Document Document Title
US08907327B2 Display device and organic light-emitting display device having connection part for electronically connecting different levels of conductors
A display device and organic light-emitting display device, the display device including a substrate; a first line on the substrate; a first pad electrically connected to the first line, the first pad being on a same layer as the first line; a second line on another layer different from the layer on which the first line is formed, an insulation layer being interposed between the first line and the second line; a second pad on a same layer as the first pad; and a connection part electrically connecting the second line and the second pad.
US08907326B2 Organic light-emitting display device and thin film deposition apparatus for manufacturing the same
A thin film deposition apparatus that can be used to manufacture large substrates on a mass scale and that improves manufacturing yield, and an organic light-emitting display device manufactured using the thin film deposition apparatus. The organic light-emitting display device includes: a substrate including a plurality of sub-deposition areas arranged parallel to each other; at least one thin film transistor formed on the substrate, the at least one thin film transistor comprising a semiconductor active layer, a gate electrode insulated from the semiconductor active layer, and source and drain electrodes contacting the semiconductor active layer; a plurality of pixel electrodes formed on the thin film transistor; a plurality of organic layers formed on each of the pixel electrodes; and a counter electrode formed on the organic layers, wherein the plurality of organic layers lie in each of the sub-deposition areas and have a larger shadow zone the further a distance from a center of the corresponding deposition area.
US08907324B2 Organic light emitting display device having solar cell polarizing film
An organic light emitting display not only display images but also generates power by employing a dye-sensitized solar cell as a polarizing film of the organic light emitting display. The organic light emitting display includes: a substrate; an Organic Light Emitting Diode (OLED) including an anode arranged on an upper surface of the substrate, an organic thin film arranged on an upper surface of the anode, and a cathode arranged on an upper surface of the organic thin film; and a solar cell layer arranged on an upper surface of the cathode.
US08907321B2 Nitride based quantum well light-emitting devices having improved current injection efficiency
A III-nitride based device provides improved current injection efficiency by reducing thermionic carrier escape at high current density. The device includes a quantum well active layer and a pair of multi-layer barrier layers arranged symmetrically about the active layer. Each multi-layer barrier layer includes an inner layer abutting the active layer; and an outer layer abutting the inner layer. The inner barrier layer has a bandgap greater than that of the outer barrier layer. Both the inner and the outer barrier layer have bandgaps greater than that of the active layer. InGaN may be employed in the active layer, AlInN, AlInGaN or AlGaN may be employed in the inner barrier layer, and GaN may be employed in the outer barrier layer. Preferably, the inner layer is thin relative to the other layers. In one embodiment the inner barrier and active layers are 15 Å and 24 Å thick, respectively.
US08907320B2 Light-emitting diode for emitting ultraviolet light
An ultraviolet (UV) light-emitting diode including an n-type semiconductor layer, an active layer disposed on the n-type semiconductor layer, a p-type semiconductor layer disposed on the active layer and formed of p-type AlGaN, and a p-type graphene layer disposed on the p-type semiconductor layer and formed of graphene doped with a p-type dopant. The UV light-emitting diode has improved light emission efficiency by lowering contact resistance with the p-type semiconductor layer and maximizing UV transmittance.
US08907318B2 Resistance change memory
A resistance change memory includes a first conductive line extending in a first direction, a second conductive line extending in a second direction which is crossed to the first direction, a cell unit including a memory element and a rectifying element connected in series between the first and second conductive lines, and a control circuit which is connected to both of the first and second conductive lines. The control circuit controls a voltage to change a resistance of the memory element between first and second values reversibly. The rectifying element is a diode including an anode layer, a cathode layer and an insulating layer therebetween.
US08907316B2 Memory cell access device having a pn-junction with polycrystalline and single crystal semiconductor regions
A memory device includes a driver comprising a pn-junction in the form of a multilayer stack including a first doped semiconductor region having a first conductivity type, and a second doped semiconductor region having a second conductivity type opposite the first conductivity type, the first and second doped semiconductors defining a pn-junction therebetween, in which the first doped semiconductor region is formed in a single-crystalline semiconductor, and the second doped semiconductor region includes a polycrystalline semiconductor. Also, a method for making a memory device includes forming a first doped semiconductor region of a first conductivity type in a single-crystal semiconductor, such as on a semiconductor wafer; and forming a second doped polycrystalline semiconductor region of a second conductivity type opposite the first conductivity type, defining a pn-junction between the first and second regions.
US08907311B2 Charged particle radiation therapy
A system includes a patient support and an outer gantry on which an accelerator is mounted to enable the accelerator to move through a range of positions around a patient on the patient support. The accelerator is configured to produce a proton or ion beam having an energy level sufficient to reach a target in the patient. An inner gantry includes a robotic arm capable of directing an aperture for directing the proton or ion beam towards the target.
US08907307B2 Apparatus and method for maskless patterned implantation
A method of implanting a workpiece in an ion implantation system. The method may include providing an extraction plate adjacent to a plasma chamber containing a plasma, such that the extraction plate extracts ions from the plasma through at least one aperture that provides an ion beam having ions distributed over a range of an angles of incidence on the workpiece. The method may include scanning the workpiece with respect to the extraction plate and varying a power level of the plasma during the scanning from a first power level to a second power level, wherein at a surface of the workpiece, a first beam width at a first power level is greater than a second beam width at a second power level.
US08907304B2 Ultraviolet autonomous trolley for sanitizing aircraft
A mobile body is configured to travel over a surface inside an aircraft cabin. A source of UV radiation is mounted to the mobile body and configured to direct UV radiation to the surface at a predetermined dosage. At least two articulated arms are mounted to the mobile body, and UV lamps mounted respectively on the arms. The mobile body is a trolley or cart for negotiating an aircraft aisle.
US08907299B2 Film member, film target for laser-driven ion acceleration, and manufacturing methods thereof
The present disclosure provides a method of manufacturing film member for laser-driven ion acceleration, a film target, and a method of manufacturing the same, so that only the film member exists at a laser focusing point on the film target, allowing repeated ion acceleration from the film member by focusing high power laser beams thereon. The method includes preparing a film member solution containing a film material to be used for laser-driven ion acceleration; forming a film member on a base substrate by using the film member solution; and separating the film member from the base substrate by dipping the base substrate having the film member formed thereon into a film parting solvent.
US08907290B2 Methods and systems for gain calibration of gamma ray detectors
A method for gain calibration of a gamma ray detector includes measuring signals generated by one or more light sensors of a gamma ray detector, generating one or more derived curves using the measured signals as a function of bias voltage and identifying a transition point in the one or more derived curves. The method also includes determining a breakdown voltage of the one or more light sensors using the identified transition point and setting a bias of the one or more light sensors based on the determined breakdown voltage.
US08907288B2 Digitally scanned multi-cell electro-optic sensor
A digitally scanned multi-cell EO sensor comprises a low-resolution multi-cell imaging detector. An array of optical focusing elements decomposes the sensor's FOV into at least four sub-fields. A sub-field directing array and focusing optic direct the optical radiation onto the imaging detector. In a first tilt mode, the optical radiation from the sub-fields is directed into at least four spatially separated sub-regions that each map to a different detector cell. A high-resolution spatial light modulator (SLM) digitally scans the FOV to select different portions of the FOV to map onto the different detector cells to time demultiplex spatially overlapping portions of the FOV onto each detector cell to stitch together a sub-image of a selected area of the FOV up to the native resolution of the SLM.
US08907281B2 System and method for controlling charge-up in an electron beam apparatus
The present invention provides means and corresponding embodiments to control charge-up in an electron beam apparatus, which can eliminate the positive charges soon after being generated on the sample surface within a frame cycle of imaging scanning. The means are to let some or all of secondary electrons emitted from the sample surface return back to neutralize positive charges built up thereon so as to reach a charge balance within a limited time period. The embodiments use control electrodes to generate retarding fields to reflect some of secondary electrons with low kinetic energies back to the sample surface.
US08907278B2 Charged particle beam applied apparatus, and irradiation method
Provided is a charged particle beam applied apparatus for observing a sample, provided with: a beam-forming section that forms a plurality of charged particle beams on a sample; an energy control unit that controls the incident energy of the plurality of charged particle beams that are irradiated onto the sample; a beam current control unit that controls the beam current of the plurality of charged particle beams that are irradiated onto the sample; and a beam arrangement control unit that controls the arrangement in which the plurality of charged particle beams is irradiated onto the sample. The beam-forming section includes a beam splitting electrode, a lens array upper electrode, a lens array middle electrode, a lens array lower electrode and a movable stage, and functions as the beam current control unit or the beam arrangement control unit through selection, by the movable stage, of a plurality of aperture pattern sets.
US08907276B2 Measuring the populations in each hyperfine ground state of alkali atoms in a vapor cell while limiting the contribution of the background vapor
A method for measuring the population of atoms in a vapor cell comprises collecting a sample of atoms, applying radio frequency (RF) spectroscopy to the sample such that a first portion of the atoms are in an upper ground state and a second portion of the atoms are in a lower ground state, and applying light to the sample to produce a first fluorescence such that all atoms are left in the lower ground state. The method further comprises measuring a population of the atoms in the upper ground state based on the first fluorescence, applying an RF pulse to the sample to transfer the atoms in the lower ground state to the upper ground state, and applying light to the sample after the RF pulse is applied to produce a second fluorescence. A population of all the atoms in the sample is then measured based on the second fluorescence.
US08907274B2 Quadrupole mass spectrometer
A quadrupole power source which applies a voltage to each electrode (2a-2d) of a quadrupole mass filter (2) receives inputs of an m/z-axis correction coefficient Mcomp1 and a V-voltage correction coefficient Vcomp1 in addition to a power supply controlling voltage Qcont according to the m/z of a target ion. Vcomp1 is a reciprocal of the ratio by which a frequency is changed, while Mcomp1 is the square of the ratio by which the frequency is changed. In a detection gain adjuster section (4C), a multiplier (421) multiplies an output Vdet′ of a V-voltage adjusting amplifier (405) by Vcomp1, whereby the radio-frequency voltage produced by a radio-frequency power supply section (4A) is maintained at the same level even when the set frequency of a signal generator (411) is changed in order to tune an LC resonance circuit.
US08907270B2 Method and apparatus for gain regulation in a gamma detector
Methods and systems to determine and regulate the gain of gamma-ray detectors in tools equipped with neutron sources are provided. Gain regulation may be based on the gamma ray background generated in the tool by interaction of neutrons with the nuclei of some elements constituting the tool structure. Some chemical elements that are used in construction of the tool's mechanical parts and structure result in characteristic gamma ray lines in a measured energy spectrum. These lines can be used to calibrate the energy scale of the response of the detector, without any added calibration radio isotopic source.
US08907265B2 Frequency selective electromagnetic detector
An apparatus, system, and method are disclosed for a frequency selective electromagnetic detector. In particular, the frequency selective electromagnetic detector includes a nanowire array constructed from a plurality of nanowires of different compositions. At least one nanoparticle-sized diameter thermoelectric junction is formed between the nanowires of different compositions. When a nanoparticle-sized diameter thermoelectric junction senses a photon, the nanoparticle-sized diameter thermoelectric junction emits an electrical pulse voltage that is proportional to an energy level of the sensed photon. In one or more embodiments, the frequency selective electromagnetic detector is a frequency selective optical detector that is used to sense photons having optical frequencies. In at least one embodiment, at least one of the nanowires in the nanowire array is manufactured from a compound material including Bismuth (Bi) and Tellurium (Te).
US08907264B2 Motion and simple gesture detection using multiple photodetector segments
An optoelectronics apparatus selectively drives a light source, and includes four electrically isolated photodetector (PD) segments that detect light that has reflected off an object. Each of the four PD segments produces a corresponding signal, referred to as signals A, B, C and D, indicative of the light detected by the respective PD segment. Circuitry is used to produce a first motion signal indicative of a sum of the signals A plus B minus a sum of the signals C plus D, i.e., the first motion signal is indicative of (A+B)−(C+D). Further circuitry produces a second motion signal indicative of (B+C)−(A+D). Additional circuitry produces a signal and/or data that is indicative of a direction and/or rate of motion of an object, in dependence on the first and second motion signals.
US08907257B2 Contactlessly chargeable heater
The present invention relates to a contactlessly chargeable heater. In one example, the contactlessly chargeable heater includes: an induction patch emitting magnetic field by means of current applied to an inner coil; and a heating body, receiving the magnetic field from the charging patch to perform a contactless charging operation, and including a conductive metal yarn for emitting heat via the power generated through the contactless charging operation. The conductive metal yarn is woven together using threads within the heating body.
US08907255B2 Method for deicing a power supply line for railway vehicles
This method for deicing a direct current power supply line for railway vehicles is provided for a line extending between at least a first and a second reversible substations able to supply an electrical current circulating on the electrical power supply line, the first substation being controlled in a current supply mode, to supply an electrical current to the electrical power supply line and the second substation being controlled in a current recovery mode, to recover the electrical current from the electrical power supply line and send it back on an electrical power supply network. The method comprises establishing a voltage difference between the output terminals of the first and second substations such that a current circulates on the electrical power supply line between the two substations and that the heat produced by the circulation of the current causes the deicing of the power supply line between the two substations.
US08907251B2 Personal thermal regulating device
A personal thermal regulating device (PTRD) typically includes a heat generating device, a power source, a switchable control operably coupled with each of the heat generating device and the power source, and a head retention device coupled with the heat generating device and configured to retain the heat generating device positioned centrally at and in thermally conductive contact with a user's forehead. The present invention affects a tangible warming of the extremities, particularly the hands and feet, extending retention of manual dexterity and peripheral comfort under cold conditions.
US08907250B2 Pane with heatable optically transparent sensor array
A pane having a heatable, optically transparent sensor array comprising at least: a) a pane, b) at least one optically transparent sensor array on the surface of the pane, c) at least one heatable film which is fitted to the optically transparent sensor array, comprising at least: c1) a support film, c2) a heatable coating, printed conductors, meshes and/or heating wires on the support film, d) at least one electrical contact-making means, which is fitted to the heatable coating and/or to the heating wires, and e) encapsulation, which is fitted to the optically transparent sensor array and to the heatable film, and a sensor which is fitted in the encapsulation.
US08907248B2 Aluminum deoxidizing welding wire
Provided is a welding method and electrodes (wires) with aluminum as a primary deoxidizer and a basic flux system for joining a workpieces with weld metal of comparable strengths and enhanced toughness. For instance, provided is a welding wire, comprising an aluminum content configured to act as a primary deoxidizer, and an overall composition configured to produce a weld deposit comprising a basic slag over a weld bead, wherein the aluminum content is configured to kill the oxygen in the weld pool, and wherein the oxygen comprises oxygen provided by a shielding gas or produced by heating of welding filler materials. Further provided is a welding method comprising arc welding a workpiece using an electrode having aluminum as a primary deoxidizer under a gas shield to produce a bead of weld deposit and a basic slag over the weld bead.
US08907246B2 Flux-cored wire for welding different materials, method for laser welding of different materials and method for MIG welding of different materials
There are provided a flux-cored wire for welding different materials, a method for laser welding of different materials and a method for MIG welding of different materials which can improve tensile shear strength of a welded joint portion and peeling strength of a welded portion interface in welding aluminum or an aluminum alloy material and a steel material. The flux-cored wire has a cylindrical sheath comprising an aluminum alloy which contains Si in an amount of 1.5 to 2.5% by mass and Zr in an amount of 0.05 to 0.25% by mass, with the remainder being aluminum and inevitable impurities, and a flux filling inside this sheath and containing cesium fluoride in an amount of 20 to 60% by mass, and the packing fraction of the flux being 5 to 20% by mass of the total mass of the wire.
US08907245B2 Apparatus for removal of specific seed tissue or structure for seed analysis
An apparatus for reducing resources for selecting seed to be produced in commercial quantities or for research is disclosed. Samples of seed which are candidates for selection are collected and given an identifier. Specific tissue or structure from candidate seed is removed. A test or analysis is performed on the candidate seed or the removed tissue or structure. Results of the test or analysis are recorded and correlated to the seed's identifier. The results are evaluated and a decision is made whether to select a candidate seed for commercial production or for research. Time, space, and labor associated with growing plants in an experimental plot or greenhouse and taking tissue samples from growing plants is saved.
US08907243B2 Maintenance system for wire transport system of wire discharge processing machine
The tension measuring unit that measures a physical amount corresponding to tension of a wire in a wire transport system, the fluctuation recording unit that records the physical amount measured by the tension measuring unit, the fluctuation analysis unit that obtains an average value, variation, and frequency analysis data of the recorded physical amount as an analysis result of the physical amount, the maintenance necessity determining unit that compares the analysis result with a reference value and determines whether maintenance is needed based on a comparison result and the display unit that displays a determination result are included, and it is made possible to accurately determine the time for maintenance for various components used in the wire transport system without using a measuring instrument.
US08907242B2 Machine for flash-butt welding of rails
A machine for the flash butt welding of rails is provided. The machine comprises electric contacts yokes having controlled drives and further comprise holes through which guide pins are passed.
US08907238B2 Push button, method for the production thereof, and medical manipulating part
A push button of a medical manipulating part comprising: a first, pot-shaped, shell-shaped or box-shaped housing piece, at least some sections of which contain conductive material, with an integrally molded switching spring and a continuous wall, a second housing piece, the shape of which mates with the wall of the first housing piece and is inserted therein in a hermetically sealed manner such that a hollow space is formed between the first and second housing pieces underneath the switching spring and at least one mating contact for the switching spring, said mating contact being hermetically sealed and electrically isolated relative to the first housing piece, being led through the second housing piece and extending into the hollow space underneath the switching spring.
US08907230B2 Solar photovoltaic junction box assembly
The invention discloses a solar photovoltaic junction box assembly having a housing having a housing body and a housing cover, a cable extending into the housing body and joined to the housing body, and an electrical connector disposed in the housing body and including at least a metal piece electrically connected to a solar cell and a terminal electrically connected to the cable, wherein a chamber for filling gel therein is formed between the terminal and the joint of the cable with the housing body. A part of the cable extending into the housing is fixed to and sealed in the housing by filling gel in the chamber, and first and second over-molded structures can further prevent the cable from being loosened relative to the housing of the junction box, and further prevent water from entering into the housing of the junction box.
US08907228B2 Circuit structure of electronic device and its manufacturing method
The present disclosure related to circuit structure of an electronic device, wherein the circuit structure comprises of a main line formed on a substrate; and at least an auxiliary line electrically connected to the main line to form a conductive return circuit used for a signal to pass through the auxiliary line when the main line is disconnected. Addition of the auxiliary line avoids any breaking of signal transmission due to partial disconnection of the main line. The present disclosure also relates to a method for manufacturing the circuit structure, wherein the method simplifies the manufacturing process and also reduces the rate of deformation or disconnection of lines.
US08907218B2 Cable and polymer composition
The invention relates to a cable having a conductor surrounded by at a least one polymer layer having a polymer composition of the invention which has a polymer component and optionally a carbon black (CB) component, to a production process of the cable and to a polymer composition of the invention which has a polymer component and optionally a carbon black (CB) component and which is for use in a cable layer.
US08907217B2 Compositions for riser and plenum cables
Materials for making cable jackets, particularly riser and plenum cables, are provided. The materials provide low flammability and allow the cable to meet UL 910 or NFPA 262 or UL 1666 specifications. The material contains PVC resin, a plasticizer, a metal oxide particle, and optionally a brominated phthalate. Preferably, the metal oxide particle is spherical amorphous silicon dioxide. More preferably, the spherical amorphous silicon dioxide has a mean particle size of about 100-200 nm and/or a BET surface area of about 10-30 m2/g. The metal oxide particle is also preferably metal oxide particle non-porous, non-ionic, and/or non-hydrated.
US08907215B2 Corrugated tube protector
A box-shape corrugated tube protector includes a side wall including an opening with a guide part at each both sides of the opening; a bottom wall including an insertion depression adapted to receive and support a corrugated tube, in communication with the opening; and a cover adapted to close the opening including a slide part slidably engaging with the guide part, and also including a projecting ridge and a rib inside, wherein the projecting ridge has an end face along a circumference of the corrugated tube, the rib has a projecting end face formed curved or sloped, continuous from the projecting ridge in a sliding direction of the cover, and the end face of the projecting ridge and the projecting end face of the rib smoothly intersects to each other.
US08907214B1 Stackable electrical box
A method and structure of a system of electrical boxes including differing patterns of interference structures, such as ribs and/or grooves, to prevent identical boxes from being nested but permit non-identical boxes from being nested for more space-efficient storage of electrical boxes.
US08907211B2 Power cable with twisted and untwisted wires to reduce ground loop voltages
An improved power cable having an untwisted ground wire and at least two current carrying wires twisted about one another. The at least two current carrying wires make up a group having a central axis located at the cross sectional rotation axis of the current carrying wires and at a fixed distance from a cross sectional center of the untwisted ground wire, and wherein the current carrying wire group central axis and a ground wire central axis helically rotate around a common axis.
US08907209B2 Photoelectric conversion element
Disclosed is a photoelectric conversion element which includes a semiconductor electrode, an opposite electrode, and an electrolyte layer held between the semiconductor electrode and the opposite electrode, and which is a photoelectric conversion element of high practical use using a redox couple which has high transparency and ease of enclosure and exhibits high performance compared to an iodine redox couple. An electrolyte layer includes a redox couple formed of compounds represented by General Formula (1) and Formula (2), and ionic liquid having bis(fluorosulfonyl)imide anion represented by Formula (3).
US08907208B2 Dye-sensitized solar cell including a collector
Disclosed is a dye-sensitized solar cell. The dye-sensitized solar cell includes a working electrode and a counter electrode configured to join the working electrode. The working electrode includes a photo electrode having a plurality of photo electrode cells coated on a transparent conductive substrate and arranged in linear rows and a collector having a plurality of collector cells coated on the transparent conductive substrate and arranged along perimeters of the photo electrode and between the photo electrode cells and a collector bottom portion integrally interconnecting the collector cells. The collector cells have a same length or the collector cells arranged along the perimeters have a different length from the collector cells arranged between the photo electrode cells to increase an active area of the photo electrode.
US08907203B2 Integrated thin-film solar battery
An integrated thin-film solar battery is disclosed. The integrated thin film solar battery includes a plurality of series connected solar cell strings with one or more power collecting electrodes electrically joined to the string. The thin-film photoelectric conversion elements have a first transparent electrode layer and a second transparent electrode layer sandwiching a photoelectric conversion layer. The string has an element separating groove and the first electrode layer has an extending section having one end that crosses the element separating groove and extends to a region of an adjacent element. At least a portion of the first electrode layer just below the power collecting electrodes and another portion of the first electrode layer are insulated and separated from each other by at least one of an electrode separating line and an insulating line.
US08907198B2 Electric stringed musical instrument standard electronic module
A standard electronic module for an electric stringed musical instrument is provided. The standard electronic module is mounted within the main body of the electric stringed musical instrument in a module cavity in the back of the electric stringed musical instrument. The standard electronic module comprises two printed circuit boards, a main printed circuit board and a connector circuit board, wherein the standard electronic module provides rapid exchange of the main printed circuit board without changing the wiring harness of the electric stringed musical instrument, which is directly connected to the connector printed circuit board.
US08907196B2 Method of sound analysis and associated sound synthesis
A sound analysis and associated sound synthesis method is provided. A first input sound signal is received and analyzed, to determine its corresponding impulse response representative of a timbre of the input sound signal. A second input sound signal is received and processed into a form which the corresponding impulse response is susceptible to being applied, wherein the processing includes generating a “pink noise” equivalent frequency spectrum of the second input sound signal. The impulse response is applied to the processed second input sound signal to generate an output signal, wherein the output sound signal includes at least timbral nuances of the first input sound signal.
US08907192B2 Waveform data generating apparatus and waveform data generating program
The waveform data generating apparatus has a waveform data generating circuit WP which inputs a digital signal formed of a plurality of bits which form a control signal for controlling an external apparatus, and generates waveform data indicative of a waveform of a control tone which corresponds to the input digital signal, is formed of tones corresponding to respective values of the bits of the input digital signal, and is formed of frequency components included in a certain high frequency band. The waveform data generating circuit WP has a basic waveform data extraction portion WP7 which extracts a part or a whole of the intermediate portion which is situated at an intermediate portion of the waveform data, and corresponds to the intermediate portion of the digital signal whose bit pattern coincides with a certain bit pattern as basic waveform data.
US08907190B2 Switch device and electronic musical instrument
The present invention includes a first rotating operation unit which is arranged in one end section of an instrument main body such that a portion thereof protrudes from the top surface of the instrument main body, and switch-operated by the protruding portion being rotated by the thumb of a left hand, and a second rotating operation unit which is arranged posterior to the first rotating operation unit such that a portion thereof is exposed on a side surface side of the end section, and switch-operated by the exposed portion being rotated by a finger other than the thumb. Accordingly, when the left hand is placed on the end section, the thumb is placed corresponding to the first rotating operation unit, and the other finger is placed corresponding to the second rotating operation unit, whereby these rotating operation units can be rotated separately by only the left hand.
US08907187B2 Stringed musical instrument with a guitar-banjo combination sound
A stringed musical instrument with a guitar-banjo combination sound is an apparatus that is designed to be played in the same manner as a typical guitar but is also designed to be more portable than a typical guitar. The apparatus includes a sound box coupled to a guitar neck, which allows a plurality of strings to tensioned and connected along the apparatus. The sound box is configured to produce the guitar-banjo combination sound. The sound box includes a stretched membrane, a pot chamber, a channel, and a sound chamber. The stretched membrane is perimetrically connected around the pot chamber and is used to create the banjo portion of the apparatus's sound. stretched membrane resonates the air within the pot chamber, whose sound waves travel through the channel in order to be modified by the sound chamber. A bridge is used to connect the plurality of strings to the stretched membrane.
US08907186B1 Maize inbred PH13JW
A novel maize variety designated PH13JW and seed, plants and plant parts thereof. Methods for producing a maize plant that comprise crossing maize variety PH13JW with another maize plant. Methods for producing a maize plant containing in its genetic material one or more traits introgressed into PH13JW through backcross conversion and/or transformation, and to the maize seed, plant and plant part produced thereby. Hybrid maize seed, plant or plant part produced by crossing the variety PH13JW or a locus conversion of PH13JW with another maize variety.
US08907185B2 Cotton variety ST 4288B2F
The cotton variety ST 4288B2F is disclosed. The invention relates to seeds, plants, plant cells, plant tissue, harvested products and cotton lint as well as to hybrid cotton plants and seeds obtained by repeatedly crossing plants of variety ST 4288B2F with other plants. The invention also relates to plants and varieties produced by the method of essential derivation from plants of ST 4288B2F and to plants of ST 4288B2F reproduced by vegetative methods, including but not limited to tissue culture of regenerable cells or tissue from ST 4288B2F.
US08907182B1 Soybean variety BG4272
A novel soybean variety, designated BG4272 is provided. Also provided are the seeds of soybean variety BG4272, cells from soybean variety BG4272, plants of soybean BG4272, and plant parts of soybean variety BG4272. Methods provided include producing a soybean plant by crossing soybean variety BG4272 with another soybean plant, methods for introgressing a transgenic trait, a mutant trait, and/or a native trait into soybean variety BG4272, methods for producing other soybean varieties or plant parts derived from soybean variety BG4272, and methods of characterizing soybean variety BG4272. Soybean seed, cells, plants, germplasm, breeding lines, varieties, and plant parts produced by these methods and/or derived from soybean variety BG4272 are further provided.
US08907180B2 Soybean variety A1037425
The invention relates to the soybean variety designated A1037425. Provided by the invention are the seeds, plants and derivatives of the soybean variety A1037425. Also provided by the invention are tissue cultures of the soybean variety A1037425 and the plants regenerated therefrom. Still further provided by the invention are methods for producing soybean plants by crossing the soybean variety A1037425 with itself or another soybean variety and plants produced by such methods.
US08907178B2 Soybean variety A1037405
The invention relates to the soybean variety designated A1037405. Provided by the invention are the seeds, plants and derivatives of the soybean variety A1037405. Also provided by the invention are tissue cultures of the soybean variety A1037405 and the plants regenerated therefrom. Still further provided by the invention are methods for producing soybean plants by crossing the soybean variety A1037405 with itself or another soybean variety and plants produced by such methods.
US08907176B2 Soybean variety A1037390
The invention relates to the soybean variety designated A1037390. Provided by the invention are the seeds, plants and derivatives of the soybean variety A1037390. Also provided by the invention are tissue cultures of the soybean variety A1037390 and the plants regenerated therefrom. Still further provided by the invention are methods for producing soybean plants by crossing the soybean variety A1037390 with itself or another soybean variety and plants produced by such methods.
US08907172B2 Soybean variety A1035361
The invention relates to the soybean variety designated A1035361. Provided by the invention are the seeds, plants and derivatives of the soybean variety A1035361. Also provided by the invention are tissue cultures of the soybean variety A1035361 and the plants regenerated therefrom. Still further provided by the invention are methods for producing soybean plants by crossing the soybean variety A1035361 with itself or another soybean variety and plants produced by such methods.
US08907169B2 Soybean variety A1037510
The invention relates to the soybean variety designated A1037510. Provided by the invention are the seeds, plants and derivatives of the soybean variety A1037510. Also provided by the invention are tissue cultures of the soybean variety A1037510 and the plants regenerated therefrom. Still further provided by the invention are methods for producing soybean plants by crossing the soybean variety A1037510 with itself or another soybean variety and plants produced by such methods.
US08907168B2 Soybean variety A1037490
The invention relates to the soybean variety designated A1037490. Provided by the invention are the seeds, plants and derivatives of the soybean variety A1037490. Also provided by the invention are tissue cultures of the soybean variety A1037490 and the plants regenerated therefrom. Still further provided by the invention are methods for producing soybean plants by crossing the soybean variety A1037490 with itself or another soybean variety and plants produced by such methods.
US08907164B2 Regulating nutrient allocation in plants
The invention provides coding and promoter sequences for a VS-1 and AP-2 gene, which affects the developmental process of senescence in plants. Vectors, transgenic plants, seeds, and host cells comprising heterologous VS-1 and AP-2 genes are also provided. Additionally provided are methods of altering nutrient allocation and composition in a plant using the VS-1 and AP-2 genes.
US08907163B2 Transgenic plants expressing galactosyltransferase and sialyl transferase
The invention relates to the field of glycoprotein processing in transgenic plants used as cost efficient and contamination safe factories for the production of recombinant biopharmaceutical proteins or pharmaceutical compositions comprising these. The invention provides a plant comprising functional mammalian β1,4-galactosyltransferase and mammalian sialyl transferase for producing complex N-linked glycans that are galactosylated and sialylated, said plant additionally comprising at least a second mammalian protein or functional fragment thereof that is normally not present in plants.
US08907159B1 Maize inbred PH24DM
A novel maize variety designated PH24DM and seed, plants and plant parts thereof. Methods for producing a maize plant that comprise crossing maize variety PH24DM with another maize plant. Methods for producing a maize plant containing in its genetic material one or more traits introgressed into PH24DM through backcross conversion and/or transformation, and to the maize seed, plant and plant part produced thereby. Hybrid maize seed, plant or plant part produced by crossing the variety PH24DM or a locus conversion of PH24DM with another maize variety.
US08907157B2 Methods for producing transgenic rodents having recombinant immunoglobulin loci
The invention provides methods for the production of transgenic animals comprising a recombinant Ig locus, as well as transgenic antibodies derived therefrom. The methods involve meganuclease cleavage-stimulated homologous recombination in mammalian embryos.
US08907156B2 Absorbent article having a multifunctional containment member
An absorbent article such as a diaper, training pant, and the like comprises a containment member that has a central zone and a barrier zone. The central zone has greater air flow according to the Air Permeability Test than the barrier zone. The bather zone a greater hydrohead according to the Hydrostatic Head Pressure Test than the central zone. The containment member may be used for absorbent core formation and may have portions configured to serve as barrier leg cuffs for the finished absorbent article.
US08907150B2 Biogenic fuel and method of making same
A method of producing from a biomass mesitylene-isopentane fuel is provided. A biomass may be fermented to form acetone. The acetone is converted in a catalytic reactor to mesitylene and mesityl oxide. The mesitylene is separated in a phase separator and the organic face containing mesityl oxide is sent to a dehydration reactor, then to a demethylation reactor, and finally to a hydrogenation reactor from which isopentane is recovered. This isopentane is then mixed with the mesitylene to form the final mesitylene-isopentane fuel. The catalytic reaction with acetone employs catalysts of either niobium, vanadium or tantalum.
US08907148B2 Process for the production of chlorinated propenes
Processes for the production of chlorinated propenes are provided. The present processes make use of a feedstock comprising 1,2,3-trichloropropane and chlorinates the 1,1,2,3-tetrachloropropane generated by the process prior to a dehydrochlorination step. Production of the less desirable pentachloropropane isomer, 1,1,2,3,3-pentachloropropane, is thus minimized. The present processes provide better reaction yield as compared to conventional processes that require dehydrochlorination of 1,1,2,3-tetrachloropropane prior to chlorinating the same. The present process can also generate anhydrous HCl as a byproduct that can be removed from the process and used as a feedstock for other processes, while limiting the production of waste water, thus providing further time and cost savings.
US08907146B2 Process for the preparation of 1-chloro-3,3,3-trifluoropropene using a phase transfer catalyst
Disclosed is a process in which the fluorination of an organic reactant comprising 1,1,1,3,3-pentachloropropane (240fa) with anhydrous HF is conducted in the presence of an effective amount of a phase-transfer catalyst which facilitates the reaction between these incompatible reaction components to produce 1-chloro-3,3,3-trifluoro-propene (1233zd). Other organic reactant materials include 1,1,3,3-tetrachloropropene (HCO-1230za), 1,3,3,3-tetrachloropropene (HCO-1230zd), and various mixtures with or without 240fa.
US08907145B2 Aerosol propellants comprising unsaturated fluorocarbons
Disclosed herein are propellants comprising fluorocarbons and/or hydrofluorocarbons. Also disclosed are sprayable compositions comprising the propellants.
US08907134B2 Perfuming ingredient of the galbanum family
The present invention relates to 1-(5-ethyl-5-methyl-1-cyclohexen-1-yl)-4-penten-1-one and its use as perfuming ingredient.
US08907133B2 Electrolyte compositions and electrochemical double layer capacitors formed there from
The invention generally encompasses phosphonium ionic liquids, salts, compositions and their use in many applications, including but not limited to: as electrolytes in electronic devices such as memory devices including static, permanent and dynamic random access memory, as electrolytes in energy storage devices such as batteries, electrochemical double layer capacitors (EDLCs) or supercapacitors or ultracapacitors, electrolytic capacitors, as electrolytes in dye-sensitized solar cells (DSSCs), as electrolytes in fuel cells, as a heat transfer medium, among other applications. In particular, the invention generally relates to phosphonium ionic liquids, salts, compositions, wherein the compositions exhibit superior combination of thermodynamic stability, low volatility, wide liquidus range, ionic conductivity, and electrochemical stability. The invention further encompasses methods of making such phosphonium ionic liquids, salts, compositions, operational devices and systems comprising the same.
US08907132B2 Process for preparing (R)-2-acetamido-N-benzyl-3-methoxy-propionamide
Processes for preparing and purifying (R)-2-acetamido-N-benzyl-3-methoxy-propionamide of formula-1 and intermediates thereof are provided.
US08907129B2 Process for preparing decanecarboxylic acids
The invention relates to a process for preparing a mixture of isomeric decane-carboxylic acids, which comprises the following steps: a) hydroformylation of a hydrocarbon mixture containing linear C4-olefins using a rhodium-containing catalyst system; b) aldol condensation of a mixture of aliphatic C5-aldehydes obtained from step a); c) selective hydrogenation of the mixture of unsaturated C10-aldehydes from step b) to aliphatic C10-aldehydes; d) uncatalysed oxidation of the mixture of aliphatic C10-aldehydes from step c) to give a mixture having a proportion of at least 70% by mass of 2-propylheptanoic acid, based on the total content of isomeric decanecarboxylic acids.
US08907126B2 Tyrosine derivative and method for producing tyrosine derivative
The objective of the present invention is to provide a tyrosine derivative which is useful as a melatonin MT1 receptor antagonist, and a method for producing a specific tyrosine derivative with high yield by efficiently introducing an iodine atom at the para position of the phenolic hydroxy group in the benzene ring of tyrosine with good regioselectivity. The tyrosine derivative of the present invention is characterized in being represented by the following formula (I): wherein R1 is a protective group of the amino group and the like; R2 is a protective group of the carboxy group and the like; R3 is a hydrogen atom and the like; R4 is a halogen atom and the like; A is —(CH2)l—[Z(CH2)m]n—; X is a leaving group.
US08907122B2 Method of preparing photoacid generating monomer
A method of preparing a monomer comprises reacting a sultone of the formula (I): wherein each R is independently F, C1-10 alkyl, fluoro-substituted C1-10 alkyl, C1-10 cycloalkyl, or fluoro-substituted C1-10 cycloalkyl, provided that at least one R is F; n is an integer of from 0 to 10, and m is an integer of 1 to 4+2n, with a nucleophile having a polymerizable group. Monomers, including a photoacid-generating monomer, may be prepared by this method.
US08907116B2 Process for removing an alkanol impurity from a dialkyl carbonate stream
The invention relates to a process for removing an alkanol impurity from a stream containing a dialkyl carbonate and the alkanol impurity, comprising contacting the stream with an aryl group containing ester and a catalyst to effect reaction of the alkanol impurity with the aryl group containing ester.
US08907106B2 Process for the resolution of enantiomers by preferential evaporative crystallization
A process for the resolution of two enantiomers which involves inducing the preferential crystallization of one enantiomer by adjusting the composition of a suspension or solution including a racemic mixture of the two enantiomers and a solvent, by evaporation of the latter.
US08907105B1 1,2,3-triazolium ionic liquids
The present invention relates to compositions of matter that are ionic liquids, the compositions comprising substituted 1,2,3-triazolium cations combined with any anion. Compositions of the invention should be useful in the separation of gases and, perhaps, as catalysts for many reactions.
US08907103B2 Glucagon antagonists
Provided herein are compounds, including enantiomerically pure forms thereof, and pharmaceutically acceptable salts or co-crystals and prodrugs thereof which have glucagon receptor antagonist or inverse agonist activity. Further, provided herein are pharmaceutical compositions comprising the same as well as methods of treating, preventing, delaying the time to onset or reducing the risk for the development or progression of a disease or condition for which one or more glucagon receptor antagonist is indicated, including Type I and II diabetes, insulin resistance and hyperglycemia. Moreover, provided herein are methods of making or manufacturing compounds disclosed herein, including enantiomerically pure forms thereof, and pharmaceutically acceptable salts or Co-crystals and prodrugs thereof. Formula I
US08907101B2 Sulfonamide derivatives
The present invention relates to compounds of the formula and pharmaceutically acceptable salts, solvates or tautomers thereof, to processes for the preparation of, intermediates used in the preparation of, and compositions containing such compounds, and the uses of such compounds, in particular for the treatment of pain.
US08907095B2 Bicyclic heterocycle derivatives and their use as modulators of the activity of GPR119
The present invention relates to Bicyclic Heterocycle Derivatives, compositions comprising a Bicyclic Heterocycle Derivative, and methods of using the Bicyclic Heterocycle Derivatives for treating or preventing obesity, diabetes, a metabolic disorder, a cardiovascular disease or a disorder related to the activity of GPR119 in a patient.
US08907091B2 Processes and intermediates for preparing fused heterocyclic kinase inhibitors
This invention relates to processes and intermediates for manufacturing fused heterocyclic-type kinase inhibitor compounds, such as thienopyridine-based compounds, and to processes and intermediates for preparing intermediates that are useful in the manufacture of fused heterocyclic-type kinase inhibitor compounds, such as thienopyridine-based compounds, particularly at an industrial level.
US08907088B2 Methods of making cyclic, N-amino functional triamines
The present invention provides strategies for making cyclic triamines. Reactant media including certain precursors and/or certain types of catalysts can be converted into cyclic triamines with improved conversion and selectivity. The strategies can be incorporated into reactions that involve transamination schemes and/or reductive amination schemes. In the case of transamination, for instance, using transamination to cause ring closure of higher amines in the presence of a suitable catalyst leads to desired cyclic triamines with notable conversion and yield. In the case of reductive amination, reacting suitable polyfunctional precursors in the presence of a suitable catalyst also yields cyclic triamines via ring closure with notable selectivity and conversion. Both transamination and reductive amination methodologies can be practiced under much milder temperatures than are used when solely acid catalysts are used. Preferred embodiments can produce reaction mixtures that are generally free of salt by-products.
US08907086B2 Fused bicyclic heterocycles useful as dipeptidyl peptidase-IV inhibitors
The present invention is directed to novel bicyclic heterocycles of structural formula (I) which are inhibitors of the dipeptidyl peptidase-IV enzyme and which are useful in the treatment or prevention of diseases in which the dipeptidyl peptidase-IV enzyme is involved, such as diabetes and particularly Type 2 diabetes. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of such diseases in which the dipeptidyl peptidase-IV enzyme is involved.
US08907085B2 Hydrate of sulfonylurea compound, process for producing the same and suspension formulation containing the same
The present invention relates to a hydrate of sulfonylurea compound represented by formula (I): having herbicidal activity, a process for producing the same, a suspension formulation containing the same, and the like.
US08907080B2 Process for imparting water solubility or water dispersibility to hydrophobic cluster compound
Provided is a complex comprising a hydrophobic cluster compound and a β-1,3-1,6-D-glucan having a degree of branching (a ratio of β-1,6 linkages to β-1,3 linkages) of 50 to 100%.
US08907079B2 Crosslinking reagents, macromolecules, therapeutic conjugates, and synthetic methods thereof
The invention provides novel chemical entities based on sugar alcohols. These new chemical entities are biocompatible and biodegradable. The molecules can be made in a single and pure form. The molecular weights of these molecules range from small (<1000 Da) to large (1000-120,000 Da). The sugar alcohol-based molecules can have functional groups throughout the molecule for crosslinking compounds, such as the preparation of antibody-drug conjugates, or to facilitate the delivery of therapeutic proteins, peptides, siRNA, and chemotherapeutic drugs. Also provided are new conjugate entities prepared through sugar alcohol molecules. Methods of synthesizing sugar alcohol-based molecules and conjugates are also within the scope of the invention.
US08907077B2 siRNA targeting TIE-2
Efficient sequence specific gene silencing is possible through the use of siRNA technology. By selecting particular siRNAs by rational design, one can maximize the generation of an effective gene silencing reagent, as well as methods for silencing genes. Methods, compositions, and kits generated through rational design of siRNAs are disclosed.
US08907074B2 Laticiferous tissue-specific SRPP promoter from Hevea brasiliensis and uses thereof
A laticiferous tissue-specific SRPP (small rubber particle-associated protein) promoter derived from Hevea brasiliensis, consists of nucleotide sequence of SEQ ID NO: 1. A recombinant plant expression vector includes the promoter. A plant is transformed with the recombinant plant expression vector and seed of the transformed plant is obtained. A method for laticiferous tissue-specific expression of a foreign gene in a transformed plant includes performing recombination of a foreign gene into the recombinant plant expression vector. The transformed plant produced by the method shows laticiferous tissue-specific expression of a foreign gene.
US08907073B2 Nucleic acids encoding FOXD3 promoter and methods to isolate FOXD3 expressing cells
DNA enhancer sequences are provided for use in constructs to identify early stage embryonic cells. The enhancer sequences can be used in parallel with short-hairpin RNA in a vector construct for endogenously regulated gene knockdowns. The disclosed enhancer sequences can be used to isolate a selected population of early stage embryonic cells.
US08907069B2 Complex of bi-specific antibody and digoxigenin conjugated to a therapeutic or diagnostic agent
The present invention relates to complexes of a) bi-specific antibodies and antibody fragments against a target protein and b) a digoxigenin conjugated to a therapeutic or diagnostic agent, methods for their production, their use as a delivery platform for therapeutic or diagnostic agents, pharmaceutical compositions containing said antibodies, and uses thereof.
US08907065B2 Polypeptides that modulate the interaction between cells of the immune system
The present invention relates to amino acid sequences that block the interaction between (a target on) an antigen presenting cell (APC) and (a target on) a T-cell. More particularly, the present invention relates to amino acid sequences that are directed against (as defined herein) a target on an APC (also referred to herein as “APC target”) or a target on a T-cell (also referred to herein as “T-cell target”). The invention further relates to compounds or constructs, and in particular proteins and polypeptides, that comprise or essentially consist of one or more such amino acid sequences.
US08907062B2 Method of producing and purifying soluble recombinant COQ5 protein and soluble recombinant COQ5 protein thereof
The present invention relates to a producing and purifying method of soluble recombinant coenzyme Q5 homolog (COQ5) protein, which is expressed in soluble form by Escherichia coli (E. coli), under native conditions. The method is characterized by pre-treating bacterial lysate with low concentration of ionic detergent, such as sodium dodecyl sulfate (SDS), before purification; and the purifying method is performed under native condition without using urea to avoid the problems of requiring lengthy processes to remove urea in purified protein solution or re-aggregation and precipitation of protein after removal of urea.
US08907061B2 Nanolipoprotein particles and related methods and systems for protein capture, solubilization, and/or purification
Provided herein are methods and systems for assembling, solubilizing and/or purifying a membrane associated protein in a nanolipoprotein particle, which comprise a temperature transition cycle performed in presence of a detergent, wherein during the temperature transition cycle the nanolipoprotein components are brought to a temperature above and below the gel to liquid crystalling transition temperature of the membrane forming lipid of the nanolipoprotein particle.
US08907060B2 Mutated Pseudomonas exotoxins with reduced antigenicity
The invention provides mutated Pseudomonas exotoxins (PE) that have reduced immunogenicity compared to PEs containing the native sequence. The PEs of the invention have one or more individual mutations of positions of the native sequence of PE that reduce antibody binding to one or more PE epitopes. Nucleic acids encoding the mutated PEs, chimeric molecules comprising them, compositions comprising the chimeric molecules and methods of using them, are also provided.
US08907059B2 Phosphopeptide enrichment of compositions by fractionation on ceramic hydroxyapatite
Phosphorylated peptides are extracted from digests of biological liquids and other peptide mixtures by fractionation on ceramic hydroxyapatite. The ceramic hydroxyapatite is readily usable in a centrifuge, allowing for rapid fractionations of a large number of small volume samples, and accordingly high throughput.
US08907058B2 PSMA binding ligand-linker conjugates and methods for using
Described herein are prostate specific membrane antigen (PSMA) binding conjugates that are useful for delivering therapeutic, diagnostic and imaging agents. Also described herein are pharmaceutical composition containing them and methods of using the conjugates and compositions. Also described are processes for manufacture of the conjugates and the compositions containing them.
US08907054B2 Dpy-30 binding peptides
Disclosed are compositions and methods for modulating Dpy-30 binding activity. The compositions may include peptides or peptidomimetics thereof that are related to radial spoke protein 3 (RSP3) or absent, small, homeotic discs 2-like protein (Ash2L) and that bind to Dumpy-30 protein (Dpy-30).
US08907051B2 Process for forming an aramid copolymer
The invention concerns processes for forming a polymer comprising residues of 2-(4-amino phenyl)-5(6) amino benzimidazole (DAPBI), paraphenylene diamine (PPD), and terephthaloyl dichloride, comprising the steps of: (a) forming a solution of oligomers having amine end groups from two moles of DAPBI and one mole of terephthaloyl dichloride in a solvent system comprising an organic solvent and an inorganic salt; (b) adding PPD to the solution of oligomers; and (c) adding additional terephthaloyl dichloride to form a polymer.
US08907049B2 Thermoset resin compositions with increased toughness
A block copolymer (M) suitable for toughening a thermoset resin (R). The block copolymer (M) has at least one block derived from a thermoplastic aromatic polymer (A) which exhibits a glass transition temperature (Tg) of at least about 150° C., and at least one block derived from a low Tg polymer (B) wherein: (i) the low Tg polymer (B) exhibits a Tg in the range of from about −130° C. to about +40° C.; (ii) the aromatic polymer (A) is soluble in the uncured thermoset resin precursor(s) (P) of the thermoset resin (R), and (i) the low Tg polymer (B) is insoluble in the uncured thermoset resin precursor (P).
US08907045B2 Biocompatible adhesive polymers
Block co-polymers including a hydrophilic block and a hydrophobic poly(amino acid) block which further includes dihydroxyphenyl moieties are provided, as well as methods of making and using the same. Such block copolymers may be used to prepare biocompatible adhesives which display good adhesives properties in aqueous environments, including in in vivo applications.
US08907044B2 Polycarbonate resin and transparent film comprising the same
The polycarbonate resin of the present invention comprises a structural unit derived from a dihydroxy compound represented by a specific formula (1), a structural unit derived from a dihydroxy compound represented by a specific formula (2), and a structural unit derived from a dihydroxy compound represented by any one of specific formulae (3) to (6), wherein the content of structural units derived from dihydroxy compounds represented by the specific formulae (3) to (6) is within a specific range based on the total of structural units derived from dihydroxy compounds in the polycarbonate resin.
US08907043B2 Preparation and uses of polyarylates
The present invention is directed to polyarylates comprising repeating units having the structure: as well as their preparation and use as cell growth substrates.
US08907042B2 Polyetherimides, methods of manufacture, and articles formed therefrom
A polyetherimide manufactured by reaction of an alkali metal salt of a dihydroxy aromatic compound of the formula MO—Z—OM wherein M is an alkali metal salt and Z is an aromatic C6-24 monocyclic or polycyclic moiety optionally substituted with 1 to 6 C1-8 alkyl groups, 1 to 8 halogen atoms, or a combination thereof, with a bis(halophthalimide) composition comprising, based on the weight of the bis(halophthalimide) composition, from more than 45 to less than 75 weight percent of a 3,3′-bis(halophthalimide) of the formula less than 10 weight percent of a 3,4′-bis(halophthalimide) of the formula and from more than 45 to less than 75 weight percent of a (4,4′-bis(halophthalimide) of the formula
US08907039B2 Method for preparing (hydroxymethyl)polysiloxanes
Lateral hydroxymethyl-substituted organopolysiloxanol are prepared by reacting a silanol-stopped organosiloxane with a hydrolyzable methyleneoxy-group-containing organosilicon compound.
US08907038B2 Typical metal containing polysiloxane composition, process for its production, and its uses
A material suitable for sealing an LED element or for a gas barrier layer for a resin component, and an LED device, an FPD device and a semiconductor device using it. A process for producing a polymer composition, which includes mixing and reacting as component (A), an unsaturated group-containing siloxane compound of the following formula (1): wherein the siloxane structure is a chain or cyclic structure, as component (B), a siloxane compound having a structure of the following formula (2) wherein hydrogen is directly bonded to silicon, wherein the siloxane structure is a chain or cyclic structure, as component (C), at least one member selected from the group consisting of organic metal compounds of Group 1, 2, 12, 13 and 14 metals of the periodic table, and as component (D), a metal catalyst of Group 8, 9 or 10 metal of the periodic table.
US08907036B2 Self-adhesive silicone compositions which can be crosslinked to form elastomers
Self-adhesive crosslinkable silicone compositions may be transparent and prepared without conventional adhesion promoters, and contain (1) an organopolysiloxane having a minimum of two aliphatically unsaturated carbon-carbon bond-containing groups, (2) a pendant Si—H functional organopolysiloxane having at least 3 Si—H groups and a minimum of 0.7 weight percent of Si-bonded hydrogen, and (3) a linear organopolysiloxane bearing terminal Si—H groups, wherein the mol ratio of silicon-bonded hydrogen in (2) to that in [(2) and (3)] is from 0.05 to 1.
US08907035B2 Polyethylene Copolymers
A multimodal ethylene copolymer having the following properties: i) density comprised in the range from 0.880 to 0.955 g/cm3; ii) total comonomer content ranging from 6% to 25% by weight; iii) content of 1-butene derived units ranging from 0 to 2% by weight; iv) Mw/Mn comprised from 4 to 20; v) intrinsic viscosity (decalin at 135° C. as determined according to EN ISO 1628-312003) comprised between 1.0 and 4.0 dL/g; said multimodal ethylene copolymer comprises from 10% to 80% by weight of a first polyethylene component and being detected at the Crystaf® apparatus at a temperature higher than 75° C. and from 90% to 20% by weight of a second polyethylene component being a copolymer being detected at a Crystaf® apparatus at a temperature lower than 75° C.; wherein said multimodal ethylene copolymer being fractionated into 12 fractions by means of the Holtrup analysis, the fractions containing more than 2% by weight of the total amount of material meet the following relationship: Cf/HDPE>−0.0075HDPE+0.58; wherein Cf is the amount (% wt) of comonomer of formula CH2═CHT in the copolymer of the fraction and HDPE is the amount (% wt) of the homopolymer component present in the fraction.
US08907033B2 Polymers, compositions and methods of use for foams, laundry detergents, shower rinses and coagulants
A polymeric material including units capable of having a cationic charge at a pH of from about 4 to about 12; provided that the polymeric material has an average cationic charge density from about 2.75 or less units per 100 daltons molecular weight at a pH of from about 4 to about 12. The polymeric material is a suds enhancer and a suds volume extender for hand dishwashing compositions and personal care products such as soaps, shaving cream foam, foaming shaving gel, foam depiliatories and shampoos. The polymers are also effective as a soil release agent in fabric cleaning compositions. The polymers are also useful in agrochemical foam, fire-fighting foam, hard surface cleaner foam, and coagulant for titanium dioxide in paper making.
US08907032B2 Salalen ligands and organometallic complexes
Use of homogeneous catalytic systems which include as a pre-catalyst a complex of a Group IV metal and a salalen ligand in the polymerization of alpha-olefins, is disclosed. The alpha-olefin polymers obtained are characterized by controlled levels of tacticity. Also disclosed are novel salalen ligands and novel complexes thereof with Group IV metals.
US08907026B2 Crosslinkable saccharide-siloxane compositions, and networks, coatings and articles formed therefrom
The invention provides a cross-linkable composition comprising a saccharide-siloxane copolymer according to a specified structural formula, a crosslinking agent, and, optionally, solvent. Cross-linked polymeric networks, cured coatings, and articles of manufacture formed from the inventive compositions are also provided, as well as processes and methods of manufacturing the inventive cross-linkable compositions and applications thereof.
US08907022B2 Method to form an aqueous dispersion of an ionomer
Disclosed is a method for forming an aqueous dispersion of an ionomer composition comprising mixing a solid ionomer composition with water heated to a temperature from about 80 to about 90° C., the solid ionomer composition comprising an ethylene acid copolymer comprising about 18 to about 30 weight % of copolymerized units of acrylic acid or methacrylic acid, based on the total weight of the parent acid copolymer, the acid copolymer having a melt flow rate from about 200 to about 1000 g/10 min., wherein about 50% to about 70% of the total carboxylic acid groups of the copolymer are neutralized to carboxylic acid salts comprising sodium cations.
US08907020B2 Golf ball
An object of the present invention is to provide a golf ball having high resilience. The present invention provides a golf ball having a constituting member, wherein at least a part of the constituting member is formed from a rubber composition containing (a) a base rubber, (b) a co-crosslinking agent, (c) a crosslinking initiator, and (d) an organic sulfur compound, the organic sulfur compound being derivatives of thiophenols and disulfide with a strong electron withdrawing substituent.
US08907019B2 Polypropylene composition with high elasticity and transparency
A propylene polymer composition comprising (percent by weight referring to the sum of A+B): A) 60%-90% of a crystalline propylene copolymer containing from 1.0% to 5.0% of ethylene derived units; B) 10%-40% of a copolymer of propylene with from 18% to 32% of ethylene derived units, said propylene polymer composition having a melt flow rate value according to ISO 1133 (230° C., 2.16 kg) of from 1.0 to 2.0 g/10 min.
US08907017B2 Water-absorbing polymer structure having improved permeability and absorption under pressure
The present invention relates to a process for the preparation of water-absorbing polymer structures, comprising the following process steps: I) providing an untreated, water-absorbing polymer structure; and II) bringing the untreated, water-absorbing polymer structure into contact with a salt comprising a divalent or higher-valent cation of a metal and at least one organic base as anion. The invention relates also to the water-absorbing polymer structures obtainable by that process, to water-absorbing polymer structures, to a composite comprising a water-absorbing polymer structure and a substrate, to a process for the preparation of a composite, to the composite obtainable by that process, to chemical products, such as foams, molded articles and fibers comprising water-absorbing polymer structures or a composite, to the use of water-absorbing polymer structures or of a composite in chemical products and to the use of a salt in the treatment of the surface of water-absorbing polymer structures.
US08907015B2 Copolymer of pyrene and pyrrole and method of producing the copolymer
The present application provides a copolymer including one or more units of pyrene and one or more units of pyrrole. The present application also provides a method of producing a copolymer, including incubating pyrene monomer and pyrrole monomer with an oxidant in the presence of a reaction solvent. Uses of the copolymers are also provided.
US08907013B2 Polycarbonate resin composition and molded product using the same
Disclosed are a polycarbonate resin composition that includes (A) about 5 wt % to about 89 wt % of a polycarbonate resin; (B) about 10 wt % to about 94 wt % of a polycarbonate-polysiloxane copolymer; and (C) about 1 wt % to about 70 wt % of a modified acrylic-based copolymer, and a molded product made using the polycarbonate thermoplastic resin composition.
US08907010B2 Fast setting sheet fed offset inks with non-aqueous dispersion polymers
A non aqueous dispersion is disclosed containing: a shell polymer; a core polymer, and a continuous phase solvent, wherein said shell polymer is soluble and said core polymer is insoluble in the continuous solvent. Also disclosed is a method for improving the setting properties of a sheet fed offset ink by adding to the ink the above non aqueous dispersion.
US08907006B1 Filler-containing liquid silicone rubber base of improved color and reproducibility
Liquid silicone rubber base polymer compositions having improved color are prepared by reaction of fumed silica reinforcing filler with a silazane, and without drying the silazane-treated filler, an aliphatically unsaturated silicone is added, heated to above 80° C., and then further aliphatically unsaturated silicone is added. The compositions have improved whiteness and color reproducibility.
US08907004B2 Sulfonic acid monomer based compositions
The present invention relates to a composition which comprises a stable aqueous dispersion of discrete polymer particles and a water-soluble dispersant adsorbed onto the surfaces of pigment particles, wherein the polymer particles comprise structural units of a sulfonic acid monomer or a salt thereof. The present invention addresses a need in the art by providing a way to improve the hiding efficiency of compositions containing pigment such as TiO2 and associative rheology modifiers.
US08906991B2 Low/zero VOC glycol ether-esters and use as clean-up solvents and paint thinners
This invention relates to a clean-up solvent and paint thinner for solvent-borne resins and coatings selected from compositions of Formula (I) wherein R1 is a C1-C10 alkyl group, phenyl or benzyl, R2 is either hydrogen or methyl, R3 is a carbon chain including 4-6 carbon atoms, and n=2-4; of Formula (II) wherein R1 and R4 are, independently, C1-C10 alkyl groups, phenyl or benzyl, R2 is either hydrogen or methyl, R3 is a carbon chain including 0-4 carbon atoms, and n=1-4; and mixtures thereof. The invention also relates to a solvent-borne composition including a solvent-borne polymer and the low and zero VOC composition of the invention; and a method for cleaning or thinning a solvent-borne composition.
US08906990B2 Surface treatment agent for galvanized steel sheets, galvanized steel sheets and production methods thereof
Disclosed is a surface treatment agent for galvanized steel sheets, which comprises epoxy-containing silane derivates, alkyl-containing silane derivates, alkoxy silane derivates and one or more selected from the group consisting of a cationic polymer aqueous dispersion, a non-ionic polymer aqueous dispersion and a water-soluble polymer. Also disclosed is a method for producing it, which comprises mixing each component uniformly for 0.5 to 8 hours at 5 to 70° C. Further provided are galvanized steel sheets coated with the surface treatment agent on the surface and a production method thereof. The surface treatment agent for galvanized steel sheets has excellent corrosion resistance, alkali resistance, solvent resistance, recoating property, high temperature resistance and electrical conductivity.
US08906986B2 Additive for building product mixtures containing flow agents
Claimed is a cationic copolymer and also its use as an admixture agent for building product systems, especially based on calcium sulfate. The copolymers of the invention effectuate accelerated setting behavior in clay-containing as well as non-clay-containing gypsums and they enable uncurtailed water reduction performance by dispersant agents used at the same time with the copolymers. The clay fractions in the gypsum system are masked by the cationic copolymer, and so the building product mixture exhibits properties of a building product mixture not containing clay. The copolymers are used as a formulation and also together with retarders.
US08906982B2 Coating with improved hiding compositions prepared therewith, and processes for the preparation thereof
A coating containing pigment particles and a polymer matrix is provided. The coating contains pigment particles that have a scattering coefficient with a linear or quasi-linear relationship to the pigment volume concentration of those pigment particles. The coating has improved hiding and is useful as a protective coating or an aesthetic coating on an underlying substrate. Also provided are compositions useful for preparing the coating, including covalently bonded composite particles and aqueous dispersions containing composite particles. The composite particles each contain a pigment particle with a plurality of polymer particles attached by adsorption on the outer surface of the pigment particle or by covalent bonding to the pigment particle through a coupling agent. Methods to prepare the composite particles and coating compositions containing the composite particles are also provided.
US08906980B2 Water-soluble polymer composition, composition for forming plaster layer of skin patch, and skin patch
The present invention relates to a water-soluble polymer composition which comprises a water-soluble poly(meth)acrylic polymer and a gelation rate retarding agent, and a composition for forming a plaster layer of a skin patch which is obtainable by adding a polyvalent metal compound to the water-soluble polymer composition. When a polyvalent metal compound is added, the aforesaid water-soluble polymer composition shows an appropriate induction period before the start of the hardening of the gel. When the water-soluble polymer composition is used for forming a plaster layer of a skin patch, therefore, additive ingredients can be uniformly mixed and the procedure for coating to a support can be facilitated.
US08906975B1 Conventional flexible polyurethane foam using MDI
A conventional flexible polyurethane foam, made using methylene diphenyl diisocyanate (MDI), having a bulk foam density in the range of 2.5 pounds per cubic foot or lower and having a foam hardness or IFD in the range of 10 to 90 lb/50 in2. The present invention is also directed to the method for the making thereof.
US08906974B2 Method for producing polyurethane foam
A method for producing polyurethane foams by reacting at least one organic isocyanate moiety, at least one polyol, a blowing agent consisting of halogen-containing (fluorine-containing) olefins and at least a siloxane of Formula I b, c and d are defined herein, as well as compositions made by said method are described.
US08906971B2 Catalysts and process for liquid hydrocarbon fuel production
The present invention provides a novel process and system in which a mixture of carbon monoxide and hydrogen synthesis gas, or syngas, is converted into hydrocarbon mixtures composed of high quality gasoline components, aromatic compounds, and lower molecular weight gaseous olefins in one reactor or step. The invention utilizes a novel molybdenum-zeolite catalyst in high pressure hydrogen for conversion, as well as a novel rhenium-zeolite catalyst in place of the molybdenum-zeolite catalyst, and provides for use of the novel catalysts in the process and system of the invention.
US08906970B2 Fischer-tropsch process in a radial reactor
In a process for converting synthesis gas to higher hydrocarbons in a tubular reactor, reactants are introduced through an inlet of the reactor. The reactants are passed downwardly through at least one tube to an upper surface of a catalyst carrier where they pass into a passage defined by an inner perforated wall of a catalyst container before passing radially through the catalyst bed towards the perforated outer wall. Reaction occurs as the synthesis gas contacts the catalyst. Unreacted reactant and product is passed out of the container through a perforated outer wall thereof and then upwardly between a skirt and an outer wall of the container, followed by being directed over the end of the skirt and downwardly between the skirt and the reactor tube where heat transfer takes place. These steps are repeated for any subsequent catalyst carrier, then product is removed from an outlet of the reactor.
US08906968B2 Process for bacterial stabilizing of aqueous ground natural calcium carbonate and/or precipitated calcium carbonate and/or dolomite and/or surface-reacted calcium carbonate-comprising mineral preparations
This invention discloses a process for stabilizing an aqueous mineral preparation comprising a step of adding at least one aldehyde-containing and/or aldehyde-releasing and/or phenolic and/or isothiazoline biocide to said aqueous mineral preparation.
US08906963B2 Deodorization of peracids
The present invention relates to compositions of peracids, such as peroxycarboxylic acids, having reduced odor compared to conventional peracid compositions. The invention further relates to methods employing such compositions, and methods of making these compositions. Typically, the reduced-odor antimicrobial compositions include an alcohol for the esterification reaction to remove short- to mid-chain length malodorous carboxylic acids.
US08906959B2 Vegetable oil composition containing palm mid-fraction fat and method of reducing plasma cholesterol
A method and composition for reducing the cholesterolemic effect in mammals of ingesting a blended nutritional fat composition containing a palm mid-fraction (PMF) hardstock fat combined with an unsaturated vegetable oil. The composition is solid or semi-solid at 20° C. and fluid at 35° C., and includes between 15% and 45% by weight linoleic acid. The weight ratio of disaturated triglyceride (DST) molecules to trisaturated triglyceride (TST) molecules is greater than 10:1, and the PMF hardstock fat contains approximately 50% to 95% by weight DST molecules, the majority of which contain either palmitic acid or a combination of palmitic and stearic acids at the sn-1 and sn-3 triglyceride positions and either oleic acid or linoleic acid at the sn-2 molecular position.
US08906956B2 Composition comprising (−)-Δ9-trans-tetrahydrocannabinol
A composition comprising a tetrahydrocannabinol compound, a solvent and an acid, wherein the tetrahydrocannabinol compound may be Δ8 tetrahydrocannabinol, (−)-Δ9-trans-tetrahydrocannabinol or a side chain alkyl derivative of either compound, the solvent may be an oil or C1-C4 alcohol (e.g. sesame oil or ethanol), and the acid may be an organic acid or a mineral acid.
US08906955B2 Use of adrenergic beta-3-receptor agonists in anti-aging
A method for treating an aging-related disease is disclosed comprising administering to a subject a pharmaceutical composition comprising an adrenergic beta-3-receptor agonist.
US08906954B2 Selective inhibitors of histone deacetylase
Described herein are compounds and pharmaceutical compositions containing such compounds, which inhibit the activity of histone deacetylase 8 (HDAC8). Also described herein are methods of using such HDAC8 inhibitors, alone and in combination with other compounds, for treating diseases or conditions that would benefit from inhibition of HDAC8 activity.
US08906953B2 Pyrrolidine substitute flavones for the treatment of inflammatory disorders
The present invention relates to the use of a compound of formula 1, a stereoisomer or a tautomer thereof, or a pharmaceutically acceptable salt or a pharmaceutically acceptable solvate thereof, for the treatment of an inflammatory disorder. The invention further relates to a pharmaceutical composition comprising a compound of formula 1 and at least one pharmaceutically acceptable carrier, for use in the treatment of an inflammatory disorder. The invention also relates to a method for the treatment of an inflammatory disorder by administering a therapeutically effective amount of the compound of formula 1 to a subject in need thereof.
US08906950B2 Ketorolac tromethamine compositions for treating or preventing ocular pain
Compositions comprising ketorolac tromethamine at a therapeutically effective concentration of less than 0.5% are disclosed herein. Methods of treating or preventing ocular pain using said compositions are also disclosed herein.
US08906948B2 Choline cocrystal of epalrestat
The invention relates to a novel choline cocrystal of 5-[(1Z,2E)-2-methyl-3-phenylpropenylidene]-4-oxo-2-thioxo-3-thiazolidineacetic acid. The preparation and characterization of the novel choline cocrystal according to various embodiments of the invention is described. The invention also relates to pharmaceutical compositions containing the novel choline cocrystal and the therapeutic use of the novel choline cocrystal to treat and/or prevent various conditions, including treating and/or preventing diabetic complications, treating and/or preventing homocystinuria reducing levels of homocysteine in blood serum, inhibiting aldose reductase, and affording cardioprotection in non-diabetic patients.
US08906947B2 Method for the separation and purification of epothilones
The invention discloses a method for the separation and purification of epothilones, especially discloses a method for the separation and purification of epothilones B and A using normal phase silica gel chromatography, which comprises loading the sample after dissolving the sample containing epothilones B and A with C1-C7 alkyl halide compounds or mixing the sample with silica gel, then gradient eluting silica gel column by an elution solvent of normal phase silica gel column, and finally obtaining products.
US08906945B2 Inhibitors of bacterial type III secretion system
Organic compounds showing the ability to inhibit effector toxin secretion or translocation mediated by bacterial type III secretion systems are disclosed. The disclosed type III secretion system inhibitor compounds are useful for combating infections by Gram-negative bacteria such as Salmonella spp., Shigella flexneri, Pseudomonas spp., Yersinia spp., enteropathogenic and enteroinvasive Escherichia coli, and Chlamydia spp. having such type III secretion systems.
US08906942B2 Modulators of aldhehyde dehydrogenase activity and methods of use thereof
The present invention provides compounds that function as modulators of aldehyde dehydrogenase activity; and pharmaceutical compositions comprising the compounds. The present invention provides therapeutic methods involving administering a subject compound, or a subject pharmaceutical composition.
US08906940B2 Pharmaceutical formulations useful for inhibiting acid secretion and methods for making and using them
The present invention relates to pharmaceutical formulations comprising at least one acid-labile proton pump inhibiting agent and at least one antacid, which have improved bioavailability, chemical stability, physical stability, dissolution profiles, disintegration times, safety, as well as other improved pharmacokinetic, pharmacodynamic, chemical and/or physical properties. The present invention is directed to methods, kits, combinations, and compositions for treating, preventing or reducing the risk of developing a gastrointestinal disorder or disease, or the symptoms associated with, or related to, a gastrointestinal disorder or disease in a subject in need thereof.
US08906939B2 3-cyano-4-(4-tetrahydropyran-phenyl)-pyridin-2-one derivatives
The present invention relates to novel compounds, in particular novel pyridinone derivatives according to Formula (I) including any stereochemically isomeric form thereof, or a pharmaceutically acceptable salt thereof or a solvate thereof, wherein all radicals are defined in the application and claims. The compounds according to the invention are positive allosteric modulators of metabotropic glutamate receptors subtype 2 (“mGluR2”) which are useful for the treatment or prevention of neurological and psychiatric disorders associated with glutamate dysfunction and diseases in which the mGluR2 subtype of metabotropic receptors is involved. In particular, such diseases are central nervous system disorders selected from the group of anxiety, schizophrenia, migraine, depression, and epilepsy. The invention is also directed to pharmaceutical compositions and processes to prepare such compounds and such compositions, as well as to the use of such compounds for the prevention and treatment of such diseases in which mGluR2 is involved.
US08906936B2 Pharmaceutical combination comprising co-administration of taxane and N-(1-cyclohexyl-2-{2-[4-(4-fluoro-benzoyl)-thiazol-2-yl]-pyrrolidin-1-yl}-2-oxo-ethyl)-2-methylamino-propionamide or pharmaceutically acceptable salt(s) thereof
The invention provides a pharmaceutical combination comprising: a) compounds that inhibit the binding of the Smac protein to IAPs; and b) a taxane, and a method for treating or preventing a proliferative disease using such a combination.
US08906935B2 Thiazolyl- and oxazolyl-isoquinolinones and methods for using them
The present invention relates to substituted thiazolyl- and oxazolyl-isoquinolinones that act, for example, as modulators of poly(ADP-ribose) polymerase (PARP). The present invention also relates to processes for the preparation of substituted thiazolyl- and oxazolyl-isoquinolinones and to their use in treating various diseases and disorders.
US08906933B2 Dihydropyrimidin-2(1H)-one compounds as neurokinin-3 receptor antagonists
The present invention is directed to novel dihydropyrimidin-2(1H)-one compounds useful as Neurokinin-3 (NK3) receptor antagonists, pharmaceutical compositions comprising such compounds, and methods of making and using the same.
US08906924B2 (heterocycle/tetrahydropyridine)-(piperazinyl)-1-alcanone and (heterocycle/dihydropyrrolidine)-(piperazinyl)-1-alcanone derivatives, and use thereof as p75 inhibitors
The disclosure relates to (heterocycle-tetrahydropyridine)(piperazinyl)-1-alkanone and (heterocycle-dihydropyrrolidine)(piperazinyl)-1-alkanone derivatives of formula (I): wherein A, B, m, n, W, and R2 are as defined in the disclosure; to the methods of preparing said derivatives, and to the therapeutic uses thereof.
US08906923B2 Antibacterial cyclopenta[c]pyrrole substituted 3,4-dihydro-1H-[1,8]naphthyridinones
The present invention is related to novel compounds of formula (I) that inhibit the activity of the FabI enzyme which are therefore useful in the treatment of bacterial infections. It further relates to pharmaceutical compositions comprising these compounds, and chemical processes for preparing these compounds.
US08906922B2 Substituted triazoles useful as AXl inhibitors
Substituted triazoles and pharmaceutical compositions containing the compounds are disclosed as being useful in inhibiting the activity of the receptor protein tyrosine kinase Axl. Methods of using the compounds in treating diseases or conditions associated with Axl activity are also disclosed.
US08906921B2 4-alkoxypyridazine derivatives as fast dissociating dopamine 2 receptor antagonists
The present invention relates to (1-benzyl-piperidin-4-yl)-(4-alkoxy-pyridazin-3-y1)-amines that are fast dissociating dopamine 2 receptor antagonists, processes for preparing these compounds, pharmaceutical compositions comprising these compounds as an active ingredient. The compounds find utility as medicines for treating or preventing central nervous system disorders, for example schizophrenia, by exerting an antipsychotic effect without motor side effects.
US08906919B2 Treatment of non-neuronal and non-myocardial cell, tissue and organ damage and associated pain with persistent sodium current blockers
The present invention relates to a method for slowing the development of mammalian organ, tissue and cellular damage and death by using a persistent sodium current blocker (or a pharmaceutically acceptable salt or derivative thereof). The present invention further relates to a method for preventing damage and death in mammalian organs, tissues and cells or reducing the extent of damage and death in mammalian organs, tissues and cells. In particular the invention relates to a method for the treatment, amelioration or prevention of non-neuronal and non-myocardial cell or tissue damage or death and for reducing the pain associated with non-neuronal and non-myocardial cell or tissue damage.
US08906917B2 Pyrimidine cyclohexyl glucocorticoid receptor modulators
The present invention provides a class of pyrimidinedione cyclohexyl compounds and methods of using these compounds as glucocorticoid receptor modulators.
US08906916B2 Pyrimidine derivatives as FAK inhibitors
Compounds of the formula (I), in which R1, R2 and R3 have the meanings indicated in Claim 1, are kinase inhibitors and can be employed, inter alia, for the treatment of tumors.
US08906915B2 Compounds, compositions, and methods for controlling biofilms
The invention relates to substituted 2-aminoimidazoles and their imidazo[1,2-a]pyrimidinium salts precursors being active against biofilm formation. The invention also relates to imidazo[1,2-a]pyrimidinium salts bearing an azidoalkyl substituent, and to substituted 2-aminoimidazoles wherein the amino group bears a terminal heterocyclic group such as a triazolyl group which are formed through azide-alkyne Huisgen cycloaddition starting from said imidazo[1,2-a]pyrimidinium salts bearing an azidoalkyl substituent. The invention also relates to a class of N-(azidoalkyl)pyrimidin-2-amines useful as starting materials for the synthesis of said imidazo[1,2-a]pyrimidinium salts bearing an azidoalkyl substituent. The invention also relates to antimicrobial compositions that include a microbial biofilm formation inhibiting amount of such substituted 2-aminoimidazoles or imidazo[1,2-a]pyrimidinium salts in combination with excipients. Methods for inhibiting or controlling microbial biofilm formation in a plant, a body part of a human or an animal, or a surface with which a human or an animal may come into contact are also disclosed.
US08906914B2 Ethylene diamine modulators of fatty acid hydrolase
Certain ethylene diamine compounds of Formula (I) are described, which are useful as FAAH inhibitors. Such compounds may be used in pharmaceutical compositions and methods for the treatment of disease states, disorders, and conditions mediated by fatty acid amide hydrolase (FAAH) activity, such as anxiety, pain, inflammation, sleep disorders, eating disorders, energy metabolism disorders, and movement disorders (e.g., multiple sclerosis). Methods of synthesizing such compounds are also disclosed.
US08906908B2 Hydroxybupropion analogues for treating drug dependence
The invention provides hydroxybupropion analogues capable of inhibiting the reuptake of one or more monoamines and/or acting as antagonists at nicotinic acetylcholine receptors. The compounds may selectively bind to one or more monoamine transporters, including those for dopamine, norepinephrine, and serotonin and/or may selectively bind to one or more nicotinic acetylcholine receptor subtypes. Such compounds may be used to treat conditions that are responsive to modification of monoamine levels and/or antagonism of nicotinic acetylcholine receptors, including drug dependency, depression, and obesity.
US08906905B2 Methods of treating disorders associated with protein polymerization
The present invention relates to methods of treatment of clinical disorders associated with protein polymerization comprising administering, to a subject, an effective amount of carbamazepine, oxcarbazepine or another carbamazepine-like compound. It is based, at least in part, on the discovery that, in cells having a genetic defect in α1-antitrypsin, carbamazepine was able to decrease levels of the mutant protein. Furthermore, carbamazepine reduced the hepatic load of mutant α1-antitrypsin and the toxic effect of that mutant protein accumulation, hepatic fibrosis, in vivo using a mouse model of the disease. As patients having this defect in α1-antitrypsin exhibit toxic accumulations of the protein, treatment according to the invention may be used to ameliorate symptoms and signs of disease.
US08906903B2 Topical pharmaceutical composition comprising a cholinergic agent or a calcium channel blocker
A method and composition are provided for the treatment of an anorectal disorder and for controlling the pain associated therewith. The method comprises administering to a subject in need of such treatment therapeutically effective amounts of a calcium channel blocker either alone or together with a nitric oxide donor. Amlodipine, anipamil, barnidipine, benidipine, bepridil, darodipine, diltiazem, efonidipine, felodipine, isradipine, lacidipine, lercanidipine, lidoflazine, manidipine, mepirodipine, nicardipine, nifedipine, niludipine, nilvadipine, nimodipine, nisoldipine, nitrendipine, perhexiline, tiapamil, verapamil and pharmaceutically acceptable salts thereof, are suitable calcium channel blockers.
US08906902B2 Antibacterial compounds
The present invention provides a compound of the following formula, salts, racemates, diastereomers, enantiomers, esters, carbamates, phosphates, sulfates, deuterated forms and prodrugs thereof. Also provided is the use of these compounds as antibacterials, compositions comprising them and processes for their manufacture.
US08906898B1 Solid forms of ceftolozane
Novel solid forms of ceftolozane are described, as well as methods for the preparation and use of these solid forms.
US08906897B2 Antimicrobial agents based on hemin derivatives
The invention relates to novel antimicrobial, including antibacterial and antifungal, agents and compositions based on hemin derivatives of general formula (I), and also to the production of novel hemin derivatives. The advantages of antibacterial agents based on hemin derivatives are their biocompatibility, biodegradability, high effectiveness against resistant bacteria and widespread microfungi that are harmful to humans, and freedom from toxicity and side effects.
US08906894B1 Methods for preventing and treating thrombotic disorders
Compositions and methods for anti-thrombotic and antiplatelet therapy in a subject are provided. Administration of an MAO-B inhibitor results in reduced platelet aggregation or reversion of platelet aggregation. Methods of administering an MAO-B inhibitor with at least one antiplatelet agent are also disclosed. Such combination therapies result in an additional protective effect, and in some instances a synergistic effect. The compositions and methods of the present invention are useful for treating and preventing recurrence of several cardiovascular, cerebrovascular and peripheral vascular diseases and injuries, and may be applied to subjects displaying traditional drug resistances.
US08906893B2 Substituted tetraarylbenzenes
The present invention relates to substances, to electroluminescent device comprising these substances, and to the use thereof.
US08906891B2 Na/K-ATPase ligand
This process relates to a pharmaceutical composition of an Na—K-ATPase ligand which will stimulate Na/K-ATPase signaling in a pharmaceutically acceptable vehicle. In one embodiment, the composition may be used to treat a skin disorder. In another embodiment, the composition may be used to inhibit cardiac fibrosis.
US08906890B2 Very low-dosed solid oral dosage forms for HRT
The present invention relates to a very low-dosed dosage form for hormone replacement therapy (HRT). More particularly, the present invention concerns a solid oral dosage form comprising about 0.5 mg estradiol and about 0.25 mg drospirenone, and at least one pharmaceutically acceptable excipient. Despite the very low E2 and DRSP doses it has surprisingly been found that a high proportion of the women suffering from moderate to severe hot flushes actually respond to this treatment. Accordingly, the dosage form of the invention may be used as maintenance HRT or may be used already when HRT is initiated.
US08906886B2 Composition and method for promoting survival of aged basal forebrain cholinergic neuron leading to provention and treatment of age-related neurodegenerative disorder
A method of treating a subject and preventing in a subject age-dependent basal forebrain cholinergic dysfunction related neurodegenerative disorders, comprising: administering a lipid composition comprising a therapeutically effective amount of highly enriched 1-acyl chains/2-docosahexaenoic acid containing molecular species of highly pure phospholipids to promote survival of aged basal forebrain cholinergic neurons, the phospholipids selected from the group consisting of phosphatidylserine, phosphatidylethanolamine, and phosphatidyl-monomethylethanolamine. A composition for treating a subject and preventing in a subject age-dependent basal forebrain cholinergic dysfunction related neurodegenerative disorders, the composition comprising: a lipid composition comprising: a therapeutically effective amount of highly enriched 1-acyl chains/2-docosahexaenoic acid containing molecular species of highly pure phospholipids to promote survival of aged basal forebrain cholinergic neurons, the phospholipids selected from the group consisting of phosphatidylserine, phosphatidylethanolamine, and phosphatidyl-monomethylethanolamine. A process for preparing a lipid composition comprising a therapeutically amount of natural source-based highly enriched 1-acyl chains/2-docosahexaenoic acid containing molecular species of highly pure phosphatidylserine to promote survival of aged basal forebrain cholinergic neurons; the process comprising: purifying a natural source-based phosphatidylcholine by silica chromatography; obtaining a related lysophosphatidylserine species by phospholipase A2 catalysis of transphosphatidylated natural source-based phosphatidylserine species; acylating the lysophosphatidylserine species with natural docosahexaenoic acid to form 1-acyl chains/2-docosahexaenoic acid containing phosphatidylserine species; and purifying the 1-acyl cgains/2-docosahexaenoic acid containing phosphatidylserine species by silica chromatography.
US08906882B2 Lipid conjugates in the treatment of allergic rhinitis
Provided herein are methods of treating, suppressing, inhibiting, or preventing allergic rhinitis in a subject comprising the step of administering to a subject a compound comprising a lipid or phospholipid moiety bond to a physiologically acceptable monomer, dimer, oligomer, or polymer, and/or a pharmaceutically acceptable salt or a pharmaceutical product thereof.
US08906878B2 Myocardial perfusion imaging methods and compositions
A myocardial imaging method that is accomplished by administering one or more adenosine A2A adenosine receptor agonist to a human undergoing myocardial imaging as well as pharmaceutical compositions comprising at least one A2a receptor agonist, at least one liquid carrier, and at least one co-solvent.
US08906877B2 Method for identifying agents that inhibit cell migration, promote cell adhesion and prevent metastasis
Disclosed are methods for identification of agents that modulate cell attachment, cell migration and cell viability. Cancer and primary cells adhered to a matrix are treated with agent(s) that modulate ActRII signaling and cell adhesion. Agents are tested that modulate cell adhesion, detachment, invasion and viability. Agents that modulate the expression, phosphorylation, function and translocation of ActRII signaling pathway members also can predict agents that modulate cell adhesion, detachment, invasion and viability. The methods have utility in tissue engineering as well as identifying agents that prevent cancer cell metastasis, wound dehiscence, aortic dissection and aid retina attachment and skin replacement and fertility. Examples of tissue engineering include techniques that allow for the generation of biological substitutes that restore, maintain, or improve tissue function or a whole organ.
US08906872B2 Antisense antiviral compound and method for treating ssRNA viral infection
The invention provides antisense antiviral compounds and methods of their use and production in inhibition of growth of viruses of the Flaviviridae, Picornoviridae, Caliciviridae, Togaviridae, Arteriviridae, Coronaviridae, Astroviridae and Hepeviridae families in the treatment of a viral infection. The antisense antiviral compounds are substantially uncharged morpholino oligonucleotides having a sequence of 12-40 subunits, including at least 12 subunits having a targeting sequence that is complementary to a region associated with stem-loop secondary structure within the 5′-terminal end 40 bases of the positive-sense RNA strand of the virus.
US08906870B2 MicroRNA (miRNA) for the diagnosis and treatment of heart diseases
The invention relates to microRNAs (miRNAs) for the diagnosis, prophylaxis and/or treatment of heart diseases. It relates in particular to SEQ ID No: 1 to SEQ ID No: 29 for the diagnosis, prophylaxis and/or treatment of heart diseases. In addition, the invention relates to the use of these sequences to produce a medicament for heart diseases and for the diagnosis thereof. Also encompassed are a method for the diagnosis of a heart disease, a kit and an expression vector comprising these sequences, a cell which contains the expression vector, and also a method for modulating a heart disease and a method for screening a pharmaceutically active compound for the treatment and/or prophylaxis of a heart disease.
US08906868B2 Aminoglycoside derivatives
The present invention relates to antimicrobial agents. Some embodiments include compounds, compositions, methods of preparation, and methods of treatment using new aminoglycosides and aminoglycoside derivatives.
US08906864B2 Binding domains of proteins of the repulsive guidance molecule (RGM) protein family and functional fragments thereof, and their use
The invention concerns the identification and use of neogenin receptor-binding domains of members of the repulsive guidance molecule (RGM) protein family as well as polypeptide fragments derived therefrom. The inventive domains, i.e. peptide fragments are suited as agents for the active or passive immunization of individuals as well as diagnostic and therapeutic agents for use with diseases or pathological conditions in whose origin or progression, a member of the RGM family and a cellular receptor assigned to this molecule are involved. The invention also concerns monoclonal and polyclonal antibodies directed against the inventive binding domains and against the polypeptides derived therefrom, and to method for producing the inventive domains, polypeptides and antibodies.
US08906857B2 Methods for the diagnosis and treatment of critically ill patients with endothelin, endothelin agonists and adrenomedullin antagonists
The ratio of concentrations of pro-adrenomedullin (pro-ADM)/pro-endothelin (pro-END) immunoreactivity in body fluids of critically ill patients is used as for the diagnosis, course control and prognosis, including an assessment of the mortality risk, of severe life threatening diseases. Further, a treatment of critically ill patients having high levels of pro-ADM but insufficient levels of pro-END immunoreactivities with a medicament comprising vasoconstrictive endothelin or its precursors, and/or endothelin agonists or adrenomedullin antagonists is provided.
US08906856B2 Single component fibrin hemostat
ClotGel is a single-component hemostatic agent designed for use as an adjunct or primary treatment in moderate intraoperative hemorrhage and in trauma. It can be applied topically to the wound either on the skin in a laparatomy or as non-invasive manner in surgical procedures. Its crosslinking technology generates an adhesive stable fibrin clot using a single component (fibrin II) required for hemostasis. The agent is a mixture of lyophilized polymerized fibrin II and fibrin II monomer which is polymerized and stabilized when in contact with the blood. The attachment properties of the gel, as well as the rapid formation of a fibrin clot, ensures that a strong stable fibrin clot is formed within 1 minute of application.
US08906854B2 Methods for treating metabolic disorders using FGF
The method provides methods and compositions for treating metabolic disorders such as impaired glucose tolerance, elevated blood glucose, insulin resistance, dyslipidaemia, obesity, and fatty liver.
US08906848B2 Aureobasidin derivatives and methods of synthesis
In general, the invention relates to methods of synthesizing AbA derivatives that are useful for treating infection and amenable to further chemical elaboration. These novel methods are scalable for industrial production and employ safer, simpler, and more efficient process conditions. Furthermore, the invention also provides novel compounds and intermediates useful for implementing the methods described herein and/or for the treatment of infection.
US08906844B2 Immunomodulatory peptides
The invention relates to peptides derivatized with a hydrophilic polymer which, in some embodiments, bind to human FcRn and inhibit binding of the Fc portion of an IgG to an FcRn, thereby modulating serum IgG levels. The disclosed compositions and methods may be used in some embodiments, for example, in treating autoimmune diseases and inflammatory disorders. The invention also relates, in further embodiments, to methods of using and methods of making the peptides of the invention.
US08906843B2 Functional fragrance precursor
The present invention relates to a class of fragrance precursor compounds comprising one or more of the compounds derived from the reaction of X—OH and an aldehyde or ketone, the fragrance precursor compounds being of the formula X—O—C(R)(R*)(OR**) wherein R is a C6-24 alkyl group, a C6-24 aralkyl group or a C6-24 alkaryl group; R* is H or a C6-24 alkyl group, a C6-24 aralkyl group or a C6-24 alkaryl group; R** is H or X; X—O representing a moiety derived from X—OH, and wherein X—OH is a compound selected from the group consisting of surfactants, fabric softeners, softener precursor ester amines, softener precursor amido amines, hair conditioners, skin conditions, saccharides and polymers. In a second aspect it relates to a method of preparing such precursors. Further the invention relates to compositions, comprising the precursor of the invention.
US08906839B2 Alkaline detergent containing mixing organic and inorganic sequestrants resulting in improved soil removal
Solid block alkaline detergent compositions are disclosed comprising a source of alkalinity, and other detergent additives including sequestrants. The solid block detergents of the invention used a mixed inorganic and organic sequestrant composition that successfully softens service water used in manufacturing aqueous detergents from the composition, but also obtains substantially improved organic soil removal on dishware or flatware. The solid block detergents of the invention comprise large masses of the chemical ingredients having a weight of greater than about 500 grams in a solid block product format that is typically dispensed using a spray on water dispenser that creates an aqueous concentrate that is used in a washing machine.
US08906836B2 Lubricating oil composition
Disclosed is a lubricating oil composition which includes a diester-based base oil having an asymmetric structure in which the number of carbons of the alkyl chain bound to one ester group with respect to a central atom is two more than that of the alkyl group bound to the other ester group, and which has low viscosity and a comparatively small amount of evaporation at high temperature. When this composition is used for a motor of a small hard disk, power consumption can be reduced and stability at high temperature can be enhanced.
US08906835B2 Alkali and alkaline earth thiadiazole additives and lubricating compositions containing the same
An extreme pressure additive composition for use in grease contains alkaline earth metal derivatives of 2,5-dimercapto-1,3,4-thiadiazole (DMTD) complexed to alkylene glycol fluids and or PAG fluids. In addition, additives for extreme pressure and antiwear contain a complex of alkali and/or alkaline earth metal derivatives of DMTD with alkylene glycol fluids and or PAG fluids, in combination with an organophosphorus compound.
US08906833B2 Lubricant composition
The lubricant base oil of the invention has excellent energy-conserving performance, low-temperature viscosity characteristics, and detergency. The composition contains: (A) a lubricant base oil composed of, based on the total base oil amount, 50 to 99.9 mass % of a lubricant base oil having a 100° C. kinematic viscosity of 1 to less than 5 mm2/s, and 0.1 to 50 mass % of a lubricant base oil having a 100° C. kinematic viscosity of 5 to 200 mm2/s, and (B) a viscosity index improver having average Mw of not less than 10000, and a Mw to PSSI ratio of not lower than 0.8×104, wherein the composition contains 0.1 to 50 mass % of component (B) based on the total composition amount, and has a 100° C. kinematic viscosity of 3 to 15 mm2/s and a 150° C. to 100° C. HTHS viscosity ratio of not less than 0.50.
US08906832B2 Quantitative analysis of carbohydrate-protein interactions using glycan microarrays: determination of surface and solution dissociation constants
A method, system and device to identify, study and/or mimic carbohydrate-protein interactions on cell surfaces and in solution measured by a glycan microarray. In some instances the method, system and device uses very small quantities of carbohydrate as low as attomol. In some instances the system, method and device is high-throughput. The small quantity sensitivity may allow for close placement of carbohydrate array members wherein due to close proximity multivalent interactions with proteins may be identified.
US08906828B2 Compositions and methods for post emergent weed control with clethodim and gibberellic acid
The invention relates to compositions and methods for controlling Johnsongrass or volunteer corn by application of clethodim and gibberellic acid to an area in need of weed control.
US08906826B2 Herbicidal compositions comprising 4-amino-3-chloro-5-fluoro-6-(4-chloro-2-fluoro-3-methoxyphenyl) pyridine-2-carboxylic acid or a derivative thereof and imidazolinones
A synergistic herbicidal composition containing (a) a compound of formula (I): or an agriculturally acceptable salt or ester thereof and (b) an imidazolinone, including but not limited to imazethapyr ammonium, imazamox ammonium, imazapic ammonium, imazapyr isopropylamine salt, imazamethabenz-methyl and imazaquin isopropylamine salt, provide control of undesirable vegetation e.g., in direct-seeded rice, water-seeded rice, transplanted rice, cereals, wheat, barley, oats, rye, sorghum, corn or maize, sugarcane, sunflower, oilseed rape, canola, sugar beet, soybean, cotton, pineapple, vegetables, pastures, grasslands, rangelands, fallowland, turf, tree and vine orchards, aquatics, plantation crops, vegetables, industrial vegetation management (IVM) and rights of way (ROW).
US08906822B2 Catalytic surfaces and coatings for the manufacture of petrochemicals
This disclosure describes a coating composition comprising: MnxOy, MnCr2O4, or combinations thereof in a first region of a coating having a first thickness, wherein x and y are integers between 1 and 7; and X6W6(Siz, C1-z) in a second region of the coating having a second thickness, wherein X is Ni or a mixture of Ni and one or more transition metals and z ranges from 0 to 1.
US08906820B2 Transition metal/zeolite SCR catalysts
A method of converting nitrogen oxides in a gas to nitrogen by contacting the nitrogen oxides with a nitrogenous reducing agent in the presence of a zeolite catalyst containing at least one transition metal, wherein the zeolite is a small pore zeolite containing a maximum ring size of eight tetrahedral atoms, wherein the at least one transition metal is selected from the group consisting of Cr, Mn, Fe, Co, Ce, Ni, Cu, Zn, Ga, Mo, Ru, Rh, Pd, Ag, In, Sn, Re, Ir and Pt.
US08906819B2 Method for removing calcium material from substrates
This invention is directed to a method for removing calcium material from a substrate or catalytic converter. In particular, this invention is directed to a method for removing calcium material, particularly in the form of calcium-containing fly ash, from a substrate using a partially protonated or non-protonated polycarboxylic acid treatment material.
US08906818B2 High energy density ionic dielectric materials and devices
Dielectric compositions that include compound of the formula [(M′)1−x(A′)x][(M″)1−y−z,(B″)y(C″)z]O3−δ(VO)δ and protonated dielectric compositions that include a protonated dielectric compound within the formula [(M′)1−x(A′)x](M″)1−y−z(B″)y(C″)z]O3−δ+h(Vo)δ(H•)2h are disclosed. Composite materials that employ one or more of these dielectric compounds together with an electrolyte also are disclosed. Composite material that employs one or more of these dielectric compounds together with an electrochemally active material also are disclosed.
US08906810B2 Pulsed dielectric etch process for in-situ metal hard mask shape control to enable void-free metallization
An all-in-one trench-over-via etch wherein etching of a low-k material beneath a metal hard mask of titanium nitride containing material is carried out in alternating steps of (a) etching the low-k material while maintaining chuck temperature at about 45 to 80° C. and (b) metal hard mask rounding and Ti-based residues removal while maintaining chuck temperature at about 90 to 130° C.
US08906808B2 Etching method
A metal mask having an etching pattern having a very high verticality is formed, and an etching shape having a very high verticality is formed by etching a semiconductor with the metal mask as a mask.A resist film patterned with a reversal pattern obtained by reversing an etching pattern is formed on a semiconductor (resist film forming process, S100), a metal paste is filled in the reversal pattern of the resist film (metal paste filling process, S200), a metal mask having the etching pattern is formed by removing the resist film while baking the metal paste by a heating control (metal mask forming process, S300), and plasma etching is performed on the semiconductor by using the metal mask (etching process, S400).
US08906805B2 Methods of fabricating semiconductor devices
A method of fabricating a semiconductor device includes forming a stacked structure in which 2n (here, n is an integer which is 2 or more) deposited sacrificial layers and 2n deposited insulating layers disposed on the 2n deposited sacrificial layers respectively are alternately deposited in a third direction perpendicular to a first direction and a second direction on a substrate having an upper surface extending in the first and second directions which are perpendicular to each other. Methods include forming a recess group including 2n−1 first recesses penetrating 20 through 2n−1 deposited sacrificial layers and forming a buried insulating layer group including 2n−1 buried insulating layers filling the 2n−1 first recesses respectively. A contact plug group including 2n contact plugs penetrating an uppermost deposited insulating layer of the 2n deposited insulating layers and the 2n−1 buried insulating layers may be formed.
US08906799B1 Random local metal cap layer formation for improved integrated circuit reliability
A method and structure for preventing integrated circuit failure due to electromigration and time dependent dielectric breakdown is disclosed. A randomly patterned metal cap layer is selectively formed on the metal interconnect lines (typically copper (Cu)) with an interspace distance between metal cap segments that is less than the critical length (for short-length effects). Since the diffusivity is lower for the Cu/metal cap interface than for the Cu/dielectric cap interface, the region with a metal cap serves as a diffusion barrier.
US08906798B2 Methods of manufacturing stress buffer structures in a mounting structure of a semiconductor device
A mounting structure for a semiconductor device is formed to include a stepwise stress buffer layer under a stepwise UBM structure.
US08906797B2 Microelectronic flip chip packages with solder wetting pads and associated methods of manufacturing
Processes of assembling microelectronic packages with lead frames and/or other suitable substrates are described herein. In one embodiment, a method for fabricating a semiconductor assembly includes forming an attachment area and a non-attachment area on a lead finger of a lead frame. The attachment area is more wettable to the solder ball than the non-attachment area during reflow. The method also includes contacting a solder ball carried by a semiconductor die with the attachment area of the lead finger, reflowing the solder ball while the solder ball is in contact with the attachment area of the lead finger, and controllably collapsing the solder ball to establish an electrical connection between the semiconductor die and the lead finger of the lead frame.
US08906794B1 Gate silicidation
A method for performing silicidation of gate electrodes includes providing a semiconductor device having first and second transistors with first and second gate electrodes formed on a semiconductor substrate, forming an oxide layer on the first and second gate electrodes and the semiconductor substrate, forming a cover layer on the oxide layer, and back etching the cover layer to expose portions of the oxide layer above the first and second gate electrodes while maintaining a portion of the cover layer between the first and second gate electrodes. Furthermore, the exposed portions of the oxide layer are removed from the first and second gate electrodes to expose upper portions of the first and second gate electrodes, while maintaining a portion of the oxide layer between the first and second gate electrodes, and a silicidation of the exposed upper portions of the first and second gate electrodes is performed.
US08906792B2 Impurity diffusion method, substrate processing apparatus, and method of manufacturing semiconductor device
The impurity diffusion method includes: transferring an object on which the thin film is formed into a processing chamber (operation 1); raising a temperature of the object to a vapor diffusion temperature in the processing chamber (operation 3); and supplying an impurity-containing gas that contains the impurities into the processing chamber, together with an inert gas and diffusing the impurities in the thin film formed on the object of which the temperature is raised to the vapor diffusion temperature (operation 4), wherein in the operation 4, an impurity diffusion acceleration gas for accelerating the diffusion of the impurities into the thin film is supplied into the processing chamber, together with the impurity-containing gas and the inert gas.
US08906788B2 Method for making epitaxial structure
A method for making an epitaxial structure is provided. The method includes the following steps. A substrate is provided. The substrate has an epitaxial growth surface for growing epitaxial layer. A first carbon nanotube layer is placed on the epitaxial growth surface. A first epitaxial layer is epitaxially grown on the epitaxial growth surface. A second carbon nanotube layer is placed on the first epitaxial layer. A second epitaxial layer is epitaxially grown on the first epitaxial layer.
US08906787B2 Thin film compositions and methods
Certain embodiments of the present invention include a versatile and scalable process, “patterned regrowth,” that allows for the spatially controlled synthesis of lateral junctions between electrically conductive graphene and insulating h-BN, as well as between intrinsic and substitutionally doped graphene. The resulting films form mechanically continuous sheets across these heterojunctions. These embodiments represent an element of developing atomically thin integrated circuitry and enable the fabrication of electrically isolated active and passive elements embedded in continuous, one atom thick sheets, which may be manipulated and stacked to form complex devices at the ultimate thickness limit.
US08906786B2 Method for producing single crystal SiC substrate and single crystal SiC substrate produced by the same
A single crystal SiC substrate is produced with low cost in which a polycrystalline SiC substrate with relatively low cost is used as a base material substrate where the single crystal SiC substrate has less strain, good crystallinity and large size. The method including a P-type ion introduction step for implanting P-type ions from a side of a surface Si layer 3 into an SOI substrate 1 in which the surface Si layer 3 and an embedded oxide layer 4 having a predetermined thickness are formed on an Si base material layer 2 to convert the embedded oxide layer 4 into a PSG layer 6 to lower a softening point, and an SiC forming step for heating the SOI substrate 1 having the PSG layer 6 formed therein in an atmosphere hydrocarbon-based gas to convert the surface Si layer 3 into SiC, and thereafter, cooling the resulting substrate to form a single crystal SiC layer 5 on a surface thereof.
US08906782B2 Method of separating semiconductor die using material modification
A method for separating semiconductor die includes forming a porous region on a semiconductor wafer and separating the die at the porous region using mechanical or other means.
US08906780B2 Method for transferring a thin layer of monocrystalline silicon
A method for transferring a thin layer of monocrystalline silicon from a free face of a monocrystalline silicon donor substrate having a thickness greater than that of the thin layer includes implanting ions through the free face to form a buried brittle layer in the silicon, using a polymer layer, bonding the donor substrate, by the free face, to a receiver substrate, and fracturing the thin layer from the donor substrate at the buried brittle layer by thermal fracture processing, and selecting conditions of implantation such that a thickness of the thin layer is smaller than 10 micrometers, and a thickness of the polymer layer is below a critical threshold defined as a function of energy and dose of the implantation, the critical threshold being less than or equal to the lesser of 500 nanometers and the thin layer's thickness.
US08906779B2 Solar-powered energy-autonomous silicon-on-insulator device
A solar-powered autonomous CMOS circuit structure is fabricated with monolithically integrated photovoltaic solar cells. The structure includes a device layer including an integrated circuit and a solar cell layer. Solar cell structures in the solar cell layer can be series connected during metallization of the device layer or subsequently. The device layer and the solar cell layer are formed using a silicon-on-insulator substrate. Subsequent spalling of the silicon-on-insulator substrate through the handle substrate thereof facilitates production of a relatively thin solar cell layer that can be subjected to a selective etching process to isolate the solar cell structures.
US08906774B2 Methods and compositions for doping silicon substrates with molecular monolayers
Compositions and methods for doping silicon substrates by treating the substrate with a diluted dopant solution comprising tetraethylene glycol dimethyl ether (tetraglyme) and a dopant-containing material and subsequently diffusing the dopant into the surface by rapid thermal annealing. Diethyl-1-propylphosphonate and allylboronic acid pinacol ester are preferred dopant-containing materials, and are preferably included in the diluted dopant solution in an amount ranging from about 1% to about 20%, with a dopant amount of 4% or less being more preferred.
US08906773B2 Integrated circuits including integrated passive devices and methods of manufacture thereof
Embodiments of integrated passive devices (e.g., metal insulator metal, or MIM, capacitors) and methods of their formation include depositing a composite electrode over a semiconductor substrate (e.g., on a dielectric layer above the substrate surface), and depositing an insulator layer over the composite electrode. The composite electrode includes an underlying electrode and an overlying electrode deposited on a top surface of the underlying electrode. The underlying electrode is formed from a first conductive material (e.g., AlCuW), and the overlying electrode is formed from a second, different conductive material (e.g., AlCu). The top surface of the underlying electrode may have a relatively rough surface morphology, and the top surface of the overlying electrode may have a relatively smooth surface morphology. For high frequency, high power applications, both the composite electrode and the insulator layer may be thicker than in some conventional integrated passive devices.
US08906769B2 Method of manufacturing a semiconductor device that includes a misfet
An insulating film and another insulating film are formed over a semiconductor substrate in that order to cover first, second, and third gate electrodes. The another insulating film is etched back to form sidewall spacers over side surfaces of the insulating film. Then, the sidewall spacers over the side surfaces of the insulating films corresponding to the sidewalls of the first and second gate electrodes are removed to leave the sidewall spacers over the side surfaces of the insulating film corresponding to the sidewalls of the third gate electrode. Then, the sidewall spacers and the insulating films are etched back, so that the sidewall spacers are formed of the insulating film over the sidewalls of the first, second, and third gate electrodes.
US08906767B2 Semiconductor device with self-aligned interconnects
A semiconductor device and method for fabricating a semiconductor device is disclosed. An exemplary semiconductor device includes a substrate including a metal oxide device. The metal oxide device includes first and second doped regions disposed within the substrate and interfacing in a channel region. The first and second doped regions are doped with a first type dopant. The first doped region has a different concentration of dopant than the second doped region. The metal oxide device further includes a gate structure traversing the channel region and the interface of the first and second doped regions and separating source and drain regions. The source region is formed within the first doped region and the drain region is formed within the second doped region. The source and drain regions are doped with a second type dopant. The second type dopant is opposite of the first type dopant.
US08906766B2 Method for manufacturing semiconductor device with first and second gates over buried bit line
A semiconductor device and a method for manufacturing the same are provided. The method includes forming a cell structure where a storage node contact is coupled to first and second channel layers formed on sidewalls and upper portions of a plurality of gates, thereby simplifying the manufacturing process of the device. The semiconductor device includes a bit line buried in a semiconductor substrate; the gates disposed over the semiconductor substrate buried with the bit line; a first plug disposed in a lower portion between the gates and coupled to the bit line; and a second plug coupled to the second channel layer.
US08906759B2 Silicon nitride gate encapsulation by implantation
A method of forming a FinFET structure which includes forming fins on a semiconductor substrate; forming a gate wrapping around at least one of the fins, the gate having a first surface and an opposing second surface facing the fins; depositing a hard mask on a top of the gate; angle implanting nitrogen into the first and second surfaces of the gate so as to form a nitrogen-containing layer in the gate that is below and in direct contact with the hard mask on top of the gate; forming spacers on the gate and in contact with the nitrogen-containing layer; and epitaxially depositing silicon on the at least one fin so as to form a raised source/drain. Also disclosed is a FinFET structure.
US08906757B2 Methods of forming patterns of a semiconductor device
Methods of forming patterns of a semiconductor device are provided. The methods may include forming a hard mask film on a semiconductor substrate. The methods may include forming first and second sacrificial film patterns that are spaced apart from each other on the hard mask film. The methods may include forming a first spacer on opposing sidewalls of the first sacrificial film pattern and a second spacer on opposing sidewalls of the second sacrificial film pattern. The methods may include removing the first and second sacrificial film patterns. The methods may include trimming the second spacer such that a line width of the second spacer becomes smaller than a line width of the first spacer. The methods may include forming first and second hard mask film patterns by etching the hard mask film using the first spacer and the trimmed second spacer as an etch mask.
US08906756B2 Method for manufacturing semiconductor device
An object is to provide a semiconductor device including an oxide semiconductor, which has stable electrical characteristics and high reliability. In a manufacturing process of a bottom-gate transistor including an oxide semiconductor layer, heat treatment in an atmosphere containing oxygen and heat treatment in vacuum are sequentially performed for dehydration or dehydrogenation of the oxide semiconductor layer. In addition, irradiation with light having a short wavelength is performed concurrently with the heat treatment, whereby elimination of hydrogen, OH, or the like is promoted. A transistor including an oxide semiconductor layer on which dehydration or dehydrogenation treatment is performed through such heat treatment has improved stability, so that variation in electrical characteristics of the transistor due to light irradiation or a bias-temperature stress (BT) test is suppressed.
US08906755B1 Active matrix using hybrid integrated circuit and bipolar transistor
A hybrid integrated circuit device includes a semiconductor-on-insulator substrate having a base substrate, a semiconductor layer and a dielectric layer disposed therebetween, the base substrate being reduced in thickness. First devices are formed in the semiconductor layer, the first devices being connected to first metallizations on a first side of the dielectric layer. Second devices are formed in the base substrate, the second devices being connected to second metallizations formed on a second side of the dielectric layer opposite the first side. A through via connection is configured to connect the first metallizations to the second metallizations through the dielectric layer. Pixel circuits and methods are also disclosed.
US08906753B2 Semiconductor structure and method for manufacturing the same
The present invention provides a method for manufacturing a semiconductor structure, which comprises: providing an SOI substrate, forming a gate structure on the SOI substrate; etching an SOI layer of the SOI substrate and a BOX layer of the SOI substrate on both sides of the gate structure to form trenches, the trenches exposing the BOX layer and extending partly into the BOX layer; forming sidewall spacers on sidewalls of the trenches; forming inside the trenches a metal layer covering the sidewall spacers, wherein the metal layer is in contact with the SOI layer which is under the gate structure. Accordingly, the present invention further provides a semiconductor structure formed according to aforesaid method. The manufacturing method and the semiconductor structure according to the present invention make it possible to reduce capacitance between a metal layer and a body silicon layer of an SOI substrate when a semiconductor device is in operation, which is therefore favorable for enhancing performance of the semiconductor device.
US08906752B2 Polythiophene-containing ink compositions for inkjet printing
Ink compositions comprising polythiophenes and methicone that are formulated for inkjet printing the hole injecting layer (HIL) of an organic light emitting diode (OLED) are provided. Also provided are methods of inkjet printing the HILs using the ink compositions.
US08906743B2 Semiconductor device with molded casing and package interconnect extending therethrough, and associated systems, devices, and methods
Methods for making semiconductor devices are disclosed herein. A method configured in accordance with a particular embodiment includes forming a spacer material on an encapsulant such that the encapsulant separates the spacer material from an active surface of a semiconductor device and at least one interconnect projecting away from the active surface. The method further includes molding the encapsulant such that at least a portion of the interconnect extends through the encapsulant and into the spacer material. The interconnect can include a contact surface that is substantially co-planar with the active surface of the semiconductor device for providing an electrical connection with the semiconductor device.
US08906742B2 Two-beam laser annealing with improved temperature performance
Systems and methods are disclosed for performing laser annealing in a manner that reduces or minimizes wafer surface temperature variations during the laser annealing process. The systems and methods include annealing the wafer surface with first and second laser beams that represent preheat and anneal laser beams having respective first and second intensities. The preheat laser beam brings the wafer surface temperate close to the annealing temperature and the anneal laser beam brings the wafer surface temperature up to the annealing temperature. The anneal laser beam can have a different wavelength, or the same wavelength but different orientation relative to the wafer surface. Reflectivity maps of the wafer surface at the preheat and anneal wavelengths are measured and used to select the first and second intensities that ensure good anneal temperature uniformity as a function of wafer position. The first and second intensities can also be selected to minimize edge damage or slip generation.
US08906739B2 Thin film transistor substrate and method for manufacturing same
A method includes: a step of forming a gate electrode (14) on a substrate (10a); a step of forming a gate insulating film (15) to cover the gate electrode (14), and then forming an In-Ga-Zn-O-based oxide semiconductor layer (16) in which a ratio of In:Ga:Zn in atomic % is 1:1:1 or 4:5:1 on the gate insulating film (15) to overlap the gate electrode (14); a step of forming a source electrode (19a) and a drain electrode (19b) on the oxide semiconductor layer (16) to overlap the gate electrode (14) and to face each other; and a step of performing an annealing process in an atmosphere containing steam (S) on the substrate (10a) provided with the source electrode (19a) and the drain electrode (19b).
US08906738B2 Oxide semiconductor thin film transistor with an aluminum oxide protective film made using a continuous deposition process of aluminum oxide laminated with an aluminum film
Disclosed herein is a method of manufacturing a thin film transistor having a structure that a gate electrode and an oxide semiconductor layer are disposed with a gate insulating film interposed between the gate electrode and the oxide semiconductor layer, and a source/drain electrode is electrically connected to the oxide semiconductor layer, the method including: continuously depositing an aluminum oxide (Al2O3) layer as a protective film and an aluminum (Al) layer in this order on any of the source/drain electrode, the gate insulating film, and the oxide semiconductor layer by using sputtering.
US08906736B1 Multifunctional electrode
A nonvolatile memory element is disclosed comprising a first electrode, a near-stoichiometric metal oxide memory layer having bistable resistance, and a second electrode in contact with the near-stoichiometric metal oxide memory layer. At least one electrode is a resistive electrode comprising a sub-stoichiometric transition metal nitride or oxynitride, and has a resistivity between 0.1 and 10 Ωcm. The resistive electrode provides the functionality of an embedded current-limiting resistor and also serves as a source and sink of oxygen vacancies for setting and resetting the resistance state of the metal oxide layer. Novel fabrication methods for the second electrode are also disclosed.
US08906733B2 Methods for forming nanostructures and photovoltaic cells implementing same
A method for creating a nanostructure according to one embodiment includes depositing material in a template for forming an array of nanocables; removing only a portion of the template such that the template forms an insulating layer between the nanocables; and forming at least one layer over the nanocables. A nanostructure according to one embodiment includes a nanocable having a roughened outer surface and a solid core. A nanostructure according to one embodiment includes an array of nanocables each having a roughened outer surface and a solid core, the roughened outer surface including reflective cavities; and at least one layer formed over the roughened outer surfaces of the nanocables, the at least one layer creating a photovoltaically active p-n junction. Additional systems and methods are also presented.
US08906728B2 Method for manufacturing a photodetector having a bandwidth tuned honeycomb cell photodiode structure
A photodetector with a bandwidth-tuned cell structure is provided. The photodetector is fabricated from a semiconductor substrate that is heavily doped with a first dopant. A plurality of adjoining cavities is formed in the semiconductor substrate having shared cell walls. A semiconductor well is formed in each cavity, moderately doped with a second dopant opposite in polarity to the first dopant. A layer of oxide is grown overlying the semiconductor wells and an annealing process is performed. Then, metal pillars are formed that extend into each semiconductor well having a central axis aligned with an optical path. A first electrode is connected to the metal pillar of each cell, and a second electrode connected to the semiconductor substrate. The capacitance between the first and second electrodes decreases in response to forming an increased number of semiconductor wells with a reduced diameter, and forming metal pillars with a reduced diameter.
US08906726B2 Method for making light emitting diode
A method for making light emitting diode, the method includes the following steps. First, a substrate having an epitaxial growth surface is provided. Second, a carbon nanotube layer is suspended above the epitaxial growth surface. Third, a first semiconductor layer, an active layer and a second semiconductor layer are grown on the epitaxial growth surface in that order, wherein the first semiconductor layer includes a buffer layer, an intrinsic semiconductor layer, and a doped semiconductor layer stacked in that order. Fourth, the doped semiconductor layer is exposed by removing the substrate, the buffer layer, and the intrinsic semiconductor layer. Fifth, a first electrode is prepared on the first semiconductor layer and a second electrode is prepared on the second semiconductor layer.
US08906724B2 Color stable red-emitting phosphors
A process for synthesizing a color stable Mn4+ doped phosphor includes contacting a precursor of formula I, in gaseous form at an elevated temperature with a fluorine-containing oxidizing agent to form the color stable Mn4+ doped phosphor Ax[MFy]:Mn4+  I wherein A is Li, Na, K, Rb, Cs, or a combination thereof; M is Si, Ge, Sn, Ti, Zr, Al, Ga, In, Sc, Hf, Y, La, Nb, Ta, Bi, Gd, or a combination thereof; x is the absolute value of the charge of the [MFy] ion; and y is 5, 6 or 7.
US08906721B2 Semiconductor light emitting device and method for manufacturing the same
A method for manufacturing a semiconductor light emitting device includes forming a lower cladding layer over a GaAs substrate; forming a quantum dot active layer over the lower cladding layer; forming a first semiconductor layer over the quantum dot active layer; forming a diffraction grating by etching the first semiconductor layer; forming a second semiconductor layer burying the diffraction grating; and forming an upper cladding layer having a conductive type different from that of the lower cladding layer over the second semiconductor layer, wherein the processes after forming the quantum dot active layer are performed at a temperature not thermally deteriorating or degrading quantum dots included in the quantum dot active layer.
US08906714B2 Method of manufacturing light emitting device
A method of manufacturing a light emitting device is provided which requires low cost, is easy, and has high throughput. The method of manufacturing a light emitting device is characterized in that: a solution containing a light emitting material is ejected to an anode or cathode under reduced pressure; a solvent in the solution is volatilized until the solution reaches the anode or cathode; and the remaining light emitting material is deposited on the anode or cathode to form a light emitting layer. A burning step for reduction in film thickness is not required after the solution application. Therefore, the manufacturing method, which requires low cost and is easy but which has high throughput, can be provided.
US08906711B2 Method for preparing titania pastes for use in dye-sensitized solar cells
A new, more economical method for preparing titania pastes for use in more efficient dye-sensitized solar cells is disclosed. The titania pastes are prepared by mixing titania nanoparticles with a titania sol including a titanium precursor. The disclosed method enables the control of titania nanoparticle concentration and morphology in the titania paste and is economical due to the relatively low reaction temperatures. The performances of dye-sensitized solar cells prepared using the disclosed titania pastes are also disclosed.
US08906710B2 Monitor test key of epi profile
A method and apparatus for estimating a height of an epitaxially grown semiconductor material in other semiconductor devices. The method includes epitaxially growing first, second, and third portions of semiconductor material on a first semiconductor device, measuring a height of the third portion of semiconductor material and a height of the first or second portion of semiconductor material, measuring a first saturation current through the first and second portions of semiconductor material, measuring a second saturation current through the first and third portions of semiconductor material, and preparing a model of the first saturation current relative to the height of the first or second portion of semiconductor material and the second saturation current relative to an average of the height of the first and third portions of semiconductor material. The model is used to estimate the height of an epitaxially grown semiconductor material in the other semiconductor devices.
US08906708B2 Method for checking ion implantation condition and method for manufacturing semiconductor wafer
A method for checking an ion implantation condition when ions are implanted over an entirety of one surface of a semiconductor wafer having an insulator film on the one surface, the method including checking whether the ions are implanted over the entirety of the one surface of the semiconductor wafer by directly or indirectly observing light emitted when the one surface of the semiconductor wafer is irradiated with an ion beam of the implanted ions throughout the ion implantation.
US08906704B2 Method of manufacturing a ferroelectric capacitor and a ferroelectric capacitor
A lower electrode film is formed above a substrate. A ferroelectric film is formed above the lower electrode film. An amorphous intermediate film of a perovskite-type conductive oxide is formed above the ferroelectric film. A first upper electrode film comprising oxide of at least one metal selected from a group of Pt, Pd, Rh, Ir, Ru, and Os is formed on the intermediate film. The intermediate film is crystallized by carrying out a first heat treatment in an atmosphere containing an oxidizing gas after the formation of the first upper electrode film. After the first heat treatment, a second upper electrode film comprising oxide of at least one metal selected from a group of Pt, Pd, Rh, Ir, Ru, and Os is formed on the first upper electrode film, at a temperature lower than the growth temperature for the first upper electrode film.
US08906699B2 Functionalized fluorescent nanocrystal compositions and methods for their preparation
The present invention provides for functionalized fluorescent nanocrystal compositions and methods for making these compositions. The compositions are fluorescent nanocrystals coated with at least one material. The coating material has chemical compounds or ligands with functional groups or moieties with conjugated electrons and moieties for imparting solubility to coated fluorescent nanocrystals in aqueous solutions. The coating material provides for functionalized fluorescent nanocrystal compositions which are water soluble, chemically stable, and emit light with a high quantum yield and/or luminescence efficiency when excited with light. The coating material may also have chemical compounds or ligands with moieties for bonding to target molecules and cells as well as moieties for cross-linking the coating. In the presence of reagents suitable for reacting to form capping layers, the compounds in the coating may form a capping layer on the fluorescent nanocrystal with the coating compounds operably bonded to the capping layer.
US08906697B2 Method for the assessment of particles and a system and device for use in the method
A method and a device for the assessment of at least one parameter of particles in a liquid analyte material are disclosed. The method comprises providing a device having a sample compartment with an exposing domain, an inlet through which a volume of a liquid sample representing the analyte material can been introduced, and a flow system comprising at least a channel allowing at least a portion of the volume of the liquid sample to flow within the device. The volume of the liquid sample passes into the exposing domain of the sample compartment, which can quantitatively detect spatial image data and process the detected image electromagnetic signals from the sample in the exposing domain of the device. A spatial image representation of the exposing domain, and processing the detected image presentation obtaining the assessment of the at least one parameter is generated in the device.
US08906695B1 Nanoscale spintronic chemical sensor
In general, the present disclosure is directed toward a novel hybrid spintronic device for converting chemical absorption into a change in magnetoresistance. This device uses a novel magnetic material which depends on the attachment of an organic structure to a metallic film for its magnetism. Changes in the chemical environment lead to absorption on the surface of this organometallic bilayer and thus modify its magnetic properties. The change in magnetic properties, in turn, leads to a change in the resistance of a magnetoresistive structure or a spin transistor structure, allowing a standard electrical detection of the chemical change in the sensor surface.
US08906689B2 Endoglucanase variants
The present invention relates to variant endoglucanases having improved thermoactivity, improved thermostability, and improved viscosity reduction activity over wild-type M. thermophila endoglucanase.
US08906687B2 Blood brain barrier device
Bone cages are disclosed including devices for biocompatible implantation. The structures of bone are useful for providing living cells and tissues as well as biologically active molecules to subjects.
US08906686B2 Method for preparation of implantable constructs
Neo-cartilage constructs suitable for implantation into a joint cartilage lesion in situ and a method for repair and restoration of function of injured, traumatized, aged or diseased cartilage. The construct comprises at least chondrocytes incorporated into a support matrix processed according to the algorithm comprising variable hydrostatic or atmospheric pressure or non-pressure conditions, variable rate of perfusion, variable medium composition, variable temperature, variable cell density and variable time to which the chondrocytes are subjected.
US08906682B2 Methods for treatment of cancer
The present invention provides compositions and methods for treating cancer in a human. The invention includes relates to administering a genetically modified T cell to express a CAR wherein the CAR comprises an antigen binding domain, a transmembrane domain, a costimulatory signaling region, and a CD3 zeta signaling domain.
US08906680B2 Amino acid sequences directed against chemokines and polypeptides comprising the same for the treatment of chemokine-related diseases and disorders
The present invention relates to amino acid sequences that are directed against chemokines, as well as to compounds or constructs, and in particular proteins and polypeptides, that comprise or essentially consist of one or more such amino acid sequences. The invention also relates to nucleic acids encoding such amino acid sequences and polypeptides; to methods for preparing such amino acid sequences and polypeptides; to host cells expressing or capable of expressing such amino acid sequences or polypeptides; to compositions, and in particular to pharmaceutical compositions, that comprise such amino acid sequences, polypeptides, nucleic acids and/or host cells; and to uses of such amino acid sequences or polypeptides, nucleic acids, host cells and/or compositions, in particular for prophylactic, therapeutic or diagnostic purposes.
US08906679B2 Composite for thermo-sensitive cell-tissue transplanted scaffold and use thereof
A composite comprising a stem cell; a biodegradable layer, which can provide an environment for the stem cell to grow and to differentiate, and; a N-isopropylacrylamide (NIPAAm), which can polymerize with the biodegradable layer and possess the temperature-responsive character for easy stripping. The present invention further provides a method for treating a patient with a skin defect, consisting of (a) providing said patient with a composite consisting of a N-isopropylacrylamide (NIPAAm) layer polymerized with a biodegradable layer containing gelatin and a layer of polypropylene (PP) non-woven, wherein a bone marrow derived mononuclear cell with CD45 negative and glycophorin A negative is cultivating on the biodegradable layer; (b) covering said composite on the skin defect of the patient; and (c) treating the composite with water below 25° C. to strip off the layer of polypropylene (PP) non-woven.
US08906678B2 Use of markers of undifferentiated pluripotent stem cell
The disclosure relates to methods of binding and identifying undifferentiated pluripotent stem cells and particularly, although not exclusively, to use of binding moieties which bind to PHB on the surface of undifferentiated pluripotent stem cells, such as PHB-binding peptides, and to methods for depleting undifferentiated stem cells from a sample.
US08906673B2 Automated detection and counting of biomolecules using nanoparticle probes
An apparatus and method for counting nanoparticle probes is disclosed. In one embodiment, quantum dot-tagged proteins on optically transparent membranes or slides are counted. The transparent membranes or slides are loaded onto a stage (e.g., an X-Y stage or X-Y-Z stage), which can automatically reposition the transparent membrane or slides for image capture at varying locations. A microscope can be used for providing a light source to fluoresce the nanocrystals and for providing the magnification needed for image capture. Once one or more images are captured, the nanoparticles can be automatically counted using post-processing software that maintains a total count across multiple images, if desired.
US08906671B2 Chilled reagent container and nucleic acid analyzer
A chilled reagent container comprises a reagent vessel containing part for containing therein a plurality of reagent vessels, a container lid including a container lid hole through which the reagent vessels contained by the reagent vessel containing part are accessible, and a cooling block for cooling the reagent vessels contained by the reagent vessel containing part, wherein the container lid slides to be changeable between an opened situation wherein the reagent is accessible from an outside and a closed situation wherein the reagent is prevented from being accessed from the outside, wherein the chilled reagent container further comprises a reagent container packing including another hole through which the reagent vessels are accessible and arranged between the container lid and the reagent vessel containing part to be pressed against the container lid.
US08906669B2 Microfluidic multiplexed cellular and molecular analysis device and method
A sequential flow analysis tool comprising a microfluidic device having a fluid path defined within a substrate between an input and an output is described. The device includes a capture chamber provided within but offset from the fluid path, the capture chamber extending into the substrate in a direction substantially perpendicular to the fluid path such that operably particles provided within a fluid flowing within the fluid path will preferentially collect within the capture chamber.
US08906661B2 ADAMTS-13 mutant
An enhanced disintegrin-like domain, and metalloprotease, with an isolated human thrombospondin type 1 motif, member 13 (ADAMTS-13) that includes substitutions at one or more positions in the isolated human ADAMTS-13.
US08906650B2 Yarrowia esterase/lipase promoter regions for gene expression in yeast
Promoter regions associated with the Yarrowia lipolytica esterase/lipase (EL1) gene are disclosed and have been found to be particularly effective for the expression of heterologous genes in yeast. These promoter regions will be useful for driving high-level expression of genes involved in the production of omega-3 and omega-6 fatty acids.
US08906647B2 Diamide inhibitors of cytochrome P450
Methods of inhibiting cytochrome P450 enzymes are provided that can be used for improving the treatment of diseases by preventing degradation of drugs or other molecules by cytochrome P450. Pharmaceutical compositions are provided that can act as boosters to improve the pharmacokinetics, enhance the bioavailability, and enhance the therapeutic effect of drugs that undergo in vivo degradation by cytochrome P450 enzymes.
US08906644B2 Method for culture of hepatocytes
A method for culturing hepatocytes, wherein hepatocytes embedded in an extracellular matrix is placed on a gas-permeable membrane and the hepatocytes are cultured while being supplied with oxygen from the gas-permeable membrane side. By this, the polarity in the hepatocytes can be induced and a bile canaliculus can be formed in a short period of time. Further, the formed polarity can be maintained for a longer period.
US08906643B2 Method for screening drug candidates by using domain protein
The present invention relates to a method for screening and discovering bioactive materials using specifically selected protein domains interacting with specific intracellular proteins, and more particularly, to (1) a screening method including confirmation of changes in biological activities by introducing a specific protein domain into microorganisms or animal and plant cells and (2) a screening method including confirmation of changes in biological activities after introducing the specific protein domains into a number of microorganisms or animal and plant cells. Via this method, according to the present invention, it is possible that the selected protein domains can be used to develop novel antibiotic agents with antimicrobial activity effective on bacteria resistant to conventional antibiotics while requiring less genetic information compared with a conventional drug which targets specific genes.
US08906641B2 Method for measuring animal α-amylase
It is an object of the present invention to provide a method capable of measuring a high concentration (up to 2500 U/L) of animal sample without dilutions, which is further capable of specifically measuring α-amylase even in a sample comprising animal α-amylase (EC 3.2.1.1) and glucoamylase (EC 3.2.1.3). The present invention provides a method for specifically measuring α-amylase contained in a non-human animal sample comprising α-amylase and glucoamylase without diluting said sample, wherein measurement is carried out by using an oligosaccharide having a protected nonreducing terminus and a p-nitrophenyl group at the reducing terminus thereof, and pH of reaction is 6 or more, and less than 7.
US08906635B2 Methods of diagnosing Clostridium difficile infection
Methods of diagnosing Clostridium difficile infection and compounds used in the methods are provided. The diagnostic methods are specific and sensitive methods for detecting a host cell response and, in some aspects, a target response, i.e. a Clostridium difficile toxin, in an individual infected with Clostridium difficile. The methods comprise detecting in a stool specimen or fluid exposed to the stool specimen a Clostridium difficile toxin, or a fragment thereof, and an increase in a colonic epithelial cell protein exemplified by a non-muscle tropomyosin. Also provided are kits comprising reagents for detecting host cell proteins and Clostridium difficile toxins.
US08906632B2 Use of inhibitors of leukotriene B4 receptor BLT2 for treating asthma
The present invention relates to the use of inhibitors of leukotriene B4 receptor BLT2 for treating asthma. More particularly, the present invention relates to a pharmaceutical composition for treating asthma comprising BLT2 inhibitors and a method for treating asthma using BLT2 inhibitors.
US08906631B2 Method for identifying, expanding and removing adult stem cells and cancer stem cells
Described are the use of stem cell markers for the isolation of stem cells and the use of the obtained stem cells in, for example, research or treatment, such as for the preparation of a medicament for the treatment of damaged or diseased tissue. In one aspect, provided is a method for obtaining or isolating stem cells that comprises preparing a cell suspension from a tissue or organ sample, contacting the cell suspension with an Lgr 6 or 5 binding compound, identifying the cells bound to the binding compound, and isolating the stem cells from the binding compound. Further described are methods and compositions for cancer treatment, for example, by eradicating cancer stem cells.
US08906627B2 Apparatuses and methods for manipulating droplets
Apparatuses and methods for manipulating droplets are disclosed. In one embodiment, an apparatus for manipulating droplets is provided, the apparatus including a substrate, multiple arrays of electrodes disposed on the substrate, wherein corresponding electrodes in each array are connected to a common electrical signal, and a dielectric layer disposed on the substrate first side surface and patterned to cover the electrodes.
US08906625B2 Genes involved in estrogen metabolism
The invention concerns genes that have been identified as being involved in estrogen metabolism, and are useful as diagnostic, prognostic and/or predictive markers in cancer. In particular, the invention concerns genes the tumor expression levels of which are useful in the diagnosis of cancers associated with estrogen metabolism, and/or in the prognosis of clinical outcome and/or prediction of drug response of such cancers.
US08906624B2 Rotational PCR equipment and PCR method using the same
Provided are a rotational PCR apparatus, a PCR chip for the same and a rotational PCR method using the same.The disclosed rotational PCR apparatus includes: a PCR chip where PCR is performed; a rotating means connected to the PCR chip and rotating the PCR chip; and a temperature zone forming means spaced apart from the PCR chip, capable of applying thermal energy to the PCR chip and allowing the rotating PCR chip to pass through different temperature zones. The rotational PCR apparatus and method allow performance of PCR with wanted temperature condition and cycles by rotating the chip containing the target substance. Accordingly, a high-efficiency PCR process may be accomplished at low cost. Further, since the target substance can be effectively separated and purified utilizing the centrifugal force resulting from the rotating platform, separation and purification may be achieved economically without requiring additional equipments.
US08906623B2 Kit and method for determining whether or not unmethylated cytosine conversion treatment is properly carried out and method for analyzing methylated DNA using the same
Success or failure of unmethylated cytosine conversion treatment is determined by using a first primer set comprising plural primers that hybridize with a nucleic acid comprising a nucleotide sequence not containing cytosine in the nucleotide sequence of biological DNA that is subject to an unmethylated cytosine conversion treatment and a second primer set comprising plural primers that hybridize with a nucleic acid comprising a nucleotide sequence in which cytosine in a nucleotide sequence containing cytosine and not containing a CpG site is converted into a base other than cytosine, in the nucleotide sequence of biological DNA.
US08906619B2 HDV nucleic acid molecules, fragments and applications thereof
The invention concerns nucleic acid molecules derived from novel hepatitis D virus strains or isolates constituting genotypes different from known I, II and III genotypes, their fragments, corresponding proteins and their uses as diagnostic reagents. The invention also concerns a method for sensitive diagnosis of the hepatitis D virus (or delta hepatitis virus) and a method for epidemiologic monitoring of HDV-related infections.
US08906617B2 Methods for sequencing individual nucleic acids under tension
The invention provides apparatuses and methods of use thereof for sequencing nucleic acids subjected to a force, and thus considered under tension. The methods may employ but are not dependent upon incorporation of extrinsically detectably labeled nucleotides.
US08906613B2 Method and kit for performing profiling of endarterectomy patients
A method of profiling endarterectomy patients for determining one or more post-operative risks includes steps comprising: (a) obtaining a set of parameters which describe the patient, the set of parameters including at least one of: age of patient, E; smoking habits of patient, S; serum cholesterol concentration of patient, C; diabetes status of patient, D; blood pressure of patient, P; (b) obtaining one or more samples of plaque tissue from endarterectomy treatment of the patient; (c) isolating genetic material from the one or more samples of plaque tissue; (d) determining genetic expression activities of a plurality of genes identified in the genetic material; and (e) computing from the set of parameters in combination with the genetic expression activities one or more post-operative risks indicative of potential events to which the patient is susceptible as a consequence of the endarterectomy treatment.
US08906612B2 Scaffold-based polymerase enzyme substrates
The invention provides a novel class of scaffold-based labeled polymerase enzyme substrates. The polymerase enzyme substrates have a multivalent core or scaffold to which is attached fluorescent dye moieties and nucleoside phosphate moities. The polymerase enzyme substrates have multiple fluorescent dye moities and/or multiple nucleoside phosphate moieties. Preferred multivalent cores comprise trifunctional six membered aromatic moities. The invention also provides for sequencing methods and kits with scaffold-based labeled polymerase enzyme substrates.
US08906611B2 Devices and methods for immobilizing nucleic acids
The present invention generally relates to devices and methods for immobilizing nucleic acids on a substrate. In certain embodiments, devices of the invention include a voltage source, and a substrate coupled to the voltage source, in which hydrophobicity of the substrate changes in response to an applied electric field and a surface of the substrate is coated with a substance that retains nucleic acids.
US08906609B1 Label-free biomolecule sensor based on surface charge modulated ionic conductance
The present invention provides for the detection of biochemical analytes by measuring variations in ionic conductance resulting from the hybridization of a biological analyte (e.g. oligonucleotides) with a capturing element immobilized on a membrane substrate having nano-sized pores.
US08906603B2 Modified cardiolipin and uses therefor
Compositions, methods and devices for the detection of anti-lipoidal antibodies and the diagnosis of disease, for example, syphilis, are described. In particular, oxidized cardiolipins, which may be conjugated with a variety of attachment molecules, such as BSA, KLH, biotin, synthetic protein MAPS, IgY, streptavidin, or avidin, are described. Such oxidized cardiolipin, alone or complexed with one or more attachment molecules, are useful to detect anti-lipoidal antibodies in subjects, for example, when used in lateral flow devices. Lateral flow devices are described that permit the detection of anti-lipoidal antibodies and that permit the co-detection of nontreponemal and treponemal antibodies in biological samples.
US08906599B2 Enhanced scanner throughput system and method
A method and system to improve scanner throughput is provided. An image from a reticle is projected onto a substrate using a continuous linear scanning procedure in which an entire column of die or cells of die is scanned continuously, i.e. without stepping to a different location. Each scan includes translating a substrate with respect to a fixed beam. While the substrate is translated, the reticle is also translated. When a first die or cell of die is projected onto the substrate, the reticle translates along a direction opposite the scan direction and as the scan continues along the same direction, the reticle then translates in the opposite direction of the substrate thereby forming an inverted pattern on the next die or cell. The time associated with exposing the substrate is minimized as the stepping operation only occurs after a complete column of cells is scanned.
US08906598B2 Pattern forming method, method for manufacturing semiconductor device, and material for forming coating layer of resist pattern
To provide a pattern forming method, which contains: forming a first resist pattern on a processing surface using a first resist composition; forming a coating layer using a coating material so as to cover a surface of the first resist pattern; applying a second resist composition over the first resist pattern above which the coating layer has been formed so as not to dissolve the first resist pattern with the second resist composition to thereby form a second resist film; and selectively exposing the second resist film to exposure light and developing the second resist film to thereby expose the first resist pattern to the air, as well as forming a second resist pattern in an area of the processing surface where the first resist pattern has not been formed.
US08906596B2 Method of marking a metal component surface with modifying sequences in which the segments of the markings are formed
The present invention resides in a method of providing a mark on a surface of a metal component, where the mark comprises a symbol (301) representing a first entity of information and the method comprises a step of laser marking, in which a controllable laser beam is used to form the symbol (301) from two or more separate line segments (33 1-334), each line segment (33 1.334) having at least one point of overlap with another line segment. According to the invention, the method further comprises a step of embedding a second entity of information within the mark by modifying a sequence in which the two or more separate line segments (33 1-334) are formed.
US08906587B2 Colored resin powder and toner using the colored resin powder
Provided is a colored resin powder which can reproduce even high lightness and saturation and has spectral reflectance characteristic having a wide gamut. The colored resin powder includes a water-insoluble coloring matter compound represented by the following general formula (1) and a binder resin: in which in the general formula (1), R1 and R2 each independently represent an alkyl group, and R3 represents one of an alkyl group, an aryl group, and an alkoxy group.
US08906585B2 Method of manufacturing semiconductor device and exposure device
A method of manufacturing a semiconductor device in which the alignment accuracy of an immersion exposure device is maintained even when exposure steps are carried out intermittently. In the method, a substrate is placed on a stage of an exposure device (substrate placing step). Then, a first liquid is supplied to between the substrate and the optics system of the exposure device to expose the substrate through the first liquid (exposure step). A second liquid is supplied from a different place from the first liquid to a drainage groove provided around the stage at least in a period other than when the first liquid is supplied onto the stage, in order to suppress change in the temperature of the exposure device.
US08906579B2 Low contact resistance coated stainless steel bipolar plates for fuel cells
A bipolar plate to reduce electrical contact resistance between the plate and a diffusion layer used in a fuel cell. The opposing surfaces of the plate define flow channels with upstanding lands interspersed between them. The lands of the plate form an electrically-conductive contact with a diffusion layer in the fuel cell. At least a portion of the electrically-conductive contact is made up of a nickel-based alloy that reduces the contact resistance between the plate and the diffusion layer as a way to achieve improved electric current density. In one form, the alloy can be used as the primary material in the plate, while in another, it can be used as a coating deposited onto a conventional stainless steel plate.
US08906578B2 Fuel cell flow field plate having catalyst disposed in microreaction chambers, and method for producing thereof
A fuel cell, having a first electrode, a second electrode, and a membrane element, in which the membrane element is disposed between the first electrode and the second electrode. At least one of the electrodes has a flow field plate and at least one flow conduit, through which a reactant can be conducted, extends in at least one outer surface of the flow field plate. The flow field plate has at least one microreaction chamber, and the microreaction chamber is disposed in the outer surface and on the flow conduit. A catalyst is disposed on at least a part of the microreaction chamber in such a way that the catalyst has contact simultaneously with the membrane element and the inflowing reactant.
US08906577B2 High performance flame fuel cell using an anode supported solid-oxide fuel cell
The present invention relates to an anode supported solid-oxide fuel cell based flame fuel cell that enable the generation of both electricity and heat from a flame (i.e. flame is used as a heat source and a fuel source for the fuel cell's operation, while supplying a useful heat for other thermochemical systems) and, more particularly, to an anode supported solid-oxide fuel cell based flame fuel cell that uses hydrocarbon/air mixture as a fuel source and includes a catalyst layer that can act as a protective layer for the anode layer, an anode layer, a cathode layer, an electrolyte layer, and an interlayer between the cathode layer and the electrolyte layer.
US08906575B2 Minimizing electrode contamination in an electrochemical cell
An electrochemical cell assembly that is expected to prevent or at least minimize electrode contamination includes one or more getters that trap a component or components leached from a first electrode and prevents or at least minimizes them from contaminating a second electrode.
US08906569B2 Heat exchanger for a hot fuel cell
A heat exchanger for operating at an outlet of a hot fuel cell feeding the heat exchanger with oxidizer gas and with fuel gas, the heat exchanger including: a first flow circuit for oxidizer gas; a second flow circuit for fuel gas; a pre-mixer chamber fed both with oxidizer gas and with fuel gas from at least the second circuit; a combustion chamber fed with the gaseous mixture from the pre-mixer chamber and with oxidizer gas from the first circuit; and a flow circuit for flue gas, receiving the flue gas coming from the combustion chamber. The first flow circuit for oxidizer gas, the second flow circuit for fuel gas, the combustion chamber, and the flow circuit for flue gas are immersed in a common cooling fluid.
US08906565B2 Method for load following operation of fuel cell system
Two or more methods selected among a steam reforming method, a partial oxidation reforming method, and an autothermal reforming method are defined as i-th reforming method. Functions Fi=fi(P), P=fi−1(Fi), and ηi=gi(P) are obtained in advance. If there is a number i which satisfies FiR≧Fimin, the following process (1) is performed when PD≦P is satisfied, and the following process (2) is performed when PD>PiM is satisfied. In the process (1), if fi(PD)≦FiR is satisfied, Pi*=PD and Fi*=fi(PD), and if fi(PD)>FiR is satisfied, Pi*=(the maximum fi−1(FiR) which is less than PD) and Fi*=FiR. In the process (2), if fi(PiM)≦FiR is satisfied, Pi*=PiM and Fi*=fi(PiM), and if fi(PiM)>FiR is satisfied, Pi*=(the maximum fi−1(FiR)) and Fi*=FiR. If there are a plurality of numbers i which satisfy FiR≧Fimin, PI*, a reforming method, and FI*, which relate to the number i which provides the maximal ηi=gi(Pi*), are adopted.
US08906564B2 Hydrogen generator, fuel cell system, and method for operating hydrogen generator
The possibility of carbon deposition from a raw material gas is made lower than before in a pressure compensating operation carried out after stopping the stop process of a hydrogen generator and a fuel cell system including the hydrogen generator.The hydrogen generator includes: a raw material supply unit (102, 103) configured to function to block supply of a raw material; a steam supply unit (104, 105) configured to function to block supply of steam; a reformer 108 including a reforming catalyst 109 and configured to generate a hydrogen-containing gas by using the raw material supplied from the raw material supply unit and the steam supplied from the steam supply unit; a closing unit 116 configured to block at least a gas passage provided downstream of the reformer; and a controller 140 configured to execute a pressure compensating operation in which: during stop of the hydrogen generator, with hydrogen contained in the reformer, the supply of the raw material from the raw material supply unit and the supply of the steam from the steam supply unit are blocked, and the closing unit is closed; and to compensate a pressure decrease in the reformer due to a temperature decrease in the reformer after the closing of the closing unit, with the hydrogen contained in the reformer, the steam is supplied from the steam supply unit to the reformer.
US08906562B2 Polymeric compound, oxygen permeable membrane, oxygen permeable composite, electrochemical device
A polymeric compound having a backbone structure including an addition product of a (meth)acrylate compound and a nucleophile of a cobalt porphyrin complex including a tetraphenylporphyrin derivative represented by Formula 1 coordinated to a cobalt metal, wherein substituents R1 to R4 are as described in the specification, an oxygen permeable membrane including the polymeric compound, and an electrochemical device including the oxygen permeable membrane.
US08906557B2 Anode active material and method of preparing the same
Anode active materials and methods of preparing the same are provided. One anode active material includes a carbonaceous material capable of improving battery cycle characteristics. The carbonaceous material bonds to and coats metal active material particles and fibrous metallic particles to suppress volumetric changes.
US08906552B2 Lithium iron phosphate of olivine crystal structure and lithium secondary battery using the same
Disclosed is lithium iron phosphate having an olivine crystal structure wherein carbon (C) is coated on particle surfaces of the lithium iron phosphate, wherein, when a powder of the lithium iron phosphate is dispersed in water, water is removed from the resulting dispersion and the resulting lithium iron phosphate residue is quantitatively analyzed, a ratio of the carbon-released lithium iron phosphate with respect to the total weight of the carbon-coated lithium iron phosphate is 0.005% by weight or less. Advantageously, the olivine-type lithium iron phosphate is not readily separated through uniform thin film coating on the surface of the lithium iron phosphate and exhibits superior conductivity and density, since carbon is coated on particle surfaces of lithium iron phosphate in a state in which the amount of carbon released in water is considerably small.
US08906549B1 Development of mixed binder system for primary cell cathodes
The invention is directed to an SVO electrochemical cell having high rate capability. The cathode is produced by coating a mixture of an active material, conductive additives, a mixed binder, and an aluminum foil current collector. The mixed binder consists of a mixture of styrene butadiene with PVDF. The use of the styrene butadiene maintains adhesion to the conductive current collector while the PVDF portion of the binder gives flexibility. A particularly preferred couple is of a lithium/silver vanadium oxide (Li/SVO) chemistry and the binder mixture enables an active slurry of SVO to be coated onto a current collector without delamination.
US08906545B2 Prismatic secondary battery
A crimped portion of a positive electrode external terminal is crimped on its upper end side to be electrically connected to a positive electrode terminal plate. This crimped portion is welded to the positive electrode terminal plate by applying high energy beams. The negative electrode side has a configuration similar to that of the positive electrode side. The contact area between the positive electrode terminal plate and the crimped portion of the positive electrode external terminal is set smaller than the corresponding contact area on the negative electrode side, and the volume of the crimped portion of the positive electrode external terminal is set larger than that of the corresponding crimped portion on the negative electrode side. Thus, a prismatic secondary battery is provided that shows strong joining strength between the external terminal and the terminal plate, suppressed internal resistance variations, and improved reliability.
US08906539B2 Polyolefin composition, its production method, and a battery separator made therefrom
The invention relates to a polyolefin composition. The polyolefin composition can be in the form of a multi-layer, microporous polyolefin membrane comprising a first microporous layer containing 7% or less by mass of ultra-high-molecular-weight polyethylene having a weight-average molecular weight of 1×106 or more, and having a structure in which a pore size distribution curve obtained by mercury intrusion porosimetry has at least two peaks, and a second microporous layer containing 8% or more by mass of the ultra-high-molecular-weight polyethylene.
US08906536B2 Cable-type secondary battery
The present invention relates to a cable-type secondary battery having a horizontal cross section of a predetermined shape and extending longitudinally, comprising: a core for supplying lithium ions, which comprises an electrolyte; an inner electrode, comprising an open-structured inner current collector surrounding the outer surface of the core for supplying lithium ions, an inner electrode active material layer formed on the surface of the inner current collector, and an electrolyte-absorbing layer formed on the outer surface of the inner electrode active material layer; a separation layer surrounding the outer surface of the inner electrode to prevent a short circuit between electrodes; and an outer electrode surrounding the outer surface of the separation layer and comprising an outer electrode active material layer and an outer current collector.
US08906530B2 Battery unit with blower
A battery unit includes a battery housing, a module assembly, electrode portions, fins and a blower. The module assembly includes battery modules having positive terminals and negative terminals. The electrode portions are disposed to connect the positive and negative terminals of the battery modules. The fins are disposed along the electrode portions. The module assembly defines a first surface and a second surface along a stacking direction of the battery modules. The blower is disposed to supply air toward the fins over a range substantially equal to a dimension of the module assembly in the stacking direction. A rotation shaft of the blower is located between a first plane that includes the first surface of the module assembly and a second plane that includes the second surface of the module assembly. The fins have surface areas that increase toward a downstream location with respect to a flow of the air.
US08906525B2 Energy storage device cell
Provided is an energy storage device cell capable of enhancing energy density. The energy storage device cell includes: a battery main body including battery anode plate members and battery cathode plate members, in which the battery cathode plate members are placed at both ends in a stack direction; common anode plate members each including a common anode collector foil having a through-hole formed therein and common anode electrode layers, the common anode plate members being stacked on the battery cathode plate members placed at both ends in the stack direction of the battery main body; capacitor cathode plate members each including a capacitor cathode collector foil and a capacitor cathode electrode layer, in which the capacitor cathode electrode layer is placed between the common anode plate member and the capacitor cathode collector foil.
US08906524B2 Secondary battery having a modular frame to support a protection circuit module
A secondary battery includes a module frame capable of supporting a protection circuit module in a stable manner. The secondary battery includes a bare cell including a cap plate, a protection circuit module, and a module frame provided between the cap plate and the protection circuit module to support the protection circuit module. The module frame is made of a conductive material to electrically connect the cap plate and the protection circuit module to each other.
US08906520B2 Sulfonated polythiophenes comprising fused ring repeat units
A sulfonated polymer comprising a 3-substituted fused thienothiophene repeat unit, a composition comprising the polymer, a method of making the polymer, and a device comprising the polymer. The polymers can be used in hole injection or hole transport layers, or other applications in organic electronic devices.
US08906519B2 Oligoaniline compounds
An oligoaniline compound represented by the formula (1) can provide a charge transporting thin film which shows a suppressed coloration in the visible range. Use of this thin film makes it possible to ensure a color reproducibility of a device without lowering the color purity of an electroluminescent light or a light having passed through a color filter. wherein R1 to R10 independently represent each a hydrogen atom, a halogen, etc.; m and n independently represent each an integer of 1 or more while satisfying the condition m+n≦20; and X is a structure represented by any of the following formulae (4) to (10), etc.; wherein R21 to R36 independently represent each a hydrogen atom, a hydroxyl group, etc.; p and q represent each an integer of 1 or more while satisfying the conditions p≦20 and q≦20; and W1s independently represent each —(CR1R2)p-, —O—, —S—, etc.
US08906517B2 Organic electroluminescence device
An organic electroluminescence device including a lower electrode disposed on a substrate, an organic layer having at least a light emission layer and disposed above the lower electrode, and upper electrode having a transparent conductive film and disposed above the organic layer, in which the device has an electron injecting layer between the organic layer and the upper electrode. The electron injecting layer has a buffer layer comprising an insulative material and a mixed layer comprising an organic material that has an electron transporting property and a metal material that has an electron injecting property.
US08906515B2 Metal-clad polymer article
Metal-clad polymer articles containing structural fine-grained and/or amorphous metallic coatings/layers optionally containing solid particulates dispersed therein, are disclosed. The fine-grained and/or amorphous metallic coatings are particularly suited for strong and lightweight articles, precision molds, sporting goods, automotive parts and components exposed to thermal cycling although the coefficient of linear thermal expansion (CLTE) of the metallic layer and the substrate are mismatched. The interface between the metallic layer and the polymer is suitably pretreated to withstand thermal cycling without failure.
US08906514B2 Reinforcement material for rubber, rubber product using the material and method for producing the product, pneumatic tire using the material and method for producing the tire
Provided are a reinforcement material, not causing undesired stress and having excellent shape stability characteristics, a rubber product using the material and a method for producing the product, and a pneumatic tire using the material and a method for producing the tire. The reinforcement material for rubber has a flat coil shape where, when the material is in a single free state, loop portions are partly superposed on each other in sequence, and is embedded in a rubber product such as a pneumatic tire.
US08906513B2 Fuser member
The present teachings provide a fuser member. The fuser member includes a substrate layer comprising a polyamideimide/polybenzimidazole polymer blend. A method of manufacturing the fuser member is described.
US08906511B2 Alumina forming bimetallic tube and method of making and using
Provided is a bimetallic tube for transport of hydrocarbon feedstocks in a petrochemical process unit and/or refinery process unit, including: i) an outer tube layer being formed from a steam cracker alloy including at least 18.0 wt. % Cr and at least 10.0 wt. % Ni; ii) an inner tube layer being formed from an alumina forming bulk alloy including 5.0 to 10.0 wt. % of Al, 18.0 wt. % to 25.0 wt. % Cr, less than 0.5 wt. % Si, and at least 35.0 wt. % Fe with the balance being Ni, wherein the inner tube layer is formed plasma powder welding the alumina forming bulk alloy on the inner surface of the outer tube layer; and iii) an oxide layer formed on the surface of the inner tube layer, wherein the oxide layer is substantially comprised of alumina, chromia, silica, mullite, spinels, or mixtures thereof.
US08906510B2 Film composition and method of making the same
This disclosure relates to a film comprising a metal receiving layer, the first layer comprising a blend of a first polymer and 5-25 wt. % of a second polymer, the second polymer is a metallocene-catalyzed elastomeric ethylene-propylene copolymer having an ethylene content of less than or equal to 10 wt. %, the first polymer is different from the second polymer.
US08906503B2 Fine particles of crystalline polyol, and method of preparing same
Fine particles of crystalline polyol are provided having a cationic polymer fixed on the crystal surfaces. These fine particles can stably carry an anionically charged compound on their surfaces.
US08906500B2 Engineered composite building materials and methods of making same
An engineered composite building material, such as fiber cement, having one or more engineered sub-surface regions designed to provide the building material with improved moisture ingress resistance, paint adhesion, and other mechanical properties is provided. The sub-surface region has a cement-polymer matrix formed by introducing an impregnating agent into the pores of the substrate. The composite building material may be formed by applying impregnating agents to the subsurface regions of the substrate to form chemical and/or mechanical bonds with the matrix of the building material, the reinforcement fibers, and/or the surface coatings applied to the material. The thickness of the sub-surface regions may be controlled by varying the viscosity and porosity of the building material substrate. The cement-polymer building material has enhanced durability, weather resistance, strength, and stiffness.
US08906497B2 Foam element with hydrophilic substances incorporated in it
The invention relates to a foam element (7) made from a foam and particles (11) of at least one hydrophilic substance such as cellulose, superabsorbers. The foam element (7) containing the particles (11) has a reversible capacity to absorb moisture. A part of the particles (11) is completely embedded in the foam. Another part of the particles (11) is disposed protruding out from a surface (13) of the foam, such as cell walls (9) or cell webs (10). The foam without the hydrophilic substance has an absorption capacity of more than 2.8% by weight at an equilibrium moisture corresponding to a temperature of 23° C.
US08906496B2 Sliding member and image-fixing device
An object is to provide a sliding member having improved lubricant retention capacity without deteriorating the strength of a woven fabric. The sliding member includes: a fabric woven with a yarn containing a fiber bundle of fluororesin; and a lubricant attached to the fabric. In the sliding member, the fluororesin may be polytetrafluoroethylene (e.g., expanded polytetrafluoroethylene). An oil may be used as the lubricant. The sliding member can be used in an image-fixing device.
US08906495B2 Polymer-carbon nanotube composites
This invention relates to a composite comprising carbon nanotubes coated with a polymer, wherein the polymer comprises at least one hydrophobic monomer unit. This invention also relates to a process for the production of a composite comprising a polymer and carbon nanotubes.
US08906494B2 Process for producing composite prepreg base, layered base, and fiber-reinforced plastic
A composite prepreg base includes a raw prepreg base comprising a fiber sheet including discontinuous reinforcing fibers arranged in one direction and having a fiber length of 1-300 mm and a matrix resin infiltrated into the fiber sheet; and an additional resin layer formed on at least one surface of the raw prepreg base. The composite prepreg base is produced by a process including (i) the step of preparing the raw prepreg base and (ii) the step of forming an additional resin layer on at least one surface of the raw prepreg base prepared. A layered base includes two or more sheets of the composite prepreg base which have been superposed so that the additional resin layer is present on at least one surface; and a fiber-reinforced plastic formed by heating and pressing the layered base.
US08906492B2 Formed article, method for producing the formed article, member for electronic device, and electronic device
A formed article includes a gas barrier layer that is formed of a material including at least an oxygen atom and a silicon atom, a surface area of the gas barrier layer having an oxygen atom content rate of 60 to 75%, a nitrogen atom content rate of 0 to 10%, and a silicon atom content rate of 25 to 35%, based on the total content of oxygen atoms, nitrogen atoms, and silicon atoms, and having a film density of 2.4 to 4.0 g/cm3. A method of producing a formed article includes implanting ions into a surface layer part of a polysilazane compound-containing layer of a formed body that includes the polysilazane compound-containing layer in its surface layer part. An electronic device member includes the formed article. An electronic device includes the electronic device member. The formed article exhibits an excellent gas barrier capability, excellent folding resistance, and excellent transparency.
US08906491B2 Multi-layer body and method for producing the same
Described is a multi-layer body (1), in particular a transfer film, having a replication lacquer layer and a metallic layer which is arranged on the replication lacquer layer and which has a plurality of microscopically fine pattern regions (14m) and a background region (14d) completely surrounding each of the pattern regions (14m), wherein the pattern regions (14m) are arranged in a raster (14r) of the raster width D and the pattern regions are respectively arranged separated from each other at a spacing B by the background region. Also described is a process for the production of such a multi-layer body.
US08906490B2 Multicolor mask
The invention relates to a process for forming a stacked transparent structure comprising providing a support, coating one side of said support with a multicolored mask, coating the other side of the support with a layer curable by visible light, and exposing the light-curable layer through the mask with visible light to cure the layer curable by light in exposed portions to form a cured pattern.
US08906489B2 Method for producing a fibre composite component for aviation and spaceflight
Method for producing a fiber composite component, in particular for aerospace, having the following method steps: forming a moulding core that comprises a predetermined number of hollow bodies for defining an external geometry of the moulding core, the hollow bodies being designed such that they extend in the longitudinal direction of the moulding core and are expandable elastically at least in their lateral direction, and are fixed to one another, the formed moulding core having a flexible outer layer for smoothing the contour of its outer surfaces, and a core sleeve surrounding the moulding core, for sealing the moulding core from the fiber composite component to be produced; placing at least one fiber semi-finished product, at least in places, on the moulding core (that has been formed, in order to shape at least one moulding section of the fiber composite component to be produced; and applying heat and/or pressure to the at least one moulding section in order to produce the fiber composite component.
US08906487B2 Base material with single-crystal silicon carbide film, method of producing single-crystal silicon carbide film, and method of producing base material with single-crystal silicon carbide film
In a base material with a single-crystal silicon carbide film according to an embodiment of the invention, a plurality of recessed portions is formed on the surface of a silicon substrate, an insulating film including silicon oxide is formed across the surface of the silicon substrate including the inner surfaces of the recessed portions, the top surfaces of side wall portions of recessed portions of the insulating film form flat surfaces, a single-crystal silicon carbide film is joined on the flat surfaces, and the recessed portions below the single-crystal silicon carbide film form holes.
US08906478B2 Films for inflatable cushions
Films for inflatable cushions are disclosed. Generally, each of the disclosed films includes a pair of web layers that are aligned to be generally coextensive and that are sealed together by longitudinal and/or transverse seals that cooperatively define the boundaries of inflatable chambers.
US08906473B2 Liquid crystal display device
A liquid crystal display device includes: a pair of substrates at least one of which is transparent; a liquid crystal layer disposed between the pair of substrates; an electrode group formed on at least one substrate of the pair of substrates, for applying an electric field to the liquid crystal layer; a plurality of active elements connected to the electrode group; and a liquid crystal alignment film disposed on at least one substrate of the pair of substrates, in which the liquid crystal alignment film, which is formed by a photo-alignment process, contains polyimide formed using tetracarboxylic acid dianhydride and/or diamine each having a specific chemical structure.
US08906468B2 Low gloss UV-cured coatings for aircraft
A method of applying a low gloss coating to a substrate such as the exterior surface of an aircraft is disclosed. The coating composition comprising a polyene, a polythiol, a flatting agent and a coloring pigment is applied to the substrate and given a first dosage of UV radiation followed by a second dosage in which the second dosage is greater than the first resulting in an ultralow gloss coating.
US08906467B2 Electrostatic spray apparatus and method
Target substrates are electrostatically coated by flowing an electrically isolated wet coating composition containing waterborne coalescable polymeric binder into an electrostatic coating apparatus (100), depositing the coating composition onto a rotating electrostatically-charged atomizer (104) and then onto the target substrate, flowing an electrically isolated aqueous cleaning liquid into the apparatus before deposition of the coating composition onto the rotating atomizer is halted or interrupted, and depositing the aqueous cleaning liquid onto the atomizer before or within a sufficiently short time after a halt or interruption in coating composition deposition onto the atomizer so that a coalesced polymeric binder film does not accumulate on the atomizer.
US08906464B2 Ceramic mediums and inks in powder form
The disclosure relates to printing mediums, useful for ceramic sinterable materials, that are in powder form and are based on glycols, urea and an inorganic absorbent, to ceramic inks compositions comprising the printing mediums and to methods for decorating green or fired ceramic bodies by the use of said printing mediums and compositions.
US08906463B2 Method for producing polyimide film and polyamic acid solution composition
Disclosed is a method for producing a polyimide film, wherein a polyamic acid solution composition is coated on a base material and the resultant coating film is processed by heat treatment; the polyamic acid solution composition is obtained by introducing a specific chemical structure into a polyamic acid at a ratio within a specific range; and the polyamic acid has a chemical structure composed of a 3,3′,4,4′-biphenyltetracarboxylic acid component and/or a pyromellitic acid component, and a paraphenylenediamine component. Also disclosed is the polyamic acid solution composition.
US08906462B2 Melt formulation process for preparing structured organic films
Processes for preparing structured organic films (SOFs) comprising a plurality of segments and a plurality of linkers arranged as a covalent organic framework. The processes for preparing structured organic film may include mixing a plurality of molecular building blocks each comprising a segment and a number of functional groups to form a mixture of molecular building blocks; heating the mixture to form a homogeneous liquid comprising pre-SOFs; depositing the homogeneous liquid comprising pre-SOFs as a wet layer; and drying the wet layer to form a dry SOF from the pre-SOFs.
US08906461B2 Rapid drying lacquers containing triblock copolymer for rheology control
This invention relates to rapid drying lacquers that are particularly useful for automotive OEM refinish applications. The lacquer includes a novel acrylic triblock copolymer as a replacement material for all or part of the cellulose acetate butyrate binder component. This invention is also directed to a process for producing coatings from the rapid drying lacquers. These lacquers are especially useful in providing chip and humidity resistant coatings, especially metallic effect coatings, having excellent adhesion and down flop or metallic effect.
US08906459B2 Method of forming organic layer and method of manufacturing organic light emitting device having the same
A method of forming an organic layer includes supplying a liquefied organic material, drying the liquefied organic material, supplying a solvent to an intermediate organic layer to swell the intermediate organic layer, and drying the swelled organic layer. The organic layer is formed to have a uniform thickness when the organic layer is formed by a solution-based printing method.
US08906455B2 Low temperature deposition of silicon-containing films
This invention discloses the method of forming silicon nitride, silicon oxynitride, silicon oxide, carbon-doped silicon nitride, carbon-doped silicon oxide and carbon-doped oxynitride films at low deposition temperatures. The silicon containing precursors used for the deposition are monochlorosilane (MCS) and monochloroalkylsilanes. The method is preferably carried out by using plasma enhanced atomic layer deposition, plasma enhanced chemical vapor deposition, and plasma enhanced cyclic chemical vapor deposition.
US08906453B2 Tool for harvesting polycrystalline silicon-coated rods from a chemical vapor deposition reactor
A tool for harvesting polycrystalline silicon-coated rods from a chemical vapor deposition reactor includes a body including outer walls sized for enclosing the rods within the outer walls. Each outer wall includes a door for allowing access to at least one of the rods.
US08906451B2 Method for producing coated water-soluble particles
A method for producing coated water-soluble particles in a manner to form two or more coating layers on surfaces of the water-soluble particles, characterized by including: a step A wherein after supplying a first coating material that contains a polyol component and an isocyanate component, a second coating material is additionally supplied to surfaces of first coating bodies that have coating layers formed of the first coating material that has not been sufficiently cured, so that second coating bodies that are provided with coating layers of the second coating material are obtained.
US08906450B1 Cold spray system nozzle
A powder spray nozzle includes an inlet portion having an inlet diameter and an inlet length and an outlet portion having outlet diameter and an outlet length. The nozzle also includes an interface region between the inlet portion and the outlet portion having an interface diameter. A ratio of the inlet diameter to the inlet length is in a range of about 0.15 to 0.5.
US08906449B2 Method for making cathode composite material for lithium ion batteries
A method for making a cathode composite material of a lithium ion battery is disclosed. In the method, a composite precursor is formed. The composite precursor includes a cathode active material precursor and a coating layer precursor coated on a surface of the cathode active material precursor. The composite precursor is reacted with a lithium source chemical compound, to lithiate both the cathode active material precursor and the coating layer precursor in the composite precursor.
US08906445B2 Shadow mask and method of fabricating organic light-emitting device using the same
A shadow mask and a method of fabricating an OLED display using the same is disclosed, wherein the shadow mask is not sagging, and the shadow mask includes a plurality of columns, each column including a plurality of first or second cell-forming parts, wherein the first and second cell-forming parts are alternately arranged in the columns, and the first and second cell-forming parts provided in the adjacent columns include transmission parts having the different open directions.
US08906444B2 Diazonium salt modification of silk polymer
A method for modifying silk polymer by coupling a chemical moiety to a tyrosine residue of a silk polymer is described herein for the purpose of altering the physical properties of the silk protein. Thus, silk proteins with desired physical properties can be produced by the methods described herein. These methods are particularly useful when the introduction of cells to a mammal is desired, since modifications to the silk protein affect the physical properties and thus the adhesion, metabolic activity and cell morphology of the desired cells. The silk protein can be modified to produce, or modify, a structure that provides an optimal environment for the desired cells.
US08906438B2 Container for holding and dispensing a pressurised beverage
Holder (1) for beverage, comprising a container (2) manufactured substantially from plastic, provided with a neck (6) having an opening, wherein the container (2) is filled with beverage (3) and on or in the neck (6) a closure (15) is provided, through which closure extends a dispensing means (4), wherein the closure is fixed to the neck with the aid of at least welding technique and wherein a pressure device (9) is provided for pressurizing the beverage (3) in the container (2) for dispensing the beverage (3) under pressure via the dispensing means (4).
US08906435B2 System, method and capsule for preparing a beverage
A system for preparing a beverage includes an exchangeable capsule, an apparatus including a receptacle for holding the exchangeable capsule, and a fluid dispensing device for supplying a fluid to the exchangeable capsule. The exchangeable capsule includes a circumferential wall, a bottom, and a lid. The wall, bottom and lid enclose an inner space including the extractable product. The receptacle includes bottom piercing means for piercing an entrance area of an alternative capsule for creating an entrance opening for supplying the fluid to the extractable product. The entrance area of the capsule includes an entrance filter for supplying the fluid to the extractable product therethrough. The filter is a multi-layer filter including at least a first layer and a second layer bonded together. The first layer has a higher tear strength than the second layer and the second layer has a higher stiffness than the first layer.
US08906430B2 Use of hypericum perforatum extracts in the treatment of neuropathic pain
Disclosed is the use of hypericum (Hypericum perforatum L.) tip extracts containing hypericin, of hypericin, to prepare medicinal products and/or food supplements for the treatment of neuropathic pain.
US08906429B1 Medical cannabis lozenges and compositions thereof
A method for optimizing the therapeutic effects provided by CBD on the one hand, and the psychotropic effects provided by THC on the other hand, in a sublingual medicament, the method includes the steps of obtaining a concentrated extract of cannabis in which the concentration of CBD is known and the concentration of THC is known, formulating a hydrophilic mixture containing ingredients such as sugar, corn syrup, xylitol, purified water, organic flavorings, coconut oil, and concentrated extract of cannabis, wherein the amount of CBD is as high as possible and where the amount of THC is precisely controlled, forming lozenges, and administering the medicament.
US08906425B2 Stimulation of the synthesis of the activity of an isoform of lysyl oxidase-like LOXL for stimulating the formation of elastic fibers
The invention relates to the stimulation of the synthesis and of the activity of an isoform of lysyl oxidase, and more particularly of the LOXL (lysyl oxidase-like) isoform. The invention relates notably to a method of identifying an active principle which stimulates the formation of elastic fibers. The aim of the invention is mainly to provide such a method of identification so as to provide compositions which enable stimulating the formation of elastic fibers.
US08906423B2 Topical phytotherapeutic compound for the treatment of herpes based on Uncaria tomentosa and extraction process for obtaining a vegetal extract from Uncaria tomentosa
The present invention concerns a phytotherapic compound for the treatment of herpes based on Uncaria tomentosa characterized by the presence of: (a) A therapeutically efficient amount of an Herbal Extract from Uncaria tomentosa (Willd) DC Rubiaceae, (b) a pharmaceutically acceptable vehicle, (c) at least one pharmaceutically acceptable excipient, and, (d) optionally, pharmaceutically acceptable adjuvants. It also concerns a process of extraction for obtaining the Herbal Extract from Uncaria tomentosa (Willd) DC Rubiaceae, active ingredient of the phytotherapic compound for the treatment of herpes of the present invention.
US08906422B2 Method for inhibiting cancer using arsenic trioxide
The invention provides a method for treating cancers that are dependent on cyclin D1 for proliferation, survival, metastasis and differentiation, involving administering a composition containing an effective amount of arsenic trioxide to an affected patient. The arsenic trioxide can be administered orally, for example, as a solution, suspension, syrup, emulsion, tablet, or capsule. The composition can also contain one or more pharmaceutically acceptable carriers and/or excipients.
US08906420B2 Pharmaceutical formulation comprising one or more fumaric acid esters in an erosion matrix
A pharmaceutical formulation comprising an erosion matrix comprising one or more fumaric acid esters as well as one or more rate-controlling agents, wherein erosion of said erosion matrix permits controlled release of said fumaric acid ester(s).
US08906418B1 Thermal treatment of a pilosebaceous unit with nanoparticles with coatings that facilitate selective removal from the skin surface
Treatment of skin tissue with photoactive materials and light, such as nanoparticles and formulations which are useful for cosmetic, diagnostic and therapeutic applications to mammals such as humans. In particular, embodiments of thermal treatment of a pilosebaceous unit with nanoparticles with coatings that facilitate selective removal from the skin surface are disclosed.
US08906417B2 Nanostructures for drug delivery
The present invention provides compositions, preparations, formulations, kits, and methods useful for treating subjects having cancer or at risk of developing cancer. Some embodiments of the invention may comprise a composition comprising a plurality of particles comprising a platinum(IV) therapeutically active precursor.
US08906413B2 Drug formulations having reduced abuse potential
Drug formulations having reduced abuse potential which contain one or more of (1) a bittering agent, (2) a bright deterrent/indicator dye and (3) fine insoluble particulate matter. The bittering agent and dye are in a form which does not affect proper administration of the drug, but the bittering agent creates a bitter side effect when the dosage form is crushed or chemically extracted and nasally, orally, buccally or sublingually administered and the dye produces a bright color when crushed and contacted. The fine insoluble particulate matter hinders extraction of the drug from the dosage form and, when crushed, can deter intravenous injection because of the presence of the insoluble particles or hinder injection by blocking an intravenous needle. The bright color of the dye, when extracted, also has a psychologically deterrent effect on intravenous abusers.
US08906412B2 GABA analog prodrug sustained release oral dosage forms
Sustained release oral dosage forms of a gabapentin prodrug, 1-{[(α-isobutanoyloxyethoxy)carbonyl]aminomethyl}-1-cyclohexane acetic acid, are disclosed. The dosage forms are useful for treating or preventing diseases and disorders for which gabapentin is therapeutically effective.
US08906402B2 System and method for attaching soft tissue to an implant
One embodiment of the present invention is directed to compositions and methods for enhancing attachment of soft tissues to a metal prosthetic device. In one embodiment a construct is provided comprising a metal implant having a porous metal region, wherein said porous region exhibits a nano-textured surface.
US08906400B2 Insecticidal polymer matrix comprising PBO and DM
An insecticidal polymer matrix containing Piperonyl Butoxide (PBO) and deltamethrin (DM), wherein the ratio between the content of PBO and the content of DM in terms of weight is higher than 3.
US08906399B2 Preparation containing at least one type of fungicidal conazole
The invention relates to preparations, in particular plant-protective preparations which contain a mixture of at least two different active plant-protective substances, wherein a) at least one active substance is selected from a conazole group (active substance 1) and b) another active-plant protective substance (active substance 2) whose water solubility at a temperature of 20° C. is less than 20 g/l., c) at least one type of copolymer CP consisting of M monomers comprising α) at least one type of monoethylenically unsaturated monomer M1 comprising at least one sulphonic acid group and β) at least one type of neutral monoethylenically unsaturated monomer M2, wherein the quantitative ratio between the active substance 1 and the other active plant-protective substance 2 ranges from 1:10 to 10:1. Said invention also relates to novel copolymers CP which are embodied in the form of polymers consisting of at least three types of different monoethylenically unsaturated monomers M and comprise, in the polymerization incorporated form, α) at least one type of monoethylenically unsaturated monomer M1 comprising at least one sulphonic acid group, β1) at least one type of neutral monoethylenically unsaturated monomer M2 whose water solubility at a temperature of 20° C. is less than 30 g/l and β2) at least one type of neutral monoethylenically unsaturated monomer M2b whose water solubility at a temperature of 20° C. is greater than 50 g/l.
US08906398B2 Insecticide-containing netlike fabric
The present invention relates to an insecticide-containing fabric containing at least one embedded insecticidally active ingredient in the polymeric matrix and having excellent wash resistance, and also to the products produced from this fabric and to their use for protecting humans, animals and plants against arthropods, particularly for controlling insects.
US08906397B2 Permeation enhancers for topical formulations
A composition to be used as a permeation enhancer is provided. The composition may be added to topical cosmetics or pharmaceutical formulations that are topically applied. The composition comprises about 10-50% of Pracaxi oil, 15-40% of Patauá oil, 10-30% of Inaja oil, and 10-30% of one of more emollients.
US08906396B2 High-loading, controlled-release magnesium oral dosage forms and methods for making and using same
Disclosed are high loading, controlled-release dosage forms for oral administration of magnesium salts. For example, an oral dosage form can comprise from about 80% to about 95% magnesium lactate and one or more components. As another example, an oral dosage form can comprise at least about 50% magnesium salt and exhibit a controlled release dissolution profile. Also disclosed are methods for making controlled release dosage forms for oral administration of a therapeutically effective amount of magnesium salt to a mammal. Also disclosed are methods for treating a disorder characterized by magnesium deficiency and methods for preventing or alleviating low magnesium levels.
US08906395B2 Pharmaceutical composition in which solubility of partially soluble tricyclic derivative is improved
A pharmaceutical composition includes lipid nanoparticles which include two or more of a phospholipid, cholesterol, and an ionic lipid, and a tricyclic derivative, wherein the solubility of the tricyclic derivative is improved. It is possible to solubilize a partially soluble tricyclic derivative in a high concentration even without using a solubilization aid harmful to the human body, to maintain improved solubility even if water is added for the use as an injection, and to show stability even if stored for a long time, by preparing lipid nanoparticles. Therefore, the lipid nanoparticles of the present invention can be used for preparing a pharmaceutical preparation containing a partially soluble tricyclic derivative as an active ingredient.
US08906394B2 Hyaluronic acid based copolymers
Hyaluronic acid (HA) conjugates or crosslinked HAs compositions for coating an implantable device are provided. The implantable device can be used for treating a disorder such as atherosclerosis, thrombosis, restenosis, high cholesterol, hemorrhage, vascular dissection or perforation, vascular aneurysm, vulnerable plaque, chronic total occlusion, claudication, anastomotic proliferation for vein and artificial grafts, bile duct obstruction, ureter obstruction, tumor obstruction, and combinations thereof.
US08906388B2 Methods for detecting Mycobacterium tuberculosis antigens
Method for detecting M. tuberculosis antigens, comprising: a) contacting a sample of a biological fluid with a solid support; b) adding an amount of a first antibody against at least one M. tuberculosis protein; c) screening for the presence of M. tuberculosis proteins in the biological fluid by adding an amount of a second antibody which binds to the first antibody, in a Miniblotter device.
US08906386B2 Mutant proteins of the F protein of PIV-5 and PIV-2
The present application concerns mutant proteins of the fusion protein (F protein) of the parainfluenza virus (PIV) which are currently indexed as type 5 PIV (PIV-5 or PIV5) and type 2 PIV (PIV-2 or PIV2). The present application concerns products deriving therefrom, such as: nucleic acids, vectors, cells, fusion inhibitors of the antibody, aptamer, interfering RNA type; myelomas, hybridomas; stem and progenitor cells. The present application also concerns mutant proteins and products derived therefrom for use in medical and biotechnological applications.
US08906383B2 T cell receptor having binding affinity for a peptide-MHC complex and uses thereof
The present disclosure provides isolated preproinsulin-derived peptides of 8 or 9 amino acids, comprising the amino acid sequence WGPDPAA (SEQ ID NO: 1), isolated Class I peptide-HLA complexes presenting said peptides and isolated molecules having binding affinity for said peptides and/or said peptide-HLA complexes. Such compositions are useful in the treatment of type 1 diabetes mellitus (T1DM). Such isolated molecules can include a T cell receptor (TCR) having specific binding affinity for a peptide-MHC complex wherein the MHC is an HLA Class I molecule and the peptide is a preproinsulin-derived peptide of 8 to 10 amino acids, comprising the amino acid sequence WGPDPAA (SEQ ID NO: 1).
US08906377B2 Stably tethered structures of defined compositions with multiple functions or binding specificities
The present invention concerns methods and compositions for stably tethered structures of defined compositions with multiple functionalities and/or binding specificities. Particular embodiments concern stably tethered structures comprising a homodimer of a first monomer, comprising a dimerization and docking domain attached to a first precursor, and a second monomer comprising an anchoring domain attached to a second precursor. The first and second precursors may be virtually any molecule or structure, such as antibodies, antibody fragments, antibody analogs or mimetics, aptamers, binding peptides, fragments of binding proteins, known ligands for proteins or other molecules, enzymes, detectable labels or tags, therapeutic agents, toxins, pharmaceuticals, cytokines, interleukins, interferons, radioisotopes, proteins, peptides, peptide mimetics, polynucleotides, RNAi, oligosaccharides, natural or synthetic polymeric substances, nanoparticles, quantum dots, organic or inorganic compounds, etc. The disclosed methods and compositions provide a simple, easy to purify way to obtain any binary compound attached to any monomeric compound, or any trinary compound.
US08906374B2 Combination therapy with CD4 lymphocyte depletion and mTOR inhibitors
The invention provides methods for treating a malignant neoplastic cell proliferative disorder or disease, comprising administering to a subject in need thereof an effective amount of an mTOR inhibitor and an effective amount of a CD4 lymphocyte depleting agent. Such methods find utility in the treatment of certain subsets of malignant neoplastic cell proliferative disorders or diseases, e.g. renal cell carcinoma and melanoma. The invention also provides for pharmaceutical compositions comprising a therapeutically effective amount of an mTOR inhibitor and an effective amount of a CD4 lymphocyte depleting agent in a pharmaceutically acceptable carrier.
US08906370B2 Antibodies against amyloid beta 4 with glycosylation in the variable region
The present invention relates to a purified antibody molecule preparation being characterized in that at least one antigen binding site comprises a glycosylated asparagine (Asn) in the variable region of the heavy chain (VH). More specifically, a pharmaceutical and a diagnostic composition comprising said antibody molecule and antibody mixtures are provided which is/are capable of specifically recognizing the β-A4 peptide/Aβ4. The present invention relates in particular to a mixture of antibodies comprising one or two glycosylated antigen binding sites with a glycosylated asparagine (Asn) in the variable region of the heavy chain, i.e. mixtures of isoforms of antibodies which comprise a glycosylated Asn in the variable region of the heavy chain (VH). Also disclosed are compositions or antibody preparations comprising the specifically glycosylated antibody isoforms. Furthermore, the pharmaceutical and diagnostic uses for these antibodies are provided. The antibody isoforms may for example be used in the pharmaceutical intervention of amyloidogenesis or amyloid-plaque formation and/or in the diagnosis of the same.
US08906369B2 Ovr110 antibody compositions and methods of use
Isolated antibodies and antigen binding fragments thereof directed against Ovr110 which is expressed by head and neck, ovarian, endometrial, kidney, pancreatic, lung or breast cancer are provided. Also provided are cells and methods for their production as well as methods for their use in killing an Ovr110-expressing cancer cells and alleviating or treating an Ovr110-expressing cancer in a mammal. The anti-Ovr110 antibodies modulate Ovr110 function or internalize upon binding to Ovr110 expressed by mammalian cells in vitro and in vivo. Compositions comprising an anti-Ovr110 antibody and a carrier as well as articles of manufacture or kits thereof are also provided. In addition, isolated nucleic acids encoding an anti-Ovr110 antibody, expression vectors containing the isolated nucleic acids, and host cells containing the vectors are provided.
US08906367B2 Method of providing disease-specific binding molecules and targets
Provided are novel specific binding molecules, particularly human antibodies as well as fragments, derivatives and variants thereof that recognize neoepitopes of disease-associated proteins which derive from native endogenous proteins but are prevalent in the body of a patient in a variant form and/or out of their normal physiological context. In addition, pharmaceutical compositions comprising such binding molecules, antibodies and mimics thereof and methods of screening for novel binding molecules, which may or may not be antibodies as well as targets in the treatment of neurological disorders such as Alzheimer's disease are described.
US08906365B2 Antimicrobial agents
The application relates to antimicrobial agents against Gram-negative bacteria, in particular to fusion proteins composed of an enzyme having the activity of degrading the cell wall of Gram-negative bacteria and a peptide stretch fused to the enzyme at the N- or C-terminus, as well as pharmaceutical compositions thereof. Moreover, it relates to nucleic acid molecules encoding such a fusion protein, vectors carrying the nucleic acid molecules and host cells transformed with either the nucleic acid molecules or the vectors. In addition, it relates to such a fusion protein for use as a medicament, in particular for the treatment or prevention of Gram-negative bacterial infections, as diagnostic means or as cosmetic substance. The application also relates to the treatment or prevention of Gram-negative bacterial contamination of foodstuff, of food processing equipment, of food processing plants, of surfaces coming into contact with foodstuff, of medical devices, of surfaces in hospitals and surgeries.
US08906360B2 Light-activated cation channel and uses thereof
The present invention provides compositions and methods for light-activated cation channel proteins and their uses within cell membranes and subcellular regions. The invention provides for proteins, nucleic acids, vectors and methods for genetically targeted expression of light-activated cation channels to specific cells or defined cell populations. In particular the invention provides millisecond-timescale temporal control of cation channels using moderate light intensities in cells, cell lines, transgenic animals, and humans. The invention provides for optically generating electrical spikes in nerve cells and other excitable cells useful for driving neuronal networks, drug screening, and therapy.
US08906355B2 Synthetic stereoisomer peptides in the retro-inverso and inverso configuration, and with cyclic and linear structure, their polymer conjugates, their encapsulation in polymer particles, and uses thereof
This invention discloses ligand-targeted multi-stereoisomer peptide-polymer conjugate compounds comprising a plurality of different synthetic and chemically modified stereoisomer peptides that have been conjugated to a biocompatible polymer carrying a peptide ligand for targeted delivery or encapsulated in ligand targeted polymer nanoparticles. The unique physicochemical properties of the stereoisomer peptides provide therapeutic compounds with ideal biopharmaceutical properties. The stereoisomer peptides carried by the polymer are delivered to cells or tissues to inhibit, suppress, block, or disrupt, simultaneously and independently, the functional domain of a different disease causing protein. Therefore the compounds are useful therapeutics for the treatment of abnormal angiogenesis and inflammation which are the hall mark of most human diseases including but not limited to cancer, metastasis, pathological conditions of the eye, cardiovascular, brain, and neurodegenerative disorders, diabetes, and diseases caused by infectious microorganisms.
US08906353B2 Compositions and methods for achieving sustained therapeutic drug concentrations in a subject
Provided herein are compounds and methods for achieving a sustained therapeutic effect of small molecule anti-cancer agents when administered in vivo.
US08906342B2 Compositions against cancer antigen LIV-1 and uses thereof
Described herein are methods and compositions that can be used for diagnosis and treatment of cancer.
US08906341B2 Hydrogen storage method, hydrogen generating method, hydrogen storage apparatus and hydrogen generating apparatus
Disclosed is a method for storing hydrogen, a method for generating hydrogen, a hydrogen storing device, and a hydrogen generating device. In a disclosed method for storing hydrogen, water that is treated so as to include hydrogen ions in a state the ions can be changed into protium is prepared, and hydrogen is stored by supplying a hydrogen-containing substance or a substance that generates hydrogen, for example, Mg, into the water. Preferably, the hydrogen-containing substance is sodium borohydride (NaBH4). Preferably, the water is ionized hydrogen water treated with a metal hydride, and the metal hydride is at least one among an alkali metal, an alkaline earth metal, a group 13 metal, and a group 14 metal.
US08906340B2 Purification of TiCl4 through the production of new co-products
The present disclosure relates to reacting tin metal with crude TiCl4 containing arsenic to produce pure TiCl4, SnCl4, and an arsenic solid co-product. In some embodiments, the contaminant vanadium is removed as well. The reaction is preferably done in a continuous fashion in two stages for maximum through-put and utility at an elevated temperature. Distillation can be used to purify the TiCl4 produced and simultaneously yield a purified SnCl4 product. The synthesis of SnCl4 in this method utilizes waste chloride to save virgin chlorine which would otherwise be used.
US08906339B2 High modulus graphitized carbon fiber and method for fabricating the same
The invention provides a high module carbon fiber and a fabrication method thereof. The high module carbon fiber includes the product fabricated by the following steps: subjecting a pre-oxidized carbon fiber to a microwave assisted graphitization process, wherein the pre-oxidized carbon fiber is heated to a graphitization temperature of 1000-3000° C. for 1-30 min. Further, the high module carbon fiber has a tensile strength of between 2.0-6.5 GPa and a module of between 200-650 GPa.
US08906338B2 Method for making carbon nanotube film
A method for making a carbon nanotube film is provided. In the method, a carbon nanotube array is grown on a substrate, and a rigid drawing device is provided. The carbon nanotube array is adhered to the rigid drawing device via an planar adhesive region of the rigid drawing device. The rigid drawing device is pulled at a speed along a direction away from the substrate, thereby pulling out a continuous carbon nanotube film. The carbon nanotube array includes a plurality of carbon nanotubes. The planar adhesive region have a linear border, wherein the linear border of the planar adhesive region is the closest border of the planar adhesive region to a surface of the substrate. The carbon nanotubes in the carbon nanotube array are adhered via the planar adhesive region.
US08906331B2 Nitric oxide oxidation over silver-based catalysts
Ag/Al2O3 materials may be packaged in a suitable flow-through reactor, close coupled to the exhaust manifold of a diesel engine, and upstream of other exhaust gas treatment devices, such as a diesel oxidation catalyst and a selective reduction catalyst for NOx. The silver/alumina catalyst material uses hydrogen in a cold-start engine exhaust and serves to oxidize NO to NO2 in the relatively low temperature, hydrocarbon-containing, exhaust during a short period following the engine cold start, and to temporarily store NOx during the start-up period. After the exhaust has heated downstream catalytic devices, the silver yields its nitrogen oxides for conversion to nitrogen by the then-operating devices before NOx is discharged to the atmosphere.
US08906329B2 Zeolite catalyst containing metal
A catalyst composition is provided having a zeolite material of a CHA crystal structure and a silica to alumina mole ratio (SAR) of about 10 to about 25 and preferably having a mean crystal size of at least 1.0 microns; and a non-aluminum base metal (M), wherein said zeolite material contains said base metal in a base metal to aluminum ratio (M:Al) of about 0.10 to about 0.24.
US08906328B2 Heap leaching of manganese-containing ores
A method for the heap leaching of manganese-containing ores, the method characterized by the steps of: (i) beneficiating the manganese-containing ore and separating into a coarse fraction and a fine ore fraction; (ii) combining the fine ore fraction with a sulfide ore material to produce a combined ore fraction; (iii) stacking the combined ore fraction to form at least one heap; and (iv) applying a lixiviant to the heap to produce a pregnant leach solution (PLS) containing dissolved manganese values, wherein the lixiviant is added to the or each heap in the presence of soluble iron.
US08906326B2 Biochemical reaction cassette
A biochemical reaction cassette having a structure for uniformizing a liquid flow in a reaction chamber with a simple additional arrangement is provided. A fluid resistive section is arranged in a channel that is constructed to include an injection port, a reaction chamber, and a discharge port. The fluid resistive section decreases the cross-sectional area of the channel to decrease the fluid resistance at ends in the width direction of the fluid resistive section and at positions remote from the injection port and the discharge port, where the flow rate is decreased.
US08906322B2 Method for continuous particle separation using obstacle arrays asymmetrically aligned to fields
The present invention relates to methods and devices for separating particles according to size. More specifically, the present invention relates to a microfluidic method and device for the separation of particles according to size using an array comprising a network of gaps, wherein the field flux from each gap divides unequally into subsequent gaps. In one embodiment, the array comprises an ordered array of obstacles in a microfluidic channel, in which the obstacle array is asymmetric with respect to the direction of an applied field.
US08906321B2 Reagent kit with in-transit securing means
A reagent kit comprising: a reagent container assembly with at least one reagent container, wherein the reagent container has at least one container body and at least one closure which can be mounted or provided on the container body. The closure comprises a closure base member and a lid which is mounted movably on the base member for movement at least between a closed lid position and another lid position, and an in-transit securing means mountable in a locking position on the reagent container and which is movable relative to the reagent container from the locking position into a release position. The in-transit securing means, when in the locking position, secures the lid in the closed lid position. By moving the in-transit securing means from the locking position into the release position, the lid is moved from the closed lid position into the other lid position.
US08906312B2 Polyethylene manufacturing system and method
An ethylene polymerization system is provided with a quench system and that cools the product mixture entering the separation system with a reduced load on the first compressor of the system. The system includes first and second compressors, a high pressure reactor; a high pressure let down valve through which the product mixture from the high pressure reactor flows, and a separation system that separates gas from the product mixture. The quench system includes a pump having a suction inlet that receives all or substantially all of the low pressure flow of monomer from the first compressor. The system provides quenching of the product stream while allowing the first compressor to be operated at a discharge pressure lower than the suction pressure of the second compressor, thereby conserving energy.
US08906310B2 Test set for a photometric measuring device and photometric measuring method for a sample liquid
A test set for a photometric measuring device includes a mixing container which receives a first fluid in its interior and a closing element which is removable from its filling opening, and a dosing container which contains a second fluid in a sealed hollow chamber, with the hollow chamber being sealed on one side by a displaceable sealing plunger and on the opposite side by a movable plug, and with the dosing container being insertable in a sealing manner into the filling opening of the mixing container. For the purpose of simplifying the input of the sample, the dosing container includes an integrated sample-taking device which, after the insertion of the dosing container in the filling opening of the mixing container, is in contact with the first fluid present in the mixing container.
US08906307B2 Apparatus for providing power management in data communication systems
A blood glucose meter having a compact housing, a display unit disposed on the housing, the display unit including a display light source to illuminate the display unit, an input unit disposed on the housing, the input unit configured to provide input functions for the blood glucose meter, and a power source provided within the housing for providing power to the blood glucose meter, where the housing includes a port integrated on said housing configured to receive a blood glucose test strip, and corresponding methods of measuring blood glucose meter is provided.
US08906300B2 Even perfusion pump-integrated blood oxygenator
A blood oxygenator includes an integral pneumatic pump disposed substantially within a housing thereof, an inlet blood flow redirector, and an outflow blood collector. An atrium provided at an inlet of the oxygenator promotes even delivery of blood to the oxygenator. In use, the oxygenator provides an even dispersion of blood therethrough, establishing even perfusion and reducing areas of stagnant blood flow.
US08906297B1 Toothbrush sanitizer
The toothbrush sanitizer is a small device that can sanitize the head of a toothbrush, and includes a small steam chamber that is accessibly via sealed opening. The sealed opening is adjacent the small chamber and includes a rubber seal that opens upon entrance of a toothbrush head therein. A heating element is positioned between a water reservoir and the small chamber. The heating element is responsible for forming steam and directing said steam onto the toothbrush head located in the small steam chamber. The toothbrush sanitizer is powered by batteries or includes an electrical plug that extends from a rear surface to plug the device into an electrical outlet.
US08906295B2 Near-beta titanium alloy for high strength applications and methods for manufacturing the same
A high strength near-beta titanium alloy including, in weight %, 5.3 to 5.7% aluminum, 4.8 to 5.2% vanadium, 0.7 to 0.9% iron, 4.6 to 5.3% molybdenum, 2.0 to 2.5% chromium, and 0.12 to 0.16% oxygen with balance titanium and incidental impurities is provided. An aviation system component comprising the high strength near-beta titanium alloy, and a method for the manufacture of a titanium alloy for use in high strength, deep hardenability, and excellent ductility applications are also provided.
US08906294B2 Magnesium alloy material
A magnesium alloy material having excellent impact resistance is provided. The magnesium alloy material is composed of a magnesium alloy that contains more than 7.5% by mass of Al and has a Charpy impact value of 30 J/cm2 or more. Typically, the magnesium alloy material has an elongation of 10% or more at a tension speed of 10 m/s in a high-speed tensile test. The magnesium alloy is composed of a precipitate, typically made of an intermetallic compound containing at least one of Al and Mg, and contains particles having an average particle size of 0.05 μM or more and 1 μm or less dispersed therein. The total area of the particles accounts for 1% by area or more and 20% by area or less. The magnesium alloy material containing fine precipitate particles dispersed therein has high impact absorption capacity through dispersion strengthening and has excellent impact resistance.
US08906293B2 Magnesium alloy
An object of the invention is to provide a magnesium alloy having high strength and sufficient formability. A magnesium alloy mainly contains magnesium and has high tensile strength and high compression strength. The crystal grain structure of the alloy has a high angle grain boundary, and the inside of the crystal grain surrounded by the high angle grain boundary is composed of subgrains.
US08906282B2 Micro-structured and nano-structured surfaces on biodegradable polymers
In embodiments of the present invention, a biodegradable/biodegradable polymer film may be used as a scaffold for tissue engineering scaffolds for engineering organized organs, such as vascular grafts, for example. In one embodiment, an ultraviolet (UV) resin made from a diacrylated biodegradable oligomer is molded into a flexible scaffold having cavities and/or channels. Channel/cavity size may be on the order of micrometers and/or nanometers, and thus the walls may have high aspect ratios. Smooth muscle cells may be deposited in the channels and because of the high aspect ratios, the cells may align along the channels/cavities as confluence is reached.
US08906278B2 Process of melt-spinning polyacrylonitrile fiber
Processes for producing carbon fiber, the filament thereof and pre-oxidized fiber are provided. In one embodiment, the gel spinning of polyacrylonitrile filament is achieved by using small-molecule gelling agent, and the carbon fiber obtained thereby is increased by 15% to 40% in tensile strength and by 20% to 35% in toughness. In another embodiment, the melt spinning process of polyacrylonitrile is conducted by using imidazole type ion liquid as plasticizer, the process reduces environment pollution, is suitable for industrial production and the fiber produced thereby is improved in its strength. In yet another embodiment, polyacrylonitrile pre-oxidized fiber is produced by melt spinning, so low cost and controllable pre-oxidization of polyacrylonitrile can be achieved. In a further embodiment, high strength carbon fiber is manufactured by using polymer thickening agent. In another further embodiment, low cost and controllable pre-oxidization of polyacrylonitrile is achieved by conducting pre-oxidization before spinning, minimizing skin-core structure, so as to produce high performance carbon fiber, and reduce the production cost of carbon fiber greatly.
US08906272B2 Infra-red reflective material and production method thereof, and paint and resin composition containing the same
An infra-red reflective material is a perovskite-like multiple oxide which includes at least an alkaline-earth metal and at least one type of element selected from a group of titanium, zirconium and niobium, and further, if necessary, manganese and/or iron, an element belonging to the IIIa group of the periodic table such as aluminum and gallium, etc., or zinc, etc., has sufficient infra-red reflective power, is excellent in thermal stability and heat resistance, and does not raise concerns on safety and environmental issues. The infra-red reflective material can be produced by, for example, mixing an alkaline-earth metal compound and a titanium compound and further, if necessary, a manganese compound and/or an iron compound, a compound belonging to the IIIa group of the periodic table, or a zinc compound in predetermined amounts, and firing the mixture. The produced multiple oxide is powdery and can be mixed with paint or a resin composition so as to be used for various purposes such as painting a roof or an outside wall of a building, a road, or a foot path in order to reduce the heat island phenomenon.
US08906267B2 Compositions of vapour phase corrosion inhibitors, method for the production thereof and use thereof for temporary protection against corrosion
The invention relates to substance combinations comprising (1) at least one substituted, preferably polysubstituted, pyrimidine, (2) at least one monoalkylurea, (3) at least one C3 to C5 aminoalkyldiol, and optionally (4) at least one benzotriazole, preferably a benzotriazole which is substituted on the benzene ring. The components may be mixed together or dispersed in water or pre-mixed in a solubiliser that is miscible in any ratio with mineral oils and synthetic oils, such as for example a phenyl alkyl alcohol or an alkylated phenol. Such substance combinations can be used as vapour phase corrosion inhibitors in packagings or during storage in closed spaces for protecting customary utility metals, such as iron, chromium, nickel, tin, zinc, aluminium, copper and alloys thereof, against atmospheric corrosion.
US08906260B2 Difluoroethyleneoxi derivatives, the liquid crystal composition and the liquid crystal display device
To provide a liquid crystal compound showing a large absolute value of dielectric anisotropy (|Δ∈|. A compound is represented by formula (1): wherein, in formula (1), Ra and Rb are fluorine, alkyl having 1 to 10 carbons or the like, and in the alkyl, at least one of —CH2— may be replaced by —O— or the like, however, Ra and Rb are not identical; A1, A2, A3, A4 and A5 are 1,4-cyclohexylene, 1,4-phenylene or the like, and in the groups, at least one of hydrogen may be replaced by fluorine; Z1, Z2, Z4 and Z5 are a single bond or the like; Y1, Y2, Y3 and Y4 are hydrogen, fluorine or the like; and m, n, q and r are 0, 1 or 2, and a sum of m, n, q and r is 0, 1, 2, 3 or 4.
US08906259B2 Naphthenic-rich liquid crystalline polymer composition with improved flammability performance
A thermoplastic composition that comprises a naphthenic-rich, thermotropic liquid crystalline polymer blended with a flow modifier is provided. The flow modifier is an aromatic carboxylic acid that contains or more carboxyl functional groups. Without intending to be limited by theory, it is believed that the functional groups can react with the polymer chain to shorten its length and thus reduce melt viscosity. It is also believed that such acids can combine smaller chains of the polymer together after they have been cut during processing. This helps maintain the mechanical properties of the composition even after its melt viscosity has been reduced. As a result of the present invention, the melt viscosity of the thermoplastic composition is generally low enough so that it can readily flow into the cavity of a mold having small dimensions.
US08906258B2 Heat-resistant liquid crystalline polymer composition having a low melting temperature
A thermotropic liquid crystalline polymer composition capable of exhibiting both a low melting temperature and good heat resistance without the use of conventional naphthenic acids is provided. The melting temperature may, for example, range from about 250° C. to about 400° C. Even at such low melting temperatures, the present inventors have surprisingly discovered that the ratio of the deflection temperature under load (“DTUL”), a measure of short term heat resistance, to the melting temperature may remain relatively high. The specific DTUL values may range from about 200° C. to about 300° C. The ability to form a polymer composition with the properties noted above may be achieved, at least in part, by the use of an aromatic amide oligomer.
US08906256B2 Nanometal dispersion and method for preparing the same
A nanometal dispersion and a method for preparing a nanometal dispersion are provided. The method comprises mixing a metal seed crystal aqueous solution, a polysaccharide aqueous solution, and a metal compound aqueous solution, followed by allowing the resulting mixture to conduct a reduction-oxidation reaction to form a nanometal. The produced nanometal dispersion comprises a polysaccharide and a nanometal. The polysaccharide is composed of N-actyl-D-glucosamine and glucuronic acid, and the nanometal has multimorphology.
US08906252B1 CMP compositions selective for oxide and nitride with high removal rate and low defectivity
The invention provides a chemical-mechanical polishing composition containing a ceria abrasive, an ionic polymer of formula I: wherein X1 and X2, Z1 and Z2, R2, R3, and R4, and n are as defined herein, and water, wherein the polishing composition has a pH of about 1 to about 4.5. The invention further provides a method of chemically-mechanically polishing a substrate with the inventive chemical-mechanical polishing composition. Typically, the substrate contains silicon oxide, silicon nitride, and/or polysilicon.
US08906251B2 Environmentally benign anti-icing or deicing fluids
Deicing compositions comprised of glycerol-containing by-products of triglyceride processing processes are disclosed.
US08906236B2 Process for the recovery of oleaginous compounds and nutrients from biomass
Disclosed herein are methods and processes for the recovery of nutrients from non-organic phases produced during recovery of oleaginous compounds from biomass. The nutrients recovered can then be utilized to grow additional biomass.
US08906234B2 Filter device
A filter device of the present disclosure includes a first port from which a solution containing a substance is to be input, and a first flow passage communicating with the first port. A filter portion made of a plurality of fibrous substances including inorganic oxide is formed in at least one part in the first flow passage. The plurality of fibrous substances has one peak in the diameter distribution.
US08906232B2 Deformable sump insert
A flexible, water-permeable filter basket may be used to collect and remove debris from a sump in a drain-entry structure (e.g., a catch-basin). The filter basket includes a basket floor having a perimeter of substantially the same size and shape as a sump floor, at least one basket sidewall corresponding to at least one sump sidewall, and one or more handles collectively affixed to the at least one basket sidewall, the at least one basket sidewall collectively including a resilient frame. The filter basket may be used as a deformable sump insert to collect debris falling into a drain-entry structure for removal without use of a vactor truck.
US08906228B2 Process, method, and system for removing heavy metals from fluids
Trace amount levels of heavy metals such as mercury in crude oil are reduced by contacting the crude oil with an oxidizing agent and then with a reducing agent. In one embodiment, the oxidizing agent is selected from the group of hydroperoxides, organic peroxides, inorganic peracids and salts thereof, organic peracids and salts thereof, halogens such as iodine (I2), bromine (Br2), and ozone. The treatment converts non-volatile mercury in the crude oil into a volatile form for subsequent mercury removal by any of stripping, scrubbing, adsorption, and combinations thereof. In one embodiment, at least 50% of the mercury is removed. In another embodiment, the removal rate is at least 99%.
US08906222B2 Management method for wax fraction storage tank
The present invention relates to a management method for a wax fraction storage tank that stores a wax fraction produced by Fischer-Tropsch synthesis until the wax fraction is hydrocracked, the management method including maintaining the temperature inside the tank at 90° C. to 130° C. and maintaining the atmosphere inside the tank to be an inert gas atmosphere.
US08906217B2 Composite coatings for whisker reduction
There is provided a method and composition for applying a wear resistant composite coating onto a metal surface of an electrical component. The method comprises contacting the metal surface with an electrolytic plating composition comprising (a) a source of tin ions and (b) non-metallic particles, and applying an external source of electrons to the electrolytic plating composition to thereby electrolytically deposit the composite coating onto the metal surface, wherein the composite coating comprises tin metal and the non-metallic particles.
US08906213B2 NOx sensor control apparatus
In a NOx sensor control apparatus (1), a NOx sensor includes a heater (164), and an oxygen concentration detection cell (130), a first pumping cell (110) and a second pumping cell (120) which are arranged sequentially in the axis O direction. The NOx sensor control apparatus 1 includes a first impedance detection means (59a, 60) which detects the first impedance of the first cell (oxygen concentration detection cell), a heater control means (60) which performs an energization control of a heater such that the first impedance becomes a target value, a second impedance detection means (59b, 60) which detects the second impedance of the second cell (second pumping cell), and an output correction means (60) which corrects an output of at least the third cell (first pumping cell) based on the deviation between the first impedance and the second impedance.
US08906212B2 Method for evaluating corrosion resistance of cans to contents
A method to evaluate the corrosion resistance of a can to a content includes filling the can with the content to form a specimen, setting the specimen in an apparatus capable of blocking an outside atmosphere from entering the specimen, optionally saturating the content with nitrogen gas to expel dissolved oxygen present in the content, thereafter while maintaining the temperature of the content at a constant temperature in the range of 25 to 60° C., applying a constant potential that is more anodic than an immersion potential by 50 mV to 200 mV to the can of the specimen, and evaluating the corrosion resistance of the can to the content based on the accumulated amount of electricity generated during a time appropriately selected from 6 to 48 hours immediately after the application of the constant potential.
US08906210B2 Flux limiting membrane for intravenous amperometric biosensor
A flux limiting layer for an intravenous amperometric biosensor is formed on a substrate to limit a diffusion rate of an analyte from blood to an enzyme electrode. The layer may be formed from ethylene vinylacetate (EVA) dissolved in a solvent such as paraxylene, spray-coated to cover a portion of the electrode, and cured to seal the electrode to the substrate. In a glucose sensor having glucose oxidase disposed on the electrode, thickness and concentration of the EVA layer are optimized to promote a linear output of electrode current as a function of blood glucose concentration.
US08906203B2 Method for the desalination or purification of water by distillation of a spray (spray pump)
A system enables the use of solar heat energy together with electromagnetic energy and optionally energy produced during fermentation of organic products to produce fresh water from salt water, wastewater and water vapor contained in the atmosphere. The resulting fresh water can optionally be rendered drinkable by adding mineral salts at the desired concentration. A method and reactors combine electromagnetic and solar heating steps and optionally heat exchanges with a hot gas originating from combustion, to evaporate droplets of a spray produced from salt water or wastewater. The vapor obtained is separated from the salt particles or agglomerated impurities during evaporation using a cyclone system. The vapor can then be transported over a large distance before being condensed by bearings, in order to separate the water from any additives or impurities that may be present. Additives can be used to lower the vapor pressure of the liquid water and to facilitate droplet fractionation.
US08906202B2 Method of detecting and reducing contamination in papermaking boiler systems
This invention relates to a method and system for detecting contamination of boiler condensate and/or boiler feedwater in a papermaking process. The method includes measuring an oxidation-reduction potential at one or more locations in the boiler condensate and/or the boiler feedwater of the papermaking process with one or more corrosion stress monitoring devices. A controller is operable to assess whether the measured or a calculated oxidation-reduction potential is within an optimum range. The controller is operable to cause transmission of a signal to direct feeding an effective amount of one or more reductants and/or one or more pH-controlling chemicals into the boiler feedwater and/or one or more a satellite feed locations of the papermaking process.
US08906200B2 Processes to produce short cut microfibers
A process for producing a microfiber product stream, the process comprising: (A) contacting cut multicomponent fibers having a length of less than 25 millimeters with a treated aqueous stream in a fiber slurry zone to produce a cut multicomponent fiber slurry; (B) contacting the cut multicomponent fiber slurry with a heated aqueous stream in a mix zone to produce a heated multicomponent fiber slurry; (C) routing the heated multicomponent fiber slurry to a fiber opening zone to remove a portion of the water dispersible sulfopolyester to produce an opened microfiber slurry; and (D) routing the opened microfiber slurry to a primary solid liquid separation zone to produce the microfiber product stream and a first mother liquor stream.
US08906193B2 Gas supply unit, substrate processing apparatus and supply gas setting method
A gas supply unit, for supplying a gas into a processing chamber in which a substrate is processed, includes a plurality of gas supply sources, a mixing line for mixing a plurality of gases supplied from the gas supply sources to make a gaseous mixture, a multiplicity of branch lines for branching the gaseous mixture to be supplied to a multiplicity of places in the processing chamber, and an additional gas supply unit for supplying a specified additional gas to a gaseous mixture flowing in at least one branch line. The gas supply unit also includes pressure gauges and valves for adjusting gas flow rates in the branch lines, respectively, and a pressure ratio controller for controlling that gaseous mixtures branched into the branch lines to have a specified pressure ratio by adjusting opening degrees of the valves based on measurement results obtained by using the pressure gauges.
US08906191B2 Method for making protective device for protecting carbon nanotube film
A method for making a protective device for protecting at least one carbon nanotube film is disclosed. At least one carbon nanotube film is pulled or drawn out from at least one carbon nanotube array. The carbon nanotube film has a first end connected to the carbon nanotube array and a second end opposite to the first end. A portion of the carbon nanotube film from the second end and a portion of a protecting film from one end are stacked on a portion of a base film along a length direction of the base film. Two rollers and a first spool are rotated so that the base film, the carbon nanotube film, and the protecting film pass through the two rollers while being pressed by the two rollers and rolled onto the first spool.
US08906190B2 Intermediate transfer belt steering rib applicator device and method
A system and apparatus are provided for adhering steering ribs to an intermediate transfer belt (ITB). These steering ribs (one or more) are applied to the ITB by placing the rib material around a cylindrical fixture. The rib material is held in place by a vacuum that is applied to the rib material to hold it against the fixture. An ITB may be separately held in place on the fixture by another vacuum until the rib material is adhered to the inside surface of the ITB through application of compressed air to force the rib material outward against the ITB. Once the rib material is adhered to the ITB, a series of apertures directs compressed air against the rib and the ITB to release them from the fixture.
US08906188B2 Fusion process for conduit
Disclosed is a method and apparatus for use in a fusion process for conduit. The method includes: heating and melting at least a portion of the terminal edges of the first conduit portion and the second conduit portion; and butt fusing the melted terminal edge of the first conduit portion with the melted terminal edge of the second conduit portion, thereby creating a fused joint area. A fusion apparatus for employing this method is also disclosed.
US08906182B1 Controlled porosity, transfer-coated fabrics
A method for preparing a composite fabric includes: casting a foamed liquid adhesive onto a smooth release-coated web; applying a fabric to the wet adhesive; fixing the adhesive to the fabric by drying; removing the release-coated web from the adhesive coated intermediate; depositing onto an embossed casting substrate a layer of liquid skin coat composition; applying the porous adhesive layer of the adhesive-coated intermediate to the wet skin layer; drying to fix the skin layer to the adhesive-coated intermediate; and separating the embossed casting substrate from the dried composite to provide the composite fabric. The resulting composite fabrics look and feel like soft shell composite fabrics.
US08906178B2 Optical fiber installation at customer premises
An optical fiber is permanently routed easily, quickly, and unobtrusively at a customer premises using an inventive hand tool, without staples or other fasteners. The fiber has an adhesive outer coating that is activated as the fiber is applied by the tool on an exposed surface such as a wall, ceiling, molding, groove, or corner at the premises. When the activated coating hardens, the fiber is bonded to the surface on which it was applied, and the hardened coating also provides physical protection for the fiber. In the disclosed embodiment, the coated fiber is supplied on a spool that mounts on the tool, and the coating is activated by guiding the fiber as it unwinds from the spool through a chamber containing an activating substance. The fiber with the activated coating is then guided to an applicator wheel on the tool which applies the fiber to the surface.
US08906176B2 Absorbent composite material and method for manufacturing the same
An absorbent composite comprising: a base material and water-absorbent resin particles; wherein the following conditions (1) to (4) are fulfilled: (1) the weight ratio of water-absorbent resin relative to the total weight of the base material and water-absorbent resin is 65 to 99 wt %, (2) the water-absorbent resin particles adhering directly to the base material constitute 50 wt % or more of the total water-absorbent resin particles; (3) the average absorption capacity of the water-absorbent resin particles is 50 g/g or more; and (4) the amount of residual monomers in the water-absorbent resin is 200 ppm or less.
US08906172B2 Amorphous alloy composite material and manufacturing method of the same
The present disclosure discloses an amorphous alloy composite material comprises an amorphous and continuous matrix phase, and a plurality of equiaxed crystalline phases as reinforcing phases dispersed in the matrix phase. Oxygen content in the amorphous alloy composite material may be less than 2100 ppm. The present disclosure also discloses a method of preparing the same. With the equiaxed crystalline phases dispersed in the matrix phase, the plasticity of the amorphous alloy composite material may be improved considerably.
US08906170B2 Alloy castings having protective layers and methods of making the same
An alloy casting having a protective layer disposed on a surface of the casting is provided. The protective layer is resistant to liquid metal attack, and wherein the protective layer includes an oxide of an element present in the alloy. A method of forming a protective layer on a surface of the alloy casting is also provided. The method includes disposing the alloy in a mold, and oxidizing an element of the alloy to form a protective layer on the surface of the casting.
US08906169B2 Devices for clearing blockages in in-situ artificial lumens
Devices and methods for the effective clearing of artificial tubes, especially in-situ clearing of artificial tubes in a living being are covered in this disclosure. An elongated clearing member includes either a fixed or an adjustable element that selectively defines the portion of the elongated clearing member that is insertable within the artificial tube. The proximal end of the clearing member is releasably secured to the driving mechanism and the driving mechanisms may comprise a wide variety of repetitive motion drivers such as voice coil motors, piezoelectric actuators, pneumatic actuators, DC motors, etc. These devices/methods may comprise a free-standing console for hands-free operation or may comprise hand-held versions. The distal working end of the clearing member may comprise tips of differing functions, including an irrigation/aspiration feature.
US08906168B2 Assisted-movement system for one of a rack and a door of an appliance
An assisted-movement system is provided for an appliance, such as a dishwasher including a tub portion defining a forward opening, a door pivotally engaged therewith for selectively engaging the forward opening, and a rack movable into and out of the tub portion through the forward opening. A biasing device is operably engaged between the tub portion and one of the door, via a hinge mechanism, and the rack. The biasing device is extendable between contracted and extended positions. A position control device is operably engaged between the tub portion and one of the door, the rack, and the biasing device, and is configured to cooperate with the one of the door, the rack, and the biasing device to at least one of maintain the door in a closed position and maintain the rack within the tub portion, with the biasing device in the contracted position. Associated dishwashers are also provided.
US08906163B2 Methods and apparatus for integrating and controlling a plasma processing system
A method of operating one or more back end circuits of a plasma processing system, comprising: prior to a front end module receiving one or more wafers to be processed, receiving preliminary data at a back end circuit, wherein the preliminary data indicates a recipe and a predetermined number, the predetermined number indicating a number of wafers to be processed; determining whether a plasma processing chamber is ready for processing; and if the chamber is ready for processing and via the back end circuit, selecting a load lock, based on the predetermined number, instructing the front end module to pull the one or more wafers into the load lock, enabling the chamber to process a first wafer of the one or more wafers according to the recipe, and subsequent to the processing of the first wafer, instructing the front end module to remove the first wafer from the chamber.
US08906161B2 Semiconductor producing device and semiconductor device producing method
A tubular electrode (215) and a tubular magnet (216) are installed on an external section of a processing furnace (202) for an MMT device. A susceptor (217) for holding a wafer (200) is installed inside a processing chamber (201) of the processing furnace. A gate valve (244) for conveying the wafer into and out of the processing chamber; and a shower head (236) for spraying processing gas in a shower onto the wafer, are installed inside the processing furnace. A high frequency electrode (2) and a heater (3) are installed inside the susceptor (217) with a clearance between them and the walls forming the space. The clearances formed between the walls forming the space in the susceptor and the high frequency electrode and the heater prevent damage to the high frequency electrode and the heater even if a thermal expansion differential occurs between the high frequency electrode, the heater and the susceptor.
US08906160B2 Vapor based processing system with purge mode
Embodiments of the present invention provide vapor deposition tools. In one example, a vapor deposition tool includes housing. A substrate support is positioned within the housing and configured to support a substrate. A backing plate is positioned above the substrate support. A showerhead is positioned between the substrate support and the backing plate and has a plurality of openings therethrough. A fluid trap member is positioned around a periphery of the showerhead. A fluid trap member actuator is coupled to the fluid trap member and configured to move the fluid trap member between first and second positions relative to the backing plate.
US08906158B2 Method for producing compound semiconductor epitaxial substrate having PN junction
Disclosed is a method for producing a compound semiconductor epitaxial substrate having a pn junction by selective growth which is characterized by using a base substrate having an average residual strain of not more than 1.0×10−5.
US08906156B2 Cement and concrete with reinforced material
Provided are compositions, methods and systems including cementitious compositions and reinforcing materials wherein the cementitious composition comprises a metastable component.
US08906151B2 Calcium phosphate composition and process for producing the same
A calcium phosphate composition comprising tetracalcium phosphate particles (A), calcium hydrogen phosphate particles (B) and at least one kind of inorganic particles (C) selected from silica particles or titania particles, wherein the mixing ratio (A/B) of (A) to (B) is from 45/55 to 55/45 in molar ratio, the inorganic particles (C) have an average particle diameter of from 0.002 to 0.5 μm, and the inorganic particles (C) are contained in an amount of 0.1 to 20 parts by weight based on 100 parts by weight of (A) and (B) in total. Thereby provided is a calcium phosphate composition such that when it is used as a material for bone repair, a formed bone has high mechanical strength and a high bone replacement rate is achieved.
US08906150B2 Phase change inks containing crystalline trans-cinnamic diesters and polyterpene resins
Disclosed is a phase change ink comprising an ink carrier which comprises: (a) a crystalline trans-cinnamic diester; and (b) an amorphous polyterpene resin.
US08906149B1 System for CO2 capture with improved stripper performance
The present application relates to a system for removal of gaseous contaminants from a gas stream. The system includes an absorber for contacting the gas stream with a wash solution to form a used wash stream, a regenerator for regenerating the used wash solution, a reboiler and at least two heat exchangers in fluid communication with the absorber, regenerator and reboiler.
US08906147B2 Degassing apparatus
A degassing apparatus 1 includes a housing 2 having a degassing chamber 22, a rotor 3 rotatably provided in the housing 2 and a decompressing mechanism 4 for decompressing the degassing chamber 22 of the housing 2. The housing 2 further includes a conduit line 21 and a cylindrical portion 23. The degassing chamber 22 is provided in a middle part of the conduit line 21. An upper end of the conduit line 21 constitutes an inlet port 24 and a lower end of the conduit line 21 constitutes an outlet port 25. The rotor 3 is rotatably provided inside the cylindrical portion 23 so that a passage between the outlet portion 25 and the degassing chamber 22 can be hermetically separated by the rotor 3. The rotor 3 has four partitioning plates 31 which partition the inside of the cylindrical portion into four spaces 231-234.
US08906146B2 Air dryer cartridge
The present invention relates to an air dryer cartridge designated for an air dryer of a utility vehicle. The air dryer cartridge comprises a supporting element. At least one spring is interposed between a supporting element and a pressing element for a desiccant. The supporting element is movable with respect to a housing of the air dryer cartridge. The supporting element is freely accessible from the outside of said air dryer cartridge. The present invention in particular provides the option to use the at least one spring both for pressing the desiccant as well as for clamping the air dryer cartridge in an air dryer.
US08906143B2 Membrane separation apparatus for fuel gas conditioning
Disclosed herein is a membrane separation apparatus that includes an integrated filter element and a membrane element housed within a single vessel. The vessel is configured to allow liquids to be trapped and removed from the vessel, and gases to flow to and through the membrane element. The apparatus is useful in the conditioning of fuel gas to separate methane from C2+ hydrocarbons.
US08906142B2 Phase separation of a multiphase mixture
A device for phase separation of a multiphase mixture with at least one gas and at least two fluid phases may include a vessel including a tangential inlet via which the multiphase mixture is conveyed to the vessel, a tangential gas outlet above the inlet, via which a gas phase of the multiphase mixture separated from the multiphase mixture can be taken out of the vessel, and at least two outlets below the inlet at different vertical heights, via which one of the at least two fluid phases of the multiphase mixture respectively separated from the multiphase mixture can be taken out of the vessel. Further, a method for phase separation of a multiphase mixture using such device may include imparting an upwards-directed eddy flow to the multiphase mixture, during which fluid droplets are separated from the multiphase gas mixture, collecting the fluid droplets, and separately removing all phases formed.
US08906140B2 Filtration module
A filtration module is provided that includes a filter member and a spacing member disposed in detached, contact engagement along a length of each member, such length extending about a longitudinal axis of a filtration module to define a concentric and detached plurality of filtration layers, and an interleaved, concentric and detached plurality of spacing layers, respectively. One or both of the plurality of spacing layers and plurality of filtration layers may provide a radially-inward directed force. The spacing member may be elastically deformed in the filtration module to apply a radially-inward directed force and a radially-outward directed force, wherein the filtration and spacing layers are retained in substantial fixed spatial relation. A retaining member may be located to engage an external side surface of the filtration module. A filtration module may be constructed by winding the filter member and spacing member about a longitudinal axis of the module.
US08906138B2 Methods of generating and utilizing utility gas
The present application is directed to a method and system for preparing gaseous utility streams from gaseous process streams, nitrogen process streams, and other types of streams. The methods and systems may include at least one swing adsorption process including pressure swing adsorption, temperature swing adsorption, and rapid-cycle adsorption processes to treat gaseous streams for use in dry gas seals of rotating equipment such as compressors, turbines and pumps and for other utilities. The systems and processes of the present disclosure are further applicable to high pressure gaseous streams, for example, up to about 600 bar.
US08906136B2 Selective water vapour transport membranes comprising a nanofibrous layer and methods for making the same
A water vapor transport membrane comprises a nanofibrous layer disposed on a macroporous support layer, the nanofibrous layer coated with a water permeable polymer. A method for making a water vapor transport membrane comprises forming a nanofibrous layer on a macroporous support layer and applying a water permeable polymer to the nanofibrous layer. The water permeable polymer can be applied for so that the nanofibrous layer is substantially or partially filled with the water permeable polymer, or so that the coating forms a substantially continuous layer on one surface of the nanofibrous layer. In some embodiments of the method, the nanofibrous layer is formed by electro-spinning at least one polymer on at least one side of the porous support layer. In some embodiments, the support layer is formable and the method further comprises forming a three-dimensional structure from the water vapor transport membrane, for example, by compression molding, pleating or corrugating.
US08906134B2 Engine-out soot flow rate prediction
A method for engine-out soot flow rate prediction of an exhaust gas treatment system is provided. A measured level of oxides of nitrogen in the exhaust gas treatment system is received. An engine fuel injection timing and air-fuel ratio of an engine producing the oxides of nitrogen are also received. An engine timing factor is determined based on the engine fuel injection timing. An engine air-fuel ratio factor is determined based on the engine air-fuel ratio. An engine-out soot flow rate prediction is generated based on the measured level of oxides of nitrogen, the engine timing factor, and the engine air-fuel ratio factor.
US08906130B2 Coatings and powders, methods of making same, and uses thereof
This invention relates to thermal spray coatings, powders useful in deposition of the thermal spray coatings, methods of producing the powders, and uses of the thermal spray coatings, for example, coating of piston rings and cylinder liners of internal combustion engines. The coatings of this invention are applied by thermal spray deposition of a powder. The powder contains bimetallic carbides of chromium and molybdenum dispersed in a matrix metal. The matrix metal contains nickel/chromium/molybdenum.
US08906129B2 Copper alloy for sliding materials
A copper alloy having excellent sliding performance is produced without relying on lead or molybdenum. The copper alloy contains a sintered Cu5FeS4 material produced by sintering a raw material powder that comprises Cu, Fe and S and is produced by a gas atomizing method.
US08906128B2 Air filter arrangement; assembly; and, methods
An air filter arrangement is disclosed. The air filter arrangement includes media comprising corrugated media secured to facing media and forming inlet and outlet flutes secured to one another. Media pack arrangements including such media are described. Also described are filter cartridges including such media packs and air cleaners including the filter cartridges. Advantageous housing seal arrangements having a pinch seal member and forming a trough are described. Methods of assembly and use are also provided. Also, systems of use are described.
US08906121B2 Fluidized beds, sizing of fluidized medium inlet holes and methods of fluidizing
A fluidized bed apparatus having a plurality of inlet holes for the introduction of fluidizing medium into a fluidized bed, wherein at least two, and preferably more, of the inlet holes have different cross sectional areas.
US08906119B2 Engineered fuel feed stock
Disclosed are novel engineered fuel feed stocks, feed stocks produced by the described processes, and methods of making the fuel feed stocks. Components derived from processed MSW waste streams can be used to make such feed stocks which are substantially free of glass, metals, grit and noncombustibles. These feed stocks are useful for a variety of purposes including as gasification and combustion fuels.
US08906118B2 Method for manufacturing lithium secondary battery
A method for manufacturing a lithium secondary battery includes a first step of dispersing a conductive material in a solvent to prepare a conductive slurry; and a second step of mixing the prepared conductive slurry, a positive electrode active material and a binder to prepare a positive electrode mixture layer-forming slurry; wherein the first step is conducted so that a ratio of a particle size at 10% accumulation to a particle size at 90% accumulation, which are based on a particle size distribution measurement of the conductive material, is 10 or more and 200 or less.
US08906115B2 Method for the antimicrobial finishing of textiles and fibers
A method for the antimicrobial finishing of synthetic fibers, in which an aqueous solution of an organic primer component (P), such as, for example, gallic acid, and, as antimicrobial component (K), at least one organic quaternary ammonium compound, and a metal salt component (M) are applied at the same time or at a different time to the fibers, permits permanent antimicrobial finishing.
US08906113B2 Prosthesis
The invention relates to a prosthesis with a prosthesis socket which has an inner face and is designed to be arranged on an amputation stump after a liner has been pulled over the latter, such that the inner face is directed toward the liner and a volume is enclosed between the inner face and the liner, and with a pump for generating an underpressure in the volume when the prosthesis socket is arranged on the amputation stump, characterized in that the pump is a peristaltic pump (1).
US08906110B2 Two piece cancellous construct for cartilage repair
The invention is directed toward a cartilage repair assembly comprising a shaped allograft two piece construct with a demineralized cancellous cap and a mineralized cylindrical base member defining a blind bore with a through-going transverse bore intersecting the blind bore. The demineralized cancellous cap has a cylindrical top portion and a smaller diameter cylindrical stem extending away from the top portion which fits into the blind bore of the mineralized base member. The cap stem defines a transverse through-going bore which is aligned with the through-going bore of the base member to receive a cylindrical cortical pin holding the cap within the base member. The shaped structure is dimensioned to fit in a drilled bore in a cartilage defect area so that the assembly engages the side wall of the drilled bore in an interference fit.
US08906109B2 Modular lateral hip augments
An implant for a hip can include a lateral augment adapted to be coupled to a lateral side of a femoral body implant. The lateral augment can include a body portion having a first surface, a second surface opposite the first surface, and a protrusion extending from the second surface. The protrusion can have a shape adapted to mate with a complementary shaped recess formed in the lateral side of the femoral body implant. An aperture can be positioned in the body portion and extend through the protrusion. A fastener can be received through the aperture and adapted to be threadably secured to the lateral bore. The fastener can be configured to have a length sufficient to pass through a portion of a greater trochanter for securing the portion of the greater trochanter and the lateral augment to the femoral body implant.
US08906106B2 Tibial prosthetic component for a partial or unicondylar bearing knee replacement, method of selecting such a tibial prosthetic component, method of implanting such a tibial prosthetic component and a kit for a surgeon
The invention concerns a tibial prosthetic component comprising a plate (100) for forming a tibial plateau of a tibia (16), wherein a peripheral region of the plate (100) has a thickness of less than 3 mm. The invention also concerns a tibial prosthetic component having a keel of depth less than 9 mm. The invention also concerns a method of selecting a tibial prosthetic component comprising receiving measurements of at least one physical attribute of an individual into whom the tibial prosthetic component is to be implanted, selecting a thickness of a plate (100) and depth of keel of the tibial prosthetic component based on the measurements and providing a tibial prosthetic component comprising a plate (100) having the selected thickness and a keel having the selected depth. The invention may also comprise implanting a tibial prosthetic component selected in accordance with this method into an individual and a kit comprising a plurality of prosthetic components comprising plates having different thicknesses with keels of different depths.
US08906101B2 Interbody vertebral prosthetic and orthopedic fusion device with self-deploying anchors
A method of inserting an intervertebral prosthesis into an intervertebral space between respective endplates of adjacent first and second vertebral bones of a spine, includes: placing the intervertebral prosthesis into the intervertebral space, the intervertebral prosthesis including: a body including first and second spaced apart major surfaces and at least one sidewall extending therebetween, the first major surface for engaging the endplate of the first vertebral bone, and the second major surface for engaging the endplate of the second vertebral bone, and the first and second major surfaces defining a longitudinal axis extending substantially normal to said surfaces; and simultaneously pushing at least three anchoring elements from within the body of the intervertebral prosthesis out through at least three respective apertures in the body and into at least one of the first and second vertebral bones, without rotating the at least one anchoring element about an axis thereof.
US08906100B2 Methods and apparatus for vertebral body distraction and fusion employing flexure members
Improved methods and apparatuses for vertebral body distraction and fusion in accordance with various embodiments of the present invention employ flexure members. Flexure members connect a plurality of structural members to end plates on one end and blocks on another end. Upon insertion into the disc space, a drive screw or similar mechanism can be actuated to drive expansion blocks closer together, which causes flexure members to deflect, resulting in expansion of the structural members and distraction of the end plates. The distracted device can then remain in the body and be used for vertebral body fusion.
US08906097B2 Intervertebral implant facilitating unilateral placement, instruments and methods
Implants, tools and methods for performing unilateral posterior lumbar interbody fusion are provided. An interbody implant includes a body having a top and bottom surface extending along a length thereof; and first and second side surfaces extending between the top and bottom surfaces on opposite sides of the body. The height of the first side surface is greater than the height of the second side surface.
US08906093B2 Devices and methods for facilitating controlled bone growth or repair
Bone implantable devices and methodologies permit careful application of biologically active substances and management of bone growth processes. The device includes a body defining a carrier receiving area for locating adjacent bone. Carrier material is located in the carrier receiving area. Substance is delivered onto carrier material through a port. A pathway delivers substance from the carrier receiving area to the bone surface. The body may be in the form of a spinal fusion cage, facet fusion screw, artificial joint, bone fixation plate, interbody graft, IM nail, hip stem, or other bone-to-bone appliances or bone-to-device appliances. In use, carrier is installed in the carrier receiving area of the device. The device is then implanted adjacent a bone. The substance is applied to the carrier for subsequent delivery to the bone. By doping carrier material after device implantation, inadvertent contact of the substance with non-target bone is more easily eliminated.
US08906089B2 Multifocal ophthalmic lens
A method of designing a multifocal ophthalmic lens with one base focus and at least one additional focus, capable of reducing aberrations of the eye for at least one of the foci after its implantation, comprising the steps of: (i) characterizing at least one corneal surface as a mathematical model; (ii) calculating the resulting aberrations of said corneal surface(s) by employing said mathematical model; (iii) modelling the multifocal ophthalmic lens such that a wavefront arriving from an optical system comprising said lens and said at least one corneal surface obtains reduced aberrations for at least one of the foci. There is also disclosed a method of selecting a multifocal intraocular lens, a method of designing a multifocal ophthalmic lens based on corneal data from a group of patients, and a multifocal ophthalmic lens.
US08906087B2 Method of making implantable devices with reduced needle puncture site leakage
A prosthetic implantable device that offers a reduction in fluid loss when the device is punctured, such as by a dialysis needle or suture needle, and the needle is subsequently removed. The device may be made to be thin and flexible, and with longitudinal stretch, in order that it also offers good handling and kink resistance to a surgeon. While the device is preferably of tubular form, flat sheets or other forms may also be made. The device includes inner and outer layers of a porous material having a microstructure of nodes interconnected by bent fibrils, and having void spaces between adjacent bent fibrils. The inner and outer layers are joined by an elastomeric adhesive that may interpenetrate the void spaces of the adjacent surfaces of the inner and outer layers, that is, the inner surface of the outer layer and the outer surface of the inner layer.
US08906086B2 Endovascular stent graft with self-closing perfusion branch
A prosthesis having a tubular body of a biocompatible graft material having a proximal end, a distal end, a lumen therethrough, and a sidewall. The prosthesis includes at least one perfusion branch extending from the sidewall of the tubular body and having a proximal end, a distal end, and a lumen therethrough, where the lumen of the perfusion branch is in temporary fluid communication with the lumen of the tubular body. The perfusion branch comprises a self-sealing component, that after predetermined period of time precludes fluid flow out of the distal end of the perfusion branch.
US08906085B2 Stent segments axially connected by thin film
In accordance with the present invention, there is provided a stent for insertion into a vessel of a patient. The stent has a front and back open ends and a longitudinal axis extending therebetween. The stent has a plurality of adjacent hoops that are held in alignment with the longitudinal axis between the front and back open ends by a thin film tube. The hoops are attached to either the inner or outer surface of the thin film tube. The stent is compressed into a first smaller diameter for insertion into the vessel with a delivery tube and a second larger diameter for deployment into the vessel. The inventive stent can be retracted into the delivery tube if it is improperly deployed.
US08906084B2 System and methods for endovascular aneurysm treatment
Embodiments provide methods and systems for treating aneurysms using filling structures filled with a curable medium. An embodiment of a method comprises positioning at least one double-walled filling structure across the aneurysm and filling the structure(s) with a filling medium so that an outer wall conforms to the inside of the aneurysm and an inner wall forms a generally tubular lumen to provide for blood flow. The lumen is supported with a balloon or other expandable device while and/or after filling. The pressure within the structure and/or in the space between an external wall of the structure and the aneurysm wall is monitored and a flow of the medium into the structure is controlled responsive to the pressure. The pressure can also be used to determine a filling endpoint. The medium is hardened while the lumen remains supported by the balloon. The balloon is then removed after the medium hardens.
US08906083B2 Stent valves and uses of same
The invention includes a medical device and more specifically relates to a valve found generally within a frame. In a preferred device, the frame preferably comprises a self-expanding stent frame, and the valve has at least one expandable and contractible pocket member within the stent frame for resisting and permitting fluid flow, respectively.
US08906082B2 Graft apparatus
Stents and methods of using stents are provided. Stents of the invention provide external support structure for a blood vessel segment disposed within, wherein the stents are capable of resilient radial expansion in a manner mimicking the compliance properties of an artery. The stent may be formed of a knitted or braided mesh formed so as to provide the needed compliance properties. A venous graft with the stent and a vein segment disposed within is provided, wherein graft is capable of mimicking the compliance properties of an artery. Methods of selecting stents for downsizing and methods of using the stents of the invention in downsizing and smoothening are provided. Methods of replacing a section of an artery with a venous graft including a stent of the invention are provided. Methods of reducing intimal hyperplasia in implanted vein segment in a venous graft using stents of the invention are provided.
US08906076B2 Angulated locking plate and screw
An improved fixation plate using at least a double helix screw as disclosed. The double helix screw may include alternate embodiments comprising three, four, or more threads. The helix thread screw intertwines with double helix thread in the screw hole of the fixation plate providing enhanced fixation to a fractured bone.
US08906072B2 Low profile periartiular tension band plating system with soft tissue neutralization cable tunnel/channel for use on the greater trochanter
A bone plating system comprising: a plate, where the plate is low-profile and capable of contouring to a bone; a variable number of screw holes, locking or non-locking; at least one channel or tunnel through the plate; and at least one flexible device passing through the channel or tunnel and passing through soft tissue attached to the bone. The low profile plate, in combination with the flexible device passing through the surrounding soft tissue, functions as a tension band and acts to neutralize the muscle forces tending to pull the bone apart at a fracture. The low profile tension band plating system is targeted for periarticular tensile fractures for repair of the greater trochanter.
US08906060B2 Method and apparatus for soft tissue fixation to bone
A bone anchor having a rivet having a proximal end and a head distal to an elongate body, a sleeve having an internal channel for slidably receiving the body, and an expansion nut having a channel therethrough for slidably receiving said body, proximal of said sleeve is provided. The sleeve further has a shoulder provided within the internal channel in the region of the proximal end for engaging the expansion nut. The rivet, sleeve and expansion nut are arranged such that movement of the rivet from a first position to a second position causes the sleeve to cam over the rivet head and expansion nut until said expansion nut engages said shoulder, forcing the sleeve to expand into a wall of a bone hole.
US08906059B2 Vascular hole closure device
A device for closing an aperture in a vessel wall comprising a covering member having a longitudinal axis and positionable inside the vessel against the internal opening of the aperture and having a dimension to prevent egress of fluid through the aperture. Two curved legs are provided having portions positionable external of the vessel and having first and second loop portions positioned external to the internal region of the vessel wall to contact tissue.
US08906055B2 Contact activated lancet device
A lancet device including a housing and a lancet structure having a puncturing element. The lancet structure disposed within the housing and adapted for movement between a retaining or pre-actuated position wherein the puncturing element is retained within the housing, and a puncturing position wherein the puncturing element extends through a forward end of the housing. The lancet device includes a drive spring disposed within the housing for biasing the lancet structure toward the puncturing position, and a retaining hub retaining the lancet structure in the retracted position against the bias of the drive spring. The retaining hub includes a pivotal lever in interference engagement with the lancet structure. An actuator within the housing pivots the lever, thereby moving the lancet structure toward the rearward end of the housing to at least partially compress the drive spring, and releasing the lever from interference engagement with the lancet structure.
US08906052B1 Method and device for the treatment of hypertrophic cardiomyopathy
A method and device for the treatment of hypertrophic cardiomyopathy. The device includes a cutting device for resection of a thickened myocardium. The operator positions the cutting device adjacent to the myocardium that is to be resected and then slides a tubular blade within an outer shell of the cutting device to resect the septum.
US08906048B2 Modular vessel harvesting system and method
A vessel harvesting system that is suitable for harvesting target vessels such as the saphenous vein or radial artery for cardiac artery bypass graft surgery. The system includes a vessel harvesting tool with an elongated cannula and a plurality of surgical instruments therein for separating the target vessels from the surrounding tissue and side branches. The harvesting tool includes a modular handle unit with a base attached to the elongated cannula and a sled that can adapt the base to various types of vessel severing/securing tools, such as tissue welders, bipolar scissors, and bipolar bisectors. The handle unit may be relatively rigid and integrated with the various tool movement controls to facilitate one-handed operation by a user. A severing/securing tool rotation mechanism may be incorporated within the handle and operated by a thumbwheel or other such mechanism. The vessel harvesting system may also provide distal CO2 insufflation for enhanced maintenance of the operating cavity.
US08906042B2 Wound closure device including mesh barrier
A suturing device includes an elongate shaft defining a longitudinal axis, a trajectory guide translatably mounted on the elongate shaft and an introducer guard member operatively coupled to a distal portion of the elongate shaft. The introducer guard member includes at least one arm member which is movable between a first position in which the arm member is retracted, substantially in alignment with the longitudinal axis and a second position in which the at least one arm member is deployed. The introducer guard member includes an attaching member for releasably retaining a suture. The trajectory guide defines at least one bore therethrough. The bore obliquely extends through the trajectory guide and defines an angle with respect to the longitudinal axis. The bore aligns with the attaching member when the introducer guard member is in the second position.
US08906039B2 Suturing device
A suturing device includes a housing; a helical needle rotatably mounted relative to the housing; and a drive assembly for rotating the needle relative to the housing whereby the helical needle carries a suture through tissue to be sutured. The needle rotates relative to the housing in an axially fixed position and carries a suture for rapid and reliable deployment to close a wound or incision.
US08906037B2 Methods and devices for forming a tissue fold
A device for forming a tissue fold includes a recess and an opening at the end of the recess. Tissue is drawn into the recess and through the opening using a tissue engaging element. As the tissue is drawn through the opening, the tissue layers are compressed together. A fastener is used to secure the tissue fold.
US08906034B2 Instrument and method for spinal compression and distraction
An orthopedic instrument for compression and distraction of bone segments includes a first receiver, a second receiver, a positioner member, and a guide member. The first receiver includes a first receiver aperture that receives a first screw extender. The second receiver includes a second extender aperture that receives a second screw extender. The positioner member translates the second receiver relative to the first receiver to apply one of a compression and a distraction force on the screw extenders. The guide member parallel to the positioner member guides the second receiver relative to the first receiver.
US08906033B2 Cervical motion disc inserter
A novel inserter for inserting a prosthetic cervical motion disc, wherein the distal end portion of the inserter features a pair of projections that are adapted to move slidably and transversely relative to one another (like a wrench) in order to engage a prosthetic cervical motion disc.
US08906032B2 Instruments for a variable angle approach to a joint
Instruments and associated methods are disclosed for treating joints, and particularly bone tissue. One of these instruments may be a positioning instrument for controlled delivery of a device to a target site of the bone tissue being treated. The positioning instrument may comprise a main body extending at one end into an indicator probe for visual determination of a target site of a bone to be treated, and at an opposite end into a handle. A rail extends from the main body. The instrument also includes an alignment guide having a device portal for insertion of a device therethrough, the alignment guide being detachable and movable along a length of the rail. The device may comprise an implant insertion tool, an injection catheter, a cavity creation tool such as a bone drill, for example, or the device may be an implantable device.
US08906031B2 Systems and methods for internal bone fixation
Internal bone fixation devices and methods for using the devices for repairing a weakened or fractured bone are disclosed herein. A device for use in repairing a fractured bone includes a delivery catheter having an elongated shaft with a proximal end, a distal end, and a longitudinal axis therebetween, wherein the delivery catheter has an inner void for passage of at least one reinforcing material and an inner lumen for passage of a light source; a conformable member releasably engaging the distal end of the delivery catheter, wherein the conformable member moves from a deflated state to an inflated state when the at least one reinforcing material is delivered to the conformable member; and an adapter releasably engaging the proximal end of the delivery catheter for receiving the light source and the at least one reinforcing material.
US08906030B2 Systems and methods for internal bone fixation
Internal bone fixation devices and methods for using the devices for repairing a weakened or fractured bone are disclosed herein. In an aspect, a device for repairing a fractured bone includes a delivery catheter having an elongated shaft with a proximal end, a distal end, and a longitudinal axis therebetween, the delivery catheter having an inner void for passing at least one reinforcing material, and an inner lumen for accepting a light pipe, wherein a distal end of the inner lumen terminates in an optical lens; a conformable member releasably engaging the distal end of the delivery catheter, the conformable member moving from a deflated state to an inflated state when the at least one reinforcing material is delivered to the conformable member; and an adapter releasably engaging the proximal end of the delivery catheter for receiving the light pipe and the at least one reinforcing material.
US08906029B2 Device and method for dispensing a material with thermoplastic properties in a flowable state at an operation site in a human or animal patient
For dispensing a material with thermoplastic properties in a flowable state at an operation site in a human or animal patient, a device is used, which includes the material having thermoplastic properties in a solid state and is equipped for bringing the material into a flowable state at a distal device end positioned at the site where dispensing is desired and for driving the flowable material from this distal device end. The device comprises a rotation drive, a consumable element and a dispenser element, wherein one of the two elements is coupled to the rotation drive and wherein the consumable element comprises the material to be dispensed. The two elements are arranged with parallel longitudinal axes and the dispenser element comprises a distal end piece with a proximal face against which a distal face of the consumable element is held and advanced during dispensing.
US08906024B2 Intramedullary nail
An intramedullary nail includes an elongated body extending along a central longitudinal axis. The intramedullary nail includes a straight proximal end portion along with a straight distal end portion extending proximally from a distal end of the nail by a predetermined length and a central portion extending proximally from a proximal end of the distal end portion to a distal end of the proximal end portion. The central portion includes a first curved portion having a first length with a first radius of curvature and a second curved portion having a second length shorter than the first length and a second, non-zero radius of curvature smaller than the first radius of curvature.
US08906018B2 Surgical forceps
A forceps includes an end effector assembly having first and second jaw members moveable with respect to one another between an open position and a closed position. A knife channel having a body and a base is defined within each jaw member. A knife assembly includes a knife having a bifurcated distal end. The bifurcated end includes first and second cutting members each defining an opposed cutting surface and having a tab at a free end thereof for translation through the base of a knife channel. The knife is translatable into the channels when the jaw members are in the closed position such that the cutting members are approximated when translated through the channels. The knife is also translatable into the channels when the jaw members are in the open position such that the cutting members are flexed apart when translated through the jaw members.
US08906017B2 Apparatus system and method for coagulating and cutting tissue
A combination tissue coagulation and cutting apparatus, system and method for coagulating and cutting tissue. A clamp element includes first and second clamp members having respective first and second porous electrodes, such as sintered metal electrodes. A portion of tissue, such as a blood vessel, is held between the porous electrodes, and fluid from a fluid source can pass through the porous electrodes. The tissue portion can be coagulated when electrical current is applied to the first and second porous electrodes, and an adjustable cutting element that is associated with the clamp members is positioned to cut a segment or all of the coagulated tissue portion. In this manner, the same surgical instrument is used to coagulate and cut tissue.
US08906016B2 Surgical instrument for transmitting energy to tissue comprising steam control paths
A surgical instrument for supplying energy to tissue can comprise an end effector comprising a first jaw member and a second jaw member, wherein at least one of the first jaw member and the second jaw member is movable relative to the other to clamp tissue intermediate the first jaw member and the second jaw member. The instrument can further include an electrode configured to generate heat when electrical energy is supplied to the electrode and, in addition, at least one steam path within the electrode, wherein the at least one steam path is configured to vent steam generated when the tissue is heated by the electrode.
US08906015B2 Method and system for invasive skin treatment
A system and method for simultaneously heating a plurality of discrete skin volumes to a coagulation temperature. The system comprises an applicator containing an electrode having a plurality of spaced apart protruding conducting elements configured to contact the skin surface at a plurality of discrete locations. A controller applies a voltage to the electrode so as to simultaneously heat a plurality of skin volumes to a coagulation temperature when the applicator is applied to the skin surface.
US08906014B2 Medical instrument with endoscope
A medical instrument comprises a shaft, a work element at the distal end of the shaft, a handle with at least one movable part for actuating the work element and a securing element for securing an endoscope which has an endoscope shaft and an eyepiece. The distal end of the endoscope is able to be arranged in the area of the distal end of the shaft, and the proximal end of the endoscope is able to be arranged in the area of the handle of the instrument, and the endoscope is displaceable in the longitudinal direction of the shaft. The securing element is designed in such a way that the endoscope can be arranged on the outside of the instrument, the eyepiece of the endoscope, in the state when the latter is arranged on the instrument, lying outside the longitudinal axis of the shaft of the instrument.
US08906012B2 Electrosurgical devices with wire electrode
The invention provides an electrosurgical device and methods of use thereof. In one embodiment, the device may comprise a handle, a shaft distal to the handle, a first electrode tip and a second electrode tip adjacent a distal end of the shaft, with the first electrode tip spaced from the second electrode tip and wherein the first electrode tip comprises a first U-shaped electrode and the second electrode tip comprises a second U-shaped electrode, and at least one fluid outlet. In another embodiment, the device may comprise a handle, a shaft distal to the handle, and a first electrode and a second electrode adjacent a distal end of the shaft with the first electrode coplanar with the second electrode and comprising a wire electrode having a U-shape which surrounds a perimeter of the second electrode and is spaced from the second electrode by an aperture.
US08906010B2 Graphical user interface for association with an electrode structure deployed in contact with a tissue region
Systems and methods deploy an electrode structure in contact with the tissue region. The electrode structure carries a sensor at a known location on the electrode structure to monitor an operating condition. The systems and methods provide an interface, which generate an idealized image of the electrode structure and an indicator image to represent the monitored operating condition in a spatial position on the idealized image corresponding to the location of the sensor on the electrode structure. The interface displays a view image comprising the idealized image and indicator image. The systems and methods cause the electrode structure to apply energy to heat the tissue region while the view image is displayed on the display screen.
US08906009B2 Tissue treatment apparatus with functional mechanical stimulation and methods for reducing pain during tissue treatments
Apparatus and methods for delivering electromagnetic energy to a patient's tissue with a reduction in the pain experienced by the patient. The tissue treatment apparatus includes a delivery device configured to transfer electromagnetic energy through the skin surface to a region of tissue and a vibration device mechanically coupled with the delivery device. The vibration device is configured to transfer mechanical vibrations through the skin surface to the region of tissue.
US08906008B2 Electrosurgical instrument
An electrosurgical instrument is provided and includes an elongated housing having proximal and distal ends. The proximal end configured to couple to a source of electrosurgical energy via first and second channels extending along a length of the housing to the distal end thereof. The distal end including a reflector having a dielectric load operably coupled thereto and configured to receive at least a portion of the first conductor therein. In a first mode of operation, electrosurgical energy is transmitted to the first channel and reflected from the reflector to electrosurgically treat tissue. The reflector is configured to receive at least a portion of the second channel therein. In a second mode of operation, electrosurgical energy transmitted to the second channel to dissect tissue.
US08906004B2 Phase separation of cryogen in cryosurgical instrument
A cryosurgical instrument including: a shaft having a closed distal end defining an expansion chamber and an open proximal end that receives an inflow of cryogen and to exhaust a flow of expanded cryogen; and a heat exchanger with a cryogen delivery tube that spirals around a core disposed along longitudinal axis thereof. The cryogen delivery tube, at least where it spirals, is in fluid tight contact with the inner surface of the shaft so as to form spiraling cryogen exhaust pathways that extend along a portion of a length of the cryosurgical instrument from the distal end of the shaft. The cryogen delivery tube forces a two-phase flow of cryogen to undergo phase separation by centrifugal forces and urges the liquid phase against the external walls of the spiral coil and the outer surface of the spiral gap. Heat exchanging, through boiling, occurs close to the external wall of the instrument.
US08906003B2 Erodible embolization material for targeted tumor cryoablation
A method of cryoablating diseased tissue is provided. The method includes providing an embolization agent. The embolization agent includes an inner core made of a first material. The inner core has a diameter less than a diameter of an opening of a target vessel. The embolization agent further includes an erodible outer shell made of a second embolization material encompassing the inner core. The erodible outer shell has an initial diameter greater than the diameter of the opening to occlude the target vessel. The method further includes occluding the opening of the target vessel with the embolization agent to reduce blood flow in the diseased tissue. The method further includes cryoablating the diseased tissue with a cryoablation probe while the target vessel is occluded by the embolization agent.
US08906002B2 Bending joint mechanism, surgical instrument having this bending joint mechanism, and manipulator having this bending joint mechanism
A bending joint mechanism includes a joint section. The joint section includes a shaft section, an actuating section, a coupling member and a rod section. The rod section has an elastic portion which is elastically deformable in directions other than the axial direction of the shaft section.
US08906001B2 Electromechanical surgical apparatus including wire routing clock spring
An electromechanical surgical system is disclosed including a hand-held surgical instrument, an end effector configured to perform at least one function, and a shaft assembly arranged for selectively interconnecting the end effector and the surgical instrument. The shaft assembly includes a linkage having a proximal housing and a distal housing at least partially received within the proximal housing. The distal housing is rotatable relative to the proximal housing and configured to selectively interconnect the end effector to the shaft assembly. The shaft assembly further includes a wire extending through the linkage having a central portion disposed within an annular groove defined between the proximal and distal housings. The central portion of the wire is annularly wound within the annular groove to define a coil. The coil is configured to at least one of radially expand and contract upon rotation of the distal housing relative to the proximal housing.
US08905996B2 Cannulated syringe
A set of instruments configured to deliver a therapy to a bone can include a cannulated syringe. The cannulated syringe can extend along a longitudinal axis between a proximal and a distal end. The cannulated syringe can have an inner tube and an outer tube that are interconnected at the distal end as a single fixed unit. A first cannulation can be formed along the longitudinal axis of the cannulated syringe within the inner tube and a second cannulation can be formed within an annular space between the inner and outer tubes. The outer tube can define an opening through a sidewall thereof. The cannulated syringe can be closed from fluid communication between the inner and outer tubes.
US08905994B1 Valve assembly for use with liquid container and drug vial
Valve assemblies for use with a liquid container and a drug vial for enabling an initial transfer of liquid contents from the liquid container to the drug vial for liquid drug formation purposes and subsequent transfer of liquid drug contents from the drug vial to the liquid container for administration purposes. Liquid drug transfer sets can include a valve assembly pre-attached to a liquid container. Alternatively, liquid drug transfer sets can include a valve assembly packaged in sterile blister packaging ready for attachment to a liquid container prior to use.
US08905993B2 Container for an anal irrigation system
An anal irrigation system includes a tube attachable between an anal probe and a container, and a displaceable pump element. The container includes an exterior wall, an inner wall that defines an inside perimeter of the container, and a bridge piece connected between the exterior wall and the inner wall such that a reservoir space is formed between the exterior wall and the inner wall. The inside perimeter of the container provides a containment space within the container that is sized to contain the tube and the anal probe. An opening is formed in the container and communicates with the reservoir space. The reservoir space is configured to contain irrigation liquid. The displaceable pump element is located in the reservoir space, where the displaceable pump element is adapted to increase pressure in the irrigation liquid.
US08905992B2 Portable microbubble and drug mixing device
A portable microbubble and drug mixing device is provided. The portable microbubble and drug mixing device comprises a flexible outer container comprising an interior chamber for accommodating a drug, and a rigid inner container within the flexible outer container and comprising an interior chamber for accommodating microbubbles. The outer container has a tensile strength at break less than or equal to approximately 15 MPa, and the inner container has a tensile strength at break greater than or equal to approximately 20 MPa and is capable of storing microbubbles at a concentration higher than or equal to approximately 5×106 microbubbles/ml. The inner container is configured to separate the microbubbles in the interior chamber of the inner container from the drug in the interior chamber of the outer container until a point of mixing when the microbubbles are released into the interior chamber of the outer container.
US08905991B2 Combination of refastenable and releasable bonds
A process for providing a package of prefastened articles includes manufacturing an article having a chassis with an absorbent assembly located between an outer cover and a body side liner. The chassis also includes a first waist region and a second waist region; a refastenable seam joining a first distal portion of the first waist region to a first distal portion of the second waist region; a first refastenable bond connecting the first distal portion of the first waist region and the first distal portion of the second waist region. The first distal portion of the first waist region is folded and bonded to itself with a releasable bond having a first releasable bond peel strength. The first refastenable bond peel strength is greater than the first releasable bond peel strength. The process also includes rupturing the releasable bond and packaging the article.
US08905990B2 Incontinence article in pants form
The invention relates to an incontinence article (2) in the form of underpants, wherein the crotch segment (8) overlaps the belly segment (4) in a front overlapping area (36) and the crotch segment (8) overlaps with the back segment (6) in a rear overlapping area (38), wherein the outside (86) of the crotch segment (8) is inseparably joined to the inside (41) of the belly segment (4) in a front connecting area (306) and the outside (86) of the crotch segment (8) is inseparably joined to the inside (41) of the back segment (6) in a rear connecting area (308), wherein the connecting area (306, 308) of the belly segment (4) and the rear segment (6) each comprise a first joining area (310), 312) and second joining areas (314a, 314b, 316a, 316b), wherein the first joining area (310, 312) extends at least in segment below the absorption body (7), and wherein the second joining areas (314a, 314b, 316a, 316b) are provided in an area (320a, 320b, 322a, 322b) crossing each longitudinal edge (48) of the crotch segment (8), thus flashing both a partial area (324a, 324b, 326a, 326b) of the overhang (66a, 66b) of the crotch segment (8) and a partial area (328a, 328b, 330a, 330b) of the belly segment (4) and/or the back segment (6) adjacent thereto, and wherein each second joining area (314a, 314b, 316a, 316b) extends in the longitudinal direction (9), starting from a transverse edge (58, 60) of the belly segment (4) and/or the back segment (6) facing the crotch, in the direction toward the longitudinal ends (98, 100) of the crotch segment (8), and wherein each second joining area (314a, 314b, 316a, 316b) is formed by joining means (340) in the form of welding points, particularly ultrasonic welding points, thermal welding points, and/or calender welding points, so that the second joining areas (314a, 314b, 316a, 316b) form reinforcement areas (334a, 334b, 336a, 336b).
US08905988B2 Disposal bag-system for a disposable object
A disposal-bag system attached to or formed at least partially by a disposable object (e.g., a diaper) includes a container that houses a disposal bag folded into a compact arrangement. The container is generally thin and flat and sized for storing the bag, and the bag is sized for holding the disposable object that the system is used with. And the bag is at least partially removable from the container so that the disposable object can be placed into it for disposal. In use, the container is opened, the bag is extended from the container and opened, the disposable object is grasped by reaching through the bag, the bag is inverted to now hold the disposable object, and the bag is closed and disposed of. In this way, the disposal-bag system provides a convenient, sanitary, and self-contained method of disposing of soiled diapers or other disposable objects.
US08905987B2 Drainable ostomy pouch with concealed drain chute
A drainable ostomy pouch includes a collection portion and a drain chute portion extending from the collection portion and having a discharge opening for permitting emptying of contents from the pouch. The drain chute is foldable between an open condition in which the drain chute portion is extended from the collection portion, and a closed condition in which the drain chute portion is folded towards the collection portion. At least one flap retains the folded drain chute portion.
US08905986B2 System and method for collecting exudates
A reduced pressure treatment system includes a porous pad positioned at a tissue site and a canister having a collection chamber, an inlet, and an outlet. The inlet is fluidly connected to the porous pad. A reduced pressure source is fluidly connected to the outlet of the canister to such that fluid from the tissue site may be drawn into the collection chamber. A hydrophobic filter is positioned adjacent the outlet to prevent liquid from exiting the collection chamber through the outlet. A baffle is positioned within the canister to create a tortuous path between the inlet and the outlet to prevent premature blocking of the hydrophobic filter.
US08905984B2 Supply chain method and apparatus for sealing and unsealing a vacuum draw path
This application teaches a disposal chain and a supply chain system for sealing and unsealing a vacuum draw path embodying a thrust handle capable of imparting assembly and disassembly thrust forces said system conferring the potential of reducing the amount solid waste mass contributed to the waste stream.
US08905983B2 System and method for utilizing exudate with a reduced pressure treatment system to generate electricity
A method for providing reduced pressure treatment to a tissue site is further provided according to an illustrative embodiment. The method includes applying a reduced pressure to the tissue site. The method collects exudate drawn from the tissue site in a liquid collection chamber and utilizes the collected exudate in the liquid collection chamber to generate electricity.
US08905980B2 Devices for delivering a medicament and methods for ameliorating pain
A device for delivering a medicament to a patient in need thereof includes: (a) an injector including a first end configured to remain outside a nasal passage of the patient and a second end configured for entry into the nasal passage of the patient, wherein the injector is moveable between a storage position and an engaging position; and (b) an introducer configured for engagement with a nostril of the patient, wherein the introducer includes a passageway configured for slidably receiving the injector, and wherein the introducer includes a curvature along a portion thereof adjacent to the passageway. Methods for ameliorating pain in a patient include (a) introducing the injector through the nasal passage of the patient into a region substantially medial and/or posterior and/or inferior to a sphenopalatine ganglion of the patient; and (b) delivering a medicament from the injector superiorly and/or laterally and/or anteriorly towards the sphenopalatine ganglion.
US08905978B2 Non-reopening tubing clamp and method of use thereof
A medical tubing clamp includes a first member, a second member, and a hinge connecting the first and second members to form a body. The second member has a first and second wall portion extending distally toward the first member, and a shelf extending between and connecting the first and second wall portions. The first and second wall portions and the shelf define a recess. The hinge allows the first and second members to move relative to one another to transition the clamp between an open mode and a closed mode. The first member is located within the recess and supported by the shelf when in the closed mode. The hinge has a first opening configured to receive the tubing. The clamp also has a tubing closure member that deforms the tubing to prevent fluid flow through the tubing when in the closed mode.
US08905974B2 Wearable infusion device and system
Disclosed is a drug infusion system comprising a drug infusion device having a reservoir, a window for viewing the contents of the reservoir, a cannula arranged to be deployed beneath the skin of a patient, and an actuator configured to be manually actuated to drive a medicament from the reservoir to the cannula. The system also has a cannula cover and a needle handle that holds a needle for insertion into the patient. The cannula cover and needle handle are detachably attached to the drug infusion device, and each is attachable to the other. The device further comprises a septum and a septum pincher to seal the device. The device also comprises a pumping mechanism, part of which are a last-dose lock-out mechanism and an occlusion detection mechanism, both of which operate on the same actuator.
US08905971B2 Injection method and apparatus
A pen-type injector for receiving a medication containing member. The injector comprises a housing 1 and a torsion spring 4 contained within the housing and coupled to a drive member 8. A dose setting knob 2 is coupled to the spring 4, and rotatably coupled to the housing 1 such that rotation of the knob relative to the housing in a first direction results in compression or twisting of the spring. A user actuable trigger 12 is provided for releasing the spring 4 to push the drive member 8 through the housing 1. A user actuable button 6 is coupled to the housing 1 for axial motion relative thereto, said button 6 being coupled to the torsion spring 4 to cause the spring to unwind or expand in discrete steps with each press of the button.
US08905969B2 Method and system for removing air from a flow path of a fluid injection device
A method of removing air from a flow path of a medical fluid injection system is described. An exemplary method performed by the medical fluid injection device includes delivering a first amount of fluid to a fluid flow path, isolating fluid flow along the flow path, forming a vacuum condition upstream of the fluid isolation, re-establishing fluid communications along the flow path, and delivering a second amount of fluid to the flow path.
US08905968B2 System for cooling and pressurizing fluid
A pump for delivering a fluid, created by cooling and pressurizing a fluid, into the intrathecal space of a patient, the pump comprising an input channel, an input reservoir in fluid communication with the input channel, a cooling apparatus configured to remove heat from the fluid and a pressurizing mechanism configured to impart pressure to the fluid, an output reservoir, and an output channel, and wherein the output channel is configured to be in fluid communication with a first lumen of a catheter and wherein the first lumen of the catheter is configured to be disposed within the intrathecal space of the patient.
US08905963B2 Injector apparatus and method for drug delivery
Methods and apparatus provide a therapeutic fluid to devices implanted in the body, for example to containers of devices implanted in the eye of a patient. The methods and apparatus may comprise an injector to increase an amount of therapeutic agent injected into the device implanted in the eye, or a structure to receive the therapeutic fluid within the device implanted in the eye, or combinations thereof. The device implanted in the eye may comprise a reservoir chamber having a fluid with a density different than the therapeutic fluid, and the apparatus can be adapted to at least partially separate the implanted device fluid from therapeutic fluid within the reservoir chamber to increase and amount of therapeutic fluid placed in the reservoir chamber.
US08905960B2 Device for the filtering a complex liquid such as blood, in particularly applicable to an autotransfuser
A device for the filtration of a complex fluid composition such as blood, includes a base (12) with a bottom (18), a top (14) with a bottom (30), and a membrane (16) that is arranged between the base and the top so as to define a low chamber C1 and a high chamber C2, with an input tap (26) of the complex composition that is to be filtered emptying into the low chamber C1, an output tap (28) of the retentate with elements for adjusting the flow rate emptying into this same low chamber C1, and an output tap (36, 36-1) of the high chamber C2, whereby this output tap (36, 36-1) of the permeate is subjected to negative pressure.
US08905958B2 Traction apparatus and methods
A brace and traction device and associated methods of operation. In one embodiment, the device incorporates a forwardly open head and jaw brace which is adjustably supported vertically above a forwardly collar member. The brace and the collar member are adapted such that the brace is able to mate with the collar member while still being able to rotate to the subject's left and right while remaining planar to the collar member. Adjustment may be accomplished for example manually or via an electronic motor controlled by a control mechanism and microprocessor. The microprocessor may be adapted to store information regarding a user's sessions, and facilitate communication with patient and physician personal devices, thus sending these data from recorded sessions. The processor element may also be adapted to implement therapy sessions based on physician-entered program specifications, or based on pre-programmed specifications.
US08905955B2 Locomotion assisting device and method
An exoskeleton bracing system includes: a trunk support for affixing to the trunk of a disabled person and leg braces for connecting to the legs of the person, each leg brace including limb segment braces. Motorized joints are adapted to provide relative angular movement between the limb segment braces of the leg braces and between the leg braces and the trunk support. One or more ground force sensors are designed to sense ground force exerted on each of the leg braces. The system also includes a controller for receiving sensed signals from said one or more ground force sensors, with an algorithm for identifying a stance from the sensed signals and, based on the identified stance, actuating the motorized joints to perform an action relating to a mode of locomotion selected from a set of predefined actions corresponding to the identified stance.
US08905947B2 System and method for tongue force detection and exercise
A force sensing and exercise device for assessment and therapeutic usage is described herein. The force sensing device may include a registration plate, to form a ridge with a body part of a patient and provide a fixed point from which measurements are taken. The force sensing device allows for linear movement as a component of the measurement and the ability to vary exercise resistance continuously over an exercise range. Tactile and auditory feedback is provided to a patient to indicate than an exercise objective has been achieved.
US08905945B2 Method and apparatus for penetrating tissue
A body fluid sampling system for use on a tissue site includes a single drive force generator. A plurality of penetrating members are operatively coupled to the force generator. The force generator moves each of the members along a path out of a housing with a penetrating member exit, into the tissue site, stops in the tissue site, and withdraws out of the tissue site. A flexible support member couples the penetrating members to define a linear array. The support member is movable and configured to move each of the penetrating members to a launch position associated with the force generator.
US08905943B2 Biopsy device with rotatable tissue sample holder
A biopsy device comprises a probe body, a cannula extending distally from the probe body, a cutter moveable relative to the cannula to sever tissue, and a tissue sample holder coupled with the probe body. The tissue sample holder comprises a rotatable member having a plurality of recesses to receive tissue samples. The rotatable member can be operable to successively index each recess relative to a lumen defined by the cutter. A cover portion may be associated with the rotatable member and permits one or more recesses to be viewable through the cover. The recesses may be configured to carry one or more tissue samples as the rotatable member is rotated.
US08905941B2 Guidance method, apparatus thereof, recording medium storing program thereof, and device
A first evaluation mode and a second evaluation mode for evaluating with a criterion different from the first evaluation mode are set and the second evaluation mode is applied to acquired information before application of the first evaluation mode to output the evaluation result. A user recognizes that the evaluation result is acquired from the current finger placement. If a change is made in the evaluation result by making transition from the second evaluation mode to the first evaluation mode, the user sensuously recognizes again that the finger placement is not proper from the evaluation result and is prompted to perform a correct operation of the finger position.
US08905938B2 Bio-impedance sensor and sensing method
Implantable medical devices and techniques are implemented that use bio-impedance to measure aspects of patient physiology. A signal separation method is performed at least in part in an implantable device. The method involves detecting a plurality of impedance signals using a plurality of implantable electrodes coupled to the implantable device. The method further involves separating one or more signals from the plurality of impedance signals using a signal separation technique, such as an algorithm-based separation technique.
US08905936B2 Catheter having a biasing member
A catheter includes a catheter main body provided with a window portion through which an inspection wave passes, a drive shaft provided with a detection unit detecting the inspection wave and concurrently installed advanceably and retractably in an axial direction inside the catheter main body, and a bias member biasing a force onto the drive shaft for moving the drive shaft forward toward the distal side thereof.
US08905934B2 Ultrasound transducer, ultrasound probe, and ultrasound diagnostic apparatus
Object is that an output sound pressure at transmission or an output voltage at reception of a predetermined higher resonance component becomes higher than those of the primary resonance component. The piezoelectric material layer 24 has an electrode on the surface of the piezoelectric material of between the layer and both ends, and outputs and inputs an electrical signal with this electrode. The piezoelectric material 24 has a remanent polarization in a thickness direction, the relationship of the (4P+1)th layer piezoelectric material from fixed end side is used as the basic relationship, piezoelectric materials are periodically arranged so that piezoelectric materials of (4p+2)th and (4p+3)th layer each has an opposite relationship, and (4p+4)th layer has the same relationship as the basic relationship. On the fixed-end side of the piezoelectric material layer 24, provided is the de-matching layer 23 with larger acoustic impedance than the piezoelectric material layer 24 for reflecting vibration propagated from the piezoelectric material layer 24 to the fixed-end side.
US08905930B2 Infusion pressure control using blood pressure
Methods, systems, and software for controlling infusion pressure, such as during a medical procedure, using systemic blood pressure are described. Systemic blood pressure, such as brachial arm blood pressure or radial artery blood pressure, may be used to estimate central retinal artery blood pressure to estimate critical closing pressure. Further, the disclosure relates to controlling infusion pressure to prevent an increase in intraocular pressure above the estimated critical closing pressure when such is not desired, and, when such is desired, using systemic blood pressure and infusion pressure to control an intentional increase in intraocular pressure above the estimated critical closing pressure to stop intraocular bleeding.
US08905924B2 Illuminated dental prop
The present invention relates to an illuminated dental prop for holding a patient's mouth open during dental procedures. The illuminated dental prop is completely disposed within the patient's mouth during use and includes a body portion and a lighting assembly that is selectively detachable from the body to allow for intense sterilization of the components after use. Under certain embodiments of the invention, the body portion and/or the lighting assembly will be disposable after a single use.
US08905921B2 Optical coupler for an endoscope
An optical coupler is disclosed with an attachment section for mounting at a distal end of an optical imaging device for visualizing a surface area covered with an opaque fluid and/or particulate matter. The coupler includes a visualization section at one end of the coupler that includes a proximal surface for engaging the distal end of the optical imaging device, an attachment section connected to and extending away from the visualization section, an outer surface spaced apart from the proximal surface, and may include a hollow instrument channel extending from the proximal surface toward the outer surface. This surface extends continuously from a first outer side boundary across to a second opposite outer side boundary of the visualization section. The visualization section can be formed from an elastic material capable of transmitting an optical image of the surface area. In one form, the material is a silicone gel or elastomer.
US08905914B2 Gastric band device and method
An apparatus for forming a gastric restriction includes an implantable band and at least one tab. In some versions, the at least one tab may serve to stabilize the apparatus as it forms a gastric restriction. In some versions, an opening may be formed in the tabs such that sutures may be used. In some versions, a tissue scaffold and/or matrix may be used on the implantable band and/or the tabs to facilitate long term support for the implantable band, such as by substantially preventing the implantable band from sliding along an axis defined by an anatomical structure about which the implantable band is wrapped.
US08905911B2 Surgical slings
The invention relates generally to surgical implants, and in various embodiments to surgical implants configured for promoting growth of well-organized collagenous tissue at an anatomical site.
US08905910B2 Fluid delivery system and method for monitoring fluid delivery system
A fluid delivery system includes an electric motor, a pump driven by the electric motor, and a control system. The control system is programmed to supply a variable voltage to the electric motor, to sense a response of a current of the electric motor to the variable voltage, and to obtain frequency domain information about the response of the current of the electric motor.