Document Document Title
US08928113B2 Layout scheme and method for forming device cells in semiconductor devices
A method and layout for forming word line decoder devices and other devices having word line decoder cells provides for forming metal interconnect layers using non-DPL photolithography operations and provides for stitching distally disposed transistors using a lower or intermediate metal layer or a subjacent conductive material. The transistors may be disposed in or adjacent longitudinally arranged word line decoder or other cells and the conductive coupling using the metal or conductive material lowers gate resistance between transistors and avoids RC signal delays.
US08928106B2 Electroconductive element, electroconductive element manufacturing method, wiring element, information input device, display device, and electronic apparatus
An electroconductive element includes a substrate having a first wavy surface and a second wavy surface, and an electroconductive layer formed on the first wavy surface, wherein the electroconductive layer forms an electroconductive pattern, and the first wavy surface and the second wavy surface satisfy the following relationship: 0≦(Am1/λm1)<(Am2/λm2)≦1.8. Am1 is a mean amplitude of vibrations of the first wavy surface, Am2 is a mean amplitude of vibrations of the second wavy surface, λm1 is a mean wavelength of the first wavy surface, and λm2 is a mean wavelength of the second wavy surface.
US08928105B2 Method and apparatus for thin film module with dotted interconnects and vias
A method to fabricate monolithically-integrated optoelectronic module apparatuses (100) comprising at least two series-interconnected optoelectronic components (104, 106, 108). The method includes deposition and scribing on an insulating substrate or superstate (110) of a 3-layer stack in order (a, b, c) or (c, b, a) comprising: (a) back-contact electrodes (122, 124, 126, 128), (b) semiconductive layer (130), and (c) front-contact components (152, 154, 156, 158). Via holes (153, 155, 157) are drilled so that heat of the drilling process causes a metallization at the surface of said via holes that renders conductive the semi-conductive layer's surface (132, 134, 136, 138) of said via holes, thereby establishing series-interconnecting electrical paths between optoelectronic components (104, 106, 108) by connecting first front-contact components (154, 156) to second back-contact electrodes (124, 126).
US08928104B2 Image sensor packaging structure with black encapsulant
An image sensor packaging structure with a low transmittance encapsulant is provided. The image sensor packaging structure includes a substrate, a chip, a transparent lid, and the low transmittance encapsulant. The chip is combined with the substrate. The transparent lid is adhered to the chip and cover above a sensitization area of the chip to form an air cavity. The low transmittance encapsulant is formed on the substrate and encapsulates the chip and the transparent lid so as to accomplish the package of the image sensor packaging structure. Due to the feature of prohibiting from light passing through the low transmittance encapsulant, the arrangement of the low transmittance encapsulant can avoid the light from outside interfere the image sensing effect of the image sensor. Therefore, the quality of the image sensing can be ensured.
US08928103B2 Solid-state imaging element, method of manufacturing the same, solid-state imaging apparatus, and imaging apparatus
A solid-state imaging element including a semiconductor substrate that has a light reception portion performing a photoelectric conversion of an incident light; an oxide layer that is formed on a surface of the semiconductor substrate; a light shielding layer that is formed on an upper layer further than the oxide layer via an adhesion layer; and an oxygen supply layer that is disposed between the oxide layer and the adhesion layer and is formed of a material which shows an oxidation enthalpy smaller than that of a material forming the oxide layer.
US08928100B2 Spin transfer torque cell for magnetic random access memory
Embodiments are directed to STT MRAM devices. One embodiment of an STT MRAM device includes a reference layer, a tunnel barrier layer, a free layer and one or more conductive vias. The reference layer is configured to have a fixed magnetic moment. In addition, the tunnel barrier layer is configured to enable electrons to tunnel between the reference layer and the free layer through the tunnel barrier layer. The free layer is disposed beneath the tunnel barrier layer and is configured to have an adaptable magnetic moment for the storage of data. The conductive via is disposed beneath the free layer and is connected to an electrode. Further, the conductive via has a width that is smaller than a width of the free layer such that a width of an active STT area for the storage of data in the free layer is defined by the width of the conductive via.
US08928099B2 Micromechanical component and method for the manufacture of same
A method for manufacturing a micromechanical component is described in which a trench etching process and a sacrificial layer etching process are carried out to form a mass situated movably on a substrate. The movable mass has electrically isolated and mechanically coupled subsections of a functional layer. A micromechanical component having a mass situated movably on a substrate is also described.
US08928098B2 Semiconductor package and fabrication method thereof
A semiconductor package includes: a chip having a first portion and a second portion disposed on the first portion, wherein the second portion has at least a through hole therein for exposing a portion of the first portion, and the first portion and/or the second portion has a MEMS; and an etch stop layer formed between the first portion and the second portion and partially exposed through the through hole of the second portion. The invention allows an electronic element to be received in the through hole so as for the semiconductor package to have integrated functions of the MEMS and the electronic element. Therefore, the need to dispose the electronic element on a circuit board as in the prior art can be eliminated, thereby saving space on the circuit board.
US08928097B2 Noise shielding techniques for ultra low current measurements in biochemical applications
A device having an integrated noise shield is disclosed. The device includes a plurality of vertical shielding structures substantially surrounding a semiconductor device. The device further includes an opening above the semiconductor device substantially filled with a conductive fluid, wherein the plurality of vertical shielding structures and the conductive fluid shield the semiconductor device from ambient radiation. In some embodiments, the device further includes a conductive bottom shield below the semiconductor device shielding the semiconductor device from ambient radiation. In some embodiments, the opening is configured to allow a biological sample to be introduced into the semiconductor device. In some embodiments, the vertical shielding structures comprise a plurality of vias, wherein each of the plurality of vias connects more than one conductive layers together. In some embodiments, the device comprises a nanopore device, and wherein the nanopore device comprises a single cell of a nanopore array.
US08928096B2 Buried-channel field-effect transistors
A buried-channel field-effect transistor includes a semiconductor layer formed on a substrate. The semiconductor layer includes doped source and drain regions and an undoped channel region. the transistor further includes a gate dielectric formed over the channel region and partially overlapping the source and drain regions; a gate formed over the gate dielectric; and a doped shielding layer between the gate dielectric and the semiconductor layer.
US08928092B2 Semiconductor devices and methods of fabricating the same
A semiconductor device includes a lower insulating pattern on a semiconductor substrate, a lower gate pattern on the lower insulating pattern and formed of a doped polysilicon layer, a residual insulating pattern with an opening exposing a portion of a top surface of the lower gate pattern, an upper gate pattern on the residual insulating pattern, the upper gate pattern filling the opening, and a diffusion barrier pattern in contact with the portion of the top surface of the lower gate pattern and extending between the residual insulating pattern and the upper gate pattern.
US08928090B2 Self-aligned contact structure for replacement metal gate
A metallic top surface of a replacement gate structure is oxidized to convert a top portion of the replacement gate structure into a dielectric oxide. After removal of a planarization dielectric layer, selective epitaxy is performed to form a raised source region and a raised drain region that extends higher than the topmost surface of the replacement gate structure. A gate level dielectric layer including a first dielectric material is deposited and subsequently planarized employing the raised source and drain regions as stopping structures. A contact level dielectric layer including a second dielectric material is formed over the gate level dielectric layer, and contact via holes are formed employing an etch chemistry that etches the second dielectric material selective to the first dielectric material. Raised source and drain regions are recessed. Self-aligned contact structures can be formed by filling the contact via holes with a conductive material.
US08928086B2 Strained finFET with an electrically isolated channel
A fin structure includes an optional doped well, a disposable single crystalline semiconductor material portion, and a top semiconductor portion formed on a substrate. A disposable gate structure straddling the fin structure is formed, and end portions of the fin structure are removed to form end cavities. Doped semiconductor material portions are formed on sides of a stack of the disposable single crystalline semiconductor material portion and a channel region including the top semiconductor portion. The disposable single crystalline semiconductor material portion may be replaced with a dielectric material portion after removal of the disposable gate structure or after formation of the stack. The gate cavity is filled with a gate dielectric and a gate electrode. The channel region is stressed by the doped semiconductor material portions, and is electrically isolated from the substrate by the dielectric material portion.
US08928085B2 Apparatus and method for electronic circuit protection
Apparatus and methods for electronic circuit protection are disclosed. In one embodiment, an apparatus comprises a well having an emitter and a collector region. The well has a doping of a first type, and the emitter and collector regions have a doping of a second type. The emitter region, well, and collector region are configured to operate as an emitter, base, and collector for a first transistor, respectively. The collector region is spaced away from the emitter region to define a spacing. A first spacer and a second spacer are positioned adjacent the well between the emitter and the collector. A conductive plate is positioned adjacent the well and between the first spacer and the second spacer, and a doping adjacent the first spacer, the second spacer, and the plate consists essentially of the first type.
US08928081B2 Semiconductor device having display device
A semiconductor integrated circuit having a high withstand voltage TFT and a TFT which is capable of operating at high speed in a circuit of thin film transistors (TFT) and methods for fabricating such circuit will be provided. A gate insulating film of the TFT required to operate at high speed (e.g., TFT used for a logic circuit) is relatively thinned less than a gate insulating film of the TFT which is required to have high withstand voltage (e.g., TFT used for switching high voltage signals).
US08928080B2 Field-effect transistor having back gate and method of fabricating the same
A back-bias region is disposed on a substrate. A buried insulating layer covers the substrate and the back-bias region. A body is formed on the buried insulating layer and partially overlaps the back-bias region. A drain is in contact with the body. A gate electrode covers top and lateral surfaces of the body.
US08928078B2 Double diffused metal oxide semiconductor device and manufacturing method thereof
The present invention discloses a double diffused metal oxide semiconductor (DMOS) device and a manufacturing method thereof. The DMOS device includes: a first conductive type substrate, a second conductive type high voltage well, a gate, a first conductive type body region, a second conductive type source, a second conductive type drain, a first conductive type body electrode, and a first conductive type floating region. The floating region is formed in the body region, which is electrically floating and is electrically isolated from the source and the gate, such that the electrostatic discharge (ESD) effect is mitigated.
US08928077B2 Superjunction structures for power devices
In one general aspect, a power device includes an active region having a plurality of pillars of a first conductivity type alternately arranged with a plurality of pillars of a second conductivity type where the plurality of pillars of the second conductivity type in the active region each have substantially the same width. The power device includes a termination region surrounding at least a portion of the active region and having a plurality of pillars of the first conductivity type alternately arranged with a plurality of pillars of the second conductivity type where the plurality of pillars of the second conductivity type in the active region each have substantially the same width and are smaller than each width of the pillars of the second conductivity type in the termination region. The power device includes a transition region disposed between the active region and the termination region.
US08928075B2 Power integrated circuit including series-connected source substrate and drain substrate power MOSFETs
A semiconductor device containing a high voltage MOS transistor with a drain drift region over a lower drain layer and channel regions laterally disposed at the top surface of the substrate. RESURF trenches cut through the drain drift region and body region parallel to channel current flow. The RESURF trenches have dielectric liners and electrically conductive RESURF elements on the liners. Source contact metal is disposed over the body region and source regions. A semiconductor device containing a high voltage MOS transistor with a drain drift region over a lower drain layer, and channel regions laterally disposed at the top surface of the substrate. RESURF trenches cut through the drain drift region and body region perpendicular to channel current flow. Source contact metal is disposed in a source contact trench and extended over the drain drift region to provide a field plate.
US08928066B2 Integrated circuit with power and sense transistors
An integrated circuit may include a semiconductor portion with a power transistor including first gate trenches that cross a first region and a sense transistor including second gate trenches that cross a second region. Each gate trench extends in a longitudinal direction and comprises a gate electrode and a field electrode. The first and second regions are arranged along the longitudinal direction. A first termination trench intersects at least the second gate trenches in a third region between the first and second regions. The first termination trench includes a first conductive structure that is electrically connected to the field electrodes in the second gate trenches. The characteristics of the sense transistor formed in the second region reliably and precisely replicate the characteristics of the power transistor.
US08928061B2 Three dimensional NAND device with silicide containing floating gates
A monolithic three dimensional NAND string includes a semiconductor channel located over a substrate, a plurality of control gates extending substantially parallel to the major surface of the substrate including a first control gate located in a first device level and a second control gate located in a second device level located over the substrate and below the first device level, a charge storage material including a silicide layer located in the first device level and in the second device level, a blocking dielectric located between the charge storage material and the plurality of control gates, and a tunnel dielectric located between the charge storage material and the semiconductor channel. The tunnel dielectric has a straight sidewall, portions of the blocking dielectric have a clam shape, and each of the plurality of control gates is located at least partially in an opening in the clam-shaped portion of the blocking dielectric.
US08928055B2 Magnetic memory element
According to one embodiment, a magnetic memory element includes a stacked body and a conductive shield. The stacked body includes first and second stacked units. The first stacked unit includes first and second ferromagnetic layers and a first nonmagnetic layer. The first ferromagnetic layer has a fixed magnetization in a first direction. A magnetization direction of the second ferromagnetic layer is variable in a second direction. The first nonmagnetic layer is provided between the first and second ferromagnetic layers. The second stacked unit includes a third ferromagnetic layer stacked with the first stacked unit in a stacking direction of the first stacked unit. A magnetization direction of the third ferromagnetic layer is variable in a third direction. The conductive shield is opposed to at least a part of a side surface of the second stacked unit. An electric potential of the conductive shield is controllable.
US08928052B2 Optoelectronic semiconductor chip and method for producing same
An optoelectronic semiconductor chip has a semiconductor layer sequence having an active layer that generates radiation between a layer of a first conductivity type and a layer of a second conductivity type. The layer of the first conductivity type is adjacent to a front side of the semiconductor layer sequence. The semiconductor layer sequence contains at least one cutout extending from a rear side, lying opposite the front side, of the semiconductor layer sequence through the active layer to the layer of the first conductivity type. The layer of the first conductivity type is electrically connected through the cutout by means of a first electrical connection layer which covers the rear side of the semiconductor layer sequence at least in places.
US08928050B2 Electronic device including a schottky contact
An electronic device can include a semiconductor layer having a primary surface, and a Schottky contact comprising a metal-containing member in contact with a horizontally-oriented lightly doped region within the semiconductor layer and lying adjacent to the primary surface. In an embodiment, the metal-containing member lies within a recess in the semiconductor layer and contacts the horizontally-oriented lightly doped region along a sidewall of the recess. In other embodiment, the Schottky contact may not be formed within a recess, and a doped region may be formed within the semiconductor layer under the horizontally-oriented lightly doped region and have a conductivity type opposite the horizontally-oriented lightly doped region. The Schottky contacts can be used in conjunction with power transistors in a switching circuit, such as a high-frequency voltage regulator.
US08928046B2 Transistor and method of fabricating the same
A transistor including a gate, an active stacked structure, a dielectric layer, a source and a drain. The gate is located over a first surface of the dielectric layer. The active stacked structure, including a first active layer and a second active layer, is located over a second surface of the dielectric layer. The source and the drain are located over the second surface of the dielectric layer and at two sides of the active stacked structure and extend between the first active layer and the second active layer of the active stacked structure.
US08928045B2 Semiconductor device
A channel region having a first conductivity type is disposed in a surface portion of a semiconductor substrate. A gate region having a second conductivity type is disposed in a surface portion of the channel region. A first semiconductor region having the second conductivity type is disposed under the channel region. Source/drain regions having the first conductivity type are disposed in parts of the surface portion of the channel region on both sides of the gate region in a channel length direction. Second semiconductor regions each having a high impurity concentration and the second conductivity type are disposed in parts of the semiconductor substrate on both sides of the channel region in a channel width direction.
US08928043B2 High voltage FET device with voltage sensing
A high voltage FET device provides drain voltage information with less overall silicon area consumption by forming a spiral resistance poly structure over a drift region of the high voltage FET device. The spiral resistance poly structure has an inner most end coupled to a drain region, and an outer most end coupled to a reference ground.
US08928040B2 Semiconductor device including line-type active region and method for manufacturing the same
A semiconductor device having a line-type active region and a method for manufacturing the same are disclosed. The semiconductor device includes an active region configured in a successive line type, at least one active gate having a first width and crossing the active region, and an isolation gate having a second width different from the first width and being formed between the active gates. The isolation gate's width and the active gate's width are different from each other to guarantee a large storage node contact region, resulting in increased device operation characteristics (write characteristics).
US08928039B2 Semiconductor device including heterojunction field effect transistor and Schottky barrier diode
According to one embodiment, a semiconductor device has a first nitride semiconductor layer, a second nitride semiconductor layer provided on the first nitride semiconductor layer and formed of a non-doped or n-type nitride semiconductor having a band gap wider than that of the first nitride semiconductor layer, a heterojunction field effect transistor having a source electrode, a drain electrode, and a gate electrode, a Schottky barrier diode having an anode electrode and a cathode electrode, and first and second element isolation insulating layers. The first element isolation insulating layer has a first end contacting with the drain electrode and the anode electrode, and a second end located in the first nitride semiconductor layer. The second element isolation insulating layer has a third end contacting with the cathode electrode, and a fourth end located in the first nitride semiconductor layer.
US08928035B2 Gallium nitride devices with gallium nitride alloy intermediate layer
The invention provides semiconductor materials including a gallium nitride material layer formed on a silicon substrate and methods to form the semiconductor materials. The semiconductor materials include a transition layer formed between the silicon substrate and the gallium nitride material layer. The transition layer is compositionally-graded to lower stresses in the gallium nitride material layer which can result from differences in thermal expansion rates between the gallium nitride material and the substrate. The lowering of stresses in the gallium nitride material layer reduces the tendency of cracks to form. Thus, the invention enables the production of semiconductor materials including gallium nitride material layers having few or no cracks. The semiconductor materials may be used in a number of microelectronic and optical applications.
US08928034B2 Gallium nitride devices with aluminum nitride alloy intermediate layer
The invention provides semiconductor materials including a gallium nitride material layer formed on a silicon substrate and methods to form the semiconductor materials. The semiconductor materials include a transition layer formed between the silicon substrate and the gallium nitride material layer. The transition layer is compositionally-graded to lower stresses in the gallium nitride material layer which can result from differences in thermal expansion rates between the gallium nitride material and the substrate. The lowering of stresses in the gallium nitride material layer reduces the tendency of cracks to form. Thus, the invention enables the production of semiconductor materials including gallium nitride material layers having few or no cracks. The semiconductor materials may be used in a number of microelectronic and optical applications.
US08928030B2 Semiconductor device, method for manufacturing the semiconductor device, and method for controlling the semiconductor device
An A-NPC circuit is configured so that the intermediate potential of two connected IGBTs is clamped by a bidirectional switch including two RB-IGBTs. Control is applied to the turn-on di/dt of the IGBTs during the reverse recovery of the RB-IGBTs. The carrier life time of an n− drift region in each RB-IGBT constituting the bidirectional switch is comparatively longer than that in a typical NPT structure device. A low life time region is also provided in the interface between the n− drift region and a p collector region, and extends between the n− drift region and the p collector region. Thus, it is possible to provide a low-loss semiconductor device, a method for manufacturing the semiconductor device and a method for controlling the semiconductor device, in which the reverse recovery loss is reduced while the reverse recovery current peak and the jump voltage peak during reverse recovery are suppressed.
US08928028B2 Organic electroluminescence element including metal doped molybdenum oxide layer and method for producing the same
It is an object of the present invention to provide an organic electroluminescence element which can be easily produced and has a good light-emitting property and a good lifetime property, and a method for producing the same.That is, the present invention provides the organic electroluminescence element comprising an anode, a light-emitting layer and a cathode, and further comprising a metal doped molybdenum oxide layer provided between the anode and the light-emitting layer; and the method for producing the organic electroluminescence element including a stacking step to obtain a metal doped molybdenum oxide layer by simultaneously depositing molybdenum oxide and a dopant metal on another layer which constitutes the element.
US08928023B1 Arrangement of solid state light sources and lamp using same
Arrangements of solid state light sources for color-mixing, and light sources including the same, are provided. A substrate has a plurality of different color LED chips coupled thereto. The emitted light is mixed to produce a white light output. The LED chips are arranged on the substrate in a manner that improves color-mixing, for example, by forming LED sets including one or more LED chips of different colors, by skewing the LED chips, and/or by forming a non-rectangular array or a circular array of LED sets and/or chips. The color-mixing LED arrangement may be used in a lamp or other light source together with collimating optics to collimate and further mix the color-mixed light output from the LED arrangement. The color-mixing LED arrangement may be provided as a single package with multiple LED chips or as multiple packages of one or more LED chips.
US08928009B2 Light emitting device, illuminating device, and display device
A light emitting device includes: one or plural light emitting elements having plural electrodes; a chip-like insulator surrounding the one or plural light emitting elements from a side surface side of the one or plural light emitting elements; and plural terminal electrodes electrically connected one-to-one with the plural electrodes, and having protrusions each protruding from a peripheral edge of the chip-like insulator.
US08928007B2 Electro-optical device, method for manufacturing electro-optical device, and electronic device
An electro-optical device includes: a pixel region that is formed on a substrate and in which a light emitting element that has a first electrode, a second electrode and a light emitting layer formed between the first electrode and the second electrode is arranged; a partition wall portion that is formed above the substrate and located on an outer side of the pixel region; a connecting line that is formed above the substrate and located on an outer side of the partition wall portion; and a connecting section that is formed above the substrate and electrically connects the second electrode to the connecting line, wherein the second electrode covers and extends over the pixel region and the partition wall portion and does not overlap the connecting line in a planar view.
US08928001B2 Group III nitride compound semiconductor light emitting element and method for producing the same
A group III nitride compound semiconductor light emitting device that inhibits occurrence of dislocation in a strain relaxation layer in forming a group III nitride compound semiconductor layer on a thin GaN substrate, and a method for producing the same are provided. A light emitting device 100 comprises a support substrate 10, a GaN substrate 20, an n-type contact layer 30, a strain relaxation layer 40 (n-type InGaN layer), a light emitting layer 50, a p-type clad layer 60, and a p-type contact layer 70. The GaN substrate 20 has a thickness in a range of from 10 nm to 10 μm. The strain relaxation layer 40 (n-type InGaN layer) has an In composition ratio X in a range of from larger than 0 to 3%.
US08928000B2 Nitride semiconductor wafer including different lattice constants
According to one embodiment, a nitride semiconductor wafer includes a silicon substrate, a lower strain relaxation layer provided on the silicon substrate, an intermediate layer provided on the lower strain relaxation layer, an upper strain relaxation layer provided on the intermediate layer, and a functional layer provided on the upper strain relaxation layer. The intermediate layer includes a first lower layer, a first doped layer provided on the first lower layer, and a first upper layer provided on the first doped layer. The first doped layer has a lattice constant larger than or equal to that of the first lower layer and contains an impurity of 1×1018 cm−3 or more and less than 1×1021 cm−3. The first upper layer has a lattice constant larger than or equal to that of the first doped layer and larger than that of the first lower layer.
US08927999B2 Edge termination by ion implantation in GaN
An edge terminated semiconductor device is described including a GaN substrate; a doped GaN epitaxial layer grown on the GaN substrate including an ion-implanted insulation region, wherein the ion-implanted region has a resistivity that is at least 90% of maximum resistivity and a conductive layer, such as a Schottky metal layer, disposed over the GaN epitaxial layer, wherein the conductive layer overlaps a portion of the ion-implanted region. A Schottky diode is prepared using the Schottky contact structure.
US08927995B2 Thin film transistor with anti-diffusion area that prevents metal atoms and/or ions from source/drain electrodes from shortening the channel length and display substrate having the thin film transistor
A thin film transistor includes a semiconductor pattern disposed on a substrate and a semiconductor pattern portion with a conductive or nonconductive characteristic, and a anti-diffusion portion on a side of the semiconductor pattern portion to prevent metal ions from being diffused along the semiconductor pattern portion. A first insulating layer covers the semiconductor pattern and has a first contact hole exposing a first region of the semiconductor pattern portion and a second contact hole exposing a second region of the semiconductor pattern portion. A gate electrode is disposed on the first insulating layer. A second insulating layer covers the gate electrode and has a third contact hole exposing the first region and a fourth contact hole exposing the second region. A source electrode is formed on the second insulating layer and connected to the first region, and a drain electrode is formed on the second insulating layer and connected to the second region.
US08927992B2 Display apparatus
A display apparatus includes a backlight module, a panel module, and a plurality of double-sided adhesive tapes. The backlight module includes a bezel. The frame has a supporting surface. The panel module includes a glass substrate and a plurality of chips. The glass substrate is disposed on the supporting surface. An edge of the glass substrate has a bonding region. The chips are disposed at the bonding region. The chips and the supporting surface are respectively located at two opposite sides of the glass substrate. The double-sided adhesive tapes are disposed between the supporting surface and the bonding region. Each of the double-sided adhesive tapes is located at a gap between two adjacent chips.
US08927989B2 Voltage contrast inspection of deep trench isolation
A method including forming a first test structure and a second test structure in electrical contact with an inner buried plate and an outer buried plate, respectively, where the first and second test structures each comprise a deep trench filled with a conductive material, and measuring the voltage of the inner buried plate and the outer buried plate immediately after the formation of a deep trench isolation structure, where the inner buried plate and the outer buried plate are positioned on opposite sides of the deep trench isolation structure.
US08927988B2 Self-sealed fluidic channels for a nanopore array
A method of forming a nanopore array includes patterning a front layer of a substrate to form front trenches, the substrate including a buried layer disposed between the front layer and a back layer; depositing a membrane layer over the patterned front layer and in the front trenches; patterning the back layer and the buried layer to form back trenches, the back trenches being aligned with the front trenches; forming a plurality of nanopores through the membrane layer; depositing a sacrificial material in the front trenches and the back trenches; depositing front and back insulating layers over the sacrificial material; and heating the sacrificial material to a decomposition temperature of the sacrificial material to remove the sacrificial material and form pairs of front and back channels, wherein the front channel of each channel pair is connected to the back channel of its respective channel pair by an individual nanopore.
US08927987B2 Semiconductor device including external connection pads and test pads
A semiconductor device according to one embodiment of this invention includes: a semiconductor chip; a plurality of external connection pads and a plurality of first test pads, both of which are formed in a central region of a top surface of the semiconductor chip; a plurality of external connection electrodes each formed on a corresponding one of the external connection pads, the external connection electrodes being for connecting the external connection pads and an outside of the semiconductor device.
US08927985B2 Semiconductor device
A semiconductor device includes first and second conductive layers over an insulating surface, a first insulating layer over the first and second conductive layers, first and second oxide semiconductor layers over the first insulating layer, third and fourth conductive layers over the first oxide semiconductor layer, a second insulating layer over the third and fourth conductive layers, and a fifth conductive layer over the second insulating layer. In the semiconductor device, the third conductive layer is electrically connected to the second conductive layer, the fifth conductive layer is electrically connected to the fourth conductive layer, the first oxide semiconductor layer has a region overlapping with the first conductive layer, the second oxide semiconductor layer has a region overlapping with the fifth conductive layer, and the second oxide semiconductor layer has a region intersecting with the second conductive layer.
US08927979B2 Light emitting device and method of manufacturing the same
A light emitting device having a structure in which oxygen and moisture are prevented from reaching light emitting elements, and a method of manufacturing the same, are provided. Further, the light emitting elements are sealed by using a small number of process steps, without enclosing a drying agent. The present invention has a top surface emission structure. A substrate on which the light emitting elements are formed is bonded to a transparent sealing substrate. The structure is one in which a transparent second sealing material covers the entire surface of a pixel region when bonding the two substrates, and a first sealing material (having a higher viscosity than the second sealing material), which contains a gap material (filler, fine particles, or the like) for protecting a gap between the two substrates, surrounds the pixel region. The two substrates are sealed by the first sealing material and the second sealing material. Further, reaction between electrodes of the light emitting elements (cathodes or anodes) and the sealing materials can be prevented by covering the electrodes with a transparent protective layer, for example, CaF2, MgF2, or BaF2.
US08927976B2 Organic EL element and production method for same
An organic EL element includes a hole injection layer yielding excellent hole conduction efficiency, and comprises: an anode; a cathode; a functional layer disposed between the anode and the cathode, and including a light-emitting layer containing organic material; the hole injection layer disposed between the anode and the functional layer; and a bank defining an area in which the light-emitting layer is to be formed, wherein the hole injection layer includes tungsten oxide, tungsten atoms constituting the tungsten oxide include both tungsten atoms with a valence of six and tungsten atoms with a valence less than six, the hole injection layer includes a crystal of the tungsten oxide, a particle diameter of the crystal being on an order of nanometers, an inner portion of the hole injection layer is depressed to define a recess, and an upper peripheral edge of the recess is covered with a part of the bank.
US08927974B2 Display apparatus and image pickup apparatus
A first light-emitting layer of a first organic electroluminescent element is disposed in common to a second organic electroluminescent element, a second light-emitting layer of the second organic electroluminescent element is disposed in contact with the first light-emitting layer and in the cathode side, and the first light-emitting layer is a light-emitting layer having an electron trapping property.
US08927967B2 Electrochemically-gated field-effect transistor, methods for its manufacture and use thereof
An electrochemically-gated field-effect transistor includes a source electrode, a drain electrode, a gate electrode, a transistor channel and an electrolyte. The transistor channel is located between the source electrode and the drain electrode. The electrolyte completely covers the transistor channel and has a one-dimensional nanostructure and a solid polymer-based electrolyte that is employed as the electrolyte.
US08927960B2 Gallium nitride based light emitting diode
A light emitting device including a substrate, a first conductive type semiconductor layer on the substrate, at least one InxGa1−xN layer (0
US08927954B2 Packaging device for the transport and/or storage of a radioactive medium
A packaging device for the transport and/or storage of a radioactive medium generating flammable gases and/or explosives via radiolysis, comprising a plurality of canisters intended to contain the radioactive medium, each canister defining an inner storage space accessible via an opening for filling the medium, on which plug-forming means are mounted. According to the invention, the device also comprises a structure forming a chamber, and means for placing in communication allowing a fluid communication to be set up between the inner storage space and the chamber.
US08927945B2 Drawing apparatus and method of manufacturing article by controlling drawing on shot region side of boundary of shot regions
A drawing apparatus performs drawing, with an array of charged particle beams, on shot regions arrayed on a substrate in a direction in parallel and with intervention of step movement of the substrate in the direction. The apparatus includes a driving device for relative movement between a stage and a charged-particle optical system in the direction. The optical system causes sub arrays (of charged particle beams), discretely arrayed in the direction, to be incident on the substrate, and includes deflectors configured to respectively deflect sub array sets each including at least one of the sub arrays. A controller controls the optical system and the driving device such that a region at one side of a boundary among the shot regions and a region at the other side are subjected to drawing not in parallel with a sub array existing over the boundary, but sequentially with intervention of the step movement.
US08927942B2 Ion source, nanofabrication apparatus comprising such source, and a method for emitting ions
A ion source comprises: a chamber, an injection to inject matter into the chamber, wherein said matter comprises at least a first species, a tip with an apex located in the chamber, wherein the apex has a surface made of a metallic second species, a generator to generate ions of said species, and a regulation system adapted to set operative conditions of the chamber to alternatively generate ions from the gaseous first species, and ions from the non-gaseous metallic second species.
US08927939B2 Radiation measurement apparatus and nuclear medicine diagnosis apparatus
The purpose of the present invention is to improve energy resolving power and prevent energy resolving power from deteriorating when a thick semiconductor detection element with a wide energy range is used, in a radiation measuring device using a semiconductor detector and a nuclear medicine diagnostic device. With the present invention, the purpose is achieved by pulsed wave value correction employing the difference of (Hs−Hf) between the pulsed wave height value Hs obtained from the slow speed shaping circuit, and the pulsed wave height value Hf obtained from the fast speed shaping circuit and normalized with respect to Hs. An even more desirable result may be obtained by employing either (Hs−Hf)/Hf or exp(k(Hs−Hf)/Hf), wherein k is a coefficient to be optimized, said optimization being dependent on the measurement assembly.
US08927937B2 Ionizing radiation detection
A detector array (110) includes a detector (112) configured to detect ionizing radiation and output a signal indicative of the detected radiation, wherein the detector at least includes a semiconductor element (118) and an illumination subsystem (120) configured to generate and transfer sub-band-gap illuminating radiation to selectively illuminate only a sub-portion of the semiconductor element in order to produce a spatially patterned illumination distribution inside the element.
US08927935B1 All electro optical based method for deconfliction of multiple, co-located directed energy, high energy laser platforms on multiple, near simultaneous threat targets in the same battle space
A general problem occurs when there are multiple High Energy Laser (HEL) systems designed to shoot down threat targets (e.g., rockets, artillery, and mortar (RAM), and unmanned aerial systems (UASs) and vehicles (UAVs)) in scenarios where there are multiple, simultaneous, impending threat targets. To achieve the highest target kill ratio or highest protection force efficiency, the HEL systems need to be independently allocated to unique threat targets at each specific time, such that the case where two or more HEL systems are shooting at the same target is avoided (referred to as “target deconfliction”). The present disclosure teaches an all electro optical (EO) solution that exploits the use and affects of the HELs focused on targets and, thus, eliminates the need for any battle management (BM) and command and control (C2) systems that are currently conventionally used for target deconfliction.
US08927934B2 Thermal infrared sensor and manufacturing method thereof
A thermal infrared sensor includes an infrared ray absorbing film that is thermally separated from a semiconductor substrate by a hollow part; and a temperature sensor configured to detect temperature changes of the infrared ray absorbing film. The infrared ray absorbing film includes an infrared ray antireflection structure configured with a sub wavelength structure, the infrared ray antireflection structure being provided on a surface of the infrared ray absorbing film facing the semiconductor substrate.
US08927933B1 Dual-band wide-angle absorber/thermal emitter
A dual-band wide-angle absorber/thermal emitter includes at least one primary layer having a permittivity described by the Drude-Lorentz model. At least one reflective secondary layer is associated with the primary layer.
US08927930B2 Charged particle device
A charged particle device includes a cylindrical column (102), a charged particle beam optical system disposed in the column; a sample stage (103) disposed on the column, and a support device (211, 212) supporting the column. The support device includes a simply supported structure that simply supports the column at a plurality of support points set along an axial line direction of the column. The support points for the column are disposed at positions corresponding to the positions of nodes of vibration of the column. In this way, the rigidity of the column can be increased without increasing the weight of the column itself, whereby vibrations acting on the column can be decreased.
US08927924B2 Optical leak detector for subsea equipment
A leak detector (190) includes a sensor head (260), a light source (200) optically coupled to the sensor head and operable to generate excitation light. A detector (205) is optically coupled to the sensor head and operable to detect fluorescence light. A signal processing unit (210) is coupled to the detector and operable to signal a leak condition responsive to an intensity of the fluorescence light exceeding a threshold. A fluid-tight enclosure (235) encloses at least the light source, the detector, and the signal processing unit.
US08927922B2 Fluid diagnostic devices and methods of using the same
A diagnostic apparatus includes a measurement head, a translating calibration element, and a calibration element actuator. The measurement head includes a diagnostic light source, a light sensor, and a measurement head body. The diagnostic light source operates at a diagnostic wavelength λD and the measurement head body supports the diagnostic light source and the light sensor in a spaced apart relationship across a target fluid passageway to define a diagnostic light path extending from the diagnostic light source to the light sensor. The translating calibration element is partially transparent to light at the diagnostic wavelength λD and the calibration element actuator is structurally configured to move the translating calibration element into and out of the target fluid passageway. A size and geometry of the translating calibration element is such that the translating calibration element occupies a substantial entirety of the diagnostic light path when moved into the target fluid passageway.
US08927920B2 Correcting gamma-ray energy spectra for pileup degradation
A method for correcting detected gamma ray spectra for the effects of energy analyzer pileup includes assigning detected gamma rays to channels in a multichannel analyzer (MCA). A pileup spectrum is estimated. The pileup spectrum is subtracted from the measured spectrum. The result thereof is compared to the preceding estimated pileup free spectrum and the estimating the pileup spectrum, subtracting the pileup spectrum and comparing is repeated until the difference between successive estimates of the pileup-free spectrum falls below a selected threshold.
US08927916B2 Focus assist system and method
Focus assist systems and methods for imaging devices are provided. The focus assist systems and methods display focus level data to a user. There are a variety of methods of displaying focus level data to a user, including, but not limited to, graphs, highlights, symbols, and varied levels of brightness or color.
US08927910B2 High power-density plane-surface heating element
An electrical heat production device comprising a thin resistive layer sandwiched between a pair of plates having high thermal and electrical conductivity, the stack of layers being insulated around the side surfaces. When a voltage potential is applied across the plates in the disclosed electrical heat production device, an electrical current flows across the resistive layer producing heat within the resistive layer that is conducted through the plates and across the outer surfaces of the plates. A guard heater can be positioned adjacent to one of the outer plate surfaces to bias the heat flow from the resistive layer toward the opposite outer plate surface, such that the apparatus can have a single planar heating surface.
US08927906B2 Heating device, coating/developing system, heating method, coating/developing method, and recording medium having program for executing heating method or coating/developing method
The disclosed heating device is to perform a heating process on an exposed substrate formed with a resist film before a developing process, the device including a heating part to perform a heating process on the exposed substrate, the heating part including a plurality of two-dimensionally arranged heating elements; a seating part provided at an upper side of the heating part, on which the substrate is disposed; and a control part to correct a setting temperature of the heating part based on temperature correction values, and to control the heating part based on the corrected setting temperature, during the heating process on one substrate by the heating part, wherein the temperature correction values being previously obtained from measured critical dimensions of the resist pattern in another substrate formed with the resist pattern through the heating process by the heating part and then the developing process.
US08927905B1 Auxiliary power unit for a vehicle
An auxiliary power unit has an auxiliary engine, an auxiliary compressor, and a generator, and includes fittings for integrating with a vehicle's heating and cooling systems. The fittings may include first and second heater fittings adapted to be operably integrated into the heating system of the vehicle for diverting flow of the radiator fluid to the auxiliary engine. The auxiliary power unit also includes an AC fitting adapted to be operably installed between the evaporator and the vehicle compressor for enabling flow of AC fluid from the evaporator to the auxiliary compressor, and an AC valve adapted to be operably installed between the vehicle compressor and the condenser for enabling flow of the AC fluid from either the vehicle compressor or the auxiliary compressor.
US08927902B2 Systems and methods for diagnosing secondary weld errors
A controller for a welding system adapted to determine a value of a weld secondary parameter across a weld secondary component based on a sensed parameter is provided. The controller may also be adapted to compare the determined value to a reference value range and to alert a user to a presence and location of a weld secondary error when the determined value is outside the referenced value range.
US08927893B2 Driver for switch in gas insulated switchgear and gas insulated switchgear having the same
A driver for a switch in a GIS (Gas Insulation Switchgear) includes a motor, a shaft connected with a moving contact of the switch, a gear connected with one terminal of the shaft and configured to transfer power of the motor to cause the shaft to reciprocate the moving contact through the shaft, a cam spline combined with the shaft and spaced apart from the gear, and a micro-switch connected with the cam spline and configured to control an operation of the motor.
US08927890B2 Capacitive keyswitch technologies
Described herein are techniques related to capacitance-based keyswitch technologies. According to one implementation, an apparatus includes a key with a floating electrode. The floating electrode pairs with a fixed electrode and a capacitance may be generated between them. The apparatus has a controller configured to measure the capacitance as the electrodes move relative to each other as the key is depressed and released. This Abstract is submitted with the understanding that it will not be used to interpret or limit the scope or meaning of the claims.
US08927887B2 Variable depth circuit interrupter assembly with interlock
An improved circuit interrupter assembly provides enablement of an interlock feature for a circuit interrupter situated within a cabinet having an external handle for switching the circuit interrupter between ON and OFF conditions when the cabinet door is closed. The improved circuit interrupter assembly includes a motion transfer apparatus that provides such enablement of the interlock feature for cabinets of any of a variety of depths. The motion transfer apparatus includes a Bowden cable that extends between a first retention assembly situated at the door of the cabinet and a second retention assembly situated at the interlock feature of the circuit interrupter. The Bowden cable has a biased drive cable that extends between a pair of elements and which thus transfers the motion of the cabinet door in its closed position to enable cooperation with the interlock.
US08927886B2 Load transfer switch for a tap changer
The present invention relates to a load transfer switch for a tap changer, comprising permanent main contacts that switch powerlessly for each phase. The general inventive concept lies in connecting the fixed permanent main contacts of side A or B of the load transfer switch by means of a movable rail-shaped permanent main contact that establishes an electrical connection to the corresponding permanent main contacts of the load line only in the end positions of the movable rail-shaped permanent main contact and in addition only provides for a single deflection for actuation, which connects in a purely compressive manner the plurality of contact fins of the corresponding fixed permanent main contact, which contact fins are connected in a resilient, articulated manner.
US08927885B2 Mechanical switch contact
The invention relates to a mechanical switch contact (10) for releasing, disconnecting, or switching over, in particular for an on-load tap changer of a step transformer, comprising at least two contact fingers or contact finger blocks (12, 14), which can each be pivoted between two end positions and which are connected to each other in an electrically conductive manner and which are each operatively connected to a rotatable switching shaft (18) by means of multi-arm joints (16), said switching shaft having all-around guide slots (24) for actuating the multi-arm joints (16) and for thereby deflecting the contact fingers or contact finger blocks (12, 14).
US08927884B2 Replaceable key module and keyboard with the same
A replaceable key module for a keyboard, comprising: a keycap holder, a springy member and a keycap. The keycap holder embraces an accommodation space, a first surface having an opening, and a second surface having a hole. The springy member is located on the second surface and within the accommodation space of the keycap holder. The keycap is movably connected to the springy member through the opening of the first surface of the keycap holder and capable of moving between a released position and a depressed position. The keycap is referred to as in a released position when not depressed and in a depressed position pushing the springy member to be deformed downwardly when depressed. By means of adjusting some factors such as hardness, length, material and pressing angle of the springy member, the user may obtain the key module with the specified pressure load as desired.
US08927883B2 Nursing platform with integrated weighing means
An infant-nursing platform includes a cushion adapted for supporting a baby while nursing. The cushion has a support surface. Weighing means are disposed within the cushion and operably coupled to the support surface to weigh the baby on the support surface of the cushion. A user interface device is operably coupled to the weighing means to obtain measurement information therefrom. The user interface device and produces an output in response to the measurement information obtained from the weighing means.
US08927878B2 Printed circuit board and electronic apparatus thereof
Embodiments of a printed circuit board (PCB) and an electronic apparatus are provided. The PCB includes a PCB substrate and a plurality of the pads. The PCB substrate is disposed with the plurality of the pads. The plurality of the pads include a first type of the pads and a second type of the pads. The first type of the pads adopts the solder mask defined structure, and the second type of the pads adopts the non-solder mask defined structure.
US08927877B2 Looped interconnect structure
Disclosed herein is a system and method for mounting packages by forming one or more wire loop interconnects, optionally, with a wirebonder, and mounting the interconnects to a mounting pad on a first substrate. A first and second stud ball may each have at least one flat surface be disposed on a single mounting pad, and a wire having a bend region and forming a loop may be disposed between the stud balls. The stud balls may be formed from a deformed mouthing node formed on a wire. The loop may be mounted on a mounting pad on a first substrate and a second substrate may be mounted on the loop via a conductive material such as solder.
US08927874B2 Flexible wiring substrate, method for assembling flexible wiring substrate, and method for manufacturing liquid jetting apparatus
A flexible wiring substrate includes: a flexible base material; a wire provided on the base material; and an inspection wire provided on the base material, having an inspection segment which breaks up under a condition that the inspection segment is folded with not less than a predetermined curvature and a non-inspection segment which does not break up under a condition that the non-inspection segment is folded with not less than the predetermined curvature.
US08927872B2 Thermal pad and method of forming the same
A thermal pad (602, 612, 622, 702, 712) formed on a Printed Circuit Board and a method (900) of formed the thermal pad (602, 612, 622, 702, 712) are provided. The thermal pad (602, 612, 622, 702, 712) comprises in its interior one or more coins (604, 614, 624, 704, 714) has a height equal to a thickness of the PCB, and is made of metal or alloy, inserted into a corresponding one of one or more plated cutouts straight through the PCB in the thermal pad, and bonded to side walls of the corresponding one of the one or more plated cutouts with a paste capable of resisting a temperature of 250° C. or above. The plurality of through via (606, 616, 626, 706, 716) are plated, and lugged with a solder mask. The thermal pad (602, 612, 622, 702, 712) has a flat top surface and a flat bottom surface, either of which is coplanar with a corresponding one of top and bottom surfaces of the PCB. A PCB having formed thereon the above thermal pad (602, 612, 622, 702, 712) is also provided.
US08927871B2 Connection terminal structure, interposer, and socket
A connection terminal structure includes a substrate having one surface and including a pad formed on the one surface, a bonding part constituted by a solder, and a connection terminal having first and second ends and including a fixing part formed on the first end and a connection part formed on the second end. The fixing part includes a first surface that is bonded to the pad by way of the bonding part. The connection terminal includes a pad facing surface that faces the pad and includes the first surface. The connection terminal includes at least one groove that is formed in the pad facing surface. The at least one groove extends from the first surface to the connection part. A portion of the solder that constitutes the bonding part fills in the at least one groove.
US08927858B2 Electric junction box
There is provided an electric junction box for ensuring a watertight performance even when a harness with various thickness is applied, including a box body, a tubular guide portion projecting from the box body and guiding a harness out of the box body, wherein the guide portion is provided with a plurality of wall portions, divided along the axial direction of the guide portion, and at least one of the wall portions is provided with a movable spurtle as a spurtle and a bending portion formed between the movable spurtle and the box body elastically deformable in the outside direction of the guide portion, and wherein the inner diameter of the guide portion in neutral state that the bending portion is not in elastic deformation is formed to fit the harness with a minimum outer diameter.
US08927857B2 Silicon: hydrogen photovoltaic devices, such as solar cells, having reduced light induced degradation and method of making such devices
A method of producing a photovoltaic device includes providing a stretchable substrate for the photovoltaic device; and stretching the substrate to produce a stretched substrate. The method further includes depositing a structure comprising hydrogenated amorphous silicon onto the stretched substrate; and subjecting the deposited hydrogenated amorphous silicon structure and the stretched substrate to a compressive force to form a compressively strained photovoltaic device.
US08927856B2 Optical device with anisotropic luminescent material
An optical device (1) is provided. The optical device comprising a switchable layer (2) at least one alignment layer (6) a light guiding system (5), whereas the switchable layer (2) comprises a luminescent material (3) for absorbing and emitting light, whereby the alignment of the luminescent material (3) is changeable and the light guiding system (5) guides the emitted light, whereby the switchable layer (2) is in contact with the at least one alignment layer (6) and the luminescent material (3) exhibits anisotropic properties, whereby the optical device (1) comprises a light energy-converting means (7), wherein the light guiding system (5) is in physical contact with the energy converting means (7).
US08927854B2 Solar cell and method for manufacturing the same
A solar cell includes a first conductivity type substrate; an emitter unit having a second conductivity type opposite to the first conductivity type, and forming a p-n junction with the substrate; an anti-reflective film positioned on the emitter unit; a plurality of first electrodes positioned on the anti-reflective film and connected with the emitter unit; and a second electrode connected with the substrate, wherein the emitter unit includes a first region and a second region that are positioned between an outermost first electrode among the plurality of first electrodes and the edge of the substrate, and a thickness of the first region gradually increases in going from the edge of the substrate to the outermost first electrode, and a thickness of the second region is uniform.
US08927849B2 Waste heat thermoelectric generator with auxiliary burner
A thermoelectric generator utilizing a number of thermoelectric modules to produce electric power from waste heat when waste heat is available and from an alternate heat source when waste heat is not available. In both cases hot gasses are directed along several separate paths so that all of the modules are provided with approximately equal hot side temperatures. In a preferred embodiment the engine exhaust exits into an octagonally-shaped plenum into eight separate heat exchangers. Eight modules are mounted in each of the heat exchangers for a total of 64 modules. Preferred embodiments of the present invention include an auxiliary combustion burner-blower unit producing a hot exhaust that exits into the plenum to provide electric power when the truck is not operating. Valve features are provided to control the temperature and exhaust flow rate through the generator.
US08927847B2 Glitch-free frequency modulation synthesis of sounds
A time-varying formant is generated at a formant frequency by generating first and second harmonic phase signals having first and second harmonic numbers, respectively, in relation to a modulation frequency. The first and second harmonic phase signals are generated in proportion to a master phase signal, which varies at the modulation frequency, modulo a factor corresponding to their harmonic numbers. First and second sound signals, based on the first and second harmonic phase signals, are frequency modulated to create an arbitrarily rich harmonic spectrum, depending on an FM index. The time-varying formant is generated by generating a time-varying combination of the first and second harmonic sound signals, weighting the first and second harmonic sound signals in accordance with their spectral proximities to the formant frequency. One or more of the harmonic numbers are updated when the time-varying formant frequency passes the frequency of either sound signal.
US08927846B2 System and method for analysis and creation of music
A method and system for analyzing patterns in the relationships of notes of an input piece of music. The method comprises generating a set of the most frequently occurring note pitches in ascending pitch order that matches an interval pattern, and detecting out-of-key pitches that lie outside of this interval pattern. One or more potential key sequence bifurcations are identified which represent a list of possible key sequences according to forwards and backwards analysis. By finding patterns of repetition in the chordal sequences that may be generated according to these key sequence bifurcations, a key sequence that allows the most frequently recurring chord sequences may be chosen. Chord sequences may be analyzed by using ghost chords, temporary harmonic structures that are created, updated and finalized over time according to a combination of essential and inessential note fragments. The method further comprises identifying non-harmony pitches according to the analyzed chord sequence.
US08927845B2 Electronic keyboard musical instrument
An electronic keyboard musical instrument, including: a housing having a lower casing having a bottom wall and an upper casing having a top wall, left and right walls being formed on at least one of the top wall and the bottom wall; a keyboard portion held by the housing; at least one speaker disposed at at least one end portion of the housing in its key arrangement direction, such that its sound emission surface faces rearward; a sound adjuster disposed in the housing so as to be located outward of the speaker in the left-right direction; and a plurality of protruding portions formed at the one end portion so as to protrude from the at least one of the top and bottom walls, wherein the sound adjuster is held by at least one of the protruding portions.
US08927843B2 Head fixing mechanism of drum
A head fixing mechanism includes a fixture fixed to a trunk portion and a coupling member which is threadably engaged with a fixture. The coupling member includes a main body which has a head portion that presses a head and a shaft portion that is threadably engaged with the fixture, and in which an axially extending insertion hole is formed, and an insertion member which is threadably engaged with the main body within the insertion hole. A bottom of the insertion hole is formed in the shaft portion, and in the shaft portion, a slit having a width smaller than the inside diameter of the insertion hole is formed, which divides the shaft portion in a circumferential direction. The insertion member is formed in a tapered shape, and the outside diameter of the leading end thereof is formed to be smaller than the width of the slit.
US08927840B2 Variable mechanical acoustic resonance component for musical instrument using defined resonance index
The present invention is a variable mechanical acoustic resonance component for a musical instrument and a method for producing a variable mechanical acoustic resonance component comprising of at least two segments, each segment having distinct resonance and tone properties dependant on the properties of the segment as specified in a resonance index.
US08927839B2 Stringed instrument hand rest
A hand rest for a guitar or other such stringed instrument configured to be positioned over strings of the stringed instrument such that a user of the stringed instrument may rest a hand on at least a portion of the hand rest while using the stringed instrument. Furthermore, the hand rest is configured to not interfere with a user striking one or more strings and the vibration of one or more strings.
US08927838B2 Universal musical string adjusting apparatus for use with a tuning device
There is provided a string adjusting apparatus configured to be used with a string tuning device and with a variety of tuning pegs associated with a variety of stringed musical instruments, the string adjusting apparatus comprising a plurality of peg connectors configured to be detachably coupled to the variety of tuning pegs, and a motor configured to be connected to the automatic tuning device and to be detachably coupled to the plurality of peg connectors. The apparatus further comprising a user interface and a processing unit for enabling a user to select a stringed musical instrument to tune among a displayed list of musical instruments and a processing unit connected to the user interface for receiving the user selection and for automatically determining, as a function thereof, an appropriate tuning frequency, an appropriate peg connector among the plurality of peg connectors and an appropriate torque to be applied by the motor.
US08927832B1 Maize inbred PH1W2K
A novel maize variety designated PH1W2K and seed, plants and plant parts thereof. Methods for producing a maize plant that comprise crossing maize variety PH1W2K with another maize plant. Methods for producing a maize plant containing in its genetic material one or more traits introgressed into PH1W2K through backcross conversion and/or transformation, and to the maize seed, plant and plant part produced thereby. Hybrid maize seed, plant or plant part produced by crossing the variety PH1W2K or a locus conversion of PH1W2K with another maize variety.
US08927825B1 Maize hybrid X13C790
A novel maize variety designated X13C790 and seed, plants and plant parts thereof, produced by crossing Pioneer Hi-Bred International, Inc. proprietary inbred maize varieties. Methods for producing a maize plant that comprises crossing hybrid maize variety X13C790 with another maize plant. Methods for producing a maize plant containing in its genetic material one or more traits introgressed into X13C790 through backcross conversion and/or transformation, and to the maize seed, plant and plant part produced thereby. This invention relates to the maize variety X13C790, the seed, the plant produced from the seed, and variants, mutants, and minor modifications of maize variety X13C790. This invention further relates to methods for producing maize varieties derived from maize variety X13C790.
US08927824B2 Hybrid tomato ‘ESAS’
A new and distinct variety of paste-type hybrid tomato plant is described that is derived in part from an Amish tomato, and in part from a Big Bertha Pepper. This hybrid tomato has 2-4 lobes similar to a pepper, a hardy skin, and remains on the vine when ripe until frost. When picked ripe, this tomato lasts longer without rotting than normal tomatoes. Some of these tomatoes have been eaten after 3 months from picking. The fruit usually shrinks inside itself after some time from picking.
US08927821B2 Soybean cultivar WN1013087
The present invention is in the field of soybean variety WN1013087 breeding and development. The present invention particularly relates to the soybean variety WN1013087 and its progeny, and methods of making WN1013087.
US08927814B1 Soybean variety XBP52005
A novel soybean variety, designated XBP52005 is provided. Also provided are the seeds of soybean variety XBP52005, cells from soybean variety XBP52005, plants of soybean XBP52005, and plant parts of soybean variety XBP52005. Methods provided include producing a soybean plant by crossing soybean variety XBP52005 with another soybean plant, methods for introgressing a transgenic trait, a mutant trait, and/or a native trait into soybean variety XBP52005, methods for producing other soybean varieties or plant parts derived from soybean variety XBP52005, and methods of characterizing soybean variety XBP52005. Soybean seed, cells, plants, germplasm, breeding lines, varieties, and plant parts produced by these methods and/or derived from soybean variety XBP52005 are further provided.
US08927813B2 Soybean variety A1036054
The invention relates to the soybean variety designated A1036054. Provided by the invention are the seeds, plants and derivatives of the soybean variety A1036054. Also provided by the invention are tissue cultures of the soybean variety A1036054 and the plants regenerated therefrom. Still further provided by the invention are methods for producing soybean plants by crossing the soybean variety A1036054 with itself or another soybean variety and plants produced by such methods.
US08927812B2 Methods for increasing the resistance of plants to fungi by silencing the fungal SMT1-gene
The present invention relates to methods for generating or increasing resistance to at least one fungi, in particular soy bean rust, in a plant or a part of a plant by the expression of RNA which is at least partial complementary and/or identical to the STM1-gene, wherein the RNA is capable to provide ds-RNA and/or siRNA and/or miRNA. Moreover, the invention relates to respective plants, parts thereof and vector constructs capable to provide such RNA and the use of such vector constructs to provide fungal resistant plants.
US08927811B2 Plants with enhanced size and growth rate
Polynucleotides and polypeptides incorporated into expression vectors have been introduced into plants and were ectopically expressed. The polypeptides of the invention regulate transcription in these plants and have been shown to confer at least one regulatory activity that results in increased size, biomass, growth rate, and/or yield as compared to a control plan.
US08927808B2 Potyvirus resistance in potato
The present invention is drawn to novel genes from wild plants, such as wild potato and pepper plants, that confer potyvirus resistance to plants, such as in transformed cultivated plants. Also encompassed are cultivated plants transformed with the novel gene, food products made from the transformed cultivated plants, and methods for making such plants and food products.
US08927799B2 Propane dehydrogenation process utilizing fluidized catalyst system
A process for the production of propylene from a propane rich hydrocarbon source is presented. The process converts a propane rich stream and uses less equipment and energy for the separation and production of propylene. The process uses a non-noble metal catalyst and utilizes a continuous reactor-regeneration system to keep the process on line for longer periods between maintenance.
US08927796B2 Base oil upgrading by co-feeding a ketone or beta-keto-ester feedstock
This invention discloses a process for making high viscosity index lubricating base oils having a viscosity index of at least 110 by co-feeding a ketone or a beta-keto-ester feedstock with a lubricant oil feedstock directly to a hydrocracking unit to produce a hydrocracked stream. Then at least a portion of the hydrocracked stream is treated under hydroisomerization conditions to produce a high viscosity index lubricating base oil. The process may involve bypassing a hydrotreating or hydrofinishing step, which may result in improved efficiency and economics in producing high viscosity index lubricating base oils.
US08927794B2 Process for regenerating a coked catalytic cracking catalyst
A process for regenerating a coked catalytic cracking catalyst which the carbon-containing deposits on the catalyst contains at least 1 wt % bio-carbon, based on the total weight of carbon present in the carbon-containing deposits is provided. Such coked catalytic cracking catalyst is contacted with an oxygen containing gas at a temperature of equal to or more than 550° C. in a regenerator to produce a regenerated catalytic cracking catalyst, heat and carbon dioxide.
US08927792B2 Process for the production of chlorinated and/or fluorinated propenes
Processes for the production of chlorinated and/or fluonnated propenes provide good product yield with advantageous impurity profiles in the crude product. Advantageously, the processes may be conducted at lower temperatures than 600° C., or less than 500° C., so that energy savings are provided, and/or at higher pressures so that high throughputs may also be realized. The use of catalysts or initiators may provide additional enhancements to conversion rates and selectivity, as may adjustments to the molar ratio of the reactants.
US08927791B2 Method for producing tetrafluoropropenes
The current invention relates to a process for making a tetrafluoropropene using a tetrafluorochloropropane and/or a pentafluoropropane as starting or intermediate reagents. More specifically, though not exclusively, the present invention relates to a novel method for preparing a tetrafluoropropene by dehydrohalogenating a starting or intermediate tetrafluorochloropropane and/or pentafluoropropane material in the presence of a caustic solution at a temperature range greater than 40° C. and less than or equal to 80° C.
US08927790B2 Multiple vapor feeds for hydrogenation process to produce alcohol
The present invention relates to processes for the recovery of ethanol from a crude ethanol product obtained from the hydrogenation of acetic acid. The crude ethanol product is separated in a column to produce a distillate stream comprising ethyl acetate, ethanol and acetaldehyde and a residue stream comprising ethanol, acetic acid and water. The ethanol product is recovered from the residue stream. A liquid recycle stream is sent to a second vaporizer to form a second vapor feed stream that is fed to the hydrogenation reactor.
US08927789B1 Synthesis of high caloric fuels and chemicals
In one embodiment, the present application discloses methods to selectively synthesize higher alcohols and hydrocarbons useful as fuels and industrial chemicals from syngas and biomass. Ketene and ketonization chemistry along with hydrogenation reactions are used to synthesize fuels and chemicals. In another embodiment, ketene used to form fuels and chemicals may be manufactured from acetic acid which in turn can be synthesized from synthesis gas which is produced from coal, biomass, natural gas, etc.
US08927788B2 Process to recover alcohol with reduced water from overhead of acid column
A process for recovering ethanol obtained from the hydrogenation of acetic acid. The crude ethanol product is separated in a column to produce a distillate stream comprising acetaldehyde and ethyl acetate and a residue stream comprising ethanol, acetic acid, ethyl acetate and water. The ethanol product is recovered from the residue stream.
US08927787B2 Process for controlling a reboiler during alcohol recovery and reduced ester formation
The present invention is related to processes for the separation of ethanol from a crude ethanol product obtained from the hydrogenation of acetic acid. The crude ethanol product is separated in one or more columns. A reboiler is used following one or more of the columns for reducing ester formation.
US08927786B2 Ethanol manufacturing process over catalyst having improved radial crush strength
Acetic acid is hydrogenation in the presence of a catalyst comprising one or more active metals on a silica support, wherein the catalyst has a radial crush strength of at least 4 N/mm. The one or more active metals may include cobalt, copper, gold, iron, nickel, palladium, platinum, iridium, osmium, rhenium, rhodium, ruthenium, tin, zinc, lanthanum, cerium, manganese, chromium, vanadium, molybdenum and mixtures thereof. Radial crush strength may be improved by steam treating the catalyst support prior to the loading of the one or more active metals.
US08927782B2 Vapor separation in alcohol production
Two or more vapor-liquid separators are used in a process for removing at least one non-condensable gas from a crude alcohol mixture prepared by hydrogenating alkanoic acid and/or esters thereof. The vapor-liquid separators may comprise flashers or knock-out pots and are suitable for removing non-condensable gas, including those gases that are dissolved in the liquid. The multiple vapor-liquid separators may be in series prior to any separation of organic components. In addition, there may be a vapor-liquid separator before and after a distillation column for treating the feed to the column.
US08927780B2 Process for removing aldehydes from ethanol reaction mixture
A process for purifying an ethanol stream that comprises byproduct, such as aldehyde, acetals, and/or esters, but withdrawing a sidestream comprising ethanol from a distillation column. The sidestream may have a reduced concentration of aldehyde that reduces the formation of acetals in subsequent purification of the ethanol stream.
US08927772B2 Tertiary amine preparation process
The present invention relates to a process for producing a tertiary amine, including the following steps (1) and (2):Step (1); introducing an alcohol having 1 to 36 carbon atoms and a raw amine represented by the following general formula (I) into a first reaction vessel to react with each other in the presence of a catalyst and hydrogen, and then continuing the reaction while discharging water produced in the reaction and a hydrogen-containing gas out of a reaction system in the first reaction vessel: R1R2NH  (I) wherein R1 and R2 are each independently a hydrogen atom or a hydrocarbon group having 1 to 36 carbon atoms; and Step (2): introducing the hydrogen-containing gas discharged from the first reaction vessel into a second reaction vessel to reduce an amount of carbon monoxide contained in the hydrogen-containing gas, and then introducing a part or whole of the hydrogen-containing gas into the first reaction vessel.
US08927771B2 Pharmaceutically acceptable cocrystals of N-[2-(7-methoxyl-1-naphtyl)ethyl]acetamide and methods of their preparation
The present invention relates to novel solid forms of agomelatine (I), specifically novel phaamaceutically acceptable cocrystals thereof, as well as to methods of preparing them. Three pharmaceutically acceptable cocrystals of (I) that have physico-chemical properties acceptable for pharmaceutical development were obtained.
US08927766B2 Hydrocarboxylation of methylene dipropionate in the presence of a propionic acid and a homogeneous catalyst
Disclosed is a process for the production and purification of glycolic acid or glycolic acid derivatives by the carbonylation of methylene dipropionate in the presence of a homogeneous acid catalyst and propionic acid. This invention discloses hydrocarboxylations and corresponding homogeneous acid catalyst and glycolic acid separations. The homogeneous acid catalyst is readily separated from the hydrocarboxylation reaction effluent and recycled and the propionic acid is readily removed from the glycolic acid and the propionic acid is recycled.
US08927764B2 Process for producing terephthalic acid
Methods of producing terephthalic acid are described. The methods involve using a substantially pure 4-CBA stream. The substantially pure 4-CBA stream, a solvent comprising an ionic liquid and optionally a carboxylic acid, a bromine source, a catalyst, and an oxidizing agent are contacted to produce a product comprising terephthalic acid.
US08927762B2 Production of oxygenated compounds from carbon monoxide and dimethyl carbonate
A method of producing at least one oxygenated compound, such as methyl acetate, dimethyl ether, and formaldehyde, by reacting dimethyl carbonate and carbon monoxide in the presence of a faujasite zeolite, zeolite Beta, Linde Type L (LTL) zeolite, or MCM-41 zeolite.
US08927761B2 Form of hexyl-5-aminolevulinate hydrochloride and methods of using the same
This invention relates to a novel crystalline polymorph of hexyl-5-aminolevulinate hydrochloride, referred to hereinafter as Form C, which is useful as precursor of a photo sensitizer in the photodynamic diagnosis and treatment of metabolically active cells related to diseases such as cancer of the uterus, cervix, vagina, rectum, colon, lower gastrointestinal tract; infection associated with cancer caused by human papilloma virus; non-cancerous lower gastrointestinal tract a human; inflammatory bowel disease; ulcerative colitis; Crohn's disease; inflammatory bowel syndrome; dysplasia of the female reproductive system; anus; penis; rosacea; and acne and which is suitable for use as the active ingredient of a commercial pharmaceutical product. The invention relates further to methods of preparing Form C and using it in the described pharmaceutical compositions.
US08927760B2 Colchicine derivatives or pharmaceutically acceptable salts thereof, method for preparing said derivatives, and pharmaceutical composition comprising said derivatives
The present invention relates to colchicine derivatives expressed in chemical formula 1, or to pharmaceutically acceptable salts thereof, to a method for preparing said derivatives, and to a pharmaceutical composition comprising said derivatives. The colchicine derivatives according to the present invention exhibit superior immunomodulatory effects as compared with conventional immunomodulators or colchicines, and therefore can be valuably used as an immunomodulator for modulating an acute or chronic immune response in organ transplantation.
US08927756B2 Method for producing carbamate compound, carbamate compound, and method for producing isocyanate compound using same
The present invention relates to a method of producing a carbamate compound, comprising reacting a fluorine-containing carbonic diester compound represented by formula (1) and a non-aromatic diamine compound represented by formula (2) without using a catalyst, to thereby produce a carbamate compound represented by formula (3), and a method of producing an isocyanate compound represented by formula (20) from the carbamate compound without using a catalyst, wherein R represents a fluorine-containing monovalent aliphatic hydrocarbon group, and A represents a divalent aliphatic hydrocarbon group, a divalent alicyclic hydrocarbon group or a divalent aromatic-aliphatic hydrocarbon group.
US08927755B2 I- and II-type crystals of L-alpha-glyceryl phosphoryl choline, and method for preparing same
The present invention relates to I- and II-type crystals of L-α-glyceryl phosphoryl choline, and to a method for preparing same. More particularly, the present invention relates to noble I- and II-type anhydride crystals of L-α-glyceryl phosphoryl choline, which have a higher purity than conventional liquid L-α-glyceryl phosphoryl choline, and one advantage of which is that formulations and dosages of pharmaceuticals are easily modified, and another advantage of which is that the hygroscopicity of the crystals are much lower than that of conventional polymorphic crystals, providing excellent stability during storage. The present invention also relates to a method for preparing the I- and II-type crystals of L-α-glyceryl phosphoryl choline.
US08927753B2 Method for preparing di-organo-dialkoxysilanes
The present invention relates to a method for preparing di-organo-dialkoxysilanes, in particular di-organo-dialkoxysilanes wherein one or both of the organic substituents are bulky. The method comprises reacting a tetraalkoxysilane compound with a first Grignard reagent to form a mono-organo-tri-alkoxysilane compound, which is then reacted with a chlorinating agent to form a chlorinated mono-organo-di-alkoxysilane which is then reacted with a second Grignard reagent to form the di-organo-di-alkoxysilane compound.
US08927748B2 Alkyl-substituted allyl carbonyl metal complexes and use thereof for preparing dielectric thin films
Organometallic complexes and use thereof in thin film deposition, such as CVD and ALD are provided herein. The organometallic complexes are (alkyl-substituted η3-allyl)(carbonyl)metal complexes.
US08927742B2 Process for preparing Nebivolol
The present invention relates to a process for preparing Nebivolol and, more particularly, to an improved method of debenzylation of a compound of formula (II) useful for preparing nebivolol endowed with high purity.
US08927740B2 Asymmetric reduction process
The present invention relates to a stereoselective reduction procedure to obtain, by means of catalytic asymmetric hydrogenation by hydrogen transfer, a compound of formula (I) in which X is S or SO2 and R4 is hydrogen or an SO2NH2 group, from the corresponding ketone precursor, said compound of formula (I) being useful as an intermediate in the preparation of dorzolamide or of the hydrochloride salt thereof.
US08927739B2 Processes for the preparation of 5-azaspiro[2.4]heptane-6-carboxylic acid and its derivatives
The present invention relates generally to an improved process for the preparation of 5-azaspiro[2.4]heptane-6-carboxylic acid and its derivatives which are useful intermediates in the synthesis of biologically active molecules, especially in the synthesis of hepatits C virus NS5A inhibitors. In particular, the present invention relates to processes and intermediates for the preparation of compounds of formulae (Ia), (Ib) and (Ic):
US08927732B2 Biotin stannane for HPLC-free radioiodination
The present teachings provide methods that enable the preparation and purification of radioiodinated vectors without the need for HPLC purification, as well as novel precursors which include biotin-like substituents useful in such methods.
US08927729B2 Pesticidal compositions
Pesticidal compositions and their uses are disclosed.
US08927728B2 Dipeptide acetylene conjugates and a method for photocleavage of double strand DNA by dipeptide acetylene conjugates
Photoreactive DNA cleaving conjugate compounds are provided comprising a DNA cleaving moiety which comprises an aryl alkyne group and a polyfunctional pH-regulated DNA-binding moiety which comprises at least one or two amino groups.
US08927727B2 Thiol detection
Embodiments of compounds for selectively detecting a thiol are disclosed. In some embodiments, the compounds are bridged viologens, and the compounds are capable of reacting with homocysteine and/or glutathione in a buffered solution to produce a change in the solution's absorbance spectrum and/or emission spectrum. Also disclosed are embodiments of methods and kits for detecting homocysteine and/or glutathione with the disclosed bridged viologens.
US08927725B2 Thio compounds
A compound, or a pharmaceutically acceptable salt or ester thereof, having a structure of: wherein A, B and D are each oxygen or sulfur, provided that least one of A, B and D is sulfur; and R1-R8 are each independently hydrogen, hydroxyl, acyl, substituted acyl, acyloxy, substituted acyloxy, alkyl, substituted alkyl, alkenyl, substituted alkenyl, alkynyl, substituted alkynyl, alkoxy, substituted alkoxy, aryl, substituted aryl, amino, substituted amino, halogen, heterocycloalkyl, substituted heterocycloalkyl, heteroaryl, substituted heteroaryl, or a thio-containing group.
US08927722B2 Processes and intermediates for preparing a macrocyclic protease inhibitor of HCV
The present invention relates to the cinchonidine salt useful in the preparation of intermediates for preparing a macrocyclic HCV inhibitor, as well as processes involving this salt.
US08927714B2 Process for preparing dihydridodicyanoborate salts
The invention relates to a process for the preparation of alkali-metal salts with dihydridodicyanoborate anions by reaction of alkali-metal tetrahydridoborates or trihydridocyanoborates with trialkylsilyl cyanide and further reaction thereof in metathesis reactions.
US08927712B2 Process for the preparation of a mono-N-alkylpiperazine
Process for the preparation of a mono-N-alkylpiperazine of the formula I in which R1 is C1- to C5-alkyl or 2-(2-hydroxyethoxy)ethyl, by reacting diethanolamine (DEOA) of the formula II with a primary amine of the formula H2N—R1 (III) in the presence of hydrogen and a catalyst molding, where the reaction is carried out in the liquid phase at an absolute pressure in the range from 150 to 250 bar and the amination is carried out by means of a catalyst molding, the precursor of which can be prepared according to a process in which (i) an oxidic material comprising copper oxide, aluminum oxide and lanthanum oxide is provided, (ii) pulverulent metallic copper and/or copper flakes and optionally graphite is added to the oxidic material, (iii) the mixture resulting from step ii is shaped to give a molding, where the oxidic material is obtainable by simultaneous or successive precipitation of the component copper oxide, of the component aluminum oxide and of the component lanthanum oxide and subsequent drying and calcination and, after the shaping according to step iii, the catalyst molding is calcined again.
US08927707B2 Purification method of aztreonam
It discloses a process for refining Aztreonam, comprising the steps of 1) treating Aztreonam material with an alkali metal alkoxylate or an alkali earth metal alkoxylate under heating in the presence of a suitable solvent or a mixture of solvents, followed by adjusting the pH value with a suitable acid and cooling down to precipitate Aztreonam, which provides a primary purified Aztreonam; 2) adsorbing Aztreonam with strongly basic ion exchange resin, followed by eluting the resin and collecting the eluate, to provide a secondary purified Aztreonam after concentration under reduced pressure; 3) adjusting the pH value with a suitable acid to allow crystallization, followed by centrifuging and washing the resultant crystals, to provide a tertiary purified Aztreonam after drying. The refined Aztreonam product has a purity of no less than 99.2%, mostly no less than 99.5%, with little residue on ignition and significantly low content of heavy metals.
US08927706B2 Based-assisted formation of tin-sucrose adducts
A method of forming a sucrose-6-ester includes in sequence the steps of: a) contacting sucrose with a organotin-based acylation promoter in a solvent in the presence of a base selected from amines and basic alkali metal salts; b) removing water to form a tin-sucrose adduct; and c) contacting the tin-sucrose adduct with an acylating agent to form the sucrose-6-ester. The sucrose-6-ester may then be converted to sucralose.
US08927705B2 Single stranded extended dicer substrate agents and methods for the specific inhibition of gene expression
The invention provides compositions and methods for reducing expression of a target gene in a cell, involving contacting a cell with an isolated double stranded nucleic acid (dsNA) in an amount effective to reduce expression of a target gene in a cell. The dsNAs of the invention possess a single stranded extension (in most embodiments, the single stranded extension comprises at least one modified nucleotide and/or phosphate back bone modification). Such single stranded extended Dicer-substrate siRNAs (DsiRNAs) were demonstrated to be effective RNA inhibitory agents compared to corresponding double stranded DsiRNAs.
US08927704B2 Sense oligonucleotide capable of controlling the expression of iNOS and composition comprising the same
The invention relates to sense oligonucleotide having a sequence complementary to a single-stranded RNA (antisense transcript) having a sequence complementary to mRNA of iNOS gene in order to control expression of iNOS (inducible nitric oxide synthase). The sense oligonucleotide of the present invention can control expression of iNOS and is useful for biological defense and treatment and prevention of diseases related to excessive production of NO, such as cancerogenesis, inflammatory disease, endotoxin shock by bacterial infection and the like.
US08927701B2 HPIV-2 variants and their medical applications
A variant phylogenetic group of HPIV-2, more particularly a novel variant phylogenetic sub-group of HPIV-2, and a means for diagnosing HPIV-2 which take into account this novel group and this novel sub-group.
US08927700B2 Catalytic domains from lysyl oxidase and LOXL2
Disclosed herein are amino acid sequences, and encoding nucleotide sequences, of isolated catalytic domains of the LOX and LOXL2 proteins from human and mouse. Methods for the preparation and use of these isolated catalytic domains are also provided.
US08927699B2 Methods for obtaining thermostable enzymes, DNA polymerase I variants from Thermus aquaticus having new catalytic activities, methods for obtaining the same, and applications to the same
A thermostable mutant DNA polymerase; a method for obtaining the thernmostable mutant DNA polymerase by identifying a thermostable mutant polypeptide exhibiting enzymatic activity, wherein the thermostable mutant polypeptide is a variant of DNA polymerase I obtained from Thermus aquaticus; a polynucleotide, an expression vector, and a host cell encoding the thermostable mutant DNA polymerase; and a method of performing a reverse transcription polymerase chain reaction (RT-PCR) utilizing the thermostable mutant DNA polymerase, as well as a kit for facilitating the same.
US08927697B2 PD-1 specific antibodies and uses thereof
One aspect of the present disclosure provides antibodies that can act as agonists of PD-1, thereby modulating immune responses regulated by PD-1. Another aspect of the disclosure provides compositions comprising PD-1 specific antibodies and their use in methods of down regulating the immune response. These methods can be practiced on any subject, including humans or animals. Anti-PD-1 antibodies disclosed herein may be used, in another aspect of the invention, to detect PD-1 or its fragments in a biological sample. The amount of PD-1 detected may be correlated with the expression level of PD-1, and associated with the activation status of immune cells (e.g., activated T cells, B cells, and/or monocytes) in the subject.
US08927691B2 Transducible polypeptides for modifying metabolism
Methods and compositions for modifying the metabolism of a subject are provided. One embodiment provides a recombinant polypeptide having a polynucleotide-binding domain, a protein transduction domain, and a targeting domain. In a preferred embodiment, the polynucleotide-binding domain includes one or more HMG box domains.
US08927687B2 Microcrystalline Y receptor agonists
The disclosure provides microcrystals of Y receptor agonists; microcrystalline pellets of Y receptor agonists, and microcrystalline suspensions of Y receptor agonists. Pharmaceutical compositions containing these microcrystals, microcrystalline pellets, and microcrystalline suspensions have prolonged pharmacokinetic profiles making them useful for once daily or once weekly administration.
US08927685B1 Thermoset and thermoplastic compositions derived from the essential oils of herbs
A renewable chemical feedstock derived from the essential oils from herbs and other plants. In embodiments, trans-anethole are transformed into thermoset and thermoplastic compositions.
US08927684B2 Fluorinated monomers, oligomers and polymers for use in organic electronic devices
Compounds of Formula (I): (formula (I)) where: X1 and X2 are the same or different and each is independently Cl, Br, I, a substituted or unsubstituted aryl group or a substituted or unsubstituted heteroaryl group; and, Y is O, S, Se, NR1, R1C—CR2 or R1C═CR2, wherein R1 and R2 are the same or different and are each independently H or an organic group, are useful as monomers to produce oligomers or polymers that are useful in organic electronic devices.
US08927683B2 Polymerization fluid, method for producing the polymerization fluid, transparent film and transparent electrode made from the polymerization fluid
Disclosed is a polymerization fluid for electropolymerization which exhibits a reduced environmental burden and excellent economic efficiency and which can yield a conductive polymer film that has high conductivity and that is dense and highly transparent. The polymerization fluid includes at least one monomer selected from the group consisting of 3,4-disubstituted thiophenes which is dispersed as oil drops in surfactant-free water, and the polymerization fluid is transparent. The polymerization fluid can be produced by a method which includes: an addition step of adding the monomer to surfactant-free water to prepare a phase separation fluid where water and the monomer are phase-separated; a first dispersion step of irradiating the phase separation fluid with ultrasonic waves to make the monomer dispersed in the form of oil drops and thus prepare an opaque dispersion, and a second dispersion step of irradiating the opaque dispersion with ultrasonic waves having a frequency higher than that of the ultrasonic waves used in the first dispersion step to reduce the mean size of the oil drops of the monomer and thus prepare a transparent dispersion.
US08927678B2 Crystalline thermoplastic polyimide resin
A thermoplastic polyimide resin containing a repeating structural unit represented by the following formula (1) and a repeating structural unit represented by the following formula (2), a content ratio of the repeating structural unit of formula (2) with respect to the total of the repeating structural unit of formula (1) and the repeating structural unit of formula (2) being from 40 to 70% by mol: wherein R1 represents a divalent group having from 6 to 22 carbon atoms containing at least one alicyclic hydrocarbon structure; R2 represents a divalent chain aliphatic group having from 5 to 12 carbon atoms; and X1 and X2 each independently represent a tetravalent group having from 6 to 22 carbon atoms containing at least one aromatic ring.
US08927677B2 Toughening agent for epoxy resin compositions
A curable epoxy resin composition comprising (a) at least one epoxy resin; (b) at least one curing agent; and (c) at least one high molecular weight poly(propylene oxide) poiyol toughening agent; and a process for preparing the curable epoxy resin composition.
US08927674B2 Dehydrogenative silylation and crosslinking using cobalt catalysts
Disclosed herein are cobalt complexes containing terdentate pyridine di-imine ligands and their use as efficient and selective dehydrogenative silylation and crosslinking catalysts.
US08927673B2 Method for preparing a polysilsesquioxane of a controlled structure and polysilsesquioxane prepared by the same
Disclosed are a method for polymerizing polysilsesquioxane from a trialkoxysiloxane monomer, including: preparing an aqueous organic solution including a trialkoxysiloxane monomer, an organic solvent, water and a catalyst; and selectively preparing a polysilsesquioxane with a cage structure or a polysilsesquioxane with a ladder structure by adjusting the amount of the organic solvent or water in the aqueous organic solution, and a polysilsesquioxane with a cage structure or a polysilsesquioxane with a ladder structure prepared therefrom.
US08927672B2 Benzindocyanine compound for labeling substance, intermediate thereof, and method for preparing the same
The present disclosure relates to a novel benzindocyanine compound for labeling biomolecules and a method for preparing the same.
US08927668B2 Fluorinated elastic copolymer and method for its production
To provide a fluorinated elastic copolymer which is excellent in crosslinking reactivity and extrusion moldability and which is curable to obtain a rubber excellent in permanent compression set resistance, base resistance and oil resistance and particularly suitable as a covering material for electric wires. A fluorinated elastic copolymer obtained by copolymerizing tetrafluoroethylene, propylene and optionally another monomer, wherein the molar ratio (a)/(b) of repeating units (a) derived from tetrafluoroethylene to repeating units (b) derived from propylene in the fluorinated elastic copolymer is from 60/40 to 75/25, and repeating units (c) derived from said another monomer is from 0 to 10 mol % in the fluorinated elastic copolymer.
US08927665B2 Slurry phase polymerisation process
Process for polymerizing in a loop reactor an olefin monomer optionally together with an olefin comonomer in the presence of a polymerization catalyst in a diluent to produce a slurry including solid particulate olefin polymer and the diluent. The Froude number is in the range 3 to 10, the internal diameter of the loop reactor is over 600 millimeters, the solids concentration of the slurry in the loop reactor is above 20% by volume and, when the polymer produced is polyethylene and the diluent is an alkane, the solids concentration is above 40 wt % based on the total weight of the slurry.
US08927661B2 Flame retardant polycarbonate compositions, methods of manufacture thereof and articles comprising the same
Disclosed herein is a flame retardant composition comprising 10 to 90 weight percent of a linear polycarbonate; a branched polycarbonate; 10 to 70 weight percent of a polysiloxane-polycarbonate copolymer; and 1 to 20 weight percent of a phosphazene compound; were all weight percents are based on the total weight of the composition. Disclosed herein too is a method comprising blending 10 to 90 weight percent of a linear polycarbonate; a branched polycarbonate; 10 to 70 weight percent of a polysiloxane-polycarbonate copolymer; and 1 to 20 weight percent of a phosphazene compound; to form a flame retardant composition; were all weight percents are based on the total weight of the composition.
US08927656B2 Rubber composition, production method therefor and tire
Objects of the present invention are to provide a rubber composition that can obtain a rubber elastic body having small rolling resistance and excellent impact resilience and a method for producing the same, and to provide a tire having small rolling resistance and excellent impact resilience. The rubber composition of the present invention is obtained by kneading a conjugated diene polymer (A) having a group with bonding reactivity to silica only at one site of one molecule of the polymer, a polymer (B) having groups with bonding reactivity to silica at a plurality of sites of one molecule of the polymer, and a filler (C) containing silica.
US08927651B2 High-viscosity polyamide composition
A high-viscosity polyamide composition including a branched polyamide is described. Also described, is a relationship between a high-viscosity polyamide composition and a composition including a copolyamide of a statistical tree type resulting from a reaction between a multifunctional monomer including at least three reactive functions in order to form an amide function. Further described, are three reactive functions of two different types and bifunctional monomers used in the manufacture of linear polyamides. A resulting copolyamide can have a very low melt flow index relative to the linear polyamide and improved impact resistance properties. Lastly, use of such a composition for extrusion blow-molding articles is described.
US08927648B2 Surface modification of pigments and compositions comprising the same
Disclosed herein is a method of making a modified pigment, comprising: reacting, under Mitsunobu conditions: (a) a first reactant comprising a protonated nucleophile having a pKa<15, and (b) a second reactant comprising a hydroxyl-containing organic group, wherein a pigment is attached to either the first or second reactant. The method further comprises forming the modified pigment having attached an organic species comprising the nucleophile bonded to the organic group, with the net elimination of a proton and a hydroxyl. Also disclosed herein are modified pigments, which can have applications in chemical toners, inkjet ink and electrophoretic ink compositions, black matrix materials, color filters, and coatings.
US08927646B2 Polyurethane dispersion, method of producing the same, coated articles, and method for coating articles
The instant invention is a polyurethane dispersion, method of producing the same, coated articles, and method of coating articles. The polyurethane dispersion according to the instant invention comprises (a) one or more polyurethane units derived from one or more prepolymers, wherein the one or more prepolymers comprise the reaction product of one or more natural oil based polyols dissolved in dipropylene glycol dimethyl ether in the presence of one or more first surfactants with one or more isocyanates; and (b) water.
US08927640B2 Nitrile copolymer latex composition and nitrile copolymer rubber composition
A nitrile copolymer latex composition containing a latex of a nitrile copolymer rubber (A) having α,β-ethylenically unsaturated nitrile monomer units in 10 to 75 wt %, conjugated diene monomer units in 5 to 89.9 wt %, and cationic monomer units and/or monomer units able to form cations in 0.1 to 20 wt %, an inorganic filler (B) having an aspect ratio of 30 to 2,000, and a plasticizer (C) having an SP value by the HOY method of 8 to 10.2 (cal/cm3)1/2, wherein a content of said plasticizer (C) is 0.1 to 200 parts by weight with respect to said nitrile copolymer rubber (A) as 100 parts by weight is provided.
US08927635B2 Positively charged ink composition
Positively charged ink compositions, its use and method of making the same are disclosed. A disclosed example of the positively charged ink compositions includes a combination of a carrier liquid, basic pigment-loaded resin particles, a charge director and an acidic charge adjuvant.
US08927632B2 Polylactic acid based film
A polylactic acid based film includes a composition containing a polylactic acid based resin (A), a thermoplastic resin other than polylactic acid based resin (B), and a compound treated with a surface treatment agent as filler (C), the polylactic acid based resin containing a crystalline polylactic acid based resin and an amorphous polylactic acid based resin, and resin (A) accounting for 10 to 95 mass % and resin (B) accounting for 5 to 90 mass % of a combined total of 100 mass % of resin (A) and resin (B), and filler (C) accounting for 10 to 400 parts by mass per a combined total of 100 parts by mass of resin (A) and resin (B).
US08927627B2 Silicone composition for coating a flexible support intended to form a crosslinked coating having increased attachment, mechanical strength and reactivity
Crosslinkable or crosslinked silicone compositions, forming water-repellent and release coating for a flexible heat sensitive support of paper or polymer, and comprising crosslinking polyorganosiloxanes (POSs) bearing ≡Si—H units and unsaturated, preferably ≡Si-Vi, vinyl-containing POSs, capable of reacting with the crosslinker by polyaddition, in the presence of platinum in order to form the crosslinked release coating on the flexible support. The object is enabling the coating composition to crosslink instantaneously to produce, on various flexible supports (paper, e.g. glassine, or polymer, e.g. polyester such as polyethylene terephthalate PET), a crosslinked silicone coating leaving the coating machine, with excellent attachment (adhesion) and mechanical strength or cohesion—“Rub-off”—properties. The invention uses, per 100 parts by weight of silicone base, of 1 to 40 parts by weight of an additive comprising from 1 or 5 to 80% by weight of particulate filler, preferably nanoscale filler, in a silicone oil reacting with the crosslinker.
US08927625B2 Resin syrup, artificial marble containing a hardened form of the resin syrup, and a production method for the same
The present invention relates to resin syrup, which comprises a high-molecular-weight acrylic material containing a carboxyl group, and comprises a room-temperature-curing initiator and a high-temperature-curing initiator, and it also relates to an artificial marble containing a hardened form of the resin syrup, and to a production method for the same. The present invention can provide resin syrup having outstanding curing efficiency and a viscosity suitable for press molding by a process such as maturation because of the inclusion of the high-molecular-weight acrylic material containing a carboxyl group, the room-temperature-curing initiator, and the high-temperature-curing initiator, and it can provide an artificial marble containing a hardened form of the resin syrup, and a production method for the same.
US08927619B2 Color-stabilized iodopropynyl butylcarbamate
Microparticles containing an ultraviolet light absorbing polymer and 3-iodo-2-propynyl butylcarbamate (“IPBC”) resist discoloration by sunlight and other ultraviolet light sources. Methods for preparing the microparticles produce polymer-shielded, formaldehyde-free IPBC formulations which resist discoloration and leaching, and are especially useful in water-based applications. The microparticles include a polymer that absorbs light over a range of ultraviolet wavelengths associated with IPBC discoloration. The microparticles may be utilized in paints, stains, stuccoes, adhesives, and plastics, for example.
US08927617B2 Fragranced water-sensitive film
A film formed from a water-soluble polymer matrix within which is contained at least one fragrance is provided. The film is water-sensitive (e.g., water-soluble, water-dispersible, etc.) so that upon contact with a sufficient amount of water, the polymer matrix loses its integrity over time to increasingly expose the fragrance to the ambient environment for releasing its odor. The ability to incorporate a fragrance into the polymer matrix is achieved in the present invention by controlling a variety of aspects of the film construction, including the nature of the fragrance, the nature of the water-soluble polymer, the manner in which the polymer matrix and fragrance are melt processed, etc. For example, the fragrance may be injected directly into the extruder and melt blended with the water-soluble polymer. In this manner, the costly and time-consuming steps of pre-encapsulation or pre-compounding of the fragrance into a masterbatch are not required. Furthermore, to obtain a balance between the ability of the fragrance to release the desired odor during use and likewise to minimize the premature exhaustion of the odor during melt processing, the fragrance is selected to have a boiling point (at atmospheric pressure) within a certain range, such as from about 125° C. to about 350° C.
US08927616B2 Modified polymeric materials and methods of modifying polymeric materials
Methods of forming polymeric articles using plasma treated polymer resins, and orthopedic implants comprising a polymeric article wherein the polymeric article has reactive groups bonded to polymer molecules in an interior region of the polymeric article.
US08927615B2 Plasmonic assisted systems and methods for interior energy-activation from an exterior source
A method and a system for producing a change in a medium disposed in an artificial container. The method places in a vicinity of the medium at least one of a plasmonics agent and an energy modulation agent. The method applies an initiation energy through the artificial container to the medium. The initiation energy interacts with the plasmonics agent or the energy modulation agent to directly or indirectly produce the change in the medium. The system includes an initiation energy source configured to apply an initiation energy to the medium to activate the plasmonics agent or the energy modulation agent.
US08927614B2 Process for producing rigid polyurethane foams
The invention relates to a process for producing polyurethanes by reacting a) polyisocyanates with b) compounds having at least two hydrogen atoms which are reactive toward isocyanate groups, wherein the compounds b) having at least two hydrogen atoms which are reactive toward isocyanate groups comprise at least one polyether alcohol b1) which has been prepared by reaction of an aromatic amine b1a) with propylene oxide using an amine b1b) which is different from b1a) as catalyst.
US08927613B2 Cellular elastomer with little tendency toward creep at high temperatures
The present invention relates to cellular polyisocyanate polyaddition products whose density to DIN EN ISO 845 is from 200 to 800 kg/m3, and also to prepolymer composed of at least one diisocyanate (a) and of at least one polyether alcohol (b), where the at least one polyether alcohol (b) comprises the following components: (b1) aliphatic polyether alcohols whose number-average molar mass is from 300 to 1000 g/mol, (b2) aliphatic polyether alcohols whose number-average molar mass is from 2000 to 10 000 g/mol, and (b3) aliphatic polyether alcohols whose number-average molar mass is from 10 000 to 100 000 g/mol, to a process for its production, to a cellular polyisocyanate polyaddition product thus produced, and to its use as damping elements in vehicle construction.
US08927612B2 Composite having ion exchange function and preparation method and use thereof
A composite having ion exchange function, preparation method and use thereof are provided. The composite is formed by compounding ion exchange resin with fluorine-containing polymer porous membrane, wherein the nitrile groups in the ion exchange resin react with the nitrile groups grafted on the fluorine-contained polymer porous membrane to form triazine ring crosslinked structure. The composite has excellent mechanical property and gas impermeability, high ion exchange capacity and high electroconductivity.
US08927607B1 Methods of colchicine administration
The invention provides improved methods for coadministration of colchicine with drugs metabolized by CYP3A4 (anciently referred to as cytochrome P450 isozyme 3A4) or the P-glycoprotein transporter, but not both. The method enables non-toxic coadministration of colchicine and the second drug at their ordinary levels safely and effectively without reducing the dose or frequency for either drug.
US08927603B2 X-ray sterilization of liquid adhesive compositions
The invention provides a method of preparing a sterile, liquid adhesive composition in a sealed container using X-ray irradiation. The liquid adhesive compositions maintain their stability after sterilization and have an extended shelf life, making them particularly useful in the medical field.
US08927600B2 Compound for use in the treatment of peripheral neuropathies
The present invention relates to a compound of the following formula (I): or a pharmaceutically acceptable salt thereof, for use in the prevention or treatment of peripheral neuropathies.
US08927591B2 Thiochromene derivatives as HIF hydroxylase inhibitors
The present invention relates to novel compounds, methods, and compositions capable of decreasing HIF hydroxylase enzyme activity, thereby increasing the stability and/or activity of hypoxia inducible factor (HIF).
US08927590B2 Synthesis of pyrrolidine compounds
Provided are methods for the preparation of certain substituted pyrrolidine compounds, forms of (2S,4R)-1-(2-aminoacetyl)-4-benzamidopyrrolidine-2-carboxylic acid hydrochloride, and methods for preparing and using these forms.
US08927585B2 TRPV4 antagonists
The present invention relates to spirocarbamate analogs, pharmaceutical compositions containing them and their use as TRPV4 antagonists.
US08927583B2 Pesticidal composition comprising a 2-pyrdilmethylbenzamide derivative and an insecticide compound
A composition comprising at least a pyridylmethylbenzamide derivative of general formula (I) (A) and an insecticide compound (B) in a (A)/(B) weight ratio of from 1/1000 to 1000/1; a composition further comprising an additional fungicidal compound and a method for preventively or curatively combating the pests and diseases of crops by using this composition.
US08927581B2 Fungicidal N-(2-pyridylpropyl) carboxamide derivatives and their oxa, aza and thia analogues
The present invention relates to fungicide N-(2-pyridylpropyl)carboxamide derivative and its oxa, aza and thia analogs of formula (I), their process of preparation and intermediate compound for their preparation, their use as fungicides, particularly in the form of fungicidal compositions and methods for the control of phytopathogenic fungi of plants using these compounds or their compositions. wherein A, T, W, X, n and Z3 to Z7 represent various substituents.
US08927579B2 Male contraceptive
A compound having formula I. R1, R2, R3 and R4 are independently H or lower alkyl. R5 is aryl, heteroaryl, cycloalkyl, heterocycloalkyl, aryloxy, heteroaryloxy, cycloalkyloxy, heterocycloalkyloxy, arylamino, heteroarylamino, cycloalkylamino, heterocycloalkyl amino, arylthio, heteroarylthio, cycloalkylthio, heterocycloalkylthio, or cyclic olefin, any of which may be substituted or non-substituted; or substituted alkyl, substituted alkyl oxy or substituted alkyl amino wherein the substituent is an aryl, a heteroaryl, a cycloalkyl, a heterocycloalkyl or a cyclic olefin, any of which may be substituted or non-substituted. X is C or N. n and p are independently whole numbers selected from 0, 1 and 2. (CH2)n and (CH2)p may be substituted or non-substituted. Ar1 and Ar2 are independently aryl or heteroaryl groups which may be substituted or non-substituted. Certain specific compounds are excluded.The compounds can be used in a medicament or a method for the reduction or prevention of the emission of sperm, or for the reduction or prevention of transmission of viral agents transmitted in seminal fluid.
US08927572B2 Crystal form I of salt of a dipeptidyl peptidase-IV inhibitor and preparation method and use thereof
The present invention relates to the crystal form I of salt of a dipeptidyl peptidase-IV inhibitor, and the preparation method and use thereof. In particular, it relates to the crystal form I of dihydrochloride salt of the compound (R)-2-[[7-(3-aminopiperidin-1-yl)-3,5-dimethyl-2-oxo-2,3-dihydro-1H-imidazo[4,5-b]pyridin-1-yl]methyl]benzonitrile represented by formula (1), which is a dipeptidyl peptidase-IV inhibitor, and the preparation method and use thereof. The crystal form I of dihydrochloride salt of the dipeptidyl peptidase-IV inhibitor represented by formula (1) is characterized in that it has characteristic peaks at 8.7±0.2°, 19.4±0.2°, 23.5±0.2° and 27.2±0.2° in X-ray powder diffraction indicated by an angle 2θ (°) using Cu—Kα irradiation.
US08927570B2 1-naphthyl-or 1-dihydroacenaphthenyl-pyrido[B]indoles and uses thereof in treating cancers
Provided are 1-aryl or 1-heteroaryl substituted beta-carboline compounds or indole analogs thereof having the structure: where X is NH, N—C1-C4 alkyl, S, or O; R1 is 1-naphthyl or 1-dihydroacenaphthenyl, each optionally substituted with a halogen; and R2, R3, R4, R5, R6, and R7 are independently H H, OH, halogen, CN, C1-C4 alkyl, C1-C4 alkoxy, C1-C4 haloalkoxy, —C(O)OC1-C4 ester, —C1-C4—SO2—NH—C1-C4 sulfonamide, or phenyl with the proviso that X is NH, R1 is 1-naphthyl or 1-naphthyl substituted with a halogen and one of R5, R6, or R7 is C1-C4 alkoxy, then R2, R3, R4, R5, R6, and R7 are independently H, OH, halogen, CN, C1-C4 haloalkoxy, —C(O)OC1-C4 ester, —C1-C4—SO2—NH—C1-C4 sulfonamide, or phenyl such that at least two of R2, R3, R4, R5, R6, and R7 are other than H. Also provided are methods for inhibiting proliferation of cells associated with a cell proliferative disease by contacting the cell with the compounds provided herein.
US08927566B2 Norepinephrine and selective serotonin receptor blocker and use thereof
The present invention relates to a norepinephrine and selective serotonin receptor blocker and the use thereof. The norepinephrine and selective serotonin receptor blocker is a compound of formula I, or isomers, pharmaceutically acceptable salts or solvates thereof, wherein R1 is selected from the group consisting of C1-6 alkyl, C1-6 alkoxy, C6-10 aralkyl, C6-10 arylalkoxy, C1-6 haloalkyl and C1-6 haloalkoxy; and R2 is one or more groups each independently selected from the group consisting of hydrogen, halogen, C1-6 alkyl, C1-6 alkoxy, nitro, cyano, amino, hydroxyl, C1-6 haloalkyl, and C1-6 haloalkoxy. R3 is one or more groups each independently selected from the group consisting of hydrogen, halogen, C1-6 alkyl, C1-6 alkoxy, nitro, cyano, amino, hydroxyl, C1-6 haloalkyl, and C1-6 haloalkoxy. The compound of the present invention is effective norepinephrine and selective serotonin receptor blocker.
US08927565B2 Compositions for veterinary and medical applications
Compositions including polymeric dialdehydes and compounds of where R1, R2, R7, R8, R9, and R10 may be the same or different and are selected from H, CH3, OH, OCH3, C2H5, OC2H5OCH2Ph, OCH2PhNO2, F or Cl; R3, R4, R5, R6 may be the same or different and are selected from H, CH3, OCH3, C2H5, OC2H5OCH2Ph, OCH2PhNO2, F or Cl, or R5 and R6 are the same or different and are selected from H, CH3, OCH3, C2H5, OC2H5OCH2Ph, OCH2PhNO2, F or Cl and R3 and R4 together are ═O, or R4 and R6 are the same or different and are selected from H, CH3, OCH3, C2H5, OC2H5OCH2Ph, OCH2PhNO2, F or Cl and R3 and R5 together form a double bond or are ═O, or R3 and R4, are the same or different and are selected from H, CH3, OCH3, C2H5, OC2H5OCH2Ph, OCH2PhNO2, F or Cl and R5 and R6 together are ═O; R11 and R12 together form ═CH2, or R11 and R12 may be the same or different and are independently selected from the group consisting of H, CH3, CH2CH3 and CH2CH2CH3; and X is selected from the group consisting of Cl, Br, SO4, I and R13COO, where R13 is CH3 or poly acids, for the treatment of gastrointestinal functional disorders or related conditions as well as for the promotion of general health and weight gain in animals including humans.
US08927559B2 Quinazolinone-type compounds as CRTH2 antagonists
This application provides for compounds of the formula Formula I or a pharmaceutically acceptable salt thereof, wherein the individual variables are defined herein, as well as processes to prepare these compounds, pharmaceutical compositions comprising the same and their use in treating disease state associated with the CRTH2 receptor.
US08927558B2 Methods for detecting and reducing impurities of Lapatinib and salts thereof
Impurities of lapatinib such as N-{3-chloro-4-[(2-fluorobenzyl)oxy]phenyl}-6-[5-({[2-(methylsulfonyl)ethyl]amino}methyl)furan-2-yl]quinazoline-4-amine compound of formula (I) or a salt thereof: and analytical methods for identifying and quantifying such impurities of Lapatinib and salts thereof are provided. Also provided is Lapatinib containing less than about 0.05 percent of this and related impurities and methods for preparing such pure forms of Lapatinib.
US08927555B2 Thieno- and furo-pyrimidine modulators of the histamine H4 receptor
Thieno- and furo-pyrimidine compounds are described, which are useful as H4 receptor modulators. Such compounds may be used in pharmaceutical compositions and methods for the modulation of histamine H4 receptor activity and for the treatment of disease states, disorders, and conditions mediated by H4 receptor activity, such as inflammation.
US08927549B2 Adamantyl benzamide derivatives
Embodiments of the present invention provide adamantyl benzamide derivatives and pharmaceutical compositions comprising adamantyl benzamide derivatives. Methods of use of such compounds and compositions to modulate the activity of 11β-hydroxysteroid dehydrogenase type 1 (11βHSD1) in a subject are also provided.
US08927548B2 Triazole compounds that modulate HSP90 activity
The present invention relates to substituted triazole compounds and compositions comprising substituted triazole compounds. The invention further relates to methods of inhibiting the activity of Hsp90 in a subject in need thereof and methods for preventing or treating hyperproliferative disorders, such as cancer, in a subject in need thereof comprising administering to the subject a substituted triazole compound of the invention, or a composition comprising such a compound.
US08927546B2 Therapeutic piperazines
The invention includes a compound of formula I: wherein R1, Y, A, n, R4 and Z have any of the values described herein, as well as salts of such compounds, compositions comprising such compounds, and therapeutic methods that comprise the administration of such compounds. The compounds are inhibitors of PDE4 function and are useful for improving cognitive function and/or treating cognitive disorders or impairment, traumatic and/or ischemic injuries of the central and peripheral nervous system and/or psychiatric disorders in animals, especially humans.
US08927544B2 Benzofuran-2-sulfonamides derivatives as chemokine receptor modulators
The present invention relates to benzofuran-2-sulfonamide derivatives with the following formula: or pharmaceutically acceptable salts thereof. The derivatives are useful as modulators of chemokine receptors.
US08927542B2 Bicyclic antibiotics
The antibacterial compound of formula I wherein X1, X3; X4 and X6, each independently of the others, represents a nitrogen atom or CR2, with the proviso that at least one of X1, X3; X4 and X6 represents a nitrogen atom; X2 represents C—H, C—(C1-C6alkyl), C—(C1-C6alkoxy), C-halogen, C—COOH; X5 represents C—H or C—(C1-C6alkyl), C-halogen; A1, A2, A3, R1 and R4 represent various substituents, G represents aryl or heteroaryl, which is unsubstituted or substituted which compounds show good activity against pathogenic bacteria.
US08927541B2 Tricyclic antibiotics
The present invention relates to antibacterial compounds of formula I: wherein all variable substituents are defined as described herein, which are useful for the treatment of bacterial infections.
US08927538B2 Carbazole linked pyrrolo[2,1-c][1,4]benzodiazefine hybrids as potential anticancer agents and process for the preparation thereof
The present invention provides a compound of general formulae A useful as potential antitumour agents against human cancer cell lines. The present invention further provides a process for the preparation of pyrrolo[2, 1-c][1,4]benzodiazepine hybrids of general formulae 6a-g, 10a-o, 14a-g and 18a-o.
US08927535B2 Cyclopropyl-fused-1,3-thiazepines as BACE1 and/or BACE2 inhibitors
The present invention provides cyclopropyl-fused-1,3-thiazepines of formula I having BACE1 and/or BACE2 inhibitory activity, their manufacture, pharmaceutical compositions containing them and their use as therapeutically active substances. The active compounds of the present invention are useful in the therapeutic and/or prophylactic treatment of e.g. Alzheimer's disease and type 2 diabetes.
US08927532B2 Therapeutic agent and diagnostic agent for mitochondrial dysfunction brain diseases
To provide a therapeutic agent and a diagnostic agent for mitochondrial dysfunction brain diseases including cerebral infarction as a representative.A therapeutic agent for a mitochondrial dysfunction brain disease, which comprises (A) δ-aminolevulinic acid represented by the formula (1), a derivative thereof, or a salt thereof and (B) an iron compound in combination. R2R1NCH2COCH2CH2COR3  (1) wherein R1 and R2 each independently represents a hydrogen atom, an alkyl group, an acyl group, an alkoxycarbonyl group, an aryl group, or an aralkyl group; and R3 represents a hydroxy group, an alkoxy group, an acyloxy group, an alkoxycarbonyloxy group, an aryloxy group, an aralkyloxy group, or an amino group.
US08927526B2 Fused aromatic PTP-1B inhibitors
The invention encompasses the novel class of compounds represented by the formula below, which are inhibitors of the PTP-1B enzyme. The invention also encompasses pharmaceutical compositions which include the compounds shown (Formula I) above and methods of treating or preventing PTP-1B mediated diseases, including diabetes.
US08927523B2 Compound sea cucumber preparation and manufacturing method thereof
A sea cucumber preparation and manufacturing method thereof, comprising steps as follows: put the cut and well-cleaned fresh sea cucumber or soaked sea cucumber into an airtight container; at 70˜130° C., gelatinate for 1 min˜20 h, freeze-dry till the water content is less than 10 wt %, then sequentially carry out coarse, ultra-micro and nanometer crushing till the fineness reaches 10˜1000 nm. Add water into the sea cucumber nanometer powder to carry out proteinase enzymolysis, after the enzymolysis is finished, inactivate the proteinase, separate and take the supernatant and dry to get nanometer sea cucumber extract. Evenly mix the extract with panax pseudo-ginseng saponins extract at the proportion of 99˜70%:1˜30%. The content of the sea cucumber polysaccharide in the mixture is 2.5˜8.0 wt %, the content of panax pseudo-ginseng saponins is 0.3˜21.0 wt %. The compound preparation has complementary and synergistic effects on pharmacological effect. The side effects of single preparation can be eliminated through the compound preparation, the pharmacological functions of the sea cucumber or panax pseudo-ginseng single preparation are greatly enhanced, and can be used for anti-coagulation, diabetes and other various medicinal purposes.
US08927520B2 Antibacterial compounds
The present invention relates to compounds of formula (I): wherein Rj, R2, R3, R4, Xi, X2, X3 and Z are as defined in claim 1. The compounds are useful in the prevention and/or treatment of bacterial infections.
US08927518B1 Method for the treatment of malignancies
A method of treating cancerous tumors is presented herein. The method includes injecting an effective dose of a plasmid encoded for IL-12, B7-1 or IL-15 into a cancerous tumor and subsequently administering at least one high voltage, short duration pulse to the tumor. The electroporation pulses may be administered at at least 700V/cm for a duration of less than 1 millisecond. The intratumor treatments with electroporation may be administered in at least a two-treatment protocol with the time between treatments being about 7 days. The intratumor treatments with electroporation may be administered in a three-treatment protocol with a time of four days between the first and second treatments and a time of three days between the second and third treatments. It was found that the intratumor treatments using electroporation not only resulted in tumor regression but also induced an immune memory response which prevented the formation of new tumors.
US08927515B2 Methods and compositions for the specific inhibition of androgen receptor by double-stranded RNA
This invention relates to compounds, compositions, and methods useful for reducing AR target RNA and protein levels via use of dsRNAs, e.g., Dicer substrate siRNA (DsiRNA) agents.
US08927514B2 Recombinant adeno-associated vectors for targeted treatment
Novel adeno-associated virus (AAV) vectors in nucleotide and amino acid forms and uses thereof are provided. The isolates show specific tropism for certain target tissues, such as blood stem cells, liver, heart and joint tissue, and may be used to transduce stem cells for introduction of genes of interest into the target tissues. Certain of the vectors are able to cross tightly controlled biological junctions, such as the blood-brain barrier, which open up additional novel uses and target organs for the vectors, providing for additional methods of gene therapy and drug delivery.
US08927511B2 Treatment of vascular endothelial growth factor (VEGF) related diseases by inhibition of natural antisense transcript to VEGF
Oligonucleotide compounds modulate expression and/or function of Vascular Endothelial Growth Factor (VEGF) polynucleotides and encoded products thereof. Methods for treating diseases associated with Vascular Endothelial Growth Factor (VEGF) comprise administering one or more Oligonucleotide compounds designed to inhibit the VEGF natural antisense transcript to patients.
US08927508B2 Antibody production elicited by a DNA vaccine delivered by electroporation
There are provided methods of generating antibodies in a mammal against recombinant antigens using DNA plasmids capable of expressing said antigens in cells of said mammal, comprising: injecting into tissue of said mammal a DNA plasmid comprising an encoding sequence operably linked to a promoter, electroporating said tissue with an electroporation device capable of delivering an electrical pulse effective to electroporate cells of said tissue to allow entry of said DNA plasmid and expression of said antigen, and allowing said mammal to respond to said expressed antigen in order to generate antibodies to said antigen. Furthermore, there are provided methods of isolating antibodies specific against desired antigens wherein said antibodies are generated in a mammal using DNA plasmids capable of expressing said antigens.
US08927506B2 Acetates of 2-deoxy monosaccharides with anticancer activity
Novel compounds and methods of using the same to inhibit glycolysis and treat cancer and other diseases are provided herein.
US08927498B2 Compositions and methods useful in enhancement of memory
Compounds derived from a transduction complex that enhance memory in mammals and methods of enhancing memory using said compounds are disclosed.
US08927495B1 Use of GnRH and analogs thereof for the prevention and treatment of pet ferret adrenocortical hyperplasia
Adrenocortical disease (ACD) in ferrets develops as a result of the effect of increased concentration of Luteinizing Hormone (LH) on adrenal LH receptors. This increase in LH often results from the neutering of male or female ferrets. Neutered ferrets have no negative feedback of the ovarian or testicular hormone and as a result LH is elevated 3 to 10 times normal. Elevated LH may be prevented and/or treated by injection of GnRH vaccine. Administration of GnRH produces antibodies to endogenous GnRH. The GnRH-anti-GnRH immune-complex is ineffective in stimulating the release of LH and FSH in the anterior pituitary resulting drop in concentration of LH in the systemic circulation. This reduction in LH significantly reduces the occurrence or clinical symptoms of ACD therein. Moreover, treatment of ferrets with the GnRH provides long term relief from ACD for a period of a year or more.
US08927492B2 Fibroblast growth factor 21 proteins
This present invention relates to pharmacologically potent and stable human fibroblast growth factor 21 (FGF21) proteins, pharmaceutical compositions comprising FGF21 proteins, and methods for treating type 2 diabetes, obesity, dyslipidemia, and/or metabolic syndrome using such proteins.
US08927490B2 Systems and methods to estimate nutritional needs of human and other patients
Systems, techniques and methods for estimating the metabolic state or flux, e.g., the body energy state (“BES”) of a patient, are disclosed. The BES provides deep insight into the nutritional needs of the patient, thus allowing for a sort of exquisite glycemic control with regard to the patient. The invention discloses systems and methods for estimating fractional gluconeogenesis, which is the % of glucose production that comes from gluconeogenesis (“GNG”), as opposed to glycogenolysis (“GLY”), the other form of glucose production. Nutritional formulations, materials, cocktails and methods for feeding patients by parenteral and other means are disclosed. The amount, type and rate of such nutritional feeding are typically based upon the above estimating. The invention discloses formulations that contain labels, such as deuterium, for medical diagnostics, such as for estimating BES and fractional gluconeogenesis. The invention is suitable for any sort of patient, including those who are injured, such as with traumatic brain injury, ill, or have other conditions that stress the metabolic system.
US08927488B2 Pegylated C-peptide
The present invention relates to modified forms of C-peptide, and methods for their use. In one aspect, the modified forms of C-peptide comprise PEGylated C-peptide derivatives comprising at least one PEG group attached to the N-terminus, which exhibit superior pharmacokinetic and biological activity in vivo.
US08927476B2 Aqueous alkaline cleaning compositions and methods of their use
Aqueous alkaline composition free from organic solvents and metal ion-free silicates, the said compositions comprising (A) a thioamino acid having at least one primary amino group and at least one mercapto group, (B) a quaternary ammonium hydroxide, (C) a chelating and/or corrosion inhibiting agent selected from the group consisting of aliphatic and cycloaliphatic amines having at least two primary amino groups, and aliphatic and cycloaliphatic amines having at least one hydroxy group, (D) a nonionic surfactant selected from the group of acetylenic alcohols, alkyloxylated acetylenic alcohols and alkyloxylated sorbitan monocarboxylic acid mono esters; the use of the alkaline composition for the processing of substrates useful for fabricating electrical and optical devices; and a method for processing substrates useful for fabricating electrical and optical devices making use of the said aqueous alkaline composition.
US08927473B2 Color indication of effectiveness of immiscible liquid suspension
A two-part liquid product, the first of which comprises a first solvent and a first dissolved dye; and the second of which comprises a second solvent and a second dissolved dye. The two solvents are immiscible. The first dye is insoluble in the second solvent, and the second dye is insoluble in the first solvent. Each dye is a different color than the other. Initially, when placed in a single container, the two parts form two separate different colored layers that do not mix. Shaking the container produces a temporary micro-emulsion. The emulsion has a new color representing the combination of the colors of the two component layers. This combination color indicates to the user that an emulsion exists and that the product is effective. The component materials are selected so as to produce a stable emulsion for between five to twenty minutes before separation.
US08927472B2 Lubricant oil compositions
Compositions comprise first antioxidants and first additives, such as, a surface additives, performance enhancing additives and lubricant protective additives and optionally second additives and/or second antioxidants. The compositions are useful to improve lubricants, lubricant oils and other lubricant materials. The compositions and methods generally provide longer shelf lives, increased oxidative resistance, improved quality and/or enhanced performance to lubricants or lubricant oils.
US08927470B2 Process and apparatus for preparing a soap concentrate, a lubricating composition, and combinations thereof
The invention provides for a process and apparatus for preparing a soap concentrate, including: (a) introducing feed components to a first feeding zone; (b) first reacting in a first reacting zone; (c) first venting in a first venting zone; and (d) cooling in a cooling zone. The process may further include, after (c) and before (d): (i) continued reacting in a continued reacting zone; and (ii) second venting in a second venting zone. The invention also provides for a process and apparatus for preparing a lubricating composition comprising: (aa) introducing a soap concentrate and a base oil to a lubricating composition feeding zone; (bb) dispersing the soap concentrate in a lubricating composition dispersing zone; (cc) mixing the soap concentrate and the base oil in a lubricating composition mixing zone; and (dd) cooling in a lubricating composition cooling zone.
US08927468B2 Spray dried emulsifier compositions, methods for their preparation, and their use in oil-based drilling fluid compositions
Spray dried emulsifier compositions are described, which have desirable emulsifying and wetting characteristics. Among other advantages, the solid particulate emulsifier compositions greatly reduce transportation costs and simplify the logistics and environmental concerns associated with shipping large volumes of solvent-containing liquids. The emulsifier comprises (1) a carboxylic acid terminated fatty amine condensate or (2) a modified tall oil or (3) a blend of (1) and (2) that is converted to its alkali or alkaline earth metal salt and spray dried.
US08927467B2 Method for preventing calcium citrate precipitation during citric acid acidizing treatments
Methods of preventing precipitation of calcium citrate and iron-based scale during acidizing treatments and related compositions are provided as embodiments of the present invention. The acidizing treatment fluid includes citric acid and tetra-salts of EDTA.
US08927463B2 Sensitive high throughput method for DNA damage and repair
A high throughput method and apparatus for rapidly screening a plurality of genotoxicants to determine the degree and type of genotoxicity are provided.
US08927462B2 Method for identifying HLA complexes associated with adverse drug reactions
A method for identifying from an HLA library an HLA complex that specifically binds to a compound. This method can be relied on to assess whether a compound is likely to induce an adverse drug reaction and, if so, in which human population.
US08927460B2 Biocide compositions comprising derivatives of pyroglutamic acid
Described are agrochemical compositions, comprising (a) esters and/or amides of pyroglutamic acid, and (b) biocides. The compositions are clear and exhibit an improved stability even when stored at temperatures between 5° and 40° C. over a longer period.
US08927458B2 Herbicide triazolylpyridine ketones
Triazolylpyridine ketones expressed by the following formula (1) and use thereof as herbicides.
US08927455B2 Single-step precipitation method of producing magnesia-zirconia complex carrier for catalyst for oxidative dehydrogenation of n-butane, magnesium orthovanadate catalyst supported on magnesia-zirconia complex carrier, and method of producing n-butene and 1,3-butadiene using said catalyst
The present invention discloses a method of producing a magnesia-zirconia complex carrier for a catalyst for oxidative dehydrogenation of n-butane through a single-step precipitation process wherein the oxidative dehydrogenation of n-butane is to produce n-butene and 1,3-butadiene from n-butane; a method of producing a magnesium orthovanadate catalyst supported by thus prepared magnesia-zirconia complex carrier; and a method of producing n-butene and 1,3-butadiene using said catalyst.
US08927454B2 Exhaust gas-purifying catalyst
An exhaust gas-purifying catalyst includes a support provided with one or more through-holes through which exhaust gas flows, and a catalytic layer supported by the support and containing an oxygen storage material. The exhaust gas-purifying catalyst includes a first section to which the exhaust gas is supplied, and a second section to which the exhaust gas having passed through the first section is supplied. The catalytic layer includes a layered structure of a first catalytic layer containing platinum and/or palladium and a second catalytic layer containing rhodium in the first catalytic section and further includes a third layer containing rhodium in the second section. The second section is smaller in oxygen storage material content per unit volumetric capacity than the first section.
US08927452B2 Method for producing a shell catalyst and corresponding shell catalyst
The present invention relates to a method for producing a shell catalyst which comprises a porous shaped catalyst support body with an outer shell in which at least one catalytically active species is present. In order to provide a shell catalyst production method by means of which shell catalysts can be produced, said shell catalysts having, over a comparatively large region of their shell thickness, a substantially uniform concentration of catalytically active species and having a substantially uniform shell thickness, what is proposed is a method using an device which is designed to generate, by means of a process gas, a fluid bed of shaped catalyst support bodies in which the shaped catalyst support bodies circulate elliptically or toroidally, preferably toroidally, comprising the steps of charging the device with shaped catalyst support bodies and generating a shaped catalyst support body fluid bed by means of a process gas, the shaped catalyst support bodies circulating elliptically or toroidally in the fluid bed, preferably toroidally; impregnating an outer shell of the shaped catalyst support body with a catalytically active species or precursor thereof by spraying the shaped catalyst support bodies circulating elliptically or toroidally in the fluid bed with a solution comprising a catalytically active species or a precursor thereof; drying the shaped catalyst support bodies sprayed with the solution.
US08927445B2 Sealing agent with low softening temperature useful in the preparation of electronic devices
The invention includes a composition for sealing agent, generally in the form of glass frit, lead-free, comprising by weight over the total weight of the composition: 30-80% Bi2O3; 2-10% ZnO; 2-10% B2O3; 0-5% Na2O; 1-10% SiO2; 1-8% Al2O3; 0-7% BaO; and 0-8% MgO. The composition for sealing agent as defined above can be added with a filler in a quantity up to 20% by weight over the total weight of the resulting mixture. The invention also includes a sealing paste containing the composition for sealing agent, the optional filler, an organic binder and optionally an organic solvent. The invention also includes methods for producing and using the composition for sealing agent and the sealing paste, as well as an electronic device sealed with the sealing paste.
US08927440B2 Film deposition apparatus and method of depositing film
A film deposition apparatus that laminates layers of reaction product by repeating cycles of sequentially supplying process gases that mutually reacts in a vacuum atmosphere includes a turntable receiving a substrate, process gas supplying portions supplying mutually different process gases to separated areas arranged in peripheral directions, and a separation gas supplying portion separating the process gases, wherein at least one process gas supplying portion extends between peripheral and central portions of the turntable and includes a gas nozzle discharging one process gas toward the turntable and a current plate provided on an upstream side to allow the separation gas to flow onto its upper surface, wherein a gap between the current plate and the turntable is gradually decreased from a central side of the turntable to a peripheral side of the turntable, and the gap is smaller on the peripheral side by 1 mm or greater.
US08927435B2 Load lock having secondary isolation chamber
A load lock includes a chamber including an upper portion, a lower portion, and a partition between the upper portion and the lower portion, the partition including an opening therethrough. The load lock further includes a first port in communication with the upper portion of the chamber and a second port in communication with the lower portion of the chamber. The load lock includes a rack disposed within the chamber and a workpiece holder mounted on a first surface of the rack, wherein the rack and the workpiece holder are movable by an indexer that is capable of selectively moving wafer slots of the rack into communication with the second port. The indexer can also move the rack into an uppermost position, at which the first surface of the boat and the partition sealingly separate the upper portion and the lower portion to define an upper chamber and a lower chamber. Auxiliary processing, such as wafer pre-cleaning, or metrology can be conducted in the upper portion.
US08927433B2 Conductive via hole and method for forming conductive via hole
Provided is a technology for forming a conductive via hole to implement a three dimensional stacked structure of an integrated circuit. A method for forming a conductive via hole according to an embodiment of the present invention comprises: filling inside of a via hole structure that is formed in one or more of an upper portion and a lower portion of a substrate with silver by using a reduction and precipitation of silver in order to connect a plurality of stacked substrates by a conductor; filling a portion that is not filled with silver inside of the via hole structure by flowing silver thereinto; and sublimating residual material of silver oxide series, which is generated during the flowing, on an upper layer inside of the via hole structure filled with silver.
US08927431B2 High-rate chemical vapor etch of silicon substrates
Methods of etching a silicon substrate at a high rate using a chemical vapor etching process are provided. A silicon substrate may be etched by heating the silicon substrate in a process chamber and then flowing hydrochloric acid and a germanium-carrying compound into the process chamber. The substrate may be heated to at least 700° C. The hydrochloric acid flow rate may be at least approximately 100 (standard cubic centimeters per minute) sccm. In some embodiments, the hydrochloric acid flow rate may be between approximately 10 slm and approximately 20 standard liters per minute (slm). The germanium-carrying compound flow rate may be at least approximately 50 sccm. In some embodiments, the germanium-carrying compound flow rate may be between approximately 100 sccm and approximately 500 sccm. The etching may extend fully through the silicon substrate.
US08927430B2 Overburden removal for pore fill integration approach
In one exemplary embodiment of the invention, a method includes: providing a structure having a first layer overlying a substrate, where the first layer includes a dielectric material having a plurality of pores; applying a filling material to a surface of the first layer; after applying the filling material, heating the structure to enable the filling material to at least partially fill the plurality of pores, where heating the structure results in residual filling material being left on the surface of the first layer; and after heating the structure, removing the residual filling material by applying a solvent wash.
US08927429B2 Chemical mechanical polishing (CMP) composition comprising a specific heteropolyacid
A chemical mechanical polishing (CMP) composition comprising a specific heteropolyacid Abstract A chemical-mechanical polishing (CMP) composition comprising: (A) inorganic particles, organic particles, or a mixture thereof, (B) a heteropolyacid of the formula HaXbPsMOyVzOc wherein X=any cation other than H 80 and a>0 (formula I) or a salt thereof, and, (C) an aqueous medium.
US08927427B2 Anticipatory implant for TSV
A method including introducing a dopant into a region of a substrate, etching a deep trench in the substrate through the region, gettering impurities introduced during etching of the deep trench using a pentavalent ion formed from a reaction between an element of the substrate and the dopant, wherein the charge of the pentavalent ion attracts the impurities, and filling the deep trench with a conductive material.
US08927425B1 Self-aligned patterning technique for semiconductor device features
A method for fabricating a semiconductor device utilizing a plurality of masks and spacers. The method includes forming parallel first trenches in a substrate using a first lithographic process. The substrate includes sidewalls adjacent to the parallel first trenches. Forming first spacers adjacent to the sidewalls. Removing the sidewalls, which in part includes using a second lithographic process. Forming second spacers adjacent to the first spacers, resulting in spacer ridges. Etching portions of the substrate between the spacer ridges resulting in second trenches.
US08927419B2 Chip comprising an integrated circuit, fabrication method and method for locally rendering a carbonic layer conductive
A method can be used for locally rendering a carbonic isolating layer conductive. In one embodiment, a laser beam is directed onto the carbonic isolating layer so as to convert amorphous carbon of the carbonic isolating layer into graphite-like carbon. In another embodiment, the carbonic layer is heated so as to form a conducting portion of the layer so that a lateral path through the conducting portion connects two circuit elements of the integrated circuit.
US08927415B2 Graphene barrier layers for interconnects and methods for forming the same
Embodiments described herein provide interconnect barrier layers and methods for forming such barriers. A dielectric body having a trench formed in a surface thereof is provided. A first layer is formed above the dielectric body within the trench. The first layer includes amorphous carbon. A second layer is formed above the first layer. The second layer includes a metal. The dielectric body, the first layer, and the second layer are heated to convert at least some of the amorphous carbon to graphene.
US08927410B2 Methods of forming through substrate interconnects
A method of forming a through substrate interconnect includes forming a via into a semiconductor substrate. The via extends into semiconductive material of the substrate. A liquid dielectric is applied to line at least an elevationally outermost portion of sidewalls of the via relative a side of the substrate from which the via was initially formed. The liquid dielectric is solidified within the via. Conductive material is formed within the via over the solidified dielectric and a through substrate interconnect is formed with the conductive material.
US08927409B2 High-k transistors with low threshold voltage
An apparatus includes a wafer annealing tool and a plurality of electrodes coupled to the wafer annealing tool, wherein the electrodes are configured to be in physical contact with a wafer so that, when the wafer is annealed, a negative electrical bias is formed across one or more gate stacks of the wafer.
US08927406B2 Dual damascene metal gate
A method for fabricating a dual damascene metal gate includes forming a dummy gate onto a substrate, disposing a protective layer on the substrate and the dummy gate, and growing an expanding layer on sides of the dummy gate. The method further includes removing the protective layer, forming a spacer around the dummy gate, and depositing and planarizing a dielectric layer. The method further includes selectively removing the expanding layer, and removing the dummy gate.
US08927403B2 Selective deposition of noble metal thin films
Processes are provided for selectively depositing thin films comprising one or more noble metals on a substrate by vapor deposition processes. In some embodiments, atomic layer deposition (ALD) processes are used to deposit a noble metal containing thin film on a high-k material, metal, metal nitride or other conductive metal compound while avoiding deposition on a lower k insulator such as silicon oxide. The ability to deposit on a first surface, such as a high-k material, while avoiding deposition on a second surface, such as a silicon oxide or silicon nitride surface, may be utilized, for example, in the formation of a gate electrode.
US08927399B2 Localized implant into active region for enhanced stress
Methods for enhancing strain in an integrated circuit are provided. Embodiments of the invention include using a localized implant into an active region prior to a gate etch. In another embodiment, source/drain regions adjacent to the gates are recessed to allow the strain to expand to full potential. New source/drain regions are allowed to grow back to maximize stress in the active region.
US08927397B2 Diode structure and method for gate all around silicon nanowire technologies
A method of fabricating an electronic device includes the following steps. A SOI wafer is provided having a SOI layer over a BOX. At least one first/second set of nanowires and pads are patterned in the SOI layer. A conformal gate dielectric layer is selectively formed surrounding a portion of each of the first set of nanowires that serves as a channel region of a transistor device. A first metal gate stack is formed on the conformal gate dielectric layer surrounding the portion of each of the first set of nanowires that serves as the channel region of the transistor device in a gate all around configuration. A second metal gate stack is formed surrounding a portion of each of the second set of nanowires that serves as a channel region of a diode device in a gate all around configuration.
US08927394B2 Manufacturing method of an active device substrate
An active device substrate includes a flexible substrate, an inorganic de-bonding layer, and at least one active device. The flexible substrate has a first surface and a second surface opposite to the first surface, wherein the first surface is a flat surface. The inorganic de-bonding layer covers the first surface of the flexible substrate, and the material of the inorganic de-bonding layer is metal, metal oxide or combination thereof. The active device is disposed on or above the second surface of the flexible substrate.
US08927387B2 Robust isolation for thin-box ETSOI MOSFETS
A thin BOX ETSOI device with robust isolation and method of manufacturing. The method includes providing a wafer with at least a pad layer overlying a first semiconductor layer overlying an oxide layer overlying a second semiconductor layer, wherein the first semiconductor layer has a thickness of 10 nm or less. The process continues with etching a shallow trench into the wafer, extending partially into the second semiconductor layer and forming first spacers on the sidewalls of said shallow trench. After spacer formation, the process continues by etching an area directly below and between the first spacers, exposing the underside of the first spacers, forming second spacers covering all exposed portions of the first spacers, wherein the pad oxide layer is removed, and forming a gate structure over the first semiconductor wafer.
US08927384B2 Methods of fabricating a semiconductor memory device
A method of fabricating a semiconductor memory device includes forming a hard mask pattern using a damascene method on a lower mold layer stacked on a substrate and etching the lower mold layer using the hard mask pattern as an etch mask to define a protrusion under the hard mask pattern. A support pattern is formed on a top surface of the etched lower mold layer, the top surface of the etched lower mold layer being located at a lower level than a top surface of the protrusion. A lower electrode supported by the support pattern is formed.
US08927383B2 Multilayer heterostructures for application in OLEDs and photovoltaic devices
This invention relates to a supported polymer heterostructure and methods of manufacture. The heterostructure is suitable for use in a range of applications which require semiconductor devices, including photovoltaic devices and light-emitting diodes.
US08927382B2 Photo-semiconductor device and method of manufacturing the same
A method of manufacturing a photo-semiconductor device that has a photoconductive semiconductor film provided with electrodes and formed on a second substrate, the semiconductor film being formed by epitaxial growth on a first semiconductor substrate different from the second substrate, the second substrate being also provided with electrodes, and the electrodes of the second substrate and the electrodes of the photoconductive semiconductor film being held in contact with each other.
US08927379B2 Method to bridge extrinsic and intrinsic base by selective epitaxy in BiCMOS technology
A method of forming a heterojunction bipolar transistor. The method includes providing a structure comprising at least an intrinsic base region and an emitter pedestal region. A stack is formed on the intrinsic base region. The stack comprises a polysilicon layer and a top sacrificial oxide layer. A trench is formed in the structure. The trench circumscribes the intrinsic base region and the stack. An extrinsic base is formed at two regions around the stack. The extrinsic base is formed by a selective epitaxial growth process to create a bridge over the trench. The bridge connects the two regions. An opening is provided in the stack. The opening exposes a portion of the intrinsic base region. An emitter is formed in the opening.
US08927378B2 Trench silicide contact with low interface resistance
An electrical structure is provided that includes a dielectric layer present on a semiconductor substrate and a via opening present through the dielectric layer.An interconnect is present within the via opening. A metal semiconductor alloy contact is present in the semiconductor substrate. The metal semiconductor alloy contact has a perimeter defined by a convex curvature relative to a centerline of the via opening. The endpoints for the convex curvature that defines the metal semiconductor alloy contact are aligned to an interface between a sidewall of the via opening, a sidewall of the interconnect and an upper surface of the semiconductor substrate.
US08927375B2 Forming silicon-carbon embedded source/drain junctions with high substitutional carbon level
Embodiment of the present invention provides a method of forming a semiconductor device. The method includes providing a semiconductor substrate; epitaxially growing a silicon-carbon layer on top of the semiconductor substrate; amorphizing the silicon-carbon layer; covering the amorphized silicon-carbon layer with a stress liner; and subjecting the amorphized silicon-carbon layer to a solid phase epitaxy (SPE) process to form a highly substitutional silicon-carbon film. In one embodiment, the highly substitutional silicon-carbon film is formed to be embedded stressors in the source/drain regions of an nFET transistor, and provides tensile stress to a channel region of the nFET transistor for performance enhancement.
US08927374B2 Semiconductor device and fabrication method thereof
A method for fabricating a semiconductor device is disclosed. A strained material is formed in a cavity of a substrate and adjacent to an isolation structure in the substrate. The strained material has a corner above the surface of the substrate. The disclosed method provides an improved method for forming the strained material adjacent to the isolation structure with an increased portion in the cavity of the substrate to enhance carrier mobility and upgrade the device performance. The improved formation method is achieved by providing a treatment to redistribute at least a portion of the corner in the cavity.
US08927373B2 Methods of fabricating non-planar transistors including current enhancing structures
Methods of fabricating non-planar transistors including current enhancing structures are provided. The methods may include forming first and second fin structures directly adjacent each other overlying a substrate including an isolation layer. The methods may further include forming a spacer on the isolation layer including first and second recesses exposing upper surfaces of the first and second fin structures respectively. The spacer may cover an upper surface of the isolation layer between the first and second recesses. The methods may also include forming first and second current enhancing structures contacting the first and second fin structures, respectively, in the first and second recesses.
US08927372B2 Semiconductor device and method of fabricating the same
A semiconductor device may include a first insulating layer disposed on a substrate, a gate electrode disposed on the first insulating layer, and a second insulating layer disposed on the gate electrode and the first insulating layer. The second insulating layer includes a first discharge site.
US08927371B2 High-mobility multiple-gate transistor with improved on-to-off current ratio
A multi-gate transistor includes a semiconductor fin over a substrate. The semiconductor fin includes a central fin formed of a first semiconductor material; and a semiconductor layer having a first portion and a second portion on opposite sidewalls of the central fin. The semiconductor layer includes a second semiconductor material different from the first semiconductor material. The multi-gate transistor further includes a gate electrode wrapping around sidewalls of the semiconductor fin; and a source region and a drain region on opposite ends of the semiconductor fin. Each of the central fin and the semiconductor layer extends from the source region to the drain region.
US08927370B2 Method for fabricating memory
A method for fabrication a memory having a memory area and a periphery area is provided. The method includes forming a gate insulating layer over a substrate in the periphery area. Thereafter, a first conductive layer is formed in the memory area, followed by forming a buried diffusion region in the substrate adjacent to the sides of the first conductive layer. An inter-gate dielectric layer is then formed over the first conductive layer followed by forming a second conductive layer over the inter-gate dielectric layer. A transistor gate is subsequently formed over the gate insulating layer in the periphery area.
US08927367B2 Semiconductor device including metal-oxide-semiconductor field effect transistors and methods of fabricating the same
A method of fabricating a semiconductor device may include patterning a substrate to form trenches, forming a sacrificial layer to cover inner surfaces of the trenches, the sacrificial layer having a single-layered structure, forming sacrificial patterns by isotropically etching the sacrificial layer such that the sacrificial layer remains on bottom surfaces of the trenches, forming lightly doped regions in sidewalls of the trenches using the sacrificial patterns as an ion mask, removing the sacrificial patterns, and sequentially forming a gate insulating layer and a gate electrode layer in the trenches.
US08927365B2 Method of eDRAM DT strap formation in FinFET device structure
The specification and drawings present a new method, device and computer/software related product (e.g., a computer readable memory) are presented for realizing eDRAM strap formation in Fin FET device structures. Semiconductor on insulator (SOI) substrate comprising at least an insulator layer between a first semiconductor layer and a second semiconductor layer is provided. The (metal) strap formation is accomplished by depositing conductive layer on fins portion of the second semiconductor layer (Si) and a semiconductor material (polysilicon) in each DT capacitor extending to the second semiconductor layer. The metal strap is sealed by a nitride spacer to prevent the shorts between PWL and DT capacitors.
US08927350B2 Integration flow for LDD and spacer fabrication on a sacrificial amorphous carbon gate structure
An integration flow for LDD and spacer fabrication on a sacrificial amorphous carbon gate structure, form first spacer by way of depositing on the si substrate which have gate structure first. Gate is provided above the N-well and P-well on substrate. Spin coating a layer of photoresist in the first spacer, patterning the photoresist, and the gate structure above the N-well or P-well is exposed, ion lightly dope treatment is then used to the whole device. Remove the redundant photoresist and the first spacer layer, form the second spacer layer by depositing on the surface of the si substrate and gate, and spin coating another photoresist layer on the second spacer layer. Pattern the another photoresist layer, and another side of the gate structure is exposed, ion lightly dope treatment is then used to the whole device. Remove the redundant photoresist and the second spacer layer, form the third spacer layer and SiN layer by depositing on the gate and the Si substrate in turn. Form spacer by removing the redundant the third spacer layer and SiN layer.
US08927349B2 Semiconductor device and manufacturing method thereof
A semiconductor device includes an oxide semiconductor layer including a crystalline region over an insulating surface, a source electrode layer and a drain electrode layer in contact with the oxide semiconductor layer, a gate insulating layer covering the oxide semiconductor layer, the source electrode layer, and the drain electrode layer, and a gate electrode layer over the gate insulating layer in a region overlapping with the crystalline region. The crystalline region includes a crystal whose c-axis is aligned in a direction substantially perpendicular to a surface of the oxide semiconductor layer.
US08927348B2 Method of manufacturing group-III nitride semiconductor light-emitting device, and group-III nitride semiconductor light-emitting device, and lamp
Provided are a method of manufacturing a group-III nitride semiconductor light-emitting device in which a light-emitting device excellent in the internal quantum efficiency and the light extraction efficiency can be obtained, a group-III nitride semiconductor light-emitting device and a lamp. Included are an epitaxial step of forming a semiconductor layer (30) so as to a main surface (20) of a substrate (2), a masking step of forming a protective film on the semiconductor layer (30), a semiconductor layer removal step of removing the protective film and the semiconductor layer (30) by laser irradiation to expose the substrate (2), a grinding step of reducing the thickness of the substrate (2), a polishing step of polishing the substrate (2), a laser processing step of providing processing marks to the inside of the substrate (2), a division step of creating a plurality of light-emitting devices (1) while forming a division surface of the substrate (2) to have a rough surface.
US08927343B2 Package process
A package structure and a package process are provided. The package structure comprises a carrier having a carrying portion and a plurality of supporting bar remnants disposed around and extending outward from the carrying portion, a chip mounted to the carrying portion, and an encapsulant disposed on the carrier and covering the chip, wherein the supporting bar remnants are encapsulated by the encapsulant, and each of the supporting bar remnants has a distal end shrank from an outer surface of the encapsulant. A package process for fabricating the package structure is also provided.
US08927342B2 Leadframe for electronic components
The present invention specifies a leadframe for electronic components and a corresponding manufacturing process, in which the bonding islands are formed by welding individual, prefabricated segments of a bonding-capable material onto a stamped leadframe.
US08927339B2 Method of making thermally enhanced semiconductor assembly with bump/base/flange heat spreader and build-up circuitry
A method of making a semiconductor assembly that includes a semiconductor device, a heat spreader, an adhesive and a build-up circuitry is disclosed. The heat spreader includes a bump, a base and a flange. The bump defines a cavity. The semiconductor device is mounted on the bump at the cavity, electrically connected to the build-up circuitry and thermally connected to the bump. The bump extends from the base into an opening in the adhesive, the base extends vertically from the bump opposite the cavity and the flange extends laterally from the bump at the cavity entrance. The build-up circuitry includes a dielectric layer and conductive traces on the semiconductor device and the flange. The conductive traces provide signal routing for the semiconductor device.
US08927334B2 Overcoming chip warping to enhance wetting of solder bumps and flip chip attaches in a flip chip package
Structures and methods for forming good electrical connections between an integrated circuit (IC) chip and a chip carrier of a flip chip package include forming one of: a tensile layer on a front side of the IC chip, which faces a tops surface of the chip carrier, and a compressive layer on the backside of the IC chip. Addition of one of: a tensile layer to the front side of the IC chip and a compressive layer the backside of the IC chip, may reduce or modulate warpage of the IC chip and enhance wetting of opposing solder surfaces of solder bumps on the IC chip and solder formed on flip chip (FC) attaches of a chip carrier during making of the flip chip package.
US08927330B2 Methods for manufacturing a metal-oxide thin film transistor
Disclosed herein is a method for manufacturing a metal-oxide thin film transistor. The method includes the steps of: (a1) forming a gate electrode on a substrate; (a2) forming a gate insulating layer over the gate electrode; (a3) forming a metal-oxide semiconductor layer having a channel region on the gate insulating layer; (a4) forming a source electrode and a drain electrode on the metal-oxide semiconductor layer, wherein the source electrode is spaced apart from the drain electrode by a gap exposing the channel region; (a5) forming a mobility-enhancing layer on the channel region, wherein the mobility-enhancing layer is not in contact with the source electrode and the drain electrode; and (a6) annealing the metal-oxide semiconductor layer and the mobility-enhancing layer in an environment at a temperature of about 200° C. to 350° C.
US08927329B2 Method for manufacturing oxide semiconductor device with improved electronic properties
The amount of water and hydrogen contained in an oxide semiconductor film is reduced, and oxygen is supplied sufficiently from a base film to the oxide semiconductor film in order to reduce oxygen deficiencies. A stacked base film is formed, a first heat treatment is performed, an oxide semiconductor film is formed over and in contact with the stacked base film, and a second heat treatment is performed. In the stacked base film, a first base film and a second base film are stacked in this order. The first base film is an insulating oxide film from which oxygen is released by heating. The second base film is an insulating metal oxide film. An oxygen diffusion coefficient of the second base film is smaller than that of the first base film.
US08927328B2 3 dimensional semiconductor device and method of manufacturing the same
A 3D semiconductor device and a method of manufacturing the same are provided. The method includes forming a first semiconductor layer including a common source node on a semiconductor substrate, forming a transistor region on the first semiconductor layer, wherein the transistor region includes a horizontal channel region substantially parallel to a surface of the semiconductor substrate, and source and drain regions branched from the horizontal channel region to a direction substantially perpendicular to the surface of the semiconductor substrate, processing the first semiconductor layer to locate the common source node corresponding to the source region, forming a gate in a space between the source region and the drain region, forming heating electrodes on the source region and the drain region, and forming resistance variable material layers on the exposed heating electrodes.
US08927323B2 Interdigitated back contact heterojunction photovoltaic device
A photovoltaic device includes a crystalline substrate having a first dopant conductivity, an interdigitated back contact and a front surface field structure. The front surface field structure includes a crystalline layer formed on the substrate and a noncrystalline layer formed on the crystalline layer. The crystalline layer and the noncrystalline layer are doped with dopants having a same dopant conductivity as the substrate. Methods are also disclosed.
US08927321B2 Method for producing solid-state imaging device
The solid-state imaging device in which pixel electrodes, a photoelectric conversion portion having an organic film generating electric charge in response to incident light, a transparent counter electrode, and a sealing layer are formed on a substrate is produced by the method including causing a metal mask to come into close contact with a substrate surface, on which the pixel electrodes are disposed, by magnetic force; forming the organic film by vapor-depositing an organic substance to the substrate surface on which the pixel electrodes are disposed; removing the metal mask after the organic film is formed; forming the counter electrode on the organic film; and forming the sealing layer covering the counter electrode, wherein the metal mask has undergone half etching to have a half etching portion and comes into close contact with the substrate surface such that a lower surface of the half etching portion faces the pixel electrodes.
US08927309B2 Method for producing organic light-emitting diode illuminating device
A method for producing an OLED illuminating device includes steps of: (a) forming metal lines and power transmission lines on a substrate; (b) forming a patterned insulating layer to cover the metal lines and the power transmission lines; (c) forming a patterned first electrode layer on the insulating layer; (d) forming an organic light-emitting membrane structure on the first electrode layer; (e) forming a second electrode layer on the organic light-emitting membrane structure so that a plurality of luminescent pixels are formed; and (f) when one of the luminescent pixels is defective, cutting one of the power transmission lines that is connected to the defective one of the luminescent pixels using an energy beam.
US08927308B2 Method of forming bus line designs for large-area OLED lighting
Systems, and methods for the design and fabrication of OLEDs, including large-area OLEDs with metal bus lines, are provided. For a given panel area dimension, target luminous emittance, OLED device structure and efficiency (as given by the JVL characteristics of an equivalent small area pixel), and electrical resistivity and thickness of the bus line material and electrode onto which the bus lines are disposed, a bus line pattern may be designed such that Fill Factor (FF), Luminance Uniformity (U) and Power Loss (PL) may be optimized. One general design objective may be to maximize FF, maximize U and minimize PL. Another approach may be, for example, to define minimum criteria for U and a maximum criteria for PL, and then to optimize the bus line layout to maximize FF. OLED panels including bus lines with different resistances (R1) along a length of the bus line are also described.
US08927307B2 Light emitting device and electronic device
To improve light extraction efficiency of light emitting elements such as electroluminescent elements. A first electrode 101, a light emitting layer 102, and a second electrode 103 are formed over a substrate 100, which partially constitute a light emitting element. Light produced in the light emitting layer 102 is emitted out through the second electrode 103. A plurality of three-dimensional bodies 104 are provided in contact with a surface of the second electrode 103. With the provision of the bodies 104, light totally reflected between the second electrode 103 and the air enters the bodies 104 and can be emitted through faces of the bodies 104 that are not parallel to the interface between the bodies and the second electrode 103.
US08927306B2 Etched-facet lasers having windows with single-layer optical coatings
An edge-emitting etched-facet optical semiconductor structure has a substrate, an active multiple quantum well (MQW) region formed on the substrate, and a ridge waveguide formed over the MQW region extending in substantially a longitudinal direction between a waveguide first etched end facet and a waveguide second etched end facet. A mask layer used to form windows in which the etched end facets are disposed consists of a single dielectric material disposed directly on the ridge waveguide. An optical coating consisting of no more than one layer of the same dielectric material of which the second mask is made is disposed directly on the second mask and disposed directly on the windows to coat the etched end facets.
US08927299B2 Sample carrier for effecting chemical assays
There is disclosed apparatus and a system for effecting testing on a sample, such as for medical testing. The apparatus includes a sample chip (30) provided with at least two chambers (48, 50) within which analyte and a sample to be tested can be located, one chamber being a mixing chamber (48) and the other a detection chamber (50), the latter being provided with a sensor or means to enable sensing of one or more parameters pertaining to the sample. A detector unit (70, 170) includes a slot (76) for holding a sample carrier (30), drive means (94) for moving parts of a sample from the mixing chamber (48) to the detection chamber (50), such as by electromagnetic force, sensing means (60) for sensing the one or more parameters, a diagnostic unit (84) for analyzing the sensed parameters and a display unit (72) for displaying the results of the test to a user. The test unit (70, 170) is preferably handheld, which the sample carrier (30) is preferably in the form of a disposable chip.
US08927297B2 Methods to measure dissociation rates for ligands that form reversible covalent bonds
The crystal structure of the ligand binding domain of ERR-α in complex with a ligand that forms a reversible thioether bond to Cys325 of ERR-α, methods to measure dissociation rates for ligands that form reversible covalent bonds, and methods to design ligands that form reversible covalent bonds for use as modulators of ERR-α activity are disclosed. The crystal structure and methods provide a novel molecular mechanism for modulation of the activity of ERR-α and provide the basis for rational drug design to obtain potent specific ligands for use as modulators of the activity of this new drug target.
US08927296B2 Method of reducing liquid volume surrounding beads
The invention provides droplet actuators and droplet actuator techniques. Among other things, the droplet actuators and methods are useful for manipulating beads on a droplet actuator, such as conducting droplet operations using bead-containing droplets on a droplet actuator. For example, beads may be manipulated on a droplet actuator in the context of executing a sample preparation protocol and/or an assay protocol. An output of the methods of the invention may be beads prepared for execution of an assay protocol. Another output of the methods of the invention may be results of an assay protocol executed using beads. Among the methods described herein are methods of concentrating beads in droplets, methods of washing beads, methods of suspending beads, methods of separating beads, methods of localizing beads within a droplet, methods of forming emulsions in which droplets include beads, methods of loading beads into a droplet operations gap of a droplet actuator, methods of organizing beads in a monolayer, and methods of capturing, trapping or restraining beads.
US08927295B2 Method and apparatus for conversion of multiple analyte cation types to a single analyte anion type via ion/ion charge inversion
An apparatus and method for a sample using a mass spectrometer is described, including, generating ions of a first polarity from an analyte using electrospray ionization; generating ions of a second polarity from a reagent; injecting the ions of the first polarity and ions of the second polarity in sequence into a chamber of the mass spectrometer such that the ions of the first polarity and the ions of the second polarity interact in the chamber to form analyte ions having the second polarity; and, analyzing the mass spectrum of the analyte ions of the second polarity. A reagent such as a polyamidomine is selected to preferentially yield analyte ions of the second polarity having a desired mass-to-charge ratio.
US08927285B2 Micro-alga belonging to genus Navicula, process for production of oil by culture of the micro-alga, and oil collected from the micro-alga
Disclosed are: a microalga highly capable of producing aliphatic hydrocarbons of 16 to 26 carbon atoms; a process for producing oil, which comprises a step of culturing the microalga; oil collected from the microalga; a fuel produced from the microalga; and a method for fixing carbon dioxide, which comprises a step of culturing the microalga.Specifically disclosed is a microalga belonging to the genus Navicula, which is capable of producing aliphatic hydrocarbons of 16 to 26 carbon atoms. More specifically disclosed is a microalga, Navicula oiliticus strain JPCC DA0580 (FERM BP-11201).
US08927281B2 Method for expanding hematopoietic stem cells
The present invention relates to compounds and compositions for expanding the number of CD34+ cells for transplantation. The invention further relates to a cell population comprising expanded hematopoietic stem cells (HSCs) and its use in autologous or allogeneic transplantation for the treatment of patients with inherited immunodeficient and autoimmune diseases and diverse hematopoietic disorders to reconstitute the hematopoietic cell lineages and immune system defense.
US08927280B2 Compositions and methods for promoting the generation of definitive endoderm
Certain embodiments disclosed herein are directed to a method of producing endoderm cells, such as definitive endoderm cells by exposing stem cells such as embryonic stem cells or induced pluripotent stem (iPS) cells to an effective amount of at least one compound described herein to differentiate the stem cells into the endoderm cells such as definitive endoderm cells. Differentiated endoderm cells produced by the methods disclosed herein can be differentiated into pancreatic epithelium, and other endoderm derivatives such as thymus, liver, stomach, intestine and lung. Another aspect of the present invention relates to a method of producing pancreatic progenitor cells, such as Pdx1-positive pancreatic progenitor cells by exposing endoderm cells, such as definitive endoderm cells to an effective amount of at least one compound described herein to differentiate the definitive endoderm cells into Pdx1-positive pancreatic progenitor cells. Kits and compositions comprising Pdx1-positive pancreatic progenitor produced using the methods are also described.
US08927279B2 Methods for reprogramming somatic cells
The invention provides methods for reprogramming somatic cells to generate multipotent or pluripotent cells. Such methods are useful for a variety of purposes, including treating or preventing a medical condition in an individual. The invention further provides methods for identifying an agent that reprograms somatic cells to a less differentiated state.
US08927277B2 Method of efficiently establishing induced pluripotent stem cells
Provided are a method of improving the efficiency of establishment of iPS cells, comprising the step of contacting one or more substances selected from the group consisting of members of the GLIS family (e.g., GLIS1) and nucleic acids that encode the same and one or more substances selected from the group consisting of members of the Klf family and nucleic acids that encode the same, with a somatic cell, an iPS cell comprising an exogenous nucleic acid that encodes a member of the GLIS family or a member of the Klf family, that can be obtained by the method, and a method of producing a somatic cell by inducing the differentiation of the iPS cell.
US08927276B2 Ex vivo progenitor and stem cell expansion and differentiation for use in the treatment of disease of the nervous system
The present invention relates to a simplified process, which is shorter in time, for propagation of proliferating cells, such as e.g. progenitor or stem cells, by means of a biphasic culturing system having a differentiation supporting component and a proliferation supporting component, and to the use of the stem cell cultures obtained in this way for cell therapy purposes. The present invention invention describes a method, which is highly efficient to prime stem or progenitor cells to differentiation using non-attachment matrices and differentiation supporting component. The cells produced therefrom may be used to treat a variety of neurodegenerative disorders.
US08927272B2 Method and device for performing biopsies on a vesicular object
A method for removing material from a vesicular object by securing the object, penetrating the object with a pipette, such pipette having a sealed distal tip and an aperture, advancing said pipette into the object in such a manner as to place the aperture directly adjacent to the material to be removed from the object, applying vacuum inside the pipette thereby drawing the material to be removed from the object into the pipette, and removing the pipette from the object in such a manner as to cut or otherwise separate the material in the pipette from the object thereby leaving the material removed from the object in the pipette while leaving the object undamaged.
US08927271B1 Compositions and methods for detecting target analytes
This invention is directed to compositions and methods for determining target analytes. The compositions disclosed relate to cell-linker-probe complexes. The disclosed methods (including multiplex methods) utilize said cell-linker-probe complexes for target analyte determination.
US08927266B2 Garbage separating apparatus and food waste disposal system including the same
There is provided a garbage separating apparatus including an input unit having an inlet opening through which garbage is input, a crushing unit configured to crush garbage input through the inlet opening, a filtering chamber having an outlet opening and a perforation member provided with a plurality of holes for allowing separation of the garbage crushed by the crushing unit, a food waste collection chamber for accommodating, among the crushed garbage, food waste having passed through the perforation member, and a sweeper device configured to move, among the crushed garbage, impurity garbage remaining on the perforation member to the outlet opening.
US08927264B2 Electro medical tool optimization system
Methods and apparatus are disclosed herein to improve on and expand the range of electrical and electromagnetic frequencies used in therapeutic electro medical devices. The present invention uses electrical and electromagnetic frequency generators and detectors integrated with a live cell imaging system that provides feedback to the frequency generators using data derived from said imaging system.
US08927260B2 Anaylte detection system using an oscillating magnetic field
An analyte detection system includes a detector situated close to a well of a substrate. The well includes conjugated paramagnetic beads. The detection system also includes a magnetic field generator that provides an oscillating magnetic field in the well and the detector, an oscillator circuit coupled to the detector, and a circuit coupled to the detector that detect the conjugated paramagnetic beads. A method includes applying a magnetic field to well of a substrate with conjugated paramagnetic beads, alternating the polarity of the magnetic field, detecting a waveform associated with the alternating magnetic field, and associating the waveform with the quantity of conjugated paramagnetic beads. An analyte detection kit includes a substrate with an attached antibody that is reactive to the analyte, a conjugated paramagnetic particle, and a conjugated paramagnetic particle detector.
US08927259B2 Piezoelectric microcantilever sensors for biosensing
A piezoelectric microcantilever for sensing compounds or molecules. The piezoelectric microcantilever, may include at least one electrode, an insulation layer, a receptor, an immobilization layer, a non-piezoelectric layer and a piezoelectric layer. The sensor is capable of self actuation and detection. The piezoelectric layer may be constructed from a highly piezoelectric thin lead magnesium niobate-lead titanate film, a highly piezoelectric thin zirconate titanate film, a highly piezoelectric lead-free film. Methods of using the sensors and flow cells and arrays including the sensors are also described.
US08927251B2 Targeting of herpes simplex virus to specific receptors
The invention relates to engineered Herpes simplex virus (HSV) particles that are targeted to one or more specific binding pair members, such as receptors. Also, recombinant vectors for producing such HSV particles are provided. By reducing the affinity of HSV for its natural receptor(s) and increasing the affinity for a selected receptor, the HSV particles of the invention are useful for targeting cells that express the selected receptor, which itself may be a product of genetic engineering. The ability to selectively target cells render the HSV particles. particularly useful in selectively diagnosing, treating, and imaging cells bearing the selected binding pair member, such as a receptor. The invention also provides for polynucleotide-based therapy to cells bearing the selected binding pair member such as a receptor.
US08927246B2 Method to increase the production of extracellular polymeric substances (EPS) in a Acidithiobacillus ferrooxidans culture by the inhibition of enzymes of tricarboxilic acid cycle
A method of increasing the production of extracellular polymeric substances (EPS) in an Acidithiobacillus ferrooxidans culture is disclosed. The method includes inhibiting an enzyme, such as citrate synthase, aconitase, or isocitrate dehydrogenase, in the tricarboxylic acid (TCA) cycle leading to alpha-ketoglutarate.
US08927244B2 Organophosphorus hydrolase
The present disclosure provides methods, devices, systems and compositions for detecting and/or modifying chemical agents. In some embodiments, a biosensor may be configured to detect a chemical agent, modify that agent to a form with reduced toxicity, and/or detect the modified form of the chemical agent. The present disclosure also relates, in some embodiments, to variant organophosphorus hydrolase having one or more desirable amino acid substitutions.
US08927242B2 Treatment and prophylaxis for obsessive compulsive disorder
An embodiment is a method of preventing, mitigating or treating Pediatric Autoimmune Neuropsychiatric Disorders Associated with Streptococcal Infections (PANDAS) that includes administering an effective amount of a medicament comprised of Streptococcus oralis 89a to a human to prevent, mitigate or treat PANDAS.
US08927241B2 Microbial engineering for the production of chemical and pharmaceutical products from the isoprenoid pathway
The invention relates to the production of one or more terpenoids through microbial engineering, and relates to the manufacture of products comprising terpenoids.
US08927240B1 Thermal fractionation of biomass of non-lignocellulosic origin for multiple high-quality biofuels
Methods for production of multiple biofuels through thermal fractionation of biomass feedstocks are described.
US08927239B2 Process for improving the yield and efficiency of an ethanol fermentation plant
A process for improving the yield and efficiency of an ethanol fermentation plant that receives organic fermentable feedstock material, prepares the feedstock for fermentation, ferments the feedstock with yeast to produce ethanol, and produces stillage as a byproduct of ethanol fermentation. The process steps which can be operated independently or in combination, may include, but are not limited to, degrading fatty acids in the fermentable feedstock material prior to fermentation; degrading cellulose and hemicellulose present in the feedstock prior to fermentation; adding a surfactant to the fermentable feedstock; separating a liquid fraction from the stillage; recycling the liquid fraction to be combined with the fermentable feedstock; recovering a solid fraction from the stillage; and introducing at least a portion of the solid fraction to an anaerobic digester to produce methane.
US08927228B2 Reagent for blood cell counting and blood analysis method
Disclosed is a novel reagent for blood cell counting and a novel blood analysis method, which enable blood cells such as leukocytes to be counted with high accuracy by dissociating platelet aggregates in capillary blood collected from a living body. The reagent for blood cell counting is used to dilute capillary blood collected from a living body to prepare a blood sample in order to count blood cells in the collected capillary blood using a particle analyzer, and is an aqueous solution containing a chloroquine salt.
US08927225B2 Human catechol-O-methyltransferase (COMT) assay
Disclosed is an assay (method) to quantify the amounts of catecholamine-O-methyltransferase (COMT) protein in samples, such as extracts from cell cultures, body fluids, tissues, and environmental samples. It uses novel agents (anti-NE, COMT-NE, or COMT-epitope-NE) in combination with two previously described agents (anti-COMT and COMT) in a competitive ELISA system to achieve this aim.
US08927221B2 Diagnostic marker for kidney diseases and use thereof
The present invention relates to novel diagnostic markers for kidney disease and the use thereof.
US08927219B2 Method for evaluation of quality of blood sample
A method for evaluating the quality of a blood sample, comprising the steps of: mixing labeled anti-cortisol antibodies with a blood sample to be subjected, to conduct the antigen-antibody reaction of the labeled anti-cortisol antibody with cortisol contained in the blood sample, developing a mixture obtained in the above step on an immunochromatographic test strip having a substrate on which cortisol is immobilized to cause the antigen-antibody reaction of the labeled anti-cortisol antibodies which are free in the mixture with the cortisol immobilized on the substrate, thereby bonding the antibody to the cortisol, determining the amount of the labeled anti-cortisol antibodies bonded to the cortisol in the above step, and evaluating whether or not the blood sample has a quality suitable for suprarenal vein sampling test on the basis of the amount of the labeled anti-cortisol antibodies determined in the above step.
US08927215B2 GNA11 mutations in melanoma
The present invention provides methods of detecting mutations in a GNA11 gene in a melanocytic neoplasm for diagnostic and prognostic purposes. The invention further provides methods of treating such melanocytic neoplasm by modulating the activity of the mutated GNA11 gene.
US08927210B2 Conjugate complexes for analyte detection
The present invention relates to novel conjugate complexes for immunoassays as well as kits comprising these conjugate complexes, methods of producing these complexes, and methods of detecting an analyte by use of these complexes. The conjugate complexes of the invention comprise one or more non-nucleic acid receptors capable of specifically binding an analyte, one or more nucleic acid markers comprising a predetermined nucleotide sequence, one or more first linker molecules capable of specifically binding the non-nucleic acid receptor and the nucleic acid marker, and one or more second linker molecules capable of specifically binding the first linker molecules.
US08927203B2 Platelet preservation package comprising a short to ultra-short acting antiplatelet agent and anticoagulant
The present invention relates to compositions and methods for storing platelets to preserve the function and freshness of the platelets. More particularly, the present invention relates to the use of a preservative composition having an antiplatelet agent, an anticoagulant, and an oxygen carrier, for maintaining the freshness of platelets. Additionally, the composition may also contain an ultra-short acting broad spectrum anti-microbial agents. The preservative composition may be used to store platelets in a liquid state, a frozen state, or a freeze-dried state.
US08927202B2 Compositions for enhancing the viability of animal cells, tissues, and organ explants comprising two low molecular weight PEGs
Disclosed are compositions and methods for the preservation, storage, and transport of living biological tissues, organs, and populations of isolated cells. In particular, the disclosed compositions and processes permit mammalian cells, tissues, and organs to be harvested from suitable donor animals, stored for prolonged periods, and transported to the site of recipient implantation, all without significant loss of cell viability, biological activity, and/or tissue integrity.
US08927186B2 Toner, and developer, image forming method and process cartridge using the toner
A toner for use in developing an electrostatic latent image is provided. The toner includes a colored particulate material including at least a binder resin and a colorant; and an external additive present on a surface of the colored particulate material and including a particulate crystalline hydroxyapatite. The particulate crystalline hydroxyapatite has an average aspect ratio of not less than 3 and less than 30.
US08927182B2 Photosensitive resist composition for color filters for use in electronic paper display devices
The present invention relates to a photosensitive resist composition comprising a colorant. More specifically, it relates to a photosensitive resist composition which is advantageously used for the production of a color filter for use in electronic paper displays devices, color image pick-up elements and the like.
US08927181B2 Reflective mask blank for EUV lithography
To provide a reflective mask blank for EUV lithography having an absorber layer having optical constants suitable for reducing the thickness. A mask blank for EUV lithography comprising a substrate, and a reflective layer for reflecting EUV light and an absorber layer for absorbing EUV light formed in this order on the substrate, wherein the absorber layer contains tantalum (Ta) and palladium (Pd), and in the absorber layer, the content of tantalum (Ta) is from 10 to 80 at %, the content of palladium (Pd) is from 20 to 90 at %, and the total content of Ta and Pd is from 95 to 100 at %.
US08927177B2 Methods for preparing carbon black sheet with metallic nanoparticle thin layer by electrophoresis deposition and membrane electrode assembly (MEA) for proton exchange membrane fuel cell
A carbon black sheet with a thin layer of metal nanoparticles is provided by pulse electroplating, which allows metal nanoparticles such as platinum to be uniformly dispersed on a carbon black layer and is very thin, enhancing the efficiency of a metal catalyst such as platinum. The process is also used to form a polymer membrane electrode assembly (MEA) for a fuel cell.
US08927172B2 Flat-tubular solid oxide cell stack
Disclosed herein is a flat-tubular solid oxide cell stack. The cell stack includes a plurality of unit cells which are stacked one on top of another. Each unit cell includes a flat-tubular electrode support made of a porous conductive material. A first-gas flow channel is formed in the electrode support in a longitudinal direction thereof. First gas flows along the first-gas flow channel. A second-gas flow channel is formed on the outer surface of the electrode support. Second-gas flows along the second-gas flow channel. A connection hole is formed on each of opposite ends of the first-gas flow channel of each of the unit cells and communicates with the first-gas flow channel of the adjacent unit cell so that the first gas flows along the unit cells in a zigzag manner in the longitudinal directions of the unit cells.
US08927170B2 Flow field plate for reduced pressure drop in coolant
The pressure drop associated with the coolant flow in the coolant transition regions of a typical high power density, solid polymer electrolyte fuel cell stack can be significant. This pressure drop can be reduced by enlarging the height of the coolant ducts in this region of the associated flow field plate so that the ducts extend beyond the plane of the plate. The height change can be accommodated by offsetting the ducts in adjacent cells in the stack and by employing non planar MEAs in this region. By reducing the pressure drop, improved coolant flow sharing is obtained.
US08927169B2 Fuel cell system and mobile body
An object of the present invention is to provide a fuel cell system and a mobile body capable of restraining freeze in an air cleaner. The fuel cell system includes an air cleaner for cleaning the air to be supplied to a fuel cell and a heater for heating the air cleaner. The air cleaner can be alternatively heated by supplying a refrigerant in a refrigerant piping system to the air cleaner instead of using the heater.
US08927165B2 Stack cathode inlet RH (relative humidity) control without RH sensing device feedback
A method for controlling relative humidity (RH) of a cathode side of a fuel cell stack in a fuel cell system that includes an RH sensor on a cathode inlet line for providing an RH signal indicative of the RH of cathode inlet air. If the RH sensor is providing a valid RH signal, the RH signal is calculated as an RH average of the cathode inlet air. When the RH sensor is not providing a valid RH signal, the calculated RH average is utilized to control the cathode inlet air RH. If the RH sensor is not providing a valid signal during start-up, then the stack power is temporarily set at an optimum level for a known cathode inlet air RH.
US08927164B2 Fuel cell system with scavenging means and control unit thereof
Even in a fuel cell system which performs scavenging processing after the power generation of a fuel cell is stopped, the operation time for when a battery is being operated can be increased. When determining that the condition of running out of gas occurs based on a sensor value of a pressure sensor, a control unit stops the power generation of the fuel cell. The control unit, for example, shortens the time required for scavenging processing and then performs the scavenging processing. On the other hand, when determining that the condition of running out of gas does not occur and when the power generation of the fuel cell should be stopped, the control unit stops the power generation and then performs normal scavenging processing.
US08927163B2 Apparatus for portable fuel cells and operating method thereof
Disclosed are an apparatus for portable fuel cell and an operation method thereof, wherein stabilization state after initial operation can be determined using OCV.
US08927161B2 Fuel cell system
A fuel cell system including an ejector that merges a hydrogen gas to be supplied from a hydrogen tank to a fuel cell with a hydrogen-off gas exhausted from the fuel cell and supplies the resulting gases to the fuel cell. A hydrogen pump that pressurizes the hydrogen-off gas in a hydrogen circulation flow path and sends the hydrogen-off gas toward a hydrogen supply flow path and a control unit that controls, when the pressure of the hydrogen-off gas in the hydrogen circulation flow path is increased by the ejector and the hydrogen pump, the pressure of the hydrogen gas to be supplied to the ejector and the pressure increase of the hydrogen-off gas realized by the hydrogen pump so that the pressure increase of the hydrogen-off gas realized by the ejector is 0 or higher.
US08927158B2 Nonaqueous electrolyte secondary battery and nonaqueous electrolytic solution for nonaqueous electrolyte secondary battery
A nonaqueous electrolyte secondary battery includes a positive electrode having a positive-electrode active material, a negative electrode having a negative-electrode active material, and a nonaqueous electrolytic solution having a nonaqueous solvent dissolving a solute. The negative-electrode active material includes powdered silicon and/or a silicon alloy, the nonaqueous electrolytic solution includes additives composed of at least one fluorinated lithium phosphate selected from the group consisting of lithium monofluorophosphate, lithium difluorophosphate, and lithium trifluorophosphate and a diisocyanate compound, and the nonaqueous solvent includes a chain carbonate compound.
US08927155B2 Non-aqueous electrolyte secondary battery and producing method of electrode
A non-aqueous electrolyte secondary battery includes a positive electrode, a negative electrode, an electrolyte, and a porous protective film formed on either one or both surfaces of the positive and negative electrodes. The porous protective film includes a binder, fine particles, and a surfactant.
US08927154B2 Lithium titanium oxide, method of preparing lithium titanium oxide, and lithium rechargeable battery including lithium titanium oxide
A spherical primary particle of a lithium titanium oxide of which average diameter is in the range of about 1 to about 20 μm, a method of preparing the spherical primary particle of the lithium titanium oxide, and a lithium rechargeable battery including the spherical primary particle of the lithium titanium oxide.
US08927150B2 Binder and positive active material composition for rechargeable lithium battery, and rechargeable lithium battery including same
A rechargeable lithium battery includes a binder for a rechargeable lithium battery, and a positive active material composition. The binder for the rechargeable lithium battery includes a nitrile-based polymer nanoparticle and a fluorine-containing polymer nanoparticle.
US08927149B2 Negative electrode for lithium ion secondary battery and battery using same
There is provided a negative electrode for a lithium-ion secondary battery, including a conductive substrate, a negative electrode active material layer containing a negative electrode active material capable of absorbing and desorbing lithium ions and a conductive member having a lower elastic modulus than that of the conductive substrate, wherein at least part of the negative electrode active material is connected to the conductive substrate via the conductive member. There is also provided a lithium-ion secondary battery with such a negative electrode.
US08927148B2 Power storage device
A power storage device including a positive electrode in which a positive electrode active material is formed over a positive electrode current collector and a negative electrode which faces the positive electrode with an electrolyte interposed therebetween is provided. The positive electrode active material includes a first region which includes a compound containing lithium and one or more of manganese, cobalt, and nickel; and a second region which covers the first region and includes a compound containing lithium and iron. Since a superficial portion of the positive electrode active material includes the second region containing iron, an energy barrier when lithium is inserted into and extracted from the surface of the positive electrode active material can be decreased.
US08927141B2 Rechargeable battery
A rechargeable battery includes an electrode assembly having a positive electrode, a negative electrode, and a separator located between the positive electrode and the negative electrode; a case housing the electrode assembly, the case having an opening; a cap assembly including a cap plate coupled to the opening of the case and a vent member on the cap plate adapted to discharge a gas from the case; and a separation member located between the electrode assembly and the cap plate to prevent the electrode assembly from significantly moving toward the cap plate.
US08927136B2 Battery cover insulator system for fluid communication with battery vents
A battery module is provided that includes a plurality of battery cells. Each battery cell can include a vent. A cover encloses the vents, and an insulation member is located between the plurality of battery cells and the cover. The insulation member can include a bent part that sealably engages the cover. The plurality of battery cells can be arranged in a first direction such that the vent of each battery cell is aligned with the vent of an adjacent battery cell. The cover and the insulating member can extend in the first direction to enclose the vents.
US08927130B2 Electrolyte for redox flow battery and redox flow battery including the same
An electrolyte for a redox flow battery and a redox flow battery including the electrolyte, the electrolyte including a metal-ligand coordination compound as a cation and an anion containing at least four atoms linked to each other by a straight chain in a certain direction.
US08927129B2 Interconnection-less liquid fin design for battery cooling module
A battery module is described. The battery module includes a plurality of cooling fins having an inlet section, a center section, and an outlet section, the inlet and outlet sections extending from opposite ends of the center section at an angle from a plane defined by the center section, the cooling fins having at least one cooling channel extending from an inlet of the inlet section through the center section to an outlet of the outlet section; and a plurality of battery cells positioned in the center section between the plurality of cooling fins. A method of cooling a battery module is also described.
US08927126B2 Protection circuit assembly and battery pack having the same
A battery pack includes a bare cell and a protection circuit assembly electrically connected to the bare cell. The protection circuit assembly includes a protection circuit board on which a protection module, a PTC thermistor, an external connection terminal, a first connection terminal and a second connection terminal are mounted. A first lead plate and a second lead plate are in contact with the first connection terminal and the second connection terminal, respectively. The protection circuit board defines opposite lateral edges and a first groove in each of the opposite lateral edges, and the first lead plate is exposed through the first groove.
US08927119B2 Compound having substituted anthracene ring structure and pyridoindole ring structure, and organic electroluminescent device
There is provided an organic compound having excellent characteristics, including excellent electron-injecting/transporting performance, hole blocking ability, and high stability in the thin-film state, for use as material of an organic electroluminescent device having high efficiency and high durability. There is also provided a high-efficient and high-durable organic electroluminescent device using the compound. The compound is represented by general formula (1) having a substituted anthracene ring structure and a pyridoindole ring structure. The organic electroluminescent device includes a pair of electrodes, and one or more organic layers sandwiched between the pair of electrodes, and the compound is used as a constituent material of at least one organic layer.
US08927117B2 Materials for organic electroluminescence device
The present invention relates to a compound of the formula (1) and (2) The invention further relates to a process to produce the compound. The invention additionally relates and an electronic device containing the compound of the formula (1) or (2). The electronic device can be an organic electroluminescence devices, particularly a blue emitting device, in which compounds are used as host materials or dopants in the emitting layer and/or as hole transport materials and/or as electron transport materials.
US08927113B2 Composite metal ingot
A composite metal ingot, comprising at least two layers of differing alloy composition, wherein pairs of adjacent layers consisting of a first alloy and a second alloy are formed by applying the second alloy in a molten state to the surface of the first alloy while the surface of the first alloy is at a temperature between solidus and liquidus temperatures of the first alloy to form an interface there between, wherein the second alloy is a high or medium strength heat treatable aluminum alloy, and further wherein one or more alloy components from the second alloy are present within grain boundaries of the first alloy adjacent said interface.
US08927112B2 Protective coatings for controlled corrosion resistance
The present invention provides a galvanized metal reinforcing tensile member for use in mechanically stabilized earth structures and a method for delaying an onset of corrosion of the tensile member. The tensile member includes a structurally compromised region in a portion of the tensile member and a corrosion protective coating on at least the structurally compromised region, the coating of a thickness and composition to delay an onset of corrosion at the structurally compromised region to correspond to at least that of a remainder of the tensile member.
US08927107B2 Multi-coated metallic products and methods of making the same
The present invention relates generally to a coated jewelry article or a coated component of a jewelry article, comprising a jewelry article or a component of a jewelry article, a first metallic coating, and a second metallic coating.
US08927106B2 Multilayer polyurethane protective films
A multilayer protective film comprising a first layer, a second layer and a PSA layer. The first layer at least comprises a polyester-based polyurethane, a polycarbonate-based polyurethane or a combination or blend of both. The second layer at least comprises a polycaprolactone-based thermoplastic polyurethane. The PSA layer comprises a pressure sensitive adhesive. One major surface of the first layer is bonded to one major surface of the second layer, and the PSA layer is bonded to an opposite major surface of the second layer such that the second layer is sandwiched between the first layer and the PSA layer.
US08927105B2 Biomass article and method of manufacturing
A biodegradable biomass article for use in construction includes a cellulose biomass. The cellulose biomass includes an alkaline crystalline substance. An adhesive layer covers an outer surface of the biomass, and a sealing layer covers the adhesive layer. A method for manufacturing the biodegradable biomass article includes drying a cellulose biomass, and mixing the biomass with water into a slurry. The slurry is heated, and strained after the step of heating, resulting in a residual paste. The residual paste is compressed to form a biomass mat. The biomass mat is heated, and an adhesive layer is applied which covers the biomass mat. A sealing layer is applied over the adhesive layer.
US08927102B2 Metal suboxide and methods of preparing same
A metal suboxide having a specific surface area of greater than or equal to about 1.5 m2/g is prepared by preparing a metal suboxide precursor, and heat-treating the metal suboxide precursor.
US08927101B2 Abrasive particles having a unique morphology
An abrasive particle having an irregular surface, wherein the surface roughness of the particle is less than about 0.95. A method for producing abrasive particles having a unique surface morphology including providing a plurality of abrasive particles; providing a plurality of metal particles; mixing the abrasive particles and the metal particles to form a mixture; compressing the mixture to form a compressed mixture; heating the compressed mixture; and recovering modified abrasive particles.
US08927100B2 Activatable adhesive, labels, and related methods
An activatable adhesive that is formulated to readily absorb energy from a given radiation source, an activatable adhesive label that incorporates such an activatable adhesive, a system for activating such labels, and related methods and uses are described. The activatable adhesive includes a plasticizer, a tackifier, and an adhesive base polymer that includes butyl acrylate, styrene, methyl methacrylate, methacrylic acid, and acrylic acid.
US08927094B2 Printed article and method of manufacturing printed article
A printed article includes a base material, a first printed layer, a second printed layer, and a third printed layer. The first printed layer is printed with a first ink in a first area of the base material. The second printed layer is printed with a second ink in a second area different from the first area of the base material. The second ink is different in a property or function from the first ink and having a color difference with respect to the first ink. The third printed layer is printed with a third ink, and covers or fills a boundary between the first printed layer and the second printed layer, and has a color difference with respect to the first printed layer and the second printed layer.
US08927091B2 Display device and manufacturing method thereof
A display device and method thereof which minimizes introduction of oxygen and moisture from the outside includes an insulating substrate, a display part formed on the insulating substrate, a cover substrate combined with the insulating substrate, a filler provided between the insulating substrate and the cover substrate, the filler includes a first region and a second region spaced from the first region and formed at a circumference of the first region, and a moisture absorbent formed in a space between the first region and the second region.
US08927088B2 Helmet designs utilizing foam structures having graded properties
Disclosed herein is a composite structure for deflecting and spreading kinetic energy transmission after various types of impacts utilizing foam structures having graded properties. The structure has a first composite layer, composed of a discrete reinforcement and a continuous binder. The helmet receives contact of an object that transfers kinetic energy to a first composite layer. The helmet uses a second composite layer adjacent to the first composite layer designed such that the second composite layer compresses and expands into an expansion zone in the second composite layer. The second composite layer has expansion structures with a graded modulus such that the material at the tip of an expansion structure has a low modulus and the modulus in the expansion structure increases as it moves from the tip to the base of the expansion structure.
US08927086B2 Method of making a reinforcing mat for a pultruded part
A method of preparing a reinforcing structure for use in manufacture a pultruded part where the reinforcing structure is pulled through a pultrusion die in a continuous longitudinal pull direction. The method includes arranging a plurality of first reinforcing fibers in a transverse direction and attaching a permeable transport web of staple fibers to the first reinforcing fibers such that the portion of the first reinforcing fibers oriented in the direction transverse comprises at least 30% of a volume of materials comprising the reinforcing structure.
US08927085B2 Cross laminated strand product
A cross laminated strand product formed from a laminate of a plurality of layers, wherein each layer includes substantially aligned strands of wood bonded together with a binder including an isocyanate resin, and wherein the respective strands of adjacent layers are oriented substantially perpendicularly to one another.
US08927083B2 Handle and method of fabricating a handle for a medical device
A handle and a method of fabricating a handle, or another article of manufacture, that minimizes or avoids the likelihood of accumulating contamination before, during, or after use. The article includes a core element, for example, a plastic core element, having an outer surface and raised indicia, such as, letters or logos, extending beyond the outer surface; and a light-transferring material completely covering the raised indicia of the core element wherein the raised indicia are visible through the light-transferring material. The complete covering of the indicia avoids separation between the cover and the indicia. The cover material may be a translucent thermoplastic elastomer. Though particularly applicable to the medical device industry, aspects of the invention may be applied to a broad range of industries.
US08927081B2 Flexible seam joint for use in robotic skin
An artificial skin such as an outer covering or skin for an animatronic character. The skin may be formed by a method that includes providing a mold assembly with an exterior mold and a core. In the mold assembly, a cavity is formed between inner surfaces of the exterior mold and exterior surfaces of the core that defines the skin system. The mold assembly includes a seam-forming wall extending between the inner and exterior surfaces. The method includes inserting an elongate, tubular guide through holes in the seam-forming wall and pouring an elastomeric material into the mold to occupy the cavity between the exterior mold and the interior core. The method includes, after the material has hardened, cutting a seam in the skin system by cutting the material along the seam-forming wall. The tubular guide is separated into guide segments and a staggered joint is formed at the cut seam.
US08927080B1 Repositionable self stick paint swatch for testing samples of paint on a wall
A swatch sheet which is thin and pliable used for testing paint samples allows for paint to be placed on the viewable surface and prevents curling of the surface. A unique combination of a latex impregnated saturated paper, an acrylic microsphere adhesive and a release liner are provided, allowing for a substantially thin and pliable swatch to be applied on a flat or any other contoured or corner surface and be easily removed therefrom.
US08927076B2 Article comprising light absorbent composition to mask visual haze and related method
A transparent article includes a continuous polyester matrix having at least one incompatible filler dispersed therein. The incompatible filler provides domains in the polyester matrix, each domain having a particular dimension, thus providing a range of dimensions for the domains in the article. To create haze, the dimensions are within the range of from about 380 nm to about 720 nm. Once the range of dimensions is determined, a light absorbent composition can be found which absorbs light at a range of wavelengths that at least substantially covers the range of dimensions of the domains. In doing so, it has been found that the haze of the article can be substantially masked. Method for producing the article and for masking the haze are also provided.
US08927075B2 Food and beverage containers and methods of coating
Food and beverage containers and methods of coating are provided. The food and beverage containers include a metal substrate that is at least partially coated with a coating composition that includes a water-dispersible resin system and an aqueous carrier. The resin system includes an epoxy component and an acrylic component. In a preferred embodiment, the coating composition is at least minimally retortable when cured.
US08927072B2 Photonic crystal security device
An optically variable security device comprises a photonic crystal which, upon receipt of incident light, generates a first optical effect, and which, when the device is subjected-to-an external stimulus, generates a second optical effect that is different from the first optical effect. At least one of the first and second optical effects is an optically variable effect observable over a set of directions. The optically variable effect is caused by the light being selectively reflected or transmitted by the crystal.
US08927065B2 Process for producing continuous graphitic fibers from living graphene molecules
A process for producing a continuous graphitic fiber, comprising: (a) preparing a graphene oxide gel having living graphene oxide molecules or functionalized graphene chains dissolved in a fluid medium; (b) depositing at least a continuous filament of graphene oxide gel onto a supporting substrate under a condition of stress-induced molecular alignment of living graphene oxide molecules along a filament axis direction; (c) removing the fluid medium to form a continuous graphene oxide fiber, having an inter-plane spacing d002 of 0.4 nm to 1.2 nm and an oxygen content no less than 5% by weight; and (d) heat treating the continuous graphene oxide fiber to form the continuous graphitic fiber at a temperature higher than 100° C. (preferably >600° C.) to an extent that an inter-plane spacing d002 is decreased to a value of 0.3354-0.4 nm and the oxygen content is decreased to less than 5% by weight.
US08927060B2 Method for forming Ge-Sb-Te film and storage medium
There is provided a method for forming a Ge—Sb—Te film having a composition of Ge2Sb2Te5 on a substrate by a CVD method using a gaseous Ge source material, a gaseous Sb source material and a gaseous Te source material. The method includes loading the substrate within a processing chamber (Process 1); performing a first stage film forming process on the substrate by supplying the gaseous Ge source material and the gaseous Sb source material (Process 2); and performing a second stage film forming process on a film obtained through the first stage film forming process by supplying the gaseous Sb source material and the gaseous Te source material (Process 3). The Ge—Sb—Te film is formed by the film obtained through Process 2 and by a film obtained through Process 3.
US08927059B2 Deposition of metal films using alane-based precursors
Methods of depositing pure metal and aluminum alloy metal films. Certain methods comprises contacting a substrate surface with first and second precursors, the first precursor comprising an aluminum precursor selected from dimethylaluminum hydride, alane coordinated to an amine, and a compound having a structure represented by: wherein R is a C1-C6 alkyl group, and the second precursor comprising a metal halide. Other methods relate to sequentially exposing a substrate to a first and second precursor, the first precursor comprising an aluminum precursor as described above, and the second precursor comprising Ti(NR′2)4 or Ta(NR′2)5, wherein R′ is an alkyl, alkenyl, alkynyl, keto or aldehyde group.
US08927055B2 Methods for depositing antireflective coating compositions
Coating compositions, and methods for depositing them on the surface of an article to produce an antireflection coating, are disclosed. In one embodiment, the coating composition includes a (meth)acrylate-functional silicon alkoxide, silica particles, a (meth)acrylate monomer, an epoxy (meth)acrylate oligomer, a photoinitiator, a solvent, an acid, and water. The relative amounts of these constituents are controlled such that, when the coating composition is deposited onto the surface of an article and cured, it has a refractive index less than about 1.60 at a wavelength of 510 nm. In another embodiment, the coating composition includes an organo-metallic compound other than an organo-metallic compound of silicon, an epoxy-functional silicon alkoxide, a non-epoxy-functional silicon alkoxide, a curing agent compatible with epoxy-functional molecules, a solvent, an inorganic acid, and water. The relative amounts of these constituents are controlled such that, when the coating composition is deposited onto the surface of an article and cured, it has a refractive index greater than about 1.70 at a wavelength of 510 nm. The coating compositions are deposited in a process that produces an antireflection coating in less than 90 minutes of processing time.
US08927043B2 Stabilized formulations of fatty acids
Disclosed herein are stabilized powder and aqueous formulations comprising a substantially water insoluble lipophilic bioactive compound and a micelle-forming surfactant. In one embodiment, the formulation further comprises a water soluble reducing agent, and/or a water insoluble reducing agent, and/or a metal chelator, and/or a metal bisulfite reducing agent, or combinations thereof, wherein the formulation remains substantially clear and stable when stored at or below room temperature for a period of at least 6 months or at least 12 months; and methods for preparing these formulations.
US08927031B2 Anti-glycation methods and compositions
The present invention comprises compositions that provide anti-glycation activity comprising a mineral extract composition or a mogroside/mineral extract composition or a mogroside composition. Such compositions are useful for methods of preventing, treating and inhibiting the effects of glycation in the body. The methods of the present invention comprise use of anti-glycation composition for the treatment and prevention of glycation related conditions including diabetes, atherosclerosis, arthritis, mental conditions and vision impairment.
US08927030B2 Use of nitrite salts for the treatment of cardiovascular conditions
It has been surprisingly discovered that administration of nitrite to subjects causes a reduction in blood pressure and an increase in blood flow to tissues. The effect is particularly beneficial, for example, to tissues in regions of low oxygen tension. This discovery provides useful treatments to regulate a subject's blood pressure and blood flow, for example, by the administration of nitrite salts. Provided herein are methods of administering a pharmaceutically-acceptable nitrite salt to a subject, for treating, preventing or ameliorating a condition selected from: (a) ischemia-reperfusion injury (e.g., hepatic or cardiac or brain ischemia-reperfusion injury); (b) pulmonary hypertension (e.g., neonatal pulmonary hypertension); or (c) cerebral artery vasospasm.
US08927028B2 Pharmaceutical composition containing coated, floating particles
A dosage form exhibiting delayed transit time through the GI tract. The dosage form comprises a plurality of buoyant particles, each comprising an inner drug-containing core, an intermediate layer surrounding said core and a release rate-controlling outer coating.
US08927022B2 Granules of porous biocompatible materials
The disclosure provides granular forms of porous biomaterials and methods for forming and applying these biomaterials, including uses to promote vascularization and tissue ingrowth.
US08927020B2 Method for producing biologically ingestible material and biologically ingestible material obtained therefrom
A production method is provided for obtaining a biologically ingestible material having an intended diameter with low energy as compared with conventional methods. The method includes mixing a fluid to be processed in a dispersed phase containing a pharmacologically active substance and a fluid to be processed in a continuous phase including at least a disperse solvent, while each of the fluids is retained in an independent state, in a thin film fluid formed between two processing surfaces arranged to be opposite to each other to be able to approach to and separate from each other, at least one of which rotates relative to the other, through independent pathways corresponding to the respective phases, whereby the components contained in the fluid to be processed in a dispersed phase are formed into microparticles having a desired diameter.
US08927019B2 Methods and compositions for treating recurrent cancer
The present invention provides methods of treating recurrent cancer (such as recurrent ovarian, peritoneal, or fallopian tube cancer) in an individual, comprising administering to the individual an effective amount of a composition (such as Nab-paclitaxel or Abraxane®) comprising nanoparticles comprising a taxane and a carrier protein.
US08927017B2 Pharmaceutical preparation containing gabapentin
A method for preparing a gabapentin granulate comprising melt granulating gabapentin with polyethylene glycol having a melting point comprised between 50 and 80° C.
US08927016B2 Producing a sustained-release preparation
This invention provides a production method for a solid sustained-release preparation, characterized in that a sustained-release preparation (a sustained-release preparation suspension) is freeze-dried in a freeze-drying container whose inner face is partially or totally coated with an ice layer or water-repelling base material.
US08927013B2 Misuse preventative, controlled release formulation
Disclosed is a misuse preventative, controlled release composition in the form of a multilayered oral dosage form. A first layer contains a plurality of controlled release microparticles having a pharmaceutically active agent (for example, an opioid analgesic) disposed therein. A second layer comprises a pharmaceutically active agent that can be the same or different from the pharmaceutically active agent in the microparticles. The composition further comprises a superabsorbent material disposed within the first layer, the second layer, or both the first layer and the second layer. When crushed, either intentionally or accidentally, and exposed to an aqueous medium, the superabsorbent material swells to encapsulate the microparticles, which remain substantially intact thereby retarding the release of the pharmaceutically active agent from the composition.
US08927012B2 Multi-vitamin and mineral nutritional supplements
The invention provides a nutritional supplement which includes micronutrients to facilitate reduction of cholesterol, and/or reduction of homocystein and/or reduction of low-density lipoprotein-cholesterol (LDL-C) oxidation in humans. In one embodiment the supplement is a multi-vitamin, a mineral supplement which includes at least one component known to reduce cholesterol. The invention further provides a method for tableting one fourth to one half of the daily effective dosage of a phytosterol containing nutritional supplement in a practical sized tablet and a method for reducing blood cholesterol in humans.
US08927004B1 Bioabsorbable substrates and systems that controllably release antimicrobial metal ions
Bioabsorbable substrates having antimicrobial metal ion coatings that are well suited for implantation in to a subject's body to treat and/or prevent infection. In particular, described herein are flexible bioabsorbable filaments that are coated with an anodic metal (e.g., silver and/or zinc and/or copper) that is co-deposited with a cathodic metal (e.g., palladium, platinum, gold, molybdenum, titanium, iridium, osmium, niobium or rhenium) on the filament so that the anodic metal is galvanically released as antimicrobial ions when the apparatus is inserted into a subject's body. The anodic metal may be at least about 30 percent by volume of the coating.
US08927001B2 Bioswellable, crystalline, amphiphilic, block/graft polymers and applications thereof
Absorbable, essentially non-absorbable, and non-absorbable crystalline, amphiphilic, block/graft copolymeric compositions exhibit an inherent viscosity of at least 0.5 dL/g, a heat of fusion of at least 10 J/g and undergo swelling in the biological environment due to a water up-take of at least 10 percent of original dry mass. These compositions are designed for use in swellable surgical sutures, coatings of medical devices, and carriers for the delivery of bioactive agents.
US08926997B1 Polymeric biocidal salts
A polymeric biocidal salt is prepared from two components. The first component comprises a biocidal anionic or cationic monomeric, dendrimeric or polymeric ion. The second component comprises a dendrimeric or polymeric anion or cation having insignificant biocidal activity and a number average molecular weight of at least about 500. The second component will be cationic in nature when the first component is anionic in nature and anionic in nature when the first component is cationic in nature. The salt is further characterized as partially dissolving when exposed to an aqueous medium, thereby: (a) releasing sufficient biocidal ion to exceed the MIC or MBIC of a target bacteria sought to be controlled; and (b) leaving a reservoir of undissolved salt capable of being further dissolved and releasing additional biocidal ion as the biocidal ion is consumed or is otherwise removed from the environment encompassing the target bacteria.
US08926993B2 Methods and compositions using Listeria for enhancing immunogenicity by prime boost
Provided herein are prime-boost regimens and materials used therein. The prime-boost regimens enhance the immune response to a target antigen. The vaccines used for boost are comprised of recombinant attenuated metabolically active Listeria that encodes an expressible antigen that is cross-reactive with the target antigen. In some examples, the immune response is a cellular immune response.
US08926991B2 Botulinum toxin and the treatment of primary disorders of mood and affect
The invention provides methods for treating primary disorders of mood and affect, including depressive disorders, anxiety and sleep disorders and CNS disorders comprising the administration of a neurotoxin.
US08926990B2 Treatment and diagnosis of inflammatory disorders and HIV
This invention concerns compositions and methods of treating or diagnosing inflammatory disorders and other disorders, as well as compositions and methods of treating HIV.
US08926988B2 Mutant proteins of the F protein of PIV-5 and PIV-2
The present application concerns mutant proteins of the fusion protein (F protein) of the parainfluenza virus (PIV) which are currently indexed as type 5 PIV (PIV-5 or PIV5) and type 2 PIV (PIV-2 or PIV2). The present application concerns products deriving therefrom, such as: nucleic acids, vectors, cells, fusion inhibitors of the antibody, aptamer, interfering RNA type; myelomas, hybridomas; stem and progenitor cells. The present application also concerns mutant proteins and products derived therefrom for use in medical and biotechnological applications.
US08926987B2 Replication-competent adenoviral vectors
This invention provides improved replication-competent adenoviral vectors. The improved vectors have both a hybrid regulatory unit that provides for high level transgene expression. The vectors can be use, e.g., for therapeutic or prophylactic purposes.
US08926986B2 Use of saccharides cross-reactive with Bacillus anthracis spore glycoprotein as a vaccine against anthrax
Provided are immunogenic compositions and methods for eliciting an immune response against B. anthracis and other bacteria that contain 3-methyl-3-hydroxybutyrate- or 3-hydroxybutryate-substituted saccharides. Conjugates of 3-methyl-3-hydroxybutyrate- or 3-hydroxybutryate-substituted saccharides elicit an effective immune response against B. anthracis spores in mammalian hosts to which the conjugates are administered.
US08926985B2 Vaccine
The present invention relates to the field of bacterial polysaccharide antigen vaccines. In particular, the present invention relates to bacterial polysaccharides conjugated to protein D from H. influenzae.
US08926977B2 Antibodies to the E1 extracellular loop of ion channels
An anti-E1 ion channel antibody or binding fragment thereof, pharmaceutical compositions comprising said antibodies, use of the antibodies and compositions comprising the same, in treatment, for example in the treatment/modulation of pain and processes for generating and preparing said antibodies.
US08926974B2 Methods of treating a tauopathy
The present disclosure provides methods of treating a tauopathy, involving administering an anti-Tau antibody. The present disclosure also provides anti-Tau antibodies, and formulations comprising same, for use in the methods.
US08926970B2 Rspondin antibodies as inhibiting factors of angiogenesis and vaculogenesis
The present invention relates to the use of Rspondins, particularly Rspondin2 (Rspo2) or Rspondin3 (Rspo3) or Rspondin nucleic acids, or regulators or effectors or modulators of Rspondin, e.g. Rspo2 and/or Rspo3 to promote or inhibit angiogenesis and/or vasculogenesis, respectively. The invention is based on the demonstration that Rspo3 and Rspo2 are angiogenesis promoters, and the identification of Rspo2 and 3 as positive regulators of vascular endothelial growth factor (VEGF). These results indicate a major role for Rspondins, particularly Rspo3 and/or Rspo2 in the signaling system during angiogenesis. The invention also relates to the use of regulators or effectors or modulators of Rspondin3, including agonists and antagonists, in the treatment of conditions where treatment involves inhibiting or promoting angiogenesis and/or vasculogenesis.
US08926962B2 Treatment of plants against oomycete infection
Treatment of plants against infection by oomycetes. The invention refers to a new strain of Phoma useful for manufacturing a plant-care composition intended to treat plants against phytopathogenic oomycetes. This new strain was deposited on Feb. 25, 2010 with the Collection Nationale de Cultures de Microorganismes of the Institut Pasteur in Paris, France under the CNCM number I-4278.
US08926961B2 HPV E6 protein T cell epitopes and uses thereof
The present invention is directed to the examination of the pattern of immunodominant T cell epitopes in the E6 protein of Human Papilloma virus and its further characterization in terms of its amino acid sequence and Human Leukocyte Antigen restriction. These epitopes are identified based on their ability to induce specific T cell responses and therefore, are important as sources of antigens for immunotherapies to treat cervical and other cancers. The present invention contemplates identifying a number of similar epitopes restricted by a wide variety of Human Leukocyte Antigen types so that they can be used together to develop preventative or therapeutic vaccines, which can be used for the general human population. The present invention also contemplates using E6 peptides of Human Papilloma virus as a diagnosis method to predict the probability of developing persistent cervical neoplasia in an individual.
US08926958B2 Prevention and treatment of vascular disease with recombinant adeno-associated virus vectors encoding apolipoprotein A-I and apolipoprotein A-I milano
Described herein is a gene therapeutic approach to the prevention and treatment of vascular disease and coronary heart disease; in particular, atherosclerosis. The inventive methods may be used in the prevention and treatment of atherosclerosis, as well as any disease or physiological condition in which atherosclerosis plays a role. The inventive methods involve the gene delivery of ApoA-I or ApoA-IMilano. This may be accomplished by the use of rAAV technology. rAAV virions may be delivered to a mammalian subject by various methodologies, including transplantation of transduced bone marrow cells, direct intramuscular injection, intravenous or portal vein injection or stent delivery.
US08926952B2 Methods of use of probiotic bifidobacteria for human beauty benefits
Methods of use in humans of probiotic bacteria of the genus Bifidobacteria for regulating the condition of human keratinous tissue to achieve cosmetic beauty benefits. Said methods include regulation, either prophylactic or therapeutic, of the cosmetic appearance of human keratinous tissue, such as human hair, skin (e.g., scalp), and nails. In another aspect, the invention provides a method of marketing a composition comprising probiotic Bifidobacteria. In one embodiment, the method comprises: (1) offering for sale a composition comprising probiotic Bifidobacteria; and (2) communicating to a potential consumer of said composition that oral administration of said composition can regulate the condition of human keratinous tissue.
US08926951B2 Composition for preventing oral disease by penetrating polymicrobial oral biofilms and killing oral pathogens
A composition and method of stabilized chlorine dioxide at a concentration range of about 0.005% to about 0.800% (w/v) at a pH in the range of 6.0 to 7.4 for the prevention of oral diseases caused by dental biofilm and plaque accumulation, such as gingivitis and periodontitis, through bactericidal properties is disclosed. The bactericidal properties of stabilized chlorine dioxide are further expanded to include reduction (kill) of anaerobic/aerobic/facultative gram-negative and gram-positive oral bacteria occurring in plaque or polymicrobial biofilms. The composition may be in the form of wash, rinse, soak, paste, gel, aerosol spray, or other suitable delivery system.
US08926950B2 Oral care composition comprising stannous and nitrate ions
An oral care composition comprising a) an aqueous phase; b) stannous ions solvated in the aqueous phase; c) nitrates solvated in the aqueous phase; wherein the total content of said nitrates is such that the molar amount of nitrogen in the aqueous phase, measurable as nitrate, is less than 2 times the molar amount of solvated stannous ions; and d) a flavor substance, which is preferably solvated, dispersed or emulgated in the aqueous phase. Disclosed are also containers containing the composition; and processes and uses for stabilizing stannous ions against oxidation, using nitrates.
US08926945B2 Compounds comprising a biological target recognizing part, coupled to a signal part capable of complexing gallium
The invention concerns compounds comprising a biological target recognizing part, coupled to a signal part capable of complexing gallium. The invention also concerns methods for obtaining said compounds, screening methods capable of selecting such compounds for chemical synthesis thereof and their diagnostic applications, in particular in PET, PET/IRM, PET CT imaging.
US08926944B2 Radiolabeled prostate specific membrane antigen inhibitors
Compounds according to Formula I and Formula II are potent inhibitors of PSMA activity: The invention also provides pharmaceutical compositions of a complex of a radionuclide and a Formula I compound or a Formula II compound and methods of using the radionuclide complex of a Formula I compound or a Formula II compound for treating or diagnosis of a disease or a condition associated with PSMA activity.
US08926939B2 Neopolyols suitable for crystal growth modification in the Bayer process
The invention provides methods and compositions for the addition of a CGM to precipitation liquor of a Bayer process. The CGM comprises a neopolyol, an ester derived from a neopolyol, and/or an ether derived from a neopolyol. Optionally the CGM may comprise water and/or an antifoaming agent and/or a hydrocarbon carrier liquid. The CGM is quite effective and results in a significant increase in mean particle size of produced alumina crystals.
US08926936B2 Process for production of sulphuric acid
The invention relates to a condenser, having a process gas side and a heat transfer medium side said condenser being configured for feeding a hot process gas containing a condensable component to an inlet of the condensing side, and being further configured for withdrawing a cooled process gas from an outlet of the condensing side, and being even further configured for withdrawing a condensate in a position proximate to one end of the condenser, and said condenser having the process gas side divided in a process gas cooling zone configured for having a cool heat transfer medium inlet and a heated heat transfer medium outlet, and a process gas re-heating zone downstream the process gas cooling section, configured for re-heating of the process gas, as well as a processes for condensation and production of sulphuric acid employing such a condenser.
US08926935B2 Compression processes for graphene sheets
Processes for preparing or handling graphene sheets wherein low bulk density graphene sheets are compressed. The graphene sheets may be produced by a thermal treatment such as exfoliation of precursor or reduction or annealing of previously existing graphene sheets and conveyed in a closed system to a compression apparatus.
US08926930B2 Alkali metal salt of fluorosulfonyl imide, and production method therefor
The present invention provides an alkali metal salt of fluorosulfonyl imide having favorable heat resistance and a reduced content of specific impurities and a water content, and provides a method for producing an alkali metal salt of fluorosulfonyl imide, which is capable of easily removing a solvent from a reaction solution. An alkali metal salt of fluorosulfonyl imide of the present invention is represented by the following general formula (I) and has a mass loss rate of 2% or less when the alkali metal salt of fluorosulfonyl imide is kept at 100° C. for 8 hours under an air current. A method for producing an alkali metal salt of fluorosulfonyl imide of the present invention comprises a step of concentrating a solution of the alkali metal salt of fluorosulfonyl imide by bubbling a gas into a reaction solution containing the alkali metal salt of fluorosulfonyl imide, and/or concentrating a solution of the alkali metal salt of fluorosulfonyl imide by thin layer distillation.
US08926928B2 Process of removing HCN from flue gas
The invention includes a process for reducing the amount of HCN discharged to atmosphere from a FCC unit, having a regenerator and a means for collecting and supporting catalyst particles. The process comprises adding a catalyst to the regenerator flue gas prior to entering the collecting means and precipitating the catalyst in the collecting means to form a catalyst bed. Ammonia or ammonia precursor is optionally added to the flue gas. The flue gas HCN is reacted in the presence of water and oxygen in the flue gas, and optional ammonia or ammonia precursor, at 200° C. to 800° C. in the presence of the catalyst bed to reduce the HCN amount, and the flue gas containing a reduced amount of HCN is discharged to atmosphere. The catalyst is one or more supported transition or lanthanide metal catalysts. The process can also be utilized in any combustion process.
US08926927B2 Process for the removal of carbon dioxide from a gas
A process for the removal of co2 from a gas comprising the steps of: (a) contacting the gas (1) in an absorber (2) with an aqueous solution of one or more carbonate compounds in the presence of an accelerator, thereby reacting at least part of the co2 to form a bicarbonate compound, under conditions such that at least a part of the bicarbonate compound formed precipitates, forming a bicarbonate slurry; (b) subjecting at least part of the bicarbonate slurry to a concentration step (5) to obtain an aqueous solution (6) and a concentrated bicarbonate slurry (7), wherein the concentrated bicarbonate slurry comprises from 20 to 80 wt % of bicarbonate compounds; (c) returning at least part of the aqueous solution to the absorber; (d) pressurising (8) the concentrated bicarbonate slurry, (e) transferring the pressurized concentrated bicarbonate slurry to a regenerator (12) and applying heat to obtain a co2-rich gas stream (13) and a regenerated carbonate stream (14).
US08926923B2 Biocontainer transfer assembly
The present invention relates to pharmaceutical fluids, and more particularly to a flexible container for aseptic transfer and/or mixing of pharmaceutical fluids. A biocontainer for the transfer of pharmaceutical fluids includes a flexible layer divided by a fold line into a front face and a rear face. The layer is folded about the fold line such that the front face and the rear face are facing each other to define an interior space between them. The biocontainer also includes a seam that connects the front and rear faces to each other to close the interior space. A fill port is also provided to communicate with the interior space. This fill port is intersected by the fold line.
US08926921B2 Analysis unit intended to be used in analysis apparatus
This analysis package comprises: a cartridge (3) for reactive products comprising several recipients (4) for reactive products arranged one above the other, wherein each recipient comprises a neck (6), wherein the neck of each recipient is provided with a closing device (7) and a plate (13) for receiving the cartridge (3), wherein the plate comprises a receptacle (22) which is open to the top for receiving the bases of the recipients (4) for reactive products which bases form the cartridge; and means for keeping the recipients for reactive products in position situated in distance from the receptacle, wherein the position keeping means are organized such that they cooperate with the necks of the recipients for reactive products when the bases of said recipients are received in the receptacle (22).
US08926918B2 Isothermal multitube reactors
The present invention provides isothermal multitube reactors suitable for the production of chlorinated and/or fluorinated propene and higher alkenes from the reaction of chlorinated and/or fluorinated alkanes and chlorinated and/or fluorinated alkenes. The reactors utilize a feed mixture inlet temperature at least 20° C. different from a desired reaction temperature.
US08926916B2 Process and apparatus for recovery of dichlorohydrins via codistillation
A process and apparatus for recovering dichlorohydrins from a mixture comprising dichlorohydrins, one or more compounds selected from esters of dichlorohydrins, monochlorohydrins and/or esters thereof, and multihydroxylated-aliphatic hydrocarbon compounds and/or esters thereof, and optionally one or more substances comprising water, chlorinating agents, catalysts and/or esters of catalysts is disclosed. The mixture is stripped to recover dichlorohydrin(s) while distilling or fractionating the mixture to separate a lower boiling fraction comprising dichlorohydrin(s) from the mixture in one step. Advantages include more efficient recovery of dichlorohydrins for a given distillation column, less waste due to avoiding the conditions conducive to the formation of heavy byproducts, and reduced capital investment in recovery equipment.
US08926915B2 Smell-diffusing cell array substrate, apparatus for transferring smell information and electronic device including the apparatus
A smell-diffusing cell array substrate, an apparatus configured to transfer smell information and an electronic device are provided, the smell-diffusing cell array substrate includes at least one smell-diffusing cell having a microcapsule with a core-shell structure. A shell of the microcapsule includes a wall material and a photocatalyst dispersed in the wall material. A core of the microcapsule includes a smell-diffusion material and a hydrophilic liquid.
US08926914B2 Liquid medium plasma discharge generating apparatus
A liquid medium plasma discharge generating apparatus includes a main body; a power electrode, provided at one side within the main body, for receiving electric power; a diaphragm member provided within the main body, and consisting of a dielectric defining one or more holes or slits; and a liquid medium charged inside the main body, wherein a ground electrode may be further provided in the main body, opposite the power electrode with the diaphragm member therebetween, whereupon the diaphragm member is arranged contacting the ground electrode.
US08926913B2 Particulate filter with low soot loaded coating
A ceramic particulate filter having a porous catalytic material deposited on walls within the filter. Particulate matter is trapped in the walls of the filter and the catalytic material removes gases, such as nitrogen oxides (NOx), from gases passing through the filter. The filter, in one embodiment, is adaptable for use with internal combustion (gas and diesel) engines. A method of making the filter is also described.
US08926911B2 Use of microspheres in an exhaust gas treatment device mounting mat
A mounting mat for an exhaust gas treatment device including inorganic fibers, organic binder, high temperature resistant inorganic microspheres, and optionally intumescent material. The exhaust gas treatment device includes a housing, a fragile catalyst support structure resiliently mounted within the housing, and the mounting mat disposed in a gap between the housing and the fragile catalyst support structure.
US08926910B2 Hydrocarbon trap for reducing cold-start engine emissions
A hydrocarbon trap is provided for reducing cold-start hydrocarbon emissions. The trap contains an acidic absorption material for improving absorption of low molecular weight hydrocarbons. The acidic absorption materials may be used either alone or in combination with zeolites which are integrated into and/or supported on a monolithic substrate. The hydrocarbon trap may be positioned in the exhaust gas passage of a vehicle such that hydrocarbons are adsorbed on the trap and stored until the engine and exhaust reach a sufficient temperature for desorption.
US08926905B2 Optical lens system and method for microfluidic devices
An apparatus for imaging one or more selected fluorescence indications from a microfluidic device. The apparatus includes an imaging path coupled to least one chamber in at least one microfluidic device. The imaging path provides for transmission of one or more fluorescent emission signals derived from one or more samples in the at least one chamber of the at least one microfluidic device. The chamber has a chamber size, the chamber size being characterized by an actual spatial dimension normal to the imaging path. The apparatus also includes an optical lens system coupled to the imaging path. The optical lens system is adapted to transmit the one or more fluorescent signals associated with the chamber.
US08926899B1 Photocatalytic devices
Photocatalytic devices are described. In some embodiments, a photocatalytic device may include a cylindrical housing having an inlet opening and an outlet opening; one or more catalyst substrates disposed within the cylindrical housing and adapted to support a hydroxyl radical reaction with ultraviolet light and water vapor that results in hydro peroxides and hydroxyl ions; an ultraviolet light source disposed within the cylindrical housing and adapted to provide the ultraviolet light to the one or more catalyst substrates; and a fan disposed within the cylindrical housing and adapted to cause air to enter the cylindrical housing via the inlet opening, circulate through the one or more catalyst substrates within the cylindrical housing, and exit the cylindrical housing via the outlet opening. The catalyst substrates comprising a hydrated multi-metallic catalyst having two or more elements selected from the group: Titanium dioxide, Platinum, Gold, Silver, Copper, Rhodium, Ruthenium, Lanthanum, Carbon and Fluoride.
US08926896B2 Method of compacting a first powder material and a second powder material
One embodiment includes providing a first layer including a first powder material and a second layer including a second powder material over the first layer, and compacting the first powder material and the second powder material using at least a first magnetic field.
US08926893B2 Casting shroud, manipulation device for this shroud, and device for driving a valve
A manipulation device for a shroud for casting liquid metal comprises holding means for the shroud, downstream of a metal flow control valve, this valve being able to assume an open configuration and a closed configuration under the action of drive means. The manipulation device comprises fixing means affixed to the drive means for the valve. A ladle shroud for the flow of liquid metal from a casting ladle to a metal tundish has a longitudinal axis and comprises a shroud gripping head at one end. The gripping head is fusiform.
US08926892B2 Recuperated isothermal melter and related methods
An energy efficient metal melter has a portion of melting energy supplied to it by a combustion process for heating a melter charge to a temperature where the melter charge can no longer maintain its shape. A portion of melting energy is also supplied by an electrical process for adding remaining transformational and sensible heat. The combustion process preferably uses a hydrocarbon fuel energy source selected from a distillate compound, gas compound or both and the electrical energy comes from a source selected from an external power grid, a generator and combinations thereof.
US08926891B2 Method for manufacturing ceramic honeycomb fired body
Manufacture of ceramic honeycomb fired body. Green molded body is placed on a firing base and fired. The firing base and green molded body are each a column containing a ceramic raw material and having a partition wall forming a plurality of flow paths, and patterns of end surfaces of the two partition walls are the same as each other as seen from an extending direction of the flow paths. The green molded body is placed on the firing base displaced in a horizontal direction by a predetermined distance, or rotated around a vertical axis V of the green molded body by a predetermined angle θ, so that only a part of the lower side end surface of the partition wall of the green molded body is in contact with the upper side end surface of the partition wall of the firing base.
US08926890B2 Process for making an embossed web
A process for making an embossed web. A precursor web is provided between a forming structure and a static pressure plenum. The forming structure has a plurality of discrete protruded elements. Pressure is provided by the static pressure plenum against the precursor web and the forming structure to conform the precursor web to the discrete protruded elements of the forming structure to form the embossed web. The resulting embossed web has a plurality of discrete extended elements having open proximal ends.
US08926888B2 Fluorinated silazane release agents in nanoimprint lithography
An imprint lithography release agent having general formula (1): where R1 represents H or CH3, n is an integer from 1 to 5, and m is an integer from 1 to 40. Fluorinated silazanes of general formula (1) can be used to form a release layer on an imprint lithography template, added to an imprint lithography resist, or both.
US08926886B2 Multichannel collagen nerve conduit for nerve repair
The present invention relates to the fabrication of multichannel nerve conduits for use in the repair of nerve injury. In particular, the invention relates to collagen multichannel nerve conduits which are suitable for use in repair of peripheral nerves.
US08926885B2 Method of molding boot for constant velocity joint
A method of molding a boot for a constant velocity joint includes: molding a compact by injection molding; raising split dies of an inner die so as to separate the split dies from a set ring; raising a core shaft of the inner die so as to separate the core shaft from the split dies; separating each of the split dies from the compact; introducing a lower end portion of the separated split die into the set ring along an engaging surface; and inserting a lower end portion of the core shaft through the set ring from above the set ring, and pressing upper end portions of the split dies downward by a protruding portion at an upper end portion of the core shaft so that the lower end portions of the split dies are engaged with the engaging surface and the split dies are brought into close contact.
US08926883B2 Forming apparatus
The present invention relates to method of forming a material, including the steps of, presenting a formable material to a space from where the material can be carried by and/or between opposing surfaces of the space, as the opposing surfaces advance in an advancing direction. Also pressurising, as the opposing surfaces advance, the material between the opposing surfaces in a reduced space between the opposing surfaces defining at least in part a pressure forming zone. The reduced space between the opposing surfaces being maintained at least substantially constant until such time as the form of at least one of the opposing surfaces is profiled into the material and is retainable thereon. Thereafter releasing the now profiled material from between the opposing surfaces, as the space increases between the opposing surfaces as the surfaces advance. The relative movement between adjacent tools of at least one set of forming tools over the zone before the pressure forming zone is only towards the forming tools of the other opposing surface.
US08926870B1 Mixed-layered bismuth—oxygen—iodine materials for capture and waste disposal of radioactive iodine
Materials and methods of synthesizing mixed-layered bismuth oxy-iodine materials, which can be synthesized in the presence of aqueous radioactive iodine species found in caustic solutions (e.g. NaOH or KOH). This technology provides a one-step process for both iodine sequestration and storage from nuclear fuel cycles. It results in materials that will be durable for repository conditions much like those found in Waste Isolation Pilot Plant (WIPP) and estimated for Yucca Mountain (YMP). By controlled reactant concentrations, optimized compositions of these mixed-layered bismuth oxy-iodine inorganic materials are produced that have both a high iodine weight percentage and a low solubility in groundwater environments.
US08926869B2 Method and composition for recoating toner cartridge developing member
Methods of recoating a developing member such as the doctor blade, developing member bar or a developing sleeve, of an electro-photographic image forming apparatus, such as a laser printer toner cartridge, methods of re-using the original components by re-coating them, to cut the cost of using new aftermarket parts and to reduce waste, which methods include close quality control and “tailoring” of formulations to a specific developing system, thus achieving better print quality in terms of density, page yield, and uniformity for the repaired or remanufactured toner cartridge.
US08926866B2 Hydrogen generating apparatus using steam reforming reaction
The present invention provides a hydrogen generator for generating hydrogen through a steam-reforming process using hydrocarbons as a raw material and a method of operating the same, and, more particularly, provides a hydrogen generator for generating hydrogen through a steam reforming process, which can be stably operated because water is introduced into the hydrogen generator in the form of single phase vapor, and which can achieve high thermal efficiency using a proper heat exchanging method, and to a method of operating the same. According to the present invention, there is provided a heat exchanger network, in which heat necessary for a reforming reaction are obtained by the heat exchange of high-temperature exhaust gas or reformed gas, and in which, in a water gas converting reaction and a PSA reaction conducted at low temperatures compared to the reforming reaction, heat exchange is performed by low-temperature air or water, and the heat-exchanged air and the residual gas in the PSA reaction are used as a heat supply source for the reforming reactor together with fuel hydrocarbons, thereby minimizing the thermal loss of the hydrogen generator.
US08926863B2 Process for producing fluorescent substance and fluorescent substance produced thereby
The present invention provides a fluorescent substance excellent both in quantum efficiency and in temperature characteristics, and also provides a process for producing the fluorescent substance. This fluorescent substance is an oxynitride phosphor having a low paramagnetic defect density and comprising aluminum, silicon, either or both of oxygen and nitrogen, and a metal element M, provided that the metal element M is partly replaced with an emission center element R. That phosphor can be produced by the steps of: subjecting a mixture of starting materials to heat treatment under a nitrogen atmosphere so as to obtain an intermediate fired product, and then further subjecting the intermediate fired product to heat treatment under an atmosphere of nitrogen-hydrogen mixed gas.
US08926862B2 Low naphthenic liquid crystalline polymer composition for use in molded parts with a small dimensional tolerance
A thermoplastic composition that comprises a low-naphthenic, thermotropic liquid crystalline polymer blended with a combination of flow modifiers is provided. More particularly, one of the flow modifiers is a hydroxy-functional compound that contains or more hydroxyl functional groups. Without intending to be limited by theory, it is believed that the hydroxyl functional groups can react with the polymer chain to shorten its length and thus reduce melt viscosity. Aromatic dicarboxylic acids are also employed as a flow modifier in the thermoplastic composition. Again, without intending to be limited by theory, it is believed that such acids can combine smaller chains of the polymer together after they have been cut by hydroxy-functional compounds. This helps maintain the mechanical properties of the composition even after its melt viscosity has been reduced.
US08926859B2 Polishing composition for silicon wafers
A polishing composition for a silicon wafer includes a macromolecular compound, an abrasive, and an aqueous medium. The macromolecular compound includes a constitutional unit (a1) represented by the following general formula (1), a constitutional unit (a2) represented by the following general formula (2), and a constitutional unit (a3) represented by the following general formula (3). The total of the constitutional unit (a3) is 0.001 to 1.5 mol % of all the constitutional units of the macromolecular compound.
US08926858B2 Method of forming cryogenic fluid composition
A method of forming a machining spray for treating a surface of a substrate during a machining process includes providing a first component containing solid carbon dioxide particles. A second provided component is derived from an inert gas having a temperature range from 305 K to about 477 K prior to being mixed with the solid carbon dioxide particles. The first component and the second component are combined to form the cryogenic fluid composition prior to contacting the substrate. An optional additive may be mixed with the solid carbon dioxide particles or the inert gas. The cryogenic fluid composition exhibits synergistically enhanced physicochemical properties of each component not observed prior to the combination thereof, wherein the fluid imparts enhanced cooling, heating or lubrication effects.
US08926857B2 Lubricant for compression refrigerating machine and refrigerating apparatus using the same
The present invention provides a lubricating oil for a compression type refrigerator including a polyvinyl ether-based compound which containing an alkylene glycol or polyoxyalkylene glycol unit and a vinyl ether unit in a molecule and having a molecular weight in a range of 300 to 3,000 and one or more kinds of phosphorous compound selected from a phosphate having 25 or more carbon atoms, a phosphite having 10 to 60 carbon atoms, an amine salt of phosphate having 10 to 60 carbon atoms, and a metal salt of phosphate having to 60 carbon atoms. The lubricating oil for a compression type refrigerator of the present invention has high compatibility and high viscosity index, and is excellent in anti-seizure property and also in stability under carbon dioxide atmosphere.
US08926856B2 Heat transfer compositions
A heat transfer composition comprising trans-1,3,3,3-tetrafluoropropene (R-1234ze(E)), difluoromethane (R-32) and 1,1-difluoroethane (R-152a).
US08926855B2 Building materials, compositions, and methods
Building materials include a dampening layer which contains a plaster and a viscoelastic polymer, such as polyvinyl butyral. The dampening layer may also include a barium salt. Methods of making a sound dampening material include providing a plaster mixture. The mixture may include a viscoelastic polymer and/or a barium salt. The plaster mixture is combined with water and/or a viscoelastic polymer dispersion, to form a slurry. The slurry is applied to a surface and set to form a sound dampening layer.
US08926851B2 Method for making a film of uniformly arranged core-shell nanoparticles on a substrate
A method for making a film of core-shell nanoparticles generally uniformly arranged on a substrate uses atomic layer deposition (ALD) to form the shells. The nanoparticle cores are placed in a solution containing a polymer having an end group for attachment to the cores. The solution is then applied to a substrate and allowed to dry, resulting in the nanoparticle cores being uniformly arranged by the attached polymer chains. ALD is then used to grow the shell material on the cores, using two precursors for the shell material that are non-reactive with the polymer. The polymer chains also form between the cores and the substrate surface, so the ALD forms shell material completely surrounding the cores. The uniformly arranged core-shell nanoparticles can be used as an etch mask to etch the substrate.
US08926850B2 Plasma processing with enhanced charge neutralization and process control
Plasma processing with enhanced charge neutralization and process control is disclosed. In accordance with one exemplary embodiment, the plasma processing may be achieved as a method of plasma processing a substrate. The method may comprise providing the substrate proximate a plasma source; applying to the plasma source a first RF power level during a first period and a second RF power level during a second period, the first and second RF power levels being greater than zero RF power level, wherein the second RF power level is greater than the first RF power level; generating with the plasma source a first plasma during the first period and a second plasma during the second period; and applying to the substrate a first bias voltage during the first period and a second bias voltage during the second period, wherein the first voltage has more negative potential than the second voltage.
US08926845B2 Additive dispersing filter and method
A method and apparatus for dispersing an additive from an additive cartridge disposed in a housing of an oil filter is provided. The method including the steps of: using stagnation pressure to disperse the additive from the additive cartridge; and regulating a flow rate of the additive from the additive cartridge by restricting an inlet opening of an outlet path of the additive cartridge, wherein a portion of the outlet path is formed in a surface of a first piece of a two piece connector providing fluid communication between and an interior and an exterior of the additive cartridge.
US08926834B2 Probe for water treatment
A water treatment sensor includes a housing having a bottom with an exterior surface in contact with a flow path of a fluid and an interior surface. First and second probes spaced from one another extend from the exterior surface and into the flow path. A first circuit electrically connects the first and second probes and determines a conductivity from a measured resistivity between the probes. First and second temperature sensors are spaced from one another and are coupled to the interior surface. The first sensor determines a temperature of the fluid. A temperature elevated by a heat source and determined by the second sensor is maintained above the temperature of the fluid. A second circuit determines a flow rate of the fluid based on adjustments to the heat source. Communication circuitry communicates the conductivity, the temperature, and the flow rate of the fluid to a controller.
US08926826B2 Liquid-full hydroprocessing to improve sulfur removal using one or more liquid recycle streams
The present invention provides a process for hydroprocessing hydrocarbons in liquid full reactors with one or more independent liquid recycle streams. The process operates as a liquid-full process, wherein all of the hydrogen dissolves in the liquid phase and one or more of the recycle streams may actually be zero. Hydrocarbons can be converted in the process to provide liquid products such as clean fuels with multiple desired properties.
US08926824B2 Process for the conversion of residue integrating moving-bed technology and ebullating-bed technology
The invention describes a process for the conversion of heavy carbon-containing fractions having an initial boiling point of at least 300° C. to upgradable lighter products, said process comprising passage of said feed through a hydrorefining reaction zone comprising at least one moving-bed reactor, and passage of at least a portion of the effluent from stage a) through a hydroconversion reaction zone comprising at least one three-phase reactor, in the presence of hydrogen, said reactor containing at least one hydroconversion catalyst and operating in ebullating-bed mode, with an ascending current of liquid and gas and comprising at least one means of withdrawing said catalyst out of said reactor and at least one means of adding fresh catalyst into said reactor, under conditions making it possible to obtain a liquid feed with a reduced content of Conradson carbon, metals, sulphur and nitrogen.
US08926810B2 Reference electrode
A reference electrode, especially for a potentiometric measuring cell, comprising: a housing, which surrounds a housing interior, which contains a reference electrolyte and at least a part of a sensing system for sensing a potential of the reference electrode. The reference electrolyte is in contact with a medium surrounding the housing, especially a measured medium, via at least one bore traversing through a housing wall of the housing, and wherein the bore has an inner diameter of no more than 50 μm at its narrowest point and a length of no more than 200 μm.
US08926805B2 Method and apparatus for electroplating on SOI and bulk semiconductor wafers
An electroplating apparatus and method for depositing a metallic layer on the surface of a wafer is provided wherein said apparatus and method do not require physical attachment of an electrode to the wafer. The surface of the wafer to be plated is positioned to face the anode and a plating fluid is provided between the wafer and the electrodes to create localized metallic plating. The wafer may be positioned to physically separate and lie between the anode and cathode so that one side of the wafer facing the anode contains a catholyte solution and the other side of the wafer facing the cathode contains an anolyte solution. Alternatively, the anode and cathode may exist on the same side of the wafer in the same plating fluid. In one example, the anode and cathode are separated by a semi permeable membrane.
US08926804B2 Container for activation of drinkable liquids
A fluid container with an output of drinkable activated and vitalized fluids, preferably activated and vitalized water, preferably for fluid intake, includes a hollow body with an opening for filling fitted with a connector connecting an openable cap. An outlet for the bottle is provided for dispensing the fluid. The outlet is fitted with a galvanic processing device for galvanic fluid treatment of the fluid and to produce a swirling motion of the fluid.
US08926796B2 Bulk and stiffness enhancement in papermaking
The present invention provides formulations for papermaking and methods for their use. In embodiments, the formulations include a treatment agent and a fluid carrier, where the treatment agent includes a volatile debonder or a polymer composition exhibiting a lower critical solution temperature. Methods for treating a paper product to increase its bulk or its stiffness are also disclosed, in addition to paper products formed from such methods.
US08926795B2 Method for using washer press with multiple nips and multiple displacement wash zones
A method for using a washer press for washing and dewatering a wide range of solids concentrations of pulp in liquid suspensions includes multiple distinct displacement wash zones about a drum with multiple nips.
US08926791B2 Wastewater sludge treatment device
A tank or bed has a plurality of sidewalls that create a bed cavity and a Fresnel panel frame that includes at least one Fresnel panel. The Fresnel panel frame may be adjacent to the bed cavity and may cover at least a portion of the bed cavity. An amount of sludge may be contained within the bed cavity. When placed in sunlight, the heat enhanced by the Fresnel panels may heat the sludge sufficiently for the sludge to be used as fertilizer.
US08926790B2 Plasma processing apparatus
The invention provides a plasma processing apparatus aimed at suppressing the corrosion caused by reactive gas and heavy-metal contamination caused by plasma damage of components constituting the high-frequency electrode and gas supply unit. The plasma processing apparatus comprises a processing chamber 1 for subjecting a processing substrate 4 to plasma processing, gas supply means 17, 16 and 11 for feeding gas to the processing chamber 1, and an antenna electrode 10 for supplying high-frequency radiation for discharging the gas to generate plasma, wherein the gas supply means includes a gas shower plate 11 having gas discharge holes on the surface exposed to plasma, and a portion of or a whole surface of the conductor 10 exposed to gas constituting the antenna-electrode side of the gas supply means is subjected to ceramic spraying containing no heavy metal to form a protecting film 12.
US08926788B2 Closed chamber for wafer wet processing
An improved design for a closed chamber process module for single wafer wet processing utilizes a combination lid and gas showerhead for sealing the chamber from above. One or more media arms dispense liquid onto a wafer in the chamber. The media arms are mounted inside the chamber but are connected by a linkage that passes through the chamber wall to a drive unit mounted outside the chamber.
US08926786B1 Composite panel and method of manufacturing the same
A method of manufacturing a composite panel is described. The method includes pre-stabilizing a honeycomb core with at least one layer of a pre-stabilizing material, surrounding the honeycomb core with at least one composite laminate skin layer, and curing the at least one composite laminate skin layer.
US08926775B2 Method and device for bonding two wafers
A device for bonding of two wafers on one joining surface V of the wafers. The device includes a pressure transfer means with a pressure surface D for applying a bond pressure to the two wafers on the pressure surface D, wherein the pressure surface D is smaller than the joining surface V. The invention also relates to a method for bonding of two wafers on one joining surface V of the two wafers, by pressure transfer means with a pressure surface D for action on the wafers (2, 3), wherein a bond pressure is applied in succession to partial sections of the joining surface V.
US08926770B2 Method of hot stamping galvanized steel sheet
In a cooling a galvanized steel sheet (W), change in emissivity of a surface of the galvanized steel sheet (W) is measured in a temperature range lower than the boiling point of zinc but not lower than the ferrite transformation temperature, using an emissivity sensor (4) with an observation wavelength of 1.4 μm or longer, and pressing and quenching in a pressing and quenching apparatus (2) is started after completion of an alloying reaction has been detected based on the change in emissivity. The emissivity sensor (4) preferably has an InGaAs element or a thermopile as a measuring element.
US08926767B2 Steel part for machine structural use and manufacturing method thereof
The present invention provides a steel part for machine structural use whose fatigue strength and toughness are improved and a manufacturing method thereof. A steel part made of a steel containing, in mass %, C: 0.05 to 0.20%, Si: 0.10 to 1.00%, Mn: 0.75 to 3.00%, P: 0.001 to 0.050%, S: 0.001 to 0.200%, V: exceeding 0.25 to 0.50%, Cr: 0.01 to 1.00%, Al: 0.001 to 0.500%, and N: 0.0080 to 0.0200%, and a balance being composed of Fe and inevitable impurities, in which a steel structure contains a bainite structure having an area ratio of 95% or more, a bainite lath width is 5 μm or less, V carbide having an average grain diameter of not less than 4 nm nor more than 7 nm dispersedly exists in the bainite structure, and an area ratio of V carbide in the bainite structure is 0.18% or more.
US08926764B2 Hose handling system and methods of use
Embodiments of the present invention include a hose handling system having a hose guide plumbed via a wash line to a fluid delivery device. The hose guide includes a pulley installed on a frame member, and a spray nozzle adapted to dispense a wash mixture. The hose guide is adapted to guide a hose as the hose is inserted into or withdrawn from a manhole, with the hose traversing the pulley. The wash mixture can be delivered through a wash line to the hose guide, which sprays the wash mixture on the hose in order to reduce or eliminate gross contamination or microbial contamination on the hose. The wash mixture typically, but not necessarily, has a freezing point below 32 F and includes: a quaternary ammonium compound, an alcohol or glycol, an alcohol ethoxylate, and a fragrance.
US08926763B2 Method for cleaning internal parts of gasoline engines
Interior parts of gasoline engines are readily cleaned by a method comprising the steps of connecting an a cleaning liquid supply pipe having a gas supply port thereon airtightly to a port of an intake pipe of the engine below a throttle valve-attached position of the engine; operating the engine to draw cleaning liquid in the form of liquid drop and simultaneously drawing continuously a gas having an oxygen concentration of less than 20 vol. % into the intake pipe; and exhausting the cleaning liquid having been brought into contact with the internal parts of the engine with an exhaust gas.
US08926759B2 Manufacturing method of a glass substrate for a magnetic disk
An object of the invention is to remove effectively metallic contaminants adhering to the glass substrate surfaces without increasing roughness of the glass substrate surfaces in the glass substrate for a magnetic disk. In a manufacturing method of a glass substrate for a magnetic disk, a cleaning step comprising a treatment of contacting the glass substrate with a cleaning liquid containing peroxodisulfate and having a pH of not less than 2 and not more than 4 is appended. In addition, an example of the cleaning liquid can be prepared by adding sodium peroxodisulfate to an acidic solution.
US08926758B2 Composition and method for removing photoresist and bottom anti-reflective coating for a semiconductor substrate
A composition for removing photoresist and bottom anti-reflective coating from a semiconductor substrate is disclosed. The composition may comprise a nontoxic solvent, the nontoxic solvent having a flash point above 80 degrees Celsius and being capable of dissolving acrylic polymer and phenolic polymer. The composition may further comprise Tetramethylammonium Hydroxide (TMAH) mixed with the nontoxic solvent.
US08926757B2 Plasma process and reactor for treating metallic pieces
The plasma reactor defines a reaction chamber provided with a support for the metallic pieces and an anode-cathode system, and a heating means is mounted externally to said plasma reactor. The plasma process, for a cleaning operation, includes the steps of connecting the support to the grounded anode and the cathode to a negative potential of a power source; feeding an ionizable gaseous charge into the reaction chamber and heating the latter at vaporization temperatures of piece contaminants; applying an electrical discharge to the cathode; and providing the exhaustion of the gaseous charge and contaminants. A subsequent heat treatment includes the steps of: inverting the energization polarity of the anode-cathode system; feeding a new gaseous charge to the reaction chamber and maintaining it heated; applying an electrical discharge to the cathode; and exhausting the gaseous charge from the reaction chamber.
US08926754B2 Epitaxial growth susceptor
A susceptor for use in an epitaxial growth apparatus and method where a plurality of circular through-holes are formed in the bottom wall of a pocket in an outer peripheral region a distance of up to about ½ the radius toward the center of the circular bottom wall. The total opening surface area of these through-holes is 0.05 to 55% of the surface area of the bottom wall. The opening surface area of each of the through-holes provided at this outer peripheral region is 0.2 to 3.2 mm2 and the density of the through-holes is 0.25 to 25 per cm2. After a semiconductor wafer is mounted in the pocket, epitaxial growth is carried out while source gas and carrier gas (i.e., reactive gas) is made to flow on the upper surface side of the susceptor and carrier gas is made to flow on the lower surface side.
US08926748B2 Matting agent
A matting agent useful for the preparation of matted coatings comprising, inorganic oxide particulates; and wax coated on the inorganic oxide particulates, wherein the wax possesses a crystallinity of about 50% or more and said wax is present in an amount ranging from 15 wt % to 30 wt % based on a total weight of said matting agent.
US08926747B2 Preparation of coating dispersions
The invention relates to a process for the preparation of coating dispersions for use in the paper industry by co-grinding natural calcium carbonate (GCC) and precipitated calcium carbonate (PCC), characterized in that powdery GCC is co-ground with a slurry containing from 5 to 70% by weight of PCC to obtain a particle size distribution of the calcium carbonate with at least 90% by weight of smaller than 5 μm, at least 70% by weight of smaller than 2 μm, and at least 20% by weight of smaller than 1 μm, with a weight average particle size within a range of from 0.7 to 3 μm.
US08926738B2 Brake pad assembly and method for collecting brake particles
A disk brake pad (11) comprising a supporting base (13) with which a layer (15) of friction material is associated, characterized in that a wall (19) of said supporting base having associated therewith the layer of friction material is passed through by at least one channel (21, 23, 41) communicating with a chamber (17a, b), defined in correspondence of the supporting base, for collecting the powders produced due to the wear of the friction material.
US08926736B2 Reducible porous crystalline hybrid solid for the separation of mixtures of molecules having different degrees and/or a different number of unsaturations
The present invention relates to reducible porous crystalline solids, constituted of a metal-organic framework (MOF), for the separation of mixtures of molecules having different unsaturation degrees and/or a different number of unsaturations with a selectivity that can be adjusted by controlling the reduction of the MOF. The MOF solids of the present invention, after reduction, have a strong affinity for molecules containing at least one unsaturation. They can be used in various separation processes, especially those relating to hydrocarbons.
US08926735B1 Separation of gases using zeolite SSZ-45
This disclosure relates generally to the selective separation of carbon dioxide (CO2) from multi-component gas streams containing CO2 utilizing zeolite SSZ-45 as an adsorbent.
US08926734B2 Induced-draft injection systems and methods
An exemplary embodiment of the present invention provides an induced-draft injection system comprising an injection line in fluid communication with a duct under negative pressure, a particulate storage containing particulate, and a feeder receiving the particulate from the particulate storage and feeding the particulate to the injection line. The negative pressure in the duct supports the transportation of at least a portion of the particulate through the injection line and into the duct. Inside the duct, a binding portion of the particulate is bound to a portion of mercury in a flue gas passing through the duct, thus enabling a portion of the mercury to be filtered out of the flue gas.
US08926729B2 Method and apparatus for direct reduction ironmaking
An apparatus for producing a reducing gas for direct reduction iron-making includes an internal-heating type reformer for reforming a natural gas by adding steam and oxygen to the natural gas and by partially burning the natural gas to generate reducing gas containing hydrogen and carbon monoxide; a remover for removing carbon dioxide from exhaust gas generated in the direct reduction iron-making; and a line for recycling as the reducing gas the exhaust gas from which the carbon dioxide is removed by the remover.
US08926726B2 Exhaust gas purification device
A exhaust gas purification device is structured such that it is possible to improve an assembling work ability or a maintenance work ability of gas purifying bodies or exhaust gas purifying cases. In an exhaust gas purification device provided with gas purifying bodies which purify an exhaust gas discharged by an engine, and a gas purifying housing which is provided with the gas purifying bodies therein, the exhaust gas purification device is structured such that a support bracket which supports the gas purifying housing is provided, a bolt hole is formed in the support bracket, an insertion guide is formed in the support bracket, and an attaching bolt is engaged with and disengaged from the bolt hole via the insertion guide.
US08926725B2 V-shaped filter with serviceable frames and cartridges
A V-shaped filter includes a V-shaped carrier frame, first and second cartridge frames movably mounted to the carrier frame, and first and second filter element cartridges removably and replaceably mounted to the first and second cartridge frames, respectively. The first and second cartridge frames are movable to an inserted position in the V-shaped carrier frame providing an installed condition with the first and second cartridge frames forming a V-shape, and are movable to an extended position extending beyond the V-shaped carrier frame and providing a replacement-service condition.
US08926721B2 Process for reformation of hydrogen-containing fluids in a cyclic flow reactor
The invention discloses an apparatus and process for the reformation of hydrogen containing fluids to hydrogen and other constituents, more particularly, the reformation of hydrocarbons or mixtures of hydrocarbons in a cyclic flow inert porous media reactor for the production of hydrogen and other constituents. In an alternate embodiment, the apparatus and process can be used for the reformation of hydrogen sulfide to produce hydrogen and sulfur.The cyclic flow reactor comprises a reaction chamber filled with a porous media matrix containing an unconstrained reaction zone located in any portion of the reactor chamber. This reactor system employs valves to canalize the reactant mixture and product mixture during flow cycling channeling the reactant mixture through the porous media matrix, and reacting the reactant mixture. In another embodiment, the reactor system may further comprise at least one aperture along the axial length of the reactor casing to enable mounting of an external energy source and/or at least one heat exchanger to provide a source of heat transfer to the inlet pipe and outlet pipe as well as the reactant mixture and product mixtures.
US08926719B2 Method and apparatus for generating hydrogen from metal
A hydrogen generator including a reactor chamber having a feedstock inlet and an inlet seal positioned at the feedstock inlet. At least one pair of feed rollers is positioned to draw a feedstock through the inlet seal and into the reactor chamber. At least one pair of distressing rollers is positioned in line with the feed rollers to produce stress in the feedstock. Steam is provided to the reactor chamber through a steam inlet and hydrogen is collected from a hydrogen outlet.
US08926708B2 Stem with pressfit porous element
An implant assembly comprises a stem and an augment. The augment includes a porous outer region which is integrally formed onto a solid inner region. The augment further includes, solid posts integrally formed on the solid inner region and extend through the porous outer region to the outer surface of the augment. The posts are integrally formed with and surrounded by the porous region and are designed to allow assembly of the augment to the stem without damaging the structure of the porous region. A method of attaching the augment is described, wherein a tool is designed to grip to posts of the augment and apply loads through these posts during assembly.
US08926706B2 Patient-adapted and improved articular implants, designs and related guide tools
Methods and devices are disclosed relating improved articular models, implant components, and related guide tools and procedures. In addition, methods and devices are disclosed relating articular models, implant components, and/or related guide tools and procedures that include one or more features derived from patient-data, for example, images of the patient's joint. The data can be used to create a model for analyzing a patient's joint and to devise and evaluate a course of corrective action. The data also can be used to create patient-adapted implant components and related tools and procedures.
US08926703B2 Spinal fusion implant with bone screws and a bone screw lock
An interbody spinal fusion implant made of a material other than bone adapted for placement across an intervertebral space formed across the height of a disc space between two adjacent vertebral bodies. The implant has a leading end that is curved to form a portion of a circle from side to side, sides that are at least in part straight, and a trailing end with a bone screw receiving hole for receiving at least one bone screw to engage the vertebral bodies.
US08926701B2 Allograft intervertebral implant and method of manufacturing the same
The present invention is directed to an allograft intervertebral implant sized and configured for insertion between adjacent vertebral bodies in a spinal fusion surgery. The implant is preferably manufactured from two or more pieces of allograft bone joined together by a joint, more preferably a dovetail joint. The dovetail joint being sized and configured to substantially follow the exterior shape or surface of the intervertebral implant.
US08926699B2 Composite bone graft kit
A composite bone graft which comprises an allograft bone component; a synthetic bone substitute, wherein the synthetic bone substitute is in contact with the allograft bone component. The composite is arranged in a core/outer layer structure.
US08926698B2 Moldable back breast form
A breast prosthesis for wearing against a chest of a user includes a bag, a first silicone rubber and a silicone agglomerate putty. The bag includes at least three films that are sealed together around a periphery so as to define at least a front chamber and a back chamber. The first silicone rubber is disposed in the front chamber and is cured in an outer shape of a breast. The silicone agglomerate putty is disposed in the back chamber and is configured as a shear thinning fluid that conforms in shape to surface features of the chest of the user when placed against the chest of the user.
US08926696B2 Adjustable annuloplasty devices and adjustment mechanisms therefor
Apparatus is provided including an implant structure (22, 122, 1122), a rotatable structure (2900) coupled to the implant structure (22, 122, 1122) in a vicinity of a first portion thereof, and a flexible member (30). At least a first portion of the 5 flexible member (30) is disposed in contact with the rotatable structure (2900), and at least one end portion of the flexible member (30) is not disposed in contact with the rotatable structure (30). In response to rotation of the rotatable structure (2900) in a first direction thereof, successive portions of the flexible member (30) contact the rotatable structure (2900) to pull the at least one end portion of the flexible member 0 (30) toward the first portion of the implant structure (22, 122, 1122), and responsively to draw the first and second portions of the implant structure (22, 122, 1122) toward each other. Other applications are also described.
US08926694B2 Dual valve prosthesis for transcatheter valve implantation
A dual valve prosthesis having first and second prosthetic valve sections is disclosed. The first prosthetic valve section includes a stent structure with a first prosthetic valve secured therein and the second prosthetic valve section includes an annular frame with a second prosthetic valve secured therein. When the dual valve prosthesis is in an expanded configuration, the annular frame extends from the stent structure such that the first and second prosthetic valves are laterally offset from each other. In a method in accordance herewith, the first and second prosthetic valve sections include prosthetic aortic and mitral valves, respectively, and the dual heart valve prosthesis is configured to replace both the native aortic and mitral valves of the heart in a single transcatheter heart valve implantation procedure.
US08926692B2 Transcatheter prosthetic heart valve delivery device with partial deployment and release features and methods
A delivery device for percutaneously deploying a stented prosthetic heart valve, including a delivery sheath, an inner shaft, and a spindle. The inner shaft is slidably disposed within a lumen of the delivery sheath. The spindle is attached to the shaft and includes a hub defining at least one longitudinal slot sized to slidably receive a post of the stented valve. An outer surface of the hub forms a curved proximal segment. The device provides a loaded state in which the delivery sheath retains the stented valve over the inner shaft and coupled to the spindle via the slot. In a deployed state, the distal end of the delivery sheath is withdrawn from the prosthesis to permit the stented valve to release from the slot, sliding along the curved outer surface of the hub.
US08926683B2 Stent delivery systems and methods
Apparatus, systems, and methods are provided for deploying an implantable device, such as a stent, within a lumen of a body of a patient. The delivery device may include an inner member and an outer sheath surrounding a distal portion of the inner member and configured to retain the implantable device sheathed near the distal end of the outer sheath until deployment. The outer sheath is slidably moveable relative to the inner member such that proximal movement of the outer sheath relative to the inner member deploys the implantable device. A trigger assembly of the delivery device can include an internal connector coupled to the outer sheath, a plurality of triggers, and a floater coupling two of the triggers. The triggers are serially retracted to deploy the stent. A panchor secures the stent against proximal and distal movement relative to the inner member during deployment.
US08926680B2 Aneurysm neck bridging processes with revascularization systems methods and products thereby
Devices, methods and systems facilitate and enable vessel wall treatment, particularly at the neck of an aneurysm. A tethered cage-like structure functions in conjunction with supplemental therapies such as a vaso-occlusive coil delivering microcatheter system and/or pharmaceutical delivery, among other things, by stabilizing vessel walls and providing tethered cage-like therapeutic support for treating aneurysms, temporarily or on an implantable basis.
US08926677B2 Interstitial energy treatment probe holders
An interstitial laser energy treatment apparatus having co-acting movable probe holders which facilitate positioning of a laser probe and thermal probe in different positions relative to a tissue mass such as the tumor to be treated and relative to each other to facilitate treating tissue masses based on the exact position, size and shape of the tissue mass.
US08926676B2 Systems and methods for applying signals, including contralesional signals, to neural populations
Systems and methods for applying signals, including contralesional electromagnetic signals, to neural populations, are disclosed. A particular method can be directed to treating a patient having a subject neural population in a first (e.g., ipsilesional) hemisphere of the brain, with the subject neural population having, or previously having, a functionality capable of being improved. The method can include directing an application of electromagnetic signals at least proximate to a target neural population at a second (e.g., contralesional) hemisphere of the brain to at least constrain a functionality of the target neural population, which has transcallosal communication with the first hemisphere.
US08926675B2 Contoured bone plate
A bone plate attachable to a bone for internal fixation. The bone plate has an upper surface and an opposite bone-contacting surface and includes a plurality of threaded through-holes for bone fasteners. The bone plate can include through-holes for passing sutures, and also suture-clearance recesses formed on the bone-contacting surface. Each suture-clearance recess is defined proximate to at least one of the suture holes for providing suturing clearance for a suturing instrument, such as a curved suturing needle.
US08926674B2 Fixation system for bones with a sensor and telemetry system
Fixation system for bones with a connection support, at least one bone screw that can be inserted into a through hole of the connection support and a sensor and telemetry system, wherein the sensor and telemetry system is arranged on a separate plate, which can be connected with the connection support.
US08926673B2 Vertebral arthrodesis equipment
This equipment comprises at least one anchoring assembly including two antagonistic hooks connected to each other through a rod, a first of these hooks having a body crossed by a hole for letting through the rod and being able to be connected to connection means with which the anchoring assembly may be connected to another part of the equipment; said body has an aperture laid out substantially perpendicularly to the axis of said hole, communicating with this hole, and the anchoring assembly has a tightening member which may be engaged into this aperture until it abuts against the rod engaged in the hole, and tightened in order to immobilize this rod in this hole. Said tightening member is directly connected to a part belonging to said connection means, which allows the mounting of the latter on the body of said first hook.
US08926670B2 Polyaxial bone screw assembly
A polyaxial bone screw assembly includes a shank body having an upper head portion with a mating segment and a first partial spherical surface, a retainer structure being mateable with the mating segment of the upper head portion, the retainer structure having a second partial spherical surface such that when mated, the first and second partial spherical surfaces form a spherical ball member, a receiver defining an open channel and having a base with a seating surface partially defining a cavity with a shaped wall, the open channel communicating with the cavity, the cavity communicating with an exterior of the base through an opening sized and shaped to receive the shank upper head portion therethrough, and a bushing sized and shaped to fit within open channel and cavity and lock in recesses on interior of receiver.
US08926667B2 Connector
A surgical implant device that controls the relative movement between a first bone or tissue portion and a second bone or tissue portion. The device has a first connector member connected for movement with the first bone or tissue portion and a second connector member connected for movement with the second bone or tissue portion. A biasing member pivotally connects the first connector member to the second connector member and resists the relative rotation between the first connector member and the second connector member.
US08926665B2 Cortical, anti-migration, facet dowel for fusion of facet joints in the spine and devices for setting the same in place
A novel allograft is provided for insertion into a prepared site between adjacent spinal facets. The allograft or facet dowel is typically comprised of three portions, a partially spherical body defining a spherical segment, a nose portion, and a tail portion, all aligned along a longitudinal axis. In addition, a set of instruments is provided for the excavation of an allograft placement site between the two facets. The set of instruments includes a T-spade drill which will, in conjunction with a normal drill, excavate a site for the emplacement of the allograft. A novel method of using the instruments and the allograft is also provided.
US08926664B1 Laminoplasty fixaction devices
Devices and methods for treating degenerative conditions of the spine or for alleviating pain or discomfort associated with the spinal column are disclosed. In particular, laminoplasty fixation devices and methods are disclosed. Also disclosed, is a vertebral implant comprising a first bone engaging portion configured for securing to a first cut portion of a vertebra and a second bone engaging portion configured for securing to a second cut portion of the vertebra. A body portion is provided for associating the first and second bone engaging portions at a preselected spacing from each other, wherein the implant is adjustable to select said spacing.
US08926662B2 Tissue graft anchoring
A fixation device includes a member defining at least two openings, and a suture tied to the member by passing the suture through the at least two openings in the member to form two suture loops through which ends of the suture pass. The two suture loops are interconnected. A method of securing a tissue graft includes providing the fixation member, attaching the suture to a tissue graft, and adjusting the length of the suture between the fixation member and the tissue graft by pulling the suture.
US08926660B2 Systems and methods of anchoring surgical wires, catheters, and other medical objects
The present disclosure generally provides systems and methods of anchoring surgical wires, catheters, leads, and other medical objects in an effective, efficient, and cost-sensitive manner. In one embodiment, the present disclosure could include a system to secure a medical object. The system could include a body having a first inner arm, a second inner arm, and a first outer arm. The first inner arm and the first outer arm could include a pronged structure. The system could also include a crossbar having a bore to receive a screw. The crossbar could be disposed between opposing surfaces of the first inner arm and the second inner arm and could be coupled to sliding grooves disposed along the opposing surfaces. When the screw is in an engaged position relative to the crossbar, the pronged structure could be configured to secure the medical object.
US08926659B2 Barbed suture created having barbs defined by variable-angle cut
A barbed suture is disclosed having barbs defined by a variable-angle cut surface. A cutting bed supports the suture during cutting. A cutting device is moved through the suture thread along a selected path. The angle of the cutting device is changed during cutting so that there is a corresponding change in the angle of the cut surface which defines each barb. A cutting arm is articulated to allow change of the angle of the cutting device. The change in the angle of the cutting device is used to control the shape and depth of cut of the barbs.
US08926657B2 System and method for transapical access and closure
Embodiments are described for creating and closing tissue access ports, such as transapical access ports, which involve placement of an introducer across the subject tissue structure, and deployment of a controllable port closure device assembly configured to remain in place with a ratcheting mechanism, and to hold the tissue surrounding the previous access port location closed against a sealing disc with proximal and distal strut assemblies, after the introducer has been removed.
US08926655B2 Method and system for sealing percutaneous punctures
A puncture closure device operable to seal closed a vessel puncture in a vessel. The puncture closure device includes a delivery member insertable through a tissue tract to the vessel puncture, a sealing material, and an expandable member. The sealing material is deliverable through the delivery member to the vessel puncture and configured to seal closed the vessel puncture from outside the vessel. The expandable member is positionable within the vessel through a vessel access distinct from the vessel puncture and is operable to temporarily seal closed the vessel puncture from within the vessel to restrict passage of the sealing material into the vessel.
US08926651B2 Self-locking tourniquet and automated timer
Tourniquet assemblies are provided including a pressure applicator adapted to be secured around a limb and a tensioning mechanism for applying a working tension to the pressure applicator. The tensioning mechanism may include a platform, a clip and a tensioning member. The tensioning mechanism may be configured to apply the working tension via rotation of the tensioning member, and the clip may be configured to receive, and at least temporarily inhibit rotation of, the tensioning member. A tension indicator may also be provided including a base configured to attach to a tourniquet strap, a platform configured to move relative to the base when subjected to a tourniquet working pressure, and one or more tactile or visual indicators configured to provide a variable tactile or visual indicator based on the tourniquet working pressure.
US08926645B2 Disposable lancing device
A disposable lancing device including: a lancet housed in a housing and urged by a spring member such that a puncture member provided at a distal end of the lancet is adapted to extend out from the housing so as to carry out a puncturing operation; a locking ring disposed within the housing such that the lancet is allowed to displace in an extension direction through the locking ring; a locking protrusion provided to the lancet and adapted to be engaged by the locking ring so as to hold the lancet in a puncture-ready position located deep in the housing with the spring member being compressed; and an operating member adapted to carry out the puncturing operation by rotating the locking ring so as to disengage the locking protrusion from the locking ring and displace the lancet in the extension direction by means of the spring member.
US08926644B2 Lancing device having saddle-shaped tip
A tip (41) for use with a lancing device (11). A wall extends upwardly from a base and forms a substantially saddle-shaped distal surface for interfacing with a patient's skin. An opening (43) extends entirely through the tip. The tip (41) is movably received by a pressure sleeve assembly. The pressure sleeve assembly includes a housing (37) and a pressure sleeve movable between first and second positions. A spring (35) is connected between the housing (37) and the pressure sleeve. A lancet (21) is rigidly fixed to the housing (37) and is covered when the pressure sleeve is in the first position and exposed through the substantially saddle-shaped distal surface (42) of the tip (41) when the pressure sleeve is in the second position. The substantially saddleshaped distal surface (42) gathers the patient's skin toward the center of the tip to facilitate expressing blood from a lanced site.
US08926639B2 Apparatus and methods for tissue closure
Apparatus and methods are provided for treating a tissue opening, for example a trocar opening used in a minimally invasive surgical procedure. In a tissue closure device, a finger guard or shield can be used, handle or holding area or areas can be used, and positioning indicators can be used. A resiliently flexible target material can also be used for reliably holding a suture during the procedure. Introducers can be used having a suture holder, an alignment indicator and insertion limits.
US08926634B2 Apparatus and methods for manipulating and securing tissue
Apparatus and methods for manipulating and securing tissue are described herein. In creating tissue folds within the body of a patient, a tissue manipulation assembly may generally have an elongate tubular member, an engagement member slidably disposed through the tubular member and a distal end adapted to engage tissue via a helical member, tissue stabilizing members positioned at the tubular member distal end which are adapted to stabilize tissue therebetween, and a delivery tube pivotable about the tissue stabilizer. The stabilizing members can be adapted to become angled relative to a longitudinal axis of the elongate tubular member. Moreover, one or all the articulation controls and functions can be integrated into a singular handle assembly connectable to the tissue manipulation assembly via a rigid or flexible tubular body.
US08926630B2 Device and method for fragmenting and removing concretions from body ducts and cavities
A medical device and method for breaking a concretion in a body into smaller pieces and removing the pieces from the body are described. The device comprises a dilator sheath, a lithotripsy probe, a tubular member, and a retrieval basket. The dilator sheath adapted to penetrate into a passage of the body to reach the location where the concretion is located. The lithotripsy probe is configured for shattering the concretion into smaller pieces. The tubular member is mounted within the dilator sheath adapted to permit the lithotripsy probe to be inserted into the tubular member. The retrieval basket is coupled to the tubular member, and configured for entrapping the concretion and the smaller pieces for their extraction from the body. The retrieval basket comprises a structure constituted by a plurality of filaments extending from a basket proximal end towards a basket distal end, and then returning to the proximal end after forming a plurality of filament loops in the basket distal portion, and a plurality of filament strands at the basket proximal portion.
US08926628B2 Multi-action device for inserting an intraocular lens into an eye
A device for inserting an intraocular lens (IOL) into an eye includes a tubular body member with an inner surface and a plunger with an gripping device that is receivable within the body member. The gripping device includes a locking member and is configured such that when urged longitudinally in a distal direction, the gripping device is movable in the distal direction within the body member. However, when urged longitudinally in a proximal direction, the gripping device is prevented from moving in the proximal direction by the locking member engaging with the inner surface of the body member. As such, inadvertent movement of the plunger in the proximal direction caused by pulling back on the plunger is substantially prevented. If proximal movement of the plunger is desired, then the plunger may include handle that is operatively coupled to the gripping device such rotation of the handle causes the handle to move longitudinally in the body member. Accordingly, the plunger may be advanced or moved distally by longitudinally pushing the handle and/or by rotating the handle.
US08926625B2 Surgical device
The invention relates to a surgical device, the device comprising a probe part and means to generate a Shockwave in the probes sufficient to separate, adjust of attach two or more, parts when the probe is applied to one of the part in vivo, the arrangement being such as to allow the application of a Shockwave that is regulated in amplitude and repeatable.
US08926623B2 System and method for forming porous bone filling material
A method for treating a vertebral bone comprises providing a gaseous substance and providing a flowable and settable bone filling material. The method further comprises introducing the gaseous substance into the bone filling material to form a porous bone augmentation material and inserting a material delivery device into the vertebral bone. The method further comprises injecting the porous bone augmentation material from the material delivery device and into the vertebral bone.
US08926622B2 Bone delivery systems including holding and filling devices and methods
A delivery system comprising a biodegradable single or multi compartment covering is provided. The covering can be a mesh bag including a pre-attached detachable holding member surrounding the opening of at least one compartment and a pre-attached removable filling member configured to fit within the opening of the at least one compartment. The opening of the bag can include a closing member. The pre-attached detachable holding member can be a collar including finger grips and is used to hold the bag in one position while filling it. In some embodiments, the pre-attached detachable filling member can be a funnel for loading the mesh bag with bone graft material. Once the covering is filled, the holding member and filling member can be removed and the covering is closed with a closing member such as a drawstring. A method of treatment utilizing the delivery system is also provided.
US08926621B2 Surgical instrument for acetabular cup implantation
A surgical instrument for acetabular cup implantation includes an acetabular cup, a shell body and a drive shaft. The drive shaft includes a drive rod and a handle bar. The handle bar engages the pivot for angular displacement having forward position and backward position. In the forward position the drive rod rotates the acetabular cup forward, and in the backward position the drive rod shifts backward resulting in the acetabular cup engaged the extension portion. Accordingly, the operator rotates the handle bar to control the acetabular cup inserting into the position of acetabulum. The rotation of the handle bar results in the gripping or releasing of the acetabular cup or insert from the invention. Thus the invention provides a clear and ergonomic instrument for medical personnel concerning the operation of acetabular cup implantation.
US08926619B2 Method of surgically preparing a tibia for implantation of a prosthetic component
A method of surgically preparing a tibia for implantation of a tibial prosthetic component is disclosed.
US08926615B2 System and method for retrograde procedure
A system and method may be used for accessing an articular surface and for preparing an implant site on the articular surface. The method may include locating a portion of the articular. An access passage may be drilled towards the articular surface though bone behind the articular surface. An implant site may be excised in the articular surface relative to an axis defined by the access passage.
US08926614B2 Medical electric drill
A medical electric drill includes a drilling head, a microprocessor, a pressure sensor unit, a torque sensor unit and a gravity sensor unit. The drilling head is for drilling a bone. The microprocessor is signally connected to the drilling head for calculating a displacement of the drill. The pressure sensor unit is for detecting a pressure change and provides a pressure change signal to the microprocessor. The torque sensor unit is for detecting a torque change and provides a torque change signal to the microprocessor. The gravity sensor unit is for detecting an acceleration variation of the drilling head and provides an acceleration voltage signal to the microprocessor. The microprocessor determines a work period of drilling the bone according to the pressure change signal and the torque change signal, and then the microprocessor calculates the displacement of the drilling head by using the acceleration voltage signal during the work period.
US08926612B2 Arthrodesis apparatus and method
An apparatus to promote bone fusion between portions of bone tissue comprises a bone engagement member and a flexible retention member. The bone engagement member comprises (a) an extramedullary bone contacting main body with a first surface defining a hole in the main body and (b) an intramedullary bone engaging projection extending from the main body. The projection engages the intramedullary portions of at least one the portions of bone tissue. The projection includes a second surface that defines a retention passage in the projection. The retention passage is spaced away from the hole and oriented transversely relative to the hole. The flexible retention member is configured and dimensioned to extend through the retention passage and into the hole to help retain the projection in intramedullary engagement with the at least one of the portions of bone tissue.
US08926611B2 Angular lag implant for intramedullary nails
An orthopedic assembly for stabilizing a fractured bone. The orthopedic assembly includes a support structure and an anchor. The anchor includes a first portion and a second portion moveably coupled to the first portion to adjust an angular orientation of the anchor relative to the femur.
US08926608B2 Bipolar medical instrument
A bipolar medical instrument has a shaft and two jaw parts arranged at the distal end thereof. An axially movable force transmission element is disposed with the shaft and is surrounded by an isolating element. The isolating element is connected to at least one of the two jaw parts in an articulated manner. The two jaw parts are electrically isolated from one another and each provides an electrode to which high frequency current can be applied. A first electrical supply line is formed along the shaft via an electrically conductive first contact element to one of the two jaw parts. A second electrical supply line is formed along the axially movable force transmission element via an electrically conductive second contact element to the other of the two jaw parts. The first contact element is fixed at the isolating element surrounding the distal end area of the force transmission element.
US08926607B2 Electrosurgical instrument employing multiple positive temperature coefficient electrodes
An electrosurgical surgical instrument can comprise a handle and an end effector, wherein the end effector can comprise first and second jaws which can be opened and closed in order to capture tissue therebetween. In various embodiments, the first and second jaws can comprise one or more electrodes configured to apply a voltage across the tissue, wherein one or both of the first and second jaws can include a plurality of electrodes each comprised of a positive temperature coefficient material having a different switching temperature. The electrical resistances of the electrodes can increase significantly once the temperature of the electrodes exceed their switching temperatures and, owing to the increased electrical resistance, the flow of current through the electrodes can be reduced and/or prevented. In various circumstances, the different switching temperatures of the electrodes can allow some of the electrodes to switch off before the other electrodes.
US08926604B2 Estimation and mapping of ablation volume
Tissue ablation systems and methods are provided, wherein a cardiac catheter incorporates a pressure detector for sensing a mechanical force against the distal tip when engaging an ablation site. Responsively to the pressure detector, a controller computes an ablation volume according to relationships between the contact pressure against the site, the power output of an ablator, and the energy application time. A monitor displays a map of the heart which includes a visual indication of the computed ablation volume. The monitor may dynamically display the progress of the ablation by varying the visual indication.
US08926600B2 Operator-controlled scanning laser procedure designed for large-area epithelium removal
Systems and methods for removing an epithelial layer disposed over a stromal layer in a cornea irradiate a region of the epithelial layer with a pulsed beam of ablative radiation. The ablative radiation is scanned to vary the location of the beam within the region in accordance with a pulse sequence. The pulse sequence is arranged to enhance optical feedback based on a tissue fluorescence of the epithelial layer. The penetration of the epithelial layer is detected in response to the optical feedback. The use of scanning with the pulse sequence arranged to enhance optical feedback allows large areas of the epithelium to be ablated such penetration of the epithelial layer can be detected.
US08926599B2 Medical instrument
A medical instrument in the form of an endoscopic shank instrument includes an actuation element which is axially displaceable in a shank. Two lever arms are pivotably articulated in a manner distanced to one another and are positioned at a proximal side of the shank. The lever arms form part of a grip part. The lever arms are coupled in movement to the actuation element and are coupled directly to one another.
US08926595B2 Devices, formulations, and methods for delivery of multiple beneficial agents
The present invention relates to osmotic delivery devices, formulations, and methods for delivery of two or more beneficial agents. In one aspect, the present invention provides osmotic delivery devices useful for substantially concurrent administration of two or more beneficial agents. In another aspect, the present invention provides beneficial agent formulations for use in the osmotic delivery devices. The formulations include formulations wherein beneficial agents are soluble in the vehicle, suspension formulations comprising particle formulations of one or more beneficial agent, and combinations thereof. Further, methods for treatment of a variety of diseases or conditions using two or more beneficial agents are disclosed, wherein the methods are preferably practiced using the osmotic delivery devices and/or formulations of the invention.
US08926593B2 Wound support for use in vacuum therapy of wounds
A wound support (50) for use in the vacuum therapy of wounds, can be disposed in its intended use in a wound space underneath a vacuum dressing (6) sealing the wound space with respect to the atmosphere in an essentially vacuum-tight manner, wherein the wound space can communicate with a suction tube (10) to which a vacuum can be applied through an opening (20) in the vacuum dressing (6). The wound support (50) comprises a flexibly compliant foamed material and has a through-hole (54) that extends in the direction of the wound depth, which is used to insert or pass through a wound-side end section (44) of a fluid feed tube (40). A sleeve (56) is disposed in the through-hole (54) into which this end section (44) can be inserted.