G′ at G″(500 Pa) value, as determined from Dynamic Mechanical Analysis at 190° C., of less than 40 Pa, Mz/Mw of greater than 2, CDBI50 of greater than 60. Other embodiments relate to polymer compositions with defined molecular characteristics and formulations suitable for use in the manufacture of articles including films, sheets, bags and pouches with improved creep resistance and high toughness and a good balance of film stiffness and processability in monolayer and/or multi-layer film structures.
US10239975B2 Silica-coated alumina activator-supports for metallocene catalyst compositions
Silica-coated alumina activator-supports, and catalyst compositions containing these activator-supports, are disclosed. Methods also are provided for preparing silica-coated alumina activator-supports, for preparing catalyst compositions, and for using the catalyst compositions to polymerize olefins.
US10239974B2 Ethylene-based polymers
The invention provides an ethylene-based polymer comprising the following properties: a) a ZSVR value from 1.2 to 2.6, b) a MWD from 1.5 to 2.8, and c) a tan delta (0.1 rad/s; 190 C) from 5.0 to 50.
US10239970B2 Method of producing fine particles of non-vinyl thermoplastic polymer
Fine polymer particles made by a method include producing an emulsion in a liquid prepared by dissolving and mixing a polymer A and a polymer B in organic solvents in which a solution phase composed primarily of the polymer A and a solution phase composed primarily of the polymer B are formed as separate phases, wherein the solvents in the two phases resulting from the phase separation are substantially identical to each other, and contacting the emulsion with a poor solvent for the polymer A to precipitate the polymer A, wherein the particles have a glass transition point of 150° C. or more and 400° C. or less, an average particle diameter of 1 μm or more to 100 μm or less, and a particle diameter distribution index of the particles is 2 or less, wherein the polymer A is nonvinyl type polymer.
US10239966B2 Block copolymer hydride and stretched film formed from same
The present invention is a hydrogenated block copolymer obtained by hydrogenating a block copolymer [C] that comprises polymer blocks [A] and polymer block [B], a ratio (wA:wB) of a weight fraction wA of the polymer blocks [A] and a weight fraction wB of the polymer block [B] in the block copolymer [C] being 45:55 to 65:35, a ratio (w[IB]:w[IIB]) of a weight fraction w[IB] of the repeating unit [I] derived from an aromatic vinyl compound and a weight fraction w[IIB] of the repeating unit [II] derived from a linear conjugated diene compound in the polymer block [B] being 40:60 to 55:45, 90% of more of unsaturated bonds included in the block copolymer [C] having been hydrogenated, a weight average molecular weight of 60,000 to 150,000, a low-temperature-side glass transition temperature [Tg1] of 0° C. or more and a high-temperature-side glass transition temperature [Tg2] of 135° C. or more, and a stretched film.
US10239963B2 Mixed salt suspension polymerization process and resins and catalysts produced thereof
This invention relates to no-salt and mixed salt suspension polymerization processes for water-soluble monomers and resins and relates to catalysts produced from the same.
US10239960B2 Phosphonated polysaccharides and gels and process for making same
Products and processes that are related to phosphonated polysaccharide compositions, including phosphonated polysaccharide gels, having a substituent degree of substitution with a lower limit of 0.02 and an upper limit of 3, and having a weight average molecular weight with an upper limit of 5,000,000 g/mole, as well as to oil field application or fracturing fluid compositions comprising such phosphonated polysaccharide compositions.
US10239959B2 Acylation process
The invention concerns a process for the manufacture of an acylated polymer composition comprising amylose and/or amylopectin, comprising a pre-treatment step in the presence of an acid and a hydroxycarboxylic acid, subsequent acylation and, preferably, a post-treatment step with an acid. The products obtained are useful as additives in inks, varnishes, lacquers, coatings, thickeners, adhesives or binders.
US10239958B2 Process for modifying starches
A process for modifying starch comprises atomising an aqueous slurry of non-pregelatinised starch into an internal chamber in a bi-fluid nozzle of a spray dryer and treating the atomized slurry, in the internal chamber, with superheated steam to cause partial gelatinisation of the starch. The aqueous slurry containing partially gelatinised starch is discharged through an outlet in the internal chamber into a reactor where the droplets containing the partially gelatinised starch are subjected to further treatment with superheated steam, resulting in the completion of the gelatinisation of the starch in the reactor. Also disclosed is a bi-fluid nozzle for use in spray drying starch which comprises a nozzle body, a nozzle cap and an internal chamber located between the nozzle body and the nozzle cap. The nozzle body comprises at least one atomiser, for connection to a supply of an aqueous starch slurry, for atomising the slurry into the internal chamber and it has at least one inlet, for connection to a supply of superheated steam under pressure, for introducing superheated steam under pressure into the internal chamber. The nozzle cap comprises at least one outlet from the internal chamber. The internal chamber also comprises an interchangeable spacer element with a length of from 10 to 60 mm enabling the length of the internal chamber to be changed. A pregelatinised starch and its use in foods, especially baby foods and infant formulas, feed, pharmaceuticals, cosmetics and personal care products are also disclosed.
US10239957B2 Peptide containing conjugates for dual molecular delivery of oligonucleotides
Disclosed herein is a peptide containing conjugate comprising (P)c-(L)d-(G)e, wherein P is a peptide and each occurance of P is independently selected from Table 2; L is an optional linker and each occurance of L, if present, is independently selected from Table 3; G is a targeting ligand and each occurance of G is independently selected from Table 4; d is 0, 1, 2, 3, 4, 5 or 6; and each of c and e is independently 1, 2, 3, 4, 5 or 6. The conjugate can be administered to a subject either alone or in combination with a composition comprising R-(L)a-(G)b, wherein R is an oligonucleotide as defined herein, to inhibit expression of a gene of the subject.
US10239956B2 Nucleic acid encoding bone marrow stromal antigen 1 antibody
The invention provides antibodies which bind to the ADP-ribosyl cyclase 2. Nucleic acid molecules encoding the antibodies, expression vectors, host cells and methods for expressing the antibodies are also provided. The antibodies may be used for the treatment of human cancers, including acute myeloid leukemia (AML), B-cell chronic lymphocytic leukemia, breast cancer, colorectal cancer, kidney cancer, head and neck cancer, lung cancer, ovarian cancer and pancreatic cancer and human inflammatory diseases, including asthma, gout, crohns, lupus, multiple sclerosis, rheumatoid arthritis, psoriasis, diabetes and atherosclerotic.
US10239954B2 Antibodies specific for urokinase-type plasminogen activator and methods of use thereof for treating cancer
The present disclosure relates to antibodies specific for urokinase-type plasminogen activator (uPA). According to certain embodiments, the anti-uPA antibody specifically binds to the active form of uPA. In certain aspects, the anti-uPA antibody that specifically binds to active uPA binds specifically to the active form of human uPA (e.g., the antibody does not cross-react with active forms of uPA from non-human organisms). In certain aspects, an anti-uPA antibody of the present disclosure competes for specific binding to uPA with plasminogen activator inhibitor type 1 (PAI-1), where binding of the antibody to uPA results in internalization of a complex that includes the antibody, uPA, and urokinase-type plasminogen activator receptor (uPAR). Also provided are antibodies that specifically bind to uPA and compete for binding to uPA with a synthetic ligand of uPA. The disclosure also provides anti-uPA antibody conjugates and compositions (e.g., pharmaceutical formulations) comprising the antibodies and/or conjugates. Methods and kits related to the anti-uPA antibodies, conjugates, or formulations including the antibodies and/or conjugates are also provided.
US10239953B2 Dual targeting of TAFI and PAI-1
Disclosed herein is a bispecific inhibitor for use in treating thrombotic disorders, such as acute thrombotic disorders like stroke and thromboembolism. The bispecific inhibitor is based on monoclonal antibodies targeting TAFI and PAI-1, and shows efficacy in the presence or the absence of plasminogen activators such as tissue-type plasminogen activator (tPA).
US10239945B2 Therapeutic CD47 antibodies
Provided are anti-CD47 monoclonal antibodies (anti-CD47 mAbs) with distinct functional profiles as described herein, methods to generate anti-CD47 mAbs, and to methods of using these anti-CD47 mAbs as therapeutics for the prevention and treatment of solid and hematological cancers, ischemia-reperfusion injury, cardiovascular diseases, autoimmune diseases, inflammatory diseases or as diagnostics for determining the level of CD47 in tissue samples.
US10239943B2 Treatment of eosinophil or mast cell related disorders
Provided herein are methods and uses involving antibodies that specifically bind to a KIT receptor tyrosine kinase for managing, treating, or preventing an eosinophil or mast cell related disorder and/or one or more symptoms thereof, for example a mast cell related disorder of the nervous system, e.g., central nervous system, for example neuromyelitis optica (NMO), neuromyelitis optica spectrum disorder (NMOSD), multiple sclerosis (MS), and neurofibromatosis (NF).
US10239941B2 Anti-hepcidin antibodies and uses thereof
The present application relates to antibodies that specifically bind to hepcidin and methods of using the antibodies. Another aspect relates to antibodies which bind hepcidin and regulate iron homeostasis. Another aspect relates to the use of humanized antibodies which bind hepcidin for the treatment of a disease or condition associated with hepcidin.
US10239939B2 Anti-ED-A immunoconjugates for inflammatory bowel disease
Specific binding members that bind the ED-A isoform of fibronectin for use in methods of treatment, diagnosis, detection and/or imaging of inflammatory bowel disease (IBD), and/or for use in delivery to the IBD tissue of a molecule conjugated to the specific binding member. The specific binding member may, for example, be conjugated to an immunosupressive or anti-inflammatory molecule, such as interleukin-10.
US10239929B2 Peptide analogs for treating diseases and disorders
Provided herein are methods for the treatment of type I diabetes, Type II diabetes, metabolic syndrome, or obesity, or of appetite suppression, or for mitigating insulin resistance, or for reducing an undesirably high fasting serum glucose level, or for reducing an undesirably high peak serum glucose level, or for reducing an undesirably high peak serum insulin level, or for reducing an undesirably large response to a glucose tolerance test in synergistic combination with metformin. A peptide selected from sequences SEQ ID NO: 12, SEQ ID NO: 15 and SEQ ID NO: 17 are administered.
US10239928B2 Method of highly expressing target protein from plant using RbcS fusion protein and method of preparing composition for oral administration of medical protein using target protein expression plant body
The present invention provides a plant expressing a target protein, a method of preparing the same and a method of preparing a composition for oral administration of a biopharmaceutical using the same. A target protein expression system using plant cells according to the present invention solves conventional problems in plant cell culture, provides a method of producing a large quantity of target proteins including a biopharmaceutical protein and allowing a target protein to have a resistance to a protease present in a digestive organ, and therefore is very effective to enable commercialization of plant-derived biopharmaceuticals.
US10239925B2 Peptides and combination of peptides for use in immunotherapy against ovarian cancer and other cancers
The present invention relates to peptides, proteins, nucleic acids and cells for use in immunotherapeutic methods. In particular, the present invention relates to the immunotherapy of cancer. The present invention furthermore relates to tumor-associated T-cell peptide epitopes, alone or in combination with other tumor-associated peptides that can for example serve as active pharmaceutical ingredients of vaccine compositions that stimulate anti-tumor immune responses, or to stimulate T cells ex vivo and transfer into patients. Peptides bound to molecules of the major histocompatibility complex (MHC), or peptides as such, can also be targets of antibodies, soluble T-cell receptors, and other binding molecules.
US10239923B2 Specific amyloid beta binding peptides and the use of same for treating and diagnosing alzheimer's dementia
Peptides specifically binding amyloid beta and to methods of treating and diagnosing Alzheimer's dementia using such peptides are provided.
US10239922B2 Fusion proteins of superfolder green fluorescent protein and use thereof
The present disclosure pertains to methods of producing recombinant peptides that contain between 10 and 200 amino acid residues using novel carrier proteins derived from superfolder green fluorescent protein and its mutants.
US10239918B2 Cahuitamycins and methods of making and using the same
Provided herein are biofilm inhibitors obtained from marine microbial derived natural product extracts from Streptomyces gandocaensis, resulting in biofilm inhibitors, cahuitamycins. Also provided are mutant S. gandocaensis, methods of inhibiting biofilm formation, methods of producing, or increasing the production of, cahuitamycins, methods for synthesizing cahuitamycins, and methods of purifying cahuitamycins.
US10239914B2 In-situ solvent recycling process for solid phase peptide synthesis at elevated temperatures
An improvement of deprotection in solid phase peptide synthesis is disclosed. The method includes the steps of adding the deprotection composition in high concentration and small volume to the mixture of the coupling solution, the growing peptide chain, and any excess activated amino acid from the preceding coupling cycle; and without any draining step between the coupling step of the previous cycle and the addition of the deprotection composition for the successive cycle; and with the coupling solution at a temperature of at least 30° C.
US10239906B2 Apparatus and method for obtaining glycoglycerolipids and glycosphingolipids from lipid phases
The present invention relates to an apparatus and method for separating glycoglycerolipids and also glycoglycerolipids and glycosphingolipids from a lipid phase that contains glycoglycerolipids and acyl glycerides or glycoglycerolipids and glycosphingolipids and acyl glycerides, in mild conditions with no hydrolysis and while at the same time effectively depleting the lipid phase of said glycoglycerolipids, glycoglycerolipids and glycosphingolipids and their accompanying substances using an aqueous extraction process.
US10239904B2 Method for producing solid lignin
Lignin-rich starting material is suspended in a first medium, which is acidic and aqueous, to form a aqueous acidic suspension, which is heated and allowed to form two continuous phases, a thermoplastic lignin phase and an aqueous phase. The thermoplastic lignin phase is separated from the aqueous phase and passed through a shape giving process into a second medium which is at a temperature lower than that of the thermoplastic lignin phase and in which the thermoplastic lignin phase is essentially insoluble. Solid lignin formed in the second medium is recovered.
US10239900B2 Processes for producing organophosphorous compounds
The present invention relates to processes for producing organophosporous compositions having low acid content as well as processes for reprocessing partially degraded organophosporous compositions that contain high levels of phosphorous acid. In one embodiment, a process comprises: (a) receiving a solid organophosphite compound that has been recrystallized or triturated, wherein the solid organophosphite compound comprises phosphorous acid; (b) dissolving the solid organophosphite compound in a an aromatic hydrocarbon solvent in the absence of water and free amine, wherein the hydrocarbon solvent comprises an aromatic hydrocarbon, a saturated aliphatic hydrocarbon, or a mixture thereof; and (c) removing undissolved phosphorous acid from the solution, wherein the acid content of the organophosphite following step (c) is 30 ppm or less.
US10239896B2 Hydrosilylation iron catalyst
A hydrosilylation iron catalyst prepared from a two-electron ligand (L) and a mononuclear, binuclear, or trinuclear complex of iron indicated by formula (1), Fe having bonds with carbon atoms included in X and the total number of Fe-carbon bonds being 2-10. As a result of using iron, the hydrosilylation iron catalyst is advantageous from a cost perspective as well as being easily synthesized. Hydrosilylation reactions can be promoted under mild conditions by using this catalyst. Fe(X)a  (1) (in the formula, each X independently indicates a C2-30 ligand that may include an unsaturated group excluding carbonyl groups (CO groups) and cyclopentadienyl groups, however at least one X includes an unsaturated group, a indicates an integer of 2-4 per Fe atom.)
US10239895B2 Compound for specifically binding to amyloid β-protein
Provided is a compound for specifically binding to amyloid β-protein. The compound has thereon a nuclide with a large thermal neutron capture cross section and the compound is capable of specifically binding to the amyloid β-protein. The property of the compound allows it to be used in conjunction with a neutron capture therapy device to eliminate amyloid β-protein. Similarly, when the compound is labelled with radioactive element 11C, the compound can also be used in conjunction with PET/CT for determining the part of the brain where amyloid β-protein is deposited, for diagnosing Alzheimer's disease. Also disclosed is a preparation process for the compound. The beneficial effect of the present disclosure is to make the therapy and diagnosis of Alzheimer's disease more targeted by providing the compound for specifically binding to amyloid β-protein.
US10239894B2 Inhibitors of indoleamine 2,3-dioxygenase
Provided are compounds of formula (I) and pharmaceutically acceptable salts thereof, their pharmaceutical compositions, their methods of preparation, and methods for their use in the prevention and/or treatment of HIV; including the prevention of the progression of AIDS and general immunosuppression.
US10239892B2 Method for producing alkyl-indium compounds and the use thereof
The invention relates to a method for the cost-effective and environmentally friendly production of alkyl indium sesquichloride in high yield and with high selectivity and purity. The alkyl indium sesquichloride produced according to the invention is particularly suitable, also as a result of the high purity and yield, for the production, on demand, of indium-containing precursors in high yield and with high selectivity and purity. As a result of the high purity, the indium-containing precursors that can be produced are particularly suitable for metal organic chemical vapor deposition (MOCVD) or metal organic vapor phase epitaxy (MOVPE). The novel method according to the invention is characterized by the improved execution of the method, in particular a rapid process control. Owing to targeted and extensive use of raw materials that are cost-effective and have a low environmental impact, the method is also suitable for use on an industrial scale.
US10239889B1 Pentacyclic compound
The present invention provides compounds represented by formulas (1) to (VI) or pharmaceutically acceptable salts thereof:
US10239888B2 Targeted protein degradation using a mutant E3 ubiquitin ligase
The present application provides bifunctional compounds of Formula I or II: or an enantiomer, diastereomer, or stereoisomer, or a pharmaceutically acceptable salt thereof, which act as protein degradation inducing moieties. The present application also relates to methods for the targeted degradation of endogenous proteins through the use of the bifunctional compounds of Formula (I) or (II) that link a mutant cereblon-binding moiety to a ligand that is capable of binding to a targeted protein which can be utilized in the treatment of proliferative disorders. The present application also provides methods for making compounds of the application and intermediates thereof. The present application also relates to polynucleotides or polypeptides of a mutant cereblon and methods of use thereof.
US10239873B2 7-azaindole or 4,7-diazaindole derivatives as IKKϵ epsilon and TBK1 inhibitor and pharmaceutical composition comprising same
Provided are 7-azaindole or 4,7-diazaindole derivatives as an IKKε (I-kappa-B kinase epsilon) and TBK1 (TANK-binding kinase 1) inhibitor. The 7-azaindole or 4,7-diazaindole derivative effectively inhibits IKKε and TBK1, and thus is useful not only as an anticancer agent for the treatment of various cancers including colorectal cancer, breast cancer, CNS cancer, colon cancer, non-small cell lung cancer, kidney cancer, prostate cancer, ovarian cancer, uterus cancer, stomach cancer, liver cancer, skin cancer, lung cancer, brain cancer, bladder cancer, esophageal cancer, pancreatic cancer, thyroid cancer, head and neck cancer, squamous cell carcinoma, osteosarcoma, B-cell or T-cell lymphoma, acute or chronic leukemia and multiple myeloma, but as a therapeutic agent for chronic inflammation.
US10239871B2 Compounds and methods for regulating integrins
A method of treating inflammation, by administering an effective amount of a β2 integrin agonist to a patient, and reducing inflammation. A method of treating cancer, by administering an effective amount of a β2 integrin agonist to a patient, and reducing tumor growth. A method of treating a patient exposed to radiation, by administering an effective amount of a β2 integrin agonist to the patient after radiation exposure, and mitigating the effects of radiation exposure in the patient. A method of preventing effects of radiation, by administering an effective amount of a β2 integrin agonist to the patient prior to radiation exposure, and preventing the effects of radiation exposure on the patient. A method of treating acquired bone marrow failure (BMF), by administering an effective amount of a β2 integrin agonist to a patient. Methods of improving the health of damaged vasculature in a patient and activating β2 integrins.
US10239869B2 Sulfonamide compounds as voltage-gated sodium channel modulators
The present invention relates to sulfonamide compounds Formula (I) wherein the substituents are as described herein, and their use in a medicine for the treatment of diseases, disorders associated with the inhibition of Voltage-gated sodium channels (VGSC) particularly NaV1.7. It further relates to the compounds herein and their pharmaceutically acceptable salts thereof, pharmaceutical compositions thereof useful in treating diseases, disorders, syndromes and/or conditions associated with the inhibition of Voltage-gated sodium channels (VGSC) particularly NaV1.7. The invention also relates to process for the preparation of the compounds of the invention.
US10239864B2 2-H-indazole derivatives as cyclin-dependent kinase (CDK) inhibitors and therapeutic uses thereof
Indazole compounds of formula (I) as cyclin-dependent kinase (CDK) and cell-proliferation inhibitors, and therapeutic uses and methods of preparation thereof, are disclosed. These compounds, and pharmaceutically acceptable salts, solvates, prodrugs, and pharmaceutical compositions thereof, are useful for treating diseases and disorders associated with activity of cyclin-dependent kinases, in particular CDK4/6, including but not limited to various cancers and inflammation-related diseases or conditions.
US10239863B2 Factor XIa inhibitors
The present invention provides a compound of Formula (I) and pharmaceutical compositions comprising one or more said compounds, and methods for using said compounds for treating or preventing thromboses, embolisms, hypercoagulability or fibrotic changes. The compounds are selective Factor XIa inhibitors or dual inhibitors of Factor XIa and plasma kallikrein.
US10239859B2 Nitrogen-containing heterocycles as pesticides
The present application relates to novel heterocyclic compounds, to processes and intermediates for the preparation thereof, and their use for controlling animal pests.
US10239848B2 Cyclohexenyl compounds, compositions comprising them and uses thereof
Compositions that include certain phenyl substituted cyclohexenyl compounds are administered to a subject in a method for treating obesity or an associated disease or disorder or in a method of reducing food consumption or body weight.
US10239847B1 Method for 2-oxothiazolidine-4-carboxylic acid for cellular glutathione
Provided herein is a composition, method of manufacture, and method for treating a disease condition and/or raising cellular levels of glutathione, the composition comprising L-2-oxothiazolidine-4-carboxylate, (procysteine) having a purity of at least 99 to 99.5 percent.
US10239844B2 Disubstituted triazole analogs
The present invention relates to disubstituted triazoles, their synthesis, and their use as anti-cancer compounds. In particular, compounds of Formula (I) are provided.
US10239841B2 Method for producing pyrazole derivative
The invention relates to a production method of pyrazole derivative (6) by reacting compound (5) with an oxidant. wherein R1, R2, R3, X1, X2 and Z1 are as defined herein.
US10239838B2 Heteroaryl orexin receptor antagonists
The present invention is directed to heteroaryl compounds which are antagonists of orexin receptors. The present invention is also directed to uses of the compounds described herein in the potential treatment or prevention of neurological and psychiatric disorders and diseases in which orexin receptors are involved. The present invention is also directed to compositions comprising these compounds. The present invention is also directed to uses of these compositions in the potential prevention or treatment of such diseases in which orexin receptors are involved.
US10239835B2 N-alkylaryl-5-oxyaryl-octahydro-cyclopenta[c]pyrrole negative allosteric modulators of NR2B
The present invention relates to N-alkylaryl-5-oxyaryl-octadihydrocyclopent[c]pyrrole negative allosteric modulators of NR2B receptors useful in the treatment of neurological diseases having the Formula I where R1, R2, L1, L2, X, Y, and Y′ are described therein. In an aspect, compounds of formula I are described and pharmaceutically acceptable salts, prodrugs, solvates, hydrates, tautomers, or stereoisomers thereof wherein: L1 is straight or branched C1-C5 alkyl optionally substituted with one or more substituents selected from the group consisting of OH, ORIO, NH2, NHRio, and N(Rlo)(Rio′) provided that no more than one oxygen or nitrogen is attached to any carbon.
US10239834B2 Antibiotic sensitivity-restoring and photosensitive agents
The present disclosure describes a method to treat conditions, including bacterial infections and cancer, using a photosensitive compound that, upon exposure to white light, can be activated. The photosensitive compound can also interact synergistically with antibiotics used concomitantly to kill drug-resistant bacteria. The photosensitive compounds can also be used to inhibit the proliferation of cancer cells.
US10239833B2 Intermediates, their process and use in preparation of selective α1-adrenoceptor antagonists, Silodosin
The present invention provides novel process for the preparation of the α1-adrenoceptor antagonists, Silodosin and its pharmaceutically acceptable salts indoline compounds, utilizing derivatives of Formula 1 and salts thereof.
US10239832B2 N-(1-hydroxy-3-(pyrrolidinyl)propan-2-yl)pyrrolidine-3-carboxamide derivatives as glucosylceramide synthase inhibitors
Described herein are compounds of Formula I, methods of making such compounds, pharmaceutical compositions and medicaments containing such compounds, and compounds I for use to treat or prevent diseases or conditions associated with the enzyme glucosylceramide synthase (GCS).
US10239830B2 Benzenesulfonamide upregulators of NPC1 for Neimann-Pick disease and other lysosomal storage disorders
Methods and compositions for treating lysosomal storage disorders are disclosed. The methods involve administering a genus of benzenesulfonamides, particularly N-[3-(aminosulfonyl)phenyl]-benzamides and heteroarylamides. A genus of suitable compounds is shown in formula 1:
US10239826B2 Method for producing isocyanates
A method for producing isocyanates by reacting primary amines with phosgene in a stoichiometric excess in the gas phase, wherein the excess phosgene is subsequently recovered and recirculated back into the reaction. particular a method for the feedback-controlled recirculation of the recovered phosgene, particularly when the phosgene stream that should be recovered is distributed between multiple gas-phase reactors operated in parallel.
US10239823B2 Process for purifying long chain amino acids
There is disclosed a process for the purification of long chain amino acids by recrystallization in an aqueous solution of organic carboxylic acid in the absence or presence of solvent, comprising: (1) dissolving a long chain amino acid in an aqueous solution of organic carboxylic acid by heating; (2) cooling the solution of step (1) to crystallize the long chain amino acid; and (3) recovering the long chain amino acid of step (2) by means of solid-liquid separation.
US10239812B2 Systems and methods for synthesis of phenolics and ketones
Embodiments herein relate to apparatus and systems for phenolic and ketone synthesis and methods regarding the same. In an embodiment, a method of producing phenolics and ketones is included. The method can specifically include forming a reaction mixture comprising nanocrystalline cellulose (NCC) and water. The method can also include contacting the reaction mixture with a metal oxide catalyst at a temperature of 350 degrees Celsius or higher and a pressure of at least about 3200 psi to form a reaction product mixture. The reaction product mixture can include at least about 20 wt. % phenolics and at least about 10 wt. % ketones as a percentage of the total mass of nanocrystalline cellulose (NCC). Other embodiments are also included herein.
US10239810B2 Process for aldehyde manufacture
The process of the invention is a process for the production of an aldehyde from the corresponding alcohol comprising the steps of feeding to a reactor a feed stream comprising said alcohol and an oxygen-containing gas; reacting said alcohol in the gas phase with said oxygen-containing gas in said reactor in the presence of a catalyst comprising oxides of iron and molybdenum, wherein the process further comprises the step of adding water to said feed stream. The process is particularly useful for the production of formaldehyde by the oxidation of methanol.
US10239808B1 Cannabis extracts
A method is provided for removing THC from raw cannabis oil.
US10239804B2 Process for the preparation of 2,3,3,3-tetrafluoropropene from methyl chloride and chlorodifluoromethane
The present invention relates to a process for preparation of olefins containing fluorine.
US10239803B2 Process for the preparation of vinyl chloride
A process for the production of vinyl chloride comprises the step of passing a feed stream comprising ethylene dichloride (EDC) over a catalyst system comprising a dehydrochlorination catalyst and a hydrochlorination catalyst at a temperature, which may be in the range 150-350° C., sufficient to effect dehydrochlorination of the ethylene dichloride to produce vinyl chloride.
US10239802B2 Processes and apparatuses for toluene methylation in an aromatics complex
This present disclosure relates to processes and apparatuses for toluene methylation in an aromatics complex for producing paraxylene. More specifically, the present disclosure relates to processes and apparatuses wherein a toluene methylation zone is integrated within an aromatics complex for producing paraxylene thus allowing no benzene byproduct to be produced. This may be accomplished by incorporating a toluene methylation process into the aromatics complex and recycling the benzene to the transalkylation unit the aromatics complex.
US10239800B2 Catalyst and process for selective production of lower hydrocarbons C1—C5 from syngas with low methane and CO2 production
A catalyst composition containing cobalt manganese oxide which is modified with silicon in the form of a hydrophilic silica, the catalyst also containing at least one of lanthanum, phosphorus, Fe, Zr, and Zn, and optionally one or more basic elements selected from the group of alkali metal, alkaline earth metal, and transition metals. Also, methods for preparing and using the catalyst composition for producing aliphatic and aromatic hydrocarbons using the catalyst composition.
US10239799B2 Reaction products and methods for making and using the same
Reaction products and methods for making and using the same are provided. The reaction products particularly may include adducts of two or more reactants. The adducts particularly can incorporate a nitrification inhibitor, such as DCD. In particular embodiments, reaction products may be formed from the reaction of formaldehyde, DCD, urea, and an ammonia source. The adducts may be included in agricultural products, including fertilizer compositions and nitrification inhibitor systems. Fertilizer compositions including the adducts can be beneficial for reducing leaching of nitrification inhibitors applied to soil.
US10239798B2 Seed treatment methods and compositions
Disclosed are methods of enhancing plant growth, comprising treating seed at least one month prior to planting with an effective amount of a plant signal molecule, wherein upon harvesting the plant exhibits at least one of increased plant yield measured in terms of bushels/acre, increased root number, increased root length, increased root mass, increased root volume and increased leaf area, compared to plants harvested from untreated seed, or compared to plants harvested from seed treated with the signal molecule just prior to or within a week or less of planting.
US10239797B2 Micronutrient fertilizers and methods of making and using the same
A water insoluble micronutrient fertilizer, methods of producing, and methods of using the same are provided. The fertilizer may comprise at least one first micronutrient selected from the group consisting of chromium, cobalt, copper, iron, manganese, and zinc; a polyphosphate; and optionally at least one second micronutrient selected from the group consisting of boron, chlorine, iodine, molybdenum or selenium. The fertilizer compounds are preferably water insoluble, dilute acid soluble, and free-flowing powders.
US10239796B2 Tooling for use during heat treatment to support a preform made of powder
The invention provides tooling (100) for acting during heat treatment to support a preform (110) of a three-dimensional part obtained by shaping a metal or ceramic powder, the preform presenting at least one bearing surface (112) on which it can rest and at least one suspended surface (111) that is suspended relative to the bearing surface, the tooling comprising a tray (120), and a plurality of blocks (130) arranged on the tray and each having at least one surface (130a) for supporting the preform, the blocks being suitable for moving relative to one another by sliding on the tray between a first position in which the blocks are spaced apart from one another and together define a first volume, and a second position in which the blocks together define a second volume that is smaller than the first volume. The invention also provides a method of heat treating a preform made of powder and using such tooling.
US10239791B2 Refractory ceramic batch composition, use of a batch composition of this type, and metallurgical melting vessel
The invention relates to a refractory ceramic batch for the production of an unformed refractory ceramic batch, the use of a batch of this kind for lining metallurgical melting vessels and also a metallurgical melting vessel which is lined with an unformed refractory ceramic product based on a batch of this kind.
US10239790B2 Low-density high-strength concrete and related methods
A low-density, high-strength concrete composition that is both self-compacting and lightweight, with a low weight-fraction of aggregate to total dry raw materials, and a highly-homogenous distribution of a non-absorptive and closed-cell lightweight aggregate such as glass microspheres or copolymer polymer beads or a combination thereof, and the steps of providing the composition or components. Lightweight concretes formed therefrom have low density, high strength-to-weight ratios, and high R-value. The concrete has strength similar to that ordinarily found in structural lightweight concrete but at an oven-dried density as low as 40 lbs./cu.ft. The concrete, at the density ordinarily found in structural lightweight concrete, has a higher strength and, at the strength ordinarily found in structural lightweight concrete, a lower density. Such strength-to-density ratios range approximately from above 30 cu.ft/sq.in. to above 110 cu.ft/sq.in., with a 28-day compressive strength ranging from about 3400 to 8000 psi.
US10239786B2 Geopolymers and geopolymer aggregates
The invention relates to geopolymer compositions, geopolymers and methods for their production and use. The geopolymers may be used as aggregates, and those aggregates may be used in concrete manufacture. The geopolymer composition comprises fly ash or a fly ash substitute, an aluminum phyllosilicate, an alkaline component and water, wherein the water is present at an amount of about 6% to about 10% by weight of the composition. The geopolymers are made by forming a geopolymer composition as described above, compacting the mixture by applying pressure of about 50 to about 90 kgf/cm2; and curing the compacted mixture to form the geopolymer.
US10239778B2 Apparatus and method for severing a glass sheet
A method for severing a glass sheet includes preferentially heating a region of the glass sheet to form a softened region. A slit is formed in the softened region of the glass sheet to form a slit region. The slit extends at least partially into a thickness of the glass sheet. Heat is preferentially applied to the slit region of the glass sheet.
US10239777B2 Method for ultra-dehydrating thickened or pasty biomass products, and equipment for implementing the method
The invention relates to a method for ultra-dehydrating thickened or pasty biomass products, in particular sludge from wastewater treatment plants, according to which the products, in particular products having a dryness of 4% to 25%, are subjected to the following steps: hydrothermal carbonization treatment, including pressurization (1, 2) and thermal conditioning (30) for a duration in a closed reactor (4); followed by dehydration of the products by a ram press (12), obtaining a dryness of more than 50%; the temperature of the product upstream from the ram press dehydration being regulated by cooling between 40° C. and 90° C., advantageously to around 70° C., in order to optimize the filterability in the piston press; the steps of the method being performed in a confined space making it possible to prevent the release of smells into the atmosphere.
US10239772B2 Recycling loop method for preparation of high concentration ozone
The present invention relates to an apparatus for the production of ozone from water comprising at least one cell, consisting of an anode, a cathode and an interposed cation-conducting membrane, wherein the membrane conductively connects the anode and the cathode while forming flow channels for water that are separated from one another as anode and cathode chambers and wherein the flow channels are configured to allow for the recirculation of the water flow within the chambers. The present invention further relates to an electrochemical method and apparatus for producing ozone or dissolved ozone in water in high concentrations by mean of recirculation of water between at least one chamber and at least one water tank.
US10239766B2 Evaporator sump and process for separating contaminants resulting in high quality steam
A horizontal sump for producing high quality steam, includes at least one inlet, for connection to an evaporator, for receiving steam and contaminated water from the evaporator, the evaporator having a tube side and a shell side. The horizontal sump further includes at least one steam outlet for feeding steam to an evaporator compressor. The at least one steam outlet further includes at least one wash tray, for washing any entrained brine from the steam prior to introduction of the steam to the evaporator compressor, wherein the horizontal sump increases residence time of water and steam in the sump resulting in a steam of quality greater than that of the steam from the steam and contaminated water from the evaporator.
US10239759B2 Method of producing silica-based particles
A method of producing silica-based particles includes, when a dispersion liquid of composite oxide particles is prepared by simultaneously adding an aqueous silicate solution and/or an acidic silicic acid solution and an aqueous solution of an alkali-soluble inorganic compound in an alkali aqueous solution or in an alkali aqueous solution with seed particles dispersed therein, if required, the aqueous silicate solution and/or the acidic silicic acid solution and the aqueous solution of alkali-soluble inorganic compound are added so that the molar ratio of MOx/SiO2 are in a range from 0.01 to 2, herein MOx denoting an inorganic oxide other than silica and SiO2 denoting silica to prepare the dispersion liquid of composite oxide particles with an average diameter (Dp1) in a range from 3 to 300 nm.
US10239758B2 Silica sol and method for producing silica sol
A silica sol which has excellent moisture absorption resistance and stability as well as high purity and which does not cause coloring of a solvent or a resin to which the silica sol has been applied. The silica sol contains high-purity silica particles, water and/or a liquid organic medium serving as a dispersion medium, and an organic base compound, the silica particles being dispersed in the dispersion medium, wherein the silica particles satisfy the following requirements (a) to (c): (a) the silica particles have a specific surface area, as determined through a nitrogen absorption method, of 20 to 500 m2/g; (b) the silica particles have a moisture absorption amount per specific surface area thereof of 0.5 mg/m2 or less; and (c) the organic base compound is not substantially contained in the inside thereof.
US10239753B2 Composite material for hydrolytically generating hydrogen, device for hydrolytically generating hydrogen, method for generating hydrogen, device for generating electric energy, and possible applications
The invention relates to compact and lightweight disposable accumulators for generating electric energy with extremely high energy densities (>1 kWh/kg and >k Wh/liter), which are of immense interest in many areas of application. One possibility for implementing such energy accumulators consists in using metal hydrides in hydrogen generators in which hydrogen is generated by hydrolytically splitting off a proton from water in conjunction with the metal hydride. The chemical energy stored in the hydrogen can then be converted into electric energy in a fuel cell in a second step. Only half of the generated hydrogen originates from the metal hydride during the hydrolysis reaction; the water used for the hydrolysis process supplies the other half.
US10239751B2 Wafer-level package with enhanced performance
The present disclosure relates to a wafer-level package that includes a first thinned die, a multilayer redistribution structure, a first mold compound, and a second mold compound. The first thinned die includes a first device layer formed from glass materials. The multilayer redistribution structure includes redistribution interconnects that connect the first device layer to package contacts on a bottom surface of the multilayer redistribution structure. Herein, the connections between the redistribution interconnects and the first device layer are solder-free. The first mold compound resides over the multilayer redistribution structure and around the first thinned die, and extends beyond a top surface of the first thinned die to define an opening within the first mold compound and over the first thinned die. The second mold compound fills the opening and is in contact with the top surface of the first thinned die.
US10239748B2 Microelectromechanical device with protection for bonding
A microelectromechanical device includes: a substrate; a semiconductor die, bonded to the substrate and incorporating a microstructure; an adhesive film layer between the die and the substrate; and a protective layer between the die and the adhesive film layer. The protective layer has apertures, and the adhesive film layer adheres to the die through the apertures of the protective layer.
US10239743B2 Fitting for a cask having an overpressure function
A fitting arrangement for a cask is disclosed having a fitting sleeve with a riser pipe arranged therein, and resiliently moveable relative thereto. The fitting sleeve has a conically extending inner sealing surface tapering toward an upper end, and a seal is incorporated between the inner sealing surface and the upper end of the riser conduit. The riser pipe is pressed with the seal against the sealing surface with a spring force, and the seal is arranged internally in the upper end of the riser pipe, wherein a sealing body is arranged in the upper end of the riser pipe and is resiliently moveable relative thereto, which sealing body comes to bear with form-fit engagement on an internal sealing surface of the seal as a result of the spring force.
US10239740B2 Shopping facility assistance system and method having a motorized transport unit that selectively leads or follows a user within a shopping facility
A shopping facility assistance system includes a plurality of motorized transport units, a plurality of user interface units, and a central computer system having a network interface such that the central computer system wirelessly communicates with one or both of the motorized transport units and the user interface units. The central computer system is configured to control movement of the motorized transport units through a shopping facility space based at least on inputs from the user interface units. More particularly, the central computer system controls movement of the motorized transport units such that a given one of the plurality of motorized transport units selectively leads a user to a destination within the shopping facility or follows the user within the shopping facility as determined by the central computer system. By one approach, the motorized transport units move through the shopping facility via a plurality of preferred pre-determined path segments.
US10239738B2 Apparatus and method of monitoring product placement within a shopping facility
Methods and apparatuses are provided for use in monitoring product placement within a shopping facility. Some embodiments provide an apparatus configured to determine product placement conditions within a shopping facility, comprising: a transceiver configured to wirelessly receive communications; a product monitoring control circuit coupled with the transceiver; a memory coupled with the control circuit and storing computer instructions that when executed by the control circuit cause the control circuit to: obtain a composite three-dimensional (3D) scan mapping corresponding to at least a select area of the shopping facility and based on a series of 3D scan data; evaluate the 3D scan mapping to identify multiple product depth distances; and identify, from the evaluation of the 3D scan mapping, when one or more of the multiple product depth distances is greater than a predefined depth distance threshold from the reference offset distance of the product support structure.
US10239736B1 Rope retainer for a boom
An apparatus assists in retaining a rope in connection with a sheave on a boom. The apparatus includes a retainer supported by the boom for swinging outwardly relative to the sheave from a first position adjacent to the sheave for assisting in retaining the rope therein and a second position for facilitating removing the rope from the sheave. A holder may be provided for holding the retainer in the second position, so that the operator's hands are freed for other tasks. A receiver may also be provided for temporarily receiving a locking pin once removed from the retainer, thus helping to guard against loss.
US10239734B2 Method for lowering a subsea structure having a substantially flat support base into the water through the splash zone
The present invention relates to a method for lowering a subsea structure to be installed on the seabed into the water through the splash zone, said subsea structure comprising subsea equipment arranged on a substantially flat support base for preventing the subsea equipment to sink into the seabed. The method according to the invention comprises: lifting the subsea structure into the air in a horizontal position in which the flat support base extends substantially parallel to the horizontal plane; tilting the subsea structure while suspended in the air from the horizontal position into a tilted position in which the flat support base is angled with respect to the horizontal plane; lowering the subsea structure into the water through the splash zone in the tilted position; and tilting the subsea structure while suspended in the water below the splash zone back into the horizontal position.
US10239732B2 Conveyor device with moving comb plate in the longitudinal direction
A conveyor device includes a truss; a conveyance element, which is movable with respect to the truss in a longitudinal direction and which includes at least one groove extending along said longitudinal direction. The conveyor device further includes a comb plate having at least one tooth extending into the at least one groove. For minimizing the effects resulting from a comb crash, the conveyor device further includes at least one compensation device fixing the comb plate in the longitudinal direction during normal operation, but allowing the comb plate to move in the longitudinal direction in case of a comb crash.
US10239726B2 Ribbon self-orienting device for traversed rolls
A ribbon self-orienting device that is to be interposed between the source and the target of a traveling ribbon, either during winding of a ribbon into a traversed roll or during pay-off of a ribbon from a traversed roll. A pivoting frame is pivotally coupled to a frame support, at a pivot axis. First and second direction changing means coupled to the pivoting frame serve to change the direction of the traveling ribbon. A force transfer means transfers a transversely directed force, imparted by the traveling ribbon due to the ribbon traversing its traversed roll while under tension, to the pivoting frame causing the pivoting frame to move about the pivot axis. Other embodiments are also described.
US10239724B2 Systems and methods for folding a stack of substrate sheets
Systems and methods for folding a stack of substrate sheets are provided. The system may include a roller assembly and a positioning mechanism. The roller assembly is configured for folding the stack of substrate sheets and the positioning mechanism is configured to position the substrate or stack for entry into the roller assembly. The positioning mechanism includes an upper curved form and a lower curved form to guide the stack of substrate sheets into a curved position for folding. The positioning mechanism further includes a folding blade positioned to extend through the gap between the upper and lower curved forms. The roller assembly can move the folded stack of substrate sheets in at least two directions.
US10239723B2 Sheet processing apparatus and image forming apparatus
There is provided a sheet processing apparatus with improved visibility of a sheet bundle discharged without post-processing thereto. The CPU circuit receives the conveyed sheet, drives and controls the sheet-returning paddle, the rack part, the rear end regulation part, the alignment plate and the like and forms sheet bundle comprising of a plural number of sheets as received. Further, the CPU circuit drives and controls the alignment plate when discharging the sheet bundle S from the processing tray, the sheet bundle S exceeding the number of sheets which can be post-processed by the stapler. Therefore, the sheet bundle S which includes sheets equal to the allowable number of sheets for post-processing of the sheet processing unit is discharged to the second discharge position which is different from the first discharge position.
US10239720B2 Web winding device
The present invention provides an improved belted reel which is particularly well suited for the winding of soft, bulky tissue webs and overcomes the limitations of the prior art. The belted reel is capable of providing coordinated web tension and nip control by providing the winding parent roll with two nip points—the first nip formed between the winding roll and the second between the winding roll and a second support drum. Preferably the drum encircled by the endless belt lies above the second support drum and the first and second nip points lie in the same vertical plane.
US10239718B1 Sheet feeder
A contact member swingably moves about a swing axis to contact a recording medium stacked on a medium tray, and shifts to different states depending on volume of medium. A controller performs: a detection process of detecting the stacked volume based on signals of M times outputted from the sensor, the M times being a number of times that is larger than or equal to two times; a stack determination process of determining whether the recording medium is stacked on the medium tray based on signals of N times, the signals of N times being a part of the signals of the M times outputted from the sensor, the N times being a number of times that is smaller than M; and a sheet feeding process of controlling the feed roller to feed the recording medium, in response to determining that the recording medium is stacked on the medium tray.
US10239717B2 Image forming apparatus, image forming method, and sheet-feeding apparatus
Provided is an image forming apparatus including a manual feed tray for placing a sheet subjected to image formation, a sheet sensor configured to detect whether or not the sheet is placed on this manual feed tray, a pickup roller configured to feed the sheet placed on the manual feed tray, and a controller. When a size of a sheet to be fed is designated by a user, and it is determined that the sheet is placed, the controller causes at least one of the pickup roller and the manual feed tray to start movement to a position of enabling the pickup roller to feed the placed sheet.
US10239716B2 Device and method for transporting substrates in a printing machine
The object of the present invention is to propose a novel device and a novel method to allow the transportation of printable substrates precisely, suited to substrates of various types, sizes and thicknesses. Furthermore, the invention is suited to printing machines that involve no contact with the substrate, such as inkjet printing machines.
US10239715B2 Sheet folding method, image forming system, and sheet folding device with motor employing being controlled to perform a feedback control with an integral gain
A sheet folding device, which is included in an image forming system and uses a sheet folding method, includes first and second drive motors, a first sheet conveyor driven by the first drive motor and configured to receive and convey a sheet toward a downstream side of a sheet conveying direction, a second sheet conveyor driven by the second drive motor and configured to receive the sheet conveyed from the first sheet conveyor and to convey the sheet to the downstream side of the sheet conveying direction, and a controller configured to fold the sheet to a predetermined folding length set according to an amount of conveyance of the sheet by the second sheet conveyor while the sheet is being held between the first and second sheet conveyors, and to perform a feedback control with an integral gain to the second drive motor.
US10239711B2 Transportable receiving and storage system
A system has a surge bin, a distribution conveyor assembly, an elevating conveyor assembly, and a receiving conveyor assembly. The surge bin has an internal storage compartment, a top input opening, and a bottom output opening. The distribution conveyor assembly has a distribution frame attached at an input end thereof to an upper portion of the surge bin, and a distribution conveyor mounted on the distribution frame. The elevating conveyor assembly has an elevating conveyor configured to receive granular material at an elevating input and discharge the received granular material selectively to the top input opening of the surge bin or to the distribution conveyor input. The receiving conveyor assembly has a receiving station configured to receive granular material from a discharge of a transport vehicle, and a receiving conveyor operative to transfer the received granular material from the receiving station into the elevating input.
US10239704B2 Method and conveying technology element for combining conveyor streams in a conveyor system
A method combines conveyor streams on a conveying technology element having a number of ingoing conveyor segments at least one coupling to an outgoing conveyor segment on which the ingoing conveyor segments are brought together, and a number of holding devices for holding a conveyor flow on the ingoing conveyor segments. In addition, a number of release devices disposed downstream of the ingoing conveyor segments logically connected to an OR-connection are provided for releasing a holding device or a conveyed object. A holding device or a conveyed object waiting at the holding device is then respectively released when a conveyed object preceding the waiting conveyed object in a sorting order passes one of the connected release devices or when there is no preceding conveyed object. A conveying technology element carries out the method.
US10239700B2 Cam unit and conveying device
The present invention is characterized to include a cylindrical cam that is provided to correspond to a moving path and possesses an engaging groove, the moving path moving in an uncoupled state with each of a plurality of carriers to which an object to be conveyed is respectively installed and the plurality of carriers being in states where a set of a plurality of first carriers and a set of a plurality of second carriers are alternately lined up, and a drive source that drives the cylindrical cam, wherein a first cylindrical cam and a second cylindrical cam, as the cylindrical cam, are respectively provided to correspond to a predetermined position in the moving path, the first cylindrical cam possessing an engaging groove with which only the first carriers are engageable and the second cylindrical cam possessing an engaging groove with which only the second carriers are engageable, a first drive source that drives the first cylindrical cam and a second drive source that drives the second cylindrical cam are included as the drive source, the engaging grooves of the first cylindrical cam and the second cylindrical cam are helical grooves that possess a first groove part and a second groove part, the second groove part being continuous with the first groove part, being positioned on a downstream side in a conveying direction with respect to the first groove part and having a pitch different from the pitch of the first groove part, and the second cylindrical cam rotates to move the second carrier that reached the first groove part when an interval of the first carriers is changed by the set of the plurality of the first carriers moving past the first groove part to reach the second groove part by a rotation of the first cylindrical cam.
US10239699B2 Medicine conveying apparatus
A medicine conveying apparatus includes storage containers and a circulation driving unit configured to circulate the storage containers so as to make a round along a circulation path, wherein an introduction position and a discharge position are set on the circulation path, so that the medicine introduced into each storage container that has arrived at the introduction position, and the medicine is discharged from each storage container that has arrived at the discharge position, the circulation path includes a first directional path and a second directional path, and the circulation driving unit allows an operator to select one of the first and second directional paths through which the storage containers are conveyed from the introduction position to the discharge position and circulates the storage containers through the selected path.
US10239698B1 Vibratory bowl feeder
An improved vibratory bowl feeder is provided. The improved vibratory bowl feeder includes a removable impact cone formed from an impact resistant material to deflect falling industrial workpieces toward the sidewall of a bowl. The impact cone includes a through-hole for a center bolt, the center bolt securing the impact cone to the bowl. An adhesive layer bonds the impact cone to the bowl, which is optionally formed from stainless steel. The impact cone includes a frusto-conical or hemispherical impact surface that deadens the impact from industrial workpieces falling from an overhead hopper. Replacement of the impact cone can be achieved within minimal downtime, and varying impact cones can be selected based on the size and the shape of the industrial workpieces for a given inspection run.
US10239697B2 Flexible element for a conveyor system
A flexible element for conveying goods in a conveyor system is provided. The flexible element includes a base configured to form a top surface, a bottom surface and an intermediate surface; a conveying means detachably mounted on the top surface and; a toothed projection detachably mounted on the bottom surface; and at least one pair of wheels mounted on the intermediate surface. A conveyor system for conveying the flexible element is also provided.
US10239694B2 Warehouse automation systems and methods
A warehouse automation system adapted to improve warehouse operating productivity includes a plurality of carts for transporting products within a warehouse and a controller. The controller is adapted to associate a first one of the plurality of carts with a first person and to control the first cart to lead the first person around the warehouse. According to one advantage, the time the first person spends restocking, picking, counting, sorting, moving, and packing product into customer orders and shipments, for example, is reduced.
US10239691B2 Storage and retrieval system
A storage and retrieval system including a vertical array of storage levels, each storage level having, picking aisles, storage locations, disposed within the picking aisles, and at least one transfer deck providing access to the picking aisles, a multilevel vertical conveyor system configured to transport the uncontained case units to and from the vertical array of storage levels, each storage level being configured to receive uncontained case units from the multilevel vertical conveyor system, at least one autonomous transport located on each storage level for transporting the uncontained case units between respective storage locations and the multilevel vertical conveyor system, and a controller configured to create a primary access path through the transfer decks and picking aisles to a predetermined one of the storage locations and at least one secondary access path to the predetermined one of the storage locations when the primary path is impassable.
US10239687B1 Above ground water tank fill/drain system
A trench is dug under an above ground water storage tank either before erection of the walls or after the wall is erected. A (rectangular) sump is preferably made of ¼ inch steel. It serves as a conduit from an inner tank liner port to an outside tank fill or drain port. The system eliminates hoses hung over the top edge of the tank wall. A pump can fill the tank from the outer port. The tank can be drained using head pressure of the water and/or a pump.
US10239683B2 System and method for protective eyewear dispensing
A system and method for improved dispensing for protective eyewear components, including frames, lenses and assembled protective eyewear glasses, is described. A housing stores and dispenses the eyewear components through an opening. In an embodiment, the eyewear components may be detachably connected together, such as via perforations, and/or may be coiled in a roll or stacked in serpentine configuration within the housing. Also, in one embodiment, a lever of other mechanism may be coupled to the housing to provide advantageous operations of the dispenser, including assembling and/or dispensing the eyewear components. Accordingly, the system and method provides advantages in that rapid and hygienic dispensing of protective eyewear components may be provided.
US10239681B2 Drum unloader
A drum unloader may include a pump assembly, a motor, a plate, a piston-cylinder assembly, and a sensor. The motor drives the pump assembly. The plate is mounted to the pump assembly and includes an inlet to the pump assembly. The piston-cylinder assembly includes a housing, a piston, and a piston rod. The housing defines a bore. The piston is received within the bore and cooperates with the housing to define a first cavity and a second cavity. The piston rod is attached to and extends from the piston such that the piston rod extends through the first cavity. The piston rod is coupled to the pump assembly, the motor and the plate such that movement of the piston within the bore causes corresponding movement of the pump assembly, the motor and the plate relative to the housing. The sensor measures a pressure within the second cavity.
US10239680B2 Blister package containing the laminated sheet and container
A laminated sheet or a container includes: an absorbing layer absorbing at least one of liquid and gas; a reinforcing layer laminated on the absorbing layer with an adhesive layer interposed therebetween; an aluminum layer laminated on the reinforcing layer with an adhesive layer interposed therebetween; and a barrier layer laminated on the aluminum layer with an adhesive layer interposed therebetween and suppressing entry of at least one of liquid and gas.
US10239679B2 Stay-fresh food container
A container for storing a food product includes a receptacle and a plunger slidably movable along an inner wall of the receptacle. The plunger includes a support surface for the food product and a seal configured to form a seal between the support surface and the inner wall. A rounded lid with an apex is configured to be sealingly coupled to the receptacle. The lid includes a vent located at the apex.
US10239677B2 Easy-open media wrapper
A structure is described for forming a wrapper, e.g., for print media, where the structure includes a line of weakness for facilitating a user's tearing of the wrapper to access the contents. The line of weakness may include a first line of weakness portion that extends along a fold line of an envelope fold forming one of the front or rear or right sides of the wrapped package, as well as a second line of weakness portion that extends substantially perpendicularly to the respective longitudinal fold lines and a connecting line of weakness portion that extends between the first line of weakness portion and the second line of weakness portion and is disposed at a non-zero angle with respect to each. In this way, a tear initiated near the first line of weakness portion and may be propagated along the other portions to create an opening for accessing the product.
US10239676B2 Flexible film composition for heat seals and container with same
The present disclosure is directed to compositions and film structures suitable for heat seal production. The heat sealable flexible film structure includes: a layer (A) comprising a blend comprising from 35 to 80 percent by weight of the layer (A) of a propylene based plastomer or elastomer (“PBPE”) and from 20 to 65 percent by weight of the layer (A) of a low density polyethylene having a density in the range of from 0.915 g/cm3 to 0.935 g/cm3, wherein the blend has a melt index (as determined according to ASTM D 1238 (at 190° C./2.16 Kg); a layer (B), adjacent to layer (A), comprising a polyolefin-based polymer, wherein the polymer or polymer blend which makes up layer (B) flows more easily than the blend of layer (A) under conditions intended for making a hard seal with the film structure; and an outermost layer (C) comprising a material having a melting point greater than 140° C.; wherein the ratio of the thickness of layer (B) to the thickness of layer (A) is 3:1 or greater. The heat sealable flexible film structure is used to make a flexible container having one or more heat seals. The heat seal can be a frangible heat seal, a hard heat seal, or a combination of frangible heat seals and hard heat seals depending on the sealing conditions.
US10239674B1 Child-resistant container
Various embodiments of containers are described having a base and a cap that is configured to couple with the base. The base includes a housing having a hollow interior, with the housing extending upwardly from an upper surface of the base. The base also includes a set of flexible tabs that are configured to flex when a force is applied. The housing has a set of outward projections, each of which is configured to be inserted into a recessed portion or notch of the cap when the cap is coupled with the base. The cap further includes a set of downward projections that contact the flexible tabs, such that a downward force applied to the cap causes the flexible tabs to flex downwardly, and the projections of the housing to move within the first and second recessed portions.
US10239672B2 Drip-free glass bottles having a circumferential channel and methods of making and using such bottles
Described herein is a glass bottle configured to improve the mechanics of liquid flow and prevent drip initiation. Additionally, the glass bottle eliminates dripping during pouring to enable drip-free pouring. The dripping is prevented over a full range of pouring angles, which vary depending on the amount of liquid held in the glass bottle. A method of making the glass bottle and a method of enabling drip-free pouring using the glass bottle are also disclosed.
US10239671B2 Liquid dosing apparatus
An apparatus and means of repeatedly dispensing controlled doses of liquid comprising a resiliently squeezable container for containing a liquid detergent composition; a cap operably connected to said container, the cap comprising a nozzle for expelling the liquid out of the container; a dosing chamber operably connected to the cap, wherein the dosing chamber comprises a base having a discharge opening therein, sidewalls extending upwardly along the perimeter of said base and at least one inlet opening located proximal the sidewalls; at least one timer aperture located proximal to the discharge opening; a plunger, provided in the dosing chamber and moveable relative to the chamber so as to advance upon squeezing of the container, up to a blocking position; a valve retaining means located below the base; a valve provided in the valve retaining mean wherein the valve is movable from an open position, allowing liquid flow through the discharge opening, and a closed position, where the valve blocks the discharge opening; wherein the liquid is a shear thinning liquid and the shear thinning liquid has a viscosity of greater than 150 mPa·s measured at 10s−1 at 20° C.
US10239670B2 No spill cap assembly
A cap assembly connected to a container for dispensing the contents of the container includes an inner cap and an outer cap. The inner cap includes a cylindrical inner cap surface between a proximal end and a distal end that includes an inner cap opening. The outer cap is positioned over and secured to the inner cap. The outer cap includes a cylindrical outer cap surface between the proximal end and distal end, and the cylindrical outer cap surface includes an outer cap opening. The cap assembly includes an open configuration and a closed configuration. The outer cap can be rotated about the inner cap between the open configuration and the closed configuration.
US10239667B2 Closure for retort container
A retortable container is formed with an opening formed defined by a projecting rim. The rim includes an external surface and securing structure formed thereon. A flexible membrane is sealed to the rim and closes the opening. A closure is provided having a molded plastic tubular ring and a separately formed molded plastic disk. The tubular ring includes an overlapping flange at a top and directed inwardly towards an inwardly positioned open area. The skirt includes an engagement structure for securing the closure to the external surface of the rim. The disk is separately attached to the ring within the open area after the retort process is applied to the sealed bottle.
US10239661B2 Stackable plastic container
A container for storage and transport of goods includes four sidewalls which surround a first planar bottom and have on their upper end a rim. A second bottom with a multiplicity of bottom ribs is connected to the first bottom by welding the bottom ribs of the second bottom with the first bottom. At least two opposite sidewalls of the container have each a projection which extends away from a sidewall and at a predetermined distance from the sidewall extends parallel to the sidewall in the direction of the bottom of the container. The projection has a horizontal end face which extends parallel to the area of the upper rim of the sidewall, with the horizontal end face extending at a level underneath the bottom plate of the first bottom.
US10239660B2 Three-dimensional structure for storing and displaying an item
Three-dimensional structure is provided that includes an internal structure and an external structure configured to receive the internal structure. The internal structure includes a plurality of walls forming an accommodation opening and a magnetic element configured to be affixed or located within on the plurality of walls. The external structure includes a set of two surfaces having a first configuration of protrusions where the two of two surfaces are adjoining. Another set of two surfaces have a second configuration of protrusions, where the surfaces form at least one opening configured to allow insertion and removal of the internal structure. The set of two surfaces and the another set of two surfaces are configured for mating engagement with another external structure having substantially the same configurations, where the first configuration and the second configuration are configured to couple to each other.
US10239659B2 Container and construction made therefrom
A container for receiving therein a liquid is provided. The container comprises an upper portion, a lower portion opposite thereto, and sidewalls extending therebetween and all defining an enclosed volume therewithin. The upper portion comprises an opening to the volume. The container further comprises a cap configured to be secured to the upper portion for closing the enclosed volume. The upper portion is configured to be connected to the lower portion. The sidewalls are associated with one or more arrangements configured to facilitate connection to sidewalls of similarly constructed containers.
US10239657B2 Method for transporting mattresses and shipping container holding an assembly of stacked bedding products
An assembly of stacked mattresses and a method for preparing such an assembly are provided. The assembly of stacked mattresses comprises a first pallet, a second pallet, a plurality of mattresses positioned between the first pallet and the second pallet and straps coupling the first pallet to the second pallet, the plurality of mattresses being in a compressed state between the first pallet and the second pallet and the straps restraining expansion of the plurality of mattresses. The second pallet is comprised of a supporting member and a plurality of elongated reinforcing members extending across the supporting member, at least some of the reinforcing members including respective strap guiding members extending longitudinally along the elongated reinforcing member. At least some of the straps engage respective ones of the strap guiding members of the plurality of elongated reinforcing member of the second pallet so that displacement of the straps is constrained by the strap guiding members. In accordance with another aspect, a pallet for using in shipping bedding products is provided.
US10239654B2 Packing box
A packing box includes first and second sidewall parts spaced apart and facing each other, first and second connecting parts, a third connecting part attaching the second connecting part to the first sidewall part, a bottom part connecting lower portions of the first and second sidewall parts and the first and second connecting parts, and a top part facing the bottom part and connecting upper portions of the first and second sidewall parts and the first and second connecting parts to form a receiving space. The top part includes first to fourth upper paperboards folded and extended from the upper portions of the first and second sidewall parts and the first and second connecting parts to form a handle, and a fifth upper paperboard folded from the third connecting part and disposed under the first to fourth upper paperboards to prevent withdrawal of contents from the receiving space.
US10239653B2 Flat foldable packaging
A container having both a one-dimensional configuration before it is formed into its three-dimensional configuration. A blank is used to form the container and is initially flat with a plurality of fold lines. The container includes a base portion with a plurality of edges along its perimeter, a lid portion which is distanced from and parallel to the base portion, and a wall projecting orthogonally from each edge forming a plurality of walls. At least one wall is integrally connected to both the base portion and the lid portion.
US10239649B2 Double container and exterior sleeve used in double container
A double container includes: an inner container having a cylindrical barrel portion the upper circumferential edge of which is formed to have a curled portion, and a bottom portion provided on a lower end of the barrel portion so as to close the lower face thereof; and a exterior sleeve) which covers the barrel portion, and is secured thereto, so as to form a thermal insulating space between itself and the outer side of the barrel portion. The outer surface of the barrel portion of inner container is provided over the entire circumference thereof with a plurality of elongated projections, which consist of thermoplastic resin, arranged in a row and spaced apart in the circumferential direction, the projections extending in elongated fashion circumferentially and each having an amount of projection of 1.0 to 2.0 mm.
US10239647B2 Squeezable leak proof feeding bottle
A reusable food pouch having a removably insertable one-way valve is disclosed herein. The one-way valve may be used with the reusable food pouch if food product having a water-like consistency is being stored in the reusable food pouch to prevent spills if the reusable food pouch is inadvertently laid on its side. Conversely, the one-way valve may be removed from the reusable food pouch if the food product has a consistency more like thick oatmeal and/or applesauce to allow for free flow of the food product through a spout of the reusable food pouch.
US10239644B2 Flat-bottom stand-up bag, vertical form, fill, and seal system and methodology for utilizing the same
A vertical form fill and seal system supports a sheet of material having material segments and a tube sized for drawing edges of the elongated sheet of material together in an overlapping configuration to form the sheet into a substantially tube shape. The VFFS also includes a sealer that seals the edges of the material to one another and a gusseting mechanism sized for forming a gusseted tuck in each of a left panel portion of the material and a right panel portion of the material. A cutting mechanism removes a first portion and a second portion of a first segment of the material segments in order to form a first cut and a second cut in the first segment and a sealing mechanism folds and seals the first segment at the first cut and at the second cut to provide an end wall with a substantially flat, rectangular-shaped footprint.
US10239643B2 Rigid holding container with breachable perimeter bubble
A rigid holding container has a flexible cover sheet extending over the holding area for sealing the contents. The container has a wide, flat perimeter lip which provides a firm base for the seal between the cover sheet and the container. A breaching bubble is formed in the seal, under the cover and over the perimeter lip. The consumer breaches the bubble by pressing the bubble against the lip between the thumb and forefinger. The pressure compresses the air in the bubble causing the bubble to expand laterally. The expanding bubble breaches along the perimeter of the lip, producing a peel flap of flexible cover material. The consumer pulls the peel flap while holding the rigid container down, to remove the cover sheet.
US10239642B1 Hinge and lock mechanism for roll-out solar array
A roll-out solar array includes a first mandrel having first and second ends and a second mandrel having first and second ends. A hinge extends between the first and second mandrels, such that the roll-out solar array can transition between a stowed position where the mandrels are in a substantially parallel configuration and a deployed position where the mandrels are in a series configuration. A latch may be provided to lock the roll-out solar array in the stowed configuration.
US10239638B1 Home station for unmanned aerial vehicle
Described herein are apparatuses that provided various features related to unmanned aerial vehicles (UAVs). An example apparatus may include, among other features, (i) a launch system for a UAV, (ii) a landing feature that is arranged on the apparatus so as to receive the UAV when the UAV returns from a flight, and (iii) a mechanical battery-replacement system that is configured to (a) remove a first battery from the UAV, and (b) after removal of the first battery, install a second battery in the UAV.
US10239634B2 OLED lighting for avionic keypanels
An illuminated keypanel includes an input device. The input device has control symbology. The illuminated keypanel also includes an organic light emitting diode (OLED) sheet. The OLED sheet provides illumination to the control symbology of the input device.
US10239633B2 System and method to interchange flight control inceptors in an aircraft flight control system and cockpit
A flexible flight control system enables conversion from one architecture using one type of inceptor to another architecture using another type of inceptor, through the usage of modular software and hardware pieces with common interfaces among the different types of inceptors. Longitudinal and lateral directional control laws are adapted to be compatible with the specific aspects of the operation of each configuration/architecture, giving the option to the aircraft operator to choose any one of a number of inceptor architectures at time of manufacture.
US10239630B2 Aircraft refueling safety system
A system ensures the correct type of fuel is dispensed in an aircraft while removing the introduction of human error in the refueling process. The system includes an RFID tag disposed at one or more aircraft that electronically stores data such as engine type, engine hours, fuel type, tail number, and pilot/subscriber data for the aircraft on which the RFID tag is disposed. An RFID reader is disposed at or near a fuel dispensing mechanism, such as a fuel truck or tank. A signal indicative of fuel type is emitted from the RFID tag to the RFID reader. RFID tags on aircraft that are enrolled in the system's subscription service enable aircraft to be recognized by a module operating the fuel dispensing mechanism. Based on a comparison performed by the module, authorization to begin fueling is either permitted or declined.
US10239629B2 Method and system for recycling motor power of a movable object
A method for recycling motor power includes controlling a first motor of an unmanned aerial vehicle (UAV) in a decelerating state to work in concert with a second motor of the UAV in an accelerating state to effect rotation of the UAV, receiving power from the first motor at a power bus in electrical connection with the first motor and the second motor, and providing a portion of the received power to the second motor through the power bus during the rotation of the UAV.
US10239623B2 Aircraft air conditioning system and method of operating an aircraft air conditioning system
An aircraft air conditioning system including a process air line having a first end connected to a process air source to allow a flow of process air therethrough. A ram air channel of the air conditioning system allows ambient air flow therethrough. A heat exchanger unit is disposed in the process air line and arranged within the ram air channel to thermally couple process air flowing through the process air line to ambient air flowing through the ram air channel. A water extractor disposed in the process air line downstream of the heat exchanger unit extracts water from the process air. A water supply system supplies extracted water into the ram air channel. The water supply system has a control arrangement to control a fluid connection between the water extractor and the ram air channel in dependence on an operating state of the aircraft air conditioning system.
US10239621B2 Aircraft seating network interface
A networked suite of aircraft-seat devices is disclosed, wherein the devices receive both power and network communications via the same terminal. The devices may be connected by a two-wire connection and may be configured in a daisy chain. Various aircraft seat devices, such as actuators, may be directly connected to the network or connected via control modules connected to the network. One device on the network may be designated as a master device for controlling network configuration. A method of automatically addressing network devices includes measuring a first quiescent current through the network, enabling an addressing current in unaddressed devices, and measuring the change in current at each device after enabling the addressing currents to determine the last device in the chain.
US10239617B2 Oxygen box for a limited maintenance access area above a ceiling panel of an aircraft cabin
An oxygen box is secured in an oxygen box hole through a panel of an aircraft cabin by fasteners that are positioned in an interior volume of the oxygen box and are inserted through holes in a back wall of the oxygen box that are aligned with fastener openings in an exterior bracket positioned behind the panel and behind the oxygen box opening where the fasteners are received by the fastener openings in the exterior bracket and the fasteners removably attach the oxygen box to the exterior bracket.
US10239611B2 Hybrid multicopter and fixed wing aerial vehicle
An aerial vehicle is includes a wing, first and second rotors, and a movement sensor. The first and second multicopter rotors are rotatably coupled to the wing, the first multicopter rotor is rotatable relative to the wing about a first lateral axis, and the second multicopter rotor is rotatable relative to the wing about a second lateral axis. Each multicopter rotor is coupled to each other multicopter rotor, wherein the multicopter rotors are restricted to collective synchronous rotation relative to the wing between a multicopter configuration and a fixed-wing configuration. The movement sensor is coupled to the multicopter rotors, wherein the movement sensor is positioned to rotate relative to the wing when the multicopter rotors rotate relative to the wing between the multicopter and fixed-wing configurations.
US10239610B2 Compact linear hydraulic actuator
In some embodiments, an actuator includes a chamber, a piston disposed within the chamber, and a tube. The chamber has a first port and a second port. The piston comprises a first surface, a second surface, and an elongated conduit coupling the first surface to the second surface. The first surface is disposed between the first port and the second port. The second surface is offset from the first surface. The tube is disposed at least partially within the elongated conduit of the piston. The tube comprises a third port disposed within the elongated conduit of the piston and a fourth port disposed outside of the elongated conduit of the piston.
US10239608B2 Aircraft landing gear
The invention relates to an aircraft landing gear (2) comprising: —a leg (6) that can be pivotably connected to a load-bearing structure of the aircraft (1) in order for the landing gear (2) to be deployed and retracted; —a wheel (13, 14) that is rotatable in relation to the leg (6), and an electric motor (15, 16) that can rotate the wheel (13, 14) in relation to the leg (6); —a transmission mechanism (17) designed to selectively transmit torque generated by the electric motor (15, 16) to the wheel (13, 14) in order to rotate the wheel in relation to the leg (6) or to the leg (6) in order to rotate the leg (6) in relation to the load-bearing structure of the aircraft (1) in order to deploy or retract the landing gear (2).
US10239606B2 Airflow interrupting devices
A flow interrupting device may cause a flow to separate from a wingtip device at a desired angle of attack. The flow interrupting device may be coupled to a leading edge of a wingtip device where a flow disruptor may be configured to alleviate a load on the wingtip device. The flow disrupter may comprise an edge that extends into a boundary layer at a threshold angle of attack that may disrupt the boundary layer and cause a flow to separate from the wingtip device. This separated flow may reduce stresses experienced by the wingtip device and wing during various flight conditions where a transverse flow is encountered.
US10239605B2 Chordwise folding and locking of rotor systems
An apparatus for chordwise folding and locking of rotor systems includes a grip assembly and a harness disposed at least partially within and coupled to the grip assembly. A rotor blade is rotatably coupled to the grip assembly and the harness. The rotor blade has a radially extended orientation and a stowed orientation. A linkage assembly has a first end, a second end and a pivot joint therebetween. The first end of the linkage assembly is rotatably coupled to the harness and the second end of the linkage assembly is rotatably coupled to the rotor blade. A first lock assembly selectively secures the rotor blade to the grip assembly and the harness when the rotor blade is in the radially extended orientation. A second lock assembly selectively secures the rotor blade relative to the harness when the rotor blade is in the stowed orientation.
US10239604B2 Structurally biased proprotor blade assembly
A tiltrotor aircraft includes a fuselage, a wing member extending from the fuselage, an engine disposed relative to the wing member and a proprotor mechanically coupled to the engine. The proprotor includes a plurality of proprotor blade assemblies each including a spar and a sheath extending spanwise along the spar forming the leading edge of the proprotor blade assembly. The spar has a root section, a main section and a tip section. The spar has a generally oval cross section at radial stations along the main section and a first edge having a structural bias relative to a generally oppositely disposed second edge at the radial stations along the main section.
US10239600B2 Marine propulsion assembly utilizing a dual opposed threaded drive shaft with taper
A marine propulsion assembly includes a propeller having a threaded hub whose threads are used for engaging with a drive shaft. The drive shaft includes both a first set of threads and second set of threads such that the first set of threads are used to engage with a keeper nut and a second set of threads are used to engage within the propeller hub. The first set of threads are configured to be opposite the direction of propeller rotation for preventing rotation of the keeper nut while the second set of threads are configured opposite the direction of rotation of the propeller to prevent the propeller from loosening on the drive shaft. The drive shaft further includes a tapered section for providing a stop to the propeller when engaging with the second set of threads.
US10239598B2 Cooling system for an outboard motor having a hydraulic shift mechanism
An outboard motor having an internal combustion engine that causes rotation of a driveshaft, a planetary transmission that operatively connects the driveshaft to a transmission output shaft, a band brake configured to shift the planetary transmission amongst a forward gear, neutral gear and reverse gear, a hydraulic actuator is configured to actuate the band brake, and a cooling water circuit that extends adjacent to the hydraulic actuator so that the hydraulic actuator exchanges heat with cooling water in the cooling water circuit.
US10239593B2 Fender with built-in fender cover using flocked material
A boat fender includes a vinyl fender core that is sized and shaped for suspension adjacent a boat exterior to protect the boat exterior from damage resulting from impact with an obstacle. An integrated cover is secured to the fender core, such as by flocking.
US10239592B1 Boat keel guard
A keel guard is comprised of a strip of PVC material having a length and a width. An alignment section is positioned along the length of the strip that is visible through the PVC material. The alignment section, which may be a groove for engaging the keel, facilitates installation and enables the installer to maintain the desired straightness along the entire installed length. Additionally, the see-through PVC material reveals any trapped air bubbles between the keel guard and the hull, enabling the are bubbles to be more easily removed, thereby providing a stronger, more uniform bond.
US10239591B1 Surf wake forming systems and methods employing primary subtab and secondary subtab
A wakeboat has a hull, the hull forming a wake when moving forward in the water, with a port disturbance and a starboard disturbance in the wake. A trim tab is supported by the hull at the stern of the hull. The trim tab comprises a primary subtab and a secondary subtab. One or more actuators may be optionally included to reposition the trim tab more into, or more out of, the water. Other systems and methods are also provided.
US10239590B2 Suction stabilized floats
Floats having a buoyant portion and a chamber portion hold liquid within their chambers above the interface of the surrounding body of liquid and gas which creates a downward force which stabilizes the float. If the liquid is water, the float holds water in the inner chamber which is disposed above the waterline of the body of water in which the float is suspended. The elevated water exerts a downward force that acts against rocking, swaying, and other destabilizing forces.
US10239589B2 Under seat caddy for marine craft
A storage caddy system for mounting underneath a seat has a mounting bracket for attachment between a bottom of the seat and at least one leg, and a storage caddy removably attached to the mounting bracket. The storage caddy has at least one storage compartment for storing an item, which is accessible by at least one access point in an outer wall of the storage caddy. The storage caddy is configured to allow movement of the seat relative to the leg. The storage caddy is slidable relative to the mounting bracket in a direction perpendicular to the leg from a partially stowed position to a fully stowed position.
US10239588B2 Water vehicle having a crane for lifting loads
A watercraft may include a crane for lifting loads. The crane may include a tower and a boom that is rotatble with respect to the tower. The tower may be positioned inside the outer contour of the watercraft so as to minimize the profile of the watercraft on radar. The watercraft may include a superstructure within which the tower may be disposed. The superstructure may include planar outer walls that are obtuse relative to a horizontal plane. A rotary bearing may be utilized to connect the boom to the tower and permit the boom to rotate relative to the tower. Further, when the boom is in a rest position, a lower edge of the boom may be positioned 10 cm or less above the crane deck.
US10239587B1 Buoy storage system
A buoy storage system for storing buoys on a boat includes a plurality of buoys that is each employed on a boat. A plurality of baskets is provided and each of the baskets is mounted on a deck of the boat such that each of the baskets is accessible to a user. Each of the buoys is removably positioned in an associated one of the baskets for storage and each of the buoys is vertically oriented in the associated basket.
US10239586B1 Pool noodle with drink holder
A pool toy consists of a flexible, buoyant pool noodle with a drink holder mounted to one end. A user sits on or astride the noodle in a well-known manner to float relaxingly in a generally upright posture in a pool, lake, or other body of water. The weight of the user on the flexible noodle causes the noodle to bend into a substantially U-shaped configuration, in which at least one end of the pool noodle projects above the surface of the water. The drink holder is mounted to an end of the pool noodle that is located above the surface of the water, providing a handy location to hold a beverage container.
US10239583B2 Covering system
A covering system for removably covering a vehicle, such as a boat, that includes a plurality of rotatively anchored swing arms rotatable between a covered position and an uncovered position. Each swing arm includes a mount and a pretensioner formed of one or more stays adjustably attached to part of a shaft of the arm to adjust an applied preload and transfer forces encountered during operation to part of the shaft rotatively anchored by the mount to a grounded structure such as a piling or post of a dock. The swing arms are pivotally connected to an elongate transversely extending carriage from which a cover is suspended with a boom of each arm connected to the carriage by a pivot assembly that also facilitates carriage and cover position adjustment. A pivot limiter can be included that limits or even stops pivoting of the carriage relative to the swing arm boom.
US10239581B2 Bicycle brake and shift lever assembly
A shift and brake lever assembly including a brake lever having a first surface facing a handlebar and a second surface facing away from a handlebar. A shift lever may be mounted to the second surface of the brake lever using mounting components. Complementary apertures of the various mounting components may lie on a common longitudinal axis.
US10239579B2 Bicycle electric rear derailleur
A bicycle electric rear derailleur that has a support body configured to be mounted on a bicycle frame at an assembly of wheels coaxial with a hub of a rear wheel of the bicycle, a movable body, having a chain guide and linkage between the movable body and the support body. The linkage between the movable body and the support body comprises an inner connecting rod and an outer connecting rod. The ends of the rods are articulated to the support body and to the movable body to form an articulated parallelogram. A battery power supply unit is supported by one of the inner connecting rod and the outer connecting rod.
US10239576B2 Front wheel drive bicycle assembly
A front wheel drive bicycle assembly includes a frame that may be mounted for riding. A front wheel is rotatably coupled to a front end of the frame and the front wheel rolls along a support surface. A pedal unit is rotatably coupled to the frame and the pedal unit is selectively pedaled. The pedal unit is in mechanical communication with the front wheel to rotate the front wheel thereby urging the frame along the support surface. A rear wheel is rotatably coupled to a back end of the frame and the rear wheel rolls along the support surface. Moreover, the rear wheel is selectively rotated about a vertical axis for steering. A steering unit is movably coupled to the frame and the steering unit is in mechanical communication with the rear wheel. In this way the steering unit selectively rotates the rear wheel about the vertical axis for steering.
US10239570B2 Device and method for performing tilt compensation by rotating arms
A tilt management device configured to perform tilt correction. The device measures a direction of tilt using a tilt sensor. Circuitry rotates connected arms to compensate for the measured tilt by modulating a center of mass of the device.
US10239562B2 Vehicle
A vehicle with a passenger area having a seat disposed therein and an opening of the passenger area on the right or left sides of the seat. The vehicle frame includes an opening frame portion defining the opening of the passenger area. The opening frame portion comprises a lower attachment portion for attaching a hinge of a first door to the opening frame portion, and an upper attachment portion for attaching a hinge of a second door to the opening frame portion. The lower attachment portion and the upper attachment portion are portions formed by at least one of machining and welding. The lower attachment portion is formed in the main body frame of the vehicle frame, and the upper attachment portion is formed in the case of the vehicle frame.
US10239560B2 Subframe for vehicle
There is provided a vehicle subframe (1) in which a projecting portion (24, 31) of a front member (20) extends upward, while projecting from a body portion in a width direction, to have an upper end (25, 32), and exhibits a convex shape toward a front side, with the upper end (25, 32) functioning as a front attachment portion to a vehicle body, in such a manner that support stiffness of a suspension can be improved, while ensuring favorable productivity, high strength, and the like, with a simple configuration.
US10239559B2 Vehicle frames and methods of assembling the same
A vehicle frame is provided. The vehicle frame includes a body frame, a subframe mounted to the body frame, and a bumper frame coupled to the body frame. The bumper frame includes a beam having a first end and a second end. The vehicle frame also includes at least one brace coupling the beam to the subframe adjacent to at least one of the beam ends.
US10239557B2 Vehicle travel control device and autonomous driving control method
A vehicle travel control device includes: an EPS device turning a wheel of a vehicle; and a control device performing autonomous driving control that controls autonomous driving of the vehicle. The autonomous driving control includes: calculating a target steering angle of the wheel; and actuating the EPS device to turn the wheel such that a steering angle of the wheel becomes the target steering angle. Calculating the target steering angle includes: calculating an autonomous driving steering angle and a target state quantity required for automatic steering in the autonomous driving; calculating a counter steering angle required for vehicle stabilization control, based on the target state quantity without using a steering wheel angle; and calculating a sum of the autonomous driving steering angle and the counter steering angle as the target steering angle.
US10239543B2 Vehicle cooling system and corresponding operating method
A vehicle cooling system may include a cooling circuit for cooling at least one main component of a vehicle. The cooling circuit may include at least one cooler through which cooling air is flowable and at least two fan chambers adjoined to an outlet side of the at least one cooler. The at least two fan chambers may each include a respective fan arranged therein, a respective main outlet and a respective ancillary outlet. The vehicle cooling system may also include at least one waste air channel that may be connected to the respective ancillary outlets of the at least two fan chambers. The vehicle cooling system may further include at least one control device configured to control a cross-section of each of the respective ancillary outlets and to enable operation of the vehicle cooling system in a normal operating state and in at least two emergency operating states.
US10239537B2 Vehicle traveling control apparatus
A vehicle traveling control apparatus of the invention stops a vehicle by causing a braking force applying device to apply a braking force to the vehicle after determining that a driver is under an abnormal state. When a stop of a control for maintaining a vehicle at a stopped state is requested while a shift lever is set at a range other than parking and neutral ranges, the apparatus limits a driving force requested for a driving force supplying device to supply to drive wheels, to a value smaller than a driver's requesting driving force.
US10239534B2 Method and system for auxiliary power generation
An auxiliary power system for a motor vehicle includes a power generator that generates electricity to charge one or more auxiliary power system batteries. The motor vehicle includes an engine and drive train that distributes power from the engine to the drive wheels. The drive train can include a transmission, a drive shaft and a differential that connects the engine to the drive wheels. The power generator can be connected to the drive train (e.g., the transmission, the drive shaft or the differential) to draw power to generate electricity as well as to apply braking loads on the drive wheels to increase the ability to stop the motor vehicle.
US10239533B2 Method and device for anticipatory or predictive economical running of a motor vehicle including a determination of a route and a probable driving time and time of arrival
A method for anticipatory or predictive operation of a motor vehicle having a drive control system by which drive-relevant components of the drive-train are adjusted, and a detection system by which a travel route and anticipated driving time to a specified destination as well as the current position of the vehicle are determined. By way of the detection system and based on topographical information, a driving resistance profile of the route is prepared, to parameterize the drive control system such that the route is driven in a specifiable manner. If a need arises during the journey, a nominal arrival time or a travel route is specified or modified and, in accordance with the specified or changed nominal arrival time or route, the drive control system is dynamically re-parameterized so that the vehicle reaches its destination at the time concerned with regard to an efficient mode of operation.
US10239532B2 Method for operating a driver assistance system, and driver assistance system
A method for operating a driver-assistance system for the lateral guidance of a motor vehicle in a lane change from a current lane to a target lane in a traffic-lane split. Also provided is a driver-assistance system for the lateral guidance of a motor vehicle in a lane change from a current lane to a target lane in a traffic-lane split. The driver-assistance system encompasses a trajectory-ascertainment device, which is configured to ascertain a trajectory for the lane change of the motor vehicle from the current lane to the target lane so that the lane change from the current lane to the target lane is carried out at a predefined point in time following the traffic-lane split.
US10239530B2 Vehicle control apparatus for a regenerative braking system based on the battery input power
A vehicle control apparatus is a vehicle control apparatus controlling a vehicle and provided with a regenerative device generating electric power while applying a regenerative braking force by performing regenerative electric power generation, an electric power supply capable of exchanging electric power with the regenerative device, and a hydraulic device applying a hydraulic braking force attributable to a hydraulic pressure, and is provided with an electronic control device controlling the regenerative device and the hydraulic device so as to adjust the ratios of the regenerative braking force and the hydraulic braking force to a required braking force required for the braking of the vehicle based on an input electric power value input into the electric power supply.
US10239522B2 Inter-vehicle control apparatus
In an inter-vehicle control apparatus, a controller performs acceleration control of an own vehicle, based on an actual inter-vehicle physical quantity and a target inter-vehicle physical quantity. A limiter sets a limit value for a target jerk during the acceleration control. A detector detects an occurrence of at least one of: an event in which the inter-vehicle distance becomes discontinuously shorter; and an event in which a target inter-vehicle distance corresponding to the target inter-vehicle physical quantity becomes discontinuously longer. A determiner determines a risk of collision with the preceding vehicle, based on an operation state of the preceding vehicle in relation to the own vehicle. When at least one of the events is detected, the limiter sets the limit value to a value based on the risk of collision such that change in deceleration of the own vehicle is kept lower as the risk of collision decreases.
US10239520B2 Parking assistance device and parking assistance method
A parking assistance device according to an embodiment includes a determination unit that determines, when the parallel parking of a vehicle in a parking area is assisted, whether the parking space length of a frontage that the vehicle enters in the parking area is the sum of the full length of the vehicle and a certain length or more and a control unit that performs parking assistance for the vehicle along a route in which stationary steering control is not performed at a turning position of the vehicle when the parking space length is the sum of the full length of the vehicle and the certain length or more.
US10239513B2 Method for gear shifting in a hybrid vehicle
A method for obtaining gear shifting of a vehicle, where the vehicle has a planetary gearing in the drive train, a combustion engine with an output shaft connected to a rotor of a second electric machine and to a first component of the planetary gearing, a first electric machine with a rotor connected to a third component of the planetary gearing and an input shaft of a gearbox connected to a second component of the planetary gearing. The method is started with the components of the planetary gearing interlocked by a locking means, in which they are released during the gear shifting and interlocked again after the gear shifting has been carried out.
US10239511B2 Hydraulic pressure generation apparatus
One embodiment provides a hydraulic pressure generation apparatus including: a base body; a motor; a reservoir tank; a master cylinder which generates a brake hydraulic pressure by a brake manipulator; and a slave cylinder which generates a brake hydraulic pressure the motor. The base body includes: a first cylinder hole which is a bottomed cylinder hole, and in which the first piston is inserted; a second cylinder hole which is a bottomed cylinder hole, and in which the second piston is inserted; and a supply passage which leads from the reservoir tank to a hydraulic chamber of the slave cylinder. The supply passage is provided with a check valve which permits only inflow of brake fluid from the reservoir tank to a side of the slave cylinder, near a brake fluid discharge port of the second cylinder hole.
US10239510B2 Method for controlling a hydraulic brake system of a motor vehicle
A method of controlling a brake system of a motor vehicle having a braking assistance function. The brake system including a master brake cylinder, activated with a brake pedal. A distance s between a valve piston connected to the brake pedal, and a transmission element, connected to a pressure piston of the master brake cylinder is sensed and the brake system is controlled as a function of the sensed distance s. Within the scope of this monitoring process, brake pedal release is detected even when the pressure-generating unit is activated. In addition, despite an active braking assistance function, consistent interplay occurs between activation by the driver and assistance-side activation of the brakes given satisfactory pedal feedback.
US10239507B2 Vehicle brake hydraulic pressure control apparatus and road surface friction coefficient estimating device
One embodiment provides a vehicle brake hydraulic controller including: an antilock braking controlling module configured to perform an antilock braking control in which a brake hydraulic pressure applied to wheel brakes is reduced under the condition that a slip-related amount has reached a pressure reduction threshold value; and a turning judging module configured to judge whether a vehicle is turning based on a steering angle, wherein, when the antilock braking control is performed and in the case that the turning judging module judges that the vehicle is turning, the antilock braking controlling module performs a turning pressure reduction control so as to: change the pressure reduction threshold values to be more easily reached by the slip-related amount than at the time of straight running; and change the pressure reduction amounts to be larger than that at the time of straight running.
US10239503B2 Method for providing the application force generated by a parking brake
In a method for providing the application force generated by a parking brake, which is at least partially generated by an electromechanical brake device having an electric brake motor, a retensioning process is terminated in the event that (i) the motor current exceeds a limit value or (ii) the rotational speed of the motor drops below a limit value.
US10239497B2 Mounting structure for water blocking cap in wiper device, method for mounting water blocking cap, and wiper device
A mounting structure for a water blocking cap is adapted to a wiper device that includes a shaft holder and a water blocking cap. The shaft holder includes a stem and a fixed portion. The water blocking cap includes a mounting portion and a water receiver. One of the shaft holder and the water blocking cap includes a guide portion that moves the water blocking cap in a direction intersecting with the axial direction of the stem. In a mounted state in which the mounting portion is mounted to the stem, a part of the water receiver is arranged in a position that is closer to the proximal side of the stem than the fixed portion and in which the part overlaps with the fixed portion as viewed from the axial direction of the stem.
US10239496B2 Wiper blade assembly protector and method of protecting a wiper blade assembly
A protector for a windshield wiper assembly includes an elongated body defining a cavity receiving at least the blade of the wiper assembly. The cover is used to protect the assembly from snow, ice, mud, etc. Preferably, the assembly is pivoted away from the windshield before the blade is inserted into the body. Caps with decorative covers are provided at the ends of the body. The body may be made of a translucent material and may be covered with logos, insignia and other advertising materials.
US10239494B2 Secure vehicle access system, key, vehicle and method therefor
A secure vehicle access system comprises a vehicle and a key associated with the vehicle. The key comprises: a radio frequency, RF, key transceiver configured to: broadcast at least one signal; and listen for an acknowledgement message from the vehicle. The vehicle comprises: a radio frequency, RF, vehicle transceiver configured to: listen for the at least one broadcast signal from the key; and in response thereto, transmit an acknowledgement message back to the key to establish a communication link between the vehicle and the key. The key further comprises a ranging circuit configured to perform a distance determination between the vehicle and the key, following the establishment of the communication link, to determine whether to allow access to the vehicle.
US10239492B2 Wireless authentication device for saddle-type vehicle
A wireless authentication device for a saddle-type vehicle performs authentication through wireless communication with a mobile terminal carried by a user. The wireless authentication device for a saddle-type vehicle includes a first operating input device, a light-emitting and notification part, and a controller. The first operating input device receives an operation of switching to a state in which a power engine is capable of being started. The light-emitting and notification part is provided in the first operating input device or in a portion surrounding the first operating input device, and performs a light-emitting and notification operation in which light is emitted to notify a user that authentication has succeeded. The controller determines whether authentication has succeeded through wireless communication with a mobile terminal, and if the authentication has been determined to have succeeded, causes the light-emitting and notification part to perform the light-emitting and notification operation.
US10239489B2 Vehicle access system with inadvertent actuation control
In at least some implementations, a method for preventing inadvertant operation of a vehicle access system that includes a plurality of inputs involves providing a keypad operable to output signals to control a vehicle system based on entry of a code via the inputs, detecting when a predetermined access sequence is inputted via the inputs and outputting a signal to a vehicle system to allow access to the vehicle, and operating the keypad in a disabled mode wherein the keypad output signals are not outputted. The disabled mode may be activated either actively or passively or both, and the disabled mode may be terminated either actively or passively or both.
US10239488B2 Column housing for vehicle steering system
A column housing for a vehicle steering system is made of synthetic resin and coupled outside a column tube of a steering column for the vehicle system, the column housing including: a slit which is formed to be elongated in a predetermined direction so that the column housing is deformed inward when the column housing is pressed on and fixed to the column tube positioned inside the column housing; and a first reinforcing portion which is formed so as to protrude outward at a predetermined portion from an end position of an end portion of the slit to the periphery of the slit where the slit is not formed, and has a shape having an increased thickness relative to other portions of the column housing.
US10239487B2 Sensor device and device for checking the operational condition of a harness of a safety seat
A device for controlling the correct operating state of a restraining harness, intended for a safety seat, including at least one retaining strap that is under tension when the harness is in the state of restraining the occupant, the device being intended to be disposed in a predefined area of the latter, the device including: at least one sensor device including an elongate flexible element that is suitable for being positioned on the strap, and in particular rigidly connected thereto in the predefined area, and that is provided with a measuring system to measure, in the predefined area, at least a level of bending and/or tilting of the strap, a device to collect values linked to the level of bending and/or tilting, and internal or external device configured to analyze the values and of communicating with a receiver for receiving information on the operating state of the retaining harness.
US10239483B2 Gas generator and assembling method thereof
A gas generator includes, a housing with a gas discharge port, an igniter assembly and a gas generating agent in the housing; and a metallic cup of constant inner diameter covering the igniter to define a charging chamber. The igniter assembly includes a main body, including an ignition portion and an electro-conductive pin integrated with a metallic collar by a resin. The metallic collar has a fixing portion inserted into a hole in a bottom surface of the housing and a remaining portion projecting inward from the bottom surface of the housing, and a guide portion. An inner circumferential wall surface of the metallic cup and an outer circumferential wall surface of the fixing portion are press-fitted, and an annular gap is formed between the inner circumferential wall of the metallic cup member and an outer circumferential wall surface of the guide portion.
US10239482B2 Method for folding an airbag, and airbag module
A method for folding an airbag includes folding the airbag into an elongate state at least partially by roll-folding. The method also includes inserting a gas generator and/or an airbag-retaining metal sheet into the airbag. The gas generator and/or the airbag-retaining metal sheet is/are located in the central third of the airbag folded in elongate shape so that two end portions of the airbag project from the gas generator and/or from the airbag-retaining metal sheet. The method also includes guiding the airbag end portions around the outer circumference of the gas generator and/or of the airbag-retaining metal sheet in opposite directions toward each other up to a folding zone in which the end portions of the airbag at least almost contact each other. The method further includes folding over the end portions of the airbag from the folding zone outwards and guiding the airbag end portions in the opposite direction around the outer circumference of the gas generator and/or of the airbag-retaining metal sheet and around internal parts of the airbag end portions located thereon for forming external parts.
US10239480B2 Displaceable steering wheel safety systems and related methods
Apparatus, methods, and systems for repositioning a steering wheel and/or airbag cushion prior to and/or during deployment of the airbag cushion resulting from an impact event. Some embodiments may comprise a steering wheel configured to be positioned between a first, operational configuration and a second, deployed configuration at least in part by a translational movement of the steering wheel. An airbag cushion may be deployable from the steering wheel and may be configured to move from the first configuration to the second configuration before or during deployment of the airbag cushion.
US10239478B2 Four-quadrant protective dent shield system
A deployable dent shield assembly for a vehicle includes a deployable dent shield element adapted for translation between a stowed position comprising a coiled configuration disposed below a vehicle element and a deployed position overlaying at least a portion of a vehicle door and/or fender. The dent shield assemblies may be manually-operated or power-operated.
US10239476B2 System for inhibiting operation of a vehicle-based device while the vehicle is in motion
A system for inhibiting operation of a vehicle-based device while the vehicle is in motion includes a motion sensor, a timer, and a time delay override switch in communication with a control circuit. The control circuit selectively outputs one or more enable and/or inhibit signals based on the states of the motion sensor and timer. The time delay override switch can be actuated to place the timer into a timed out state from a timing state.
US10239472B2 Automotive door-hole-sealing material
An automotive door-hole-sealing material reduces noise to be generated by contact between the sheeted foam elastic material and the protrusion, and, moreover, improves quietness inside the passenger compartment with high sound absorption performance and sound insulating effect. The automotive door-hole-sealing material 1 includes a resin sheet 2, and a sheeted foam elastic material 3. The resin sheet 2 has a through hole 2c formed in association with a protruding end of the impact absorbing material 105. In a side view, the sheeted foam elastic material 3 has a portion relaxing within an inner periphery of the through hole 2c of the resin sheet 2.
US10239469B2 Cameras and camera housings for vehicle trailers
Apparatus are disclosed for cameras and camera housings for vehicle trailers. An example camera housing for vehicle trailers includes a first body defining an aperture and a second body coupling to the first body to define a cavity. The example camera housing also includes a panel that slides along the first body toward an open position to expose the aperture as the cavity receives a camera and toward a closed position to cover the aperture as the camera is removed. The example camera housing also includes a spring biasing the panel toward the closed position.
US10239468B2 Method of attaching vehicle-mounted camera
A method of attaching a vehicle-mounted camera includes assuming in advance a plurality of inclination angles as inclination angles of a glass surface, assuming in advance a plurality of positioning angles smaller in number than the plurality of inclination angles, specifying an inclination angle of the glass surface of a vehicle body to which the vehicle-mounted camera is to be attached, selecting at least one positioning angle from the assumed plurality of positioning angles and preparing a positioning member having the selected positioning angle, and fixing the vehicle-mounted camera to the glass surface of the vehicle body via the prepared positioning member.
US10239465B2 Method and system for carrying a bicycle on a vehicle
A vehicle-mounted bicycle carrier allows a bicycle to be mounted to the carrier in a ride-ready fashion, without the need to remove one of the bicycle wheels, and permits the reversible securement of both wheels simultaneously by a simple single pivotal movement of a tire retention loop.
US10239464B1 Wheel stabilizing assembly for a pick-up truck
A wheel/tire stabilizing assembly that can be removably mountable to a rear (or other) wall of a pickup truck bed is presented herein. The assembly can be used to facilitate the hauling of a wheeled vehicle (e.g., a motorcycle or bicycle) in the pickup truck bed, for example, by engaging or receiving one or more wheels/tires for stabilization. The assembly includes a wheel bracket and a mounting clamp adjustably interconnected or fastened to one another which can be clamped to the support surface. The mounting clamp may be moved or adjusted relative to the wheel bracket to fit or clamp to support surfaces having different widths or dimensions. The wheel bracket includes a pair of extension arms extending outward in a laterally spaced relation to one another defining a wheel receiving space.
US10239455B2 Reactive smart rear view display mirror
A motor vehicle includes a driver sensor detecting a position of a human driver of the motor vehicle. A rear view camera captures images of an environment behind the motor vehicle. A display screen is disposed within a passenger compartment of the motor vehicle. An electronic processor is communicatively coupled to each of the driver sensor, the rear view camera, and the display screen. The electronic processor receives images captured by the rear view camera, receives outputs of the driver sensor, determines a position of the driver's head or eyes dependent upon the outputs of the driver sensor, and transmits video signals to the display screen. The video signals are dependent upon the determined position of the driver's head or eyes and dependent upon images captured by the rear view camera.
US10239452B1 Minimizing false collision avoidance warnings
A route learning system for a vehicle and a method of using the system is described. The method includes: in response to determining that a current location matches a historical location, retrieving from memory false alert geotag that includes historical path data; and based on determining that a currently-predicted path does not match the historical path, replacing the currently-predicted path with the historical path to mitigate a false warning to a driver of a host vehicle.
US10239450B1 Collision avoidance and/or pedestrian detection system
A collision avoidance and/or pedestrian detection system for a large passenger vehicle such as commuter bus, which includes one or more exterior and/or interior sensing devices positioned strategically around the exterior and interior of the vehicle for recording data, method for avoiding collisions and/or detecting pedestrians, and features/articles of manufacture for improving same, is described herein in various embodiments. The sensing devices may be responsive to one or more situational sensors, and may be connected to one or more interior and/or exterior warning systems configured to alert a driver inside the vehicle and/or a pedestrian outside the vehicle that a collision may be possible and/or imminent based on a path of the vehicle and/or a position of the pedestrian as detected by one or more sensing devices and/or situational sensors.
US10239445B1 Projection assembly for a vehicle
A safety projection assembly including a housing comprising top, bottom, front, rear, and side portions that at least partially surround and at least partially define a cavity, the bottom portion of the housing is connected to at least a portion of the vehicle; and a projection mechanism at least partially received within the cavity of the housing, the projection mechanism is configured to project an image or a series of images onto at least a portion of the vehicle or an operator thereof.
US10239444B2 User-configurable indication device for use with an on-demand transport service
A system and method for configuring an indication device is described. An on-demand service system arranges a service for a user to be provided by a service provider. The system determines whether the user has specified an output configuration for an indication device in an account of the user. In response to determining that the user has specified an output configuration for the indication device, the system identifies data corresponding to the output configuration and transmits the data to a mobile computing device of the service provider to enable the mobile computing device to control the indication device of the service provider based on the data.
US10239441B2 Illumination device for a motor vehicle
An illumination device for a motor vehicle includes a light source constructed of a number of semiconductor diodes, and an optical device for generating a predefined light distribution from the light of the light source. The optical device is arranged in a housing. The illumination device is characterized in that the light source is rigidly connected to the housing. At least one optical waveguide is provided for guiding the light of the light source to the optical device.
US10239436B2 Trailer-mounted proppant delivery system
An apparatus and process for delivering proppant to a well site has a trailer with a bed thereon and at least one track of rollers extending in parallel relationship to the longitudinal axis of the trailer. The track of rollers extend substantially for an entire length of the bed of the trailer. At least one proppant container is translatably positioned on the track of rollers. The proppant container is movable along the array of rollers from one end of the bed to an opposite end of the bed. A bin can be removably positioned below the bed of the trailer in a position rearward of the front end of the trailer and forward of a rear end of the trailer so as to allow the proppant container to discharge into the bin. A conveyor is cooperative with the bin so as to move proppant from the bin to a location at the well site.
US10239435B2 Locking arm system for a retention ramp of a lift gate
The present invention provides a locking assembly for a ramp of a lift gate. The locking assembly comprises an elongated locking arm and a spring for spring loading the locking arm. The locking arm is pivotably disposed on a pivot point relative to the ramp. A biasing tension in the spring urges a proximal end of the locking arm to engage with a cam portion of the ramp to maintain the ramp in a selected position. The cam portion has multiple engagement surfaces for individually engaging with the locking arm, wherein selectively engaging the locking arm with each engagement surface of the cam portion maintains the ramp in a corresponding selected position.
US10239433B2 Headrest and method for assembling a headrest
A headrest (1) for a vehicle includes a main element (2) on which a wing element (3) is mounted by means of a hinge (4) so as to be rotatable about a substantially vertical axis. So as to create a frictional locking function, the hinge (4) includes a shaft (41) with a projection (43) as well as a bush (42) with a receptacle (44) that is associated with the projection (43). The shaft (41) is mounted in the bush (42), and in a locked position the projection (43) engages into the receptacle (44).
US10239431B2 Cross-tube attachment hook features for modular assembly and support
A vehicle seating assembly includes a seat. An attachment bracket is coupled to an underside of the seat and includes forwardly-extending hook features. Each hook feature defines a receiving aperture to receive a front cross-tube. A polymeric overmold is disposed over each hook feature. A downwardly-extending retention member is disposed between the hook features. Rear support hooks are configured to engage a rear cross-tube of the seat as a seat carrier is rotated downwardly into position during manufacture.
US10239427B2 Vehicle seat with foldable stow position
A foldable vehicle includes a seat base, a seatback connected to the seat base for pivotal movement relative to the seat base from a generally vertical use position to a generally horizontal stow position atop the seat base, wherein the seat base is pivotally connected to the floor such that, when the seatback is moved from its use position to the folded, stow position, the seat base may be moved rearward and downward to thereby provide a lower load floor position. The seat also includes a lock mechanism to engage and lock the seat base in a first position when the seatback is positioned within the defined range of use positions, and unlock the seat base for movement to a second position when the seatback is positioned outside the use range.
US10239421B2 Vehicle seat
A vehicle seat in which a swiveling motion of a sub-frame is restricted only to a desirable direction is provided. A sub-frame is suspended from a seatback frame. A first elastic member connects a right upper end of the sub-frame to the seat back frame, and a second elastic member a left upper end of the sub-frame to the seat back frame. A universal joint mechanism connects a lower lateral portion of the sub-frame to a lateral member of the seat back frame.
US10239417B2 Vehicle
An electronic control unit performs a control routine including a step of setting SOC_u(1) as an upper limit value of an SOC and a step of setting SOC_l(1) as a lower limit value when a battery temperature TBs is higher than a first threshold value TBs(1) and a step of setting SOC_u(2) as the upper limit value and a step of setting SOC_l(2) as the lower limit value when the battery temperature TBs is lower than a second threshold value TBs(2).
US10239416B2 System and method for improving reverse driving capability of electrified vehicles
A method includes controlling an electrified vehicle by modifying a state of charge (SOC) window associated with an energy storage device of the electrified vehicle in response to a reverse driving event or a trailer towing event.
US10239414B2 Information providing system, power receiving device, information providing method and information providing program
According to an embodiment, an information providing system for providing information about a wireless power transfer system including a power receiver mounted on a moving object and one or more power transmitters installed in one or more charging stations includes a search unit configured to extract location information of a charging station in which a power transmitter capable of feeding power to the power receiver is installed, by referring to a station storage unit that stores station information indicating correspondence between the location information of the charging station and the power transmitter of the charging station and to a history storage unit that stores a usage history indicating one or more power transmitters previously used by the power receiver, and an output unit configured to output the location information of the charging station extracted by the search unit.
US10239412B2 Method and apparatus for wireless charging using variable switching frequency
A wireless charging method performed by a wireless power receiving apparatus for a vehicle includes: producing a resonance between a primary pad located outside of the vehicle and a secondary pad installed in the vehicle based on an initial switching frequency; and tuning a switching frequency of a direct current (DC) to DC (DC-to-DC) converter within a range determined based on the initial switching frequency, according to an output voltage outputted based on a resonance of the secondary pad which is caused by the primary pad.
US10239410B2 Method and arrangement for charging a vehicle battery
A method for charging a vehicle battery which stores electrical power for an electrical drive motor of a vehicle, wherein the vehicle battery is electrically connectable to a charging socket via a switch arrangement. The method includes: measuring a first electrical variable on the switch arrangement side facing the charging socket, by a first measuring device, measuring a second electrical variable on the switch arrangement side facing the vehicle battery, by a second measuring device, comparing the first and second electrical variables and closing the switch arrangement, if the first and second electrical variables substantially correspond, measuring the first and second electrical variables while the switch arrangement is closed, and adjusting the first measuring device and the second measuring device on the basis of a first measurement difference between measurement results of the first and second electrical variables while the switch arrangement is closed.
US10239408B2 Apparatus and method for controlling low voltage direct current converter for eco-friendly vehicle
An apparatus for controlling a low voltage direct current (DC)-DC converter (LDC) for an eco-friendly vehicle includes a reference current receiver for receiving a reference current, a ramp signal generator for generating a ramp signal by overlapping an input current of the LDC, and a DC offset and a sawtooth wave for adjusting a gradient of the ramp signal, and a comparator for generating a pulse width modulation (PWM) signal using the reference current received by the reference current receiver and the ramp signal generated by the ramp signal generator.
US10239407B2 Variable carrier switching frequency control of variable voltage converter
A controller is configured to select a rate of change direction of an output voltage of a variable voltage converter (VVC) based on a direction of current flow associated with a capacitor of the VVC, and to adjust a magnitude of the rate of change direction based on directions of current flow associated with the capacitor and an electric machine coupled to the VVC.
US10239406B2 Hybrid vehicle
During a predetermined drive in which the hybrid vehicle is driven with operation of the engine in such a state that the first inverter and the second inverter are shut down, the hybrid vehicle controls the engine and the step-up/down converter such that the hybrid vehicle is driven with output of a torque from a first motor to a driveshaft via a planetary gear by decreasing the voltage of the high voltage-side power line to be lower than a reverse voltage of the first motor in the range of not lower than a lower limit control voltage that is higher than an allowable lower limit voltage. The hybrid vehicle increases the lower limit control voltage during the predetermined drive, compared with the lower limit control voltage during a drive other than the predetermined drive.
US10239405B2 Fuel cell equipped vehicle system and control method for fuel cell equipped vehicle system
A fuel cell equipped vehicle system in which an external power supply is coupled to an electric power supply line, the electric power supply line being coupled to a fuel cell, an electric power being input/output to/from a vehicular battery through the electric power supply line, the fuel cell equipped vehicle system performing an insulation test of the electric power supply line before charging the vehicular battery, the fuel cell equipped vehicle system including an insulation test unit configured to perform the insulation test of the electric power supply line; a switch that couples and cuts off between the fuel cell and the electric power supply line; and a control unit configured to control a coupling and a cutoff to/from the electric power supply line of the vehicular battery and control the switch, wherein the control unit is configured to cut off the vehicular battery from the electric power supply line and control the switch to cut off the fuel cell from the electric power supply line, and then drive the insulation test unit.
US10239401B2 Electric motor and gearing assembly
An apparatus with an electric motor including a stator and a rotor; a shaft secured to the rotor; a gearing assembly coupled with the shaft; and a housing assembly defining a non-partitioned interior space housing both the electric motor and gearing assembly. The shaft may be unsupported by bearing assemblies and/or free of oil seals and similar sealing engagements between the electric machine and gearing assembly. The motor may be an axial flux motor having a single stator. The gearing assembly may be a planetary reduction gear assembly with a sun gear mounted on the shaft. The apparatus may include only a single electric motor or include a second electric motor and second gearing assembly. The embodiments having a single motor may be used to drive a fan or a vehicle wheel. The embodiments having two motors may be used as a differential drive.
US10239397B2 Sealing system for movable window of rear window assembly
A slider window assembly for a vehicle includes at least one fixed window panel and a movable window panel. A perimeter seal is disposed at a surface of the fixed window panel and includes a continuous sealing element that circumscribes an opening of the fixed window panel and that is configured to substantially seal against a surface of the movable window panel about a periphery of the movable window panel when the movable window panel is closed. The perimeter seal includes a sealing tab at a corner region of the perimeter seal where an upper sealing portion engages a first elongated side sealing portion. The sealing tab is joined with an elongated sealing lip of the upper sealing portion or the first elongated side sealing portion. The sealing tab extends from the elongated sealing lip toward the surface of the at least one fixed window panel.
US10239396B2 Multi-purpose vehicle
A multi-purpose vehicle having a fastback state and a wagon state, which comprises a vehicle body, a main liftback body and a first driving device. The vehicle body comprises a roof, a C-pillar and a tail. The main liftback body is movably connected with the roof and the tail. The first driving device is located in the vehicle body and is connected with the main liftback body, so as to drive the main liftback body to move relative to the C-pillar, therefore the multi-purpose vehicle can be converted between the fastback state and the wagon state.
US10239392B2 Arrangement of a cover of a folding-top compartment in a cabriolet
A cover (9) of a folding-top compartment in a cabriolet vehicle can be pivoted by way of links (10, 10) between a position in which the cover (9) covers the folding-top compartment and a position in which the cover (9) does not cover the folding-top compartment. The cover (9) has, at a distance from its pivoting connection, at least one first guide element (15), and on the body, there is provided at least one second guide element (18). During the transfer of the cover (9) into its closed position, the two guide elements (15, 18) interact, and guide the cover (9), as far as the closed position.
US10239390B1 Movable panel assemblies
A vehicle includes an opening, a first panel, and a second panel. The first panel and the second panel obstruct the opening in a closed position and are movable to an open position. In the open position, at least part of the first panel may be positioned forward of the opening, and at least part of the second panel may be positioned rearward of the opening. In the open position, at least part of the first panel may be pivoted upward relative to the opening, and at least part of the second panel may be positioned rearward of the opening. In the open position, at least part of the first panel may be positioned forward of the opening. In the open position, the first panel may be moved forward and downward into an interior space, and the second panel may be moved rearward and downward into the interior space.
US10239386B2 Laminated glazing comprising profiled clip in beading
A glazing and notably a vehicle glazing, includes a laminated glazed element including an outside sheet of glass, an inside sheet of glass and an interlayer sheet of plastic situated between the two sheets of glass, wherein the profiled beading includes, when viewed in cross section, an interlayer flange situated between the interlayer face of the outside sheet of glass and the interlayer face of the inside sheet of glass.
US10239384B2 Air outlet device for feeding air to a vehicle interior in an controlled manner
An air outlet device for feeding air to a vehicle interior of a motor vehicle in a controlled manner includes an air flow duct and an air outlet opening element with an air outlet opening. The air flow duct is connected to the air outlet opening element and is adapted to conduct air from an interior ventilation device into the vehicle interior via the air outlet opening. The air flow duct has a first duct segment and a second duct segment, which is arranged between the first duct segment and the air outlet opening element. The first duct segment can be displaced in direction transverse to the longitudinal axis of the first duct segment. The first duct segment is designed to control a direction of the air flowing out of the air outlet opening in accordance with the displacement of the first duct segment. At least one fin-like, movable air-conducting element is arranged in the first duct segment, can be displaced together with the first duct segment, and is adapted to control a direction of the air flowing in the first duct segment and thus a direction of the air flowing out of the air outlet opening in accordance with the position of the air-conducting element.
US10239379B2 Method for determining an actual level of a vehicle
A method for determining an actual level of a vehicle, includes determining an actual level of the vehicle as a function of a distance between at least one wheel of the vehicle and a superstructure of the vehicle, wherein the distance is determined by means of a signal detected by at least one chassis sensor, wherein the signal includes at least signal portions that correspond to an own movement of the vehicle and signal portions that correspond to an excitation by a road on which the vehicle actually drives; filtering the signal portions corresponding to the own movement of the vehicle out of the signal detected by the at least one chassis sensor by means of a filter function; calculating the actual level of the vehicle from a difference between the filtered signal without the signal portions that correspond to the own movement of the vehicle and the signal detected by the at least one chassis sensor.
US10239378B2 Robot and method for traversing vertical obstacles
A robot has a robot body on a frame structure, the robot body having at least one enclosed space to hold at least one delivery item. At least one sensing device detects objects along a direction of motion of said robot. The robot has six wheels, where at least two wheels on a side of the frame are connected to each other. The axis of rotation of each wheel is substantially fixed with respect to the robot during forward, rearward, and turning motion of the robot. During transition, via a substantially vertical obstacle, from a first substantially horizontally surface to a second substantially horizontally surface higher than the first substantially horizontally surface, one of the connected wheels causes an upward or a downward force to be applied to the other connected wheel.
US10239377B2 Vehicle with three or more wheels provided with an anti-roll stabiliser device and anti-roll control method of a vehicle having at least three wheels
A vehicle with 3 or more wheels includes at least two wheels aligned on the same axis. The vehicle has an intermediate centerline plane between the wheels parallel to a direction of movement, including a mass suspended in relation to the wheels defining a passenger or containment compartment, and two suspension groups kinematically connecting the suspended mass to the two aligned wheels. An anti-roll stabilizer device has at least one compensation mass kinematically connected to the suspended mass via a guide and movable in relation thereto. The anti-roll stabilizer device has a drive of the compensation mass to distance or bring the compensation mass closer to the centerline plane on the side opposite the displacement of a barycenter of the suspended mass with respect to the same centerline plane, to oppose the displacement with respect to the centerline plane of the position of the barycenter of the suspended mass.
US10239376B2 Hydraulic damper with an x-flow piston assembly
A hydraulic damper including a piston assembly having a piston body including at least two first channels and at least two second channels. The first and second channels are sloped. A compression side of each of the first channels is positioned radially outward relative to a rebound side. A rebound side of each of the second channels is positioned radially outward relative to a compression side. At least one main disc at least partially covers the rebound side of each of the first channels, and at least one main disc at least partially covers the compression side of each of the second channels. At least one supplementary channel is positioned radially inward with respect to the first and second channels. At least one supplementary disc at least partially covers at least one of a rebound side and a compression side of the at least one supplementary channel.
US10239372B2 Equalizer for suspension system
An equalizer includes a pivot arm pivotally connected between first and second spaced-apart plates fixedly connected to each other. First and second bump stops extend from one of the first and second plates to or toward the other of the first and second plates. A first shock absorber is disposed and selectively compressible between the pivot arm and the first bump stop. A second shock absorber is disposed and selectively compressible between the pivot arm and the second bump stop.
US10239370B2 Wheel suspension system
Robotic devices are presented including: a body; an electronic computing device housed within the body; and at least two wheeled suspension systems coupled with the body, each wheeled suspension system including, a first suspension system including: a frame, a rotating arm pivotally coupled to the frame on a first end and coupled to a wheel on a second end, and an extension spring coupled with the rotating arm on a third end and the frame on a fourth end, where the extension spring is extended when the wheel is retracted, a second suspension system including: a base slidingly coupled with the frame, and a number of vertically positioned extension springs coupled with the frame on a fifth end and the base on a sixth end.
US10239366B2 Wheel position detecting device and tire air pressure detecting apparatus having the same
A wheel position detecting device can suppress an erroneous detection of a wheel position even if a moving direction of a vehicle cannot be determined by wheel speed sensors whether in a forward direction or in a rearward direction. When an edge number (or a tooth number) is incremented based on detection signals of the wheel speed sensors of one, two or three wheels while the vehicle is at a halt, the edge number (or the tooth number) is not used as learning data. Thus, it is less likely that the wheel position is erroneously detected based on erroneous learning data. Therefore, even if the moving direction of the vehicle cannot be determined whether in the forward direction or the rearward direction by the wheel speed sensors, the wheel position detecting device can suppress the erroneous wheel position detection.
US10239356B2 Pneumatic tire
A pneumatic tire is provided with improved braking performance and turning performance on ice. Circumferential narrow grooves are disposed at a density in the tire width direction of not less than 0.06 grooves/mm and not more than 0.2 grooves/mm. Width direction narrow grooves extend at an angle with respect to the tire width direction of not less than −45° and not more than +45°. The circumferential narrow grooves have at least one bent portion. The bend angle of the bent portion is not less than 40° and not more than 160°.
US10239349B2 Foldable chair having leg strengthening means
A foldable chair includes a chair body having two front legs, two rear legs connected pivotally to the two front legs; a seat disposed on the chair body; a backrest disposed on the chair body so as to be located above the seat; four leg support elements attached respectively to bottom ends of the two front legs and the two rear legs; four casters attached respectively to bottom sides of the leg support elements; two reinforcing plates attached respectively to inner sides of the two front legs and spaced at a predetermined distance from the leg support elements; and two strengthening rigs attached respectively to the two front legs and extending into the front and rear legs to an extent beyond bottom ends so as to be located between the reinforcing plates and the leg support elements, thereby strengthening the front and rear legs.
US10239347B2 Magnetic omni-wheel with roller bracket
A multidirectional wheel for traversing a surface is provided that includes a magnet and a plurality of rollers disposed around an outer periphery of each of the hubs of the wheels. The rollers are mounted for rotation in a second axial direction that is perpendicular to a first axial direction of the wheel. The rollers are supported by a plurality of magnetically-inducible brackets attached to the hub. The brackets are optimally sized and shaped to reduce the space between the magnetized materials of the wheel and the surface upon which the wheel travels.
US10239341B2 Picture album
A picture album can include a picture frame and has a front cover panel, back cover panel, and four side panels, all in a rectangular shape and covered by a material. The edges of the sides and the front cover have embedded magnets that allow the album to open flat and recover its original shape through engaging magnetic force when closed.Multiple picture sheets can be stored in the album using a multi-ring binder spine hardware. A display window is located on the front cover panel where a picture insertion sheet can be attached to the back of the display window by magnetic force so that a picture located in the picture insertion sheet can be viewed through the display window located on the front cover panel.
US10239338B2 Decorating material irradiated electron beam resin laminated on substrate
There is provided a decorative material which hardly undergoes deterioration of a substrate even when irradiated with an electron beam, and is excellent in surface properties such as stain resistance, abrasion resistance and marring resistance. The decorative material of the present invention comprises a substrate, and a pattern layer and/or a colored layer, and a surface protective layer which are successively laminated on the substrate, wherein the surface protective layer is obtained by crosslinking and curing an electron beam-curable resin composition, and a rate of reduction in a folding endurance of a material obtained by applying the electron beam-curable resin composition onto the substrate and then irradiating an electron beam to the electron beam-curable resin composition, relative to a folding endurance of the substrate before applying the electron beam-curable resin composition thereonto is 70% or lower as measured in the CD direction (lateral direction) of the substrate.
US10239337B2 Printable recording media
Disclosed herein is a printable recording media including a substrate and, at least, an ink receiving layer that includes a first distinct layer and a second distinct layer that is applied on top of the first distinct layer. The first distinct layer includes an electrical charged substance and the second distinct layer includes, at least, a polymeric binder and nano-size inorganic pigment particles. Also disclosed herein is a method for making the printable recording media.
US10239335B2 Printing apparatus
A printing apparatus performs printing on a sheet including adhesive label paper and includes a thermal head configured to perform printing on the sheet using heat, a platen roller which is positioned to face the thermal head, and configured to rotate to transport the sheet when the sheet is interposed between the thermal head and the platen roller, a heating unit configured to heat the thermal head, an output device, and a controller. The controller is configured to operate in a cleaning mode, in which the controller causes the thermal head to be heated to a predetermined temperature at which glue of the label paper is softened while the platen roller is in contact with the thermal head and rotating without transporting any sheet, and controls the output device to indicate that the thermal head has been heated up to the predetermined temperature and is ready for cleaning.
US10239333B2 Cutter, printer, and method of controlling cutter
A cutter includes a fixed blade, a movable blade, a drive motor that moves the movable blade, and a controller that drives the drive motor to move the movable blade toward the fixed blade and to cut a medium. The controller drives the drive motor such that output torque of the drive motor during a process other than a cutting process where the medium is cut becomes lower than the output torque of the drive motor during the cutting process.
US10239327B2 Method of printing and printer
A method of printing a pattern from at least two rows of fluid ejection nozzles, said nozzles ejecting a first fluid in a multi-pass printing mode, the method comprising: dividing the pattern to be printed between the rows of fluid ejection nozzles; applying masks to the rows of fluid ejection nozzles for printing with selected nozzles of each of the rows of fluid ejection nozzles during each pass; wherein a first mask for printing from a first row of fluid ejection nozzles during an n-th pass is different from a second mask for printing from a second row of fluid ejection nozzles during said n-th pass.
US10239324B2 Liquid-consuming apparatus
A liquid-consuming apparatus includes: a tank including a liquid storage chamber which stores a liquid, an inlet formed in a surface of the tank, and an outlet through which the liquid from the liquid storage chamber flows; a cap which is movable between a first position and a second position; a cover which is movable relative to the tank between a closed position and an open position; and a holding member which is connected to the cap and which holds the cap at the second position. The cap at the second position or the holding member is configured to obstruct a movement of the cover from the open position to the closed position.
US10239323B2 Bottle set
It is difficult to reduce the number of parts of a known bottle set. A bottle set includes: a bottle having an ink container capable of containing ink, and a nozzle through which the ink in the ink container can flow out; and a lid member that is attachable to and detachable from the bottle, and can cover the nozzle in a state where the lid member is attached to the bottle. An outflow port from which the ink in the ink container can flow out is formed in the nozzle, the lid member has a sealing portion that seals the outflow port in a state where the lid member is attached to the bottle, and the sealing portion is integrally formed in the lid member.
US10239322B2 Liquid cartridge
A liquid cartridge includes a first surface, a second surface spaced apart from the first surface, and a third surface extending between the first surface and the second surface, with a liquid outlet through the first surface. A circuit board is mounted on the third surface. A locking mechanism includes a locking surface that extends above the third surface, and a liquid detection mechanism includes a light access portion. The light access portion is disposed between the circuit board and the locking surface, and the circuit board is disposed between the first surface and the light access portion.
US10239320B2 Inkjet recording apparatus capable of smoothly supplying ink to first damper chamber and second damper chamber
An inkjet recording apparatus includes: a first tank; a second tank; a recording portion including a first damper chamber and a second damper chamber; a first switch; a pump; a second switch; and a controller. The first switch is configured to be switched between a first state and a second state. The second switch is configured to be switched between a third state and a fourth state. After attachment of first and second cartridges to the inkjet recording apparatus, the controller performs an initial ink introduction including one of: a first drive process to drive the pump in a state where the first switch is in the first state and the second switch is in the fourth state; and a second drive process to drive the pump in a state where the first switch is in the second state and the second switch is in the third state.
US10239318B2 Liquid discharge apparatus and maintenance method for the liquid discharge apparatus
A liquid discharge apparatus includes a plurality of pressure chambers that generate a pressure for discharging a liquid, a plurality of nozzles that communicate individually with the pressure chambers and that discharge the liquid, a common liquid chamber that includes a plurality of supply openings and that has, at an end portion side in an arrangement direction of the supply openings, a region in which flow speed of the liquid flowing toward the supply openings is higher than in another region, and a controller that controls a maintenance by expelling the liquid from the nozzles. During the maintenance, the controller controls expelling the liquid from a first nozzle to a second nozzle that is one of nozzles located on the end portion side of the first nozzle in the arrangement direction of the supply openings, in an order of the first nozzle to the second nozzle.
US10239316B2 Printhead having heated shield plate
An inkjet printhead includes: a manifold having a plurality of ink outlets defined in a manifold surface; a plurality of printhead chips mounted to the manifold surface and aligned with the ink outlets; a PCB mounted to the manifold surface and offset from the ink outlets, the PCB being electrically connected to the printhead chips; and a shield plate covering the PCB. The shield plate has one face in thermal contact with the PCB and an exposed opposite face defining a lower surface of the printhead.
US10239310B2 Non-transitory computer readable medium stored with predicted value output program, predicted value output device, and predicted value output method
A non-transitory computer readable medium stored with a predicted value output program, a predicted value output device, and a predicted value output method that can improve an accuracy of a predicted value of a value related to printing by an ink jet printer are provided. A printer controller configured to acquire and output a predicted value of a print-related value as a value related to printing by a 3D printer from 3D model data used in the printing by the 3D printer according to a print-related value prediction rule acquires an actual value of the print-related value in the printing by the 3D printer using the 3D model data (S231), and corrects the print-related value prediction rule based on a corresponding relationship of the 3D model data and the actual value acquired in S231 (S232).
US10239307B2 Printing system for printing on a substantially planar surface of a 3D-object and a method for printing thereof
A printing system for printing on a substantially planar surface of a 3D-object includes a printer for printing on the planar surface of the 3D-object and a controller configured to control printing of the printer. The printing system further includes a mask generation module configured to generate a mask having the shape of the planar surface from a 3D-model of the 3D-object and to provide the controller with the mask to prevent printing outside the planar surface according to the mask.
US10239303B2 Equipment and method for automatic plasticizing
An automatic plasticizing equipment (17) for image sheets (26) comprises a first plasticizing device (27) and an electronic control unit (22) for the plasticizing device and in which the first plasticizing device employs a first plasticizer film (28) unwinding from a first film spool (29). The plasticizing equipment (17) processes image sheets (26) with associated enhanced sheet codes (ESC), readable by machine, having dimension and finishing information associated to said image sheets (26). The equipment (17) further comprises a second plasticizing device (41), downstream of the first plasticizing device (27) for a second plasticizer film (42) of different typologies unwinding from a second film spool (43) for pre-forming plasticized image sheets (31, 44) of different typologies; and the electronic control unit (22) responds to the dimension and finishing information from the enhanced sheet codes (ESC) for selectively activating the first plasticizing device (27) or the second plasticizing device (41) or to leave the plasticizing devices deactivated so as to obtain plasticized image sheets (31, 44) of different typologies of plasticization or non-plasticized image sheets (46).
US10239299B2 Laminating apparatus
A laminating apparatus includes workpiece transport units, a vacuum laminating device and a flat press device. The flat press device includes a ball screw having a screw shaft and supporting a first one of a pair of pressing elements, a servomotor connected to the screw shaft of the ball screw, a gap measuring device (linear scale) for measuring a distance between the first pressing element and the second pressing element, and a pressing gap control system for moving the first pressing element to a position in which a predetermined gap is defined between the first pressing element and the second pressing element to stop the first pressing element at that position. The pressing gap control system changes the RPM of the servomotor, based on information on the distance between the first and second pressing elements which is provided from the gap measuring device.
US10239297B2 Scratch-resistant polycarbonate resin laminate
The present invention aims to provide a multi-layer sheet and a multi-layer film, each ensuring not only high transparency but also scratch resistance and being easy to print and thermoform.The above aim was achieved by a multi-layer sheet and a multi-layer film, each being a laminate which comprises a polycarbonate-based resin layer as a substrate and has a thermoplastic acrylic resin layer containing silicon dioxide particles as an outermost layer on one or both surfaces of the substrate, wherein the silicon dioxide particles have an average particle size of 0.1 to 2 μm, and wherein the content of the silicon dioxide particles is 0.1% to 1% by weight, relative to the total weight of the thermoplastic acrylic resin layer.
US10239290B2 Laminated body, molded body, molded product, and method for manufacturing molded product
A resin sheet is manufactured by: forming a rapidly-cooled transparent polypropylene sheet by rapidly cooling a molten polypropylene resin; laminating on the rapidly-cooled transparent polypropylene sheet a resin layer of polyurethane resin, the polyurethane resin having a tensile-rupture elongation in a range from 150% to 900% and a softening point in a range from 50 degrees C. to 180 degrees C.; and laminating a print layer on the resin layer. A molded article having a non-planar molding made of the resin sheet is provided by insert molding. The molding is formed into a complicated shape where a part of the molding has: 150% or more of an elongation ratio; 0.8 or less of a film-thickness ratio (B/A) before and after the sheet is molded; and/or a surface area ratio (Y/X) before and after the sheet is molded in a range from 1.5 to 5.
US10239288B2 Glass pane construction
The present invention relates to a glass pane construction, particularly bullet proof glass pane, to be used in a motor vehicle, having several transparent panes and layers made of glass, ceramic or synthetic material, which are connected in a layered manner connected to each other in a laminate, electrical controllable or switchable electrochromic layer means for electrical controlling or switching of the light transparency of the glass pane construction or of the bullet proof pane, wherein a laminar transparent UV filtering layer means for filtering of striking ultraviolet (UV) radiation is provided so that none or only a part of the UV radiation passes to the electrochromic layer means.
US10239275B2 Corrugated fiberboard printing device and box-making machine having the same
A corrugated fiberboard printing device includes a protection device which regulates approaching of a corrugated fiberboard within a predetermined distance against an inkjet head, and a controller. The protection device includes multiple regulation devices which are juxtaposed in a width direction of the corrugated fiberboard, and a movement mechanism which moves each of the multiple regulation devices in the width direction. The controller includes a specific column setting unit which is set to classify a specific column, in which a printing quality is less influenced even when the specific column is regulated by the regulation device, with respect to the corrugated fiberboard in a sheet width direction based on order information, and a movement mechanism control unit which controls the operation of the movement mechanism and moves each of the regulation devices so as to regulate the corrugated fiberboard in the specific column.
US10239274B2 Intersecting die lifting system
A pneumatic die transfer system for a press machine comprises at least two primary roller rails and at least two secondary roller rails set in respective T-slots in a bolster. The primary roller rails are perpendicular to the secondary roller rails. Airbags below each roller rail are selectively inflated to elevate either the primary or the secondary roller rails above the bolster face. The secondary roller rails each have a plurality of discontinuities configured to receive the primary roller rails and their associated airbags in an intersecting fashion. As a result, the bolster can be easily fabricated with intersecting T-slots and relatively few roller rails are needed to achieve fully orthogonal conveyance of a heavy die over the face of a bolster.
US10239273B2 Thermal insulation layer and pressure transfer medium for high-pressure high-temperature cell
HPHT press system includes a thermal insulation layer. The thermal insulation layer includes CsCl, CsBr, CsI, or a combination thereof, and the thermal insulation layer is electrically insulating. The thermal insulation layer may include a thermal insulation sleeve and/or a thermal insulation button for an HPHT cell.
US10239272B2 Methods of tire retreading with abutting tread components
The present invention includes methods for forming a retreaded tire, which includes the steps of providing an annular tire carcass and providing a plurality of tread components each comprising an independent structure, which are then assembled to form an assembled tire tread. The tread is subsequently bonded to the tire carcass to form a retreaded tire, the tire tread being arranged along an outer circumference of the annular tire carcass with a bonding layer between the tire tread and the tire carcass, the bonding layer comprising an uncured elastomeric material being cured during the step of bonding. The tire tread is assembled such that the plurality of tread components are concurrently arranged around the outer circumference of the tire carcass to form a tire tread.
US10239271B2 Strip, method for manufacturing the same, and method for manufacturing pneumatic tire
A strip of a thermoplastic elastomer to be wound spirally on a cylindrical drum for forming an inner liner for a tire having a shape close to a finished sectional shape is provided. The strip is formed of composite layers of (A) a first layer made of a styrene-isobutylene-styrene triblock copolymer and (B) a second layer containing at least one of a styrene-isoprene-styrene triblock copolymer and a styrene-isobutylene diblock copolymer. The strip further has a strip main body and ear portions arranged on opposite sides thereof. The strip main body has a thickness (T1) of 0.05 mm to 1.0 mm. The ear portions have a thickness (T2) thinner than the thickness (T1) of the strip main body and a width (W2) of 0.5 mm to 5.0 mm. This ribbon-shaped strip reduces unevenness of the surface of a sheet formed by the opposite ends of the strip when manufacturing an inner liner.
US10239269B2 Rigid core and method for manufacturing pneumatic tire using same
According to the present invention, the cycle time is reduced for a core removal step while suppressing displacement of the affixing position for the rubber member during a green-tire forming step. This rigid core has a ring-shaped core body having a tire forming surface for molding the inner surface of a pneumatic tire. The core body is formed from a plurality of core segments that are split in the circumferential direction and movable in the tire radius direction. The surface roughness (Ra) of the outer surface of the core segments forming the tire forming surface is 2.0-20.0 μm.
US10239265B2 Structural composite preform wet-out and curing system and method
In accordance with one embodiment of the present invention, the invention comprises a continuous structural composite preform wet out system and method which takes as an input pre-formed structural composite structures with a structural foam core, passes these structures through a wetting system which may comprise sprayers, brushes, a die or dies, or other wetting means; applies a cure process such as ultraviolet light, heat, curing agent or other cure method, and produces a completed, cured structural composite structure such as a beam or panel for use in any structure as desired by the user. The improved structural composite wet out system of the invention provides run rate, ease of use, structure efficiency and handling advantages over the pultrusion systems of the prior art by achieving higher production rates, the ability to use light cure resins and the ability to produce composite structures of non-uniform cross-section.
US10239262B2 Fiber scaffolds for use in tracheal prostheses
A synthetic organ suitable for transplantation into a biological organism is provided. This synthetic organ includes a three-dimensional polymer scaffold, wherein the shape and dimensions of the polymer scaffold are based on a native organ, wherein the polymer scaffold further includes at least one layer of polymer fibers that have been deposited by electrospinning, and wherein the orientation of the fibers in the scaffold relative to one another is generally parallel, random, or both; and wherein the polymer scaffold has been preseeded with at least one type of biological cell prior to implantation into a biological organism, and wherein the at least one type of biological cell is operative to facilitate integration of the polymer scaffold into the organism so that the polymer scaffold may function in a manner significantly similar to or the same as the native organ.
US10239261B2 High frequency oscillator, high frequency welding system and method for controlling the frequency using said type of high frequency oscillator
A high-frequency oscillator includes an electric resonant circuit, and a high-frequency welding system and a method for controlling the frequency uses a high-frequency oscillator, in particular in a high-frequency welding system. The electric resonant circuit includes at least one electronic component having an inductance and at least one capacitor having a capacitance. At least one additional magnetic coil is associated with the electronic component and can electronically influence the inductance of the electronic component.
US10239253B2 Method for embossing of substrates
A method for embossing a structure material on a substrate disposed within a device having side walls, a base plate and a cover that define a working space that is isolated from a surrounding environment. The method includes the steps of: a) moving the substrate using a first calibration means and aligning the substrate with an application means, b) applying the structure material to the substrate, c) moving the substrate using a second calibration means that is located at least partially in the working space wherein the substrate is disposed within the working space and is aligned with an embossing means that is located at least partially in the working space, and d) embossing the structure material on the substrate while the substrate is in the working space using the embossing means, wherein the working space has a defined atmosphere, before and during the step of embossing, without interruption.
US10239252B2 Tank production system and method
A tank production system and method that can suppress peeling of normally wound fibers when fibers not wound at predetermined position are peeled off. The system includes a rotation unit that rotates a liner, a storage unit that has recorded thereon the number of revolutions of the liner, and a detection unit that detects abnormality in the position of the fibers wound on the outer periphery of the liner. The rotation unit, when abnormality in the position of the fibers is detected by the detection unit, refers to the number of revolutions of the liner recorded on the storage unit and rotates the liner in an opposite direction to the direction in which the fibers are wound, back to the number of revolutions of the liner at a point when the winding of fibers to form a fiber layer, which includes the fibers detected at the abnormal position, has started.
US10239250B2 Blow moulded container and manufacture thereof
A method of forming a blow molded container in the form of a tub, the method comprising the steps of: providing an injection molded preform composed of a biaxially-orientable thermoplastic material, the preform being substantially planar; heating the preform; and stretch blow molding the heated preform within a mold cavity to form a tub having a bottom wall and an annular sidewall having an upper edge, the tub comprising biaxially oriented thermoplastic material in the annular sidewall and at least an outer portion of the bottom wall, the stretch blow molding step using at least one stretch rod to engage an inner side of the preform and axially to stretch at least a part of the preform prior to blowing a pressurized gas against the inner side which urges the opposite side of the preform radially outwardly against the mold.
US10239249B2 Extruder including an improved homogenising member and method for extruding a viscous material
An Extruder for shaping a viscous material such as a blend of rubber is disclosed herein. The extruder includes a screw rotationally driven about an axis (XX′) in a barrel and bearing one or more helical flights extending radially outwards from a central shaft of the screw, the extruder comprising a material homogenization zone (H) through which a screw portion comprising interrupted flight elements forming empty annular spaces extends axially, and a barrel portion delimiting the said homogenization zone bearing flight elements extending radially inwards into the said empty annular spaces. According to the disclosure, the barrel portion delimiting the homogenization zone is itself rotationally driven about the axis XX′ to form a rotary barrel.
US10239248B2 Fabric and die design for divided conduit
A method of forming a conduit having at least one strip-shaped fabric substrate dividing the conduit into channels. The method contains obtaining an extrusion die configured to form the wall of the conduit and a slot configured for receipt of a strip-shaped fabric substrate and introducing a strip-shaped fabric substrate into the slot. The strip-shaped textile is air permeable and contains enlarged regions at the first and second longitudinal edges. Molten polymer is introduced at a first point in the extrusion die and at the first point the slot and the area configured to form the wall of the conduit are not in communication. The slot is exposed to the molten polymer at a point between the first point and the die exit forming the first polymeric layer of the conduit such that the first longitudinal and second longitudinal edges of the strip-shaped fabric substrate embed into the molten polymer.
US10239243B2 Microbubble creating method using a forming machine
A microbubble creating method using a forming machine for creating microbubbles by: installed a microbubble generating member in a mold, feed screw or barrel for enabling a perforated tip of the microbubble generating member to be surrounded by the applied fluid polymer so that when a high pressure high temperature gas is delivered through the perforated tip of the microbubble generating member, microbubbles are created with well mixed with the fluid polymer, and the expected foamed polymer product is thus obtained after cooling.
US10239236B2 Microneedle device and method of preparation
Microneedle devices have projections that are generally sharp and elongated and designed to disrupt the upper layer of the skin, cause micro-indentations, or pierce the skin. High density arrays are produced using micro-fabrication or micro-molding techniques. The assembly of individual needles does not lend itself to the production of high density arrays. A method of forming microneedle arrays is disclosed which comprises attaching a plurality of microneedles to a substrate, and building up a 2-dimensional microneedle array by wrapping layers of the substrate around a core or folding the layers repeatedly back upon themselves. The arrays are capable of needle densities with a pitch within the range of needle radius plus several micrometers to millimeters.
US10239234B2 Moldable uncured nonwoven composite and molded cured composite
A process for forming a moldable, uncured nonwoven composite containing forming a structural nonwoven layer, at least partially impregnating the structural nonwoven layer with an uncured, water-based thermosetting resin having a cure temperature of at least about 160° C., and at least partially drying the uncured, wet nonwoven composite such that the temperature at the inner plane is less than about 130° C. forming an moldable, uncured composite. The structural nonwoven layer contains a plurality of bi-component binder fibers and a plurality of reinforcing fibers, the bi-component fibers containing a core and a sheath. The core contains a polymer having a melting temperature of at least about 180° C. and the sheath contains a polymer having a melting temperature less than about 180 ° C. A process for forming a molded, cured composite containing forming a structural nonwoven layer and a molded cured nonwoven composite are also disclosed.
US10239233B2 Element for a co-rotating twin screw processor
An element for a co-rotating twin screw processor, the element having a lead ‘L’ and at least one continuous flight helically formed thereon and, wherein the flight transforms at least once from a first non-integer lobe flight into a second non-integer lobe flight in a fraction of the lead ‘L’ and transforms back to the first non-integer lobe flight in a fraction of the lead ‘L’.
US10239232B2 Bolster
The present invention provides a long-bladed bolster 1, comprising a substantially planar cutting body 2 having one edge formed as a blade 3 of sufficient length so that the blade 3 is arranged in use to be positioned substantially centrally on a concrete masonry unit (CMU) to enable the block to be divided without the bolster 1 requiring repositioning, the bolster having a striking body on a second long edge of the cutting body opposite to the cutting blade configured to receive repeated blows from a striking implement in use and to transmit these through the cutting body to the blade and the bolster having an integral handle that extends from the cutting body and/or striking body of the bolster substantially centrally along the length of the cutting body 2 and substantially orthogonally to the plane thereof.
US10239230B2 Slurry distributor, system and method for using same
A slurry distribution system can include a feed conduit and a distribution conduit in fluid communication therewith. The feed conduit can include a first feed inlet and a second feed inlet disposed in spaced relationship thereto. The distribution conduit can extend generally along a longitudinal axis and include an entry portion and a distribution outlet in fluid communication therewith. The entry portion is in fluid communication with the first and second feed inlets of the feed conduit. The distribution outlet extends a predetermined distance along a transverse axis, which is substantially perpendicular to the longitudinal axis. The slurry distribution system can be placed in fluid communication with a gypsum slurry mixer adapted to agitate water and calcined gypsum to form an aqueous calcined gypsum slurry.
US10239222B2 Insert and pin for pin ejector system for a rotary cutting die arrangement and associated methods
An insert assembly is received in a recess on the outer surface of a rotary cutting cylinder. The insert has a hole for a slug ejector pin which is slidingly engagable with the insert. The hole is arranged on the insert to communicate with a through hole in the recess that extends into the interior of the cylinder. When the slug ejector pin is inserted in the pin hole, the pin proximal end is received in the recess hole adjacent to the compressible core and the pin distal end projects from an outer surface of the insert. When the pin is assembled with the insert and the insert is assembled with the cylinder, the pin proximal end operatively engages the compressible core when the pin retracts into the pin hole of the insert and the pin proximal end operatively engages the insert when the pin projects from the pin hole.
US10239221B2 Cutting device
The invention concerns a cutting device (1) for reducing the width of a ready-made roller blind blank (28) comprising a roller tube onto which a fabric has been wound. The cutting device (1) comprises a mandrel (13), which is adapted to be inserted into and hold an end to be cut of the roller tube, and a knife arrangement, which is adapted to circumferentially cut first the fabric wound on the roller tube and then the roller tube on the mandrel (13) such that the width of the ready-made roller blind blank (28) is reduced. The invention also concerns a ready-made roller blind blank (28), which comprises a roller tube, onto which a fabric has been wound and which is adapted to be cut by means of a cutting device (1) according to the invention. For this the roller blind blank (28) comprises a disposable wrapping, which bears a visible measurement scale along at least one end portion of the roller blind blank (28).
US10239220B2 Laser device battery powered, which shows the cutting path to get equal portions of a cake, pizza or similar food
This invention has the aim to assist the cutting of a cake, pizza or other similar foods through a battery-powered laser device, which shows the cutting path to get equal portions of a cake, pizza or similar foods; the laser light beam displays a cutting line through which a knife, or other tool pass to cut a equal number of portions according to a user's need.
US10239218B1 Structural frame for covered and animated segments of a robotic figure
A robot with an animated segment including a generally cylindrical structural frame. The frame includes a plurality of spaced apart plastic ribs that each have a curved or arcuate body that is arranged to be convex relative to a central axis of the structural frame. A first end of each rib is pivotally coupled with a lower ring, and a second end of each rib is pivotally coupled with an upper ring. A flexible outer covering is positioned over the structural frame and is attached to one or more of the ribs. This provides a robotic segment that is animated with an organic feel and natural movement by providing an actuator in the robot segment that is operated by a controller to move one or both of the rings such as linearly along a central axis of the structural frame (e.g., toward and away from the other ring).
US10239213B1 Flexure assembly for force/torque sensing
An example device includes a first flexural element, a second flexural element, a first rigid component and a second rigid component. The rigid components have a fixed height that axially offsets the first flexural element from the second flexural element. The first rigid component is coupled to the first flexural element at one or more connection points on a first plane and coupled to the second flexural element at one or more connection points on a second plane. The second rigid component is coupled to the first flexural element at one or more other connection points on the first plane and coupled to the second flexural element at one or more other connection points on the second plane.
US10239193B2 Handheld tool apparatus
A handheld tool apparatus comprising a spindle blocking apparatus and a torque limiting unit that includes at least one limiting spring and a stop arrangement that is supported movably against the limiting spring. It is provided that the stop arrangement of the torque limiting unit nonrotatably secure a wedging arrangement of the spindle blocking apparatus.
US10239192B2 Key device for holding a nut retainer
The invention concerns a key device intended to hold a nut retainer in the radial position, when tightening the nut on an associated screw connection, characterized in that it comprises a handle (54) and a head (52) comprising a housing (56) into which a tab of the nut retainer is inserted, said tab being intended to be folded 90° on a body carrying the screw connection, after tightening of the nut, one face (58) of the head having geometry that matches a portion of the body carrying the screw connection that receives the nut, such that the end of the nut retainer, inserted into the head of the key, is held exactly perpendicular to the outer surface of said portion of the body when the nut is tightened.
US10239191B2 Dual fastener manipulation device
A dual fastener manipulation device may be used to manipulate two fasteners, having the same rotational axis, which may be separated by various distances and various sized objects. The dual fastener manipulation device may include a first wrench having a first fastener engaging head, a first handle, and a pivot stud. A second wrench element may have a second fastener engaging head and a second handle. A pivot linkage may be pivotally coupled to the pivot stud, and a floating stud may be coupled to both the second wrench and to the pivot linkage. The first and second fastener engaging heads may be engaged to two fasteners having the same rotational axis, while the pivot linkage and floating stud may maintain the rotational axis of the fastener engaging heads, while also allowing the fastener engaging heads to be moved closer to or farther from each other.
US10239189B2 Clamping system for seven-fold cutting
The invention relates to a clamp for seven longitudinal profiles (1, 2, 3, 4, 5, 6, 7) arranged next to one another and oriented in a longitudinal direction (L), said clamp having one clamping jaw (11) and another clamping jaw (12) which are movable towards one another and away from one another, with a receiving area (13) in the one clamping jaw (11), which receiving area has a bearing face (13c) at the bottom for two of the seven longitudinal profiles (2, 3), said bearing face being movable at least in some regions relative to the clamping jaw (11) transversely to the longitudinal direction (L), and with another receiving area (14) provided in the other clamping jaw (12) for the bearing of four others of the seven longitudinal profiles (1, 4, 5, 6).
US10239188B2 Method of cleaning and sanitizing medical instruments and accessories and apparatus therefor
A method of cleaning and sanitizing surgical tools or surgical instruments and accessories in general, and a device configured to implement the method. The method includes the use of a an abrasive cleaning material, which is emitted under pressure and at high speed to abrade and remove substances that adhere to the surfaces of the instruments and accessories, and the pressure of which can be regulated according to the type of surface to be cleaned.
US10239187B2 Methods for post-mold processing a Venturi device or check valve
Methods for post-mold processing a Venturi device for generating vacuum are disclosed that improve the evacuation time thereof. The methods include providing a molded Venturi device having a body defining a Venturi gap between an outlet end of a converging motive passageway and an inlet end of a diverging discharge passageway, where the outlet end defines a motive exit having flash extending radially inward and the inlet end defines a discharge inlet having flash extending radially inward. Then, the method includes positioning the molded Venturi device with an inlet end of the converging motive passageway facing a blasting nozzle or with an outlet end of a diverging discharge passageway facing a blasting nozzle, and propelling blasting media into the motive inlet or the discharge exit of the Venturi device to remove the flash in the motive exit and in the discharge inlet, or vice versa.
US10239178B2 Laser projector with dynamically adaptable focus
A laser projector assembly for projecting a template onto an object is provided. The laser projector assembly includes a frame, a laser source for generating a laser beam being affixed to said frame, a sensor assembly, a lens assembly and a galvanometer assembly. The sensor assembly is affixed to said frame for identifying surface locations of three dimensional objects. The lens assembly includes a tunable lens for changing a focus of the laser beam received from said laser source. The galvanometer assembly redirects the laser beam received from said lens assembly along a scanning path. The lens is disposed in a fixed location relative to said sensor assembly and is tunable in response to the surface locations of the three dimensional objects identified along the scanning path of the laser beam by said sensor assembly.
US10239177B2 Metrological apparatus and method for adjusting the attitude of a rotation-symmetrical workpiece
A metrological apparatus (15) is disposed for adjustment of an attitude of a workpiece (16) having an arcuate upper surface (17) relative to a rotary axis (C) of the metrological apparatus (15). The workpiece (16) is brought into a first rotary position (c1). A plurality of measured points within a measuring plane on the upper surface (17) is recorded. The workpiece (16) is moved into a further rotary position (c2) about the rotary axis (C), and again measured points in the measuring plane (E) on the upper surface (17) of the workpiece (16) are recorded. Based on these recorded measured points, the actual attitude (Li) of the workpiece (16) deviation from a specified target attitude (Ls) are determined. Adjustment parameters are determined, and an adjustment assembly (24) of the metrological apparatus (15) is activated as a function of the calculated adjustment parameters to adjust the workpiece (16).
US10239175B2 Vertical machining center
Provided is a vertical machining center including: a splash cover fixed to a base, the splash cover defining a machining chamber to enclose a machining zone; a column vertically standing on the base; a Z-axis guiding rail disposed on the column and being vertically directed toward the base, the Z-axis guiding rail partially exposed to the machining zone; a Z-axis driving device disposed in the column, the Z-axis driving device partially exposed to the machining zone; a spindle head to be driven vertically by the Z-axis driving device; a spindle head opening formed in the splash cover so that the spindle head can pass through the spindle head opening; and an extendable cover provided between an edge of the spindle head opening and the spindle head and configured to cover parts of the Z-axis guiding rail and the Z-axis driving device, the parts being exposed to the machining zone.
US10239173B2 Cutting apparatus
A cutting apparatus includes a cutting tool and a collection assembly designed for diverting, collecting and disposing dust generated during the cutting process. The apparatus includes a cutting tool, a collection assembly together with an optional dust separator and/or collection container. The air stream generated around the blade of the cutting tool during operation diverts the generated dust particulates into the collection assembly of the cutting tool. The air stream can also transport the dust into the dust separator which transfers the dust into the collection container, when present. Optionally, the collection container further includes an air filtration assembly for storing and disposing the dust.
US10239171B2 Cutting apparatus
A cutting apparatus includes a magazine including a holder to hold a machining tool. The holder includes a container, a magnetic body, and an intermediate member. The container holds a flange of the machining tool. The container includes in its bottom surface a first insertion hole through which a tool body of the machining tool is to be inserted. The magnetic body is disposed under the container. The magnetic body includes a second insertion hole through which the tool body is to be inserted. The intermediate member is disposed inside the second insertion hole. The intermediate member includes a third insertion hole through which the tool body is to be inserted. A length of the intermediate member in a height direction is equal to or longer than a length of the magnetic body in the height direction. The intermediate member is made of a non-magnetic material.
US10239170B2 Precision gun smith platform
A gun smith platform includes a top plate. The top plate has a tool hole centrally disposed on the top plate that extends through the top plate through which a work piece attached to a work tool mounted to a bottom side of the top plate may extend, a plurality of alignment holes extending in a linear pattern from the tool hole, the alignment holes configured to receive alignment pins, at least one row of threaded mounting holes disposed parallel to the linear pattern of alignment holes, and a recessed track disposed parallel to the at least one row of threaded mounting holes. Four legs are attached to and supporting the top plate.
US10239164B2 Robotic wire termination system
A robotic wire termination system for efficiently connecting a plurality of wires to an electrical connector. The robotic wire termination system generally includes a frame, a connector support attached to the frame, a robot manipulator having at least one arm, a heating device attached to the at least one arm and a control unit in communication with the robot manipulator to control the operation of the robot manipulator. The arm of the robot manipulator is adapted to move the heating device so that the heating device can apply heat to a selected connector pin of the electrical connector.
US10239163B2 Pipeline weld repairing method and apparatus
A method for repairing a defective circumferential weld joint between two pipe sections in a pipeline is described. A weld excavation machine is used to remove a weld defect. The machine comprises a weld excavating tool and a tool guiding apparatus. The machine may be modular in form allowing the machine to be dissembled into discrete portable parts. The method includes arranging the tool guiding apparatus in fixed relation to the pipeline, guiding the weld excavating tool around the pipe and along the weld joint by means of the tool guiding apparatus and using the weld excavating tool to remove material from the defective weld region. An excavation may thus be formed having parallel vertical walls. The excavation is then filled with weld material by means of a welding apparatus.
US10239159B2 Laser wire processing device
A wire guide and a laser wire-processing device that includes a wire guide are provided. The laser wire-processing device includes a housing and an aperture in a side of the housing, wherein the aperture defines a longitudinal axis that is substantially perpendicular to the aperture. The laser wire-processing device also includes a backstop arranged in the housing and aligned with the longitudinal axis, the backstop defining a wire-contact surface in a facing relationship with the aperture. The laser wire-processing device also includes a wire guide arranged in the housing to manipulate a wire inserted through the aperture into a desired position relative to the longitudinal axis between the aperture and the backstop. The laser wire-processing device also includes a laser operable to direct a laser beam toward an insulation layer of the wire. The wire guide could be a tube arranged in the device or a backstop guide.
US10239156B2 Multi-density, multi-property turbine component
A method of forming a metal component having different regions containing different grain sizes and in porosities is by additive manufacturing. The method includes spreading a layer of starting powder on a temperature controlled moveable platform in a heated chamber with atmosphere and temperature control. Selected areas of the powder are melted and solidified with a computer controlled focused energy beam. The cooled platform is then indexed down and the process repeated. The grain size of the melted and solidified region can be controlled by the cooling rate during solidification which, in turn is controlled by the temperature of the chamber and the temperature of the cooled moveable platform.
US10239155B1 Multiple laser beam processing
Described herein is a system for processing a workpiece that includes a plurality of lasers that each produces a laser beam pulse. The system also includes a laser control module that sequences temporal characteristics of the laser beam pulses. Additionally, the system includes a laser beam compensation module that shapes a near field intensity profile of at least one of the laser beam pulses and adjusts a path length of at least one of the laser beam pulses. The system also includes at least one laser beam position element that combines the laser beam pulses to produce a combined laser beam pulse at a surface of the workpiece.
US10239153B2 Inertia friction welding system for martensite-free joining of materials
A method for joining materials such as metal alloys that includes a first component, wherein the first component includes a first alloy having a known austenization temperature below which martensite forms when the component is heated and then cooled at a predetermined rate of cooling; a second component, wherein the second component includes a second alloy; and a welding apparatus operative to create a weld between the first and second components without crossing the austenization temperature of the first alloy. The method also includes the steps of validating the characteristics of the weld created between the first and second components in real-time during the welding process; modifying the welding apparatus to prepare the surface of the first component prior to welding to assure proper alignment of the first and second components; and/or physically modifying the second component to enhance the welding characteristics and durability thereof.
US10239152B2 Friction stir welding bobbin tool
A bobbin tool is disclosed that includes a top shoulder, a bottom shoulder, and an axial pin that extends between the top and bottom shoulders. The bottom shoulder has an annular shoulder end surface, a back surface opposite the annular shoulder end surface, and a side surface that joins the annular shoulder end surface and the back surface. One or more and radially-extending blades may be disposed on the side surface of the bottom shoulder and/or one or more axially-extending blades may be disposed on the back surface. The one or more blades provide the bobbin tool with an ability to friction stir weld a variable thickness workpiece assembly, axially plunged through the workpiece assembly along an axis of rotation of the bobbin tool, and/or be extracted through the workpiece assembly along an axis of rotation of the bobbin tool.
US10239151B2 Linear friction welding method
A method linear friction welds a rotor blade to a disk. The method includes: providing a linear friction welding machine having disk tooling at which a disk is mounted, and further having blade tooling at which a blade is mountable; mounting a dummy blade at blade tooling, dummy blade carrying one or more first measurement devices which interact with mounted disk to measure position of dummy blade relative to disk; adjusting position and orientation of blade tooling relative to mounted disk until first measurement devices indicate that dummy blade is in a suitable alignment with disk to start linear friction welding a blade to disk; releasing dummy blade from blade tooling and mounting a production blade thereat; and linear friction welding the production blade to the disk with the blade tooling starting at adjusted position and orientation.
US10239150B2 Ultrasonic welding of composites using C frame tooling
A number of variations may include a weld gun and a method of operating the weld gun including a motor operably coupled to a converter. The converter may be operably coupled to a booster. A horn may be operably coupled to the booster. An anvil may be operably coupled to the horn wherein vibration of the horn may be caused by the motor. Moreover, the vibration of the horn may produce heat in order to weld a piece which may be disposed adjacent to the horn. The weld gun may not require separate or additional tooling.
US10239146B2 Method and apparatus for welding with short clearing prediction
A method and apparatus for providing welding-type power is disclosed and includes a short clearing prediction module that uses the second derivative with respect to time of the output voltage, or an error between a measured output voltage and an output voltage predicted using the first derivative with respect to time of the output voltage.
US10239143B2 Slab scarfing apparatus and method for controlling the same
A slab scarfing apparatus comprises: an upper nozzle unit having an upper surface nozzle for scarfing an edge portion of the upper surface of a slab and having a first side nozzle scarfing an upper edge portion of the side surface of the slab and moving together with the upper surface nozzle; a lower nozzle unit having a lower nozzle for scarfing an edge portion of the lower surface of the slab and having a second side nozzle scarfing a lower edge portion of the side surface of the slab and moving together with the lower nozzle; and a moving apparatus for moving the upper nozzle unit and the lower nozzle unit to allow the upper nozzle unit and the lower nozzle unit to be adjacent to or to be spaced apart from an edge portion of the slab. A method of controlling the apparatus is provided.
US10239142B2 Multi-airfoil split and rejoin method to produce enhanced durability coating
A method for working an airfoil cluster is disclosed. The method may include attaching a first datum to a first portion of the airfoil cluster and a second datum to a second portion of the airfoil cluster; adding material to at least one of the first portion and the second portion; and joining the first portion to the second portion, the first and second datums substantially aligned in a common plane spaced away from the first and second portions.
US10239139B2 Method for machining a set of teeth, tool arrangement, and tooth-cutting machine
The invention relates to a method for machining a toothing, wherein to form a chamfer on a tooth edge formed between an end face of the toothing and a tooth flank belonging to a tooth space of the toothing, material is removed from the tooth edge by cutting, by means of a machining tool equipped with a cutting edge, in a machining operation, wherein the machining tool is toothed and the machining operation is a skiving machining operation at an axis intersection angle between the rotational axes of the machining tool and the toothing, which does not extend beyond the tooth root section of the tooth space.
US10239137B1 Reciprocating saw blade for preparing fish
This disclosure relates to a reciprocating saw blade for preparing fish. The reciprocating saw blade can comprise a blade and a wing. The blade can attach to a reciprocating blade. The blade can comprise a tip, a cutting edge, a spine, and a heel. The cutting edge can have continuous wavy serrations formed through a tooth from a plurality of teeth. The tip can form an inward curve towards the cutting edge. The cutting edge can be at one side of the blade while the spine can be at the opposite side. The spine can form an equidistant parallel line with the cutting edge. The heel can be at the rear end of the cutting edge. The wing can be at the rear end of the blade and can have an orifice and a prong. The orifice can be compatible to a quick-release mechanism of the reciprocating blade.
US10239135B2 Surgical saw mount and blade
There is disclosed a sagittal saw blade mount and corresponding sagittal saw blade. The blade mount is configured to rotationally oscillate along a plane of motion about an axis of rotation which passes through the blade mount crossing the plane of motion at a point of rotation. The blade mount comprises a securing portion comprising two securing faces passing through the plane of motion and a locking member configured to urge a blade towards the securing portion in a first direction parallel to the plane of motion, thereby securing the blade between the locking member and the securing faces. The two securing faces are angled such that the planes of the securing faces intersect with each other and with the plane of motion at a point of intersection which is positioned such that the point of rotation lies between the point of intersection and the securing portion.
US10239132B2 Machining tool
An attrition liner machining tool, configured to machine the surface of an attrition liner provided radially outward of a set of a plurality of fan blades in a gas turbine engine. The tool includes at least one rotating machine tool having a connector at a first end and a cutter at a second end. The connector is configured to rigidly connect to a rotating fan blade mount of the gas turbine engine that, in use of the gas turbine engine, supports the fan blades. The cutter is configured to machine the attrition liner. The at least one rotating machine tool is configured such that, when it is connected to said rotating fan blade mount of a gas turbine engine, the cutter is passed across the surface of the attrition liner when said rotating fan blade mount is rotated.
US10239129B2 Machine tool
Provided is a machine tool including: a bed; a work-table which is provided to the bed; a moving device provided to the bed; a spindle head provided to the moving device; at least a vertical main spindle provided to the spindle head, the vertical main spindle extending in the vertical direction; and at least a horizontal main spindle provided to the spindle head, the horizontal main spindle extending in a horizontal direction.
US10239124B2 Cutting insert
A cutting insert including a body having three vertices, an upper face, a lower face, and flank faces joining the upper and lower faces. At least one cutting edge is formed at an intersection between the upper face and the flank faces. A generally triangular-shaped island surrounds a central axis of the cutting insert and is higher in elevation than at least one portion of the upper face.
US10239122B2 Alloy nanoparticles, process for their preparation and use thereof
There is provided a process for preparing alloy nanoparticles having a desired size. The process comprises a combination of co-reduction of metal salts in the presence of a reducing agent, and multi-step seeded growth synthesis. Also provided is a material which comprises alloy nanoparticles made of at least two metals. A mean diameter of the particles of the material is between about 30 nm and 200 nm as measured by transmission electron microscopy (TEM), and the particles have a coefficient of variation smaller than about 15%.
US10239119B2 Apparatus for continuous slab casting
The apparatus for continuous slab casting having a nozzle exchanging-holding mechanism capable of moving a submerged nozzle at the exchange of the nozzle through a moving-connecting space D of a base under a slide valve mechanism and keeping the connection between the submerged nozzle and the slide valve mechanism during the operation, and a rotation mechanism to rotate the base of the nozzle exchanging-holding mechanism, which is characterized by a fixing mechanism that fixes the submerged nozzle in the nozzle exchanging-holding mechanism by pressing the submerged nozzle toward one or both inner sides of the moving-connecting space D of the base in one or both directions perpendicular to the moving direction of the submerged nozzle during the nozzle exchange.
US10239116B2 Solvent system and compositions therewith
The present invention relates to a solvent system characterized by the fact that is comprises one or more dioxolane-derived esters of formula I where R1, R2 and R3 are the same or different, selected from hydrogen, alkyl, alkenyl and phenyl, and n is an integer between 1 and 5.
US10239115B2 Method for joining at least two parts to be joined which are arranged so as to overlap at least in a joining zone using a joining element
A method for joining at least two parts to be joined which are arranged so as to overlap at least in a joining zone is disclosed using a joining element which is fed to the joining zone in a joining direction and which is designed so as to be free of undercuts at least in a shaft when seen opposite the joining direction. At least one first part to be joined that interacts first with the joining element in the joining direction, is punched by means of the joining element, and the joining element is pressed into a second part to be joined without punching through the second part. The shaft of the joining element is designed so as to be free of undercuts after being pressed into the second part to be joined and is arranged so as to contact the first and the second part to be joined with a radially applied force in a form-fit-free manner at least when seen opposite the joining direction.
US10239114B2 Systems and methods for transporting material
A system for transporting material is provided. The system includes a container and a robot having a material-handling device for inserting the material into the container and removing the material from the container. The system also includes a track assembly having a track and at least one platform on which the robot and the container are mounted such that the robot and the container are movable along the track via the at least one platform.
US10239110B2 Method of manufacturing a large- or medium-sized wheel disk and a product manufactured thereby
A method of manufacturing a large- or medium-sized wheel disk including using a punch or die in a first step of ironing a blank of a flat plate to a first-stage product. The first-stage product having a cylindrical rising portion with an axially non-constant thickness. The rising portion includes a thick portion located at a tip portion of the rising portion and a thickness-reduced portion which is a remaining portion of the rising portion excluding the thick portion. During the first step, only a portion of the blank corresponding to the thickness-reduced portion is ironed.
US10239105B2 Blank steel plate, production method and production device therefor, and production method for press-formed product using blank steel plate
A blank steel plate is planar and used for producing a press-formed product that has an open cross-section including a bent portion. The blank steel plate is homogeneous in its entirety and includes a belt-shaped thick area that has an increased thickness, thin areas that are adjacent to both sides of the thick area and have a thickness smaller than the thickness of the thick area. On the front surface of a front surface and a back face of the blank steel plate, a step height in thickness is formed along one of both side portions of the thick area, and on the back face, a step height a thickness is formed along the other of both side portions of the thick area. By using the blank steel plate in producing the press-formed product, it is possible to optimizing the strength of the press-formed product, and suppress manufacturing costs.
US10239104B1 Device for removing dents
A tool for removing dents includes a rigid member having first upper handle and a second lower handle extending in a generally opposite direction and interconnect by way of a first lateral rigid bar portion, a second rigid upper bar portion connects to the first lateral bar portion and extends generally in a common direction to the first upper handle thus forming a U shape between the first upper handle, the first lateral rigid bar portion and the second rigid upper bar portion, and a rigid nose head extending from an end of the second rigid bar portion inward generally in a direction toward the first upper handle.
US10239101B2 Purge device and method of diffusing gas including purge gas
A purge device includes an internal space defined by a chassis, and performs a purge process where an inside of a storage container in the internal space with an article being accommodated is purged with a purge gas. The purge device includes an air blower that is located outside the chassis, and sends air to an area where a gas including the purge gas in the internal space leaks through an opening in the chassis so as to diffuse the gas including the purge gas leaking from the opening.
US10239097B2 Method and apparatus for the recovery and regeneration of metal powder in EBM applications
The present invention relates to a method and an associated apparatus (1) for the recovery and regeneration of metal powder in EBM (Electron Beam Melting) applications. The method is of the type which envisages a step for recovery of weakly sintered powders inside a cleaning chamber (2) incorporating at least one compressed-air nozzle with supply, where necessary, of powder for sandblasting three-dimensional objects obtained by means of EBM sintering of the metal powders; according to the invention it is envisaged supplying into the cleaning chamber (2) metal powders having a predetermined low oxygen content and there is also a powder recirculating system (3) comprising at least one first buffer tank (9) inside which the regenerated powders are deposited for renewed supply of the aforementioned chamber (2).
US10239096B2 Base plate assembly transfer mechanism and methods
This invention relates to an apparatus for processing a baseplate assembly and more specifically to a transfer mechanism and a parts washer for processing baseplate assemblies. The transfer mechanism has a pivot arm that is mounted to a transfer and/or lift mechanism. The pivot arm holds a carrier unit having an abutment plate and a finger. The finger having an extended state and a retracted state relative to the abutment plate. The finger engaging and securing the baseplate assemblies to the carrier unit during the transport of the baseplate assemblies from a welder or tapper to a parts washer. The transfer mechanism picks the baseplate assemblies from the welder or tapper in a horizontally extending alignment and deposits the baseplate assembly in the parts washer in a vertically extending alignment. The parts washer then washes the baseplate assemblies, while the baseplate assemblies remain in a vertically extending alignment.
US10239089B2 Product portion enrobing process and apparatus
An apparatus for enrobing a product portion can include a polymer spray head arranged to direct a plurality of polymeric fibers in an upward direction and levitate product portions in a polymer enrobing zone above the polymer spray head. Polymeric fibers produced by the polymer spray head can wrap around the product portions levitated in the polymer enrobing zone to create an enrobed product. Side guide structure(s) and/or air knife(s) can be provided adjacent to the polymer enrobing zone to inhibit levitated product portions from falling out of the polymer enrobing zone and/or to guide levitated product portions along a desired path. Exemplary enrobed products include smokeless tobacco products.
US10239086B2 Garden fountain
The garden fountain includes a lower container, a middle container and an upper container. A water pump positioned in the lower container pumps water up into the middle container. The upper container rests in the middle container. Using a combination of the water level in the middle container and the spacing of the bottom of the upper container with respect to the water level in the middle container, the user can accurately control the water flow to the upper container.
US10239085B2 Aseptic aerosol misting device
A handheld misting device has a housing having a dispensing window is arranged and configured to contain a sonic generator, a power source coupled to the sonic generator, at least one reservoir containing a liquid, and a conduit extending from the at least one reservoir to a nozzle removably coupled to the sonic generator. The sonic generator includes a converter and an elongate horn having a proximal end coupled to the converter and a distal end, and the nozzle is removably coupled to the distal end of the horn. Thus, the device delivers the liquid through a delivery opening formed in the nozzle, and activating the sonic generator energizes the liquid in the nozzle to generate an aerosol plume that is delivered through the dispensing window.
US10239084B2 Methods and devices for jetting viscous medium on workpieces
An apparatus for depositing and/or jetting viscous medium on a surface of a workpiece includes at least two depositing head assemblies. The at least two depositing head assemblies are configured to move in three dimensional space. The at least two depositing head assemblies are also configured to at least one of concurrently and simultaneously deposit the viscous medium on the workpiece.
US10239076B2 Peristaltic pump and trailer mounted self pumping sprayer system incorporating same
A sprayer system having a trailer, which is pulled by a tractor or other tow body, and has a tank carrying liquid to be sprayed and a spray head. The trailer has a peristaltic pump mounted on a frame and driving pumping power from the wheels of the trailer so that the sprayer is self pumping when the trailer is pulled. The peristaltic pump provides a smooth flow by providing a multiplicity of pulses of liquid produced by the pump from the rotation of the trailer wheels by wrapping the compressible tube of each pump around an assembly of rollers which are rotated by drive wheels. The tube is wrapped at least 360° around the rollers and is held stationary by being connected to fixed outlet and inlets of each pump. The tube lies side by side on at least one of the rollers of each assembly and overlaps that roller.
US10239075B2 Nozzle gun and lever lock mechanism
A nozzle gun includes a nozzle main body, an operating member attached to the nozzle main body to be movable toward and away from the nozzle main body, and a stopper attached to the nozzle main body to be pivotable between a locked position and a non-lock position and having a locking portion and receptacles, wherein when the operating member is moved toward the nozzle main body and the stopper is placed in the locked position, the locking portion engages with the operating member to prevent the operating member from moving away from the nozzle main body, when the stopper is in the non-lock position, the locking portion does not engage with the operating member, and when the operating member is moved toward the nozzle main body with the stopper in the non-lock position, the operating member presses the receptacles to cause the stopper to pivot into the locked position.
US10239070B2 Impeller for electrostatic spray gun
An alternator, such as for use in an electrostatic spray gun, comprises an electromagnetic alternator, a housing and an impeller. The electromagnetic alternator has a shaft. The electromagnetic alternator is disposed within the housing. The housing has an air aperture. The impeller is mounted to the shaft within the housing so as to be aligned with the air aperture. The impeller includes blades having curved leading and trailing edges. In one embodiment, each blade has a curvature so as to be perpendicular to the air aperture across an entire arc over which each impeller blade has a line of sight of the air aperture.
US10239068B1 Portable spreader for particulate matter
A gravity-feed spreader for particulate matter may include a rotor. The spreader may be operable for gravity-feed operation with the longitudinal axis of the rotor in a horizontal position. A generally cylindrical rotor housing with a pair of closed, axial ends may be coaxial with the rotor. Entrance and exit apertures for the particulate matter may be formed in the surface of the rotor housing between the closed, axial ends. A rotor driver may be coupled to the rotor shaft for rotating the rotor. An intake housing may include a passageway therethrough for the particulate matter. A gate may be provided for selectively opening and closing the particulate matter passageway in the intake housing. An agitator may be coupled to the rotor shaft for facilitating movement of particulate matter through the passageway in the intake housing.
US10239066B2 Orbital sprinkler with speed control brake
A sprinkler head includes a sprinkler body, a nozzle positioned within the sprinkler body, a fixed gear coupled with the sprinkler body, a wobbler cage supported on the sprinkler body, and a water deflector plate coupled with the wobbler cage and disposed downstream of the nozzle. A brake assembly is coupled with the water deflector plate for slowing a rotating and wobbling motion of the wobbler cage and the water deflector plate. The brake assembly includes a shaft extending through the water deflector plate and a brake gear disposed at an end of the shaft, where the brake gear is engageable with the fixed gear. Among other advantages, the design eliminates the use of large fixed strut framework that creates dry shadows in the water pattern.
US10239060B2 Thermocycling system, composition, and microfabrication method
A system and method of manufacture for the system, comprising a set of heater-sensor dies, each heater-sensor die comprising an assembly including a first insulating layer, a heating region comprising an adhesion material layer coupled to the first insulating layer and a noble material layer, and a second insulating layer coupled to the heating region and to the first insulating layer through a pattern of voids in the heating region, wherein the pattern of voids in heating region defines a coarse pattern associated with a heating element of the heating region and a fine pattern, integrated into the coarse pattern and associated with a sensing element of the heating region; an electronics substrate configured to couple heating elements and sensing elements of the set of heater-sensor dies to a controller; and a set of elastic elements configured to bias each of the set of heater-sensor dies against a detection chamber.
US10239059B2 Thermal cycler cover
In one aspect, a thermal cycler system is disclosed. The thermal cycler can be comprised of a device housing and a cover that is operably connected to the device housing. The cover can include a handle portion, a device lid portion, a sample block platen, and a link bar. The device lid portion is attached to the proximal side of the handle portion with a first pin. The sample block platen is operably connected to the handle portion such that the sample block platen is positioned against the sample block when the handle portion is flush with the device lid portion and the cover is in a closed position. The link bar is pivotably connected to the device housing at a first terminal end portion and a second pin at an opposite second terminal end portion, wherein the handle portion is elevated away from the device lid portion before the cover is moved to an open position.
US10239052B2 Synthesis of molecular sieves having MWW framework structure
The present invention provides an improved method for making molecular sieves having MWW framework structure using precipitated aluminosilicates (PAS), and the use of molecular sieves so made in processes for catalytic conversion of hydrocarbon compounds.
US10239051B2 Catalyst compositions comprising small size molecular sieves crystals deposited on a porous material
A catalyst composition contains an inorganic porous material with pore diameters of at least 2 nm and of crystals of molecular sieve. The crystals of molecular sieve have an average diameter, measured by scanning electron microscopy, not bigger than 50 nm. The catalyst composition has a concentration of acid sites ranges from 50 to 1200 μmol/g measured by TPD NH3 adsorption. An XRD pattern of the catalyst composition is the same as an XRD pattern of the inorganic porous material.
US10239044B2 Carbohydrate-mediated purification of petrochemicals
A separation medium consisting of a cyclodextrin metal-organic framework (CD-MOF) for separating aromatic compounds and methods of preparing the same are presented. Bottom-up preparations include the following steps: (a) preparing a first mixture comprising a cyclodextrin, an alkali metal salt, water and an alcohol; (b) performing one of the following two steps: (i) stirring the first mixture; or (ii) adding an amount of a surfactant to the first mixture to form a second mixture; and (c) crystallizing the CD-MOF from the first mixture or the second mixture. Top-down preparations include the following steps: (a) preparing a first mixture comprising the cyclodextrin, an alkali metal salt, water and an alcohol; (b) crystallizing the CD-MOF from the first mixture; and (c) optionally performing particle size reduction of the crystallized CD-MOF. The CD-MOFs are amenable for use in methods for separating alkylaromatic and haloaromatic compounds from a mixture of hydrocarbons.
US10239043B2 Vinylidene chloride copolymer-based carbon molecular sieve adsorbent compositions and processes therefor
Novel carbon molecular sieve (CMS) compositions comprising carbonized vinylidene chloride copolymer having micropores with an average micropore size ranging from 3.0 to 5.0. These materials offer capability in separations of gas mixtures including, for example, propane/propylene; nitrogen/methane; and ethane/ethylene. Such may be prepared by a process wherein vinylidene chloride copolymer beads, melt extruded film or fiber are pretreated to form a precursor that is finally carbonized at high temperature. Preselection or knowledge of precursor crystallinity and attained maximum pyrolysis temperature enables preselection or knowledge of a average micropore size, according to the equation ?=6.09+(0.0275×C)−(0.00233×T), wherein ? is the average micropore size in Angstroms, C is the crystallinity percentage and T is the attained maximum pyrolysis temperature in degrees Celsius, provided that crystallinity percentage ranges from 25 to 75 and temperature in degrees Celsius ranges from 800 to 1700. The beads, fibers or film may be ground, post-pyrolysis, and combined with a non-coating binder to form extruded pellets, or alternatively the fibers may be woven, either before or after pre-treatment, to form a woven fiber sheet which is thereafter pyrolyzed to form a woven fiber adsorbent.
US10239042B2 Method for producing a functional ceramic material
A functional ceramic material made from a raw material mixture which includes 0.1-0.5 wt % iron powder, 20-25 wt % bentonite, and a remainder of sludge (based on dry weight) which contains bacteria. To make the functional ceramic material, the raw material mixture is calcined at low temperature and anaerobic conditions. Use of the material for purifying a medium is also provided.
US10239041B2 Carbonation device and method of carbonation using the same
Disclosed is a carbonation device including: a storage tank storing a carbonation subject solution; a droplet spray unit spraying the carbonation subject solution from the storage tank as droplets; a carbonation reaction tank disposed with the droplet spray unit and filled with a carbonation gas under a predetermined pressure to provide a slurry by a carbonation reaction of the droplet-sprayed carbonation subject solution with the filled carbonation gas; a carbonation gas supply unit supplying the carbonation gas into the carbonation reaction tank to maintain the carbonation gas in the carbonation reaction tank under the predetermined pressure; and a slurry outlet unit ejecting the slurry from the carbonation reaction tank to maintain the slurry formed in the carbonation reaction tank within a predetermined level, and a method of carbonation using the same.
US10239040B2 Flow reactor vessels and reactor systems
The present invention discloses high pressure flow reactor vessels and associated systems. Also disclosed are processes for producing thiol compounds and sulfide compounds utilizing these flow reactor vessels.
US10239036B2 Solar thermochemical reactor, methods of manufacture and use thereof and thermogravimeter
A solar thermochemical reactor includes an outer member, an inner member disposed within an outer member, wherein the outer member surrounds the inner member and wherein the outer member has an aperture for receiving solar radiation and wherein an inner cavity and an outer cavity are formed by the inner member and outer member and a reactive material capable of being magnetically stabilized wherein the reactive material is disposed in the outer cavity between the inner member and the outer member.
US10239035B2 Solar thermochemical reactor, methods of manufacture and use thereof and thermogravimeter
A solar thermochemical reactor includes an outer member, an inner member disposed within an outer member, wherein the outer member surrounds the inner member and wherein the outer member has an aperture for receiving solar radiation and wherein an inner cavity and an outer cavity are formed by the inner member and outer member and a reactive material capable of being magnetically stabilized wherein the reactive material is disposed in the outer cavity between the inner member and the outer member.
US10239031B2 Apparatus and method for mixing fluids with degradational properties
An apparatus and method for mixing fluids with degradational properties are disclosed herein. The present system has been devised to safely and accurately dilute, heat and deliver a degradable fluid while simultaneously removing extraneous vapor, adding capability to monitor the temperature and capability to monitor the concentration of the diluted fluid.
US10239030B2 Pharmacy formulation production system and pharmacy formulation production method for producing pharmaceutical individual formulations
A pharmacy formulation preparation system (2) for preparing individual pharmaceutical formulations such as formulations for ointments, semisolid preparations, eye drops, lotions, pills, capsules or teas in quantities of up to 5 kg, according to the invention comprises: reading means (8); weighing means (12); mixing means (14), in particular a stirrer having a drive and a mixing container; display means (10); a data processing unit (4) adapted to have access to data in a pharmacy-associated stock database area (6); a preparation database (18) comprising composition information; and that for the read-in individual prescription data of an individual prescription, by accessing the preparation database (18), the raw materials required for preparing the individual prescription and the respective quantities thereof as well as the time period, the processing devices and the procedure parameters of the mixing procedure can be determined.
US10239024B2 Method for the production of a filtration membrane having a mean molecular weight cut-off of < 1000 g/mol
The invention relates to a process for preparing a filtration membrane having an average molecular out-off of <1000 g/mol.
US10239023B2 Self-wetting porous membranes (II)
Disclosed is a self-wetting porous membrane comprising an aromatic hydrophobic polymer such as polysulfone and a wetting agent comprising a copolymer of formula A-B or A-B-A, wherein A is a hydrophilic segment comprising a polymerized monomer of the formula (I): CH2═C(R1)(R2), wherein R1 and R2 are as described herein, and B is polyethersulfone, wherein segments B and A are linked through an oxygen atom. Also disclosed is a method of preparing a self-wetting membrane comprising casting a solution containing an aromatic hydrophobic polymer and the wetting agent, followed by subjecting the cast solution to phase inversion. The self-wetting porous membrane finds use in hemodialysis, microfiltration, and ultrafiltration.
US10239022B2 Porous calcium-silicates and method of synthesis
Mesoporous membranes have shown promising separation performance with a potential to lower the energy consumption, leading to a dramatic cost reduction. Recently, an extensive effort has been made on the design of membranes which brought a significant progress toward the synthesis of well-defined porous morphologies, most of which synthesized by surfactant-template methodology. Currently, the most well-designed state-of-the-art membranes using this technique are made from metals, polymers, carbon, silica, etc. In the present invention, we demonstrate mesoporous calcium-silicate particles having superior separation capacity and optimal permeability, thereby leading to reduced energy consumption for selective separation of gases/liquids and/or the combination thereof. We explore various methods to improve the calcium-silicate membranes properties by tuning pore density during the synthesis/aging process, while favoring the formation of uniformly distributed nanopores. Lowering particle density by controlling calcium to silicon ratio along with optimizing the surface area are essential in achieving our objective.
US10239021B2 Fouling resistant coating for filtration membranes and methods of producing and using same
A conformal coating that resists fouling by waterborne contamination in aquatic environments, a method for fabricating the coating, and a filter having such a coating are disclosed. The coating comprises a hydrophilic polymer and a surfactant wherein the surfactant undergoes a phase change upon exposure to a saline solution. Also disclosed are in situ methods for regenerating anti-fouling filters having the fouling resistant coating.
US10239019B2 Reverse-osmosis-membrane device and method for operating the same
Provided are reverse-osmosis-membrane device capable of treating raw water including a large amount of membrane foulants, such as MBR-treated water, with stability while preventing a reduction in the amount of permeate, and a method for operating the reverse-osmosis-membrane device. The raw water includes a high-molecular organic substance having a molecular weight of 10,000 or more at a concentration of 0.01 ppm or more. The reverse-osmosis-membrane device includes a reverse-osmosis-membrane element including a membrane unit, the membrane unit including a reverse osmosis membrane having a thickness of 0.1 mm or less, a feed spacer disposed on a surface of the reverse osmosis membrane, and a permeate spacer disposed on the other surface of the reverse osmosis membrane. The reverse-osmosis-membrane device is operated at a permeation flux of 0.6 m/d or less.
US10239007B2 Air filter assembly
An air filter assembly having a primary filter element, a secondary filter element, and a housing with an outlet tube is disclosed. The primary filter element is operably installed within the housing and has an interior volume. The secondary filter element is operably installed within the primary filter element interior volume and has an interior volume defined by a first wall extending between a closed end cap and an opposite open end cap. The open end cap of the secondary filter element defines a sealing structure having a first portion extending into the secondary filter interior volume. The outlet tube is operably connected to the housing air outlet opening and includes an inset collar being at least partially disposed within the secondary filter interior volume and extending over at least a part of the sealing structure first portion.
US10239003B2 Polymer nanofiber accumulated body and method of producing the same
Provided is a nanofiber accumulated body having a high mechanical strength and excellent in durability, the polymer nanofiber accumulated body including polymer nanofibers each containing a polymer material, the polymer nanofibers being accumulated and three-dimensionally entangled with each other to form the accumulated body, in which: the polymer nanofibers each have a fiber diameter of 3 μm or less; and the polymer nanofibers each contain 5 wt % to 30 wt % of a low-molecular weight organic compound having at least one α,β-unsaturated ester structure, with respect to a total weight of the polymer nanofibers.
US10239001B2 Filter having a filter cartridge, and corresponding filter cartridge
A filter assembly includes a filter body, a removable filter cartridge, and the bypass valve with incinerable and non-incinerable portions. The bypass valve includes a valve seat and a movable valve closure element removable with the removable filter cartridge and incinerable. The bypass valve includes a return member remaining in the filter body. A method is provided for controlling bypass valve-opening threshold pressure.
US10238996B2 Underdrain assembly and method of manufacturing same
An underdrain apparatus and a method for manufacturing such apparatus are provided. The underdrain apparatus can be extruded in long sections as a unitary part. The underdrain apparatus may be extruded in various sizes, shapes, and materials. Further, the underdrain apparatus may include a passageway for transporting water to and from the filter media and/or air to the filter media. In some embodiments, apertures are formed in the underdrain apparatus during an extrusion process to provide a path between the passageway and the filter media.
US10238995B2 HDS channel exit designs for improved separation efficiency
Hydrodynamic separation of suspended particles using curved channels offers advantages in many applications, since it is a fast continuous flow technology that can handle neutrally and near neutrally buoyant particles without the need of a physical barrier or the addition of chemical aids. Designs are provided for a flow splitter at the end of the separation channel, to maintain smooth, counter-vortex-free laminar flow and improve particle separation efficiency while reducing clogging and fouling propensities.
US10238993B1 Dual screen treatment systems with debris ramps and screened deflectors
Vaults, boxes, systems, and methods of treatment systems to capture pollutants from storm water runoff and prevent the conveyance of these pollutants from entering a receiving water body or landscape area, which is designed to be a part of a local permanent storm water drainage infrastructure. A single treatment box, vault and system combines both drainage conveyance, multi-level treatment techniques, variable hydraulic capabilities, and easy and inexpensive methods for servicing the system. A flow spreader having a triangular shape with straight sides, or concave sides or convex sides can split incoming water to pass into dual screen filtration systems. Additionally, an upwardly angled debris ramp above a downwardly angled screened defector can be located on both sides of the flow spreader to help direct debris and trash into dual screened boxes. The system can also include components selected from a shelf beneath the spreader, at least one baffle, skimmer, deflectors, media filtration and hydroslide water pressure lines with spray heads for cleaning debris on a sloped floor.
US10238991B2 Cleanout device and method
A device and method for removing hot molten wax or other material from a receptacle for a meltable tart or the like. The device has a heat resistant body formed of a material that is of sufficient porosity to absorb or soak up the hot molten wax or other material in the receptacle when it is positioned therein and to retain its structural integrity so that it can be disposed of after it has absorbed or soaked up the hot molten wax or other material.
US10238990B2 Apparatus for removing contamination via electrodes and a two-layered filter comprising carbon and an activating agent
Contaminants are filtered from a fluid flow stream and the filter is regenerated by a process including steps of: providing a filter material comprising both carbon and potassium iodide; passing a contaminated fluid stream in contact with the filter material; adsorbing contaminants from the fluid stream onto surfaces in the filter material; passing an electric current through the filter material with adsorbed contaminant thereon; disassociating contaminant from the surfaces of the filter material; and removing disassociated contaminant from the filter material by carrying away the disassociated contaminant in a fluid flow mass.
US10238986B2 Flying disc
A flying disc includes a substantially circular body having a top and a bottom and a groove extending around a perimeter of the body between the top and the bottom. The top of the body has an edge member around the outer perimeter of the top, and a domed portion in a central area of the top. A portion of the top between the edge member and the domed portion is inwardly curved. The bottom has an edge member around the outer perimeter of the bottom, a substantially planar portion in a central area of the bottom, and an inwardly curved portion between the edge member and the substantially planar portion.
US10238984B2 Water toy
A water toy comprising a foam tube having a first end, a second end and a body therebetween, an optional seat positioned on the body, a first feature attached to the first end, and a second feature attached to the second end, the first and second features being aesthetic and/or functional and/or a combination of the same.
US10238983B1 Self-righting toy
A wobbling toy is configured to spontaneously re-orient itself in an upright position solely under the force of gravity. The self-righting toy includes a weight that is confined to and movable along a pathway such that the weight defines a dynamic mass that is sufficient to cause the housing to spontaneously pivot along a convex outer surface profile in coordination with a position of the weight in the pathway. The self-righting toy is configured to maintain a positional relationship of the weight so that the housing is spontaneously pivotable along the convex surface without external force supplied by a user.
US10238980B2 Vertical wind tunnel skydiving simulator
A vertical wind tunnel skydiving simulator including a flight chamber entrance that has a curved air deflector that extends into a waiting chamber, in which a convex surface of the curved air deflector faces across or towards the flight chamber entrance or into the flight chamber, and extends into the waiting chamber a sufficient distance to substantially reduce the flow of turbulent air into the waiting chamber. The curved surface is at the top of the entrance and can also be at the sides. The shape the curved surface takes is sufficient to minimize the flow of turbulent air into the waiting chamber; the effect is to make it more comfortable and less noisy for people in the waiting area. This also helps to preserves the laminar, non-turbulent flow of air in the flying chamber, even across the flight chamber entrance. This makes flying more comfortable and predictable.
US10238978B2 Game operating device
A game operating device (controller) includes a longitudinal housing, and a holding portion held by hand to be wrapped by its palm it is formed in the housing. A direction switch is provided on an upper surface at a position where it can be operated by thumb of the hand holding the holding portion, and a start switch and a select switch are provided backward thereof. An X button 46 and a Y button are further arranged in line on the upper surface of the housing. An imaging information arithmetic unit is provided at a front end of the housing in a longitudinal direction in such a manner that an imaging device thereof is exposed from a front-end surface. A concave portion is formed on a lower surface at a position corresponding to the direction switch. The concave portion includes a valley and two inclined surfaces. An A button capable of being operated by index finger of the hand holding the holding portion is provided on the backward inclined surface. By processing an image signal obtained by imaging an infrared ray from LED modules by the imaging device, it is possible to obtain an operation signal varying according to a position and/or attitude of the controller.
US10238970B2 Game processing system, game processing program, and game processing method
A game processing system that controls a display to display a plurality of graphic forms each indicating an identifier; identifies a trajectory of a continuously drawn input selecting a plurality of the graphic forms; identifies the identifiers of the graphic forms corresponding to the input trajectory; identifies at least a first command based on an arrangement of the identifiers when detecting an end of the input; and controls a game operation of attacking an opponent based on the command.
US10238966B2 Method and apparatus for estimating the value of an input in presence of a non-linear factor
The present invention concerns a method and a device for estimating the value of an input in a real-time system. It concerns more particularly real time interactive systems where the input is tracked using a first sensor, typically a camera in presence of a perturbing factor. The perturbing factor is estimated using a second sensor. The component of input computed values due to the perturbing factor are cancelled based on this estimation. A next input value is then estimated from the previous computed input values where the perturbing factor has been cancelled. The estimation is then corrected by applying back the estimation of the perturbing factor.
US10238964B2 Information processing apparatus, information processing system, and information processing method
There is provided an information processing apparatus including a waveform generation unit configured to generate a waveform according to a relative movement between two objects in a virtual space, and an output control unit configured to control a haptic output and a sound output on the basis of frequency distribution of the waveform generated by the waveform generation unit.
US10238962B2 System and method for recharging battery in augmented reality game system
In an aspect, an augmented reality game system is provided including a mobile smart device such as a smart phone and a remotely controlled drone. The mobile smart phone device is programmed to display an augmented environment, being the real environment viewed by the camera and a virtual environment superimposed over images of the real environment. The drone is controlled via commands transmitted wirelessly by the mobile smart device. The mobile smart device is programmed to execute a video game, which includes activities requiring a player to control the drone in relation to the augmented environment displayed on the mobile smart device video screen. The drone is powered by a rechargeable battery, and the video game includes activities that keep the player occupied with the game while the drone's rechargeable battery recharges.
US10238961B2 Toy system comprising toy elements that are detectable by a computing device
A toy system comprising one or more toy elements configured to be detectable by a touch screen when brought within a proximity of the touch screen; and a computing device configured to: detect said one or more toy elements within a proximity of the touch screen; detect, in addition to detecting said one or more toy elements, one or more further touch events on the touch screen in a first predetermined spatial relationship to the detected one or more toy elements; and responsive to the detection of said one or more further touch events on the touch screen in said first predetermined spatial relationship to the detected one or more toy elements, to cause a user-perceptible output.
US10238960B2 Dual input multilayer keyboard
Aspects of the technology described herein provide an input mechanism that allows a user to select characters for input to a text area of a computing interface. The technology can be implemented as a virtual keyboard. Selecting a single output for the keyboard requires a user to provide two inputs. Each input is provided with reference to a different layer. Providing the first input to the first layer activates a second layer specific to the key selected with the first input. Each key in the first layer can be associated with a unique second layer. The output (e.g., a character) is determined from the second layer by providing a second input. The combination of the first and second input selects the ultimate output. In one aspect, the first input and the second input only have a directional component.
US10238955B2 System and method for delivering playing cards
A method of delivering cards from a card housing unit during a card game including automatically detecting, using one or more processors, at least one of a card being held within an opening in the card housing unit for a period of time longer than a predetermined period of time or an attempt to manually draw a card from the opening after the card game ends, and based on the automatic detection, controlling, using one or more processors, operation of a lock member to restrict movement of the card relative to the opening in the card housing unit.
US10238952B2 Roller board with one or more user-maneuverable trucks and north-seeking return mechanism
A roller board device like a skateboard or scooter operated by a user with one or more user-maneuverable wheel assemblies that are automatically returned to their “true north” position is provided according to the invention. The roller board device comprises an elongated deck, at least one wheel assembly, a rotation assembly operatively engaging and extending through the opening in the deck, one end of the rotation assembly being connected to the wheel assembly positioned below the deck, the other end of the rotation assembly being connected to a user interface member extending upward beyond the top surface of the deck, and a north-seeking return mechanism secured to the deck containing an engagement member movable along a linear axis within a housing and engaging a spring disposed between the engagement member and an interior wall of the housing, the rotation assembly operatively connected to the engagement member to convert rotational movement of the rotation member into linear movement of the engagement member. When the user applies rotational force to the user engagement member to turn it to the left or right, the rotation assembly and wheel assembly are rotated in the same direction and degree to allow the roller board device to be turned, the rotated rotation assembly interacting with the engagement member of the north-seeking return mechanism to move the engagement member along its linear axis to a retracted position to compress the spring. But, when the user releases the rotational force upon the user interface member, the spring extends from its compressed state to its elongated state to move the engagement member of the north-seeking return mechanism back along the linear axis from its retracted position to its standby position, counter interacting with the rotation assembly to return the wheel assembly of the roller board device to its true north position.
US10238947B2 Golf aid including virtual caddy
A golf aid system for assisting a user with a golf shot on a golf course includes a user tracking system configured to determine the location of the user on the golf course, a portable electronic device with a display screen, and a processor. The processor, which is operable to communicate with the user tracking system and the portable electronic device, is configured to determine one or more target locations on the golf course, with each of the target locations representing a recommended target for a respective one of the golf clubs. The processor directs the portable electronic device to display an indicator of the respective golf club proximate the corresponding target location via the display screen, such that the user perceives at least a portion of the indicator to be coincident with the corresponding one of the target locations.
US10238934B2 Golf club grip
A grip for a putter-type golf club including a bottom end having a recess to receive a golf shaft, and a top end opposite the bottom end. The recess defines a longitudinal axis, and an exterior side surface extends about the circumference of the longitudinal axis. The exterior side surface defines a generally planar portion and a generally arcuate portion adjoining the planar portion. A grip cross-section no greater than 15 mm from the top end includes a planar portion cross-sectional width no less than 4 mm, a first cross-sectional length, L1, and a maximum cross-sectional width located at a depth D1 from the planar portion such that D1/L1 is no greater than 0.40. According to another aspect, a grip cross-section between 120 mm and 140 mm from the top end includes a cross-sectional maximum width, W3, and a cross-sectional length, L3, such that W3/L3 is no greater than 0.90.
US10238923B1 Golf putter
A golf putter includes a head and a shaft. The head has a head body having a top surface that is formed with a mounting groove. The shaft has a main body portion and a connecting portion connected to the main body portion. The connecting portion is inserted into the mounting groove, is movable along the mounting in a longitudinal direction, and has a non-circular cross-section, such that the connecting portion is non-rotatable relative to the mounting groove of the head.
US10238919B1 Chemiluminescent swim fins
This invention is chemiluminescent swim fin system which allows one to swim at night or be worn at parties. It can be seen from behind has a large surface area for fin visibility. Its chemical composition allows it to be rapidly be recharged by lights, and exhibit bright visible light from a distance, but also allows for structural integrity of the material when used by swimmers.
US10238918B1 Platform-agnostic avalanche airbag attachment system
A platform-agnostic buoyancy aid includes a bladder having a direction of inflation, an inflator coupled to the bladder and configured to fill the bladder with a gas in response to actuation by a trigger, a trigger connected to the inflator and configured to actuate the inflator in response to a tension applied to a ripcord, and a removable directional attachment rig holding the bladder, inflator and trigger, the removable directional attachment rig configured to attach the buoyancy aid to at least one of a wearer's backpack, clothing or harness such that the relative angle of the direction of inflation of the bladder to the wearer's centerline remains substantially constant.
US10238909B1 Chest mounted, adjustable, exercise device
A chest mounted, adjustable, exercise device comprising a base plate, a forward extension rail coupled to the base plate, an adjustment slide coupled to the forward extension rail, a track slide coupled to the adjustment slide, and a resistive means being coupled to the forward extension rail.
US10238903B2 Residential concealed sprinkler
An automatic fire protection sprinkler includes a sprinkler body having a passage with an inlet end and a discharge opening. A pair of sprinkler arms extend from the sprinkler body. The pair of sprinkler arms each include a radially inwardly extending leg including a threaded bore for receiving a compression screw. The pair of sprinkler arms each include a radially outwardly extending leg each defining an aperture therein. An outlet closure assembly includes a closure element that selectively blocks the discharge opening of the sprinkler body and a trigger assembly including a yoke that engages the compression screws and a glass bulb that extends between the yoke and the closure element. A deflector is coupled to the sprinkler arms by a pair of support pins that are received in the apertures in the radially outwardly extending legs of the at least two sprinkler arms.
US10238901B2 Cargo fire-suppression agent distribution system
A cargo-fire-suppression agent distribution system and methods are presented. A fire-warning signal indicating presence of fire in a cargo compartment onboard a class E cargo aircraft at a first altitude is received. An initial fire-suppression agent is distributed in the cargo compartment at the first altitude sufficient to suppress fire for an initial fire suppression time interval during a depressurization phase during which the class E cargo aircraft flies to a second altitude below the first altitude. A re-enforcing fire-suppression agent is distributed in the cargo compartment during a re-pressurization phase when a cabin altitude is below a predetermined cabin pressure level (PL) during which the class E cargo aircraft flies from the second altitude to a landing, after the initial fire-suppression time interval elapses. The re-enforcing fire-suppression agent distribution is maintained during a re-enforcing fire-suppression time interval.
US10238897B2 Use of a lysate of bifidobacterium species for treating sensitive skin
Cosmetic use of an effective amount of at least one lysate of at least one microorganism of the genus Bifidobacterium species and/or a fraction thereof, for preventing and/or treating a skin disorder in the case of sensitive skin.
US10238896B2 Oral care compositions
This application provides, among other things, novel aqueous oral care compositions useful for combining and delivering poorly compatible ingredients, for example to deliver effective levels of cationic antibacterial agents in combination with short chain polyphosphate salts that protect against erosion and staining, by addition of a stabilizing amount of an anionic surfactant and methods for making and using the same.
US10238893B2 Dose rate modulated stereotactic radio surgery
The present disclosure relates to methods and systems for radiotherapy. Embodiments of the present disclosure may receive a medical image including images of a target and an organ at risk (OAR). Some embodiments may also receive a target dose and a constraint on an OAR dose. Some embodiments may also generate a dose application plan based on the target dose and the constraint. Generation of the dose application plan may include determining a placement of an arc along which radiation is to be applied based on the target dose and a location of the target; dividing the arc into a plurality of segments; determining a dose rate associated with each segment; calculating a predicted OAR dose based on the determined dose rate; and comparing the predicted OAR dose with the constraint on the OAR dose to determine whether the predicted OAR dose satisfies the constraint on the OAR dose.
US10238891B2 Device and method for improving brachytherapy
This invention is a medicament delivery vehicle, the vehicle comprising tubular members adapted to removably receive the medicament and an expandable stent adapted to receive the tubular members. Also provided is a medicament delivery vehicle, the vehicle comprised of tubular members which receive the medicament wherein the medicament comprises discrete entities and each of said entities are removably positioned at predetermined regions within the members.
US10238889B2 Apparatus and methods for phototherapy
There is provided a phototherapy apparatus, in which the therapeutic light is delivered through or in proximity to one or more massage components. The massage component provides mechanical massage to the subject biological tissue and modifies the properties of the subject tissue in thickness, density, etc. to facilitate the absorption of the therapeutic light and enhance the effect of the phototherapy procedure.
US10238885B2 Outpatient health emergency warning system
A medical system for sensing a physiological state requiring defibrillation in a patient. The system comprising: a low power sensor, a physiological parameter measuring device, and a processor. The low power sensor generating a baseline signal relating to a physiological status of said patient. The physiological parameter measuring device comprising at least one higher power sensor configured to output at least one physiological parameter signal indicative of at least one physiological parameter of said patient. The processor assessing the baseline signal and determining if the physiological status is outside predetermined threshold boundaries.
US10238884B2 Cardiac-safe electrotherapy method and apparatus
A multi-modal electrotherapy apparatus including circuitry for administering defibrillation therapy and for administering medium voltage therapy (MVT) adapted to reduce the side effects of MVT. The electrotherapy apparatus is configured to selectively deliver MVT to vectors not involving the ventricles and defibrillation therapy to vectors involving the ventricles. The apparatus can use biphasic waveforms configured to avoid capture of cardiac cells during MVT. The electrotherapy apparatus can minimize the risk of applying MVT at inappropriate times, such as during atrial fibrillation or where conventional ventricular tachycardia or ventricular fibrillation therapy is more appropriate.
US10238878B2 Hybrid communication channel for communicating with a medical device
An apparatus comprises a communication channel comprising a plurality of disparate sequential communication links configured to facilitate bi-direction communication between an implantable medical device (IMD) and a programmer. A transceiver is configured to communicate with the programmer via a first communication link of the plurality of disparate communication links. A telemetry device is configured to communicate with the IMD via a second communication link of the plurality of disparate communication links. A third communication link communicatively couples the transceiver and the telemetry device. A power source is coupled to the transceiver and to the telemetry apparatus. An operational status of at least the first and second communication links can be individually determined in real-time.
US10238876B2 Stimulation aggressor management for biomedical signal acquisition systems
Techniques, devices, and systems for isolating, by isolation circuitry connected to a power source, a voltage from the power source, receiving, by sensing circuitry, the isolated voltage, receiving, by the sensing circuitry, a reference voltage from an implantable reference electrode via a reference node, and sensing, by the sensing circuitry, the biomedical signal with two or more implantable sensing electrodes using the isolated voltage with respect to the reference voltage.
US10238875B2 Systems and methods for hypertension control
Systems and methods for hypertension control via energy delivery to one or more nerves affecting blood pressure are provided. Systems may include implantable devices configured for non-contacting neuromodulation. Implantable devices may be configured for intravascular implantation. Systems may also include external devices configured to communicated with implantable neuromodulation devices, Additional systems may include non-implantable devices for delivering modulation energy and ablation energy to one or more nerves affecting blood pressure.
US10238871B2 Implantable medical device arrangements
Embodiments presented herein are generally directed to arrangements for implantable medical devices. The implantable medical devices may include one or more of a single-body calvaria implant and an implantable microphone subcutaneously implanted in the recipient's forehead region.
US10238867B2 Pulsed electromagnetic field tissue stimulation treatment and compliance monitoring
A system and method for PEMF tissue engineering enhances musculoskeletal tissue stimulation by monitoring treatment for compliance with treatment regimens. A PEMF device includes sensors that detect attributes indicating whether the PEMF device is in use. The PEMF device also includes communication devices that connect it with other devices. The data obtained from the sensors may be used to determine a level of compliance in use of the tissue engineering device with a prescribed treatment regimen for the patient. The data is transferred via a paired UE to a remote server. The remote server stores the data in a database and periodically generates compliance reports. The compliance reports are shared with subscribing access devices including the prescribing physician. The UE pairing with the PEMF device maintains a treatment calendar and dynamically modifies reminders based on current treatment status. The treatment regimen may be updated and sent to the PEMF device.
US10238865B2 Electrode fixation in interventional medical systems
An implantable medical device assembly includes a mounting structure, an electrode protruding from a surface of the structure, between opposing sides thereof, and tissue-penetrating fixation tines, each extending from a corresponding shoulder of the structure surface, adjacent to the opposing sides. In a relaxed condition, each tine extends away from the surface and then bends toward a proximal end of the structure and back toward the surface. In an extended condition, each tine bends toward a distal end of the structure and extends along the corresponding shoulder. A holding member of a delivery tool has opposing sidewalls defining a cavity, wherein each sidewall includes a rail-like edge that fits in sliding engagement with a corresponding shoulder, to deform a corresponding tine into the extended condition, when an operator passes the assembly into the cavity. Applying a push force, to move the assembly back out form the cavity, releases the tines.
US10238856B2 Port and surface cleaning devices and techniques
This disclosure describes example antimicrobial compositions that may be used in combination with IV port cleansing caps, protective caps, or both. According to another implementations, the disclosure describes various cap devices that may be used in combination with the antimicrobial composition to cleanse, sanitized, and/or disinfected a surface.
US10238855B2 Connector with seal element and adapted connector parts
Certain aspects of the invention relate to a connector including at least one first connector part and at least one second connector part. The connector parts can be connected to one another in a fluid-tight manner and can be locked to one another via at least one closure element. One of the connector parts has at least one sealing element (e.g., a septum or a sealing disk) that blocks a throughflow in the closed state and which can be opened, and the other one of the connector parts has at least one opening element for opening the sealing element. One of the connector parts has at least one projection and the other one of the connector parts has at least one receiver, and the opening element and the sealing element are arranged with respect to one another such that the opening element only opens the sealing element when the projection has been introduced into the receiver.
US10238854B2 Methods for forming a tube assembly utilizing a joining agent
A method for joining a flexible tube to a connector having a female fitting that allows relatively facile connection and desirable retention force in a short amount of time. Tube assemblies having a tube bonded to the female fitting of the connector with a joining agent composition including an evaporable liquid hydrocarbon are disclosed.
US10238851B2 Medical access ports, transfer devices and methods of use thereof
A medical system, comprising an implantable access port including an implantable access port body and at least one implantable access port needle; wherein the at least one needle is concealable inside the access port body in a concealed position and is exposable outside the access port body in an exposed position; wherein the at least one needle is arranged within the access port body to penetrate outwardly through skin of a subject from within the subject when the access port is implanted in the subject; a transfer device coupled to the at least one needle of the access port, the transfer device configured to transfer a fluid to and/or from the access port; and wherein the transfer device is configured to form a closed system with the access port, wherein the transfer device includes a fluid flow passage configured to transfer the fluid to and/or from the access port.
US10238850B2 Systems and methods for radiographically identifying an access port
An access port for subcutaneous implantation is disclosed. Such an access port may comprise a body for capturing a septum for repeatedly inserting a needle therethrough into a cavity defined within the body. Further, the access port may include at least one feature structured and configured for identification of the access port subsequent to subcutaneous implantation. Methods of identifying a subcutaneously implanted access port are also disclosed. For example, a subcutaneously implanted access port may be provided and at least one feature of the subcutaneously implanted access port may be perceived. Further, the subcutaneously implanted access port may be identified in response to perceiving the at least one feature. In one embodiment, an identification feature is included on an insert that is incorporated into the access port so as to be visible after implantation via x-ray imaging technology.
US10238849B2 Sonotrode
Disclosed are a sonotrode and its use for transdermal delivery of therapeutic or cosmetic compounds. The sonotrode 10 comprises a tubular neck 14 attached at a proximal end to a solid head 12 and ending at a distal end in a flared foot 16. When coupled to an ultrasonic transducer and applied to skin of a human or animal, the sonotrode enhances the delivery of compounds into the skin.
US10238848B2 Solvent-cast microprotrusion arrays containing active ingredient
In an aspect of the invention, an array of microprotrusions is formed by providing a mold with cavities corresponding to the negative of the microprotrusions, casting atop the mold a first solution comprising a biocompatible material and a solvent, removing the solvent, casting a second solution atop the first cast solution, removing the solvent from the second solution, and demolding the resulting array from the mold. The first solution preferably contains an active ingredient.
US10238846B2 Sinus balloon dilation catheters and sinus surgery tools
Inventive embodiments disclosed herein include a catheter for dilating a sinus cavity lumen. The catheter includes a guide tube, having a proximal end and a distal end, that terminates in a distal tip; a sleeve member annularly positioned over the guide tube, wherein the sleeve member is movable relative to the guide tube and is capable of being advanced over the guide tube; and a balloon coupled to the sleeve member, wherein the balloon can be extendable and inflated at or beyond the end of the guide tube.
US10238843B2 Variable displacement inflation devices and methods of use
An inflation device that may comprise multiple plungers is disclosed. The inflation device may have multiple configurations wherein certain plungers are locked with respect to a body of the inflation device while others are configured to be displaceable within the body. Each plunger may be configured with a different effective surface area, allowing a practitioner to vary the amount of force required to attain certain pressures.
US10238839B2 Pulmonary artery head catheter holder
A catheter holder assembly for selectively holding a portion of a one or more catheter tubes to a head of a user. Comprising head mount assembly, a one or more catheter holders, the one or more catheter tubes, a catheter. The one or more catheter holders comprise a first catheter holder. The one or more catheter holders are attached to the head mount assembly. Head mount assembly is configured to releaseably attach to the head of the user. The one or more catheter holders releaseably hold the one or more catheter tubes. The one or more catheter tubes each comprise the catheter at a first end being a downstream of the one or more catheter holders and an IV bag at a second end being an upstream of the one or more catheter holders. The catheter is configured to attach to a portion of the user at an insertion point.
US10238834B2 Catheter
Catheters and methods for supporting a guidewire or delivering a radiopaque, diagnostic or therapeutic agent through a vessel stenosis or other tortuous anatomy are disclosed. A catheter can comprise an elongate shaft body and a tip member disposed at a distal end of the shaft body. The shaft body can extend from a proximal end to the distal end and can define an inner lumen. The shaft body can include a liner, a braid member surrounding the liner, a multi-layer coil surrounding the braid member, and a polymer cover surrounding the multi-layer coil. An outer surface portion of the polymer cover can include one or more helical threads, which can be enveloped in an outer wrapper. The tip member can be made from a metal or a polymer. Polymer tip members can include a hard or semi-hard distal tip.
US10238833B2 Access port and catheter assembly including catheter distal portion stability features
A stabilized catheter tube for insertion into a body of a patient. The catheter tube includes a distal portion that remains stable during fluid infusion into the patient, thus reducing or eliminating whipping of the catheter distal tip. In one embodiment, the catheter tube defines at least one lumen and is formed from a tube material that defines a proximal portion and a distal portion of the catheter tube. The catheter tube is configured such that the arithmetic product of an elastic modulus and an area moment of inertia for the distal portion of the catheter tube is greater relative the arithmetic product of an elastic modulus and an area moment of inertia for the proximal portion of the tube. In one embodiment, the catheter tube is operably attached to an implantable access port and includes an enlarged distal portion relative a proximal portion of the catheter tube.
US10238832B2 Catheter assembly and a method and system for producing such an assembly
A catheter assembly is disclosed, comprising a catheter, such as a urinary catheter, which at least a partly is provided with a hydrophilic coating. The catheter assembly further comprises a wetting fluid. The receptacle is in direct contact with the hydrophilic coating of the catheter over essentially the entire length of the part of the catheter being provided with the hydrophilic coating. This may e.g. be achieved by using a shrink wrap material. In order to accomplish adequate wetting, channels or the like may be provided on the inner surface of the receptacle or the outer surface of the catheter.
US10238828B2 Nasal cannula, conduit and securement system
Medical breathing tubes have a tubular body that defines a lumen extending between open terminal ends of the tubular body. An internal form is enclosed within the lumen and supportive of the tubular body. The internal form may be a coated encapsulated internal form where the coating secures the internal form to the tubular body. The internal form may provide for a series of alternative crests and troughs of the tubular body. A patient interface and/or a securement system may be attached to the tubular body.
US10238826B2 Respiratory mask
This invention relates to a respiratory mask for delivering an inhalation fluid to the airways of a wearer. The respiratory mask includes a body of generally concave shape and having a peripheral edge, the body being adapted to provide a cavity in use about the mouth and nose of a wearer such that the inhalation fluid can be inhaled by the wearer from the cavity. The respiratory mask includes a resilient seal formation depending from at least a portion of the peripheral edge. The resilient seal formation includes both an inwardly and outwardly depending lip portion relative to the peripheral edge of the body. The mask may accommodate a range of facial dimensions whilst still retaining an effective seal.
US10238825B2 Cushion assembly for a respiratory mask
A mask cushion or a mask assembly therewith provides a comfortable and effective seal for provision of a gas therapy by a respiratory treatment apparatus. The mask cushion (102) may be integrated with or coupled to a mask frame. The mask cushion typically includes an inner cushion component (104). The mask cushion also includes a patient facial-contact side portion with a chamber (108) and a barrier (106) to form the chamber that may be flexible. The chamber may serve as an outer layer with respect to the inner cushion component. The chamber may be partially or completely filled with a gas, fluid or gel. The inner cushion may be formed with a soft flexible material such as an elastomer or foam, etc. The barrier may be a membrane and may also be soft flexible material.
US10238824B2 Pressure equalization balloon and method for the production thereof
The volume of a pressure equalization balloon is connected to a further volume, the pressure of which is intended to remain as constant as possible. To keep the cuff pressure in the pressure range of between roughly 20 mbar and 30 mbar, the equalization balloon is produced from a thermoplastic polymer (TPE) and is overstretched past the maximum intended control volume before first use and is then relaxed to the range of the control volume.
US10238823B2 Gas mixing control apparatus and method
A ventilator includes first and second pathways, a conduit and a controller. The first pathway (120) is configured to supply a first gas and the second pathway (140) is configured to supply a second gas, where the second gas is mixed with the first gas to produce mixed gas having a predetermined percentage of the second gas. The conduit (166) is configured to provide the mixed gas from the first and second pathways to an access port during an inspiratory phase, and to provide discharged gas from the access port to the first pathway during an expiratory phase. The controller (180) is configured to delay supply of the second gas from the second pathway for a delay time in order to maintain the predetermined percentage of the second gas in the mixed gas provided to the access port during a subsequent inspiratory phase.
US10238821B2 Inhaler and methods of use thereof
A medicament delivery device comprises a dosing chamber configured to contain dry powder medicament, a transducer and a controller electrically coupled to the transducer. The medicament delivery device is capable of delivering a therapeutically effective dose of dry powder medicament in response to between 2-20 tidal inhalations, the dose preferably having a mass median aerodynamic diameter (MMAD) of about 6 microns or less and a fine particle fraction of at least 30%.
US10238817B2 Prefilled syringe
A prefilled syringe includes: a syringe barrel including a syringe barrel body and an outer barrel; a cap; a gasket; and a plunger which allows the gasket to slide by pressing a press portion located on the base end of a shaft to discharge a drug solution inside the syringe barrel body. The outer barrel has a window and a mask which hides the inside of the outer barrel on a wall thereof. A part of the shaft has a mark which has a color different from the color of other parts of the plunger. The mark is covered with the mask and is not visually recognizable through the window before discharge of the drug solution. The outer peripheral surface of the mark is visually recognizable through the window along with movement of the plunger when the discharge of the drug solution is completed.
US10238816B2 Devices and methods for forming vascular access
The invention generally relates to catheter systems and methods for guided formation of vascular access sites (such as fistulas and grafts). According to certain aspects, a catheter system for forming a vascular access site include an elongate body comprising a distal end and configured to be inserted into a first vessel. The elongate body includes an exit port along its side that is proximal to the distal end. An imaging assembly is associated with the elongate body and configured to generate image data of the first vessel and a second vessel positioned next to the first vessel. For vascular access formation, a penetrating member of the catheter system extends out of the exit port and through a wall of the first vessel and a wall of the second vessel.
US10238815B2 Puncture assisting device and puncture device set
A puncture assisting device includes a pair of plate-like pinching portions that face each other, and that are attached to each other so as to be openable and closeable; a biasing portion that biases the pair of pinching portions to be in a closed position; a pair of gripping portions configured to operate the pair of pinching portions to be in an open position; and a rod insertion portion that is disposed between the pair of pinching portions, the rod insertion portion being configured such that a rod portion of a syringe is insertable into the rod insertion portion to widen a gap between the pair of pinching portions.
US10238812B2 Skin treatment systems and methods using needles
A device for treating the skin comprises a handpiece assembly having a distal end and a proximal end and a tip on the distal end of the handpiece assembly. The handpiece assembly includes a fluid delivery conduit, a waste conduit and/or an energy delivery conduit. Further, the tip is configured to contact the skin. The tip comprises a peripheral lip and a plurality of needles generally positioned within the peripheral lip. The tip also comprises at least one opening in fluid communication with a fluid delivery conduit, at least one opening in fluid communication with a waste conduit and/or an energy contact point in electrical communication with an energy contact point and energy conduit in the main body portion. The plurality of needles may be movable with respect to the peripheral lip through the use of a pneumatic or other force.
US10238801B2 System and method for configuring a rule set for medical event management and responses
A system and method to configure a rule set used in connection with a medical monitoring system for monitoring patients and patient care equipment, especially medication delivery pumps, based on a variety of conditions and parameters associated with monitored biometric information and equipment information and for providing user-defined responses to those conditions and parameters.
US10238798B2 Pressurizable fluid supply apparatus
A pressurizable fluid supply apparatus may include a bag to hold a fluid. The bag may include a fluid outflow interface and a bladder positioned adjacent to the bag. The bladder may include a plurality of chambers positioned vertically in series. Adjacent chambers may be separated by dividers. The dividers may be configured to allow fluid flow between adjacent chambers under specified conditions. The bladder may further include a pressure inlet positioned at a top of the bladder.
US10238795B2 Device for drug delivery
Disclosed is an ambulatory therapeutic fluid delivery device. The device includes at least one housing connectable to a cannula, the at least one housing retaining a reservoir to hold the therapeutic fluid. The device also includes a mechanically powered pumping mechanism to cause delivery of at least some of the fluid from the reservoir, and a power-transfer mechanism to transfer manually-delivered power provided by a user to mechanically actuate the pumping mechanism.
US10238793B2 Precision syringe pump and manufacturing method thereof
A precision syringe pump employing a syringe comprises a motor, a lead screw and a syringe driving head connected to the lead screw. The syringe comprises a cylinder and a plunger. The motor drives the lead screw to rotate clockwise or counterclockwise to drive the syringe driving head and push the plunger to move within the cylinder. The syringe pump further comprises: a magnetoresistive sensor, at least one permanent magnet and an MCU, the at least one permanent magnet being located on the lead screw and rotating therewith; the magnetoresistive sensor can sense the magnetic field generated by the at least one permanent magnet; the input end of the MCU is connected to the magnetoresistive sensor, and the output end of the MCU is connected to the motor; the MCU receives signals from the magnetoresistive sensor and controls, according to the signal feedback, the direction and velocity of the lead screw rotated by the motor. The precision syringe pump of the present invention is characterized by high sensitivity, high reliability, low power consumption and low cost, and is convenient to use.
US10238792B1 Connector bracket IV pole top
An intravenous (IV) pole assembly comprising: an IV pole having a pole, a plurality of hooks mounted to the pole, and a base with a plurality of wheels, wherein the plurality of hooks are for holding a container of intravenous fluid; and a decorative equipment including a decorative element and a connector bracket attached to the decorative element, the connector bracket for mounting on a top of the pole, the connector bracket comprises a shaft that defines a plurality of slots on one end of the shaft.
US10238787B2 Blood component separation device
A blood reservoir (20) for storing blood includes a first storage section (21), a second storage section (22), and a third storage section (23) that is provided between the first storage section and the second storage section, and communicates with the first storage section and the second storage section. A volume of the blood reservoir (20) can be adjusted by changing the amount of expansion or contraction of a bellows structure (28) using a bellows adjustment mechanism (83, 93).
US10238784B2 System and method for peritoneal dialysis
The invention relates to a system of performing an evidence Dialysis modality of Batch, Tidal or a combination of both. The system: isolates cavity volume changes due only to ultrafiltrate; determines the volume of a patient cavity; determines a full cavity; determines an objective time to initiate an exchange; and determines an empty cavity. One or more combination of these features provide for evidence base Fill, Dwell, and Drain sequences. The system comprises: a cassette having a heated region and a sensor region for measurements. A valve manifold supplies a patient connection with fluid. A microprocessor receives pressure measurements, controls the heated region and activates a volumetric pump to deliver or extract discrete increments of the fluid to the cassette from bags. Filtering pressure measurements to remove rapid fluctuations determines an accumulated pressure in the patient cavity. The volume of fluid in the patient cavity correlates to the accumulated pressure.
US10238783B2 Guidable intravascular blood pump and related methods
An improved intravascular blood pump and related methods involving the broad inventive concept of equipping the intravascular blood pump with guiding features such that the intravascular blood pump can be selectively positioned at a predetermined location within the circulatory system of a patient.
US10238780B2 Delivery-and-fluid-storage bridges for use with reduced-pressure systems
Systems, methods, and apparatuses are presented that facilitate the provision of reduced pressure to a tissue site by using a delivery-and-fluid-storage bridge, which separates liquids and gases and provides a flow path for reduced pressure. In one instance, a delivery-and-fluid-storage bridge includes a delivery manifold for delivering reduced pressure to a treatment manifold at the tissue site and an absorbent layer proximate the delivery manifold adapted to receive and absorb liquids. The delivery manifold and the absorbent layer are encapsulated in an encapsulating pouch. A first aperture is formed proximate a first longitudinal end of the delivery-and-fluid-storage bridge for fluidly communicating reduced pressure to the delivery manifold from a reduced-pressure source, and a second aperture is formed on a patient-facing side of the delivery-and-fluid-storage bridge. Reduced pressure is transferred to the tissue site via the second aperture. Other systems, apparatuses, and methods are disclosed.
US10238778B2 Automatically switching different aspiration levels and/or pumps to an ocular probe
Methods and apparatuses for automatically switching different aspiration levels to an ocular probe are disclosed herein. The probe may be a phacoemulsification probe. A first aspiration level, supplied by a first pump, may be applied to the probe simultaneously with ultrasonic energy. A second aspiration level, supplied by a second pump, may be automatically switched from the first aspiration level. Control feed back of the pumps may be varied according to set thresholds.
US10238776B2 Hydrophobic catheter and composition
In various embodiments, a surgical catheter is provided. The catheter may comprise one or more hydrophobic barrier layers made from an ethylene-pertfluoroethylenepropylene (“EFEP”) copolymer. Additionally, the catheter may comprise another polymer layer made from a reactive polar polymer. In at least one embodiment, the reactive polar polymer may be a modified-poly(ether block amide) (“PEBA”) copolymer, such as an amine-terminated PEBA. Moreover, in various embodiments, a composition is provided that may comprise a reactive polar polymer bonded to an EFEP copolymer.
US10238773B2 Methods of making collagen fiber medical constructs and related medical constructs, including nerve guides and patches
The disclosure describes methods of winding collagen fiber to make medical constructs and related collagen fiber tube and patch devices.
US10238772B2 Biodegradable composite scaffold for repairing defects in load-bearing bones
A tissue scaffold for repair and regeneration of bone hard tissue or muscle, skin, or organ soft tissue, including load-bearing bone tissue, the scaffold comprising a core of biocompatible, biodegradable inorganic glass fibers; and a biocompatible, biodegradable, flexible polymer film surrounding the core and adhered to the core.
US10238771B2 Methods for treating bioprosthetic tissue using a nucleophile/electrophile in a catalytic system
Methods for treating a bioprosthetic tissue are described herein. The methods comprise contacting the bioprosthetic tissue with at least one nucleophile and/or at least one electrophile in the presence of a catalytic system comprising at least one or a combination of a fluoride-based salt, a cesium-based salt, a potassium-based salt, a rubidium-based salt, or a carbonate-based salt. The methods may be used to alter functional groups on biological tissue which represent actual and potential calcium binding sites and also processes for cross-linking bioprosthetic tissue. Both processes may be used in conjunction with known fixative techniques, such as glutaraldehyde fixation, or may be used to replace known fixative techniques.
US10238770B2 Reparative cell isolation and delivery
Methods are described for generating autologous tissue grafts, including generating grafts at the point of care, which include isolated cell populations that are enriched with stem cells and are mixed with biological fillers including hyaluronic acid and derivatives thereof. The hyaluronic acid localizes the cells to a desired injection site and stimulates collagen production thus enhancing the viability and the longevity of the graft.
US10238768B2 Wound-healing and hemostatic sponge of squid ink polysaccharide/chitosan, preparation method and use thereof
A wound-healing and hemostatic sponge of squid ink polysaccharide/chitosan, a preparation method and use thereof are provided. The sponge comprises squid ink polysaccharide and chitosan as carriers and calcium chloride as an initiator for blood coagulation, and the wound-healing and hemostatic sponge of squid ink polysaccharide/chitosan is achieved via a lyophilization technology. Particularly, the preparation method comprises slowly adding a squid ink polysaccharide solution to a chitosan solution to form a uniformly mixed solution, adding a calcium chloride solution to the uniformly mixed solution, forming a gel followed by the gel being frozen and then lyophilized, and achieving the product. The wound-healing and hemostatic sponge has a good absorbing-errhysis effect, a good pro-coagulant effect, fast hemostasis and a complete hemostatic effect, without secondary re-hemorrhage. Moreover, the wound-healing and hemostatic sponge can promote wound healing, re-epithelialization and repair of epidermis and dermis, with strong wound-healing ability, good biocompatibility, weak toxic side effects and irritation, belonging to a novel wound-healing and hemostatic material. Moreover, the preparation method is reliable, fast, and low cost.
US10238764B2 Aromatherapy vaporization device
A novel herbal vaporization device (HVD) and method is disclosed. The HVD includes a recharging unit for storing therein of a vaporization unit having a heating chamber disposed at a first end thereof for receiving of loose leaf herbal material and for providing of heat thereto, the vaporization unit comprising a second end disposed opposite the first end with a fluid pathway between the two ends. In a first mode of operation the vaporization unit is for being recharged from the recharging unit and in a second mode of operation the vaporization unit is for use in vaporizing of loose leaf herbal material inserted into the heating chamber for having at least partially vaporized loose leaf herbal material and ambient air to flow through the fluid pathway.
US10238763B2 Sterilizing floor array
Various devices for sterilizing a surface and an object in contact with the surface are disclosed. For example, a first device includes an ultraviolet light source, a touch sensor, a processing system, and a computer-readable medium. The computer-readable medium stores instructions which, when executed by the processing system, cause the processing system to perform operations that include detecting, via the touch sensor, a tactile state of the device, detecting a tactile state of at least one additional device, determining, based upon the tactile states, that the device is on an edge of a pattern of contact between an object and a surface comprising the device and the at least one additional device, and implementing an action associated with the ultraviolet light source in response to determining that the device is on the edge of the pattern of contact.
US10238759B2 Power supply connector for a submersible pump and light source
A method of supplying power to a storage tank, can include attaching a power supply connector to a submersible pump wherein the power supply connector is dispersed between a pump motor and a pump head or wherein the power supply connector is dispersed above the pump head, wherein the submersible pump is located within a storage tank, wherein the storage tank comprises a decontamination region containing fuel and an ultraviolet light source located in the decontamination region; supplying power to the pump motor, wherein the pump motor power simultaneously supplies power to the ultraviolet light source; and irradiating the fuel with the ultraviolet light.
US10238757B2 Methods and compositions for detection of cancer
A molecular probe for use in detection of cancer cells expressing an Ig superfamily cell adhesion molecule that binds in a homophilic fashion in a subject includes a targeting agent that specifically binds to and/or complexes with a proteolytically cleaved extracellular fragment of the Ig superfamily cell adhesion molecule.
US10238748B2 Anti-CDH6 antibody drug conjugates
The present invention relates to anti-CDH6 antibodies, antibody fragments, antibody drug conjugates, and their uses for the treatment of cancer.
US10238735B2 Controlled activation of complement components for use as endogenous adjuvant
The invention relates to a pharmaceutical composition made of one or more preparation and comprising a therapeutically effective dose of at least one recombinant human C3-derivative and at least one antigen für vaccination.
US10238734B2 Compositions and methods for self-adjuvanting vaccines against microbes and tumors
The present invention is drawn to compositions and methods to enhance an immune response in order to prevent or treat infections or hyperproliferative diseases such as cancer. More particularly, the composition is an immunostimulatory intracellular signaling peptide fused directly or indirectly to a peptide that leads to multimerization into complexes of three or more units, where the intracelluar signaling peptide must be present in a complex of three or more units in order to stimulate an immune response. Inserting this fusion construct into viruses like HIV-1 or introducing it into dendritic cells or tumor cells is predicted to lead to a positive therapeutic effect in humans, non-human mammals, birds, and fish.
US10238733B2 Cationic oil-in-water emulsions
This invention generally relates to cationic oil-in-water emulsions that can be used to deliver negatively charged molecules, such as an RNA molecule. The emulsion particles comprise an oil core and a cationic lipid. The cationic lipid can interact with the negatively charged molecule thereby anchoring the molecule to the emulsion particles. The cationic emulsions described herein are particularly suitable for delivering nucleic acid molecules (such as an RNA molecule encoding an antigen) to cells and formulating nucleic acid-based vaccines.
US10238732B2 RSV F protein mutants
The present disclosure relates to RSV F protein mutants, nucleic acids or vectors encoding a RSV F protein mutant, compositions comprising a RSV F protein mutant or nucleic acid, and uses of the RSV F protein mutants, nucleic acids or vectors, and compositions.
US10238731B2 Chikagunya virus RNA vaccines
The disclosure relates to tropical diseases such as viral mosquito borne illnesses and the treatment thereof. The invention includes ribonucleic acid vaccines and combination vaccines, as well as methods of using the vaccines and compositions comprising the vaccines for treating and preventing tropical disease.
US10238727B2 Peptides and combination of peptides for use in immunotherapy against prostate cancer and other cancers
A method of treating a patient who has prostate cancer includes administering to said patient a composition containing a population of activated T cells that selectively recognize cells in the patient that aberrantly express a peptide. A pharmaceutical composition contains activated T cells that selectively recognize cells in a patient that aberrantly express a peptide, and a pharmaceutically acceptable carrier, in which the T cells bind to the peptide in a complex with an MHC class I molecule, and the composition is for treating the patient who has prostate cancer. A method of treating a patient who has prostate cancer includes administering to said patient a composition comprising a peptide in the form of a pharmaceutically acceptable salt, thereby inducing a T-cell response to the prostate cancer.
US10238725B2 Peptides and combination of peptides for use in immunotherapy against CLL and other cancers
The present invention relates to peptides, proteins, nucleic acids and cells for use in immunotherapeutic methods. In particular, the present invention relates to the immunotherapy of cancer. The present invention furthermore relates to tumor-associated T-cell peptide epitopes, alone or in combination with other tumor-associated peptides that can for example serve as active pharmaceutical ingredients of vaccine compositions that stimulate anti-tumor immune responses, or to stimulate T cells ex vivo and transfer into patients. Peptides bound to molecules of the major histocompatibility complex (MHC), or peptides as such, can also be targets of antibodies, soluble T-cell receptors, and other binding molecules.
US10238724B2 Peptides and combination of peptides for use in immunotherapy against CLL and other cancers
The present invention relates to peptides, proteins, nucleic acids and cells for use in immunotherapeutic methods. In particular, the present invention relates to the immunotherapy of cancer. The present invention furthermore relates to tumor-associated T-cell peptide epitopes, alone or in combination with other tumor-associated peptides that can for example serve as active pharmaceutical ingredients of vaccine compositions that stimulate anti-tumor immune responses, or to stimulate T cells ex vivo and transfer into patients. Peptides bound to molecules of the major histocompatibility complex (MHC), or peptides as such, can also be targets of antibodies, soluble T-cell receptors, and other binding molecules.
US10238723B2 Autologous tumor lysate-loaded dendritic cell vaccine for treatment of liver cancer
The present disclosure provides compositions comprising mature dendritic cells loaded with autologous tumor cell lysates for the treatment of liver cancers, such as hepatocellular carcinoma. Hepatocellular carcinoma (HCC) is the fifth leading cancer and third leading cause of cancer-related mortality worldwide. Surgical resection and liver transplantation remain the mainstay of effective therapy for patients with early disease. However, a prevalent problem with HCC is the high likelihood of initial diagnosis at an advanced stage.
US10238722B2 Pigment epithelium derived factor (PEDF) for the treatment of uterine fibroids
A method of treating uterine fibroid in a subject in need thereof is provided. The method comprising administering to the subject a therapeutically effective amount of pigment epithelium-derived factor (PEDF), thereby treating the uterine fibroid in the subject.
US10238717B2 Parenteral glucagon formulations
This invention relates to compositions of glucagon suitable for administration by manual injection or by an insulin pump or other injection device to treat hypoglycemia. Said compositions comprise glucagon and a sugar, have a final pH between about 1.5 and 3, and are gel-free, chemically-stable at body temperature and pump-able.
US10238716B2 Anti-P2X7 peptides and epitopes
The invention relates to the identification of a novel epitope on non-function P2X7 receptors which are implicated in cancer. The epitope includes a region from two adjacent monomers within the three subunit receptor. Antibodies which bind to the epitope and peptides for generating the antibodies are described. The antibodies and peptides are useful in the diagnosis and treatment of cancer.
US10238714B2 Method for forming an immune-tolerant site and method for attracting immunosuppressive cells
A method for forming an immune-tolerant site, and a method for attracting immunosuppressive cells, comprising contacting an agent comprising SEK-1005 (Ser, 3-hydroxy-N-[2-hydroxy-1-oxo-2-tetrahydro-2-hydroxy-6-methyl-5-(2-methylpropyl)-2H-pyran-2-yl-propyl]-Leu-Pip(hexahydro-3-pyridazinecarbonyl)-N-hydroxy-Ala-N-methyl-Phe-Pip-rho-lactone) and/or fibroblast growth factor (FGF) with a site in the body tissue.
US10238711B2 Extracellular histones as biomarkers for prognosis and molecular targets for therapy
Hyper-inflammatory responses can lead to a variety of diseases including sepsis. It is now shown that extracellular histones released in response to inflammatory challenge are mediators contributing to endothelial dysfunction, organ failure and death during sepsis. As such, they can be targeted pharmacologically by inhibitors, as well as used as biomarkers for prognosis of sepsis and other diseases.
US10238709B2 Method of treating diseases
Methods of treating acromegaly in a subject are described herein. Exemplary methods include orally administering to the subject at least once daily at least one dosage form comprising octreotide, wherein the octreotide in each dosage form is 20 mg, and wherein the administering occurs at least 1 hour before a meal or at least 2 hours after a meal.
US10238700B2 Oncolytic virus adjunct therapy with agents that increase virus infectivity
Provided are adjunct therapies for use in combinations and compositions with an oncolytic virus, such as a vaccinia virus. The adjunct therapies include co-administration and co-formulation of a complement inhibitor and/or a lipid emulsion composition with the oncolytic virus. Also provided herein are therapeutic methods using the adjunct therapies for treatment of disease and conditions employing an oncolytic therapeutic virus, such as for the treatment of hyperproliferative diseases or conditions including tumors or cancers.
US10238696B2 Lactic acid bacteria and use thereof
Lactic acid bacteria, which are isolated Lactococcus lactis subsp. lactis LL358 and isolated Lactobacillus salivarius LS159 respectively. By administering a composition comprising the lactic acid bacteria of the invention, renal injury, metabolic syndrome, hyperuricemia, hypocalcemia, and other disorders can be effectively ameliorated or treated.
US10238695B2 Use of microorganisms for reducing the level of trimethylamine in a human body cavity, in particular for the treatment of trimethylaminuria or of bacterial vaginosis and the prevention of cardiovascular diseases
Composition containing a microorganism, preferably an Archaea, expressing a TMA methyltransferase and a TMA methyl group acceptor corrinoid protein, capable of metabolizing trimethylamine (TMA) in the presence of hydrogen in a human cavity, such as the intestine or the vagina, for use as a medicament for treating, reducing or eliminating TMA at the level of the human cavity. In addition, a composition containing a TMA methyltransferase and a TMA methyl group acceptor corrinoid protein. These compositions are of use for treating trimethylaminuria, for treating vaginal fluids in the case of bacterial vaginosis and for reducing or eliminating odours due to TMA. These compositions are also of use for reducing the level of plasma TMAO, for preventing the formation of atheroma plaques and/or for preventing cardiovascular diseases.
US10238691B1 Peptides and scaffolds for use in immunotherapy against head and neck squamous cell carcinoma and other cancers
The present invention relates to peptides, proteins, nucleic acids and cells for use in immunotherapeutic methods. In particular, the present invention relates to the immunotherapy of cancer. The present invention furthermore relates to tumor-associated T-cell peptide epitopes, alone or in combination with other tumor-associated peptides that can for example serve as active pharmaceutical ingredients of vaccine compositions that stimulate anti-tumor immune responses, or to stimulate T cells ex vivo and transfer into patients. Peptides bound to molecules of the major histocompatibility complex (MHC), or peptides as such, can also be targets of antibodies, soluble T-cell receptors, and other binding molecules.
US10238687B2 Method for preparing a liposomal rehydration salt formulation
A liposomal rehydration salt formulation comprising phosphatidylcholine liposomes, salts, water, and a percentage inclusion ratio of salts (salts retained within said liposomes/total salts) of at least 40%; and a process for preparing said formulation using tangential ultrafiltration.
US10238685B2 Compositions containing polymeric sulfur and uses thereof
This invention relates to personal care compositions and methods of treating topical skin conditions using compositions containing polymeric sulfur Sn. The compositions of this invention may also preferably contain —SH-containing compounds such as thiols.
US10238683B2 Methods for promoting entry of an agent into a cell
A method for promoting entry of an agent (introduced agent) into a cell, the method comprising the step of complexing the introduced agent in the presence of an entry-promoting agent and then exposing to cells, wherein the entry-promoting agent comprises a linear and/or branched or cyclic polymonoguanide/polyguanidine, polybiguanide, analogue or derivative thereof according to the following Formula 1a & b. The method also provides a means for formation of nanoparticles formed between the entry promoting agent and the introduced agent. wherein: “n”, refers to number of repeating units in the polymer, and n can vary from 2 to 1000, for example from 2 or 5 to 10, 20, 30, 40, 50, 60, 70, 80, 90, 100, 150, 200, 250, 300, 350, 400, 450, 500, 600, 700, 800 or 900; G1 and G2 independently represent a cationic group comprising biguanide or guanidine, wherein L1, and L2 are directly joined to a Nitrogen atom of the guanide; L1 and L2 are linking groups between the G1 and G2 cationic groups in the polymer and independently represent an aliphatic group containing C1-C40 carbon atoms, for example an alkyl group such as methylene, ethylene, propylene, C4, C5, C6, C7, C8, C9 or C10; C1-C10, -C20, -C30, -C40, -C50 -C60 -C70, -C80, -C90, -C-100, -C110, -C120, -C130 or -C140, alkyl; or a C1-C140 (for example C1, C2, C3, C4, C5, C6, C7, C8, C9 or C10; C1-C10, -C20, -C30, -C40, -C50 -C60, - C70, -C80, -C90, -C100, -C110, -C120, -C130o or -C140), cycloaliphatic, heterocyclic, aromatic, aryl, alkylaryl, arylalkyl, or oxyalkylene radical; or a polyalkylene radical optionally interrupted by one or more, preferably one, oxygen, nitrogen or sulphur atoms, functional groups or saturated or unsaturated cyclic moiety; N and G3 are optional end groups; X can be either present or absent; L3, L4 and X are linking groups between the G4 and G5 cationic groups in the polymer and independently represent an aliphatic group containing C1-C140 carbon atoms, for example an alkyl group such as methylene, ethylene, propylene, C4, C5, C6, C7, C8, C9 or C10; C1-C10, -C20, -C30, -C40, -C50 -C60, -C70, -C80, -C90, -C100, -C110, -C120, -C130 or -C140, alkyl; or L3 and L4 and X can independently be C1-C140 (for example C1, C2, C3, C4, C5, C6, C7, C8, C9 or C10; C1-C10, -C20, -C30, -C40, -C50 -C60, -C70, -C80, -C90, -C100, -C110, -C120, -C130 or -C140), cycloaliphatic, heterocyclic, aromatic, aryl, alkylaryl, arylalkyl, oxyalkylene radicals; or a polyalkylene radical optionally interrupted by one or more, preferably one, oxygen, nitrogen or sulphur atoms, functional groups as well as saturated or unsaturated cyclic moiety; “G4” and “G5” are cationic moieties and can be same or different, and at least one of them is a biguanidine moiety or carbamoylguanidine, and the other moiety may be biguanidine or carbamoylguanidine or amine; and cationic moieties G4 and G5 do not contain single guanidine groups. The entry-promoting agent may comprise homogeneous or heterogeneous mixture of one or more of agents arising from formula 1 a and b, for example polyhexamethylene biguanide (PHMB), polyhexamethylene monoguanide (PHMG), polyethylene biguanide (PEB), polytetramethylene biguanide (PTMB), polyethylene hexamethylene biguanide (PEHMB), polymethylene biguanides (PMB), poly(allylbiguanidnio-co-allylamine), poly(N-vinylbiguanide), polyallybiguanide.
US10238682B2 Structure and use of 5′ phosphate oligonucleotides
Oligonucleotides bearing free, uncapped 5′ phosphate group(s) are recognized by RIG-I, leading to the induction of type I IFN, IL-18 and IL-1β production. Bacterial RNA also induces type I IFN production. 5′ phosphate oligonucleotides and bacterial RNA can be used for inducing an anti-viral response or an anti-bacterial response, in particular, type I IFN and/or IL-18 and/or IL-1β production, in vitro and in vivo and for treating various disorders and diseases such as viral infections, bacterial infections, parasitic infections, tumors, allergies, autoimmune diseases, immunodeficiencies and immunosuppression. Single-stranded 5′ triphosphate RNA can be used for inducing an anti-viral response, an anti-bacterial response, or an anti-tumor response, in particular, type I IFN and/or IL-18 and/or IL-1β production, in a target cell-specific manner.
US10238680B2 D-amino acid phosphoramidate pronucleotides of halogeno pyrimidine compounds for liver disease
Provided herein are compounds, compositions, and methods for the treatment of viral infections, for example, Flaviviridae infections, including HCV infections. In certain embodiments, compounds and compositions of nucleoside derivatives are disclosed, which can be administered either alone or in combination with other anti-viral agents. In certain embodiments, the compounds are D-amino acid phosphoramidate halogeno pyrimidine nucleoside analog compounds which display remarkable efficacy and bioavailability for the treatment of, for example, HCV infection in a human. In certain embodiments, the compounds are of Formula I: or a pharmaceutically acceptable salt, solvate, stereoisomeric form, tautomeric form, or polymorphic form thereof, wherein: PD, X, R1, R2, RA, and RB are as described herein.
US10238679B2 Antitumor activity of multi-kinase inhibitors in colorectal cancer
A composition for use in the prevention and/or treatment of colorectal cancer in a patient, comprising:a) a compound of Formula (I), where R1, R2, and R3 are, each one and independently, hydrogen or a protector group, wherein said protector group may consist of an alkyl group, a cycloalkyl group, a heterocyclic cycloalkyl group, a hydroxyalkyl group, a halogenated alkyl group, an alkoxyalkyl group, an alkenyl group, an alkynyl group, an aryl group, a heterocyclic aryl group, an alkylaryl group, an ester group, a carbonate group, a carboxylic acid group, an aldehyde group, a ketone group, a urethane group, a silyl group, a sulfoxide group or a combination thereof; R5, R6, R7, R8, R9 and R10 are, each one and independently, hydrogen, hydroxyl or an —OR4 group, where R4 is a protector group according to the previous definition; and b) at least one chemotherapeutic agent.
US10238676B2 Application of ginsenoside RG3 in preparing medicine for preventing and/or treating dementia, and medicine for treating dementia
The present invention discloses an application of ginsenoside Rg3 in preparing a medicine or product for preventing and treating dementia, and a preparation method thereof, which belong to the fields of medicines and health care products, and its products comprise a topical preparation, oral preparation and injection of the ginsenoside Rg3; and the Rg3 medicine or formulating prepared Rg3 compound medicine is prepared by using a solubilizer, a transdermal agent, a reagent promoting the absorption by penetrating a blood-brain barrier and an extractive, achieving the effect that the medicine penetrates the blood-brain barrier, and is used for preventing and treating dementia.
US10238675B2 Methods for treating pulmonary non-tuberculous mycobacterial infections
Provided herein are methods for treating a pulmonary infection in a patient in need thereof for example, a nontuberculous mycobacterial pulmonary infection for at least one treatment cycle. The method comprises administering to the lungs of the patient a pharmaceutical composition comprising a liposomal complexed aminoglycoside comprising a lipid component comprising electrically neutral lipids and an aminoglycoside. Administration comprises aerosolizing the pharmaceutical composition to provide an aerosolized pharmaceutical composition comprising a mixture of free aminoglycoside and liposomal complexed aminoglycoside, and administering the aerosolized pharmaceutical composition via a nebulizer to the lungs of the patient. The methods provided herein result in a change from baseline on the semi-quantitative scale for mycobacterial culture for a treated patient, and/or NTM culture conversion to negative during or after the administration period.
US10238674B2 Bovine milk oligosaccharides
Oligosaccharides from bovine milk, whey and dairy products, and methods of producing bovine milk oligosaccharides are provided.
US10238671B2 Hydrosoluble hydroxybisphosphonic derivatives of doxorubicin
The invention relates to hydrosoluble hydroxybisphosphonic derivatives of doxorubicin of formula (I) and the pharmaceutically acceptable salts thereof. The invention also relates to the use of said compounds as a drug, especially in the treatment of a bone tumour. The invention further relates to the pharmaceutical compositions comprising such compounds, the methods for the synthesis thereof and synthesis intermediates.
US10238664B2 Compositions and methods for the repair of myelin
Described are oxysterols, pharmaceutical compositions including the oxysterols, and methods of using the oxysterols and compositions for treating diseases and/or disorders related to myelin injury, such as neonatal brain injury, traumatic brain injury, spinal cord injury, cerebral palsy, seizures, cognitive delay, multiple sclerosis, stroke, autism, leukodystrophy, schizophrenia and bipolar disorder.
US10238659B2 Fatty liver disease treatment using glucocorticoid and mineralocorticoid receptor antagonists
The present invention provides treatment of fatty liver disease using a class of pyrimidinedione cyclohexyl compounds.
US10238654B2 Benzamides-containing compounds and their use in the treatment of epilepsy
The present invention is directed to benzamide-containing compounds of formula I or pharmaceutically acceptable salts thereof which inhibit the P2X7 receptor, and their use in the treatment of epilepsy.
US10238653B2 Method of treating metabolic disorders and depression with dopamine receptor agonists
This invention relates to methods and formulations for treating metabolic disorders and depression. In some embodiments, the methods comprise administering a dopamine receptor agonist and an anti-depressant.
US10238650B2 Method of treating cancer associated with a RAS mutation
Disclosed herein are methods of treating a cancer characterized by expressing a mutant form of a RAS protein. Some embodiments relate to treatment of cancer by administering Plinabulin to a subject in need thereof.
US10238649B2 Use of masitinib for treatment of cancer in patient subpopulations identified using predictor factors
A method for treating patients afflicted with cancer, wherein the patients are treated with a compound including tyrosine kinase inhibitor, mast cell inhibitor or c-Kit inhibitor, in particular masitinib, optionally in combination with at least one antineoplastic agent. The tyrosine kinase inhibitor, mast cell inhibitor or c-Kit inhibitor, and the optional at least one antineoplastic agent, are administered in a dosage regimen that includes a therapeutically effective amount. Also described are methods for predicting therapeutic response to the treatment in a given patient and therefore identification of applicable patient subpopulations based upon these predictor factors; sometimes referred to as biomarkers. One method is based upon the clinical marker of pain intensity. Another method is based upon gene expression predictive biomarkers assessed via RNA expression in peripheral blood cell samples collected prior to treatment with the compound, which is also used for treating patients afflicted with pancreatic cancer.
US10238637B2 Modulators of the adenosine A3 receptors
Modulators of adenosin A3 receptors of formula (I): And procedure for preparing these compounds. Other objectives of the present invention are to provide pharmaceutical compositions comprising an effective amount of these compounds and the use of the compounds for manufacturing a medicament for the treatment of pathological conditions or diseases that can improve by modulation of the adenosine A3 receptor.
US10238636B2 Methods of treating liver disease
The present disclosure relates to a method of preventing and/or treating liver disease comprising administering an ASK1 inhibitor in combination with a FXR agonist, to a patient in need thereof.
US10238635B2 N-carbamoylated urethane for treating a neuroinflammatory disease
There is provided a composition for treating a neuroinflammatory disease comprising a N-carbamoylated urethane compound which has an effect of inhibiting the activity of microglia or astrocytes and the production of nitric oxide (NO) and TNF-α, and suppressing the expression of IL-1β And iNOS genes. There is also provide a method for treating a neuroinflammatory disease, the method comprising the step of administering a N-carbamoylated urethane compound. Due to its above mentioned effects, the N-carbamoylated urethane compound according to the present invention can be useful for the treatment of neuroinflammatory diseases.
US10238630B2 Use of eribulin and poly (ADP ribose) polymerase (PARP) inhibitors as combination therapy for the treatment of cancer
The invention features methods for treating cancer in a patient in need thereof by administering eribulin, in combination with one or more PARP inhibitors, and, optionally, a platinum-based antineoplastic drug, and kits therefor. The invention is based in part on the observation that combinations of eribulin mesylate, a PARP inhibitor (e.g., E7449), and, optionally, a platinum-based antineo-plastic drug (e.g., carboplatin), show improved (e.g., synergistic) antitumor effects. Therefore, the present invention features methods of preventing and treating cancer (e.g., homologous recombination (HR)-deficient cancer by the use of combinations of eribulin (e.g., eribulin mesylate) and one or more PARP inhibitors (e.g., E7449 or a pharmaceutically acceptable salt thereof (e.g., the tartrate salt), optionally in combination with a platinum-based antineoplastic drug (e.g., carboplatin).
US10238628B2 Mast cell stabilizers treatment for systemic disorders
Methods for the treatment of systemic disorders treatable with mast cell stabilizers, including mast cell related disorders, are provided.
US10238626B2 Therapeutic compounds
The invention provides compounds of formula I: and salts thereof, as well as pharmaceutical compositions comprising such compounds. The compounds are useful for treating cancers, Alzheimer's disease, and conditions associated with demyelination.
US10238621B2 9,10-α,α-OH-taxane analogs and methods for production thereof
Provided herein are compounds, compositions containing the compounds, and methods for the treatment of cancer in a cancer patient. In particular, the compounds are made by a process comprising treating a first compound represented by either Formula G′ or Formula M′: with a second compound of generalized formula R8R9C(OCH3)2 and an acid selected from the group consisting of camphor sulfonic acid (CSA), p-toluene sulfonic acid (PTSA), hydrochloric acid (HCl) and acetic acid (AcOH), wherein R1 and R2 are each selected from H, an alkyl group, an olefinic group, an aromatic group, an O-alkyl group, an O-olefinic group, or an O-aromatic group; R7 is an alkyl group, an olefinic group, or an aromatic group; P1 is a hydroxyl protecting group; P5 is H or an acid labile protecting group at the 7-O position; R8 is H, alkyl group, olefinic or aromatic group; and R9 is: H, alkyl group, olefinic or aromatic or is as defined in the specification.
US10238618B2 Compositions and methods for diagnosis and treatment of anemia
Compositions including a fatty acid, such as an odd chain fatty acid or a very long even chain fatty acid, and salts and derivatives thereof, and methods for treatment and prophylaxis of conditions related to anemic conditions, are provided, including compositions and methods for treating anemic conditions such as hemolytic anemia and anemia of chronic disease, and other related conditions.
US10238617B2 Amino acid compositions and methods for the treatment of liver diseases
This disclosure provides pharmaceutical compositions comprising amino acid entities and uses thereof. Methods for improving liver function and for treating liver diseases comprising administering an effective amount of the compositions to a subject in need thereof are also disclosed.
US10238616B2 Immunomodulator
An immunomodulator useful for modulating immune function and maintaining intravital homeostasis is provided. The immunomodulator comprises S-1-propenycysteine or a salt thereof as an active ingredient.
US10238614B2 Uses of 6-aminohexanoic acid to manage bleeding conditions
This disclosure relates to the use of EACA (6-aminohexanoic acid) as an antifibrinolytic for the prevention of thrombocytopenic bleeds. In certain embodiment, the disclosure relates to methods of preventing bleeding in patients with thrombocytopenia resulting from hematological malignancies by administering 6-aminohexanoic acid, salts, or prodrugs thereof prophylactically to a subject in need thereof. In certain embodiments, subjects with stable chronic thrombocytopenia previously managed with platelet transfusion represent a selected group of patients that benefit from prophylaxis.
US10238612B2 Transdermal administration of tamsulosin
In an aspect of the invention, a composition for making a patch for the transdermal delivery of tamsulosin is provided. The composition comprises (a) at least about 1 wt % tamsulosin or a pharmaceutically acceptable salt of tamsulosin, (b) at least about 40 wt % polyisobutylene adhesive or hydrophobic synthetic rubber adhesive, (c) about 1-20 wt % of an aprotic solvent in which tamsulosin dissolves readily, (d) about 1-20 wt % of an unsaturated fatty acid or an alpha-hydroxy acid or a mixture of unsaturated fatty acids or alpha-hydroxy acids or of both unsaturated fatty acids and alpha-hydroxy acids, (e) a lipophilic permeation enhancer, and (f) a matrix modifier.
US10238608B2 Drug delivery product for controlled drug delivery
Present invention provides fully or partially biodegradable drug delivery product for controlled delivery of drugs. In one embodiment, the present invention relates to a drug delivery product having a shell comprising a first material and a second material, wherein the second material comprises a first biodegradable material; a core comprising a drug, the core being enclosed by the shell; wherein the first material is distributed in a matrix of the first biodegradable material; wherein the first material is configured to create holes in the shell; wherein the holes allow the drug to be released to the exterior of the shell through the holes.
US10238606B2 Pharmaceutical compositions for the treatment of Helicobacter pylori
Single oral solid dosage form comprising an immediate release first dosage composition having at least two antibiotic agents and a delayed release second dosage composition having a proton pump inhibitor are provided herein. The single oral solid dosage form according to some aspects of the invention can be used for the treatment of disorders associated with infection by H. pylori or the prevention of recurrence of disorders associated with infection by H. pylori.
US10238605B2 Dry coated tablet
Provided is a dry coated tablet showing high stability of the active ingredient (proton pump inhibitor, acetylsalicylic acid), which stably and rapidly expresses the pharmacological effect of the active ingredient after administration. A dry coated tablet having an inner core and an outer layer, wherein the inner core is an enteric-coated tablet containing acetylsalicylic acid, and the outer layer contains enteric micro granules containing a proton pump inhibitor.