| Document | Document Title |
|---|---|
| US10076711B2 |
Remote rendering server with broadcaster
Methods, systems, devices, and media for broadcasting a network game to a plurality of game spectators are provided. Game players are connected to a game server for participating in the network game. The game server executes a game program and generates game information for progressing the network game. A rendering server receives the game information from the game server, generates a player game screen for each of the game players, and generates a spectator game screen for the game spectators. The player game screen is transmitted to each of the game players for display by the game players. The spectator game screen is transmitted to a broadcaster, and the broadcaster transmits the spectator game screen to a display interface via a network. The display interface is accessible by each of the game spectators for viewing the spectator game screen. |
| US10076706B2 |
Gaming device with independent gesture-sensitive areas
A system that incorporates the subject disclosure may include, for example, a processor coupled to a memory storing instructions and to a near field sensor. Execution of the instructions can cause the processor to perform operations including defining a zone corresponding to a portion of an accessory comprising the sensor, detecting a gesture of an object in the zone by sensing the object with the sensor, determining that the gesture is a new gesture not previously associated with the zone and not previously associated with a gaming action controlling presentations produced by a gaming application, associating the gesture with the zone and with the gaming action, subsequently detecting the gesture in the zone, obtaining the gaming action associated with the gesture, and transmitting the gaming action to the gaming application. Other embodiments are disclosed. |
| US10076705B2 |
System and method for detecting user attention
A system and method for conditioning execution of a control function on a determination of whether or not a person's attention is directed toward a predetermined device. The method involves acquiring data concerning the activity of a person who is in the proximity of the device, the data being in the form of one or more temporal samples. One or more of the temporal samples is then analyzed to determine if the person's activity during the time of the analyzed samples indicates that the person's attention is not directed toward the device. The results of the determination are used to ascertain whether or not the control function should be performed. |
| US10076703B2 |
Systems and methods for determining functionality of a display device based on position, orientation or motion
A system for interfacing with an interactive program is provided, including: a computing device for executing the interactive program, the interactive program being stored on a memory, the computing device enabling user control and input; a display device for rendering image content associated with an interactive program, the display device being configured to be attached to the user; wherein the computing device is configured to receive data from an image capture device to determine and track a position of the display device; wherein the computing device is configured to define at least two interactive zones, each interactive zone being defined by a spatial region configured to change a function of the display device when the display device is moved between the at least two interactive zones; and wherein the computing device is configured to set the function of the display device. |
| US10076702B2 |
Setting up gaming sessions to reduce waiting time
A method for setting up a multiplayer gaming session, the method including: initiating a multiplayer gaming session by a host computing device; generating a list of games and selecting a game from the list of games on the host computing device; determining a list of invitees; generating a group of game configuration options for the selected game by the host computing device; sending a preliminary invitation to the multiplayer gaming session to each invitee of the list of invitees; launching the selected game on an invitee computing device of each invitee of the list of invitees; selecting game configuration options from the generated group of game configuration options; sending a final invitation to the multiplayer gaming session to each invitee of the list of invitees. |
| US10076701B2 |
Rim-mounted roulette ball launching system
A ball-launching system mounts to a top rim of a roulette wheel and positions a ball launcher configured to launch a roulette ball into the roulette wheel. The ball-launching system includes an outer jaw and an inner jaw, which clamp to the top rim. At least a part of a ball launcher extends into a concave bowl of the roulette wheel and facilitates launching the roulette ball directly into a ball track underneath the top rim within the concave bowl. |
| US10076699B1 |
Scoreboard apparatus for various sports games
A scoreboard apparatus for various sports games, comprising: a display module, an operation panel module, control module and a wireless communication module, wherein the control module displays the proceeding information about the corresponding sports game on the display module according to the preset sports game corresponding to the input signal of the selected operation switch unit, when the control module continuously receives the input signal from any one operation switch unit selected from the plurality of operation switch units provided in the operation panel. |
| US10076687B2 |
Golf club head with hosel support structure
A golf club head having a hosel, a hollow interior, and a support ring disposed within the hollow interior and at least partially encircling the hosel is disclosed herein. In particular, the present invention is directed to a fairway wood head comprising a body with a front wall, an upper opening, a return portion between the front wall and the upper opening, a hosel, an interface between the hosel and the heel side of the body, and a support ring, and a composite crown affixed to the body to close the upper opening and define a hollow interior, the support ring contained within the hollow interior and extending along the interface from a heel-most side of the body to the return portion and making contact with an inner surface of the front wall. The support ring reduces the stresses placed on, for example, the crown during hosel bending processes. |
| US10076686B2 |
Method for making a golf ball having a core containing fiber flock
A method for making a golf ball having fiber flock bonded to a core is provided. The fiber flock preferably has high color vibrancy to provide high quality aesthetics. Preferably, the fiber flock comprises fiber segments having a length less than one inch. The fiber segments may have substantially equal dimensions. In other instances, the fiber segments are of unequal dimensions. The golf ball includes a translucent cover layer surrounding the core. Thus, the fiber flock is visible from the exterior of the ball. Special decorative effects can be achieved using colored fiber flock and reflective particulate such as pearlescent pigment in the layers surrounding the core. |
| US10076683B2 |
Dimple patterns for golf balls
The present invention provides a method for arranging dimples on a golf ball surface in which the dimples are arranged in a pattern derived from at least one irregular domain generated from a regular or non-regular polyhedron. The method includes choosing control points of a polyhedron, generating an irregular domain based on those control points, packing the irregular domain with dimples, and tessellating the irregular domain to cover the surface of the golf ball. The control points include the center of a polyhedral face, a vertex of the polyhedron, a midpoint or other point on an edge of the polyhedron and others. The method ensures that the symmetry of the underlying polyhedron is preserved while minimizing or eliminating great circles due to parting lines. |
| US10076682B2 |
Dimple patterns for golf balls
The present invention provides a method for arranging dimples on a golf ball surface in which the dimples are arranged in a pattern derived from at least one irregular domain generated from a regular or non-regular polyhedron. The method includes choosing control points of a polyhedron, generating an irregular domain based on those control points, packing the irregular domain with dimples, and tessellating the irregular domain to cover the surface of the golf ball. The control points include the center of a polyhedral face, a vertex of the polyhedron, a midpoint or other point on an edge of the polyhedron and others. The method ensures that the symmetry of the underlying polyhedron is preserved while minimizing or eliminating great circles due to parting lines. |
| US10076681B2 |
Apparatus, system and method for power measurement
A power measurement device, which may be mounted to an inside area of a crank arm, includes processing circuitry within a housing. The processing circuitry is coupled with strain gauges mounted on the crank arm, and produces a power value that is wireless transmitted to a separate display that may receive and display power measurements. The housing may include a mounted portion and a cantilever portion where the mounted portion houses the processing circuitry and the cantilever portion houses batteries supply energy for the processing circuitry and other features. |
| US10076678B2 |
Exercise device
The present disclosure provides an exercise device having two tubular members and a tension member disclosed therein and coupled thereto, the tubular members designed to be pulled away from each other, and whereby the exercise device is also capable of being attached to one or more resistance bands. |
| US10076676B2 |
Flame resistant protective head shield
A flame resistant protective head shield includes a hollow body having a neck receptacle to facilitate the body being positioned around a neck of a wearer. The body has an exterior surface and an interior surface. The interior surface defines an interior cavity. An opening is provided in the exterior surface in communication with the interior cavity. A flexible flame resistant substrate is provided having a secured end and a free end. The secured end is secured to the body. The substrate is movable between a stored position within interior cavity and a deployed position in which the free end of the substrate extends through the opening and upwardly to cover a head of the wearer. A pressurized gas powered actuator is provided to move the substrate in a fraction of a second from the stored position to the deployed position. A sensor is provided for detecting a flash fire coupled to the actuator. Deployment of the substrate by the actuator is triggered by the sensor sensing a flash fire. |
| US10076668B2 |
System and method for nested neurostimulation
A method and system are provided to deliver nested stimulation to brain tissue of interest. The method and system set first parameters that define a carrier waveform. The method and system set second parameters that define a high frequency waveform, wherein at least one of the carrier waveform and high frequency waveform are defined to correspond to physiologic neural oscillations associated with the brain tissue of interest. The method and system operates a pulse generator to generate a nested stimulation waveform that combines the carrier waveform and high frequency waveform. The nested stimulation waveform has a plurality of pulse bursts. The method and system deliver the nested stimulation waveform through one or more electrodes to the brain tissue of interest. |
| US10076666B2 |
Systems and methods for treating post-traumatic stress disorder
One aspect of the present disclosure relates to a closed loop therapy system for treating post-traumatic stress disorder (PTSD) in a subject. The therapy delivery system can include a sensing component, a delivery component, and a controller. The sensing can be configured to detect at least one physiological parameter associated with PTSD. The delivery component can be configured for implantation on or about a pre-determined spinal simulation site. The pre-determined spinal stimulation site can include a spinal cord segment, or spinal nervous tissue associated therewith, other than a C1-C3 spinal cord segment or spinal nervous tissue associated therewith. The controller can be configured to automatically coordinate operation of the sensing and delivery components. The controller can also be configured to deliver an electrical signal to the delivery component to modulate activity at the pre-determined spinal stimulation site to effectively treat PTSD in the subject. |
| US10076664B1 |
Systems and methods for automatically programming patient therapy devices
Methods for automatically programming a signal generator in a patient therapy system and associated systems are disclosed. A representative method comprises retrieving data including therapy program parameters, level of efficacy, and medication use corresponding to a plurality of time periods; identifying from the data a target time period having a corresponding level of efficacy; determining from the data if medication was used during the target time period; determining from the data if medication was used during a prior time period immediately before the target time period; calculating a lead position confidence factor; and programming the signal generator to repeat therapy with the therapy program parameters corresponding to the target time period if the confidence factor is greater than a threshold value and medication was used during the prior time period and not during the target time period. |
| US10076659B2 |
Shielded implantable medical lead with guarded termination
Implantable medical leads include a shield that is guarded at a termination by having a first portion and a second portion of the shield, where the first portion is between a termination of the shield at the second portion and an inner insulation layer that surrounds the filars. The first portion may reduce the coupling of RF energy from the termination of the shield at the second portion to the filars. The first and second portions may be part of a continuous shield, where the first and second portions are separated by an inversion of the shield. The first and second portions may instead be separate pieces. The first portion may be noninverted and reside between the termination at the second portion and the inner layers, or the first portion may be inverted to create first and second sub-portions. The shield termination at the second portion is between the first and second sub-portions. |
| US10076658B2 |
Leadless cardiac stimulation systems
Various configurations of systems that employ leadless electrodes to provide pacing therapy are provided. In one example, a system that provides multiple sites for pacing of myocardium of a heart includes wireless pacing electrode assemblies that are implantable at sites proximate the myocardium using a percutaneous, transluminal, catheter delivery system. Also disclosed are various configurations of such systems, wireless electrode assemblies, and delivery catheters for delivering and implanting the electrode assemblies. |
| US10076656B2 |
Gait modulation system and method
An electrical stimulation orthosis and method therefor, the orthosis including: (a) an at least semi-rigid frame configured to substantially envelop a limb segment, the frame having at least one first complementary mechanical fastener associated therewith; (b) a surface electrical stimulation electrode assembly associated with, and supported by, the frame, the assembly having a surface stimulation electrode for contacting at least one stimulation point on the limb segment, the surface electrode assembly having an electrode base for electrically associating, via the frame, with a stimulator unit for providing a stimulation signal to the surface electrode, the electrode base having a top face for receiving the stimulation electrode, and a bottom face having at least one second complementary mechanical fastener, the first and second fasteners adapted for reversible attachment and detachment, at a plurality of locations on the frame, thereby enabling the electrical stimulation electrode assembly to be adjustably and reversibly positioned on the frame. |
| US10076653B2 |
Medical caps and methods of use
An intravascular port access device includes a first component having a chamber configured to attach reversibly to an intravenous line port. A second component reversibly attaches to the first component and contains a disinfecting agent and an applicator material. The second component is configured to be reversibly received over external surfaces of the intravenous line port. A method of cleansing an intravenous line port includes providing a port cleaning device having a first component with a chamber containing a first cleaning agent. A second component includes a second cleaning agent. A third component has a microbicidal agent and is reversibly attached to the first component. The second component is removed from the device, the external surfaces of the port are contacted with the second cleaning agent, the first cleaning agent is ejected from the chamber into the port, and the third component is used to cap the port. |
| US10076652B2 |
Method for ultrasound-mediated delivery system to monitor molecular penetration
Methods to use medical imaging to monitor the molecule penetration into CNS during ultrasound-mediated delivery are disclosed. The method states a two-step process to predict the amount of molecular penetration which is based on the observation of medical imaging. The first is to propose a unified exposure input to unify the exposure condition so as to build a transferred relation to imaging index. The second is to propose a unified imaging index to unify the imaging readout so as to build a reliable transferred relation to molecular concentration. Linking these two, the molecular penetration induced by ultrasound irradiation can be estimated from medical imaging with ultrasound exposure conditions and molecular sizes. |
| US10076651B2 |
Iontophoretic apparatus and method for marking of the skin
Embodiments provide apparatus and methods for producing markings in the skin. One embodiment provides an apparatus for marking the skin comprising a housing and reservoir for storing a skin colorant. An electrode is positioned within the housing so as to be electrically coupled to the colorant in the reservoir and is configured to be coupled to a current source and return electrode. A colorant applicator having at least one fluid pathway is coupled to a housing distal end. The applicator proximal end is positioned such that the fluid pathway is coupled with the reservoir. The applicator distal end applies colorant to the skin surface through the fluid pathway as the applicator is moved across the skin. The electrode delivers current from the current source to the skin to transport charged pigment elements of the colorant into the skin using an electromotive driving force to produce a marking in the skin. |
| US10076647B2 |
Systems and methods for the treatment of pelvic disorders including magnetic particulates
Systems and methods of localizing or delivery cells, biologics and/or drugs to a specific target area to treat pelvic health disorders are provided. A treatment composition including cells, biologics and/or drugs are associated with magnetic particulates, and the positioning of these materials is facilitated through use of a magnetic field-generating device that is configured to be placed on or into a pelvic anatomical structure. Certain embodiments directed to the treatment of ED in male patients can include a cell based therapy system. |
| US10076642B2 |
Conformable balloon devices
The present disclosure is directed toward a semi-compliant to non-compliant, conformable balloon useful in medical applications. Conformable balloons of the present disclosure exhibit a low or insignificant straightening force when in a curved configuration and at inflation pressures greater than 4 atm. Balloons of the present disclosure are constructed of material that can compress along an inner length when the balloon is in a curved configuration. In further embodiments, balloons of the present disclosure can be constructed of material that sufficiently elongates along an outer arc when the balloon is in a curved configuration. As a result, medical balloons, in accordance with the present disclosure, when inflated in a curved configuration, exhibit kink-free configurations and do not cause a significant degree of vessel straightening. |
| US10076641B2 |
Methods and systems for delivering substances into luminal walls
Angioplasty and other dilatation devices are provided with scoring elements which incorporate a drug to be delivered to a body lumen, typically a blood vessel. The scoring elements have drugs and other active substances coated over a portion thereof or incorporated within internal structure of the element so that the drug is released into the luminal wall closely associated diseased regions of the body lumen as the scoring structure is radially expanded into the wall. |
| US10076638B2 |
Steerable catheter with pull wire
In one representative embodiment, a steerable catheter device comprises a shaft comprising a proximal portion, a distal portion, and a pull-wire lumen that extends at least partially through the proximal and distal portions. A pull wire extends through the pull-wire lumen and has a proximal end portion and a distal end portion, wherein the distal end portion of pull wire is fixed to the distal end portion of the shaft. An adjustment mechanism is operatively connected to the proximal end portion of the pull wire and configured to increase and decrease tension in the pull wire to adjust the curvature of the distal portion of the shaft. An axially non-compressible pull-wire sleeve extends co-axially through the pull-wire lumen and over the pull wire. |
| US10076637B2 |
Catheter deflection actuator providing mechanical advantage
Deflection actuators configured to provide variable mechanical advantage and to optionally maintain a desired state of deflection are disclosed. Each deflection actuator may comprise a plurality of planar components, at least one of which is adapted to move relative to at least one other component. The planar components may comprise a channeled platform and a pivotable base mounted adjacent to the channeled platform. The platform may comprise a slider trough to slidably retain a slider. The base may have a cam arm pivotally connected to it and adapted to push a slider in its trough, whereby pivoting of the pivotable base relative to the channeled platform produces linear motion by the slider in its slider trough. The deflection actuator may also comprise a friction-lock knob, a knob receiver, and a pivot hub to selectably produce friction between various components to hold a catheter shaft in a desired state of deflection. |
| US10076635B2 |
Methods and devices for aseptic irrigation, urine sampling, and flow control of urine from a catheterized bladder
A connector system includes a catheter connector port to attach to a urinary catheter, a urine exit port to connect to a urine collection device, an irrigation port to receive an irrigation syringe, and an internal valve. The irrigation port includes a pliable membrane that has a self-sealing opening to allow a tip of the syringe to extend therethrough. The internal valve cooperates with the syringe to shut off flow of fluid to the urine exit port when the syringe is inserted and allow for flow of fluid to the urine exit port when the syringe is removed. A distance between a proximal surface of the membrane and a distal end of the internal valve is such that the tip of the syringe can extend from a proximal end of the self-sealing opening to the distal end of the internal valve. |
| US10076634B2 |
Multi-lumen device with non collapsable minor lumen
A method of producing a multi-lumen elongate body for a medical device. Unlike known methods requiring a solid core of material inserted into each lumen to maintain patency of the lumens during manufacture, the present method obviates the need for a solid core within one or more minor lumens, which saves cost and production complexity. One or more material overlay and mesh overlay steps may be used to produce the multi-lumen elongate body, but only the main lumen may include a solid core therein during all manufacturing steps. The one or more minor lumens may each be defined by a lumen tube having a sufficient stiffness to withstand external pressure during all manufacturing steps without the need for a solid core within. |
| US10076630B2 |
Device for performing regional anesthesia
An anesthetic administration device comprising an infusion device, which is in fluid connection with a regional anesthetic needle by means of a feed tube. The infusion device comprises one or more anesthetic flow devices capable of triggering forward flow, and optionally backward flow, of the local anesthetic through the regional anesthetic needle. Forward, and optionally backward flow, of the local anesthetic through the regional anesthetic needle is controlled by a controller that comprises one or more actuator switches. The one or more actuator switches are positioned on the device such that they may be operated by hand. |
| US10076629B1 |
Device for directing nebulized vapor
A device for directing a nebulized mixture includes a receiver, disposed at lower end of the device, to receive a nebulizer, an exhaust port to expel a nebulized mixture from the device, and a passage to transport the nebulized mixture from the nebulizer to the exhaust port. The device has an external shape of a novelty. |
| US10076626B2 |
System and methods for respiratory support using limited-leak cannulas
Various embodiments include systems and methods related to respiratory support delivered to infants using limited-leak cannulas. Various embodiments include a method of providing respiratory support to an infant. The method can include attaching a limited-leak cannula having prongs to an inspiratory port of a ventilator with connection tubing. The method can include selecting an operations mode on the ventilator that is specific for unidirectional flow limited-leak cannula use. The method can include initiating a calibration procedure with the prongs of the cannula freely exposed. The calibration procedure can include measuring the flow rate of gas through the connection tubing at a set pressure. The method can include setting monitoring parameters on the ventilator, initiating respiratory support by inserting the cannula prongs into the nares of the infant, and continuously monitoring the flow rate of gas through the limited-leak cannula. Other embodiments are also included herein. |
| US10076620B2 |
Anesthetic circuit having a hollow fiber membrane
An anesthetic circuit is provided for treating a patient. The anesthetic circuit includes a membrane having a plurality of hollow fibers. Also provided is a fluid separation apparatus connectable to an anesthetic circuit. In a further embodiment, a method is provided for anesthetic treatment of a patient. |
| US10076616B2 |
Oscillating positive expiratory pressure device
A respiratory treatment device comprising at least one chamber, a chamber inlet configured to receive air into the at least one chamber, at least one chamber outlet configured to permit air to exit the at least one chamber, and a flow path defined between the chamber inlet and the at least one chamber outlet. A restrictor member positioned in the flow path is moveable between a closed position, where a flow of air along the flow path is restricted, and an open position, where the flow of air along the flow path is less restricted. A vane in fluid communication with the flow path is operatively connected to the restrictor member and is configured to reciprocate between a first position and a second position in response to the flow of air along the flow path. |
| US10076614B2 |
Nasal delivery devices
A nasal delivery device for delivering substance to a nasal cavity of a subject comprises: a housing (15); a nosepiece (17) for fitting to a nasal cavity of the subject; a mouthpiece (19) through which the subject in use exhales; and a flexible coupling (20) which couples the mouthpiece to the housing, wherein the flexible coupling provides for asymmetric translation of the mouthpiece relative to the nosepiece. |
| US10076606B2 |
Insertion devices, insertion needles, and related methods
Insertion devices for installing insertion sets to a user, insertion needles, methods for loading insertion devices with insertion sets, methods for installing insertion sets, methods for instructing others how to load and/or install insertion sets, and certain aspects of insertion sets, including insertion needle hubs. |
| US10076602B2 |
Nasal douche with valve that can be actuated by respiratory air
A nasal douche having a valve, container part and cap part, wherein the container part serves to receive irrigation liquid and carries cap part. The cap part has a nose attachment with an outlet opening for irrigation liquid connected fluidically to interior of container part via discharge channel, wherein nose attachment is intended to be attached to a nostril of the user. The container part or cap part is assigned a mouthpiece for controlling the valve, wherein the valve is closed in a rest position and flow of irrigation liquid out through the nose attachment is thus suppressed, and wherein the valve can be brought to an open position, under the action of respiratory air when the user blows into the mouthpiece, and irrigation liquid thus flows out through the nose attachment, wherein respiratory air or ambient air flows into the container part to allow the outward flow. |
| US10076600B2 |
Targeted apheresis for the treatment of rheumatoid arthritis and immune disorders
This invention uses “Targeted Apheresis” to treat patients with Rheumatoid Arthritis and other autoimmune and inflammatory disorders. “Targeted Apheresis” is a process whereby only the pathogenic and pro-inflammatory elements associated with the disease symptoms are simultaneously and selectively removed from the blood by passing the blood through an extracorporeal affinity device containing selective binding agents. Removal of these pathogenic and pro-inflammatory elements will ameliorate the symptoms of autoimmune disease and may prolong the period of disease remission. |
| US10076599B2 |
Dry peritoneal dialysis concentrate system
A dry peritoneal dialysis (PD) concentrate system may be used in connection with a PD cycler. The dry PD concentrate system includes a concentrate container with at least two concentrate compartments, and at least one of the compartments contains a dry PD concentrate component. At least one of the concentrate compartments has a medical fluid outlet, and at least one of the concentrate compartments has a diluent inlet. |
| US10076594B2 |
Fluidic connector for negative pressure wound therapy
Disclosed herein are several embodiments of a wound treatment apparatus employing a fluidic connector for negative pressure wound therapy and methods of using the same. Some embodiments are directed to improved fluidic connectors for connecting to a wound site, for example a fluidic connector including a reinforcement, and methods of using the same. |
| US10076593B2 |
Pressure control algorithm for high resistance hardware
A pump and pump controller which uses an algorithm to quickly achieve and maintain a set pressure in a surgical site when high resistance hardware is being used is provided. The algorithm uses a gravity control type loop and uses pressure loss calculations to quickly respond to changing joint conditions. A method of using such a pump and pump controller is also provided. |
| US10076591B2 |
Absorbable coating for implantable device
The present invention provides an absorbable coating for an implantable device and the methods of making and using the same. |
| US10076578B2 |
Probes for imaging of hypoxia
Exemplary probes for detecting hypoxic cells and tissue have the structure of |
| US10076577B2 |
Compositions and methods for treating endocrine, gastrointestinal or autoimmune disorders
Recombinant cells and methods are provided that relate to the use of isolated, engineered recombinant cells to directly or indirectly treat diseases or disorders in a mammalian host such as endocrine, gastrointestinal or autoimmune disorders. A recombinant cell is provided that comprises a signal sequence and a promoter, wherein: the signal sequence is capable of regulating signal-dependent expression of a target nucleic acid in a host or is capable of regulating signal-dependent expression of a target nucleic acid in response to an environmental stimulus, the cell is derived from an enteric or a commensal bacterium, and the target nucleic acid encodes a mammalian factor that promotes normal functioning of a physiological process in the host or is effective in preventing onset, establishment, or spread of a non-infectious disease in the host. The recombinant cell is administered to the host to treat the disease or disorder. |
| US10076570B2 |
Composition for treating HBV infection
The present invention provides a composition comprising hepatitis B virus (HBV) component(s), and which may be either nucleic acid- or polypeptide-based as well as nucleic acid molecules and vectors encoding such HBV component(s). It also relates to infectious viral particles and host cells comprising such nucleic acid molecules or vectors. It also provides composition and kits of parts comprising such nucleic acid molecules, vectors, infectious viral particles or host cells and the therapeutic use thereof for preventing or treating HBV infections. |
| US10076569B2 |
Smallpox vaccine for cancer treatment
Disclosed herein are methods and compositions related to therapy for cancer. More specifically, the disclosed methods and compositions are related to the use of smallpox vaccine to induce an effective anti-tumor immune response. |
| US10076568B2 |
Recombinant herpes simplex virus 2 (HSV-2) vaccine vectors
Recombinant herpes simplex virus 2 (HSV-2) vaccine vectors, virions thereof, compositions and vaccines comprising such, and methods of use thereof are each provided. |
| US10076567B2 |
MPER-liposome conjugates and uses thereof
The present invention relates to peptides and compositions suitable for use in inducing anti-HIV-1 antibodies. The compositions comprise HIV-1 gp41 membrane proximal external region (MPER) peptide-liposome conjugates for induction of broadly reactive anti-HIV-1 antibodies. The invention also relates to methods of inducing neutralizing anti-HIV-1 antibodies using such compositions. |
| US10076566B2 |
Recombinant CDV compositions and uses thereof
The present invention provides vectors that contain and express in vivo or in vitro CDV polypeptides or antigens that elicit an immune response in animal against CDV, compositions comprising said vectors and/or CDV polypeptides, and methods of vaccination against CDV. The invention further provides methods for inducing an immunogenic or protective response against CDV and other canine virus, as well as methods for preventing or treating CDV and other canine virus or disease state(s) caused by CDV and other canine virus. |
| US10076565B2 |
Vaccines against multiple subtypes of influenza virus
An aspect of the present invention is directed towards DNA plasmid vaccines capable of generating in a mammal an immune response against a plurality of influenza virus subtypes, comprising a DNA plasmid and a pharmaceutically acceptable excipient. The DNA plasmid is capable of expressing a consensus influenza antigen in a cell of the mammal in a quantity effective to elicit an immune response in the mammal, wherein the consensus influenza antigen comprises consensus hemagglutinin (HA), neuraminidase (NA), matrix protein, nucleoprotein, M2 ectodomain-nucleo-protein (M2e-NP), or a combination thereof. Preferably the consensus influenza antigen comprises HA, NA, M2e-NP, or a combination thereof. The DNA plasmid comprises a promoter operably linked to a coding sequence that encodes the consensus influenza antigen. Additionally, an aspect of the present invention includes methods of eliciting an immune response against a plurality of influenza virus subtypes in a mammal using the DNA plasmid vaccines provided. |
| US10076564B2 |
Bacterial artificial chromosomes
The invention relates to the use of a bacterial artificial chromosome (BAC) for the preparation of a vaccine, wherein the BAC comprises an inducible bacterial ori sequence for amplification of the BAC to more than 10 copies per bacterial cell. Plus a viral expression cassette comprising a cDNA of an attenuated RNA virus genome and comprising cis-regulatory elements for transcription of said viral cDNA in mammalian cells and for processing of the transcribed RNA into infectious viral RNA. |
| US10076562B2 |
Methods for treating plague
Provided herein are methods for using compositions that include a fusion protein having a YscF protein domain, a mature F1 protein domain, and a LcrV protein domain. In one embodiment the composition is used to confer immunity to plague, such as pneumonic plague, caused by Yersinia pestis. In one embodiment, the composition is administered to a mucosal surface, such as by an intranasal route. In one embodiment, the administration to a mucosal surface includes a vector that has a polynucleotide encoding a fusion protein, where the fusion protein includes a YscF protein domain, a mature F1 protein domain, and a LcrV protein domain. The administration is followed by a second administration by a different route, such as an intramuscular route. The second administration includes a fusion protein having the same three domains, and in one embodiment the fusion protein is the same one administered to a mucosal surface. |
| US10076561B2 |
Vectors for transforming Mycoplasma hyopneumoniae, transformed M. hyopneumoniae strains, and use thereof
The present invention relates to mutant strains of Mycoplasma hyopneumoniae and to a method for preparing them. It also relates to carrier vectors which are used in said method, to vaccine compositions and to vaccination kits comprising the compositions against porcine enzootic pneumonia and other swine diseases. It also relates to the use of M. hyopneumoniae as a host for expressing recombinant proteins and other DNA sequences of interest. |
| US10076559B2 |
Preparation and composition of inter-alpha inhibitor proteins from blood
The present invention generally provides processes for purification of Inter-alpha inhibitor proteins (IαIp) and compositions thereof from blood. |
| US10076557B2 |
Botulinum toxin therapy for skin disorders
Methods for treating skin disorders by local administration of a Clostridial toxin, such as a botulinum toxin, to a patient with a skin disorder. |
| US10076556B2 |
Methods for inhibiting tumor growth
Methods of inhibiting or reducing tumor metabolism and growth are disclosed. A composition containing oxygen scavenging membrane fragments is administered within a tumor to create a hypoxic environment. This interferes with tumor growth and metabolism, and can lead to tumor death. |
| US10076555B2 |
Methods of inducing melanogenesis in a subject
Described herein are methods and compositions for inducing melanogenesis in a human subject. The method comprises administering to a subject an alpha-MSH analogue, in an effective amount and time to induce melanogenesis by the melanocytes in epidermal tissue of subject without inducing homologous desensitization of the melanocortin-1 receptors. |
| US10076554B2 |
FGF21-FC fusion proteins for treating metabolic disorders
The invention relates to the identification of fusion proteins comprising polypeptide and protein variants of fibroblast growth factor 21 (FGF21) with improved pharmaceutical properties. Also disclosed are methods for treating FGF21-associated disorders, including metabolic conditions. |
| US10076553B2 |
Dietary product intended for the prevention of cardiometabolic risk
A dietary product for preventing cardiometabolic risk in humans, in particular for reducing visceral fat and deep subcutaneous fat, includes in particular a mixture of: a whey hydrolysate having a molecular weight of between 200 and 10,000 daltons, an isolate and/or concentrate of whey, and calcium caseinate. |
| US10076551B2 |
Method for treating interstitial lung disease
A method of treating an interstitial lung disease comprises providing tea tree oil in a range of approximately 20%-60% by volume; providing aloe vera in a range of approximately 20% to 60% by volume; providing vinegar in a range of approximately 20% to 60% by volume; combining the tea tree oil, the aloe vera and the vinegar together; placing the combination of the tea tree oil, the aloe vera and the vinegar in a humidifier; and placing a diluent in the humidifier. |
| US10076545B2 |
Pharmaceutically compatible method for purifying intact bacterial minicells
The present invention provides a method for purifying bacterial minicells that involves subjecting a sample containing minicells to density gradient centrifugation in a biologically compatible medium. The method optionally includes a preliminary differential centrifugation step and one or more filtration steps. The invention also provides a method for purifying bacterial minicells in which a sample containing minicells is subjected to a condition that induces parent bacterial cells to adopt a filamentous form, followed by filtration of the sample to separate minicells from parent bacterial cells. The inventive methods optionally include one or more steps to remove endotoxin from purified minicell preparations, and/or treatment of purified minicell preparations with an antibiotic. Additionally, the invention provides purified minicell preparations, prepared according to the foregoing methods, and containing fewer than about 1 contaminating parent bacterial cell per 107, 108, 109, 1010, or 1011 minicells. |
| US10076544B2 |
Differentiation of human embryonic stem cells
The present invention provides a method for lowering blood glucose levels in an animal by transplanting a population of pancreatic endocrine precursor cells into an animal. |
| US10076543B2 |
Xenograft soft tissue implants and methods of making
The present application is directed to the field of implants comprising soft tissue for use in implantation in humans. The soft tissue implants of the present application are preferably obtained from xenograft sources. The present application provides a chemical process that sterilizes, removes antigens from and/or strengthens xenograft implants. The present techniques yield soft tissue implants having superior structural, mechanical, and/or biochemical integrity. The present application is also directed to processes for treating xenograft implants comprising soft tissues such as dermis, and to implants produced by such processes. |
| US10076540B1 |
Medication enhancement using hydrogen
Embodiments described herein generally relate to medicinal compositions (e.g., compositions comprising an active pharmaceutical agent) such as those comprising liquid hydrogen and/or hydrogen gas. In certain embodiments, the composition comprises hydrogen and/or noble gas(es) in a medicinal composition, for example, within the aqueous phase (e.g., dissolved). For example, in some cases, the medicinal composition may comprise an active pharmaceutical ingredient and hydrogen (H2) and/or noble gas(es). The noble gas may be, for example, xenon, argon, or the like. In some embodiments, the hydrogen and/or the noble gas(es) may infuse with the composition (e.g., such that at least a portion of the hydrogen gas and/or noble gas(es) is dissolved within the composition). Such compositions comprising hydrogen gas and/or noble gas(es) may be useful, for example, for the treatment of animal and human diseases, for improvement in athletic performance, for the enhancement of the overall health of a subject, or the like. Such compositions and/or liquids described herein may be administered (e.g., orally, intravenously, inhaled) to/by a subject. |
| US10076539B2 |
Pharmaceutical use of potassium hydroxide
This relates to the pharmaceutical use of KOH, in forms of topical, oral drugs or intravenous drip, prepared for treating high blood uric acid, especially gout. The external application refers to footbath in soaking solution or embrocation on attack position. The action of the drugs is also to promote the excretion of uric acid. Compared with colchicine and other drugs, KOH has three notable features. First, it takes effect quickly. No matter being applied by footbath, oral or embrocation, it can relieve symptoms within ten minutes, and the pain during gout attack will be significantly reduced. Second, it takes curative effect quickly. After application of the drugs for 2-3 consecutive days, gout symptoms will completely disappear. Third, it has no side effects. In one respect, with a low concentration, the KOH will not corrode the skin. In a further respect, potassium ion itself is diuretic and it has no harm to kidney. |
| US10076536B2 |
Oligonucleotide analogues targeting human LMNA
Provided are LMNA-targeted antisense oligonucleotides for reducing expression of one or more aberrantly spliced LMNA mRNA isoforms that encode progerin. |
| US10076535B2 |
Use of CPG oligonucleotides co-formulated with an antibiotic to accelerate wound healing
Pharmaceutical compositions are provided that include an antibiotics, but that include ingredients that counteract the effect of that antibiotic on wound healing, without altering the bactericidal properties of the antibiotic. These pharmaceutical compositions include an effective amount of 1) an imidazoquinoline having toll-like receptor 7 (TLR7) ligand activity, 2) an immunostimulatory K-type CpG oligodeoxynucleotide (ODN) comprising an unmethylated CpG motif, 3) an antibiotic, and 4) a surfactant, wherein the composition is formulated for topical administration. Methods for accelerating wound healing are also provided. These methods include topically administering the disclosed compositions. The wound can be in the skin or in the eye. |
| US10076532B2 |
Acyclic nucleoside phosphonate diesters
The present disclosure relates, inter alia, to compositions and methods for treating viral diseases and cancer. There are disclosed lipophilic antiviral and anticancer acyclic nucleoside phosphonate diesters, preparation thereof, and methods of using the compounds to treat viral diseases and cancer. |
| US10076531B2 |
Dialysis solution, use of a dialysis solution and chemical compound
The present invention relates to a dialysis solution having at least one osmotic agent, wherein the osmotic agent is starch propylphosphonate. |
| US10076530B2 |
Lipid compositions with high DHA content
The invention provides lipid compositions comprising phospholipids having a high docosahexaenoic acid (DHA) content, which compositions are preferably extracted from natural sources. The lipid compositions are excellent sources of highly bioavailable DHA and they can be used in oral delivery vehicles, dietary supplements, functional foods, and the like. |
| US10076529B1 |
Small molecule inhibitors of influenza A RNA-dependent RNA polymerase
Compositions, compounds, and methods with significant antiviral effect against RNA viruses and especially orthomyxoviruses are contemplated, and target the viral promoter that is formed by the 5′ and 3′-UTR sequences of the viral genome. |
| US10076525B2 |
Sex steroid precursors alone or in combination with selective estrogen receptor modulators for the prevention and treatment of dyspareunia in postmenopausal women
Novel methods for treating or reducing the likelihood of acquiring vaginal dysfunctions, more particularly vaginal dryness and dyspareunia, leading to sexual dysfunction and low sexual desire and performance, in susceptible warm-blooded animals including humans involving administration of a sex steroid precursor. Further administration of estrogen or selective estrogen receptor modulator, particularly those selected from the group consisting of Raloxifene, Arzoxifene, Tamoxifen, Droloxifene, Toremifene, Iodoxifene, GW 5638, TSE-424, ERA-923, and lasofoxifene, and more particularly compounds having the general structure: is specifically disclosed for the medical treatment and/or inhibition of development of some of these above-mentioned diseases. Pharmaceutical compositions for delivery of active ingredient(s) and kit(s) useful to the invention are also disclosed. |
| US10076520B2 |
Use of tyrosine kinase inhibitor in cancer treatment
The present invention provides methods for reducing apoptosis of non-cancerous cells during a cancer treatment and beneficial effects associated with reducing such apoptosis. In particular, methods of the invention comprise administering a tyrosine kinase inhibitor to a cancer patient who is undergoing cancer treatment in order to reduce apoptosis of non-cancerous cells. |
| US10076517B2 |
Methods and pharmaceutical compositions for the treatment of fibrosis
The present invention relates to methods and pharmaceutical compositions for the treatment of fibrosis. In particular, the present invention relates to a method of treating fibrosis in a subject in need thereof comprising administering the subject with a therapeutically effective amount of at least one monoacylglycerol lipase (MGL) inhibitor. |
| US10076513B2 |
Pharmaceutical compositions of 3-(6-(1-(2,2-difluorobenzo[D][1,3]dioxol-5-yl) cyclopropanecarboxamido)-3-methylpyridin-2-yl) benzoic acid and administration thereof
A pharmaceutical composition comprising Compound 1, (3-(6-(1-(2,2-difluorobenzo[d][1,3]dioxol-5-yl) cyclopropanecarboxamido)-3-methylpyridin-2-yl)benzoic acid), and at least one excipient selected from: a filler, a diluent, a disintegrant, a surfactant, a binder, a glidant and a lubricant, the composition being suitable for oral administration to a patient in need thereof to treat a CFTR mediated disease such as Cystic Fibrosis. Methods for treating a patient in need thereof include administering an oral pharmaceutical formulation of Compound 1 to the patient. |
| US10076508B2 |
Pharmaceutical compositions for inhibiting antibiotic-resistant microorganisms and uses thereof
This invention provides an antibiotic drug for inhibiting drug-resistant microorganisms. The antibiotic drug comprises Fmoc-Ala-OPfp, and not only has non-cytotoxic for normal human cell but also can inhibit drug-resistant microorganisms. |
| US10076501B2 |
Use of polymeric excipients for lyophilization or freezing of particles
Provided herein are use of polymeric excipients, specifically polyvinyl alcohols, optionally in conjunction with sugars, as cryoprotectants to prevent aggregation of PEG-containing particles. Also provided are PEG-containing particles comprising such polymeric excipients. |
| US10076498B2 |
Tamper resistant dosage forms
The present invention relates to pharmaceutical dosage forms, for example to a tamper resistant dosage form including an opioid analgesic, and processes of manufacture, uses, and methods of treatment thereof. |
| US10076497B2 |
Pharmaceutical formulation containing gelling agent
Disclosed in certain embodiments is a controlled release oral dosage form comprising a therapeutically effective amount of a drug susceptible to abuse together with one or more pharmaceutically acceptable excipients; the dosage form further including a gelling agent in an effective amount to impart a viscosity unsuitable for administration selected from the group consisting of parenteral and nasal administration to a solubilized mixture formed when the dosage form is crushed and mixed with from about 0.5 to about 10 ml of an aqueous liquid; the dosage form providing a therapeutic effect for at least about 12 hours when orally administered to a human patient. |
| US10076496B2 |
Engineering of polymer-stabilized nanoparticles for drugs with Log P values below 6 by controlled antisolvent precipitation
The present invention provides organic nanoparticles that include a molecule having a Log P value of about 3 or above, an amphiphilic diblock copolymer or a surfactant, and a pharmaceutically-acceptable hydrophilic polymer. The present invention also provides methods of making these nanoparticles, e.g., by flash nanoprecipitation, with control over particle size and surface properties. The methods of the present invention provide a means for co-precipitating a water-insoluble compound with an amphiphilic stabilizer within a few milliseconds. The nanoparticles of the present invention exhibit high drug loading, e.g., 50% w/w, and can be produced with a mean particle size less than 200 nm and with a narrow particle size distribution. |
| US10076495B2 |
Structures for transdermal drug delivery
A preparation for the transdermal delivery of a biologically active substance into the body of a patient comprises particles of a formulation comprising the active substance. The particles are irregular in size and shape and may be produced by a low cost manufacturing method such as grinding from a thin film. The particles are angular, i.e. they have sharp edges and corners that allow them to penetrate the outer layer of the skin when subjected to pressure from a roller or an array of blunt-tipped microstructures. Sucrose may be used as an excipient with the active substance to form suitably rigid and angular particles. |
| US10076494B2 |
Stable orally disintegrating pharmaceutical compositions
Described herein are stable orally disintegrating tablets containing a proton pump inhibitor, methods for making the same, and methods for treating subjects in need thereof. In particular, the orally disintegrating tablets are composed of a plurality of coated units admixed with a disintegrant that demonstrate decreased friability and increased hardness. |
| US10076488B2 |
Long-lasting powder essence composition with improved coloring and skin feeling and preparation method thereof
The present invention relates to a long-lasting powder essence composition with improved coloring and skin feeling and its preparation method. The powder essence composition is a high-fitting coloring powder not likely to smear or wear off. The composition turns into liquid the moment it is rubbed on the skin to offer a natural color tone like water color, keeps the color clear without getting cakey even when it is reapplied multiple times, and delivers a clearer color as it glides on the skin to break powder and water particles. The powder essence composition according to the present invention is also a powder emulsion, which makes the skin feel light and hydrated rather than sticky or stuffy when applied to the skin and stays long due to its water-resistant function. In addition, the powder essence composition according to the present invention contains different functional moisturizing agents to provide plenty of nourishment when applied to the skin. The composition makes the skin feel fresh and hydrated rather than stuffy or heavy, lightly sinks into the skin like nothing is applied on the skin, to display a strong tint function, stays long just with one touch and has a good water-resistant effect, so it does not bleed when in contact with water. |
| US10076474B2 |
Aerosol antiperspirant compositions, products and methods
An aerosol antiperspirant composition is provided. The aerosol antiperspirant composition includes a propellant having a concentration from 70% to 90% by weight of the aerosol antiperspirant composition and an antiperspirant composition. The antiperspirant composition includes one or more liquid materials, wherein the one or more liquid materials comprise one or more non-volatile silicone fluids having a concentration from 40% to about 70% by weight of the antiperspirant composition, an antiperspirant active particulate, one or more non-antiperspirant active particulates that are substantially inert, wherein the one or more non-antiperspirant active particulates have a concentration from 10% to 30% by weight of the antiperspirant composition. The antiperspirant composition has a total particulate concentration from 30% to about 60% by weight of the antiperspirant composition. |
| US10076467B2 |
Assembly for coupling an adaptor with a medical container
An assembly including a connecting member to be mounted on a first medical container, an adaptor including a gripping member to be mounted on a second medical container, a pierceable elastomeric piece, fixed with respect to the gripping member, a protecting envelope comprising a rigid shell substantially surrounding the connecting member and the adaptor in a storage position of the assembly, in which the connecting member is separate from the adaptor. The rigid shell is closed by a removable film. The assembly further comprises a first engagement portion for preventing the connecting member from escaping from the rigid shell when the film is removed. Also, a kit including such an assembly and first and second medical containers. |
| US10076460B2 |
Method and apparatus for improving human balance and gait and preventing foot injury
A method and wearable system and for enhancing human balance and gait and preventing foot injury through neurological stimulation of the foot and the ankle. Subthreshold stimulation for neurosensory enhancement is provided via electrodes or vibrational actuators, or combination thereof, disposed in or on a wearable a platform, such as an insole, sock shoe, removable shoe insert, or applied without the support of a platform, to the skin surface of an individual. Suprathreshold stimulation for therapeutic purposes, such as improving blood flow, is also provided by the vibrational actuators. The actuators and electrodes are driven by bias signals generated by a bias signal generator that is coupled to a controller. The signal generator under the control of the controller is adapted to generate a non-deterministic random signal, a repetitive pattern or series of patterns. The controller optionally includes a communication port for interfacing with an external computer for purposes of optimizing and programming the controller. The wearable system is powered by a power source. |
| US10076459B2 |
Methods and systems for monitoring lift usage
Methods and systems for lift monitoring are described. In one embodiment, a first operation signal may be received from a first relay coupled to an electro-mechanical patient lift when the electro-mechanical patient lift is being operated in a first position. A second operation signal may be received from a second relay coupled to the electro-mechanical patient lift when the electro-mechanical patient lift is being operated in a second position. A determination of whether a lift qualification threshold is met may be based on the receiving of the first operation signal and the second operation signal. An occurrence of a lift may be recorded when a determination is made that the lift qualification threshold is met. Additional methods and systems are disclosed. |
| US10076451B2 |
Moiré effect laminates and methods for making the same
A laminate comprises a first layer comprising a plurality of lower opacity zones positioned within a higher opacity zone is provided. The plurality of lower opacity zones form a first pattern. The laminate comprises a second layer comprising a second pattern. The laminate comprises a non-joined span of the first and second layers having a dimension of at least about 20 mm. A first portion of the second pattern is visible through at least some of the plurality of lower opacity zones when the first layer, within the non-joined span, is in a first position relative to the second layer, within the non-joined span. A second portion of the second pattern is visible through at least some of the plurality of lower opacity zones when the first layer, within the non-joined span, is in a second position relative to the second layer, within the non-joined span. |
| US10076448B2 |
Tarsus eyelid patch
A Tarsus Eyelid Patch and method to hold a superior tarsus in a closed position to heal or treat defects on the eye surface is presented. A perforated mesh device includes a medial edge, a lateral edge, a superior edge, an inferior edge, and an adhesive surface, wherein the perforated mesh device is a non-rigid device. The adhesive surface of the superior edge is configured to attach to a region below an eyebrow and on the superior tarsus forming a convex region and further configured to attach to and conform to the superior tarsus when the superior tarsus is in the closed position forming a concave region when the adhesive surface of the inferior edge is to attached to a lower portion of the superior tarsus when the superior tarsus is in the closed position. |
| US10076444B2 |
Steerable laser probe
A steerable laser probe may include an actuation structure, a nosecone fixed to the actuation structure by one or more links and one or more link pins, a housing tube having a first housing tube portion with a first stiffness and a second housing tube portion with a second stiffness, and an optic fiber disposed in the housing tube and the actuation structure. A compression of the actuation structure may be configured to gradually curve the housing tube and the optic fiber. A decompression of the actuation structure may be configured to gradually straighten the housing tube and the optic fiber. |
| US10076441B2 |
Devices for cooling the nasal cavity
A method for cerebral cooling is described using a cooling assembly, which includes first and second elongate tubular members adapted for insertion into a nasal cavity of a patient through the patient's nostrils. The elongate tubular members each have a proximal end, a distal end, a lumen extending therebetween, and a plurality of ports in fluid communication with the lumen. The cooling assembly also includes a manifold and a reservoir, which contains a pressurized fluid that includes a propellant having a boiling point less than 22° C. The elongate tubular members are inserted into the nasal cavity through the patient's nostrils and pressurized fluid is delivered onto a surface of the nasal cavity by infusing the pressurized fluid from the reservoir through the manifold, into the lumens and through the plurality of ports of the first and second elongate tubular members. |
| US10076439B2 |
Fecal matter containment device
A single use device for capturing fecal matter excreted from the anus of a user. The device includes a flexible fecal matter container having a closed end and an opening that is in fluid communication with a volume enclosed by the flexible container. An adhesive is disposed about the opening of the flexible container and has a first side that is secured to the flexible container. A second side of the adhesive is constructed to be removably applied to the epidermis of the user proximate an anal opening of the user. The adhesive is shaped to cooperate with the epidermis to circumscribe the anus in a sealed manner without interfering or overlapping anatomy associated with urinary function or medical devices, such as a catheter, associated therewith. |
| US10076438B2 |
Human waste collection bag
A human waste collection bag comprising a front wall facing away from the skin and a rear wall facing towards the skin, the walls being made from flexible material, the bag having an inlet opening for receiving human waste, wherein at least the front wall has a gray or grayish color that provides low contrast to the wearer's skin. |
| US10076436B2 |
Wearable foot garment
Various implementations include a wearable foot garment that includes a forefoot portion, a midfoot portion, and an ankle portion. The midfoot portion includes two high compression zones and a reduced compression zone between the high compression zones. The first high compression zone is configured for providing compression in a radially inward direction toward the wearer's foot adjacent a proximal end of the wearer's plantar aponeurosis. The second high compression zone is configured for providing compression in a radially inward direction toward the wearer's foot adjacent distal ends of metatarsals of the wearer. The compressive strength in the high compression zones is greater than the compressive strength in the reduced compression zone. In some implementations, the ankle portion and midfoot portion define a heel opening, and the forefoot portion includes a plantar surface area on which an adhesive film is disposed for increasing the friction contact of the forefoot portion. |
| US10076434B2 |
Stent delivery system
An intraluminal apparatus for delivering a self-expanding stent which extends along a longitudinal axis from a proximal side to a distal side. It comprises in delivery configuration (a) a retracting sheath having a lumen along its longitudinal axis and slidably covering a stent receiving region at the distal end of the lumen, (b) an inner shaft longitudinally disposed in the intraluminal apparatus, at least a distal portion of the inner shaft being disposed within the sheath, (c) the self-expanding stent in a compressed state disposed within the stent receiving region of the lumen, (d) a holding means delimitating an inner cavity, disposed adjacent to a proximal side of the stent in the sheath, the proximal end of the holding means being permanently joined to the inner shaft, and (e) a handling means placed towards the proximal side of the intraluminal apparatus, able to displace longitudinally the retracting sheath with respect to the inner shaft. When the intraluminal apparatus is in a delivery configuration, the distal portion of the holding means is disposed around the proximal portion of the stent and defines an overlapping region of the holding means and the stent. The ratio L(10)/L(2)Comp of the length of the overlapping region, L(10), to the length of the self-expanding stent, L(2)Comp, in their compressed state is at least 5% and at most 30%. |
| US10076430B2 |
Devce with tensioners
This disclosure provides for a medical device to be implanted in the vasculature and a method for treatment in the vasculature. The device has an outer layer of a first material and an inner layer of a second material attached to the outer layer. The inner layer further has a plurality of elastomeric tensioners. If the device experiences relaxation, resulting in a decreased radial force against the vessel wall, the elastomeric tensioners may provide a contraction force to the inner layer and the outer layer, resulting in a maintained radial force on the vessel wall. |
| US10076424B2 |
Impaction systems
Methods of inserting and retaining interbody fusion material are disclosed. In some embodiments, the methods include inserting an anchored implant comprising a bone anchoring portion and an engagement portion. A method may also include inserting at least one bone fusion material within a disc space between two adjacent vertebral bodies. In some embodiments, a method includes driving the bone anchoring portion into an outer surface of at least one of the adjacent vertebral bodies and recessing the bone anchoring portion within the outer surface of the at least one adjacent vertebral body. |
| US10076418B2 |
Modular femoral provisional
A provisional prosthetic system that replicates the characteristics of a corresponding, nonprovisional femoral prosthesis. The provisional prosthetic system may include a frame component and a shell component. The frame component of the provisional prosthetic system may be configured to be attached directly to a resected femur. In one exemplary embodiment, the frame component is impacted onto the resected femur to firmly seat therewith. Once the frame component is secured to the resected femur, a shell component of the provisional prosthetic system may be positioned on and secured to the frame component. In one exemplary embodiment, the frame component is made from a metallic material. This allows for the frame component to maintain the rigidity necessary to facilitate proper trialing. In another exemplary embodiment, the shell component is a plastic. |
| US10076413B2 |
Adjustable implant system
Systems and methods treat a heart valve using a magnetically adjustable annuloplasty ring attached to or near a cardiac valve annulus. A changing magnetic field may be used to selectively increase or decrease a circumference of, or otherwise modify the shape of, the implanted annuloplasty ring. The adjustable annuloplasty ring includes a tubular body member, one or more adjustable members, and an internal magnet within the tubular body member. The tubular body member and the one or more adjustable members form a ring shape. The internal magnet is configured to rotate in response to a rotating external magnetic field. The internal magnet is coupled to the one or more adjustable members to change a dimension of the ring shape as the internal magnet rotates. A system for treating a heart valve may include an external adjustment device having one or more external magnets to generate the rotating external magnetic field. |
| US10076412B2 |
Expandable member for deploying a prosthetic device
An apparatus and method for delivering a prosthetic device through the vasculature of a patient includes a radially expandable member coupled to the distal end of an elongate shaft. The expandable member has an open frame configuration and an outer mounting surface for mounting the prosthetic device in a collapsed state thereon. The expandable member expands radially outwards from a first configuration to a second configuration to expand a prosthetic device mounted thereon. |
| US10076409B2 |
Vision system responsive to a presence of a wearable ophthalmic element
Described embodiments include a vision system and a method. A vision system includes a sensor circuit configured to detect a presence of a wearable ophthalmic element in an optical path incident on a vision correction device. The vision correction device includes an electronically controllable vision parameter and configured to be placed in an eye of a human subject. The vision system includes a controller circuit coupled to the vision correction device and configured to change the electronically controllable vision parameter of the vision correction device at least partially in response to the detected presence of the wearable ophthalmic element in the optical path. In an embodiment, the vision system includes the wearable ophthalmic element. In an embodiment, the vision system includes the vision correction device. |
| US10076401B2 |
Vein filter
A vessel filter movable between a collapsed position for delivery to the vessel and an expanded position for placement within the vessel, and having a filter portion having a converging region to direct particles toward the center. The filter portion converges into a tubular portion. The second region is flared in the expanded position to have a transverse dimension increasing in a direction away from the filter portion and includes a vessel engaging portion. The first region has a spacer to keep the filter more toward a center of a vessel, wherein in the collapsed position the spacer extends axially in an elongated position cranially of the cranial end of the filter and in the expanded position the spacer forms a looped region extending radially with respect to a longitudinal axis of the filter. The spacer has a first end attached to the internal surface of the tubular portion and extends within the tubular portion and emerges cranially from the tubular region to form the looped region. |
| US10076394B2 |
Method of treating urinary incontinence
A method of treating urinary incontinence is disclosed. The method includes guiding a tip of an introducer tool through a length of a soft tissue anchor and out of an end of the soft tissue anchor. The method includes pushing the tip of the introducer tool and the soft tissue anchor into tissue on a side of a urethra, penetrating the tissue with the tip of the introducer tool, and delivering the soft tissue anchor into the tissue. The method includes removing the tip of the introducer tool from the soft tissue anchor and allowing a plurality of projections connected to the soft tissue anchor to expand thus anchoring the soft tissue anchor in the tissue. |
| US10076389B2 |
Three-dimensional tooth modeling using a two-dimensional x-ray image
A processing device receives a 3D model including a 3D crown component from a scan and a 3D root component from a template. The processing device receives a 2D x-ray image of the at least one tooth and generates a scan model representing an initial estimate of the one or more parameters of an x-ray imaging device that created the 2D x-ray image. The processing device further generates a 2D contour of the at least one tooth based on projecting the 3D model onto a plane using the scan model. The processing device overlays the 2D contour onto the 2D x-ray image. The processing device further adjusts the 2D contour to cause a first crown component of the 2D contour to approximately align to a second crown component of the 2D x-ray image. The processing then calibrates the scan model based on data obtained from adjusting the two-dimensional contour. |
| US10076388B2 |
Method and device for the production of a dental prosthesis part
The method for the production of a dental prosthesis part comprises the provision (11) of a dataset (2) for a dental prosthesis part (6) for use in a CAD/CAM technique, the provision (12) of reference data (3) for optical properties of different dentin materials and translucent enamel materials for the dental prosthesis part (6) and a relationship (4) between said optical properties, the desired optical properties and the dimensions of the dental prosthesis part (6), the definition (13) of a first setpoint (S1) for the optical properties of a dentin region, the definition (14) of a second setpoint (S2) for the optical properties of an enamel region, the definition (15) of a third setpoint (S3) for a thickness of the enamel region of the dental prosthesis part (6), the selection and provision (16) of a dental prosthesis mold block (5) having a dentin region made from a material. |
| US10076380B2 |
Energy delivery devices and methods
This relates to methods and devices for achieving contact between the wall of a cavity or passageway and a medical device when used in tortuous anatomy. |
| US10076379B2 |
Electrosurgical instrument with removable components for cleaning access
A surgical instrument includes a handpiece, an elongate shaft assembly extending distally from the handpiece, an activation assembly, an end effector disposed at a distal end of the shaft assembly, and a firing beam. The handpiece comprises a cover operable to selectively expose an interior of the handpiece. The activation assembly is selectively coupleable with the handpiece and is operable to regulate the delivery of power to the end effector. The shaft comprises a selectively removable jaw assembly. The end effector has a pivoting jaw operable to pivot toward and away from the jaw assembly to thereby capture tissue. The jaw assembly and the pivoting jaw each comprise an electrode surface. The electrode surfaces are configured to seal the captured tissue by providing RF energy to the tissue. The firing beam is configured to sever the sealed tissue. |
| US10076376B2 |
Devices and methods for bending or cutting implants
Devices and methods for bending or cutting implants are disclosed herein. In some embodiments, an instrument can include a rotatable drive shaft that urges first and second portions of a modular bending or cutting template toward one another to bend or cut an implant disposed between the template portions. A linkage assembly can be included to provide a mechanical advantage in urging the template portions toward one another. In some embodiments, an instrument can include a rotatable drive shaft that, depending on direction of rotation, pushes or pulls a first modular template portion with respect to a second modular template portion to bend an implant disposed between the template portions in one direction or another direction. In some embodiments, an instrument can include a worm drive that rotates a cutting wheel with respect to a cutting plate to cut an implant inserted through openings formed in the cutting wheel and the cutting plate. |
| US10076375B1 |
Implantable device facilitating rotational-guided growth and method of use
An implantable device for controlling rotational growth is disclosed. The implantable device comprises a first screw and a second screw inserted using minimally invasive surgical procedures and positioned within holes created by guiding members. The first screw is positioned in an metaphyseal section and the second screw is positioned in a epiphyseal section in distal femur. The implantable device comprises a cable drawn through the first screw and the second screw. Further, the implantable device comprises a cotter or a thin screw inserted in the first screw to lock the cable. The implantable device modifies longitudinal growth and generates rotational movement due to torque generation, thereby promoting the rotational growth of the bone. |
| US10076369B2 |
Bone fastener for a spinal fixation assembly
An implantable cervical plate assembly includes a cervical plate, one or more bone fasteners. The cervical plate comprises an elongated asymmetric body having one or more through-openings extending from the front surface to the back surface of the elongated asymmetric body. The one or more bone fasteners are configured to be inserted through the one or more through-openings, respectively. The bone fasteners comprise a threaded main body and a head that includes one or more breakable structures configured to be broken when inserted into a groove and then unflex and remain captured within the groove. |
| US10076364B2 |
Minimal-profile anterior cervical plate and cage apparatus and method of using same
An apparatus and method for fusing cervical vertebrae is provided. The apparatus may include a plate configured to be affixed to at least two vertebrae, and at least two screws configured to affix the plate to an anterior surface of the at least two vertebrae, wherein when the plate is affixed to the at least two vertebrae, the plate is configured to be partially disposed in a disc space between the at least two vertebrae, and extend in an anterior direction beyond an anterior surface of the at least two vertebrae. |
| US10076359B2 |
Adjustable cannula systems and devices
Various adjustable cannula systems are provided. The systems can include an adjustable cannula capable of expansion and/or contraction having an elongate body with a distal end and a proximal end. The adjustable cannula can be coupled to an upper housing and a lower housing such that rotation of the upper housing results in expansion or contraction of the adjustable cannula. The adjustable cannula can also have a proximal end having a lumen larger than a distal end lumen. A plurality of flanges can be formed in the elongate body by a plurality of slits that span a majority of a length of the cannula, including along or proximate to its proximal end and distal end. |
| US10076354B2 |
Pixel array medical devices and methods
Systems, instruments or devices, and methods or procedures are described in which a scalpet array is applied to a target site with the use of a pattern. The scalpet array comprises scalpets positioned on a device. Skin pixels are incised at the target site via application of a load through the scalpet array. A recipient site is prepared by positioning the pattern at the recipient site and applying the scalpet array to generate skin defects. The incised skin pixels are applied at the skin defects of the recipient site. |
| US10076352B2 |
Implantation needle
A non-coring hair implantation needle is provided which provides for a smaller opening than a conventional hypodermic needle, and includes a bevel of shorter length. The needles are configured to provide a non-cutting feature, and aid in placement and retention of an implanted hair graft when the needle is withdrawn from the body surface. Furthermore, methods of fabricating needles includes bevels of shorter length and non-cutting features are disclosed. |
| US10076350B2 |
Tool bit of ultrasonic osteotome and ultrasonic osteotome including the same
Disclosed are a tool bit of an ultrasonic osteotome and an ultrasonic osteotome including the same, the tool bit comprising: an arbour (2); and an end portion (1) of the tool bit connected to a front end of arbour (2), wherein the end portion (1) of the tool bit has a hook-like shape and includes a hook tip (11), a hook handle (13), as well as a hook-shaped interconnecting piece (12) which is interconnected between the hook tip (11) and the hook handle (13). The hook handle (13) is connected with the arbour (2), and the inner side edge of the hook-shaped interconnecting piece (12) is tooth-like. With this ultrasonic osteotome, the cutting efficiency is high and surgery time is short, therefore the labour intensity of medical workers is decreased. Moreover, accurate positioning can be realized in cutting process with no skidding, so the chance of success of surgery can be improved. |
| US10076349B2 |
Ultrasonic surgical drill and associated surgical method
An ultrasonic surgical drill or drill bit includes a tubular member having a longitudinal axis of symmetry and a plurality of fins extending in longitudinal planes each containing the axis. In a surgical method utilizing the drill bit, one places a distal tip of the drill bit in contact with bone, presses the drill bit against the bone, and during that pressing of the drill bit, conducts ultrasonic vibrations into the drill bit. With the fins in contact with the bone, the drill bit is oscillated or angularly reciprocated about a longitudinal axis, so that the fins fragment bone material located between the fins. |
| US10076346B2 |
Complex wire formed devices
The devices and methods described herein relate to jointless construction of complex structures. Such devices have applicability in through-out the body, including clearing of blockages within body lumens, such as the vasculature, by addressing the frictional resistance on the obstruction prior to attempting to translate and/or mobilize the obstruction within the body lumen. |
| US10076345B2 |
Patellar clamping instrument
A patellar clamp and associated system and method for using the clamp are provided. A patellar clamp includes a pair of handles movably coupled together, a patella support portion connected to the pair of handles and configured to engage a first side of a patella, and a reamer guide configured to engage a second side of the patella. The patella support portion and the reamer guide each include a first pair of flanges configured to engage a first and second tendon associated with the patella. The reamer guide is configured to allow reaming and resurfacing the entire desired posterior articular surface of the patella in a single operation without readjusting the position of the reamer guide. |
| US10076340B2 |
Surgical tool system with a tool unit that includes a power generating unit and a battery and control module that is releasably attached to the tool unit for energizing and controlling the power generating unit
A battery and control module to which a powered surgical tool is releasably attached. Internal to the module there is: a cell for energizing the tool; a sensor for monitoring an operational state of the tool; a sensor for monitoring a trigger external to the module; and a control circuit. Based on the signals output by the sensors, the control circuit selectively applies energization signals from the cell to the power generating unit internal to the surgical tool. In some versions of the invention, the trigger is attached to the module. |
| US10076334B2 |
Surgical instrument and method for performing a resection
An end effector for use with a surgical instrument comprising an anvil shaft, a first anvil assembly disposed at a distal portion of the anvil shaft and a second anvil assembly mountable on the anvil shaft proximally of the first anvil assembly. Also, a method for performing a surgical procedure is provided including the steps of providing a surgical instrument including a first cartridge assembly and a first anvil assembly having an anvil shaft, approximating the first anvil assembly and first cartridge assembly and ejecting staples from the first cartridge assembly. The method further includes removing the first cartridge assembly from the tubular organ, and inserting a second anvil assembly into the tubular organ to engage the anvil shaft of the first anvil assembly and ejecting staples from a second cartridge assembly towards the second anvil assembly. |
| US10076331B2 |
Device and method for forming an anastomotic joint between two parts of a body
A device and method for forming an anastomotic joint between two parts of a human or animal body having a hollow connector with at least two proximal arms biased towards an open position; and at least two distal arms biased towards an open position, wherein in use when pressure is applied to the proximal arms to overcome the bias into a position in which the proximal arms are closer to each other; similarly pressure is applied to the distal arms to overcome the bias into a position in which the distal arms are closer to each other; the distal end can be pushed into a passage in the first human or animal body part until the distal arms are located in the first lumen of the first body part and released allowing the distal arms to move to the biased position to urge against the first lumen of the first body part; and the proximal end can be pushed into a passage in the second human or animal body part until the proximal arms are located in the second lumen of the second body part and released allowing the proximal arms to move to the biased position to urge against the second lumen of the second body part. |
| US10076329B2 |
Adjunct material to promote tissue growth in a colon
Adjunct material to promote tissue growth is provided. In general, an implantable adjunct can be configured to be applied to tissue by a surgical stapler in conjunction with staples. The adjunct can have one or more medicants releasably retained therein that are effective to provide a desired effect on tissue in-growth in a predetermined manner. One or more characteristics associated with the adjunct can be altered between various implementations to promote organized tissue remodeling in a desired manner during wound healing, such as by encouraging tissue growth to be in a certain direction and/or by discouraging tissue growth in a certain area and/or on a certain structure. |
| US10076326B2 |
Surgical stapler having current mirror-based motor control
A surgical stapler. The surgical stapler includes a drive system, an electric motor, a battery and a control system. The electric motor is mechanically coupled to the drive system. The battery is electrically couplable to the electric motor. The control system is electrically connected to the electric motor and includes an H-bridge circuit and a current mirror circuit. The H-bridge circuit includes a plurality of switching devices. The current mirror circuit is electrically connected to the H-bridge circuit. The control system is configured to control a force applied to the drive system based on a current measured at a node of the current mirror circuit. The node is electrically connected in parallel with the H-bridge circuit. |
| US10076323B2 |
Longitudinal needle passer
A device for passing a needle and suture longitudinally through a target tissue includes a proximal jaw including a proximal recess and a proximal retention mechanism for releasably engaging a first end of a needle received within the proximal recess and a distal jaw movably coupled to the proximal jaw such that the proximal and distal jaws are longitudinally movable relative to one another. The distal jaw includes a distal recess and a distal retention mechanism for releasably engaging a second end of the needle received within the distal recess. The proximal and distal jaws are movable between a first state, in which the proximal retention mechanism is in a locked configuration and the distal retention mechanism is in an unlocked configuration, and a second state, in which the proximal retention mechanism is in an unlocked configuration and the distal retention mechanism is in a locked configuration. |
| US10076322B1 |
Tissue button
A tissue button includes a body, a door, and a cross-pin that secures the door to the body. The door pivots relative to the body between an open position and a closed position. A first portion of a suture can be pulled when the door is in the open position, and a second portion of the suture cannot be pulled when the door is in the closed position. A cross-section of the cross-pin taken perpendicular to a longitudinal axis is non-circular. |
| US10076318B2 |
Apparatus and method for cardiac tissue modulation by topical application of vacuum to minimize cell death and damage
A method and apparatus are provided for treating cardiac tissue to modulate ischemic heart tissue with topical sub-atmospheric pressure to minimize cell death and damage. |
| US10076317B2 |
Endoscope apparatus
The endoscope is provided with the forceps elevator which is erectably provided in the distal end part of the insertion part of the endoscope and guides a treatment tool led out from the distal end part. The forceps elevator has an erecting motion range from a minimum angular position to a maximum angular position. If a state in which the treatment tool is not led out from the distal end part is assumed, the erecting operation lever for operating the movement of the forceps elevator has: a first operation range where the erecting operation lever is operated within the erecting motion range of the forceps elevator; and a second operation range where the erecting operation lever is operated beyond the first operation range. When the erecting operation lever is operated into the second operation range, the locking mechanism locks the movement of the erecting operation lever. |
| US10076314B2 |
Device for assaying analytes in bodily fluids
A device for determining the presence and/or quantity of one or more analytes in a sample of human body fluid has a container for receiving a sample of body fluid, with an interior that is delimited by a base and by a circumferential surface. It further comprises at least one test strip and a holding element for receiving and holding the one or more test strips. The holding element is designed such that it has a shape corresponding and adapted to the peripheral circumferential surface of the container. The device further comprises an elongate sampling element having an absorbent sampler that takes up the sample of body fluid and by means of which the sample of body fluid is transferred into the container. The sampling element can include an indicator strip for determining whether the amount of liquid sample sufficient for carrying out an assay. |
| US10076313B2 |
System and method for automatically adjusting beams to scan an object in a body
A method of scanning for an object using an adaptive scheduler starts with an electronic circuit (EC) receiving information associated with the object. A task list is then generated by the EC that includes at least one task action based on the information associated with the object. The at least one task action includes a beam firing required for the object to be scanned. The EC may signal based on the task list to a beamer to generate and send a signal to a probe unit to perform the beam firing. A receiver may receive and process a data signal from the probe unit and send the processed data signals to the EC. The EC may then analyze the processed data signal to determine if the object is identified using the processed data signal. Other embodiments are also described. |
| US10076307B2 |
Echogenic article with compound indentations
The present invention provides an article or an interface having a distribution of a first partially spherical indentation and at least a second partially spherical indentation contained within the first indentation to form a multi-component or “compound” shape that is referred to as a “compound” or “nested” dimples or indentations. These compound dimples or indentions may be concentric and are etched or otherwise formed into a surface or interface of an article to enhance the ultrasonic imaging. Exemplary articles may be needles of the type used to conduct nerve blocks or the interface may be the surface of such a needle, cannula, catheter, catheter tip or similar article. |
| US10076305B2 |
Composition for ultrasonic probe, and silicone resin for ultrasonic probe
A composition for an ultrasonic probe contains: a mixture including at least three different polyorganosiloxanes, in which the mixture includes (A) a polyorganosiloxane having a vinyl group, (B) a polyorganosiloxane having two or more Si—H groups in a molecular chain, and (C) a branched polyorganosiloxane represented by the following General Formula (C), and the content of the polyorganosiloxanes (A), (B), and (C) is respectively 10 to 99.4 parts by mass, 0.5 to 90 parts by mass, and 0.1 to 40 parts by mass, with respect to 100 parts by mass of the total mass of the polyorganosiloxanes mixture. R1 to R4 each independently represent an alkyl group, a cycloalkyl group, an alkenyl group, or an aryl group. m represents an integer of 1 or more and n represents 0 or an integer of 1 to 5. At least two of a plurality of R4's are alkenyl groups. |
| US10076301B2 |
Devices, systems, and methods for assessment of vessels
Devices, systems, and methods for visually depicting a vessel and evaluating treatment options are disclosed. A method of evaluating a vessel of a patient, comprises: obtaining intravascular data from an intravascular instrument positioned within a vessel of a patient while the intravascular instrument is moved longitudinally through the vessel from a first position to a second position; obtaining an angiographic image of the vessel while the intravascular instrument is moved longitudinally through the vessel; correlating the intravascular data from the intravascular instrument to locations on the angiographic image; and outputting an enhanced angiographic image of the vessel on a display, the enhanced angiographic image including the angiographic image overlaid with visualizations representing the intravascular data at the correlated locations. Corresponding systems are also provided. |
| US10076298B2 |
Image processing system and image processing device
A medical image system includes: X-ray equipment having a Talbot interferometer or a Talbot-Lau interferometer and including: an X-ray source configured to emit X-rays; a plurality of gratings arranged in a emitting direction of the X-rays; and an X-ray detector irradiated by the X-ray source and having conversion elements for accumulating charge and generating electrical signal to read the electrical signals generated to acquire moire fringe image; a subject absorption image generation unit configured to generate a subject absorption image based on moire fringe images containing a subject; a subjectless absorption image generation unit configured to generate a subjectless absorption image based on subjectless more fringe images; and an image unevenness correction unit configured to correct image unevenness of the subject absorption image, the medical image system further including a subjectless absorption image correction unit, wherein the image unevenness correction unit corrects image unevenness of the subject absorption image. |
| US10076295B2 |
Mobile C-arm system
A mobile C-arm system contains a main unit having a relocation apparatus for moving the main unit in a horizontal movement direction and a C-arm which is movable at least in the orbital and angular movement direction, a data processing unit having a memory for storing programs which are executed during operation, and a control and display system, connected to the main unit with operating and display elements. A plurality of sensors are provided for capturing at least part of the immediate environment of the C-arm. A control system is present, which is configured to warn against an obstacle in the intended or actual movement direction on the basis of the environment captured by at least one sensor, in dependence on an intended or actual movement of the main unit and/or at least part of the main unit in a movement direction. |
| US10076293B2 |
Rapid frame-rate wireless imaging system
A method for defining the shape of a radiation beam that is directed toward a subject and to a free-standing imaging detector detects the position and orientation of the imaging detector relative to a radiation source, then adjusts an aperture that lies in the path of the radiation beam to shape the beam for incidence on a predetermined area of the detector according to the detected imaging detector position. The radiation source is energized to emit the shaped radiation beam and the image data about the subject is acquired from the imaging detector. |
| US10076290B2 |
X-ray imaging apparatus and control method for the same
An X-ray imaging apparatus and control method for the same relate to a mobile X-ray imaging apparatus that allows a user to recognize whether the X-ray imaging apparatus is in an appropriate imaging distance from an object. The X-ray imaging apparatus includes an X-ray source, an input unit that receives distance information between the X-ray source and an X-ray detector, a reference light emitter that irradiates a light from the X-ray source in a direction where the X-ray detector is placed, at least one auxiliary light emitter that irradiates a light that overlaps with a light from the reference light emitter; and a controller that determines an auxiliary light emitter corresponding to the distance information among the at least one auxiliary light emitter, and controls the reference light emitter and the determined auxiliary light emitter so that the reference light emitter and the determined auxiliary light emitter irradiate a light. |
| US10076289B2 |
Examination table of medical imaging system
This disclosure relates to an examination table of a medical imaging system comprising a tabletop, a table column supporting the tabletop, and a translation system. The translation system, which is configured to at least make the tabletop longitudinally translate with respect to the table column, comprises a guiding part and a driving part, where both the guiding and driving parts may be fully integrated in said table column. |
| US10076288B2 |
Medical treatment or examination device
A medical treatment or examination device includes at least one device component that may move relative to at least one other device component via a drive device. A measuring device is provided for detecting a load acting on the movable device component. The measuring device includes a support that bends due to the load. The support, at least in a bending region, has a section producing a magnetic field. The measuring device also includes at least one coil that is assigned to the section and in which the magnetic field undergoing a change as a result of bending due to a load induces an induction current that serves as measurement signal describing the load. |
| US10076286B1 |
Methods and devices for circadian rhythm monitoring
Methods for characterizing a circadian rhythm of a wearer of a wearable device are provided. In one example, physiometric measurements are obtained over a period of time by one or more sensors of a wearable device configured to be mounted to a body surface of a wearer. A circadian rhythm of the wearer, such as a sleeping, waking, eating or movement pattern, is characterized based on the physiometric measurements. Based on the identified circadian rhythm, one or more settings of the wearable device, such as a timing or frequency of obtaining physiometric measurements, may be adjusted. |
| US10076283B2 |
Method and device to manage fluid volumes in the body
A system and method for determining the amount of fluid to be removed from a dialysis patient is disclosed. The system utilizes sensors and a computer. The computer obtains the input parameters from the sensors, along with information added directly by the user, and performs a forward algorithm to determine a recommended change in patient fluid level. As fluid is removed, the effect of the removal on the parameters is detected by the sensors and re-transmitted back to the computer. The computer then performs a backward algorithm to refine the variables used in the forward algorithm and obtain more accurate results. The system and method provide for changing the amount of fluid removed from the patient based on the results of the algorithm and the data received from the sensors. |
| US10076278B2 |
Headband, headgear, and electroencephalographic apparatus
To provide a headband capable of correctly placing an electrode on a head of a user, a headband apparatus includes a plurality of headband portions integrally connected and configured to be positioned about a head of a user, wherein at least two headband portions are each configured to be positioned behind an ear. |
| US10076275B2 |
Information processing device, information processing system, and program
The present technology relates to an information processing device, an information processing system, and a program which enable a state of pores to be understood in further detail.A photographing unit photographs skin of a person irradiated with first light of a first wavelength band or second light of a second wavelength band different from the first wavelength band. A pore detecting unit detects pores in a first skin image, which is an image obtained by photographing the skin of the person irradiated with the first light. A porphyrin detecting unit detects a pore state of the skin of the person based on pixel values of a plurality of color components of each of pixels of a second skin image, which is an image obtained by photographing the skin of the person irradiated with second light. A display control unit distinguishes pores in which an abnormality is detected and normal pores based on a detection result of the pores and the pore state of the skin of the person and control display of the pore state of the skin of the person. The present technology can be applied to a system for analyzing a pore state of skin, for example. |
| US10076274B2 |
System and method for non-invasive detection of human cranial conditions
Vascular conditions are detected non-invasively in the human body using a collection of information from small local regions of the vasculature. An array of accelerometers are attached to the head and blood flow sounds are recorded. Vibration signatures of vessel structures such as branches, aneurysms, stenosis, etc. using random, periodic, band limited or transient analysis provides a signature library for further processing. The signature library is used to localize the origin of recognized vascular features and the localized feature is presented to the physician in a clinically relevant manner. |
| US10076273B2 |
Real-time monitoring and control of physical and arousal status of individual organisms
The present invention relates to methods and systems for monitoring and controlling the status of humans or animals, in particular relating to both the physical and the arousal status of an individual human or animal. These methods and systems rely on a dynamic and adaptive data-based on-line modelling technique wherein information on bioprocess inputs and outputs is measured in real-time and the model predicts an output based on the bioprocess input. The provided methods are particularly useful to monitor and/or control processes in which performance is important. |
| US10076272B2 |
Systems and methods for phlebotomy through a peripheral IV catheter
An apparatus includes a catheter, an introducer having a first member and a second member, a locking mechanism coupled to a distal end of the first member and configured to couple the introducer to a peripheral intravenous line, and an actuator coupled to the catheter. The actuator is configured to move from a first configuration, in which the catheter is disposed within the introducer, toward a second configuration to move the second member to a distal position relative to the first member. A portion of a guide of the second member being distal to the first member when the second member is in the distal position. The actuator is configured to move relative to the second member to be placed in the second configuration when the second member is in its distal position such that the catheter is disposed within and extending past an end of the peripheral intravenous line. |
| US10076270B2 |
Detecting physiological responses while accounting for touching the face
Described herein are systems and methods for detecting a physiological response based on thermal measurements while accounting for touching the face. In one embodiment, a system includes an inward-facing head-mounted thermal camera (CAM) that takes thermal measurements of a region of interest (THROI) on a user's face, and a sensor that provides measurements (M) indicative of times at which the user touches the region of interest (ROI). The system also includes a computer that detects the physiological response based on THROI and M. Optionally, the computer generates feature values based on THROI and M, and utilizes a model to detect, based on the feature values, the physiological response. Optionally, the model was trained based on samples, each including: (i) feature values generated based on previous THROI taken while M indicated touching the ROI, and (ii) a corresponding label indicative of an extent of the physiological response. |
| US10076266B2 |
Devices and methods for a neonate incubator, capsule and cart
Systems and method for positioning a neonate within an imaging device are provided. A capsule incubator, a cart, and a docking incubator are used to move a baby between an imaging device and a incubator, such that a baby can be imagined without having to move the baby from its environment. |
| US10076265B2 |
Magnetic resonance visible labels and markers for encoding information
Systems and methods for manufacturing and using magnetic resonance (“MR”) visible labels or markers to encode information unique to the subject or object being imaged by a magnetic resonance imaging (“MRI”) system are provided. The use of such MR-visible labels or markers enables unique information associated with the subject or object being imaged to be encoded into the images of the subject or object. This information can be used to anonymize protected health information (“PHI”); to provide detailed information about a surgical simulation device, quality assurance phantom, or the like; to provide spatial orientation and registration information; or so on. |
| US10076262B2 |
Localized physiologic status from luminosity around fingertip or toe
Systems and methods are directed to generating and analyzing light. Spatial light response around a human fingertip in response to electrical stimulation is associated with the status of various body organs. A system that provides a particularized response indication based on spatial light response includes a camera, an electrical signal generator, a light source, a circuit, and a computer. The signal generator stimulates emission of light from the finger when the finger is at a position relative to the camera. The light source illuminates the finger at the position. The circuit activates the light source and the camera to obtain a first image of the finger at the position, activates the signal generator and the camera to obtain a second image of the emission of light from the finger at the position, determines a direction from the first image, determines a centroid from the second image, and determines a description of the second image in accordance with the direction and the centroid. The computer receives indicia of the description and provides the particularized response indication in accordance with the description, wherein the particularized response indication describes a status of various body organs. |
| US10076257B2 |
Seamlessly embedded heart rate monitor
This is directed to an electronic device having an integrated sensor for detecting a user's cardiac activity and cardiac electrical signals. The electronic device can include a heart sensor having several leads for detecting a user's cardiac signals. The leads can be coupled to interior surfaces of the electronic device housing to hide the sensor from view, such that electrical signals generated by the user can be transmitted from the user's skin through the electronic device housing to the leads. In some embodiments, the leads can be coupled to pads placed on the exterior of the housing. The pads and housing can be finished to ensure that the pads are not visibly or haptically distinguishable on the device, thus improving the aesthetic qualities of the device. Using the detected signals, the electronic device can identify or authenticate the user and perform an operation based on the identity of the user. In some embodiments, the electronic device can determine the user's mood from the cardiac signals and provide data related to the user's mood. |
| US10076256B2 |
Method and system for evaluation of functional cardiac electrophysiology
An organ evaluation device, system, or method is configured to receive electrophysiological data from a patient or model organism and integrates the data in a computational backend environment with anatomical data input from an external source, spanning a plurality of file formats, where the input parameters are combined to visualize and output current density and/or current flow activity having ampere-based units displayed in the spatial context of heart or other organ anatomy. |
| US10076252B2 |
Sizable wrist-worn pressure sensing device
A wrist-worn pressure sensing device includes a pressure sensor. The wrist-worn pressure sensing device also includes a first strap that sets the position of the pressure sensor on a wearer's wrist and a second strap that engages with the first strap to adjust the overall length of the strap without moving the set position of the pressure sensor on the wearer's wrist. |
| US10076251B2 |
Physiology signal sensing device
A physiology signal sensing device includes an elastic pad and a strain sensor element. The elastic pad is used for contact with a human body, and corresponds a blood vessel of the human body. The strain sensor element is disposed in the elastic pad and includes a conductive element. The conductive element deforms according to the vibration of the blood vessel, and the resistance value of the conductive element varies according to the strain of the conductive element. |
| US10076247B2 |
System and method for evaluating tissue
A sensor system for measuring an elastic modulus and a shear modulus and a method for evaluating a tissue. The invention pertains to a method for determining the presence of and/or characterizing abnormal growths, using a piezoelectric finger sensor (PEFS) system. The PEFS system may be particularly useful for screening for tumors and various forms of cancer. Additionally, the PEFS system may be useful for various dermatological applications. |
| US10076246B2 |
Method and apparatus for noninvasive quantitative detection of fibrosis in normal and viable myocardium by MRI
Embodiments provide a noninvasive quantitative method for detecting extent and/or types of fibrosis in the heart. In embodiments, information pertaining to the extent and/or types of fibrosis may aid in the diagnosis of specific cardiac diseases and heart failure and/or may assist in determining suitable treatment options. Embodiments provide methods and apparatuses for determining the extent of fibrosis in viable and nonviable myocardium, which may then be correlated to heart disease and failure. Thus, in an embodiment, a method of screening individuals for the purpose of heart disease or heart failure prevention may be provided using the detection methodology described herein. |
| US10076243B2 |
Ophthalmic imaging device
An ophthalmic imaging device for capturing a tomographic image of an eye, includes: an OCT optical system detecting interference of reference light and measurement light; a measurement optical system including an optical scanner and an objective optical system, the optical scanner being configured to deflect the measurement light to perform scanning with the measurement light; a driver configured to displace a relative position of the optical scanner with respect to the objective optical system in an optical axis direction; and a controller configured to control the driver to adjust a turning position of the measurement light in the optical axis direction. The controller changes the turning position between a first position corresponding to a first depth band of the eye and a second position corresponding to a second depth band of the eye which is different from the first depth band. |
| US10076242B2 |
Systems and methods for automated classification of abnormalities in optical coherence tomography images of the eye
Systems and methods for classifying abnormalities within optical coherence tomography images of the eye are presented. One embodiment of the present invention is the classification of pigment epithelial detachments (PEDs) based on characteristics of their internal reflectivity, size and shape. The classification can be based on selected subsets of the data located within or surrounding the abnormalities. Training data can be used to generate the classification scheme and the classification can be weighted to highlight specific classes of particular clinical interest. |
| US10076240B2 |
Foldable ophthalmic system
There is a need for robust and portable system, and apparatus for ophthalmology. We propose use of foldable ophthalmic system. Our system will have a chin-rest (or face-rest or forehead rest) that can be folded so that the ocular device could be transported in a brief-case type casing. Our system can be used for many modalities including optical coherence tomography. |
| US10076237B2 |
Tissue resecting system
A surgical system includes a first instrument defining a first channel and a second instrument receivable by the first channel. The second instrument defines a second channel. A valve coupled to the first instrument controls fluid flow through the first channel, such that impedance of fluid flow through the first channel is substantially the same without the second instrument received in the first channel and with the first channel partially blocked by the second instrument. In another aspect, a surgical apparatus includes an outer member and an inner member received within the outer member to define a first channel therebetween. The inner member houses an optical lens and defines a second channel for receiving a surgical instrument. The first and second channels are configured such that a pump having an inflow rate of up to about 0.7 L/min connected to the second channel can maintain fluid pressure inside an organ. |
| US10076230B2 |
Endoscope system and operation method of endoscope system
An endoscope system includes: a CMOS image pickup device configured to output digital signals of a plurality of systems; E/O converters configured to convert the digital signals of the plurality of systems to optical signals respectively; optical fibers configured to transmit the optical signals of the plurality of systems respectively; a transmission amount changer configured to convert a data amount of the digital signal of at least one system; and a metal wire configured to transmit the digital signal, the data amount of which is converted by the transmission amount changer. |
| US10076228B1 |
Minimally invasive networked surgical system and method
A system for performing non-invasive networked medical procedures including a number of in vivo medical devices, a communication path between at least two of the devices, an ex vivo control unit to control the behavior of the devices, and a wireless communication path between the control unit and at least one of the devices. An associated method for performing non-invasive networked medical procedures is also provided. Further included is a simulation method that utilizes accurate electromagnetic field simulations, using a software based test bench, to determine the maximum allowable transmitted power levels from in vivo devices to achieve a required bit error rates (BER) at an in vivo or ex vivo node (receiver) while maintaining the specific absorption rate (SAR) under a required threshold. |
| US10076227B2 |
Dishwasher
A dishwasher, in particular a free-standing dishwasher or a high-level built-in dishwasher, includes an appliance door and a bottom-side plinth cover which is aligned essentially flush with a front face of the appliance door. The plinth cover has a top wall which faces a lower edge of the appliance door and is spaced from the lower edge of the appliance door to allow for an opening movement of the appliance door across a free movement gap. At least one lighting element is provided to allow illumination of the movement gap between the lower edge of the appliance door and the top wall of the plinth cover. |
| US10076222B2 |
Cleaning tool
Provided is a cleaning tool with which a cleaning sheet can be efficiently used during cleaning. A cleaning sheet is provided with holding spaces through which a cleaning-body holder is inserted. The cleaning-body holder is provided with: cleaning-body holding parts which are inserted into the holding spaces to hold the cleaning sheet; and a handle part which is connected to the cleaning-body holding parts, and which is to be held by a user. The cleaning-body holding parts are provided with: base parts connected to the handle part; tip parts at an opposite side to the base parts; and intermediate parts which extend from the base parts towards the tip parts. In a state in which the cleaning-body holding parts have been inserted into the holding spaces to hold the cleaning sheet, sections of the cleaning sheet corresponding to the intermediate parts are configured so as to be thicker, in the thickness direction of the cleaning sheet, than sections of the cleaning sheet corresponding to the base parts. |
| US10076220B2 |
Floor cleaning machines having intelligent systems, associated sub-assemblies incorporating intelligent systems, and associated methods of use
A floor cleaning machine having an intelligent system including a recovery tank sub-assembly, a vacuum fan sub-assembly, a solution tank sub-assembly, wherein the solution tank sub-assembly preferably includes a secondary electrochemical cell, a solution flow sub-assembly, a control console sub-assembly, a frame and wheel sub-assembly and/or a frame and transaxle sub-assembly, a scrub head sub-assembly, a scrub head lift sub-assembly, a squeegee sub-assembly, a solution flow sub-assembly, and an intelligent system associated with at least one of the above-identified sub-assemblies, wherein the intelligent system at least one of selectively gathers, obtains, monitors, stores, records, and analyzes data associated with components of the floor cleaning machine assembly, and at least one of controllably communicates and disseminates such data with at least one of another system and user. |
| US10076216B2 |
Foaming soap dispensers
Various dispensing devices, such as foaming soap pumps, are disclosed. The soap pump can include a fluid storage unit and a fluid handling unit. The fluid storage unit can include a reservoir that is configured to hold a quantity of product, such as liquid soap. The fluid handling unit can include a pumping assembly and dispensing assembly. The soap pump can be configured to withdraw liquid soap from the reservoir, convert the liquid soap to foamed soap, and dispense the foamed soap from the discharge assembly. |
| US10076215B1 |
Portable bidet seat
Portable, self-contained bidet seat (10) to be placed on toilet or other waste disposal means. Bidet seat (10) holds washing liquid (100) in hollow central chamber (23). Pressure means (40) is activated by user to pressurize washing liquid (100) and air (101) in chamber (23). Pressurized liquid (100) is sprayed or jetted onto user to replace use of toilet paper. Bidet seat (10) is adapted for use by persons with limited strength or agility. |
| US10076213B1 |
Kitchen implements for separating lipids from food
A kitchen utensil for removing lipids from food includes a handle having a first end, a second end, and a gripping region between the first end and the second end, a head extending from the second end of the handle, the head having first side, a second side, and an outer perimeter, and wherein the first side includes at least one groove extending inwardly from a first groove end located at the outer perimeter, the at least one groove configured to collect a lipid material therein. |
| US10076211B1 |
Sausage cookware
Sausage cookware includes a hollow pan having a cooking surface with multiple undulations that partially conform to the outer circumference of a link sausage. Other embodiments include an insert for converting the flat cooking surface of a conventional frying pan or electric cooker to an undulated surface that more efficiently cooks link sausages. |
| US10076192B2 |
Air-circulating mat
An air-circulating mat for a seating device is disclosed. At a lower end part of a bag-shaped body, an opening portion for mounting an air blower is formed. A spacer ensures an air path through which the air flows inside the bag-shaped body and is contained in the bag-shaped body. This spacer is made of plastic and includes a plurality of convex parts and a plurality of flexible connection portions with flexibility for connecting the adjacent convex parts. At an upper end part on the right side of the bag-shaped body is an air circulating portion for discharging the air flowing through the air path to the outside. A battery containing portion for containing a battery that supplies electric power to the air blower is provided so as to continue to a predetermined end portion of the spacer located on a back portion side of a user in use. |
| US10076191B2 |
Chair back structure
A chair back structure is disclosed and includes a chair back that includes a frame, an upper support pad coupled to an upper portion of the frame, and a lower support pad arranged at a lower end of the upper support pad, and an elastic connection piece connecting the upper support pad and the lower support pad to each other. The upper support pad includes a lower support pad coupling seat. The lower support pad includes an upper support pad coupling seat. The elastic connection piece has an upper end mounted to the lower support pad coupling seat of the upper support pad and a lower end mounted to the upper support pad coupling seat of the lower support pad, so that the lower support pad is provided with elasticity and movability by means of the elastic connection piece. |
| US10076187B2 |
Drawer assembly with bezel including an integral drawer centering device
A drawer assembly is provided. That drawer assembly includes a drawer and a bezel. The bezel includes an integral drawer centering device whereby smooth sliding action of the drawer in the bezel is provided. The bezel and the integral drawer centering device are molded as a unitary component. |
| US10076183B2 |
Surface cleaning head
A surface cleaning head is disclosed. The surface cleaning head includes a housing, a brush system, and a panel open detector. The brush system includes a brush and a brush drive member drivingly connected to the brush. The brush is moveably mounted in the brush chamber and removably from the brush chamber. A panel open detector is operatively connected to a brush interruption member and the brush interruption member is operatively connected to the brush system. When the panel open detector detects that a panel on the housing is opened, the brush interruption member interacts with the brush system to prevent the brush drive member driving the brush. |
| US10076180B2 |
Oral care implement
An oral care implement having a grip component. In one embodiment, the invention can be an oral care implement comprising: an elongated body comprising a head portion and a handle portion, the handle portion comprising a socket; at least one tooth cleaning element mounted to the head portion of the elongated body; and a first grip component comprising: an annular rim defining a central opening, the annular rim formed of a rigid material; and a resilient body mounted to the annular rim that covers the central opening, the resilient body formed of a resilient material; the first grip component mounted within the socket. |
| US10076174B2 |
Substantively hermetically sealing container
A container that seals in a volume of material is provided. The container may be routinely opened, closed and material may be removed or added. A removable plate and a base define a maximum volume available for material when the container is sealed. A screen may be disposed between the plate and the base. The screen may optionally be comprised within the base, adhered to the base, or removable from the base. Features for enabling manipulation of the plate and/or screen are optionally provided. |
| US10076172B2 |
Diffuser
A diffuser includes a baffle having an air inlet end, an air outlet end and an outwardly tapering wall extending between the air inlet end and the air outlet end, and which defines a diffusing air chamber, and a grille connected to the baffle, the grille including a plurality of air outlets. The air inlet end of the baffle includes an air inlet and a drainage channel, spaced from the air inlet, for receiving water which has entered the air chamber through the air outlets. The drainage channel has drainage holes for draining water away from the air inlet. |
| US10076170B2 |
Children's zipper pull
A storage solution for children's toys is described. A storage and transportation device for children's items (e.g., toys, puzzles, craft supplies, etc.) is specially designed to be used by children, including children under three years old. The storage solution may also include an improved zipper pull for opening and closing the storage and transportation device. |
| US10076159B2 |
Soil-shedding article of footwear, and method of using the same
Disclosed herein are articles of footwear, and methods of manufacturing articles of footwear, having an open-cell foam present on at least a portion of the outsole. The open-cell foam is effective in reducing soil accumulation on the outsole when the footwear is worn on unpaved surfaces. |
| US10076153B2 |
Thermal protection system and related compositions of matter
A thermal protection system is disclosed herein. In various aspects, the thermal protection system includes an insert. The insert may include a first layer and a second layer bonded to one another. The insert may be removeably receivable within a cavity of a shoe to form a thermally insulating barrier between a plantar surface of a user's foot and a sole of the shoe with a side of the first layer oriented toward the sole and a side of the second layer oriented toward the plantar surface. The first layer may include an aerogel and the second layer may include a meta aramid polymer, in various aspects. Related compositions of matter disclosed herein, in various aspects, include a plurality of layers bonded to one another in the form of an insert removeably receivable within a cavity of a shoe to create a thermal barrier between a sole of the shoe and a plantar surface of a foot of a user. This Abstract is presented to meet requirements of 37 C.F.R. § 1.72(b) only, and is not intended to identify key elements of the apparatus, methods, and compositions of matter disclosed herein or to delineate the scope thereof. |
| US10076152B2 |
Article of footwear for athletic and recreational activities with bootie
An article of footwear with an inner bootie that fits into and is strapped into an external shell to form the article of footwear. The inner bootie may have specially-treated regions that together allow the bootie to slip readily into the external shell and to be held firmly in place. When the inner bootie is in place in the external shell, cable loops woven into the lateral side and the medial side of the inner bootie protrude from corresponding openings in the external shell. A lace may then be laced through the cable loops to fasten the throat opening of the external shell over a wearer's foot. |
| US10076148B2 |
Bespoke cap having two distinct fabric patterns
The present invention generally relates to a bespoke cap for covering and gathering dreadlocks. More specifically, two distinct fabric patterns are layered to form a cap. The first layer's fabric pattern is a crown having a front facing brim and a half oval cut into its rear surface. The crown provides a deep volume to accommodate a large amount of dreadlocks. The second layer is a five piece fabric pattern that is sewn onto and over the first layer. Both layers combine to provide an adjustable oval like aperture at the back of the cap, which allow dreadlocks to be covered and gathered naturally without being damaged. Top panels associated with the second layer have rear closing straps that cinch the aperture at an angle. Each top panel stretches and folds over the first layer's front facing brim to its underside, providing a stylish flat-cap appearance. |
| US10076144B2 |
Elongated wrist towel with elastic rim and seam
An elongated wrist towel for wearing on a user's wrist without exerting circumferential pressure over a large portion of the user's arm includes a towel body defining a hollow, elongated sleeve and is sized to encircle the distal arm of a user. The towel body includes an elastic distal edge which allows the elongated wrist towel to be secured to a user's wrist, a non-elastic proximal edge, and an elastic seam which runs longitudinally between the proximal edge and the distal edge. In this regard, when in place on a wearer's arm, the elongated wrist towel can be retained on the wrist through compression from a single rim and selectively moved between extended and compacted positions on a user's arm. |
| US10076142B2 |
Durable reflective safety apparel with active laser illumination
Some embodiments provide reflective safety apparel that combines passive illuminating elements with active illuminating elements for improved nighttime visibility. The active illuminating elements include a laser module coupled to flexible laser tubing. The laser module directs laser light into the flexible laser tubing. The laser tubing retains and transfers the laser light throughout its length even when bent. This flexibility allows the active illuminating elements to outline and conform to the shape of the passive illuminating elements. The laser tubing from different garments, such as a jacket and pants, can be coupled together. A single laser module can illuminate both garments as the laser light traverses the laser tubing of one garment to the other. |
| US10076141B2 |
Halter bib athletic garment
A halter bib athletic garment is described herein. A halter bib athletic garment may be removed or lowered without removing a jersey by simply pulling a halter strap over the head of a wearer. One or more embodiments of a halter bib allow wearers to more readily urinate or have a bowel movement because the halter bib may be easily lowered or removed. A halter bib athletic garment may include a lower body section, a chamois coupled to the lower body section, and an upper body section. The upper body section comprises a halter strap forming a portion of a loop of a head opening on the upper body section. The halter strap includes two front side portions and a rear side portion positioned between the front side portions. The rear side portion is coupled to the athletic garment only with the front side portions of the halter strap. |
| US10076140B2 |
Aerosol-generating system for delivering nicotine salt particles
An aerosol-generating system is provided, including a nicotine source, a lactic acid source, and a single heater configured to heat both the nicotine source and the lactic acid source. The aerosol-generating system may also include an aerosol-generating article including a cartridge having a first compartment including the nicotine source and a second compartment including the lactic acid source; and an aerosol-generating device including the single heater. The cartridge may also include a cavity configured to receive the single heater of the aerosol-generating device. |
| US10076139B2 |
Vaporizer apparatus
Vaporizer devices and apparatuses are provided. In some implementations, an apparatus comprises a cartridge and a vaporizer body. The cartridge comprises a storage compartment configured to hold a vaporizable material, a heater comprising a resistive heating element for generating an aerosol, and a mouthpiece comprising an opening for passage of the aerosol. The vaporizable material is visible through at least one side of the storage compartment. The vaporizer body comprises a proximal end, a distal end opposite the proximal end, and a cartridge receptacle at the proximal end, the cartridge receptacle configured to house the cartridge. The cartridge receptacle comprises a notch extending from the proximal end towards the distal end, and a portion of the storage compartment is visible through the notch when the cartridge is housed in the cartridge receptacle. |
| US10076137B2 |
Vaporizer and vaporizer cartridges
Disclosed herein are methods and systems to vaporize extract, plant material containing organic material and the like, including utilizing a cartridge which may be disposable. The cartridge may be heated in zones or portions. The cartridge may form the inhalation pathway thereby reducing the accumulation of dirt and odor in the heating device. One disclosed vaporizer system has a base with a cartridge interface, a heater element, an on/off switch, a battery, a temperature sensor in proximity to the heater element; a controller in signal communication with the heater element, battery, temperature sensor and the on/off switch; that mates with a disposable cartridge. |
| US10076136B2 |
Smoking article wrapper with window
A wrapper (510) for a smoking article comprises a sheet material extending in a first direction (24) in which the wrapper (510) is wrapped around a smoking article and a second direction (20) perpendicular to the first direction (24). The wrapper further comprises a window (512) in the sheet material, the window (512) having a perimeter wherein the perimeter comprises a first portion (518) that defines a projection (516) of the sheet material into the window (512). The projection (516) is delimited by the first portion (518) of the perimeter and a straight line (520) forming a tangent to each end (522, 524) of the first portion (518) of the perimeter, and the distance between the straight line (520) and the point on the first portion (518) of the perimeter furthest from the straight line (520) in a direction perpendicular to the straight line (520) is less than 1 millimeter. |
| US10076135B2 |
Biodegradable cigarette filter tow and method of manufacture
A biodegradable cigarette filter tow includes a mixture of at least two or more natural materials selected from the group consisting of hemp fiber, flax fiber, abaca fiber or pulp, sisal fiber or pulp, wood pulp, and cotton fiber or cotton flock. The mixture may also include regenerated cellulose fibers. The mixture may include a natural binder or may be hydroentangled. |
| US10076133B2 |
Freeze-dried aerated fruit and/or vegetable compositions and methods of making thereof
A freeze-dried, aerated fruit and/or vegetable composition that includes fruit and/or vegetable ingredient(s) and an emulsifier are disclosed, as well as methods of making thereof. |
| US10076129B1 |
Systems and methods for inhibiting spoilage of stored crops
Systems and methods for treating large quantities of potatoes, other tubers, vegetables, produce, and/or other crops are disclosed herein. In one embodiment, a crop storage facility configured in accordance with the present technology includes a treatment system configured to distribute a treatment agent configured to inhibit spoilage of the crops. The treatment system can include a combination of two or more chemical compositions configured to release different concentrations of the treatment agent to produce a desired level of the treatment agent in the storage facility. |
| US10076128B2 |
Composition comprising cinnamon extract
The invention concerns a composition for lowering the glycemic index comprising, or consisting of an alcoholic extract of cinnamon in an amount of at least 10% by weight compared to the total weight of the composition, and optionally a carrier, a food composition comprising a composition for lowering the glycemic index in an amount ranging from 0.1% to 5% by weight compared to the total weight of the food composition, the use of a composition for lowering the glycemic index or of a food composition as a glycemic index lowering agent. |
| US10076127B2 |
Process for modifying protein digestion of ruminant feeds and products produced therefrom
Processes for increasing rumen undegraded protein in protein containing compositions, fermentation by-products or combinations thereof are disclosed. Uses of alkaline crystalline solids to increase rumen undegraded protein in protein containing compositions, fermentation by-products or combinations thereof are further disclosed. Products produced from such processes are also disclosed. |
| US10076125B2 |
Polypeptide for hydrolytic cleavage of zearalenone and/or zearalenone derivatives, isolated polynucleotide thereof as well as a polypeptide containing an additive, use of same as well as a process
The invention relates to a polypeptide for the hydrolytic cleavage of zearalenone and/or at least one zearalenone derivative, said polypeptide being a hydrolase having an amino acid sequence selected from the group consisting of SEQ ID NO: 1-15 or a functional variant thereof, wherein the sequence of the functional variant is at least 40% identical to at least one of the amino acid sequences. The invention also relates to: an additive containing the polypeptide; an isolated polynucleotide that encodes the polypeptide; and a method for the hydrolytic cleavage of zearalenone and/or of at least one zearalenone derivative using the polypeptide. |
| US10076123B1 |
Method for reduction in microbial activity in red meat
A process for reducing the bacterial count on a red meat carcass during the processing of livestock, such as bovine or swine, by applying an intervention solution having at least one equilibrium peroxycarboxylic acid or a pH modified peroxycarboxylic acid comprising peroxyacetic acid to the red meat carcass at an elevated temperature above 100° F. and at a concentration of at least 10 ppm, preferably an elevated concentration of at least 200 ppm, for a desired period of time of less than about 60 seconds, preferably less than about 30 seconds, to reduce the bacterial count by at least 60 percent. |
| US10076122B1 |
Sausage cutting apparatus
A sausage cutting apparatus 10 for cutting an extruded length of sausage into smaller sausage portions includes first and second cutting assemblies located at opposite sides of a feed path. The cutting assemblies include flexible toothed belts 38 driven by toothed pinions, to which a number of longitudinally-spaced cutting device 30 are fixedly attached. The apparatus includes a drive system for synchronously driving the belts 38 and a guide system for guiding displacement of the cutting devices into and out of meshing engagement with one another for cutting the length of sausage. Each cutting device includes a cutting blade defining a domed cutting face at an inner side thereof. The cutting devices are displaced along arcuate cutter paths during meshing engagement of the cutting blades wherein the cutting faces of opposing pairs of cutting blades mesh with a slight interference fit in a conjugate meshing action. |
| US10076119B2 |
Pesticidal mixtures
The present invention relates to pesticidal mixtures comprising one biological compound and at least one fungicidal, insecticidal or plant growth regulating compound as defined herein and respective agricultural uses thereof. |
| US10076117B2 |
Pesticide formulation comprising a water soluble active ingredient and a penetration enhancer and use of the same
The present disclosure relates to an improved formulation comprising at least one water soluble active ingredient and at least one penetration enhancer. The present disclosure also relates to a use of an improved formulation comprising at least one water soluble active ingredient and at least one penetration enhancer for preventing, combating or controlling pests, particularly insect infestations, by tree injection. |
| US10076111B2 |
Game alert system
A game alert system includes a device mountable on a game feeder that detects motion in a target area and automatically sends an electronic signal to a user, or a hunter, in a remote location to notify the hunter of movement in the area, without alerting or startling animals that triggered the device. The system may include one or more cameras (which may be 360 degree cameras) and/or one or more GPS systems for obtaining photographs and/or video and/or collecting geographic data. The system may further include multiple motion sensors and a hub which wirelessly communicate with one another and which may communicate wirelessly with a user device such as a smartphone, tablet, night vision equipment, or other device. |
| US10076109B2 |
Systems and methods for trapping animals
A system for trapping animals includes a cable and an enclosure adapted to be suspended above a trap area by the cable. A release mechanism includes a pivotable member, and the pivotable member is configured to rotate about a pivot support between an engaged position and a released position. The pivotable member in the engaged position supports the cable to hold the enclosure in a suspended position, and the pivotable member in the released position releases the cable to allow the enclosure to fall from the suspended position and enclose the trap area. The system further includes an actuator, which in an extended position holds the pivotable member in the engaged position. In a retracted position, the actuator releases the pivotable member to allow the pivotable member to rotate into the released position. |
| US10076107B2 |
Belt engageable fishing pole holder
A belt engageable fishing rod holder is provided having a body, a front wall, and a rear wall extending between two ends and a pair of opposing side edges. A belt running through the body is adapted for passage of a belt therethrough to hold the body against the body of a user where a rod holder projecting a front wall is configured to engage a handle end of a fishing rod. |
| US10076104B2 |
Alimentary composition comprised of insects and tetrahydrocannabinol
Variable-scale, modular, easily manufacturable, energy efficient, reliable, and computer operated Insect Production Superstructure Systems (IPSS) may be used to produce insects for human and animal consumption, and for the extraction and use of lipids for applications involving medicine, nanotechnology, consumer products, and chemical production with minimal water, feedstock, and environmental impact. An IPSS may comprise modules including feedstock mixing, enhanced feedstock splitting, insect feeding, insect breeding, insect collection, insect grinding, pathogen removal, multifunctional flour mixing, and lipid extraction. An IPSS may be configured to be constructed out of a plurality of containerized modules. |
| US10076103B2 |
Transgenic transchromosomal rodents for making human antibodies
The present invention provides novel transgenic nonhuman mammals capable of producing human sequence antibodies, as well as methods of producing and using these antibodies. |
| US10076102B2 |
Bovine rumination and estrus prediction system (BRES) and method
A bovine monitoring system may include a rumination sensor, a motion sensor, a posture sensor. The rumination sensor may detect chewing by sensing jaw motion. The motion sensor may detect motion. The posture sensor may detect orientation of the bovine asset through detection of gravitational acceleration, detection of gyroscopic rotation, or a combination of gravitational acceleration and gyroscopic rotation. Using the recorded rumination, motion, and posture sensors, the bovine asset monitoring system may identify aberrations in the estrous cycle or physical or mental health of the bovine assets. A bovine monitoring system may include a thermal scanning device to detect localized heating of the vulva area of the bovine asset, which may be used to identify aberrations in the estrous cycle or physical or mental health of the bovine assets. |
| US10076101B2 |
Pet leash structure
A pet leash structure comprises a main leash body and a drag leash. The main leash body is weaved by a strap body and has a handle portion provided for a person to hold and a connection portion connected to a collar. A pull section is formed between the handle portion and the connection portion. The drag leash has a predetermined length and is connected to a tail end of the pull section. Therefore, a distance between the person and a pet may be fixed by pulling the drag leash so that the person may quickly drag the pet back by pulling the drag leash. |
| US10076098B2 |
Animal litter box
An animal litter box has a transverse direction, a longitudinal direction and a vertical direction and includes a lower container having an opening at an upper end thereof and allocated on the lower side, an upper side cover allocated above the lower container and a liquid passable litter tray interposed between the upper side cover and the lower container and cooperating with the lower container to close the opening. The lower container has an excrement tray provided so as to be manually movable in the longitudinal direction between a put-in position at which the excrement tray is set within the receiving space below the liquid passable litter tray and a drawn out position outside the receiving space and an end opening through which the excrement tray is put into or drawn out from the receiving space. |
| US10076095B1 |
Lettuce cultivar Portola
A lettuce cultivar, designated Portola, is disclosed. The invention relates to the seeds, plants and plant parts of lettuce cultivar Portola and to methods for producing a lettuce plant by crossing the cultivar Portola with itself or another lettuce cultivar. The invention further relates to methods for producing a lettuce plant containing in its genetic material one or more transgenes and to the transgenic lettuce plants and plant parts produced by those methods. This invention also relates to lettuce cultivars or breeding cultivars and plant parts derived from lettuce cultivar Portola, to methods for producing other lettuce cultivars, lines or plant parts derived from lettuce cultivar Portola and to the lettuce plants, varieties, and their parts derived from the use of those methods. The invention further relates to hybrid lettuce seeds, plants, and plant parts produced by crossing cultivar Portola with another lettuce cultivar. |
| US10076094B2 |
Canola variety PV 560 GM
Provided is a canola variety designated PV 560 GM and seed, plants and plant parts thereof produced from a cross of inbred varieties. Methods for producing a canola variety comprise crossing canola variety PV 560 GM with another canola plant. Methods for producing a canola plant containing in its genetic material one or more traits introgressed into PV 560 GM through backcross conversion and/or transformation, and to the canola seed, plant and plant part produced thereby are described. Canola variety PV 560 GM, the seed, the plant produced from the seed, plant parts and variants, mutants, and minor modifications of canola variety PV 560 GM are disclosed. |
| US10076091B2 |
Pollen compositions and methods for distribution on flowering plants
The present invention encompasses a composition comprising a viable pollen suspension in a water miscible carrier. The compositions are especially suitable for mechanical distribution, such as, electrostatic spraying of the viable pollen composition onto a flowering plant to increase pollination. The invention further provides a mechanical system and method for applying droplets containing a viable pollen suspension to flowering plants to increase pollination. |
| US10076085B2 |
Stackable pots for plants
A pot for a plant may include a container having an axis that is vertical, a base, a sidewall extending upward from the base, an interior, an exterior, drain holes extending from the interior to the exterior and an interior bottom. The container may be configured to receive and be stacked with a second container inside of the container. In one example, the legs of the second container may be configured to extend through the drain holes of the container beyond the interior bottom of the container. In another example, the legs of the second container may be visible from the exterior of the first container. |
| US10076080B2 |
Unloading ramp for a round baler
An unloading ramp for a round baler includes an elongated, flexible carrier that has one end that can be attached or is attached to the round baler and on whose top side there is a rolling surface for a bale ejected from the round baler. |
| US10076075B1 |
Liquid dispensing system
A liquid dispensing system that includes a carrier having a storage tank disposed thereon for storing a liquid product. A boom is coupled to the carrier and includes a distribution hose through which the liquid product flows from the storage tank and into a number of liquid placement apparatuses. Each liquid placement apparatus includes a drop assembly coupled to the boom and extending downward. A base assembly is coupled to the lower end of the drop assembly and a hose assembly extends from the distribution hose to the base assembly. A lower hose assembly is protected within the base assembly and includes a pair of dribble hoses extruding from the base assembly. The liquid product is delivered proximate to the ground surface through the dribble hoses. |
| US10076074B2 |
Reversible seeder transmission and seeder drive apparatus
An apparatus for transmitting power from a drive shaft (24) to a seed meter shaft of a seed metering device includes a transmission (26). A transmission housing (28) has a first housing section (30) and an identical second housing section (30). The first housing section (30) and the second housing section (30) together define a first internal passageway (44) and a second internal passageway (50). The transmission further includes a first transmission element (46) rotatably supported by the first housing section (30) and the second housing section (30) in the first internal passageway (44). The first transmission element (46) connects to one of the drive shaft (24) and the seed meter shaft. The transmission further includes a second transmission element (54) rotatably supported by the first housing section (30) and the second housing section (30) in the second internal passageway (50). The second transmission element (54) engages the first transmission element (46) and connects to the other of the drive shaft (24) and the seed meter shaft. |
| US10076071B2 |
Machine for harvesting fodder
A machine for the harvesting of plants comprises an arm movable between work and transport configuration, a tool comprising lateral ends and being able to occupy a work position and another position, a connecting device via which the tool is connected to the arm and enabling a first movement of the tool relative to the arm, during which the lateral ends move vertically relative to the arm in the same vertical direction relative thereto, the connecting device can operate a second transverse and horizontal movement of the tool relative to the arm and making it possible to operate this second movement independently of the first movement. The connecting device comprises an arm articulated on the support arm about a first transverse and horizontal axis when the support arm is in the work configuration, and this arm can, by pivoting about the first axis, moved vertically relative to the support arm. |