Document Document Title
US08860325B2 High efficiency LED driver and driving method thereof
The present invention relates to a high efficiency LED driver and driving method thereof. In one embodiment, a high efficiency LED driving method configured for a LED device can include: (i) receiving a DC bus voltage and generating a driving voltage for the LED device through a power switch; (ii) comparing the DC bus voltage against a sum of the driving voltage and a first reference voltage; (iii) where when the DC bus voltage is greater than the sum of the driving voltage and the first reference voltage, generating a first output current; (iv) where when the DC bus voltage is greater than the driving voltage and less than the sum of the driving voltage and the first reference voltage, generating a second output current; and (v) matching an average current of the first output current and the second output current with a corresponding driving current.
US08860323B2 Plasma lamp with lumped components
An electrodeless plasma lamp is provided. The lamp includes a conductive enclosure including a dielectric material (e.g., air) and a bulb containing a fill to form a light emitting plasma. A radio frequency (RF) power source is coupled into to the enclosure. At least one conductive applicator applies power from the enclosure to the bulb and at least one limped inductive element is coupled between the RF feed and applicator. The lumped inductive element may be a helically wound coil. In an example embodiment, the lamp includes first and second lumped inductive elements. The first and second lumped inductive elements may extend from opposed end walls of the enclosure. The first lumped inductive element may be connected to a first conductive applicator located proximate a first end of the bulb and the second lumped inductive element may be connected to a second conductive applicator located proximate a second end of the bulb.
US08860311B2 Lighting apparatus
A lighting apparatus includes an emitter having a plasma bulb and a driver which provides an RF signal to the emitter to drive the plasma bulb. The lighting apparatus may be used for various applications including illuminating plants and organisms in an aquatic environment, growing plants, facility lighting, and other applications.
US08860309B2 Multi-tubular LED light bulb
The multi-tubular LED light bulb has a seat having a power plug, multiple glass tubes mounted on the seat, multiple multi-directional lighting LED strips respectively mounted inside the glass tubes and an AC to DC converting circuit board mounted inside the seat and connected to the power plug to obtain AC power and converting the AC power to DC power. The multi-directional lighting LED strips are electronically connected to the DC power source from the AC to DC converting circuit in parallel. Since the LED light bulb has multiple multi-directional lighting LED strips, different directional sightings and even brightness are provided. Further, heat from the LED strip is easily and quickly transmitted to the sidewall of the glass tube to extend the lifetime of the LED light bulb, since the multi-directional lighting LED strips are close to a sidewall of the corresponding glass tube.
US08860308B2 High-pressure discharge lamp having a starting aid
In various embodiments, a high-pressure discharge lamp including a starting aid and a longitudinal axis having a ceramic discharge vessel that is housed in an outer bulb, the discharge vessel having two ends having including capillaries with electrodes fastened therein, wherein a frame having a hanger wire holds the discharge vessel in the outer bulb and the hanger wire is configured so that it includes a plate-like starting aid toward the capillary of the opposite-pole electrode, with the plate-like starting aid being configured as a foil or metal sheet and the plate-like starting aid further including a means for purely mechanical fastening to at least the capillary.
US08860306B2 Display device having a fibrous encapsulating structure
An object is to provide a highly reliable light emitting device which is thin and is not damaged by external local pressure. Further, another object is to manufacture a light emitting device with a high yield by preventing defects of a shape and characteristics due to external stress in a manufacture process. A light emitting element is sealed between a first structure body in which a fibrous body is impregnated with an organic resin and a second structure body in which a fibrous body is impregnated with an organic resin, whereby a highly reliable light emitting device which is thin and has intensity can be provided. Further, a light emitting device can be manufactured with a high yield by preventing defects of a shape and characteristics in a manufacture process.
US08860303B2 Organic light-emitting display device and method of manufacturing the same
The organic light-emitting display device includes: a substrate including a transistor region; and a thin-film transistor formed over the transistor region of the substrate and having a planarization film which is disposed over a source/drain electrode and a pixel defining layer which includes an aperture exposing a portion of a first electrode electrically connected to the source/drain electrode and defining a pixel region, wherein an outgassing hole is formed in a region of the pixel defining layer other than the aperture to expose the planarization film.
US08860300B2 Color-temperature-tunable device
A method of operating a color-temperature-tunable device is described. The method drives a first light emitting diode (LED) chip with a first driving current from a first power source. The first LED chip is configured to emit a first light having a first peak wavelength. The method also drives a second LED chip with a second driving current from a second power source. The second LED chip is configured to emit a second light having a second peak wavelength. The method further maintains a total driving current, which includes the first driving current and the second driving current, approximately constant. The second peak wavelength is different from the first peak wavelength.
US08860299B2 Organic light-emitting display device and method of manufacturing the same
An organic light-emitting display device and a method of manufacturing the same are presented. The organic light-emitting display device includes substrate; a display unit comprising a plurality of emission regions in which organic light-emitting devices are disposed, and a pixel-defining layer having openings defining the emission regions, the emission regions and the pixel-defining film being formed on the substrate; an encapsulation thin film that covers the display unit on the substrate and that comprises a plurality of stacked insulating layers; and a color film that is interposed between the insulating layers of the encapsulation thin film and that is formed to at least fill a concave portion corresponding to each of the openings.
US08860298B2 Display and manufacturing method thereof
A display and a manufacturing method thereof are provided. The display includes a frame, an organic light-emitting diode (OLED) panel, a transparent element and a glue. The OLED panel is disposed in the frame. The transparent element is disposed on the OLED panel. The glue is filled between the OLED panel and the transparent element and between the OLED panel and the frame.
US08860297B2 Display device
A display device in which pixels each including an emission area are arranged in a form of a matrix, the display device including: a first electrode formed from the emission area of the pixels to a non-emission area on a periphery of the emission area; a second electrode formed so as to be common to the pixels; and a light emitting material layer formed between the first electrode and the second electrode; wherein film thickness in the non-emission area of at least one of the first electrode and the second electrode is larger than film thickness in the emission area.
US08860294B2 Light emitting element and method for manufacturing the same
To provide a light emitting element, having: a lamination structure including a first conductive layer and a second conductive layer with a light emitting layer interposed between them; a groove structure in which the second conductive layer and the light emitting layer are divided into large and small two parts; a second conductive electrode pad that is electrically connected to the second conductive layer on the divided larger second conductive layer, a first conductive electrode pad on the divided smaller second conductive layer, and two or more electrical contacts connected to the first conductive layer so as to be independent from each other, by a conductive wiring extending to the first conductive layer, with the first conductive electrode pad as a start point.
US08860292B2 Spark plug and method of manufacturing the same
A spark plug and a method of forming the same. The spark plug having a rod-shaped center electrode extending in an axial direction, a tubular insulator having an axial hole and holding the center electrode in the axial hole, a tubular metallic shell having an end surface, an inner circumferential surface, and a gap formed between the inner circumferential surface and a forward end portion of the insulator, and a ground electrode welded to the end surface. A method of manufacturing the spark plug includes a welding step of welding the ground electrode to the end surface; and a shaping step which is performed after the welding step so as to form the inner circumferential surface, through shaping, on the metallic shell having the ground electrode welded to the end surface thereof.
US08860291B2 Spark ignition device with in-built combustion sensor
A spark plug having an integral gasoline combustion sensor is disclosed. The spark plug includes a center electrode assembly with a terminal stud at one end and a center electrode with a sparking surface at an opposite end; a generally tubular insulator surrounding the center electrode assembly; a shell surrounding the insulator and having along its length a turn-over on a first end, a barrel having an outer surface and barrel shoulder on a gasket flange thereof, a threaded portion, and a ground electrode; and a piezo sensor assembly located on the barrel shoulder proximate the outer surface of the barrel which includes a lower electrode contact, a piezo transducer, an upper electrode contact, an isolator having a convex upper surface, and an upper bushing which is attached to the barrel.
US08860289B2 LED-based light bulb device
An LED light bulb device including a bulb body, heat sink stems and LEDs. The bulb body defines an exterior and an interior region. The heat sink stems are discrete from one another and extend along the bulb body in a circumferentially spaced fashion. A first LED is directly supported by the first heat sink stem, and a second LED is directly supported by the second heat sink stem. Light from the LEDs is directed inwardly into the interior region and then outwardly from the interior region.
US08860288B2 Modulized LED apparatus with enhanced heat dissipation
A modulized LED apparatus includes a container having a chamber wall with a chamber therein, a transparent surface thereof for the container to be pervious to radiant energy and/or light. The container has an optical processing area for converging, collecting or diffusing radiant energy and/or light. A liquid refrigerant and an evaporator including a heat conductor unit and a capillary unit are in the chamber, and the capillary unit has a portion contacting the liquid refrigerant. With the heat generated by an operating LED device, the evaporator evaporates the liquid refrigerant into a gaseous phase, which then condenses on the chamber wall and thus transfers heat to the chamber wall for dissipating, and the condensed refrigerant is evaporated again by the evaporator again into the gaseous phase. Due to this thermal recycling, the refrigerant continuously transfers heat from the LED device to the ambient environment.
US08860287B2 Wind power generation systems including segmented stators
The present disclosure relates to wind power generation systems having a segmented stator with a structural element and a plurality of coils. The wind power generation systems also include a rotor adapted to be rotated by wind to induce current in the plurality of coils and a lamination stack having a plurality of lamination plates disposed about the plurality of coils and a dovetail recess formed in the lamination stack. The wind power generation systems also include a dovetail bar adapted to be received by the dovetail recess and adjusted by a bolt to engage the lamination stack and the structural element of the segmented stator to form a torque transfer interface. Torque is adapted to be transferred from the lamination stack to the segmented stator via friction at the interface.
US08860285B2 Electronic component and method for producing electronic component
An electronic component includes: a base material having a first conductive section; an oscillation piece having a second conductive section; a first member which is covered with a third conductive section making conductive contact with the first and second conductive sections and is provided between the base material and the oscillation piece; and a second member which is provided so as to be surrounded with the base material, the oscillation piece, and the first member and holds the base material and the oscillation piece.
US08860284B1 Piezoelectric multiplexer
A piezoelectric multiplexer includes an actuator and multiple bimorph beams. The actuator includes an actuator conducting head and an actuator stem, and each bimorph beam includes a conducting beam contact head and a beam stem manufactured out of bimorph material. A control voltage is selectively applied to electrical contacts coupled to the beam stems to create a piezoelectric effect that bends the selected bimorph beam and creates an electrical connection between its contact head and the conducting head of the actuator. A control circuit with a controller signals which bimorph beam to connect to the actuator. This multi-bimorph-beam piezoelectric multiplexer can be affixed to the electrical terminals of different electrical components (e.g., a transistor) to create an electrical cell that can be manufactured on a semiconductor chip or in a microelectromechanical system (MEMS) device.
US08860281B2 Multiple-gap electric rotating machine
The multiple-gap electric rotating machine includes a rotor cantilever-supported at a first axial end thereof by a rotor arm coupled to a rotating shaft. The rotor includes a laminated core of core sheets made of soft magnetic material and an end-surface core disposed on a surface of the laminated core on a second axial end of the rotor. The laminated core includes segments joined in a ring and each formed with a salient pole structure at each of radially inner and outer peripheries thereof. The end-surface core includes soft magnetic sections made of steel and non-magnetic sections made of stainless steel, which are joined together in a ring. The laminated core is held between the rotor arm and the end-surface core, and fixed to the rotor arm by rivets penetrating through the rotor arm, laminated core and the end -surface core.
US08860277B2 Stator coil segment for an electro mechanical transducer, in particular a generator and electro mechanical transducer, in particular electric generator
A stator coil segment for an electro mechanical transducer, in particular a generator for generating electric energy from mechanical energy, includes a first coil which is arranged at a first radial position along a radial direction and adapted to be connected to an input terminal of a first power electronic device. The radial direction is perpendicular to a rotation axis of the electro mechanical transducer. Further, a second coil is arranged at a second radial position along the radial direction and adapted to be connected to an input terminal of a second power electronic device, wherein the second radial position is different from the first radial position.
US08860275B2 Multi-layer arc-shaped permanent magnet machine with reduced rotational stress
An interior permanent magnet machine includes a rotor configured to magnetically interact with a stator. First and second dividers are integrally formed within the rotor and configured to create a first layer of three respective first segments. Each of the respective first segments may be substantially arc-shaped. A plurality of first magnets may be positioned in the first layer. The first magnets may be substantially arc-shaped and defined around an arc center. A third and a fourth divider may be integrally formed within the rotor and configured to create a second layer of three respective second segments. The placement of dividers or structural webs provides for increased rotational speed and reduced rotational stress compared to an undivided arc-shaped magnet configuration.
US08860274B2 Motor provided with two stators arranged radially inside and outside rotor
In a double-stator motor has a rotary shaft, an annular rotor is coupled with a rotary shaft. First and second three-phase stators are arranged inside and outside to the rotor in the radial direction and formed to generate first and second rotating magnetic fields in response to three-phase currents, respectively. The rotor has an even number of segment poles made of soft magnetic material and arranged mutually separately at positions of the rotor. The positions are equally distanced apart from the rotary shaft in the radial direction and in the circumferential direction. Each of the first and second three-phase stators has magnetic poles which are the same in the number of poles as the segment poles and the magnetic poles are positioned such that magnetomotive forces from the magnetic poles are faced to each other between the magnetic poles of the first and second three-phase stators.
US08860273B2 External field interaction motor
Apparatus and associated methods involve thrust generation by interaction of an armature field with a stator field in an arrangement with substantially reduced flux coupling from the armature to the stator coil. In an illustrative example, solenoid coil segments may be arranged as the stator along a path of motion for the armature. In some examples, each armature may surround and overlap with at least one of the toroidal coil segments. Counter-electromotive force may be substantially reduced, for example, by stopping current flow in a stator coil while overlapped by the armature or while substantial armature flux couples to the stator coil. Thrust may be generated, in some examples, by interaction of armature and stator coil flux in arc-shaped regions external to and between each of the leading and trailing edges of the armature and their respective nearby stator coils.
US08860271B2 Rotating electric machine
A rotating electric machine includes a stator and a rotor. The rotor includes an iron core and permanent magnets. The iron core includes a cylindrical connection portion and ten magnetic pole portions. The cylindrical connection portion surrounds a rotation shaft. The ten magnetic pole portions, the number of which corresponding to the number of poles, are disposed radially outside the connection portion. The connection portion and the magnetic pole portions are integrated with each other. The permanent magnets are disposed between the magnetic pole portions. The magnetic pole portions include flange portions that cover parts of radially outer surfaces of the permanent magnets while allowing at least parts of the radially outer surfaces to be exposed. Each of the permanent magnets includes a tapered portion in at least a part thereof, and the tapered portion has a length in a direction perpendicular to the radial direction that decreases radially inward.
US08860264B2 Linear vibrator
There is provided a linear vibrator, including a fixed part having an inner space of a predetermined size formed therein; at least one magnet disposed in the inner space and generating magnetic force; a vibration part including a coil disposed to face the magnet to generate electromagnetic force through interaction therewith, and a mass body; a substrate having one end connected to the vibration part to serve as a free end, and the other end connected to the fixed part to serve as a fixed end; and a connection protrusion formed on the fixed part and inserted into a connection hole formed in the substrate so as to allow the substrate to be fixed to the fixed part.
US08860263B2 Linear vibration motor
Disclosed herein is a linear vibration motor including: a stator part including a coil, a printed circuit board coupled to the coil, a bracket having the printed circuit board fixedly coupled thereto, and a case having an internal space formed therein and coupled to the bracket; and a vibrator part including a main magnet positioned to face the coil, a yoke coupled to the magnet, a weight body coupled to an outer peripheral surface of the yoke, and an elastic member having one end coupled to the case and the other end coupled to the yoke, wherein the stator part further includes sub-magnets, which are magnetic damping units, the sub-magnets being disposed to face the main magnet of the vibrator part and being mounted in the stator part so that surfaces thereof facing the main magnet have the same polarities as those of the main magnet.
US08860261B2 Actuator
An actuator according to an embodiment includes support mechanisms that are disposed in plural places of an output shaft in a longitudinal direction and support the output shaft in a linear direction and a rotation direction, a motor portion that is disposed in a longitudinal direction of the output shaft and drives the output shaft in the linear direction and the rotation direction, a first detecting portion that detects an angle of a rotation direction of the output shaft, and a second detecting portion that detects displacement of the direct direction of the output shaft.
US08860259B1 Auxiliary electrical power system
An auxiliary electrical power system includes a housing that has a top wall, a bottom wall and a perimeter wall attached to and extends between the top and bottom walls. A battery for storing an electric charge is mounted within the housing. An inverter is mounted within the housing and is electrically coupled to the battery. A power cord is electrically coupled to the inverter and extends through the housing. The power cord has a distal end with respect to the housing. The distal end comprises a female plug configured to supply electricity to an electrically powered device from the battery when the electrically powered device is plugged into the female plug.
US08860258B2 Control system
A control system has an input instrument that generates a signal indicating permission and prohibition of running of a load, a power-supply unit that is configured to supply driving power to the load when the load is permitted to run by an input signal from the input instrument, and to cut off the supply of the driving power to the load when the load is prohibited from running by the input signal, and a monitoring device that is configured to monitor the input instrument and the power-supply unit. The power-supply unit is configured to cut off the supply of the driving power to the load when monitoring result of the monitoring device indicates an abnormality of one of the input instrument and the power-supply unit. The control system is compatible with category 2 of ISO 13849-1.
US08860256B2 Domestic appliance, especially a dishwasher or washer
A domestic appliance having a control device to control device components of the domestic appliance during execution of a program, wherein the device components have electrical loads. The domestic appliance also has a switch to at least partly de-energize the control device after the program has finished executing.
US08860255B2 Saturation control unit for an interphase transforming unit and PWM control apparatus for a voltage converting device
A saturation control unit for an interphase transforming unit is provided. The interphase transforming unit has a primary coil and a secondary coil which are magnetically coupled via a magnetic core member. The saturation control unit includes a minimum detecting unit and a maximum detecting unit. The minimum detecting unit detects a minimum value of a magnetizing current of the interphase transforming. The maximum detecting unit detects a maximum value of the magnetizing current. A saturation estimating unit is provided for estimating an offset value of the magnetizing current. A saturation control signal generating unit is provided for generating a saturation control signal for the interphase transforming unit based on the detected minimum value, the detected maximum value, and the estimated offset value.
US08860254B2 Power feeding apparatus and wireless power feeding system
Disclosed herein is a power feeding apparatus, including: a power feeding portion adapted to feed an electric power in a wireless manner; and a storage body storing therein the power feeding portion. The storage body includes a main body, a first storage portion formed within the main body and storing therein the power feeding portion, and at least one second storage portion formed so as to be adapted to store or retrieve a power receiving apparatus as a storage object in or from the main body, the electric power of the power feeding portion stored in the first storage portion being adapted to be fed from the at least one second storage portion. At least a magnetically shielding portion is formed in an outer peripheral portion, and the at least one second storage portion forms a magnetically closed space in a state of being stored in the main body.
US08860253B2 Power control system
To provide a power control system which evaluates an applied control pattern over a period of a certain length or more, so as to be used for the subsequent control with a configuration in which a discharge start time and output of an electric storage device are changed.
US08860250B2 Portable power devices and methods of supplying power
A portable power supplying system includes an enclosure including at least one wheel mounted to a bottom portion of the enclosure, a battery secured within the enclosure, and a battery charger secured within the enclosure. The battery charger is electrically connected to the battery for charging the battery. The system further includes a DC/AC inverter secured within the enclosure. The DC/AC inverter is electrically connected to the battery, and is configured to convert a direct current supplied by the battery to an alternating current. The system further includes a power outlet including at least one female household electrical connection, and a transfer switch secured within the enclosure. The transfer switch is electrically connected to the DC/AC inverter, the battery charger, the power outlet and a power source input.
US08860249B2 Power allocation to downhole tools in a bottom hole assembly
The present disclosure relates to a method to allocate electrical power among tools in a bottomhole assembly disposed in a wellbore. A bottomhole assembly having an electric generator, an electrical bus, a bus master, and two or more tools is provided. One or more of the two or more tools has selectable power modes. Electrical power, up to a maximum output value, is provided through the electrical bus to the two or more tools using the electric generator. Electronic components of the two or more tools are synchronized, using the bus master to select a normal power mode or a low power mode for each tool having selectable power modes. The combined power requirements of the two or more tools at any given time do not exceed the maximum output value.
US08860246B2 Systems and methods to balance solar panels in a multi-panel system
Systems and methods to balance currents among a plurality of photovoltaic units connected in series. In aspect, a management unit is coupled between a photovoltaic energy production unit and a string of energy production units. The management unit has an energy storage element (e.g., a capacitor) connected to the photovoltaic energy production unit. The management unit further has a switch to selectively couple to the energy storage element and the photovoltaic energy production unit to the string. The management unit allows the current in the string to be larger than the current in the photovoltaic energy production unit.
US08860245B2 Optimal utilization of power converters based on thermal characteristics
A method and system for utilization of power converters in an aircraft engine start system includes measurement of power converter operation data that is utilized with a mathematical model of the power converter thermal characteristics to calculate operation limits for subsequent start duty cycles. A warning indicator is utilized in the event the start duty cycle limits are exceeded. This invention can be extended for any More Electric Vehicle applications, which utilizes an electric engine start system.
US08860244B2 Vehicle power supply apparatus
There is provided a vehicle power supply apparatus which includes a battery charged by a generator and supplies, to a plurality of loads, electric power discharged by the battery and electric power generated by the generator. The apparatus includes an electric double layer capacitor connected in parallel to the battery, and a connection circuit for switching connection and disconnection between respective homopolar terminals of the battery and the electric double layer capacitor. The connection circuit is connected to charge the electric double layer capacitor based on a potential difference between terminals of the connection circuit. The plurality of loads include loads each of which generates a rush current of a predetermined value or more and each of which is fed electric power outputted by the electric double layer capacitor.
US08860242B1 Power-line communication coupling
In some embodiments, a system includes a power system coupled to a power bus, and a power line communication (PLC) gateway coupled in series with the power bus. In other embodiments, a system includes first and second power circuits coupled in series with a power bus, and first and second power-line communication circuits coupled in series with the power bus. In additional embodiments, a system includes a power converter coupled to a power bus and having one or more switching frequencies, and a power-line communication circuit coupled to the power bus and having one or more communication frequencies, where at least one of the switching frequencies is substantially greater than at least one of the communication frequencies.
US08860239B2 Wind or water energy installation
A wind or water energy installation for generating electrical energy, an installation having at least one propeller and at least one generator including at least one rotor, at least one stator and at least one magnetic circuit generating a magnetic flux. The at least one magnetic circuit has at least one magnet on the stator side and at least one coil on the stator side, through which at least part of the magnetic flux of the stator-side magnet flows, and the magnetic circuit is closed by the rotor which has a magnetic resistance (Rm) dependent on its respective rotational angle, on its surface facing the stator, such that the size of the magnetic flux in the at least one stator-side coil depends on the respective rotational angle of the rotor and changes when the rotor rotates.
US08860238B2 Method and device for handling, in particular for repairing or replacing, busbars on wind power plants
A method for handling busbars on wind power plants in which a power connection between a generator device disposed in an upper region of the wind power plant and a substation located at a base area of the wind power plant consists of a plurality of busbar subregions each comprising a certain number of mutually interconnected busbars.
US08860233B2 Resin composition for encapsulation and semiconductor unit encapsulated with resin
A resin composition for encapsulation, which contains 100 parts by weight of a synthetic resin, 10 to 500 parts by weight of a carbon precursor having a volume resistivity of 102 to 1010 Ω·cm, 0 to 60 parts by weight of a conductive filler having a volume resistivity lower than 102 Ω·cm and 100 to 1,500 parts by weight of an other inorganic filler.
US08860229B1 Hybrid bonding with through substrate via (TSV)
Embodiments of forming a semiconductor device structure are provided. The semiconductor device structure includes a first semiconductor wafer and a second semiconductor wafer bonded via a hybrid bonding structure, and the hybrid bonding structure includes a first conductive material embedded in a polymer material and a second conductive material embedded in a second polymer material. The first conductive material of the first semiconductor wafer bonded to the second conductive material of the second semiconductor wafer and the first polymer material of the first semiconductor wafer is bonded to the second polymer material of the second semiconductor wafer. The semiconductor device structure further includes at least one through substrate via (TSV) extending from a bottom surface of the second semiconductor wafer to a top surface of the first semiconductor wafer.
US08860224B2 Preventing the cracking of passivation layers on ultra-thick metals
A device includes a top metal layer; a UTM line over the top metal layer and having a first thickness; and a passivation layer over the UTM line and having a second thickness. A ratio of the second thickness to the first thickness is less than about 0.33.
US08860221B2 Electrode connecting structures containing copper
Provided are electrode-connecting structures or semiconductor devices, including a lower device including a lower substrate, a lower insulating layer formed on the lower substrate, and a lower electrode structure formed in the lower insulating layer, wherein the lower electrode structure includes a lower electrode barrier layer and a lower metal electrode formed on the lower electrode barrier layer, and an upper device including an upper substrate, an upper insulating layer formed under the upper substrate, and an upper electrode structure formed in the upper insulating layer, wherein the upper electrode structure includes an upper electrode barrier layer extending from the inside of the upper insulating layer under a bottom surface thereof and an upper metal electrode formed on the upper electrode barrier layer. The lower metal electrode is in direct contact with the upper metal electrode.
US08860220B2 Semiconductor device and method for manufacturing the same
An ultrasonic welding tool is used to bond end portions of an external connection terminal to circuit patterns of an insulating substrate, with a Vickers hardness not lower than 90. Bonding end portions are provided integrally with a bar in the external connection terminal. A bonding end portion located substantially in the lengthwise center of the bar is bonded first, then others are bonded alternately in order toward either end. Hardness of the bonding end portions is increased so that strength of the ultrasonic welding portions is increased, and displacement of the bonding end portion in either end from its regular position is suppressed to keep bonding strength high. Bonding strength of the ultrasonic welding portions between the external connection terminal and the circuit patterns of the insulating substrate can be increased so that long-term reliability can be secured in a semiconductor device.
US08860219B2 Chip assembly and chip assembling method
A chip assembly includes a PCB and a chip positioned on the PCB. The PCB includes a number of first bonding pads. Each bonding pad includes two soldering balls formed thereon. The chip includes a number of second bonding pads, and each second bonding pad corresponds to a respective first bonding pad. The two soldering balls of each first bonding pad are electrically connected to a corresponding second bonding pad via two bonding wires, and the bonding wires are bonded to the second corresponding bonding pad by a wedge bonding manner.
US08860212B1 Fluid cooled semiconductor die package
A fluid cooled semiconductor die package includes a package support substrate with a die mounting surface and an opposite package mounting surface. The package support substrate has external connector solder deposits on respective external connector pads of the package mounting surface, and a package fluid inlet duct and a package fluid outlet duct each providing fluid communication between the die mounting surface and package mounting surface. A semiconductor die is mounted on the die mounting surface. The die has external terminals electrically connected to the external connector pads. An inlet solder deposit is soldered to an inlet pad of the package mounting surface. The inlet pad surrounds an entrance of the fluid inlet duct. An outlet solder deposit is soldered to an outlet pad of the package mounting surface. The outlet pad surrounds an exit of the package fluid inlet duct.
US08860210B2 Semiconductor device
Disclosed is a semiconductor device that can properly relax a stress produced by a difference in coefficient of linear expansion between an insulating substrate and a cooler and can properly remove heat by cooling of a semiconductor element. A semiconductor device comprises an insulating substrate, a semiconductor element provided on the insulating substrate, a cooler, and a porous metal plate provided between the insulating substrate and the cooler. Through holes in the porous metal plate are open at least to that surface of the porous metal plate which faces the cooler. The sectional size of the pores decreases gradually from the cooler side toward the insulating substrate side.
US08860209B1 LED luminaire having front and rear convective heat sinks
Disclosed is a luminaire, comprising a front convective heat sink, a rear convective heat sink, and a removable thin printed circuit board. The front convective heat sink has at least one optical aperture. The removable thin printed circuit board has an electrically-insulated back surface and a selectively electrically-insulated front surface. The front surface has exposed electrical contacts in at least one area corresponding to the at least one optical aperture. The removable thin printed circuit board is sandwiched between the front and rear convective heat sinks with a compressive force.
US08860208B2 Heat spreader structures in scribe lines
An integrated circuit structure includes a first chip including a first edge; and a second chip having a second edge facing the first edge. A scribe line is between and adjoining the first edge and the second edge. A heat spreader includes a portion in the scribe line, wherein the heat spreader includes a plurality of vias and a plurality of metal lines. The portion of the heat spreader in the scribe line has a second length at least close to, or greater than, a first length of the first edge.
US08860207B2 Method of fabricating land grid array semiconductor package
A fan-out wafer level package is provided with a semiconductor die embedded in a reconstituted wafer. A redistribution layer is positioned over the semiconductor die, and includes a land grid array on a face of the package. A copper heat spreader is formed in the redistribution layer over the die in a same layer as a plurality of electrical traces configured to couple circuit pads of the semiconductor die to respective contact lands of the land grid array. In operation, the heat spreader improves efficiency of heat transfer from the die to the circuit board.
US08860205B2 Method of stiffening coreless package substrate
Embodiments of the present invention relate to a method of stiffening a semiconductor coreless package substrate to improve rigidity and resistance against warpage. An embodiment of the method comprises disposing a sacrificial mask on a plurality of contact pads on a second level interconnect (package-to-board interconnect) side of a coreless package substrate, forming a molded stiffener around the sacrificial mask without increasing the effective thickness of the substrate, and removing the sacrificial mask to form a plurality of cavities in the molded stiffener corresponding to the contact pads. Embodiments also include plating the surface of the contact pads and the sidewalls of the cavities in the molded cavities with an electrically conductive material.
US08860201B1 Stacked integrated circuit package using a window substrate
An integrated circuit (IC) package including a substrate, a first IC, and a second IC adjacent to the first IC. The substrate includes first and second surfaces respectively having first and second bond pads, and an opening offset relative to a center of the substrate and extending from the first surface to the second surface. The first IC includes a third surface having third bond pads accessible through the opening. The second IC includes fourth and fifth surfaces respectively having fourth and fifth bond pads. The third and fifth surfaces are attached to the second surface. At least one of the third bond pads is connected to at least one of the first bond pads using one or more bond wires extending through the opening. At least one of the fourth bond pads is connected to at least one of the second bond pads using one or more bond wires.
US08860198B2 Semiconductor package with temperature sensor
According to an exemplary embodiment, a dual compartment semiconductor package includes a conductive clip having first and second compartments. The first compartment is electrically and mechanically connected to a top surface of the first die. The second compartment electrically and mechanically connected to a top surface of a second die. The dual compartment semiconductor package also includes a groove formed between the first and second compartments, the groove preventing contact between the first and second dies. The dual compartment package electrically connects the top surface of the first die to the top surface of the second die. The first die can include an insulated-gate bipolar transistor (IGBT) and the second die can include a diode. A temperature sensor can be situated adjacent to, over, or within the groove for measuring a temperature of the dual compartment semiconductor package.
US08860197B2 Integrated circuits secure from invasion and methods of manufacturing the same
An integrated circuit device that is secure from invasion and related methods are disclosed herein. Other embodiments are also disclosed herein.
US08860196B2 Semiconductor package and method of fabricating the same
A semiconductor package and a method of manufacturing the same, and more particularly, to a package of a power module semiconductor and a method of manufacturing the same. The semiconductor package includes a substrate including a plurality of conductive patterns spaced apart from one another; a plurality of semiconductor chips disposed on the conductive patterns; a connecting member for electrically connecting the conductive patterns to each other, for electrically connecting the semiconductor chips to each other, or for electrically connecting the conductive pattern and the semiconductor chip; and a sealing member for covering the substrate, the semiconductor chips, and the connecting member, wherein a lower surface of the substrate and an upper surface of the connecting member are exposed to the outside by the sealing member.
US08860193B2 Pad configurations for an electronic package assembly
Embodiments of the present disclosure provide an electronic package assembly comprising a solder mask layer, the solder mask layer having at least one opening, and a plurality of pads coupled to the solder mask layer, wherein at least one pad of the plurality of pads includes (i) a first side, (ii) a second side, the first side being disposed opposite to the second side, (iii) a terminal portion and (iv) an extended portion, wherein the first side at the terminal portion is configured to receive a package interconnect structure through the at least one opening in the solder mask layer, the package interconnect structure to route electrical signals between a die and another electronic device that is external to the electronic package assembly, and wherein the second side at the extended portion is configured to receive one or more electrical connections from the die. Other embodiments may be described and/or claimed.
US08860190B2 Semiconductor device
According to one embodiment, a semiconductor device includes a circuit substrate, a semiconductor element, a sealing resin layer, and a conductive shielding layer. The circuit substrate includes an insulating layer, a plurality of interconnections forming first interconnection layers provided on an upper surface side of the insulating layer, a plurality of interconnections forming second interconnection layers provided on a lower surface side of the insulating layer, and a plurality of vias penetrating from the upper surface to the lower surface of the insulating layer. The semiconductor element is mounted on the upper surface side of the circuit substrate. The conductive shielding layer covers the sealing resin layer and part of an end portion of the circuit substrate. Any of the plurality of vias and the conductive shielding layer are electrically connected.
US08860184B2 Spacer assisted pitch division lithography
Spacer-based pitch division lithography techniques are disclosed that realize pitches with both variable line widths and variable space widths, using a single spacer deposition. The resulting feature pitches can be at or below the resolution limit of the exposure system being used, but they need not be, and may be further reduced (e.g., halved) as many times as desired with subsequent spacer formation and pattern transfer processes as described herein. Such spacer-based pitch division techniques can be used, for instance, to define narrow conductive runs, metal gates and other such small features at a pitch smaller than the original backbone pattern.
US08860182B1 Resistance random access memory device
A resistance random access memory device according to an embodiment includes a first electrode, a second electrode and a variable resistance film provided between the first electrode and the second electrode. The second electrode includes material selected from the group consisting of silver, copper, zinc, gold, titanium, nickel, cobalt, tantalum, aluminum, and bismuth, alloys thereof, and silicides thereof. The variable resistance film includes silicon oxynitride. The variable resistance film includes a first resistance change layer having a first nitrogen concentration and a second resistance change layer having a second nitrogen concentration lower than the first nitrogen concentration.
US08860178B2 Semiconductor device having an inductor
A semiconductor device is provided with a semiconductor chip. The semiconductor chip has a semiconductor substrate, an interconnect layer, an inductor and conductive pads (first pads). The interconnect layer is provided on the semiconductor substrate. The interconnect layer includes the inductor. The pads are provided on the interconnect layer. The pads are provided in a region within a circuit forming region of the semiconductor chip, which does not overlap the inductor.
US08860172B2 High voltage semiconductor device
An n well region and an n−region surrounding the n well region are provided in the surface layer of a p−silicon substrate. The n−region includes breakdown voltage regions in which high voltage MOSFETs are disposed. The n well region includes a logic circuit region in which a logic circuit is disposed. A p− opening portion is provided between a drain region of each high voltage MOSFET and the logic circuit region. An n buffer region used as load resistances is provided between a second pick-up region and the drain region. The p−opening portion is provided between the n buffer region and logic circuit region. By so doing, it is possible to realize a reduction in the area of chips, and provide a high voltage semiconductor device having a level shift circuit with a high switching response speed.
US08860171B2 Semiconductor device having diode characteristic
According to one embodiment, a semiconductor device is provided. The semiconductor device has a first region formed of semiconductor and a second region formed of semiconductor which borders the first region. An electrode is formed to be in ohmic-connection with the first region. A third region is formed to sandwich the first region. A first potential difference is produced between the first and the second regions in a thermal equilibrium state, according to a second potential difference between the third region and the first region.
US08860169B2 Semiconductor device comprising a Schottky barrier diode
The present invention aims to enhance the reliability of a semiconductor device equipped with a Schottky barrier diode within the same chip, and its manufacturing technology. The semiconductor device includes an n-type n-well region formed over a p-type semiconductor substrate, an n-type cathode region formed in part thereof and higher in impurity concentration than the n-well region, a p-type guard ring region formed so as to surround the n-type cathode region, an anode conductor film formed so as to integrally cover the n-type cathode region and the p-type guard ring region and to be electrically coupled thereto, n-type cathode conduction regions formed outside the p-type guard ring region with each separation portion left therebetween, and a cathode conductor film formed so as to cover the n-type cathode conduction regions and to be electrically coupled thereto. The anode conductor film and the n-type cathode region are Schottky-coupled to each other.
US08860167B2 Image sensor and method for manufacturing the same
An image sensor may include a semiconductor substrate, a plurality of light receiving devices formed within the semiconductor substrate, and a plurality of device isolation films for isolating the light receiving devices from each other. When an arrangement direction of a pixel array may be formed by arranging the light receiving devices is a horizontal direction, the pixel array may be formed by alternately arranging a first type light receiving device and a second type light receiving device having different horizontal lengths.
US08860162B2 Optoelectronic device with heat spreader unit
A solar module includes a solar cell, a heat spreader layer disposed above the solar cell, and a cell interconnect disposed above the solar cell. From a top-down perspective, the heat spreader layer at least partially surrounds an exposed portion of the cell interconnect.
US08860159B2 Spintronic electronic device and circuits
A spintronic electronic apparatus having a multilayer structure. The apparatus includes a substrate, having disposed in succession upon the substrate; a bottom interface layer; a pinned layer; a tunneling barrier; a free layer; and a top interface layer, wherein the apparatus operates as a non-resonant magnetic tunnel junction in a large amplitude, out-of-plane magnetization precession regime having weakly current dependent, large diode volt-watt sensitivity when external microwave signals that exceed a predetermined threshold current and have a frequency that is lower than a predetermined level excite the magnetization precession.
US08860158B2 High speed STT-MRAM with orthogonal pinned layer
A STTMRAM element includes a magnetization layer made of a first free layer and a second free layer, separated by a non-magnetic separation layer (NMSL), with the first and second free layers each having in-plane magnetizations that act on each other through anti-parallel coupling. The direction of the magnetization of the first and second free layers each is in-plane prior to the application of electrical current to the STTMRAM element and thereafter, the direction of magnetization of the second free layer becomes substantially titled out-of-plane and the direction of magnetization of the first free layer switches. Upon electrical current being discontinued to the STTMRAM element, the direction of magnetization of the second free layer remains in a direction that is substantially opposite to that of the first free layer.
US08860157B2 Memory cell with phonon-blocking insulating layer
An apparatus and associated method for a non-volatile memory cell with a phonon-blocking insulating layer. In accordance with various embodiments, a magnetic stack has a tunnel junction, ferromagnetic free layer, pinned layer, and an insulating layer that is constructed of an electrically and thermally insulative material that blocks phonons while allowing electrical transmission through at least one conductive feature.
US08860154B2 CMOS compatible silicon differential condenser microphone and method for manufacturing the same
The present invention provides a CMOS compatible silicon differential condenser microphone and a method of manufacturing the same. Said microphone comprises a silicon substrate, wherein a CMOS circuitry is accommodated thereon; a first rigid conductive perforated backplate supported on the silicon substrate with an insulating layer inserted therebetween; a second rigid perforated backplate formed above the first backplate, including CMOS passivation layers and a metal layer sandwiched between the CMOS passivation layers as an electrode plate of the second plate, wherein an air gap, with a spacer forming its boundary, is provided between the opposite perforated areas of the first backplate and the second backplate; a compliant diaphragm provided between the first backplate and the second backplate, wherein a back hole is formed to be open in the silicon substrate underneath the first backplate so as to allow sound pass through, and the diaphragm and the first backplate form a first variable condenser, the diaphragm and the second backplate form a second variable condenser, and the first variable condenser and the second variable condenser form differential condensers.
US08860135B2 Semiconductor structure having aluminum layer with high reflectivity
A method for filling a trench with a metal layer is disclosed. A deposition apparatus having a plurality of supporting pins is provided. A substrate and a dielectric layer disposed thereon are provided. The dielectric layer has a trench. A first deposition process is performed immediately after the substrate is placed on the supporting pins to form a metal layer in the trench, wherein during the first deposition process a temperature of the substrate is gradually increased to reach a predetermined temperature. When the temperature of the substrate reaches the predetermined temperature, a second deposition process is performed to completely fill the trench with the metal layer. The present invention further provides a semiconductor device having an aluminum layer with a reflectivity greater than 1, wherein the semiconductor device is formed by using the method.
US08860134B1 Trench power device and manufacturing method thereof
A trench power device includes a semiconductor layer, a trench gate structure, a trench source structure, and a contact. The semiconductor layer has an epitaxial layer, a doped body region, a S/D region, and a doped contact-carrying region. The doped body region is formed in the epitaxial layer, the S/D region is formed in the doped body region, and the doped contact-carrying region is formed in the doped body region and outside a projecting portion defined by orthogonally projecting from the S/D region to the doped body region. The trench gate structure is embedded in the S/D region, the doped body region, and the epitaxial layer. The trench source structure is embedded in the doped body region and the epitaxial layer, and is connected to the doped contact-carrying region. The contact is connected to the S/D region and the doped contact-carrying region.
US08860129B2 Semiconductor device
Provided is a semiconductor device in which on-resistance is largely reduced. The semiconductor device includes an n type epitaxial layer in which each region between neighboring trenches becomes a channel, and a plurality of embedded electrodes each of which is formed on an inner surface of each trench via a silicon oxide film. By blocking each region between neighboring trenches with every depletion layer formed around each of trenches, current flowing through each region between the neighboring trenches is interrupted. By deleting every depletion layer formed around each of the trenches, current can flow through each region between the neighboring trenches.
US08860127B2 Vertical channel transistor with self-aligned gate electrode and method for fabricating the same
A method for fabricating vertical channel transistors includes forming a plurality of pillars which have laterally opposing both sidewalls, over a substrate; forming a gate dielectric layer on both sidewalls of the pillars; forming first gate electrodes which cover any one sidewalls of the pillars and shield gate electrodes which cover the other sidewalls of the pillars and have a height lower than the first gate electrodes, over the gate dielectric layer; and forming second gate electrodes which are connected with upper portions of sidewalls of the first gate electrodes.
US08860125B2 Nonvolatile semiconductor memory device and method of manufacturing the same
According to one embodiment, a memory device includes a semiconductor substrate, first, second, third and fourth fin-type stacked layer structures, each having memory strings stacked in a first direction perpendicular to a surface of the semiconductor substrate, and each extending to a second direction parallel to the surface of the semiconductor substrate, a first part connected to first ends in the second direction of the first and second fin-type stacked layer structures each other, a second part connected to first ends in the second direction of the third and fourth fin-type stacked layer structures each other, a third part connected to second ends in the second direction of the first and third fin-type stacked layer structures each other, and a fourth part connected to second ends in the second direction of the second and fourth fin-type stacked layer structures each other.
US08860114B2 Structure and method for a fishbone differential capacitor
The present disclosure provides an integrated circuit. The integrated circuit includes a substrate having a surface that is defined by a first axis and a second axis perpendicular to the first axis; and a capacitor structure disposed on the substrate. The capacitor structure includes a first conductive component; a second conductive component and a third conductive component symmetrically configured on opposite sides of the first conductive component. The first, second and third conductive components are separated from each other by respective dielectric material.
US08860111B2 Phase change memory cell array with self-converged bottom electrode and method for manufacturing
An array of phase change memory cells is manufactured by forming a separation layer over an array of contacts, forming a patterning layer on the separation layer and forming an array of mask openings in the patterning layer using lithographic process. Etch masks are formed within the mask openings by a process that compensates for variation in the size of the mask openings that result from the lithographic process. The etch masks are used to etch through the separation layer to define an array of electrode openings exposing the underlying contacts. Electrode material is deposited within the electrode openings; and memory elements are formed over the bottom electrodes. Finally, bit lines are formed over the memory elements to complete the memory cells. In the resulting memory array, the critical dimension of the top surface of bottom electrode varies less than the width of the memory elements in the mask openings.
US08860109B2 Capacitor-less memory device
Provided is a capacitorless memory device. The device includes a semiconductor substrate, an insulating layer disposed on the semiconductor substrate, a storage region disposed on a partial region of the insulating layer, a channel region disposed on the storage region to provide a valence band energy offset between the channel region and the storage region, a gate insulating layer and a gate electrode sequentially disposed on the channel region, and source and drain regions connected to the channel region and disposed at both sides of the gate electrode. A storage region having different valence band energy from a channel region is disposed under the channel region unit so that charges trapped in the storage region unit cannot be easily drained. Thus, a charge retention time may be increased to improve data storage capability.
US08860108B2 Oxide-based thin-film transistor (TFT) semiconductor memory device having source/drain electrode of one transistor connected to gate electrode of the other
It is an object to provide a semiconductor having a novel structure. In the semiconductor device, a plurality of memory elements are connected in series and each of the plurality of memory elements includes first to third transistors thus forming a memory circuit. A source or a drain of a first transistor which includes an oxide semiconductor layer is in electrical contact with a gate of one of a second and a third transistor. The extremely low off current of a first transistor containing the oxide semiconductor layer allows storing, for long periods of time, electrical charges in the gate electrode of one of the second and the third transistor, whereby a substantially permanent memory effect can be obtained. The second and the third transistors which do not contain an oxide semiconductor layer allow high-speed operations when using the memory circuit.
US08860102B2 Solid state imaging device and imaging apparatus
A solid-state imaging device has, in a semiconductor substrate, plural PDs arranged two-dimensionally and signal reading circuits which are formed as MOS transistors and read out signals corresponding to charges generated in the respective PDs. Microlenses for focusing light beams are formed over the respective PDs. An interlayer insulating film in which interconnections are buried is formed as an insulating layer between the semiconductor substrate and the microlenses. Closed-wall-shaped structures are formed in the interlayer insulating film so as to surround parts of focusing optical paths of the microlenses, respectively. The structures are made of a nonconductive material that is different in refractive index from a material of what is formed around them.
US08860101B2 Image sensor cross-talk reduction system
A system and method for reducing cross-talk between photosensitive diodes is provided. In an embodiment an isolation region comprising a first concentration of dopants is located between the photosensitive diodes. The photosensitive diodes have a second concentration of dopants that is less than the first concentration of dopants, which helps to prevent diffusion from the photosensitive diodes to form a potential path for undesired cross-talk between the photosensitive diodes.
US08860100B2 Solid-state imaging device
A solid-state imaging device includes: a first photodiode receiving light of a first color; a second photodiode that is arranged next to the first photodiode in a first direction and receives light of a second color; a third photodiode that is arranged next to the second photodiode in a second direction and receives light of the first color; a fourth photodiode that is arranged next to the third photodiode in the first direction and receives light of a third color; a first reset transistor for discharging a charge generated in the first photodiode and the second photodiode; and a second reset transistor for discharging a charge generated in the third photodiode and the fourth photodiode. The first photodiode and the third photodiode have a small difference in area.
US08860087B2 Nitride semiconductor device and manufacturing method thereof
The present invention relates to a nitride semiconductor device and a manufacturing method thereof. According to one aspect of the present invention, a nitride semiconductor device including: a nitride semiconductor layer having a 2DEG channel; a source electrode in ohmic contact with the nitride semiconductor layer; a drain electrode in ohmic contact with the nitride semiconductor layer; a plurality of p-type nitride semiconductor segments formed on the nitride semiconductor layer and each formed lengthways from a first sidewall thereof, which is spaced apart from the source electrode, to a drain side; and a gate electrode formed to be close to the source electrode and in contact with the nitride semiconductor layer between the plurality of p-type semiconductor segments and portions of the p-type semiconductor segments extending in the direction of a source-side sidewall of the gate electrode aligned with the first sidewalls of the p-type nitride semiconductor segments is provided.
US08860082B2 Transient voltage suppressor circuit, and diode device therefor and manufacturing method thereof
The present invention discloses a transient voltage suppressor (TVS) circuit, and a diode device therefor and a manufacturing method thereof. The TVS circuit is for coupling to a protected circuit to limit amplitude of a transient voltage which is inputted to the protected circuit. The TVS circuit includes a suppressor device and at least a diode device. The diode device is formed in a substrate, which includes: a well formed in the substrate; a separation region formed beneath the upper surface; a anode region and a cathode region, which are formed at two sides of the separation region beneath the upper surface respectively, wherein the anode region and the cathode region are separated by the separation region; and a buried layer, which is formed in the substrate below the well with a higher impurity density and a same conductive type as the well.
US08860081B2 Semiconductor device
To improve the performance of a protection circuit including a diode formed using a semiconductor film. A protection circuit is inserted between two input/output terminals. The protection circuit includes a diode which is formed over an insulating surface and is formed using a semiconductor film. Contact holes for connecting an n-type impurity region and a p-type impurity region of the diode to a first conductive film in the protection circuit are distributed over the entire impurity regions. Further, contact holes for connecting the first conductive film and a second conductive film in the protection circuit are dispersively formed over the semiconductor film. By forming the contact holes in this manner, wiring resistance between the diode and a terminal can be reduced and the entire semiconductor film of the diode can be effectively serve as a rectifier element.
US08860072B2 Light emitting device and light unit having the same
A light emitting device includes a body having a first recess; a barrier section having a second recess and a third recess, protruding upward over a bottom surface of the first recess, and dividing the bottom surface of the first recess into a first region and a second region; a first light emitting diode disposed in the first region; a second light emitting diode disposed in the second region; a first lead electrode disposed in the first region; a second lead electrode disposed in the second region; a first wire electrically connecting the first lead electrode to the second light emitting diode through the second recess; and a second wire electrically connecting the second lead electrode to the first light emitting diode through the third recess.
US08860070B2 Vertical gallium nitride-based light emitting diode and method of manufacturing the same
The present disclosure provides a vertical GaN-based semiconductor diode and a method of manufacturing the same. The GaN-based πi-V group semiconductor device includes a substrate, a p-type ohmic electrode layer on the substrate, a p-type GaN-based πi-V group compound semiconductor layer on the p-type ohmic electrode layer, an n-type GaN-based πi-V group compound semiconductor layer on the p-type GaN-based πi-V group compound semiconductor layer, and an n-type ohmic electrode layer on the n-type GaN-based IE-V group compound semiconductor layer. The p-type ohmic electrode layer is an Ag-based highly reflective electrode having a high reflectivity of 70% or more, and a surface of the n-type GaN-based E-V group compound semiconductor layer is subjected to at least one of a process of forming photonic crystals and a process of surface roughening.
US08860069B2 Light-emitting device package having a molding member with a low profile, and method of manufacturing the same
A light-emitting device package. The light-emitting device package includes a lead frame comprising a plurality of separate leads; a molding member that fixes the plurality of leads and comprises an opening portion that exposes the lead frame; and a light-emitting device chip that is attached on the lead frame in the opening portion and emits light through an upper surface portion of the light-emitting device chip, wherein a height of the molding member is lower than a height of the light-emitting device chip with respect to the lead frame.
US08860066B2 LED module
An LED module A1 includes an LED chip 1, a lead group 4 including a lead 4A on which the LED chip 1 is mounted and a lead 4B spaced apart from the lead 4A, a resin package 2 covering part of the lead group 4, and mounting terminals 41 and 42 provided by part of the lead group 4 that is exposed from the resin package 2 and spaced apart from each other in direction x. The LED module further includes a mounting terminal 43 spaced apart from the mounting terminal 41 in direction y, and a mounting terminal 44 spaced apart from the mounting terminal 42 in direction y. This arrangement allows the LED module A1 to be mounted at a correct position on a circuit board.
US08860064B2 Light emitting device
A light emitting device includes a light emitting element, a wire connected to the light emitting element, and a substrate supporting the light emitting element. The substrate is formed with a first recess and a second recess that are open in a common surface of the substrate. The first recess includes a first bottom surface and a first side surface connected to the first bottom surface, and the light emitting element is disposed on the first bottom surface. The second recess includes a second bottom surface and a second side surface connected to the second bottom surface, and the wire is bonded to the second bottom surface. Both of the first side surface and the second side surface reach the common surface. The first side surface is connected to both of the second bottom surface and the second side surface. The opening area of the first recess is larger than the opening area of the second recess.
US08860058B2 Solid state white light emitter and display using same
A light emitting assembly comprising a solid state device coupleable with a power supply constructed and arranged to power the solid state device to emit from the solid state device a first, relatively shorter wavelength radiation, and a down-converting luminophoric medium arranged in receiving relationship to said first, relatively shorter wavelength radiation, and which in exposure to said first, relatively shorter wavelength radiation, is excited to responsively emit second, relatively longer wavelength radiation. In a specific embodiment, monochromatic blue or UV light output from a light-emitting diode is down-converted to white light by packaging the diode with fluorescent organic and/or inorganic fluorescers and phosphors in a polymeric matrix.
US08860057B2 Light emitting device and manufacturing method of the same
The light emitting device 10 comprises a mounting substrate 11, LED chips 20 flip-chip bonded on the mounting substrate 11, and a glass sealing member 30 made of a plate-shaped glass material that seals the LED chips 20 formed on the mounting substrate 11. Here, the glass sealing member 30 is in a state in which fine voids are almost evenly dispersed and distributed between the powder grains of the glass material, and the powder grains are connected with each other, and the fine bumps/dips 30a are almost evenly dispersed and distributed on the surface of the glass sealing member 30.
US08860056B2 Structure and method for LED with phosphor coating
The present disclosure provides a light emitting diode (LED) apparatus. The LED apparatus includes an LED emitter having a top surface; and a phosphor feature disposed on the LED emitter. The phosphor feature includes a first phosphor film disposed on the top surface of the LED emitter and having a first dimension defined in a direction parallel to the top surface of the LED emitter; a second phosphor film disposed on the first phosphor film and having a second dimension defined in the direction; and the second dimension is substantially less than the first dimension.
US08860055B2 Light emitting device
A light emitting device according to the embodiment includes a first conductive semiconductor layer; an active layer under the first conductive semiconductor layer; a second conductive semiconductor layer under the active layer; a current blocking region under the second conductive semiconductor layer; a second electrode layer under the second conductive semiconductor layer and the current blocking region; and a first electrode layer including a protrusion protruding toward the first conductive semiconductor layer arranged, on the first conductive semiconductor layer.
US08860054B2 Electrooptical device and electronic apparatus
An electrooptical device includes a substrate, a pixel electrode which is provided on the substrate, a semiconductor element which is provided so as to correspond to the pixel electrode, and a light reflection portion formed with a groove formed on at least a part of the substrate. In the electrooptical device, the semiconductor element is arranged so as to overlap with the light reflection portion in plan view and is arranged on a flattened film provided so as to cover at least an opening of the groove.
US08860053B2 Light emitting module
A light emitting module includes: a light emitting element including: a first light emitting surface, and second light emitting surfaces bordering the first light emitting surface; an optical wavelength conversion member that converts a wavelength of light emitted from the light emitting element, wherein the optical wavelength conversion member is plate-shaped and is disposed such that an incident surface of the optical wavelength conversion member faces the first light emitting surface; and a reflecting member disposed to face the incident surface of the optical wavelength conversion member, the reflecting member comprising a reflecting surface. The reflecting surface faces the second light emitting surfaces, and the reflecting surface is inclined such that a distance between the reflecting surface and the second light emitting surfaces is gradually increased toward the incident surface of the optical wavelength conversion member.
US08860051B2 Textured phosphor conversion layer light emitting diode
This invention is related to LED Light Extraction for optoelectronic applications. More particularly the invention relates to (Al, Ga, In)N combined with optimized optics and phosphor layer for highly efficient (Al, Ga, In)N based light emitting diodes applications, and its fabrication method. A further extension is the general combination of a shaped high refractive index light extraction material combined with a shaped optical element.
US08860049B2 Multi-light emitting diode package
A multi-LED package includes a heat sink including a primary slug and a secondary slug separated from each other, a primary LED chip mounted on the primary slug, one or more secondary LED chips mounted on the secondary slug, a lead frame structure electrically wired to the primary and secondary LED chips, and a phosphor covering at least a part of the primary LED chip. Another multi-LED package includes a heat sink having an upper surface and partitions protruding therefrom, a primary LED chip mounted inside the partitions, one or more secondary LED chips mounted outside the partitions, a lead frame structure electrically wired to the primary and secondary LED chips, and a phosphor covering at least a part of the primary LED chip.
US08860042B2 Light module having metal clamps
A light component includes a printed circuit board and a plurality of lighting emitting diodes (LEDs). The printed circuit board has a metal substrate. The LEDs are disposed on the printed circuit board, wherein two opposite edges of the metal substrate protrude out and are bent towards the LEDs to form two metal clamps.
US08860032B2 Thin film transistor substrate, method of manufacturing the same, and display apparatus having the same which improve switching characteristics
A thin film transistor substrate that includes a substrate, first and second gate electrodes that are formed on the substrate, a gate insulating layer that is formed on the first and second gate electrodes, a first semiconductor and a second semiconductor that are formed on the gate insulating layer, and that overlap the first gate electrode and the second gate electrode, respectively, a first source electrode and a first drain electrode that are formed on the first semiconductor, and positioned opposed to and spaced from each other, a source electrode connected to the first drain electrode and a second drain electrode positioned opposed to and spaced from the second source electrode, wherein the second source and second drain electrodes are formed on the second semiconductor, and a pixel electrode that is electrically connected to the second drain electrode, a method of manufacturing the same, and a display apparatus having the same.
US08860031B2 Non-volatile semiconductor memory device and method of manufacturing the same
A non-volatile semiconductor memory device according to an embodiment includes a semiconductor substrate and a transistor provided on the semiconductor substrate. The transistor includes a conductive layer, a gate insulating layer, a semiconductor layer, and an oxidation layer. The conductive layer functions as a gate of the transistor. The gate insulating layer contacts with a side surface of the conductive layer. The semiconductor layer has a side surface sandwiching the gate insulating layer with the conductive layer, extends a direction perpendicular to the semiconductor substrate, and functions as a body of the transistor. The oxidation layer contacts with the other side surface of the semiconductor layer. The semiconductor layer is made of silicon germanium. The oxidation layer is made of a silicon oxide.
US08860022B2 Oxide semiconductor film and semiconductor device
A method for evaluating an oxide semiconductor film, a method for evaluating a transistor including an oxide semiconductor film, a transistor which includes an oxide semiconductor film and has favorable switching characteristics, and an oxide semiconductor film which is applicable to a transistor and enables the transistor to have favorable switching characteristics are provided. A PL spectrum of an oxide semiconductor film obtained by low-temperature PL spectroscopy has a first curve whose local maximum value is found in a range of 1.6 eV or more and 1.8 eV or less and a second curve whose local maximum value is found in a range of 1.7 eV or more and 2.4 eV or less. A value obtained by dividing the area of the second curve by the sum of the area of the first curve and the area of the second curve is 0.1 or more and less than 1.
US08860018B2 Anthanthrene based compound and semiconductor device
An anthanthrene based compound of the structural formula (1) is disclosed: wherein X represents an element of the Group 16; n represents an integer of from 0 to 20; m represents an integer of from 1 to 9; a bonding position in the A segment to the B segment, a bonding position in the B segment to the A segment, a bonding position in the B segment to the C segment, and a bonding position in the C segment to the B segment are at least one of from the 1-position to the 5-position and from the 7-position to the 11-position; and each of substituents R1, R2, R3, R4, R5, R7, R8, R9, R10 and R11 independently represents, for example, a substituent of one member selected from the group consisting of a hydrogen atom, an alkyl group, an aryl group, an arylalkyl group and the like.
US08860015B2 Organic light emitting display apparatus and method of manufacturing the same
The organic light emitting display apparatus includes a substrate; a gate electrode formed on the substrate; a source electrode and a drain electrode formed on the gate electrode to be insulated from the gate electrode; an active layer formed on the source electrode and the drain electrode and containing an organic semiconductor material, at least one region of the active layer overlapping with the gate electrode; a pixel defining layer formed on the active layer and including an aperture; an intermediate layer disposed to correspond to the aperture and including an organic emission layer; and an opposite electrode formed on the intermediate layer. One of the source electrode and the drain electrode is formed to be long to act as a pixel electrode and includes a first conductive layer and a second conductive layer on the first conductive layer, the second conductive layer formed to contact the intermediate layer.
US08860009B2 Device comprising positive hole injection transport layer, method for producing the same and ink for forming positive hole injection transport layer
A device having an easy production process and capable of achieving a long lifetime. The device has a substrate, two or more electrodes facing each other disposed on the substrate and a positive hole injection transport layer disposed between two electrodes among the two or more electrodes. The positive hole injection transport layer contains a reaction product of a molybdenum complex or tungsten complex.
US08860007B2 Aryl-substituted polyindenofluorenes for use in organic electroluminiscent devices
The invention relates to organic semiconductive polymers comprising a new backbone system, monomers for the preparation of such polymers, methods for the preparation of such polymers and the use of such polymers in organic optoelectronic devices.
US08860005B1 Thin light emitting diode and fabrication method
A method for fabrication a light emitting diode (LED) includes growing a crystalline LED structure on a growth substrate, forming alternating material layers on the LED structure to form a reflector on a back side opposite the growth substrate and depositing a stressor layer on the reflector. A handle substrate is adhered to the stressor layer. The LED structure is separated from the growth substrate using a spalling process to expose a front side of the LED structure.
US08860002B2 Limited maximum fields of electrode-switching layer interfaces in Re-RAM cells
Provided are ReRAM cells, each having at least one interface between an electrode and a resistive switching layers with a maximum field value of less than 0.25. The electrode materials forming such interfaces include tantalum nitrides doped with lanthanum, aluminum, erbium yttrium, or terbium (e.g., TaX(Dopant)YN, where X is at least about 0.95). The electrode materials have low work functions (e.g., less than about 4.5 eV). At the same time, the resistive switching materials have high relative dielectric permittivities (e.g., greater than about 30) and high electron affinities (greater than about for 3.5 eV). Niobium oxide is one example of a suitable resistive switching material. Another electrode interfacing the resistive switching layer may have different characteristics and, in some embodiments, may be an inert electrode.
US08859998B2 TEM sample preparation
An improved method of preparing ultra-thin TEM samples that combines backside thinning with an additional cleaning step to remove surface defects on the FIB-facing substrate surface. This additional step results in the creation of a cleaned, uniform “hardmask” that controls the ultimate results of the sample thinning, and allows for reliable and robust preparation of samples having thicknesses down to the 10 nm range.
US08859993B2 Sample holder of electron beam exposure apparatus and electron beam exposure method using the same
A sample holder to be disposed between an electrostatic chuck and a sample smaller than the upper surface of the electrostatic chuck is provided, the sample holder including: a base plate formed in the same size as the upper surface of the electrostatic chuck; a sample placement portion located on the upper surface of the base plate, and designed to place the sample thereon; and a circumferential portion being a portion of the upper surface of the base plate other than the sample placement portion, and having a conductive material exposed to the outside.
US08859992B2 Charged particle beam devices
In a charged particle beam device, such as an electron microscope, a beam generating apparatus generates a focussed charged particle beam e− that is incident on a specimen in a specimen chamber which holds the specimen in a gaseous environment. A pressure limiting aperture provides partial gaseous isolation of the specimen chamber from the beam generating means, and is located in a lens of the latter. The device includes a conduit, such as an intermediate chamber in the lens, through which, in use, gas is supplied to set up a flow of gas from the region of the lens towards the specimen, thereby to prevent material released from the specimen from impinging on the pressure limiting aperture, to prevent contamination of the latter. The device can be used in a method of scanning a specimen with a charged particle beam, for example in a method of electron microscopy.
US08859986B2 Ion generation using wetted porous material
The invention generally relates to systems and methods for mass spectrometry analysis of microorganisms in samples.
US08859985B2 Radiation detector, radiation detection apparatus, and X-ray analyzer
A radiation detector employed in a radiation detection apparatus and a fluorescent X-ray analyzer includes: a first circuit board on which a semiconductor radiation sensor is mounted and which is cooled by a Peltier device (an electronic cooling unit); and a second circuit board set apart from the first circuit board. A plurality of lead pins are joined to the second circuit board. Then, the first circuit board and the second circuit board are wire-bonded to each other. In comparison with conventional wire bonding performed onto the tips of lead pins, the work of connection is easy, the productivity is high, and the reliability of connection is high. Further, the second circuit board not requiring cooling is set apart so that cooling is concentrated on the first circuit board. This permits size reduction of the radiation detector.
US08859984B2 Method and apparatus for inspecting sample surface
Provided is a method and an apparatus for inspecting a sample surface with high accuracy. Provided is a method for inspecting a sample surface by using an electron beam method sample surface inspection apparatus, in which an electron beam generated by an electron gun of the electron beam method sample surface inspection apparatus is irradiated onto the sample surface, and secondary electrons emanating from the sample surface are formed into an image toward an electron detection plane of a detector for inspecting the sample surface, the method characterized in that a condition for forming the secondary electrons into an image on a detection plane of the detector is controlled such that a potential in the sample surface varies in dependence on an amount of the electron beam irradiated onto the sample surface.
US08859983B2 Method of and system for exposing a target
The invention relates to a method of exposing a target by means of a plurality of beamlets. First, a plurality of beamlets is provided. The beamlets are arranged in an array. Furthermore, a target to be exposed is provided. Subsequently, relative movement in a first direction between the plurality of beamlets and the target is created. Finally, the plurality of beamlets is moved in a second direction, such that each beamlet exposes a plurality of scan lines on the target. The relative movement in the first direction and the movement of the plurality of beamlets in the second direction are such that the distance between adjacent scan lines exposed by the plurality of beamlets is smaller than a projection pitch Pproj,X in the first direction between beamlets of the plurality of beamlets in the array.
US08859981B1 Method for autonomous self-blanking by radiation portal monitors to minimize the interference from pulsed X-rays radiation
A system and associated method for isolating intended radiation signals for determining target characteristics includes multiple detectors for detecting radiation signals having varying energies, delay modules for delaying the detected radiation signals and a discriminator associated with the multiple detectors for determining if detected radiation signals include unintended radiation signals, e.g., x-rays, and provided blanking signals to a switch in order to effectively remove the unintended radiation signals from the data that is presented to the processor for determining target characteristics.
US08859977B2 Wavefront measuring apparatus, wavefront measuring method, and computer-readable medium storing program
A wavefront measuring apparatus includes an optical element forming a periodic pattern by light, a detector having pixels to detect the light, and a computer computing, based on detection results of the detector, wavefront information at positions in a wavefront of the light transmitted through or reflected by a specimen. The detector detects a first periodic pattern formed by the light, and a second periodic pattern formed by the light and shifted in phase from the first periodic pattern. The computer computes the wavefront information at one of the positions by using a result detected in a first pixel of the pixels when detecting the first periodic pattern, a result detected in a second pixel of the pixels when detecting the first periodic pattern, the second pixel being positioned within three pixels from the first pixel, and a result detected in the first pixel when detecting the second periodic pattern.
US08859974B2 Adjustable spect detector
A SPECT detector system includes a plurality of detector units. Each detector unit includes a plurality of detector elements disposed in fixed positions with respect to one another. The detector units are adjustably positioned with respect to one another around a detector arc, which is placed adjacent to a patient.
US08859970B2 Terahertz wave generating device, camera, imaging device, and measurement device
A terahertz wave generating device includes a first light source, a second light source and an antenna. The first light source and a second light source are configured and arranged to generate pulsed lights. The antenna is configured and arranged to generate terahertz waves when irradiated by the pulsed lights generated by the first light source and the second light source. The antenna has a pair of electrodes arranged opposite each other with a gap being formed therebetween. The first light source and the second light source are configured and arranged to irradiate the pulsed lights between the electrodes at timings that are offset from each other.
US08859969B2 Optical analyzer for identification of materials using reflectance spectroscopy
A device and method for identifying solid and powdered materials use near-infrared reflection spectroscopy combined with multivariate calibration methods for analysis of the spectral data. Near-infrared reflection spectroscopy is employed within either the 700-1100 nm or the 900-1700 nm wavelength range to identify solid or powdered materials and determine whether they match specific known materials. Uses include identifying solid and powdered materials with a fast measurement cycle time of about 2 to 15 seconds and with a method that requires no sample preparation, as well as quantitative analysis to determine the concentration of one or more chemical components in a solid or powdered sample that consists of a mixture of components. A primary application involving identification analysis verification of the identify and purity of powdered materials used for fabricating drug tablets and capsules for quality control purposes.
US08859964B2 Electron microscope and method of adjusting the same
An electron microscope is offered which has a detector and a noise canceling circuit whose offset can be easily adjusted if any information about the offset of the detector is not available. Also, a method of adjusting this microscope is offered. The method of adjusting the electron microscope (1) starts with measuring the output voltage from a preamplifier (20) at given timing while blocking the electron beam transmitted through a sample (14) from hitting the detector (15) (step S140). An offset voltage to be set into the noise canceling circuit (30) is calculated based on the measured output voltage from the preamplifier (20) (step S150). The calculated offset voltage is set into the noise canceling circuit (30) (step S160).
US08859960B2 Method for transmitting ions and carrier gas between mutually facing curved electrodes
A method for transmitting ions entrained in a flowing carrier gas into and through a gap defined by a pair of mutually facing curved electrodes comprises: inputting the ions and flowing gas into the gap through an ion inlet orifice of a first one of the pair of electrodes, the ion inlet orifice comprising an orifice wall, an orifice inlet end and an orifice outlet end, the orifice wall being smoothly convexly curved between the inlet end and the outlet end, wherein a width of the gap and a flow rate of the carrier gas through the ion inlet orifice and gap are such that the gas flow is laminar within the ion inlet orifice and gap.
US08859959B2 Ion generation using wetted porous material
The invention generally relates to systems and methods for mass spectrometry analysis of samples. In certain embodiments, the invention provides a mass spectrometry probe including at least one porous material connected to a high voltage source, in which the porous material is discrete from a flow of solvent.
US08859955B2 Function switching with fast asynchronous acquisition
A method of analyzing a sample is disclosed comprising transmitting a first population of ions through a mass spectrometer and switching a state or mode of the mass spectrometer to produce a second population of ions. A sequential stream of mass spectra is acquired asynchronously with respect to switching the state or mode of the mass spectrometer. The stream of mass spectral data is then post-processed to produce mass spectra corresponding predominantly to the first and second population of ions.
US08859951B2 Method and apparatus for photosensor gain and scintillation crystal optical coupling monitoring in radiation detectors
A photosensor gain detection apparatus that includes a detector including a photosensor configured to output a signal. Also included in the apparatus is an after-pulse/dark-pulse detector device that detects an after-pulse or a dark-pulse in the signal output by the photosensor, and outputs an indication signal when the after-pulse or the dark-pulse is detected, the after-pulse and the dark-pulse representing after-events in the photosensor triggered from a previous photon generating event. The apparatus additionally includes an integrator device that integrates the signal output by the photosensor and to output an integrated signal, a histogram device connected to the integrator and the after-pulse/dark-pulse detector device, and that generates a histogram from the integrated signal and the indication signal, a gain determination device that determines a gain of the photosensor based on the generated histogram, and a memory configured to store the determined gain.
US08859941B2 Surface temperature cooking control
An oven includes an oven liner defined by front, top, bottom, back and side panels, a heating element thermally coupled to the oven liner, a temperature sensor configured to detect a temperature of a panel of the oven cavity, and a controller operatively coupled to the temperature sensor and the heating element. The controller is configured to energize the heating element as a function of the detected temperature.
US08859934B1 Methods for slag removal
A method of removing slag formed during laser cutting a hypotube may include flowing cooling gas into a laser nozzle, directing flow of the cooling gas onto an external surface of the hypotube, and injecting cooling fluid into an inner lumen of the hypotube at a velocity. Flowing the cooling gas and injecting the cooling fluid may at least partially remove slag from the external surface of the hypotube.
US08859932B2 Laser beam irradiation apparatus for substrate sealing, substrate sealing method, and method of manufacturing organic light emitting display device using the same
A laser beam irradiation apparatus and method of manufacturing an organic light emitting display device using the same are disclosed. The laser beam irradiation apparatus is configured to irradiate a laser beam to an object extending in a first direction while moving the laser beam relative to the object in the first direction, where the laser beam has a cross-section taken in a plane perpendicular to a second direction in which the laser beam is irradiated from the apparatus, the cross-section comprising two substantially symmetrical portions that are substantially symmetrical about a centerline of the cross-section extending in the first direction, where the cross-section has a centerline length taken in the centerline, where at least part of the substantially symmetrical portions has a length in the first direction that is longer than the centerline length.
US08859930B2 Thermal cutting machine
Adhesion and accumulation of spatter onto a covering member that encloses the outer periphery of a torch is minimized and flying of spatter is confined within a narrow area. To this end, a covering member for enclosing a specified angular range of the outer periphery of a plasma torch 9 is provided and an opening portion 35 is formed between every adjacent shielding plates 34 in the covering member.
US08859928B2 Multi-stage compressor in a plasma cutter
Systems and methods are provided for a torch power system using a multi-stage compressor. In one embodiment, a system includes a torch power unit that includes a compressor having multiple compression stages. A method of operation is provided that includes compressing a gas via a multi-stage compressor in a torch power unit. A method of manufacturing a torch power unit is provided that includes providing a multi-stage compressor for a torch power unit and mounting the multi-stage compressor inside an enclosure of the torch power unit. Another system is provided that includes a plasma cutting circuit, a multi-stage compressor, a motor coupled to the compressor, and a compressor controller.
US08859923B2 Input apparatus
An input apparatus including a layered body is provided. The layered body includes an electrostatic capacity type touch sensor, a character and symbol printed film, on which characters or symbols are printed, and a surface light emitting layer configured to illuminate the character and symbol printed film. The character and symbol printed film is arranged on an upper surface side of the surface light emitting layer, the touch sensor is arranged on a lower surface side of the surface light emitting layer, and an input operation surface that is positioned at an uppermost surface is flat.
US08859914B1 Digital scale with removable insert
The present invention is a digital scale having an outside housing that generally is supported from a support surface from a horizontal surface, where the outside housing preferably encloses a microprocessor operating under a control program and is at least connected to a power supply, a sensors/load cell unit, an input/output unit, and a user interface with a display. The sensors/load cell unit is operatively connected with a weighing surface plate, upon which may directly receive to an upper surface an item which will be weighed or which may engage other intervening plates or containers which ultimately support an item to be weighed. The outside housing defines an opening in a bottom, side or top surface which provides access to an adjunct tools container which lies, in a stored position, completely or mainly, within a form factor of the outside housing.
US08859910B2 Circuit board with signal routing layer having consistent impedance
A circuit board includes a dielectric layer and a signal routing layer on the dielectric layer. The signal routing layer includes chip traces, connector traces, and signal traces connected with the chip traces and the connector traces. The dielectric layer includes a signal trace area for arraying the signal traces, a chip trace area for arraying the chip traces, and a connector trace area for arraying the connector traces. The dielectric coefficient of the signal trace area is smaller than the dielectric coefficient of the chip trace area and greater than the dielectric coefficient of the connector trace area.
US08859909B2 Flexible cable for low profile electrical device
A flexible cable with a substrate divided into at least two sections is disclosed. The first section includes a first electrically conductive track and a first attach pad, while the section includes a second and third electrically conductive tracks, as well as a second attach pad. The first section is disposed on the second section to align the attach pads and connect the first electrically conductive track to the third electrically conductive track. The resulting flexible cable can be used with a low profile electrical device.
US08859902B2 Multi-core cable
A multi-core cable in which skew occurs less and attenuation characteristics of all core cables are uniform comprises: a core unit; an insulation tape spirally wrapped around the outer circumference of the core unit; and a metal coated resin tape wrapped over the insulation tape, wherein a plurality of core cables each consisting of two insulated wires arranged in parallel are stranded together to form the core unit, and wherein the metal coated resin tape is wrapped in the same direction as the stranding direction of the core cables.
US08859901B2 Shielded electrical cable
A shielded electrical cable (2202) includes a plurality of conductor sets (2204a, 2204b) that extend along the length of the cable and are spaced apart from each other along the width of the cable. Each conductor set (2204a, 2204b) includes one or more insulated conductors (2206a, 2206b), and first and second shielding films (2208) that are disposed on opposite first and second sides of the cable. The first and second films (2208) include cover portions (2207) and pinched portions (2209). The cable (2202) also includes an EMI absorbine layer (2250). The maximum separation between the first cover portions of the first and second shielding films is D. The minimum separation between the first pinched portions (2209) of the first and second shielding films (2208) is d1. d1/D is less then 0.25. The minimum separation between the first cover portion (2207) of the first and second shielding films (2208) in a region between the first and second insulated conductors (2206a, 2206b) is d2. d2/D is greater than 0.33.
US08859895B2 Method for vertically grounding and leading down from center of composite pole tower and pole tower thereof
A method for vertically grounding and leading down form a center of a composite pole tower includes the following steps: extending a ground down-leading wire from a center of a ground wire cross arm which is made of metal and is positioned on top of the pole tower, wherein the ground down-leading wire is vertically leaded down to the earth form the center of the composite pole tower, wherein when an lower portion of the tower body is a metal pipe, the ground down-leading wire is extended from the center of the composite material and is directly connected to the metal pipe. The method utilizes the advantage of the insulating intensity of the wall of the composite pole tower and enhances the insulating intensity of the transmission line on impact of lightning. The ground down-leading wires are prevented from short-circuiting with the tower body of the composite pole tower, so that advantage of the insulating property of the composite material of the pole towers is realized. Since the ground down-leading wire is penetrated through center of the pole tower, so that the ground down-leading wires are not exposed and are prevented from destroying by external force. And also the method is easy and simple for application.
US08859893B2 Light collection module and solar energy device having the same
A light collection module and a solar energy device are provided. The light collection module includes a light guiding material and a solar energy receiving element. The light guiding material has a first surface and a second surface opposite thereto. The first surface includes a first light guiding structure and a second light guiding structure. The first light guiding structure includes a first light guiding surface and a first auxiliary surface connected to each other and intersected in a first angle. The second light guiding structure includes a second light guiding surface and a second auxiliary surface connected to each other and intersected in a second angle. The inclination directions of the first and the second light guiding surfaces are opposite to each other. The solar energy receiving element is disposed on the first surface or the second surface.
US08859890B2 Solar cell and method of manufacturing the same
A solar cell and a method of manufacturing the same are provided. The solar cell includes: i) a first conductive layer; ii) a plurality of nano structures that are positioned on the first conductive layer and that are extended to cross a surface of the first conductive layer and that are separated from each other; iii) a resin layer that is positioned on the first conductive layer and that is filled at space between the plurality of nano structures; iv) at least one semiconductor layer that is positioned on the resin layer and that covers the plurality of nano structures; and v) a second conductive layer that covers the semiconductor layer and that has a light transmittance lower than that of the first conductive layer.
US08859888B2 Solar cell with nanostructured layer and methods of making and using
A solar cell includes a base and a nanostructured layer formed on the base. The nanostructured layer has a nanostructured surface opposite the base. The nanostructured surface has a quasi-periodic, anisotropic array of elongated ridge elements having a wave-ordered structure pattern, each ridge element having a wavelike cross-section and oriented substantially in a first direction.
US08859885B2 Method for manufacturing photovoltaic cells with multiple junctions and multiple electrodes
A photovoltaic device and method of manufacture of a photovoltaic device including an assembly of at least two photovoltaic cells; and a lamination material inserted between each photovoltaic cell, each photovoltaic cell including: two current output terminals; at least one photovoltaic junction; current collection buses; and connection strips extending from the current collection buses to the current output terminals, all the current output terminals being placed on a single surface of the photovoltaic device.
US08859884B2 Solar photovoltaic module safety shutdown system
A PV system may be used in case of emergencies. Each individual photovoltaic module receives a signal to determine if it is allowed to be operational or must shut down. Modules by default are shut off and safe to handle, absent the signal and in the presence of light.
US08859883B2 Electric power generation method using solar cells and photovoltaic power generation system
A photovoltaic power generation system includes a plurality of power generation panels and a power conditioner. The power generation panels and a radiation source are placed in a solar cell storage room buried typically in the ground. The radiation source includes radioactive waste generated in reprocessing of spent nuclear fuel. Each power generation panel has a phosphor member and a moderator member, which are disposed in that order on solar cells placed on a board. Radiation (for example, a gamma ray) emitted from the radiation source is injected on the power generation panel and is moderated by the moderator member. When the gamma ray with the reduced energy (below 100 keV) is injected on the phosphor member, it emits visible light. When the visible light is injected on the solar cells, electric power is generated.
US08859877B2 Damper drive device for musical instrument, and musical instrument
An elongated lifting rail is displaceable to collectively pivot a plurality of damper levers. An actuator is provided beside or underneath the lifting rail for automatically displacing the lifting rail. The lifting rail is displaced, in response to driving of the actuator, to displace the damper levers so that the dampers are moved away from contact with sounding members. Further, a position sensor is provided for detecting a displaced position of the lifting rail, so that position data detected by the position sensor is used for operating position control and/or operating position recording of the dampers.
US08859876B2 Multi-channel signal processing for multi-channel musical instruments
Multi-channel audio signal processing systems and techniques are provided for electronic instruments having multiple and distinct output channels. Such systems may be used in conjunction with instruments comprising multiple vibrating elements, each with a dedicated signal output. Each received audio signal channel may be directed to a dedicated or shared signal processor for variably changing selected attributes of pitch, timing, timbre, and amplitude in ways that are unique for each signal. Signal processors may be shared using an allocating mixer, allocating switch, or both. An output mixer may be used to mix signal processor output signals into one or more outgoing mixed audio signals. Signal processors, mixers, and switches may be configured by stored program control and controlled in real-time. Real-time pitch variations can be used to change the pitch organization of fixed-pitch vibrating elements within an electronic musical instrument.
US08859866B2 Keyboard instrument
In a predetermined sound generation mode, a drive signal having a frequency characteristic corresponding to an operated key is supplied to an excitation unit provided on a soundboard. In response to a mechanical vibration generated by the excitation unit, the soundboard is vibrated so as to generate an acoustic vibration sound corresponding to the operated key. The excitation unit is supported by a supporting unit such that less or no load of the excitation unit except a vibration member vibrated in response to the drive signal is applied to the soundboard. Thus, only a load of the vibration member which is a very light portion of the excitation unit is applied to the soundboard, thereby vibration characteristics of the soundboard being hardly affected. When a sound damping mode is selected, a stopper is permitted to prevent a hammer from striking a sounding body.
US08859864B1 Maize inbred PH1 KA9
A novel maize variety designated PH1KA9 and seed, plants and plant parts thereof. Methods for producing a maize plant that comprise crossing maize variety PH1KA9 with another maize plant. Methods for producing a maize plant containing in its genetic material one or more traits introgressed into PH1KA9 through backcross conversion and/or transformation, and to the maize seed, plant and plant part produced thereby. Hybrid maize seed, plant or plant part produced by crossing the variety PH1KA9 or a locus conversion of PH1KA9 with another maize variety.
US08859861B2 Melon variety NUN 02602 ME
The invention relates to the field of Cucumis melo, in particular to a new variety of Cucumis melo reticulatus, NUN 02602 ME, plants, seeds and melon fruits.
US08859860B2 Watermelon variety WAS-45-2158S
The invention provides seed and plants of the watermelon line designated WAS-45-2158S. The invention thus relates to the plants, seeds and tissue cultures of watermelon line WAS-45-2158S, and to methods for producing a watermelon plant produced by crossing a plant of watermelon line WAS-45-2158S with itself or with another watermelon plant, such as a plant of another line. The invention further relates to seeds and plants produced by such crossing. The invention further relates to parts of a plant of watermelon line WAS-45-2158S, including the fruits and gametes of such plants.
US08859859B2 Downy mildew resistant cucumber plants
The present invention relates to cucumber lines having increased resistance to Downy Mildew. The present invention also relates to parts of cucumber plants from lines having increased Downy Mildew resistance, including seeds capable of growing cucumber plants with increased Downy Mildew resistance. Further provided are methods of producing such plants by genetic marker assisted selection.
US08859857B2 Plants and seeds of spring canola variety SCV259778
In an embodiment, the invention relates to the seeds, plants, and plant parts of canola line SCV259778 and to methods for producing a canola plant produced by crossing canola line SCV259778 with itself or with another canola line. The invention also relates to methods for producing a canola plant containing in its genetic material one or more transgenes and to the transgenic canola plants and plant parts produced by those methods. This invention also relates to canola lines or breeding lines and plant parts derived from canola line SCV259778, to methods for producing other canola lines, lines or plant parts derived from canola line SCV259778 and to the canola plants, varieties, and their parts derived from use of those methods. The invention further relates to hybrid canola seeds, plants and plant parts produced by crossing the line SCV259778 with another canola line.
US08859854B2 Method for modifying plant morphology, biochemistry and physiology
The present invention provides methods and compositions for increasing seed size and/or weight, embryo size and/or weight, and cotyledon size and/or weight. The methods comprise expression of a cytokinin oxidase or expression of another protein that reduces the level of active cytokinins in plants or plant parts. Methods and compositions for increasing seed yield are also provided. The invention also relates to isolated plant cytokinin oxidase proteins, nucleic acid sequences encoding cytokinin oxidase proteins as well as to vectors, host cells, transgenic cells and plants comprising such sequences.
US08859853B2 Capsules containing vital cells or tissues
Artificial seeds formed of a seamless soft capsule are provided herein. The artificial seed contains a meristematic plant cell or tissue. The artificial seed has a structure of three or more layers containing an innermost layer, an inner layer covering the innermost layer, and an outer layer covering the inner layer. The innermost layer can contain an aqueous liquid, the inner layer can be formed by an inner membrane containing hardened oil, and the outer layer can be formed of a biodegradable outer membrane.
US08859852B2 Transformation of a plant to promote root and/or leaf growth
The present invention is directed to identify genes involved in the growth of a plant and provide a transformed plant the growth of which is promoted utilizing the genes.
US08859851B2 Cold-tolerant plants expressing MYBS3 and DREB1A proteins
Disclosed are chill- or cold-tolerant plants and methods of making the plants. Also disclosed are methods for identifying a plant that is tolerant to chill.
US08859843B2 Absorbent article with containment barrier
An absorbent article comprising a chassis comprising a topsheet, a backsheet, an absorbent core disposed between the topsheet and the backsheet, and a pair of longitudinal barrier cuffs attached to the chassis. Each longitudinal cuff is formed of a web of material having first and second opposing surfaces and comprising a nonwoven component layer comprising fibers having a number-average diameter of less than about 1 micron, a mass-average diameter of less than about 1.5 microns, and a ratio of the mass-average diameter to the number-average diameter less than about 2. The absorbent article further comprises a hydrophobic coating disposed on at least one surface of the web of material.
US08859837B2 Process for oxidative dehydrogenation of paraffinic lower hydrocarbons
The present invention relates to a process for producing lower olefinic hydrocarbons by oxidative dehydrogenation of paraffinic lower hydrocarbons. More particularly the present invention provides a process for converting a feedstream comprising a paraffinic lower hydrocarbon and carbon dioxide to a product stream comprising an olefinic lower hydrocarbon and synthesis gas in the presence of the catalyst composition La—Mn/inert support, wherein said catalyst composition comprises 1-10 mass % lanthanum and 1-10 mass % manganese and optionally 0.3-3 mass % alkali metal.
US08859831B2 Removal of hydrogen sulfide as ammonium sulfate from hydropyrolysis product vapors
A system and method for processing biomass into hydrocarbon fuels that includes processing a biomass in a hydropyrolysis reactor resulting in hydrocarbon fuels and a process vapor stream and cooling the process vapor stream to a condensation temperature resulting in an aqueous stream. The aqueous stream is sent to a catalytic reactor where it is oxidized to obtain a product stream containing ammonia and ammonium sulfate. A resulting cooled product vapor stream includes non-condensable process vapors comprising H2, CH4, CO, CO2, ammonia and hydrogen sulfide.
US08859830B2 Methods and assemblies for liquid-phase reactions
Methods and assemblies for improving the reaction kinetics of, conserving reactants utilized in, and/or producing a more pure reaction product of, liquid-phase reactions that involve volatile reactants and products are provided. The methods and assemblies herein provide for a feed of reaction liquid to two or more absorption zones, wherein the temperature and/or feed rate of the liquid is independently adjusted prior to introduction into at least one of the two or more absorption zones. More particularly, the temperature and feed rate of the liquid as delivered to each absorption zone can be adjusted independently to optimize the absorption of at least a portion of any gaseous reactants and byproducts from the gaseous product stream and/or to optimize reaction zone conditions. Reaction kinetics may thus be improved, or substantially maintained.
US08859827B2 Esterifying acetic acid to produce ester feed for hydrogenolysis
Disclosed herein are processes for alcohol production by reducing an esterification product, such as ethyl acetate. The processes comprise esterifying an excess molar ratio of acetic acid with an alcohol, such as ethanol, to produce the esterification product. The esterification product is reduced with hydrogen in the presence of a catalyst to obtain a crude reaction mixture comprising the alcohol, in particular ethanol, which may be separated from the crude reaction mixture.
US08859825B2 Process for isolating crystallized 2,2,4,4-tetramethyl-1,3-cyclobutanediol (TMCD) particles utilizing pressure filtration
A method for isolating 2,2,4,4-tetramethyl-1,3-cyclobutanediol (TMCD) solids from an isolated feed slurry formed in a TMCD process comprising TMCD, a liquid phase, and impurities by (a) treating the isolated feed slurry in a product isolation zone to produce an isolated TMCD product wet cake, a mother liquor, and impurities; wherein the product isolation zone can comprise at least one rotary pressure drum filter.
US08859823B2 OXO process and method for producing synthesis gas from waste oil
An improved OXO process with converted waste oil recycle includes: (a) hydroformylating an olefin with synthesis gas in a reactor to produce an OXO product as well as by-product waste oil, the by-product waste oil having a lower or higher boiling temperature than said OXO product; (b) separating OXO product from the by-product waste oil; (c) converting separated waste oil to synthesis gas; and (d) recycling the synthesis gas produced in step (c) to the reactor of step (a).
US08859822B2 Synthesis of substituted salicylaldehyde derivatives
Among other things, the present invention encompasses methods of synthesizing salicylaldehyde derivatives comprising the steps of: a) providing salicylaldehyde or a derivative thereof, b) forming an anhydro dimer of the provided salicylaldehyde compound, c) performing one or more chemical transformations on the anhydro dimer and d) hydrolyzing the anhydro dimer to provide a salicylaldehyde derivative different from that provided in step (a).
US08859818B2 Electrophotographic photoreceptor
An object of the present invention is to provide a charge transport material and an electrophotographic photoreceptor using the charge transport material, the charge transport material sufficiently satisfying characteristics conventionally desired for a charge transport material for an electrophotographic photoreceptor, specifically, the charge transport material having a good solubility in a binder polymer, allowing formation of a stable and high-concentration organic thin film therefrom, and having a high carrier mobility. To achieve the object, the present invention provides a tris(4-styrylphenyl)amine derivative represented by the following general formula (1): wherein R1 represents a methyl group or methoxy group, and R2 represents a hydrogen atom, methyl group, or methoxy group, provided that a case where R1 and R2 are a methyl group and R2 is at the meta-position is excluded; wherein 50% or more of geometrical isomers have three double bonds which are all trans.
US08859816B2 Method for producing polyamide
A process for the manufacture of polyamide is described. Also described, is a process comprising a stage of initial polymerization under pressure starting from monomers and a stage of finishing in the liquid phase at atmospheric pressure. The finishing stage can employ an injection of inert gas along a direction essentially parallel to that of the flow of the liquid reaction stream.
US08859815B2 Sulphonylated diphenylethylenediamines, method for their preparation and use in transfer hydrogenation catalysis
A diamine of formula (I) is described in which A is hydrogen or a saturated or unsaturated C1-C20 alkyl group or an aryl group; B is a substituted or unsubstituted C1-C20 alkyl, cycloalkyl, alkaryl, alkaryl or aryl group or an alkylamino group and at least one of X1, X2, Y1, Y2 or Z is a C1-C10 alkyl, cycloalkyl, alkaryl, aralkyl or alkoxy substituting group. The chiral diamine may be used to prepare catalysts suitable for use in transfer hydrogenation reactions.
US08859814B2 Alpha-substituted N-sulfonyl gylcine amides antagonists of CCR10, compositions containing the same and methods for using them
Disclosed is a compound of formula (I). Wherein R1, R2Ar and Cy are as defined herein, or a pharmaceutically acceptable salt thereof. Also disclosed are pharmaceutical compositions of the compound of formula (I), methods of making the compounds of formula I, and methods of using the compounds of formula (I) to treat a disorder associated with activation of CCR10.
US08859812B2 Compound reagents and method for synthesizing enantiomerically enriched amino acids
Described herein are compounds of formula (I), related compositions, and their use, for example in the formation of α-amino acids or a precursor thereof such as an α-aminonitrile.
US08859809B2 Device and process for crystallizing (meth)acrylic acid
A crystallization device and a crystallization process are provided for obtaining (meth)acrylic acid with higher purity without causing leakage of a crude solution by preventing complete clogging in a crystallization tube from occurring. The device for crystallizing (meth)acrylic acid includes a crude (meth)acrylic acid solution supply part, a crystallization tube, a heat medium supply tube, a heat medium discharge tube, a storage part of a crude (meth)acrylic acid solution passed through the crystallization tube, a tube for circulating and supplying the crude (meth)acrylic acid solution to the supply part from the storage part, and a pump for circulating and supplying the crude (meth)acrylic acid solution to the supply part from the storage part, and also includes a pressure meter in the circulate-supply tube. The device is used for carrying out dynamic crystallization in a batch manner by circulating the crude (meth)acrylic acid solution to flow the crude solution downward along the inner wall of the crystallization tube in a coating film-like state.
US08859800B2 Compounds containing alkyl-alkoxy-cyano-borate anions
The invention relates to new compounds containing alkyl-alkoxy-cyano-borate anions, their preparation and their use, in particular as part of electrolyte formulations for electrochemical or optoelectronic devices.
US08859796B1 Synthetic and purification methods for phosphaplatin compounds and uses thereof
This application discloses novel methods and processes for preparation and purification of phosphaplatin compounds. The improvements of the synthetic methods and purification processes include, but are not limited to, efficient and reproducible large-scale preparation of these useful pharmaceutical agents in high quality and good yield.
US08859795B2 Process for producing ester of carboxylic acid from cellulosic biomass
The invention discloses a technology for producing ester of carboxylic acid using cellulosic biomass as starting material. This technology comprises the following key steps: converting all of the organic polymers, including such high molecular-weight polymers as carbohydrate components and lignin, in cellulosic biomass into water soluble, small molecular organics completely in relatively short time under relatively mild conditions; separating the resultant water soluble compounds containing aromatic rings by adjusting the acidity/basicity of the reaction solution or by using adsorption resin; and converting the water soluble compounds containing aromatic rings into ester of carboxylic acid by hydrogenation and esterification in a corresponding alcohol solution.
US08859793B2 Process for extracting oil from plants and animal matter
A process for extracting fats and oils from plant and animal matter using a normally gaseous solvent in its liquid state. Use is made of gravity flow and pressure differential from one vessel to another to transfer solvent from an upper vessel to a lower vessel. The vessels comprise an outer jacket to allow cooling and heating fluid to flow there-through to achieve better control of the pressure within each vessel.
US08859792B2 Olefin epoxidation process
A process for the production of an olefin oxide, which process comprises reacting a feed comprising an olefin and oxygen in a reactor tube in the presence of a silver-containing catalyst, wherein the presence of water in the catalyst bed is controlled such that the ratio of the partial pressure of water (PPH2O) divided by the vapor pressure of water (VPH2O) is less than 0.006, preferably less than 0.004.
US08859790B2 Process for the manufacture of a 1,2-epoxide and a device for carrying out said process
Apparatus and processes are provided for forming epoxide compounds. In one embodiment, a process for the manufacture of an epoxide is provided including adding an oxidant, a water-soluble manganese complex and a terminal olefin to form a multiphasic reaction mixture, reacting the terminal olefin with the oxidant in the multiphasic reaction mixture having at least one organic phase in the presence of the water-soluble manganese complex, separating the reaction mixture into the at least one organic phase and an aqueous phase, and reusing at least part of the aqueous phase. The invention is also related to a device for performing the above process.
US08859787B2 Glycol compound having dioxane structure and method for producing the same
Disclosed is a glycol compound which is useful as a raw material and an intermediate for synthetic resins, additives for synthetic resins, medicines, cosmetics, food additives, surfactants and the like, further disclosed is a method for producing the compound.The glycol compound is represented by the following Formula (1): wherein R represents an alkyl group having 1 to 12 carbon atoms, a substituted or unsubstituted aryl group having 6 to 10 carbon atoms or a halogen atom; n represents an integer of 1 to 4; and when n represents an integer of 2 to 4, plural R may be the same or different from each other.
US08859781B2 No-releasing nonoate(nitrogen-bound)sulfonamide-linked-coxib anti-cancer agents
The present invention provides NO-releasing NONOate(nitrogen bound)sulfonamide-linked-coxib anti-cancer agents, having the structure of Formula (I): wherein R1, X, L, R2, R3, R4, and Z are as defined in the detailed description; pharmaceutical compositions comprising at least one compound of Formula (I); and methods useful for healing wounds, preventing and treating cancer, or treating actinic keratosis, cystic fibrosis or acne, using a compound of Formula (I).
US08859779B2 Catalyst complex with carbene ligand
Catalytic complexes including a metal atom having anionic ligands, at least one nucleophilic carbene ligand, and an alkylidene, vinylidene, or allenylidene ligand. The complexes are highly stable to air, moisture and thermal degradation. The complexes are designed to efficiently carry out a variety of olefin metathesis reactions.
US08859777B2 4-fluoro-4-arylpiperdin-1-yl derivatives as mu opioid function moderators
4-Fluoro-4-phenylpiperidin-1-yl μ antagonists of general structure as well as pharmaceutical compositions comprising compounds of formula I, are disclosed. These compounds and compositions are useful as treatments of conditions or diseases associated with binding opioid receptors including pain, obesity, hyperalgesia, inflammation, osteoarthritis, drug addiction, and cancer. These compounds and compositions are also useful as treatments for tardive dyskinesia.
US08859776B2 Substituted piperidines that increase p53 activity and the uses thereof
The present invention provides a compound of Formula 1 as described herein or a pharmaceutically acceptable salt, solvate or ester thereof. The compounds are useful as inhibitors of the HDM2 protein. Also disclosed are pharmaceutical compositions comprising the above compounds and methods of treating cancer using the same.
US08859771B2 Organic electroluminescent compound containing iridium, preparation method thereof and organic electroluminescent device
An organic electroluminescent compound containing Iridium, preparation method thereof and an organic electroluminescent device are disclosed. The compound is represented by the structure (2), wherein, R is C1˜C4 alkyl. The structure of the compound contains bipyridine ligand, also carries alkoxy group and fluorine atom, which improves its carrier injection and transfer ability, and increases its internal quantum efficiency and electroluminescent efficiency. Furthermore, the compound uses strong field ligand 2-pyridine carboxylic acid as assistant ligand, which causes an effective blue shift of its emission spectrum and increases light-emitting efficiency of blue light phosphorescence greatly.
US08859770B2 Process for preparing [4,6-bis-dimethylamino-2-[4-(4-trifluoromethylbenzoylamino)benzyl]pyrimidin-5-yl]acetic acid
The present invention relates to a process for preparing a compound of formula (I).
US08859769B2 Processes for preparing ticagrelor intermediate, 4,6-dichloro-5-nitro-2-(propylthio)pyrimidine
Provided herein are improved, commercially viable and industrially advantageous processes for the preparation of a substantially pure ticagrelor intermediate, 4,6-dichloro-5-nitro-2-(propylthio)pyrimidine, Formula (II). The intermediate is useful for preparing ticagrelor, or a pharmaceutically acceptable salt thereof in high yield and purity.
US08859768B2 Heteroaryls and uses thereof
This invention provides compounds of formula IA or IB: wherein HY, R1, R2, and G1, are as described in the specification. The compounds are inhibitors of VPS34 and/or PI3K and are thus useful for treating proliferative, inflammatory, or cardiovascular disorders.
US08859767B2 Method for preparing 1-(4-(4-(3,4-dichloro-2-fluorophenylamino)-7-methoxyquinazolin-6-yloxy)piperidin-1-yl)-prop-2-en-1-one hydrochloride and intermediates used therein
The present invention relates to an improved method for preparing 1-(4-(4-(3,4-dichloro-2-fluorophenylamino)-7-methoxyquinazolin-6-yloxy)piperidin-1-yl)-prop-2-en-1-one hydrochloride, which selectively and effectively inhibits the growth of cancer cells induced by over-expression of an epidermal growth factor receptor (EGFR) and prevents the development of drug resistance caused by mutation of a tyrosine kinase, and intermediates used therein.
US08859763B1 Process for the synthesis of 3,4-dimethoxybicyclo[4.2.0]OCTA-1,3,5-triene-7-carbonitrile, and application in the synthesis of ivabradine and addition salts thereof with a pharmaceutically acceptable acid
Process for the synthesis of the compound of formula (I): Application in the synthesis of ivabradine, addition salts thereof with a pharmaceutically acceptable acid and hydrates thereof.
US08859761B2 Refining process of Cefamandole sodium
It discloses a novel process for refining cefamandole nafate, comprising: 1) adsorbing cefamandole nafate with strongly acidic ion exchange resin, followed by eluting the resin and collecting the eluate, to provide a primary purified cefamandole acid after concentration under reduced pressure; 2) neutralizing the primary purified cefamandole acid with an aqueous solution of sodium hydroxide or an aqueous solution of basic salt of sodium, followed by adjusting the pH value and filtrating out the insoluble substances with heating, thereby providing a secondary purified aqueous solution of cefamandole nafate; and 3) adding ethanol in a volume ratio between ethanol and water of 4:6 into the aqueous solution, to allow recrystallization under controlling the temperature, to provide a tertiary purified cefamandole nafate. The refined cefamandole nafate product has a purity of no less than 99.5%, mostly no less than 99.6%, with significantly low content of heavy metals.
US08859760B2 Compositions for killing or preventing the growth of microbes
Described herein are methods and compositions for killing or preventing the growth of microbes. It has been discovered that a class of porphyrins can kill or prevent the growth of microbes. The porphyrins can be used in a number of different applications where microbes grow.
US08859755B2 Method for preparing ribonucleoside phosphorothioate
A method for preparing a phosphorothioate RNA based on the oxazaphospholidine method, wherein cyanoethoxymethyl group is used instead of tert-butyldimethylsilyl group as a protective group of 2′-hydroxyl group of RNA.
US08859751B2 Oligonucleotide compounds comprising non-nucleotide overhangs
The invention relates to siRNA compounds comprising one non-nucleotide moiety covalently attached to at least one of the sense or antisense strands to down-regulate the expression of human genes. The invention also relates to pharmaceutical compositions comprising such compounds and a pharmaceutically acceptable carrier and to methods of treating and/or preventing the incidence or severity of various diseases or conditions associated with the target genes and/or symptoms associated with such diseases or conditions.
US08859750B2 RNAi modulation of RSV and therapeutic uses thereof
The present invention is based on the in vivo demonstration that RSV can be inhibited through intranasal administration of iRNA agents as well as by parenteral administration of such agents. Further, it is shown that effective viral reduction can be achieved with more than one virus being treated concurrently. Based on these findings, the present invention provides general and specific compositions and methods that are useful in reducing RSV mRNA levels, RSV protein levels and viral titers in a subject, e.g., a mammal, such as a human. These findings can be applied to other respiratory viruses.
US08859749B2 Modified short interfering RNA
The present invention refers to a double-stranded siRNA molecule comprising a sense Strand and an antisense Strand which is essentially complementary to the sense Strand, each of the sense and the antisense Strands comprising at least 17 nucleotides (nt), the siRNA further comprising at least one overhang at the 5′ and/or 3′ end, wherein the overhang residue or overhang residues are chemically modified and selected independently from each other from the group consisting of: (a) 2′-deoxy modified nucleotides; (b) 2′-methoxy modified nucleotides; (c) two nucleosides linked by a 3′ to 5′ or 2′ to 5′ formacetal linkage; (d) nucleotides modified at the 2′-position by a —O—CH2—O—(CH2)2—OH group; and (e) nucleotides comprising in the 3′-position a —CH2—O—(CH2)7—CH3 group.
US08859748B2 Nucleic acid amplification primers for PCR-based clonality studies
The invention relates to PCR-based clonality studies for among others early diagnosis of lymphoproliferative disorders. Provided is a set of nucleic acid amplification primers comprising a forward primer, or a variant thereof, and a reverse primer, or a variant thereof, capable of amplifying a rearrangement selected from the group consisting of a VH-JH IGH rearrangement, a DH-JH IGH rearrangement, a VK-JK IGK rearrangement, a VK/intron-Kde IGK rearrangement, a Vλ-Jλ IGL rearrangement, a Vβ-Jβ TCRB rearrangement, a Dβ-Jβ TCRB rearrangement, a Vγ-Jγ TCRG rearrangement, a Vδ-Jδ TCRD rearrangement, a Dδ-Dδ TCRD rearrangement, a Dδ-Jδ TCRD rearrangement, a Vδ-Dδ TCRD rearrangement, or a translocation selected from t(11;14)(BCL1-IGH) and t(14;18)(BCL2-IGH). The primers can be used in PCR-based clonality studies for early diagnosis of lymphoproliferative disorders and detection of minimal residual disease (MRD). Also provided is a kit comprising at least one set of primers of the invention.
US08859745B2 Promoters exhibiting endothelial cell specificity and methods of using same
An isolated polynucleotide functional as a promoter in eukaryotic cells is disclosed. The isolated polynucleotide includes an endothelial specific enhancer element as detailed herein. Further disclosed is a method of expressing a nucleic acid sequence of interest in endothelial cells.
US08859743B2 Controlling microbial contamination in alcoholic fermentation process
The control of the microbial contamination during the sugar fermentation in the processes for obtaining alcohol is a very important action to increase the productivity of the alcoholic fermentation processes. The Saccharomyces cerevisiae yeast cells engage a very tough nutritional competition for the sugarcane juice with the bacteria (Lactobacillus sp and Acetobacter) and the wild yeasts. The proposed composition uses an antimicrobial agent of the guanidine family, such as for example, poly(hexamethyl biguanide), an antibiotic agent, and also a surfactant agent, to prevent the undesired microbial growth. The present invention further refers to the process for controlling the microbial contamination through the use of said agents.
US08859742B2 Diagnostic assays for chordopoxviruses
This disclosure relates to compositions and methods of their use in detection and identification of a chordopoxvirus in a sample, such as diagnosis of an infection in a subject. The compositions and methods allow for detection and identification of all non-avian low-GC content chordopoxviruses, identification of most known high-GC content chordopoxvirus, and species-specific detection of Canarypox virus, Fowlpox virus, and Sealpox virus.
US08859741B2 Antigen binding proteins to proprotein convertase subtilisin kexin type 9 (PCSK9)
Antigen binding proteins that interact with Proprotein Convertase Subtilisin Kexin Type 9 (PCSK9) are described. Methods of treating hypercholesterolemia and other disorders by administering a pharmaceutically effective amount of an antigen binding protein to PCSK9 are described. Methods of detecting the amount of PCSK9 in a sample using an antigen binding protein to PCSK9 are described.
US08859739B2 Anti-huTNFR1 antibody and methods of use thereof for treatment
The disclosure to an anti-huTNFR1 antibody of the IgG1 type, which has a modified Fc region deficient in mediating effector function, a pharmaceutical preparation comprising such antibody, and an anti-huTNFR1 antibody of the IgG1 type for use as a TNF antagonist without forming an agonistic TNFR1 signalling complex, as an alternative to treatment with an anti-TNF therapeutic.
US08859738B2 Cytotoxic immunoglobulin
The invention relates to a cytotoxic modular antibody with a molecular weight of up to 6 OkD, specifically binding to a cell surface target with a binding affinity of Kd<10−8 M, a method of producing such antibody and its use as a therapeutic.
US08859733B2 Compositions and methods for promoting wound healing and tissue regeneration
Provided herein are compositions and methods for use in promoting wound healing and tissue regeneration following tissue injury in a subject.
US08859731B2 Selective modification of proteins
A method of selectively introducing a substituent into a protein proximal to a binding site on the protein for a homing peptide, comprising: (a) contacting the protein with a compound comprising a homing peptide having the ability to bind to the binding site of the protein; and (b) allowing a moiety on the protein proximal to the binding site to react with the compound comprising the homing peptide, thereby to transfer the substituent G onto the protein.
US08859728B2 Peptides that target dorsal root ganglion neurons
The present invention concerns methods and compositions that employ peptides that target dorsal root ganglion (DRG) neurons. In particular, the peptides are used to target therapeutic agents, such as proteins, liposomes, or viral particles comprising therapeutic polynucleotides, to one or more peripheral neuropathies or neuropathic pain, for example. In particular cases, the peripheral neuropathies or neuropathic pain is caused directly or indirectly by DRG neuronopathy.
US08859726B2 Affinity chromatography matrix
The present invention relates to a method of separating one or more immunoglobulin containing proteins from a liquid. The method includes first contacting the liquid with a separation matrix comprising ligands immobilised to a support; allowing the immunoglobulin containing proteins to adsorb to the matrix by interaction with the ligands; followed by an optional step of washing the adsorbed immunoglobulin containing proteins; and recovering said immunoglobulin containing proteins by contacting the matrix with an eluent which releases the proteins. The method improves upon previous separation methods in that each of the ligands comprises one or more of a protein A domain (E, D, A, B, C), or protein Z, or a functional variant thereof, with at least one of the monomers having a substitution of the C-terminal most proline residue after the third alpha-helix.
US08859713B2 Process for making polyethylene terephthalate
The invention relates to a process for making polyethylene terephthalate (PET) from ethylene glycol (EG), purified terephthalic acid (PTA) and optionally up to 30 mol % comonomer, using a catalyst system essentially consisting of antimony—(Sb), zinc—(Zn) and phosphorous—(P) compounds, comprising the steps of a) esterifying EG and PTA to form diethyleneglycol terephthalate and oligomers (DGT), and b) melt-phase polycondensing DGT to form polyester and EG1 wherein the Sb- and P-compounds are added in step a) and the Zn-compound is added after step a). With this process PET can be obtained that shows favorable color and optical clarity, also if recycling of EG is applied in the process, and a relatively low rate of acetaldehyde regeneration during melt-processing.
US08859712B2 Synthesis of and curing additives for phthalonitriles
A method of: providing a solution of a dichloroaromatic compound having an electron-withdrawing group bound to each aromatic ring containing one of the chloride groups; a dihydroxyaromatic compound; an organic transition metal complex or a transition metal salt; a base; and a solvent; and heating the solution to a temperature at which the dichloroaromatic compound and the dihydroxyaromatic compound react to form a dimetallic salt of an aromatic ether oligomer. The molar ratio of the dihydroxyaromatic compound to the dichloroaromatic compound is greater than 2:1. Water formed during the heating is concurrently distilled from the solution.
US08859708B2 Silicone resins, silicone composition, and coated substrates
Silicone resins containing disilyloxane units, a silicone composition containing a silicone resin, and a coated substrate comprising a cured product or an oxidized product of a silicone resin.
US08859704B2 High pressure low density polyethylene resins with improved optical properties produced through use of highly active chain transfer agents
Disclosed is an ethylene-based polymer with a density from about 0.90 to about 0.94 in grams per cubic centimeter, with a molecular weight distribution (Mw/Mn) from about 2 to about 30, a melt index (I2) from about 0.1 to about 50 grams per 10 minutes, and further comprising sulfur from about 5 to about 4000 parts per million. The amount of sulfur is also determined based upon the total weight of the ethylene-based polymer. Also disclosed is process for making an ethylene-based polymer which includes the steps of splitting a process fluid for delivery into a tubular reactor; feeding an upstream process feed stream into a first reaction zone and at least one downstream process feed stream into at least one other reaction zone, where the process fluid has an average velocity of at least 10 meters per second; and initiating a free-radical polymerization reaction.
US08859703B2 Bimodal pipe resin and products made therefrom
Disclosed is a bimodal Ziegler-Natta catalyzed polyethylene, having a density of from 0.930 g/cc to 0.960 g/cc, and a molecular weight distribution of from 10 to 25, wherein an article formed therefrom has a PENT of at least 1500. Also disclosed is a method of preparing a tubular article including obtaining a bimodal polyethylene having a density of from 0.930 g/cc to 0.960 g/cc and a molecular weight distribution of from 10 to 25, and processing the polyethylene under conditions where a specific energy input (SEI) is less than 300 kW·h/ton, and wherein the article has a PENT of at least 1500. Further disclosed is a method for controlling the degradation of polyethylene including polymerizing ethylene monomer, recovering polyethylene, extruding the polyethylene, and controlling the degradation of polyethylene by measuring the SEI to the extruder and adjusting throughput and/or gear suction pressure keep SEI less than 300 kW·h/ton, and forming an article.
US08859700B2 Method for producing a water-absorbent resin
A method for producing a water-absorbent resin having a further reduced odor as compared with a water-absorbent resin obtained by a conventional method as well as a water-absorbent resin produced by the same method, by maintaining the addition rate V from the pouring nozzle for the aqueous solution of the water-soluble ethylenically unsaturated monomer in a polymerization reaction tank not more than 0.30 [min−1], in the first stage polymerization step which is within the step of the conventional method upon performing multi-stages such as two or more stages of reversed-phase suspension polymerizations in a method for producing a water-absorbent resin, and thereby by being able to reduce the amount of the petroleum hydrocarbon dispersion medium remaining in the above water-absorbent resin.
US08859699B2 Non-specific adsorption inhibitor
A non-specific adsorption inhibitor includes a water-soluble polymer obtained by polymerizing a monomer unit that includes a monomer (A) that forms a polymer that has a lower critical solution temperature (LCST) of 80° C. or less in an aqueous solution under normal pressure when subjected to homopolymerization, and a monomer (B) that forms a polymer that does not have the LCST in an aqueous solution under normal pressure when subjected to homopolymerization.
US08859698B2 Sulfur-containing macromolecules and methods for their preparation
A sulfur-containing macromolecule and a method of preparing the sulfur-containing macromolecule comprising a polymerization step are provided, where the sulfur-containing macromolecule contains internal units of formula (I) and the polymerization step is formula (II) wherein n is greater than 1, said precursor comprises alkyne having one or more acetylene groups and thiol having one or more thiol groups; and R is remainder of said thiol excluding said thiol groups, R′ is remainder of said alkyne excluding said acetylene groups, and R and R′ are selected from organic or organometallic groups.
US08859696B2 Oligomerisation of olefinic compounds with reduced polymer formation
A process for producing an oligomeric product by oligomerization of at least one olefinic compound, the process including a) providing an activated oligomerization catalyst, by combining, in any order, i) a source of chromium, ii) a ligating compound, iii) a catalyst activator or combination of catalyst activators, b) providing a zinc compound, and c) contacting the at least one olefinic compound with a composition containing the activated oligomerization catalyst and the zinc compound, the zinc compound being present in a sufficient quantity such that the ratio of the molar amount of zinc in the zinc compound to the molar amount of chromium in the source of chromium is between 1 and 10,000. The invention also provides a process of activating an oligomerization catalyst to be used to produce an oligomeric product from at least one olefinic compound.
US08859695B2 Activator for epoxy resin compositions
A hem-curing epoxy resin composition, that includes an epoxy resin A having more than one epoxy group per molecule on average; a curing agent B for epoxy resins, which is activated at a temperature in a range of 100° C. to 220° C.; and an activator C for epoxy resin compositions, wherein activator C is a compound of formula (I), or is a reaction product between a compound of formula (Ia) and an isocyanate or an epoxide.
US08859692B2 Process for reacting thermoplastic polyurethanes with compounds having isocyanate groups
Process for reacting thermoplastic polyurethanes with compounds having isocyanate groups, wherein the reaction is carried out in the presence of a prepolymer which is the reaction product of (a) isocyanates with (b) compounds which are reactive toward isocyanates and have a molecular weight in the range from 500 g/mol to 10 000 g/mol, preferably from 2000 g/mol to 8000 g/mol, and the prepolymer has a glass transition temperature Tg measured by means of DSC in accordance with DIN EN ISO 11357-1 below −35° C.
US08859685B2 Polyacrylic acid (salt)-type water absorbent resin and method for producing of same
A process for producing a water absorbent resin is provided with which it is possible to efficiently and inexpensively obtain a surface-crosslinked water-absorbing resin having excellent material properties, while ensuring high productivity. In continuous production scaled up to a large scale (in particular, 1 t/hr or more), the physical properties are improved and stabilized (for example, a reduction in standard deviation of the physical properties) by a surface crosslinking treatment to further improve absorption against pressure (AAP) and saline flow conductivity (SFC). The process for producing a polyacrylic acid (salt)-type water absorbent resin includes a surface treatment step in which after addition of a surface-crosslinking agent, a crosslinking reaction is conducted in a transverse type continuous stirring apparatus having stirring means including a feeding inlet and a discharging outlet of a water absorbent resin and one or more rotary shafts having with a plurality of stirring discs, and heating means, at a stirring-power index of the device of 3-15 W·hr/kg. (Stirring-power index)=((power consumption of apparatus at the time surface treatment)−(power consumption at the time of idling))×average retention time)/(treatment amount per unit time×average retention time).
US08859683B2 Optical resin composition, optical resin material using the same, optical filter for image display device, and image display device
An optical resin composition that is transparent, has suitable adhesion and necessary impact absorption for protection of an image display device etc., not affecting constituent materials of a image display panel, and being excellent in reliability, can be used to provide an optical resin material using the same. The optical resin composition contains (A) a first acrylate derivative that is a compound having one polymerizable unsaturated bond in its molecule, (B) a second acrylate derivative that is a compound having two or more polymerizable unsaturated bonds in its molecule, and (C) an acrylate derivative polymer, and an optical resin material produced by curing reaction of the optical resin composition.
US08859682B2 Packaging element
The invention relates to a tape-like packaging element made from a polyester-based plastic tape, the plastic tape comprising at least one splicing inhibitor, wherein the splicing inhibitor is a thermoplastic, styrene-based polymer.
US08859681B2 Polyester blends exhibiting low temperature toughness
Polymer blends suitable for packaging are disclosed that include one or more impact modifiers; and one or more polyethylene terephthalate homopolymers or copolymers obtained by a melt phase polymerization using a catalyst system comprising aluminum atoms in an amount, for example, from about 3 ppm to about 60 ppm and one or more alkaline earth metal atoms, alkali metal atoms, or alkali compound residues in an amount, for example, from about 1 ppm to about 25 ppm, in each case based on the weight of the one or more polyethylene terephthalate homopolymers or copolymers The polymer blends disclosed exhibit improved low temperature toughness compared with blends made using polymers prepared with conventional catalyst systems.
US08859679B2 Aqueous solutions of optical brighteners
The instant invention relates to storage stable aqueous solutions of stilbene optical brighteners with polyvinyl alcohols which can be directly used by the papermaker in that they may be diluted with water and/or be metered directly into a coating composition, to provide coated papers of a particularly high whiteness.
US08859671B2 Photodegradable films with good tensile and dart properties
Film structures made from a polymeric blend comprising an ethylene/carbon monoxide (ECO) copolymer and an olefinic, particularly an ethylenic, polymer, e.g., LDPE, exhibit not only photodegradation, but also desirable tensile and dart properties. In one embodiment the film structure is a monolayer in which ECO copolymer comprises at least 40 weight percent with the remainder of the structure comprising at least one of LDPE, LLDPE and HDPE.
US08859663B2 Calcium carbonate having a surface charge, the preparing process thereof and filler for producing a paper using the same
The present invention relates to a calcium carbonate having a surface charge, the preparing process thereof and filler for producing a paper using the same. The present invention provides the process of preparing a calcium carbonate having a surface charge, characterized in that it comprises the following steps of: preparing a solution mixture of one or more monomer selected from the group consisting of calcium hydroxide, acrylic acid, acrylamide, or [2-(acryloyloxy)ethyl]-trimethylammonium chloride; removing dissolved gases such as oxygen and carbon dioxide in the said solution by injecting nitrogen (N2) gas; adjusting pH of the said solution; and inducing a reaction by adding polymerization initiator of a high molecule while injecting carbon dioxide to the said mixture.
US08859660B2 Rubber composition for studless tire and studless tire using the same
The present invention has its object to provide a rubber composition for a studless tire that contributes to both good braking force and high handling stability on ice or snow, and a high performance studless tire using the rubber composition. The rubber composition for the studless tire contains: a mixture of a zinc salt of an aliphatic carboxylic acid and a zinc salt of an aromatic carboxylic acid; an oil or a plasticizer; and a rubber component that comprises 40% by mass or more of a butadiene rubber relative to 100% by mass of a total amount of the rubber component.
US08859654B2 Heat stabilized polymeric composition with epoxidized fatty acid ester plasticizer
The present disclosure is directed to a polymeric composition containing a vinyl chloride resin and an epoxidized fatty acid ester. The polymeric composition also includes a heat stabilizing composition. The heat stabilizing composition includes a first metal salt, a second metal salt, and a β-diketone. The epoxidized fatty acid ester is the primary, or the sole, plasticizer in the polymeric composition. The present polymeric composition finds advantageous application as a coating for wire and cable.
US08859651B2 Blends of polysulfones and polyphenylene sulfide resins
Compositions including a blend of a) a polysulfone (PSU); b) a polyphenylene sulfide (PPS); and, c) a polyetherimide and epoxy. The polyetherimide and epoxy can be present in an amount effective to act as a compatibilizer for the polysulfone (PSU) and polyphenylene sulfide (PPS).Various embodiments relate to a method of compatibilizing a blend of polysulfone (PSU) and polyphenylene sulfide (PPS). The method can include a) melt mixing a polysulfone (PSU) and a polyetherimide; and b) melt mixing a polyphenylene sulfide (PPS) and an epoxy. Step a) and b) can be carried out by one of sequential mixing and simultaneous mixing.
US08859645B2 Fluoropolymer dispersion purification
The invention pertain to a process for purifying a fluoropolymer dispersion, said process comprising: (i) providing an aqueous dispersion (D) of at least one fluoropolymer [polymer (F)]comprising at least one fluorinated surfactant [surfactant (FS)], having a solids content (SC) of 15% by weight or more; (ii) adding to said aqueous dispersion (D) at least one non-ionic non-fluorinated surfactant [surfactant (NS)]; (iii) adjusting said solid content (SC) to less than 10% by weight, to obtain a diluted aqueous dispersion (dD); (iv) contacting said diluted aqueous dispersion (dD) with at least one adsorbing material, so as to obtain an aqueous dispersion of polymer (F) having a content of the fluorinated surfactant (FS) of less than 1 ppm based on the total weight of solids. Still an object of the invention is an aqueous fluoropolymer dispersion comprising less than 1 ppm of fluorinated surfactant.
US08859642B2 Curable composition, cured article obtained therefrom and process for preparation of the same
Fine polymer particles are dispersed as primary particles in a vinyl monomer to provide a high quality composition in which the dispersed state and stability of the particles are regulated to a high degree and to provide a curable composition being excellent in handleability and using fine polymer particles as a toughness-imparting agent. For the above, the curable composition of the present invention comprises 100 parts by weight of a vinyl monomer (A) and 0.1 to 100 parts by weight of fine polymer particles (B) having a volume average particle size of 0.05 to 1 m, in which the fine polymer particles (B) are dispersed in the form of primary particles in the vinyl monomer (A).
US08859640B2 Coloring ink for electrical wire
The present invention is to provide a coloring ink for an electrical wire to prevent a color irregularity. A coloring ink is ejected to an outer surface of an electrical wire with a certain amount of the ink to form a mark. The coloring ink contains 100 parts by weight of an ink material, which contains a solvent, an acrylic resin, and a coloring material, and 5-15 parts by weight of an aqueous PVA solution. A concentration of the aqueous PVA solution is 10-15 %.
US08859637B2 Hydrophilic agents in paints
Coating compositions that provide hydrophilic and anti-freeze properties are disclosed. The coatings include at least one hydrophilic agent bound to one or more coating components, such as a rheology modifier, a surfactant, a coalescing agent, and a pigment. The hydrophilic agents are attached to the coating components covalently.
US08859630B2 Operation of processes which employ a catalyst that deactivates over time
A method of operating a process for catalytically converting one or more reactants to one or more products using a fluid bed reactor containing a catalyst which deactivates over time includes, during a catalyst campaign, in a step A, gradually increasing an operating temperature of the reactor to counteract the negative effect of catalyst deactivation on a conversion rate of the one or more reactants. The operating temperature is not allowed to exceed a selected maximum operating temperature. Thereafter, in a step B, catalyst is added which has the tendency to increase the conversion rate of the one or more reactants into the reactor, and the operating temperature of the reactor is reduced to counteract to at least some extent the effect of the added catalyst on the conversion rate of the one or more reactants. The operating temperature remains above a selected minimum operating temperature during step B. Steps A and B are repeated until the end of the catalyst campaign or until the end of a production run.
US08859624B2 Stable rasagiline composition
The present invention provides a stable composition of rasagiline comprising an effective dosage of rasagiline or its pharmaceutically acceptable salts and an antioxidant used as a stabilizer. The dosage forms of the composition are pharmaceutically common transdermal-drug delivery dosage form and mucoadhesive delivery dosage form, such as patch, gel, ointment, cream, cataplasm, film, spray and solution, etc. The composition can be used to prevent or treat mental disorders.
US08859623B1 Methods and compositions of stable phenylephrine formulations
The invention is directed to methods and compositions of stabilizing phenylephrine formations. The composition has good time-dependent stability at low temperature and has no change in its outward appearance even after having been stored at least 6 months.
US08859622B1 Salts of physiologically active and psychoactive alkaloids and amines simultaneously exhibiting bioavailability and abuse resistance
Drug substances comprising a pharmaceutically acceptable organic acid addition salt of amine containing pharmaceutically active compounds useful for the treatment of a therapeutic ailment administration and exhibiting prophylactic properties when employed in non-therapeutic administration.
US08859619B2 Microbiologically sound and stable solutions of gamma-hydroxybutyrate salt for the treatment of narcolepsy
Disclosed are formulations of gamma-hydroxybutyrate in an aqueous medium that are resistant to microbial growth. Also disclosed are formulations of gamma-hydroxybutyrate that are also resistant to the conversion into GBL. Disclosed are methods to treat sleep disorders, including narcolepsy, with these stable formulations of GHB. The present invention also provides methods to treat alcohol and opiate withdrawal, reduced levels of growth hormone, increased intracranial pressure, and physical pain in a patient.
US08859617B2 Use of furan alkyl for preparing an antidiabetic drug
The invention relates to using one or several synthetic or natural furan alkyls for preparing a drug for preventing and/or treating diabetes and insulin resistance, thereby preventing the risks of cardiovascular, nervous, cutaneous, renal, ocular and infectious diseases. The use of one or several synthetic or natural furan alkyls for cosmetically treating diabetes related skin disorders is also disclosed.
US08859616B2 Compounds and methods for enhancing hair growth
The present invention provides a method for stimulating hair growth in a mammalian species or converting vellus hair or intermediate hair to terminal hair or stimulating hair follicles to increase hair growth and one or more properties selected from the group consisting of luster, sheen, brilliance, gloss, glow, shine or patina of hair associated with the follicles or increasing one or more of: length, thickness, number, and density, of eyelash hair or eyebrow hair comprising applying to the skin of a patient a composition comprising an effective amount of an EP3 agonist or an EP4 agonist prodrug or a mixture thereof. Such compositions which are used in treating the skin or scalp of a human or non-human animal may comprise an effective amount of 3, 7 or 3 and 7 thia prostanoic acid. A mixture of 3,7-dithia PGE1 and 3,7-dithia PGE1-isopropyl ester is preferred for this treatment.
US08859604B2 Crystals and process of making 5-({[2-amino-3-(4-carbamoyl-2,6-dimethyl-phenyl)-propionyl]-[1-(4-phenyl-1h-imidazol-2-yl)-ethyl]-amino}-methyl)-2-methoxy-benzoic acid
The present invention relates to a novel crystals of 5-({[2-amino-3-(4-carbamoyl-2,6-dimethyl-phenyl)-propionyl]-[1-(4-phenyl-1h-imidazol-2-yl)-ethyl]-amino}-methyl)-2-methoxy-benzoic acid and methods of making the zwitterion of 5-({[2-amino-3-(4-carbamoyl-2,6-dimethyl-phenyl)-propionyl]-[1-(4-phenyl-1h-imidazol-2-yl)-ethyl]-amino}-methyl)-2-methoxy-benzoic acid.
US08859602B2 Inhibitors of c-fms kinase
The invention is directed to compounds of Formula I: wherein Z, X, J, R2 and W are set forth in the specification, as well as solvates, hydrates, tautomers and pharmaceutically acceptable salts thereof, that inhibit protein tyrosine kinases, especially c-fms kinase. Methods of treating autoimmune diseases; and diseases with an inflammatory component; treating metastasis from ovarian cancer, uterine cancer, breast cancer, prostate cancer, lung cancer, colon cancer, stomach cancer, hairy cell leukemia; and treating pain, including skeletal pain caused by tumor metastasis or osteoarthritis, or visceral, inflammatory, and neurogenic pain; as well as osteoporosis, Paget's disease, and other diseases in which bone resorption mediates morbidity including rheumatoid arthritis, and other forms of inflammatory arthritis, osteoarthritis, prosthesis failure, osteolytic sarcoma, myeloma, and tumor metastasis to bone with the compounds of Formula I, are also provided.
US08859595B2 Potent and selective inhibitors of hepatitis C virus
The present invention is directed to compounds, compositions and methods for treating or preventing hepatitis C virus (HCV) infection in human subjects or other animal hosts. The compounds are as also pharmaceutically acceptable, salts, prodrugs, and other derivatives thereof as pharmaceutical compositions and methods for treatment or prevention of HCV infection.
US08859588B2 Substituted N-heteroaryl bipyrrolidine carboxamides, preparation and therapeutic use thereof
The present disclosure relates to a series of substituted N-heteroaryl bipyrrolidine carboxamides of formula (I). wherein R1, R2, R3, R4, Q1, Q2, Q3, Q4, X, m and p are as described herein. More specifically, the compounds of this invention are modulators of H3 receptors and are, therefore, useful as pharmaceutical agents, especially in the treatment and/or prevention of a variety of diseases modulated by H3 receptors including diseases associated with the central nervous system. Additionally, this disclosure also relates to methods of preparation of substituted N-heteroaryl bipyrrolidine carboxamides of formula (I) and intermediates therefor.
US08859587B2 (2E)-3-phenyl-N-[2,2,2-Trifluoro-1-[[8-quinolineamino)thiomethyl]amino]ethyl]-2-acrylamide and pharmaceutical uses thereof
The present invention relates to an acrylamide compound of Formula I, or an isomer, pharmaceutically acceptable salt and solvate thereof, to a composition comprising the compound or an isomer, pharmaceutically acceptable salt and solvate thereof, and a pharmaceutically acceptable carrier, excipient or diluent, and to a use of the compound or the composition for prophylaxis and/or treatment of a disease or disorder associated with cardiomyocyte apoptosis.
US08859585B2 Scopolamine for the treatment of depression and anxiety
Provided are methods and compositions for the treatment of depression and anxiety. The compositions contain scopolamine, or an analog thereof, and can optionally include one or more psychoactive agents. Further provided is an inhaler containing scopolamine, or an analog thereof, in a pharmaceutically acceptable carrier.
US08859581B2 Azaheterocyclic compounds as kinase inhibitors
The invention relates to compounds of the formula (I), to the preparation and use thereof for the preparation of a medicament for the treatment of diseases, in particular tumors and/or diseases in the development or course of which kinases are involved.
US08859578B2 Natural product derivatives with antiprotozoal activity
The present invention provides new chemical compositions with desirable biological activity and toxicity profiles for the enhanced treatment of malaria.
US08859575B2 Benzoimidazol-2-yl pyrimidine modulators of the histamine h4 receptor
Benzoimidazol-2-yl pyrimidines, purification methods for the same, and pharmaceutical compositions and methods for the treatment of disease states, disorders, and conditions mediated by H4 receptor activity, including allergy, asthma, autoimmune diseases, and pruritus.
US08859573B2 Pyrimidinone and pyridinone compounds for use in the treatment of diseases or conditions mediated by Lp-PLA2
The present invention relates to novel compounds that inhibit Lp-PLA2 activity, processes for their preparation, to compositions containing them and to their use in the treatment of diseases associated with the activity of Lp-PLA2, for example atherosclerosis, Alzheimer's disease, and/or diabetic macular edema.
US08859572B2 Sulfone substituted 2,3-dihydroimidazo [1,2-C] quinazoline derivatives useful for treating hyper-proliferative disorders and diseases with angiogenesis
This invention relates to novel sulfone 2I3-dihydroimidazo[1 l2-c]quinazoline compounds, pharmaceutical compositions containing such compounds and the use of those compounds or compositions for phosphotidylinositol-3-kinase (PI3K) inhibition and treating diseases associated with phosphotidylinositol-3-kinase (PI3K) activity, in particular treating hyper-proliferative and/or angiogenesis mediated disorders, as a sole agent or in combination with other active ingredients.
US08859568B2 Pyrrolo[3,2-D]pyrimidin-4-one derivatives and their use in therapy
There are disclosed novel compounds of formula (I) wherein R1, R12, L, X and Y are as defined in the specification, and pharmaceutically acceptable salts thereof; together with processes for their preparation, compositions containing them and their use in therapy. The compounds are inhibitors of the enzyme MPO and are thereby particularly useful in the treatment or prophylaxis of neuroinflammatory disorders, cardiovascular disorders and respiratory disorders.
US08859565B2 Compound for inhibiting type 5 phosphodiesterase and preparation method thereof
The present invention discloses a compound of formula (I) and citrate thereof as type 5 phosphodiesterase inhibitor, a preparation method thereof, and a pharmaceutical composition including the compound of formula (I) and citrate thereof. The experimental results of the present invention prove that the compound of formula (I) and citrate thereof can inhibit activity of type 5 phosphodiesterase, and can be used for treating erectile dysfunction, inhibiting platelet aggregation and treating thrombosis, decreasing pulmonary hypertension and treating cardiovascular diseases, treating asthma and treating diabetes gastroparesis.
US08859564B2 Pyrazolo[3,4-d]pyrimidine-4,6(5H,7H)-dione derivatives useful as inhibitors of phosphodiesterase 1
Optionally substituted (5- or 7-amino)-3,4-dihydro-(optionally 4-oxo, 4-thioxo or 4-imino)-1H-pyrrolo[3,4-d]pyrimidin-2(6H)-ones, Compounds of Formula I, processes for their production, their use as pharmaceuticals and pharmaceutical compositions comprising them.
US08859562B2 Use of RNAI inhibiting PARP activity for the manufacture of a medicament for the treatment of cancer
The present invention relates to the use of an agent that inhibits the activity of an enzyme that mediates repair of a DNA strand break in the manufacture of a medicament for the treatment of diseases caused by a defect in a gene that mediates homologous recombination.
US08859558B2 Pyrazinyl carboxamides as fungicides
This present disclosure is related to the field of pyrazine carboxamides and their derivatives and the use of these compounds as fungicides.
US08859554B2 Packaging assembly for pharmaceutical composition including pimobendan
A packaging assembly or kit includes packaging material containing a solid formulation including pimobendan dispersed in a polyvalent acid. The kit may also include a package leaflet or user instruction including the information concerning use of the solid formulation, for example, via the oral route for the prevention and/or treatment of congestive heart failure in a mammal in need of such prevention or treatment, preferably in a dog, cat or rodent.
US08859553B2 Protein kinase inhibitors
The present invention relates to compounds of Formula I: as well as pharmaceutically acceptable salts, hydrates, isomers, or solvates thereof, wherein the variables are described herein. The present invention further relates to pharmaceutical compositions which comprise the compounds of Formula I, and to methods for inhibiting protein kinase and methods of treating diseases, such as cancers, inflammation.
US08859550B2 Heterocyclic inhibitors of histamine receptors for the treatment of disease
The present invention relates to salts, hydrates, and polymorphs of bicyclic heteroaryl compounds, and pharmaceutical compositions thereof, which may be useful as inhibitors of H4R for the treatment or prevention of diseases including allergic rhinitis.
US08859549B2 Potassium channel modulators
Disclosed herein are KCNQ potassium channels modulators of formula (I) wherein ring G1, R1, and R2 are as defined in the specification. Compositions comprising such compounds; and methods for treating conditions and disorders using such compounds and compositions are also described.
US08859548B2 Compounds and compositions as protein kinase inhibitors
The present invention provides compounds of Formula I or II: wherein R1, R1b, R2, R3, R4, R5, R6 and R7 are defined herein. The compounds of Formula (I) or (II) and pharmaceutical compositions thereof are useful for the treatment of B-Raf-associated diseases.
US08859546B2 Picolinamide inhibitors of kinases
The present invention relates to compounds of formula (I) or pharmaceutical acceptable salts, wherein R1, R2, R3, A, B, Z, n, and m are defined in the description. The present invention relates also to compositions containing said compounds which are useful for inhibiting kinases such as ALK and methods of treating diseases such as cancer.
US08859544B2 Indolizine derivatives, process for the preparation thereof and therapeutic use thereof
The invention relates to compounds corresponding to formula (I): in which R3 and R4 together form, with the carbon atoms of the phenyl nucleus to which they are attached, a 6-membered nitrogenous heterocycle corresponding to one of formula (A), (B) or (C) below: in which the wavy lines represent the phenyl nucleus to which R3 and R4 are attached. Preparation process and therapeutic use.
US08859534B2 2-carboxamide-7-piperazinyl-benzofuran derivatives
The present invention relates to compounds of formula (I), wherein R1 is heteroaryl or heterocyclyl, optionally substituted; R2 is C1-4alkyl, heterocyclyl, C1-4alkylaryl, C1-4alkylheteroaryl, carbocyclyl, C1-4alkylheterocyclyl, heterocyclyl-heteroaryl, aryl-heterocyclyl, carbocyclyl-heteroaryl, heterocyclyl-aryl, optionally substituted; R3 is hydrogen or C1-4alkyl, or R2 and R3 may together with the nitrogen atom, form a saturated ring system containing 4, 5 or 6 ring forming atoms, and optionally substituted; R4 is hydrogen, halogen, methyl or methoxy; to pharmaceutical composition containing said compounds and to the use of said compounds in therapy, for instance in treating cognitive disorders. The present invention further relates to new intermediates useful in the preparation thereof.
US08859532B2 Materials and method for inhibiting replication protein A and uses thereof
Targeting uncontrolled cell proliferation and resistance to DNA damaging chemotherapeutics with at least one reagent has significant potential in cancer treatment. Replication Protein A, the eukaryotic single-strand (ss) DNA binding protein, is essential for genomic maintenance and stability via roles in both DNA replication and repair. Reported herein are small molecules that inhibits the in vitro, in vivo, and cellular ssDNA binding activity of RPA, thereby disrupting the eukaryotic cell cycle, inducing cytotoxicity and increasing the efficacy of chemotherapeutic agents damage DNA, and/or disrupt its replication and/or function. These results provide new insights into the mechanism of RPA-ssDNA interactions in chromosome maintenance and stability. This represents a molecularly targeted eukaryotic DNA binding inhibitor and demonstrates the utility of targeting a protein-DNA interaction as a means of studying the cell cycle and providing a therapeutic strategy for cancer treatment.
US08859530B2 Co-administration of steroids and zoledronic acid to prevent and treat osteoarthritis
A combination therapy for treating osteoarthritis is disclosed. The combination therapy includes the co-administration of a steroid and Zoledronic Acid. The coadministration of a steroid decreases the production of cytokines, and, therefore, decreases the pro-inflammatory effects of Zoledronic Acid. The co-administration of Zoledronic Acid with steroids treats osteoarthritis, and helps to prevent the onset of osteoarthritis in patients at risk for osteoarthritis.
US08859528B2 Compositions and methods for modulation of vascular structure and/or function
The present invention relates to compositions comprising semi-crystalline β-1-4-N-acetylglucosamine polymers (p-GlcNac) and methods utilizing such polymers modulation of vascular structure and/or function. The compositions and methods disclosed are useful for stimulating, in a p-GlcNac concentration-dependent manner, endothelin-1 release, vasoconstriction, and/or reduction in blood flow out of a breached vessel, as well as for contributing to or effecting cessation of bleeding. The methods of the present invention comprise topical administration of materials comprising semi-crystalline p-GlcNac polymers that are free of proteins, and substantially free of single amino acids as well as other organic and inorganic contaminants, and whose constituent monosaccharide sugars are attached in a β-1-4 conformation.
US08859527B2 Inclusion complex of deoxypodophyllotoxin of cyclodextrin, preparation method, use for treatment of cancer thereof
Inclusion complex of deoxypodophyllotoxin of cyclodextrin, the preparation method and the use for the treatment of cancer thereof are disclosed. The inclusion complex consists of deoxypodophyllotoxin and beta-cyclodextrin derivative, wherein the molar ration of deoxypodophyllotoxin to beta-cyclodextrin derivative is 1:1-1:10. The beta-cyclodextrin derivative is sulfobutyl ether-beta-cyclodextrin or hydroxypropyl-beta-cyclodextrin.
US08859525B2 Pharmaceutical compositions comprising mushroom-based polysaccharides and uses thereof
A composition for providing relief to a discomfort of an eye comprises a pharmaceutically acceptable carrier and a polysaccharide extracted from a plant source. In certain embodiments, such a polysaccharide can be extracted from mushrooms, such as from the Tremella fuciformis species. The composition is administered to an affected eye to provide such relief or discomfort.
US08859522B2 Processes for the preparation of regadenoson and a new crystalline form thereof
This disclosure relates to an improved process for the preparation of regadenoson, pharmaceutically acceptable salts thereof, and hydrates thereof, and for the preparation of intermediates useful in the synthesis of regadenoson. The disclosure also relates to a new crystalline form of regadenoson. Processes for the preparation of the crystalline form, compositions containing the crystalline form, and methods of use thereof are also described.
US08859517B2 Method of gene transfer for the treatment of recessive catecholaminergic polymorphic ventricular tachycardia (CPVT)
The present invention concerns a method for the treatment of recessive Catecholaminergic Polymorphic Ventricular Tachycardia comprising delivering a gene into a cardiac cell.
US08859512B2 Anti-viral pyrimidine nucleoside derivatives
A compound for use in the treatment or prophylaxis of viral infections such, for example as chicken pox or shingles caused by the Varicella Zoster virus, said compound having the general formula (II): wherein X is O, S, NH or CH2, Y is O, S or NH, Z is O, S or CH2, R1 is C1-6 alkyl, preferably n-alkyl, e.g., n-pentyl or n-hexyl, and one of R2 and R3 is OH, and the other of R3 and R2 is a neutral, non-polar amino acid moiety, or a pharmaceutically acceptable salt or hydrate thereof. Said neutral, non-polar amino acid moiety R2 or R3 may be (IV): in which R4, R5, R6 and R7 are each independently H or C1-2 alkyl. In preferred embodiments, one of R2 or R3 is valine, leucine, isoleucine or alanine, particularly valine.
US08859505B2 Cysteine protease inhibitors
Compounds of the formula I wherein R2a and R2b are independently H, halo, C1-C4alkyl, C1-C4haloalkyl or C1-C4alkoxy, or R2a and R2b together with the carbon atom to which they are attached form a C3-C6cycloalkyl; R3 is a C5-C10 alkyl, optionally substituted with 1-3 substituents independently selected from halo, C1-C4haloalkyl, C1-C4alkoxy, C1-C4haloalkoxy; or R3 is a C2-C4alkyl chain with at least 2 chloro or 3 fluoro substituents; or R3 is C3-C7cycloalkylmethyl, optionally substituted with 1-3 substituents independently selected from C1-C4alkyl, halo, C1-C4haloalkyl, C1-C4alkoxy, C1-C4haloalkoxy; R4 is C1-C6alkyl, C1-C6haloalkyl, C1-C6alkoxy, C1-C6haloalkoxy, C1-C6alkylamino, C1-C6dialkylamino or; R4 is Het or Carbocyclyl, either of which is optionally substituted with 1-3 substituents R4 is Het, carbocyclyl, C1-C6alkyl, C1-C6haloalkyl, C1-C6alkoxy or C1-C6haloalkoxy; n is 1, 2 or 3; for the use in the prophylaxis or treatment of a disorder characterised by inappropriate expression or activation of cathepsin S.
US08859504B2 Boronate ester compounds and pharmaceutical compositions thereof
The present invention provides novel compounds useful as proteasome inhibitors. The invention also provides pharmaceutical compositions comprising the compounds of the invention and methods of using the compositions in the treatment of various diseases.
US08859502B2 Therapy for MLL-rearranged leukemia
Provided are methods for treating MLL-rearranged ALL by administering to a patient an HDAC inhibitor alone or in combination with a DNA demethylating agent. Also provided are methods of treating MLL-rearranged infant ALL. Methods of treating cells by these agents are also provided. Additionally, disclosed is a method for screening for compounds capable to treat MLL-rearranged ALL, in particular, MLL-rearranged infant ALL. In one embodiment, the HDAC inhibitor is romidepsin.
US08859500B2 Method for ameliorating pain by modification of NMDA receptors through inhibition of SRC
The present invention provides a method for ameliorating inflammatory and/or neuropathic pain in a subject by modifying the activity of N-methyl-D-aspartate (NMDA) receptors in cells of the subject by inhibition of the interaction of the unique domain of the tyrosine kinase Src enzyme and the NMDA receptor complex.
US08859497B2 Method of treatment using cysteine mutants of beta interferon
The growth hormone supergene family comprises greater than 20 structurally related cytokines and growth factors. A general method is provided for creating site-specific, biologically active conjugates of these proteins. The method involves adding cysteine residues to non-essential regions of the proteins or substituting cysteine residues for non-essential amino acids in the proteins using site-directed mutagenesis and then covalently coupling a cysteine-reactive polymer or other type of cysteine-reactive moiety to the proteins via the added cysteine residue. Disclosed herein are preferred sites for adding cysteine residues or introducing cysteine substitutions into the proteins, and the proteins and protein derivatives produced thereby. Also disclosed are therapeutic methods for using the cysteine variants of the invention.
US08859493B2 Insulin derivatives
The present invention is related to insulin derivatives having a side chain attached either to the α-amino group of the N-terminal amino acid residue of B chain or to an ε-amino group of a Lys residue present in the B chain of the parent insulin molecule via an amide bond which side chain comprises one or more residues of ethyleneglycol, propyleneglycol and/or butyleneglycol containing independently at each termini a group selected from —NH2 and —COOH; a fatty diacid moiety with 4 to 22 carbon atoms, at least one free carboxylic acid group or a group which is negatively charged at neutral pH; and possible linkers which link the individual components in the side chain together via amide or ether bonds, said linkers optionally comprising a free carboxylic acid group.
US08859489B2 Water-mediated control of depolymerization step of glatiramer acetate synthesis
Methods of making copolymers are described.
US08859488B2 Peptide analogs capable of enhancing stimulation of a glioma-specific CTL response
The invention provides a peptide derived from the interleukin-13 receptor α2, which serves as a HLA-A2-restricted cytotoxic T lymphocyte (CTL) epitope. The invention can be used as a vaccine for glioma and can be formulated into compositions for medical or veterinary use. In addition, the invention provides the use of a peptide derived from the Eph family of tyrosine kinase receptors which can be also used as a vaccine for glioma and can be formulated into compositions for medical or veterinary use.
US08859487B2 Perfume testers or perfumes
A perfume tester or perfume includes a granule containing a friable peripheral portion incorporating fragrant compounds, which disintegrates as a perfumed powder when the granule is applied onto the skin. A method for making the perfume tester or perfume is by granulation, and the granule can be used in particular for perfume testing.
US08859486B2 Anhydrous detergent composition comprising a clay mixture processed with quaternary ammonium salts
An anhydrous composition comprising a liquid phase, a dispersed solid phase and a processed clay mixture. The composition has a minimum amount of water and is surprisingly stable during its long-term storage, with no phase separation and minimal activated oxygen loss.
US08859485B2 Ethylene acrylic acid copolymer aqueous dispersions for fragrance release in laundry detergents
Described are fabric care compositions, comprising a builder and an aqueous dispersion comprising an ethylene acrylic acid copolymer and a fragrance.
US08859482B2 Method for preparing a solid form of acetic acid and products thereof
The present invention discloses a method of preparing a solid form of acetic acid. The method at least includes the steps of combining a solid acid and a metal acetate with a solvent to form a slurry. After a predetermined period of time, a solid form of acetic acid is recovered. The present invention also includes a solid product of acetic acid produced by the above-mentioned method. There is also disclosed a formulation including the solid product of acetic acid according to the present invention. Further, there is disclosed a cleaning system including the formulation according to the present invention.
US08859479B2 Chemical stripping composition and method
A stripping solution comprises a highly corrosive acid and an iron concentration of at least about 1.0 gram per liter (g/L). The stripping solution is air agitated to remove a coating from a metal article submerged therein.
US08859476B2 Multi-purpose, non-corrosive cleaning compositions and methods of use
Compositions comprising an alkanesulfonic acid and an organic nitrogenous base, and related methods of use.
US08859464B2 Nitrogen containing isethionic acid salts in field ready spray and tank mixes
Embodiments of the present invention disclose an agricultural composition that is a field ready spray or a tank mix that includes at least one nitrogen containing isethionic acid salt, at least one agriculturally active ingredient, and at least one surfactant.
US08859463B2 Method for controlling noxious organisms
A control method against noxious organisms in a field of soybean or corn, which comprises applying one or more PPO-inhibiting compounds selected from the group consisting of flumioxazin, sulfentrazone, saflufenacil, oxyfluorfen and 3-(4-chloro-6-fluoro-2-trifluoromethylbenzimidazol-7-yl)-1-methyl-6-trifluoromethyl-2,4-(1H,3H)pyrimidinedione to soil or weeds in the field where soybean or corn seeds have been sown or where said seeds are to be sown, said seeds being treated with one or more compounds selected from the group consisting of neonicotinoid compounds, azole compounds, strobilurin compounds and metalaxyl compounds.
US08859462B2 Pest control composition
Disclosed is a pest control composition comprising at least one pyripyropene derivative of formula (I) or agriculturally and horticulturally acceptable salt thereof and at least one other pest control agent as active ingredients. The combined use of the two ingredients can provide a better insecticidal effect.
US08859458B2 Methods of preparing electrocatalysts for fuel cells in core-shell structure and electrocatalysts
Provided are a method of preparing an electrocatalyst for fuel cells in a core-shell structure, an electrocatalyst for fuel cells having a core-shell structure, and a fuel cell including the electrocatalyst for fuel cells. The method may be useful in forming a core and a shell layer without performing a subsequent process such as chemical treatment or heat treatment and forming a core support in which core particles having a nanosize diameter are homogeneously supported, followed by selectively forming shell layers on surfaces of the core particles in the support. Also, the electrocatalyst for fuel cells has a high catalyst-supporting amount and excellent catalyst activity and electrochemical property.
US08859454B2 Diesel oxidation catalyst with good low-temperature activity
The invention relates to a method for producing a catalyst, wherein the catalyst has a high activity and selectivity with regard to the oxidation of CO and NO. The invention also relates to the catalyst produced using the method according to the invention, the use of the catalyst as oxidation catalyst as well as a catalyst component which contains the catalyst according to the invention. Finally, the invention is directed towards an exhaust-gas cleaning system which comprises the catalyst component containing the catalyst according to the invention.
US08859453B2 Implantation of Ni nano domains in refractory metal oxide support by means of sol-gel encapsulation—an effective solution to coke formation in the partial oxidation of natural gas
A metal oxide-supported nickel catalyst includes a matrix containing a metal oxide and catalytic sites distributed throughout the matrix and having an intricate interface with the matrix, in which the catalytic sites are selected from the group consisting of nano-nickel(0) domains and nano-nickel(0)-A(0) alloy domains. Also disclosed are a method for preparing this catalyst and a method for using it to produce carbon monoxide and hydrogen by partial oxidation of a C1-C5 hydrocarbon.
US08859452B2 Metal cyanide complex catalyst and its preparation and application
A metal cyanide complex catalyst and its preparation and application are disclosed. The formula of this catalyst is M1a[M2(CN)bL1c]d(X)m(L2)n.xSu.yL3.zH2O and its preparation method comprises: (A) adjusting pH of a mixed solution I′ of L3, M3e[M2(CN)bL1c]f, de-ionized water I, alcohol and/or ether solvent to less than 7.0, and adding it into a mixed solution II′ of M1(X)g salt, Su or Su precursor, de-ionized water II, stirring for reaction under 20° C.-120° C. for 0.5-200 hours, separating and drying to obtain a solid product; and (B) repeatedly dispersing the solid into an anhydrous organic solvent containing L2 to form a slurry, distilling, separating and drying to obtain the metal cyanide complex catalyst. The catalyst is useful in preparing polyethers, polycarbonates and polyesters by homopolymerization of epoxides, or copolymerization of epoxides with carbon dioxide or anhydrides.
US08859451B2 Process for the preparation of supported catalysts
The present invention refers to a process for the preparation of supported catalysts for the polymerization of olefins comprising at least a late transition metal complex, wherein the process comprises two steps. In the first step a catalytically active component comprising at least one late transition metal complex, optionally in the presence of one or more cocatalysts is mixed with a support; and in the second step the obtained mixture is treated at a reduced pressure under a flow of inert gas at a temperature equal to or below 40° C. to obtain a supported catalyst. The method is especially useful for the preparation of dual supported catalysts, useful in the gas-phase polymerization of olefins.
US08859450B2 Solid catalyst component for olefin polymerization
A solid catalyst component for olefin polymerization, comprising titanium atoms, magnesium atoms, halogen atoms and hydrocarbyloxy groups, wherein the following filtrate contains titanium atoms in a concentration of 0.08 mg-Ti/ml-filtrate or lower, measured according to a method comprising the steps of (1) preparing a suspension of the solid catalyst component for olefin polymerization in heptane having a concentration of 0.1 g-solid catalyst component/ml-suspension, (2) heating the suspension at 70° C. for 30 minutes under stirring, (3) filtering the suspension, thereby obtaining a filtrate, and (4) measuring a concentration of titanium atoms contained in the filtrate; and a production process of the solid catalyst component.
US08859448B2 Binderless zeolitic adsorbents, methods for producing binderless zeolitic adsorbents, and processes for adsorptive separation of para-xylene from mixed xylenes using the binderless zeolitic adsorbents
Binderless BaKX zeolitic adsorbents, methods for their production, and processes for their use in a liquid phase adsorptive separation process are provided. An adsorbent includes a binder-converted zeolite portion formed from x wt % kaolin clay binder and (100−x) wt % unconverted Zeolite X with a silica:alumina molar ratio of about 2.5. The kaolin clay binder is in the range of about 10 to about 20 wt %. Ba and K occupy cationic exchangeable sites within the adsorbent. K is in the range of about 0.25 to about 0.9% by weight and Ba is greater than about 31.6% by weight of the binderless BaKX zeolitic adsorbent. Cornstarch may be added to the Zeolite X and kaolin clay binder to increase adsorbent macro-porosity and pore volume. Productivity of the adsorbent is improved decreasing process operating costs. The mechanical strength of the adsorbent is also improved.
US08859446B2 α alumina sintered body for production of sapphire single crystal
A method for producing an α alumina sintered body for the production of a sapphire single crystal characterized in that a relative density is 60% or more, a closed porosity is 10% or less, a purity is 99.99% by mass or more, each content of Si, Na, Ca, Fe, Cu and Mg is 10 ppm or less, and a volume is 1 cm3 or more, and the α alumina sintered body can be obtained by mixing 100 parts by weight of an α alumina with 1 part by weight or more and 20 parts by weight or less of an α alumina precursor to obtain a mixture, forming a compact from the obtained mixture, and firing the obtained compact.
US08859444B2 Optical glass, press-molding glass material, optical element and process for producing the same
A high-refractivity low-dispersion optical glass of which the Ta2O5 content is suppressed is provided, the optical glass comprising, by mass %, 1 to 30% of B2O3, 0.1 to 20% of SiO2, 55 to 75% of a total of La2O3, Gd2O3, Y2O3 and Yb2O3, the content of La2O3 being 15 to 55%, the mass ratio of the content of Gd2O3 to the total content of La2O3, Gd2O3, Y2O3 and Yb2O3, Gd2O3/La2O3+Gd2O3+Y2O3+Yb2O3), being 0.17 to 0.65, 0 to 13% of Ta2O5 (exclusive of 13%), and 0 to 25% of a total of Nb2O5, TiO2, WO3 and ZrO2, the content of Nb2O5 being less than 10%, and having a refractive index nd of 1.83 to 1.92 and an Abbe's number νd of 36 to 45.
US08859437B2 Solution for etching a thin film transistor and method of manufacturing the same
Disclosed herein is an aqueous alkaline etching solution comprising water and an alkaline material being selected from the group consisting of ammonium hydroxide, ammonium phosphate, ammonium carbonate, quaternary ammonium hydroxide, quaternary ammonium phosphate, quaternary ammonium carbonate, an alkali metal hydroxide, an alkaline earth metal hydroxide, or a combination comprising at least one of the foregoing alkaline materials; the aqueous alkaline solution being operative to etch aluminum oxide at a rate greater than or equal to about 2:1 over a rate at which it etches a metal oxide semiconductor to be protected; wherein the aqueous etching solution has a pH of 8 to 13.
US08859436B2 Uniform large-grained and grain boundary location manipulated polycrystalline thin film semiconductors formed using sequential lateral solidification and devices formed thereon
Methods for processing an amorphous silicon thin film sample into a polycrystalline silicon thin film are disclosed. In one preferred arrangement, a method includes the steps of generating a sequence of excimer laser pulses, controllably modulating each excimer laser pulse in the sequence to a predetermined fluence, masking portions of each fluence controlled laser pulse in the sequence with a two dimensional pattern of slits to generate a sequence of fluence controlled pulses of line patterned beamlets, irradiating an amorphous silicon thin film sample with the sequence of fluence controlled slit patterned beamlets to effect melting of portions thereof, and controllably sequentially translating a relative position of the sample with respect to each of the fluence controlled pulse of slit patterned beamlets to thereby process the amorphous silicon thin film sample into a single or polycrystalline silicon thin film.
US08859427B2 Formation of a zinc passivation layer on titanium or titanium alloys used in semiconductor processing
Embodiments of the current invention describe methods of processing a semiconductor substrate that include applying a zincating solution to the semiconductor substrate to form a zinc passivation layer on the titanium-containing layer, the zincating solution comprising a zinc salt, FeCl3, and a pH adjuster.
US08859425B2 Devices, systems, and methods related to forming through-substrate vias with sacrificial plugs
Methods for making semiconductor devices are disclosed herein. A method configured in accordance with a particular embodiment includes forming one or more openings in a front side of the semiconductor device and forming sacrificial plugs in the openings that partially fill the openings. The method further includes further filling the partially filled openings with a conductive material, where individual sacrificial plugs are generally between the conductive material and a substrate of the semiconductor device. The sacrificial plugs are exposed at a backside of the semiconductor device. Contact regions can be formed at the backside by removing the sacrificial plugs.
US08859424B2 Semiconductor wafer carrier and method of manufacturing
A system and method for a semiconductor wafer carrier is disclosed. An embodiment comprises a semiconductor wafer carrier wherein conductive dopants are implanted into the carrier in order to amplify the coulombic forces between an electrostatic chuck and the carrier to compensate for reduced forces that result from thinner semiconductor wafers. Another embodiment forms conductive layers and vias within the carrier instead of implanting conductive dopants.
US08859420B2 Structure and method of making interconnect element, and multilayer wiring board including the interconnect element
A method of fabricating an interconnect element may include fabricating a metal layer that overlies a carrier layer and that includes a plurality of metal traces; providing a dielectric element to overlie the metal layer and the carrier layer; providing a plurality of metal posts; and removing the carrier layer to expose the first major surface of the dielectric element and the outer surfaces of the plurality of metal traces.
US08859418B2 Methods of forming conductive structures using a dual metal hard mask technique
Disclosed herein are various methods of forming conductive structures, such as conductive lines and vias, using a dual metal hard mask integration technique. In one example, the method includes forming a first layer of insulating material, forming a first patterned metal hard mask layer above the first layer of insulating material, forming a second patterned metal hard mask layer above the first patterned metal hard mask layer, performing at least one etching process through both of the second patterned metal hard mask layer and the first patterned metal hard mask layer to define a trench in the first layer of insulating material and forming a conductive structure in the trench.
US08859416B2 Software and method for via spacing in a semiconductor device
A computer-readable software product is provided for executing a method of determining the location of a plurality of power rail vias in a semiconductor device. The semiconductor device includes an active region and a power rail. Locations of a first via and a second via are assigned along the power rail. The spacing between the location of the first via and the location of the second via is a minimum spacing allowable. The spacing between the location of the second via and the locations of structures in the active region which may electrically interfere with the second via is determined. The location of the second via is changed in response to the spacing between the location of the second via and the location of one of the structures in the active region being less than a predetermined distance.
US08859414B2 Electronic assemblies including mechanically secured protruding bonding conductor joints
A method for joining integrated circuit (IC) die. The includes pressing the IC die toward a workpiece so that a protruding bonding feature is inserted into a cavity of a receptacle through an opening. The pressing bends peripheral shelf regions downward into the cavity and towards sidewall portions of the receptacle to form bent peripheral shelf regions. A protruding bonding feature contacts the bent peripheral shelf regions along a contact area. The contact area being at least primarily along the sidewall surfaces of the protruding bonding feature.
US08859413B2 Method of growing gan crystal on silicon substrate, and light emitting device and method of manufacturing thereof
Example embodiments are directed to a method of growing GaN single crystals on a silicon substrate, a method of manufacturing a GaN-based light emitting device using the silicon substrate, and a GaN-based light emitting device. The method of growing the GaN single crystals may include forming a buffer layer including a TiN group material or other like material on a silicon substrate, forming a nano-pattern including silicon oxide on the buffer layer, and growing GaN single crystals on the buffer layer and the nano-pattern.
US08859408B2 Stabilized metal silicides in silicon-germanium regions of transistor elements
Generally, the present disclosure is directed to methods of stabilizing metal silicide contact regions formed in a silicon-germanium active area of a semiconductor device, and devices comprising stabilized metal silicides. One illustrative method disclosed herein includes performing an activation anneal to activate dopants implanted in an active area of a semiconductor device, wherein the active area comprises germanium. Additionally, the method includes, among other things, performing an ion implantation process to implant ions into the active area after performing the activation anneal, forming a metal silicide contact region in the active area, and forming a conductive contact element to the metal silicide contact region.
US08859405B2 Method of fabricating high efficiency CIGS solar cells
A method for fabricating high efficiency CIGS solar cells including the deposition of Ga concentrations (Ga/(Ga+In)=0.25−0.66) from sputtering targets containing Ga concentrations between about 25 atomic % and about 66 atomic %. Further, the method includes a high temperature selenization process integrated with a high temperature anneal process that results in high efficiency.
US08859400B2 Gallium nitride devices with conductive regions
Semiconductor structures comprising a III-nitride (e.g., gallium nitride) material region and methods associated with such structures are provided. In some embodiments, the structures include an electrically conductive material (e.g., gold) separated from certain other region(s) of the structure (e.g., a silicon substrate) by a barrier material in order to limit, or prevent, undesirable reactions between the electrically conductive material and the other component(s) which can impair device performance. In certain embodiments, the electrically conductive material may be formed in a via. For example, the via can extend from a topside of the device to a backside so that the electrically conductive material connects a topside contact to a backside contact. The structures described herein may form the basis of a number of semiconductor devices including transistors (e.g., FET), Schottky diodes, light-emitting diodes and laser diodes, amongst others.
US08859399B2 Method of at least partially releasing an epitaxial layer
A method of at least partially releasing an epitaxial layer of a material from a substrate. The method comprises the steps of: forming a patterned sacrificial layer on the substrate such that the substrate is partially exposed and partially covered by the sacrificial layer; growing the epitaxial layer on the patterned sacrificial layer by nano-epitaxial lateral overgrowth such that the epitaxial layer is formed above an intermediate layer comprising the patterned sacrificial layer and said material; and selectively etching the patterned sacrificial layer such that the epitaxial layer is at least partially released from the substrate.
US08859395B2 Techniques for curvature control in power transistor devices
Techniques for processing power transistor devices are provided. In one aspect, the curvature of a power transistor device comprising a device film formed on a substrate is controlled by thinning the substrate, the device having an overall residual stress attributable at least in part to the thinning step, and applying a stress compensation layer to a surface of the device film, the stress compensation layer having a tensile stress sufficient to counterbalance at least a portion of the overall residual stress of the device. The resultant power transistor device may be part of an integrated circuit.
US08859389B2 Methods of making fins and fin field effect transistors (FinFETs)
Methods of making fins and semiconductor structures containing fins are provided. The methods involve forming a multi-layer structure over a semiconductor substrate. The multi-layer structure comprises a first layer over the semiconductor substrate, a second layer over the first layer, and a third layer over the second layer. The method also comprises removing upper portions of the semiconductor substrate and portions of the multi-layer structure to form fins of the semiconductor substrate and portions of the multi-layer structure. Further, the method comprises selectively oxidizing the first layer while oxidization of the second layer and the third layer is less than the oxidization of the first layer. The oxidation can be performed before gap fill recess or after gap fill recess.
US08859385B1 Method of fabricating semiconductor device
A method of fabricating a semiconductor device includes providing a semiconductor substrate in which a lower structure is formed, forming a phase-change material layer of a first state over the lower structure, transforming an upper region of the phase-change material layer of the first state into a phase-change material layer of a second state having an etch selectivity different from the phase-change material layer of the first state, removing the phase-change material layer of the second state, and forming an upper electrode over the phase-change material layer of the first state in which the phase-change material layer of the second state is removed.
US08859382B2 Methods of forming metal oxide and memory cells
Some embodiments include methods of forming memory cells. Metal oxide may be deposited over a first electrode, with the deposited metal oxide having a relatively low degree of crystallinity. The degree of crystallinity within the metal oxide may be increased after the deposition of the metal oxide. A dielectric material may be formed over the metal oxide, and a second electrode may be formed over the dielectric material. The degree of crystallinity may be increased with a thermal treatment. The thermal treatment may be conducted before, during, and/or after formation of the dielectric material.
US08859375B2 High voltage device and manufacturing method thereof
The present invention discloses a high voltage device and a manufacturing method thereof. The high voltage device is formed in a first conductive type substrate, wherein the substrate includes isolation regions defining a device region. The high voltage device includes: a drift region, located in the device region, doped with second conductive type impurities; a gate in the device region and on the surface of the substrate; and a second conductive type source and drain in the device region, at different sides of the gate respectively. From top view, the concentration of the second conductive type impurities of the drift region is distributed substantially periodically along horizontal and vertical directions.
US08859371B2 Method for manufacturing semiconductor device having dual gate dielectric layer
Methods for manufacturing a semiconductor device having a dual gate dielectric layer may include providing a substrate including first and second regions, forming a first gate dielectric layer having a first thickness on the substrate, forming an interlayer insulating layer including first and second trenches exposing the first gate dielectric layer in the first and second regions, forming a sacrificial layer on the interlayer insulating layer and bottoms of the first and second trenches, forming a sacrificial pattern exposing the first gate dielectric layer of the bottom of the first trench, removing the first gate dielectric layer of the bottom of the first trench, forming a second gate dielectric layer having a second thickness on the bottom of the first trench, removing the sacrificial pattern, and forming a gate electrode on each of the first and second gate dielectric layers.
US08859370B2 Method for forming impurity region of vertical transistor and method for fabricating vertical transistor using the same
A method for forming an impurity region of a vertical transistor includes forming an impurity ion junction region within a semiconductor substrate, and forming a trench by etching the semiconductor substrate in which the impurity ion junction region is formed. The etching process is performed to remove a portion of the impurity ion junction region, so that a remaining portion of the impurity ion junction region is exposed to a lower side wall of the trench to serve as a buried bit line junction region.
US08859366B2 Methods of fabricating silicon carbide devices having smooth channels
Methods of forming silicon carbide power devices are provided. An n− silicon carbide layer is provided on a silicon carbide substrate. A p-type silicon carbide well region is provided on the n− silicon carbide layer. A buried region of p+ silicon carbide is provided on the p-type silicon carbide well region. An n+ region of silicon carbide is provided on the buried region of p+ silicon carbide. A channel region of the power device is adjacent the buried region of p+ silicon carbide and the n+ region of silicon carbide. An n− region is provided on the channel region and a portion of the n− region is removed from the channel region so that a portion of the n− region remains on the channel region to provide a reduction in a surface roughness of the channel region.
US08859365B2 Semiconductor device and method for manufacturing same
According to one embodiment, a method for manufacturing a semiconductor device includes: forming a plurality of trenches; forming a gate insulating film; burying a gate electrode; burying an insulating member; projecting the insulating member; forming a base layer; forming a mask film; forming a first semiconductor layer; forming a carrier ejection layer; forming a first electrode; and forming a second electrode. The projecting includes projecting the insulating member from the upper surface of the semiconductor substrate by removing an upper layer portion of the semiconductor substrate. The mask film is formed so as to cover the projected insulating member. The forming the first semiconductor layer includes forming a first semiconductor layer of the first conductivity type in an upper layer portion of the base layer by doping the base layer with impurity, the upper layer portion having a lower surface below an upper end of the gate electrode.
US08859363B2 Semiconductor devices including vertical channel transistors and methods of fabricating the same
Methods of fabricating semiconductor devices may include forming first trenches in a substrate to define fin patterns and forming buried dielectric patterns filling lower regions of the first trenches. The first trenches extend in parallel. A gate dielectric layer is formed on upper inner sidewalls of the first trenches, and a gate conductive layer filling the first trenches is formed on the substrate including the gate dielectric layer. The gate conductive layer, the gate dielectric layer and the fin patterns are patterned to form second trenches crossing the first trenches and defining active pillars. Semiconductor devices may also be provided.
US08859353B2 Semiconductor device and fabrication method thereof
A p channel TFT of a driving circuit has a single drain structure and its n channel TFT, an LDD structure. A pixel TFT has the LDD structure. A pixel electrode disposed in a pixel unit is connected to the pixel TFT through a hole bored in at least a protective insulation film formed of an inorganic insulating material and formed above a gate electrode of the pixel TFT, and in an inter-layer insulation film disposed on the insulation film in close contact therewith. These process steps use 6 to 8 photo-masks.
US08859349B2 Multi-level charge storage transistors and associated methods
Methods of fabricating charge storage transistors are described, along with apparatus and systems that include them. In one such method, a pillar of epitaxial silicon is formed. At least first and second charge storage nodes (e.g., floating gates) are formed around the pillar of epitaxial silicon at different levels. A control gate is formed around each of the charge storage nodes. Additional embodiments are also described.
US08859346B2 Method for manufacturing array substrate with embedded photovoltaic cell
A method for manufacturing array substrate with embedded photovoltaic cell includes: providing a substrate; forming a buffer layer on the substrate; forming an amorphous silicon layer on the buffer layer; converting the amorphous silicon layer into a polysilicon layer; forming a pattern on the polysilicon layer; forming a first photoresist pattern on the polysilicon layer and injecting N+ ions; forming a gate insulation layer on the polysilicon layer; forming a second photoresist pattern on the gate insulation layer and injecting N− ions; forming a third photoresist pattern on the gate insulation layer and injecting P+ ions; forming a metal layer on the gate insulation layer so as to form a gate terminal; forming a hydrogenated insulation layer on the metal layer; forming a first ditch in the first insulation layer; and forming a second metal layer on the first insulation layer.
US08859345B2 Method for fabrication of III-nitride heterojunction semiconductor device
A III-nitride heterojunction power semiconductor device having a barrier layer that includes a region of reduced nitrogen content.
US08859344B2 Semiconductor memory
Manufacturing processes for phase change memory have suffered from the problem of chalcogenide material being susceptible to delamination, since this material exhibits low adhesion to high melting point metals and silicon oxide films. Furthermore, chalcogenide material has low thermal stability and hence tends to sublime during the manufacturing process of phase change memory. According to the present invention, conductive or insulative adhesive layers are formed over and under the chalcogenide material layer to enhance its delamination strength. Further, a protective film made up of a nitride film is formed on the sidewalls of the chalcogenide material layer to prevent sublimation of the chalcogenide material layer.
US08859340B2 Molded interposer package and method for fabricating the same
A method includes the operations performing a first anisotropic etching process to remove a portion of the metal sheet from a top surface of the metal sheet, thereby forming a plurality of first recesses in the metal sheet; mounting a carrier on the top surface of the metal sheet, covering the first recesses; performing a second anisotropic etching process to remove a portion of the metal sheet under the first recesses from the bottom surface of the metal sheet; filling a molding material from the bottom surface of the metal sheet, leaving the bottom surface of the metal sheet exposed; forming a passivation layer on the top surface of the metal sheet, having a plurality of openings therethrough; forming a plurality of first metal vias through the opening; and forming a solder mask layer on the passivation layer, leaving the first metal vias exposed.
US08859337B2 Thermal matching in semiconductor devices using heat distribution structures
Embodiments described herein provide a chip, comprising a first device on a substrate and a second device on the substrate. The chip further comprises a heat distribution structure in thermal proximity to the first device and the second device, wherein the heat distribution structure is thermally isolated and reduces a thermal gradient between the first device and the second device.
US08859335B2 Method and system for controlling chip inclination during flip-chip mounting
A method for alignment of a first substrate coupled to a second substrate includes determining an inclination angle for the first substrate or the second substrate due to warpage. The method includes determining a joint height difference based on the inclination angle and configuring a size for one or more bond pads based on the joint height difference.
US08859334B2 Electronic device manufacturing method and chip assembly
An electronic device manufacturing method includes a cutting step at which a wafer is cut to obtain chips before pattern formation and a polishing step at which cut surfaces of the obtained chips are subjected in one batch to barrel polishing. The method further includes an aligning step at which the polished chips are aligned so that front surfaces thereof face in an upward direction. The method further includes a bonding step at which the cut surfaces of the aligned chips are bonded together with an adhesive to thereby form a chip assembly. The method further includes a pattern forming step at which a circuit pattern is formed on each of the chips of the chip assembly and a melting step at which the adhesive on the chip assembly is melted to thereby separate the chip assembly into chips after pattern formation.
US08859330B2 Method for manufacturing semiconductor device
A semiconductor device including an oxide semiconductor, which has stable electric characteristics and high reliability, is provided. In a method for manufacturing a transistor including an oxide semiconductor film, an implantation step where rare gas ions are implanted to the oxide semiconductor film is performed, and the oxide semiconductor film to which rare gas ions are implanted is subjected to a heating step under reduced pressure, in a nitrogen atmosphere, or in a rare gas atmosphere, whereby hydrogen or water contained in the oxide semiconductor film to which rare gas ions are implanted is released; thus, the oxide semiconductor film is highly purified.
US08859329B2 Memory cells and methods of forming memory cells
Some embodiments include memory cells having programmable material between a pair of electrodes. The programmable material includes a material selected from the group consisting of a metal silicate with a ratio of metal to silicon within a range of from about 2 to about 6, and metal aluminate with a ratio of metal to aluminum within a range of from about 2 to about 6. Some embodiments include methods of forming memory cells. First electrode material is formed. Programmable material is formed over the first electrode material, with the programmable material including metal silicate and/or metal aluminate. Second electrode material is formed over the programmable material, and then an anneal is conducted at a temperature within a range of from about 300° C. to about 500° C. for a time of from about 1 minute to about 1 hour.
US08859325B2 Thin film deposition apparatus, method of manufacturing organic light-emitting display device by using the apparatus, and organic light-emitting display device manufactured by using the method
A thin film deposition apparatus, a method of manufacturing an organic light-emitting display device by using the thin film deposition apparatus, and an organic light-emitting display device manufactured by using the method. The thin film deposition apparatus includes: a deposition source that discharges a deposition material; a deposition source nozzle unit disposed at a side of the deposition source and including a plurality of deposition source nozzles arranged in a first direction; a patterning slit sheet disposed opposite to the deposition source nozzle unit and including a plurality of patterning slits having different lengths arranged in the first direction; and a barrier plate assembly disposed between the deposition source nozzle unit and the patterning slit sheet in the first direction, and including a plurality of barrier plates that partition a space between the deposition source nozzle unit and the patterning slit sheet into a plurality of sub-deposition spaces, wherein the thin film deposition apparatus is separated from the substrate by a predetermined distance, and the thin film deposition apparatus and the substrate are movable relative to each other.
US08859324B2 Methods of manufacturing solar cell devices
Embodiments of the present invention are directed to a process for making solar cells. Particularly, embodiments of the invention provide simultaneously co-firing (e.g., thermally processing) metal layers disposed both on a first and a second surface of a solar cell substrate to complete the metallization process in one step. By doing so, both the metal layers formed on the first and the second surfaces of the solar cell substrate are co-fired (e.g., simultaneously thermally processed), thereby eliminating manufacturing complexity, cycle time and cost to produce the solar cell device. Embodiments of the invention may also provide a method and solar cell structure that requires a reduced amount of a metallization paste on a rear surface of the substrate to form a rear surface contact structure and, thus, reduce the cost of the formed solar cell device.
US08859321B2 Mixed temperature deposition of thin film silicon tandem cells
Fabrication of a tandem photovoltaic device includes forming a bottom cell having an N-type layer, a P-type layer and a bottom intrinsic layer therebetween. A top cell is formed relative to the bottom cell. The top cell has an N-type layer, a P-type layer and a top intrinsic layer therebetween. The top intrinsic layer is formed of an undoped material deposited at a temperature that is different from the bottom intrinsic layer such that band gap energies for the top intrinsic layer and the bottom intrinsic layer are progressively lower for each cell.
US08859319B2 Methods of forming photo detectors
Methods of forming photo detectors are provided. The method includes providing a semiconductor layer on a substrate, forming a trench in the semiconductor layer, forming a first single crystalline layer and a second single crystalline layer using a selective single crystalline growth process in the trench, and patterning the first and second single crystalline layers and the semiconductor layer to form a first single crystalline pattern, a second single crystalline pattern and an optical waveguide.
US08859317B2 Gas sensor and manufacturing method thereof
A gas sensor manufacturing method comprises the following steps: providing a SOI substrate, including an oxide layer, a device layer, and a carrier, wherein the oxide layer is disposed between the device layer and the carrier; etching the device layer to form an integrated circuit region, an outer region, a trench and at least one conducting line; coating or imprinted a sensing material on the integrated circuit region; and etching the carrier and the oxide layer to form a cavity up to the gap so as to form a film structure which is suspended in the cavity by the cantilevered connecting arm.
US08859316B2 Schottky junction si nanowire field-effect bio-sensor/molecule detector
A Schottky junction silicon nanowire field-effect biosensor/molecule detector with a nanowire thickness of 10 nanometer or less and an aligned source/drain workfunction for increased sensitivity. The nanowire channel is coated with a surface treatment to which a molecule of interest absorbs, which modulates the conductivity of the channel between the Schottky junctions sufficiently to qualitatively and quantitatively measure the presence and amount of the molecule.
US08859314B2 Method of manufacturing semiconductor light emitting device
There is provided a method of manufacturing a semiconductor light emitting device, the method including: sequentially growing a first conductivity type semiconductor layer, an active layer, and a second conductivity type semiconductor layer on a semiconductor growth substrate to form a light emitting part; forming a support part on the second conductivity type semiconductor layer to be coupled to the light emitting part; separating the semiconductor growth substrate from the light emitting part; and applying an etching gas to the semiconductor growth substrate to remove a residue of the first conductivity type semiconductor layer from a surface of the semiconductor growth substrate.
US08859313B2 Method for manufacturing semiconductor light emitting element, semiconductor light emitting element, lamp, electronic device and mechanical apparatus
A method for manufacturing a semiconductor light emitting element (1) which includes a first step of forming a first n-type semiconductor layer (12c) on a substrate (11) and a second step of sequentially forming a regrowth layer (12d) of the first n-type semiconductor layer (12c), a second n-type semiconductor layer (12b), a light emitting layer (13), and a p-type semiconductor layer (14) on the first n-type semiconductor layer (12c). In the step of forming the second n-type semiconductor layer (12b), a step (1) of supplying Si less than that forming the regrowth layer (12d) as a dopant to form a first layer of the second n-type semiconductor layer and a step (2) of supplying the Si more than that in the step (1) to form a second layer of the second n-type semiconductor layer are performed in this order.
US08859307B2 Semiconductor device and method for manufacturing same
According to an embodiment, a method for manufacturing a semiconductor device includes a placement step and a bonding step. The placement step faces a semiconductor active portion toward a support substrate portion via a bonding portion disposed between the semiconductor active portion and the support substrate portion. The bonding portion includes a bonding layer and a light absorption layer, absorptance of the light absorption layer for laser light being higher than or equal to absorptance of the bonding layer for the laser light. The bonding step bonds the semiconductor active portion and the support substrate portion by irradiating the light absorption layer with the laser light through the support substrate portion and melting the bonding layer by thermal conduction from the light absorption layer heated by the laser light.
US08859303B2 IR emitter and NDIR sensor
An IR source in the form of a micro-hotplate device including a CMOS metal layer made of at least one layer of embedded on a dielectric membrane supported by a silicon substrate. The device is formed in a CMOS process followed by a back etching step. The IR source also can be in the form of an array of small membranes —closely packed as a result of the use of the deep reactive ion etching technique and having better mechanical stability due to the small size of each membrane while maintaining the same total IR emission level. SOI technology can be used to allow high ambient temperature and allow the integration of a temperature sensor, preferably in the form of a diode or a bipolar transistor right below the IR source.
US08859302B2 Structure and method for adjusting threshold voltage of the array of transistors
A semiconductor device including a charge storage element present in a buried dielectric layer of the substrate on which the semiconductor device is formed. Charge injection may be used to introduce charge to the charge storage element of the buried dielectric layer that is present within the substrate. The charge that is injected to the charge storage element may be used to adjust the threshold voltage (Vt) of each of the semiconductor devices within an array of semiconductor devices that are present on the substrate.
US08859300B2 On chip inductor with frequency dependent inductance
A set of metal line structures including a signal transmission metal line and a capacitively-grounded inductively-signal-coupled metal line is embedded in a dielectric material layer. A capacitor is serially connected between the capacitively-grounded inductively-signal-coupled metal line and a local electrical ground, which may be on the input side or on the output side. The set of metal line structures and the capacitor collective provide a frequency dependent inductor. The Q factor of the frequency dependent inductor has multiple peaks that enable the operation of the frequency dependent inductor at multiple frequencies. Multiple capacitively-grounded inductively-signal-coupled metal lines may be provided in the frequency-dependent inductor, each of which is connected to the local electrical ground through a capacitor. By selecting different capacitance values for the capacitors, multiple values of the Q-factor may be obtained in the frequency dependent inductor at different signal frequencies.
US08859298B2 Nanobeads covered with plasminogen as a direct support for cyclic amplification of the prion protein PrPSC
The present invention relates to an in vitro method for detecting a pathogenic conformational isomer of the prion protein in a sample, said method comprising a preliminary step for capturing the pathogenic conformational isomer by putting the sample into contact with nanobeads covered with a ligand of the pathogenic conformational isomer, and then applying a cyclic amplification of the misfolded prion protein directly on the solid support having captured the pathogenic conformational isomer, and detecting the presence of the pathogenic conformational isomer. The invention also relates to a kit for applying this method and to a method for decontaminating a biological sample.
US08859297B2 Detection of conductive polymer-labeled analytes
The disclosure relates to the detection of analytes (e.g., biological pathogens such as bacteria or viruses) using a conductive polymer label. The disclosed detection system utilizing the conductive polymer label generally involves the formation of an analyte conjugate between the target analyte and a conductive polymer moiety conjugated to the target analyte. The conductive polymer portion of the analyte conjugate is electrically activated to form an electrically activated analyte conjugate having an increased electrical conductivity relative to the analyte conjugate as originally formed. The electrically activated analyte conjugate can then be detected by any suitable means, such as by conductimetric or electrochemical detection.
US08859295B2 System and method to measure dissociation constants
A system and method for determining the dissociation constant for a particular ligand is disclosed. In accordance with certain embodiments, the method creates a chemical denaturation curve of a protein in the absence of the ligand. A particular point is selected from this curve, such as the point at which 90% of the protein is unfolded. The molarity of chemical denaturant is determined for this selected point. A one point test is then performed for the protein with a predetermined concentration of the particular ligand. The fraction of protein which is unfolded at this point is then used to determine the dissociation constant for the ligand. This constant is used to quickly determine whether a particular ligard is well suited to be considered a potential drug candidate against that protein target.
US08859294B2 Method for binding a protein consisting of protein A or consisting of at least one domain of the A to E domains of the protein A to the substrate
The object of the present invention is to provide a method for immobilizing the SpA protein on the surface of a substrate with high density without causing dimerization.The following method solves the object. That is, the method for binding a protein to a surface of a substrate, comprising steps (A) to (B): step (A) of preparing said protein to the surface, step (B) of supplying said protein to the surface, wherein said protein consists of a Protein A or at least one domain of A to E of said Protein A, and said protein comprises C-terminal modified amino acid sequence represented by SEQ ID:1(SFNRSEC).
US08859289B2 Method and laboratory system for handling sample tubes and an image analyzing unit
A method and laboratory system for handling sample tubes and an image analyzing unit are disclosed. An incoming primary rack (PR) containing sample tubes (S) is transferred to an image analyzing unit (310). Geometry parameters of at least one sample tube contained in the primary rack are determined by means of image analyzing and compared with predetermined geometry criteria. If the sample tube's geometry fulfils the criteria, the sample tube is categorized as system conform and removed from the primary rack with a gripper for further processing; otherwise it is categorized as non-system conform and entered into error processing.
US08859283B2 Cryopreservation of biological cells and tissues
The method involves placing an oocyte cell in a cell holder (1), securing the cell holder in a treatment station, applying a treatment solution to the cell by washing the cell with the solution, and rapidly cooling the cell holder and cell to a predetermined cryopreservation temperature for cryopreservation of the cell. The cell is cooled at a high rate sufficient to permit vitrification of the cell and any surrounding treatment solution to occur. The cell is then maintained at or below a predetermined storage temperature for storage. The method allows multiple cells to be treated simultaneously each secured within a respective cell holder.
US08859279B2 Cell detachment method
A cell detachment method for detaching only a desired cell from a plurality of cells cultured on a substrate under predetermined culture environment conditions by using a scanning probe microscope having a probe, comprising: observing the plural cells; specifying the cell to be detached; moving the probe onto the specified cell; and pressing the prove against the specified cell with a predetermined force so as to detach the cell from the substrate.
US08859278B2 Fully human hybridoma fusion partner cell lines
Certain aspects of the present invention are directed to new fully human fusion partner cell lines called human Karyochi cells, and to methods for making them. Human Karyochi cells are then fused with human antibody-secreting lymphoid cells to make fully human hybridomas called Karyochi-based hybridomas, which likewise secrete fully human monoclonal antibodies. Human Karyochi cells are made by isolating a donor nucleus that is substantially free of cytoplasm from either a first malignant B-lymphocyte cell line or a normal B-lymphocyte, and transferring the donor nucleus into the cytoplasm of a recipient cell from a second T- or B-lymphoid cell line. With time the nuclei synchronize and fuse to form the chimeric Karyochi fusion partner cell line. Nuclear transfer can be accomplished using intra-cytosolic nucleus injection or by impact-induced nucleus administration.
US08859272B2 Micro-device and methods for disrupting cells
A micro-device for disrupting cells includes a first chamber in which the cells are disrupted, a second chamber which is pressurized and depressurized, a flexible membrane which separates the first chamber and the second chamber and is vibrated by pressuring and depressurizing the second chamber, and a micro-unit confined in the first chamber, where the micro-unit disrupts the cells in the first chamber
US08859268B2 Quantitative multiplex detection of pathogen biomarkers
The present invention addresses the simultaneous detection and quantitative measurement of multiple biomolecules, e.g., pathogen biomarkers through either a sandwich assay approach or a lipid insertion approach. The invention can further employ a multichannel, structure with multi-sensor elements per channel.
US08859264B2 Phantom for the experimental in-vitro validation of radiation procedures under the influence of motion, taking into account the biological effective dose
A phantom device for in-vitro validation of radiation procedures under motion influence in consideration of an effective biological dose includes a phantom having a first biological detector with a first biological sample. The first biological sample includes a plurality of culturing and irradiation elements. Each of the culturing and irradiation elements are provided with a respective biological sub-sample so that the first biological detector is configured as a spatially resolving biological detector. A first motion device is configured to move the first biological detector so as to simulate a motion of a target volume.
US08859263B2 Method and apparatus for holding cells
The present invention pertains to an apparatus for holding cells. The apparatus comprises a mechanism for incubating cells having a dynamically controlled environment in which the cells are grown, which are maintained in a desired condition and in which cells can be examined while the environment is dynamically controlled and maintained in the desired condition. The apparatus also comprises a mechanism for determining the state of the cells. The determining mechanism is in communication with the incubating mechanism. The present invention pertains to a method for holding cells. The method comprises the steps of incubating the cells in a dynamically controlled environment which is maintained in a desired condition and in which the cells can be examined while the environment is dynamically controlled and maintained in the desired condition. Additionally, there is the step of determining the state of the cells.
US08859262B2 Photobioreactor systems positioned on bodies of water
Certain embodiments and aspects of the present invention relate to a photobioreactor including photobioreactor units through which a liquid medium stream and a gas stream flow. The photobioreactor units are floated on a body of water such as a pond or a lake. The liquid medium comprises at least one species of phototrophic organism therein. Certain methods of using the photobioreactor system as part of fuel generation system and/or a gas-treatment process or system at least partially remove certain undesirable pollutants from a gas stream. In certain embodiments, the photobioreactor units are formed of flexible, deformable material and are configured to provide a substantially constant thickness of liquid medium. In certain embodiments, a barrier between the photobioreactor unit and the body of water upon which the unit is floated facilitates thermal communication between the liquid medium and the body of water.
US08859260B2 Expression cassette for lactase dehydrogenase, transformed yeast and method of producing lactic acid
A gene expressing cassette codes lactate dehydrogenase that is needed for prevention of deterioration in lactic acid yield and lactic acid production rate in continuous culture with simultaneous filtration of a yeast strain having a lactic acid-producing ability, which achieves high optical purity, high lactic acid yield and high lactic acid production rate simultaneously, a yeast strain having the cassette and a method of producing lactic acid by culturing the yeast strain. The lactate dehydrogenase-expressing cassette is a lactate dehydrogenase-expressing cassette, comprising a gene coding lactate dehydrogenase connected to a site downstream of a promoter, the promoter being a promoter of a gene showing a gene expression amount larger by 5 times or more than the average relative expression amount of all genes after 50 hours from start of culture in continuous culture with simultaneous filtration of a yeast strain having a lactic acid-producing ability.
US08859258B2 Composite oil displacement agent containing a microorganism for oil displacement and a preparation method thereof
A composite oil displacement agent contains the following main components: 20 to 40% of microorganism, 6 to 30% of surfactant, 5 to 10% of macromolecular modifier, 1 to 5% of viscosity reducer, 1 to 5% of additive and the balance of water. The preparation method thereof comprises the steps of: in proportion by weight, adding the microorganism, the surfactant, the macromolecular modifier, the viscosity reducer, the additive, and the water to a reactor provided with a stirring device, and stirring the components for 1.5 to 2 h at room temperature to obtain the finished product.
US08859257B2 Vaccinia virus mutants containing the major genomic deletions of MVA
The present invention provides modified vaccinia virus (VACV) genomes as well as vectors, especially viral vectors comprising the same. The present invention further provides modified vaccinia viruses. The present invention further provides methods for determining the effect of mutations in VACV with regard to competence for replication in certain cell types. The present invention further provides methods of preparing modified vaccinia viruses.
US08859255B2 Alpha-amylase variants
The invention relates to a variant of a parent Termamyl-like alpha-amylase, which variant exhibits altered properties, in particular reduced capability of cleaving a substrate close to the branching point, and improved substrate specificity and/or improved specific activity relative to the parent alpha-amylase.
US08859253B2 Cellobiohydrolase variants and polynucleotides encoding same
The present invention relates to variants of a parent cellobiohydrolase II. The present invention also relates to polynucleotides encoding the variants; nucleic acid constructs, vectors, and host cells comprising the polynucleotides; and methods of using the variants.
US08859251B2 Oligoadenylate synthetase (OAS)
The invention describes novel pharmaceutical compositions for the treatment of virus infections and cancer. The pharmaceutical compositions include mutant oligoadenylate synthetases (OAS) that have either enhanced cell permeability, reduced oxidative potential, improved antiviral activity, improved enzymatic activity, or absent enzymatic activity. The pharmaceutical compositions have improved drug properties and retain or have enhanced antiviral activity relative to their native forms. The pharmaceutical compositions further include chemically modified oligoadenylate synthetases, such chemical modifications being designed to increase serum stability and reduce immunogenicity in vivo. Such chemical modifications further increase drug stability and manufacturability in vitro. Compositions composed of more than ninety novel modifications are described. Also described are antibodies to polypeptides of the invention.
US08859250B2 Crystal structure of glutaminyl cyclase
Novel crystal structures of human and murine glutaminyl cyclase (QC, EC 2.3.2.5), methods of preparing the crystals, as well as the use of said crystal structures for identifying inhibitors of human and murine glutaminyl cyclase.
US08859249B2 Process of treatment for oxidizing an acidic solution containing an iodide ion and an iron (II) ion
A method for producing an iron (III) ion from the acidic solution containing an iodide ion and an iron (II) ion efficiently and stably is provided. The method including performing the following steps (a)-(b), repeatedly and continuously: (a) a step wherein the iron (II) ion in the acidic solution containing the iodide ion and the iron (II) ion is oxidized into iron (III) ion in a reactor using a microbes immobilizing carrier to which iron oxidizing microbes attached; (b) a step wherein sedimentation of the solution obtained in the step (a) is performed in a sedimentation tank to obtain the solution containing the iron (III) ion and concurrently the sediment of the microbes immobilizing carrier to which the iron oxidizing microbes have attached is recovered and then reintroduced into the reactor in the step (a).
US08859247B2 Process for cell-free production of chemicals
An enzymatic process is described for the production of chemicals from carbon sources. In particular, according to one aspect, a process for the production of a target organic compound from a carbon source by a cell-free enzyme system is disclosed.
US08859241B2 Process for production of L-amino acid
Provided is a novel process for producing an L-amino acid using a microorganism belonging to the genus Escherichia. According to the present invention, a process for producing an L-amino acid comprising; culturing a microorganism in which an activity of the protein of any of the following [1]-[3] is increased compared with that of the parent strain in a medium, producing and accumulating the L-amino acid in the medium, and recovering the L-amino acid from the medium: [1] a protein comprising the amino acid sequence shown in SEQ ID NO: 2 [2] a protein consisting of an amino acid sequence in which one or more amino acids are deleted, substituted or added in the amino acid sequence shown in SEQ ID NO: 2, and having YeiG activity [3] a protein consisting of an amino acid sequence having 80% or more homology to the amino acid sequence shown in SEQ ID NO: 2, and having YeiG activity.
US08859240B2 Dengue and West Nile viruses proteins and genes coding the foregoing, and their use in vaccinal, therapeutic and diagnostic applications
The present invention relates to the development of viral vectors expressing different immunogens from the West Nile Encephalitis Virus (WNV) or the Dengue virus which are able to induce protective humoral and cellular immune responses against WNV or Dengue virus infections. More specifically, the present invention relates to three (3) antigens from WNV (the secreted envelope glycoprotein (E), the heterodimer glycoproteins (pre-M-E) and the NSI protein) and from Dengue virus (the secreted envelope glycoprotein (e), the heterodimer glycoproteins (pre-m-e) and the nsl protein) and their use in vaccinal, therapeutic and diagnostic applications.
US08859239B2 Methods for small RNA sequencing
Next generation sequencing technologies are becoming a preferred method for sequencing nucleic acids and profiling miRNAs. Experimental results disclosed herein show that the most common platform for preparing nucleic acids such as miRNAs for sequencing introduces serious biases. Provided herein are compositions and methods for improved sequencing and miRNA profiling using a set of customized ligation adaptors.
US08859235B2 Methods in cell cultures, and related inventions, employing certain additives
A method for the manufacture of products by biotechnological methods in bacterial cell culture is disclosed as well as products obtained, the use of certain additives to the media used in the manufacture of said products in bacterial cell culture media, and the use of said additives in reducing the detrimental effects of radicals in the manufacture of the products, as well as aspects related to these invention embodiments. The manufacturing process or method comprises adding one or more radical scavenging and/or antioxidative additive preferably selected from the group consisting of sterically hindered nitroxyls, sterically hindered hydroxylamines, sterically hindered hydroxylamine salt compounds, sterically hindered amino compounds and sterically hindered N-hydrocarbyloxyamines, benzofuranone compounds, as obligatory component(s) to the medium used during biosynthesis.
US08859229B2 Transient transfection with RNA
A method of mRNA production for use in transfection is provided, that involves in vitro transcription of PCR generated templates. This RNA can efficiently transfect different kinds of cells. This approach results in increased efficiency (fidelity and productivity) of mRNA synthesis and is less time consuming because it does not require cloning, and also consequently eliminates the unwanted errors and effects related to RNA made on DNA templates obtained with cloning techniques. The results of transfection of RNAs demonstrate that RNA transfection can be very effective in cells that are exceedingly difficult to transfect efficiently with DNA constructs. The method can be used to deliver genes into cells not- or only poorly transfectable for DNA, in vitro and in vivo.
US08859226B2 Measurement method for viable cell count, and culture medium
There are provided a method of identifying the longum species alone, such as Bifidobacterium longum subsp. longum alone, and measuring the viable cell count thereof, amongst the bacterial cells to be tested which include a microorganism belonging to the genus Bifidobacterium by using a culture medium that contains L-arabinose as a sole sugar source; and also a culture medium which is useful as a selective medium for the above measurement method and which is also easy to prepare.
US08859224B2 Microinjection device and microinjection method
A fluorescence-intensity detecting unit detects fluorescence intensity by injecting a first solution containing a fluorescent reagent into a second solution that does not form an interface with the first solution through an injecting member. A calculating unit calculates the injection amount of the first solution from the fluorescence intensity based on a correlation between fluorescence intensities and injection amounts measured in advance. A computing unit obtains a correlation between an injection amount, pressure and pressurizing time based on the calculated injection amount. An adjusting unit adjusts the amount of the first solution to be injected into the endoplasmic reticulum by controlling pressure and pressurizing time based on the obtained correlation.
US08859223B1 Compositions and methods for imaging beta-secretase activity in living cells and organisms
Molecular probes are provided for use in fluorescence microscopy procedures for monitoring beta-secretase enzyme (BACE) activity in living cells and organisms. The probes may be useful for monitoring Alzheimer's Disease-associated BACE in living cells. By fluorescing when hydrolyzed by BACE, the probes can allow for real-time spatial and temporal assessment of enzymatic activity without the need for mutated cell lines or antibodies. The molecular probes may also be used to screen libraries of potential BACE inhibitors or evaluate how external stimuli affect BACE activity.
US08859222B2 Methods and compositions for detection of microbial contaminants in peritoneal dialysis solutions
Methods and compositions for detection of microbial contaminants in peritoneal dialysis solutions are provided. A novel cause of aseptic peritonitis is provided—aseptic peritonitis associated with gram positive microbial contamination of a dialysis solution. Peptidoglycan is a major component of a gram positive bacterial cell wall and thus can serve as a marker for gram positive bacteria. In this regard, testing for peptidoglycans can be utilized to effectively prevent peritonitis in patients that use the peritoneal dialysis solutions, such as peritoneal dialysis solutions that contain a glucose polymer including an icodextrin and the like.
US08859215B2 Cell binding assay
The present invention relates to a fluorescent cell binding assay combining pre-labeling and Western blotting. Intact cells are incubated with pre-labelled binders preferably followed by SDS PAGE (sodium dodecylsulphate polyacrylamide gel) separation and Western blotting. More closely, the invention relates to a cell binding assay in which the degree or amount of binding of one or more cell interacting protein or protein component to the cell surface is measured with the ability to correlate the degree of cell binding to the sample load/total number of cells.
US08859212B2 Method of extracting food component, food inspection method and food inspection kit
Provided is a technique of extracting a component in a food from the food by using a reducing agent that is inexpensive and has a mild reducing action. A component in a food is extracted by mixing the food with an extractant containing a sulfite. In addition, the resultant food extract is brought into contact with a specific antibody that specifically recognizes a substance included in a specified ingredient of interest for inspection, to thereby inspect the presence or absence and/or the amount of a specified ingredient in a food by utilizing an immunological measurement method. Further provided is a food inspection kit for inspection of the presence or absence and/or the amount of a specified ingredient in a food, including: (1) an extractant and a sulfite to be added to the extractant, or an extractant including a sulfite added; and (2) an antibody that specifically recognizes a substance included in a specified ingredient of interest for inspection.
US08859202B2 Breast cancer biomarker signatures for invasiveness and prognosis
MicroRNA profiles transition from normal breast to ductal carcinoma in situ and transition to invasive ductal carcinoma (IDC) and methods of use thereof are described. Methods of diagnosis and prognosis using microRNA signatures to differentiate invasive from in situ carcinoma are described. Also described is the use of microRNA expression for predicting overall survival and time to metastasis.
US08859201B2 Methods for sequencing a biomolecule by detecting relative positions of hybridized probes
A sequencing method is presented in which a biomolecule is hybridized with a specially chosen pool of different probes of known sequence which can be electrically distinguished. The different probe types are tagged such that they can be distinguished from each other in a Hybridization Assisted Nanopore Sequencing (HANS) detection system, and their relative positions on the biomolecule can be determined as the biomolecule passes through a pore or channel. The methods eliminate, resolve, or greatly reduce ambiguities encountered in previous sequencing methods.
US08859197B2 Sperm-specific cation channel, CATSPER3, and uses therefor
Nucleic acid and protein sequences relating to a cation channel which is sperm-specific (CatSper3) are disclosed. The CatSper3 protein is shown to be specifically expressed in sperm. Nucleic acids, vectors, transformed cells, transgenic animals, polypeptides, and antibodies relating to the CatSper3 gene and protein are disclosed. Also provided are methods of in vitro fertilization and contraception, methods of identifying modulators of CatSper3 activity, methods of genotyping subjects with respect to CatSper3, and methods of diagnosing and treating CatSper3-mediated disorders, including infertility. Related business methods are also disclosed.
US08859194B2 Polymer compound, and resist-protecting film composition including same for a liquid immersion exposure process
A polymer compound and a resist protective film composition for an immersion lithography process including the same.
US08859193B2 Method of applying patterned metallization to block filter resonators
An embodiment of the present invention provides a method of applying patterned metallization to a ceramic block comprising applying a photodefinable ink to said ceramic block; drying said ink; exposing said photodefinable ink to UV radiation through a predefined mask according to the thickness of the film to form a pattern; developing said pattern in a developer solution thereby forming a patterned ceramic block; and rinsing, drying and firing said patterned ceramic block.
US08859189B2 Patterning process
The invention provides a patterning process, comprising at least a step of forming a silicon-containing film on a body to be processed by using a composition for the silicon-containing film, a step of forming, on the silicon-containing film, a photoresist film by using a resist composition, a step of exposing to the photoresist film after heat treatment thereof, and a step of forming a negative pattern by dissolving an unexposed area of the photoresist film by using a developer of an organic solvent; wherein a composition giving the silicon-containing film whose pure-water contact angle in the part corresponding to the exposed area of the photoresist film becomes in the range of 35° or more to lower than 70° after exposure is used as the composition. There can be optimum patterning process as a patterning process of a negative resist pattern to be formed by adopting organic solvent-based development.
US08859187B2 Method of forming resist pattern and negative resist composition
A novel method of forming a resist pattern in which thickness loss from the resist pattern is reduced, and a negative resist composition that can be used in this method of forming a resist pattern. The method of forming a resist pattern includes: forming a first resist film by applying a first resist composition to a support, forming a first resist pattern by selectively exposing the first resist film through a first mask pattern and then developing the first resist film, forming a second resist film by applying a negative resist composition containing an ether-based organic solvent (S″) having no hydroxyl groups onto the support having the first resist pattern formed thereon, and forming a resist pattern by selectively exposing the second resist film through a second mask pattern and then developing the second resist film.
US08859185B2 Resist underlayer film-forming composition
A resist underlayer film-forming composition includes a polymer including a repeating unit shown by a formula (1), and having a polystyrene-reduced weight average molecular weight of 3000 to 10,000, and a solvent. Each of R3 to R8 individually represent a group shown by the following formula (2) or the like. R1 represents a single bond or the like. R2 represents a hydrogen atom or the like.
US08859182B2 Resist composition and method for producing resist pattern
A resist composition contains (A) a resin having a structural unit represented by the formula (I), (B) an acid generator and (D) a compound represented by the formula (II), wherein R1, ring X1, R3, R4, m, and n are defined in the specification.
US08859181B2 Chemically amplified negative resist composition and patterning process
A chemically amplified negative resist composition is provided comprising (A) an alkali-soluble base polymer, (B) an acid generator, and (C) a nitrogen-containing compound, the base polymer (A) turning alkali insoluble under the catalysis of acid. A polymer having a fluorinated carboxylic acid onium salt on a side chain is included as the base polymer. Processing the negative resist composition by a lithography process may form a resist pattern with advantages including uniform low diffusion of acid, improved LER, and reduced substrate poisoning.
US08859173B2 Electrophotographic photoreceptor, process cartridge, image forming apparatus, cured film, and organic electroluminescent device
An electrophotographic photoreceptor is disclosed, in which an outermost surface layer of the electrophotographic photoreceptor is made of a cured film of a composition including a compound represented by the following Formula (M1) and a charge transporting material having a chain polymerizable functional group:
US08859161B2 Proton conductive inorganic thin film, method of forming the same, and fuel cell including the proton conductive inorganic thin film
A proton-conductive inorganic thin film including an inorganic proton conductor, a method of forming the proton-conductive inorganic thin film, and a fuel cell including the proton-conductive inorganic thin film as an electrolyte membrane.
US08859158B2 System and method for controlling operation of fuel cell hybrid system by switching to battery power in response to idle stop condition
The present invention provides a hybrid fuel cell system that is configured to determine if an idle stop condition has been satisfied during a normal operation mode of the hybrid fuel cell system, cut off air supply to a fuel cell to stop power generation of the fuel cell and reduce a voltage which the fuel cell outputs in response to determining that the idle stop condition has been satisfied. The voltage of a bidirectional converter, connected between a battery and a bus terminal is reduced and the output of the fuel cell is controlled, based on a first predetermined value and maintained at that first predetermined value. Subsequently, the battery is charged via the output current of the fuel cell generated by maintaining the reduced voltage of the bidirectional converter.
US08859157B2 Fuel cell system and its control method
A fuel cell system includes; a fuel cell which generates electricity by using a fuel gas and an oxidant gas as reaction gases; current control means which controls current of a fuel cell; voltage control means which controls voltage of the fuel cell; and heat value control means which calculates a heat value required by the fuel cell system and decides a target current value of the current control means and a target voltage value of the voltage control means so as to generate the calculated necessary heat amount, thereby controlling the heat value. Thus, it is possible to supply a heat required for the fuel cell system without increasing the size of the fuel cell system.
US08859156B2 Solid oxide fuel cell
To provide a solid oxide fuel cell capable of extending the time period over which a minimum rated output power can be maintained while restraining the advance of fuel cell module degradation.The present invention is a solid oxide fuel cell (1), having a fuel cell module (2), a fuel supply device (38), an oxidant gas supply device (45), and a controller (110); wherein the controller is furnished with a degradation determining circuit for determining degradation (110a) and a fuel correction circuit for correcting operating condition (110b); in which the fuel correction circuit executes a correction to reduce rated output power so that the fuel supply amount is reduced when a determination is made that the fuel cell module has degraded, and when degradation of the fuel cell module advances and predetermined correction switching condition is satisfied, the fuel correction circuit corrects the fuel supply amount supplied to the fuel cell module so as to maintain the reduced rated output power.
US08859153B1 Thermal conditioning fluids for an underwater cryogenic storage vessel
Technologies are described herein for conditioning fluids stored in an underwater cryogenic storage vessel designed for use in a fuel system of an underwater vehicle. According to one aspect of the disclosure, a fuel system includes a fuel cell and a storage vessel, which stores a first fluid that is supplied to the fuel cell and a second fluid that is produced by the fuel cell. The fuel system also includes a thermal conditioning module that receives the first fluid from the storage vessel and receives the second fluid from the fuel cell. The first fluid stored in the storage vessel is conditioned by absorbing heat from the second fluid, such that the fuel cell receives the conditioned first fluid. The second fluid received from the fuel cell is in gaseous state and is converted to a liquid. The liquid second fluid is stored in the storage vessel.
US08859143B2 Partially and fully surface-enabled metal ion-exchanging energy storage devices
A surface-enabled, metal ion-exchanging battery device comprising a cathode, an anode, a porous separator, and a metal ion-containing electrolyte, wherein the metal ion is selected from (A) non-Li alkali metals; (B) alkaline-earth metals; (C) transition metals; (D) other metals such as aluminum (Al); or (E) a combination thereof; and wherein at least one of the electrodes contains therein a metal ion source prior to the first charge or discharge cycle of the device and at least the cathode comprises a functional material or nano-structured material having a metal ion-capturing functional group or metal ion-storing surface in direct contact with said electrolyte, and wherein the operation of the battery device does not involve the introduction of oxygen from outside the device and does not involve the formation of a metal oxide, metal sulfide, metal selenide, metal telluride, metal hydroxide, or metal-halogen compound. This energy storage device has a power density significantly higher than that of a lithium-ion battery and an energy density dramatically higher than that of a supercapacitor.
US08859142B2 Non-aqueous electrolyte secondary battery
A non-aqueous electrolyte secondary battery comprising electrodes including a positive electrode and a negative electrode, a separator positioned between the electrodes, and a non-aqueous electrolyte, wherein the electrodes have a collector carrying an active substance material, and the collector of at least one of the positive electrode and the negative electrode is a three-dimensional structure formed of a resin fiber covered with a metal film.
US08859140B2 Electrode for molten salt battery, molten salt battery, and method for producing electrode
An electrode for a molten salt battery includes a current collector connectable to an electrode terminal of the molten salt battery and an active material. The current collector has an internal space in which small spaces are mutually coupled. The internal space of the current collector is filled with the active material.
US08859137B2 Fuel cell system
A fuel cell system includes a fuel cell module, a combustor, a fuel gas supply apparatus, an oxygen-containing gas supply apparatus, a water supply apparatus, a power converter, a control device, and a casing containing the fuel cell module, the combustor, the fuel gas supply apparatus, the oxygen-containing gas supply apparatus, the water supply apparatus, the power converter, and the control device. The casing includes a casing body having an opening in the front face and a slide door that is installed onto the casing body. When the slide door slides horizontally, the opening is opened/closed. The power converter and the control device are attached onto the slide door at upper and lower positions.
US08859134B2 Battery connector
A battery connector includes: a plurality of terminals, each of which is to be connected to each electrode of a plurality of batteries; and a case which contains the plurality of terminals therein. The case includes a terminal fixing part in which the plurality of terminals are fixed, and an insulating cover which is supported to be displaced to a closing position at which an open face of the terminal fixing part is covered by the insulating cover. A wire guide is formed in an outer surface of the insulating cover in the closing position.
US08859133B2 Repeating frame battery with compression joining of cell tabs to welded connection terminals
A repeating frame assembly for a battery pack includes a first cooling frame member having a first electrically conductive connection terminal adjacent a first end of the first cooling frame member. The connection terminal includes a top leg forming at least a portion of the first surface of the first cooling frame member and a bottom leg forming at least a portion of the second surface of the first cooling frame member. A first electrically conductive tab of a first battery cell is attached to the top leg of the first electrically conductive connection terminal. A second battery cell may be contained within a second cooling frame member or a first spacer frame member having a second electrically conductive connection terminal adjacent a first end thereof for providing a compression joint having a low resistance electrical connection to the second tab of the first battery cell.
US08859132B2 Variable volume containment for energy storage devices
A stacked energy storage device (ESD) has at least two cell segments arranged in a stack. Each cell segment may have a first electrode unit having a first active material electrode, a second electrode unit having a second active material electrode, and an electrolyte layer between the active material electrodes. Variable volume containment may be used to control the inter-electrode spacing within each cell segment. In some embodiments, one or more dynamic flexible gaskets may be included in each cell segment to seal the electrolyte within the cell segment and to deform in preferred directions. In some embodiments, hard stops may set the inter-electrode spacing of the ESD.
US08859131B2 Battery module and battery pack including the same
A battery module and battery pack, the battery module including a pair of end plates facing each other; a plurality of battery units arranged in a first direction between the end plates; a first side plate extending along a first side of the plurality of battery units, the first side plate being coupled to the end plates; a second side plate extending along a second side of the plurality of battery units, the second side plate being coupled to the end plates and being disposed opposite to the first side plate; a first coupling member, the first coupling member coupling the end plates to the first side plate; and a second coupling member, the second coupling member coupling the end plates to the second side plate, wherein the first coupling member and the second coupling member are disposed in asymmetrical positions with respect to a central line of the end plates.
US08859127B2 Rack housing assembly and energy storage apparatus having the same
An energy storage apparatus and a rack housing assembly having the same are disclosed. In one embodiment, the energy storage apparatus includes i) a plurality of battery trays arranged substantially parallel to each other so as to form at least one row and ii) a first duct located at a first side of the battery trays, wherein a plurality of first openings are formed in the first duct. The apparatus may further include i) a second duct located at a second side of the battery trays, wherein a plurality of second openings are formed in the second duct, and wherein the first and second sides are different from each other, ii) an air intake configured to forcibly intake air into the first duct and iii) an air exhaust configured to forcibly exhaust air from the second duct to the outside of the energy storage apparatus.
US08859120B2 Lithium reservoir system and method for rechargeable lithium ion batteries
A lithium-ion battery cell includes at least two working electrodes, each including an active material, an inert material, an electrolyte and a current collector, a first separator region arranged between the at least two working electrodes to separate the at least two working electrodes so that none of the working electrodes are electronically connected within the cell, an auxiliary electrode including a lithium reservoir, and a second separator region arranged between the auxiliary electrode and the at least two working electrodes to separate the auxiliary electrode from the working electrodes so that none of the working electrodes is electronically connected to the auxiliary electrode within the cell.
US08859116B2 Multi-layer coating
A multi-layer coating for protection of metals and alloys against oxidation at high temperatures is provided. The invention utilizes a multi-layer ceramic coating on metals or alloys for increased oxidation-resistance, comprising at least two layers, wherein the first layer (3) and the second layer (4) both comprise an oxide, and wherein the first layer (3) has a tracer diffusion coefficient for cations Mm+, where M is the scale forming element of the alloy, and the second layer (4) has a tracer diffusion coefficient for oxygen ions O2− satisfying the following formula: ∫ ln ⁢ ⁢ p ⁡ ( O 2 ) in ln ⁢ ⁢ p ⁡ ( O 2 ) ex ⁢ ( D O + m 2 ⁢ D M ) ⁢ ⁢ ⅆ ln ⁢ ⁢ p ⁡ ( O 2 ) < 5 · 10 - 13 ⁢ ⁢ cm 2 / s wherein p(O2)in, p(O2)ex, DM and DO are as defined herein. The coating may be used in high temperature devices, particularly for coating interconnect materials in solid oxide electrolytic devices, including solid oxide fuel cells (SOFCs) and solid oxide electrolysis cells (SOECs).
US08859114B2 Coating for improved wear resistance
In one aspect, coated cutting tools are described herein which, in some embodiments, can demonstrate improved wear resistance in one or more cutting applications. In some embodiments, a coated cutting tool described herein comprises a substrate and a coating adhered to the substrate, the coating comprising an inner layer deposited by physical vapor deposition and an outer deposited by physical vapor deposition over the inner layer.
US08859113B2 Carbazole derivatives and organic light-emitting diode device using the same
The present invention relates to novel carbazole derivatives and an organic light-emitting diode device using the same. These carbazole derivatives can simultaneously or singly be used as a hole transporting layer, a host or guest of an emitting layer or an electron transporting layer of an organic light-emitting diode device.
US08859111B2 Materials for organic electroluminescent devices
The present invention relates to 4,4′-substituted spirobifluorenes which are suitable, owing to excellent properties, as functional materials in organic electroluminescent devices. In addition, the present invention relates to a process for the preparation of 4,4′-substituted spirobifluorenes and to the use of these compounds in organic electroluminescent devices.
US08859104B2 Transparent conducting oxides
The invention provides a transparent conducting film which comprises a compound of formula (I): Zn1-x[M]xO1-y[X]y(I) wherein: x is greater than 0 and less than or equal to 0.25; y is from 0 to 0.1; [X] is at least one dopant element which is a halogen; and [M] is: (a) a dopant element which is selected from: a group 14 element other than carbon; a lanthanide element which has an oxidation state of +4; and a transition metal which has an oxidation state of +4 and which is other than Ti or Zr; or (b) a combination of two or more different dopant elements, at least one of which is selected from: a group 14 element other than carbon; a lanthanide element which has an oxidation state of +4; and a transition metal which has an oxidation state of +4 and which is other than Ti or Zr. The invention further provides coatings comprising the films of the invention, processes for producing such films and coatings, and various uses of the films and coatings.
US08859102B2 Barrier structure and method for making
The disclosure is directed to a barrier structure including a fluoropolymer layer, a polymeric layer, and an adhesive layer. The barrier structure has a chemical permeation breakthrough detection time greater than about one hour for hazardous chemicals as measured by ASTM F739. The disclosure is further directed to a method of forming the aforementioned barrier structure. The barrier material is designed to be suitable for construction of shelters, clothing, containers and other articles requiring barrier properties.
US08859082B2 Recording medium
A recording medium includes a film that has a recording surface on which an image is recorded. The film includes a fold line that is provided in advance at a position where the film is folded when the film is processed into a folder.
US08859079B2 Glass having excellent resistance against surface damages and method for the production thereof
A glass having excellent resistance against surface damages is provided. The glass includes a content of alkaline earth oxides of at least 0.3% by weight and of P2O5 of 0.1 to 4% by weight; the glass has at least one surface that has precipitations with a mean size of 1 to 20 μm. A method is further provided and includes melting a glass batch, yielding a glass melt, and casting the glass melt onto a float bath. The glass melt is maintained on the float bath at a temperature of above 1000° C. for at least 5 minutes, and yields glass. The glass has a content of alkaline earth oxides of at least 0.3% by weight and of P2O5 of 0.1 to 4% by weight, and the glass has at least one surface that has precipitations with a mean size of 1 to 20 μm.
US08859075B2 Silicon carbide ceramic and honeycomb structure
A silicon carbide ceramic is provided which has a small amount of resistivity change due to changes in temperature and which is capable of generating heat by current application. The silicon carbide ceramic contains silicon carbide crystals having 0.1 to 25 mass % of 4H—SiC silicon carbide crystals and 50 to 99.9 mass % of 6H—SiC silicon carbide crystals, preferably having a nitrogen content of 0.01 mass % or less, more preferably containing two or more kinds of silicon carbide particles containing silicon carbide crystals and silicon for binding the silicon carbide particles to each other and having a silicon content of from 10 to 40 mass %.
US08859072B2 Cut-out sintered ceramic sheet and method of manufacturing the same
A cut-out sintered ceramic sheet including a side surface, the entire surface of which is a fracture surface having reliefs, wherein a plastic resin film is adhered onto upper and lower surfaces of the cut-out sintered ceramic sheet.
US08859070B2 Elastic membrane
An elastic member for use in a substrate holding apparatus includes an elastic member and a first reinforcing member. The first reinforcing member has a higher rigidity than the elastic membrane and reinforces substantially an entire area of the contact portion of the elastic membrane. The contact portion of the elastic member has a contact portion for contact with the substrate. The first peripheral wall portion of the elastic membrane is coupled to a peripheral end of the contact portion and extends upwardly. The second peripheral wall portion of the elastic member defines a first chamber on an outer side thereof and a second chamber on an inner side thereof. The first reinforcing member is embedded in substantially the entire area of the contact portion of the elastic membrane.
US08859067B2 Pearlescent container
A pearlescent container comprising about 86% to about 99.99% of a thermoplastic material having a Total Luminous Transmittance value of at least about 80%, about 0.01% to about 5% of a siloxane fluid having a viscosity of no greater than about 1,000,000 cst, wherein said thermoplastic material and said siloxane fluid are immiscible, forms a lamellar structure, and have a Refractive Index difference of at least about 0.1.
US08859066B2 Coating composition, method of preparation thereof and substrate coated therewith
A coating composition, a process for producing it and substrate coated therewith are described. The composition comprises a multimodal ethylene polymer, which contains from 80 to 99.8% by weight of ethylene repeating units and from 0.2 to 20% by weight of C3-C20 α-olefin repeating units, and is a blend of at least a first and a second ethylene polymer prepared by polymerization in the presence of a single site catalyst system.The blend has a density of 0.915-0.955 g/cm3, a melt flow rate, MFR2, of 0.028-1.5 g/10 min., a molecular weight distribution, Mw/Mn, of 3-10, and a CTL 5.0 MPa-value according to ISO 6259 of at least 500 hrs.
US08859062B2 Multilayer propylene resin sheet and heat-treatable packaging material using same
The invention provides a multilayer sheet and a heat-treatable packaging material which have excellent flexibility, transparency, impact resistance, heat resistance, heat-sealability and cleanliness, which are endowed with a good formability without readily incurring drawbacks such as external defects and thickness fluctuations when subjected to multilayer formation, and which, even at a reduced thickness, have an excellent sheet substrate strength decrease-inhibiting effect.The multilayer sheet is a multilayer propylene resin sheet composed of at least two layers of an inner layer (1) and an outer layer (2), wherein the inner layer (1) is made of a resin composition (X) containing from 60 to 90 wt % of (A) a propylene resin composition which includes from 30 to 70 wt % of (A1) a specific propylene-α-olefin random copolymer component and from 70 to 30 wt % of (A2) a propylene-ethylene random copolymer component, from 40 to 10 wt % of (B) an ethylene-α-olefin copolymer, and from 1 to 25 wt % of (C) a propylene resin, and the outer layer (2) is made of a specific propylene resin composition Y. The heat-treatable packaging material can be obtained from the multilayer propylene resin sheet.
US08859054B2 System and method for depositing material in a substrate
One embodiment of the present invention is a unique method for depositing materials in a substrate. Another embodiment is a unique system for depositing materials in a substrate. Other embodiments include apparatuses, systems, devices, hardware, methods, and combinations for depositing materials within a substrate. Further embodiments, forms, features, aspects, benefits, and advantages of the present application will become apparent from the description and figures provided herewith.
US08859051B2 Composition for ferroelectric thin film formation, method for forming ferroelectric thin film and ferroelectric thin film formed by the method thereof
Disclosed is a composition for ferroelectric thin film formation which is used in the formation of a ferroelectric thin film of one material selected from the group consisting of PLZT, PZT, and PT. The composition for ferroelectric thin film formation is a liquid composition for the formation of a thin film of a mixed composite metal oxide formed of a mixture of a composite metal oxide (A) represented by general formula (1): (PbxLay)(ZrzTi(1-z))O3 [wherein 0.9
US08859048B2 Selective placement of carbon nanotubes through functionalization
The present invention provides a method for selectively placing carbon nanotubes on a substrate surface by using functionalized carbon nanotubes having an organic compound that is covalently bonded to such carbon nanotubes. The organic compound comprises at least two functional groups, the first of which is capable of forming covalent bonds with carbon nanotubes, and the second of which is capable of selectively bonding metal oxides. Such functionalized carbon nanotubes are contacted with a substrate surface that has at least one portion containing a metal oxide. The second functional group of the organic compound selectively bonds to the metal oxide, so as to selectively place the functionalized carbon nanotubes on the at least one portion of the substrate surface that comprises the metal oxide.
US08859046B2 Substrate processing apparatus, control method adopted in substrate processing apparatus and program
A substrate processing apparatus according to the present invention comprises a plurality of processing chambers, discharge systems each provided in conjunction with one of the processing chambers and a common discharge system connected with the discharge systems of at least two processing chambers among the discharge systems provided in conjunction with the individual processing chambers. The common discharge allows a switch-over between a scrubbing common discharge system that discharges discharge gas from each processing chamber after scrubbing the discharge gas at a scrubbing means and a non-scrubbing common discharge system that directly discharges the discharge gas from the discharge system of the processing chamber without scrubbing at the scrubbing means. In this substrate processing apparatus, switch-over control is executed to select either the scrubbing common discharge system of the non-scrubbing common discharge system in correspondence to the type of processing executed in the processing chamber.
US08859042B2 Methods for heating with lamps
Embodiments of the invention generally relate to methods for chemical vapor deposition (CVD) processes. In one embodiment, a method for heating a substrate or a substrate susceptor within a vapor deposition reactor system includes exposing a lower surface of a substrate susceptor, such as a wafer carrier, to energy emitted from a heating lamp assembly, and heating the substrate susceptor to a predetermined temperature. The heating lamp assembly generally contains a lamp housing disposed on an upper surface of a support base and contains at least one lamp holder, a plurality of lamps extending from the lamp holder, and a reflector disposed on the upper surface of the support base, next to the lamp holder, and below the lamps. The plurality of lamps may have split filament lamps and/or non-split filament lamps for heating inner and outer portions of the substrate susceptor.
US08859038B2 Method for monitoring corrosion protection in power plant
Provided is a method for monitoring corrosion in a power plant, including: forming a film with a composition of M1FeO3 (M1 is a trivalent or tetravalent metal) or M2Fe2O4 (M2 is a divalent metal) on the inner wall surface of an apparatus of the power plant; and maintaining the film stably by controlling the amount of introduction of oxygen into the apparatus commensurate with a temperature in the apparatus.
US08859031B2 Efficient path coating on labcoat IPMP coating system
A method of coating a medical prosthesis includes identifying coating points on the surface of the medical prosthesis and determining a coating pathway along which an applicator travels while coating the medical prosthesis. In some embodiments, the coating pathway minimizes the rotational movement of the medical prosthesis during the coating process. In other embodiments, the coating pathway minimizes the amount of time needed for the coating process.
US08859028B2 Coated food particle and method for making a swirl
The present invention comprises an edible swirl imparting carrier for flavor or color or flavor and color. The edible carrier comprises a coating effective for imparting a color in a viscous or visco-elastic matrix when moved in the matrix. The present invention also includes a method for imparting a swirl of color in a viscous or visco-elastic medium.
US08859024B2 Separatable shell for receiving candy coating and storing toy
A container has first and second sections with an opening into hollow interiors. They mate together to form a sealed enclosure, and to form a ridge having a cross-sectionally curved outer surface. An appendage is connected to the ridge including an aperture for receiving a hook. A coating of edible material is on the outer surface of at least a portion of at least one of the first and second sections. An external flange extends around the periphery of the opening of the first section, an internal flange extends around the periphery of the opening of the second section, wherein the internal flange is sized to contact and fit inside the external flange during mating. An aperture passes through the internal flange, wherein mating the first and second sections causes the external flange to cover and seal the internal flange aperture.
US08859022B2 Antihypertensive agents
The present invention relates to an antihypertensive agent including a boysenberry seed extract as an active ingredient. According to the invention, there can be provided an effective and highly safe antihypertensive agent having antihypertensive effect so that the agent can contribute to the prevention and amelioration of hypertension and having very little risk of side effects even in continuous intake, and a method for producing the antihypertensive agent at low cost and efficiently.
US08859020B2 Treatment of alzheimer's with a curcuminoid mixture and essential oil of turmeric having 45% Ar-turmerone
Disclosure provides a formulation of curcuminoid with essential oil of turmeric to enhance the bioavailability of curcumin and to augment the biological activity of curcumin, wherein curcumin is the main constituent of curcuminoid and wherein Ar-turmerone is the main constituent of the essential oil of turmeric. An application of curcuminoid with essential oil of turmeric to enhance the bioavailability of curcumin for oral supplementation against a variety of diseases and method of doing the same is provided.
US08859017B2 Botanical extracts from oil palm vegetation liquor for cosmeceutical applications
A cosmeceutical composition comprising phenolic compounds, fruit acids and sugars, extracted from the vegetation liquor of the palm oil milling process has been suggested. This composition is rich in antioxidants, and significantly improves skin health, including preventing aging of the skin.
US08859011B2 Calcium compositions
Compositions comprising calcium carbonate and processes for making such compositions are provided. The invention provides a granulation comprising about 95% to about 99% by weight calcium carbonate, about 0.5% to about 5% by weight of a binder and about 0.03% to about 3% by weight of a porosity increasing agent. A pharmaceutical or nutritional composition prepared from such a granulation comprises about 90% to about 99% by weight calcium carbonate, about 0.03% to about 3% by weight of a porosity increasing agent, and about 1% to about 10% by weight of other excipients. The composition provides a smaller tablet than conventional calcium carbonate compositions, for improved ease of swallowing.
US08859009B2 Method of fixing antibacterial agent and article obtained by the method
An object of the present invention is to provide a method of fixing an antibacterial agent, by which method it is possible to impart articles of a wide range of materials with excellent antibacterial property and good persistence of antibacterial activity. Specifically, the method of fixing an antibacterial agent, comprises the steps of: subjecting a surface of an article to a surface treatment of providing the surface with oxygen-containing functional groups; and then subjecting the article to a treatment using an antibacterial agent composition including a silicon-containing compound (a) represented by general formula (1) below. wherein R1 represents a hydrocarbon group having 6 or more carbon atoms, R2 and R3 represent lower hydrocarbon groups, respectively, which hydrocarbon groups may be the same or different from each other, R4 represents a divalent lower hydrocarbon group, R5, R6 and R7 represent lower alkyl groups or lower alkoxy groups, respectively, which may be the same or different from each other, and X represents a halogen ion or an organic carbonyloxy ion, or alternatively, first treating the article by using the antibacterial agent composition; and then subjecting the article to a 1-10 GHz microwave irradiation treatment in a state where the antibacterial agent composition remains on the surface of the article.
US08859007B2 Oxygenated demineralized bone matrix for bone growth
An improved composition for inducing bone growth is provided that is a mixture of DBM and a perfluorocarbon oxygen carrier. Injection/implantation of a composition of DBM and a perfluorocarbon results in enhancement of bone formation.
US08859006B2 Semen cassiae soft capsule for reducing fat and losing weight and preparation method thereof
A Semen Cassiae soft capsule for lowering blood lipids and losing weight and the preparation method thereof. The content of the soft capsule consist of the following components by weight part: 10-60 parts of ethanol soluble extract powder of Semen Cassiae, 2-10 parts of aqueous soluble extract powder of Radix Glycyrrhizae, 10-30 parts of evening primrose oil, 5-20 parts of sea buckthorn seed oil and 2-10 parts of beeswax. The preparation method includes the following steps: preparing all the components respectively; dissolving the ethanol soluble extract powder of Semen Cassiae in ethanol, adding 50% of the total weight of beeswax, heating in a water bath at 75 degrees Celsius to obtain a liquid mixture of Semen Cassiae and beeswax; heating the remainder beeswax with evening primrose oil, adding the liquid mixture of Semen Cassiae and beeswax while continuously stirring, adding aqueous soluble extract powder of Radix Glycyrrhizae, cooling the mixture by circulation water, adding sea buckthorn seed oil and continuously stirring to obtain the content for soft capsules, encapsulating soft capsules by conventional method to obtain the Semen Cassiae soft capsule.
US08859005B2 Enteric delivery of functional ingredients suitable for hot comestible applications
A microencapsulated enteric matrix composition and method for manufacture are provided. The microencapsulated enteric composition includes enteric material, such as sodium caseinate and soy protein, and a functional ingredient contained therein in a core. Further, the composition includes a first coating including zein and the second, outer coating including ethylcellulose. The microencapsulated enteric composition may be suitable for use in hot comestibles.
US08859001B2 Fenoldopam formulations and pro-drug derivatives
Formulations of fenoldopam are disclosed for repeated administration or continued slow release administration, over prolonged periods of time or targeted slow and regulated delivery. The formulations include those formulations that increase the bioavailability of fenoldopam after oral intake, particularly lipid based nano dispersions and pronanodispersions and surfactant rich formulations. This may be accomplished by entrapment in nanoparticles or liposomal formulations or conjugation to a polymer or small molecule via a soft bond.
US08858997B2 Formulations and methods for lyophilization and lyophilates provided thereby
The present invention provides compositions, methods for lyophilizing compounds and making pharmaceutical compositions, and kits providing solutions and lyophilized formulations of compounds. The compositions, methods, and kits are particularly useful in pharmaceutical applications involving therapeutic agents that have low solubility at low pH and medium pH values. Certain embodiments provide methods for lyophilizing compounds in liquid solutions, which include the steps of: a) preparing aqueous solutions of a compound of interest in the absence of buffer; b) adjusting the pH to high values of pH in order to increase the solubility of the compound of interest; and c) freeze-drying the solution to provide a lyophilized solid composition. Aqueous solutions including buffer are also disclosed. Lyophilized formulations, including micronized and non-micronized powders, are provided.
US08858992B2 High drug load mesalazine sachet
The present invention is directed to a high drug formulation having desirable properties in terms of ease of manufacture and visual appearance as well as a sachet for the formulation.
US08858987B2 Wound dressing for the controlled release of therapeutic agents
A wound dressing material for controlled activation of a wound healing therapeutic compound in the presence of a protease enzyme in a wound fluid, the material comprising: a medically acceptable polymer; a wound healing therapeutic agent; an inhibitor of the protease enzyme; and a linker group which is cleavable by the protease enzyme, wherein the activities of both the wound healing therapeutic agent and the inhibitor are increased by contacting the wound dressing material with a wound fluid containing the protease enzyme. For example, the enzyme may be a matrix metalloproteinase, the therapeutic agent may be a reactive oxygen scavenger, and the inhibitor may be a tissue inhibitor of metalloproteinase (TIMP).
US08858986B2 Biocompatible hydrophilic compositions
Durable hydrophilic compositions comprising aliphatic polyester, an anionic surfactant, and in some embodiments, a carrier.
US08858985B2 Films comprising a liquid-absorbant inner layer, an antimicrobial material and an impermeable outer layer
Films comprising a liquid-absorbent layer with an adsorbed antimicrobial material and an impermeable layer are provided. The films can be suitable for preparation of tubular casings and shrinkbags such as casings for foodstuffs. Also disclosed are foodstuffs processed in the tubular casing comprising the antimicrobial material.
US08858982B2 Apparatus and methods for preventing or treating failure of hemodialysis vascular access and other vascular grafts
This invention is a prosthetic device generally placed on the outside surface of the vessel or graft which then elutes antiproliferative drugs or agents from a drug-eluting matrix material. Methods of perivascular antiproliferative drug administration also are disclosed.
US08858978B2 Heat cured gel and method of making
A method of curing and corresponding resulting non-polymeric cross-linked gel are provided. The cross-linked gel can be combined with a medical device structure. The cross-linked gel can provide anti-adhesion characteristics, in addition to improved healing and anti-inflammatory response. The cross-linked gel is generally formed of a naturally occurring oil, or an oil composition formed in part of a naturally occurring oil, that is at least partially cured forming a cross-linked gel derived from at least one fatty acid compound. In addition, the oil composition can include a therapeutic agent component, such as a drug or other bioactive agent. The curing method can vary the application of heat in both temperature and duration to achieve a desired amount of cross-linking forming the gel.
US08858971B2 Epidermal cooling
In one aspect, an epidermal coolant dispensable by an aerosol container includes a phase change material that changes phase between about 28-degrees and 40-degrees Celsius. The coolant also includes a solvent in which the phase change material is dissolved and a surfactant. The coolant may further include a propellant to express the product from the aerosol container. In another aspect, an epidermal coolant includes a porous material and a phase change material retained in the porous material. The phase change material has a melting point between about 0-degrees Celsius and about 65-degrees Celsius and is retained in the porous material when the phase change material is in either the solid or liquid phase.
US08858968B2 Use of tyrosine-arginine dipeptide and niacinamide as substance P antagonist
Use of the combination of the tyrosine-arginine dipeptide or derivatives thereof and of niacinamide as a substance P antagonist for treating red blotches on the skin, skin oedema and sensitive skin. Use of this combination for the preparation of a composition for use in treating disorders associated with an excess synthesis and/or release of substance P.
US08858965B2 Micelle encapsulation of a combination of therapeutic agents
The invention provides active agents, such as paclitaxel, rapamycin, or 17-DMAG, encapsulated by safe poly(ethylene glycol)-block-poly(lactic acid) (“PEG-b-PLA”) micelles. The compositions provide effective solubilization of drug combinations, such as paclitaxel, rapamycin, and 17-DMAG, as well as others described herein. A significant advantage of PEG-b-PLA as a carrier is that it is less toxic than Cremophor® EL or DMSO, which are used in currently known compositions. Additionally, PEG-b-PLA micelles are easier to handle than DMSO and they do not possess a foul odor, which is a problem with formulations currently in clinical trials. Accordingly, the invention provides stable and biocompatible drug formulations that improve bioavailability without causing toxicity. It was also found that larger doses of individual drugs in micelle formulations can be administered compared to non-micelle formulations.
US08858964B2 Anti-bacterial applications of poly-N-acetylglucosamine nanofibers
Described herein are compositions comprising shortened fibers of poly-N-acetylglucosamine and/or a derivative thereof (“sNAG nanofibers”) and anti-bacterial applications of such compositions. The sNAG nanofibers may be formulated into compositions for the prevention and/or treatment of bacterial infections and diseases associated with such infections. Regimens employing such compositions are also described.
US08858963B1 Tamper resistant composition comprising hydrocodone and acetaminophen for rapid onset and extended duration of analgesia
The present disclosure provides an extended release pharmaceutical composition comprising hydrocodone and acetaminophen that provides a rapid onset of analgesia, and reduced levels of acetaminophen near the end of the dosing interval. Also provided are methods for reducing the risk of acetaminophen-induced hepatic damage in a subject being treated with an acetaminophen containing composition, as well as methods for treating pain in a subject in need thereof.
US08858961B2 Compositions containing alpha-2-adrenergic agonist components
Compositions useful for improving effectiveness of alpha-2-adrenergic agonist components include carrier components, alpha-2-adrenergic agonist components, solubility enhancing components which aid in solubilizing the alpha-2-adrenergic agonist components. In one embodiment, the alpha-2-adrenergic agonist components include alpha-2-adrenergic agonists. In another embodiment, the solubility enhancing components include carboxymethylcellulose.
US08858960B2 Method of producing a pharmaceutical product
A pharmaceutical and pharmaceutical-like product is provided. The product provides a plurality of components having active agents that are delivered in a single delivery entity or vehicle. The product allows for selective control of the release rates of each of the active agents while still being delivered in a single product.
US08858957B2 GAS57 mutant antigens and GAS57 antibodies
The invention provides mutants of GAS57 (Spy0416) which are unable to cleave IL-8 and similar substrates but which still maintain the ability to induce protection against S. pyogenes. The invention also provides antibodies which specifically bind to GAS57 and which inhibit its ability to cleave IL-8 and similar substrates. The mutants are useful, inter alia, in vaccine compositions to induce protection against S. pyogenes. The antibodies are useful, e.g., as therapeutics for treating S. pyogenes infections.
US08858951B2 Compositions for eliciting an immune response
The invention is directed to the use of (i) a first antigen corresponding to a target antigen of interest, together with (ii) a second antigen, corresponding to a modified form of the target antigen, whose rate of intracellular proteolytic degradation is increased, enhanced or otherwise elevated relative to the first antigen, in compositions and methods for inducing both humoral and cellular immunity in an individual. The ability to provide compositions, which are capable of inducing both host-protective antibody and cell-mediated immune responses, facilitates the generation of immunogenic compositions capable of combating, inter alia, conditions that have long latency periods and, therefore, benefit from the dual approach of prophylaxis and therapy in one delivery.
US08858950B2 Delivery of pharmaceutical agents via the human insulin receptor
A humanized murine antibody is provided that binds to the human insulin receptor (HIR). The humanized murine antibody is suitable for use as a Trojan horse to deliver pharmaceutical agents to human organs and tissue that express the HIR. The humanized murine antibody is especially well suited for delivering neuropharmaceutical agents from the blood stream to the brain across the blood brain barrier (BBB). The humanized murine antibody may be genetically fused to the pharmaceutical agent or it may be linked to the pharmaceutical agent using an avidin-biotin conjugation system.
US08858946B2 Method for inhibiting HIV-1 replication utilizing anti-GBV-C E2 antibodies
GB virus C (GBV-C or hepatitis G virus) is a flavivirus that frequently leads to chronic viremia in humans. The invention provides compositions and methods involving an anti-GBV-C antibody or other GBV-C binding agent, or a GBV-C antigen, for inhibiting and treating HIV infections.
US08858944B2 Treatment drug for autoimmune diseases and allergic diseases
The present invention provides an agent for the prophylaxis or therapy of autoimmune diseases or allergic diseases, which contains an anti-Embigin antibody, particularly an anti-Embigin antibody showing cytotoxicity or a cytotoxicity inducing activity, an agent for the prophylaxis or therapy of diseases involving Th17 cell, and a cytotoxic agent to Th17 cell. In addition, an agent for detection of Th17 cell, which contains an anti-Embigin antibody, a convenient detection method of Th17 cell, which uses the agent, a method of efficiently delivering a drug and the like in a Th17 cell selective manner, which uses an anti-Embigin antibody, and a drug delivery system to Th17 cell are provided.
US08858943B2 Antigen binding proteins
The present invention relates to methods of treating diseases or disorders affecting the eye or optic nerve characterized by elevated β-amyloid levels or β-amyloid deposits, particularly age related macular degeneration and glaucoma type diseases and β-amyloid dependent cataract formation, with antigen binding proteins that bind β-amyloid peptide and in particular human β-amyloid peptide.
US08858942B2 Antibodies directed to ERBB2
The present invention relates to antibodies including human antibodies and antigen-binding portions thereof that specifically bind to ErbB2, preferably human ErbB2. In another embodiment, the antibodies or antigen-binding portions thereof inhibit ErbB2. The invention also relates to antibodies that are chimeric, bispecific, derivatized, single chain antibodies or portions of fusion proteins. The invention also relates to isolated heavy and light chain immunoglobulins or portions thereof derived from human anti-ErbB2 antibodies and nucleic acid molecules encoding such immunoglobulins. The present invention also relates to methods of using the antibodies and compositions for diagnosis and treatment. The invention also provides gene therapy methods using nucleic acid molecules encoding the heavy and/or light immunoglobulin molecules that comprise the human anti-ErbB2 antibodies. The invention also relates to transgenic animals or plants comprising nucleic acid molecules of the present invention.
US08858936B2 Compositions with hematopoietic and immune activity
The present invention provides methods of using Bv8 and EG-VEGF polypeptides and nucleic acids to promote hematopoiesis. Also provided herein are methods of screening for modulators of Bv8 and EG-VEGF activity. Furthermore, methods of treatment using Bv8 and EG-VEGF polypeptides or Bv8 and EG-VEGF antagonists are provided.
US08858935B2 Compositions and methods for increasing the stability of antibodies
The invention encompasses pharmaceutical compositions comprising an antibody and methods of formulating antibodies. The heavy and/or a light chain variable region of the antibody may have certain characteristics. In some embodiments, the antibody may comprise an N-glycan site in a heavy and/or light chain variable region. The compositions may comprise a buffering agent and, optionally, a sugar and/or a salt.
US08858931B2 Polynucleotides encoding MHC class I-restricted hTERT epitopes, analogues thereof or polyepitopes
This invention relates to the field of anticancer therapy, and to the identification of immunogenic peptides derived from the human telomerase reverse transcriptase (hTERT). The present invention relates to polynucleotides encoding hTERT epitopes restricted to MHC class I molecule, analogs thereof and polyepitopes containing such epitopes and/or analogs. Are also included in the present invention, vector and cell comprising such polynucleotides. The present invention also concerns composition comprising hTERT polypeptides, corresponding polynucleotides, vectors and cells, for use in the treatment and/or prevention of cancer.
US08858928B2 Gene therapy vectors for adrenoleukodystrophy and adrenomyeloneuropathy
The present invention provides compositions comprising retroviral vectors, transduced cells, and methods of using the same for gene therapy. In particular, the present invention relates to lentiviral vectors and cells transduced with those vectors to provide gene therapy to subjects having an adrenoleukodystrophy and/or adrenomyeloneuropathy.
US08858924B2 Compositions and methods for treatment of hemorrhage
Methods of treating hemorrhage are provided, comprising diagnosing one or more hemorrhaging or potentially hemorrhaging vessels in a patient and administering to the patient a therapeutically effective amount of a composition comprising a vessel closing compound at a concentration between about 0.1% and about 45%. The vessel closing compound may comprise a polymer with hydrophilic properties, such as polyethylene glycol (PEG). The composition may also comprise one or more active agent such as a blood flow modifier with a potential to form ionic bonds with the vessel closing agent.
US08858921B2 Composition containing a water-miscible liquid and a water-soluble particle, method of production and use thereof
The invention relates to a water-soluble composition comprising a water miscible liquid and water-soluble particles, the water-soluble composition being essentially free of water. The composition can be used e.g. as dental composition, cleaning agent, polishing agent, tongue surface cleaning agent or peeling agent.
US08858918B2 Chewing gum and confectionery compositions with encapsulated stain removing agent compositions, and methods of making and using the same
A composition in the form of a chewing gum composition or a confectionery composition containing an encapsulated stain removing agent selected from anionic and non-ionic surfactants and methods of preparing and using the same to remove stains from dental material including teeth.
US08858917B2 Methods for limiting spread of pulmonary infections
Formulations have been developed for pulmonary delivery to treat or reduce the infectivity of diseases such as vital infections, especially tuberculosis, SARS, influenza and respiratory synticial virus in humans and hoof and mouth disease in animals. Formulations for pulmonary administration include a material that significantly alters physical properties such as surface tension and surface elasticity of lung mucus lining fluid, which may be a surfactant and, optionally, a carrier. The formulation may be administered as a powder where the particles consist basically of the material altering surface tension. The carrier may be a solution, such as an alcohol, although an aqueous solution may be utilized, or a material mixed with the material altering surface tension to form particles. These may include proteins such as albumin or polysaccharides such as dextran, which also has surface active properties, or polymers such as polyethylene oxide (PEO) or biodegradable synthetic polymers which can be used to encapsulate or deliver the materials to be delivered. Drugs, especially antivirals or antibiotics, may optionally be included with the formulation. These may be administered with or incorporated into the formulation.
US08858915B2 Therapeutic or prophylactic agent, detection method and detection agent for metabolic syndrome, and method for screening of candidate compound for therapeutic agent for metabolic syndrome
The object is to provide: a therapeutic or prophylactic agent for metabolic syndrome, which has improved stability in a living body; and others. The therapeutic or prophylactic agent for metabolic syndrome comprises, as an active ingredient, DNA that encodes receptor activity-modifying protein (RAMP) 2 and is selected from the items (a) to (d) below or a polypeptide encoded by the DNA: (a) DNA which has the nucleotide sequence depicted in SEQ ID NO:1; (b) DNA which has a nucleotide sequence capable of hybridizing with the nucleotide sequence depicted in SEQ ID NO:1 under stringent conditions; (c) DNA which has a nucleotide sequence encoding an amino acid sequence having the substitution, deletion and/or addition of one or more amino acid residues in the amino acid sequence depicted in SEQ ID NO:2; and (d) DNA which has a nucleotide sequence having a 90% or more homology with the nucleotide sequence depicted in SEQ ID NO:1.
US08858913B2 Multimeric peptidomimetic fibrosis specific dual-modality probes
The present invention describes dual-modality probes. In particular, the present invention discloses fibrosis specific multimeric small-molecule peptidomimetic dual-modality MRI and optical probes.
US08858912B2 Frozen compositions and methods for piercing a substrate
Certain embodiments disclosed herein relate to compositions, methods, devices, systems, and products regarding frozen particles. In certain embodiments, the frozen particles include materials at low temperatures. In certain embodiments, the frozen particles provide vehicles for delivery of particular agents. In certain embodiments, the frozen particles are administered to at least one biological tissue.
US08858911B2 Phosphodiesterase 1-targeting tracers and methods
Tracers targeting phosphodiesterase 1 for use in gamma radiation detection-based diagnostic techniques, particularly gamma-emitter labeled tracers for SPECT and positron emitter-labeled compositions for PET are disclosed. Radio-labeled multiple novel scaffolds as PDE1 inhibitors such as substituted pyrazolo-pyrimidin-4-one derivatives, biomarkers for phosphodiesterase 1 [PDE1) in vivo, methods for developing novel therapies for PDE1-implicated conditions such as pulmonary arterial hypertension (PAH), Central Nervous System (CNS) and Cardiovascular (CV) disorders, and methods of detection and treatment are also disclosed.
US08858909B2 Carbon nanotube and method for producing same
There is provided a high-purity carbon nanotube, which can be produced with simple purification by causing graphite to be hardly contained in crude soot obtained immediately after being synthesized by arc-discharge, and a method for producing the same. Soot containing carbon nanotubes produced by arc-discharge using an anode which contains amorphous carbon as a main component is heated at a temperature of not lower than 350° C. to be burned and oxidized, immersed in an acid, heated at a temperature, which is not lower than the heating temperature in the previous burning and oxidation and which is not lower than 500° C., to be burned and oxidized, and immersed in an acid again.
US08858907B2 Catalytic reduction of NOx with high activity catalysts with NH3 reductant
Methods and systems for selective catalytic reduction of NOx with an ammonia reductant and a zeolite catalyst loaded with at least two metals selected from the group of tungsten, cobalt, and vanadium. An exhaust stream including NOx and a reductant stream including ammonia are provided to a catalytic reactor having the metal loaded zeolite catalyst at suitable operating temperatures for NOx reduction of at least 90%.
US08858906B2 Process for removal of carbon dioxide from a gas
The invention provides a process for the removal of CO2 from a gas, the process comprising the steps of: (a) removing CO2 from the gas by contacting the gas with absorbing liquid in an absorber to obtain absorbing liquid enriched in CO2 and a purified gas; (b) heating absorbing liquid enriched in CO2 (c) contacting heated absorbing liquid enriched in CO2 with a stripping gas at elevated temperature in a regenerator to obtain regenerated absorbing liquid and a hot gas stream enriched in CO2 wherein at least part of the absorbing liquid enriched in CO2 is heated through external heat exchange with the hot gas stream enriched in CO2.
US08858904B2 Catalyzed soot filter
Described is a catalyzed soot filter wherein the inlet coating of the filter comprises an oxidation catalyst comprising platinum (Pt) and optionally palladium (Pd), wherein the outlet coating of the filter comprises an oxidation catalyst comprising Pd and optionally Pt, wherein the Pt concentration in the outlet coating is lower than the Pt concentration in the inlet coating and wherein the weight ratio of Pt:Pd in the outlet coating is in the range of from 0:1 to 2:1; and wherein the inlet coating and the outlet coating are present on the wall flow substrate at a coating loading ratio in the range of from 0.5 to 1.5, calculated as ratio of the loading of the inlet coating (in g/inch3 (g/(2.54 cm)3)):loading of the outlet coating (in g/inch3 (g/(2.54 cm)3)). Systems include such catalyzed soot filters, methods of diesel engine exhaust gas treatment and methods of manufacturing catalyzed soot filters are also described.
US08858901B2 Use of a KMgF3 compound for trapping metals in the form of fluorides and/or oxyfluorides in a gaseous or a liquid phase
The invention relates to the use of a compound of the formula KmgF3 to trap metals in the form of fluorides and/or of oxyfluorides in a gaseous or liquid phase. It also relates to a compound of the formula KMgF3 which has a surface area at least equal to 30 m2/g and at most equal to 150 m2/g and also to its methods of preparation. The invention notably finds application in the nuclear industry, in which it can advantageously be used to purify uranium hexafluoride (UF6) present in a gaseous or liquid stream, with regard to metal impurities which are also present in this stream.
US08858894B2 Reactor for producing polycrystalline silicon using the monosilane process
A reactor that produces polycrystalline silicon using a monosilane process includes a reactor base plate having a multiplicity of nozzles formed therein through which a silicon-containing gas flows, a plurality of filament rods mounted on the reactor base plate, and a gas outlet opening located at a selected distance from the nozzles to feed used monosilane to an enrichment and/or treatment stage, wherein the gas outlet opening is formed at a free end of an inner tube, the inner tube is conducted through the reactor base plate, and the inner tube has an outer wall and an inner wall and thus forms an intermediate space in which at least one cooling water circuit is conducted.
US08858889B2 Contaminate control device
A contaminate control device for filtering contaminates from a gas such as air is provided. The device includes a housing having a first inlet and a first outlet. An axial flow filter is fluidly coupled between the first inlet and the first outlet, the axial flow filter has a second inlet and a second outlet. A second filter disposed about the axial flow filter and is fluidly coupled between the first inlet and the first outlet, the second filter having a third inlet on an inner diameter and a third outlet disposed on an outer diameter. A flow restrictor is fluidly coupled between the second inlet and the first inlet.
US08858887B2 Integrated chemical indicator device
A chemical indicator device for use in detecting exposure to an oxidizing agent, such as hydrogen peroxide, comprising a substrate or support upon which is disposed a chemical indicator composition (ink) for detecting an oxidizing agent, such as hydrogen peroxide. The chemical indicator composition further comprises an indicator dye that achieves a distinct range of different color changes with clear transitions between colors, upon exposure to different doses of the oxidizing agent, thus allowing for both a qualitative and semi-quantitative assessment of exposure to the agent.
US08858886B1 Scanning system with interchangeable optical cartridges for fluorescence measurements
The fluorescence measurement system includes a host apparatus and a self-contained, multichannel optical cartridge. The host apparatus includes a well plate receptacle, and a stage having optical cartridge receptacles that are elongate along one axis of the well plate. The stage and the well plate receptacle are movable relative to one another in the direction of the other axis of the well plate. The optical cartridge engages with the optical cartridge receptacle and includes a linear array of optical assemblies each including an excitation light source, and an emission light detector to generate an intensity signal. The optical cartridge also includes, a memory to store calibration information for each optical assembly. The host apparatus additionally includes a processor to correct the intensity signal from each optical assembly of the optical cartridge using the calibration information received from the optical cartridge for the optical assembly.
US08858885B2 Pixel-type biological analysis device, biosensor, and fabrication processes thereof
The disclosure relates to a pixel-type biological analysis device comprising a photosensitive layer, a capture mixture for the capture of targeted proteins, the capture mixture being placed on an external surface of the photosensitive layer and comprising a protein probe grafted to a hydrogel, collection means for collecting photoelectrons in the photosensitive layer, and reading and treatment means of an electrical quantity supplied by the collection means, for the supply of a characteristic value of a luminous intensity detected by the photosensitive layer.
US08858882B2 Automatic analysis device
There is provided a data processing method that reduces influences of air bubbles and dirt while maintaining changes in light amounts. Two scattering light photoreceivers are disposed in the forward direction. A photoreceiver 33a closer to the optical axis is taken to be a main angle photoreceiver, and a photoreceiver 33b further from the optical axis is taken to be a sub-angle photoreceiver. Noise is estimated based on the reaction process data of the sub-angle photoreceiver, and noise is reduced by subtracting the estimated noise from the reaction process data of the main angle photoreceiver.
US08858875B2 Nickel based alloy material
A Ni based alloy material consists of by mass percent, C≦0.03%, Si: 0.01 to 0.5%, Mn: 0.01 to 1.0%, P≦0.03%, S≦0.01%, Cr: not less than 20% to less than 30%, Ni: more than 40% to not more than 50%, Cu: more than 2.0% to not more than 5.0%, Mo: 4.0 to 10%, Al: 0.005 to 0.5%, W: 0.1 to 10%, N: more than 0.10% to not more than 0.35%, optionally one or more elements selected from Ca≦0.01% and Mg≦0.01%, with the balance being Fe and impurities, and the formula of “0.5Cu+Mo≧6.5” is satisfied. The material has a surface hardness of a Vickers hardness of not less than 350 at 500° C., a corrosion resistance equivalent to that of Ni based alloys having high Mo contents, and excellent erosion resistance in a severe environment.
US08858874B2 Ternary nickel eutectic alloy
A ternary nickel eutectic alloy consisting of 4.5 to 11 wt % chromium, 1 to 6 wt % cobalt, 1 to 4 wt % aluminum, 0 to 1.5 wt % titanium, 0 to 3 wt % tantalum, 16 to 22 wt % niobium, 0 to 3 wt % molybdenum, 0 to 4 wt % tungsten, 0 to 1 wt % hafnium, 0 to 0.1 wt % zirconium, 0 to 0.1 wt % silicon, 0.01 to 0.1 wt % carbon, 0 to 0.01 wt % boron and the balance nickel plus incidental impurities.
US08858868B2 Temperature regulated vessel
Disclosed is a temperature regulated vessel, and method for using the same, having a body configured to melt meltable material received therein, and one or more temperature regulating lines within the body configured to flow a liquid therein for regulating a temperature of the meltable material received in the melting portion. The vessel has a poor or low thermally conductive material on one or more of its parts, such as on the melting portion, on exterior surfaces of the body, and/or surrounding the temperature regulating lines to increase melt temperature of the material. The melting portion can also have indentations in its surface, and low thermally conductive material can be provided in the indentations. The vessel can be used to melt amorphous alloys, for example.
US08858866B2 Cooling tank for rails
A cooling tank for the thermal treatment of the head of rails, whose frame allows obtaining a stable and on average uniform flow of the cooling fluid which touches the head of the immersed rail along the entire tank, with the continuous exchange of the fluid so as to optimize the cooling speed of the head of the rail.
US08858865B2 Silicon nitride substrate manufacturing method, silicon nitride substrate, silicon nitride circuit substrate, and semiconductor module
A manufacturing method with which a high thermal conductivity silicon nitride substrate having excellent sintering performance can be manufactured without the occurrence of a molding crack or degreasing crack, as well as to provide a silicon nitride substrate, and a silicon nitride circuit board and a semiconductor module using the silicon nitride substrate. In the manufacturing method, in which a slurry is produced by mixing a silicon nitride powder, a sintering additive powder, and a binder in an organic solvent which is a dispersion medium, and the slurry is formed into a sheet, followed by degreasing and sintering, the oxygen content of the silicon nitride powder is 2.0 mass % or less and the specific surface area of the same is 3 to 11 m2/g, the additive ratio of the sintering additive powder is 4 to 15 mol %, and the water content ratio of the organic solvent is 0.03 to 3 mass %.
US08858858B2 Method of forming container with a tool having an articulated section
A method of forming a container from a construct. The method includes obtaining a tool having a cavity, a core, and an articulated section for being moveable within the cavity relative to the cavity and the core. The method further includes placing a construct between the cavity and the core, moving the core relative to the cavity so that the articulated section at least partially initially grips a portion of the construct, and further moving the core into the cavity. The portion of the construct remains gripped by the articulated section in the cavity during the further moving of the core.
US08858854B2 System and method for plastic overmolding on a metal surface
A plastic-metal hybrid part includes an anodized metal substrate having plastic structures formed on the metal substrate. In a particular embodiment, the metal hybrid part is an electronic device enclosure and plastic structures are mounting features formed on the enclosure. Methods for manufacturing the plastic-metal hybrid part are also disclosed. In a particular embodiment, the metal substrate undergoes a pretreatment, is anodized after the pretreatment, and the plastic structures are molded directly on the anodized exterior surface of the metal substrate. In another embodiment, the anodized metal substrate is primed with a coupling agent before the plastic features are formed thereon.
US08858852B2 Process and plant for producing tyres
A compound plant for processing elastomeric compounds for tires with both a high quality and a high throughput includes at least one batch mixing device in combination with at least one multi-shaft continuous mixing device having a high number of shafts. For example, the multi-shaft continuous mixing device could be a ring extruder having a plurality of co-rotating screws disposed to form a ring. In operation, a first elastomeric compound is discharged from the at least one batch mixing device and processed with the at least one multi-shaft continuous mixing device to obtain a second elastomeric compound.
US08858850B2 Process for preparing decorative surface appearance in acrylic material employing anisotropic particles
A decorative surface appearance in an acrylic material is obtained by applying a flowable crosslinkable acrylic material containing anisotropic particles having an aspect ratio of 3 to a shrinkable support followed by crosslinking to form a solid article.
US08858845B2 Systems and methods for the production of microfibers and nanofibers using a fluid level sensor
Described herein are apparatuses and methods of creating fibers, such as microfibers and nanofibers. The methods discussed herein employ centrifugal forces to transform material into fibers. Apparatuses that may be used to create fibers are also described. Described herein are fiber producing devices that have various types of outlet elements coupled to the fiber producing device.
US08858841B2 Aluminum paste composition and solar cell element using the same
An aluminum paste composition is provided, which comprises: (a) an aluminum powder, (b) a glass grit, (c) a binder, and (d) a dispersing agent. A solar cell element is further provided, which includes an electrode or wire formed by coating the aluminum paste composition on a silicon semiconductor substrate and drying and sintering it. The dispersing agent contained in the aluminum paste composition of the present invention has good moisture resistance and is capable of effectively addressing the warping problem of a solar cell and improving the adhesion between the backside aluminum paste and the silver paste of the solar cell.
US08858840B2 Nano-sulfur composite anode material for rare earth lithium-sulfur battery and its preparation method thereof
A nano-sulfur composite anode material for rare earth lithium-sulfur battery and its preparation method thereof, wherein the preparation method includes the steps of providing a carbon nanotube and sublimed sulfur, adjusting concentration based on percentage weight, mixing by milling, burning under negative pressure in Argon gas for 5 hours at 200° C.˜300° C. and 300° C.˜400° C. respectively, and obtaining a final product of nano-sulfur composite anode material for rare earth lithium-sulfur battery. By means of the preparation method of the present invention, the nano-sulfur composite anode material has a particle size <1 micron, a high capacity which is greater than 1000 mAh/g, and a long cycle life (>1000 times). The preparation method has the advantages of simple, low cost and high performance, thereby suitable for industrial production. The rare earth lithium-sulfur battery with the nano-sulfur composite anode material has the advantageous features of high energy density, high cycle performance, environmental friendly and low cost.
US08858836B2 Borophosphate phosphor and light source
This invention is related to efficient inorganic borophosphate phosphors which can applied in various technical applications such as fluorescent lamps, colored light or white light emitting diodes, and other devices where phosphors are used to convert especially near UV radiation into the visible light. Further, this invention is related to light sources comprising the efficient borophosphate phosphor. The inventive phosphor absorbs radiation in a first wavelength range of the electromagnetic spectrum and emits radiation in a second wavelength range of the electromagnetic spectrum. This phosphor is a borophosphate activated with divalent rare earth metal ions.
US08858834B2 Co-doped 1-1-2 nitrides
The invention relates to compounds of the formula (I): (Ca,Sr,Ba)1-x-yMeySiN2:Eux, where Me═Mn2+, Mg2+, Be2+, Ni2+, Co2+ and/or Ru2+; x=0.005 to 0.20; and y<1, and/or of the formula (II): (Ca,Sr,Ba)2-xSi1-zMazN2:Eux, where Ma═Hf4+, Th4+ and/or Zr4+; x=0.005 to 0.20; and z<1, and to a process for the preparation of these compounds, and to the use as phosphors and conversion phosphors for conversion of the blue or near-UV emission from an LED.
US08858827B2 Water treatment agent for removing pollutant by reinforcing potassium permanganate with intermediate manganes
A water treatment agent for removing pollutant by reinforcing potassium permanganate with intermediate manganese consists of a potassium permanganate and a chelating agent, or, alternatively, consists of a potassium permanganate, a chelating agent and an inducer. The chelating agent is capable of forming a coordination complex with the intermediate manganese which is produced during the reaction of potassium permanganate and organic substance. Thus self decomposition of intermediate manganese is reduced so that the effective utilization rate is increased and the capability for potassium permanganate to degrade organic pollutants is enhanced. The inducer accelerates the production of the intermediate manganese and increases the utilization rate so that the capability of potassium permanganate for degrading the organic pollutants is further enhanced.
US08858825B2 Heat transfer compositions comprising 2,3,3,3-tetrafluoropropene and ammonia
The invention relates to a composition comprising: a heat-transfer fluid comprising from 15% to 30% ammonia and from 70% to 85% 2,3,3,3-tetrafluoropropene; and a lubricant oil comprising a polyalkylene glycol. The invention also relates to the use of ammonia for increasing the miscibility of 2,3,3,3-tetrafluoropropene with the polyalkylene glycol, and vice versa.
US08858820B2 Bromofluorocarbon compositions
Compositions are described that may be used for applications such as a fire extinguishing composition in fire extinguishing unit, refrigeration, and the like. These compositions include halocarbons and additives that may stabilize the composition in the presence of a metal, water, and/or air. For example, the compositions may include a bromofluorocarbon, such as a bromofluoroalkene, an acid scavenger stabilizer, and an antioxidant stabilizer.
US08858808B2 Method of thin printed circuit board wet process consistency on the same carrier
A method of thin printed circuit board wet process consistency on the same carrier, and more particularly to a printed circuit board in the developing, copper plating, stripping, etching and other wet processes uses the same frame as a carrier from the beginning to the end of the wet process, such that the thin printed circuit board is conducted a continuous and automatic wet process to avoid disassembly, storage and transportation between each process. Moreover, when using the flame, the thin printed circuit board is smooth and flattening in the wet process for avoiding “water effect,” the effective area is not exposed to any mechanical members for preventing scratches, and there are point contacts between the thin printed circuit board and the frame for preventing chemical residue. Accordingly, the present invention can not only enhance the yield of the thin printed circuit board but also shorten the production time.
US08858803B2 Methods of preparing novel halide anion free quaternary ammonium salt monomers, polymerization methods therefor, and methods of use of the resulting polymers
Methods are provided for making halide-free quaternary ammonium salt monomers. Polymers prepared from the monomers and methods of using the polymers to clarify raw, untreated water or wastewater are also disclosed.
US08858796B2 Assembly for water filtration using a tube manifold to minimise backwash
A membrane filtration assembly (10) including having a filtrate carrier (9) for minimizing backwash. The membrane filtration assembly includes a membrane module (5) having one or more permeable hollow membranes (6) supported therein by an upper header (7) and a lower header (8). The filtrate carrier (9) extends between the upper (7) and lower (8) headers to allow filtrate to be collected from either or both ends of membranes (6). A filtrate collection chamber (18) is associated with the upper (7) and lower headers (9) and in fluid communication with lumens of the membranes (6) for collecting filtrate withdrawn through said membrane lumens. A filtration chamber (11) is provided for receiving feed liquid to be applied to the surface of membranes (6) within the module (5). The filtration chamber (11) includes an open end for receiving the feed liquid. The open end is located beyond the height of the module (5) to enable gravity feed.
US08858794B2 Sediment collecting container
A waste/sediment collecting container has a front vertical wall, a back vertical wall, two side vertical walls, and a sloped bottom surface. Along the lowest portion of the sloped floor surface lays a debris grate which allows water and pieces of sediment to pass through (but prevents larger pieces of waste from passing). The collection container includes a sump directly beneath the debris grate for collecting heavy sediment which passes through the grate. Sloped walls along the sides of the sump lead to U-traps on both sides of the container that allow liquid to pass through but prevent any solid waste from leaving the sump. Solid waste may be removed from the sump by removing the threaded service cap from the drain hole. Located beyond the traps are filter chambers having drain holes for inserting sediment filters which liquid passes through and exits the container.
US08858793B2 Filter, filter element, fastening housing part of a filter housing and telescopic switching element of a switching device of a releasable detent connection
A filter (18) is fastened by means of a releasable detent connection (20) in a fastening housing part (14). One detent component (32) is connected to the filter element (18) and one detent component (36) is connected to the fastening housing part (14). At least one detent means (32) of one of the detent components engages in a bayonet-like manner in a cut-out (38) in the other detent component (36). One switching component (60) of a switching device (58) is connected to the filter element (18) and one switching component (62) is connected to the fastening housing part (14). One of the switching components (60) includes at least one switching lug (76) extending radially to a rotational/plug-in axis (30) of the filter (10), and one of the switching components (62) includes a switching slot (78) for guiding the switching lug (76). The switching slot (78) guides the switching lug (76) and thereby effects a rotational movement of the filter element (18) relative to the fastening housing part (14 to move the detent means (32) out of an insertion/withdrawal region (46) into a closing region (40) of the cut-out (38), or out of a retaining region (42) into the insertion/withdrawal region (46).
US08858782B2 Ion-sensing charge-accumulation circuits and methods
An ion-sensitive circuit can include a charge accumulation device, to accumulate a plurality of charge packets as a function of an ion concentration of a fluid, and at least one control and readout transistor, to generate an output signal as a function of the accumulated plurality of charge packets, the output signal representing the ion concentration of the solution. The charge accumulation device can include a first charge control electrode above a first electrode semiconductor region, an electrically floating gate structure above a gate semiconductor region and below an ion-sensitive passivation surface, a second charge control electrode above a second electrode semiconductor region, and a drain diffusion region. The first control electrode can control entry of charge into a gate semiconductor region in response to a first control signal. The ion-sensitive passivation surface can be configured to receive the fluid. The second charge control electrode can control transmission of the plurality of charge packets out of the gate semiconductor region and into the drain diffusion region in response to a second control signal. The drain diffusion region can receive the plurality of charge packets from the gate semiconductor region via the second electrode semiconductor region.