最新美国发明专利第2019-02-12期 - 专利汇|PatentHub专利检索|专利查询网|发明专利查询分析

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US10202646B2	Digital counting of individual molecules by stochastic attachment of diverse labels Compositions, methods and kits are disclosed for high-sensitivity single molecule digital counting by the stochastic labeling of a collection of identical molecules by attachment of a diverse set of labels. Each copy of a molecule randomly chooses from a non-depleting reservoir of diverse labels. Detection may be by a variety of methods including hybridization based or sequencing. Molecules that would otherwise be identical in information content can be labeled to create a separately detectable product that is unique or approximately unique in a collection. This stochastic transformation relaxes the problem of counting molecules from one of locating and identifying identical molecules to a series of binary digital questions detecting whether preprogrammed labels are present. The methods may be used, for example, to estimate the number of separate molecules of a given type or types within a sample.
US10202641B2	Error correction in amplification of samples Disclosed herein are methods and systems for correcting errors in sample amplification, including the errors occurred in determining the number of targets in samples. In some embodiments, the method comprises: stochastically barcoding a plurality of targets in the samples using oligonucleotides comprising stochastic barcodes to generate stochastically barcoded targets; contacting one or more defined barcoded primers with each of the one or more samples; and determining an amplification noise.
US10202640B2	Single cell analysis of T cells using high-throughput multiplex amplification and deep sequencing Methods and oligonucleotide reagents for analyzing individual T cells are disclosed. In particular, the present disclosure provides methods for analyzing individual T cells using high-throughput multiplex amplification and deep sequencing of nucleic acids encoding T cell receptors (TCRs) and various other T cell phenotypic markers. The present disclosure further provides methods of reconstituting TCRs from individual T cells for functional studies, ligand discovery, or screening therapeutics.
US10202637B2	Methods for analyzing nucleic acid The invention generally relates to methods for analyzing nucleic acids. In certain aspects, methods of the invention involve obtaining a sample including a nucleic acid template. A plurality of molecular inversion probes are tiled across a portion of the template. The probes are designed such that immediately adjacent probes hybridize to opposite strands of the nucleic acid template and probes on the same strand hybridize to the template in an overlapping manner. A region between targeting arms of a plurality of the molecular inversion probes is filled-in with nucleotides, and the filled-in region of a plurality of the probes is analyzed to obtain sequence information about the nucleic acid template.
US10202630B2	Temperature shift for high yield expression of polypeptides in yeast and other transformed cells Methods for producing heterologous proteins are disclosed. In particular, the present disclosure provides improved methods of producing desired proteins, including multi-subunit proteins such as antibodies, with a higher yield and improved purity. In exemplary embodiments, the transformed cells are a yeast, e.g., methylotrophic yeast such as Pichia pastoris.
US10202629B2	Methods for amplification of nucleic acids utilizing clamp oligonucleotides The present invention provides methods of amplifying a target nucleic acid utilizing a clamp oligonucleotide comprising a first target-binding region on the 3′-terminus and a second target-binding region on the 5′-terminus and tether region in between. The tether region may comprise a variety of user-defined sequences or elements that allow for further manipulation of the target nucleic acid. Such as, for example, capture followed by amplification, identification and/or sequencing. The target-binding regions bind to the target nucleic acid, the 3′-terminus functions as a primer to initiate extension across the target nucleic acid sequence and ligation of the gap results in formation of a circularized nucleic acid. This circular template can be used in a variety of processes, including amplification and sequencing.
US10202628B2	Assembly of nucleic acid sequences in emulsions Methods and compositions for synthesizing nucleic acid sequences in an emulsion are provided.
US10202627B2	Method for producing trehangelin An object of the present invention is to provide enzymes and a DNA encoding the enzymes that are involved in biosynthesis of trehangelin which has the potential to be a therapeutic agent for photosensitivity disorder and cosmetics, and to provide a method for producing trehangelin by utilizing the enzymes and a recombinant microorganism. The present invention is directed to a protein having an amino acid sequence of SEQ ID NO: 3, 5, 7 or 9, or a protein having an amino acid sequence of SEQ ID NO: 3, 5, 7 or 9 in which one to several amino acids are deleted, substituted, added and/or inserted or an amino acid sequence having 60% or more homology with the amino acid sequence of SEQ ID NO: 3, 5, 7 or 9 and having an enzyme activity involved in biosynthesis of trehangelin; and a DNA encoding said protein.
US10202626B2	Compositions and methods for producing benzylisoquinoline alkaloids The present invention relates to host cells that produce compounds that are characterized as benzylisoquinolines, as well as select precursors and intermediates thereof. The host cells comprise one, two or more heterologous coding sequences wherein each of the heterologous coding sequences encodes an enzyme involved in the metabolic pathway of a benzylisoquinoline, or its precursors or intermediates from a starting compound. The invention also relates to methods of producing the benzylisoquinoline, as well as select precursors and intermediates thereof by culturing the host cells under culture conditions that promote expression of the enzymes that produce the benzylisoquinoline or precursors or intermediates thereof.
US10202624B2	Biosynthetic pathways and products This disclosure describes biosynthesized compounds including anhydromevalonolactone and β-methyl-δ-valerolactone. This disclosure further describes biosynthetic methods for making these compounds. In some embodiments, the biosynthetic methods can include a combination of biosynthesis and chemical steps to produce β-methyl-δ-valerolactone. Finally, this disclosure described recombinant cells useful for the biosynthesis of these compounds.
US10202617B2	Expression cassette for efficient surface display of antigenic proteins An expression cassette, wherein said expression cassette comprises: (a) an ie 1 promoter from white spot syndrome virus or a variant thereof; (b) a nucleic acid sequence encoding an N-terminal gp64 signal peptide or variant thereof, a nucleic acid sequence encoding an antigenic peptide, a nucleic acid encoding a transmembrane region, and a nucleic acid encoding a gp64 cytoplasmic region or variant thereof; in which the promoter is operably linked to the nucleic acid sequence.
US10202614B2	Digestibility of plant biomass Plants described herein have increased biomass and are more readily digested into fermentable sugars when the plants express increased levels of one or more types of CGR2 and/or CGR3 enzymes.
US10202609B2	Microorganisms producing L-amino acids and process for producing L-amino acids using the same Disclosed are a recombinant microorganism having enhanced L-amino acid producibility, wherein the recombinant microorganism is transformed to have an inactivated phage receptor thereof, and a method of producing an L-amino acid using the recombinant microorganism. The use of the recombinant microorganism may enable the production of the L-amino acid in a highly efficient manner.
US10202606B2	Complex containing oligonucleotide having immunopotentiating activity and use thereof The present invention provides an oligodeoxynucleotide containing humanized K type CpG oligodeoxynucleotide and poly deoxyadenylate, wherein the poly deoxyadenylate is placed on the 3′-side of the humanized K type CpG oligodeoxynucleotide. In addition, the present invention provides a complex containing the aforementioned oligodeoxynucleotide and β-1,3-glucan.
US10202602B2	Oligonucleotide analogues having modified intersubunit linkages and/or terminal groups Oligonucleotide analogs comprising modified intersubunit linkages and/or modified 3′ and/or 5′-end groups are provided. The disclosed compounds are useful for the treatment of diseases where inhibition of protein expression or correction of aberrant mRNA splice products produces beneficial therapeutic effects.
US10202601B2	C/EBPα short activating RNA compositions and methods of use The invention relates to saRNA targeting a C/EBPα transcript and therapeutic compositions comprising said saRNA. Methods of using the therapeutic compositions are also provided.
US10202600B2	AAV-based treatment of cholesterol-related disorders The invention in some aspects relates to methods and compositions for assessing the effectiveness of miRNA inhibitors. In other aspects of the invention, methods and compositions for treating cholesterol related disorders are provided. In one aspect of the invention, miRNA inhibitors against miR-122 and rAAV-based compositions comprising the same are provided.
US10202592B2	Polypeptides having xylanase activity and polynucleotides encoding same The present invention relates to isolated polypeptides having xylanase activity and isolated polynucleotides encoding the polypeptides. The invention also relates to nucleic acid constructs, vectors, and host cells comprising the polynucleotides as well as methods of producing and using the polypeptides.
US10202591B2	Methods and compositions for treatment of glycogen storage diseases and glycogen metabolism disorders The present disclosure provides for compositions comprising a chimeric polypeptide comprising a polypeptide effective for treating glycogen storage disease and an internalizing moiety that promotes delivery into cells. In certain embodiments, the polypeptide effective for treating glycogen storage disease is an acid alpha-glucosidase (GAA), a laforin, an amyloglucosidase (AGL), a malin, or an alpha amylase. The present disclosure also provides for methods for decreasing glycogen accumulation in cells or for treating glycogen storage diseases, including Forbes-Cori Disease, Andersen Disease, von Gierke Disease, Pompe Disease, and Lafora Disease, comprising administering the chimeric polypeptide disclosed herein.
US10202585B2	Modification of enzymatic crosslinkers for controlling properties of crosslinked matrices Improved matrix or hydrogel that is formed by enzymatic crosslinking of polymers wherein the crosslinking enzyme molecules have been modified for the purpose of improving the crosslinking density, mechanical properties, or other properties of the matrix, and/or to provide improved control over the rate and/or extent of crosslinking, wherein the enzyme molecules are modified to alter the perceived volume of the enzyme molecules in the crosslinked matrix being formed. Methods of production and of use are also provided.
US10202582B2	Duck enteritis virus and the uses thereof The present invention relates to DEV and the uses thereof. The invention is particularly suited to vaccinate poultry against avian pathogens.
US10202581B2	Methods and compositions for production of vaccinia virus Certain embodiments are directed to viral production processes for the large scale production of vaccinia virus.
US10202573B2	Apparatus for accelerating reproduction of odor from air-conditioner and method for the same The present invention relates to an apparatus and a method that can accelerate reproduction of odor from an air-conditioner by segmenting microorganisms, a temperature/humidity condition and nutrients for metabolism of the microorganisms as conditions for reproducing the odor from the air-conditioner and setting the segmented microorganisms, a temperature/humidity condition and nutrients for metabolism of the microorganisms according to an accelerated condition thereof.
US10202572B2	Culture container, culture observation apparatus and culture observation method A culture container includes a first transparent member being capable of keeping a predetermined temperature; a second transparent member facing to the first transparent member; a housing member to which the first transparent member and the second transparent member are adhered forming a culture space being capable of housing a well plate together with the first transparent member and the second transparent member; and a sealing member for sealing a liquid injected into the culture space between the first transparent member and the housing member.
US10202569B2	Radial microfluidic devices and methods of use A microfluidic device for simulating a function or response of a tissue is disclosed. The device includes an inlet for receiving a fluid in the device, and an outlet for removing the fluid from the device. The device further includes a fluid channel in fluid communication with the inlet and the outlet for flowing the fluid through the device. The fluid channel defines a chamber well that receives cells associated with the tissue. The device also includes an interface structure between the fluid channel and the chamber well for permitting migration of at least one of cells, particulates, chemicals, molecules, liquids, or gases between the fluid within the fluid channel and the chamber well.
US10202568B2	Automated cell culture system and method An automated method for culturing stem cells using a robotic liquid handling system including a translatable bed and a movable multichannel pipette. The method includes the steps of: locating a first multi-well cell culture plate and a multi-trough plate on the bed; placing a suspension of stem cells in at least one trough of the multi-trough plate; using the multi-channel pipette, transferring a portion of the suspension of stem cells to each well of the first multi-well cell culture plate such that at least two of the wells of the first multi-well cell culture plate have different densities of stem cells; selecting a well of the first multi-well cell culture plate having a desired stem cell density; locating a second multi-well cell culture plate; and using the multi-channel pipette, transferring the cells of the selected well to a plurality of wells of the second multi-well cell culture plate.
US10202565B2	Container for fabric treatment composition A container for a fabric treatment composition having: (a) a container floor extending to a floor boundary; (b) a sump adjacent to at least a portion of the container floor, wherein a portion of the container floor adjacent the sump has a container floor elevation head, wherein the sump has a sump elevation head less than the container floor elevation head adjacent the sump, at least a portion of the sump being located on a longitudinal axis of the container; (c) a peripheral wall extending from the container floor; and (e) a needle piercable membrane operatively engaged with the peripheral wall to define an interior volume, wherein the interior volume contains between about 10 mL and about 100 mL a liquid fabric treatment composition.
US10202563B2	Cleaning fluid and cleaning method A cleaning fluid for cleaning a site to which ink adheres in an inkjet printer which ejects aqueous inkjet ink containing a pigment and alkali-soluble resin having an acid group in a molecule, wherein the cleaning fluid contains an amphoteric surfactant, a basic compound, and water, a pH range of the cleaning fluid is from 9 to 12, the amphoteric surfactant is at least one selected from a group consisting of dimethyl lauryl amine oxide, lauryl dimethyl amino acetic acid betaine and a 2-al-kyl-n-carboxymethyl-n-hydroxyethyl imidazolinium betaine and is contained in an amount of 0.1 to 3% by mass to the total amount of the cleaning fluid.
US10202562B2	Membrane-based processes for selectively fractionating essential oils The present disclosure in general relates to a process for (1) reducing impurities, i.e. undesirable natural components such as waxes and undesirable synthetic materials such as agrochemicals and other environmental pollutants, or (2) fractionation of natural components present in an essential oil using at least one selective membrane.
US10202561B2	Lubricating compositions for motor vehicles Disclosed are lubricating compositions and base oils for motor vehicles, specifically for engines, gearboxes, or vehicle axle assemblies. The lubricating composition contains an oil-soluble polymer that is a specific polyalkyl glycol or a specific polyalkylene glycol (PAG). Also described is use of the lubricating composition for reducing fuel consumption in a vehicle provided with an engine, an axle assembly, or a gearbox that are lubricated using the lubricating composition or the specific PAG.
US10202557B2	Methods of producing calcined coke from bio-oil and calcined coke produced thereby Disclosed are methods of producing calcined coke from bio-oil from a biomass feedstock. Also disclosed are calcined cokes produced by such methods.
US10202554B2	Process and plant for the recovery and utilization of higher olefins in the olefin synthesis from oxygenates A process and a plant for producing olefins from oxygenates such as methanol and/or dimethyl ether are proposed, in which initially the oxygenates are converted to a primary product containing propylene, other olefins, paraffins and aromatics in an olefin synthesis reactor. The primary product is separated into hydrocarbon fractions of different C chain length, wherein short-chain olefins such as propylene are obtained and beside further fractions there is also obtained a C7− fraction which contains C5/C6 olefins, as well as a C7+ fraction which contains aromatics. From the latter, the aromatics are separated and alkylated with the C5/C6 olefins to obtain alkyl aromatics. The same are hydrogenated completely and recirculated to the olefin synthesis reactor, where they likewise are converted to short-chain olefins.
US10202553B2	Hydroprocessing catalyst for heavy hydrocarbon oil, method for manufacturing hydroprocessing catalyst for heavy hydrocarbon oil, and hydroprocessing method for heavy hydrocarbon oil The hydroprocessing catalyst for a heavy hydrocarbon oil, includes, as a carrier, a phosphorus-silica-containing alumina carrier containing 0.1% by mass to 4% by mass of phosphorus in terms of oxide based on the carrier, and 0.1% by mass to 1.5% by mass of silica based on the carrier, the carrier supporting 8% by mass to 20% by mass of at least one selected from metals in Group 6 of the periodic table in terms of oxide based on the catalyst and 2% by mass to 6% by mass of at least one selected from metals in Groups 8 to 10 of the periodic table in terms of oxide based on the catalyst.
US10202551B2	Dewatering compositions and methods The present invention is drawn to dewatering components and methods for their use. As particularly preferred, the invention relates to dewatering components comprising a cationic starch and/or a tannin capable of separating and/or resolving oil-in-water emulsions, water-in-oil emulsions, particularly in crude petroleum oil.
US10202542B2	Aqueous slurry for particulates transportation An aqueous slurry composition for use in industries such as petroleum and pipeline industries comprises an aqueous liquid, particulates, a hydrophobizing agent that renders the particulate surface hydrophobic and a hydrophobic polymer. The slurry is produced by rendering the surface of the particulate hydrophobic during or prior to making the slurry. The method and composition can find many applications in different industries, particularly in petroleum industry.
US10202538B2	Method for inhibiting structure II gas hydrate formation The present invention provides a method for inhibiting structure II (sII) gas hydrate formation which comprises treating (i) a gas hydrate inhibitor and (ii) at least one additive selected from the group consisting of N-hexyl-N-methyl-pyrrolidinium tetrafluoroborate (HMP-BF4), M-hydroxyethyl-N-methyl-pyrrolidinium tetrafluoroborate (HEMP-BF4), N-ethyl-N-methyl-immidazolium tetrafluoroborate (EMIM-BF4) and N-ethyl-N-methyl-pyrrolidinium tetrafluoroborate (EMP-BF4) in water, which is in contact with a gas mixture of forming structure II gas hydrate.The additives according to the present invention can exhibit the same or greater effects of inhibiting the formation of the structure II gas hydrate through an interaction, even when the amount of a gas hydrate inhibitor is reduced.
US10202528B2	Polymer and composition including same, and adhesive composition There is provided a novel polymer, a composition containing the polymer, and a novel adhesive composition containing the polymer from which a cured film having desired properties is obtained. A polymer comprising a structural unit of Formula (1): wherein Q is a bivalent group, R1 is a C1-10 alkylene group, a C2-10 alkenylene group or C2-10 alkynylene group, a C6-14 arylene group, a C4-10 cyclic alkylene group, etc., or a polymer comprising a structural unit of Formula (6): wherein Q4 is an allyl group, a vinyl group, an epoxy group, or a glycidyl group, and R5 is a bivalent organic group having a main chain containing only carbon atom or at least one of oxygen atom, nitrogen atom and sulfur atom in addition to carbon atom, a composition comprising the polymer, and an adhesive composition comprising the polymer and a solvent.
US10202527B2	Primer-less two component polyurethane adhesive A process of applying an adhesive to an elastomer includes the application to the elastomer of a two part adhesive formulation. The adhesive having a Part A including at least a polyol, an adhesion promoter, a chain extender, a catalyst, a water scavenger; and a Part B comprising: polyurethane prepolymer, adhesion promoter and a plasticizer. The two part adhesive formulation is cured to form the adhesive. In contrast to the prior art, no priming or surface activation is required to obtain a high strength bond to the elastomer. The resulting article of an elastomer with the resultant adhesive is sufficiently strong to result in surface peel off of the elastomer. A kit is provided for the repair of an elastomer without resort to priming the elastomer.
US10202526B2	Adhesive composition and adhesive film for touch panel Provided are: an adhesive composition for a touch panel, including an acrylic resin, a first curing agent having one to three functional groups, a second curing agent having four to six functional groups, and an ultraviolet blocking agent containing a benzotriazole group; and an adhesive film for a touch panel, including a cured product of the composition.
US10202525B2	Pressure sensitive adhesive composition, pressure sensitive adhesive film, and method of manufacturing organic electronic device using the same Provided are a pressure-sensitive adhesive composition, a pressure-sensitive adhesive film, and a method of manufacturing an organic electronic device using the same. The pressure-sensitive adhesive composition that may effectively prevent moisture or oxygen added to an organic electronic device from an external environment, and exhibit reliability under harsh conditions such as high temperature and high humidity and excellent optical characteristics, and a pressure-sensitive adhesive film including the same are provided.
US10202523B2	Ice adhesion reducing prepolymers and polymers The present disclosure relates to an FPOSS prepolymer which may be reacted with a reactive coating or a polyisocyanate and/or one or more of a polysiloxane, a polyol, a polyamine and a reactive coating; an FPOSS polyisocyanate prepolymer which may be reacted with one or more of a polysiloxane, a polyol, a polyamine or a reactive coating; and an FPOSS siloxane prepolymer which may be reacted with a polyisocyanate and/or one or more of a polyol, a polyamine or a reactive coating to form cross-linked polymers capable of reducing the ability of ice to adhere to the surface of an object, in particular aircraft or other vehicles, methods of producing the prepolymers and polymers and their use in coating surfaces.
US10202521B2	Dish support rack for dishwasher The invention pertains to a dish support rack having outstanding resistance to chemically harsh environments, and possessing improved mechanical properties, said dish support rack comprising a metal wire frame coated with a polyamide composition [composition (C)] comprising: —more than 50% wt of a polyamide [polyamide (A), herein after], more than 50% moles of recurring units of said polyamide complying with formula: —HN—(CH2)6—NH—C(O)—(CH2)8—C(O)— [recurring units (R6,10)], and, optionally: —up to 10% wt of conventional filler(s) and/or additive(s), and to a method for its manufacture.
US10202519B2	Inkjet adhesive, manufacturing method for semiconductor device, and electronic component Provided is an inkjet adhesive which is applied using an inkjet device, wherein the adhesive can suppress generation of voids in the adhesive layer and, after bonding, can enhance adhesiveness, moisture-resistant adhesion reliability, and cooling/heating cycle reliability. An inkjet adhesive according to the present invention comprises a photocurable compound, a photo-radical initiator, a thermosetting compound having one or more cyclic ether groups or cyclic thioether groups, and a compound capable of reacting with the thermosetting compound, and the compound capable of reacting with the thermosetting compound contains aromatic amine.
US10202515B2	Water-based ink for ink-jet recording and ink cartridge A water-based ink for ink-jet recording includes: a pigment; water; polyoxypropylene methyl glucoside; and a compound represented by the formula (1): in the formula (1), R is a straight or branched chain alkyl group having 2 to 10 carbon atoms.
US10202511B2	Hydrophilic coating film, method for producing same, humidification element, and humidification device To provide a hydrophilic coating film that excels not only in initial humidification performance, but also in long-term humidification performance as well as to provide a production method for the hydrophilic coating film, and a humidification element. A hydrophilic coating film (7) contains porous silica gel particles (3), fine inorganic particles (2) having an average particle diameter smaller than an average pore diameter of the silica gel particles (3), and a thickener (8). A production method for the hydrophilic coating film (7) coats a base material (1) with a coating composition and dries the coated base material (1), the coating composition containing water (6), a thickener (6), porous silica gel particles (3), and fine inorganic particles (2) having an average particle diameter smaller than an average pore diameter of the silica gel particles (3).
US10202508B2	Dye compounds Mixtures containing at least one dye compound having a diketopyrrolopyrrole structure and at least one further liquid-crystalline compound are suitable for use in devices for regulating the entry of light into a space.
US10202505B2	Polypropylene and articles thereof The invention relates to a process for the preparation of polypropylene having: a molecular weight of 450,000-950,000, a molecular weight distribution of 3-6, and xylene soluble content of 2-6 wt %, by converting propylene into the polypropylene without pre-polymerization in the presence of a polymerization catalyst under a condition where the volume ratio of H2 to propylene is at most 0.0020, wherein the catalyst comprises a catalyst component and a co-catalyst, wherein the catalyst component is obtained by a process wherein a compound with formula Mg(OAlk)xCly wherein x is larger than 0 and smaller than 2, y equals 2−x and each Alk, independently, represents an alkyl group, is contacted with a titanium tetraalkoxide and/or an alcohol in the presence of an inert dispersant to give an intermediate reaction product and wherein the intermediate reaction product is contacted with titanium tetrachloride in the presence of an internal donor.
US10202503B2	Rubber composition for base tread Provided is a rubber composition for base tread which can improve steering stability, rolling resistance and durability without deteriorating extrusion processability, comprising 1.8 to 3.5 parts by mass of sulfur and 36 to 60 parts by mass of filler for reinforcement comprising not less than 7 parts by mass of silica based on 100 parts by mass of a rubber component comprising:(a) not less than 0% by mass and not more than 20% by mass of (a1) a polybutadiene rubber comprising 2.5 to 20% by mass of 1,2-syndiotactic polybutadiene crystal and/or (a2) a butadiene rubber synthesized with a rare earth containing catalyst; (b) more than 5% by mass and not more than 60% by mass of (b1) a predetermined tin-modified polybutadiene rubber and/or (b2) a modified butadiene rubber modified with a predetermined compound; and (c) 40 to 75% by mass of a diene rubber other than (a) and (b).
US10202502B2	Method for producing antimicrobial polyester fiber yarn containing volcanic ash The present invention relates to a method for producing an antimicrobial polyester fiber yarn containing volcanic ash, the method comprising the steps of: crushing and heating volcanic ash, and allowing the heated volcanic ash to collide under an air stream in an air classifier mill system to obtain volcanic ash powder; subjecting the volcanic ash powder to nano-milling to obtain nano-sized volcanic ash particles; disintegrating the volcanic ash particles to prepare nano volcanic ash; mixing the prepared nano volcanic ash with polyester for fiber use at a weight ratio of 10:90-30:70, followed by melt extrusion, thereby preparing a highly dispersed volcanic ash master batch; and mixing the volcanic ash master batch with polyester for fiber use at a weight ratio of 4:96-8:92, followed by spinning to produce an antimicrobial polyester fiber yarn.
US10202496B2	Polyvinylidene fluoride resin particles and method for producing same A production method of polyvinylidene fluoride resin particles comprising: (Process a1) a process to precipitate the polyvinylidene fluoride resin particles by adding a 100 mass % solution in total consisting of 75 to 99 mass % organic solvent, 1 to 25 mass % water and 0.5 to 15 mass % polyvinylidene fluoride resin to a poor solvent of the polyvinylidene fluoride resin; or (Process a2) a process to precipitate polyvinylidene fluoride resin particles by performing a flash-crystallization of the solution. With such a configuration, PVDF resin particles can be industrially produced by simple operations without using surfactant agent.
US10202494B2	Block copolymers having amine or phosphine functionalized end blocks Disclosed herein is a functionalized block copolymer comprising (a) at least one end block D comprising on average at least one amino- or phosphino-functionalized polymer unit of formula (I) and one or more additional blocks selected from the group consisting of (b) one or more A blocks substantially free of amino- or phosphino- functional groups and having a number average molecular weight of from about 1,000 to about 60,000, and has a high service temperature, and (c) one or more B blocks, wherein each block B is essentially non-functionalized, has a number average molecular weight of from about 1,000 to about 1,000,000, and has a glass transition temperature of at most about 20° C., and (d) mixtures of one or more A blocks and one or more B blocks; wherein Z is nitrogen or phosphorus; R1 is hydrogen or alkyl; R2 is hydrogen or is tertiary alkyl; R each independently, is alkyl or phenyl optionally substituted by a moiety -(A1-NRa)xRb or -(A1-ORa)xRb; or two R groups, together with the Z to which they are bonded, form an optionally substituted ring; x is 1, 2 or 3; A1 is straight chain alkylene optionally substituted by one or more methyl and/or ethyl groups; and Ra and Rb, each independently, is hydrogen or alkyl; or a corresponding onium salt.
US10202492B2	Polyetherimide sulfone compositions, method of manufacture, and articles prepared therefrom A thermoplastic composition is described herein including a first polyetherimide sulfone having a glass transition temperature of 250 to 290° C., and a second polyetherimide sulfone having a glass transition temperature of 230 to 249° C. The composition has an advantageous combination of optical properties including improved yellowness index, transmission, and haze. A method of manufacturing the thermoplastic composition and articles including the thermoplastic composition are also described. A method for improving the optical properties of a thermoplastic composition is also disclosed, where the method includes melt mixing the first and second polyetherimide sulfones, each having a glass transition temperature as defined herein. The method provides a composition having at least one of improved yellowness, haze, and transmission.
US10202490B2	Biocompatible polymers for medical devices The present invention relates to new classes of monomeric compounds, which may be polymerized to form novel biodegradable and bioresorble polymers and copolymers. These polymers and co-polymers, while not limited thereto, may be adapted for radio-opacity and are useful for medical device applications and controlled release therapeutic formulations.
US10202488B2	Isocyanate-free synthesis of carbonate-modified polymers The present invention relates to an isocyanate-free and preferably solvent-free process for preparing polymers containing five-membered cyclic carbonate groups. In particular, the present invention is directed to a process for preparing polymers bearing cyclic carbonate groups by reacting carboxyl-bearing polymers selected from the group including polyesters based on di- or polyols and di- or polycarboxylic acids or derivatives thereof or poly(meth)acrylates, with hydroxyl-functionalized five-membered cyclic carbonates, without addition of isocyanates.
US10202485B2	Polymerizable composition for optical material, optical material, and method of manufacturing optical material The polymerizable composition for an optical material of the present invention includes: (A) a compound having a carbon-carbon triple bond and at least one group selected from an isocyanate group and an isothiocyanate group in a molecule; and (B) a polythiol compound.
US10202480B2	Block copolymer The present application provides the block copolymers and their application. The block copolymer has an excellent self assembling property and phase separation and various required functions can be freely applied thereto as necessary.
US10202477B2	Optically clear hot melt processable high refractive index adhesives Adhesive compositions that are optically transparent include a (meth)acrylate-based copolymer having a refractive index of at least 1.48, and particles of a thermoplastic polymer. At least some of the particles have an average particle size that is larger than the wavelength of visible light. The adhesive compositions are prepared by hot melt processing packaged adhesive compositions.
US10202476B2	Polybutene preparation method A method for preparing polybutene includes the steps of: supplying a C4 mixture to an isomerization reactor in which (i) 1-butene is isomerized into 2-butene by a hydrogen isomerization reaction using an isomerization catalyst in an isomerization zone of the isomerization reactor and (ii) iso-butene and 2-butene are separated by fractional distillation in a fractional distillation zone; supplying a C4 mixture containing 2-butene which is separated in the isomerization reactor to a skeletal isomerization reactor, in which a part of normal-butene is skeletal isomerized into iso-butene by a skeletal isomerization reaction using a skeletal isomerization catalyst, and the obtained skeletal isomerization mixture is supplied and recycled to the isomerization reactor; and supplying (i) a raw material containing the iso-butene of high concentration and which is separated from the isomerization reactor and (ii) a polymerization catalyst to a polybutene polymerization reactor and thereby producing polybutene by a polymerization reaction.
US10202473B2	Hydrophilic polymeric particles and methods for making and using same A method of forming a particle includes, in a disperse phase within an aqueous suspension, polymerizing a plurality of mer units of a hydrophilic monomer having a hydrophobic protection group, thereby forming a polymeric particle including a plurality of the hydrophobic protection groups. The method further includes converting the polymeric particle to a hydrophilic particle.
US10202472B1	Olefin polymerization process A process for the preparation of an ethylene polymer including the step of polymerizing ethylene or copolymerizing ethylene and one or more other olefins in the presence of a Phillips-type chromium catalyst in a gas-phase polymerization reactor containing a reactor bed of particulate polymer, wherein the gas-phase polymerization reactor is equipped with a cycle gas line, wherein the reactor gas returned to the polymerization reactor through the cycle gas line has been condensed in part and the amount of liquid in the returned reactor gas is from 0.5 wt. % to 10 wt. % based upon the total weight of the reactor gas/liquid composition, the polymerization is carried out at from 108° C. to 125° C., and an aluminum alkyl is fed into the polymerization reactor in an amount in the range of from 0.0025 mole to 0.1 mole per ton of dosed ethylene.
US10202470B2	Polymerizable composition and optically anisotropic body using same The present invention provides a polymerizable composition containing a specific polymerizable compound and a fluorosurfactant having a specific polyoxyalkylene skeleton and having specific molecular weight. The invention also provides an optically anisotropic body, a retardation film, an antireflective film, and a liquid crystal display device that are produced using the polymerizable composition of the present invention. The present invention is useful because, when an optically anisotropic body is produced by photo-polymerization of the polymerizable composition, three features including the leveling properties of the surface of the optically anisotropic body, offset onto the substrate, and liquid crystal alignment can be improved simultaneously.
US10202466B2	Linked peptide fluorogenic biosensors Biosensors, compositions comprising biosensors, methods of producing biosensors, and methods of using biosensors are disclosed. The biosensors comprise a fluorogen-activating peptide and a blocking peptide. The fluorogen-activating peptide and blocking peptide are covalently linked through a peptide linker. The blocking peptide associates with the fluorogen-activating peptide thereby blocking an active domain of the fluorogen-activating peptide when the linker is in an unmodified state. The peptide linker may contain an amino acid sequence that is specifically recognized as a modification substrate by a cognate enzyme. The fluorogen-activating peptide and the blocking peptide at least partially disassociate when the linker is modified by an enzyme, thereby allowing the fluorogen-activating peptide to bind a cognate fluorogen and modulate a fluorescence signal.
US10202457B2	Anti-DEspR monoclonal antibody targeted therapy and imaging for cancer and stroke Provided herein are novel compositions comprising anti-DEspR antibodies and fragments thereof derived from 6G8G7 and 7C5B2 anti-DEspR variant antibodies, including fully human, composite engineered human, humanized, monoclonal, and polyclonal anti-DEspR antibodies and fragments thereof, and methods of their use in a variety of therapeutic applications. The compositions comprising the anti-DEspR antibodies and fragments thereof described herein are useful in diagnostic and imaging methods, such as DEspR-targeted molecular imaging of angiogenesis, and for companion diagnostic and/or in vivo non-invasive imaging and/or assessments.
US10202455B2	Molecular constructs with targeting and effector moieties comprising an SCFV specific for ectodomain of transferrin-1 receptor and fingolimod The present disclosure provides various molecular constructs having a targeting element and an effector element. Methods for treating various diseases using such molecular constructs are also disclosed.
US10202452B2	CD3 binding polypeptides The present invention relates to mono-specific and multi-specific polypeptides that specifically bind or interact with CD3. These polypeptides can be, but are not limited to, antibodies, fragments thereof, scFvs, Fabs, di-scFvs single domain antibodies, diabodies, dual variable domain binding proteins and polypeptides containing an antibody or antibody fragments. In one embodiment, a multi-specific polypeptide binds both a T-cell receptor complex on T-cells and a tumor antigen to induce target-dependent T-cell cytotoxicity, activation and proliferation.
US10202448B2	Anti-IL-23 antibodies The present invention relates to anti-IL-23p19 binding compounds, in particular new humanized anti-IL-23p19 antibodies and therapeutic and diagnostic methods and compositions for using the same.
US10202446B2	Anti FGF23 antibody and a pharmaceutical composition comprising the same To provide an antibody against FGF23 and a pharmaceutical composition such as a preventive or therapeutic agent which can prevent or treat by suppressing an action of FGF23 by using the antibody. An antibody or its functional fragment against human FGF23 produced by hybridoma C10 (Accession No. FERM BP-10772).
US10202443B2	TDP-43-binding polypeptides useful for the treatment of neurodegenerative diseases Provided herein are antigen-binding constructs such as antibodies that bind to the RRM-1 domain of TDP-43. The antigen-binding constructs are capable of blocking the interaction of TDP-43 with NF-κB in cells. Also provided herein are method of using the antigen-binding constructs in the treatment of diseases associated with TPD-43 proteinopathy, such as amyotrophic lateral sclerosis (ALS), frontotemperal lobar degeneration (FTLD), Lewy body disease and motor neuron disease.
US10202438B2	Synthetic library of specific binding molecules The present invention provides methods for the production of a library of antigen specific antigen binding molecules having a peptide domain structure represented by the following formula (I): FW 1-CDR1-FW2-HV2-FW3a-HV4-FW3b-CDR3-FW4 comprising (1) isolating RNA from a member of a species in the Elasmobranchii subclass; (2) amplifying DNA sequences from RNA obtained; (3) selecting a DNA sequence from the database prepared; (4) amplifying DNA sequences encoding two or more contiguous peptide domains of FW1-CDR1-FW2-HV2-FW3a-HV4-FW3b-CDR3-FW4; (5) ligating together said amplified DNA sequences to form DNA sequences encoding an antigen specific binding molecule; (6) cloning the amplified DNA obtained into a display vector; and (7) transforming a host with said display vector to produce a library of said antigen specific antigen binding molecules. The invention also provides methods for the production of an antigen specific antigen binding molecule as defined, pharmaceutical compositions comprising such molecules and uses thereof in medicine.
US10202434B2	Fusion proteins of collagen-binding domain and parathyroid hormone Fusion proteins containing active agonist or antagonist fragments of parathyroid hormone (PTH) and parathyroid hormone related peptide (PTHrP) coupled to a collagen-binding domain are presented. The fusion proteins can be used to promote bone growth, to promote hair growth, to prevent cancer metastasis to bone, to promote immune reconstitution with a bone marrow stem cell transplant, to promote mobilization of bone marrow stem cells for collection for autologous stem cell transplant, and to treat renal osteodystrophy. Pharmaceutical agents comprising a collagen-binding polypeptide segment linked to a non-peptidyl PTH/PTHrP receptor agonist or antagonist are also presented.
US10202429B2	Norrin regulation of cellular production of junction proteins and use to treat retinal vasculature edema A method of tightening inter-cellular junctions in retinal or choroidal vessel cells includes exposing the retinal or choroidal vessel cells to norrin. Upon sufficient contact time, for norrin to selectively up-regulate gene expression of VE-cadherin or claudin-5 in the retinal or choroidal vessel cells, the inter-cellular junctions are tightened. The method is also suitable for treating retinal pigment epithelial cells in wet macular degeneration.
US10202428B2	Compositions and methods for the delivery of oxygen H—NOX proteins are mutated to exhibit improved or optimal kinetic and thermodynamic properties for blood gas O2 delivery. The engineered H—NOX proteins comprise mutations that impart altered O2 or NO ligand-binding relative to the corresponding wild-type H—NOX domain, and are operative as physiologically compatible mammalian blood O2 gas carriers. The invention also provides pharmaceutical compositions, kits, and methods that use wild-type or mutant H—NOX proteins for the treatment of any condition for which delivery of O2 is beneficial.
US10202423B2	Picornavirus-like particle production in plants A method of producing a picornavirus-like particle (PVLP) in a plant is provided. The method comprises introducing a first nucleic acid and a second nucleic acid into the plant, portion of the plant, or a plant cell. The first nucleic acid comprising a first regulatory region active in the plant operatively linked to a nucleotide sequence encoding a polyprotein. The second nucleic acid comprises a second regulatory region active in the plant and operatively linked to a nucleotide sequence encoding one or more protease. The plant, portion of the plant, or plant cell is incubated under conditions that permit the expression of the nucleic acids, thereby producing the PVLP. A PVLP comprising the polyprotein is also provided.
US10202420B2	Methods and compositions for treatment of cartilage and disc tissue pathologies An isolated polypeptide comprising a peptide selected from: i) DHX1SDNYT, wherein X1 is L or H (SEQ ID NO:3); ii) a conservative variant of i) iii) a fragment of i) or ii); wherein the conservative variant and/or fragment retains biological activity and the peptide is 15 or less amino acids as well as recombinant cells, and uses thereof.
US10202419B2	Connective tissue stimulating peptides Novel peptides are described which comprise an amino acid motif selected from the group consisting of “PG”, “GP”, “PI” and “IG” and having up to 10 amino acids upstream and/or downstream of the amino acid motif, wherein “P” in the motif is proline or hydroxyproline and the peptide stimulates the development, maintenance and repair of bone, cartilage and associated connective tissue. The invention further relates to pharmaceutical compositions of these peptides, as well as therapeutic and prophylactic uses of such peptides.
US10202416B2	Purification method for divalent cation binding proteins on anion exchange resin The present invention relates to a method for the purification of divalent cation binding proteins with high purity on an anion exchange resin material, to divalent cation binding proteins obtainable by said method, and to a kit comprising means for carrying out said method.
US10202409B2	1, 1′ -bis(phosphino)ferrocene ligands for alkoxycarbonylation Compound of formula (I) where R2, R4 are each independently selected from —(C1-C12)-alkyl, —(C3-C12)-cycloalkyl, —(C3-C12)-heterocycloalkyl, —(C6-C20)-aryl; the R1, R3 radicals are each a —(C3-C20)-heteroaryl radical; R1, R3 may each independently be substituted by one or more substituents selected from —(C1-C12)-alkyl, —(C3-C12)-cycloalkyl, —(C3-C12)-heterocycloalkyl, —O—(C1-C12)-alkyl, —O—(C1-C12)-alkyl-(C6-C20)-aryl, —O—(C3-C12)-cycloalkyl, —S—(C1-C12)-alkyl, —S—(C3-C12)-cycloalkyl, —COO—(C1-C12)-alkyl, —COO—(C3-C12)-cycloalkyl, —CONH—(C1-C12)-alkyl, —CONH—(C3-C12)-cycloalkyl, —CO—(C1-C12)-alkyl, —CO—(C3-C12)-cycloalkyl, —N—[(C1-C12)-alkyl]2, —(C6-C20)-aryl, —(C6-C20)-aryl-(C1-C12)-alkyl, —(C6-C20)-aryl-O—(C1-C12)-alkyl, —(C3-C20)-heteroaryl, —(C3-C20)-heteroaryl-(C1-C12)-alkyl, —(C3-C20)-heteroaryl-O—(C1-C12)-alkyl, —COOH, —OH, —SO3H, —NH2, halogen; R2, R4, if they are —(C1-C12)-alkyl, —(C3-C12)-cycloalkyl, —(C3-C12)-heterocycloalkyl or —(C6-C20)-aryl, may each independently be substituted by one or more substituents selected from —(C1-C12)-alkyl, —(C3-C12)-cycloalkyl, —(C3-C12)-heterocycloalkyl, —O—(C1-C12)-alkyl, —O—(C1-C12)-alkyl-(C6-C20)-aryl, —O—(C3-C12)-cycloalkyl, —S—(C1-C12)-alkyl, —S—(C3-C12)-cycloalkyl, —COO—(C1-C12)-alkyl, —COO—(C3-C12)-cycloalkyl, —CONH—(C1-C12)-alkyl, —CONH—(C3-C12)-cycloalkyl, —CO—(C1-C12)-alkyl, —CO—(C3-C12)-cycloalkyl, —N—[(C1-C12)-alkyl]2, —(C6-C20)-aryl, —(C6-C20)-aryl-(C1-C12)-alkyl, —(C6-C20)-aryl-O—(C1-C12)-alkyl, —(C3-C20)-heteroaryl, —(C3-C20)-heteroaryl-(C1-C12)-alkyl, —(C3-C20)-heteroaryl-O—(C1-C12)-alkyl, —COOH, —OH, —SO3H, —NH2, halogen. The invention also relates to Pd complexes of the compound according to the invention, and to the use thereof in an alkoxycarbonylation process.
US10202407B2	Trisilyl amine derivative, method for preparing the same and silicon-containing thin film using the same Provided are a novel trisilyl amine derivative, a method for preparing the same, and a silicon-containing thin film using the same, wherein the trisilyl amine derivative, which is a compound having thermal stability, high volatility, and high reactivity and being present in a liquid state at room temperature and under pressure where handling is possible, may form a high purity silicon-containing thin film having excellent physical and electrical properties by various deposition methods.
US10202405B2	Fused pentacyclic imidazole derivatives A series of fused pentacyclic imidazole derivatives, being potent modulators of human TNFa activity, are accordingly of benefit in the treatment and/or prevention of various human ailments, including autoimmune and inflammatory disorders; neurological and neurodegenerative disorders; pain and nociceptive disorders; cardiovascular disorders; metabolic disorders; ocular disorders; and oncological disorders. In particular, the present invention is concerned with 6,7-dihydro-7,14-methanobenzimidazo[1,2-b][2,5]benzodiazocin-5(14H)-one derivatives and analogs thereof.
US10202402B2	Purification of rapamycin derivatives using temperature induced phase separation The present invention provides methods for obtaining purified rapamycin derivatives, including purified Biolimus A9. A crystalline form of Biolimus A9 is also described.
US10202401B2	Process for making tetracyclic heterocycle compounds The present invention is directed to a process for making Tetracyclic Heterocycle Compounds of Formula (I): and pharmaceutically acceptable salts thereof, wherein X1, X2, R1, R2 and R3 are defined above herein. The present invention is also directed to compounds that may be useful as synthetic intermediates in the process of the invention.
US10202397B2	Anti-cancer compounds targeting Ral GTPases and methods of using the same Methods of inhibiting the growth or metastasis of a cancer in a subject by inhibiting a Ral GTPase in the subject, and small molecule inhibitors of Ral GTPases useful in the methods of the invention. Pharmaceutical compositions containing the compounds of the invention, and methods of using the same.
US10202395B2	Macrocycle with repeating triazole-carbazole units Disclosed herein are compositions of tricarbazole triazolophane (tricarb) of Formulas (I), (II) and (III): wherein R of Formula (I) is selected from a group consisting of alkyl (for example, C6-C18), alkyl-substituted phenyl derivatives, and substituted glycol derivatives, among others, or a combination thereof, and R, R′ and R″ of Formulas (II) and (III) are independently selected from a group consisting of alkyl (for example, C6 to C18), alkyl-substituted phenyl derivatives, and substituted glycol derivatives, or a combination thereof. The disclosure presents examples of thin films composed of the same as well as methods of binding anions from the same.
US10202391B2	Chemical compounds The present disclosure concerns compounds of Formula (I) or pharmaceutically-acceptable salts thereof, wherein R1, R2 and R3 have any of the meanings defined hereinbefore in the description; processes for their preparation, pharmaceutical compositions containing them and their use in the treatment of cancer.
US10202389B2	Pyrazolopyrimidinyl inhibitors of ubiquitin-activating enzyme Disclosed are chemical entities that inhibit ubiquitin-activating enzyme (UAE), each of which is a compound of Formula I: or a pharmaceutically acceptable salt thereof, wherein Y is and W, Z, XY, RY1, RY2 and RY3 are defined herein; pharmaceutical compositions comprising the chemical entities; and methods of using the chemical entities. These chemical entities are useful for treating disorders, particularly cell proliferation disorders, including cancers.
US10202388B2	Fused-ring compounds, pharmaceutical composition and uses thereof This disclosure is related to a fused-ring compound of formula (I) and/or a pharmaceutically acceptable salt thereof, a pharmaceutical composition comprising the fused ring compound of formula (I) and/or a pharmaceutically acceptable salt thereof, preparation methods thereof, and use thereof in modulating activity of indoleamine 2, 3-dioxygenase (IDO) and/or tryptophan 2, 3-dioxygenase (TDO). This disclosure further provides methods of treating IDO and/or TDO-associated diseases, including cancer, viral infection and autoimmune diseases.
US10202386B2	Pyrrolo[3,2-D]pyrimidine derivatives as inducers of human interferon Compounds of formula (I) and salts thereof: wherein R1 is hydrogen, methyl or —(CH2)2OR3, R2 is methyl or —(CH2)2OR4, or R1 and R2, together with the nitrogen atom to which they are attached, are linked to form a 5- or 6-membered heterocyclyl wherein the 6-membered heterocyclyl is optionally substituted by two hydroxy substituents; R3 and R4 are each independently hydrogen or methyl; and n is an integer having a value of 5 or 6, are inducers of human interferon. Compounds which induce human interferon may be useful in the treatment or prevention of various disorders, for example the treatment or prevention of allergic diseases and other inflammatory conditions, for example allergic rhinitis and asthma, infectious diseases and cancer, and may also be useful as vaccine adjuvants.
US10202381B2	Histone demethylase inhibitors The present invention relates generally to compositions and methods for treating cancer and neoplastic disease. Provided herein are substituted pyrido[3,4-d]pyrimidin-4-one derivative compounds and pharmaceutical compositions comprising said compounds. The subject compounds and compositions are useful for inhibition of histone demethylase. Furthermore, the subject compounds and compositions are useful for the treatment of cancer, such as prostate cancer, breast cancer, bladder cancer, lung cancer, melanoma, and the like.
US10202378B2	Therapeutic compounds and uses thereof The present invention relates to compounds of formula (I): and to salts thereof, wherein R1-R6 have any of the values defined in the specification, and compositions and uses thereof. The compounds are useful as inhibitors of TAF1. Also included are pharmaceutical compositions comprising a compound of formula (I) or a pharmaceutically acceptable salt thereof, and methods of using such compounds and salts in the treatment of various TAF1-mediated disorders.
US10202374B2	6-aryl-4-phenylamino-quinazoline analogs as phosphoinositide-3-kinase inhibitors The present invention relates to 6-aryl-4-phenylamino quinazolines of formula I wherein, R and R′ are as herein described. The present invention particularly relates to synthesis and anticancer and phoshpoinositide-3-kinase-α (PI3K-α) inhibitory activity. In addition, the invention relates to methods of using compounds for treating or preventing various cancers such as pancreatic, prostate, breast and melanoma.
US10202370B2	Benzimidazole derivatives as selective proteine kinase inhibitors Disclosed are compounds of formula I or pharmaceutically acceptable salts thereof: Wherein n, R1, R2, R3, R4, R5, A, Q and X are as defined in the description. These compounds selectively modulate, regulate, and/or inhibit signal transduction mediated by certain native and/or mutant protein kinases implicated in a variety of human and animal diseases such as cell proliferative, metabolic, allergic, and degenerative disorders. More particularly, these compounds are potent and selective native and/or mutant c-kit inhibitors.
US10202369B2	1,3-thiazol-2-yl substituted benzamides The present invention relates to 1,3-thiazol-2-yl substituted benzamide compounds of general formula (I) as described and defined herein, to pharmaceutical compositions and combinations comprising said compounds and to the use of said compounds for manufacturing a pharmaceutical composition for the treatment or prophylaxis of a disease, in particular of neurogenic disorder, as a sole agent or in combination with other active ingredients.
US10202367B2	Heterocyclic compounds and methods of use thereof Disclosed are compounds of formula (I), formula (II), and formula (III): wherein Ar, R1, A, and X are as defined in the specification. These compounds are antiviral agents and are contemplated for use in the treatment of viral infections, for example, hepatitis C. These compounds are also contemplated for use in treating or preventing cancers.
US10202365B2	2-(pyridin-3-yl)-pyrimidine derivatives as RET inhibitors Described herein are compounds, such as compounds of Formula (I) and pharmaceutically acceptable salts thereof, that inhibit wild-type RET and its resistant mutants, pharmaceutical compositions including such compounds, and methods of using such compounds and compositions, e.g., for treating a condition mediated by aberrant RET activity
US10202363B2	Compounds, compositions and methods The disclosed subject matter provides certain polymorphic forms of Compound (I) as well as pharmaceutical compositions comprising Compound (I) or such polymorphic forms, and methods of using or making such compounds and pharmaceutical compositions. It has now been discovered that Compound (I) can exist in multiple crystalline forms (polymorphs). One particular crystalline form, Form II, has been found to be more thermodynamically stable and, thus, likely more suitable for bulk preparation and handling than other polymorphic forms. Efficient and economic methods have been developed to prepare Compound (I) and Form II in high purity on a large scale. In animal studies, Form II has demonstrated safety and efficacy in treating depressive disorders and, when micronized, improved absorption compared to non-micronized Form II.
US10202360B2	Therapeutic compounds The present disclosure relates to substituted heterocyclic derivative therapeutic compounds, compositions comprising said compounds, and the use of said compounds and compositions for epigenetic regulation by inhibition of bromodomain-mediated recognition of acetyl lysine regions of proteins, such as histones. Said compositions and methods are useful for the treatment of diseases mediated by aberrant cell signalling, such as inflammatory disorders, cancer and neoplastic disease.
US10202357B2	Class of quinolone heterocyclic aromatic molecules for cancer treatment The invention is directed to new class of quinolone heterocyclic aromatic molecules (Renotinibs) and their use in the treatment of cancer, in particular, cancer that harbor abnormal human epidermal growth factor receptors (EGFRs).
US10202349B2	Asymmetric bis-acridines with antitumour activity and their uses We disclose novel asymmetric bis-acridines with antitumor activity. These compounds are useful for use in pharmaceuticals, particularly in the treatment or the prevention of neoplasms.
US10202348B2	Compositions and methods of treating retinal disease Compositions and methods for treating macular degeneration and other forms of retinal disease whose etiology involves the accumulation of A2E and/or lipofuscin, and, more specifically, for preventing the formation and/or accumulation of A2E are disclosed.
US10202346B2	Phenol derivatives and the pharmaceutical or cosmetic use thereof The use of compounds in the treatment of skin disorders is described. In particular, use of a compound of formula (I): or one of its pharmaceutically acceptable salts, solvates or hydrates in the preparation of a medicament to treat skin pathologies is described.
US10202345B2	Substituted azaspiro(4.5)decane derivatives The invention relates to substituted spirocyclic cyclohexane derivatives which have an affinity for the μ opioid receptor and the ORL1 receptor, processes for the preparation thereof, medicaments containing these compounds and the use of these compounds for the preparation of medicaments.
US10202343B2	MIF modulators The invention provides novel heterocyclic compounds, pharmaceutical compositions and methods of treatment that modulate levels of MIF expression and treat disorders associated with high or low levels of MIF expression.
US10202336B2	Plant for urea production Plant for the synthesis of urea, comprising: a synthesis section comprising at least one reactor, a compressor for supplying CO2 to said synthesis section, a gas turbine for the operation of said CO2 compressor and a heat recovery steam generator; the heat source of said heat recovery steam generator consists of the exhaust gases of said gas turbine, and at least one steam flow produced by said heat recovery steam generator is used as heat source for at least one component of said urea plant.
US10202333B2	Aqueous solution containing bis(N epsilon lauroyllysine)dicarboxylic acid diamide and/or salt thereof, and method for producing same The present invention provides a method of producing an aqueous solution containing bis(Nε-lauroyl lysine)dicarboxylic acid diamide and/or a salt thereof, and having a pH of 9-11, which includes a first step of reacting Nε-lauroyl lysine and/or a salt thereof with dicarboxylic acid dichloride in a water solvent having a pH of 12-14 to form bis(Nε-lauroyl lysine)dicarboxylic acid diamide and/or a salt thereof, a second step of adjusting the aqueous solution obtained in the first step to pH 7.5-8.5, a third step of adding Nε-lauroyl lysine to the aqueous solution obtained in the second step and filtering the mixture, and a fourth step of adjusting the aqueous solution obtained in the third step to pH 9-11.
US10202332B2	Method for preparing 2-amino-N-(2,2,2-trifluoroethyl) acetamide Disclosed are methods for preparing compounds of Formula 1 and 1A. The first method utilizes a benzyl carbamate amine protecting group and an intermediate of Formula 4. The second method utilizes a tert-butyl carbamate amine protecting group and an intermediate of Formula 7. The third method utilizes a dibenzyl amine protecting group. Also disclosed is a compound, phenylmethyl N-[2-oxo-2-[(2,2,2-trifluoroethyl)amino]ethyl]carbamate (a compound of Formula 4). Further disclosed is a method for preparing a compound of Formula 14 from a compound of Formula 15 and a compound of Formula 1 or 1A.
US10202323B2	Process for preparing an arylpropene A process for preparing an arylpropene from a diarylpropane by gas phase thermolysis in the presence of boron containing zeolitic material comprising a membered ring (MR) pore system greater than 10 MR.
US10202321B1	Method of simultaneously preparing 1,1,1-trifluoro-2-chloropropene and 1,1,1,2-tetrafluoropropene using gas phase catalyst Disclosed is a method of simultaneously preparing 1,1,1-trifluoro-2-chloropropene and 1,1,1,2-tetrafluoropropene, the method including i) a step of elevating a temperature of a reactor charged with a gas phase catalyst up to a reaction temperature; ii) a step of feeding 1,1,1-trifluoro-2,3-dichloropropane and 2-chloro-1,1,1,2-tetrafluoropropane into the reactor, the temperature of which has been elevated; iii) a step of performing dehydrochlorination while maintaining the temperature of the reactor; and iv) a step of performing washing and distillation after the dehydrochlorination. In accordance with the present disclosure, a high-efficient gas-phase process of continuously, simultaneously preparing 1,1,1-trifluoro-2-chloropropene and 1,1,1,2-tetrafluoropropene is provided.
US10202319B2	Process for olefin production by metathesis and reactor system therefor The present invention relates to a process for obtaining an olefin by metathesis including the steps of i) feeding at least one stream with at least one olefin as starting material to at least one first reactor with at least one pre-bed having at least one compound selected from the group of alkaline earth oxides and ii) feeding the stream leaving the at least one first reactor to at least one second reactor downstream to the at least one first reactor including at least one main bed having a) at least one first catalyst component and b) at least one second catalyst component. The first and second catalyst are physically mixed with each other. The operational temperature of the at least one first reactor is lower than the operational temperature of the at least one second reactor.
US10202316B2	3-(5-substituted-4-oxoquinazolin-3(4H)-yl)-3-deutero-piperidine-2,6-dione derivatives and compositions comprising and methods of using the same The invention provides 3-deuterium-enriched 3-(5-substituted-4-oxoquinazolin-3(4H)-yl)-piperidine-2,6-diones, deuterated derivatives thereof, stereoisomers thereof, pharmaceutically acceptable salt forms thereof, and methods of treatment using the same, such as in the treatment of cancer, an immune-related disease, or an inflammatory disease.
US10202308B2	Composite material, articles comprising same and method for making same Composite material comprising aluminum nitride (AlN) material, less than 80 weight percent cubic boron nitride (cBN) grains dispersed within the AlN material and less that 5 weight percent sinter promotion material, the composite material including no more than about 1.5 percent porosity.
US10202306B2	Method for coloring ceramics via colloidal dispersion In a method of coloring a ceramic material, a coloring solution consisting of metallic salts is introduced to a ceramic slurry. In a slip casting process, a coloring solution consisting of metallic salts is introduced to a ceramic slurry which is cast into green state bodies. A coloring solution that may comprise for example a metallic salt, a solvent, an organic solvent such as derivatives of propylene oxides, and an acid can be introduced to the slip casting process. Such a coloring solution can be added to the slip casting process. In a method, the coloring solution is thoroughly mixed with the ceramic slurry, after which a ceramic body is cast, dried and finally subjected to a sintering process. After final sinter, the resulting ceramic body possesses an innate color that is homogenous throughout its composition. The method is especially useful for coloring zirconia ceramic material used for making dental restorations.
US10202304B2	Component for low-temperature applications The present disclosure relates to a component for low-temperature applications, a process for producing such a component, and the use thereof.
US10202303B2	Compressively stressed laminated glass article via photosensitive glass and method of making the article Laminated articles comprised of glass core and clad layers, more specifically, to compressively stressed laminated articles comprising a glass core sandwiched between first and second clad layers, the clad layers being formed from photosensitive glass.
US10202301B2	Apparatus for manufacturing an optical fiber An apparatus for manufacturing an optical fiber including: a drawing portion; a coating portion; and a curing portion, wherein: a direction changer which changes a direction of the bare optical fiber is disposed in any position from the drawing portion to the coating portion; the direction changer includes a guide groove which guides the bare optical fiber; a blowout port of a fluid which floats the bare optical fiber wired along the guide groove is formed along the guide groove in the guide groove; and in the blowout port, the Reynolds number in an inlet wire portion of the bare optical fiber to the guide groove and an outlet wire portion from the guide groove is greater than the Reynolds number in an intermediate portion between the inlet wire portion and the outlet wire portion.
US10202300B2	Strengthened glass articles, edge-strengthened laminated glass articles, and methods for making the same A method of manufacturing a laminated glass article is disclosed that includes forming a laminated glass article with at least one glass cladding layer and a glass core layer adhered to the glass cladding layer. The glass core layer is amenable to crystallization and optionally has a viscosity amenable to forming by a fusion lamination method. The method further includes removing a portion of the laminated glass article such that the glass core layer is exposed on at least one edge of the laminated glass article, and crystallizing at least a portion of the exposed glass core layer. A crystallized or semi-crystallized surface of the exposed glass core layer has a lower CTE than a remainder of the glass core layer. A laminated glass article and a glass article having a crystalline or semi-crystalline surface portion that is integral with a bulk of the glass body are also disclosed.
US10202298B2	Polarizing glass plate and method for manufacturing same, polarizing glass plate set for optical isolator, and method for manufacturing optical element for optical isolator A method of manufacturing a polarizing glass sheet includes subjecting, while heating, a glass preform sheet containing metal halide particles to down-drawing, to thereby provide a glass member having stretched metal halide particles dispersed in an aligned manner in a glass matrix, and subjecting the glass member to reduction treatment to reduce the stretched metal halide particles, to thereby provide a polarizing glass sheet. A shape of the glass preform sheet during the down-drawing satisfies a relationship of the following expression: L1/W1≥1.0 where L1 represents a length between a portion in which a width of the glass preform sheet has changed to 0.8 times an original width and a portion in which the width of the glass preform sheet has changed to 0.2 times the original width W0, and W1 represents a length equivalent to 0.5 times the original width W0 of the glass preform sheet.
US10202297B2	Glass inlet tube environmental control A system and method are described herein for controlling an environment around an inlet tube in the glass manufacturing system. More specifically, the system and method control a level of hydrogen within a humid gas mixture that flows over an exterior of the inlet tube to effectively suppress the formation of undesirable gaseous inclusions in molten glass that flows through the inlet tube.
US10202296B2	Aeration device Aeration device includes a hollow casing having a motor therein; a mixing unit formed on front side of the casing and having a discharge hole formed in radial direction and an intake hole formed on front thereof; an impeller located inside the mixing unit and coupled to a driving shaft of the motor, the driving shaft extended to the mixing unit, so as to be rotated with the driving shaft, to generate flow in outward radial direction upon rotation, an air inflow unit having one side end located in front of the impeller and serving as an air inflow pipe for introducing air to the mixing unit; and an auxiliary intake unit located on front side of the impeller to be rotated with the driving shaft of the motor and inserted into the air inflow unit to allow fluid in the air inflow unit to flow backward upon rotation.
US10202292B2	System and method of water purification utilizing an ionomer membrane A water purification system utilizes an ionomer membrane and mild vacuum to draw water from source water through the membrane. A water source may be salt water or a contaminated water source. The water drawn through the membrane passes across the condenser chamber to a condenser surface where it is condensed into purified water. The condenser surface may be metal or any other suitable surface and may be flat or pleated. In addition, the condenser surface may be maintained at a lower temperature than the water on the water source side of the membrane. The ionomer membrane may be configured in a cartridge, a pleated or flat plate configuration. A latent heat loop may be configured to carry the latent heat of vaporization from the condenser back to the water source side of the ionomer membrane. The source water may be heated by a solar water heater.
US10202290B1	Oil skimmer An apparatus for removing oil or other pollutants from the surface of water, comprising a platform having a left side wall, a right side wall, a rear wall, a front opening, a floor, and a bottom, one or more ballasts which adjust the platform floor relative to a level of oil on the water surface, wherein the oil flows from the front opening across the floor to the rear wall, a rear location near the rear wall to collect the oil from the platform floor; and a pump connected to the rear location that removes the oil from the rear location to a storage area which does not affect the ballast of the platform. The skimmer vessel can work stationary in the water, and does not require a propeller means, as the oil will continue to flow into the skimmer as the oil is pumped out of the rear by the gravity flow to the rear of the vessel.
US10202289B1	Method and apparatus for treating production water Method and apparatus are provided for treating salt water. In the method, a feed water is run through a skimmer unit to form de-oiled water. The de-oiled water is passed through an electrocoagulation unit to form electrocoagulated water. A precipitating agent is added to the electrocoagulated water and stirred to form a water/floc mixture. A polymeric coagulation enhancing agent is added to the water/floc mixture with mild stirring and coagulants in the mixture are permitted to settle. A partly clarified water from the mixture is drawn out from a level above the settled coagulants. The partly clarified water is run through at least one settler and coagulants are removed from the bottom of the at least one settler. A clarified salt water stream is withdrawn from the final settler. The necessary equipment can be mounted on a trailer. The trailer can be provided with a stairway and catwalk to facilitate safe inspection.
US10202286B2	Method and system for treating wastewater Treating brine to produce distilled water and dried NaCl. The brine enters a crystallization plant and is heated. Once heated, the brine is circulated to an evaporator. The evaporator increases the concentration of NaCl in the brine to a point about the super saturation level. Once above the super saturation level, NaCl crystals are formed. The larger crystals are circulated to a centrifuge for drying and the smaller crystals are recirculated through the evaporator for continued growth. The NaCl crystals are dried in the centrifuge.
US10202285B1	Dual screen treatment system Vaults, boxes, systems, and methods of treatment systems to capture pollutants from storm water runoff and prevent the conveyance of these pollutants from entering a receiving water body or landscape area, which is designed to be a part of a local permanent storm water drainage infrastructure. A single treatment box, vault and system combines both drainage conveyance, multi-level treatment techniques, variable hydraulic capabilities, and easy and inexpensive methods for servicing the system. A flow spreader can split incoming water to pass into dual screen filtration systems. The system can include components selected from a shelf beneath the spreader, at least one baffle, skimmer, deflectors, media filtration and water pressure lines with spray heads for cleaning debris on a sloped floor.
US10202279B2	CaMg2-based alloy hydride material for hydrolysis production of hydrogen, preparation method therefor and use thereof Provided are a CaMg2-based alloy hydride material for hydrolysis production of hydrogen, a preparation method therefor and a use thereof. The material has a general formula of CaMgxMyHz, wherein M is Ni, Co or Fe, 1.5≤x<2.0, 0
US10202276B2	Method for manufacturing microcantilever Disclosed is a method for manufacturing a microcantilever having a predetermined thickness that includes forming a liquid synthetic resin for cantilevers to a thickness corresponding to the thickness of the microcantilever on an upper surface of a base block having an adhesive base and a non-adhesive base, and curing the liquid synthetic resin for cantilevers via a boundary between the adhesive base and the non-adhesive base, wherein the adhesive base has stronger adhesivity to the cured synthetic resin for cantilevers than the non-adhesive base.
US10202273B2	Electronic vaporiser system An electronic cigarette vaporizer that includes a heating element and further includes or co-operates with an electronics module that (i) detects characteristics of the delivery of power, current or voltage to the heating element and (ii) determines if those characteristics are associated with degradation of the heating element. A characteristic that is associated with degradation of the heating element is an increase or other change in the heating element resistance. The heating element resistance can be established by the electronics module sending a test current through the heating element that is sufficient to enable a measurement of resistance to be made.
US10202272B2	Electronic vaporiser system The invention is an electronic cigarette vaporizer system operable in a ‘discrete’ mode to reduce the amount of vapor produced by a vaporizer that forms part of the system, compared to a normal mode. The ‘discrete’ mode causes the vapor produced to be less visible or noticeable, compared to a normal mode.
US10202271B2	Fuel verification system Fuel management systems for a fuel dispensing facility including a fuel delivery system are disclosed. The fuel delivery system includes at least one storage tank configured to contain a fuel, at least one dispenser configured to receive the fuel from the at least one storage tank, and a fuel handling system which is configured to one of (1) deliver the fuel to the at least one storage tank, (2) receive the fuel from the at least one storage tank, (3) monitor for a leak within the fuel delivery system, and (4) monitor for a fuel inventory within the fuel delivery system. The fuel management system may include installation records of the fuel handling components. The fuel management system may monitor cameras positioned in sumps of the fuel delivery system. The fuel delivery system may include a camera positioned to monitor an interior of a sump, the interior of the sump being provided by a sump basin and a sump cover. The sump cover may be a sump lid. The sump cover may be a dispenser. The sump cover may be another portion of the fuel delivery system.
US10202269B2	Beverage dispenser and method for sanitation thereof A method for sanitizing a beverage dispenser apparatus includes filling fluid in at least a hot beverage tank of a beverage dispensing apparatus, heating the fluid in the hot beverage tank to a predetermined temperature range, configuring the drain valve to a closed state, activating a primary sanitation cycle by causing the heated fluid from the hot beverage tank to flow through at least a first subset of components of the beverage dispenser apparatus and terminating the primary sanitation cycle when at least one predetermined condition is satisfied. A secondary sanitation cycle is activated by causing the heated fluid from the hot beverage tank to flow through at least a second subset of components of the beverage dispenser apparatus.
US10202266B2	Low profile compact tool carriers Compact tool carriers having a loader mounted to a low-profile mainframe are disclosed. In some embodiments, the pivot points of the mainframe about which the loader is pivoted are low relative to the mainframe to reduce the mainframe size and to lower the center of gravity to improve the stability of the compact tool carrier during use.
US10202265B2	Winch cable wiper assembly A winch is described comprising a rotatable drum for winding and unwinding a first cable therefrom. The winch contains a cable-wiping apparatus with one or more actuators are activated when the drum rotates in a direction for winding the first cable onto the drum. A mechanical force may be transmitted from the actuator to a second cable that is operatively connected to a wiper clamp. The wiper clamp compresses around the first cable when the cable is pulled in.
US10202262B2	Method of operating a crane, and crane A crane may include a travelable undercarriage, a superstructure rotatably supported thereon with a luffable boom system arranged thereon and a derrick boom, with an auxiliary crane being used as derrick ballast. In The auxiliary crane may be driven onto a ballast base plate attached to the derrick boom for the alignment of the boom system in order to thus form at least a large portion of the counter-weight.
US10202259B2	Vertical and horizontal movement system Vertical and horizontal movement system of one or more cabins (20) for the transport of people and things in a elevator shifter plant with portal structure (10) for the overcoming overhead and not, back and forth even automatic, obstacles such as roads, railways, waterways and other obstacles affected by driveways and not, especially for pedestrians, usable either in an overhead manner that underground and also incorporated in large buildings such as hospitals, airports, railway stations and so on, with two or more runaways running horizontally and vertically, in which one or more runways include vertical and horizontal stops and descents placed at different levels to overcome obstacles also passing under the same; operated by rack, wherein the motor is rigidly coupled to the cabin and acts via a pinion gear on the rack, having inclined toothing, to increase the fluidity of the movement reducing vibration and noise.
US10202258B2	Method for determining state of elevator system component A method determines a status of at least one component of an elevator system, wherein the elevator system includes a suspension apparatus having at least one traction member. The at least one traction member is surrounded by a non-metallic cladding, wherein the suspension apparatus is guided via a drive sheave with a metallic traction surface. The method includes the steps of: identifying at least one parameter based on an electrostatic effect which occurs due to friction of the non-metallic cladding on the traction sheave with the metallic traction surface; and determining a status of the at least one component on the basis of the identified parameter.
US10202254B2	Method for extracting a thread by suction from a bobbin and a corresponding system A system and associated operational method are provided to extract a thread by suction from a bobbin and for re-attachment of a thread end of the thread to a new thread. The thread is extracted from the bobbin by sucking the thread in against its spooling direction on the bobbin through a suction nozzle and into an extraction port of an extraction system. A loop is subsequently formed in the thread, and the thread is separated in the area of the loop. One thread end of the separated thread is discharged into an extraction port, and the other thread end coming from the bobbin is prepared for re-attachment to a new thread. Upon being extracted by suction into the extraction system, the thread is guided through an eyelet located in a run of the thread to the extraction port and the eyelet, together with the thread, is moved out of the run of the thread to the extraction port such that the thread forms the loop between the bobbin, the eyelet, and the extraction port.
US10202240B2	Storage system In one arrangement, a storage system for storing items includes an enclosure enclosing a hypoxic environment, and a pallet shuttle system comprising rows of racks disposed within the hypoxic environment. The pallet shuttle system also includes at least one transfer car and at least one shuttle for carrying storage modules into and out of the racks. The system further includes a loading station outside the hypoxic environment, and an enclosure door to the hypoxic environment. The enclosure door is operable to admit the transfer car of the pallet shuttle system into and out of the hypoxic environment, and to close the hypoxic environment upon passage of the transfer car through the door. Optionally, the system includes paneling separating the enclosure into at least two separately climate-controlled zones such that at least one of the racks is in each of the at least two separately climate-controlled zones.
US10202235B2	Disposable sealant liquid canister for an inflatable article repair and relative production method A disposable canister filled with sealant liquid has an inner closure for retaining the sealant liquid inside the canister; a compressed-air inlet conduit; an outlet conduit for receiving the sealant liquid when the closure is in an open position; a first portion having one of the inlet and outlet conduits; and a second portion; the first and second portions being joined by a weld to form a tank which holds the sealant liquid in a ready-for-use position by means of the closure.
US10202226B1	Lid with hidden stacking A kit of thermoformed lids comprising a three lids which are substantially similar except for specific differences in four stacking areas located at the corners of the lids. Unlike prior art lids that use convex external lugs to provide separation during stacking, lids according to the present invention have stacking areas formed as interruptions in concave channels located along the peripheries of the lids, improving the appearance and uniformity of products comprising the lids.
US10202224B2	Liquid dispensing nozzle and device comprising a cap A liquid dispensing nozzle having an opening, a removable cap, a residual liquid evaporation path between the opening and the exterior of the nozzle, an element for blocking the evaporation path, mobile in the cap between a blocking position and a position opening the evaporation path, the cap including an exterior envelope and an interior envelope that are coaxial, and mobile relative to one another in an axial direction between: a storage configuration; a configuration for unscrewing the cap when a bearing force exerted on the cap has an intensity greater than a predetermined threshold; a safety configuration if a bearing force exerted on the cap has an intensity lower than the predetermined threshold or if no bearing force is exerted on the cap, the blocking element being configured to be driven by the movement of the exterior envelope to pass from the blocking position to the opening position.
US10202220B2	Shipping container and divider for the same A divider for a shipping container is formed from a single sheet of material. The divider includes a front panel having a plurality of feet; a first platform panel attached to the front panel along a first fold line; at least one divider assembly, and a rear panel having a plurality of feet. Each divider assembly in turn includes a divider interconnector panel to interconnect the divider assembly to a preceding panel; a divider wall panel attached to the divider interconnector panel along an interconnector-wall fold line; and a divider platform panel attached to the divider wall panel along a wall-platform fold line. The at least one divider assembly is attached to the first platform panel along a first divider assembly fold line and to the rear panel along a final divider assembly fold line.
US10202219B1	Dual handle cooler box design, blank and methods Dual handle box designs, blanks for forming boxes by folding, collapsible and non-collapsible boxes formed thereby, and manufacturing methods therefor are disclosed. Preferably each handle is located on an opposite end of the box; is two-ply; defines an elongate hand opening for receiving fingers of a hand; defines an elongate tab opening for receiving a tab of a center handle, and that intersects the hand opening; and defines a recess for receiving and retaining a lid panel of the box. Furthermore, the boxes preferably have a waterproof or water-resistant coating applied and are used as ice coolers for beverages and food items.
US10202218B2	Delaminatable container Provided is a delamination container having improved oxygen barrier properties. The present invention provides a delamination container provided with a container body having an outer shell and an inner pouch, the inner pouch being adapted to delaminate from the outer shell and contract in association with a decrease of the contents, wherein the inner layer constituting the inner pouch is provided with, in order from the container outer surface side, an outside layer, an adhesive layer, and an inside layer. The outside layer includes an EVOH layer, and the inside layer has a thickness of 60-200 μm and a flexural modulus of 250 MPa or less, the value (thickness of the inside layer/thickness of the EVOH layer) being 1.1-5, and the total thickness of the inside layer being 100-250 μm.
US10202209B2	Launch vehicle and system and method for economically efficient launch thereof The present disclosure relates to a launch system, a launch vehicle for use with the launch system, and methods of launching a payload utilizing the launch vehicle and/or the launch system. The disclosure can provide for delivery of the payload at a terrestrial location, an Earth orbital location, or an extraorbital location. The launch vehicle can comprise a payload, a propellant tank, an electrical heater wherein propellant, such as a light gas (e.g., hydrogen) is electrically heated to significantly high temperatures, an exhaust nozzle from which the heated propellant expands to provide an exhaust velocity of, for example, 7-16 km/sec, and sliding electrical contacts in electrical connection with the electrical heater. The launch vehicle can be utilized with the launch system, which can further comprise a launch tube formed of concentric electrically conductive tubes, as well as an electrical energy source, such as a battery bank and associated inductor.
US10202206B2	System and method for aircraft power management A method implemented using at least one of the processor includes disposing a power source on a vehicle, wherein the power source is configured to power auxiliary loads of the aircraft. The method also includes connecting a power source disposed on a vehicle configured to engage an aircraft for ground operation, to auxiliary loads of the aircraft via an on-board power system. The method also includes performing energy management of the aircraft during the period of ground operation. The method further includes disconnecting the power source when an alternate electrical power is available to the on-board power system.
US10202204B1	Aircraft-runway total energy measurement, monitoring, managing, safety, and control system and method A total runway safety system (TRSS) and method measures, monitors, manages, and informs flight crew on the progress of takeoffs and landings and of any hazardous runway conditions. In some embodiments, the TRSS measures, monitors, and informs flight crew of longitudinal and lateral runway tracks thus preventing overruns and veer-offs during takeoffs and landings. In some embodiments, backscatter of infrared laser beams emitted by the aircraft is used to evaluate groundspeed and the reflectivity of the runway surface to make estimates of the surface conditions, roughness and contamination, which affects rolling and braking efforts and acceleration. In some embodiments TRSS evaluates runway surface and predicts tire-surface rolling and braking coefficient of friction. In some embodiments, GPS and similar navigation data, and ATC/airport reported runway braking conditions are evaluated along with the infrared laser, ultrasound and digital images to find best estimates of the runway remaining, current speed, acceleration, and jerk.
US10202201B2	Fire extinction design for an auxiliary power unit compartment of an aircraft The invention refers to an APU compartment, and a method for extinguishing a fire in an APU compartment. The APU compartment (1) comprises an APU (2), an exhaust (5), an aperture (7) providing a passage between the APU compartment (1) and the inside of the exhaust (5), and a fire detection system, wherein the APU compartment (1) of the invention is constructed as an air tight compartment, and additionally comprises a conduit (9) for providing external air to the APU compartment (1), a door (8) for closing the conduit (9) inlet, and a control unit (6) configured to close the door (8) when a fire is detected, such that when the door (8) is closed and the APU (2) is in operation, the air contained in the APU compartment (1) is sucked through the aperture (7) to be expelled out of the APU compartment (1) to extinguish the fire.
US10202196B2	Passenger seat headrest Apparatus and associated methods relate to an adjustable passenger seat headrest which includes articulating side wings, provides a more acute angle of support, and fits the width of a standard economy seat when stowed. In some embodiments, fabric may be stretched across the extreme ends of the wings to a center headrest, forming a hammock in which a passenger may rest their head. In an illustrative example, passengers may be provided with improved head support and comfort by employment of a mechanism that enables the side wings of the headrest to be articulated further apart, and/or extend out further from the back of the seat. These features may offer a more acute angle of passenger head support.
US10202195B2	Passenger cabin area A passenger cabin area, which is suitable for installation in an aircraft cabin, includes passenger seats arranged one behind another along a longitudinal axis of the passenger cabin area. The passenger cabin area also includes luggage compartments which are arranged, at least in certain sections, in an area between an inner face, which faces towards an interior space of the passenger cabin area, of a fuselage sidewall and the passenger seats, and have an access aperture which faces towards the passenger seats.
US10202187B2	Vortex generator arrangement A vortex generator arrangement for an aircraft including a surface section, a flap element pivotable between a first position and a second position, a biasing arrangement biasing the flap element towards the second position, retaining devices retaining the flap element in the first or second position, and a release device releasing the flap element from the first retaining device. The biasing arrangement, the first retaining device and the second retaining device are configured such that the second retaining device automatically retains the flap element in the second position after the flap element has been pivoted by the biasing arrangement from the first position into the second position. As soon as the torque exceeds a predetermined value, the second retaining device automatically releases the flap element, which pivots against the force of the biasing arrangement into the first position and is automatically retained therein by the first retaining device.
US10202186B2	Selectively thrusting propulsion units for aerial vehicles Aerial vehicles may include propulsion units having motors with drive shafts that may be aligned at a variety of orientations, propellers with variable pitch blades, and common operators for aligning the drive shafts at one or more orientations and for varying the pitch angles of the blades. The common operators may include plate elements to which a propeller hub is rotatably joined, and which may be supported by one or more linear actuators that may extend or retract to vary both the orientations of the drive shafts and the pitch angles of the blades. Operating the motors and propellers at varying speeds, gimbal angles or pitch angles enables the motors to generate forces in any number of directions and at any magnitudes. Attributes of the propulsion units may be selected in order to shape or control the noise generated thereby.
US10202180B1	Outboard motor and protective covering with rigging tray for outboard motor An outboard motor includes an engine coupled in torque-transmitting relationship with a propulsor via a driveshaft. A protective covering for the outboard motor includes a cowl that houses the engine within a closed interior thereof. An opening in an outer surface of the cowl provides access to the closed interior. A rigging tray can be inserted through the opening to a retracted position, in which a majority of the rigging tray is within the closed interior. A plurality of electrical lines extends from the engine and into the rigging tray from a first end thereof. Each electrical line in the plurality of electrical lines terminates in the rigging tray at a respective one of a plurality of electrical connectors. A second end of the rigging tray receives a complementary plurality of vessel electrical lines for connection to the plurality of engine electrical lines via the plurality of electrical connectors.
US10202177B1	Surf wake forming systems and methods with primary and secondary subtabs A wakeboat has a hull, the hull forming a wake when moving forward in the water, with a port disturbance and a starboard disturbance in the wake. A trim tab is supported by the hull at the stern of the hull. The trim tab comprises a primary subtab and a secondary subtab. One or more actuators may be optionally included to reposition the trim tab more into, or more out of, the water. Other systems and methods are also provided.
US10202176B1	Kayak with accessory receiver A watercraft is described that includes a shell defining a hull and a deck. The deck defines at least one cavity recessed into an upward facing surface of the deck. The at least one cavity is defined by a peripheral wall and a bottom wall. The at least one cavity is configured to receive and removably retain an accessory mount within the cavity.
US10202174B2	Buoy with integrated motion compensation A floating buoy includes a buoy hull having a tower that extends outwardly from the hull. A plurality of sensors are mounted either on the buoy hull, within the buoy hull, and/or on the tower. The plurality of sensors includes at least one met-ocean sensor, at least one ecological sensor, and at least one wind speed measurement sensor. The floating buoy further includes an autonomous power system that is configured to provide electrical power to each of the plurality of sensors. The wind speed measurement sensor may be a Light Detection and Ranging (LiDAR) wind speed measurement sensor, a surface level wind speed sensor, an ultrasonic wind speed sensor, or SODAR.
US10202171B1	Boat with reconfigurable running surface for wake adjustment A watersports boat includes a hull having an underside extending from a forward bow to n aft transom along a longitudinal centerline. The underside defines a running surface that contacts water when the hull moves therein. The underside includes one or more features that enhance the boat's performance.
US10202170B2	Hull for a floating wind turbine platform A hull for a semi-submersible wind turbine platform capable of floating on a body of water and supporting a wind turbine includes a keystone and at least three bottom beams extending radially outward of the keystone. Each bottom beam has a primary beam portion and a column base portion, wherein the column base portion is configured to support an outer column of the hull thereon, and wherein the primary beam portion defines a first ballast compartment therein. The first ballast compartment is in fluid communication with water in the body of water in which the hull is floating.
US10202168B2	Bicycle electronic system A bicycle electronic system comprising a battery unit, at least one operating unit and a power supply and communication bus, each of said units being connected to said bus is provided. The system comprises first means or controller for switching-off/(re)switching-on able to be activated/deactivated by a user and second means or controller for switching-off/(re)switching-on suitable for disconnecting/connecting said battery unit from/to said power supply and communication bus in response to the activation/deactivation of said first means or controller for switching-off/(re)switching-on. A battery unit and a method for switching-off/(re)switching-on a bicycle electronic system are also described.
US10202166B2	Integrated and self-contained suspension assembly having an on-the-fly adjustable air spring An integrated and self-contained suspension assembly having a gas spring integrated with a shock absorber (damper) is described. The rigid gas cylinder of the air spring is divided into a first gas chamber and a second gas chamber. A flow port connects the first and second gas chambers, and can be manually opened or closed by valve and a simple one-quarter turn rotation of an external knob to instantly switch the gas spring between two different spring rates. The different spring rates are functions of the separate or combined volumes of the two. gas chambers. The integrated suspension assembly is compactly packaged and self-contained, i.e., does not require any externalities, such as gas sources or electricity, to operate.
US10202164B2	Actuation device for a control cable for a bicycle gearshift The described actuation device comprises a casing, intended for the attachment to the handlebar of the bicycle, a cable-winding bobbin, angularly mobile in the casing about a main axis of the device, a first driving mechanism, acting on the bobbin to rotate it in a first angular direction, a second driving mechanism, acting on the bobbin to rotate it in a second angular direction opposite the first, as well as indexer assembly for removably holding the bobbin in predetermined angular positions. In accordance with the invention, the indexer assembly comprise first countering member, to counter the rotation of the bobbin in the first direction, and second countering member, distinct from the first countering member, to counter the rotation of the bobbin in the second direction. Asymmetric operation is thus obtained which allows active actuation to be set both for upward gearshifting and for downward gearshifting.
US10202161B2	Electric bicycle A bicycle includes a frame including first and second segments pivotable relative to each other between a folded position and an unfolded position. A magnet is fixed relative to the first segment. An electromagnet is fixed relative to the second segment and disposed in a magnetic field of the magnet when the frame is in the folded position. A controller is configured to power the electromagnet to repel the magnet to unfold the frame.
US10202158B2	Adjustable seat tube structure and bicycle An adjustable seat tube structure which is for adjusting a height of a saddle for a bicycle includes a lower tube, an upper tube and a piston set. The lower tube includes a top end. The upper tube is disposed at the lower tube and is limitedly moved relative to the lower tube. The upper tube is linked with the saddle and includes an upper end, an inner space, and a lower end. The upper end is protruded out of the top end, and the inner space is for receiving a gas. The lower end is corresponded to the upper end. The piston set includes a piston, a valve and a rod. The piston is disposed inside the inner space, and the lower end is moved relative to the piston. The valve is disposed inside the piston and the rod is connected to the piston.
US10202156B2	Stabilizer frame apparatuses and methods of using same A stabilizer frame apparatus may be configured for engaging a load transporting apparatus for purposes of moving a load. The stabilizer frame apparatus may have or include a first stabilizer bar and a second stabilizer bar where the stabilizer frame apparatus is configured to operatively integrate into a load structure. The first stabilizer bar may have a first end and a second end, and the second stabilizer bar may have a first end and a second end. The first end of the first stabilizer bar may be operatively coupled to the first end of the second stabilizer bar. Similarly, the second end of the first stabilizer bar may be operatively coupled to the second end of the second stabilizer bar. In a non-limiting embodiment, the load transporting apparatus may maintain a substantially parallel configuration between the sidewalls of the load structure during movement.
US10202154B2	Suspension and lock-out systems for a partially tracked vehicle A partially tracked utility vehicle and conversion are provided. The converted partially tracked utility vehicle has a chassis, front wheels, and a trailing link suspension. The trailing link suspension has a trailing link with a first end pivotably connected to the chassis and a second end pivotably connected to a walking beam at a walking beam pivot; a shock having a first end pivotably connected to a tension shaft and a second end pivotably connected to the trailing link; the walking beam further comprising a plurality of axle mounted bogey wheels for engaging a track of the partially tracked utility vehicle; a sprocket mounted to a traction drive of the utility vehicle for engaging and providing rotational power to the track; and an actuator attached to the chassis, the actuator having a shaft pivotably connected to the tension shaft and configured to rotate the tension shaft.
US10202152B2	Pickup box header and integrated toolbox assembly A pickup truck box assembly may include a header, an extruded upper rail, and a toolbox. The header may include a first flange extending at an angle away from a tailgate. The extruded rail may include a second flange for securing to the first flange. The toolbox is integrated with the rail and includes an extruded body having a rear wall, a forward wall, and a lower wall. The walls are arranged with one another to define a cell therebetween. A lid may be mounted to the forward wall for pivotal movement between at least a closed and an open position. Each of a pair of lateral channels may extend laterally beneath the cell and may be formed by an extrusion process with the walls. Each of a first and second truck bed side panel may be arranged with the forward and lower walls to form sidewalls of the toolbox.
US10202151B1	Side-by-side vehicle A cargo carrier having a depressed loading space includes a base carrier member, and a pair of right and left side carrier members disposed on right and left sides, respectively, of the base carrier member, and fastened to the pair of right and left rear frame members, respectively, from above. The base carrier member includes a bottom wall portion forming a bottom surface of the loading space, a front wall portion protruding upward from a front end of the bottom wall portion, and a pair of right and left side wall portions protruding upward from a right end and a left end, respectively, of the bottom wall portion. The pair of right and left side wall portions of the base carrier member are removably mountable on the pair of right and left side carrier members, respectively.
US10202149B1	ATV/UTV skid plate assembly A vehicle skid plate assembly includes multiple skid plate sections having closed apertures adapted to receive mounting bolts. The various skid plate sections are adapted to abut each other in a manner effective for the closed mounting bolt apertures of adjacent sections to overlay a single, linear array of bolt holes.
US10202146B2	Steering control device and steering-assisting torque control method thereof A steering control device capable of causing a steering torque to follow a target steering torque when a driver holds a steering wheel for steering, and making an adjustment so that the steering wheel returns to a neutral position at an appropriate speed, when the driver releases his or her hands from the steering wheel. A motor is controlled based on a motor steering assist torque, which is a sum of a first steering assist torque, which is proportional to an integral value of a deviation between the target steering torque and the steering torque, and a second steering assist torque, which is proportional to a motor rotational angular velocity and acting in a direction of suppressing a return speed of the steering wheel when the steering wheel returns to the neutral position.
US10202139B2	Steering system A steering system includes a movable member and a tooth member. The movable member includes first tooth arrangements. The movable member is movable together with a column jacket in a tilt direction. The movable member is movable in a right-left direction. The tooth member is supported by a lateral plate of an upper bracket so that the tooth member is located between the movable member and the lateral plate in the right-left direction. The tooth member includes: second tooth arrangements engageable with the first tooth arrangements; and curved elastic portions supporting the second tooth arrangements, with the second tooth arrangements inclined toward the upper bracket such that the second tooth arrangements are away from the first tooth arrangements. When the elastic portions are sandwiched between the movable member and the lateral plate and elastically deformed, the second tooth arrangements come into engagement with the first tooth arrangements.
US10202137B2	Heater device, steering wheel, and transport device A heater device includes: a base member; a heater wire; and a sensor which measures capacitance of the heater wire, wherein the heater wire forms a first wiring pattern and a second wiring pattern connected in series, the first wiring pattern and the second wiring pattern each include N wire blocks, the N wire blocks included in the first wiring pattern and the second wiring pattern are disposed in a manner that arrangement of the N wire blocks included in the first wiring pattern and arrangement of the N wire blocks included in the second wiring pattern are reversed in the circumferential direction of the rim and facing each other in a direction perpendicular to the circumferential direction, and a sum of sensitivity of the sensor to capacitance of a pair of wire blocks facing each other is substantially equal to that of another pair.
US10202135B2	Operations monitoring in an area An assembly for monitoring an area is provided. The assembly can include two or more cameras sensitive to radiation of distinct wavelength ranges. The fields of view of the cameras can be substantially co-registered at the area to be monitored. The assembly can include a computer system which can process the image data to monitor the area. The computer system can be configured to identify relevant objects present in the area, update tracking information for the relevant objects, and evaluate whether an alert condition is present using the tracking information.
US10202133B2	Method and system for timetable optimization utilizing energy consumption factors Systems and methods for synchronizing two or more vehicles operating on an electric transportation line to optimize energy consumption. A controller is provided having a computer memory component storing a set of computer-executable instructions, a list of braking intervals, and a list of acceleration intervals for the vehicles. The controller also has a processing component configured to execute the set of computer-executable instructions to operate on the list of braking intervals and the list of acceleration intervals to minimize an energy consumption of the electric transportation line over a determined period of time by shifting acceleration intervals to synchronize with braking intervals. A dedicated heuristic greedy algorithm and an energy model are implemented in the controller as part of the computer-executable instructions to achieve the improved energy consumption.
US10202132B2	Monitoring device for monitoring a railway track, associated method and monitoring system for monitoring a railway track A monitoring device monitoring a railway track, including a track interface connecting the monitoring device to the railway track. Also included is a detector detecting a first track pulse having a first duration emitted on the railway track and received through the track interface. The detector can detect a start and end time of the first track pulse. A charger is connected to the detector and has an energy storage element. Further, there is an emitter emitting a second track pulse on the railway track through the track interface by using energy stored in the energy storage element and the detector can send a transmit control signal to the emitter.
US10202131B2	Notifications involved with attaching or detaching connectable vehicles Navigation devices, systems, and methods for transmitting notifications to and/or receiving notifications from electronic devices associated with passengers of connectable vehicles are described herein. In one example, a method is provided for sending a notification regarding a planned detachment of a designated vehicle from a plurality of connected vehicles. The method includes receiving a navigation destination for a passenger of an initial vehicle, calculating a detachment time or detachment location of the designated vehicle from the plurality of connected vehicles based on the received navigation destination, and transmitting a personalized notification to an electronic device associated with the passenger regarding the detachment time or detachment location of the designated vehicle from the plurality of connected vehicles.
US10202127B2	User profile-based automatic parameter tuning system for connected vehicles The disclosure includes implementations for modifying an operation of an Advanced Driver Assistance System (“ADAS system”) of a vehicle based on one or more preferences of a user for the operation of the ADAS system. Some implementations of a method may include receiving a wireless message from a wireless network. The wireless message may include optimization settings data describing how to modify an operation of the ADAS system of the vehicle based on one or more preferences of a user for the operation of the ADAS system. The user may include a human who has reserved the vehicle for their use. The method may include modifying one or more control parameters of the ADAS system based on the optimization settings data so that the operation of the ADAS system conforms with the one or more preferences of the user for the operation of the ADAS system.
US10202125B2	Systems and methods for fault detection in lateral velocity estimation Methods and systems are provided for an improved system and method for validating vehicle lateral velocity estimation. The provided system and method employ an efficient validation algorithm to detect lateral velocity estimation faults. The method and system are robust to road uncertainties and do not require redundant estimations or measurements. The provided system and method offer a technological solution for real time validation of lateral velocity estimation using already existing vehicle sensors, and are independent of (i) road condition information, (ii) wheel torque information, (iii) tire model information, and (iv) tire wear information.
US10202123B2	Vehicle control system The vehicle control system includes a turning signal control unit configured to switch a turning signal of the vehicle between an off state and an on state according to the lane change control. The turning signal control unit maintains the turning signal in the on state until predetermined release conditions are satisfied when the lane change control in process is cancelled and the vehicle is switched to the manual driving mode.
US10202121B2	Stop control device An automatic stop controller (including a deceleration setting unit and a deceleration instruction unit) performs automatic stop control of a vehicle by using a first deceleration in response to (i) the detection or estimation of a stop intention by a stop intention detector or (ii) the detection or estimation of an unable-to-drive state of the driver of the vehicle by an unable-to-drive state detector while the vehicle is traveling. The automatic stop controller performs automatic stop control of the vehicle by using a second deceleration larger than the first deceleration in response to (i) the detection or estimation of the stop intention by the stop intention detector and (ii) the detection or estimation of the unable-to-drive state of the driver by the unable-to-drive state detector.
US10202119B2	Idle reduction system and method The present concept is method of controlling a vehicle's engine idle and includes the steps of monitoring a vehicles operating parameters with a controller and comparing parameters to preselected shutdown conditions. In the event shutdown conditions are met and the key is not in the ignition, the controller warns operator of impending shutdown. The controller intercepts the ignition key signal and simulates the vehicle key to be in the run position such that vehicle functions are operable as if key is in run position. The controller shuts down engine. The method may also include the steps of: the controller intercepting the ignition key signal and simulating the vehicle key to be in the accessory position such that vehicle functions are operable as if key is in accessory position.
US10202112B2	Systems and methods for preemptively modifying vehicle parameters according to predicted accelerations when merging System, methods, and other embodiments described herein relate to preemptively modifying operation of a vehicle according to predicted acceleration inputs. In one embodiment, a method includes, in response to identifying that an environmental context of the vehicle indicates that the vehicle is located at a traffic stop and that a roadway on which the vehicle is traveling includes merging lanes beyond the traffic stop, determining an acceleration profile for the vehicle that indicates a predicted acceleration that is anticipated to be provided by a driver as a function of the environmental context when approaching the merging lanes. The method includes adjusting the operating parameters of the vehicle according to the acceleration profile to preemptively optimize the vehicle in anticipation of an acceleration input from the driver. The method includes controlling the vehicle to accelerate based, at least in part, on the operating parameters upon receiving the acceleration input.
US10202111B2	Non-uniform displacement engine control system employing cylinder deactivation and method for controlling non-uniform displacement engine control system employing cylinder deactivation A non-uniform displacement engine control system employing cylinder deactivation includes a non-uniform displacement engine including a plurality of cylinders, the cylinders including at least two sizes of cylinders having different displacements, a motor connected to a driving shaft of the engine, a battery for supplying electrical energy to the motor, and a motor control unit for controlling the motor, wherein the motor control unit controls total torque by adjusting motor driving torque or energy regeneration torque and performs control such that cylinder deactivation (CDA) is performed after selectively performing a transient state transition based on a previous control mode at a time of switching to a CDA control mode.
US10202110B2	Air detector and air detecting method A hydraulic braking system includes: a master cylinder including a pressurizing piston, a rearward chamber, and a pressure chamber; and a rearward-hydraulic-pressure controller connected to the rearward chamber and including a pressure increase valve and a regulator for controlling a hydraulic pressure in an output chamber. An air detector includes: an upstream detector, including the rearward-hydraulic-pressure controller, for detecting presence or absence of air in an upstream portion based on a relationship between the hydraulic pressure in the output chamber and an open time of the pressure increase valve; and a downstream detector for detecting presence or absence of air in a downstream portion based on a relationship between a stroke of the pressurizing piston and the hydraulic pressure in the output chamber. The downstream portion includes a portion located downstream of the pressure chamber of the master cylinder.
US10202108B2	Brake apparatus and brake system A brake apparatus improved in mountability on a vehicle is provided. The apparatus includes a master cylinder 4 that generates hydraulic brake pressure by a driver's brake operation, and a stroke simulator 5 that creates an artificial operation reaction force of a brake operation member when the brake fluid flown out of the master cylinder 4 enters the stroke simulator 5. The master cylinder 4 and the stroke simulator 5 are integrally arranged to overlap each other in a perpendicular direction (as viewed from the perpendicular direction) when installed in the vehicle.
US10202107B2	Brake system for automobile A brake system including a main body having a first main chamber and a second main chamber divided by a main piston, a motor configured to move the main piston forward and move the main piston rearward, a first traction control valve installed in a first flow path, a second traction control valve installed in a second flow path, and a controller configured to control the motor, the first traction control valve, and the second traction control valve. When an anti-lock brake system (ABS) starting pressure is lower than an ABS critical value, the controller performs a low-pressure forward movement connection control that closes the first traction control valve and the second traction control valve, and moves the main piston forward to increase a first hydraulic pressure in the second main chamber.
US10202104B2	Window washer and washing method A window washer having a brushing arm mounted to a wiping arm of the window washer, and a motion conversion mechanism for converting back and forth rotational motion of the wiping arm to back and forth linear motion of the brushing arm, thereby the brushing arm rotates with the wiping arm motion, and in addition, linearly slides back and forth from the wiping arm, for brushing a window.
US10202103B2	Multi-modal context based vehicle theft prevention A motor vehicle management system provides theft prevention based on contextual information. The motor vehicle management platform includes sensing equipment that can provide input data to determine a context of the vehicle and an operator of the vehicle. The context can include location information of the motor vehicle and an identity of the operator of the motor vehicle. Based on permissions for the operator, the system can determine if a context of the vehicle violates permissions for the identified operator.
US10202097B2	Airbag unit An airbag unit is provided that can be quickly unfolded, and also retrofitted to an existing vehicle body. The airbag unit includes an airbag that covers, upon being unfolded, at least a part of a hood or a windshield outside a vehicle, a gas generator that ejects gas into the airbag, a cover bottom member that accommodates therein the airbag yet to be expanded and the gas generator, a cover lid member including a cover lid plate that covers the cover bottom member in which the airbag is accommodated, and a cowl cover attached to the cover lid plate between the hood and the windshield.
US10202094B2	Airbag device mounted on dashboard An airbag device mounted on dashboard, comprising an inflatable bag and a gas generator arranged inside a dashboard; wherein upon being filled with gas, the inflatable bag is provided with an upper convex chamber, a lower convex chamber and a concave chamber formed by a pull strap between the upper convex chamber and the lower convex chamber; rear of the upper convex chamber and the lower convex chamber are supported against a dashboard surface; and front of the upper convex chamber and the lower convex chamber form a protective surface. The inflatable bag of the airbag device has a reduced volume, and the gas generator matching the inflatable bag has a reduced output. Moreover, the inflatable bag can maintain the scope and effect of protection to occupant due to its adequate energy absorption ability.
US10202093B1	Barrier for an interior cab of vehicle The barrier for an interior cab of a vehicle is a removable barrier. The barrier for an interior cab of a vehicle is configured for use with a vehicle. The vehicle is defined with an interior space called a cab. The barrier for an interior cab of a vehicle forms a physical structure that prevents occupants of a section of the cab selected from the front section and the rear sections to move to the unselected section of the cab. The barrier for an interior cab of a vehicle attaches to the first head rest and the second head rest. The barrier for an interior cab of a vehicle comprises a first barrier and a second barrier. The first barrier and the second barrier are identical. The first barrier and the second barrier are positioned as mirror images of each other.
US10202084B2	System for fastening a door module to a car door A car fastening system includes a metal clip and a plastics locking body. When an insertion portion of the metal clip is completely inserted into a door module opening, at least two supporting tabs rest on an upper side of the door module and at least two first latching legs engage behind the opening. The insertion portion of the metal clip forms a receptacle for the plastics locking body. By insertion of the plastics locking body into the receptacle, at least two second latching legs are pressed elastically outwards out of an inoperative position such that the latching legs engage behind an opening in the car door. When the plastics locking body is completely inserted into the receptacle, a shifting movement of the second latching legs in order to release the engagement behind the opening in the car door is blocked by the plastics locking body.
US10202079B2	Electronic device and rear-view device An improved rear-view device for a motor vehicle includes an electronic device with at least one housing device, comprising at least one floor piece and a cover piece configured to be arranged on the floor piece. The floor piece and the cover piece, in the joined state, delimit an at least almost completely closed cavity. At least one first retaining means of a retaining unit, fixes the housing device in or on the rear-view device. At least one electronic module comprises at least one conductor unit and at least one contact means connected with the conductor unit. The conductor unit is arranged on a surface of the floor piece and/or cover piece and turned towards the cavity. The conductor unit comprises at least one carrier and at least one conductor track applied directly to the carrier. The contact means extends through the cover piece and/or through the floor piece with at least one protruding contact section and is accessible externally. The at least one carrier of the at least one conductor unit is formed at least in sections by a functional surface of the floor piece and/or the cover piece adjacent to the cavity and turned towards the cavity. The cover piece and/or floor piece forms a common component with the at least one first retaining means of the retaining unit.
US10202078B2	Rear-view device with vibration damping A rear-view device for a motor vehicle with vibration damping, includes at least one rear-view element which is mounted in a housing in an adjustable manner relative to the housing via an adjusting drive, where the adjusting drive includes at least one motor which can be adjusted via a control or regulating device in order to adjust the field of view, and the control or regulating device controls or regulates the motor via the energizing process of the motor depending on at least one variable, which is selected from a first detected variable and/or at least one second stored variable, during a driving process in order to counteract movements of the at least one rear-view element relative to the housing by adjusting the motor, said movements being caused in particular by the movements of the motor vehicle during the driving process of the motor vehicle.
US10202075B2	Sunroof comprising lighting means The invention relates to a laminated glass sunroof for a motor vehicle, including a means for illuminating the passenger compartment, said means including a set of light-emitting diodes incorporated between the glass sheets, in the insert material of the laminate, said sunroof having a maximum light transmission (LT) factor of at most 50%, the number and power of the diodes being selected in order to ensure useful lighting without causing detrimental overheating for the components of the glass panel.
US10202072B2	Brake warning lamp system A brake warning lamp system for a vehicle including: one or more primary brake lamps in a first set of brake lamps facing outwards from the rear of the vehicle; one or more secondary brake lamps in a second set of brake lamps facing outward from the rear of the vehicle and spaced from the primary brake lamps; sensing means for sensing deceleration of the vehicle; and control means operatively connected to the sensing means for selectively connecting the first and second set of brake lamps to the power supply of the vehicle to selectively illuminate the primary and/or secondary brake lamps.
US10202069B2	Illuminated vehicle container assembly and container illumination method An exemplary vehicle container assembly includes an outer bin, an inner bin received within the outer bin, and a lighting assembly that illuminates an interior of the inner bin through a translucent area of the inner bin. An exemplary vehicle container illumination method includes illuminating an interior area of an inner bin through a translucent area of the inner bin.
US10202064B1	Load securement block A load securement block includes a rectangular central block and two (2) rhomboid side blocks integral to opposite lengthwise sides of the central block and positioned in mirror image to each other. The block is made of closed cell high density foam. The block is configured to provide a protective and deformable barrier between a cargo strap and a cargo load being secured in place by the cargo strap. Alternate embodiments having different geometries are also disclosed.
US10202063B1	Support bracket for a tractor-trailer semi-truck cab rack A unitary support bracket for a tractor-trailer semi truck cab rack. The device comprises a metal panel surrounded by a metal flange. The unitary construction and curved design provide structural support for the heavy loads borne by tractor-trailer semi truck cab rack.
US10202061B2	Driver-free transport vehicle for the safe transportation of heavy loads The invention relates to a driver-free transport vehicle and to a method for the safe transportation of heavy loads which are in the form of loaded carriages which can be moved on castors, said vehicle having the following characteristics: a) vehicle housing having a central lifting mandrel for receiving and transporting a carriage by means of a docking traverse, with two drive wheels arranged on both sides of the vehicle housing, and in the center thereof, and at least one laser scanner system which is installed in the outer area of the vehicle housing; b) a drive motor for driving a hub spindle which presses, by means of a compression spring, the central lifting mandrel in a central opening of the docking traverse, and a system for supplying energy of the transport vehicle via inductive lines laid in the ground, by means of an induction current collector, is provided; c) an emergency stop system which comprises an emergency switch on the transport vehicle, the activation on the emergency stop switches triggering on each castor of the carriage, the simultaneous locking of a pressurized brake shoe.
US10202059B2	Load detection sensor and load detection sensor unit A load detection sensor 5 of the invention includes: a first electrode sheet 50 which includes first electrode 52 and a first contact point 53; a second electrode sheet 60 which includes a second electrode 62 and a second contact point 63; a spacer 70 which is disposed between the first electrode sheet and the second electrode sheet; one terminal 5A which is electrically connected to the first electrode 52; and the other terminal 5B which is electrically connected to the first contact point 53. A connection maintaining portion AP in which an electrical connection is maintained even when an external pressure is not applied thereto is formed by the first contact point 53 and the second contact point 63, and odd series of the switches SW electrically connected in series between one terminal 5A and the other terminal 5B are set.
US10202058B2	Vehicle seat A vehicle seat includes a seat back frame having a pair of side frames; a back panel main body constituted of resin and having a main wall and projections, the projections projecting away from the main wall to a seat width direction outer side; and back panel supports constituted of a resiliently deformable metal material and that each includes an attachment plate portion and a joining plate portion. The attachment plate portion is disposed along and is attached to a side wall portion of one of the pair of side frames, and the joining plate portion projects from an edge of the attachment plate portion toward the projection and is integrally joined to the projection.
US10202057B2	Surface skin-fastening structure for vehicle seat, operation lever device for vehicle seat, and vehicle seat A surface skin-fastening structure for a vehicle seat for fastening a surface skin to a framework of a vehicle seat, includes a base member which is integral with the framework, a surface skin-pressing member fitted into the base member, an interlocking member provided to an end of the surface skin, and slits provided to the base member. The base member has an extension section, which is an end edge that makes contact with a reverse surface of the surface skin. The slits extend in linear fashion along the end edge of the base member. With the surface skin covering the end edge of the base member, the interlocking member and the end of the surface skin are inserted into one opening of the slits and pass through the slits to appear from the other opening, and are stopped in a state of surface contact at the base member.
US10202056B2	Sedan slouch seat A seat assembly for an automotive vehicle comprises a seat cushion and a seat back pivotally coupled to the seat cushion for movement between a use position and a fold flat position overlying the seat cushion. A seat track assembly is coupled to the seat cushion for providing selective adjustment of the seat assembly between an upright design position and a reclined slouch position wherein the seat back is automatically pivoted rearwardly in response to forward sliding movement of the seat cushion. A sliding fold flat latch mechanism is operatively coupled to the seat back for slidably guiding the seat back during movement of the seat assembly between the upright design position and the reclined slouch position and for actuation between a locked condition retaining the seat back in the use position and an unlocked condition allowing pivotal movement of the seat back to the fold flat position.
US10202051B2	Speed control for back-drive power actuator A back-drive speed control system for incorporation into an actuated vehicle seating system includes an actuator having a permanent magnet and a coil that can move relative to each other to create a voltage across a first terminal and a second terminal. The actuator is adapted to move a linkage in an actuated vehicle seating system. A biasing member moves one or both of the permanent magnet and the coil such that the first terminal has a positive potential relative to the second terminal. The back-drive speed control system further includes a first diode and a Zener diode in series connected across the first terminal and the second terminal such that the forward current direction of the first diode is oriented in the opposite direction to the forward current direction of the Zener diode.
US10202048B2	Systems and methods for adjusting operation of a vehicle according to HOV lane detection in traffic System, methods, and other embodiments described herein relate to preemptively controlling one or more vehicle systems of a vehicle. In one embodiment, a method includes, in response to (i) detecting that a present traffic level along a route of the vehicle satisfies a congestion threshold and (ii) detecting that a type of roadway on which the vehicle is traveling is a highway, determining whether the vehicle is traveling in a high occupancy vehicle (HOV) lane by identifying whether a number of passengers in the vehicle satisfies an HOV threshold. The method includes adjusting the one or more vehicle systems within the vehicle according to whether the number of passengers satisfies the HOV threshold to cause the vehicle to operate efficiently while traveling along the route with the present traffic level.
US10202045B2	Vehicle with shielded power receiving coil A vehicle includes a power receiving portion that contactlessly receives electric power from a power transmitting portion provided outside the vehicle and includes a shield member that is arranged around the power receiving portion in the same plane as a plane in which the power receiving portion is arranged, wherein the shield member includes a first shield region having a high shielding function and a second shield region having a shielding function lower than that of the first shield region at a position around the power receiving portion.
US10202037B2	Reaction force output device A reaction force output device includes a driving part configured to transmit a driving force of a motor to a driving member through a gear mechanism to drive the driving member, thereby outputting a force in a direction opposite to an operating direction of an operation element to the operation element operated by a driver; and a controller configured to determine a control amount applied to the driving part based on an input value supplied from an outside, wherein the controller gradually increases the control amount, maintains the control amount at a constant value and then increases the control amount stepwise when increasing the control amount according to the input value.
US10202036B2	Fuel tank and fuel tank mounting structure In a fuel tank, high-rigidity portions are formed to protrude to an inner side from a part of a wall portion inside the fuel tank, the wall portion defining a closed space. A built-in part is fixed to the high-rigidity portions, and is also fixed to the horizontal portion. Therefore, when the fuel tank is deformed, deformation of the high-rigidity portions is restrained, so displacement of the built-in part is restrained. As a result, deformation is restrained in the horizontal portion of the fuel tank fixed to the built-in part that is restrained from being displaced when the fuel tank is deformed.
US10202035B2	Fuel shutoff valve A fuel shutoff valve is attached to the upper portion of a fuel tank and shuts off the communication between the inside of the fuel tank and a canister by opening and closing a vapor passage for communicating between the fuel tank and the canister. The fuel shutoff valve is configured with a first valve mechanism having a coil disposed on the inner periphery of a cylindrical valve chamber and a movable core, which enables to communicate between the fuel tank and the canister by lowering the level of the movable core, and a second valve mechanism which enables to communicate between the fuel tank and the outside thereof by shifting the level of the valve body which is disposed inside the movable core due to the pressure from the inside of the fuel tank or the outside thereof.
US10202032B2	Propulsion unit for a hydraulic hybrid vehicle, comprising an electric machine Propulsion unit for a hydraulic hybrid vehicle, comprising a transmission receiving power from a heat engine and from a second power source powered by hydraulic energy, to drive the wheels of the vehicle, characterized in that with the heat engine comprising no specific electric starter intended to drive same directly, one side of the casing (2) thereof, parallel to the axis, is fitted with an electric machine connected to a connecting shaft (12) which goes into the transmission.
US10202025B2	Vehicle roof module having a roof element and a roller blind apparatus A vehicle roof module having a transparent roof element and a roller blind apparatus arranged under the roof element and having a roller blind track, which is wound on a winding shaft and can be pulled out to cover the underside of the roof element, and which is guided by a drain edge when pulled out from the winding shaft, wherein, according to the invention, foam material attached on or around the roof element contains a drain edge body having the drain edge.
US10202021B2	Vehicle compressor control apparatus and control method The disclosure herein relates to a vehicle compressor control apparatus and control method, and more particularly to a vehicle compressor control apparatus for controlling compressor operating rate to allow braking according to brake negative pressure, while maintaining a minimum level of operation of the compressor. By preventing compressor deactivation during braking, the control apparatus assists in preventing moisture build-up of moisture on a windshield that decreases visibility for a driver and increases safety concerns. The apparatus includes: a compressor that reduces a temperature by compressing an air conditioner coolant; a data sensor that detects status data; and a controller that determines whether a brake negative pressure margin rate meets a first reference value when the status data satisfy a predetermined condition, and sets a compressor operating accordingly when the brake negative pressure margin rate meets a first reference value.
US10202017B2	Vehicular air-conditioning device In this vehicular air-conditioning device, an inner wall surface along a width direction of an air-conditioning casing is provided with guide portions each extending in a vertical direction. The guide portions are recessed on the outside in the width direction, forming recesses with respect to the inner wall surface. When an evaporator is inserted from above the air-conditioning casing and assembled inside, second seal portions of side plates disposed on side surfaces of the evaporator are respectively inserted into the guide portions, whereby the evaporator is guided along the vertical direction. The guide portions further include an entry portion disposed at an upper end portion of a first guide wall and expanding in a direction away from a second guide wall. Thus, the evaporator can be inserted into the air-conditioning casing from above in a preferable manner.
US10202014B2	Twist beam axle assembly and method of manufacturing same A twist axle assembly (20) of a vehicle includes a pair of trailing arms (22) and a twist beam (24) extending along an axis (A) between first and second twist beam ends (26, 28). The twist axle assembly (20) further includes a bushing (38) interconnected to each one of the first and second twist beam ends (26, 28) and a respective trailing arm (22) for establishing a weld-less joint between the twist beam (24) and the trailing arm (24). In an embodiment, the twist beam (24) and bushings (38) are tubular, and the bushings (38) are press-fit or molded onto the respective first or second twist beam ends (36, 38). In a further embodiment, the trailing arms (26) define an orifice (40) aligned on the axis (A), and the tubular bushings (38) are press-fit into the orifices (40) of the trailing arms (26) to establish the weld-less joint.
US10202010B2	Motor vehicle A motor vehicle is provided having a towing lug at a front end of the motor vehicle. The towing lug is directly accessible. A longitudinal axis of the towing lug is arranged substantially vertical or downward at an angle, such that a free end of the towing lug, at which a lug section of the towing lug is formed, points downward in the direction of a roadway.
US10202007B2	Pneumatic tire To provide a pneumatic tire which is improved in on-snow performance, while maintaining steering stability on dry road surface. The pneumatic tire is provided in a tread portion 2 with a pair of shoulder main grooves 3, a center main groove 4, shoulder land portions 6, and middle land portions 5. The middle land portions 5 are provided with middle lateral grooves 10 extending from the shoulder main grooves 3 toward the inside in the tire axial direction, while gradually decreasing the angle with respect to tire circumferential direction. The middle lateral groove 10 is provided with a groove bottom sipe 15 opened in the groove bottom.
US10202006B2	Tyre for vehicle wheels having improved tread pattern Tire for vehicle wheels includes a tread pattern defined by modules arranged circumferentially along the tread, each of the modules including: a) a first slanted transverse groove extending from a first shoulder portion in the first half of the tread to a first end located in the second half of the tread; b) a second slanted transverse groove extending from a second shoulder portion in the second half of the tread to a second end located in the first half of the tread; c) a third slanted transverse groove extending from the first shoulder portion to a third end located in the first half of the tread; d) a fourth slanted transverse groove extending from the second shoulder portion to a fourth end located in the second half of the tread; wherein: e) the first end is substantially located at an intermediate portion of the second slanted transverse groove; and f) the second end is substantially located at an intermediate portion of the first slanted transverse groove of a circumferentially adjacent module.
US10202005B2	Pneumatic tire The present technology provides a pneumatic tire that combines rolling resistance and wet grip performance while suppressing the occurrence of uneven wear. The pneumatic tire of the present technology has a cap rubber divided into a center portion that straddles a tire equator line and shoulder portions positioned on both sides thereof, a compound emphasizing wet grip performance and having a tan δ at 0° C. higher than that of the shoulder portions is disposed in the center portion and a compound emphasizing rolling resistance and having a tan δ at 60° C. lower than that of the center portion is disposed in both shoulder portions, and circumferential narrow grooves are formed on the respective shoulder sides of outermost main grooves in both the shoulder portions.
US10202002B2	Serviceable replacement spindle A replacement spindle that can be easily removed for service or replacement. The spindle may have a threaded projection corresponding to a threaded bushing, which may be secured within an axle tube. The spindle may be screwed into place for use, then unscrewed for service or replacement.
US10202001B2	Quick release device for bicycle wheel A quick release device for bicycle wheel is disclosed, including a mandrel, a wrench, at least one key, a limiting member, and an elastic member. The mandrel includes a shaft and an axial sleeve positioned at one terminal of the shaft and formed with multiple first grooves. The wrench includes a sleeve mounted on the axial sleeve, and is movable between a first position and a second position. The sleeve includes at least one second groove, wherein the key is positioned within one of the first grooves and the second groove when the sleeve is at the first position; the key is apart from one of the first grooves when the sleeve is the second position. The limiting member fits around the mandrel and includes a stopper. The elastic member is between the key and the stopper. Whereby, the application strength and lifetime can be increased with a lightweight feature.
US10201999B2	Method of manufacturing a lightweight wheel with high strength flexible spokes A method of manufacturing a lightweight wheel with high strength flexible spokes of the present invention, includes providing a rim and hub, and a plurality of lightweight, flexible and resilient spokes between the rim and hub made of fibrous material that causes the spokes to be both lighter in weight and stronger than comparable steel spokes. The wheel includes a nipple within the rim that receives the high strength spoke and allows for flexibility in adapting the spoke to wheels having differing shapes and sizes.
US10201998B2	Wheel with flexible wide-body spokes A wheel with flexible spokes, including a rim and hub, and spokes between the rim and hub made of fibrous material that causes the spokes to be both lighter in weight and stronger than comparable steel spokes. The spokes are also flexible and resilient such that they can bend while retaining their integrity and strength.
US10201996B2	Tape-like member, tape cartridge, and tape printing device A tape cartridge including a tape member, a tape core on which the tape member is wound, and a cartridge case in which the tape member and the tape core are accommodated. The tape member includes a folded tape main body having a print portion on a first side of the fold and a non-print portion on a second side of the fold. The folded tape main body includes an adhesive layer that pastes the print portion and the non-print portion together. An outermost surface of the print portion forms a print surface. The adhesive layer is provided on an inner surface of the print portion. A first release agent layer is provided abutting the adhesive layer. A second release agent layer is provided on an inner surface of the non-print portion such that the second release agent layer contacts the adhesive layer and the first release agent layer.
US10201995B2	Printer and method for selecting printing start position In accordance with an embedment, a printer comprises a sensor configured to detect a position of a paper conveyed in a conveyance path; a first setting module configured to set a plurality of start candidate positions which are candidates of a printing start position in a paper conveyance direction based on a sensing result of the sensor; a test printing module configured to carry out a test printing for specifying the start candidate position on the paper for each start candidate position set by the first setting module; a reception module configured to receive selection of one start candidate position from the start candidate positions specified by the test printing; and a second setting module configured to set the start candidate position received by the reception module as the printing start position.
US10201994B2	Ink jet printer A head unit of an ink jet printer is formed with a mist removing space for removing an ink mist generated when an UV ink is discharged by an ink jet head from a gap between the head unit and a table, where the mist removing space is formed with a gas introducing port, arranged at a position between the ink jet head and the LED, for the gas to be introduced from the gap side between the head unit and the table to the mist removing space, an intake port for the gas to be suctioned from the mist removing space toward a sirocco fan side by an airflow generated by the sirocco fan, and a gas discharging port, arranged separately from the intake port, for the gas to be discharged from the mist removing space.
US10201993B2	Tape cassette A tape cassette that includes a box-shaped cassette case whose outline being defined by a bottom wall, a top wall, and a side wall and including a plurality of corner portions, at least one tape contained within a tape containment area defined within the outline, a pair of cavities extending from the bottom wall and being provided between the tape containment area and the outline at opposite ends of a diagonal line connecting one of the corner portions to another of the corner portions, and a side face indicator portion provided in the side wall, indicating a type of the tape, and including a plurality of indicator portions disposed in a pattern in accordance with the type of the tape, each of the indicator portions being one of a switch hole and a surface portion.
US10201988B2	Tape cassette A tape cassette includes a box-like housing, a tape mounted within the housing, a hole and a first indicator portion. The housing includes a top wall having a top surface, a bottom wall having a bottom surface and opposing the top wall, and a front wall having a specified height and being formed along peripheries of the top wall and the bottom wall. The hole is provided in the front wall. The first indicator portion includes at least one first aperture and indicates a first element among a plurality of elements of a type of the tape. The first indicator portion is provided in a portion, spaced from the front wall, of the bottom wall. The hole and the one first aperture is located to intersect a virtual line orthogonal to the front wall when viewing along a vertical direction orthogonal to the top wall and the bottom wall.
US10201986B2	Sheet conveyance device and image forming apparatus including the same A sheet conveyance device transports a sheet to a predetermined processing unit, and includes a conveyance belt, a ventilation unit, and a suction unit. The conveyance belt has a first surface and a second surface, and is arranged to be opposed to the processing unit to transport the sheet on the first surface in a predetermined conveyance direction. On an upstream side of the processing unit in the conveyance direction, the ventilation unit blows out wind toward the sheet to adhere the sheet to the first surface of the conveyance belt. The suction unit is arranged to be opposed to the processing unit with the conveyance belt interposed therebetween to generate a negative pressure between the sheet adhered to the first surface by the ventilation unit and the conveyance belt, thereby bringing the sheet into close contact with the first surface of the conveyance belt.
US10201976B2	Inkjet printer An inkjet printer has a printing head, a sheet conveying mechanism, a carriage mounting a printing head and configured to be reciprocally movable in a printing area and non-printing area. A cap is provided to be movable between a capping position an uncap position. A controller of the inkjet printer is configured to execute a printing process, a standby process, and a capping process in which the controller causes the carriage to move to the non-printing area and moves the cap from the uncap position to the capping position. The controller causes the carriage to move into the printing area when the next printing command is received after the standby process is finished and before the carriage moving process has been completed.
US10201964B2	Treatment for reducing the toxicity of 3D-printed parts A method of reducing the toxicity of a 3D-printed part is provided. The method includes exposing the part to ultraviolet light sufficient to reduce the toxicity of the part. The toxicity of the ultraviolet light-treated part can be based on a comparison with the toxicity of a similarly prepared part not exposed to ultraviolet light.
US10201960B2	Lamination device A lamination device that laminates a laminate material on a front surface of a substrate includes a transport unit that transports the substrate in a transport direction, and first and second pressurizing units that pressurize the laminate material disposed on the front surface of the substrate. The second pressurizing unit is movable in the transport direction at a velocity higher than a transportation velocity of the substrate. When the laminate material is laminated on the substrate transported, the first pressurizing unit laminates the laminate material on the substrate from a central portion between an upstream end of the substrate in the transport direction and a downstream end of the substrate in the transport direction toward the upstream side of the transport direction, and the second pressurizing unit laminates the laminate material on the substrate from the central portion of the substrate toward the downstream side of the transport direction.
US10201958B2	Apparatus for manufacturing membrane electrode assembly An apparatus for manufacturing a membrane electrode assembly includes a suction roller, a porous base material supply roller, a porous base material collection roller, a laminated base material supply roller, an assembly collection roller, an application part disposed around the suction roller and a maintenance space for the maintenance of the application part. The porous base material supply roller and the porous base material collection roller are disposed on the opposite side of the suction roller from the maintenance space as seen in a horizontal direction. The porous base material supply roller and the porous base material collection roller are collectively disposed on one side of the suction roller. This configuration ensures the maintenance space on the opposite side of the suction roller, and lowers the height dimension of the manufacturing apparatus.
US10201957B2	Dye receiving layer composition, dye receiving substrate and method of fabricating the same A dye receiving sheet includes a substrate and at least one dye receiving layer on one side of the substrate. The dye receiving layer includes: (a) polymers, wherein the polymers include PVC or PVC-VA copolymer or a mixture thereof, and the polymers are in an amount of 60-85 parts by weight based on the total weight of 100 parts by weight of the dye receiving layer; (b) a plasticizer, wherein the plasticizer has a melting point higher than 40° C., and the plasticizer is in an amount of 10-35 parts by weight based on the total weight of 100 parts by weight of the dye receiving layer; and (c) heat stabilizer, wherein the stabilizer is in an amount of 2-8 parts by weight based on the total weight of 100 parts by weight of the dye receiving layer.
US10201955B2	Cellular glass corrosion under insulation system A cellular glass system for an outer surface of a pipe. An insulation layer surrounds the outer surface of the pipe. The insulation layer has an outer surface and an inner surface and comprises cellular glass. A foam fills an annular space between the outer surface of the pipe and the inner surface of the insulation layer and is configured to limit water intrusion into the annular space and attenuate sound. The system may also include another insulation layer and another foam layer between the two insulation layers.
US10201953B2	Steel foil and method for manufacturing the same A steel foil according to an aspect of the present invention includes a rolled steel foil; and a Ni having <111>//RD texture plated on an outermost layer of the rolled steel foil. Regarding the steel foil, a <111> pole density in an inverse pole figure of a rolling direction may be 3.0 or more and 6.0 or less.
US10201952B2	Multilayer film for flexible wrapping A subject of the present invention relates to a multilayer (or laminate) film, that can be used in the field of flexible wrapping, comprising at least 2 thin layers of material bonded together by a layer of an adhesive composition based on a styrene block copolymer. It also relates to a lamination process suitable for the manufacture of said film.
US10201950B2	Device for producing composite material, composite material produced using same, and method for producing composite material The present invention provides a device for producing a composite material, including: a mat production unit that produces a mat which forms a polymer film having a plurality of fiber layers; a fiber production unit that produces a wide-width fiber which is formed of a plastic resin with a single direction fiber layer; and a composite material production unit to which the mat and the double width fiber are supplied so that the mat and the wide-width fiber are laminated according to a predetermined order of lamination. Also, the present invention provides a composite material produced using the device and a method for producing said composite material.
US10201942B2	Method for producing and coating a lens A method for producing and coating a lens includes: applying a curable paste along the edge of a first molding shell and along the edge of the second molding shell, connecting the two molding shells by means of a sealing element to form a unit, casting a monomer into the unit, curing the monomer and the paste so that the lens is formed, detaching the sealing element from the unit, separating the lens from the two molding shells, placing the lens in a vacuum chamber of a vacuum-coating installation, and coating an optical surface of the lens, wherein no washing process is carried out between the step of separating the lens from the two molding shells and the step of placing the lens in the vacuum chamber.
US10201941B2	Systems for additively manufacturing composite parts A system comprises a delivery guide movable relative to a surface. The delivery guide is configured to deposit a continuous flexible line along a print path that is stationary relative to the surface. The system further comprises a vessel, configured to hold a volume of a liquid photopolymer resin and to apply a quantity of the liquid photopolymer resin to the non-resin component to create the continuous flexible line. The system further comprises a feed mechanism, configured to pull the non-resin component through the vessel and to push the continuous flexible line out of the delivery guide. The system further comprises a source of curing energy. The source is configured to deliver the curing energy at least to a portion of the segment of the continuous flexible line after the segment of the continuous flexible line exits the delivery guide.
US10201940B2	Apparatus and method to predetermine a mechanical property of a three-dimensional object built by additive manufacturing A computer implemented apparatus and method for receiving tool paths that a dispensing head follows to deposit roads of material for successively building object layers of a 3D object during an additive manufacturing process, generating simulated object layers of a simulated 3D object from the tool paths, wherein the simulated object layers represent an interior geometry of each one of the object layers, determining a contact surface area between adjacent ones of the simulated object layers, and determining a predicted mechanical property of the 3D object from the contact surface area and a material property of the material.
US10201936B2	Jig and processing method using jig A jig for assisting in aligning a plurality of rectangular workpieces is in the form of a plate having a plurality of grooves parallel to each other. The grooves have respective one ends aligned straight with each other and have a depth smaller than the thickness of the workpieces. After the workpieces have been fitted in the respective grooves, an adhesive tape is applied to the workpieces and the workpieces are transferred from the jig to the adhesive tape, so that the workpieces are arrayed in alignment with each other on the adhesive tape. The workpieces on the adhesive tape are prevented from being placed in different positions and orientations, and can subsequently be processed efficiently.
US10201935B2	Electric heating pad An electric heating pad for warming a patient. The electric heating pad may be a heated underbody support, heated mattress or heated mattress overlay. An embodiment of the heating pad includes a flexible sheet-like heating element including an upper edge, a lower edge, and at least two side edges. The heating pad may also include a shell covering the heating element and comprising at least two sheets of flexible material (e.g., two sheets may be one sheet folded over to form at least two sheets). The two sheets of flexible material may be coupled together about the edges of the heating element by a weld. The material of the two sheets may include urethane. In some embodiments, a catalyst to accelerate hydrogen peroxide decomposition is coated on or impregnated into an element within the shell, or on the interior surface of the shell.
US10201929B2	Raft techniques in three-dimensional printing The strength of a bond between two adjacent layers of a three-dimensional print is weakened by initiating fabrication of a top layer at a height greater than the processing height for the print. This technique may be used in particular at the interface between a raft or other support and an object being fabricated, after which the printing process may return to a regular process height for additional layers used to fabricate the remainder of the object.
US10201924B2	High-molecular polysilane and method for the production thereof for producing pre-ceramic molded bodies A method produces a polysilane by reacting at least two silane monomers and at least one alkali metal. The silane monomers have the following structural units: at least one aryl group, at least one alkyl group, at least one alkenyl group, and at least three halogen atoms. Wherein at least three of the halogen atoms are bonded to a silicon atom of one of the silane monomers, and the reaction step takes place in an ether-containing solvent, particularly preferably dioxane. The obtained polysilane has a high molecular mass and, at 100° C., a viscosity of 1,500 to 3,000 Pa·s. The polysilane is very suitable for being processed to form silicon carbide fibers and fiber composites.
US10201921B1	Molding system for preparing fiber-reinforced thermoplastic composite article The present disclosure provides a molding system for preparing a fiber-reinforced thermoplastic composite article. The molding system includes: a molding machine; a mold disposed on the molding machine and having a mold cavity for being filled with a composite molding material including a polymeric resin and a plurality of fibers; a processing module configured to generate an anisotropic stress distribution of the composite molding material in the mold cavity based on a molding condition for the molding machine; and a controller coupled to the processing module and configured to control the molding machine with the molding condition to perform an actual molding process for preparing the fiber-reinforced thermoplastic composite article. The anisotropic stress distribution of the composite molding resin is generated based in part on consideration of an anisotropic rotational diffusion effect of the fibers in the composite molding material.
US10201919B2	Head rest A headrest (400) is provided for a vehicle. The head rest (400) includes a front part (200) and a back part (100) with integrated lateral parts (104). The front part (200) and the back part (100) with integrated lateral parts (104) are formed in a complementary manner such that when they are assembled together, a closed space is formed in which a U-shaped curved support rod (300) can be inserted.
US10201918B1	Molding system for preparing fiber-reinforced thermoplastic composite article The present disclosure provides a molding system for preparing a fiber-reinforced thermoplastic (FRT) composite article, including a molding machine; a mold disposed on the molding machine and having a mold cavity to be filled with a composite molding resin including a polymeric material having a plurality of fibers; a processing module configured to generate an anisotropic viscosity distribution of the composite molding resin in the mold cavity based on a molding condition for the molding machine; and a controller coupled to the computing apparatus and configured to control the molding machine with the molding condition to perform an actual molding for the composite molding resin. The anisotropic viscosity distribution of the composite molding resin is generated by taking into consideration an orientation distribution of the fibers in the composite molding resin.
US10201916B2	Gas dispersion manufacture of nanoparticulates, and nanoparticulate-containing products and processing thereof In one aspect, the present invention relates to a method of making multi-phase particles that include nanoparticulates and matrix, which maintains the nanoparticulates in a dispersed state. A flowing gas dispersion is generated that includes droplets of a precursor medium dispersed in a gas phase. The precursor medium contains liquid vehicle and at least a first precursor to a first material and a second precursor to a second material. The multi-phase particles are formed from the gas dispersion by removing at least a portion of the liquid vehicle from the droplets of precursor medium. The nanoparticulates in the multi-phase particles include the first material and the matrix in the multi-phase particles includes the second material.
US10201913B2	Modular mount for transit concrete mixer A vehicle mountable, self-contained independent transit concrete mixer operating system is provided in two pre-assembled modular parts for mounting on a truck chassis. The system needs only power take-off, electrical and control system connections to be operable.
US10201911B2	Continuous process for forming a unitary mat A continuous process forms a unitary mat on a line having at least two conveyors spaced from each other. The process includes combining the isocyanate, an isocyanate catalyst, and a plurality of lignocellulosic particles to form a mixture and a self-polymerization product of the isocyanate in-situ in the mixture. The process also includes forming the unitary mat from the mixture on a first conveyer and transferring the unitary mat from the first conveyor to a second conveyor across a predetermined distance while maintaining structural integrity of the unitary mat. The lignocellulosic particles have a moisture content of 0.5 to 30 weight percent of water. Moreover, the continuous process is free of a step of adding water to the isocyanate, the isocyanate catalyst, the lignocellulosic particles, and/or the unitary mat.
US10201906B2	Flexible grip die-alignment arrangement A tool gripping and alignment plate arrangement, for accurately gripping and holding a tool in perfect alignment. The alignment plate arrangement comprises a flat unitary tool gripping plate. An irregular bore opening is formed in the tool gripping plate, for gripping a tool therein. The irregular bore wall opening is comprised of a first wall portion of 180 degrees in circumference, and a distortable second wall portion of less than 180 degrees in circumference. A bore-facing tool relief portion is arranged on a distal end of the distortable second wall portion.
US10201902B2	Force detector and robot A force detector includes a first base, a second base, and a sensor therebetween. The sensor includes a side wall having a terminal, a sensor plate connected to one end of the side wall, a lid connected to the other end of the side wall to configure an inner space, a charge output element in the inner space, and a conductor electrically connecting the charge output element to the terminal. The sensor plate is between the first base and the charge output element. The lid is between the second base and the charge output element. An elastic modulus of the sensor plate is lower than that of the side wall. The charge output element includes crystal. The sensor plate includes a metal selected from stainless steel, Kovar, copper, iron, carbon steel, and titanium.
US10201900B2	Control device, robot, and robot system A control device is capable of controlling each of a robot having a robot arm, and an imaging portion which is capable of capturing a first reference marker, a second reference marker, and a third reference marker, any one of the imaging portion, the first reference marker, the second reference marker, and the third reference marker is provided in the robot, and a posture of a reference surface parallel to a plane which passes through the first reference marker, the second reference marker, and the third reference marker, is acquired based on a first image in which the first reference marker is captured by the imaging portion, a second image in which the second reference marker is captured by the imaging portion, and a third image which captures the third reference marker by the imaging portion.
US10201896B2	Processing method, operation command generator, non-transitory computer-readable storage medium storing program, and processing system A processing method is for performing a processing with respect to a processing object in at least one field among biochemistry, biology, and biotechnology. The processing method includes transferring, using at least one arm of a robot configured to perform the processing, a container to a mover with the processing object attached on an inner surface of the container. The processing object is moved, using the mover, to a predetermined position on the inner surface of the container. The processing is performed, using a pipette mounted on the arm, with respect to the processing object at the predetermined position.
US10201894B2	Collet hydraulic hammer bushing A bushing assembly for a reciprocating device is provided. The bushing assembly includes a hollow bushing housing, a collet guide member, and an adjuster mechanism. The hollow bushing housing has a substantially cylindrical shape and an angled inner sidewall. The collet guide member is disposed radially inward from and contacts the angled inner sidewall of the hollow bushing housing. The adjuster mechanism contacts a lower surface of the collet guide member and urges the collet guide member along the angled inner sidewall of the hollow bushing housing.
US10201888B2	Substrate processing apparatus An embodiment of the present invention provides a buff process module. The buff process module includes: a buff table on which a processing target object is mounted; a buff head that holds a buff pad for applying a predetermined process to the processing target object; a buff arm that supports and swings the buff head; a dresser for dressing the buff pad; and a cleaning mechanism that is disposed between the buff table and the dresser and is for cleaning the buff pad.
US10201887B2	Polishing pad having grooves on bottom surface of top layer A polishing pad is provided. The polishing pad includes a base layer, a top layer, and multiple grooves. The top layer is located over the base layer and has a polishing surface and a bottom surface opposite to each other. The bottom surface is connected to the base layer. The grooves are formed on the bottom surface of the top layer.
US10201886B2	Polishing pad and method for manufacturing the same Provided is a polishing pad capable of sufficiently reducing minute defects to be generated after polishing on a workpiece which are detected in measurement for a particle size of 26 nm or smaller and capable of providing the workpiece with excellent surface flatness. The polishing pad includes a polishing layer having a polishing surface to polish a workpiece, and includes, in the side opposite to the polishing surface of the polishing layer, an intermediate layer having an amount of deformation C larger than that of the polishing layer, a hard layer having an amount of deformation C smaller than that of the polishing layer, and a cushion layer having an amount of deformation C larger than that of the intermediate layer, in which each of the amounts of deformations C is defined as an amount of deformation in the case of compression in a thickness direction, and the intermediate layer, the hard layer, and the cushion layer are laminated in this order from the side of the polishing layer.
US10201885B2	Rotational abrasive micro/nano-finishing Disclosed herein is a method for inner surface finishing of a workpiece, in which the inner surface of the workpiece defines an opening with axial symmetry around the longitudinal axis of the workpiece. The method may include the following steps. An abrasive medium may be poured inside the opening; urging the abrasive medium to rotate about the longitudinal axis, thereby imposing a centrifugal force on the abrasive medium to accelerate the abrasive medium outwards from the center of rotation towards the inner surface of the opening, where the abrasive medium impacts the inner surface of the opening; and the workpiece may be rotated about the longitudinal axis in a direction opposite the first direction, concurrently.
US10201883B2	Air tool monitoring apparatus, air tool incorporating same, system for monitoring multiple air tools equipped with same, and methods of using same An air tool monitoring apparatus includes a housing having a hollow chamber formed therein, and also having an inlet and an outlet formed therein, each of the inlet and an outlet in fluid communication with the chamber. The apparatus also includes a first sensor for sensing a condition indicative of tool usage, a battery disposed in the housing, and a microprocessor operatively connected to the housing and including a timer, a memory storage module, and a unique identifier. The apparatus further includes a switch for starting and stopping the timer, and a communication device for sending data from the microprocessor to a data collection device. The apparatus may additionally include a second sensor for sensing a condition indicative of tool wear. Methods of using the apparatus, along with systems for monitoring and reporting on usage of multiple air tools equipped with the apparatus, are also described.
US10201878B2	Laser cutting head with controllable collimator having movable lenses for controlling beam diameter and/or focal point location A laser cutting head includes a controllable collimator with movable collimator lenses for controlling beam diameter and/or focal point location. The laser cutting head may be used in a laser cutting system with a control system for controlling the position of the movable collimator lenses. The lenses may be moved, for example, to adjust the beam spot size for cutting different types of material or material thicknesses. The lenses may also be moved to adjust a focal point back to the workpiece after changing the distance of the laser cutting head relative to the workpiece.
US10201873B2	Friction stir spot welding device and friction stir spot welding method A friction stir spot welding device includes a pin member, a shoulder member, a rotation driving unit, a tool driving unit, a position detector, and a controller, wherein the controller sets as reference position of the tip end surface of the pin member or shoulder member at a time point when the pin member tip end surface or shoulder member contacts an obverse surface of an object and controls the tool driving unit reducing a pressing force to the object by the pin member and pressing force to the object by the shoulder member in a next welding process, and/ or controls the rotation driving unit reducing the pin member rotational speed and shoulder member rotational speed in the next welding process, in case where a first position is the position of the tip end surface of the pin member or the shoulder member is within a first region.
US10201870B2	ARC welding device with automatic selection of the metal transfer rate A device for arc welding with fusible wire including a device for setting the wire speed and a device for selecting a metal transfer rate type, the device for setting the wire speed being maneuverable by the hands or fingers of an operator. The device for selecting a metal transfer rate type cooperate with the device for setting the wire speed in such a way as to allow the operator to set the wire speed by maneuvering the device for setting the wire speed and to automatically select, on the basis of the wire speed setting, a metal transfer rate type.
US10201869B2	Engine drive welder and methods and systems of controlling the same Embodiments of the present invention are engine drive welding and/or cutting systems which optimize the utilization of engine drive systems, including hybrid engine drive systems. Embodiments include modular systems which allow for the remote utilization of a battery powered module which can be separated from an engine drive generator power supply. Other embodiments include engine drive power supplies that can communicate with a load coupled to the power supply, such as welders, cutters and wire feeders to determine an optimum operational level. Further embodiments include engine drive power supplies that can be coupled together to optimize fuel and system usage.
US10201866B2	Method and soldering device for selective soldering with at least one solder nozzle and another functional element which are moved synchronously by a movement device A soldering apparatus for selective soldering, comprising a solder bath for holding the molten solder at least one solder nozzle a solder pump for conveying solder from the solder bath through the solder nozzle a movement device for the relative movement of the solder nozzle and an assembly to be soldered wherein several solder nozzles are provided in several solder nozzle assemblies, with each solder nozzle assembly having one or more solder nozzles and wherein each solder nozzle assembly may be assigned an assembly, and the movement device is designed for synchronous movement of the several solder nozzle assemblies relative to the respective assemblies in the horizontal X-Y plane, and the soldering machine is so designed that the individual solder nozzle assemblies and the respective assemblies may be moved towards one another and independently of one another in the vertical direction (Z-direction) by means of a coupling device.
US10201862B2	Cutting tool having a coolant chamber with an integrally formed coolant deflection portion and tool body A cutting tool includes a replaceable cutting insert and a tool body. The tool body includes a tool body surface and an insert pocket recessed therein. The cutting insert is releasably retained in the insert pocket. The tool body includes at least one coolant duct that has an outlet orifice that opens out in a coolant chamber. The coolant chamber is bounded on a side opposite the outlet orifice by a coolant deflection portion that is integrally formed with the tool body in a unitary one-piece construction and at least partially overhangs the outlet orifice in a direction towards the insert pocket. The coolant deflection portion has a chamber deflection surface configured to deflect a coolant in the direction of a cutting edge of a cutting insert seated in insert pocket.
US10201860B2	Drill bit with an exchangeable cutting portion A drill bit is disclosed. The drill bit has a cutting portion having an annular portion, where the annular portion has a first end on which is disposed a cutting element and a second end that includes an outer insertion element and a stop shoulder. The drill bit has a drill shaft portion having a cylindrical drill shaft, where the drill shaft has an inner insertion element with an end face on a side of the drill shaft facing the cutting portion. The outer insertion element and the inner insertion element together form a plug connection in an insertion direction that is parallel to the axis of rotation and the insertion elements are connectable to each other via a pin element that is movable into a slot-shaped recess. The pin element is attached to an outside of the inner insertion element and the outer insertion element has the slot-shaped recess.
US10201852B2	Silver particle synthesizing method, silver particles, conductive paste producing method, and conductive paste A silver particle synthesizing method includes reducing a dispersant from first silver particles each covered with the dispersant to obtain second silver particles. The method further includes synthesizing third silver particles each having a larger particle diameter than the second silver particles by causing a reaction between a silver compound and a reductant in a liquid phase containing the second silver particles.
US10201850B2	Local extrusion device for high-pressure casting The disclosure provides a local extrusion device for high-pressing casting. The local extrusion device for high-pressure casting includes an extrusion core sleeve, an extrusion rod, an extrusion oil cylinder and an extrusion oil cylinder piston. The extrusion oil cylinder includes the extrusion oil cylinder piston, the extrusion oil cylinder piston is connected with the extrusion rod, the extrusion rod is positioned in the extrusion core sleeve, and the extrusion core sleeve and the extrusion oil cylinder are fixed.
US10201849B2	Composition, a method for preparing said composition, a method for preparing a rigidified fabric, the rigidified fabric so obtained, a filtration device, methods for the manufacture of the filtration device, installation, process and use of said filtration device for the filtration of a liquid metal or an alloy thereof A composition for preparing a rigidified fabric made of heat resistant fibers or threads of heat resistant fibers, preferably of woven threads made of heat resistant fibers, said composition comprising a mixture of a product A and a product B, the product A being obtained by polymerization of carbohydrate units, natural or synthetic, preferably a saccharide, and more preferably a sugar such as glucose, fructose, galactose, sucrose, maltose, lactose, etc.; and the product B consisting of at least one additive such as a binding agent. A method for preparing said composition, a method for preparing a rigidified fabric of heat resistant fibers, the method for the manufacture of filtering devices, filtering devices so obtained, their use for the filtering of metal, and installation and process involving said filtering devices.
US10201848B2	Casting device A casting device is provided with: a positioning member that is provided to a base and comes into contact with an upper mold and a slide member to define the positions of the upper mold and the slide member at the time of mold clamping; and a restraining force-applying mechanism for applying a restraining force to the slide member in a direction opposite a pressing force acting on the positioning member from the slide member at the time of mold clamping of the slide member.
US10201839B2	Washing system of machine tool A washing system that can reliably remove chips attached to the surface of a jig on which a workpiece is placed. The washing system includes a nozzle, a manipulator for moving the nozzle, an imaging part for capturing an image of a region on which a workpiece is placed, a chip detecting part for detecting a chip in the region based on the image captured by the imaging part, a arrangement determining part for determining a position and posture of the nozzle when the fluid is sprayed to the chip, a manipulator controlling part for controlling the manipulator so that the nozzle is located at the determined position and posture, and a fluid supplying part for injecting, through the nozzle, the fluid that has been supplied to the nozzle.
US10201838B1	MICR-embedded cleaning card for check-reading machines An example cleaning card for cleaning a check-reading machine can include at least two opposing surfaces. The opposing surfaces can include a cleaning feature configured to clean at least one component of the check-reading machine when the cleaning card is fed through the check-reading machine. An ink can be located on at least one of the opposing surfaces. The ink can define a set of Magnetic Ink Character Recognition (MICR) characters capable of identifying the cleaning card. The position of the set of MICR characters can coincide with a routing field of the cleaning card as defined in accordance with the standard of the American National Standards Institute (ANSI) X9 family of standards. Other systems, apparatuses, and methods are also described.
US10201834B2	Ultrasound observation apparatus and manufacturing method of ultrasound observation apparatus An ultrasound observation apparatus includes: a sheet including a first transducer, a first transducer region, a columnar portion, and a film portion configured to connect a plurality of first upper electrodes in the first transducer region and a second surface of the columnar portion in an arrangement direction C; and a bonding portion provided between the first transducer positioned on a second end portion in the first transducer region and the columnar portion and configured to maintain a state in which the sheet is rounded such that the film portion becomes an external surface, and the first transducer positioned on the second end portion and a first surface of the columnar portion are attached to each other.
US10201833B2	Modular projector for marine seismic source An apparatus is disclosed which may include a plurality of marine seismic sources. According to some embodiments, these marine seismic sources may include a plurality of piezoelectric components. Such an apparatus may provide a useful sound pressure level for conducting marine seismic surveying. According to some embodiments, a conduit may be coupled between the plurality of marine seismic sources and a gas reservoir external to the plurality of marine seismic sources. The conduit may in some embodiments have at least one adjustable dimension for changing a frequency of the apparatus. The apparatus may be used in a method of marine seismic surveying.
US10201832B2	Methods for dispensing a substance on a surface A method of dispensing a substance along a path is provided. The method includes supplying the substance to a dispenser. The method also includes moving the dispenser along a virtual travel plane parallel to the path and passing through two contact points of the dispenser, while maintaining a contact portion of the dispenser in communication with a surface. The method also includes monitoring a leading portion of the bead and generating a signal responsive to at least one characteristic of the leading portion. The method further includes controlling at least one of the speed of the dispenser along the path or the flow rate of the substance to the dispenser to provide a substantially uniform cross-sectional shape of the bead along the path.
US10201831B2	Coating inspection method Provided herein are methods and compositions which allow for efficient inspection, maintenance and repair of ceramic coatings.
US10201828B2	Coating system and coating method A coating system and a coating method are provided. The coating system includes: a coating device, a detecting device, and an adjusting device, wherein, the coating device is configured for applying a coating material on a substrate; the detecting device is configured for detecting a film thickness of the coating material at a measuring point when the coating device is applying the coating material and sending the detected film thickness to the adjusting device; the adjusting device is configured for selectively generating a preset feeding speed according to the film thickness and sends the preset feeding speed to the coating device. The coating system and the coating method are capable of adjusting film thickness in real time.
US10201827B2	Adhesive dripping device for adhesive dispensing equipment An adhesive dripping device for adhesive dispensing equipment includes: a housing defining a mounting chamber therein, a lower end of the housing being provided with a nozzle communicating with the mounting chamber; a core stem mounted in an upper portion of the mounting chamber; an electromagnetic coil wound around the core stem; an elastic member fitting over the core stem; an adhesive dripping assembly mounted in the mounting chamber below the elastic member and configured for dripping adhesive through the nozzle; a pressure sensor mounted on a top end of the mounting chamber and abutting against an upper end of the elastic member; and a control unit electrically connected to the pressure sensor and the electromagnetic coil and configured for adjusting a current in the electromagnetic coil according to a pressure detected by the pressure sensor, so as to control an adhesive dripping amount of the adhesive dripping assembly.
US10201826B2	Liquid coating method, liquid coating apparatus, and computer-readable storage medium Disclosed is a liquid coating method. The method executes processes of: coating a coating liquid in a spiral form on a surface of a substrate by ejecting the coating liquid from the ejection nozzle while moving the ejection nozzle in a predetermined direction between the rotary axis and a peripheral edge of the substrate during rotation of the substrate; making a linear velocity at an ejection position of the coating liquid from the ejection nozzle substantially constant by reducing a number of rotations of the substrate as the ejection position is positioned closer to the peripheral edge of the substrate; and making an ejection flow rate of the coating liquid ejected from the ejection nozzle substantially constant by changing a gap between the ejection port of the ejection nozzle and the surface of the substrate based on a flow rate of the coating liquid before ejection from the ejection nozzle.
US10201823B2	Paint sprayer attachment A paint sprayer attachment that prevents over spray mist from dispersing into the open air, thus allowing a user to operate a paint sprayer without wearing a mask, includes a spray hood, a first edger, a second edger, a first roller assembly, and a second roller assembly. The spray hood is a thin-walled, dome-like structure to which the first edger, the second edger, the first roller assembly, and the second roller assembly are attached. The first edger and the second edger enclose the sides of the spray hood, and provide non-abrasive surfaces for applying paint to a desired surface. A first paint roller from the first roller assembly and a second paint roller from the second roller assembly are positioned at opposite ends of the spray hood, wherein the first paint roller and the second paint roller enclose the front and back of the spray hood.
US10201815B2	Method for thermal ablation of pigging devices The present disclosure provides for a novel pig design and method of retrieval based on thermal ablation. The pig comprises an external layer and an inner core, where the inner core further comprises at least one incendiary charge comprising at least one exothermic material. When ignited via an ignition source, the incendiary charge releases the exothermic material into one or more thermal dispersion channels. The exothermic material melts the interior of these thermal dispersion channels thereby distributing the exothermic material throughout the pig device causing its destruction via thermal ablation. The destroyed pig can then be easily retrieved from its location in a pipe, as detected via radio signals, without the need for costly excavation of large sections of the pipe.
US10201814B1	Hammer The various embodiments disclosed and pictured illustrate a hammer for comminuting various materials. The embodiments pictured and described herein are primarily for use with a rotatable hammermill assembly. The double end hammer includes a connection portion having a slot therein and two contact ends for delivery of energy to the material to be comminuted. The contact ends may be formed with a cavity therein. The contact ends may also be formed with an angle on the contact end periphery. The cavity and/or the angle on the contact end periphery may be used with hammers other than the double end hammers.
US10201812B2	Methods for conducting multiplexed assays The invention relates to methods for conducting solid-phase binding assays. One example is an assay method having improved analyte specificity where specificity is limited by the presence of non-specific binding interactions.
US10201808B2	Method for preventing a photocatalyst from decreasing in hydrophilicity Disclosed is a method for preventing a photocatalyst from decreasing in hydrophilicity due to contamination by components seeping from a sealing material for anchoring a construction material, exterior material, glass structure, or other article on which a photocatalyst layer is formed. In said method, a transparent sealing-material-component seepage-prevention layer, which contains a modified epoxy resin comprising polymerizable unsaturated monomers graft-polymerized onto or copolymerized with an epoxy resin, is formed on the surface of the sealing material. Said polymerizable unsaturated monomers include a carboxyl-group-containing monomer, and a modified epoxy resin obtained by a carboxyl-group/epoxy-group reaction after graft polymerization or copolymerization is more favorable.
US10201806B2	Catalyst and process for the conversion of oxygenates to olefins The present invention relates to a catalyst for the conversion of oxygenates to olefins, wherein the catalyst comprises one or more zeolites of the MFI, MEL and/or MWW structure type and particles of one or more metal oxides, the one or more zeolites of the MFI, MEL and/or MWW structure type comprising one or more alkaline earth metals selected from the group consisting of Mg, Ca, Sr, Ba and combinations of two or more thereof, wherein the catalyst displays a water uptake of 9.0 wt.-% or less, as well as to a process for the production thereof and to its use, in particular in a process for converting oxygenates to olefins.
US10201799B2	Packing element for a structured packing with specific mounting clips The present invention relates to a packing element for a structured packing including at least two adjacent corrugated sheets, wherein each of the corrugated sheets has a plurality of alternately oriented peaks and troughs, wherein adjacent corrugated sheets are oriented such that the corrugations of the adjacent corrugated sheets intersect in crisscross fashion with the corrugations of the corrugated sheets extending obliquely relative to the vertical direction, wherein each corrugated sheet contacts each of the adjacent corrugated sheets at points of intersection between the corrugations of the corrugated sheet and those of the adjacent corrugated sheets, wherein all corrugated sheets are tied together by means of at least one rod, wherein the at least one rod penetrates the corrugated sheets perpendicularly to the longitudinal section of the corrugated sheets, wherein on the at least one rod before the first corrugated sheet of the packing element and/or after the last corrugated sheet of the packing element at least one mounting clip is provided for fixing the corrugated sheets on the rod, wherein the mounting clip has a central part forming a coupling portion for coupling the mounting clip to the rod and two opposing lateral parts forming a clamping portion for a clamping engagement with the corrugated sheet, wherein the lateral parts are connected with the central part and angled with respect to the central part.
US10201795B2	Microcapsules comprising hydroxyalkyl cellulose The application describes an aqueous dispersion of microcapsules, wherein the shell of the microcapsules comprises at least one polyurea and the core comprises one or more lipophilic components with the proviso that the core does not contain a fragrance, and having a percentage of the shell weight with reference to the total weight of the capsules of 5 to 40% and wherein the microcapsules have a volume average diameter of 15 to 90 μm and the dispersion comprises hydroxyalkylcellulose and the use of such a dispersion.
US10201791B2	Method for producing carbon particles by detonation A production method of a carbon particle by a detonation method includes a step of disposing an explosive substance in a periphery of a raw material substance, and a step of subjecting the explosive substance to a detonation. The explosive substance is a liquid at normal temperature and normal pressure. The raw material substance contains an aromatic compound having 3 or more nitro groups.
US10201790B2	Blender for food and beverages A motorized kitchen apparatus including a processor module coupled to a non-volatile storage medium for storing a custom sequence; a user interface having a speed or power selection element and a record selector; a motor controller coupled to a blender motor, the processor module coupled to the motor controller for controlling operation of the motor according to user input selections. Upon user selection of the record selector, the processor module enters a record mode and records a sequence of user inputs made through the user interface; the sequence including data indicative of a power profile selected by the user over a period of time, and upon completion of the record mode, the processor module saves a custom sequence indicative of the recorded sequence to the non-volatile storage medium for subsequent playback.
US10201787B2	Slurry dispenser for radioisotope production A slurry dispensing system is disclosed. A peristaltic pump may direct a flow of slurry out of a horizontal mixer to a slurry dispenser. This slurry dispenser may be operated on a programmed manner by a controller to dispense slurry into a container. Both a bypass valve and a dispensing valve of the slurry dispenser may be opened/closed on a programmed basis by the controller to deliver slurry to a container, such as a glass column. Slurry may be intermittently directed into a metering chamber of the slurry dispenser, while the remainder of the slurry being directed into the slurry dispenser may be recirculated back to the horizontal mixer.
US10201786B2	Fluid mixer and system using the fluid mixer The present invention relates to a fluid mixer having a fluid inlet (5), a first passage (1) which connects to the fluid inlet, a helical flow passage (2) which connects to the first flow passage, branched flow passages (4) which are branched from the helical flow passage, a second flow passage (3) to which the branched flow passages individually connect, a connection flow passage (7) which connects the first flow passage and the second flow passage, and a fluid outlet (6) which connects to the second flow passage. The branched flow passages are individually branched from different positions in the direction of flow through the helical flow passages. The branched flow passages which are branched from the helical flow passage individually connect to the second flow passage at different positions in the direction of flow through the second flow passage.
US10201784B2	Method for forming perforated graphene with uniform aperture size A method of forming a filter with uniform pore sizes includes synthesizing a moiety so as to form a plurality of like platelets having a precisely sized pore extending therethrough, distributing the plurality of like platelets about a membrane having apertures therethrough, and bonding the plurality of platelets around the apertures to form precisely sized pores through the membrane. A filtration membrane is also disclosed which provides a porous membrane having a plurality of apertures therethrough, and a plurality of platelets, wherein each platelet has a pore therethrough. The platelets are positioned over or in the apertures.
US10201782B2	Exhaust gas scrubber According to principles of the embodiments as disclosed herein, an exhaust gas scrubber system with a two-chamber exhaust gas scrubber is provided which allows for scrubbing of exhaust gases without the use of chemicals. In particular, the process fluid used in the system may be seawater. The exhaust gas scrubber includes a first scrubbing chamber having a fluid spraying system, such as an array of atomizing nozzles that spray atomized seawater into the chamber. The atomized seawater aids in reducing the concentration of sulfur oxides in an exhaust gas stream.
US10201781B2	CO2 recovery device and CO2 recovery method An absorption column is equipped with: a CO2 absorption section absorbing CO2 from CO2-containing exhaust gas using a lean solution; a main rinse section recovering an entrained CO2 absorbent using rinse water; a rinse water circulation line circulating a rinse water containing the CO2 absorbent recovered in a liquid storage section of the main rinse section; a pre-rinse section provided between the CO2 absorption section and the main rinse section; a rinse section extraction liquid supply line extracting a portion of the rinse water containing the CO2 absorbent from the rinse water circulation line, and introducing the same into a reflux section of an absorption liquid regeneration tower; and a refluxed water supply line extracting a portion of refluxed water, introducing the same as pre-rinse water for the pre-rinse section, and connected on the pre-rinse section side.
US10201775B2	Regulating flow of pressure swing adsorbers A pressure swing adsorption (PSA) system for purifying a feed gas is provided. The PSA system may have a first adsorber bed and a second adsorber bed, each having a feed port, a product port, and adsorbent material designed to adsorb one or more impurities from the feed gas to produce a product gas. The PSA system may also have a first valve configured to direct flows of the feed gas and the product gas through a network of piping. The PSA system may further have a first orifice configured to regulate a flow rate of gas between the first adsorber bed and the second adsorber bed during the pressure equalization step and a second orifice configured to regulate a flow rate of gas between the first adsorber bed and the second adsorber bed during the purge step.
US10201766B2	Compact distributor tray for offshore gas/liquid contact columns The invention is a distributor tray for at least one a gas/liquid heat and a material exchange column comprising passages for passing gas through the tray. The tray has an upper plate (P1) and a lower plate (P2) with each plate having at least two distinct liquid passages. The openings (10 and 11) of the upper plate (P1) are positioned at distinct elevations with at least one of the liquid passages (10) of upper plate (P1) having a lower elevation communicating with one of the liquid passages of the lower plate through a supply line (9). The invention also relates to a gas/liquid heat and/or material exchange column equipped with a distributor tray (2) in accordance with the invention and to a floating barge having a column and to the use of the column.
US10201761B2	Attachment and game system An attachment configured to be attached to a game controller with a camera is provided. The attachment includes a housing having a support portion which supports the game controller and an operation portion in the housing. The support portion supports the game controller such that a direction of shooting of the camera is oriented to the inside of the housing and supports the game controller such that a field of view of shooting with the camera includes a first region including a first indication in the housing as a subject and a second region including a second indication in the housing as a subject. The first indication is located such that a position thereof is maintained regardless of an operation onto the operation portion, and the second indication is located such that a position thereof is variable in accordance with an operation onto the operation portion.
US10201760B2	System and method for compressing video based on detected intraframe motion A system and method are described below for encoding interactive low-latency video using interframe coding. For example, one embodiment of a computer-implemented method for performing video compression comprises: logically subdividing each of a sequence of images into a plurality of tiles, each of the tiles having a defined position within each of the sequence of images, the defined position remaining the same between successive images; detecting motion within the sequence of images occurring at each of the positions of each of the tiles; and encoding each tile within each image of the sequence of images using a first compression format or a second compression format, wherein the frequency at which a particular tile is encoded according to the first compression format across the sequence of images is based on the detected amount of motion at the position of that tile across the sequence of images.
US10201756B2	Control apparatus, control method, computer-readable recording medium, and game system A social game capable of adding or improving unexpectedness, dramatic impact, and taste when a reward is provided to a player, and hence capable of raising the player's motivation to participate in or continue the game. A unit for storing information related to a game in which multiple players can participate stores a reward providing condition, rewards, and reward box information, and a control unit for accessing information related to the game, performing computation on the game, and displaying images of the game on terminal devices operated by players allocates at least one reward out of the rewards to the reward box, determines whether the reward providing condition is met based on match-up situations or match-up results between players and first game characters in the game, and displays, on the terminal devices, a screen for providing the reward to players based on the determination results.
US10201752B2	System for interactive sports analytics using multi-template alignment and discriminative clustering A system is described for interactively analyzing plays of a sporting event based on real-world positional tracking data. Using positional information regarding the players and/or ball and/or other objects obtained from a tracking system, along with identified event data and contextual information, the system processes a library of plays (e.g., one or more seasons' worth of a league's contests) into a searchable database of plays using multiple alignment templates and discriminative clustering techniques. A user interface is described for interacting with the database in a graphical manner, whereby users can query a graphical depiction of a play and receive the most similar plays from the library, along with statistical information relating to the plays. The user interface further permits the user to modify the query graphically (e.g., moving or exchanging players, ball trajectories, etc.) and obtain updated statistical information for comparison.
US10201747B2	Multilayered ergonomic grip for handheld controllers Disclosed are various embodiments for a multilayered ergonomic handheld controller grip. The multilayered aspect allows for flexibility and functionality in providing the user a moisture wicking, texturized, durable, antimicrobial, cushioned, and re-attachable customized grip for a handheld controller. The removable embodiment allows for customization and optimization to a user's own physical characteristics eliminating standard fit designs and providing unique customization for enhanced user performance.
US10201743B1	Football helmet having improved impact absorption A football helmet is disclosed that includes a shell constructed of fiber reinforced epoxy resin, a liner made from expanded polypropylene, an impact absorbing layer situated between the liner and the shell, and a face guard. The impact absorbing layer is constructed from either expanded polypropylene or a viscoelastic polymer encased in a suitable thin yet resilient and elastic membrane. An optional impact absorbing band is also shown disposed around the inner periphery of the liner and encircling the player's head. The impact absorbing band serves to reduce impact forces occurring from side helmet impact with objects or players.
US10201738B2	Underwater striking bag device and method of using the same An underwater striking bag device includes a bag having an annular upper compartment disposed in an upper section of the bag and receiving air therein, a neck extending through the upper section and communicating with a lower compartment receiving water therein, a removable cap connected to the neck, an air valve connected to the annular upper compartment to provide for filling air into the annular upper compartment, at least one handle connected to the bag for assisting in filling and removal of the water into the lower compartment.
US10201737B2	Curling broom head and removable handle attachment The curling broom head is composed of a fabric section, flexible section, lower body, upper body, and a stem or stem assembly that is used to attach the broom head to the broom handle. The fabric section is a stand-alone piece of fabric that can easily be removed and replaced by the user. The fabric section is wrapped around the flexible section and lower body and is secured into place and ready for game play when the lower body is attached to the upper body. At any time, the curling fabric may be easily replaced by separating the upper and lower bodies, removing the old fabric from the lower body and replacing it with new fabric.The curling broom handle is an elongated member that is attached to the broom head on one end. A removable device(s) is attached or secured to the broom handle at a desired height and provide an easier profile to grip and/or extra surface area to exert downward force. A removable device is attached or secured to the end of the broom handle to provide an increased surface area to exert downward force on the broom handle.
US10201735B2	Heating a sports device A sports device configured to generate thermal energy to warm surfaces. In one implementation, the sports device embodies a lacrosse stick with a shaft and head. The shaft includes a thermal core with a phase change material that can retain and dissipate heat over an extended period of time.
US10201734B2	Golf bag accessory bag A pocket for a golf bag includes a main body defining a storage compartment. The pocket includes a first attachment mechanism movable between an attached state attaching the main body to a first attachment location of the golf bag and a detached state allowing the main body to be separated from the first attachment location. The pocket also includes a second attachment mechanism movable between an attached state attaching the main body to a second attachment location of the golf bag and a detached state allowing the main body to be separated from the second attachment location. The pocket includes a carry mechanism operable to allow the main body to be carried separately from the golf bag when the first attachment mechanism is in the detached state and the second attachment mechanisms is in the detached state.
US10201733B2	Golf club head with structural columns A golf club head having at least one structural column is disclosed herein. A body comprises a face section, a sole section, and a crown or return section, and defines a hollow interior. Each of the structural columns extends from the crown or return section to the sole section within the hollow interior to reduce stresses placed on the face section during impact with a golf ball. The structural columns are all located within 1 inch of a rear surface of the face section measured along a plane normal to the center of the face, and are spaced a distance of 0.500 to 2.00 inch from one another within the hollow interior.
US10201732B2	Ball with domed panels A ball for sports play such as a soccer ball comprises three layers: a standard outer cover layer and a standard inner or bladder layer along with an intermediate layer of panels. These panels have three portions: a portion and extending into recesses formed by stitching together of the outer panels; a middle portion extending on the inside over the stitching; and a third portion which is disposed between the bladder and the middle portion having a size position and extent sufficient to produce elevations in the central areas of exterior panels in the outer cover layer.
US10201721B2	Fire extinguishing device for in-air use A fire-extinguisher device, for aerial use, comprising a bucket which contains two independent but related tanks or cylinders, one for water and one for a foaming agent mixture, along with a chamber in which the extinguishing foam is generated. The device is also equipped with an electronic mechanism to control operation thereof, as well as mechanism for the dispensing of the extinguishing foam that is produced, and which will allow for rapid dropping or spreading over an extended area, as well as providing various discretionary dispensing services.
US10201720B2	Safety line traveller A traveller for safety line for a fall arrest system has a slot extending to the exterior of the traveller and a safety line locating shuttle provided on-board the traveller wherein the safety line locating shuttle is movable relative to the slot along a predetermined path in a direction across the slot. This aids in accurate positioning of the safety line with respect to the traveller. The slot can be defined between opposed slot edges which are movable relative to one another to reconfigure the slot.
US10201719B2	Gantry system for particle beam therapy A particle beam delivery system includes a beam delivery line of charged particle and a gantry body supporting the beam delivery line. The gantry body is rotatably supported by a first support and a second support. The gantry body serves to rotate the beam delivery line about a horizontal axis passing through the first and second supports. The gantry body comprises a cantilevered portion configured to support at least a section of the beam delivery line in a cantilevered manner extended beyond the first and second supports. The second support is supported by a structure which is rotatable about a vertical axis passing through the second support, thereby providing clearance for the cantilevered portion of the gantry body when rotating about the horizontal axis. The gantry body may be rotatable about the horizontal axis in 360 degrees, clockwise and/or counterclockwise. A gantry assembly and a particle beam radiotherapy system comprising a gantry assembly are also provided.
US10201718B2	Method and system for using Cherenkov radiation to monitor beam profiles and radiation therapy A system for providing monitored radiation therapy has a high energy radiation source, apparatus for excluding uncontrolled ambient light, and apparatus for collecting light emitted from a subject. The system has apparatus for spectrally analyzing the collected light, and a processor for determining oxygenation or other metabolic function of tissue within the subject from spectral analysis of the collected light. The system monitors radiation therapy by providing a beam of high energy radiation; collecting Cherenkov and/or photoluminescent light from the subject, the light generated along the beam; spectrally analyzing the light; and determining oxygenation or metabolic function of tissue from the spectral analysis. Beam profile of the system is calibrated by imaging from multiple angles Cherenkov and/or photoluminescent light emitted by a phantom placed in the beam in lieu of a subject, captured images are analyzed to determine beam profile.
US10201715B2	Magnetic nanostimulator and nanosensor array for biological material stimulation and sensing An apparatus includes a substrate and a plurality of biological material stimulators positioned on the substrate. Each biological material stimulator forms a fluctuating magnetic field capable of inducing a current in biological material.
US10201712B2	Telemetry overuse reduction in an implantable device Systems, apparatus, methods and computer-readable storage media facilitating telemetry overuse reduction in an implantable medical device (“IMD”) are provided. In one embodiment, an IMD includes a housing configured to be implanted at least partially within a patient, a memory and circuitry within the housing and a processor that executes executable components stored in the memory. The executable components include: a communication component configured to establish a telemetry connection with an external device to communicate data associated with sensed physiological data or therapy; and an authorization component configured to determine whether the external device is authorized to communicate with the IMD, wherein the communication component is further configured to disable the telemetry connection with the external device and prevent additional communication with the external device for a defined period of time based on a determination that the external device fails to be authorized to communicate with the IMD.
US10201709B2	Depletion block to block nerve communication An example of a system may include a depletion block neural stimulator and a depletion block controller. The depletion block neural stimulator may be configured to deliver a depletion block stimulation to a nerve. The depletion block stimulation may include a series of pulses at a pulse frequency within a range between about 100 Hz to about 1000 Hz. The depletion block controller may be configured to communicate with the depletion block neural stimulator and control the depletion block stimulation. The depletion block controller may be configured to receive a start depletion block signal and respond to the received start depletion block signal by initiating the delivery of the depletion block stimulation to the nerve, and the depletion block controller may be configured to receive a stop depletion block signal and respond to the received stop depletion block signal by terminating the delivery of the depletion block stimulation to the nerve.
US10201706B2	Systems and methods of improving an inflammatory disorder Methods for improving an inflammatory disorder in a subject are provided. Methods include positioning a therapy delivery device on a neural target site that contributes to immune activity of the subject. The therapy delivery device is activated to deliver a therapy signal to the neural target site to improve the subject's inflammatory disorder.
US10201705B2	Erythropoeitin production by electrical stimulation Described herein are methods, devices, and systems for treating human anemia. The methods, devices, and systems generally include monitoring a patient's hemoglobin level and at least one of autonomic balance and inflammatory state to determine the etiology of the anemic state, modulating at least one of a sympathetic or parasympathetic nerve based on the cause of the anemia, monitoring for changes in the patient's cardiac activity and state of inflammation, and hemoglobin level. An external neurostimulation system is describes, and well as a chronic implantable system. A method for treating a patient for anemia in conjunction with a renal denervation ablation catheter is also disclosed.
US10201704B2	Digital communications in an implantable system Presented herein are implantable digital communication techniques for use in implantable systems, such as implantable hearing systems. An implantable system in accordance with embodiments presented herein includes an implantable stimulator module and an implantable secondary module connected to the implantable stimulator module via a wire connection. The implantable secondary module is configured to generate and send a biphasic information signal to the implantable stimulator module via the wire connection. An error detector in the implantable stimulator module is configured to detect when the biphasic information signal includes an error.
US10201700B2	Termination of a shield within an implantable medical lead A shield located within an implantable medical lead may be terminated in various ways at a metal connector. The shield may be terminated by various joints including butt, scarf, lap, or other joints between insulation layers surrounding the lead and an insulation extension. The shield may terminate with a physical and electrical connection to a single metal connector. The shield may terminate with a physical and electrical connection by passing between an overlapping pair of inner and outer metal connectors. The metal connectors may include features such as teeth or threads that penetrate the insulation layers of the lead. The shield may terminate with a physical and electrical connection by exiting a jacket of a lead adjacent to a metal connector and lapping onto the metal connector.
US10201696B2	Universal defibrillation electrode pad assembly for adult and pediatric subjects A defibrillation electrode pad includes an electrode section and a CPR administration section. The electrode section and the CPR administration section are positioned in the defibrillation electrode pad relative to each other such that the CPR administration section is located above a sternum of an adult subject and the electrode section is located in a position appropriate for the administration of a defibrillation shock to the adult subject when the defibrillation electrode pad is oriented in a first orientation and such that the CPR administration section is located above a sternum of a pediatric subject and the electrode section is located in a position appropriate for the administration of a defibrillation shock to the pediatric subject when the defibrillation electrode pad is oriented in a second orientation different from the first orientation.
US10201694B2	Medical catheter control valve A medical catheter control valve includes a valve body defining a fluid channel and a single open-end hole extended across the fluid channel, and a click-on mechanism consisting of a plunger unit with a through hole and a spring member and mounted in the single open-end hole. When click the plunger unit, the plunger unit is shifted to keep the through hole in alignment with the fluid channel for allowing a fluid to pass through the fluid channel. When push back the plunger unit, the through hole is deviated from the fluid channel and the fluid channel is blocked. Thus, the medical catheter control valve can be conveniently controlled with one single hand.
US10201692B2	Solution delivery device and method The present specification discloses a solution delivery device having a container component and a plug component configured for selective engagement with the container component. The container component has an internal cavity including an elongated mixing channel containing a first constituent, and the plug component provides an internal flow path configured for introduction of a second constituent into the mixing channel for mixing with the first constituent. The plug component may be inserted within the container component partially in a first operational mode and fully in a second operational mode. The first constituent may be a drug and the second constituent a diluent, such that the drug may be lyophilized with the device in the first operational mode and reconstituted with the device in the second operational mode. Multiple devices may be employed in tandem for the co-delivery of multiple constituents. The device may be included in a kit or installed within an injector.
US10201691B2	Article comprising a microneedle An article 100 comprising at least one microneedle 160 is provided. The article comprises a first side 112 and a second side 114 opposite the first side. The first side comprises a central cavity portion 120 and a platform portion 130, with at least one microneedle extending therefrom, wherein the platform portion is not coplanar with the central cavity portion. The platform portion substantially surrounds the central cavity portion. The at least one microneedle 160 comprises a body comprising an outer surface 163; a base segment 166 having a base and a first shape; a tip segment 168 having a tip 164 and a second shape, wherein the second shape is distinct from the first shape; a transition plane 167 that delineates the base segment and the tip segment; and a central axis.
US10201690B2	Wound injector apparatus A wound injector apparatus is described. The wound injector includes a clotting factor, an expandable material, a thermal agent, a chamber, and a nozzle. At least one chamber houses the clotting factor, the expandable factor and the thermal agent. Additionally, at least one nozzle is configured to discharge at least one of the clotting factor, the expandable material, and the thermal agent.
US10201687B2	Surgical device with integrated visualization and cauterization Surgical devices with integrated, visualization and cauterization are described herein where such devices include an elongate structure having a central lumen and an expandable space-creating structure having at least one expandable leaflet mounted in the vicinity of the distal end and is configured for placement within a mammalian body proximate to a therapeutic target. Also included is a proximal terminal having an actuator mounted in the vicinity of the proximal end and is configured to remain outside of said body and provide an actuation mechanism for actuating the space-creating structure. Additionally, at least one fluid connector and said central lumen is in fluid communication between an interior of the expandable space-creating structure and the at least one fluid connector.
US10201686B2	Programmable CSF metering shunt An implantable body fluid drainage system includes a metering shunt having a housing with an internal chamber. A movable barrier divides the chamber into a first section and a second section, and the barrier can be displaced by a differential pressure. A first powered inlet valve providing a fill path to the first section of the chamber, and a first powered drain valve providing a drain path from the first section of the chamber. A CSF inlet conduit connects a CSF space to the first powered inlet valve. A CSF outlet conduit connects the first powered outlet valve to a discharge location. A controller opens the first powered inlet valve and close the first powered drain valve to fill the first section to a volume defined by the barrier and chamber geometry and closes the first powered inlet valve and opens the first powered drain valve to discharge the filled volume from the first section through the outlet conduit.
US10201682B2	Systems and methods for anchoring medical devices Some embodiments of a medical device anchor system include an anchor device that secures a medical instrument (such as a catheter or the like) in place relative to a skin penetration point using subcutaneous anchors. In some implementations, the anchor device can be installed using a technique in which the subcutaneous anchors undergo relatively little or no flexing when being inserted through the skin into the subcutaneous region between the skin and underlying muscle tissue which may be occupied by fatty tissue.
US10201677B2	Endotracheal tube comprising pharyngeal suction catheter Provided is an endotracheal tube, which comprises a baffle, an endotracheal tube body and a pharyngeal suction catheter and is integrally formed. The pharyngeal suction catheter is fixedly connected with an outer wall of the endotracheal tube body. One end of the pharyngeal suction catheter is bent to form a front bent portion, a port of the front bent portion is closed and a side wall of the front bent portion is provided with two suction ports. In the case of oral endotracheal intubation, the pharyngeal suction catheter is introduced to the bottom of the pharynx as the endotracheal tube body is inserted into the weasand, and the pharyngeal suction catheter can stay there for a long period of time, enabling high efficiency of removal of pharyngeal secretions, the reduction of discomfort and adsorption injury of the patient, and the reduction of nursing workload.
US10201676B2	Breathable gas supply apparatus A CPAP device for delivering pressurized, humidified breathable gas for a patient includes a flow generator configured to pressurize a flow of breathable gas. The flow generator includes an air outlet and a removable water container configured to humidify the pressurized breathable gas received from the flow generator. The water container includes an air inlet and an air outlet. The CPAP device further includes a first elastomeric face seal configured to sealingly abut against a substantially flat portion of the water container surrounding the water container air inlet, the first elastomeric face seal being located at an intermediate position between the flow generator air outlet and the water container air inlet when the water container is placed into position to pneumatically communicate with the flow generator. In addition, the CPAP device includes a second elastomeric face seal, a portion of which is configured to sealingly abut against a substantially flat external surface portion of the water container surrounding the water container air outlet.
US10201674B2	Systems and methods for intelligent gas source management Therapy gas delivery systems that provide run-time-to-empty information to a user of the system and methods for administering therapeutic gas to a patient. The therapeutic gas delivery system may include a gas pressure sensor attachable to a therapeutic gas source that communicates therapeutic gas pressure data to a therapeutic gas delivery system controller, a gas temperature sensor positioned to measure gas temperature in the therapeutic gas source that communicates therapeutic gas temperature data to the therapeutic gas delivery system controller, at least one flow controller that communicates therapeutic gas flow rate data to the therapeutic gas delivery system controller, at least one flow sensor that communicates flow rate data to the therapeutic gas delivery system controller, and at least one display that communicates run-time-to-empty to a user of the therapeutic gas delivery system. The therapeutic gas delivery system controller of the system includes a processor that executes an algorithm to calculate the run-time-to-empty from the data received from the gas pressure sensor, temperature sensor, flow controller and flow sensor, and directs the result to the display.
US10201673B2	Nebulizer, a control unit for controlling the same and a method of operating a nebulizer There is provided a method of operating a nebulizer, the method comprising controlling an actuator in the nebulizer to operate in a pulsed operation mode; measuring the sound produced by the nebulizer during operation; and using the measurement of the sound as an indication of the performance of the nebulizer. A control unit for a nebulizer that is configured to perform this method is also described.
US10201672B2	Dry powder inhaler and system for drug delivery A breath-powered, dry powder inhaler, a cartridge, and a pulmonary drug delivery system are provided. The dry powder inhaler can be provided with or without a unit dose cartridge for using with the inhaler. The inhaler and/or cartridge can be provided with a drug delivery formulation comprising, for example, a diketopiperazine and an active ingredient, including, peptides and proteins such as insulin, oxyntomodulin and glucagon-like peptide.
US10201666B2	System and method for syringe fluid fill verification and image recognition of power injector system features A fluid injection system and a fluid verification system for confirming that a syringe, containing a fluid for injection, is fully filled with fluid and neither has free space (i.e., air) near the distal end thereof when the syringe is provided in an upright position nor contains air bubbles. Imaging processing techniques and systems are also provided to determine various injection parameters and to verify the type and certain properties of fluid that is present within a syringe.
US10201663B2	Assembly for a drug delivery device An assembly for a drug delivery device is provided, the assembly having an actuator which is configured to perform a setting movement in a proximal direction in order to set a dose of a drug, and which is configured to perform a dispense movement in a distal direction in order to dispense a dose of a drug. The assembly further having a stop mechanism acting after a maximum amount of a drug has been delivered, which is configured to axially constrain the setting movement of the actuator such that the setting of a dose is inhibited, wherein a limited axial movement of the actuator is allowed.
US10201660B2	Controlling the uniformity of PECVD deposition on medical syringes, cartridges, and the like A method and apparatus for plasma modifying a workpiece such as a medical barrel, medical barrel, vial, or blood tube is described. Plasma is provided within the lumen of the workpiece. The plasma is provided under conditions effective for plasma modification of a surface of the workpiece. A magnetic field is provided in at least a portion of the lumen. The magnetic field has an orientation and field strength effective to improve the uniformity of plasma modification of the generally cylindrical interior surface 16 of the generally cylindrical interior surface 16.
US10201659B2	Administration device for mixing an active substance with a dilution liquid An administration device comprises a container and a mixing device for mixing an active substance (in a first chamber) with a dilution liquid (in a second chamber). The container has a membrane seal at one end and is combined with a mixing device for mixing the active substance. The administration device has an injection needle unit with a distal needle portion facing away from the container for piercing the skin, and disposed opposite thereto is a proximal needle portion facing the membrane when the administration device is in the initial position, which is thrust through the membrane into the container in a mixing position. The administration device includes a protective sleeve arranged coaxially about the injection needle, movable from the initial position only in the proximal direction relative to the container. The protective sleeve can be non-rotatably connected to the container in the mixing position and rotated relative to the mixing device to perform mixing.
US10201657B2	Methods for providing sensor site rotation feedback and related infusion devices and systems Infusion systems, infusion devices, and related operating methods are provided. An exemplary method of operating an infusion device to deliver fluid to a body of a user involves identifying a current site location on the body of the user associated with a sensing arrangement providing sensed measurements of a physiological condition in the body of the user at the current site location, determining one or more performance metrics associated with the current site location corresponding to operation of the infusion device to deliver the fluid in response to the sensed measurements, and providing sensor site feedback in a manner that is influenced by the one or more performance metrics. In one or more embodiments, the sensor site feedback includes recommended sensor site locations for rotation or replacement of the sensing arrangement determined based on historical data associated with the user for different sensor site locations.
US10201656B2	Simplified insulin pump for type II diabetics A simplified insulin pump allows type II diabetics to identify routine patterns in their daily lifestyle that provide a generally accurate typical pattern of activity and meals. An infusion regimen can be programmed into the pump that generally correlates with this typical pattern to provide a viable treatment option for a type II diabetic without the need for specific and precise matching of insulin to carbohydrate consumption or activity level.
US10201651B2	Systems and methods for destroying cancer cells in blood An apparatus for destroying cancer cells in blood includes a vessel for accepting a flow of blood of a patient through the vessel, and a sound energy source coupled with the vessel for generating sound energy at a resonant sweep frequency that causes cancer cells, within the flow of blood in the vessel, to act as cavitation nuclei and implode without implosion of other cells not resonant with the resonant sweep frequency. A method for destroying cancer cells in blood includes circulating blood from a patient through a vessel coupled with a sound energy source and exposing the blood, when passing through the vessel, to sound energy at a resonant sweep frequency to make cancer cells therein act as cavitation nuclei and implode without implosion of other cells not resonant with the resonant sweep frequency.
US10201650B2	Apparatus and method for detecting disconnection of an intravascular access device An apparatus and method are disclosed for detecting the disconnection of a vascular access device such as a needle, cannula or catheter from a blood vessel or vascular graft segment. A pair of electrodes is placed in direct contact with fluid or blood in fluid communication with the vascular segment. In one embodiment, the electrodes are incorporated into a pair of connectors connecting arterial and venous catheters to arterial and venous tubes leading to and from an extracorporeal blood flow apparatus. Wires leading from the electrodes to a detecting circuit can be incorporated into a pair of double lumen arterial and venous tubes connecting the blood flow apparatus to the blood vessel or vascular graft. The detecting circuit is configured to provide a low-voltage alternating current signal to the electrodes to measure the electrical resistance between the electrodes, minimizing both the duration and amount of current being delivered. Detection of an increase in electrical resistance between the electrodes exceeding a pre-determined threshold value may be used to indicate a possible disconnection of the vascular access device.
US10201649B2	Carbon dioxide removal system An extracorporeal blood treatment system including a gas exchange module operatively associated with a gas supply unit and optional pump for removing CO2 from blood. The gas exchange module includes a plurality of short conduits that are uniquely configured and arranged in a gas exchange mat to for efficient CO2 diffusion under conditions of low blood flow.
US10201647B2	Medical treatment system and methods using a plurality of fluid lines Improvements in fluid volume measurement systems are disclosed for a pneumatically actuated diaphragm pump in general, and a peritoneal dialysis cycler using a pump cassette in particular. Pump fluid volume measurements are based on pressure measurements in a pump control chamber and a reference chamber in a two-chamber model, with different sections of the apparatus being modeled using a combination of adiabatic, isothermal and polytropic processes. Real time or instantaneous fluid flow measurements in a pump chamber of a diaphragm pump are also disclosed, in this case using a one-chamber ideal gas model and using a high speed processor to obtain and process pump control chamber pressures during fluid flow into or out of the pump chamber. Improved heater control circuitry is also disclosed, to provide added or redundant safety measures, or to reduce current leakage from a heater element during pulse width modulation control of the heater. Improvements are also disclosed in the application of negative pressure during a drain phase in peritoneal dialysis therapy, and to control the amount of intraperitoneal fluid accumulation during a therapy. Improvements in efficiency are also disclosed in the movement of fluid into and out of a two-pump cassette and heater bag of a peritoneal dialysis cycler, and in the synchronization of the operation of two or more pumps in a peritoneal dialysis cycler or other fluid handling devices using a multi-pump arrangement.
US10201645B2	Catheter pump with positioning brace A catheter pump assembly is provided that includes an elongate body assembly, a shaft, and an impeller. The assembly has a proximal end, a distal end and at least one lumen extending therebetween. The shaft is disposed at least partially within the elongate body, e.g., in the at least one lumen, and journaled for rotation. The impeller is coupled with a distal portion of the shaft. The impeller is configured to be rotated to induce flow of blood when the impeller is placed in fluid communication with a source of blood. An inflatable balloon brace is disposed on an outer surface of the catheter pump. The inflatable balloon brace is spaced proximally of the impeller and has a low profile configuration for delivery through the vasculature and an expanded configuration for disposing (e.g., position and/or orienting) the impeller within the source of blood.
US10201643B2	Delivery-and-fluid-storage bridges for use with reduced-pressure systems Systems, methods, and apparatuses are presented that facilitate the provision of reduced pressure to a tissue site by using a delivery-and-fluid-storage bridge, which separates liquids and gases and provides a flow path for reduced pressure. In one instance, a delivery-and-fluid-storage bridge includes a delivery manifold for delivering reduced pressure to a treatment manifold at the tissue site and an absorbent layer proximate the delivery manifold adapted to receive and absorb liquids. The delivery manifold and the absorbent layer are encapsulated in an encapsulating pouch. A first aperture is formed proximate a first longitudinal end of the delivery-and-fluid-storage bridge for fluidly communicating reduced pressure to the delivery manifold from a reduced-pressure source, and a second aperture is formed on a patient-facing side of the delivery-and-fluid-storage bridge. Reduced pressure is transferred to the tissue site via the second aperture. Other systems, apparatuses, and methods are disclosed.
US10201640B2	Ultrafine electrospun fibers of poly-4-hydroxybutyrate and copolymers thereof Methods to produce structures containing ultrafine fibers with average diameters from 10 nm to 10 μm and more preferably from 50 nm to 5 μm, have been developed. These methods produce ultrafine fibers without substantial loss of the polymer's weight average molecular weight. The ultrafine electrospun fibers have an unexpectedly higher degree of molecular orientation, and higher melt temperature than fibers derived by dry spinning. In the preferred embodiment, the polymer comprises 4-hydroxybutyrate. The ultrafine fibers are preferably derived by electrospinning. A solution of the polymer is dissolved in a solvent, pumped through a spinneret, subjected to an electric field, and ultrafine fibers with a high degree of molecular orientation are collected. These structures of ultrafine fibers can be used for a variety of purposes including fabrication of medical devices.
US10201630B2	Aromatherapy apparatus and housing The present invention is an apparatus for employing aromatherapy, binaural sounds, music, vibration, and visual effects for altering a user's emotional state. The apparatus comprises: a shape memory foam pillow, a pair of stereo speakers, an aromatherapy diffuser, a pillowcase comprised of a temperature-regulating fabric, a vibrating device, a strobe light, a canopy, and a housing to integrate and support these components. The user connects a smartphone or other portable digital audio device to the speakers, activates the aromatherapy diffuser, strobe light, and vibrating device, independently or in combination, and then lays his head down on the pillow beneath the open canopy. Ideally, the smartphone or audio device should have a meditation, music, or binaural sound application, which would be tuned to a specific beat frequency, e.g. 10 Hertz. The combined action of essential oil vapors, binaural sounds or music, vibration, and strobe light should alter the user's emotional state towards relaxation, sleepiness, or increased alertness, depending on the essential oils, sounds, vibration, and light patterns employed.
US10201624B2	Triazine based radiopharmaceuticals and radioimaging agents Compounds according to Formula I and Formula II are potent inhibitors of PSMA. Pharmaceutical compositions may include a complex of a radionuclide and a Formula I compound or a Formula II compound. Methods include using the radionuclide complex of a Formula I compound or a Formula II compound for treating or diagnosis of a disease or a condition associated with PSMA activity.
US10201623B2	HSP90-targeted cardiac imaging and therapy The present invention provides new methods for cardiac imaging and related medical applications thereof. In some embodiments, the present invention provides a method for the diagnosis of cardiovascular diseases, conditions, or disorders. In some embodiments, the present invention provides a method for the treatment or prevention of cardiovascular diseases, conditions, or disorders. In some embodiments, the present invention provides methods for monitoring the effect of cancer treatment on the heart, and/or methods for monitoring a cancer treatment regimen. In some embodiments, the present invention provides a method for selecting subjects for a test or treatment. In some embodiments, the present invention provides a method for determining the dosage of a drug. In some embodiments, the present invention provides methods for determining the risk of a cardiovascular disease, for assessing risk of a cardiovascular disease, and/or for determining the risk of heart attack.
US10201622B2	Tumour-targeted theranostic The present inventors have harnessed the targeting of nanoparticles to tumor sites, combined with the tumor site specific elevated MMP-14 activity within one conjugate to simultaneously deliver a vascular disrupting agent (VDA) and a MRI contrast agent to a tumor site. The MMP activatable conjugate of the present invention provides both therapeutic and diagnostic functions—and is referred to as a “theranostic”. The theranostic conjugate of the present invention achieves the benefits of tumor site specificity, VDA delivery and MRI contrast agent delivery in a single theranostic conjugate. Consequently, the present invention provides a cancer “theranostic” which improves therapeutic efficacy while simultaneously reducing dose-limiting systemic toxicities and provides a tool for rapidly and non-invasively identifying tumor location, monitoring drug delivery and pharmacodynamics.
US10201618B2	Alkenyl substituted 2,5-piperazinediones, compositions, and uses thereof Provided herein are compounds of Formula (I), and salts thereof, wherein each instance of RL is independently optionally substituted C6-C40 alkenyl. Further provided are compositions comprising a compound of Formula (I) and an agent. Further provided are methods and kits using the compositions for delivering an agent to a subject or cell and for treating and/or preventing a range of diseases. Further provided are methods of preparing compounds of Formula (I) and precursors thereof.
US10201615B2	Synergistic effects between auristatin-based antibody drug conjugates and inhibitors of the PI3K-AKT mTOR pathway The present invention is directed to methods for treating cancer comprising administering to a subject in need thereof an auristatin-based antibody drug conjugate and an inhibitor of the PI3K-AKT-mTOR pathway.
US10201613B2	Method of creating hydrogels through oxime bond formation A method of creating a hydrogel, comprising the step of condensing first and second functional groups, wherein the first group comprises a molecule or macromolecule of interest containing two or more hydroxylamine or aminooxy groups and the second group comprises a molecule or macromolecule of interest containing two or more aldehyde/ketone/other reactive oxo groups, under conditions such that a hydrogel forms.
US10201612B2	Devices and methods for controlling headspace humidity and oxygen levels A humidity control device for use in maintaining the desired humidity of a closed environment, e.g., a container, while also decreasing headspace oxygen, the device including a water vapor and oxygen permeable pouch, an aqueous salt solution containing humidity controlling salts in combination with salts of ascorbic acid or isomers thereof.
US10201611B2	Pharmaceutical composition comprising estetrol derivatives for use in cancer therapy The present invention relates to a method of treating or preventing estrogen-sensitive tumours in a mammal, said method comprising the administration of a therapeutically effective amount of an estrogenic component to said mammal, wherein the estrogenic component is selected from the group consisting of:substances represented by the following formula in which formula R1, R2, R3, R4 independently are a hydrogen atom, a hydroxyl group or an alkoxy group with 1-5 carbon atoms; precursors capable of liberating a substance according to the aforementioned formula when used in the present method; and mixtures of one or more of the aforementioned substances and/or precursors. The estrogenic component according to the invention does not have undesirable proliferative effects on breast and/or endometrial tissue and displays sufficient estrogenicity to prevent that its administration will lead to hypoestrogenism and/or climacteric complaints.Other aspects of the invention relate to pharmaceutical compositions, drug delivery systems and kits comprising the aforementioned estrogenic component in combination with an estrogen suppressant.
US10201610B2	Interference peptides and use thereof A purified and isolated peptide comprises an amino acid sequence of SEQ ID NOs: 1 to 8. A method is also provided for preventing interaction, e.g. binding, of EN1 with EPRS in a cell by introducing, into the cell, a peptide having a sequence of SEQ ID NOs: 1 to 8, which results in the peptide interacting with EPRS thereby preventing an interaction of EPRS with EN1. Apoptosis can be induced in a cell expressing either or both of EN1 and EN2, by introducing into the cell, a peptide of SEQ ID NOs: 1 to 8.
US10201608B2	Polynucleotides encoding humanized anti-CD40 antibodies The present disclosure relates to anti-CD40 antibodies, such as humanized anti-CD40 antibodies, that may be used in various therapeutic, prophylactic and diagnostic methods. The antibodies generally block the ability of CD40 to bind CD154 and do so without activating the cell expressing CD40 (e.g., a B cell). The present antibodies or fragments thereof may be used to reduce complications associated with organ or tissue transplantation.
US10201607B2	Antibodies binding AXL The present invention relates to anti-AXL antibodies, immunoconjugates, compositions and method of treatment of cancer with such anti-AXL antibodies, immunoconjugates, or compositions.
US10201601B2	Compositions and methods for increasing immunogenicity of glycoprotein vaccines The present invention relates to the microbial immunogens engineered to bear α-gal epitope(s) for induction of potent humoral and cellular immune responses when administered to subjects having anti-Gal antibodies. In one embodiment, the present invention provides compositions and methods for propagating influenza virus in human, ape, Old World monkey or bird cells that have been engineered to express an α1,3galactosyltransferase (α 1,3GT) gene to produce virions bearing hemagglutinin molecules containing α-gal epitopes, to increase the immunogenicity of the influenza virus. In another embodiment, the present invention provides fusion proteins between influenza virus hemagglutinin and a microbial peptide or protein of interest, and enzymatic processing of this fusion protein to carry α-gal epitopes, to increase the immunogenicity of the microbial peptide or protein of interest.
US10201600B2	Process for preparing an attenuated tetravalent dengue vaccine The present invention refers to a process for preparing an attenuated tetravalent dengue vaccine and its product. The present invention also refers to a process for preparing a tetravalent dengue vaccine for administration to a subject, to a method for inducing an immune response to virus dengue serotype 1, 2, 3 and 4 in a patient and to a tetravalent dengue vaccine kit.
US10201599B2	Immunogenic compositions comprising Lawsonia intracellularis The present invention provides combination vaccines that comprise an immunological agent effective for reducing the incidence of or lessening the severity of PPE caused by L. intracellularis, and one or more immunological active components effective in treatment and/or prophylaxis of at least one further disease-causing organism for swine. Moreover, the present invention also relates to a kit that comprises an immunological agent effective for reducing the incidence of or lessening the severity of PPE caused by L. intracellularis, and one or more immunological active components effective in treatment and/or prophylaxis of at least one further disease-causing organism for swine.
US10201598B2	Synthetic immunogens for prophylaxis or treatment of tuberculosis Compositions comprising a nucleic acid molecule that encodes TB esat-6 proteins are disclosed. Methods of inducing an immune response against TB an individual are disclosed. Method of treating an individual who has been diagnosed with TB are disclosed. Method of preventing TB infection in an individual are disclosed.
US10201595B2	C1-INH compositions and methods for the prevention and treatment of disorders associated with C1 esterase inhibitor deficiency Compositions and methods for the treatment and/or prevention of disorders associated with C1 esterase inhibitor deficiency are disclosed.
US10201593B2	Method of treating gluten intolerance by means of new S8/S53 endopetidases from the actinomycete Actinoallomurus The invention relates to a new family of proteolytic enxymes having the ability to hydrolize at a pH between 3 and 8 gluten olygopeptides which are resistant to cleavage by gastric and pancreatic enzymes and whose presence in the intestinal lumen results in toxic effects. The enzymes have been identified as endopeptidases of the S8/S53 family and are produced by an Actinoallomurus strain.The object of the invention includes also methods for producing enzymes composition comprising the endopeptidases by cultivation of native Actinoallomurus strains, mutants thereof, or recombinant host cells comprising nucleic acids codifying for the endopeptidases. Said nucleic acids constitute a further object of the invention.The enzyme compositions comprising at least one endopeptidase of the invention are useful for the treatment and/or prevention of celiac sprue, dermatitis herpetiformis and any other disorder associated with gluten intolerance as ingredients of pharmaceutical formulations or as additives of foods and drinks.
US10201588B2	Materials and methods of treating dyslipidemia Described herein are materials and methods for treating dyslipidemia in a mammalian subject in need thereof comprising administering a growth hormone-releasing hormone (GHRH) antagonist or variant thereof to the subject.
US10201586B2	TFPI inhibitors and methods of use The invention provides peptides that bind Tissue Factor Pathway Inhibitor (TFPI), including TFPI-inhibitory peptides, and compositions thereof. The peptides may be used to inhibit a TFPI, enhance thrombin formation in a clotting factor-deficient subject, increase blood clot formation in a subject, treat a blood coagulation disorder in a subject, purify TFPI, an identify a TFPI-binding compound.
US10201581B2	Composition for cooling skin comprising phellodendron bark extract, method of preparing the same, topical composition comprising the same and dermatologically acceptable carrier, and method of cooling skin by applying the same Provided are a composition for cooling skin comprising a Phellodendron bark extract, a method of preparing the composition, a skin-improving product comprising the composition and a method of cooling skin by applying the composition to a skin of a subject, wherein the skin needs cooling. The composition prevents a burning sensation in the skin and under the skin and reduces heat generated under the skin and on the skin. The composition includes a Phellodendron bark extract as a main ingredient and further includes an extract of one or more selected from the group consisting of Anemarrhena asphodeloides, Scutellaria baicalensis, Paeonia lactiflora, Dictamnus dasycarpus, Alumen, Dryobalanops aromatic and Mentha arvensis.
US10201579B2	Compositions for reducing environmental sensitivity and regulating immune function The present invention is directed to compositions for improving immune function and sensitivities to the natural and manmade environment that include ingredients from natural sources. It is further directed to methods of administering the compositions and kits containing the compositions. In a composition aspect, the composition is for regulating immune function and non-immune related sensitivities. It consists essentially of: 2 weight percent to 95 weight percent Psoralea; 2 weight percent to 95 weight percent Scutellaria; and 2 weight percent to 95 weight percent Xanthium. The Scutellaria portion may be replaced by Gardenia (in equal measure), or by a mixture of Scutellaria and Gardenia.
US10201578B2	Pharmaceutical composition or health food comprising Lonicera caerulea var. edulis fruit extracts as active ingredients for preventing or improving ischemic cerebrovascular diseases The present invention relates to a composition containing a fruit extract of Lonicera caerulea L. var. edulis as an active ingredient for the prevention and treatment of ischemic cerebrovascular disease. The fruit extract of Lonicera caerulea L. var. edulis according to the present invention has a nerve cell-protecting effect, thereby remarkably reducing neurobehavioral impairments and infarct volume due to ischemic cerebrovascular disease. Therefore, it can be provided as a pharmaceutical composition for the prevention or treatment of ischemic cerebrovascular disease, and as a health food for the prevention or improvement of ischemic cerebrovascular disease.
US10201576B2	Herbal composition for vaginal treatment The present invention discloses a herbal formulation comprising therapeutic effective amount of plant extract of Woodfordia Floribunda; therapeutic effective amount of plant extract of Centella Asiatica; and an effective amount of at least one pharmaceutically acceptable excipient.
US10201575B2	Oncolytic HSV vector The present invention provides a recombinant oncolytic Herpes Simplex Virus (oHSV) comprising a non-HSV ligand specific for a molecule (protein, lipid, or carbohydrate determinant) present on the surface of a cell (such as a cancer cell) and a plurality of copies of one or more microRNA target sequences inserted into one or more HSV gene loci, preferably one or more HSV gene(s) required for replication of HSV in normal (i.e., non-cancerous) cells, and a deletion of the internal repeat (joint) region in the HSV genome comprising one copy of the ICP0, ICP34.5, LAT, and ICP4 genes and the ICP47 promoter. The invention further provides stocks and pharmaceutical compositions comprising the inventive oHSV and methods for killing tumor cells employing the inventive oHSV.
US10201574B1	Methods of microbial treatment of poultry Disclosed are methods of administering one or more Bacillus strains to poultry. The Bacillus strains improve bacterial homeostasis in the gastrointestinal tract by inhibiting bacterial pathogens such as E. coli and Clostridium. Administering the Bacillus strains also improves performance such as weight gain and feed conversion. Useful combinations of Bacillus strains and methods of using one or more Bacillus strains are also provided.
US10201565B2	Gas conditioning A method for reducing or preventing mesothelial cell damage by mixing a carrier gas and between 1 volume percent and 29 volume percent of nitrous oxide gas (N2O) to form a medicament and applying the medicament during surgery. The method can be used for prevention of adhesion formation, pain reduction, reducing or preventing acute inflammation, reducing or preventing CO2 resorbtion or reducing tumor cell implantation upon surgery.
US10201564B2	Methods of using inhaled nitric oxide gas for treatment of acute respiratory distress syndrome in children The present invention provides a treatment of acute respiratory distress syndrome (ARDS) in children using dosing of nitric oxide at low concentrations, such as less than 10 ppm.
US10201562B2	Polymeric treatment compositions Compositions are described comprising a polymer; a non-physiological pH solution; and a visualization agent; wherein the polymer is soluble in the non-physiological pH solution and insoluble at a physiological pH. Methods of forming the solutions and polymers are disclosed as well as methods of therapeutic use.
US10201561B2	Antiviral fiber assembly with cellulose sulfate An object of the present invention is to provide an antiviral fiber assembly in which an antiviral agent is retained with chemical stability over a long period of time, and which is gentle to the human body. A further object of the present invention is to provide a fiber assembly with cellulose sulfate that can exhibit sufficient antiviral activity over a long period of time. Further, another object of the present invention is to provide a textile product obtained using such a fiber assembly.The present invention provides a fiber assembly with cellulose sulfate, wherein the hyaluronidase inhibitory activity is 50% or higher; and a process for producing a fiber assembly with cellulose sulfate, including treating a fiber assembly with an aqueous cellulose sulfate solution and drying, then treating the same with a pH buffer solution and drying.
US10201555B2	Methods and materials for reducing the risk of infections This document relates to methods and materials for reducing the risk of infection after a shoulder surgery or medical procedure. For example, this document relates to methods and materials for using a topical composition containing clindamycin or erythromycin to reduce the risk of or to prevent infection associated with shoulder surgeries or medical procedures.
US10201554B2	Esters of 2-deoxy-monosacharides with anti proliferative activity Compounds and methods of using the same to inhibit glycolysis and treat cancer and other diseases are disclosed.
US10201551B2	Nutritional intervention for improving muscular function and strength The present invention provides a composition comprising HMB and Vitamin D. Methods of administering HMB and Vitamin D to an animal are also described. Vitamin D and HMB are administered to increase muscle mass, strength, and functionality. The combination of Vitamin D and HMB together has a synergistic effect, which results in a surprising and unexpected level of improvement in muscle mass, strength and functionality.
US10201548B2	Methods for treating ocular inflammatory diseases A method of treating blepharitis includes administering to the affected eye of a subject an effective amount of an active ingredient in an ophthalmically acceptable vehicle for a sufficient period of time to treat blepharitis. The active ingredient consists essentially of a glucocorticoid in an ophthalmically acceptable vehicle that includes an aqueous polymer suspension that when mixed with tear fluid provides a sustained release of said active ingredient. The aqueous polymer suspension includes a carboxyl-containing polymer having less than about 5% by weight cross-linking agent and has a viscosity in a range from about 1,000 to about 30,000 centipoises. A kit includes: (a) a composition comprising about 0.1% by weight dexamethasone in this ophthalmically acceptable vehicle and (b) instructions for using the composition of (a) for the treatment of blepharitis.
US10201544B2	Method of synthesising ADCs using affinity resins This invention relates to a solid phase method of synthesizing biomolecule-drug conjugates. In particular, this invention relates to a solid phase method of synthesizing antibody-drug conjugates (ADCs). This invention also relates to intermediate methods of producing immobilized, chemically modified biomolecules, e.g. antibodies. The invention also relates to various uses of capture resins and to biomolecule-drug conjugates, intermediate products and compositions prepared by the methods of the invention.
US10201535B2	Pharmaceutical compositions comprising 7-(1H-imidazol-4-ylmethyl)-5,6,7,8-tetrahydro-quinoline for treating skin diseases and conditions The present invention relates to a method for treating skin diseases and skin conditions in a patient in need thereof which comprises of administering a therapeutically effective amount of a pharmaceutical composition comprising a therapeutically effective amount of 7-(1H-imidazol-4-ylmethyl)-5,6,7,8-tetrahydro-quinoline, or its individual enantiomers or the tautomers thereof, or a pharmaceutically acceptable salt thereof.
US10201534B2	Ophthalmic composition Provided herein is an ophthalmic composition. In some embodiments, the ophthalmic composition includes a low concentration of an ophthalmic agent for treatment of an ophthalmic disorder or condition; and an ophthalmically acceptable carrier, wherein the ophthalmic agent is distributed with substantial uniformity throughout the ophthalmically acceptable carrier. Further disclosed herein include an ophthalmic composition including a low concentration of an ophthalmic agent and deuterated water. Also disclosed herein are methods of arresting or preventing myopia development by administering to an eye of an individual in need thereof an effective amount of an ophthalmic composition as described herein.
US10201528B2	Method of treating multiple sclerosis The invention provides methods for treating multiple sclerosis by administering biotin. The invention also provides methods for treating sequelae after multiple sclerosis attacks by administering biotin.
US10201525B2	Tetrazole-substituted arylamides as PX2 and PX2/3 antagonists A method of antagonizing P2X3 and/or P2X2/3 receptors or treating a disease misregulation of P2X3 and/or P2X2/3 receptors treating a patient with a compound of formula I wherein R1, R2, R3, R4, R5 and R6 are as defined herein, or a pharmaceutically acceptable salt thereof. wherein, R1 is optionally substituted tetrazolyl, R2 is optionally substituted phenyl, optionally substituted pyridinyl or optionally substituted thienyl, and R3, R4, R5 and R6 are as defined herein. Also provided are methods of using the compounds for treating diseases associated with the P2X3 and/or a P2X2/3 receptor antagonist and methods of making the compounds.
US10201524B2	Antifungal agents The invention provides a pyrrole compound, which compound is (a) 2-(1,5-dimethyl-3-phenyl-1H-pyrrol-2-yl)-N-(4-(4-(5-fluoropyrimidin-2-yl)piperazin-1-yl)phenyl)-2-oxoacetamide or a deuterated derivative thereof, or (b) 2-(1,5-dimethyl-3-phenyl-1H-pyrrol-2-yl)-N-(4-(4-(5-fluoropyrimidin-2-yl)piperazin-1-yl)-3-hydroxyphenyl)-2-oxoacetamide or a deuterated derivative thereof, or (c) a prodrug of compound (a) or a prodrug of compound (b), or a pharmaceutically acceptable salt or agriculturally acceptable salt of (a), (b) or (c). Also provided are combinations and compositions comprising the compound and known antifungal agents. The invention also relates to the therapeutic use of a compound of the invention in prevention or treatment of fungal diseases. It also relates to the use of: 2-(1,5-dimethyl-3-phenyl-1H-pyrrol-2-yl)-N-(4-(4-(5-fluoropyrimidin-2-yl)piperazin-1-yl)phenyl)-2-oxoacetamide or an agriculturally acceptable salt thereof, or 2-(1,5-dimethyl-3-phenyl-1H-pyrrol-2-yl)-N-(4-(4-(5-fluoropyrimidin-2-yl)piperazin-1-yl)-3-hydroxyphenyl)-2-oxoacetamide or an agriculturally acceptable salt thereof, as an agricultural fungicide.
US10201521B2	Use of substituted hexitols including dianhydrogalactitol and analogs to treat neoplastic disease and cancer stem and cancer stem cells including glioblastoma multiforme and medulloblastoma The use of dianhydrogalactitol provides a novel therapeutic modality for the treatment of glioblastoma multiforme and medulloblastoma. Dianhydrogalactitol acts as an alkylating agent on DNA that creates N7 methylation. Dianhydrogalactitol is effective in suppressing the growth of cancer stem cells and is active against tumors that are refractory to temozolomide; the drug acts independently of the MGMT repair mechanism.
US10201519B2	Stabilized pediatric suspension of carisbamate The present invention provides a stabilized pharmaceutical suspension of carisbamate for pediatric and adult use. More particularly, the suspension is stabilized with hypromellose (HFMC) to prevent crystal growth of the suspended particles and to prevent re-crystallization of the drug product with change in polymorphic form.
US10201515B2	Use of derivatives of polyunsaturated fatty acids as medicaments Use of polyunsaturated fatty acid derivatives as medicaments or functional foods. The present invention relates to the use of 1,2-fatty acid derivatives in the treatment or prevention of common diseases whose etiology is based on alterations (of any type) of the cell membrane lipids, for example, changes in levels, in the composition or in the structure of these lipids. In addition, for diseases in which the regulation of lipid composition and of the structure of the membranes (or proteins that interact with membranes) causes the reversion of pathological state.
US10201512B2	Autoimmune disorder treatment using RXR agonists The present specification provides RXR agonist compounds, compositions comprising such RXR agonists, and methods using such compounds and compositions to treat an autoimmune disorder, inflammation associated with an autoimmune disorder and/or a transplant rejection as well as use of such RXR agonists to manufacture a medicament and use of such compounds and compositions to treat an autoimmune disorder, inflammation associated with an autoimmune disorder and/or a transplant rejection.
US10201503B1	Precision pharmaceutical 3D printing device Provided herein are devices and systems for depositing a material or manufacturing a product, such as a pharmaceutical dosage form, by additive manufacturing. Further provided are methods of using the devices and systems, as well as methods of manufacturing a product, such as a pharmaceutical dosage form, by additive manufacturing. In certain embodiments, the device includes a material supply system configured to melt an pressurized a material, a pressure sensor configured to detect a pressure of the material within the device, and a control switch comprising a sealing needle operable in an open position and closed position. The sealing needle extends through a feed channel containing the material and includes a taper end, wherein the tapered end of the sealing needle engages a tapered inner surface of a nozzle to inhibit flow of the material through the nozzle when the sealing needle is in the closed position.
US10201501B2	Mixed metal compounds used as antacids There is provided use of a mixed metal compound in the manufacture of medicament for neutralizing or buffering stomach acid, wherein the mixed metal compound contains at least one trivalent metal selected from iron (III) and aluminum and at least one divalent metal selected from of magnesium, iron, zinc, calcium, lanthanum and cerium, wherein (A) the mixed metal compound is of formula (I): MII1-aMIIIaObAn−c.zH2O (I) where MII is the at least one bivalent metal; MIII is the at least one trivalent metal; An− at least one n-valent anion; 2+a=2b+Σcn and Σcn<0.9a, and z is 2 or less, and/or (B) the mixed metal compound is provided in the form of a granular material comprising (i) at least 50% by weight, based on the weight of the granular material, of the mixed metal compound (ii) from 3 to 12% by weight, based on the weight of the granular material, of non-chemically bound water, and (iii) no greater than 47% by weight based on the weight of the granular material of excipient.
US10201497B2	Treatment of migraine headaches with presynaptic neurotoxin The present invention provides a method for treating a patient for migraine headache, including symptoms associated with migraine head ache, such as migraine associated vertigo, which comprises administering to the patient a therapeutically effective amount of an invertebrate presynaptic neurotoxin, e.g. Botulinum toxin in a pharmaceutically safe form.
US10201493B2	Method of reducing oral biofilm An oral composition having a biofilm formation inhibitory action is provided. An oral composition, comprising a plant extract which is a hot water extract of Japanese mustard spinach, potherb mustard, mibuna, hot radish, cress, ostrich fern, Japanese angelica tree, or ice plant.
US10201483B2	Dye composition in cream form comprising at least one oil and little or no solid fatty alcohol, dyeing process and suitable device The present invention relates to a composition for dyeing human keratin fibres, such as the hair, which is free of oxidizing agent other than atmospheric oxygen and which is in cream form, comprising: (a) at least one oxidation dye precursor; (b) at least one ionic surfactant; (c) at least one oil; (d) optionally at least one solid fatty alcohol in a content of not more than 0.5% by weight relative to the weight of the composition; (e) at least one thickening polymer. The invention also relates to a process for dyeing human keratin fibres, in which this composition is applied to the said fibres, in the presence of at least one oxidizing agent other than atmospheric oxygen, and also to a multi-compartment device that is suitable for performing this process.
US10201481B2	Personal care compositions and methods of making same Personal care compositions include a zinc-containing material and/or a pyrithione material, and are substantially free of a structurant. Methods of making the personal care composition and for improving skin health are also provided herein.
US10201476B2	Pressure-regulating vial adaptors According to some embodiments of the present disclosure, an adaptor configured to couple with a sealed vial can include a connector interface. The adaptor can include one or more access channels (e.g., passages). In some cases the one or more access channels are in fluid communication with the connector interface. The adaptor can include a piercing member. The piercing member can include a regulator channel. The adaptor can include a regulator assembly. The regulator assembly can include a first regulator inlet. In some cases, the regulator includes a second regulator inlet. One or more of the first and second regulator inlets can include a filter configured to filter fluid passing into and/or out of the respective regulator inlets. One or more valves can be positioned between the first and/or second regulator inlets and the piercing member.
US10201475B2	Container closure system The invention relates to a pharmaceutical product or container closure system containing an overpouch with an intransparent first foil and a transparent second foil, a transparent primary container for holding a transparent liquid, e.g., a pharmaceutical formulation, wherein the transparent primary container is packed within the overpouch and labeled with at least one label and wherein the at least one label acts as a light absorbing segment having a reflection RL for light in the range of about 350 nm to about 800 nm and an inner surface of the intransparent first foil of the overpouch acts as a light reflecting background having a reflection RF for light in the direction of the primary container in the range of about 350 nm to about 800 nm with RF≠RL. By the transparent second foil and the inventive reflection properties it is achieved that the at least one label on the primary container is visible and readable. Additionally, visual inspection of the content of the transparent primary container is possible. A good contrast is achieved to enhance machine and human readability.
US10201473B2	Respiratory treatment device A respiratory treatment device can include a removable cup portion. The cup portion can be removably couple to a weighted head. The weighted head can be connected to a first end of a shaft. A second end of the shaft can be connected to a handle. A center of gravity of the device along a length of the device can be modified by increasing or decreasing the weight of the handle and/or of the weighted head. A user of the treatment device can tap a patient with the cup portion of the device. The weighted head can increase deflection in shaft of the device during use.
US10201457B2	Wound packing device with nanotextured surface Embodiments of the invention include wound packing devices and methods of making and using the same. In an embodiment, the invention includes a wound packing device including a plurality of spacing elements comprising a nanotextured surface. The wound packing device can also include a connector connecting the plurality of spacing elements to one another. Other embodiments are also included herein.
US10201455B2	System for inner ear drug delivery via trans-round window membrane injection The present disclosure discussed a handpiece for trans-canal delivery of a therapeutic substance to the inner ear. The handpiece can be inserted into the middle ear via a surgical tympanotomy approach. The handpiece can enable a controlled injection of a therapeutic substance directly through the round window membrane and into the inner ear. The direct delivery of the therapeutic substance to the inner ear can enable the delivery of a precise amount of therapeutic substance into the inner ear. Because the therapeutic substance is delivery directly to the inner ear the delivery of the therapeutic substance is not subject to limitations on molecule size and inconsistent diffusion rates that are present when therapeutic substances are diffused across the round window membrane.
US10201453B2	Ophthalmological apparatus for the breakdown of eye tissue An ophthalmological apparatus includes a handle for manually holding and applying the ophthalmological apparatus, fastening abilities for fixing the ophthalmological apparatus at an eye, a light source, and a light projector for the focused projection of light pulses for punctiform tissue breakdown at a focal point in the interior of the eye tissue. The ophthalmological apparatus also includes a movement driver for moving the light projector. The movement of the light projector and therefore that of the focal point with the assistance of the movement driver permits a dimensioning of the optical projection system of the light projector which is substantially smaller than in the case of an ophthalmological apparatus where the focal point is moved exclusively by an optical projection system.
US10201444B2	Method for loading a stent into a delivery system Methods for assembling a stent delivery system are provided, as well as the stent delivery assemblies and devices formed by such methods. Also provided is a method for loading a stent into a delivery system.
US10201442B2	Valve loader method, system, and apparatus A valve loading system is provided that uses a valve loader to transfer a valve or other medical device from a storage cartridge into a deployment catheter. The valve or other medical device can be implanted or positioned within a patient using the catheter after the valve or other medical device has been compressed and loaded into the catheter using the valve loader. The process then can be repeated by using the valve loading system to load or introduce another valve or other medical device into the catheter.
US10201438B2	Magnetic prosthetic implants and methods thereof Prosthetic implant devices and related methods are provided. The prosthetic implant devices includes an internal component and an external component. The internal component has an implant portion associated with one or more rare earth magnets. The internal component being of a size and shape suitable for surgical implantation into the residual limb of the amputee. The implant portion being of a size and shape suitable for surgical implantation into a bone within the residual limb of the amputee. The one or more rare earth magnets generating at least one magnetic field. The external component having a prosthetic connection associated with a magnetic element. The magnet element being in adaptable magnetic association with the at least one magnetic field generated by the one or more rare earth magnets.
US10201436B2	Joint mechanism control device A present invention provides a joint power control device. A joint interlock displacement part (52) of a power transmission movable mechanism (53), which is comprising of a moving pulley (51) and the like, is connected to a joint mechanism (5) disposed between a first member (2) and a second member (3). A flexible lengthy member (32), which is one of two flexible lengthy members (32, 32) extending from the power transmission movable mechanism (53), is connected to a control mechanism (54) that controls the movement of the flexible lengthy member (32). Further, an elastic structure (31) is engaged with the other flexible lengthy member (32).
US10201433B2	System and method for correcting scoliosis In described embodiments, an implant has an outer perimeter. The implant includes a top surface extending generally in a first plane and a bottom surface extending in a second plane. The second plane extends obliquely with respect to the first plane. The first plane intersects the second plane outside the outer perimeter of the implant. A medial surface extends between the top surface and the bottom surface proximate to the intersection of the first plane and the second plane. A lateral surface extends between the top surface and the bottom surface distal from the intersection of the first plane and the second plane. An anterior surface extends a first distance between the top surface and the bottom surface between the medial surface and the lateral surface. A posterior surface extends a second distance between the top surface and the bottom surface between the medial surface and the lateral surface. The second distance is greater than the first distance.
US10201432B2	Vertebral body replacement device and method for use to maintain a space between two vertebral bodies within a spine A vertebral body replacement device includes a body member and a central rod member having two threaded portions and configured to be operatively associated with the body member. The device also includes a first end member and a second end member with the end members configured to threadingly engage the threaded portions of the central rod member. The body member and the two end members are further constructed to inhibit rotational movement of the two end members when the device is positioned within a space within a spine as the two end members will engage the adjacent respective vertebral bodies following rotational actuation of the central rod member causing the end members to move in an axial direction relative to the body member, thereby allowing the two end members to apply a force to the two vertebral bodies. A surgical instrument and method for using the device are also disclosed.
US10201430B2	Releasable threaded connection for modular implants An orthopedic prosthesis assembly includes a first prosthetic component, a second prosthetic component, and a fastener. The first prosthetic component includes a threaded bore. The second prosthetic component includes an opening and a threaded inner wall that extends inwardly from the opening. The fastener includes a first axial section having a first plurality of threads engaged with the threaded inner wall the second prosthetic component, and a second axial section having a second plurality of threads engaged with the threaded bore of the first prosthetic component to secure the first prosthetic component to the second prosthetic component.
US10201428B2	Orthopaedic surgical instrument system and method for protecting a femoral stem taper An orthopedic hip prosthesis system is disclosed. The orthopedic hip prosthesis system comprises a femoral head component configured to articulate with a natural or prosthetic acetabulum of a patient, the femoral head component having a tapered bore formed therein, a femoral stem component having a tapered trunnion configured to be received in the tapered bore of the femoral head component, and a shell positioned over the tapered trunnion of the femoral stem component. The shell includes a frame extending over the tapered trunnion, and a protective coating applied to the frame and the tapered trunnion. A method of performing an orthopedic surgery is also disclosed.
US10201427B2	Integrated implant An implant having an integrated cutting broach and/or cutting burr. The integrated implant may be inserted without requiring separate steps for drilling and broaching bone. The integrated implant assembly may include an integrated implant, a flexible sheath, a delivery rod, and a delivery pin. The implant may have a core which may have any of a variety of cross-sectional geometries. A method for fusing bone may involve inserting the implant laterally through the ilium, through the sacral-iliac joint, and into the sacrum.
US10201426B2	Prosthetic implant support structure A prosthetic system that includes a prosthetic implant and a support structure secured to an inner surface of the cavity in the end of the bone is disclosed. The support structure defines a channel that extends through the length of the support structure. The prosthetic implant is received in the channel, and a portion of the prosthetic implant is secured to an inner surface of the channel by an adhesive. The stem of the prosthesis beyond the channel may be cemented or uncemented. The support structure may have an approximately funnel shape. The support structure may be a hollow porous cylindrical sleeve. The support structure may comprise a pair of partially hemispherical components arranged in spaced apart relationship thereby defining a channel between the pair of components. The support structure may comprise a plurality of pedestals secured to the inner surface of the cavity of the bone.
US10201424B2	Device and method for improving the function of a heart valve A device for improving the function of a heart valve has a first and a second shape. The device comprises two contact points, and the device in the first shape exhibits a distance between the two contact points essentially corresponding to a distance between two commissures of the heart valve and the device in the second shape exhibits an increased distance between the contact points. The device is in the first shape arranged for insertion to the heart valve to establish a contact between the contact points and the commissures. The device is transferable from the first shape to the second shape, and the device is in the second shape arranged for extending in abutment with valve tissue throughout a cycle of heart action. The device may change the shape of the heart valve by stretching it between the commissures for improving the ability of the heart valve to close.
US10201420B2	Preparation methods for transcatheter heart valve delivery systems A delivery device for a collapsible prosthetic heart valve includes a support shaft around which a compartment is defined, an inner shaft extending through the support shaft and adapted to slide relative to the support shaft along a longitudinal axis thereof, the inner shaft having a lumen therethrough, and a distal sheath operatively connected at a distal end to the inner shaft and slidable therewith. The compartment may receive the valve in an assembled condition, and may be selectively covered and uncovered by the distal sheath. A first flow path may provide flow communication between the lumen of the inner shaft and the compartment.
US10201418B2	Valve replacement devices, delivery device for a valve replacement device and method of production of a valve replacement device A device for heart valve replacement comprises a valve component having at least two valve leaflets preferably made of pericardium tissue. Each valve leaflet includes at least two tabs. The device further includes a stent component configured to be radially compressible into a compressed state and expandable into a functional state. The stent component comprises a first end, a second end and at least one intermediate section arranged between said first and said second end. The intermediate section has at least two commissural posts generally aligned parallel to an axis spanning from the first end to the second end. The commissural posts are formed in the shape of a wishbone.
US10201416B2	Replacement heart valve implant with invertible leaflets A locking mechanism for a medical implant may include a buckle member, a post member axially translatable with respect to the buckle member, the post member including a receiving portion proximate a proximal end of the post member, a distal end, a laterally-arched central body portion extending between the receiving portion and the distal end, and a cantilevered leg extending proximally from the distal end, and an actuator element including a proximal shaft portion and a distal engagement portion, the distal engagement portion being configured to releasably engage the receiving portion of the post member. The proximal shaft portion may be pivotable with respect to the distal engagement portion.
US10201414B2	Introducer for a side branch device An introduction arrangement for a fenestrated or branched stent graft (13) intended for deployment into the lumen of a vessel having a blind vessel extending from it. The introducer (1) has a distal end intended to remain outside a patient in use and a proximal end with a nose cone dilator (11) and an arrangement to retain the branched stent graft distally of the nose cone dilator. A sheath (15) on the introducer extends over the branched stent graft to the nose cone dilator. An indwelling catheter (21) extends from the distal end of the introducer and enters the fenestration or side arm and through to the nose cone dilator, the indwelling catheter has a guide wire (29) extending through it. The guide wire can be extended beyond the nose cone dilator in use before the sheath is withdrawn from the branched stent graft so that it can be snared from the contra-lateral artery.
US10201409B2	Dental appliance having ornamental design A dental appliance having an integrally formed reservoir and/or an ornamental design integrated thereon. The ornamental design can be selected or customized by a patient. The design can be created by directing energy to the dental appliance to alter a material property of at least a portion of the appliance to create the design. Alternatively, a groove or recess can be formed on a surface of the appliance to either mechanically retain an ornamental design or the groove or recess can be filled with ink to form the design. The appliance, including the integrally formed reservoir, can be formed using direct fabrication techniques.
US10201407B2	Device and method for facilitating tooth contact adjustment using a pressure device A structure and method of visualizing and evaluating areas of tooth contact between upper and lower teeth when the upper and lower arches of a mouth are in a closed or occluded condition. The method includes performing a plurality of readings of tooth contacts, by a pressure sensing device, during a period of time and determining sensing properties of the tooth contacts based on the plurality of readings, wherein the sensing properties include one or more of: sequence of a first tooth contact relative to at least a second tooth contact, and pressure magnitude of the first tooth contact.
US10201404B2	Implant for dental prostheses An implant for dental prostheses includes an endosseous portion and a stump. The endosseous portion includes a crown margin configured to be opposed to a corresponding crown margin of the stump. At least one of the crown margins is conical or however has a different taper with respect to the opposed crown margin so that, once the stump has been coupled to the endosseous portion, the contact and interference surface between the crown margins is a reduced annular surface.
US10201403B2	Bracket, orthodontic system with the bracket and an orthodontic method A bracket including a main body part and a covering part. The main body part includes a first surface portion and a first bottom face portion. The first surface portion is provided with a first groove, which divides the first surface portion into first and second ends. The first end has a surface with a first protruding portion having a smooth curved surface. The covering part includes a second surface portion and a second bottom face portion, the second bottom face portion matches with the surface of the second end, and the second surface portion has a smooth curved surface matching the surface of the first protruding portion. The covering part and the main body part are adapted to match and be engaged with each other to form the bracket having a smooth curved shape in a gingival direction, an occlusal direction, a mesial direction and a distal direction.
US10201395B2	Filter module packaging unit A sterile filter module/dialyzer packaging including a filter module, preferably a dialyzer, sterile-packaged in a primary packaging. The filter module having an essentially cylindrical central section and a filter module connection formed at the end of the central section. The primary packaging is a blister packaging with a plastic molded part as a lower section forming a receiving compartment for the filter module and a soft upper foil which, with the lower section, closes the receiving compartment for the filter module. The upper foil is fixed onto the lower section so as to be hermetically sealed and the filter module is fixed at least in sections by means of form fit.
US10201385B2	Catheter adapted for direct tissue contact An irrigated ablation catheter adapted for direct tissue contact has micro-elements that provide more accurate sensing of tissue, including thermal and electrical properties for temperature and impedance measurements. The micro-elements extend through a hollow chamber of an irrigated ablation electrode, and distal ends thereof can protrude outside of electrode or be flush with the electrode. The micro-elements have a protective guide tube in which components enabling temperature sensing or electrical sensing are encased.
US10201383B2	Methods for tissue ablation measurement and control and devices thereof An apparatus comprises a first longitudinal member and a second longitudinal member configured to be located near a tissue region. An energy source is coupled to first longitudinal member and second longitudinal member. A measuring device is configured to measure at least one characteristic of the tissue region. An energy controller is coupled to the energy source and the measuring device. The energy controller includes a processor coupled to a memory and configured to execute programmed instructions stored in the memory, comprising initiating a delivery of energy to the tissue region from the energy source. One or more items of data are received from the measuring device based on the delivery of energy to the tissue region. The delivery of energy to the tissue region is adjusted based on the one or more items of data.
US10201380B2	Treatment systems, methods, and apparatuses for improving the appearance of skin and providing other treatments Treatment systems, methods, and apparatuses for improving the appearance of skin or other target regions are described as well as for providing for other treatments. Aspects of the technology are directed to improving the appearance of skin by tightening the skin, improving skin tone or texture, eliminating or reducing wrinkles, increasing skin smoothness, or improving the appearance of cellulite. Treatments can include cooling a surface of a patient's skin and detecting at least one freeze event in the cooled skin. The treatment system can continue cooling the patient's skin after the freeze event(s) are detected so to maintain at least a partially frozen state of the tissue for a period of time.
US10201377B2	Methods for correction of spinal deformities A method of treating a spinal column shape deformation includes fixing at least two fixation screw assemblies to respective vertebrae, sliding a rod between the arm extensions on each of the fixation screw assemblies, swinging the channels of the screw assemblies relative to the fixation screws so that the channels become less inclined to the axes of the fixation screws, and so that the rod is located generally posteriorly of the spinal column, locking the channel against swinging relative to the screw, rotating the rod about its axis relative to at least one of the channels, and locking the rod against movement relative to the channel.
US10201376B2	Periprosthetic plating system including plate with system for retaining tension on a cable A system, devices and methods are provided for facilitating stabilization of periarticular fractures. The system includes a compression plate and one or more of a cerclage cable for encircling the bone and securing the compression plate to the bone, a crimp lug for securing the cable in tension relative to the bone and/or a plate, and a supplemental plate coupled to the compression plate and adapted to receive bicortical or unicortical bone screws to further secure the compression plate relative to the bone. In addition, the system includes a cable tensioner for temporarily retaining the cable in tension and then applying a tension to the cable until a desired compression is effected between a plate and bone and while a cable retaining structure is secured to the cable to retain the applied tension on the cable. Also provided is a jig for use with plates for minimally invasive fracture stabilization.
US10201374B2	Assembly tool for a prosthesis An assembly tool for assembling components of an implant can include a finger assembly, a handle assembly, and a crossbar assembly. The finger assembly can include first and second fingers oriented parallel to each other, and sized and shaped to releasably engage first and second components of the implant during assembly. The handle assembly can include first and second handles pivotally connected to each other and configured to control movement of the first and second fingers. The crossbar assembly can be configured to maintain the first and second fingers substantially parallel to each other during movement of the first and second fingers. The assembly tool can be used for assembling a bearing assembly to an ulnar component of an elbow prosthesis.
US10201372B2	Cannula for a surgical instrument This disclosure relates to a cannula for a surgical instrument used for cutting selected tissue in a body cavity while under visual inspection. A kit containing the cannula and methods for performing surgical procedures using the cannula are also described.
US10201371B2	Surgical device A port for laparoscopic surgery comprises an opening for attachment to a wound protector and a flexible membrane extending therefrom to define an airtight seal around an incision in a patient. A plurality of access points are defined in the membrane, through which laparoscopic trocars and elongate laparoscopic surgical instruments can be inserted.
US10201367B2	Tissue collection needle A tissue collection needle with a hollow interior provides two opposing tips with beveled edges on facets that drive tissue toward the hollow interior where the tissue can be gathered and severed from surrounding tissue as the needle advances through a biological specimen. The points and bevels are advantageously formed from a minimal number of cuts amenable to rapid fabrication from readily available hollow needle stock.
US10201364B2	Surgical instrument comprising a rotatable shaft Various electrical and slip ring connector arrangements configured to facilitate the passage of electrical current and signals between two components that are rotatable relative to each other such as an interchangeable surgical shaft assembly that includes portions that are rotatable relative to fixed mounting portions.
US10201362B2	Contoured surgical forceps A contoured forceps handle is presented having a first arm with a contoured surface and a second arm with a contoured surface to provide for rotation in the hand of a user. The forceps handle may be used with a forceps or may have tips attached. Contoured forceps onlays are also presented that may be attached to forceps.
US10201361B2	Method and devices for performing minimally invasive surgery A device for use in performing minimally invasive surgery. A system for performing minimally invasive surgery comprising the device according to the present invention. A method for performing minimally invasive surgery.
US10201357B2	Customized patient-specific revision surgical instruments and method A surgical instrument including a customized patient-specific guide block is disclosed. The customized patient-specific guide block includes a first surface, a bone-facing surface, a second surface positioned opposite the first surface and the bone-facing surface, and a guide pin hole extending between the second surface and the bone-facing surface. The first surface has a customized prosthesis-specific negative contour shaped to match a corresponding contour of a prosthetic component, and the customized prosthesis-specific negative contour includes a concave surface shaped to match a convex surface of the corresponding contour of the prosthetic component. A method of performing an orthopedic surgical procedure is also disclosed.
US10201354B1	Tourniquet safety sleeve for reducing limb injury A sleeve for use with a tourniquet cuff to protect a patient's limb from tourniquet-related injury includes a stretchable body extending longitudinally over a sleeve length between a proximal end and a distal end. The body has a tubular shape, and the sleeve length is greater than a width of the tourniquet cuff. The body tapers from the proximal end to the distal end such that a proximal end circumference is greater than a distal end circumference. The body is formed to apply substantially uniform pressure to the patient's limb from the proximal end of the sleeve to the distal end of the sleeve varying only within a predetermined pressure range.
US10201351B2	Continuous embolic coil and methods and devices for delivery of the same An occlusion system (5) provides a trimmable continuous embolic coil (10) that is “cut to length” at the end of its deployment into the target occlusion site. A delivery device (15) provides the “cut to length” feature for the continuous embolic coil.
US10201347B2	Loading unit velocity and position feedback A loading unit for a surgical stapling device has a cartridge assembly and an anvil assembly, the cartridge assembly including a channel and a staple cartridge having a plurality of surgical staples therein. An axial drive assembly has a clamping member, the clamping member having an upper flange for engaging the anvil assembly, and a lower flange for engaging the channel. The axial drive assembly is movable through the staple cartridge to drive the staples out of the staple cartridge and against the anvil assembly. Mechanical features are defined in the channel for indicating an end of stroke for the axial drive assembly, the mechanical features having a first pattern and a second pattern.
US10201344B2	Knotless suture anchor and method of using same A suture anchor including an outer anchor part and an inner anchor part. The outer anchor part includes a proximal end, a distal end, and an inner surface defining a center bore extending between the proximal end and the distal end. The center bore includes a tapered proximal portion. The inner anchor part includes a tapered outer surface defining a first pair of opposing apertures. Insertion of the inner anchor part into the tapered proximal portion of the outer anchor part enables a suture extending through the first pair of opposing apertures to be coupled to the suture anchor. A taper fit between the tapered proximal portion of the center bore of the outer anchor part and the tapered outer surface of the inner anchor part retains the inner anchor part within the outer anchor part.
US10201336B2	Device and method for delivering a vascular device A device and method for delivering a vascular device to a target site is provided that allows an orientation of the vascular device at the target site to be adjusted by a user. In general, the delivery device includes an outer tubular member, an intermediate tubular member within the outer tubular member, and an inner member that can move axially within the intermediate tubular member. Each of the members defines a proximal end and a distal end. The intermediate and outer tubular members are fixed at their respective proximal ends, but are not fixed at their distal ends. Thus, a torque applied to the proximal end of the intermediate tubular member is at least partially transmitted to the distal end of the intermediate tubular member, allowing the user to rotate an attached vascular device by rotating the proximal end of the intermediate tubular member.
US10201328B2	Ultrasonic diagnostic apparatus and manufacturing method thereof Disclosed herein are an ultrasonic diagnostic apparatus, and a manufacturing method thereof. The ultrasonic diagnostic apparatus includes: a matching layer; a flexible printed circuit board having steps at both edge portions; a piezoelectric layer disposed below the matching layer and on the flexible printed circuit board such that a first electrode and a second electrode of the piezoelectric layer, between which steps are formed and which are separated from each other by polarization areas, are respectively connected to a first electrode and a second electrode of the flexible printed circuit board; and a backing layer disposed below the piezoelectric layer.
US10201327B2	Organic specimen feature identification in ultrasound data A system, method, and non-transitory computer-readable medium. The system includes a processor configured to receive reference ultrasound data from ultrasound reflected waves received from specimen features in an organic specimen resultant from reference ultrasound incident waves transmitted into the organic specimen, wherein positional awareness of each ultrasound reflected wave relative to the organic specimen is maintained; to identify a reference propagation region in the organic specimen into which the reference ultrasound incident waves were transmitted into the organic specimen and a corresponding reference model image region in anatomic model data corresponding to at least part of the organic specimen; and to receive additional ultrasound data from ultrasound reflected waves received from specimen features in the organic specimen resultant from additional ultrasound incident waves transmitted into the organic specimen, wherein positional awareness is maintained between the reference propagation region and a propagation region of the additional ultrasound data.
US10201325B2	Controlled tissue dissection systems and methods Tissue dissecting device, including an inflatable bladder configured to be inserted into a body via an introducer tube in a compact deflated state, and to be inflated to a substantially planar form in a manner which dissects tissue. Method for dissecting tissue, including inserting an inflatable bladder, in a deflated state, via an introducer tube, into a space in a body, and inflating the bladder to substantially planer form, thereby dissecting tissue. Method for dissecting tissue, including inserting an introducer tube via an incision into a body, inserting an inflatable bladder, in a defined state, via the introducer tube, into a space in the body, pulling the introducer tube back at least a length of the deflated bladder, inflating the bladder, via a filling tube, to substantially planar form, thereby dissecting tissue, disconnecting the filling tube from the bladder, retracting the filling tube and the introducer tube from the body.
US10201322B2	Computed tomography scanning apparatus, gantry rotation control device and method thereof A gantry rotation control device for a computed tomography scanning apparatus. The gantry rotation control device includes a radiation dose determination unit for determining radiation doses of the X-rays that will be emitted to each site of the target object to be scanned, a minimum velocity determination unit for determining a minimum rotation velocity of the gantry according to a maximum radiation dose in the determined radiation doses, a maximum velocity determination unit for determining a maximum rotation velocity of the gantry according to the determined minimum rotation velocity, a rotation velocity determination unit for determining a rotation velocity of the gantry at any time during scanning of the target object according to the determined minimum rotation velocity and maximum rotation velocity, and a gantry rotation control unit for controlling the gantry to scan the target object while rotating according to the determined rotation velocity when the target object is to be scanned.
US10201321B2	Low-dose CT perfusion technique Methods and apparatuses are disclosed for quantifying regional organ perfusion with low radiation dose using whole-organ CT in a patient comprising obtaining a computed tomography scan of the patient and determining perfusion of the organ using a first-pass analysis method in conjunction with conservation of mass for perfusion measurement.
US10201320B2	Deformed grid based intra-operative system and method of use The subject of this invention is a system and method for distortion adaptation for use with an imaging grid alignment apparatus (analog or digital) and method of intra-operative use for joint replacements, spine, trauma fracture reductions and deformity correction and implant placement/alignment. The system provides for real time dynamic position tracked distortion-adaption grid.
US10201314B2	System and method for evaluation of circulatory function A system and method for evaluating a circulatory function of an individual includes at least one connection configured to receive signals indicative of functional data relating to at least one functional parameter of the cardiovascular system of the subject and to at least two disparate locations on the subject. A processor is coupled to the at least, one connection and configured to receive the functional data from the at least one connection. The processor is also configured to compare the functional data to identify variations that deviate from an expected delay associated with the disparate locations and provide an assessment of the cardiovascular system function based on the comparison of the functional data.
US10201311B2	Expandable catheter assembly with flexible printed circuit board (PCB) electrical pathways Provided is a flex-PCB catheter device that is configured to be inserted into a body lumen. The flex-PCB catheter comprises an elongate shaft, an expandable assembly, a flexible printed circuit board (flex-PCB) substrate, a plurality of electronic components and a plurality of communication paths. The elongate shaft comprises a proximal end and a distal end. The expandable assembly is configured to transition from a radially compact state to a radially expanded state. The plurality of electronic elements are coupled to the flex-PCB substrate and are configured to receive and/or transmit an electric signal. The plurality of communication paths are positioned on and/or within the flex-PCB substrate. The communication paths selectively couple the plurality of electronic elements to a plurality of electrical contacts configured to electrically connect to an electronic module configured to process the electrical signal. The flex-PCB substrate can have multiple layers, including one or more metallic layers. Acoustic matching elements and conductive traces can be includes in the flex-PCB substrate.
US10201310B2	Calibration packaging apparatuses for physiological monitoring garments A calibration packaging apparatus for a physiological monitoring garment is disclosed. The apparatus comprises a chamber to hold a physiological monitoring garment with a plurality of position sensors, motion sensors, or position and motion sensors. The apparatus is configured to calibrate the plurality of position sensors, motion sensors, or position and motion sensors simultaneously during a calibration process in which the apparatus is moved through a predetermined pattern and/or a random pattern. Methods of calibrating using the apparatus are also disclosed.
US10201302B2	Systems and methods for determining whether regional oximetry sensors are properly positioned Methods and systems are presented for determining whether a regional oximetry sensor is properly positioned on a subject. First and second metric values may be determined based on respective first and second light signals. The first and second metric values and a relationship between the first and second metrics are used to determine whether the sensor is properly positioned on the subject. The first and second metrics may form a pair of metrics, and whether the sensor is properly positioned on the subject may be determined based on whether the pair of metrics falls within a sensor-on region. In some embodiments, a plurality of metrics may be determined based on a plurality of received physiological signals. The plurality of metrics may be combined, using, for example, a neural network, to determine whether the regional oximetry sensor is properly positioned on a subject.
US10201299B2	Reducing non-reversible cross sensitivity for volatile acids or bases in chemo-optical sensor spots The present invention relates to a chemo-optical sensor unit for transcutaneous measurement of a concentration of a gas, comprising: at least one gas-permeable sensing layer adapted to be irradiated with a predetermined radiation; and at least a first gas-permeable layer adjacent to one side of the at least one sensing layer, adapted to pass gas whose concentration is to be measured through the gas-permeable layer towards the sensing layer; at least one volatile acid and/or base binding layer in the gas-pathway from the skin to the sensing layer; adapted to pass gas whose concentration is to be measured through the volatile acid and/or base binding layer towards the sensing layer; wherein said chemo-optical sensor unit is adapted to operate with a contact medium between the chemo-optical sensor unit and the skin and wherein the chemo-optical sensor unit is adapted to measure an optical response of the at least one sensing layer, whose optical response depends on the concentration of the gas. The present invention also relates to a system for patient monitoring and/or ventilation of a patient comprising such a chemo-optical sensor.
US10201296B2	Apparatus, systems, and methods adapted to transmit analyte data having common electronic architecture Embodiments provide apparatus, systems, and methods adapted to communicate analyte data and/or related information. In a first aspect, the apparatus includes a transmitter/receiver unit which is configurable as either a transmitter or a receiver. The transmitter/receiver unit may be coupled to an on-body sensor and may be configured as a transmitter, or may be coupled to a management unit and may be configured as a receiver as part of a continuous analyte monitoring system. Analyte data communication systems and methods are provided, as are other aspects.
US10201292B2	Activity monitors An activity monitor that is worn by a user for monitoring water-based activities. The activity monitor includes at least one motion sensor, a water sensor, a memory, and a processor. The processor is operable to run an algorithm to calculate activity data based on an output from the motion sensor and to save the activity data to the memory. The processor can be triggered to operate to calculate the activity data and to save it to memory by an output from the water sensor to indicate that the monitor is immersed in water.
US10201291B2	Apparatus and method for real-time tracking of bony structures A method for measuring skin thickness. The method includes at a first 3D point on an outer surface of a patient, exposing the first point to near infrared (NIR) energy from an NIR source. The method includes measuring reflected energy emanating near the first 3D point, or beam incident point. The method includes determining a pattern of the reflected energy based on a distance from a center of the reflected energy, wherein the center is approximated by the first 3D point. The method includes determining a skin thickness measurement based on the pattern.
US10201281B2	System, method and article for normalization and enhancement of tissue images In medical imaging, a fiducial marker facilitates tissue image correlation that allows for image analysis, normalization and correction of the optical exposure and spectral and spatial distribution in order to compensate for the surface reflections, sub surface tissue interactions and spatial orientation of the excitation and imaging axes to the subject tissue. Using a cross comparison, clinicians can model tissue image data in different forms in order to reference and compare data from various spectral components and or from different images. This may enhance human interpretation between images including the variations between images even when the spectral, spatial and optical conditions or the image resolution or sensitivity are compromised. Such may be used to assess cosmetic, moisturizing, therapeutic materials and treatments.
US10201277B2	Systems, devices, components and methods for detecting the locations of sources of cardiac rhythm disorders in a patient's heart Disclosed are various examples and embodiments of systems, devices, components and methods configured to detect a location of a source of at least one cardiac rhythm disorder in a patient's heart. In some embodiments, electrogram signals are acquired from inside a patient's heart, and subsequently normalized, adjusted and/or filtered, followed by generating a two-dimensional (2D) spatial map, grid or representation of the electrode positions, processing the amplitude-adjusted and filtered electrogram signals to generate a plurality of three-dimensional electrogram surfaces corresponding at least partially to the 2 D grid, one surface being generated for each or selected discrete times, and processing the plurality of three-dimensional electrogram surfaces through time to generate a velocity vector map corresponding at least partially to the 2 D grid. The resulting velocity vector map is configured to reveal the location of the source of the at least one cardiac rhythm disorder, which may be, by way of example, an active rotor in a patient's myocardium and atrium.
US10201276B2	Optical measurement systems and processes with wavefront aberrometer having variable focal length lens An optical measurement system: passes a probe light beam through a variable focal length lens to the retina of an eye, and returns light from the retina through the variable focal length lens to a wavefront sensor; adjusts the focal length of the variable focal length lens to provide a desired characteristic to at least one of: the probe light beam, and the light returned by the retina to the wavefront sensor; passes a calibration light through the variable focal length lens to the wavefront sensor while the variable focal length lens is at the adjusted focal length to ascertain the adjusted focal length; and makes a wavefront measurement of the eye from the light returned from the retina of the eye through the variable focal length lens to the wavefront sensor, and from the adjusted focal length ascertained from the calibration light received by the wavefront sensor.
US10201274B2	Eye tracking system with biometric identification A method for measuring eye tracking in a patient and capturing ocular biometric identifying information from the patient may involve: displaying a video to the patient on a stimulus screen of an eye tracking and biometric identification system; tracking movement of the patient's eyes during display of the video via an eye tracking camera of the eye tracking and biometric identification system; capturing ocular biometric identifying information from the patient with an ocular biometric capture device of the eye tracking and biometric identification system; generating, with a computer processor of the eye tracking and biometric identification system, a score representing an ability of the patient's eyes to track the video; and confirming, with the computer processor, an identity of the patient, based on the captured ocular biometric identifying information.
US10201271B2	Eye measurement In a method for interferometrically capturing measurement points of a region of an eye, a plurality of measurement points are captured by a measurement beam along a trajectory, wherein the same trajectory is passed over by the measurement beam in the region during at least a first iteration and a second iteration. The trajectory of the first iteration is rotated through an angle and/or displaced by a distance in relation to the trajectory of the second iteration in order to obtain a more homogeneous measurement point distribution.
US10201268B2	Polarizing endoscopy system and method A medical device comprising an instrument head integral to the medical device having a distal portion, a light source internal to the instrument head coupled to a first channel, a first polarizing filter positioned within the first channel of the instrument head, a second polarizing filter positioned within the second channel for receiving reflected light from the light source, the reflected light received through a sensor axially aligned with the second channel is disclosed herein. The second channel may comprise a distal opening. The second channel may be configured to restrict light from entering the second channel other than by the distal opening. The first polarizing filter may be configured to polarize light from the light source.
US10201266B2	Single image sensor control for capturing mixed mode images A method and apparatus for capturing an image sequence using a capsule camera are disclosed. According to the present invention, a first energy-based frame time for the special images is determined based on first light energy perceived by the image sensor and a second energy-based frame time for the regular images is determined based on second light energy perceived by the image sensor. The capsule camera captures the image sequence comprising one or more sets of mixed-type images by configuring the capsule camera to cause a mixed-frame distance between the first energy-based frame time for one special image in a target set of mixed-type images and the second energy-based frame time for one regular image in the target set of mixed-type images smaller than an average frame period.
US10201265B2	Microwave ablation catheter, handle, and system A support system including a rail, a lower support, and an instrument support. The lower support is configured to receive a portion of a bronchoscope and to selectively fix the bronchoscope relative to the rail. The instrument support is slidably disposed on the rail and is selectively lockable to the rail. The instrument support is configured to releasably couple to a surgical instrument inserted through the bronchoscope to fix the position of a portion of the surgical instrument relative to the bronchoscope.
US10201262B1	Lobby dustpan A lobby dustpan is self-standing, self-closing and comprises a lid-handle coupling feature for receiving a broom head for retaining the broom head in the bucket of the lobby dustpan. The lid of the lobby dustpan substantially covers the opening of the bucket when in a closed position. A lobby dustpan is self-standing, wherein the center of gravity is between the outer contact points of the base. In addition, when the lobby dustpan is standing in an upright position on a horizontal surface, the center of gravity of the handle keeps the lid in a closed position. Furthermore, the center of gravity of the bucket is offset from the pivot assembly which causes the bucket to close when the lobby dustpan is lifted up from an open position. The specific geometry of the lobby dustpan enables a combination of features that heretofore are not available with existing lobby dustpans.
US10201259B2	Cleaner A vacuum cleaner is provided. The vacuum cleaner comprising a hand-held device, in which the hand-held device includes: a housing defining an air inlet, an air outlet and an air blowing port therein, the air blowing port being disposed adjacent to the air inlet; a dust cup disposed in the housing and connected with the air inlet; and an electric motor defining a motor chamber, wherein an airflow entering through the air inlet switchably flows out of one of the air outlet and the air blowing port by a switching mechanism after flowing through the dust cup and the electric motor.
US10201256B2	Paper cutting device easy to be disassembled and maintained A paper cutting device includes a support frame, first rotating shaft and cover. The support frame is defined with an accommodation space with a forward opening, and the two ends of the accommodation space are in combination with two side plates in opposite to each other; the first rotating shaft is configured between the two side plates and positioned in the accommodation space, allowing the first rotating shaft to be rotated in the accommodation space; the cover is in movable combination with the two side plates of the support frame and positioned relatively at the forward opening of the accommodation space, the cover adapted to cover the first rotating shaft. Furthermore, a knife assembly is mounted in a breach configured on the first rotating shaft, and protruding shafts configured on the two ends thereof can be slid in corresponding closed annular guide grooves configured on the two side plates.
US10201252B2	Expanding curtain An expanding curtain may be provided that does not require the addition or installation of a new curved rod and/or any external mechanical devices such as curtain supports, control devices, or adapters to expand the usable space in the enclosure area. Rather, the curtain itself may have the strength, rigidity and/or fortitude to form an outwardly extended shape (e.g., away from the enclosure area) that may hold it in place, thus, expanding the amount of space available for utilization by the user of the enclosure area. The curtain easily and rapidly mounts and thereafter may be easily slidable/manipulated between an open and closed position. The curtain may surround, divide and/or provide privacy to a specific area and/or confined space. The curtain may also maintain a mold, mildew and germ resistant facade, while remaining inexpensive to manufacture.
US10201250B2	Thermoformed container with lid A container assembly includes a thermoformed tub of relatively thin plastic material having a peripheral wall extending to an upper edge and defining a product containing space. A lower rim is connected to the upper edge of the tub, the lower rim defining an opening giving access to the product containing space and being formed of a relatively thicker plastic material. An upper rim is connectable to the lower rim and a lid is provided for selectively closing the opening. By the use of a thin walled thermoformed tub, the amount of material required for forming the body of the container is limited. Furthermore, the lower rim of relatively thicker plastic material provides the required support to the relatively thin material of the peripheral wall, allowing effective connection to the upper rim.
US10201248B2	Coffee grinding machine A coffee grinding machine including a first burr and a second burr. At least one of the first burr and the second burr is rotatable about an axis of rotation, the burrs being mutually cooperating to grind coffee. The machine includes a motor which rotates at least one of the burrs with respect to the other, wherein the axis of rotation of the motor does not coincide with the axis of rotation of the burrs so that the coffee which is ground by the grinders is directed to an output of a conveyor cone for use thereof.
US10201247B1	Pellet grill with electric searing station A grill includes a cooking surface. The cooking surface includes at least one grate. The grate has internal heating elements operable to raise the temperature of the great above the temperature achievable via a heat source of the grill. The grate may be referred to as a searing station. In one embodiment, the grill is a wood pellet grill, the heat source is burning wood pellets in a burnpot of the grill, and the heating elements are resistive heating elements fully contained within slats of the grate. A searing station is especially suited for wood pellet grills which operate at lower temperatures than conventional gas or charcoal grills because it combines the slow cooking characteristics of a pellet grill with the quick searing capabilities of an infrared gas grill. The searing station may, however, be used in any type of grill.
US10201244B2	Packaging system for infant nutritional composition with dosing devices A packaging system for infant nutritional composition with dosing devices (304, 305), comprises a first dosing device (304) for dispensing a first quantity of said infant nutritional composition, said first quantity being adapted to boys, and a second dosing device (305) for dispensing a second quantity of said infant nutritional composition, said second quantity being adapted to girls, said first quantity being different from said second quantity.
US10201242B2	Garment stretcher A garment stretcher. The garment stretcher includes an elongated weight having a first end, a second end, and a midpoint. A first clip is connected to the first end of the elongated weight, a second clip is connected to the second end of the elongated weight, and a third clip is connected to the third end of the elongated weight. Each of the clips is removably securable to a garment such as a shirt. When the elongated weight is secured to the lower end of a hanging garment, the elongated weight exerts a downward force on the garment and causes it to stretch and lengthen over time. The even spacing of the clips ensures that the shirt is stretched in a uniform manner.
US10201239B2	Headphone case having fixed or inflatable cushion A headphone case is provided that serves as both a case for storing headphones and other objects, and a cushion to be worn around the neck. The case has either a fixed cushion located on different parts of the case, or a material that can be inflated, where the material has an outside layer comprising a cushion material. The case has two halves, a top half and lower half, which are held together by one or more hinges or other means. The headphone case can have a control unit for electronically inflating the material on the case, and for controlling units inside the case for controlling an amount and intensity of heat and vibration. Software can be uploaded to the control unit via a USB port or a Bluetooth antenna for controlling the different functions of the case. An application running on a phone, tablet or computer may control the functions of the various units inside the case.
US10201237B2	Automated hygienic cutlery dispenser A hygienic automatic electric utensil dispenser for use in eating establishments such as hospitals, schools, or other areas where large number of people are eating food in a central area. The dispenser can be refilled using prepackaged stacked plastic utensil in a self-sealing plastic bags without the user ever touching the utensil during the refilling process. The dispenser delivers the utensil in a sanitary method using a plurality of sensors.
US10201234B2	Inflatable air mattress system architecture A method may comprise receiving, at a central controller, a command, from a remote control, to adjust a feature of a first component of an air mattress framework; relaying, from the central controller, the command to the first component; receiving from the first component at the central controller, an indication of the success of the command; and relaying the indication from the central controller to the remote control.
US10201233B2	Modular basin apparatus A modular basin apparatus includes a first panel, a second panel and a third panel. The panels include a plurality of slots that receive portions of the other panels. A user may assemble the panels to form a three-dimensional basin apparatus. A concave cavity is formed on the upper side of the apparatus when assembled, and the cavity may be receive materials depending on the application of the assembly. In some embodiments, the apparatus may be used as a modular fire pit, chair, table, or other device. A fourth panel may rest against the first, second and third panels to provide an upper surface. In some embodiments, all panels include the same planform profile and outer dimensions such that they may be stacked in an arrangement having a uniform outer profile for improved transport and storage.
US10201232B2	Shelf attachment for lounge chair A shelf attachment for use with a beach or lounge chair is formed of one-piece or has a first shelf half and a second shelf half hingedly and foldably connected to the first shelf half. An elongated member extends through interlocking projections extending from the first shelf half and from the second shelf half to hingedly connect the first and second shelf halves. A first clamp assembly is secured to the first shelf half and a second clamp assembly is secured to the second shelf half to mount the shelf to the rail of a chair.
US10201229B2	Patio table that converts into a clothesline The patio table that converts into a clothesline is easily transformed from a patio table into a functional clothesline. The arms, crossbars and clotheslines easily fold out and retract back into the patio table. The patio table may be made out of different materials such as pvc, aluminum, wood or steel. It may be manufactured in different sizes.
US10201227B2	Shelving bracket capable of electrical connectivity This support apparatus includes a fixation member and a support member attachable to and detachable from an opening portion of the fixation member. A first upper surface portion of the opening portion is formed of: a first front surface portion sloped in a downward direction; and a first rear surface portion formed continuously from the first front surface portion and sloped in an upward direction. A first lower surface portion is sloped in parallel with the first front surface portion. A second upper surface portion of the support member is formed of: a second front surface portion to contact the first front surface portion; and a second rear surface portion to contact the first rear surface portion. A second lower surface portion is sloped in a downward direction, at a slope angle, so as to contact with an opening-side end of the first lower surface portion.
US10201224B2	Device for fixing a frame in a through-orifice in a panel A device for fixing a frame in a through-hole extending between two opposite faces of a panel the frame including a peripheral wall having an upper and lower edges and configured to cover a structure of the panel delimiting the through-hole the upper edge including an edge configured to rest against a first face of the panel, wherein the device includes a clamping element including an arm integral with a perpendicular tab and an assembly structure configured to secure the tab on the second face of the panel in the vicinity of the through-hole, the arm configured to exert, a force on the peripheral wall adapted to flatten the peripheral wall against the structure of the panel defining the through-hole and to exert a force on a stop of the peripheral wall adapted to flatten the ledge of the frame against the first face of the panel when the tab is fixed on the second face of the panel.
US10201222B2	Brush head and its producing device A brush includes a brush head which comprises a brush support, and a plurality of brushing members integrally provided on the brush support, wherein the brushing members and the brush support are integrally formed together by heat treatment.
US10201218B2	Receptacle having locking handles A receptacle including a wall portion extending from a bottom surface to a rim, the rim having an internal lip extending around the rim, wherein the wall portion includes at least one recessed area to accommodate a side of a user when the user is carrying the receptacle, a first handle operably attached to the receptacle, and a second handle operably attached to the receptacle, wherein the first handle and the second handle releasably engage each other to form a single carrying handle, is provided. Furthermore, an associated method is also provided.
US10201215B2	Composite pull tab and zipper applying same A composite pull tab and a zipper applying same. The pull tab includes two metal decoration parts spaced from each other, namely a first metal decoration part and a second metal decoration part; connecting through holes are respectively provided on an inner leg portions of the two metal decoration parts; an electrostatic eliminating unit is electrically connected between the inner leg portions of the two metal decoration parts; the pull tab further comprises a plastic encapsulation part; the plastic encapsulation part is welded on the inner leg portions of the two metal decoration parts and fills the connecting through holes so as to fixedly connect the two metal decoration parts as a whole; the electrostatic eliminating unit is accommodated in the plastic encapsulation part; and outer leg portions of the two metal decoration parts are respectively exposed outside the plastic encapsulation part.
US10201214B2	Loop surface fastener having excellent positioning function A loop surface fastener in which numerous looped engaging elements formed from loop yarns inserted in parallel to ground warp yarns are provided upright on one side of a base fabric formed from ground warp yarns and ground weft yarns satisfies all the following requirements 1) to 3). 1) The loop yarn is a multi-filament yarn formed by bundling 5 to 9 filaments of 30 to 45 decitex. 2) The density of the looped engaging elements is in a range of 100 to 200/cm2. 3) Loop surfaces of the looped engaging elements are substantially facing in the same direction and the loop surface facing direction is a ground weft yarn direction.
US10201209B2	Miracle heel A convertible shoe may include a lightly padded and flexible sole to facilitate a comfortable fit and steady footing and a removable heel. A new shoe having removable heels for permitting a user to wear a single pair of shoes which can be used in high heel form and in a flat form is disclosed. The new shoe device includes a sole having opposite heel and toe ends. The device further includes a disjoined heel removable from the heel of the sole. The heel includes a slot that extends linearly the length of the heel. The heel of the sole includes a recessed portions that extends the length of the sole that is removable engaged therewith.
US10201206B2	Lacrosse helmet A lacrosse helmet comprises rigid single-piece shell formed of a suitable material such as polycarbonate or ABS plastic and adapted to receive and protect the head of a wearer. The shell has acclivities integrally formed therein to define features in the shell. Two alternative padding assemblies are disclosed. In a first alternative, the padding assemblies include a front liner installed in the brow area of the shell, a lateral liner extending around the back inner surface of the shell and backed by an inflatable occipital pad, a crown shock absorber, and jaw pads. In a second alternative, the padding assemblies include an inner shell or bonnet comprising a left section, right section, and rear section, which are assembled together with a crown comfort layer and a rear comfort layer, and inserted into the shell. This alternative also includes jaw pads as in the first alternative.
US10201205B2	Helmet liner A helmet liner and a helmet assembly including a liner. A helmet liner includes a plurality of panels, each of the plurality of panels coupled to and foldable relative to at least one other panel of the plurality of panels at a seam, each of the panels including a gel layer.
US10201204B2	Light-emitting helmet and manufacturing method thereof A light-emitting helmet is provided. The helmet includes a main body, a number of fixing members, and a number of light-emitting lamp strips. The main body includes a shell and inner layer. The shell includes an outer surface and a number of grooves defining in the outer surface. The fixing members are secured in the inner layer. The lamp strips are detachably mounted in the grooves by the fixing frames respectively. In addition, a light-emitting helmet manufacturing method is also provided.
US10201202B2	Wearable disease prevention device A wearable device for preventing the spread of disease by detecting when a wearer's hand comes into close proximity of the wearer's face. The device can preferably issue an immediate warning to the wearer to prevent contact between the wearer's hand and face and to change a wearer's face-touching habit in order to prevent future occurrences. More specifically, the device can be comprised of a housing, a backer, magnets to attach the backer to the housing, a signal emitter, a plurality of sensors, a micro USB charge port, and a power button.
US10201199B2	Glove finger attachment system A glove apparatus is disclosed comprising a substantially glove-shaped first layer, a substantially glove-shaped second layer, and an attachment tab comprising a lower portion, an upper portion, and an extension portion. The attachment tab is attached to a finger portion of the second layer along the lower portion and along the upper portion. The extension portion extends from the attachment tab at a location distal from a fingertip of the second layer and overlies the upper portion to an attachment region on the first layer proximate a fingertip of the first layer, the fingertips of the first layer and of the second layer thereby lying substantially near or in contact with one another.
US10201198B2	Protective masks with coating comprising different electrospun fibers interweaved with each other, formulations forming the same, and method of producing thereof The present invention provides a protective mask with an ultrafine fibrous coating. The ultrafine fibrous coating includes partially gelled submicron fibers interweaved with nanofibers and a biocide encapsulated in, surface-attached onto, blended with, physically trapped, and/or chemically linked to the submicron fibers and nanofibers. In an example, a microfibrous substrate with the coating assembles with other microfibrous substrates to form a protective mask having N95 level of protection and bacteria-killing capability.
US10201197B2	Knee protection device Disclosed is knee protection equipment including: a unit for resting on the ground, intended to be positioned in the immediate vicinity of the knee, and/or the unit resting on the ground being intended to be positioned level with the tibia; a harness intended to be arranged level with the pelvis; the harness and the unit for resting on the ground being connected by a rigid arm intended to be positioned laterally and externally to the thigh, the equipment being able to pass from a standing position in which the unit for resting on the ground are positioned level with the knee and/or level with the tibia, to a kneeling position in which the unit for resting on the ground bear on the ground and are able to transmit at least part of the vertical load force to the harness.
US10201196B2	Protective sports shin guard A protective shin guard includes a floating knee section attached to a shin section, both sections being formed of a hard outer shell overlying a non-rigid inner padding layer. The hard outer shell of the shin section is defined by a unique pattern of flexible hinges. An alternate embodiment that uses pliable transition inserts is also described. In addition, the shin guard is attached to the leg by a novel strap system including two elastic calf straps and one greater-than 360 degree behind-the-knee compression strap that combine to provide maximum protection to the user's shin and knee while maintaining flexibility.
US10201195B1	Heating system for heated clothing Methods and systems for heating of heated clothing are provided. An example system may include system comprising one or more heating components placed within one or more zones of the heated clothing and configured to receive electrical current from one or more voltage converters independently. The system may also include a battery configured to provide power to the voltage converters. The system may also include a controller configured to control an output voltage of the one or more voltage converters, wherein the output voltage is provided to the one or more heating components. The controller may be configured to receive temperatures from the temperature sensors located in heating components, an ambient temperature from the ambient temperature sensor, and user-defined temperatures. The controller may adjust the output voltage based on the temperatures received from the temperature sensors and adjust ambient temperature and user-defined temperatures.
US10201187B2	User interface for an aerosol delivery device An aerosol delivery device is provided that includes a user interface including a pushbutton and a display. A control component contained coupled to the user interface controls operation of at least one functional element of the aerosol delivery device. The control component controls the display to present a menu including a plurality of menu items selectable using only the pushbutton. Each menu item of the plurality of menu items is associated with a respective functional element of the aerosol delivery device, and the control component is configured to navigate the plurality of menu items, and select a currently-presented menu item of the plurality of menu items for control of the respective functional element, in response to respective first and second types of presses of the pushbutton, the first and second types of presses being of different durations.
US10201185B2	Vaporizer device A vaporizer device includes a cartridge configured to hold a vaporizable substance, a wick element coupled to the cartridge, where the wick element is configured to contact the vaporizable substance located in the cartridge and an induction heating element inductively coupled to the wick element, where the wick element is configured to heat the vaporizable substance based on induction heating of the wick element by the induction heating element.
US10201176B2	Oxidized flavor note suppression in comestibles Comestibles prepared using 1,3-propanediol may include modified flavor profiles relative to comparable comestibles that do not include 1,3-propanediol. Further 1,3-propanediol may be used in low concentrations, such as about 0.01 to about 5 wt. % in comestibles to effect modification of flavor profiles including perception of oxidized whole grain wheat flavors and the like.
US10201171B2	Flow circuit for carbonated beverage machine Systems, methods and cartridges for carbonating or otherwise dissolving gas in a precursor liquid, such as water, to form a beverage. Carbonating gas can be provided to a tank via the tank outlet, thereby purging at least a portion of a dispense line leading from the tank to a dispensing station. A single pump may be used to deliver liquid to the tank, e.g., for carbonation, and to pump pressurized air to dispense liquid from the tank. A water trap may help remove moisture from carbonating gas.
US10201168B2	Colicins for the control of EHEC The invention provides a method of preventing or reducing contamination of an object such as food with enterohaemorrhagic E. coli (EHEC), comprising contacting said object with colicin M or a derivative thereof.
US10201159B2	Fungicidal compositions A composition suitable for control of diseases caused by phytopathogens comprising a mixture of a compound of formula I with two compounds selected from compounds known for their fungicidal activity; and a method of controlling diseases on useful plants.
US10201152B2	Systems and methods for promoting biological responses in incubated eggs A system and method to promote biological responses within incubated eggs using lighting devices within an incubation chamber. A light supporting device is installed within the incubation chamber in spaced relation to an incubation device housing a plurality of eggs. The light supporting device is positioned to direct light at pre-determined wavelengths into the interior cavity of the incubation device to irradiate the plurality of eggs to promote a biological response within the eggs.
US10201149B2	Automated feeding device and method A feeder comprising: a base assembly and a rotatable housing, wherein the rotatable housing comprises: a pivotable portioning divider and an adjustment mechanism for adjusting the position of the pivotable portioning divider so that the pivotable portioning divider can be adjusted to vary an amount of food dispensed by the feeder.
US10201147B2	Garden bean named HMX4104 Novel garden bean cultivar, such as bean designated HMX4104 is disclosed. In some embodiments, the invention relates to the seeds of garden bean HMX4104, to the plants and plant parts of garden bean HMX4104, and to methods for producing a garden bean plant by crossing the garden bean HMX4104 with itself or another garden bean plant. The invention further relates to methods for producing other garden bean plants derived from the garden bean HMX4104.

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