Document Document Title
US08962967B2 Musical instrument with networking capability
Disclosed is a musical instrument with networking capability and application-driven features for expanding mobility and sharing of creations made using the instrument. In one embodiment, a musical instrument with networking capability, can include: a musical keyboard having a plurality of first keys and a plurality of second keys in a pattern that is repeatable at an octave, where the first keys are shorter and raised relative to the second keys; a touchscreen attached to the musical keyboard, where the touchscreen is movable between a flattened position and a collapsed position that is over the musical keyboard; a device connection interface configured to support a plurality of external connections; and a controller coupled to the musical keyboard, the touchscreen, and the device connection interface.
US08962963B1 Shape adjustable tambourine
A tambourine is provided with a crescent shell including two tubular segment elements at both ends respectively, through holes, and two sets of two spaced grooves each extending from either end of one tubular segment element; two curved mounting members each including two groups of two spaced tubular segment members at both ends respectively, each tubular segment member including two sets of projections on an outer surface; a curved handgrip including two tubular segment unit at both ends respectively, and two collections of two spaced depressions each extending from either end of one tubular segment unit; and jingle discs each pivotably disposed in the through hole. The mounting members are pivotably secured to both ends of the shell and the handgrip is pivotably secured to both ends of the mounting members.
US08962962B2 System and apparatus for adjusting the tonal output of a membranophone
The present invention is a system for modifying the tonal output of a hand drum. The system includes the use of a tonal cover or membrane to change the sound emitted when the head of a hand drum is struck. Additional tuning pads are then added to further modify the sound of the drum. Tonal adjustment is affected by the number, thickness, material and tautness of the additional pads and tonal cover. A partial coverage of the drum head by a tonal cover may also be utilized.
US08962958B2 Capo for stringed musical instruments
A tuning apparatus for a musical instrument is provided. The instrument includes a neck having a front surface over which a plurality of strings is stretched. The apparatus includes a clamp and a plurality of string-contacting members. The clamp is adapted to removably attach to a desired longitudinal position on the neck. Each of the members is rotatably supported by the clamp and is adapted to rotate on the clamp independently of the other members, this rotation occurring along a plane which is substantially parallel to either a given string or course of strings. Each of the members is further adapted to adjustably impinge upon and urge the given string or course of strings toward a user-selectable one of three different longitudinal positions on the front surface, these positions including a home position, a home−1 position, and a home+1 position.
US08962955B2 Music box
A music box includes a plurality of star wheels, a plurality of sun wheels, a drive unit, a plurality of anchoring members, a plurality of vibration valves, a rotating disk, a detection unit, and a control unit. Each of the plurality of anchoring members is configured to engage one of a plurality of protruding parts of the plurality of star wheels. The rotating disk is configured to rotate according to a rotation of an axis. The rotating disk is formed with a plurality of slits arrayed in a circumferential direction of the rotating disk. The detection unit is configured to detect a passage of one or more of the plurality of slits. The control unit is configured to control one or more of the plurality of anchoring members to disengage one of the plurality of protruding parts, based on a detection result of the detection unit.
US08962952B1 Inbred maize variety PHVZN
A novel maize variety designated PHVZN and seed, plants and plant parts thereof. Methods for producing a maize plant that comprise crossing maize variety PHVZN with another maize plant. Methods for producing a maize plant containing in its genetic material one or more traits introgressed into PHVZN through backcross conversion and/or transformation, and to the maize seed, plant and plant part produced thereby. Hybrid maize seed, plant or plant part produced by crossing the variety PHVZN or a locus conversion of PHVZN with another maize variety.
US08962950B2 Plants and seeds of hybrid corn variety CH796501
According to the invention, there is provided seed and plants of the hybrid corn variety designated CH796501. The invention thus relates to the plants, seeds and tissue cultures of the variety CH796501, and to methods for producing a corn plant produced by crossing a corn plant of variety CH796501 with itself or with another corn plant, such as a plant of another variety. The invention further relates to genetic complements of plants of variety CH796501.
US08962944B2 Pepper hybrid PS 16376104
The invention provides seed and plants of pepper hybrid PS 16376104 and the parent lines thereof. The invention thus relates to the plants, seeds and tissue cultures of pepper hybrid PS 16376104 and the parent lines thereof, and to methods for producing a pepper plant produced by crossing such plants with themselves or with another pepper plant, such as a plant of another genotype. The invention further relates to seeds and plants produced by such crossing. The invention further relates to parts of such plants, including the fruit and gametes of such plants.
US08962938B2 Soybean variety XB05A13
A novel soybean variety, designated XB05A13 is provided. Also provided are the seeds of soybean variety XB05A13, cells from soybean variety XB05A13, plants of soybean XB05A13, and plant parts of soybean variety XB05A13. Methods provided include producing a soybean plant by crossing soybean variety XB05A13 with another soybean plant, methods for introgressing a transgenic trait, a mutant trait, and/or a native trait into soybean variety XB05A13, methods for producing other soybean varieties or plant parts derived from soybean variety XB05A13, and methods of characterizing soybean variety XB05A13. Soybean seed, cells, plants, germplasm, breeding lines, varieties, and plant parts produced by these methods and/or derived from soybean variety XB05A13 are further provided.
US08962936B2 Soybean cultivar S110245
A soybean cultivar designated S110245 is disclosed. The invention relates to the seeds of soybean cultivar S110245, to the plants of soybean cultivar S110245, to the plant parts of soybean cultivar S110245, and to methods for producing progeny of soybean cultivar S110245. The invention also relates to methods for producing a soybean plant containing in its genetic material one or more transgenes and to the transgenic soybean plants and plant parts produced by those methods. The invention also relates to soybean cultivars or breeding cultivars, and plant parts derived from soybean cultivar S110245. The invention also relates to methods for producing other soybean cultivars, lines, or plant parts derived from soybean cultivar S110245, and to the soybean plants, varieties, and their parts derived from use of those methods. The invention further relates to hybrid soybean seeds, plants, and plant parts produced by crossing cultivar S110245 with another soybean cultivar.
US08962933B2 Soybean variety A1037459
The invention relates to the soybean variety designated A1037459. Provided by the invention are the seeds, plants and derivatives of the soybean variety A1037459. Also provided by the invention are tissue cultures of the soybean variety A1037459 and the plants regenerated therefrom. Still further provided by the invention are methods for producing soybean plants by crossing the soybean variety A1037459 with itself or another soybean variety and plants produced by such methods.
US08962931B2 CVYV-resistant plants of the species Cucumis melo
The present invention relates to Cucumis melo plants that are resistant against Cucumber Vein Yellowing Virus (CVYV), and to plant parts derived thereof without the occurrence of necrotic symptoms. The invention further relates to methods of producing said plants, to CVYV-resistant plants obtainable by said methods, as well as to plant parts derived from said CVYV-resistant plants. Specifically, the present invention relates to a plant of the species Cucumis melo, comprising in its genome a genetic element, said genetic element comprising a Cucumber Vein Yellowing Virus (CVYV)-resistance conferring Quantitative Trait Locus (QTL), or a CVYV-resistance conferring part thereof, genetically linked to at least one molecular marker, wherein said marker is selected from a group consisting of E13/M48-259.69-P2, E16/M48-377.36-P2, E13/M48-261.30-P2 and E26/M62-076.8-P2.
US08962929B2 Lettuce line PS 06518893
The invention provides seed and plants of the lettuce line designated PS 06518893. The invention thus relates to the plants, seeds and tissue cultures of lettuce line PS 06518893, and to methods for producing a lettuce plant produced by crossing a plant of lettuce line PS 06518893 with itself or with another lettuce plant, such as a plant of another line. The invention further relates to seeds and plants produced by such crossing. The invention further relates to parts of a plant of lettuce line PS 06518893, including the gametes of such plants.
US08962926B2 Pea line EX 08570957
The invention provides seed and plants of the pea line designated EX 08570957. The invention thus relates to the plants, seeds and tissue cultures of pea line EX 08570957, and to methods for producing a pea plant produced by crossing a plant of pea line EX 08570957 with itself or with another pea plant, such as a plant of another line. The invention further relates to seeds and plants produced by such crossing. The invention further relates to parts of a plant of pea line EX 08570957, including the seed, pod, and gametes of such plants.
US08962922B2 Spinach hybrid SV3580VC
The invention provides seed and plants of spinach hybrid SV3580VC and the parent lines thereof. The invention thus relates to the plants, seeds and tissue cultures of spinach hybrid SV3580VC and the parent lines thereof, and to methods for producing a spinach plant produced by crossing such plants with themselves or with another spinach plant, such as a plant of another genotype. The invention further relates to seeds and plants produced by such crossing. The invention further relates to parts of such plants, including the leaf and gametes of such plants.
US08962917B2 Delta-5 desaturase and its use in making polyunsaturated fatty acids
Isolated nucleic acid fragments and recombinant constructs comprising such fragments encoding delta-5 desaturase along with a method of making long chain polyunsaturated fatty acids (PUFAs) using this delta-5 desaturase in plants and oleaginous yeast are disclosed.
US08962916B2 Viral promoter, truncations thereof, and methods of use
The present disclosure provides compositions and methods for regulating expression of heterologous nucleotide sequences in a plant. Compositions include a novel nucleotide sequence for a promoter. A method for expressing a heterologous nucleotide sequence in a plant using the promoter sequence disclosed herein is provided. The method comprises stably incorporating into the genome of a plant cell a nucleotide sequence operably linked to the promoter of the present invention and regenerating a stably transformed plant that expresses the nucleotide sequence.
US08962915B2 Isolated polypeptides, polynucleotides encoding same, transgenic plants expressing same and methods of using same
Nucleic acid constructs are provided. These constructs comprise any of the, nucleic acid sequences at least 85% identical to nucleotide sequences selected from the group consisting of SEQ ID NOs: 68, 1, 4, 5, 8, 9, 11, 13, 16, 19, 20, 23, 24, 27, 30, 32, 37, 42, 49, 50, 51, 53, 54, 55, 56, 57, 58, 64, 69, 70, 73, 77, 78, 79, 80, 84, 86, 87, 93, 94, 98, 101, 102, 103, 104, 105, 106, 107, 108 and 109 and a promoter sequence capable of directing transcription of said nucleic acid sequence in a host cell. Also provided are transgenic plants expressing these nucleic acid constructs and methods of using same.
US08962914B2 Genotypes, alleles and molecular markers associated with asian soybean rust, as well as methods, processes and uses thereof
The present invention relates to screening methods for rust resistance or tolerance, in particular, Asian soybean rust (ASR—Phakopsora pachyrhizi). In addition, the present invention relates to the use of molecular markers for the Glycine genus, in particular, for the Glycine max species. The present invention further relates to a method for identifying loci with quantitative and/or qualitative traits associated with rust resistance or tolerance in plants by means of molecular markers. Said markers can be used for assisted screening in improvement programs directed to selecting disease-resistant or -tolerant plants. The present invention also relates to gene pyramiding related to rust resistance. The markers of the present invention are also useful for the positional cloning of rust-resistant or -tolerant genes. Also disclosed are a method for obtaining disease-resistant or -tolerant cultivars, a process for obtaining a plant population and a method for controlling diseases in a plant population. Another object of the present invention is the use of species from the Glycine genus as a source of resistance for obtaining ASR-resistant or tolerant cultivars.
US08962912B2 Transgenic non-human animals expressing human blood clotting factors and uses thereof
The present invention relates, in general, to development of non-human transgenic animals expressing a human blood clotting factor, such as Factor VIII, Factor VII, Factor IX and von Willebrand factor. The invention further provides methods of detecting immunogenic events against human blood clotting factor using the transgenic animals described.
US08962909B2 Moisture detecting module and a receiving unit
The invention relates to a moisture detecting module for monitoring a moisture state of a napkin. The module comprises a moisture sensitive sensor and a moisture non-permeable layer covering the sensor. The moisture non-permeable layer is arranged for attachment to a napkin surface that, during use of the napkin by a person, is facing towards the person's skin such that the moisture sensitive sensor contacts the napkin surface. The moisture detection module is a RLC circuit that acts as a RF-tag thereby transmitting moisture information to a remote reading device.
US08962908B2 Antioxidant and antimicrobial wound dressing materials
A wound dressing material comprising a polymeric substrate, a silver salt, and a dyestuff to photostabilize the silver salt. The substrate may comprise collagen and/or oxidized regenerated cellulose complexed to Ag+, and the dyestuff may for example be an aniline or acridine dye.
US08962905B2 Process for the continuous hydrogenation of triglyceride containing raw materials using a nickel and molybdenum-based catalyst
Process for the continuous hydrogenation of triglyceride containing raw materials in a fixed bed reactor system having several catalyst beds arranged in series and comprising at least one hydrogenation catalyst comprising an active phase constituted by a nickel and molybdenum element. The raw material feed, hydrogen containing gas and diluting agent are passed together through the catalyst beds at hydrogenation conditions. The raw material feed stream as well as the stream of hydrogen containing gas are divided into an equal number of different partial streams. These are each passed to one catalyst bed in such a manner that the weight ratio of diluting agent to raw material feed is essentially the same at the entrance of all catalyst beds and does not exceed 4:1. The claimed process is preferably conducted at low temperatures and allows the utilization of existing units due to the low recycle ratio.
US08962904B2 Catalytic composition for production of alpha-olefins
Catalytic composition for producing an alpha-olefin and methods of making same. The catalytic composition includes a gamma-alumina substrate dopes with at least one element consisting of bismuth, copper, gallium, phosphorus, tin, and zinc, an amount of each element being within a range of from 150 parts per million to 1000 parts per million relative to a total doped weight of the gamma-alumina substrate. Additionally, at least one element is combined with at least one element consisting of cesium, lithium, and magnesium, an amount of each element being within the range of from 150 parts per million to 1000 parts per million relative to the total doped weight of the gamma-alumina substrate.
US08962898B2 Optically active ammonium salt compound, production intermediate thereof, and production method thereof
An optically active bisbenzyl compound or a racemic bisbenzyl compound represented by formula (2) that has axial chirality: where: R1 represents a halogen, or an optionally substituted: linear, branched, or cyclic C1-8 alkyl, C2-8 alkenyl, C2-8 alkynyl, C6-14 aryl, C3-8 heteroaryl, linear, branched, or cyclic C1-8 alkoxy, or C7-16 aralkyl; R21 each independently represents hydrogen, halogen, nitro, or an optionally substituted: linear, branched, or cyclic C1-8 alkyl, C2-8 alkenyl, C2-8 alkynyl, C6-14 aryl, linear, branched, or cyclic C1-8 alkoxy, or a C7-16 aralkyl; R3 represents hydrogen, or an optionally substituted: C6-14 aryl, a C3-8 heteroaryl, or a C7-16 aralkyl; and Y2 represents a halogen, or an optionally substituted: C1-8 alkylsulfonyloxy, C6-14 arylsulfonyloxy, or C7-16 aralkylsulfonyloxy.
US08962894B2 Process for preparing 1, 6-hexanediol
Disclosed are processes for preparing 1,6-hexanediol and synthetic intermediates useful in the production of 1,6-hexanediol from renewable biosources. In one embodiment, a process comprises contacting levoglucosenone with hydrogen in the presence of a first hydrogenation catalyst at a first temperature to form product mixture (I); and heating product mixture (I) in the presence of hydrogen and a second hydrogenation catalyst at a second temperature to form product mixture (II) which comprises 1,6-hexanediol.
US08962893B2 Organometallic compound purification
Methods of purifying crude cyclopentadienyl magnesium compounds using a scavenging agent are provided. The purified cyclopentadienyl magnesium compounds have very low levels of metallic impurities.
US08962889B2 Process for producing optically active β-amino aldehyde compound
The invention relates to a method of producing optically active β-aminoaldehyde compound (3) by reacting imine compound (1-1) or sulfone compound (1-2) with aldehyde compound (2) in the presence of an optically active pyrrolidine compound. wherein each symbol is as defined in the specification.
US08962888B2 Forming spherical crystal habit
Methods for forming spherical crystal habit are shown. A needle-shaped crystal habit, a solvent, and a surfactant are combined and dissolved forming a first solution. The first solution and an anti-solvent are combined forming a second solution. The second solution is cooled. Spherical crystal habit is formed.
US08962885B2 β-hydroxyalkylamides, a method for production of same and use of same
The invention relates to new β-hydroxyalkylamides, to a method for production of same and to the use of same.
US08962884B2 Method for preparing a complex of an acid and a metal
The invention concerns a method for preparing a complex of an acid chosen from among methionine, 2-hydroxy-4-methylthiobutanoic acid (HMTBA) and lactic acid, and of at least one metal, starting from said acid and a mineral metal source, wherein the acid is caused to react with the mineral metal source in an extruder.
US08962881B2 Oxidized organic compound manufacturing method
The disclosed invention is a method for manufacturing an oxidized organic compound which includes a step of forming an oxidized organic compound, in use of a fixed-bed reactor having a reaction tube packed with an oxide catalyst, by supplying at least one type of organic compound as a reaction feedstock gas and using a molecular oxygen-containing gas to carry out a catalytic gas-phase oxidation reaction; and a step of stopping the catalytic gas-phase oxidation reaction. In the manufacturing method, when stopping the catalytic gas-phase oxidation reaction, the supply of the reaction feedstock gas is stopped, after which an inert gas is supplied to the reactor, then a molecular oxygen-containing gas is supplied, subsequent to which the supply of the molecular oxygen-containing gas to the reactor is stopped.
US08962879B2 Perfluoropolyvinyl modified aryl intermediates/monomers
A compound of formula (I) wherein Rf is —CF3, —C2F5, —CF2CFXCF3; X to —F, or —OC3F7; Y is —H, —Cl, or —Br; R is —O—C(O)—R1, —(CH2)nO—C(O)—R1, —(OCH2CH2)mOC(O)—R1; —(CH2)n(OCH2CH2)mO—R1; n is 1 to 10; m is 1 to 10; R1 is —C(R3)═CH2; R3 is H or CH3; a is 1 to 5; and b is 1 to 5.
US08962876B2 Thermally stable volatile film precursors
A precursor for the deposition of a thin film by atomic layer deposition is provided. The compound has the formula MxLy where M is a metal and L is an amidrazone-derived ligand or an amidate-derived ligand. A process of forming a thin film using the precursors is also provided.
US08962871B2 Method for producing 4-benzyl-1-methyl-6-oxabicyclo[3,2,0]heptane derivative
A 4-benzyl-1-methyl-6-oxabicyclo[3,2,0]heptane derivative is manufactured by reducing, in the presence of both a halogenating agent and a hydride-type reducing agent, a methylene moiety bound to a sulfonyloxy group in a compound represented by General Formula (II).
US08962870B2 9, 10-α, α-OH-taxane analogs and methods for production thereof
Provided herein are compounds, compositions containing the compounds, and methods for the treatment of cancer in a cancer patient. In particular, the compounds are made by a process comprising treating a first compound represented by either Formula G′ or Formula M′: with a second compound of generalized formula R8R9C(OCH3)2 and an acid selected from the group consisting of camphor sulfonic acid (CSA), p-toluene sulfonic acid (PTSA), hydrochloric acid (HCl) and acetic acid (AcOH), wherein R1 and R2 are each selected from H, an alkyl group, an olefinic group, an aromatic group, an O-alkyl group, an O-olefinic group, or an O-aromatic group; R7 is an alkyl group, an olefinic group, or an aromatic group; P1 is a hydroxyl protecting group; P5 is H or an acid labile protecting group at the 7-O position; R8 is H, alkyl group, olefinic or aromatic group; and R9 is: H, alkyl group, olefinic or aromatic or is as defined in the specification.
US08962864B2 Process for preparing 4-amino-5-biphenyl-4-yl-2-hydroxymethyl-2-methyl-pentanoic acid compounds
The invention provides processes for preparing intermediates useful for preparing compounds of the formula: or a tautomer or salt thereof, where R1-R5, a, b, X and P2, are as defined in the specification.
US08962863B2 Process for the synthesis of substituted gamma lactams
The present invention provides synthetic processes for the preparation of a variety of well-defined substituted gamma lactams. The compounds that can be prepared by the process of the invention are useful for treating a variety of conditions. In some embodiments of the invention, the compounds are useful for treating ocular disorders, such as, for example, glaucoma, lowering of elevated intraocular pressure, and the like. In other embodiments, the compounds are useful for treating irritable bowel disease. In further embodiments, the compounds are useful in promoting hair growth. In still further embodiments, the compounds are useful in promoting wound healing, scar reduction, and the like.
US08962861B2 Catalyst composition and method for preparing amide
The present invention provides a catalyst composition and a method for preparing an amide. The catalyst composition of the present invention including a hydroxylamine salt, sulfuric acid, and a nitrogen-containing heterocyclic compound is used for catalyzing a ketoxime to form an amide in the Beckman rearrangement reaction. The preparation of an amide by using the catalyst composition of the present invention has high conversion rate of a ketoxime, high selectivity of an amide and high tolerance to water.
US08962859B2 Spiro-amino-imidazo-fused heterocyclic compounds as beta-secretase modulators and methods of use
The present invention provides a new class of compounds useful for the modulation of beta-secretase enzyme (BACE) activity. The compounds have a general Formula I: wherein variables A1, A3, A5, A6, A8, R2, R7, X, Y and Z of Formula I are defined herein. The invention also provides pharmaceutical compositions comprising the compounds, and corresponding uses of the compounds and compositions for treatment of disorders and/or conditions related to plaque formation and deposition, resulting from the activity of BACE. Such BACE mediated disorders include, for example, Alzheimer's Disease, cognitive deficits and impairments, schizophrenia and other central nervous system conditions and disorders. The invention further provides compounds of Formulas II and III, and of sub-formulas of Formulas I, II and III, intermediates and processes and methods useful for the preparation of compounds of Formulas I-III.
US08962853B2 Chemical probe compounds that become fluorescent upon reduction, and methods for their use
Chemical stain compounds containing a fluorophore and a reducible quenching unit are disclosed. The reducible quenching unit quenches the fluorophore while in its oxidized state. Upon reduction, the quenching properties of the quenching unit are diminished or eliminated. The chemical compounds can be used in a variety of applications, including the detection of bacterial cells, monitoring the electron transport chain function of bacterial cells, monitoring the oxidation state of non-biological systems, and assaying the effectiveness of antibacterial or antimicrobial agents.
US08962850B2 Nitrogen-containing heterocyclic compound and method for producing same
There are provided a nitrogen-containing heterocyclic compound such as a substituted amino-pyridine-N-oxide compound represented by formula (1), which is useful as a synthetic intermediate for an agrochemical and the like; and a method for producing the nitrogen-containing heterocyclic compound. (In formula (1), R1 and R2 each represents a hydrogen atom or an unsubstituted or substituted alkyl group; R3 represents a hydrogen atom, an unsubstituted or substituted alkylcarbonyl group or the like; R4 represents an unsubstituted or substituted alkylcarbonyl group, an unsubstituted or substituted arylcarbonyl group or the like; A represents a hydroxyl group, a thiol group or the like; m represents any one of integers of 1 to 4; k represents any one of integers of 0 to 3; and k+m≦4.)
US08962849B2 Nitrogen-containing heterocyclic compound and method for producing same
There are provided a nitrogen-containing heterocyclic compound such as a substituted amino-pyridine-N-oxide compound represented by formula (1), which is useful as a synthetic intermediate for an agrochemical and the like; and a method for producing the nitrogen-containing heterocyclic compound. (In formula (1), R1 and R2 each represents a hydrogen atom or an unsubstituted or substituted alkyl group; R3 represents a hydrogen atom, an unsubstituted or substituted alkylcarbonyl group or the like; R4 represents an unsubstituted or substituted alkylcarbonyl group, an unsubstituted or substituted arylcarbonyl group or the like; A represents a hydroxyl group, a thiol group or the like; m represents any one of integers of 1 to 4; k represents any one of integers of 0 to 3; and k+m≦4.).
US08962844B2 1,3,4-oxadiazole and 1,3,4-thiadiazole β-lactamase inhibitors
β-Lactamase inhibitor compounds (BLIs) are disclosed, including compounds that have activity against class A, class C or class D β-lactamases. Methods of manufacturing the BLIs, and uses of the compounds in the preparation of pharmaceutical compositions and antibacterial applications are also disclosed.
US08962840B1 Electroactive polymer based supercapacitors including a cathode having BBL or Pry-BBL
A process used to cast films including: mixing BBL and a room temperature molten salt from a range of about 35:65 weight ratio, dissolving the mixture in about 1% methanesulfonic acid to produce a BBL solution, drop casting the solution onto glass or gold coated glass at 140° C. in air and heating for about 2 hours to produce films, drying the films in a vacuum oven at about 100° C. for at least 24 hours under dynamic vacuum, and rinsing the films to remove residual ionic liquid.
US08962839B2 Chiral spiro-pyridylamidophosphine ligand compound, synthesis method therefor and application thereof
The present invention relates to a chiral spiro-pyridylamidophosphine ligand compound, synthesis method therefor and application thereof. The chiral spiro-pyridylamidophosphine compound is a compound having a structure of Formula (I), a racemate or optical isomer thereof, or a catalytically acceptable salt thereof, and is mainly characterized by having a chiral spiro-dihydro-indene skeleton in its structure. The chiral spiro-pyridylamidophosphine compound may be synthesized with optical active 7-diaryl/alkylphosphino-7′-amino-1,1′-spiro-dihydro-indene or substituted 7-diaryl/alkylphosphino-7′-amino-1,1′-spiro-dihydro-indene having a spiro-skeleton as chiral starting material. The chiral spiro-pyridylamidophosphine compound may be used as a chiral ligand in asymmetric hydrogenation of a carbonyl compound catalyzed by iridium, in which the reaction activity is very high, the amount of the catalyst may be 0.0001 mol %, and the enantioselectivity of the reaction is up to 99.9% ee.
US08962836B2 Formation of N-protected bis-3,6-(4-aminobutyl)-2,5-diketopiperazine through a cyclic alpha-N-protected amino ester
A method for the synthesis of N-protected 3,6-aminoalkyl-2,5-diketopiperazines is provided. The method includes obtaining a cyclic α-N protected active amino ester and adding it to a mixture of an amine catalyst in an organic solvent.
US08962830B2 Protein kinase inhibitors and methods of treatment
The present invention relates to chemical compounds of formula (I) and methods for their use and preparation. In particular, the invention relates to substituted pyrazolo[3,4-d]pyrimidine based compounds which can be used in treating proliferative disorders, use of these compounds in methods of therapy and the manufacture of medicaments as well as compositions containing these compounds.
US08962829B1 Morphic forms of hexadecyloxypropyl-phosphonate esters and methods of synthesis thereof
The disclosure describes methods of synthesis of phosphonate ester compounds. The methods according to the disclosure allow for large-scale preparation of phosphonate ester compounds having high purity and stability. Also disclosed are morphic forms of phosphonate ester compounds.
US08962827B2 Linezolid intermediate and method for synthesizing linezolid
Provided are a linezolid intermediate and the preparation method thereof and a method for synthesizing linezolid. The structure of the intermediate is shown as formula F2, wherein the compound is prepared by a condensation reaction of (S)—N-(3-chloro-2-hydroxy-1-propyl) acetamide and the compound shown in formula F4. In the preparation methods of the compound shown in formula F2 and linezolid, the reaction system is mild, side reactions are few and the product yield is high.
US08962821B2 Method for preparing regenerated cellulose fiber by two-step coagulating bath process
The present invention relates to a non-toxic process and system for pilot-scale production of cellulose products, and particularly to a process and system for pilot-scale production of cellulose products by using aqueous sodium hydroxide/urea solution pre-colled to lower than −8° C., in which cellulose could dissolved rapidly. The said process and system can be used to produce fibers, films, chromatographic packings, or nonwovens of regenerated cellulose, as well as to produce a variety of high added-value products by adding other materials such as functional materials, nano-materials, etc.
US08962815B2 Bis-azo colorants for use as bluing agents
This invention relates to bis-azo colorants for use as bluing agents, laundry care compositions comprising bis-azo colorants that may serve as bluing agents, processes for making such bluing agents and laundry care compositions and methods of using the same. The bluing agents are generally comprised of at least two components: at least one chromophore component and at least one polymeric component. These bluing agents are advantageous in providing a whitening effect to fabrics, while not building up over time and causing undesirable blue discoloration to the treated fabrics.
US08962813B2 Purification and use of a factor for supporting wound healing
A process for manufacturing of a composition containing a purified factor for supporting wound healing selected from the group consisting of Hepatocyte Growth Factor (HGF) platelet derived growth factor (PDGF), Epidermal growth factor (EGF), transforming growth factor alfa (TGF-α), Transforming growth factor beta (TGF-β), insulin like growth factor (IGF-I) and Fibroblast growth factor (FGF) from sources, such as blood, containing the factor for supporting wound healing, wherein the manufacturing process comprises purification steps which are performed in the presence of antithrombin III (AT-III).
US08962812B2 Methods of extracting chemical compounds from organisms with resistant cell walls
A method is provided for extraction of chemical compounds from an organism having a cell wall that includes adding nanomaterials, which may be metallic nanofibers such as silver nanofibers, to the organism.
US08962811B2 Growth hormone and interferon-alpha 2 glycoproteins produced in plants
Methods of increasing the yield in plant expression of recombinant proteins comprising engineering glycosylation sites into cloned genes or cDNAs for proteins using codons that drive post-translational modifications in plants; and engineering the cloned genes or cDNAs to contain a plant secretory signal sequence that targets the gene products (protein) for secretion. The methods result in increased recombinant glycosylated protein yields. Proteins produced according to these methods are disclosed.
US08962805B2 Anti IL-6R polypeptides and compositions thereof
The present invention relates to amino acid sequences that are directed against/and or that can specifically bind Interleukin-6 Receptor (IL-6R) with improved affinity and/or avidity, and/or that have an improved efficacy and/or potency, and which are capable of (partially, or preferably totally) blocking the IL-6/IL-6R interaction and/or inhibit signalization through IL-6, IL-6R and/or the IL-6/IL-6R complex. The invention further relates to compounds or constructs, and in particular proteins and polypeptides, that comprise or essentially consist of one or more such amino acid sequences. The invention also relates to nucleic acids encoding such amino acid sequences and polypeptides, to methods for preparing such amino acid sequences and polypeptides, to host cells expressing or capable of expressing such amino acid sequences or polypeptides, to compositions, and in particular to pharmaceutical compositions, that comprise such amino acid sequences, polypeptides, nucleic acids and/or host cells, and to uses of such amino acid sequences or polypeptides, nucleic acids, host cells and/or compositions, in particular for prophylactic, therapeutic or diagnostic purposes.
US08962804B2 Meditopes and meditope-binding antibodies and uses thereof
Antibodies and meditopes that bind to the antibodies are provided, as well as complexes, compositions and combinations containing the meditopes and antibodies, and methods of producing, using, testing, and screening the same, including therapeutic and diagnostic methods and uses.
US08962802B2 Methods for purification of alpha-1-antitrypsin and apolipoprotein A-1
This invention relates to protein separation and purification methods for both alpha-1-antitrypsin (AAT, also known as alpha-1 proteinase inhibitor, API, and A.sub.1-PI) and Apolipoprotein A-I (ApoA-1) from, for example, a fraction of human blood plasma. In certain embodiments, the invention provides methods for separating AAT from ApoA-1 at the initial stage of purification, so that the same starting material can be used as a source for both proteins. The methods further pertain to providing compositions of AAT and of ApoA-1 suitable for pharmaceutical use and are suitable for large-scale purification.
US08962800B2 Nucleic acids and proteins and methods for making and using them
The invention provides polypeptides, including enzymes, structural proteins and binding proteins, polynucleotides encoding these polypeptides, and methods of making and using these polynucleotides and polypeptides. Polypeptides, including enzymes and antibodies, and nucleic acids of the invention can be used in industrial, experimental, food and feed processing, nutritional and pharmaceutical applications, e.g., for food and feed supplements, colorants, neutraceuticals, cosmetic and pharmaceutical needs.
US08962798B2 Peptide fragments for inducing synthesis of extracellular matrix proteins
Short biologically active tetrapeptides are disclosed that are comprised of the sequences GxxG and PxxP where G (glycine) and P (proline) are maintained and x is a variable amino acid. The peptides can be used singly or in combination to stimulate production of extracellular matrix proteins in skin. A rapid, low-cost method of producing heterogenous formulations of tetrapeptides is disclosed.
US08962794B2 Insulins with an acyl moiety comprising repeating units of alkylene glycol containing amino acids
Acylated insulins wherein an acyl moiety is attached to the parent insulin and wherein said acyl moiety comprises repeating units of alkylene glycol containing amino acids and wherein there is only one lysine residue (K & Lys) in the parent insulin have satisfactory properties when administered pulmonary.
US08962793B2 ErbB interface peptidomimetics and methods of use thereof
Peptides, mimetics and antibodies of erbB, TNF, and IgSF receptors and pharmaceutical compositions comprising the same are described. Methods of using such antibodies, peptides, and mimetics in therapeutic, prophylactic, imaging and diagnostic applications are disclosed.
US08962792B2 Process for preparing epoxy resins
A process for preparing an aliphatic or cycloaliphatic epoxy resin including the steps of: (I) reacting a mixture of (a) an aliphatic or cycloaliphatic hydroxyl containing material, (b) an epihalohydrin, (c) a basic acting substance, (d) a non-Lewis acid catalyst, and (e) optionally, a solvent, forming an epoxy resin composition; (II) subjecting the epoxy resin composition produced in step (I) to a separation process to remove (A) “light” components such as, for example, solvent used in the epoxidation reaction, if any, unreacted epihalohydrin, and co-products such as di(epoxypropyl)ether; (B) unreacted aliphatic or cycloaliphatic hydroxyl containing material, if any; (C) partially epoxidized aliphatic or cycloaliphatic hydroxyl containing material, such as, for example, MGE; (D) fully epoxidized aliphatic or cycloaliphatic hydroxyl containing material, such as, for example, DGE, such that the (E) aliphatic or cycloaliphatic polyfunctional epoxy resin product remaining contains no more than 50% by weight of said fully epoxidized aliphatic or cycloaliphatic hydroxyl containing material (D); and (III) recycling the isolated partially epoxidized aliphatic or cycloaliphatic hydroxyl containing material (C) and any mixtures of partially epoxidized aliphatic or cycloaliphatic hydroxyl containing material (C) with fully epoxidized aliphatic or cycloaliphatic hydroxyl containing material (D) from step (II) to a new reaction mixture of step (I).
US08962790B2 Polyimide film and process for producing the same
A process includes the steps of: casting or coating a polyamic acid organic solvent solution on a support and drying the polyamic acid organic solvent solution thereon, so as to form a partially cured and/or partially dried polyamic acid film; dipping the polyamic acid film in tertiary amine or a solution of tertiary amine, or coating tertiary amine or a solution of tertiary amine on the polyamic acid film; and drying the film while imidizing the polyamic acid. In another process, a chemical converting agent and a catalyst are mixed in an organic solvent solution of polyamic acid. After casting and heating the mixture on a support, a partially cured and/or partially dried polyamic acid film is detached from the support. The film contains, with respect to the remaining volatile component, not less than 50 parts of catalyst, not more than 30 parts of solvent, and not more than 20 parts of chemical converting agent and/or a chemical converting agent derived component. The remaining amic acid is imidized and the film is dried.
US08962787B2 Continuous process for the production of melt polycarbonate
A method for producing polycarbonate by melt polymerization can comprise: (a) adding acetone, diaryl carbonate, and dihydroxy compound to the melt polymerization unit, wherein the acetone is added to the melt polymerization unit as a mixture with the diaryl carbonate and/or the dihydroxy compound; (b) adding a catalyst to the melt polymerization unit, optionally without separating out acetone prior to the addition of the catalyst; and (c) operating the melt polymerization unit under conditions so that the diaryl carbonate(s) and dihydroxy compound(s); dihydroxy compound reacts with the diaryl carbonate to produce polycarbonate with a desired specification, and a phenol by-product.
US08962785B2 Polyisobutylene-based polyurethanes
An elastomeric polymer, comprising (1) a hard segment in the amount of 10% to 60% by weight of the elastomeric polymer, wherein the hard segment includes a urethane, urea or urethaneurea; and (2) a soft segment in the amount of 40% to 90% by weight of the elastomeric polymer. The soft segment comprises (a) at least 2% by weight of the soft segment of at least one polyether macrodiol, and/or at least one polycarbonate macrodiol; and (b) at least 2% by weight of the soft segment of at least one polyisobutylene macrodiol and/or diamine.
US08962779B2 Method of forming polyaryl polymers
In a method of forming a polyacetal or polyketal, a specific acetal- or ketal-containing bis(aryl)acetal is coupled with itself or a comonomer in the presence of a catalyst and a base. The polymerization reaction tolerates hydroxyl and other functional groups on the bis(aryl)acetal. Among other applications, the polyacetals and polyketals are useful components of photoresist compositions.
US08962778B2 Cellulose resin and method for producing the same
A cellulose resin produced by binding cardanol or a derivative thereof and abietic acid or a derivative thereof to cellulose or a derivative thereof.
US08962774B2 Attrition resistant catalyst system for manufacture of polyolefins
Regular shaped magnesium particles containing attrition resistant precursors and procatalysts thereof and processes for their synthesis and their use in the manufacture of polyolefins are described. A process for the synthesis of precursor particles which give highly active and improved surface area procatalysts for producing high bulk density polyolefin resins containing low fines and capable of incorporating high rubber content are described. A process for the synthesis of an attrition resistant precursors to prepare an attrition resistant Zeigler Natta procatalysts synthesized by using the precursors and to the polyolefin resin synthesized using the procatalysts is also described.
US08962773B2 Phosphorus-containing compounds useful for making halogen-free, ignition-resistant polymers
Phosphorus-containing compounds useful for flame retardant epoxy resins are disclosed. The flame retardant epoxy resins may be used to make electrical laminates. This invention is particularly useful in end use applications in which a low bromine or low halogen content is required or desired.
US08962772B2 Antimicrobial surface modified silicone rubber and methods of preparation thereof
An antimicrobial silicone rubber comprises a silicone rubber substrate, a catechol layer bound to a surface of the silicone rubber substrate, and an antimicrobial layer disposed on the catechol layer. The catechol layer comprises a catechol material, a quinone derivative thereof, and/or a polymer of the foregoing catechol material and/or quinone derivative. The antimicrobial layer comprises an antimicrobial cationic polycarbonate covalently linked to the catechol layer.
US08962769B2 Polyimidothioethers-inorganic nanoparticle hybrid material, intermediate thereof and their preparation
The present invention relates to novel polyimidothioethers-inorganic nanoparticle hybrid material, which exhibit good surface planarity, thermal dimensional stability, tunable refractive index, and high optical transparency upon forming into films. The present invention also relates to polyimidothioethers which is an intermediate for preparing the present hybrid material, and their preparation.
US08962767B2 Isobutylene copolymer with grafted polymer groups
Disclosed are copolymers which comprise: a) an isobutylene copolymer having grafted polymer groups, b) optionally a tackifier, and c) optionally a non-functionalized poly(isobutylene) polymer. The compositions are useful in adhesives and coatings.
US08962766B2 Polymers functionalized with polyhydrazone compounds
A method for preparing a functionalized polymer, the method comprising the steps of: (i) polymerizing monomers to form a reactive polymer, and (ii) reacting the reactive polymer with a protected polyhydrazone compound.
US08962758B2 Thermoplastic elastomer composition and medical rubber product
The present invention aims to provide a dynamically-crosslinked thermoplastic elastomer composition that can provide a molded product exhibiting low compression set especially in the case of being cooled under stress. The present invention relates to a thermoplastic elastomer composition, including a dynamically-crosslinked butyl rubber and a thermoplastic resin; and having a thermoplastic resin content of not more than 8% by mass. The dynamically-crosslinked butyl rubber is preferably a halogen-containing butyl rubber.
US08962757B2 Graft polymers for enhanced intracellular delivery of antisense molecules
Innovative graft polymers designed for the efficient delivery of antisense molecules into biological cells and for maintaining the biological activity of these molecules while in serum and other aqueous environments are provided. Such polymers may comprise an anionic graft polymer comprising an anionic polymer backbone with pendant carboxylic acid groups and pendant chains comprising amphipathic or hydrophilic polymers covalently bonded to a portion of said pendant carboxylic acid groups. Antisense molecule delivery vectors comprising such polymers in combination with cationic agents for delivery of antisense molecules are also disclosed.
US08962756B2 Polymer alloy, process for producing same, and molded article
At least two or more components of thermoplastic resins are compounded by chaotic mixing to form a polymer alloy with a sophisticatedly controlled dispersed phase structure. In the polymer alloy, a dispersed phase having a non-periodic structure with a correlation length of 0.001 μm to 0.5 μm and having a compactness (C) of 0.05≦(C)≦0.8, wherein the compactness (C) can form a molded product that also has transparency while maintaining the original good heat resistance or mechanical properties of the resins blended.
US08962755B2 Polyethylene compositions and closures for bottles
A dual reactor solution process gives high density polyethylene compositions containing a first ethylene copolymer and a second ethylene copolymer and which have good processability, toughness, and environmental stress crack resistance combined with good organoleptic properties. The polyethylene compositions are suitable for compression molding or injection molding applications and are particularly useful in the manufacture of caps and closures for bottles.
US08962754B2 Nonaqueous electrolyte solution and lithium ion battery
A nonaqueous electrolyte and a lithium ion battery with reduced temporal variations in battery characteristics from initial values are provided. A mixed solution is prepared by dissolving a lithium salt such as LiPF6 in a nonaqueous solvent such as ethylene carbonate. Allylboronate ester and siloxane are mixed with the mixed solution. The content of the allylboronate ester is 1 wt % or less. The content of the siloxane is 2 wt % or less. 2-Allyl-4,4,5,5-tetramethyl-1,3,2-dioxaborolane is used as the allylboronate ester. At least one kind selected from hexamethyldisiloxane and 1,3-divinyltetramethyldisiloxane is used as the siloxane.
US08962752B2 Rubber composition and tire using the same as well as modified conjugated diene-based polymer and method for producing the same
This invention relates to a rubber composition being excellent in the low heat buildup and fracture properties (resistance to crack growth). and more particularly to a rubber composition, characterized by compounding 10-100 parts by mass of an inorganic filler and/or carbon black based on 100 parts by mass of a rubber component including not less than 10 mass % of a modified conjugated diene-based polymer having a cis-1,4 bond content of not less than 90% and a vinyl bond content of not more than 1.2% and a primary amino group. In this case, the modified conjugated diene-based polymer is obtained by (1) reacting the predetermined conjugated diene-based polymer having an active terminal with a compound having two or more predetermined functional groups and (2) further reacting the resulting product with a compound having a primary amino group.
US08962744B2 Copolymer, rubber composition, crosslinked rubber composition and tire
The present invention provides a random copolymer that is used for manufacturing a tire having excellent rollability and wear resistance and that includes randomly arranged monomer units of a conjugated diene compound and of a non-conjugated olefin, a rubber composition containing the random copolymer, a cross-linked rubber composition obtained by crosslinking the rubber composition, and a tire manufactured by using the rubber composition or the cross-linked rubber composition. A copolymer of a conjugated diene compound and a non-conjugated olefin, including a random copolymer having randomly arranged monomer units of the conjugated diene compound and of the non-conjugated olefin, and containing, by more than 30 mol %, a unit derived from the conjugated diene compound.
US08962743B2 Copolymer of conjugated diene compound and non-conjugated olefin, rubber composition and tire
The present invention provides a copolymer of a conjugated diene compound and a non-conjugated olefin, in which the conjugated diene unit has cis-1,4 bonds and the non-conjugated olefin contains many ethylene structures. In a copolymer of a conjugated diene compound and an unconjugated olefin other than the conjugated diene compound, the conjugated diene unit has a cis-1,4 bond content of 50% or more and the unconjugated olefin is contained in an amount of 20 mol % or more.
US08962742B2 Hydrogel-forming composition and hydrogel produced from the same
A hydrogel having mechanical properties and capable of being produced simply by using and mixing an industrially obtainable polymer having high versatility and clay particles, and to provide a method of producing the hydrogel. A hydrogel-forming composition is characterized by containing a polyelectrolyte, clay particles, and a dispersant for the clay particles.
US08962739B2 Liquid crystal alignment agent, and liquid crystal alignment film and liquid crystal display element formed from the liquid crystal alignment agent
A liquid crystal alignment agent includes a polyamic acid dispersion and a polyimide dispersion. Viscosity of the polyamic acid dispersion and viscosity of the polyimide dispersion satisfy the following relationship: VA-2−VA-1≧4 cps wherein VA-2 is viscosity of the polyimide dispersion measured at a solid content of 6 wt % at a temperature of 25° C., and VA-1 is viscosity of the polyamic acid dispersion measured at a solid content of 6 wt % at a temperature of 25° C. A liquid crystal alignment film formed from the liquid crystal alignment agent and a liquid crystal display element including the liquid crystal alignment film are also disclosed.
US08962737B2 Composite coated substrates and moldable composite materials
A moldable composite material contains flakes of composite material, i.e., flakes of polymeric matrix materials having fibers embedded therein. An improved substrate is provided by providing a substrate and applying a coating onto the substrate, the coating containing the flakes of composite material. A first construction member can be secured to a second construction member by applying the coating onto an attachment region of the first construction member, and applying a fastener onto the first construction member in the coated attachment region to secure the first construction member to the second construction member.
US08962731B2 Preparation method of metal nanobelt
This disclosure relates to a method of preparing a metal nanobelt. According to the method, a metal nanobelt having various applicabilities, for example, capable of easily forming a conductive film or a conductive pattern with excellent conductivity, may be easily prepared by a simple process at room temperature and atmospheric pressure. The method comprises reacting a conductive polymer and a metal salt.
US08962728B2 Weathering-resistant, colored moldings with improved gloss and wipe resistance
The present invention relates to weathering-resistant, colored moldings made of poly(alkyl)(meth)acrylate with improved gloss and resistance to mechanical influences acting on the surface of the molding, in particular with improved wipe resistance and improved scratch resistance, and also to molding compositions for producing the same.
US08962725B2 Crosslinkable composition crosslinkable with a latent base catalyst
The present invention relates to a crosslinkable composition comprising at least one crosslinkable component crosslinkable by a latent base crosslinking catalyst comprising a substituted carbonate salt according to formula 1 wherein X+ represents a cation and wherein R is hydrogen, alkyl, aryl or aralkyl group, and wherein the crosslinkable composition comprises 0.1-10 wt %, preferably 0.1-5, more preferably 0.2-3 and most preferably 0.5-1.5 wt % water (relative to total weight of the crosslinkable composition). The invention further relates to a coating composition comprising the crosslinkable composition according to the invention, a novel catalyst composition and to the use of said catalyst composition according to the invention as a latent base crosslinking catalyst in coating compositions, preferably in RMA crosslinkable compositions.
US08962724B2 High solids low volatile organic compounds content ethylene propylene diene terpolymer formulation
A two part low volatile organic compounds (VOC) content ethylene propylene diene terpolymer formulation with a solids content of at least 60 percent solids by volume of the total formulation and a volatile organic compounds content less than 450 grams per liter, wherein a first component has EPDM, a solvent, a curative, an additive, and a blend of a pigment and a filler. The second component contains solvent and a metal drier. The invention includes a method for making the coating and a cured coated substrate with the cured waterproof rubber coating disposed thereon.
US08962716B2 Curable composition
An object of the present invention is to provide a curable composition which is made mainly of a polymer having one or more reactive silicon groups, has good curability even when filler is used while a non-organotin catalyst is used, and is further high in industrial practicability. The object is solved by a curable composition, comprising, as constituents, a polymer (A) having one or more reactive silicon groups on average per molecule thereof, the reactive silicon group(s) being (each) a group which can be crosslinked by forming a siloxane bond, a Lewis acid and/or derivative thereof (B), an amine compound (C), a compound (D) having a reactive silicon group, and filler (E), and obtained by mixing the constituents with each other.
US08962715B2 Stabilized aqueous polymer compositions and their use
Disclosed are stabilized aqueous polymer compositions containing A) a stabilizing amount of a least a sulfur dye or containing a stabilizing amount of a sulfur dye with a compound comprising a heterocyclic system containing nitrogen and sulphur as ring heteroatoms and B) at least one polymer comprising groups which are capable of complex formation with ions. The aqueous polymer compositions are stabilized against thermal or other degradation processes of the polymer by addition of component A) to allow their use even under harsh conditions.
US08962709B2 Resin systems for dental restorative materials and methods using same
The invention includes a new photopolymerizable resin system for dental restorative materials. The resin system utilizes a thiol-ene component as the reactive diluent in dimethacrylate systems. The ternary resin system comprises a thiol monomer, an ene monomer and a dimethacrylate monomer. The system of the invention has enhanced overall functional group conversion, improved polymer mechanical properties, and reduced shrinkage stress of the ternary system when compared to either traditional dimethacrylate or thiol-ene resin systems.
US08962705B2 Material for removing cauxin in cat urine
A method for removing cauxin in cat urine and a material for removing cauxin are provided. The material for removing cauxin in cat urine comprises a polymer substrate on which surface a trifluoroketone derivative is immobilized via dithiol.
US08962702B2 Mixed oxide based catalyst for the conversion of carbon dioxide to syngas and method of preparation and use
The invention relates to a catalyst and process for making syngas mixtures including hydrogen, carbon monoxide and carbon dioxide. The process comprises contacting a gaseous feed mixture containing carbon dioxide and hydrogen with the catalyst, where the catalyst comprises Mn oxide and an auxiliary metal oxide selected from the group consisting of La, Ca, K, W, Cu, Al and mixtures or combinations thereof. The process enables hydrogenation of carbon dioxide into carbon monoxide with high selectivity, and good catalyst stability over time and under variations in processing conditions. The process can be applied separately, but can also be integrated with other processes, both up-stream and/or down-stream including methane reforming or other synthesis processes for making products like alkanes, aldehydes, or alcohols.
US08962701B2 Integrated bioprocessing for fuel production
Systems and methods are provided for enhancing the integration of processes for recovering products from algae-derived biomass. The enhanced process integration allows for increased use of input streams and other reagents that are derived from renewable sources. This increases the overall renewable character of the products extracted from the algae-derived biomass. The process integration can include exchange of input streams or energy between an algae processing system and a system for processing non-algal biomass. One example of improving process integration is using oxygenates that are generated in a renewable manner as a reagent for enhancing the algae processing system.
US08962699B2 Liquid composition to be filled in soft capsules
Disclosed is a liquid composition which is intended to be filled in soft capsules and comprises an oil-insoluble ingredient dispersed in an edible oil, a reactive monoglyceride, and a triglycerol fatty acid ester having a monoester content of 50% or more. The liquid composition to be filled in soft capsules does not comprise bees wax but has a dispersion stability of the oil-insoluble ingredient equal to or higher than that of a conventional composition in which bees wax is used.
US08962698B2 Rebaudioside-mogroside V blends
A composition includes Mogroside V and a Rebaudioside component in a weight ratio ≧1:1 and ≦6:1, wherein the Rebaudioside component consists of one or more compounds selected from the group consisting of Rebaudioside A, Rebaudioside B and Rebaudioside D. A method of purifying a Luo Han Guo extract includes contacting the Luo Han Guo extract with activated carbon and a macroporous polymeric adsorbent resin, an ion exchange resin, or both. A composition includes a Luo Han Guo extract, wherein Mogroside V constitutes from 50 wt % to 75 wt % of the Luo Han Guo extract and the composition includes from 0 to 13 wt % in total relative to the Mogroside V of aromatic glycosides, and from 0 to 15 ppm of semi-volatile organic compounds relative to the Mogroside V.
US08962697B2 Bioreponsive polymers
The invention features biodegradable polymers for the delivery of biologically active agents. The polymers include at least one biologically active agent covalently attached via a polyamide linker susceptible to selective hydrolysis by peptidase enzymes. Hydrolysis of the polyamide linker releases the biologically active agent in vivo.
US08962693B2 Method for the treatment or prevention of lower urinary tract symptoms
This invention concerns a method for treatment or prevention of lower urinary tract symptoms with or without pelvic pain in an individual, said method comprising administering to the individual an effective amount of a selective estrogen receptor modulator, or an isomer, isomer mixture or a pharmaceutically acceptable salt thereof.
US08962690B2 Compositions of dibromomalonamide and their use as biocides
A biocidal composition comprising 2,2-dibromomalonamide and a surface active biocide, and its use for the control of microorganisms in aqueous and water-containing systems.
US08962687B2 Method of treating liver disorders
A compound of Formula (I): or a metabolite thereof, or an ester of the compound of Formula (I) or the metabolite thereof, or a pharmaceutically acceptable salt of each thereof, wherein m, n, X1 and X2 are as defined herein, is useful for inhibiting liver steatosis, lobular inflammation, hepatic ballooning and hepatic scarring.
US08962684B2 Antioxidant composition
Disclosed is a stable and safe antioxidant composition which can be used routinely. Specifically disclosed is an antioxidant composition which contains one or more compounds selected from the group consisting of D-aspartic acid, derivatives and/or salts thereof. The composition may be used for the purpose of suppressing and/or improving skin conditions. The skin conditions may include, but is not limited to, fine wrinkles, a rough skin, a dry skin, a skin cancer, a skin allergy, an inflammation of the skin and a photosensitive dermatosis. The composition may be used for an external preparation for the skin, a food, and a pharmaceutical product for cataract.
US08962683B2 Medium chain fatty acids applicable as anti-microbial agents
The present invention relates to the use of medium chain fatty acids (MCFA), chosen from the group consisting of caproic acid (C6), caprylic acid (C8) and capric acid (C10), salts, derivatives or mixtures thereof, in a total amount by weight comprised between 0.01% and 5% for inhibiting the growth of microbial pathogens.
US08962682B2 Jelly composition
It is intended to provide a composition having at least one effect among the following effects; a plurality of medicinal ingredients can be taken as one preparation and the convenience for patients is excellent; the drug compliance is excellent; the amount of jelly composition to be taken at a time is small; the release of an active ingredient in the digestive tract is excellent; the absorption of an active ingredient to the body is excellent; the storage stability of an active ingredient is excellent; the dispersibility of an active ingredient in the composition is excellent; the storage stability of the composition is excellent; the syneresis of the composition is less, it has an appropriate jelly strength to a degree that does not disintegrate during carrying and before taking and easily disintegrates after taking; the handleability during preparation of the composition is excellent; the portability of the composition is excellent; the feeling of taking the composition is excellent; it has an effect on reducing side effects; and the like. The jelly composition contains a polyvalent unsaturated fatty acid, a second medicinal ingredient, an emulsifying agent and a gelling agent.
US08962680B2 Methods and compositions for treating HIV-associated diarrhea
Presented herein are methods for treating diarrhea by administering to a patient in need thereof, an inhibitor of chloride-ion transport in an amount sufficient to treat diarrhea. Treatment of diarrhea includes the treatment of the diarrhea as well as the pain, abdominal discomfort and other symptoms associated with diarrhea. In one embodiment, the inhibitor of chloride-ion transport is crofelemer.
US08962678B2 Senescence inhibitor
Provision of a drug, a quasi-drug, and a food or beverage, which are effective for senescence inhibition, mitochondrial function improvement, muscle dysfunction inhibition, muscular atrophy inhibition, prevention of a bedridden state, muscle senescence inhibition, or motor function improvement. A senescence inhibitor, a mitochondrial function-improving agent, a muscle dysfunction inhibitor, a muscular atrophy inhibitor, and an agent for preventing a bedridden state, containing a catechin as an effective ingredient. A muscle senescence inhibitor and a motor function-improving agent, containing a catechin and an amino acid as effective ingredients.
US08962675B1 Atrasentan mandelate salts
The present disclosure relates to: (a) mandelate salts of atrasentan, (b) pharmaceutical compositions comprising an atrasentan mandelate salt, and, optionally, one or more additional therapeutic agents; (b) methods of using an atrasentan mandelate salt to treat nephropathy, chronic kidney disease, and/or other conditions; (c) kits comprising a first pharmaceutical composition comprising an atrasentan mandelate salt, and, optionally, a second pharmaceutical composition comprising one or more additional therapeutic agents; (d) methods for the preparation of an atrasentan mandelate salt; and (e) atrasentan mandelate salts prepared by such method.
US08962673B2 Use of melatonin for treating and/or preventing mucositis
The present invention relates to the use of a composition comprising melatonin or a derivative thereof at a proportion of 2.5% to 5% w/v for preparing a pharmaceutical composition for treating and/or preventing mucositis. The mucositis is preferably caused by radiotherapy and/or chemotherapy and preferably refers to oral mucositis.
US08962671B2 Amino-substituted 3-heteroaroylamino-propionic acid derivatives and their use as pharmaceuticals
The present invention relates to compounds of the formula I, wherein A, D, E, G, R10, R11, R30, R40, R50 and R60 have the meanings indicated in the claims, which are valuable pharmaceutical active compounds. They are inhibitors of the protease cathepsin A, and are useful for the treatment of diseases such as atherosclerosis, heart failure, renal diseases, liver diseases or inflammatory diseases, for example. The invention furthermore relates to processes for the preparation of the compounds of the formula I, their use and pharmaceutical compositions comprising them.
US08962670B2 Anti-cancer agents
Described herein are compounds that may be selectively activated to produce active anti-cancer agents in tumor cells. Also disclosed are pharmaceutical compositions comprising the compounds, and methods of treating cancer using the compounds.
US08962668B2 Treatment of length dependent neuropathy
Compositions, and methods of use thereof, are provided for the treatment of painful neuropathy by local or topical delivery of compounds that interact with α-adrenergic receptors, especially an alpha2 adrenergic agonist such as clonidine, to the entire painful area such that the need for systemic dosing is minimized. The compounds are delivered to or adjacent to painful areas in patients with painful length dependent neuropathy, and other neuropathies that affect the pain signaling fibers in the skin. A preferred compound for the treatment of patients with length dependent neuropathy is clonidine applied in a transdermal patch, gel, ointment, lotion, liposomal formulation, cream, or emulsion, wherein the concentration is sufficient to provide an effective dose in the painful area or immediately adjacent areas.
US08962665B2 Thiazole and oxazole kinase inhibitors
The present invention is concerned with substituted azole derivatives that selectively modulate, regulate, and/or inhibit signal transduction mediated by certain native and/or mutant proteine kinases implicated in a variety of human and animal diseases such as cell proliferative, metabolic, allergic, and degenerative disorders. In particular, several of these compounds are potent and selective Flt-3 inhibitors or/and syk inhibitors.
US08962664B2 Selective glycosidase inhibitors and uses thereof
The invention provides compounds of formula (I) for selectively inhibiting glycosidases, prodrugs of the compounds, and pharmaceutical compositions including the compounds or prodrugs of the compounds. The invention also provides methods of treating diseases and disorders related to deficiency or overexpression of O-GlcNAcase, accumulation or deficiency of O-GlcNAc.
US08962656B2 CCR2 antagonists
The present invention relates to novel antagonists for CCR2 (CC chemokine receptor 2) of formula (Ia) and their use for providing medicaments for treating conditions and diseases, especially pulmonary diseases like asthma and COPD.
US08962653B2 Quinolinone-carboxamide compounds as 5-HT4 receptor agonists
The invention provides novel quinolinone-carboxamide 5-HT4 receptor agonist compounds. The invention also provides pharmaceutical compositions comprising such compounds, methods of using such compounds to treat diseases associated with 5-HT4 receptor activity, and processes and intermediates useful for preparing such compounds.
US08962649B2 Multidose package, course and method of treatment for delivering predetermined multiple doses of a pharmaceutical
A multidose package containing an imiquimod formulation suitable for treating topical conditions includes: a) a dispensing aperture for dispensing the formulation from the package; b) a reservoir containing sufficient formulation to provide two or more doses; c) a metered dosage element for measuring a predetermined dose of the formulation, the element including an inlet from the reservoir and an outlet to the dispensing aperture; and d) an actuating element operating the dosage element so the predetermined dose is delivered to the dispensing aperture; wherein the dose is dispensed without microbial or other contamination or degradation of the formulation in reservoir. A corresponding course of treatment for various maladies includes providing a multidose package containing an imiquimod formulation suitable for the treatment. A corresponding method of treatment of diseases with multiple doses of an imiquimod formulation includes multiple doses provided by a multidose package.
US08962647B1 Conjugate of polyethylene gylcol and naloxone and pharmaceutical composition and use thereof
Provided are a PEG-naloxone conjugate of general formula (II) and a pharmaceutical composition comprising the conjugate. In the conjugate, n is an integer in the range of 1-20. Also provided is a three-branched or four-branched conjugate of PEG and naloxone. Structural modification of naloxone with a hydrophilic polymer improves the pharmacokinetic properties of the drug, increase the water solubility of naloxone, improve the in vivo distribution of the drug, reduce the side effects of naloxone on central nervous system, and relieve bowel dysfunction and constipation caused by chronic administration of opioids. Also provided are a pharmaceutical composition comprising the conjugate of the invention and use of the conjugate.
US08962646B2 Peripherally acting opioid compounds
The invention relates to a compound of Formula I, II, III, IV or a pharmaceutically acceptable ester or prodrug thereof:
US08962643B2 Compositions and methods for inhibition of the JAK pathway
The invention encompasses compounds having formula I and the compositions and methods using these compounds in the treatment of conditions in which modulation of the JAK pathway or inhibition of JAK kinases, particularly JAK3, are therapeutically useful.
US08962641B2 Pyrimidine-substituted pyrrolidine derivatives, pharmaceutical compositions and uses thereof
The invention relates to new pyrrolidine derivatives of the formula wherein R1 to R3, Ar, L T and n are as defined in the description and claims, to their use as medicaments, to methods for their therapeutic use and to pharmaceutical compositions containing them.
US08962635B2 Tyrosine kinase inhibitors
The present disclosure provides compounds and pharmaceutically acceptable salts thereof that are tyrosine kinase inhibitors, in particular BLK, BMX, EGFR, HER2, HER4, ITK, TEC, BTK, and TXK and are therefore useful for the treatment of diseases treatable by inhibition of tyrosine kinases such as cancer and inflammatory diseases such as arthritis, and the like. Also provided are pharmaceutical compositions containing such compounds and pharmaceutically acceptable salts thereof and processes for preparing such compounds and pharmaceutically acceptable salts thereof.
US08962634B2 4-amino-3-arylamino-6-arylpyrazolo[3,4-d) pyrimidine derivatives, methods for their preparation and their use as antiviral agents
4-amino-3-arylamino-6-arylpyrazolo[3,4-d]pyrimidine derivatives of general formula (I), pharmaceutically acceptable salts thereof, method for preparation of the aforesaid compounds and their use as antiviral agents.
US08962633B2 Methods of treatment and prevention of metabolic bone diseases and disorders
The present invention provides compostions and methods useful for treating and preventing metabolic bone diseases and disorders by inhibition of Lp-PLA2. The compositions and methods are useful for treating and preventing metabolic bone diseases and disorders such as, for example osteoporosis, osteopenia and osteopenia related diseases and abnormal bone marrow.
US08962625B2 Pyridazinone compound and use thereof
A pyridazinone compound represented by the formula (I) has excellent effect on weed control and is useful as an active ingredient of herbicides.
US08962622B2 Benzotriazole kinase modulators
Compounds of formula I modulate jnk and cdk: or a pharmaceutically acceptable salt thereof, where R, R1, R2, R3, and m are defined herein.
US08962619B2 Substituted imidazopyridinyl-aminopyridine compounds
The present invention relates to substituted imidazopyridinyl-aminopyridine compounds and methods of synthesizing these compounds. The present invention also relates to pharmaceutical compositions containing substituted imidazopyridinyl-aminopyridine compounds and methods of treating cell proliferative disorders, such as cancer, by administering these compounds and pharmaceutical compositions to subjects in need thereof.
US08962616B2 Heterocyclic substituted hexahydropyrano[3,4-d][1,3]thiazin-2-amine compounds
Compounds, tautomers and pharmaceutically acceptable salts of the compounds are disclosed, wherein the compounds have the structure of Formula I, as defined in the specification. Corresponding pharmaceutical compositions, methods of treatment, methods of synthesis, and intermediates are also disclosed.
US08962615B2 Cell migration modulating compounds
The described invention relates to compounds (I) which modulate cell migration, and find use in, for example, wound healing, cancer progression and angiogenesis. All definitions as in claim 1.
US08962614B2 ON01910.Na enhances chemotherapeutic agent activity in drug-resistant tumors
The invention includes compositions and methods of treatment of cancers susceptible to treatment with nucleotide analog chemotherapeutic agent, including cancers in which nucleotide analog resistant tumors have developed, including identifying a subject having cancer susceptible to treatment with a nucleotide analog chemotherapeutic agent and a mitotic disruptor/polo-like kinase (Plk) pathway inhibitor to a subject; and monitoring the subject for a reduction or stabilization of at least one sign or symptom of cancer.
US08962612B2 Tetrahydroisoquinoline derivative
To provide an excellent agent for preventing or treating dementia and schizophrenia based on serotonin 5-HT5A receptor regulating action, it was found that a tetrahydroisoquinoline derivative characterized by a structure in which an acylguanidino group binds to a N atom of a tetrahydroisoquinoline ring or the like, and a cyclic group binds to an unsaturated ring has a potent 5-HT5A receptor regulating action and an excellent pharmacological action based on the regulating action and also discovered that the tetrahydroisoquinoline derivative is useful as an agent for treating or preventing dementia, schizophrenia, and the like, whereby the present invention has been completed.
US08962611B2 Substituted imidazopyridines as HDM2 inhibitors
The present invention provides substituted imidazopyridines as described herein or a pharmaceutically acceptable salt or solvate thereof. The representative compounds are useful as inhibitors of the HDM2 protein. Also disclosed are pharmaceutical compositions comprising the above compounds and potential methods of treating cancer using the same.
US08962610B2 Fused heterocyclic compounds as ion channel modulators
The present disclosure relates to compounds that are sodium channel inhibitors and to their use in the treatment of various disease states, including cardiovascular diseases and diabetes. In particular embodiments, the structure of the compounds is given by Formula I: wherein Y, Z, n, R1 and R3 are as described herein, to methods for the preparation and use of the compounds and to pharmaceutical compositions containing the same.
US08962606B2 Substituted benzosulphonamides
The present invention relates to substituted benzosulphonamide compounds of general formula (I): in which R1, R2, R3, R4, R5 and A are as defined in the claims, to methods of preparing said compounds, to pharmaceutical compositions and combinations comprising said compounds and to the use of said compounds for manufacturing a pharmaceutical composition for the treatment or prophylaxis of a disease, in particular of a hyper-proliferative and/or angiogenesis disorder, as a sole agent or in combination with other active ingredients.
US08962601B2 Pharmaceutical products and composition comprising specific anticholinergic agents, β-2 agonists and corticosteroids
This invention relates to pharmaceutical products and compositions for use in the treatment of asthma and related disorders, and especially but not exclusively for the treatment of chronic obstructive pulmonary disease (COPD). More particularly, the invention provides pharmaceutical products and compositions comprising specific anticholinergic agents, β-2 agonists and corticosteroids.
US08962600B2 Neuroprotective compounds and their use
Apocynin derivative compounds, active pharmaceutical ingredients, dosage forms, and methods of use thereof as neuroprotectants in the brain of mammals.
US08962595B2 Compositions of small molecule therapeutics
Compositions containing a small molecule therapeutic and an alkyl N,N-disubstituted amino acetate are disclosed. Inclusion of the alkyl N,N-disubstituted amino acetate enhances the pharmacokinetic properties of the small molecule therapeutic.
US08962594B2 Method of using nutritional compounds dihydroquercetin (taxifolin) and arabinogalactan in combination with dihydroquercetin (taxifolin) to reduce and control cardiometabolic risk factors associated with metabolic syndrome and hypercholesterolemia
The method of using nutritional compounds including Dihydroquercetin (taxifolin). Arabinogalactan and Arabinogalactan combined with Dihydroquercetin (taxifolin) to reduce and control cardiometabolic risk factors, associated with metabolic syndrome and hypercholesterolemia in a mammal, specifically a human, resulting in the enhancement of metabolism, reduced control levels of cholesterol and triglycerides, reduced oxidative damage in humans and other health benefits.
US08962591B2 Compositions and methods for treating cancer
This invention generally relates to compositions and methods for targeted delivery of chemotherapeutic agents to cancerous and pre-cancerous cells, thereby treating a cancer in a subject.
US08962588B2 Micro-RNAS that control myosin expression and myofiber identity
The present invention relates to the identification of two microRNAs, miR-499 and miR-208b, that repress fast skeletal muscle contractile protein genes. Expression of miR-499 and/or miR-208b can be used to repress fast fiber genes and activate slow fiber genes in the treatment of musculoskeletal disorders. Inhibition of miR-499 and/or miR-208b is proposed as a treatment for cardiac hypertrophy, myocardial infarction, and/or heart failure. Pharmaceutical compositions comprising antagonists and agonists of miR-499 and miR-208b function are also disclosed.
US08962585B2 Treatment of tumor protein 63 (p63) related diseases by inhibition of natural antisense transcript to p63
The present invention relates to antisense oligonucleotides that modulate the expression of and/or function of Tumor Protein 63 (p63), in particular, by targeting natural antisense polynucleotides of Tumor Protein 63 (p63). The invention also relates to the identification of these antisense oligonucleotides and their use in treating diseases and disorders associated with the expression of p63.
US08962579B2 Methods and compositions for inhibition of immune responses and autoimmunity
The application relates to the use of immunoregulatory polynucleotides and/or immunoregulatory compounds in combination with other therapeutic agents. The application further relates to immunoregulatory polynucleotides and/or immunoregulatory compounds comprising a modified immunoregulatory sequence. It also relates to the administration of the immunoregulatory polynucleotides and/or immunoregulatory compounds comprising a modified immunoregulatory sequence to regulate an immune response.
US08962577B2 Controlled release formulations for the delivery of HIF-1 inhibitors
Controlled release dosage formulations for the delivery of one or more HIF-1 inhibitors are provided. The controlled release formulations contain one or more HIF-1 inhibitors conjugated to or dispersed in a polymeric vehicle. The one or more HIF-1 inhibitors can be dispersed or encapsulated in a polymeric matrix. In some embodiments, the one or more HIF-1 inhibitors are covalently bound to a polymer, forming a polymer-drug conjugate. Polymeric vehicles can be formed into implants, microparticles, nanoparticles, or combinations thereof. Controlled release HIF-1 formulations provide prolonged therapeutic benefit while lowering side effects by releasing low levels of one or more HIF-1 inhibitors and/or HIF-1 inhibitor conjugates over a prolonged period of time. Controlled release dosage formulations can be used to treat or prevent a disease or disorder in a patient associated with vascularization, including cancer, obesity, and ocular diseases such as wet AMD.
US08962575B2 Clerodane derivatives for modulation of leukotriene receptor activity and related diseases
The use or methods of use of extracts comprising one or more special clerodane compounds against inflammatory (including allergic) diseases or conditions, as well as novel compounds of this type, said clerodane derivatives for use against inflammatory (including allergic) diseases or conditions, pharmaceutical formulations comprising them especially for use against inflammatory disease or conditions, and related embodiments; said extract and/or compound(s) for use in the treatment or in the preparation of a medicament (including a nutraceutical) for the prophylactic and/or therapeutic treatment of said disease or condition, as well as their preparation; pharmaceutical or nutraceutical formulations comprising said extract and/or natural compound(s) which are useful in said prophylactic and/or therapeutic treatment, and related embodiments.
US08962574B2 Method for treating or preventing thrombosis using dabigatran etexilate or a salt thereof with improved safety profile over conventional warfarin therapy
A method for preventing stroke in a patient suffering from atrial fibrillation, wherein the patient has at least one risk factor for major bleeding events, the method comprising administering to the patient 110 mg b.i.d. of dabigatran etexilate, optionally in the form of a pharmaceutically acceptable salt thereof.
US08962571B2 Method for repairing DNA damage in keratinocytes
A method for repairing DNA damage in human keratinocytes by applying to the keratinocytes a composition comprising at least one CLOCK or PER1 gene activator and at least one DNA repair enzyme.
US08962570B2 Therapeutic use of peptide inhibitors of NADPH oxidase; aerosolization as a delivery mechanism
A method is provided for treatment of a condition mediated by Nox2 in a patient. The method comprises administering to the patient by inhalation a polypeptide as described herein, able to inhibit superoxide production by Nox2. Conditions treatable in this manner include, without limitation, one or more of: right ventricular hypertrophy; pulmonary hypertension; acute lung injury; obstructive sleep apnea; ischemia/reperfusion injury in the lung; pulmonary fibrosis; an obstructive lung disorder such as Chronic Obstructive Pulmonary Disease (COPD), asthma, cystic fibrosis and emphysema; and atherosclerosis.
US08962566B2 Multi-arm polymeric alkanoate conjugates
Among other aspects, provided herein are multi-armed polymer conjugates comprising an alkanoate-linker, compositions comprising such conjugates, and related methods of making and administering the same. Methods of treatment employing such conjugates and related uses are also provided. The conjugates are prepared with high drug loading efficiencies.
US08962565B2 Peptides involved in the SCF c-Kit signaling pathway and compositions comprising same
Peptide compounds of general formula (I) R1-(AA)n-X1—X2—X3-Asp-Leu-Lys-Lys-X4—X5-(AA)p-R2, cosmetic or pharmaceutical compositions comprising at least one peptide compound of general formula (I) in a physiologically acceptable medium, and methods for cosmetic treatment of skin are disclosed. The peptide compounds of general formula (I) were demonstrated to be agents making it possible to influence the pigmentation of the skin and skin appendages, by ensuring optimal transfer of the melanosomes to the keratinocytes, so as to make the skin tone uniform owing to an effect on the SCF/c-Kit signaling pathway. The compounds, compositions, and methods treat or attenuate age-related pigmentation defects and the effects of photoaging on the skin.
US08962564B2 Variant, recombinant beta-glucocerebrosidase proteins with increased stability and increased retained catalytic activity
Described herein are variant, recombinant β-glucocerebrosidase proteins characterized as having increased stability relative to recombinant wild-type β-glucocerebrosidase. Also provided herein are variant, recombinant β-glucocerebrosidase proteins characterized as retaining more catalytic activity relative to recombinant wild-type β-glucocerebrosidase. Further described herein are variant, recombinant β-glucocerebrosidase proteins that can have amino acid variations at one or more of the following positions: 316, 317, 321 and 145. Methods of making the variant, recombinant β-glucocerebrosidase proteins are also described as well as methods of treating patients having lysosomal storage diseases.
US08962563B2 TFPI inhibitors and methods of use
The invention provides peptides that bind Tissue Factor Pathway Inhibitor (TFPI), including TFPI-inhibitory peptides, and compositions thereof. Peptide complexes also are provided. The peptides may be used to inhibit a TFPI, enhance thrombin formation in a clotting factor-deficient subject, increase blood clot formation in a subject, treat a blood coagulation disorder in a subject, purify TFPI, and identify a TFPI-binding compound.
US08962560B2 Innovative discovery of therapeutic, diagnostic, and antibody compositions related to protein fragments of Lysyl-tRNA synthetases
Provided are compositions comprising newly identified protein fragments of aminoacyl-tRNA synthetases, polynucleotides that encode them and complements thereof, related agents, and methods of use thereof in diagnostic, drug discovery, research, and therapeutic applications.
US08962558B2 Methods for reducing GnRH-positive tumor cell proliferation using the GnRH antagonist IN3
A method for recognizing and evaluating the presence and function of GnRH receptors on tumor cells including those originating in the brain and/or nervous system and/or the meninges and/or reactive neuroglia cells and/or primitive neuroectodermal tumor cells and/or on Kaposi sarcoma is provided. Furthermore, a method for reducing degenerate GnRH-positive tumor cells and/or for decreasing cellular replication of the above GnRH-positive tumor cells comprising administering to a cell or to a subject a replication decreasing amount of a GnRH agonist and/or GnRH antagonist and/or an erythropoietin agonist, and/or a thrombopoietin agonist, and/or a endothelin antagonist and/or a gonadotropin inhibiting hormone agonist is also provided. Furthermore, a diagnostic kit for detecting GnRH receptors on tumor cells according to the present methods is disclosed.
US08962557B2 Fibroblast growth factor mutants having improved functional half-life and methods of their use
Mutant fibroblast growth factor (FGF) proteins having a polypeptide sequence with a high sequence identity to proteins encoded by members of the Fgf-1 subfamily of genes from a mammalian species, such as human, and with a specific amino acid substitution of an alanine at a position corresponding to amino acid position 66 of human FGF-1 with a cysteine and/or a specific amino acid substitution of a phenylalanine at a position corresponding to amino acid position 132 of human FGF-1 with a tryptophan (based on the 140 amino acid numbering scheme of human FGF-1) are provided. Other amino acid mutations or substitutions may be combined. Polynucleotide sequences encoding the mutant FGF proteins and host cells containing such polynucleotide sequences are provided. Methods of administering a mutant FGF protein to an individual to treat an ischemic condition or disease or a wound or tissue injury are also provided.
US08962555B2 PlGF-1 in homodimeric form
The present invention relates to a new homodimeric form of recombinant PlGF-1, to a process for its preparation and to compositions containing it.
US08962554B2 Oral insulin therapies and protocol
Methods for treating impaired glucose tolerance and early and late stage diabetes in mammals, for prophylactically sparing β-cell function, aiding in preventing β-cell death, preventing the onset of overt diabetes in a mammal with type 2 diabetes, treating the current level of glycemic control dysfunction of a mammal with impaired glucose tolerance or diabetes, comprising orally administering insulin and a delivery agent that facilitates insulin absorption from the gastrointestinal tract at the time of or shortly before mealtime, e.g., within about 10 minutes prior to ingestion of a meal, on a chronic basis. The methods also comprise, in addition to administering a rapid-acting insulin to provide a first insulin peak, administering a slow acting insulin to provide a second insulin peak occurring at a later time but of a longer duration. These methods achieve improved glycemic control without the risks of hypoglycemia, hyperinsulinemia and weight gain and the need for frequent blood glucose monitoring that are normally associated with insulin therapy.
US08962552B2 Nanoparticles of therapeutic agents having low water solubility
The invention relates to a water-dispersible derivative of a therapeutic agent having a low water solubility that comprises at least one molecule of said agent covalently bonded to at least one molecule of a hydrocarbon derivative having a squalenic structure or the like. The invention further relates to corresponding nanoparticles.
US08962547B2 Compositions comprising enzyme-cleavable oxycodone prodrug
The embodiments provide Compound KC-8, N-1-[3-(oxycodone-6-enol-carbonyl-methyl-amino)-2,2-dimethyl-propylamine]-arginine-glycine-malonic acid, or acceptable salts, solvates, and hydrates thereof. The present disclosure also provides compositions, and their methods of use, where the compositions comprise a prodrug, Compound KC-8, that provides controlled release of oxycodone. Such compositions can optionally provide a trypsin inhibitor that interacts with the enzyme that mediates the controlled release of oxycodone from the prodrug so as to attenuate enzymatic cleavage of the prodrug.
US08962542B2 Process and apparatus for manufacturing grease
A process and corresponding apparatus and system for use in preparing soaps from fatty acid containing oil compositions, and in turn, for preparing greases by the use of such soaps in combination with one or more base oils.
US08962541B2 Processes relating to alcohols for the production of esters
The present invention relates to alcohols and in particular to C4 to C15 alcohols that are used in the production of esters.
US08962540B2 Lubricating oil composition
To provide a lubricating oil composition including a base oil which is composed of a mineral oil and/or a synthetic oil and which has a viscosity index of 95 or higher, and (A) an alkenylsuccinimide in an amount of 0.1 to 2.0 mass %, (B) an acidic phosphite diester having a C6 to C10 hydrocarbon group in an amount of 0.1 to 2.0 mass %, and (C) at least one species selected from among a perbasic alkaline earth metal sulfonate, a perbasic alkaline earth metal phenate, and a perbasic alkaline earth metal salycilate, in an amount of 0.001 to 0.3 mass %, with respect to the total amount of the composition. When employed in an automobile shock absorber, the composition enhances the frictional force at an interface between an oil seal and a piston rod of an automobile shock absorber, reduces the friction coefficient at an interface between a piston rod and a guide bush, suppresses foaming to thereby enhance driving stability during travel of the automobile, and improves riding comfort even when the automobile travels while receiving a lateral load exerted by small steps present on the road surface.
US08962539B2 Friction modifiers for slideway applications
A slideway lubricating oil composition, additive concentrate, method of lubricating sliding parts. The lubricating oil includes a base oil; a metal-free friction modifier; and a metal-free, sulfur-free, phosphorus containing anti-wear/extreme pressure agent. The lubricating oil provides a lower coefficient of friction for non-metal sliding surfaces than for metal sliding surfaces.
US08962538B2 DI forming water-based collant of laminated metal sheet and method for DI forming laminated metal sheet
A DI forming water-based coolant of a laminated metal sheet includes at least one kind of base (a) selected from alkanolamines and alkali metal hydroxides, a fatty acid (b), and water (c), wherein the total content of the base (a) and the fatty acid (b) is 0.02 to 4% by mass and the ratio of a straight-chain fatty acid having a carbon number of 6 to 12 in the fatty acid (b) is 80 to 100% by mass.
US08962535B2 Methods of diverting chelating agents in subterranean treatments
Methods and compositions including a method comprising: providing a treatment fluid comprising an aqueous fluid, a relative permeability modifier, and a chelating agent; introducing the treatment fluid into a well bore that penetrates a subterranean formation; and allowing at least a first portion of the treatment fluid to penetrate into a portion of the subterranean formation so as to substantially divert a second portion of the treatment fluid to another portion of the subterranean formation.
US08962532B2 Programmable iterated elongation: a method for manufacturing synthetic genes and combinatorial DNA and protein libraries
A method for manufacturing synthetic genes and combinatorial DNA and protein libraries, termed here Divide and Conquer-DNA synthesis (D&C-DNA synthesis) method. The method can be used in a systematic and automated way to synthesize any long DNA molecule and, more generally, any combinatorial molecular library having the mathematical property of being a regular set of strings. The D&C-DNA synthesis method is an algorithm design paradigm that works by recursively breaking down a problem into two or more sub-problems of the same type. The division of long DNA sequences is done in silico. The assembly of the sequence is done in vitro. The D&C-DNA synthesis method protocol consists of a tree, in which each node represents an intermediate sequence. The internal nodes are created in elongation reactions from their daughter nodes, and the leaves are synthesized directly. After each elongation only one DNA strand passes to the next level in the tree until receiving the final product. Optionally and preferably, error correction is performed to correct any errors which may have occurred during the synthetic process.
US08962528B2 Penoxsulam as an herbicide in alfalfa
This invention concerns the use of penoxsulam as an herbicide in alfalfa.
US08962527B2 Process for preparation of herbicidal salts
A process for the preparation of solid amine salts of aromatic substituted carboxylic acid herbicides by reaction of the aromatic substituted carboxylic acid herbicide with an amine comprising reacting the aromatic substituted carboxylic acid herbicide in an ether solvent with an amine to form the amine salt and collecting the amine salt of the aromatic substituted carboxylic acid herbicide as a precipitate from the ether solvent reaction mixture wherein the ether is a dialiphatic ether comprising at least one primary aliphatic group.
US08962524B2 Pesticidal mixtures
The present invention relates to a mixture comprising [(3S,4R,4aR,6S,12R,12aS,12bS)-3-(cyclopropanecarbonyloxy)-6,12-dihydroxy-4,6a,12b-trimethyl-11-oxo-9-(pyridin-3-yl)-1,2,3,4,4a,5,6,6a,12a,12b-decahydro-11H,12H-benzo[f]pyrano[4,3-b]chromen-4-yl]methyl cyclopropanecarboxylate and a fungicidal compound II in synergistic effective amounts, to the use of this mixture for controlling pests and for improving the plant health and to plant propagation material comprising this mixture.
US08962523B2 Herbicide/safener combination
A composition comprising(A) one or more compounds of the formula (I) or salts thereof, in which the individual indices have the meaning defined in the description and (B) one or more safeners is described.
US08962522B2 Thermochromic color-memory composition and thermochromic color-memory microcapsule pigment encapsulating the same
The present invention relates to a thermochromic color-memory composition containing: (I) an electron donating coloring organic compound, (II) an electron accepting compound, and (III) an ester compound represented by the following formula (1) as a reaction medium which controls color reaction of the components (I) and (II): (in the formula, X represents any of a hydrogen atom, an alkyl group having 1 to 4 carbon atoms, an alkoxy group having 1 to 4 carbon atoms, and a halogen atom, m represents an integer of from 1 to 3, and n represents an integer of from 1 to 20).
US08962519B2 Precipitated silicic acids for support applications
The present invention relates to novel precipitated silicic acids for use as support materials, manufacture thereof and use thereof.
US08962515B2 Catalyst for producing acrylic acids and acrylates
In one embodiment, the invention is to a process for producing an acrylate product. The process includes the steps of contacting an alkanoic acid and an alkylenating agent over a catalyst composition under conditions effective to produce the acrylate product. The catalyst composition comprises a metal phosphate matrix containing vanadium and bismuth. Preferably, the catalyst comprises, in an active phase, vanadium to bismuth at a molar ratio of at least 0.02:1. Preferably, the catalyst composition is substantially free of titanium.
US08962509B2 Preparation of a solid catalyst system
Process for the preparation of a solid catalyst system (CS) comprising the steps of preparing a liquid clathrate (LC) comprising (a) a lattice (L) being the reaction product of (i) aluminoxane (A), (ii) an organometallic compound (O) of a transition metal (M) of Group 3 to 10 of the Periodic Table (IUPAC 2007) or of an actinide or lanthanide, and (i) a compound (B) being effective to form with the aluminoxane (A) and the organometallic compound (O) the lattice (L), and (b) a guest (G) being an hydrocarbon compound (HC), and subsequently precipitating said liquid clathrate (LC) obtaining said solid catalyst system (SC).
US08962508B2 Process for treating shaped catalyst bodies and shaped catalyst bodies having increased mechanical strength
The present invention provides a process for treating shaped catalyst bodies which has the following steps: a) providing finished shaped catalyst bodies, b) impregnating the finished shaped catalyst bodies with a peptizing auxiliary in an amount of liquid which does not exceed the theoretical water absorption of the shaped catalyst bodies, c) thermal treating the impregnated shaped catalyst bodies at from 50° C. to 250° C. and d) calcinating the thermally treated shaped catalyst bodies at from 250° C. to 600° C. A shaped catalyst body which has increased mechanical strength and can be produced by the process of the invention is also provided. The present invention relates to the use of the shaped catalyst bodies of the invention for preparing amines and also in fixed-bed reactors or fluidized-bed reactors and to a chemical synthesis process in the presence of shaped catalyst bodies according to the present invention.
US08962507B2 Product and process
The invention relates to a composition, which comprises a particulate mixture of: (i) 25 to 80% calcined clay; (ii) 5 to 70% fluxing component; and (iii) 5 to 70% filler component.
US08962505B2 Sintered cubic boron nitride compact and sintered cubic boron nitride compact tool
It is an object of the present invention to provide a sintered cBN compact having excellent wear resistance and fracture resistance even in machining centrifugally cast iron having a property of being difficult to machine, and to provide a sintered cBN compact tool. A sintered cBN compact of the present invention contains 20% by volume or more and 65% by volume or less of cBN and, as a binder, 34% by volume or more and less than 80% by volume of Al2O3, at least one selected from the group consisting of nitrides, carbides, carbonitrides, borides, and boronitrides of Zr and solid solutions thereof (hereinafter, referred to as “X”), and ZrO2, the total amount of X and ZrO2 being 1.0% by volume or more and 6.0% by volume or less, the volume ratio of ZrO2 to Al2O3, ZrO2/Al2O3, being 0.010 or more and less than 0.100, in which the ratio Itetragonal ZrO2(101)/IαAl2O3(110) is 0.1 or more and 3 or less, where Itetragonal ZrO2(101) is the intensity of the (101) plane of tetragonal ZrO2 and IαAl2O3(110) is the intensity of the (110) plane of αAl2O3 among X-ray diffraction peaks of the sintered cBN compact.
US08962502B2 Alkali-free glass and preparation thereof
The present invention provides the composition of an alkali-free glass composition containing no alkali metal oxide and the preparation thereof. The alkali-free glass comprising substantially no alkali metal oxide according to the present invention comprises 61 to 73 wt % of SiO2; 0.5 to 3.9 wt % of B2O3; 3.5 to 13.5 wt % of Al2O3; 9 to 13 wt % of MgO; 1 to 8 wt % of CaO; and 4 to 10 wt % of SrO, based on the total weight of oxides present therein.
US08962501B2 Nonwovens and articles containing submicron fibers
Nonwoven web products containing sub-micron fibers, and more specifically nonwoven web products having sub-micron fibers formed by fibrillation of polymer films, and nonwoven materials and articles incorporating them, and methods of producing these products.
US08962497B2 Fire resistant component
The invention relates to a fire-resistant component (1) which satisfies the requirements of at least class B-15. Such components are known per se and are manufactured as insulated steel structures. In order that the component (1) can be manufactured more easily and with greater versatility in the manner of glass-fiber-reinforced plastic, it is proposed that it is manufactured with multiple layers of phosphate ceramic and also of fibers (7, 8, 9), and that a layer structure of the component (1) comprises at least one layer (4), on the surface thereof which faces towards a potential heat source, which is joined together only partially with a layer (5) arranged thereunder, i.e. remote from the heat source. The invention also relates to a process for producing such a component.
US08962495B2 Film deposition method
A film deposition method includes a first step and a second step. In the first step, a first reaction gas is supplied from a first gas supply part to a first process area, and a second reaction gas capable of reacting with the first reaction gas is supplied from a second gas supply part to a second process area, while rotating a turntable and supplying a separation gas to separate the first process area and the second process area from each other. In the second step, the second reaction gas is supplied from the second gas supply part to the second process area without supplying the first reaction gas from the first gas supply part for a predetermined period, while rotating the turntable and supplying the separation gas to separate the first process area and the second process area from each other.
US08962494B2 Method of manufacturing dual gate oxide devices
The present invention provides method of manufacturing dual gate oxide devices. The method comprises coating photoresist on the substrate which is deposited by an oxide thin film; removing some of the photoresist by exposure and development to divide the oxide thin film into a first area to be etched and a second area coated by the remained photoresist; coating RELACS material on the remained photoresist and heating to form a protective film based on the crosslinking reaction between the RELACS material and the high molecular compounds in the photoresist; performing UV radiation to strengthen and cure the protective film; removing the oxide thin film in the first area by etching and removing the remained photoresist; and depositing again an oxide firm to form an oxide layer of different thickness in the first area and the second area so as to form a dual gate oxide structure.
US08962493B2 Magnetic random access memory cells having improved size and shape characteristics
A manufacturing method to form a memory device includes: (1) forming a dielectric layer adjacent to a magnetic stack; (2) forming an opening in the dielectric layer; (3) applying a hard mask material adjacent to the dielectric layer to form a pillar disposed in the opening of the dielectric layer; and (4) using the pillar as a hard mask, patterning the magnetic stack to form a MRAM cell.
US08962490B1 Method for fabricating semiconductor device
A method for fabricating semiconductor device is disclosed. The method includes the steps of: providing a substrate having an interlayer dielectric (ILD) layer thereon, wherein at least one metal gate is formed in the ILD layer and at least one source/drain region is adjacent to two sides of the metal gate; forming a first dielectric layer on the ILD layer; forming a second dielectric layer on the first dielectric layer; performing a first etching process to partially remove the second dielectric layer; utilizing a first cleaning agent for performing a first wet clean process; performing a second etching process to partially remove the first dielectric layer; and utilizing a second cleaning agent for performing a second wet clean process, wherein the first cleaning agent is different from the second cleaning agent.
US08962483B2 Interconnection designs using sidewall image transfer (SIT)
Methodology enabling a generation of an interconnection design utilizing an SIT process is disclosed. Embodiments include: providing a hardmask on a substrate; forming a mandrel layer on the hardmask including: first and second vertical portions extending along a vertical direction and separated by a horizontal distance; and a plurality of horizontal portions extending in a horizontal direction, wherein each of the horizontal portions is positioned between the first and second vertical portions and at a different position along the vertical direction; and forming a spacer layer on outer edges of the mandrel layer.
US08962482B2 Multi-layer interconnect with isolation layer
An integrated circuit interconnect is fabricated by using a mask to form a via in an insulating layer for a conductive plug. After the plug is formed in the via, a thin (e.g., <100 nm) isolation layer is deposited over the resulting structure. An opening is created in the isolation layer by using the same mask at a different radiation exposure level to make the opening more narrow than the underlying plug. A conductive line is then formed which makes electrical contact with the plug through the opening in the isolation layer. By vertically separating and electrically isolating the conductive plug from adjacent conductive lines, the isolation layer advantageously reduces the likelihood of an undesired electrical short occurring between the conductive plug and a nearby conductive line.
US08962480B2 ESD network circuit with a through wafer via structure and a method of manufacture
A method includes forming an ESD active device on a substrate, forming a ground plane on a backside of the substrate and forming at least one through wafer via electrically connected to a negative power supply of the ESD active device and the ground plane to provide a low series resistance path to the substrate.
US08962479B2 Interconnect structures containing nitrided metallic residues
A metal cap is formed on an exposed upper surface of a conductive structure that is embedded within an interconnect dielectric material. During the formation of the metal cap, metallic residues simultaneously form on an exposed upper surface of the interconnect dielectric material. A thermal nitridization process or plasma nitridation process is then performed which partially or completely converts the metallic residues into nitrided metallic residues. During the nitridization process, a surface region of the interconnect dielectric material and a surface region of the metal cap also become nitrided.
US08962472B2 Semiconductor device with self-aligned air gap and method for fabricating the same
A method for fabricating a semiconductor device includes forming a plurality of semiconductor structures over a substrate, forming an interlayer dielectric layer over the semiconductor structures, etching the interlayer dielectric layer, and defining open parts between the semiconductor structures to expose a surface of the substrate, forming sacrificial spacers on sidewalls of the open parts, forming conductive layer patterns in the open parts, and causing the conductive layer patterns and the sacrificial spacers to reach each other, and defining air gaps on the sidewalls of the open parts.
US08962470B2 Method for forming bumps, semiconductor device and method for manufacturing same, substrate processing apparatus, and semiconductor manufacturing apparatus
A semiconductor substrate is secured by suction to a rear face of a supporting face of a substrate supporting table. In this event, the thickness of the semiconductor substrate is made fixed by planarization on the rear face, and the rear face is forcibly brought into a state free from undulation by the suction to the supporting face, so that the rear face becomes a reference face for planarization of a front face. In this state, a tool is used to cut surface layers of Au projections and a resist mask on the front face, thereby planarizing the Au projections and the resist mask so that their surfaces become continuously flat. This can planarize the surfaces of fine bumps formed on the substrate at a low cost and a high speed in place of CMP.
US08962469B2 Methods of stripping resist after metal deposition
In accordance with an embodiment of the present invention, a method of forming a semiconductor device includes forming a seed layer over a dielectric layer and a patterned resist layer over the seed layer. Next, metal lines are formed on regions of the seed layer not covered by the patterned resist layer. The patterned resist layer is removed using a plasma process, which involves using an oxidizing species and a reducing species in the plasma. The reducing species substantially prevents the oxidation of the metal lines and the seed layer during the plasma process.
US08962460B2 Methods of selectively forming metal-doped chalcogenide materials, methods of selectively doping chalcogenide materials, and methods of forming semiconductor device structures including same
Methods of selectively forming a metal-doped chalcogenide material comprise exposing a chalcogenide material to a transition metal solution, and incorporating transition metal of the transition solution into the chalcogenide material without substantially incorporating the transition metal into an adjacent material. The chalcogenide material is not silver selenide. Another method comprises forming a chalcogenide material adjacent to and in contact with an insulative material, exposing the chalcogenide material and the insulative material to a transition metal solution, and diffusing transition metal of the transition metal solution into the chalcogenide material while substantially no transition metal diffuses into the insulative material. A method of doping a chalcogenide material of a memory cell with at least one transition metal without using an etch or chemical mechanical planarization process to remove the transition metal from an insulative material of the memory cell is also disclosed, wherein the chalcogenide material is not silver selenide.
US08962452B2 Semiconductor die singulation apparatus and method
In one embodiment, a method of singulating semiconductor die from a semiconductor wafer includes forming a material on a surface of a semiconductor wafer and reducing a thickness of portions of the material. Preferably, the thickness of the material is reduced near where singulation openings are to be formed in the semiconductor wafer.
US08962440B2 Semiconductor device and method of manufacturing semiconductor device
A semiconductor device including a semiconductor element; a pad electrode that is formed on the semiconductor element; an alignment mark that is formed on the semiconductor element; a connection electrode that is formed on the pad electrode; and an underfill resin that is formed to cover the connection electrode. The height of the alignment mark from the semiconductor element is greater than that of the connection electrode.
US08962438B2 Variable resistance memory device and method of forming the same
Provided are a variable resistance memory device and a method of forming the same. The variable resistance memory device may include a substrate, a plurality of bottom electrodes on the substrate, and a first interlayer insulating layer including a trench formed therein. The trench exposes the bottom electrodes and extends in a first direction. The variable resistance memory device further includes a top electrode provided on the first interlayer insulating layer and extending in a second direction crossing the first direction and a plurality of variable resistance patterns provided in the trench and having sidewalls aligned with a sidewall of the top electrode.
US08962435B2 Method of forming semiconductor device having embedded strain-inducing pattern
A semiconductor device can include an active region having a fin portion providing a channel region between opposing source and drain regions. A gate electrode can cross over the channel region between the opposing source and drain regions and first and second strain inducing structures can be on opposing sides of the gate electrode and can be configured to induce strain on the channel region, where each of the first and second strain inducing structures including a respective facing side having a pair of {111} crystallographically oriented facets.
US08962434B2 Field effect transistors with varying threshold voltages
A method including providing a semiconductor substrate including a first semiconductor device and a second semiconductor device, the first and second semiconductor devices including dummy spacers, dummy gates, and extension regions; protecting the second semiconductor device with a mask; removing the dummy spacers from the first semiconductor device; and depositing in-situ doped epitaxial regions on top of the extension regions of the first semiconductor device.
US08962431B2 Methods of forming metal silicide-comprising material and methods of forming metal silicide-comprising contacts
A method of forming metal silicide-comprising material includes forming a substrate which includes a first stack having second metal over first metal over silicon and a second stack having second metal over silicon. The first and second metals are of different compositions. The substrate is subjected to conditions which react the second metal with the silicon in the second stack to form metal silicide-comprising material from the second stack. The first metal between the second metal and the silicon in the first stack precludes formation of a silicide comprising the second metal and silicon from the first stack. After forming the metal silicide-comprising material, the first metal, the second metal and the metal silicide-comprising material are subjected to an etching chemistry that etches at least some remaining of the first and second metals from the substrate selectively relative to the metal silicide-comprising material.
US08962428B2 Method of manufacturing a semiconductor device
A semiconductor device and method of fabricating the semiconductor device are disclosed. The method includes forming a plurality of gates on a surface of a substrate, forming sidewalls on side surfaces of the gates, forming a Sigma-shaped recess in the substrate between adjacent gates, forming a SiGe seed layer on an inner surface of the Sigma-shaped recess, forming bulk SiGe doped with boron on a surface of the SiGe seed layer, and filling the Sigma-shaped recess with the boron-doped bulk SiGe, forming a first recess by etching a portion of the SiGe seed layer and the boron-doped bulk SiGe in the Sigma-shaped recess, and forming a SiGe regeneration layer in the first recess beneath the surface of the substrate, wherein the SiGe regeneration layer is doped with boron, and the boron-doped SiGe regeneration layer has a higher concentration of boron than the SiGe seed layer or the boron-doped bulk SiGe.
US08962423B2 Multilayer MIM capacitor
An improved semiconductor capacitor and method of fabrication is disclosed. A MIM stack, comprising alternating first-type and second-type metal layers (each separated by dielectric) is formed in a deep cavity. The entire stack can be planarized, and then patterned to expose a first area, and selectively etched to recess all first metal layers within the first area. A second selective etch is performed to recess all second metal layers within a second area. The etched recesses can be backfilled with dielectric. Separate electrodes can be formed; a first electrode formed in said first area and contacting all of said second-type metal layers and none of said first-type metal layers, and a second electrode formed in said second area and contacting all of said first-type metal layers and none of said second-type metal layers.
US08962421B2 Methods for fabricating integrated circuits including semiconductive resistor structures in a FinFET architecture
A method for fabricating a FinFET integrated circuit includes depositing a first polysilicon layer at a first end of a diffusion region and a second polysilicon layer at a second end of the diffusion region; diffusing an n-type material into the diffusion region to form a diffused resistor; and epitaxially growing a silicon material between the first and second polysilicon layers to form fins structures over the diffused resistor and spanning between the first and second polysilicon layers.
US08962419B2 Complementary stress memorization technique layer method
A process of forming a CMOS integrated circuit by forming a first stressor layer over two MOS transistors of opposite polarity, removing a portion of the first stressor layer from the first transistor, and forming a second stressor layer over the two transistors. A source/drain anneal is performed, crystallizing amorphous regions of silicon in the gates of the two transistors, and subsequently removing the stressor layers. A process of forming a CMOS integrated circuit by forming two transistors of opposite polarity, forming a two stressor layers over the transistors, annealing the integrated circuit, removing the stressor layers, and siliciding the transistors. A process of forming a CMOS integrated circuit with an NMOS transistor and a PMOS transistor using a stress memorization technique, by removing the stressor layers with wet etch processes.
US08962417B2 Method and structure for pFET junction profile with SiGe channel
A semiconductor structure including a p-channel field effect transistor (pFET) device located on a surface of a silicon germanium (SiGe) channel is provided in which the junction profile of the source/drain region is abrupt. The abrupt source/drain junctions for pFET devices are provided by forming an N- or C-doped Si layer directly beneath a SiGe channel layer which is located above a Si substrate. A structure is provided in which the N- or C-doped Si layer (sandwiched between the SiGe channel layer and the Si substrate) has approximately the same diffusion rate for a p-type dopant as the overlying SiGe channel layer. Since the N- or C-doped Si layer and the overlying SiGe channel layer have substantially the same diffusivity for a p-type dopant and because the N- or C-doped Si layer retards diffusion of the p-type dopant into the underlying Si substrate, abrupt source/drain junctions can be formed.
US08962416B1 Split gate non-volatile memory cell
A method of making a semiconductor structure uses a substrate having a background doping of a first type. A gate structure has a gate dielectric on the substrate and a select gate layer on the gate dielectric. Implanting is performed into a first portion of the substrate adjacent to a first end with dopants of a second type. The implanting is prior to any dopants being implanted into the background doping of the first portion which becomes a first doped region of the second type. An NVM gate structure has a select gate, a storage layer having a first portion over the first doped region, and a control gate over the storage layer. Implanting at a non-vertical angle with dopants of the first type forms a deep doped region under the select gate. Implanting with dopants of the second type forms a source/drain extension.
US08962414B1 Reduced spacer thickness in semiconductor device fabrication
In aspects of the present disclosure, a reliable encapsulation of a gate dielectric is provided at very early stages during fabrication. In other aspects, a semiconductor device is provided wherein a reliable encapsulation of a gate dielectric material is maintained, the reliable encapsulation being present at early stages during fabrication. In embodiments, a semiconductor device having a plurality of gate structures is provided over a surface of a semiconductor substrate. Sidewall spacers are formed over the surface and adjacent to each of the plurality of gate structures, wherein the sidewall spacers cover sidewall surfaces of each of the plurality of gate structures. After performing an implantation sequence into the sidewall spacers using adjacent gate structures as implantations masks, shadowing lower portions of the sidewall spacers, an etching process is performed for removing implanted portions from the sidewall spacers, leaving lower shadowed portions of the sidewall spacer as shaped sidewall spacers.
US08962408B2 Replacement gate self-aligned carbon nanostructure transistor
A self-aligned carbon nanostructure transistor is formed by a method that includes providing a material stack including a gate dielectric material having a dielectric constant of greater than silicon oxide and a sacrificial gate material. Next, a carbon nanostructure is formed on an exposed surface of the gate dielectric material. After forming the carbon nanostructure, metal semiconductor alloy portions are formed self-aligned to the material stack. The sacrificial gate material is then replaced with a conductive metal.
US08962407B2 Method and device to achieve self-stop and precise gate height
A method for enabling fabrication of RMG devices having a low gate height variation and a substantially planar topography and resulting device are disclosed. Embodiments include: providing on a substrate two dummy gate electrodes, each between a pair of spacers; providing a source/drain region between the two dummy gate electrodes; and forming a first nitride layer over the two dummy gate electrodes and the source/drain region, wherein the first nitride layer comprises a first portion over the dummy gate electrodes and a second portion over the source/drain region, and the second portion has an upper surface substantially coplanar with an upper surface of the dummy gate electrodes.
US08962405B2 Method of manufacturing semiconductor device by mounting and positioning a semiconductor die using detection marks
In some aspects of the invention, a circuit pattern of a front surface structure is formed in a front surface of a semiconductor wafer and an alignment mark is formed on the front surface of a semiconductor wafer. A transparent supporting substrate is attached to the front surface of the semiconductor wafer by a transparent adhesive. Then, a resist is applied onto a rear surface of the semiconductor wafer. Then, the semiconductor wafer is mounted on a stage of an exposure apparatus, with the supporting substrate down. Then, the alignment mark formed on the front surface of the semiconductor wafer is recognized by a camera, and the positions of the semiconductor wafer and a photomask are aligned with each other. Then, the resist is patterned. Then, a circuit pattern is formed in the rear surface of the semiconductor wafer.
US08962401B2 Double gated 4F2 dram CHC cell and methods of fabricating the same
A semiconductor device is provided that includes a fin having a first gate and a second gate formed on a first sidewall of the fin in a first trench, wherein the first gate is formed above the second gate. The device includes a third gate and a fourth gate formed on a second sidewall of the fin in a second trench, wherein the third gate is formed above the fourth gate. Methods of manufacturing and operating the device are also included. A method of operation may include biasing the first gate and the fourth gate to create a current path across the fin.
US08962397B2 Multiple well drain engineering for HV MOS devices
At least one N-well implant having a different doping level is formed in a silicon substrate by first etching the substrate with an alignment target for aligning future process masks thereto. This alignment target is outside of any active device area. By using at least one N-well implant having a different doping level in combination with the substrate, a graded junction in the drift area of a metal oxide semiconductor (MOS) field effect transistor (FET) can be created and a pseudo Ldd structure may be realized thereby.
US08962394B2 Semiconductor device and method of manufacturing the same
A semiconductor device includes a substrate, a semiconductor element disposed on the substrate, and a heat conductive member composed of a solder material. The heat conductive member covers the semiconductor element, and is connected to a connection pad formed on the substrate. A heat radiator is disposed on the heat conductive member. The heat conductive member thermally connecting the semiconductor element to the heat radiator reduces the risk that electromagnetic noise may be emitted from or may be incident on the semiconductor element.
US08962393B2 Integrated circuit packaging system with heat shield and method of manufacture thereof
A method of manufacture of an integrated circuit packaging system includes: mounting a device mounting structure over a bottom substrate; mounting a heat spreader having an opening formed by a single integral structure with a dam and a flange, the dam having a dam height greater than a flange height of the flange; and forming a package encapsulation over the device mounting structure and the bottom substrate with the device mounting structure exposed within the opening.
US08962392B2 Underfill curing method using carrier
A method includes bonding a carrier over a top die. The method further includes curing an underfill disposed between a substrate and the top die. The method further includes applying a force over the carrier during the curing. The method further includes removing the carrier from the top die.
US08962391B2 Method of fabricating a wafer level chip scale package without an encapsulated via
An improved wafer level chip scale packaging technique is described which does not use an encapsulated via to connect between a redirection layer and a pad within the pad ring on the semiconductor die. In an embodiment, a first dielectric layer is formed such that it terminates on each die within the die's pad ring. Tracks are then formed in a conductive layer which contact one of the pads and run over the edge of an opening onto the surface of the first dielectric layer. These tracks may be used to form an electrical connection between the pad and a solder ball.
US08962387B2 Methods of forming memory cells
Some embodiments include methods of forming memory cells in which a metal oxide material is formed over a first electrode material, an oxygen-sink material is formed over and directly against the metal oxide material, and a second electrode material is formed over the oxygen-sink material. The second electrode material is of a different composition than the oxygen-sink material. The metal oxide material is treated to transfer oxygen from a region of the metal oxide material to the oxygen-sink material and thereby subdivide the metal oxide material into at least two regions, with one of the regions nearest the oxygen-sink material being relatively oxygen depleted relative to another of the regions.
US08962384B2 Memory cells having heaters with angled sidewalls
Memory cells having heaters with angled sidewalls and methods of forming the same are described herein. As an example, a method of forming an array of resistive memory cells can include forming a first resistive memory cell having a first heater element angled with respect to a vertical plane, forming a second resistive memory cell adjacent to the first resistive memory cell and having a second heater element angled with respect to the vertical plane and toward the first heater, and forming a third resistive memory cell adjacent to the first resistive memory cell and having a third heater element angled with respect to the vertical plane and away from the first heater element.
US08962383B2 Multi-nozzle organic vapor jet printing
Systems and methods are provided for depositing thin patterned films of materials in which individual elements of the patterned film are deposited by two or more nozzles having different geometries. The different nozzle geometries may include one or more of different throttle diameters, different exhaust diameters, different cross-sectional shapes, different bore angles, different wall angles, different exhaust distances from the substrate, and different leading edges relative to the direction of movement of the nozzles or the substrate. Methods may include steps of ejecting a carrier gas and a material from a plurality of nozzles and depositing the material on a substrate in a plurality of laterally spaced elements.
US08962382B2 Fabrication method for organic light emitting device and organic light emitting device fabricated by the same method
The present invention relates to a method for producing an organic light emitting device, comprising a step of sequentially forming on a substrate a first electrode formed of a metal, one or more organic material layers including a light emitting layer, and a second electrode, which comprises a step of forming a layer on the first electrode using a metal having the higher oxidation rate than the first electrode before forming the organic material layer, and to an organic light emitting device produced by the same.
US08962381B2 Method for manufacturing a solar cell and a solar cell manufactured according to this method
A method for manufacturing a solar cell from a p-doped or n-doped silicon substrate having a first main surface used as an incident-light side and a second main surface used as a back side includes: depositing a thin layer onto the second main surface; depositing a dielectric, glass-forming paste onto the second main surface and drying it, in order to cover the thin layer; heating and/or sintering the paste on the second main surface at temperatures greater than app. 577° C., to produce an aluminum dopant layer in the second main surface; and removing the glass layer formed during the heating and/or sintering, as well as an aluminum-silicon eutectic layer formed during the heating and/or sintering, from the second main surface.
US08962376B2 Optoelectronic device with lateral pin or pin junction
An optoelectronic device, including a semiconductor body having a surface to receive photons and a plurality of doped regions of opposite doping polarities, the doped regions extending substantially from the surface of the semiconductor body and into the semiconductor body, and being arranged in one or more pairs of opposite doping polarities such that each pair of doped regions forms a corresponding space charge region having a corresponding electric field therein, the space charge region extending substantially from the surface of the semiconductor body and into the semiconductor body such that photons entering the semiconductor body through the surface and travelling along paths within the space charge region generate electron-hole pairs in the space charge region that are separated in opposing directions substantially orthogonal to the photon paths by the electric field and collected by the corresponding pair of doped regions, thereby providing an electrical current to be conducted from the device.
US08962374B2 Integration of a titania layer in an anti-reflective coating
A stack of a first anti-reflective coating (ARC) layer and a titanium layer is formed on a front surface of a semiconductor substrate including a p-n junction, and is subsequently patterned so that a semiconductor surface is physically exposed in metal contact regions of the front surface of the semiconductor substrate. The remaining portion of the titanium layer is converted into a titania layer by oxidation. A metal layer is plated on the metal contact regions, and a copper line is subsequently plated on the metal layer or a metal semiconductor alloy derived from the metal layer. A second ARC layer is deposited over the titania layer and the copper line, and is subsequently patterned to provide electrical contact to the copper line.
US08962368B2 CMOS compatible MEMS microphone and method for manufacturing the same
The present invention relates to a CMOS compatible MEMS microphone, comprising: an SOI substrate, wherein a CMOS circuitry is accommodated on its silicon device layer; a microphone diaphragm formed with a part of the silicon device layer, wherein the microphone diaphragm is doped to become conductive; a microphone backplate including CMOS passivation layers with a metal layer sandwiched and a plurality of through holes, provided above the silicon device layer, wherein the plurality of through holes are formed in the portions thereof opposite to the microphone diaphragm, and the metal layer forms an electrode plate of the backplate; a plurality of dimples protruding from the lower surface of the microphone backplate opposite to the diaphragm; and an air gap, provided between the diaphragm and the microphone backplate, wherein a spacer forming a boundary of the air gap is provided outside of the diaphragm or on the edge of the diaphragm.
US08962359B2 Photon extraction from nitride ultraviolet light-emitting devices
In various embodiments, a rigid lens is attached to a light-emitting semiconductor die via a layer of encapsulant having a thickness insufficient to prevent propagation of thermal expansion mismatch-induced strain between the rigid lens and the semiconductor die.
US08962356B2 Method of manufacturing photonic crystal and method of manufacturing surface-emitting laser
Provided is a method of manufacturing a photonic crystal, including: a first step of forming, on a surface of a substrate, a protective mask for selective growth, the protective mask having an opening pattern opened therein; a second step of selectively growing a columnar semiconductor from an exposed portion of the surface of the substrate not having the mask formed thereon, laterally overgrowing the semiconductor layer on the mask, and embedding the mask; a third step of forming a photonic crystal in the semiconductor layer so that openings in the opening pattern and the one of pores and grooves which form the photonic crystal are at least partly overlapped each other when seen from a direction perpendicular to the surface of the substrate; a fourth step of removing at least part of the columnar semiconductor; and a fifth step of removing at least part of the mask.
US08962353B2 System and methods for semiconductor device performance prediction during processing
Methods and systems for predicting semiconductor device performance criteria during processing. A method is described that includes receiving a semiconductor wafer; performing semiconductor processing on the semiconductor wafer forming active devices that, when completed, will exhibit a device performance criteria; during the semiconductor processing, measuring in line at least one device performance criteria related physical parameter; projecting an estimated value for the device performance criteria of the active devices using the at least one in line measurement and using estimated measurements for device performance criteria related physical parameters corresponding to later semiconductor processing steps; comparing the estimated value for the device performance criteria to an acceptable range; and determining, based on the comparing, whether the active devices on the semiconductor wafer will have a device performance criteria within the acceptable range. A system for processing semiconductor wafers that includes a programmable processor for performing the methods is described.
US08962348B2 Co/Ni multilayers with improved out-of-plane anisotropy for magnetic device applications
A method for forming a MTJ in a spintronic device is disclosed and includes a thin seed layer that enhances perpendicular magnetic anisotropy (PMA) in an overlying laminated layer with a (Co/Ni)n composition. The seed layer is preferably NiCr, NiFeCr, Hf, or a composite thereof. Furthermore, a magnetic layer such as CoFeB may be formed between the laminated layer and a tunnel barrier layer to serve as a transitional layer between a (111) laminate and (100) MgO tunnel barrier. There may be a Ta insertion layer between the CoFeB layer and laminated layer to promote (100) crystallization in the CoFeB layer. The laminated layer may be used as a reference layer, dipole layer, or free layer in a MTJ. Annealing between 300° C. and 400° C. may be used to further enhance PMA in the laminated layer.
US08962345B2 Method of characterizing glycans attached to glycoproteins
A method of characterizing glycans attached to glycoproteins is disclosed herein. The method comprises a first step of immobilizing the glycoproteins on colloidal particles forming glycoprotein/colloidal particles. The glycans on the glycoproteins may then be characterized, for example the composition and/or structure of glycans may be characterized or the glycans attached to proteins may be identified. Characterization may be accomplished by either binding the glycoprotein/colloidal particles with one or more binding agents and assessing the aggregation of the glycoprotein/colloidal particles or by cleaving glycans from the glycoprotein/colloidal particles with a cleaving agent and analyzing the glycans.
US08962339B2 Fluorescent probe compounds, preparation method and application thereof
The present invention discloses a fluorescent probe compound which solved the problem of fluorescence quenching by Pd2+, and its preparation method and use as well. Excitation and emission wavelengths of the probe compound are in visible light region. The probe compound is highly sensitive and displays good selectivity for Pd2+ in near-neutral pH range. In detection of Pd2+ in 0-10 ppb level, fluorescence is evidently enhanced, and Pd2+ in the level as low as 5 nM can be detected. Fluorescence intensity is well linearly correlated to Pd2+ concentration. The probe compound can be used for detection of contaminating palladium and residual palladium in drug, soil, water sample and reactor.
US08962338B2 Methods for measurement of calcium ions
Reagents and methods for determination of calcium within a sample. Specific embodiments include a reagent for determination of calcium comprising a mono-nitro substituted BAPTA-type chelator (BAPTA=1,2-bis(2-aminophenoxy)ethane-N,N,N′,N′-tetraacetic acid). Methods for accurate determination of calcium in a sample, such as a blood, whole blood, plasma or serum or any other aqueous liquid sample including cerebrospinal fluid, lymph, salivary juice or urine. Embodiments are also useful for clinical diagnoses.
US08962336B2 Soil diagnosis and improvement method
Disclosed are a soil diagnosis method for diagnosing soil using a cycle activity indicator which is calculated using the following factors (I) to (III): (I) the ammonia reduction rate in target soil; (II) the activity of forming phosphoric acid from phytic acid in the target soil; and (III) the activity of forming potassium from compost in the target soil, and (IV) the soil bacteria count in the soil; and a soil quality control method; and a soil improvement method.
US08962335B2 Gaming machine and control method thereof
The present invention provides a gaming machine executing the processing of (A) displaying on the display at least one playing card in a display mode that displays each playing card face down; and (B) changing the display mode of one of the at least one playing card displayed in the processing (A) to a display mode enabling a part of the front of the playing card to be viewable, upon contact on any position within an area of the touch panel corresponding to an area of the display where the one of the at least one playing card is displayed.
US08962331B2 Method of making induced pluripotent stem cell from adipose stem cells using minicircle DNA vectors
Human somatic cells are reprogrammed to become induced pluripotent stem cells (iPS cells) by the introduction of a minicircle DNA vector. Cells of interest include adipose stem cells.
US08962330B2 Adeno-associated virus (AAV) serotype 8 sequences, vectors containing same, and uses therefor
Sequences of a serotype 8 adeno-associated virus and vectors and host cells containing these sequences are provided. Also described are methods of using such host cells and vectors in production of rAAV particles.
US08962326B2 Methods for producing transgenic plants
A method of producing a stably transformed corn plant in a single container is demonstrated. This method allows for the automation of the transformation process and reduces labor, material, and ergonomic costs associated with traditional plant tissue culture systems.
US08962324B2 Method and system for treatment of biological tissue
A composition for reconstruction, replacement or repair of damaged or diseased biological tissue comprising an extracellular matrix (ECM) composition that includes an ECM scaffold component and a bioactive agent component. In a preferred embodiment, the ECM scaffold component comprises mesothelial tissue and the bioactive agent comprises a statin.
US08962322B2 Enhancers of induced pluripotent stem cell reprogramming
Described herein, inter alia, are methods and compositions useful for induced pluripotent stem cell reprogramming.
US08962321B2 Mesenchymal stromal cells and uses related thereto
The present invention generally relates to novel preparations of mesenchymal stromal cells (MSCs) derived from hemangioblasts, methods for obtaining such MSCs, and methods of treating a pathology using such MSCs. The methods of the present invention produce substantial numbers of MSCs having a potency-retaining youthful phenotype, which are useful in the treatment of pathologies.
US08962320B2 Treating cardiovascular tissue
This document provides methods and materials for treating cardiovascular tissue. For example, stem cells, compositions containing stem cells, methods for obtaining stem cells, compositions for generating stem cells expressing particular markers, and methods for repairing cardiovascular tissue are provided.
US08962318B2 Method of deriving mesenchymal stem cells from ES cells using FGF2
We disclose a method comprising: (a) providing an embryonic stem (ES) cell; and (b) establishing a progenitor cell line from the embryonic stem cell; in which the progenitor cell line is selected based on its ability to self-renew. Preferably, the method selects against somatic cells based on their inability to self-renew. Preferably, the progenitor cell line is derived or established in the absence of co-culture, preferably in the absence of feeder cells, which preferably selects against embryonic stem cells. Optionally, the method comprises (d) deriving a differentiated cell from the progenitor cell line.
US08962317B2 Uses of IL-12 and the IL-12 receptor positive cell in tissue repair and regeneration
The present application relates to stem cells isolated from various sources within the body of a patient or of a healthy donor and identified by the presence of the interleukin 12 (IL-12) receptor. The present application also provides methods for making and for using the stem cells.
US08962307B2 Method and kit for diagnosing autism using gene expression profiling
This invention relates to DNA microarray technology, and more specifically to methods and kits for identifying autism and autism spectrum disorders in humans.
US08962301B2 Biochip and method for manufacturing the same
A biochip and a method for manufacturing the same are provided. The biochip can increase a surface area on which biomaterials can be immobilized and improve efficiency of reaction. The biochip includes: a substrate; a coating layer formed on the substrate; and a nanoparticle immobilized on the substrate by the coating layer, a material to be bound to a target material being attached on a surface of the nanoparticle.
US08962300B2 Reagents and methods for cyanobacterial production of bioplastics and biomaterials
The present invention provides reagents and methods for biomaterial production from cyanobacteria.
US08962297B2 Bacteriophage lytic enzymes as alternative antimicrobials
The present invention relates to isolated Clostridium perfringens bacteriophage lytic enzymes from baccteriophages CP26F and CP39O, and uses in controlling Clostridium perfringens.
US08962296B2 Isoprene synthase and gene encoding the same, and method for producing isoprene monomer
The present invention provides means useful for establishing an excellent isoprene monomer production system. Specifically, the present invention provides a polynucleotide of the following (a), (b), or (c): (a) a polynucleotide comprising (i) the nucleotide sequence represented by SEQ ID NO:1, or (ii) the nucleotide sequence consisting of the nucleotide residues at positions 133 to 1785 in the nucleotide sequence represented by SEQ ID NO:1; (b) a polynucleotide that comprises a nucleotide sequence having 90% or more identity to the nucleotide sequence of (i) or (ii) above, and encodes a protein having an isoprene synthase activity; or (c) a polynucleotide that hybridizes under a stringent condition with a polynucleotide consisting of a nucleotide sequence complementary to the nucleotide sequence of (i) or (ii) above, and encodes a protein having an isoprene synthase activity; and the like.
US08962289B2 Strains of Saccharomyces cerevisiae
A method for producing a strain of Saccharomyces cerevisiae with introduced genes coding for xylose reductase, xylitol dehydrogenase and xylulokinase and with improved ethanol production, improved xylose conversion, reduced xylitol production and improved inhibitor tolerance is described. The method comprises culturing a strain of Saccharomyces cerevisiae at a continuous mode with a medium comprising essentially only xylose as carbon source at a temperature of 25-38° C., preferably 30-35° C., and an airflow of 0.040-0.055 vvm, and increasing the dilution rate to maintain a constant cell level, said cell level being in the range of 1.5-3.0 determined by optical density or equivalent analytical means, and adding at least one inhibitor to the cells and gradually increasing the addition of said inhibitor. Further, strains of Saccharomyces cerevisiae obtained by the method according to the invention are described.
US08962288B2 Methods for producing a fermentation product from cellulosic material in the presence of a peroxidase
A method for production of a fermentation product from cellulosic material where a cellulosic material is saccharified with an enzyme composition in the presence of a peroxide-generating system and a polypeptide having peroxidase activity, the resultant saccharified cellulosic material is fermented and a fermentation product is recovered. Inclusion of the polypeptide having peroxidase activity increases saccharification of the cellulosic material.
US08962286B2 Fermentation processes and by-products
The present disclosure relates to an improved process of producing a fermentation product, in particular ethanol. The present disclosure relates also to the use of enzymes for improving the quality of by-products in the fermentative production process and to compositions comprising enzymes capable of degrading components in the fermented mash in the fermentation process.
US08962281B2 Engineered cleavage half-domains
Disclosed herein are engineered cleavage half-domains; fusion polypeptides comprising these engineered cleavage half-domains; polynucleotides encoding the engineered cleavage half-domains and fusion proteins; and cells comprising said polynucleotides and/or fusion proteins. Also described are methods of using these polypeptides and polynucleotides, for example for targeted cleavage of a genomic sequence.
US08962280B2 Methods for detecting DNA orginating from different individuals
In a first aspect, the present invention features methods for differentiating DNA species originating from different individuals in a biological sample. These methods may be used to differentiate or detect fetal DNA in a maternal sample or to differentiate DNA of an organ donor from DNA of an organ recipient. In preferred embodiments, the DNA species are differentiated by observing epigenetic differences in the DNA species such as differences in DNA methylation. In a second aspect, the present invention features methods of detecting genetic abnormalities in a fetus by detecting fetal DNA in a biological sample obtained from a mother. In a third aspect, the present invention features methods for differentiating DNA species originating from an organ donor from those of an organ recipient. In a fourth aspect, the present invention features kits for differentiating DNA species originating from different individuals in a biological sample.
US08962278B2 Compositions and methods for production of immunoglobulins
Provided are oligonucleotides for isolating human antibody cDNAs from cells or cell lines, such as hybridomas. The invention also provides cDNAs that encode at least one provided CDR of a heavy chain or a light chain of a human monoclonal antibody that binds to B. anthracis protective antigen; and cDNAs that encode at least one provided CDR of a heavy chain or a light chain of a human monoclonal antibody that binds to B. anthracis lethal factor. The invention further provides expression vectors that contain one or more cDNAs isolated according to the methods of the invention, host cells expressing one or more inventive cDNAs, and transgenic plants and animals that express one or more inventive cDNAs. In certain embodiments of the invention the expression system is a plant-based expression system. The invention further provides antibody compositions comprising one or more antibodies produced by expressing a cDNA isolated according to the methods of the invention in a suitable expression system. Additionally encompassed in the invention are kits containing one or more of provided compositions, as well as methods of production and use of provided compositions.
US08962277B2 Production cell line
The invention refers to a method of producing a recombinant polypeptide of interest (POI) in a cell culture, comprising genetically engineering a eukaryotic cell line—to specifically cause prolongation of the G2+M cell cycle phase in a pre-culture phase, and—to produce the POI in a producing phase following the pre-culture phase, a high producer cell line and cell culture as well as a method of increasing the yield of a recombinant POI production in a cell culture.
US08962272B2 Engineered bacteria produce succinate from sucrose
Bacteria optimized to produce succinate and other feedstocks by growing on low cost carbon sources, such as sucrose.
US08962270B2 Electrochemical analyte measurement method and system
Described and illustrated herein are systems and exemplary methods of operating an analyte measurement system having a meter and a test strip. In one embodiment, the method may be achieved by applying a first test voltage between a reference electrode and a second working electrode and applying a second test voltage between the reference electrode and a first working electrode; measuring a first test current, a second test current, a third test current and a fourth test current at the second working electrode after a blood sample containing an analyte is applied to the test strip; measuring a fifth test current at the first working electrode; estimating a hematocrit-corrected analyte concentration from the first, second, third, fourth and fifth test currents; and annunciating the hematocrit-corrected analyte concentration.
US08962267B1 Method for predicting the response of non-small cell lung cancer patients to targeted pharmacotherapy
The present invention relates to a method for determining or predicting the response of a patient diagnosed with non small cell lung cancer to targeted pharmacotherapy. The present invention also aims to provide methods and devices for predicting the response of patients diagnosed with non small cell lung cancer to specific medicaments. More specifically, the present invention provides methods which measure kinase activity by studying phosphorylation levels and profiles and inhibitions thereof by drugs in samples of said patients.
US08962266B2 Methods for assaying enzyme activities
The present invention provides compounds and methods for assaying activities of enzymes such as histone deacetylases and histone acetyltransferases. In some embodiments, the methods may be performed in one step. The compounds described herein features peptide-based compounds having at least one blocked lysine or arginine residue which are coupled to reporter moieties. The methods described herein involve reacting a compound described herein with an enzyme, such as a histone deacetylase enzyme or a histone acetyltransferase enzyme, and an endopeptidase that recognizes basic amino acids to release the reporter moiety which may be subsequently detected.
US08962262B2 Method of protein extraction from cells
Methods for producing a protein extract from cells, such as cells containing viral proteins, are provided. In general terms, the methods involve: increasing the pH of the cells to a pH of at least about pH 10.0 to produce an intermediate composition, and then, in the presence of a non-ionic detergent, neutralizing the pH of the intermediate composition to produce the protein extract. Kits and compositions for practicing the subject methods are also provided.
US08962253B2 Methods and compositions for detection of small RNAs
Currently, the circularization of small RNAs is broadly regarded as an obstacle in ligation-related assays and explicitly avoided while short lengths of linear RNA targets is broadly recognized as a factor limiting use of conventional primers in PCR-related assays. In contrast, the disclosed invention capitalizes on circularization of small RNA targets or their conjugates with oligonucleotide adapters. The circular RNA templates provide amplification of the target sequences via synthesis of multimer nucleic acids that can be either labeled for direct detection or subjected to PCR amplification and detection. Structure of small circular RNAs and corresponding multimeric nucleic acids provide certain advantages over current methods including flexibility in design of conventional RT and PCR primers as well as use of 5′-overlapping dimer-primers for efficient and sequence-specific amplification of short target sequences. Our invention also reduces number of steps and reagents while increasing sensitivity and accuracy of detection of small RNAs with both 2′OH and 2′-OMe at their 3′ ends. Our invention increase sensitivity and specificity of detection of microRNAs and other small RNAs with both 2′OH and 2′-OMe at their 3′ ends while allowing us to distinguish these two forms from each other.
US08962252B2 Optical system for high resolution thermal melt detection
This invention relates to systems and methods for imaging sample materials within a microfluidic device during an assay reaction process. In accordance with certain aspects of the invention, images are formed with a pixel array and a region of interest (“ROI”) is defined within the pixel array. Image values, such as fluorescent intensity, can be computed as averages of individual pixel values within the ROI. Where the ROI is subject to non-uniform conditions, such as non-uniform heating, the ROI can be divided into sub-ROIs which are sufficiently small that the condition is uniform within the sub-ROI.
US08962247B2 Processes and compositions for methylation-based enrichment of fetal nucleic acid from a maternal sample useful for non invasive prenatal diagnoses
Provided are compositions and processes that utilize genomic regions that are differentially methylated between a mother and her fetus to separate, isolate or enrich fetal nucleic acid from a maternal sample. The compositions and processes described herein are particularly useful for non-invasive prenatal diagnostics, including the detection of chromosomal aneuplodies.
US08962245B2 Method for producing circular DNA formed from single-molecule DNA
There is provided a method for producing a circular DNA which consists of a circular DNA formed from a single-molecule DNA and which does not comprise circular DNA formed from multiple-molecule DNA. According to the method of the present invention, a circular DNA molecule formed only from a single-molecule DNA can be reliably produced.
US08962243B2 Post protein hydrolysis removal of a potent ribonuclease inhibitor and the enzymatic capture of DNA
The present invention concerns compositions and methods of extracting infectious pathogens from a volume of blood. In one embodiment, the method includes the steps of creating a fibrin aggregate confining the pathogens and introducing a fibrin lysis reagent to expose the pathogens for analysis. The present invention also concerns materials and methods for removing aurintricarboxylic acid (ATA) from a sample.
US08962238B2 Nucleic acid enzymes and complexes and methods for their use
The present invention relates to methods that utilize multi-component nucleic acid complex (MNA complex) cascades. The MNA complexes may have cleavage or ligase activity. Further, the invention provides cascades which may include one or more DNAzymes. The invention also provides methods which use these cascades for the identification, detection and quantification of targets.
US08962237B2 Method of detecting and identifying circulating antigens in human biological samples
Disclosed herein is a method of detecting and identifying antigens that are shed into human bodily fluids during infection. The disclosed method allows circulating antigens associated with a particular infection to be detected within minutes or hours from testing as compared to days required with the current methods. Methods of identifying diagnostic indicators/targets for a given condition or disease are disclosed which include immunizing a veterinary subject with biological fluids obtained from a human infected with particular antigens to identify diagnostic targets for immunoassay. Also disclosed are methods of diagnosing and monitoring a B. pseudomallei-associated condition, such as melioidosis. Point-of-care immunoassays are also provided that can be used to diagnose or monitor the efficacy of a B. pseudomallei-associated condition treatment. These immunoassays can also be used for rapid diagnosis of infection produced by B. pseudomallei, such as meliodosis.
US08962225B2 Charge transporting film, photoelectric conversion device, electrophotographic photoreceptor, process cartridge, and image forming apparatus
A charge transporting film includes a cured film of a composition containing at least one selected from reactive compounds represented by the following Formula (I): wherein F represents a charge transporting skeleton, D represents a group represented by Formula (IIa), m represents an integer of from 1 to 8, E represents a group represented by Formula (IIb), L represents a (n+1)-valent linking group including two or more selected from the group consisting of an alkylene group, an alkenylene group, —C(═O)—, —N(R)—, —S—, —O—, and a trivalent or tetravalent group derived from alkane or alkene, R represents a hydrogen atom, an alkyl group, an aryl group, or an aralkyl group, n represents an integer of from 1 to 3, R0 represents a halogen atom, an alkyl group, or an alkoxy group, and n0 represents an integer of from 0 to 3.
US08962220B2 Reflective photomask and reflective photomask blank
Provided is a reflective photomask reflecting an EUV light and used to irradiate a reflected light to a transfer sample, the reflective photomask including: a substrate; a high reflection part formed on the substrate; and a low reflection part formed on the high reflection part and being patterned, wherein the low reflection part, being patterned, includes at least one or more layers being stacked; and at least one layer of the low reflection part, being patterned, includes a layer including an Sn and an oxygen.
US08962213B2 Direct catalyst coating on free standing microporous layer
Methods of making reinforced membrane electrode assemblies are described. Catalyst coated free standing microporous layers and reinforced membrane electrode assemblies are also described.
US08962212B2 Unit cell module and gasket for polymer electrolyte fuel cell
A polymer electrolyte fuel cell-use gasket, included in a polymer electrolyte fuel cell including a fuel cell stack is provided. In the fuel cell stack, a plurality of unit cell modules is stacked, and each of the unit cell modules includes sealing members disposed at circumference portions of respective front and back surfaces of a membrane electrode assembly, and paired separators sandwiching the membrane electrode assembly and the sealing members. The sealing members are integrally molded with the circumference portions of the respective front and back surfaces of the membrane electrode assembly. In each sealing member of the gasket, two rows of sealing lips are continuously provided in parallel to each other in an in-plane manner, and at least an outer one of the two rows of sealing lips is integrally formed, having a top side bell-shaped portion overlaid on a bottom side bell-shaped portion.
US08962208B2 Predictive cathode compressor speed control in a fuel cell power system
A method and device for predictively controlling the speed of a compressor used in conjunction with a fuel cell stack. Feedforward command signals are generated based on fuel cell stack setpoints that are based on stack humidification requirements. A pressure drop model uses these setpoints to determine a compressor outlet pressure setpoint change brought about by an operational transient. A recursive approach is used to solve for one or more future or desired compressor operating conditions. The results of this recursive approach are used to determine the feedforward speed command of the compressor, where known operational parameters (such as can be found on a compressor map) may be used. This permits rapid changes in compressor speed to comply with the new operating point of the fuel cell system that is brought about by the operational transient.
US08962206B2 Methods of operating fuel cell stacks and systems related thereto
Methods and systems for operating a fuel cell stack having a fuel exhaust stream and a vessel downstream of the fuel cell stack fluidly connected to the fuel exhaust stream are provided. In one embodiment, the method comprises displacing substantially all residual gas in the vessel by providing at least a portion of the fuel exhaust stream to the vessel, and isolating the vessel from the fuel cell stack after the fuel exhaust stream displaces substantially all residual gas in the vessel. At least one bleed down characteristic is determined as fuel exhaust within the vessel is released through an orifice, and an operating condition of the fuel cell stack is set or determined based on the at least one bleed down characteristic. In a specific embodiment, the hydrogen concentration in the fuel exhaust is determined based on the at least one bleed down characteristic.
US08962205B2 Fuel cell stack
A fuel cell stack includes a stacked body, a first terminal plate, a first insulating plate, a first end plate, and a first insulating collar member. The first insulating collar member includes a first tubular portion and a first flange portion. The first tubular portion is provided in the first fluid manifold hole. The first flange portion is disposed at one end of the first tubular portion. Another end of the first tubular portion projects to an outside of the first fluid manifold hole and is in slidably contact with an inner circumferential surface of the first outer manifold member via an outer circumferential surface sealing member. The first flange portion is in contact with the first insulating plate via an end-face sealing member.
US08962204B2 Fuel cell system and method of controlling fuel cell system
A fuel cell stack includes a heat exchange unit that performs heat exchange between a gas mixture containing source hydrogen and a circulating gas and cooling water used for controlling the temperature of the fuel cell stack. A system controller adjusts the temperature of the cooling water by controlling a temperature control unit on the basis of the temperature of source hydrogen flowing into a junction at which the source hydrogen and a circulating gas are mixed such that the temperature of a source/recirculated hydrogen mixture that is mixed at the junction and that is supplied to the fuel cell stack is kept within a managed temperature range.
US08962201B2 Fuel cell apparatus
Disclosed is a fuel cell apparatus which can continue stable performance, can generate an electric power for a long period, and has a long service life. The fuel cell apparatus comprises: a fuel cell body comprising a power generation unit which can generate an electric power through the reaction between hydrogen and oxygen and a hydrogen generation member which can generate hydrogen through the reaction with water produced upon the generation of the electric power and can supply hydrogen generated to the power generation unit; and a reduction control unit which can control so as to reduce the hydrogen generation member that has been oxidized through the reaction with the produced water.
US08962196B2 Bio-battery with enhanced yield
A novel cell including first and second chambers containing a solvent and separated by a wall permeable to the solvent and impermeable to hydronium and/or hydroxyl ions; a first electrode in the first chamber; a second electrode in the second chamber; a first redox couple in the first chamber comprising a first oxidizer and a first reducer taking part in first oxidation-reduction reactions resulting in an electron exchange with the first electrode; a second redox couple in the second chamber comprising a second oxidizer and a second reducer taking part in second oxidation-reduction reactions resulting in an electron exchange with the second electrode, the wall being impermeable to the first and second redox couples; and first enzymes or first microorganisms placed in the first or second chamber and promoting a third oxidation-reduction reaction resulting transforming a first substance to a second substance comprising acid or alkaline species.
US08962191B2 Electrochemical cells having a electrode current collector extending into a positive electrode composition, and related methods
An electrochemical cell is presented. The electrochemical cell includes an elongated ion-conducting separator defining at least a portion of a first compartment; a positive electrode composition disposed in the first compartment, the positive electrode composition comprising at least one electroactive metal, at least one alkali metal halide, and at least one electrolyte. A positive current collector is further disposed in the first compartment such that a portion of the positive current collector extends into the positive electrode composition, and a primary dimension of the extended portion of the positive current collector is less than about 20% of a primary dimension of the first compartment. A related method for the preparation of an electrochemical cell is also presented.
US08962188B2 Anode compositions for lithium secondary batteries
A lithium secondary battery comprising a cathode, an anode, and a separator-electrolyte assembly or electrolyte layer disposed between the cathode and the anode, wherein the anode comprises: (a) an integrated nano-structure of electrically conductive nanometer-scaled filaments that are interconnected to form a porous network of electron-conducting paths comprising interconnected pores, wherein the filaments have a transverse dimension less than 500 nm; and (b) a foil of lithium or lithium alloy as an anode active material. The battery exhibits an exceptionally high specific capacity, an excellent reversible capacity, and a long cycle life.
US08962184B2 Anode active material and secondary battery comprising the same
Disclosed are an anode active material for secondary batteries, capable of intercalating and deintercalating ions, the anode active material including a core including a crystalline carbon-based material, and a composite coating layer including one or more materials selected from the group consisting of low crystalline carbon and amorphous carbon, and silicon oxide capable of intercalating and deintercalating ions, wherein the composite coating layer includes a matrix comprising one component selected from (a) the one or more materials selected from the group consisting of low crystalline carbon and amorphous carbon and (b) the silicon oxide capable of intercalating and deintercalating ions, and a filler including the other component, incorporated in the matrix, and a secondary battery including the anode active material.
US08962182B2 Batteries utilizing anode coatings directly on nanoporous separators
Provided is a separator/anode assembly for use in an electric current producing cell, wherein the assembly comprises an anode current collector layer interposed between a first anode layer and a second anode layer and a porous separator layer on the side of the first anode layer opposite to the anode current collector layer, wherein the first anode layer is coated directly on the separator layer. Also provided are methods of preparing such separator/anode assemblies.
US08962178B2 Battery pack
A battery pack having a can housing having an electrode assembly and electrolyte, this can may include a cap plate coupled to an open end of the can. A recess is provided on a surface of the cap plate. A metal plate made of a material different from the cap plate is embedded in the recess. The metal plate includes a plurality grooves on at least one surface.
US08962176B2 Module for electrical energy storage assemblies having a flat connecting strip
The invention relates to a module comprising at least two electrical energy storage assemblies (20), each storage assembly (20) comprising a first face topped by a cover (30) electrically connected to said energy storage assembly (20) and a second face opposite the first face, each cover being in contact with a respective end of a strip (40) in order to electrically connect the two storage assemblies (20), in which the strip (40) and the faces of the covers (30) in contact with the strip (40) are flat, the strip (40) being welded to the faces of the covers (30) along weld leads (50, 50′).
US08962174B2 Battery unit
A battery unit has a battery pack module that has a plurality of single cells, a control circuit board that has a control section that controls a charge and discharge in the battery pack module, and an accommodation case where the battery pack module and the control circuit board are accommodated. The control circuit board is disposed in a position above the battery pack module, and separated away from the base plate by a distance more than a distance from the base plate to a wall top end part of the wall section. Moreover, the submergence sensor is disposed in a position nearer to the base plate than to the wall top end part of the wall section that is in a space within the case 16 surrounded by the wall section.
US08962173B1 Lithium battery structures
This invention provides a novel battery structure that, in some variations, utilizes a mixed lithium-ion and electron conductor as part of the separator. This layer is non-porous, conducting only lithium ions during operation, and may be structurally free-standing. Alternatively, the layer can be used as a battery electrode in a lithium-ion battery, wherein on the side not exposed to battery electrolyte, a chemical compound is used to regenerate the discharged electrode. This battery structure overcomes critical shortcomings of current lithium-sulfur, lithium-air, and lithium-ion batteries.
US08962169B2 Battery pack for a hand-guided power tool
An exchangeable battery pack for an electric device has a housing with a first end face and a second end face opposite the first end face, wherein the first end is open. A housing cover closes off the first end face. Battery cells are disposed in the housing. Cell connectors electrically connect the cells with one another. An external electrical connector is disposed on the second end face. All of the battery cells are connected to the external electrical connector. The battery cells are charged and discharged through the external electrical connector. A cell holder secures several of the battery cells. An inner positional securing element is provided on an inner side of a sidewall of the housing and the cell holder interacts with the positional securing element.
US08962168B2 Storage battery module
A storage battery module 20 includes plural battery cells 320 in which a wound electrode group 322 having positive and negative electrodes, and positive and negative electrode collector plates 327a and 327b connected to the positive and negative electrodes are accommodated in a battery cell 321, and positive and negative external terminals 331 and 341 are provided to be exposed to outside of the battery case 321, a circuit board 350 including a temperature detecting wiring 302 of the battery cell 320 connected to the positive and negative external terminals 331 and 341, and a temperature sensor 381 for detecting a temperature of the battery cell 320 provided above the wiring 302.
US08962163B2 Aluminum alloy for anodization and aluminum alloy component
The present invention provides an aluminum alloy component having an anodic oxide film less causing cracks and high in surface smoothness, which is capable of reducing abrasion of a cutting tool regardless of the excellent machinability. The aluminum alloy component (1) has an anodic oxide film formed on a surface of a base metal of an aluminum alloy. The aluminum alloy consists of Fe: 0.5 to 2 mass %, Cu: 0.35 to 0.6 mass %, Mg: 0.35 to 1.3 mass %, Si: 0.2 to 1.3 mass %, Cr: 0.005 to 0.3 mass %, Mn: 0.01 to 0.3 mass %, Ti: 0.005 to 0.1 mass %, and the balance being inevitable impurities, wherein Zn is controlled to be less than 0.25 mass %, and wherein Al—Fe series crystals and Al—Fe—Si series crystals having a maximum grain diameter of 30 μm or less exist in the anodic oxide film in a dispersed manner with an average center-to-center distance of 10 to 100 μm, and a percentage of a total occupied area of the Al—Fe series crystals and Al—Fe—Si series crystals in the anodic oxide film is 5% or more.
US08962162B2 Enamel and ground coat compositions
A composition that upon firing, forms a non-stick enamel layer is disclosed. The composition can be applied to a metal substrate to provide a non-stick, durable coating for cooking surfaces. Also disclosed are methods of forming enamel layers and corresponding coated substrates. Various ground coats and related methods are also described. Furthermore, various multilayer coatings and structures are disclosed that include an enamel layer and a ground coat layer.
US08962157B2 Electron-transporting materials
Compounds of formula I may be used in optoelectronic devices wherein R1, R2 and R4 are, independently at each occurrence, H, a C1-C20 aliphatic radical, a C3-C20 aromatic radical, or a C3-C20 cycloaliphatic radical; R3 is H or a is, independently at each occurrence, 1 or 2; b is, independently at each occurrence, an integer ranging from 0-3; c is, independently at each occurrence, an integer ranging from 0-4; Ar is independently at each occurrence, H, or heteroaryl; and at least two of Ar are heteroaryl.
US08962155B2 Light emitting device based on a pyrromethene compound
A light emitting device material containing a pyrromethene compound represented by the general formula (1). It realized a luminescent element having a high luminescent efficiency and exellent color purity. Also provided is a luminescent element employing the materials.
US08962153B2 Hot-dip Zn—Al alloy coated steel sheet and producing method therefor
A hot-dip Zn—Al alloy coated steel sheet exhibiting a beautiful coating appearance with metallic luster, in which no spangle or very fine spangles are formed, and having excellent blackening resistance and a method for manufacturing the hot-dip Zn—Al alloy coated steel sheet are provided. The hot-dip Zn—Al alloy coated steel sheet includes a hot-dip Zn—Al alloy coating layer containing 1.0 to 10 percent by mass of Al, 0.2 to 1.0 percent by mass of Mg, 0.005 to 0.1 percent by mass of Ni, and the balance being Zn and incidental impurities on at least one surface of a steel sheet. The manufacturing method includes the steps of dipping the steel sheet into a hot-dip Zn—Al alloy coating bath and pulling up and cooling the steel sheet, wherein the steel sheet pulled up from the coating bath is cooled to 250° C. at a cooling rate of 1° C. to 15° C./sec.
US08962150B2 Steel fibre for reinforcing concrete or mortar having an anchorage end with at least two bent sections
A steel fiber for reinforcing concrete or mortar comprises a middle portion and an anchorage end at one or both ends of the middle portion. The middle portion has a main axis. The anchorage end is deflecting from the main axis of the middle portion in a deflection section. The anchorage end has n bent sections, with n equal or larger than 2. The steel fiber is configured so that when the steel fiber is in a stable position on a horizontal surface being vertically projected on this horizontal surface, the vertical projections in this horizontal surface of all of the n bent sections of an anchorage end are located at one side of the vertical projection in this horizontal surface of the main axis of the middle portion.
US08962149B2 Spot welded joint
Provided is a spot welded joint (10) which includes at least one thin steel plate with a tensile strength of 750 MPa to 1850 MPa and a carbon equivalent Ceq of equal to or more than 0.22 mass % to 0.55 mass % and in which a nugget (3) is formed in an interface of the thin steel plates (1A, 1B). In a nugget outer layer zone, a microstructure consists of a dendrite structure in which an average value of arm intervals is equal to or less than 12 μm, an average grain diameter of carbides contained in the microstructure is 5 nm to 100 nm, and a number density of carbides is equal to or more than 2×106/mm2.
US08962147B2 Powder metal component impregnated with ceria and/or yttria and method of manufacture
A powder metal component is made of compacted and sintered powder metal particles such as chromium-containing ferrous-based metal and is porous. Following sintering, the pores are impregnated with relatively smaller particles of ceria and/or yttria. The component is then heat treated and the presence of the impregnated ceria and/or yttria serve as nucleation sites for the formation of desirable oxides, such as chromium oxide, on the surface. The impregnated particles that lie below the protective oxide layer remain available throughout the life of the component in the event the original oxide layer becomes worn or damaged, wherein a renewed protective oxide is formed in such regions due to the presence of the impregnated particles.
US08962144B2 Reinforcing sheet for resin molded product, and structure and method for reinforcing resin molded product
A reinforcing sheet for a resin molded product includes a constraining layer, and a reinforcing layer laminated on the constraining layer. After being stuck to a polypropylene plate having a thickness of 2.0 mm and heated at 80° C. for 10 minutes, the reinforcing sheet for a resin molded product has a bending strength at a displacement of 1 mm at 90° C. which is not less than double a bending strength of the polypropylene plate having a thickness of 2.0 mm at a displacement of 1 mm at 90° C.
US08962141B2 Method for preparing a glass convenient for trimming, a glass thus obtained, and method for trimming such a glass
A method for making appropriate for trimming a glass comprising a hydrophobic and/or oil-repellent surface coating is provided, as well as the glass itself, in which the surface of the glass is coated with a temporary protective layer imparting to the glass a surface energy at least equal to 15 mJ/m2.
US08962139B2 Resin particle and method for producing the same
A resin particle including: a resin mother particle; and silica particles externally added onto a surface of the resin mother particle, wherein primary particles of the silica particles, the primary particles which have a volume average particle diameter of from 80 nm to 300 nm, a particle size distribution index of from 1.10 to 1.40, an average circularity of from 0.70 to 0.92 and an average circularity distribution index of from 1.05 to 1.50, and a proportion of the primary particles having an average circularity of 0.95 or more is not more 10% by number.
US08962136B2 Pressure-sensitive adhesive sheet for surface protection
A surface-protecting pressure-sensitive adhesive sheet includes: a substrate; and a pressure-sensitive adhesive layer that is provided on at least one side of the substrate and made from a polyester-based pressure-sensitive adhesive composition containing a crosslinking agent and a polyester including at least a lactic acid unit, a dibasic acid unit, and a glycol unit. The dibasic acid unit includes a dimer acid, the polyester has a weight average molecular weight of 20,000 to 200,000 and a glass transition temperature of −70 to −20° C. as measured using a differential scanning calorimeter at a temperature rise rate of 20° C./minute, the polyester-based pressure-sensitive adhesive composition has a hydroxyl value of 20 to 60 mgKOH/g, and the pressure-sensitive adhesive layer has a gel fraction of 85 to 99% by weight.
US08962133B2 Electrophotographic member, intermediate transfer member, image forming apparatus, and method for manufacturing electrophotographic member
An object of the present invention is to provide: an electrophotographic member which enhances image quality, prevents the lowering of a grade of an image even when images have been repeatedly output, and can remarkably enhance the stability of the grade of the image; an intermediate transfer member; and an image forming apparatus. The electrophotographic member includes a base layer and a surface layer, wherein the surface layer has a binder resin, perfluoropolymer fine particles, a fluorocarbon resin dispersing agent and a particular fluorine compound, wherein the perfluoropolymer fine particle has a fluorine compound carried on its surface.
US08962132B2 Solid polymer electrolyte composite membrane comprising a porous support and a solid polymer electrolyte including a dispersed reduced noble metal or noble metal oxide
A solid polymer electrolyte composite membrane and method of manufacturing the same. According to one embodiment, the composite membrane comprises a thin, rigid, dimensionally-stable, non-electrically-conducting support, the support having a plurality of cylindrical, straight-through pores extending perpendicularly between opposing top and bottom surfaces of the support. The pores are unevenly distributed, with some or no pores located along the periphery and more pores located centrally. The pores are completely filled with a solid polymer electrolyte, the solid polymer electrolyte including a dispersed reduced noble metal or noble metal oxide. The solid polymer electrolyte may also be deposited over the top and/or bottom surfaces of the support.
US08962130B2 Low density lightning strike protection for use in airplanes
Surface films, paints, or primers can be used in preparing aircraft structural composites that may be exposed to lightning strikes. Methods for making and using these films, paints or primers are also disclosed. The surface film can include a thermoset resin or polymer, e.g., an epoxy resin and/or a thermoplastic polymer, which can be cured, bonded, or painted on the composite structure. Low-density electrically conductive materials are disclosed, such as carbon nanofiber, copper powder, metal coated microspheres, metal-coated carbon nanotubes, single wall carbon nanotubes, graphite nanoplatelets and the like, that can be uniformly dispersed throughout or on the film. Low density conductive materials can include metal screens, optionally in combination with carbon nanofibers.
US08962127B2 Ultrathin, porous and mechanically stable nonwoven fabric and method for manufacturing
An ultrathin, porous, and mechanically stable nonwoven fabric, a method for manufacturing the fabric, and the fabric's use are described. A nonwoven fabric is described having a thickness of less than 30 μm, which is chemically and/or thermally bonded, whose maximum tensile load in at least one direction is at least 15 N/5 cm, whose stretching in this direction at maximum tensile load is 35% at the most, and which has a porosity of at least 25%. This nonwoven fabric may be used as a separator material or as a carrier material for diaphragms.
US08962126B2 Surface-coated cutting tool having hard-coating layer with excellent chipping resistance and fracturing resistance
A surface-coated cutting tool, which has a hard-coating layer with excellent chipping and fracturing resistances in a high speed intermittent cutting work, is provided. The surface-coated cutting tool includes a cutting tool body, which is made of WC cemented carbide or TiCN-based cermet, and a hard-coating layer, which is vapor deposited on the cutting tool body and has a lower layer and an upper layer. The lower layer is a Ti compound layer, and the upper layer is an aluminum oxide layer. There is a micropore-rich layer in the lower layer in the vicinity of the interface between the lower and upper layers. There are micropores with diameters of 2 to 70 nm in the micropore-rich layer. The diameters of the micropores in the micropore-rich layer shows a bimodal distribution pattern.
US08962125B2 Anti-chipping sheet
An anti-chipping sheet includes at least a substrate layer and a pressure-sensitive adhesive layer, wherein the substrate layer comprises laminated multiple ionomer layers, each of which comprises an ionomer produced by neutralizing carboxyl groups of an ethylene-unsaturated carboxylic acid copolymer with metal ions, one of the multiple ionomer layers is a high-rigidity ionomer layer, located at the outermost layer and not in contact with the pressure-sensitive adhesive layer of the substrate layer, and having stiffness of 200 N/mm2 or higher, and another one of the multiple ionomer layers is a low-rigidity ionomer layer, located toward the pressure-sensitive adhesive layer in relation to the outermost layer, and having stiffness of lower than 200 N/mm2.
US08962122B2 Sealing material
The present invention provides a sealing material having excellent water resistance for a long time. A sealing material A of the present invention comprises: a rubber resin sheet 1; and a thermoplastic resin foam layer 2 formed at least on one surface of the rubber resin sheet 1. The sealing material A has a 25% compressive strength in a thickness direction of 2 to 40 kPa as measured in accordance with JIS K6767 and the thermoplastic resin foam layer 2 has a closed cell ratio of 10 to 60%. As a result, the sealing material A has excellent water resistance right after the use thereof and even after a long time has elapsed, and is suitably used in various applications.
US08962112B2 Intermediate transfer medium
In an intermediate transfer medium, a substrate, protective layers having a layered structure of two or more layers, and a receiving layer are layered in this order. One layer in the protective layers having the layered structure contains, as a main component, one material or a mixture of two or more materials selected from the group consisting of polyesters having a high polymerization degree, a number-average molecular weight (Mn) of not less than 12,000 and a Tg of not less than 60° C., polycarbonates and polyester urethanes. Another layer in the protective layers having the layered structure contains one or more materials selected from the group consisting of polyvinyl alcohols, polyvinyl butyrals, polyvinyl acetals and polyvinyl pyrrolidones or includes a cationic resin, and the receiving layer contains a side chain-type aralkyl-modified silicone in an amount of 0.5-5% by weight on a base of the total weight of the receiving layer.
US08962109B2 Liquid crystal display
A liquid crystal display includes a liquid crystal cell; a back light including a light source; and a laminated polarizing plate including a protective film, a polarizing film, and a retardation film in sequence from the side of the back light, wherein the angle defined by any one of the long and short sides of the polarizing plate and the absorption axis of the polarization film is 45°, the retardation film has an in-plane slow axis parallel or orthogonal to the absorption axis of the polarizing film, and the liquid crystal display satisfies the formula: M=|δTD/δMD|≧2.0, where M represents the ratio of the dimensional change rates in the entire polarizing plate, δMD (%) represents a percent change of the polarizing plate in the absorption axis direction, and δTD (%) represents a percent change of the polarizing plate in the direction orthogonal to the absorption axis.
US08962108B2 Liquid crystal display panel and liquid crystal display
A liquid crystal display panel includes a liquid crystal cell, a first polarizing plate placed on one side of the liquid crystal cell, a second polarizing plate placed on the other side of the liquid crystal cell, a retardation film placed between the liquid crystal cell and the first polarizing plate, and a pressure-sensitive adhesive layer placed between the liquid crystal cell and the retardation film, wherein the first and second polarizing plates have absorption axes whose directions are substantially orthogonal to each other, the retardation film is a norbornene resin-containing stretched film and has a refractive index ellipsoid satisfying the relation nx≧nz>ny, and the pressure-sensitive adhesive layer includes a pressure-sensitive adhesive that may be produced by crosslinking a composition including a (meth)acrylate (co)polymer and a crosslinking agent including a peroxide as a main component. When the liquid crystal display panel is viewed from oblique directions, leakage of light and changes in color are small, and when the liquid crystal cell is recycled, the laminated film has a high level of easy peelability.
US08962105B2 Liquid crystal composition and liquid crystal display device
To provide a liquid crystal composition satisfying at least one of characteristics such as a high maximum temperature of a nematic phase, a low minimum temperature of the nematic phase, a small viscosity, a suitable optical anisotropy, a large negative dielectric anisotropy, a large specific resistance, a high stability to ultraviolet light and a high stability to heat, and so forth. To provide an AM device having a short response time, a large voltage holding ratio, a large contrast ratio, a long service life and so forth. The liquid crystal composition contains a specific compound having a polymerizable group as a first component and a specific compound having a large negative dielectric anisotropy and a low minimum temperature as a second component, and may contain a specific compound having a small viscosity or a large maximum temperature as a third component, and a liquid crystal display device includes the composition.
US08962102B2 Compounds and liquid-crystalline medium
The invention relates to compounds of the formula I, and to a liquid-crystalline medium, preferably having a nematic phase and negative dielectric anisotropy, which comprises one or more compounds of formula I, defined herein, for use in an electro-optical display, particularly in an active-matrix display based on the VA, ECB, PALO, FFS or IPS effect, and to the use of the compounds of the formula I for the stabilization of a liquid-crystalline medium which comprises one or more compounds of the formula II and one or more compounds of the formulae III-1 to III-4, defined herein.
US08962100B2 Method for making diamond composite materials
The invention relates to a method for depositing a diamond coating onto a substrate, said method resulting in the production of a coating characterized by a novel morphology of the diamond in the form of pyramids containing submicronic grains. The method is carried out by chemical vapor deposition by controlling the applied electric field.
US08962092B2 Paper sizing using an agent containing uniformly bound octenyl succinic anhydride groups made by the reaction of octenyl succinic anhydride onto a dispersed waxy starch
The application relates to an agent containing bound octenyl succinic anhydride groups made via the reaction of octenyl succinic anhydride onto a dispersed waxy starch, which provides significant improvements in paper porosity reduction, when added at a low level to a commodity surface starch dispersion and used to surface size paper.
US08962090B2 Variable-density carbon nanotube film and method for manufacturing the same
A method for making a variable-density carbon nanotube film is provided. A drawn carbon nanotube film, including a number of carbon nanotubes aligned along an aligned direction, is prepared. A number of thin regions are formed in the drawn carbon nanotube film along the aligned direction by reducing density of carbon nanotubes in each of the plurality of thin regions. A variable-density carbon nanotube film is provided and includes a number of thin regions and at least one normal region having a density of carbon nanotubes greater than that of the thin regions. The at least one normal region includes a number of carbon nanotubes substantially aligned along an aligned direction. The thin regions are arranged in the form of at least one row extending along the aligned direction.
US08962089B2 Method for the flow coating of a polymeric material
Method for flow coating a polymeric material, wherein a. at least one component (1) is inserted at an angle of 25° to 90° relative to the floor (5) into a holder (2), and b. the component (1) is coated from the upper edge (1a) with a varnish (3), containing 10 wt.-% to 30 wt.-% of 4-methyl-2-pentanone and/or derivatives thereof.
US08962088B2 Method and finish for concrete walls
A method for forming a uniform texture concrete wall using Shotcrete or other pneumatically projected concrete materials. The method generally includes forming an exterior face mixture from a concrete mixture wherein the large aggregates are removed such that when the face mixture is pneumatically applied to a base structure, the face mixture defines a uniform surface.
US08962086B2 Process for coating a surface of a substrate made of nonmetallic material with a metal layer
A process for coating a surface of a substrate made of nonmetallic material with a metal layer consisting of providing a substrate made of nonmetallic material; subjecting a surface of said substrate to a treatment for increasing the specific surface area thereof; subjecting the resulting surface to an oxidizing treatment; contacting the resulting substrate with a solution containing an ion of a metal from groups IB and VIII of the Periodic Table; obtaining a substrate comprising ions of a metal that are chemically attached to the nonmetallic material constituting the substrate on at least one of its surfaces; subjecting the ions to a reducing treatment to obtain a substrate comprising atoms of a metal that are chemically attached to the nonmetallic material constituting the substrate on a part of at least one of its surfaces; and contacting the resulting surface with a solution containing ions of a metal.
US08962084B2 Methods of applying a layer of material to a non-planar glass sheet
Methods apply a layer of material to a glass sheet having a non-planar shape. The methods can each include the step of providing the glass sheet having an initial non-planar shape including a thickness defined between a first sheet surface and a second sheet surface. The method further includes the step of at least partially flattening the glass sheet into an application shape. The method further includes the step of applying the layer of material to the first sheet surface while the glass sheet is in the application shape. The method then includes the step of releasing the glass sheet to relax into a post non-planar shape.
US08962082B2 Control system for non-contact edge coating apparatus for solar cell substrates
A non-contact edge coating apparatus includes an applicator for applying a coating material on an edge of a solar cell substrate and a control system configured to drive the applicator. The control system may drive the applicator along an axis to maintain a distance with an edge of the substrate as the substrate is rotated to have the edge coated with a coating material. The applicator may include a recessed portion into which the edge of the substrate is received for edge coating. For example, the applicator may be a roller with a groove. Coating material may be introduced into the groove for application onto the edge of the substrate. A variety of coating materials may be employed with the apparatus including hot melt ink and UV curable plating resist.
US08962080B2 Method for patterning a polymer layer and method for packaging a microbattery
The method for patterning a polymer layer arranged on a support comprises deposition of a layer made from a lithium-based polymerization inhibitor material on a first area of the support, deposition of a cationically polymerizable material on the polymerization inhibitor layer and on a second area of the support, application of polymerization treatment resulting in a non-solidified sacrificial layer in the first area and the polymer layer in the second area, and elimination of the sacrificial layer.
US08962079B2 Manufacturing optical elements
A method includes the steps of: providing a substrate; providing a tool having, on a replication side, a plurality of replication sections, each replication section defining a surface structure of one of an optical element(s), the tool further including at least one contact spacer portion, the contact spacer portion protruding, on the replication side, further than an outermost feature of the replication sections; aligning the tool with a feature of the substrate and bringing the tool and a first side of the substrate together, with replication material between the tool and the substrate, the contact spacer portion contacting the first side of the substrate, and thereby causing the spacer portion to adhere to the first side of the substrate, thereby producing a substrate-tool-assembly; dislocating the substrate-tool-assembly to a hardening station; causing the replication material to harden at the hardening station; and separating the tool from the substrate with the hardened replication material adhering to the substrate.
US08962074B2 Device and method for applying glue
A device for applying glue onto labels, includes a drum rotatable about a predetermined rotational axis and, a glue application unit for applying glue onto an external surface of the rotatable drum. The glue application unit includes a receiving space for receiving the glue as well as a supply unit for applying the glue to the receiving space which is arranged relative to the drum such that any glue present in the glue application unit contacts the drum in a predetermined contact area. The glue application unit includes a first wall element, which contacts the drum during operation, and a second wall element arranged behind the first wall element in the direction of movement of the drum and which also contacts the drum. At least one wall element is elastically pressed against the external surface of the drum.
US08962071B2 Process for cold-in-place recycling using foamed asphalt and lubrication additive
Cold-in-place asphalt recycling is disclosed. A foamed asphalt may be produced by injecting water and optionally compressed air into a hot asphalt stream. A lubricating surfactant may be added to the hot asphalt stream to improve performance. The foamed asphalt may be mixed with reclaimed material to provide a uniformly coated paving material that can compacted to a desired density.
US08962066B2 Coating for cooling air holes
A method of repairing a component removes a prior coating from an underlying metal substrate. Small cooling air holes extend through the substrate and the coating that is to be removed. A new coating layer is placed on the metal substrate, and over the existing cooling air holes. The location of the cooling air holes is identified by inspecting the coated component for the location of indicators of the coating passing over the cooling air holes. The identified location of the indicators is used to control a cutting tool to remove any new coating from the cooling air holes. The basic method may also benefit new manufacture.
US08962062B2 Methods of manufacturing end effectors for energy-based surgical instruments
A method of manufacturing an end effector for a surgical instrument includes providing a substrate wherein at least an outer periphery of the substrate is formed from an electrically-insulative material. The method further includes forming at least one ridge on the outer periphery of the substrate and depositing an electrically-conductive material onto the at least one ridge to form at least one electrode.
US08962059B1 Bio-based oil composition and method for producing the same
A method of extracting oil from a byproduct stream of a bio-based ethanol production process and a organic composition resulting from the method is provided. The method includes applying an oil concentrator to a byproduct stream, mixing the oil concentrator with the byproduct stream, and separating the oil from the byproduct stream. An organic composition comprising oil derived from a byproduct stream of a bio-based ethanol production process and an oil concentrator is also provided.
US08962056B2 Fiber particle size reduction in fiber-containing food slurries
Techniques are described to increase product viscosity in fiber-containing food slurries having a given amount of food solids. The techniques employ one or more PSR operations as the last unit operation prior to filling to reduce particle size within the food slurry and increase product viscosity. In one or more implementations, the PSR operation may comprise an aseptic cold PSR operation such as aseptic cold homogenization. In embodiments, the PSR operation may further be controlled to reduce variability in the viscosity of the finished product.
US08962054B2 Methods of making snack food products and products made thereby
Methods of making low-fat or fat free snack food products, and products made according to the methods, in which food pieces are subjected to enzyme and/or cation treatment and/or specific cooking and/or drying techniques, to provide for snack food products having the texture, flavor, and other characteristics of conventional full-fat products.
US08962053B2 Device for heating and/or frothing a beverage
The present invention relates to a device for heating and/or frothing a beverage (19), including: a first duct (21) connectable to an upstream steam source and having a first valve (31) configured to be opened and closed and to enable or prevent steam flow into the duct; a second duct (22) connectable to the upstream steam source and having a second valve (32) configured to be opened and closed and to enable or prevent steam flow into the duct; mixing means (14), which are connected to a common point of the first and second ducts (21, 22), are located downstream of the first duct (21) and the first valve (31) and downstream of the second duct (22) and the second valve (32) and are arranged to introduce and mix at least steam into the beverage. The device further comprises a Venturi assembly (22a) configured to operate by Venturi effect in order to mix air with steam in one the two ducts when the other of the two ducts is closed. Thanks to the device of the invention, heated beverages can be obtained in considerably quick times. The invention also relates to a method for heating and/or frothing beverages, as well as to an espresso coffee machine including the device.
US08962052B2 Carbonated beverages
Acidulated carbonated beverage containing a foam control agent and/or carbon dioxide control agent. The control agent contains a polyoxyethylene sorbitan fatty acid ester or a polyethylene glycol fatty acid ester.
US08962046B2 Satiety inducing products and a method of their production
The invention relates to a food product inducing satiety with the aim of contributing to weight management. The product contains as its essential ingredients viscous soluble dietary fiber or other thickening agent and fat or fatty acids. A preferred component contained in the product is a barley or oat bran concentrate rich in β-glucan. The product may have a pasty consistency, or it may have a particulate consistency and can be turned to a paste by addition of water.
US08962044B2 Radiopaque bone repair mixture and method of use
A composition of a bone repair mixture has a quantity of allograft particulate bone having a bone particle distribution of particle sizes less than 700 micron and a quantity of biologic carrier material intermixed with the particulate bone. The biologic carrier material is one of fascia, deep fascia or a fascia mixture. Preferably, the carrier material is exclusively fascia lata.
US08962043B2 Visual performance and/or macular pigmentation
Disclosed is a composition comprising MZ for use as a dietary supplement or food additive for oral consumption for improving the visual performance of a human subject.
US08962039B2 Method of treatment of neurodegenerative or neuro-muscular degenerative diseases and therapeutic agent to treat the same
Use of high doses above 1 gm per day of ascorbic acid or the derivatives thereof for the treatment of neurodegenerative and neuro-muscular degenerative diseases and disorders, in particular amytrophic lateral sclerosis, multiple sclerosis, alzheimer's disease, parkinson's disease, and muscular dystrophy is disclosed. Preferably the dose includes mannitol which facilitates the delivery of ascorbic acid to the target cells in the brain. Still further the said dose includes zinc citrate for preventing formation of kidney stones. Dose compositions for various routes of application such as oral, intravenous, intramuscular, nasal and in the form of transdermal patches are discussed.
US08962035B2 Variable density tissue graft composition and methods of making and using the same
Disclosed are tissue graft compositions made of materials having different densities, methods of making, and methods of treatment for restoring tissues in a patient.
US08962033B2 Method for improved fibrin sealing
The present invention relates to a fibrin matrix, its preparation and use for effectively sealing a defect in a mucosa or other moist tissue.
US08962027B2 Materials comprising water-soluble polymer particles and methods of making and using them
One aspect of the invention relates to new materials for storing, protecting, selectively releasing, and applying active ingredients (e.g. pharmaceuticals and other chemicals). In certain embodiments, the invention provides materials impregnated with water-soluble polymer particles which contain active ingredients which may be selectively released and dispensed in response to contact with water or another liquid.
US08962026B2 Nanoemulsion therapeutic compositions and methods of using the same
The present invention relates to therapeutic nanoemulsion compositions and to methods of utilizing the same. In particular, nanoemulsion compositions are described herein that find use in the treatment and/or prevention of infection (e.g., respiratory infection (e.g., associated with cystic fibrosis)), in burn wound management, and in immunogenic compositions (e.g., comprising a Burkholderia antigen) that generate an effective immune response (e.g., against a bacterial species of the genus Burkholderia) in a subject administered the immunogenic composition. Compositions and methods of the present invention find use in, among other things, clinical (e.g. therapeutic and preventative medicine), industrial, and research applications.
US08962025B2 Rapidly acting dry sealant and methods for use and manufacture
Compositions, methods, and kits are provided for sealing applications. Compositions are prepared by combining a first cross-linkable component with a second cross-linkable component to form a porous matrix having interstices, and combining the porous matrix with a hydrogel-forming component to fill at least some of the interstices. The compositions exhibit minimal swelling properties.
US08962021B2 Solid pharmaceutical composition comprising telithromycin
This invention relates to a solid pharmaceutical tablet comprising telithromycin or a salt thereof as an active ingredient in combination with a plasticizing effective amount of a microcrystalline cellulose diluent having a plastic behavior. Optional ingredients include a binder, a disintegrating agent and a lubricant, and the tablet may be optionally coated with a film-coating agent.
US08962015B2 Orally bioavailable lipid-based constructs
The present invention is embodied by a composition capable of chaperoning a typically non-orally available therapeutic or diagnostic agent through the environment of the digestive tract such that the therapeutic or diagnostic agent is bioavailable. The composition may or may not be targeted to specific cellular receptors, such as hepatocytes. Therapeutic agents include, but are not limited to, insulin, calcitonin, serotonin, and other proteins. Targeting is accomplished with biotin or metal based targeting agents.
US08962010B2 Intravaginal drug delivery devices for the delivery of macromolecules and water-soluble drugs
An intravaginal drug delivery device comprises a device body comprising a hydrophobic carrier material having at least one channel defining at least one opening to the exterior of said device body, said at least one channel being adapted to receive at least one drug-containing insert; at least one drug-containing insert positioned in said at least one channel, said drug-containing insert capable of releasing a pharmaceutically effective amount of at least one drug suitable for intravaginal administration and containing about 1% to about 70% of at least one water-soluble release enhancer, both the drug and the water-soluble release enhancer dispersed in an insert carrier material; wherein said hydrophobic carrier material and said insert carrier material may be the same or different; and wherein said at least one drug-containing insert is exposed on said exterior of said device body when said intravaginal drug delivery device is in use.
US08962005B2 Gastric reflux resistant dosage forms
Gastric resistant film-forming compositions are described herein. The composition comprises a gastric resistant natural polymer, a film-forming natural polymer, and optionally a gelling agent. Suitable gastric resistant natural polymers include polysaccharides such as pectin and pectin-like polymers. The film-forming composition can be used to prepare soft or hard shell gelatin capsules which can encapsulate a liquid or semi-solid fill material or a solid tablet (Softlet®) comprising an active agent and one or more pharmaceutically acceptable excipients. Alternatively, the composition can be administered as a liquid with an active agent dissolved or dispersed in the composition. The compositions are not only gastric resistant but may also prevent gastric reflux associated with odor causing liquids, such as fish oil or garlic oil, encapsulated in a unit dosage form and esophageal irritation due to the reflux of irritant drugs delivered orally.
US08962004B2 Encapsulated triazinyl sulfonylurea herbicide and methods of use
The invention relates to compositions including an encapsulated triazinyl sulfonylurea. The invention further relates to methods for controlling weeds. The invention additionally provides methods for producing such compositions.
US08962003B2 Insect behaviour modifying compounds
The invention provides methods for controlling thrips populations using thrips-repelling and/or thrips-attracting agents. The invention also provides methods of preventing or minimizing damage to plants by use of the same.
US08962001B2 Nuclease inhibitors and methods for their use
A class of anionic oligomers and polymers that function for inhibition of nucleases, particularly RNase. Specific inhibitors include mixtures of oligomers of vinyl sulfate. Methods for inhibition or inactivation of one or more nucleases in vitro which comprises the step of contacting the one or more nucleases in a biological medium with one or more of the anionic oligomeric or polymeric inhibitors of this invention. Kits for carrying out a biological procedure, biological reaction and/or a biological assay containing one or more inhibitors of this invention. The use of oligomers and/or polymers of this invention as additives in buffers or reagents. The inhibitors of the invention can also be attached to surfaces to provide for removal of nucleases from media, solutions or other liquids in contact with the solid.
US08961999B2 Methods and compositions for bone formation
A method and system to induce bone growth by locally delivering bone morphogenetic proteins (BMPs) to the target location for a prolonged period without invasive procedures are disclosed. The new bone growth is induced by delivering cells producing BMPs from transduced viral vectors to the target cite. In various embodiments, the cells are encapsulated in hydrogel microspheres that are non-degradable or degradable by enzymes produced during the bone formation process. Various embodiments may be used to induce spinal fusion or repair critical bone defects.
US08961995B2 Methods and compositions for alphavirus replicons
The present invention provides alphavirus replicons and methods of their use in producing heterologous protein.
US08961992B1 Epsigam fusion protein
Epsi-gam provides a novel fusion protein with the ability to cross-link either of the FcεRI or FcεRII cell surface receptors with an FcγRIIb cell surface receptor in order to block IgE-mediated biological responses.
US08961986B2 Peptide composition
There is provided a method for selecting a tolerogenic peptide by selecting a peptide which is capable of binding to an MHC class I or II molecule without further processing. There is also provided a peptide selected by such a method and its use in a pharmaceutical composition and a method to treat and/or prevent a disease. The present invention also relates to a composition which comprises the following myelin basic protein peptides: MBP 30-44; MBP 83-99; MBP 131-145; and MBP 140-154. The composition may be used to treat a disease, in particular multiple sclerosis and/or optical neuritis and the invention also relates to such uses and methods.
US08961985B2 Immunotherapy against several tumors including neuronal and brain tumors
The present invention relates to peptides, nucleic acids and cells for use in immunotherapeutic methods. In particular, the present invention relates to the immunotherapy of cancer. The present invention furthermore relates to tumor-associated cytotoxic T cell (CTL) peptide epitopes, alone or in combination with other tumor-associated peptides that serve as active pharmaceutical ingredients of vaccine compositions that stimulate anti-tumor immune responses. The present invention relates to 30 peptide sequences and their variants derived from HLA class I and class II molecules of human tumor cells that can be used in vaccine compositions for eliciting anti-tumor immune responses.
US08961984B2 Surface-coated structures and methods
The present invention relates to a method for covalently attaching a compound to a stainless steel, tin, iron, or titanium substrate, by contacting exposed surface(s) of the substrate with a synthetic pilin peptide containing a disulfide loop derived from the C-terminal receptor binding protein of Type IV P. aeruginosa (T4P) pilin, to bind the pilin peptide to the exposed surface(s), and covalently attaching the compound to the pilin peptide. Also disclosed are a substrate formed by the method and a biosensor device that uses the uses. Also disclosed are methods for improving the corrosion resistance, adhesive force, hardness and electron work function of certain metals.
US08961969B2 Antagonist antibodies against EphB3
EphB3-specific antibodies are provided, along with pharmaceutical compositions containing such antibody, kits containing a pharmaceutical composition, and methods of preventing and treating an EphB3-related disease or disorder.
US08961968B2 Human monoclonal antibodies against CD25
Isolated human monoclonal antibodies which bind to and inhibit human CD25, and related antibody-based compositions and molecules, are disclosed. The human antibodies can be produced by a hybridoma, a transfectoma or in a nonhuman transgenic animal, e.g., a transgenic mouse, capable of producing multiple isotypes of human monoclonal antibodies by undergoing V-D-J recombination and isotype switching. Also disclosed are pharmaceutical compositions comprising the human antibodies, nonhuman transgenic animals, hybridomas and transfectomas which produce the human antibodies, and therapeutic and diagnostic methods for using the human antibodies.
US08961964B2 High concentration antibody and protein formulations
The present application relates to highly concentrated antibody and protein formulations with reduced viscosity that are stable, relatively isotonic and are of low turbidity. The formulations are particularly suitable for subcutaneous administration. The application further describes articles of manufacture containing such formulations and method for using them to treat disorders treatable by the formulated antibody or protein.
US08961963B2 Pharmacological composition whereby statin and COQ10 compounds are enhanced
Disclosed is a pharmaceutical natural composition containing both statin compounds (mevinolin and mevinolinic acid) serving as cholesterol biosynthesis inhibitors and coenzyme Q (ubiquinone-10: CoQ10 and ubiquinone-9: CoQ9) compounds which are substances that inhibit factors causing complications such as myalgia involved in long-term use of the statin, prepared using Monascus sp. and natural medicinal substances such as ginseng, mushrooms and cereals.
US08961962B2 Acid ceramidase and mammalian cell survival
The present invention relates to methods of promoting the survival of cells by treating the cells with acid ceramidase. A kit for promoting ex vivo cell survival is also disclosed, as is a method of predicting in vitro fertilization outcome of a female subject.
US08961959B2 Glucosylceramide synthase inhibitors and therapeutic methods using the same
Glucosylceramide synthase inhibitors and compositions containing the same are disclosed. Methods of using the glucosylceramide synthase inhibitors in the treatment of diseases and conditions wherein inhibition of glucosylceramide synthase provides a benefit, like Gaucher disease and Fabry disease, also are disclosed.
US08961957B2 Therapy and method for intratumorally introducing cytotoxic T lymphocyte and/or NKT cell with anti-TNF and/or anti-IL-10
The invention relates to therapy and methods of applying the therapy to cancer patients. The invention includes introducing intratumorally cytotoxic T lymphocyte and/or NKT cells, and prior to, coincident with, or following introducing intratumorally the cytotoxic T lymphocyte and/or NKT cells, introducing intratumorally anti-TNF and/or anti-IL-10 to the patient. The cytotoxic T lymphocyte and/or NKT cells can be induced by the intratumoral introduction of immature dendritic cells to the patient. This therapy of the invention can be effective to regress, reduce or eliminate tumor cells in tumor tissue of the patients in the absence of radiation therapy.
US08961956B2 Mesenchymal stromal cells and uses related thereto
The present invention generally relates to novel preparations of mesenchymal stromal cells (MSCs) derived from hemangioblasts, methods for obtaining such MSCs, and methods of treating a pathology using such MSCs. The methods of the present invention produce substantial numbers of MSCs having a potency-retaining youthful phenotype, which are useful in the treatment of pathologies.
US08961953B2 Synbiotic mixture
This invention relates to a preparation comprising N-acetyl-lactosamine and/or an oligosaccharide containing N-acetyl-lactosamine and a probiotic Lactobacillus sp. The invention extends to nutritional compositions comprising said preparation and to the use of the preparation in the prevention and treatment of pathogenic infections of the gastro-intestinal and upper respiratory tracts.
US08961952B2 Extruded non-replicating probiotic micro-organisms and their health benefits
The present invention generally relates to the field of probiotic micro-organisms, in particular to the field of non-replicating probiotic micro-organisms. Embodiments of the present invention relate to compositions comprising probiotic micro-organisms that were rendered non-replicating by extrusion. Such compositions may be used to treat or prevent disorders that are related to a compromised immune system.
US08961951B2 Baculoviruses with enhanced virion production and a method for the production of baculoviruses
The present invention provides a method for restoring budding capability to GP64null baculoviruses including gp64null AcMNPV by expressing therein a portion of the VSV G protein gene or a truncated “stem” portion of the GP64 gene. Other embodiments provide methods to use portions of the G-stem or GP64 protein to target foreign proteins for display on virions.
US08961949B2 Polymer-metal complex composite having MRI contrast ability and MRI contrasting and/or antitumor composition using the same
The present invention provides a polymer-metal complex composite, which comprises a block copolymer capable of serving as a constituent member of a polymeric micelle and a metal complex having MRI contrast ability, accumulates in a tumor-specific manner, achieves high image contrast even in a small amount, and has reduced side effects and a long retention time in blood.The polymer-metal complex composite of the present invention comprises a block copolymer (A) represented by general formula (a) and a metal complex (B) having MRI contrast ability, wherein the composite comprises a structure in which a carboxyl anion of poly(carbo) in the copolymer (A) is attached to the metal complex (B) via a metal atom (M).
US08961947B2 Polymeric tissue sealant
Methods for making biomaterials for use as a tissue sealant, kits containing precursors for forming the biomaterials, and the resulting biomaterials are described herein. The biomaterials are formed from a composition comprising at least a first and a second precursor molecule, wherein: i) the first precursor molecule is a poly(ethylene glycol) based polymer having x nucleophilic groups selected from the group consisting of thiol or amino groups, wherein x is greater than or equal to 2 ii) the second precursor molecule is of the general formula: A-[(C3H6O)n—(C2H4O)m—B]i wherein m and n are integers from 1 to 200 i is greater than 2 A is a branch point B is a conjugated unsaturated group The precursors are selected based on the desired properties of the biomaterial. Optionally, the biomaterials contain additives, such as thixotropic agents, radiopaque agents, or bioactive agents. In the preferred embodiment, the biomaterials are used to reduce, inhibit, or contain loss of a biological fluid or gas in a patient.
US08961946B2 Hair processing agent and method for permanent waving hair
Provided are hair processing agents capable of permanent waving hair even at a neutral to weakly acidic pH range that causes less irritation to the skin, and hair processing agents in which an unpleasant odor is masked. Hair processing agents contain at least one compound represented by the formula (2). Hair processing agents contain a compound of the formula (2) and at least one compound (ii) selected from thioglycolic acid, thiolactic acid, cysteine, acetylcysteine, cysteamine, acylcysteamine, salts thereof and ester derivatives thereof. Hair processing agents contain a compound of the formula (2), a surfactant and water, and are emulsified. Hair processing agents contain a compound of the formula (2) and a specific perfume. wherein X is a structure selected from —O—, —S—, —NH— and —NR1—; R1 is an alkyl group of 1 to 6 carbon atoms; Y is an oxygen atom or a sulfur atom; in the formula (1), Z is a divalent organic residue having at least one mercapto group; in the formula (2), R is a divalent organic residue optionally having a mercapto group; and R2 is a hydrogen atom or an alkyl group of 1 to 6 carbon atoms.
US08961945B2 Cationic polyglyceryl compositions and compounds
Provided are polyglyceryl compositions comprising one or more polyglyceryl compounds having: (a) a node structure comprising at least three contiguous glyceryl remnant units; (b) one or more cationic groups each linked to the node structure by an independently selected linking group; and (c) one or more hydrophobic moieties each independently (i) linked to the node structure by a linking group, or (ii) constituting a portion of one of the one or more cationic groups, wherein the composition has an average degree of polymerization determined by hydroxyl value testing (DPOH) of from about 3 to about 20. Also provided are polyglyceryl compounds which may compose such compositions, and uses of the polyglyceryl compositions and compounds.
US08961944B2 Use of delta-tocopheryl-carbohydrate as a depigmenting agent
The present invention relates to a cosmetic or pharmaceutical composition for cutaneous application, whose goal is the depigmentation of the skin.
US08961943B2 O/W-emulsifiers, O/W-emulsions and methods of manufacture thereof
O/W-emulsifiers are described, comprising: (a) 30-50% by weight of hardened palm oil glycerides; (b) 15-35% by weight of potassium cetyl phosphates; (c) 20-30% by weight of cetyl alcohol, and (d) 5-15% by weight of potassium phosphate, in each case with respect to the total mass of the emulsifier. Further described are corresponding O/W-emulsions, comprising an aqueous phase, an oil phase dispersed in the aqueous phase and between 0.25 and 15% by weight of the abovementioned O/W-emulsifier. Finally, also described are methods for manufacturing such an O/W-emulsion.
US08961939B2 Compositions and related methods for oral wellness
Disclosed are compositions, apparatus, and related methods and systems for oral health care.
US08961935B2 MRI contrast agent coated with carboxylated mannan and method for producing the same
The present invention relates to a magnetic resonance imaging (MRI) contrast agent coated with carboxylated mannan, particularly a carboxylated mannan coated superparamagnetic MRI contrast agent specifically targeting antigen presenting cells and having excellent in vivo stability, and a method for producing the same. The MRI contrast agent coated with carboxylated mannan of the present invention can provide excellent in vivo stability and biocompatibility owing to its high surface negative charge, and can be introduced specifically into antigen presenting cells owing to mannose of mannan, so as to visualize the antigen presenting cells and the tissue containing the antigen presenting cells in MRI.
US08961922B2 Hydrogen production process
A method for producing hydrogen from water is provided. The hydrogen production process includes splitting water into hydrogen and oxygen, wherein the process includes decomposing sulfuric acid into water, sulfur dioxide and oxygen through a reaction of formula (X1) by using solar thermal energy, wherein at least a part of the elementary reaction of formula (X1-1) is performed using thermal solar energy, and at least a part of the elementary reaction of formula (X1-2) is performed using additional thermal energy other than solar thermal energy, and wherein the heating temperature by the additional thermal energy is higher by 10° C. or more than the heating temperature by the solar thermal energy, and at least a part of the additional thermal energy is generated in a reaction vessel: (X1) H2SO4→H2O+SO2+1/2O2, (X1-1) H2SO4→H2O+SO3, and (X1-2) SO3→SO2+1/2O2.
US08961921B2 Apparatus and method for producing liquid ferrate
A method for producing a ferrate solution by producing a ferrate intermediate material and then combining the intermediate material with a halogen or ozone solution.
US08961920B1 Methods of altering the color of a diamond by irradiation and high-pressure/high-temperature processing
Embodiments of methods of altering the color of diamonds are disclosed. In an embodiment, a method for altering the color of diamonds includes identifying and selecting a diamond having a suitable nitrogen content, HPHT processing the selected diamond under diamond-stable conditions to alter the color of the selected diamond from a first color to a second color, irradiating the HPHT-processed diamond with an electron source having an energy between about 1 MeV and about 20 MeV so as to alter the color of the selected diamond from the second color to a third color, and annealing the irradiated diamond either under partial vacuum conditions, or under HPHT diamond-stable conditions so as to alter the color from the third color to a fourth color (e.g., pink, red, or purple, depending on the nitrogen content of the selected diamond).
US08961918B2 Thermal annealing process
A method for processing a substrate is provided; wherein the method comprises applying a film of a copolymer composition, comprising a poly(styrene)-b-poly(dimethylsiloxane) block copolymer component to a surface of the substrate; optionally, baking the film; subjecting the film to a high temperature annealing process under particularized atmospheric conditions for a specified period of time; followed by a treatment of the annealed film to remove the poly(styrene) from the annealed film and to convert the poly(dimethylsiloxane) in the annealed film to SiOx.
US08961916B1 Methods to control flue gas and inorganics precipitation
This invention presents innovative methods for desulfurizing flue gas in conjunction with selective inorganics recovery using calcium chloroaluminate or calcium chloroferrate as a layered double hydroxide reagent. One of the aspects of such methods is based on scrubbing SO2 in a standalone closed loop. Further aspects of such methods are based on scrubbing SO2 by the natural alkalinity of a saline stream as a once-through sink along with controlled precipitation of magnesium hydroxide and a calcium-based mineral in a standalone basis; or in conjunction with desalination methods and/or enhanced hydrocarbons recovery.
US08961915B1 Wet scrubber for ammonia capture
A method for removing ammonia from a gas stream divides the gas steam into a plurality of separate gas streams and sprays a dilute acid solution into the streams. The acid solution is aqueous sulfuric acid and ammonium sulfate is produced. A device is used to divide the gas stream, the device having a plurality of conduits in fluid communication with a plenum. Spray nozzles are located in each conduit to spray the acid solution into the gas streams. The device creates less than 10 Pa back pressure to the gas stream.
US08961914B2 8-ring small pore molecular sieve with promoter to improve low temperature performance
Described is a selective catalytic reduction catalyst comprising an 8-ring small pore molecular sieve promoted with copper and an alkaline earth component. The catalyst is effective to catalyze the reduction of nitrogen oxides (NOx) in the presence of a reductant. A method for selectively reducing nitrogen oxides is also described.
US08961911B2 Selective leach recovery of zinc from a composite sulphide ore deposit, tailings, crushed ore or mine sludge
Zinc and lead are usually concomitantly present in Zn—Pb ores and tailings. A novel non-polluting hydrometallurgical process for selectively leaching and recovering zinc (Zn) from a composite lead (Pb) and zinc sulphide containing mineral, crushed untreated rock or unconsolidated mineral particles, mill tailings and/or agglomerated or unagglomerated sulphidic zinc containing waste material without necessitating smelting and refining operation has been developed. A combination of selected oxidant and alkali metal hydroxide has been found effective. A leachant consisting of e.g. a mixture of sodium hydroxide (NaOH) and sodium hypochlorite (NaOCl) is employed to selectively dissolve zinc sulphide at high pH at standard temperature and pressure (STP). The kinetics of leaching along with the effect of varying concentration (preferably of sodium hydroxide and sodium hypochlorite) were systematically investigated. Feed ore containing diverse set of minerals e.g. sulphides and carbonates can also be conveniently treated to selectively and almost quantitatively recover zinc as high purity zinc carbonate. This technology can be employed either in-situ or ex-situ based on the amenability of a particular type of mineral deposit or feed ore.
US08961908B1 Miniature western blot membrane incubation system
An incubation system for incubating membranes in western blot experiments featuring a base with an inner cavity adapted to hold membranes and small amounts of solutions and a lid that can pivot between an open and closed position to respectively allow and prevent access to the inner cavity. A gasket is disposed in between the lid and base to provide a water-tight seal between the lid and base. The systems can be stacked atop one another to allow for multiple systems to be placed atop a moving platform such as a rocking platform or an orbital shaker.
US08961907B2 Apparatus for the detection and analysis of particles in fluids
The invention relates to apparatus for the detection of particles and for particle analysis. The apparatus comprises a sample holder comprising a base and a projection extending from the base. The base includes a contact region where, in use, the surface of a fluid sample may contact the projection. The surface of at least the contact region of the projection exhibits properties that allow the surface of the contact region to be substantially wetted by a fluid sample when the apparatus is in use so that the fluid sample forms a meniscus having its apex in contact with the contact region of the projection. The invention also relates to methods for using the apparatus.
US08961904B2 Microfluidic chip
A microfluidic chip orients and isolates components in a sample fluid mixture by two-step focusing, where sheath fluids compress the sample fluid mixture in a sample input channel in one direction, such that the sample fluid mixture becomes a narrower stream bounded by the sheath fluids, and by having the sheath fluids compress the sample fluid mixture in a second direction further downstream, such that the components are compressed and oriented in a selected direction to pass through an interrogation chamber in single file formation for identification and separation by various methods. The isolation mechanism utilizes external, stacked piezoelectric actuator assemblies disposed on a microfluidic chip holder, or piezoelectric actuator assemblies on-chip, so that the actuator assemblies are triggered by an electronic signal to actuate jet chambers on either side of the sample input channel, to jet selected components in the sample input channel into one of the output channels.
US08961903B2 Microfluidic device and method for fluid clotting time determination
A microfluidic passive device and a method for determining clotting time are described, of a fluid medium such as blood, of low production cost which can therefore be disposable. When optimised to determine blood clotting time, it requires a minimal whole blood sample (<5 μL) and it is particularly suited to INR or PT determination, which can be used autonomously by patient without venipuncture. Monitoring, and processing means to interpret the results are comprised in an external coagulometer device. A production method for the manufacture of the microfluidic device is also provided.
US08961902B2 Method and apparatus for analyte processing
A system for processing analytes in samples includes an instrument and a cartridge. The cartridge includes fluid inputs, input and output valve assemblies, processing devices, fluid reservoirs, and channels for carrying samples from the fluid inputs to the fluid reservoirs. The valve assemblies include valves adapted to form a sealed fluid chamber in response to force applied by a movable head assembly of the instrument. Each fluid reservoir is adapted to mate and align with an air displacement pump interface member. A valve assembly includes a recess wall surrounding a recess and a valve assembly wall surrounding both the recess and the recess wall. The recess wall and the valve assembly walls are adapted to mate with and seal against a flexible sheet covering the recess, the recess wall, and the valve assembly wall. The cartridge and instrument include complementary features for finely and coarsely aligning instrument assemblies with portions of the cartridge.
US08961890B2 Purifying apparatus using photocatalytic sheet
Provided is a purifying apparatus, which includes ultraviolet lamps and an ozone lamp having different wavelengths from one another and disposed in tubes to remove bacteria, VOC, bad odors in water or air, and these tubes are arranged in a serial or parallel way. Folds are formed at inner ends of the spiral photocatalytic sheets which are in contact with the lamps and the respective lamps are inserted into to increase the contact area with air or water and the one with the lamp, thereby preventing the lamp from being damaged. The purifying apparatus includes: an outer case having an inlet and an outlet; a spiral photocatalytic sheet to be inserted into the outer case; a UV lamp to be inserted into the spiral photocatalytic sheet, wherein folds are disposed at an inner side of the spiral photocatalytic sheet where a space for inserting the UV lamp is formed.
US08961888B2 Plasma generator
To provide a plasma generator having plasma-generating zone of increased volume.A plasma generator 110 has a cylindrical casing 11 made of a sintered ceramic produced from alumina (Al2O3) as a raw material. The casing 11 has a slit-like gas inlet 11i and a plurality of cylindrical gas outlets 11o. From the gas inlet 11i to the top of the plasma-generating zone P, the slit width (the front-to-back direction with respect to the sheet of FIG. 2.A, and the left-to right direction in FIG. 2.B) is adjusted to 1 mm, and gas outlets 11o each having an inner diameter of 1 to 2 mm are formed in straight line along the longitudinal direction of the plasma-generating zone P. The plasma-generating zone P has a square cross-section normal to the longitudinal direction having a side of 2 to 5 mm. Each of the surfaces of the electrodes 2a, 2b facing each other has a plurality of recesses (hollow portions). An elevated voltage of about 9 kV obtained from a commercial AC voltage (60 Hz, 100 V) was applied to the electrodes 2a, 2b, to thereby supply a current of 20 mA. When argon gas was supplied through the gas inlet 11i, even in the case where the electrodes 2a, 2b were separated at a spacing of 4 cm, stable linear electric discharge was observed.
US08961885B2 Device for the purification of polluted waste gas
A device for the purification of polluted waste gas by means of regenerative thermal oxidation. The device has at least two heat-accumulator towers having a common combustion chamber and each containing a heat-accumulator material, the upper ends of which face the combustion chamber. The heat-accumulator towers are each connected via a control chamber to a channel for the supply of the raw gas to be purified and a channel for the discharge of clean gas. The two channels are each connectable to the at least two heat-accumulator towers via the control chambers for an alternating supply of raw gas and discharge of clean gas via shut-off devices actuable by actuators. The two channels are arranged laterally adjacent to the heat-accumulator towers and are located adjacent each other and above the respective control chambers and interconnected with the respective control chambers through openings therebetween, with the openings being closable via shut-off devices.
US08961884B2 Electric heating catalyst
The electricity is suppressed from flowing through a case (5) of an electric heating catalyst (1). The electric heating catalyst (1) comprises a heat generating element (3) which generates heat by applying electricity; a case (5) which accommodates the heat generating element (3); an inner tube (4) which is provided between the heat generating element (3) and the case (5); and a mat (6) which is provided between the heat generating element (3) and the inner tube (4) and between the inner tube (4) and the case (5) and which insulates the electricity; wherein the inner tube (4) protrudes from the mat (6) toward an upstream side and a downstream side in a flow direction of an exhaust gas, the inner tube (4) is composed of at least two substances having different thermal conductivities, the substance (42) having the lower thermal conductivity is arranged on an inner side as compared with a surface, and the substance (41) having the higher thermal conductivity is arranged to surround the substance having the lower thermal conductivity.
US08961881B2 Multi-stage catalytic air purification system
Apparatus and methods for the production of a secure supply of breathable air are important under conditions where threats from chemical and biological weapons may be present. A method and a multi-stage CATOX system for producing a purified air flow from ambient air which may have nitrogen containing toxicants is provided. The multi-stage CATOX system has a first stage and second stage, at least one of the first or the second stage has a first catalytic heat exchanger with a cold side supporting a first catalyst and a hot side configured to transfer heat therefrom to the first catalyst.
US08961878B2 Label-free cellular manipulation and sorting via biocompatible ferrofluids
A device for separating a sample of cells suspended in a bio-compatible ferrofluid is described. The device includes a microfluidic channel having a sample inlet, at least one outlet and a length between the same inlet and the at least one outlet, wherein a sample can be added to the sample inlet and flow along the microfluidic channel length to the at least one outlet. The device includes a plurality of electrodes and a power source for applying a current to the plurality of electrodes to create a magnetic field pattern along the microfluidic channel length. The present invention also includes a method of using said device for separating at least one cell type.
US08961877B2 High-throughput, whole-animal screening system
Distinctive components that enable high-throughput, whole-animal screening are described. These components can be used individually or in various combinations. A staging chip strains off the excess fluid that the input animals are immersed in, increasing their density (number of animals in a given volume) and rapidly bringing them close to other fluidic components. A microfluidic sorter is adapted to isolate and immobilize a single, physiologically active animal in a selected geometry. A multiplexed micro-chamber chip receives single animals and the microchamber chip includes individually addressable screening chambers for imaging, incubation and exposure of individual animals to selected chemical compounds. An imaging structure generates sub-cellular, high-resolution images of the physiologically active animals. A well-plate interface chip is used to deliver elements from a compound library to a single output of the chip.
US08961876B2 Sample analyzer
A sample analyzer for analyzing a sample with a liquid in a container is disclosed. The sample analyzer comprises: a reader that reads an information of a liquid in a container, the information of the liquid being stored in a storage medium; a display; and a controller including a processor and a memory under control of the processor, the memory storing instruction causing the processor to carry out operations comprising: determining whether the sample analyzer is ready to read the information of the liquid by the reader; and causing, when the sample analyzer is determined to be ready, the display to display an indication that indicates the sample analyzer is ready to read the information of the liquid by the reader.
US08961873B2 Antinfection protecting healthcare workers to prevent spreading of communicable and nosocomial infections
The present invention describes a new system and method, named “Antinfection”, to protect primarily healthcare workers (HCWs) and patients against communicable and nosocomial infections. It's based on new antiseptic sprays, non-alcoholic, that can be sprayed automatically on the hands. The base of the antiseptic action is the persistent part, preventing the colonization of tissue and non-living surfaces with microorganisms through the targeted, on-demand release of Fluorine ions. The system including new sprayers for fast and controlled application; new technologies to secure the long-term protection against wear in the daily work routines of HCWs; new measurement techniques for the quality of the Antinfection; new quality recording concepts for the promotion and verification of new strategies and campaigns in the “lost war against the germs”.
US08961871B2 Apparatus for the sterilization of plastics material containers by means of medium-controlled electron beams
An apparatus for sterilization of an inner wall of containers has a charge carrier source for generating charge carriers, with an acceleration device by which charge carriers are capable of being accelerated in the direction of a charge carrier emission window. The charge carrier emission window is arranged on a treatment device for introduction through an opening into the container along an insertion direction, in order to act upon an inner wall of the container with the charge carriers issuing from the charge carrier emission window. A medium is flowed into the region of the charge carriers issuing out of the charge carrier emission window for changing the dimension of a charge carrier cloud formed by the discharged charge carriers.
US08961870B2 Aluminium lithographic sheet
The invention relates to an aluminum alloy lithographic sheet product having an enhanced electrolytic graining response in which Zn between 0.5 and 2.5 wt % is added to an aluminum base alloy, in particular an alloy of the 1XXX, 3XXX or 5XXX series alloys. The invention also relates to a method of producing a lithographic sheet product.
US08961869B2 Hardfacing alloy
A hardfacing alloy for use as a surfacing on metal that are subjected to high thermal and mechanical stresses. The hardfacing alloy includes at least about 7 weight percent chromium, at least about 0.02 weight percent nitrogen, metal sensitization inhibitor, and a majority weight percent iron. The hardfacing alloy includes a low percentage of ferrite.
US08961863B2 Heap leaching aeration system
An aeration system for a bed of ore that is laid upon a basal layer has a gas source located upstream for supplying gas and aeration pipes that distribute the gas downstream to the bed. Each aeration pipe has spaced-apart gas emitters that distribute gas to the bed and the aeration pipes extend through the bed towards the basal layer.
US08961861B2 Mold clamp opening/closing device
A device and method for moving a mold clamp assembly of a molding apparatus between and open and closed position when the molding apparatus is in a stationary position. The device includes a rotatable cam member. A first cam surface is provided on the rotatable cam member. The first cam surface cooperates with a cam follower of the mold clamp assembly to move the mold clamp assembly to the open position when the rotatable cam member is rotated. A second cam surface is also provided on the rotatable cam member. The second cam surface cooperates with the cam follower of the mold clamp assembly to move the mold clamp assembly from the open position to the closed position when the rotatable cam member is further rotated.
US08961860B2 Laser build up method using vibration and apparatus
A laser built up method on an object with different surfaces is provided. The object can be coated locally, which is not possible by the conventional rapid prototyping processes. The object is put into a powder bed, powder is provided on or near the object and the powder is only locally provided on the upper outer surface of the object and then densified.
US08961854B2 Urisheath with moulded unrolling strip
The urisheath provided here includes an element of thin material (a strip) that allows at least two lengths of it to run in a parallel fashion down either side of the sheath. The is obtained by injection molding the strip in liquid silicone in the silicone injection molding process for the urisheath, either by one, two or more component injection molding. The injection molding takes place in an injection molding form for a urisheath with a cavity for the body portion and a cavity for the strip portion wherein the cavity for the body portion is connected to the cavity for the strip portion creating an attachment zone between the strip and the sheath.
US08961850B2 Method of making a structured surface and article therefrom
A method of making a structured surface is disclosed. The method includes providing a thermoplastic backing with multiple rows of upstanding elements. The upstanding elements include stems with proximal ends attached to the thermoplastic backing and distal caps, and each distal cap has an overhanging portion that extends beyond the stem in a first direction. For at least some of the multiple rows, an implement is passed between two adjacent rows, wherein the implement contacts the overhanging portion of at least some of the distal caps in the two adjacent rows such that at least part of the overhanging portion is turned in a second direction, different from the first direction. A structured surface that can be prepared by the method is also provided along with a fastening laminate that includes a carrier and the structured surface and an absorbent article that includes the fastening laminate. A tool useful for carrying out the method is also provided.
US08961848B2 Methods for increasing a retention force between a polymeric scaffold and a delivery balloon
A medical device-includes a scaffold crimped to a catheter having an expansion balloon. The scaffold is crimped to the balloon by a process that includes inflating the delivery balloon during a diameter reduction to improve scaffold retention and maintaining an inflated balloon during the diameter reduction and prior and subsequent dwell periods.
US08961842B2 Device for regulating deformations of the bed of a geometrically aerodynamic mold and molding method with this device
The invention describes a regulating device that adapts to the aerodynamic profile of a mold bed made of composite material offsetting the geometrical deviations occurring in the mold bed. The device comprises some stiffening ribs (20) supported on a surface of the bed (10) of the mold and is equipped with actuators (21) that modify the curvature of the bed (10) of the mold.
US08961839B2 Production method of optical waveguide
A production method of an optical waveguide includes: preparing a laminated body that includes a first clad layer and at least a core layer laminated on the first clad layer; forming a light propagating optical waveguide core by cutting the core layer by use of a dicing saw from a side where the core layer is laminated while intruding an edge of a blade portion of the dicing saw into the first clad layer so as to partially cut the first clad layer; and embedding at least a cut portion of the laminated body with a second clad layer.
US08961835B2 Conductive metal ink composition and method for forming a conductive pattern
The present invention relates to a conductive metal ink composition which is properly applied for roll-printing process to form conductive pattern with improved conductivity, and the method of preparing a conductive pattern using the same.The conductive metal ink composition comprises a conductive metal powder; an organic silver complex where an organic ligand including amine group and hydroxyl group binds with a silver (Ag) salt of aliphatic carboxylic acid; a non-aqueous solvent comprising a first non-aqueous solvent having a vapor pressure of 3 torr or lower at 25° C. and a second non-aqueous solvent having a vapor pressure of higher than 3 torr at 25° C.; and a coatability improving polymer.
US08961830B2 Electroactive polymers containing pendant pi-interacting/binding substituents, their carbon nanotube composites, and processes to form the same
A composition of matter comprises a polymer with a fully conjugated backbone or a conjugated block with a plurality of binding groups connected to the backbone by a linking moiety. The binding groups permit a non-covalent binding to a graphitic surface such as a carbon nanotube. A composition of matter where an electroactive polymer with binding groups connected to a conjugated backbone through a linking moiety is bound to carbon nanotubes. Such compositions can be used for a variety of applications using electroactive materials.
US08961825B2 Fluorescent silica nanoparticles through silica densification
Provided herein are core-shell silica nanoparticles with a dense silica shell. The nanoparticles have improved properties such as, for example, increased photo luminescence and stability. Also provided are methods for making the nanoparticles.
US08961821B2 Gas stream treatment process
A process of treating a gas stream containing mercury and acid gas pollutants is disclosed. The process includes applying a sorbent composition into a gas stream in order to adsorb mercury containing compounds and acid gas pollutants. The sorbent composition includes a compound having the formula (SiO2)x(OH)yMzSaF.B. The combination of basic inorganic solids for the adsorption of acid gases, and metal sulfide-doped silica for the adsorption of mercury provides dual sorbent functionality, along with additional benefits for each individual sorbent: silica for moisture retention on the surface of the basic inorganic particle and adsorption of acid gas, which will improve metal sulfide performance at higher operating temperatures. The use of a hygroscopic solid effectively dries the metal sulfide-doped silica slurry without the use of filtration of drying equipment, providing significant economic benefit for the manufacture of metal sulfide-doped silica material.
US08961814B2 High-selectivity wet patterning of source-drain electrodes over TAOS for a BCE device structure
Methods and formulations for the selective etching of etch stop layers deposited above metal-based semiconductor layers used in the manufacture of TFT-based display devices are presented. The formulations are based on an alkaline solution. Methods and formulations for the selective etching of molybdenum-based and/or copper-based source/drain electrode layers deposited above metal-based semiconductor layers used in the manufacture of TFT-based display devices are presented. The formulations are based on an alkaline solution.
US08961812B2 Compositions comprising Z-1,2-difluoroethylene and uses thereof
The present invention relates to compositions for use in refrigeration, air-conditioning, and heat pump systems wherein the composition comprises Z-1,2-difluoroethylene (Z-HFO-1132a). The compositions of the present invention are useful in processes for producing cooling or heat, as heat transfer fluids, foam blowing agents, aerosol propellants, and power cycle working fluids.
US08961809B2 Electrolyte synthesis for ultracapacitors
A method of forming an electrolyte solution involves combining ammonium tetrafluoroborate and spiro-bi-pyrrolidinium bromide in a liquid solvent to form spiro-bi-pyrrolidinium tetrafluoroborate and an ammonium halide. The ammonium halide precipitate is removed from the solvent to form an electrolyte solution. The reactants can be added step-wise to the solvent, and the method can include using a stoichiometric excess of the ammonium tetrafluoroborate to form a substantially halide ion-free electrolyte solution.
US08961803B1 Protection of porous substrates before treatment
A method is provided for treating a surface of a porous material in an environment, the method comprising the steps of contacting a porous material with an organic gas in an environment having a pressure P1 and a temperature T1, wherein the organic gas is such that at the pressure P1 and at the temperature T1 it remains a gas when outside of the porous material but condenses as an organic liquid when in contact with the porous material, thereby filling pores of the porous material with the organic liquid, cooling down the filled porous material to a temperature T2 such that the organic liquid freezes within the pores, thereby sealing the pores with an organic solid, thereby providing a protected porous material, and performing a treatment on the surface.
US08961802B2 Method of forming fine pattern, and developer
A method of forming a fine pattern, including: a phase separation step in which a layer containing a block copolymer having a plurality of blocks bonded is formed on a substrate, and then the layer is heated for phase separation of the layer; a decomposition step in which at least a portion of a phase of at least one block of the plurality of blocks constituting the block copolymer is decomposed; a selective removal step in which the layer is immersed in a developing solution to selectively remove a phase containing decomposed blocks to form a nano structure; and an etching step in which the substrate is subjected to etching by using the nano structure as a mask; and a main component of the developing solution is an organic solvent having an SP value of 7.5 to 11.5 (cal/cm3)1/2, and having vapor pressure of less than 2.1 kPa at 25° C., or is benzene that may be substituted by an alkyl group, an alkoxy group, or a halogen atom, and the developing solution further contains metal alkoxide.
US08961800B2 Functional nanoparticles
Functional nanoparticles may be formed using at least one nano-lithography step. In one embodiment, sacrificial material may be patterned on a multi-layer substrate using an imprint lithography system. The pattern may be further etched into the multi-layer substrate. Functional material may then be deposited on multi-layer substrate and solidified. At least a portion of the functional material may then be removed to provide a crown surface exposing pillars. Pillars may be removed from multi-layer substrate forming functional nanoparticles.
US08961799B2 Nano-structured surface
A method of forming a nano-structured substrate is provided, the method comprising including forming non-integral nano-pillars on a substrate surface and directionally etching the substrate surface using the non-integral nano-pillars as a mask to form integral nano-structures in the substrate.
US08961798B2 Method for measuring a concentration of a compound in a liquid stream
A method and system of providing ultrapure water for semiconductor fabrication operations is provided. The water is treated by utilizing a free radical scavenging system and a free radical removal system. The free radical scavenging system can utilize actinic radiation with a free radical precursor compound, such as ammonium persulfate. The free radical removal system can comprise use of a reducing agent. The ultrapure water may be further treated by utilizing ion exchange media and degasification apparatus. A control system can be utilized to regulate addition of the precursor compound, the intensity of the actinic radiation, and addition of the reducing agent to the water.
US08961797B2 Water treatment system tank selector valve assembly
A valve assembly for a twin tank-type water treatment system includes and a tank selector valve assembly that includes first and second rotary selector valves driven in concert with another by a reversible electric motor. The motor drives the first and second selector valves between (a) a first position in which an untreated water inlet and a treated water outlet of the valve assembly are coupled to a first resin tank, and a second resin tank is connected to a regeneration valve, and (b) a second position which the untreated water inlet and the treated water outlet of the valve assembly are coupled to the second resin tank, and the first resin tank is connected to a regeneration valve. The rotary valves may be disks that rotate relatively rapidly on a common shaft driven by the electric motor through an arc of 180° or less.
US08961795B2 Apparatus and method for removing impurities in connection with liquid-liquid extraction of copper
The invention relates to an apparatus and method for removing molybdenum and other possible impurities from an organic copper-containing extraction solution in connection with the liquid-liquid extraction related to copper recovery. The removal of impurities occurs in one or several removal units built into the organic extraction solution storage tank.
US08961794B2 Metal impurity and high molecular weight components removal of biomass derived biocrude
This invention relates to a process for production of transportation fuels from biomass. More particularly, this invention relates to a process for using solvent to remove metal impurities and high molecular weight components from biomass derived biocrude to prevent potential catalyst poisoning and catalyst bed plugging in biocrude-to-transportation fuel upgrading process.
US08961791B2 Molecular exchange device
The present relates to a molecular exchange device. In particular, the present invention relates to a molecular exchange device comprising an outer tube extending from an approximal end to a distal end of the device; an inner tube defining at least one fluid passageway, the inner tube positioned concentrically within the outer tube and the area between the inner and the outer tube defining at least one fluid passageway; and a projection positioned within the area between the inner and the outer tube, wherein the projection prevents displacement of the inner tube with respect to the outer tube.
US08961783B2 Apparatus and methods for preparative liquid chromatography
A method of liquid chromatography includes providing one or more solvent reservoirs, providing a solvent pump, drawing one or more solvents into the pump in response to a pressure drop that promotes outgassing of the solvents, and dispersing outgassed bubbles into smaller bubbles to promote re-dissolution of the gas. A liquid-chromatography apparatus includes at least two solvent reservoirs, a pump, at least one bubble-dispersing unit that receives a pressurized flow of proportioned solvents from the pump, and a control unit. The control unit includes a processor and a memory that stores instructions; the control unit controls proportioning of solvents to obtain a preselected solvent composition, and pumping at flow rates to support preparative-scale or process-scale liquid chromatography.
US08961782B2 Water filtering system
Grey water is conveyed to a tank, passed through filters, and pumped to an irrigation system. A floating spray component is provided in the tank to automatically backwash the filters to prevent clogging, moving up and down as the level of water in the tank changes. The filters can be cylindrical and oriented vertically, and a removable, internal filter cartridge can mount the filters. The filters can be accessed through a top, above ground cap, and the carriage can be removed for access to other parts by removing a larger lid.
US08961779B2 Reaction system and products therefrom
A reaction system and method for removing heteroatoms from oxidized-heteroatom-containing hydrocarbon streams and products derived therefrom are disclosed. An oxidized-heteroatom-containing hydrocarbon feed is reacted in a reaction system thereby forming non-ionic hydrocarbon products. The products derived therefrom are useful as transportation fuels, lubricants, refinery intermediates, or refinery feeds.
US08961778B2 Heavy feed hydroconversion method in ebullated bed mode with feed injection at the reactor top
The invention relates to a method of hydroconverting in ebullated bed mode a petroleum feed containing a significant amount of light fractions and, among other things, asphaltenes, sulfur-containing and metallic impurities.More precisely, the object of the invention is a hydroconversion method using at least one ebullated-bed reactor for which injection of the feed is carried out at the top of said reactor, in the gas overhead, and involving separation within said feed inside the reactor into a vaporized fraction and a liquid fraction.The invention also relates to the reactor allowing said method to be implemented.
US08961776B2 Molecular metal-Oxo catalysts for generating hydrogen from water
A composition of matter suitable for the generation of hydrogen from water is described, the positively charged cation of the composition having the general formula [(PY5W2)MO]2+, wherein PY5W2 is (NC5XYZ)(NC5H4)4C2W2, M is a transition metal, and W, X, Y, and Z can be H, R, a halide, CF3, or SiR3, where R can be an alkyl or aryl group. The two accompanying counter anions, in one embodiment, can be selected from the following Cl−, I−, PF6−, and CF3SO3−. In embodiments of the invention, water, such as tap water containing electrolyte or straight sea water can be subject to an electric potential of between 1.0 V and 1.4 V relative to the standard hydrogen electrode, which at pH 7 corresponds to an overpotential of 0.6 to 1.0 V, with the result being, among other things, the generation of hydrogen with an optimal turnover frequency of ca. 1.5 million mol H2/mol catalyst per h.
US08961775B2 High productivity Kolbe reaction process for transformation of fatty acids derived from plant oil and animal fat
Oils from plants and animal fats are hydrolyzed to fatty acids for a Kolbe reaction. The invention relates to a high productivity Kolbe reaction process for electrochemically decarboxylating C4-C28 fatty acids using small amounts of acetic acid to lower anodic passivation voltage and synthesizing C6-C54 hydrocarbons. The C6-C54 undergo olefin metathesis and/or hydroisomerization reaction process to synthesize heavy fuel oil, diesel fuel, kerosene fuel, lubricant base oil, and linear alpha olefin products useful as precursors for polymers, detergents, and other fine chemicals.
US08961772B2 Method and apparatus for electroplating metal parts
A supply of metal parts are electroplated by progressively transferring the parts with a computer controlled robot into a series of open top tanks containing solutions. The tanks have submerged metal fixtures which temporarily support the parts, and each fixture in the electroplating tank is individually connected to a direct current power source through a corresponding timer switch controlled by the computer so that each part is plated for a precise time period independently of the time the part remains in the plating solution. Each fixture is coated with an insulation material and has a base with metal contact with a removable fixture member having limited metal line contact with the supporting part. A plurality of electroplating lines each include the above components, and common tanks in the lines receive an electroplating solution recirculated through a common filter and service tank where the solution is heated and controlled.
US08961768B2 Metal containing integrated electrocoat for better corrosion resistance
An aqueous electrodeposition coating composition comprising (a) a metal oxide selected from the group consisting of bismuth oxide, vanadium oxide, manganese oxide, cobalt oxide, zinc oxide, strontium oxide, yttrium oxide, molybdenum oxide, zirconium oxide, lanthanum oxide, oxides of the lanthanide series of elements, and combinations of these and (b) a cathodically electrodepositable binder, the binder comprising an amine-functional phosphorylated resin, provides corrosion protection equivalent to that obtained by the conventional phosphate pretreatment-electrodeposition coating process.
US08961765B2 Plastic microfluidic separation and detection platforms
Plastic electrophoresis separation chips are provided comprising a plurality of microfluidic channels and a detection window, where the detection window comprises a thin plastic; and the detection window comprises a detection region of each microfluidic channel. Such chips can be bonded to a support provided an aperture is provided in the support to allow detection of samples in the electrophoresis chip at the thin plastic detection window. Further, methods for electrophoretically separating and detecting a plurality of samples on the plastic electrophoresis separation chip are described.
US08961764B2 Micro fluidic optic design
A DNA analyzer includes an interface for coupling a microfluidic chip to the DNA analyzer. The microfluidic chip includes a first separation channel for electrophoretic separation of DNA fragments in a first sample. Further, the DNA analyzer includes a first optical device. The first optical device includes an illuminating path and a detecting path. The illuminating path directs a first input light beam received from a light source to a first separation channel of the microfluidic chip. The first input light beam causes fluorescent labels attached on DNA fragments in the first separation channel to emit a first fluorescence light. The detecting path collects and directs the first fluorescent light to a first plurality of optical fibers. Further, the DNA analyzer includes a spectrometer configured to receive the first fluorescent light from the plurality of optical fibers and detect fluorescent components in the first fluorescent light.
US08961761B2 Oxygen sensor control apparatus
An oxygen sensor control apparatus includes internal resistance detection means S3, controlled internal resistance obtaining means S4 to S11, and heater energization control means S12. When a timing for detecting the internal resistance R(n) comes during a lean period TL, the controlled internal resistance obtaining means uses the detected internal resistance R(n) as the controlled internal resistance Rf. When a timing for detecting the internal resistance R(n) comes during a rich period TR, the controlled internal resistance obtaining means uses, as the controlled internal resistance Rf, a value obtained by correcting the detected internal resistance R(n) on the basis of a latest lean resistance R(k) such that a variation of the internal resistance which stems from the difference between the lean state and the rich state and which is contained in the detected internal resistance R(n) is removed.
US08961760B2 Micromechanical solid-electrolyte sensor device and corresponding production method
A micromechanical solid-electrolyte sensor device includes a micromechanical carrier substrate having a front side and a back side. The micromechanical solid-electrolyte sensor device also includes a first porous electrode and a second porous electrode. The micromechanical solid-electrolyte sensor device also includes a solid-electrolyte embedded between the first porous electrode and the second porous electrode.
US08961755B2 Semiconductor wafer holder and electroplating system for plating a semiconductor wafer
A semiconductor wafer holder includes first and second holding members between which a semiconductor wafer is held. The second holding member includes a second conductive element placed in contact with a first conductive element of the first holding member and the semiconductor wafer. A ring clamp is used to press the second holding member against the first holding member for holding of the semiconductor wafer.
US08961750B2 Electrochemical modular cell for processing electrolyte solutions
The invention relates to the production of different chemical products by the electrochemical processing of electrolyte solutions of different concentrations. A cylindrical electrochemical cell for processing solutions comprises an inner, hollow, tubular anode, an outer, cylindrical cathode, and a permeable, tubular, ceramic diaphragm that is arranged between said anode and cathode and divides the interelectrode space into anode and cathode chambers so that a working section of the cell is formed. The cell comprises units for mounting, securing and sealing the electrodes and the diaphragm, which are located at the end sections of the cell, and devices for supplying and removing the processed solutions. The cathode and anode of the cell are made of titanium tubes; furthermore, the ratio of the cross-sectional area of the cathode chamber to the total cross-sectional area of the anode chamber and the diaphragm ranges from 0.9 to 1.0, and the length of the working section of the cell is 15-25 times the outside diameter of the anode. The invention makes it possible to preserve the stability of the hydrodynamic characteristics of the electrode chambers and the electric field characteristics, intensify the electrolysis process and extend the cell functionalities.
US08961748B2 Water electrolysis system
A water electrolysis system includes a water electrolysis apparatus, a low-pressure gas-liquid separator, a high-pressure gas-liquid separator, water pipe, and a decompression water supply device. The high-pressure gas-liquid separator separates the hydrogen received from a cathode of the water electrolysis apparatus and permeation water that has permeated from the anode. The water pipe connects the high-pressure gas-liquid separator and the low-pressure gas-liquid separator and is used for returning the water from the high-pressure gas-liquid separator to the low-pressure gas-liquid separator. The decompression water supply device is arranged at the water pipe and is to decompress the water discharged from the high-pressure gas-liquid separator.
US08961744B2 System and method for recycling high-boiling-point waste photoresist stripper
In a system and method for recycling a high-boiling-point waste photoresist stripper generated in processes of manufacturing LCDs or semiconductor devices, an expensive high-boiling-point stripper solvent can be easily recycled at high yield and high-purity electronic grade. This system includes a first distillation device for removing low-boiling-point impurities, a second distillation device for recycling a stripper solvent composition while removing high-boiling-point impurities, and a third distillation device for removing trace water, thus recovering the stripper solvent composition, and further includes a fourth distillation device for additionally recycling a stripper solvent, thus additionally recovering a high-boiling-point stripper solvent, and this method includes removing low-boiling-point impurities, recycling a stripper solvent composition while removing high-boiling-point impurities, and removing trace water, thus recovering the stripper solvent composition, and further includes additionally recycling a stripper solvent.
US08961741B2 Device for retaining doctor blades
A device for retaining doctor blades includes a support element and a retaining finger with a doctor blade pocket inserted between the support element and the retaining finger. The support element and the retaining finger are constructed as a single piece.
US08961736B2 Plasma reactor with internal transformer
There is provided a plasma reactor with an internal transformer. The plasma reactor comprises: a plasma chamber with a gas inlet and a gas outlet, for providing a plasma discharging space; one or more core cylinder jackets for providing a core storage space in the plasma discharging space and forming a plasma centralized channel and a plasma decentralized channel by including one or more through-apertures; and one or more transformers each including a magnetic core with primary winding surrounding the through-aperture and installed in the core storage space, wherein the plasma discharging space comprises one or more first spatial regions to form the plasma centralized channel and one or more second spatial regions to form the plasma decentralized channel. In the plasma reactor, since the transformer is installed in the plasma chamber, energy is transferred with almost no loss from the transformer to the plasma discharging space and therefore the energy transfer efficiency is very high. Then, since most of gases flow through the first spatial region and the through-aperture inside the plasma chamber, most of active gases are generated in the plasma centralized channel. Consequently, the plasma reactor is very suitable for generating large amount of active gases. Further, even though the plasma chamber is composed of a conductive material, since no special insulating region needs to be formed, it is very easy to constitute the plasma chamber. Further, since the plasma chamber itself is sufficiently capable of forming an outer case, the plasma reactor is very simply manufactured.
US08961731B2 Manufacturing method of three-dimensional display device
In a three-dimensional image display device using a liquid crystal parallax barrier panel, a liquid crystal display panel is first roughly aligned with the liquid crystal parallax barrier panel using an alignment mark. Subsequently, a white pattern for two pixels is formed in the center of a screen. When an observer's eyes are brought close to the screen, a blue pattern is generated in the center, and a white pattern is generated on both sides of the blue pattern. The relationship between a width d1 of the blue pattern and a width d2 of the white pattern is d1=2d2, and the tilt of the blue pattern is set in a predetermined range, so that necessary alignment accuracy can be secured.
US08961729B2 Method for manufacturing touch panel
A method of manufacturing a touch panel is disclosed. The method includes providing a plurality of substrates, each having a size, providing a carrier including a plurality of grooves each having a size corresponding with the size of the substrates. The method also includes placing the plurality of substrates into the grooves, simultaneously forming a touch structure layer on each of the substrates, and separating substrates from the carrier.
US08961728B2 Film attaching apparatus and film attaching method using the same
Film attaching apparatus and process for attaching the film by preparing a mother panel comprising a first panel, a second panel, and a third panel; preparing a first and a second set tables that are independently driven from each other on a moving path of the mother panel; preparing a first film that is to be attached to the first panel on the first set table; driving the first set table to attach the first film to the first panel; preparing a second film that is to be attached to the second panel on the second set table; driving the second set table to attach the second film to the second panel; preparing a third film that is to be attached to the third panel on the first set table; and driving the first set table to attach the third film to the third panel.
US08961726B2 Method for infiltrating silicone into a fiber composite structure and device for executing a method for producing a fiber composite workpiece
The invention relates to a method for producing a fiber composite workpiece. In the method according to the invention, cross-linking silicone is used with the aid of a volatile diluent for infiltrating individual mats of a mat composite. A further object of the present invention is a device for performing the method according to the invention.
US08961723B2 Method of customizing an article and apparatus including an inflatable member
A graphic transfer assembly is disclosed. The graphic transfer assembly includes an inflatable member that is capable of expanding to fill the interior of an article of footwear. The graphic transfer assembly can include a fluid pump for filling the inflatable member.
US08961721B2 Core intended to be used as a support for a roll of paper
A core intended to be used as a support for a roll of paper, especially toilet paper, is formed by winding at least one strip made of tissue, the strip being impregnated, at least locally, with starch so as to improve its stiffness. Thus configured, a core is provided having both a mechanical strength suitable for the envisaged use and a greatly improved ability to disintegrate relative to a cardboard core so as to allow it to be able to be disposed of directly in a toilet bowl without risk of blocking the soil pipe.
US08961718B2 Apparatus and method for laminating anisotropic conductive film on flat display panel
The present invention provides an apparatus and a method for laminating an anisotropic conductive film on a flat display panel. The apparatus includes: a feeding device, a cutting device, a pressing device, and a collection device. The feeding device supplies an anisotropic conductive film. The anisotropic conductive film includes a film body and a release sheet laminated on the film body. The cutting device includes an ultrasonic cutter, which is arranged under the feeding device to cut off the film body of the anisotropic conductive film passing therethrough. The pressing device is arranged at one side of the cutting device to attach the film body of the anisotropic conductive film that has been cut off and is ready to laminate to the flat display panel. The collection device is arranged at one side of the pressing device that is away from the cutting device to collect the release sheet of the anisotropic conductive film. The present invention uses an ultrasonic cutter to cut off the anisotropic conductive film in a non-contact manner so as to provide high cutting preciseness and effectively eliminate the occurrence of poor lamination of the anisotropic conductive film resulting from blunting of cutter and attaching of residual adhesive of the anisotropic conductive film to the cutter.
US08961706B2 Dishwashing machine and method for operating the same
A dishwashing machine equipped with a washing compartment and with devices for washing dishes using a washing solution also includes a sorption drying device which is connected to the washing compartment in an air-conducting manner and which comprises a sorption column containing reversibly dehydratable material, this sorption column being used for drying the dishes. To this end, the sorption drying device comprises a sensor that, during the executing of a washing program, serves to detect the state of the reversibly dehydratable material in order to influence the execution of the washing program according to the detected state.
US08961704B2 Dishwasher
A dishwasher includes a washing container having a washing chamber, a water feed line for filling the washing chamber with liquid, and a water inlet device connected on an inlet side to the water feed line and ending in the washing chamber on an outlet side. The water inlet device includes a steam outlet opening that ducts water vapor out of the washing container. The water inlet device prevents a negative-pressure-induced reversal of flow against the filling direction in the water feed line.
US08961701B2 Method and system of drying a microelectronic topography
Drying a microelectronic topography. At least some of the illustrative embodiments are methods that include placing a microelectronic topography inside a process chamber, providing a non-aqueous liquid to the process chamber until at least 90% of the volume of the process chamber contains the non-aqueous liquid, pressurizing the process chamber by way of a fluid different than the non-aqueous liquid, ceasing activity with respect to the process chamber until the non-aqueous liquid and fluid form a mixture that is substantially homogenous, venting the process chamber while simultaneously providing the fluid to the process chamber, and venting the process chamber in a manner which prevents formation of liquid in the process chamber.
US08961690B2 Tooling carrier for inline coating machine, method of operating thereof and process of coating a substrate
A process of coating at least one substrate with a plurality of deposition sources, a method of tooling, a carrier unit and a deposition system are described. The systems and methods provide for or allow for exposing a first substrate portion 112a of said at least one substrate 112 to a first deposition source 118a through an aperture 122 of a carrier unit 110, 510, depositing a first layer 126a over the first substrate portion, said first layer including material from said first deposition source, varying a relative position between said at least one substrate and said aperture for exposing a second substrate portion of said at least one substrate, or another substrate, to a second deposition source, and depositing a second layer 126b over the second substrate portion 112b, said second layer including material from said second deposition source.
US08961688B2 Method and device for plasma treating workpieces
Disclosed are a method and a device for plasma treating workpieces (5). Said workpiece is inserted into a chamber (7) of a treatment station (3), which can be at least partly evacuated, and is positioned within the treatment station by means of a holding element. In order to simultaneously supply at least two chambers with at least one operating means, a flow of the operating means is branched at least once so as to form at least two partial flows (55).
US08961680B2 Solvent formulations
The present disclosure provides, in part, a solvent composition including an an acetic acid alkyl (C1-C4) ester (e.g., methyl acetate (MA), ethyl acetate (EA), or tert-butyl acetate (TBAc)) and a carbonate ester (e.g., dimethyl carbonate, or propylene carbonate).
US08961677B2 Suspension of nanoparticles and method for making the same
A stable suspension of ethylpolysilicate nanoparticles having a size of between about 5 nm and 120 nm are in water and stabilized with between about 0.05 and 5 weight percent tetraalkylammonium hydroxide. The particles are between about 95% and 99.5% hydrolyzed and have superior removal rates when used in chemical mechanical polishing. A process for making ethylpolysilicate nanoparticles includes the step of adding reverse osmosis water and 25% tetramethylammonium hydroxide and ammonium hydroxide to a reactor, agitating the mixture and heating the mixture to about 80° C. Tetraethylalkoxy silane is added to the mixture and the mixture stirred and hydrolyzed. Ethanol is then removed. The mixture was then subjected to a vacuum to remove additional distillate. The material left in the reactor was then transferred to a plastic drum.
US08961672B2 Organosiliconate powders, method for the production thereof and use thereof for hydrophobizing mineral building materials
Solid alkali metal salts of organosilanols and/or their hydrolysis/condensation products are prepared by hydrolysis of organosilanes in water and in the presence of a basic alkali metal salt. The products contain predominately methyl and ethyl organic groups, and C4 or higher hydrocarbon groups as well. The solid salts effectively hydrophobe building materials, while being easily mixed with water.
US08961664B2 Carbon dioxide recovery device
A carbon dioxide recovery unit is provided with: an absorption tower for bringing an exhaust gas into contact with a CO2 absorbing liquid to thereby absorb and recover CO2 from the exhaust gas; a regeneration tower for taking out the CO2 from the CO2 absorbing liquid; a CO2 delivery line L3 for delivering the taken-out CO2 to a storage process; and a CO2 return line L5 for returning the taken-out CO2 to the absorption tower. When a CO2 recovery unit and a CO2 compressing device are activated, if a storage process side has some kind of trouble and cannot receive the CO2, a destination part to which the CO2 is delivered from the regeneration tower is switched from the CO2 delivery line L3 to the CO2 return line L5, whereby the CO2 gas is mixed with the exhaust gas in the absorption tower.
US08961662B2 Separator assembly
A separator assembly comprises a vertical vessel including a fluid inlet for receiving a fluid including a gas, at least two liquids, and solids, at least two liquid outlets for discharging the liquids, a gas outlet at an upper end thereof for discharging gas, and a solids outlet at a lower end thereof for discharging solids. A baffle plate extends across the vessel, and cooperates with the vessel to define an upper section and a lower section, and has a first conduit extending downwardly so that liquids and solids may flow into the lower section, and a second conduit extending upwardly so that gases may flow from the lower section to the upper section. A backpressure valve is in fluid communication with the gas outlet and is configured to discharge gas while maintaining a selected level of pressure inside the vessel.
US08961660B2 Canister arrangement structure, fuel vapor recovery device, and vehicle equipped with fuel vapor recovery device
A canister arrangement structure in a fuel vapor recovery device includes a canister that has built therein an adsorbent for adsorbing fuel and temporarily collects fuel vapor generated in a fuel tank of an internal combustion engine, the canister is arranged between an exhaust pipe of the internal combustion engine and the fuel tank.
US08961654B2 Reduction of mercury emissions from cement plants
This invention provides methods for reducing emissions of mercury from a cement plant comprising at least a kiln (6), a particulate collection device (10), collected particulates, an exhaust gas stream (8b), a heater, and a mercury scrubber, wherein the heater and mercury scrubber are upstream from the kiln. The methods comprise directing the collected particulates through the heater, to form volatilized mercury species from the collected particulates; directing the collected particulates from the heater downstream toward the kiln; and directing the volatilized mercury species to the mercury scrubber. The exhaust gas stream (8c) exits the particulate collection device and is not directed into the heater. Optional steps include injecting a mercury sorbent at one or more points between the kiln and the particulate collection device.
US08961653B2 Method and device for vacuum pressure swing adsorption with temporary storage
Adsorptive decomposition of a gas mixture is performed by vacuum pressure swing adsorption. The gas mixture is condensed to the adsorption pressure by means of at least one condenser prior to being fed into the vacuum pressure swing adsorption process. Regeneration of the adsorber(s) is carried out by means of at least one vacuum pump. The condensed gas mixture (1, 5, 6) is at least periodically and/or at least partially temporarily stored (S1) and/or fed to a consumer at those times when no gas mixture is being fed to the vacuum pressure swing adsorption process; and/or at least one of the vacuum pumps (P) that is not required for the regeneration is used at least occasionally for another application at those times when no regeneration of the adsorber or an adsorber (A, A′) is being carried out.
US08961649B2 System and method for extracting base metal values from oxide ores
A method for recovering base metal values from oxide ore is provided by the present disclosure. The ore includes a first metal selected from the group consisting at least one of iron and aluminum and a second metal selected from the group consisting of at least one of nickel, cobalt and copper. The method includes the steps of: contacting the oxide ore with hydrogen chloride gas to obtain chlorides of the first and second metals and subjecting at least the first and second metals to pyrohydrolysis at a predetermined temperature to decompose the chlorides of the first metal into oxides. The method also includes the step of mixing the oxides of the first metal and the chlorides of the second metal in an aqueous solution to dissolve the chlorides of the second metal and recovering the dissolved ions of the second metal from the aqueous solution.
US08961648B2 Integrated steel plant with production of hot or cold DRI
An integrated steelmaking plant for merging continuous operation of a reduction reactor producing hot DRI with the batch operation of a DRI melting furnace(s). The reactor produces hot DRI for a DRI melting furnace or cold DRI continuously even when the DRI production exceeds the DRI consumption rate of the furnace or suffers long-term operational delays. The reduction reactor has a DRI cooling zone therein which is selectively operable for cooling DRI when the hot DRI produced in the reactor can't all be consumed by the DRI melting furnace and when the capacity of the DRI bin feeding the melting furnace is insufficient to accumulate additional hot DRI. No separate DRI cooling vessel plus its gas compressor and gas cooling-cleaning system is needed, thus decreasing capital and operational costs. This also permits a flexible and modular construction and operation of a steelmaking plant with high or low pressure reduction reactors.
US08961646B2 Nickel alloy
There is provided a nickel alloy having an excellent creep strength as well as high-temperature oxidation resistance. The nickel alloy of the present invention comprises, by mass percent, Cr in a range of 11.5 to 11.9%, Co in a range of 25 to 29%, Mo in a range of 3.4 to 3.7%, W in a range of 1.9 to 2.1%, Ti in a range of 3.9 to 4.4%, Al in a range of 2.9 to 3.2%, C in a range of 0.02 to 0.03%, B in a range of 0.01 to 0.03%, Zr in a range of 0.04 to 0.06%, Ta in a range of 2.1 to 2.2%, Hf in a range of 0.3 to 0.4%, and Nb in a range of 0.5 to 0.8%, the balance being Ni and unavoidable impurities, and contains carbides and borides precipitating in crystal grains and at grain boundaries.
US08961643B2 Fluid filter, in particular for petrochemical plant gas
A filter for filtering fluids, in particular gas in petrochemical plants, has: a tubular cartridge which extends along a first axis, is designed to filter a fluid, and has a first and second annular end; a casing, which is connectable to a conduit of a petrochemical plant, houses the tubular cartridge, and has a first and second end support; and an axial compensating ring located between the tubular cartridge and the first or second end support.
US08961641B2 Inertial gas-liquid impactor separator with flow director
An inertial gas-liquid impactor separator includes flow director guidance structure directing and guiding flow through the housing from the inlet to the outlet along a flow path from upstream to downstream. The flow director guidance structure may include a flow controller controlling and directing flow.
US08961640B2 Filter
This filter is used for purifying air by removing foreign matters such as liquid droplets contained in the air. A separation unit is formed by a primary port, a port block to which a secondary port is formed, and a separation cylinder attached to the port block. Inside a swirl flow generating chamber of the separation unit, a cylinder blade portion formed by arranging a plurality of blades, which are extended in an axial direction along an inner peripheral surface and also inclined in a circumferential direction, in a cylindrical form is provided. The air flowed into the swirl flow generating chamber is caused to be a swirl flow by the cylindrical blade portion and foreign matters such as liquid droplets are discharged toward a collection container in a separation chamber. The purified air is guided from a discharge pipe to the secondary port.
US08961636B2 Oil separator
The present oil separator is an oil separator for capturing oil contained in blow-by gas generated in an engine, and includes a housing provided independently of a body of the engine and a gas-liquid separation unit which is provided in the housing and separates blow-by gas into a gas component and an oil component. The housing includes a lead-in port through which the blow-by gas is led in, a lead-out port through which the gas component is led out, and a drain port through which the oil component is discharged. And the housing has an attachment portion inside to which a plurality of types of the gas-liquid separation units respectively are attachable, to which attachment portion, selected one of the plurality of types of gas-liquid separation units is attached.
US08961635B2 Device for the purification of particle-laden gases
The present invention pertains to a device for cleaning gases containing particles with a bellows and with at least one filter element arranged in the bellows. To ensure effective filtration without limitation of the mobility of the bellows, the present invention provides for at least one filter element to be fixed at a bellows inner flange of a bellows corrugation in a positive-locking manner.
US08961631B2 Process for production of dispersion of fluorinated nano diamond
There is provided a process for producing a fluorinated nanodiamond dispersion liquid, including a purification step of mixing a fluorinated nanodiamond with an alcohol having a carbon number of 4 or fewer, then conducting an ultrasonic treatment to produce a suspension, and subjecting the obtained suspension to a classification treatment by centrifugation to produce a dispersion liquid of fluorinated nanodiamond; a drying step to prepare a dry fluorinated nanodiamond by removing the alcohol from the dispersion liquid of fluorinated nanodiamond that is obtained by the purification step; and a redispersion step to prepare the fluorinated nanodiamond dispersion liquid by mixing the dry fluorinated nanodiamond that is obtained by the drying step, with an aprotic polar solvent and then conducting an ultrasonic treatment.
US08961630B2 Methods of forming cutting elements by removing metal from interstitial spaces in polycrystalline diamond
Methods of forming a cutting element include immersing at least a portion of a volume of polycrystalline diamond in a liquid electrolytic solution, applying a voltage between the polycrystalline diamond and a cathode in contact with the liquid electrolytic solution, and removing at least a portion of metal catalyst from interstitial spaces between adjacent diamond grains. The polycrystalline diamond includes interbonded diamond grains and metal catalyst particles in the interstitial spaces between adjacent grains of polycrystalline diamond material. Some methods include forming a barrier over a portion of a volume of polycrystalline diamond and transferring at least a portion of the metal catalyst from a portion of the polycrystalline diamond not covered by the barrier to a liquid electrolyte. Some methods include encapsulating a volume of polycrystalline diamond in a barrier and selectively removing a portion of the barrier from a first portion of the volume of polycrystalline diamond.
US08961628B2 Pretreatment of biomass using steam explosion methods
An integrated plant that includes a steam explosion process unit and biomass gasifier to generate syngas from biomass. A steam explosion process unit applies a combination of heat, pressure, and moisture to the biomass to make the biomass into a moist fine particle form. The steam explosion process unit applies steam with a high pressure to heat and pressurize any gases and fluids present inside the biomass to internally blow apart the bulk structure of the biomass via a rapid depressurization of the biomass with the increased moisture content. Those produced moist fine particles of biomass are subsequently fed to a feed section of the biomass gasifier, which reacts the biomass particles in a rapid biomass gasification reaction to produce syngas components.
US08961625B2 Catalytic microchannel reformer
An apparatus and method for enhancing the yield and purity of hydrogen when reforming hydrocarbons is disclosed in one embodiment of the invention as including receiving a hydrocarbon feedstock fuel (e.g., methane, vaporized methanol, natural gas, vaporized diesel, etc.) and steam at a reaction zone and reacting the hydrocarbon feedstock fuel and steam in the presence of a catalyst to produce hydrogen gas. The hydrogen gas is selectively removed from the reaction zone while the reaction is occurring by selectively diffusing the hydrogen gas through a porous ceramic membrane. The selective removal of hydrogen changes the equilibrium of the reaction and increases the amount of hydrogen that is extracted from the hydrocarbon feedstock fuel.
US08961622B2 Additives for improving the cold properties of fuel oils
The invention thus provides terpolymers of ethylene, at least one ethylenically unsaturated ester and propene, which have i) from 4.0 to 12.0 mol % of structural units derived from at least one ethylenically unsaturated ester having a C4- to C20-alkyl radical, ii) from 0.5 to 4.0 methyl groups derived from propene per 100 aliphatic carbon atoms, and iii) fewer than 8.0 methyl groups stemming from chain ends per 100 CH2 groups.
US08961616B2 Medical implant
A medical implant is disclosed, said implant having a flexible hollow body (1) which can be implanted inside the stomach (8) of a patient and which has a first tube-like end section (2) and a second tube-like end section (3), wherein the first tube-like end section (2) is dimensioned such that it can be fitted into the esophagus (7) of the patient, and the second tube-like end section (3) is dimensioned such that it can be connected to the small intestine loop (9) of the patent in a sealing manner.
US08961615B2 Bone prosthesis for maintaining joint operation in complex joints
A prosthesis for reconstructing a multibone joint such as a wrist. A patient's scaphoid is removed to create a void. The scaphoid has a plurality of adjacent bones, each of the adjacent bones comprising a surface generally facing the void. The surface of at least two of the adjacent bones is prepared by affixing a magnetic element thereto and a magnetic scaphoid implant is inserted into the void. A magnetic relationship exists between the magnetic elements and the magnetic scaphoid implant.
US08961614B2 Articular surface implant and delivery system
A method is provided for delivering an implant for replacing a portion of an articular surface. The method may include forming a socket in an articulating feature that is capable of moving relative to the articular surface. An implant may be placed in the socket and the articulating feature may be moved relative to the articular surface to generally align the socket with an implant site formed in the articular surface. The implant may be transferred from the socket into the implant site.
US08961611B2 Modular glenoid prosthesis
A method for assembling a glenoid assembly. The method includes using a base having a first side and an opposing second side. The first side includes a plurality of connection features arranged in an array. The method further includes using a plurality of glenoid attachment members, wherein each of the plurality of glenoid attachment members has a locking mechanism. One of the plurality of glenoid attachment members is selected and is connected to the base by connecting the locking mechanism of the selected one of the plurality of glenoid attachment members to one of the plurality of connection features of the base.
US08961609B2 Devices for distracting tissue layers of the human spine
The present invention relates to methods of separating, supporting or both separating and supporting layers of tissue in the human spine. Such methods generally comprise inserting at least one member between layers of tissue in the human spine and changing the configuration of the member to define a support structure between the tissue layers.
US08961607B2 Combined spinal interbody and plate assemblies
A spinal implant assembly combines a spinal interbody spacer with a spine plate. The combined spacer and plate assembly provides stabilization and torsional resistance to promote fusion of adjacent vertebrae. The spacer is configured for placement within an intervertebral space between the adjacent vertebrae previously occupied by a spinal disc. The plate is configured for attachment to anterior sides of the adjacent vertebrae. Translation of the spinal plate allows it to be affixed to the vertebrae in various positions and/or allow movement post installation. In one form, the plate is defined by first and second spine plate or plate portions that are coupled to one another to allow rotation about each other. Ends of the first and second spine plates are received in/by the interbody spacer, while a pin extends through the interbody spacer to fix the first and second spine plates to the interbody spacer.
US08961606B2 Multi-piece intervertebral implants
Intervertebral implants for implanting into an intervertebral space are provided. The implants can comprise one or more layers that are operably attached to one another. An implant can comprise a first layer having a first mating surface that mates with a second mating surface of a second layer. The first mating surface and the second mating surface can have features that allow them to complement each other. The implants can include one or more bore holes for receiving a fixation member. The bore holes can be horizontal, vertical or diagonal. In some cases, the bore holes will be blind bore holes.
US08961602B2 Adjustment suture markers for adjustable annuloplasty ring
An adjustable annuloplasty ring includes a body in the form of an endless loop having an internal lumen therethrough, an adjustment suture extending through at least a portion of the internal lumen, a first portion of the suture exiting the lumen through a first opening in the body and a second portion of the suture exiting the lumen through a second opening in the body, and a first adjustment marker on the first portion of the suture outside of the body. The suture may be adapted to reduce the length of the body around the loop when tightened.
US08961598B2 Set of annuloplasty devices with varying anterior-posterior ratios and related methods
Described is a set of at least two annuloplasty devices having a particular size that corresponds to an inter-trigonal or inter-commissural distance of a heart valve annulus, wherein the at least two annuloplasty devices have different anterior-posterior ratios. Also, described is a kit for annuloplasty repair of a heart valve annulus including a plurality of annuloplasty devices each comprising one of a plurality of different sizes, wherein the different sizes each correspond to a different inter-trigonal or inter-commissural distance of a heart valve annulus, and for each of the plurality of different sizes there are at least two devices each having the same size but having different anterior-posterior ratios. Additionally, a method of choosing an annuloplasty device for implantation in a valve annulus is described.
US08961594B2 Heart valve repair system
Techniques are described for use with one or more sutures. For some applications, techniques are described for fixedly-coupling two or more sutures to each other. For some applications, such techniques are used for treating a heart valve of a subject. Techniques are also described for treating a heart valve of a subject by coupling leaflets of the heart valve to a support using tissue-piercing elements. Other embodiments are also described.
US08961591B2 Polymeric, degradable drug-eluting stents and coatings
Absorbable stents and absorbable stent coatings have been developed with improved properties. These devices preferably comprise biocompatible copolymers or homopolymers of 4-hydroxybutyrate, and optionally poly-L-lactic acid and other absorbable polymers and additives. Compositions of these materials can be used to make absorbable stents that provide advantageous radial strengths, resistance to recoil and creep, can be plastically expanded on a balloon catheter, and can be deployed rapidly in vivo. Stent coatings derived from these materials provide biocompatible, uniform coatings that are ductile, and can be expanded without the coating cracking and/or delarmnating and can be used as a coating matrix for drug incorporation.
US08961590B2 Flexible helical stent having different helical regions
The present invention relates to tubular stents that are implanted within a body lumen. The stent has a cylindrical shape defining a longitudinal axis and includes a proximal helical section, a distal helical section and an intermediate ring section there between. Each of the proximal and distal helical sections has of a plurality of longitudinally oriented strut members and a plurality of circumferentially oriented hinge members connecting circumferentially adjacent strut members to form a band, the band being wrapped about the longitudinal axis in a substantially helical manner to form a plurality of helical windings, wherein the distal helical section is wound about the longitudinal axis in the opposite direction from the proximal helical section. The intermediate ring section includes a plurality of longitudinally oriented strut members and a plurality of circumferentially oriented hinge members connecting circumferentially adjacent strut members to form an endless ring.
US08961589B2 Bioabsorbable coating with tunable hydrophobicity
The present invention relates to implantable medical devices coated with polymer having tunable hydrophobicity and their use in the treatment of vascular diseases.
US08961588B2 Method of coating a stent with a release polymer for 40-O-(2-hydroxy)ethyl-rapamycin
A method of coating a stent is presented such that less than 50% of the total amount of 40-O-(2-hydroxyl)ethyl-rapamycin, or an analog or derivative thereof, is released in vivo in a 24 hour period, wherein the method comprises exposing the coating to sufficient temperature to modify the structure of the polymer.
US08961586B2 Bifurcated stent assemblies
Disclosed is a stent assembly for expanding in vivo vessels, the assembly comprising first and second radially expandable mesh stents, wherein the first stent is separated by a predetermined distance from the second stent and a stent jacket spans the predetermined distance such that a first end of the jacket is operatively associated with the first stent and a second end of the jacket is operatively associated with the second stent.
US08961585B2 Controlled fracture connections for stents
The invention provides for intra-luminal stents, especially stent having controlled fracture connection, as well as, methods of making and using the same. In one embodiment, a stent for implantation into a vessel has a plurality of annular segments collectively forming tubular shape, characterized by at least first and second adjacent annular segments each defined by a plurality of struts and at least one joint interconnecting respective struts of the first and second segments on a non-permanent basis.
US08961581B2 Delivery system having stent retention structure
A drainage stent delivery system including an elongate shaft of a medical device, a drainage catheter or stent, and an engagement member, such as a distensible member or a compressible member, for selectively coupling the stent to the elongate shaft. The engagement member is positioned between the inner surface of the stent and the outer surface of the elongate shaft and is elongatable from a first length to a second length by longitudinal movement generally parallel to the central longitudinal axis of the stent to release the stent. At the first length, the engagement member is engaged with the inner surface of the stent to secure the stent on the elongate shaft, and at the second length the engagement member is sufficiently disengaged from the inner surface of the stent to release the stent from the elongate shaft such that the elongate shaft may be withdrawn from the stent.
US08961578B2 Dermatological treatment device with one or more vertical cavity surface emitting lasers (VCSEL)
A device for providing laser-based dermatological treatments may include a device body having an application end, a VCSEL laser supported in the device body and including multiple emitter zones, each emitter zone comprising one or more micro-emitters, each micro-emitter configured to emit a micro-beam, wherein at least two of the multiple emitter zones are configured such that the micro-beam emitted by the micro-emitters of the at least two emitter zones form a combined beam through the application end of the device to provide a treatment spot on the skin, and electronics coupled to the at least two emitter zones and configured to control the at least two emitter zones independently.
US08961577B2 Correction of female urinary incontinence and skin reduction
The invention relates to devices and compositions useful for and methods of female genital skin reduction, improvement of skin tone and treatment of female urinary incontinence, as well as the treatment or improvement of other clinical conditions, including but not limited to those involving the female genitalia.
US08961576B2 Internal joint bracing system and suture anchoring assembly therefore
An internal bracing system is disclosed for stabilizing a joint such as the knee, shoulder, ankle or the like. The internal bracing system includes an extra-articular tension band mechanism and an anchor assembly therefore. The internal bracing system adds substantial control to unstable joints which is effective in limiting the pathological joint motions and internal slippage. The anchor anchoring assembly designed to affix a tethering device to various bony structures which form a joint, for the purpose of providing stability. The anchor assembly includes an anchor and a set screw. A double helix thread/chamber structure between the anchor and set screw securely holds the tether without binding.
US08961570B2 Spinal correction system and method
A fusionless correction system comprises a longitudinal element extending between a first end and second end. At least one fixation element is disposed with the longitudinal element and is configured for disposal in bone. A lock is disposed with the at least one fixation element and includes at least one bone penetrating projection. The lock is movable relative to the at least one fixation element between a first non-engaging configuration and a second engaging configuration such that the at least one bone penetrating projection extends beyond an outer surface of the at least one fixation element. Methods of use are disclosed.
US08961569B2 Locking pedicle screw devices, methods, and systems
An embodiment of the invention provides for a pedicle screw system including a bone anchor, linkage rod, tulip, set screw, and detent plate. When the set screw is fully tightened against the detent plate, pluralities of ridges on opposing faces of the detent plate and set screw cooperate by providing catches to prevent unwanted loosening of the set screw, which could lead to unwanted rod slippage and instability in the orthopedic fixation unit.
US08961567B2 Non-fusion scoliosis expandable spinal rod
A growing rod for mounting between attachment mechanisms that are secured to anatomical structures of a patient having scoliosis. The growing rod includes an outer housing and an inner housing disposed within the outer housing. The inner housing includes a magnet assembly including a magnet having a first pole and a second pole and a gear reduction mechanism coupled to the magnet. A first rod is secured to the inner housing and a second rod is secured to the outer housing. The gear reduction mechanism reduces an output rotation of the magnet to rotate a driver that operates to move the inner housing along a longitudinal axis with respect to the outer housing.
US08961561B2 Surgical system including suture anchor and insertion device and method for using
An improved suture anchor has one or more channels formed into the exterior surface of the anchor body. The channels may be used to inject a compound, such as filler material or an adhesive, into the implant site. Preferably, the channels connect to a retainer in the anchor body for a suture to pass through, preventing the suture from being compressed and allowing removal and adjustment of a suture retained by the anchor after the anchor is installed in a bone. The retainer is preferably a slot formed into the distal end of the anchor body. In a method of securing tissue to bone, an insertion tool is used to insert the suture into the anchor and install the anchor into an implant site in the bone. If the suture later fails, the channels may be used to fill the implant site with bone cement for redrilling. Preferably, the suture anchor is made of human cortical bone or a similarly bioabsorbable and osteoconductive material.
US08961560B2 Bidirectional self-retaining sutures with laser-marked and/or non-laser marked indicia and methods
A marked heterofunctional suture thread has two or more sections having different features. One or more sections of the suture thread are provided with laser-marked and non-laser marked indicia in order that they may be identified and differentiated from other sections. The suture thread may have retainers on the surface of one or more sections such that the suture thread can engage and retain tissue without knots. The markers may be used to indicate fixed features of a section of suture thread such as the presence and/orientation of retainers. In particular embodiments, laser-marked and non-laser marked indicia are used to identify the transition section of a bidirectional self-retaining suture.
US08961553B2 Material control device for inserting material into a targeted anatomical region
An extractable device is used to insert a flowable material into a vertebral body. The device comprises a filling member and a flowable material. The filling member is made of a flexible wall which includes a holding portion and an injection port via which the flowable material is injected into the holding portion after insertion into the vertebral body. The holding portion is provided with an opening which is releasably closed by a closure device so as to make the opening substantially resistant to the passage of material there through. Once the flowable material in the holding portion increases in viscosity, the closure device is released, thereby enabling the filling member to be extracted from the vertebral body so as to leave only the material in the vertebral body. The flowable material should be a material capable of setting to a hardened condition.
US08961549B2 Retrograde entry antegrade placement for femoral artery access
A Retrograde Entry Antegrade Placement (REAP) method and apparatus facilitate the antegrade (i.e., in the direction of blood flow) placement of endovascular devices for treatment of lower extremity arterial disease. Initially, a retrograde entry is made into the arterial system of a patient at an entry point with a curved needle, which then exits at an exit point proximal to the entry point, with a first wire then passed through the lumen of the curved needle. From the skin exit point, a Dual-Lumen Access Director (DAD) device is advanced in the antegrade direction down the first wire in a first lumen and enters the CFA 1 lumen. A second wire is passed down a second lumen in the DAD device and follows the SFA lumen in the antegrade direction. The DAD device is removed, and a standard dilator sheath is inserted over the second wire and the endovascular treatment begins.
US08961547B2 Ultrasonic surgical instruments with moving cutting implement
In various embodiments, a surgical instrument for operation in an aqueous environment is provided. In at least one embodiment, the surgical instrument may include a hollow sheath and a blade disposed at least partially within the sheath. Coupled to the blade may be at least one ultrasonic transducer, which, in turn, may be coupled to a drive system. The drive system may be configured to deliver gross axial motions to the blade such that the blade translates with respect to the hollow sheath when the drive system is activated. Accordingly, tissue may be cut by the blade with gross axial movement of the blade and/or ultrasonic vibrational motion provided by the ultrasonic transducer(s). In alternative embodiments, the blade may be rotated axially instead of translated with respect to the hollow sheath.
US08961545B2 Soft tissue anchoring methods and devices
Novel devices (120) and methods for soft tissue anchoring and securement are disclosed, such devices and methods offering the advantage of enabling secured tissue to withstand significant forces after such securement is complete. The novel tissue anchoring elements (28) include a force-distributing device that has a large surface area relative to conventional tissue securement devices such as sutures and staples. The force-distributing device (28) may be implanted to a controlled depth into the tissue mass by forming a pocket in a tissue mass and inserting the device, or by slowly driving the device into tissue means of an erosion mechanism such as local pressure necrosis (56). The erosion process may be driven by a force-producing element that may also include a tissue-grasping element (144).
US08961544B2 Dry composition wound dressings and adhesives comprising gelatin and transglutaminase in a cross-linked matrix
Patches comprising dry gelatin compositions.
US08961543B2 Tissue ligation devices and methods
Devices and methods for ligating structures where the loop of the ligation element can be temporarily pre-tightened without locking the loop. This pre-tightening without locking allows the loop of the ligation element to be loosened and repositioned, if necessary, before locking the loop around the anatomical structure.
US08961542B2 Articulating clip applier cartridge
An end effector is provided and includes a distal housing portion and a proximal housing portion interconnected to one another by a knuckle portion, wherein the knuckle portion permits rotation of the distal housing portion relative thereto and articulation of the distal housing portion relative to the proximal housing portion; a jaw assembly supported in the distal end of the distal housing portion, the jaw assembly including a first jaw and a second jaw movable between a spaced apart and an approximated position; and a plurality of fasteners loaded within the distal housing portion, each of the plurality of fasteners defining a fastener axis extending in a direction substantially parallel to a pair of legs thereof, each of the plurality of fasteners being arranged within the base portion such that the fastener axis is disposed at an angle with respect to a longitudinal axis of the distal housing portion.
US08961541B2 Vascular closure devices, systems, and methods of use
A tissue closure system can include a deployment instrument and a sealing element. The deployment instrument can be slidably mounted to and guided by a tubular medical device. The deployment instrument can be advanced over the tubular medical device to the desired location. The sealing element can then be advanced off of the end of the tool. The sealing element can include tissue engaging elements that are configured to automatically close upon deployment to bring together tissue. A slidably attached guided skin (or other tissue) cutter can also be used if desired to facilitate entry of the deployment instrument.
US08961539B2 Endoscopic implant system and method
A system, device, device and method for implanting a food restrictor in a patient's stomach, by coupling the restrictor to a plurality of tissue-plication anchors already placed in the stomach, are disclosed. The device includes an elongate shaft assembly for accessing the stomach transorally, and on which the restrictor can be carried, and a plurality of cable members mounted on the shaft assembly. The cable members are disposed on the shaft assembly along a distal section thereof, and releasably attached to the shaft assembly's distal end. After a cable member engages a tissue-plication anchor, retracting the cable is operable to first release the member from a holder at the distal end of the shaft assembly, then pull a portion of the anchor through an aperture in the restrictor. This process is repeated for each anchor in the stomach for attaching the restrictor to the stomach.