| Document | Document Title |
|---|---|
| US08569787B2 |
Light source apparatus using semiconductor light emitting device
According to one embodiment, a light source apparatus includes a semiconductor light emitting device, a mounting substrate, first and second connection members. The semiconductor light emitting device includes a light emitting unit, first and second conductive members, a sealing member, and an optical layer. The mounting substrate includes a base body, first and second substrate electrodes. The connection member electrically connects the conductive member to the substrate electrode. The conductive member is electrically connected to the light emitting unit electrode and includes first and second columnar portions provided on the second major surface. The sealing member covers side surfaces of the first and the second conductive members. The optical layer is provided on the first major surface of the semiconductor stacked body and includes a wavelength conversion unit. A surface area of the second substrate electrode is not less than 100 times a cross-sectional area of the second columnar portion. |
| US08569786B2 |
Light emitting device and illumination device
According to one embodiment, a light emitting device includes a substrate, a light emitting element and connectors. The substrate has a surface and a back face, and power supply terminals are formed on the surface. The light emitting element is mounted on the surface of the substrate. The connector includes a contact portion coming into contact with the power supply terminal on the surface side of the substrate and a connector terminal having a wire connection portion projecting on the back face side of the substrate, and a power supply wire is connected to the wire connection portion of the connector terminal. |
| US08569785B2 |
Semiconductor light source for illuminating a physical space including a 3-dimensional lead frame
The present invention is a semiconductor light source 100 for illuminating physical spaces including a lead frame with multiple facets 101. Each facet can have one or more semiconductor light emitting devices 108, such as LEDs, located on it. The light source is disclosed in threaded 100, surface mounted 400, and bar light 700 configurations. |
| US08569784B2 |
Light emitting device and method for manufacturing the same
A light emitting device according to an embodiment includes a second electrode layer comprising at least one projection part; at least one current blocking layer on the projection part of the second electrode layer; a second conductive type semiconductor layer on the second electrode layer and the current blocking layer; an active layer on the second conductive type semiconductor layer; a first conductive type semiconductor layer on the active layer; and a first electrode layer on the first conductive type semiconductor layer, at least a portion of the first electrode layer corresponding with the current blocking layer in a vertical direction. |
| US08569782B2 |
Optoelectronic semiconductor component
An optoelectronic semiconductor component includes a housing main body and at least one optoelectronic semiconductor chip mounted on the housing main body. In operation, the optoelectronic semiconductor chip emits primary radiation including an ultraviolet radiation fraction. The semiconductor component also includes a filter medium that absorbs the ultraviolet radiation fraction and is located at least in part between the semiconductor chip and the housing main body and/or between the semiconductor chip and an optical component. |
| US08569779B2 |
Light emitting diode package
An exemplary light emitting diode (LED) package includes a substrate, an electrical member formed on the substrate, an LED chip mounted on the substrate and electrically connected to the electrical member, and a heat-dissipating member formed on the electrical member. The heat-dissipating member helps the LED chip to dissipate heat generated thereby when the LED chip is in operation. |
| US08569776B2 |
Nitride-based semiconductor light-emitting device and manufacturing method thereof
A nitride-based semiconductor light-emitting device and a manufacturing method thereof are provided. The nitride-based light-emitting device includes a first conductivity type nitride-based semiconductor layer, a light-emitting layer and a second conductivity type nitride-based semiconductor layer, that are successively layered above a translucent base. A first conductivity type electrode layer is electrically connected to the first conductivity type nitride-based semiconductor layer, and a second conductivity type electrode layer is electrically connected to the second conductivity type nitride-based semiconductor layer. |
| US08569775B2 |
Light-emitting diode (LED) array
An LED array having N light-emitting diode units (N≧3) comprises a permanent substrate, a bonding layer on the permanent substrate, a second conductive layer on the bonding layer, a second isolation layer on the second conductive layer, a crossover metal layer on the second isolation layer, a first isolation layer on the crossover metal layer, a conductive connecting layer on the first isolation layer, an epitaxial structure on the conductive connecting layer, and a first electrode layer on the epitaxial structure. The light-emitting diode units are electrically connected with each other by the crossover metal layer. |
| US08569774B2 |
Organic EL display panel and method of manufacturing the same
An organic electroluminescence (EL) display panel and method of manufacturing an organic EL display panel. The display panel includes a substrate on which a thin-film transistor layer is formed, with an interlayer insulating film formed above the thin-film transistor layer. A plurality of strip-shaped barrier ribs are arranged in parallel on the interlayer insulating film. Each electrode of a plurality of first electrode groups has first electrodes arranged in a line and arranged between two adjacent barrier ribs of the plurality of strip-shaped barrier ribs, with each of the first electrodes including a transparent conductive film and a reflective metal film formed of a metal material. A plurality of light-emitting layers are each formed to cover a different electrode of the plurality of first electrode groups, while a second electrode is formed above the plurality of light-emitting layers. Each electrode of the plurality of first electrode groups is formed such that an end portion of the first electrode in a parallel direction with respect to the barrier ribs includes a single-film portion in which the transparent conductive film is not formed, and a portion of the first electrode other than the single-film portion includes a two-film portion in which the transparent conductive film is layered on the reflective metal film. A metal oxide film is formed on an entire surface of the single-film portion of each first electrode by partially oxidizing the metal material. |
| US08569772B2 |
Light-emitting element and method of fabricating the same
Provided are a light-emitting element and a method of fabricating the same. The light-emitting element includes: a first pattern including conductive regions and non-conductive regions. The non-conductive regions are defined by the conductive regions. The light-emitting element also include an insulating pattern including insulating regions and non-insulating regions which correspond respectively to the conductive regions and non-conductive regions. The non-insulating regions are defined by the insulating regions. The light-emitting element further includes a light-emitting structure interposed between the first pattern and the insulating pattern. The light-emitting structure includes a first semiconductor pattern of a first conductivity type, a light-emitting pattern, and a second semiconductor pattern of a second conductivity type which are stacked sequentially. The light-emitting element also includes a second pattern formed in the non-insulating regions. |
| US08569766B2 |
Organic light-emitting display device and method of manufacturing the same
Disclosed is an organic light-emitting display device including a transparent substrate which includes a display portion and a pad portion formed in a region around the display portion, a first semiconductor layer formed on the display portion, a second semiconductor layer formed on the pad portion, and a transparent electrode formed on each of the first the second semiconductor layers, where the first and second semiconductor layers include the same material. |
| US08569765B2 |
MOSFET-Schottky rectifier-diode integrated circuits with trench contact structures
A trench MOSFET device with embedded Schottky rectifier, Gate-Drain and Gate-Source clamp diodes on single chip is formed to achieve device shrinkage and performance improvement. The present semiconductor devices achieve low Vf and reverse leakage current for embedded Schottky rectifier, have overvoltage protection for Gate-Source clamp diode and avalanche protection for Gate-Drain clamp diode. |
| US08569749B2 |
Organic light emitting diode display having getter and method of manufacturing the same
An organic light emitting diode (OLED) display is disclosed. In one embodiment, the OLED display includes first and second substrates, an OLED interposed between the first and second substrates and an external sealant formed between the first and second substrates and configured to i) substantially seal the first and second substrates and ii) substantially surround the OLED. The OLED display may further include a dam formed between the external sealant and the OLED and configured to substantially surround the OLED, and a getter formed between the external sealant and the dam. |
| US08569741B2 |
Electronic arrangements for passivated silicon nanowires
Methods for fabricating passivated silicon nanowires and an electronic arrangement thus obtained are described. Such arrangements may comprise a metal-oxide-semiconductor (MOS) structure such that the arrangements may be utilized for MOS field-effect transistors (MOSFETs) or opto-electronic switches. |
| US08569740B2 |
High efficiency thermoelectric materials and devices
Growth of thermoelectric materials in the form of quantum well superlattices on three-dimensionally structured substrates provide the means to achieve high conversion efficiency of the thermoelectric module combined with inexpensiveness of fabrication and compatibility with large scale production. Thermoelectric devices utilizing thermoelectric materials in the form of quantum well semiconductor superlattices grown on three-dimensionally structured substrates provide improved thermoelectric characteristics that can be used for power generation, cooling and other applications. |
| US08569728B2 |
Nonvolatile memory with variable resistance change layers
A nonvolatile memory device includes: a first conductive layer; a second conductive layer; a first resistance change layer provided between the first conductive layer and the second conductive layer and having an electrical resistance changing with at least one of an applied electric field and a passed current; and a first lateral layer provided on a lateral surface of the first resistance change layer and having an oxygen concentration higher than an oxygen concentration in the first resistance change layer. |
| US08569724B2 |
Induction heated buffer gas heat pipe for use in an extreme ultraviolet source
The successful use of lithium vapor in an extreme ultraviolet (EUV) light source depends upon an intense localized heat source at the center of conical structures that evaporate, condense and re-supply liquid lithium. Induction heating of a hollow structure with toroidal topology via an internal helical field coil, can supply intense heat at its innermost radius. The resulting slim radio frequency heated structure has high optical transmission from a central EUV producing plasma to collection mirrors outside of the structure, improving EUV source efficiency and reliability. |
| US08569719B2 |
Method and apparatus for specimen fabrication
A focused ion beam apparatus, including: a sample holder provided with a fixing surface for fixing, via a deposition film, a micro-specimen extracted from a specimen using a method for fabrication by a focused ion beam, in which a width of the fixing surface is smaller than 50 microns; a specimen transferring unit having a probe to which the specimen can be joined through the deposition film, and transferring the micro-specimen extracted from the specimen by the focused ion-beam fabrication method, to the sample holder; and a sample chamber in which the sample, the sample holder and the probe are laid out, wherein, in the sample chamber, the micro-specimen extracted from the specimen by the focused ion-beam fabrication method is fixed to the fixing surface of the sample holder through the deposition film, and the micro-specimen fixed to the fixing surface is fabricated by irradiating the focused ion beam. |
| US08569716B2 |
Optoelectronic sensor system
The underlying objective is to create an optoelectronic sensor system which illuminates the specimen homogenously and only allows produced fluorescent light to reach the photoactive layer. The objective is achieved substantially by creating a total reflection layer for the introduced light before or above the optoelectronic sensor layer. This can be applied in all fields in which microarray biochips are used. |
| US08569714B2 |
Double tilt transmission electron microscope sample holder for in-situ measurement of microstructures
A double tilt sample holder for in-situ measuring mechanical and electrical properties of microstructures in transmission electron microscope (TEM) is provided. The sample holder includes a home-made hollow sample holder body, a sensor for measuring mechanical/electrical properties, a pressing piece, a sample holder head, a sensor carrier. The sensor for measuring mechanical/electrical properties is fixed on the sensor carrier on the sample holder head by the pressing piece, while the sensor carrier is connected to the sample holder head through a pair of supporting shafts located on sides of the sample holder head. The sensor carrier can tilt within the plane perpendicular to the ample holder head by revolving around the supporting shafts (i.e. tilting along Y axis at an angle of ±30°). The sample holder also allows obtaining mechanical/electrical parameters concurrently. |
| US08569712B2 |
Beam blanker for interrupting a beam of charged particles
The invention relates to an electrostatic beam blanker for a particle-optical apparatus, in which the blanker is used to generate a train of pulses with a fixed repetition rate. Such pulse trains with a sub-picosecond pulse length are for example used in the study of chemistry in the femtosecond scale.The beam blanker according to the invention uses a resonant structure, as a result of which the voltage is amplified by the quality factor Q of the resonant structure. During each zero-crossing of the signal, thus twice per period of the resonant frequency, the beam is transmitted, and the beam is blanked during the rest of the time. In a preferred embodiment the resonant structure comprises a transmission line. Impedance matching of signal source and resonant structure may be performed by tuning stubs. |
| US08569710B2 |
Optimized detection of fission neutrons using boron coated straw detectors distributed in moderator material
The present invention includes an apparatus and method for neutron radiation detection. The apparatus comprises combining thin walled, boron-coated straw tubes with a plastic moderator material interspersed around the tubes. The method involves using such an apparatus through application of voltage to a central wire running inside the tubes and collecting electrical pulses generated thereby. |
| US08569702B2 |
Optical multiphase flowmeter
Method and apparatus enable direct measurement of at least one flow velocity for one or more phases within a multiphase fluid mixture flowing in a conduit. Some embodiments provide determination of actual individual phase flow rates for three phases (e.g., oil, water and gas) that are distinct from one another within the fluid mixture. A multiphase flowmeter according to embodiments of the invention includes at least two optical sensors spatially distributed along a length of the conduit and designed to detect light interactions with the fluid mixture unique to the phases such that detected time-varying signals can be processed via cross-correlation or an array processing algorithm to provide desired individual phase flow velocity for oil, water and/or gas phases. This flow velocity can be applied to phase fraction measurements, which can be obtained utilizing the same flowmeter or another separate device, to calculate the flow rates for the phases. |
| US08569691B2 |
Preconcentrator for analysis instruments
An interchangeable preconcentrator assembly for delivering an analyte to an analysis instrument. The assembly includes a housing defining an inner chamber. An inlet is in fluid communication with the inner chamber, an outlet is in fluid communication with the inner chamber for delivering fluid to the inlet of the analysis instrument, and an exhaust outlet is in fluid communication with the inner chamber. A plurality of removable preconcentrator packages are disposed within the inner chamber. Each of the removable preconcentrator packages including a microscale preconcentrator. A fluid flow path is defined between the inlet and the inner chamber. A first fluid flow path is defined between the preconcentrators and the exhaust outlet, and a second fluid flow path is defined between the preconcentrators and the outlet. A selectably operable valve directs fluid flow from the inner chamber into either the first fluid flow path or the second fluid flow path. |
| US08569687B2 |
Mass spectrometer
A mass spectrometer is disclosed comprising an ion mobility spectrometer or separator and an ion guide arranged downstream of the ion mobility spectrometer or separator. A plurality of axial potential wells are created in the ion guide so that ions received from the ion mobility spectrometer or separator become confined in separate axial potential wells. The potential wells maintain the fidelity and/or composition of ions received from the ion mobility spectrometer or separator. The potential wells are translated along the length of the ion guide. |
| US08569683B2 |
Method and device for monitoring an automatic drift compensation
A device for monitoring an automatic drift compensation of a scintillation counter may include a drift compensation monitoring unit which is designed to evaluate a counting rate caused by a monitoring radiation source for the purpose of monitoring the automatic drift compensation. |
| US08569679B2 |
System and circuit including multiple photo detectors and at least one optical barrier
A system includes a plurality of photo detectors, which generate signals proportional to incident light. The system further includes an optical barrier adjacent to a surface and includes a control circuit. The optical barrier partially obstructs reflected light from reaching the plurality of photo detectors to produce a spatially dependent reflectance pattern that is dependent on a position of an object relative to a substrate. The control circuit determines a position of the object during a reflectance measurement cycle using each of the plurality of photo detectors by calibrating to ambient light conditions, measuring ambient plus reflected light, determining the reflected light and detecting the position of the object based on a ratio of the reflected light received by at least two of the plurality of photo detectors. |
| US08569678B2 |
Micron-scale lens array having diffracting structures
A novel micron-scale lens, a microlens, is engineered to concentrate light efficiently onto an area of interest, such as a small, light-sensitive detector element in an integrated electronic device. Existing microlens designs imitate the form of large-scale lenses and are less effective at small sizes. The microlenses described herein have been designed to accommodate diffraction effects, which dominate the behavior of light at small length scales. Thus a new class of light-concentrating optical elements with much higher relative performance has been created. Furthermore, the new designs are much easier to fabricate than previous designs. |
| US08569674B2 |
Multiplexed photocurrent monitoring circuit comprising current mirror circuits
A low cost photocurrent monitoring circuit is provided. A photocurrent monitoring circuit, which performs monitoring by converting photocurrents output from a plurality of photodiodes (PD1 to PDn) into voltage, includes: a multiplexer circuit (MUX) for selecting one of input terminals to establish a connection of the selected input terminal to an output terminal, wherein the photodiodes (PD1 to PDn) are respectively connected to the input terminals; and an amplifier (LA) for converting a photocurrent which flows from a selected photodiode via the multiplexer circuit (MUX) into a voltage, and for outputting the voltage. |
| US08569673B2 |
Image sensor with voltage-limiting device
An image sensor includes an active pixel, an amplifier stage, and a voltage-limiting stage. The active pixel is configured to generate an information signal. The amplifier stage is coupled to the active pixel and configured to amplify the information signal. The voltage-limiting stage is coupled to the amplifier stage and includes a current shunting device and a gain device. The current shunting device has a first terminal connected to an output of the amplifier stage, a second terminal connected to a reference voltage node, and a control terminal. The gain device is connected to the control terminal of the current shunting device and configured to decrease the voltage span required to cause the current shunting device to enter into a current shunting mode. |
| US08569672B2 |
Pixel of image sensor having electrically controllable pinning layer
Disclosed are a pinned photodiode having and electrically controllable pinning layer and an image sensor including the pinned photodiode. A predetermined voltage is applied to the pinning layer for the depletion duration of the photodiode in the image sensor, so that stable surface pinning is acquired and the uniform surface pinning is achieved between pixels. |
| US08569669B2 |
Navigation method for a missile
A SAR image recorded by a reconnaissance system is transferred as a reference edge image together with the data of the trajectory as a reference. The signal of the infrared seeker head of the missile is converted into a virtual SAR edge image and compared to the SAR reference image to calculate the precise position of the missile. |
| US08569668B2 |
Active vortex control system (AVOCS) and method for isolation of sensitive components from external environments
An active vortex control system (AVOCS) includes a set of primary injectors that inject gas into a cavity to generate a vortex in front of and possibly around components inside the cavity. The vortex interferes with an external flow field in an opening to the cavity to protect the components from the external environment. Sets of secondary injectors may inject gas at a reduced mass flow into the cavity to compensate for energy losses to maintain the coherence of the vortex. The AVOCS is well suited for use in windowless endo- and exo-atmospheric interceptors to protect the electro-optical imagers and optical components from Earth atmosphere. |
| US08569667B2 |
In-shell pasteurization of eggs
An in-shell egg pasteurization installation includes a temperature raising stage having a microwave cavity or microwave cavity portion into which microwaves can be radiated and a pasteurization stage having a microwave cavity or microwave cavity portion into which microwaves can be radiated. The installation is configured so as to provide radiant or conductive heat to an in-shell egg located in the temperature raising stage and to an in-shell egg located in the pasteurization stage, and to provide relative displacement between an in-shell egg and the microwave cavities or microwave cavity portions. |
| US08569665B2 |
Cookware with tarnish protected copper exterior
An article of cookware in the form of a cooking vessel exposes only a portion of a copper inner layer on the upper portion of the exterior sidewall. The layer does not change color or tarnish as it sufficiently distal from the bottom of the cooking vessel that it is not subject to direct heat and oxidation during normal use. The unique bright color of the native copper is further protected from tarnish caused by fingerprint by a protective coating that can withstand moderate heating. |
| US08569662B2 |
Oil stripping fryer unit
A continuous oil fryer used to fry food slices, such as potato chips, having an internal oil stripping capability. The fryer accumulates the steam produced by the frying process in a hood and utilizes such steam, after superheating the steam by passing it through a heat exchanger, to strip oil from product immediately upon removal from the hot oil bath by passing the superheated steam through a product bed while on an output conveyor. The superheated steam removes oil from the product on the output conveyor without increasing the moisture level of the product. The fryer therefore accomplishes the same function as a low-oil stripper without increasing the footprint of the frying unit and with less energy. |
| US08569661B2 |
Household appliance
A household appliance includes a first oven, a second oven disposed above the first oven and a shared housing surrounding the first and second ovens. The shared housing includes two separable parts defining a partition plane between the first and second ovens. At least one connecting element forms a hinged connection between the two separable parts of the shared housing. Control, operating and display elements are disposed in a top part of the shared housing. |
| US08569659B2 |
Heater-integrated canister unit
A heater-integrated canister unit may include a canister, a temperature controller integrally coupled with the canister to indirectly heat a charcoal inside the canister by increasing a temperature of a space in the canister, and an electronic control unit controlling the current supplied to the temperature controller. The temperature controller may be disposed at the opposite side of the evaporation gas intake port in the canister and support the charcoal or may be coupled to the outside of the canister by a seating slot formed in the canister. The temperature controller may include a heater plate transmitting the current by forming a positive electrode and a negative electrode, a connector supplying the current to the heater plate and a heater generating heat on the heater plate. |
| US08569658B2 |
Composite conductor, in particular for glow plugs for diesel engines
Composite conductor comprising a metallic conductor and a ceramic conductor or non-conductor, at least one of them being elongate, the two being connected with each other in an electrically conductive manner. The ceramic conductor or non-conductor and the metallic conductor are hard-soldered to each other by a contact surface extending obliquely to the longitudinal direction of the at least one elongate conductor, and has one of the conductors tapers at its end and the other conductor has a matching tapering recess. The tapering end of the conductor is fitted into the tapering recess. |
| US08569657B2 |
Soldering iron with replaceable tip
A soldering iron (and a desoldering iron) with a replaceable tip, which is releasably securable on the forward heat-conducting end of a soldering (or desoldering) iron heat assembly. The tip has a heat conducting core in a tip cap. Methods of manufacturing and using the tip are also disclosed. A method of manufacturing a replaceable soldering or desoldering iron tip can comprise preparing a cap having a base opening and at least substantially filling the cap through the base opening with a heat conducting material so that a tip core is formed in the cap, the tip core having a core face at the base opening. |
| US08569652B2 |
Incremental hybrid welding systems and methods
Embodiments of a welding power supply include an engine adapted to drive a generator to produce a first power and a energy storage device adapted to discharge energy to produce a second power. The welding power supply also includes control circuitry adapted to detect a commanded output. The control circuitry is adapted to meet the commanded output by controlling access to power from the energy storage device to produce the second power when the commanded output is below a first predetermined load level. The control circuitry is further adapted to meet the commanded output by controlling access to power from the engine and the energy storage device to produce the first power and the second power when the commanded output is above a second predetermined load level. |
| US08569650B2 |
Laser material removal methods and apparatus
Embodiments of the present invention generally provide methods and apparatus for material removal using lasers in the fabrication of solar cells. In one embodiment, an apparatus is provided that removes portions of a dielectric layer deposited on a solar cell substrate according to a desired pattern. In certain embodiments, methods for removing a portion of a material via a laser without damaging the underlying substrate are provided. In one embodiment, the intensity profile of the beam is adjusted so that the difference between the maximum and minimum intensity within a spot formed on a substrate surface is reduced to an optimum range. In one example, the substrate is positioned such that the peak intensity at the center versus the periphery of the substrate is lowered. In one embodiment, the pulse energy is improved to provide thermal stress and physical lift-off of a desired portion of a dielectric layer. |
| US08569641B2 |
Environmentally protected switch for water activated devices
An environmentally protected switch for activating a signalling device, such as a light source, powered by a battery and adapted for use with a conductive fluid. The switch comprises an open ended housing and a sensing element received within the housing along a longitudinal axis thereof, a tip of the sensing element being substantially flush with the open end. The sensing element is coupled to the signalling device for providing an electrical path connecting the battery and the signalling device. Upon submersion of the switch into the fluid and agitation of the switch, a surface tension at an interface between the fluid and the open end is broken and fluid penetrates the housing up to a predetermined depth to enable an electrical current to flow within the sensing element for closing the electrical path and activating the signalling device. |
| US08569637B2 |
Interlock apparatus for solid insulated switchgear
For a solid-insulated switchgear in which a main circuit switching mechanism and a ground circuit switching mechanism are provided laterally, and there is disclosed an interlock apparatus for the solid-insulated switchgear comprising a first interlock mechanism connected to a switching shaft of the ground circuit switching mechanism to press the on shaft of the main circuit switching mechanism to be at the locking position or release the on shaft of the main circuit switching mechanism; and a second interlock mechanism connected to the switching shaft of the main circuit switching mechanism in an interlocking manner to press the on shaft of the ground circuit switching mechanism to be at the locking position or release the on shaft of the ground circuit switching mechanism. |
| US08569634B2 |
Combination measuring device with hoppers having an arcuate arrangement
A combination measuring device has a combination measuring unit. The combination measuring unit has a dispersing section configured to radially disperse articles loaded thereinto from above, a plurality of head sections configured to receive the articles from the dispersing section, and an assembling section configured to assemble the articles, which are contained in hoppers of one or more of the head sections selected according to a target weight. The head sections are arranged on a line formed by cutting away a circular arc from a circle surrounding the dispersing section. |
| US08569632B2 |
Wiring board having through hole or non-through hole, and method for producing the same
There is provided a circuit board including a substrate having a hole. Inside the hole, a metal wiring is formed. The wiring is made of a solder alloy having a melting point of 100 to 600° C., and the metal wiring includes a polycrystalline region of the solder alloy. The metal wiring of the present invention is superior in conductivity. |
| US08569630B2 |
Flex-rigid wiring board and method for manufacturing the same
A flex-rigid wiring board having a flexible wiring board, a first insulation layer positioned adjacent to a side of the flexible board and having a first hole which penetrates through the first layer, a second insulation layer laminated over the flexible board and the first layer and having a second hole which penetrates through the second layer, the second hole of the second layer being formed along the axis of the first hole of the first layer, a first conductor structure formed in the first hole and including a filled conductor formed by filling plating in the first hole, and a second conductor structure formed in the second hole and including a filled conductor formed by filling plating in the second hole, the second conductor structure being formed along the axis of the first conductor structure and electrically connected to the first conductor structure. |
| US08569629B2 |
Flexible printed circuit board
An FPC board includes a base insulating layer. A plurality of wiring traces are formed on the base insulating layer. The adjacent wiring traces are arranged at a distance d from each other, and each wiring trace has a predetermined width and a thickness t1. Each transmission line pair is constituted by the two adjacent wiring traces of the plurality of wring traces. A ratio of the thickness t1 of the wiring trace to the distance d between the adjacent wiring traces is set to 0.8 or more. A cover insulating layer may be formed on the base insulating layer to cover the wiring traces. A metal layer having a predetermined thickness may be provided on a back surface of the base insulating layer. Furthermore, a differential impedance of each transmission line pair may be set to 100 Ω. |
| US08569626B2 |
Contact
A contact includes a solder bonding portion, an elastic contact portion, and a suction portion. An undersurface of the solder bonding portion is a solder bonding face which is to be solder bonded to the conductor pattern. The elastic contact portion is connected to one end of the solder bonding portion and bent over the solder bonding portion. When in contact with a conductive member, the elastic contact portion is pressed against the conductive member while being elastically deformed. The suction portion is connected to the solder bonding portion independently of the elastic contact portion. The suction portion is made a suction face for a suction nozzle of an automatic mounter, with its top end being arranged in parallel to the undersurface of the solder bonding portion on the conductive member side of the elastic contact portion. |
| US08569621B1 |
Electrical device cover
A cover for electrical devices is disclosed. Particular implementations include an electrical device cover configured to mount over an electrical device includes a lid having a flexible membrane. The lid is coupled by a hinge to a base and the cover includes a cord port in an edge of a surface of the cover. The lid is configured to expand through the flexible membrane to an expanded position to accommodate an electrical connector coupled with the electrical device. The lid may also be configured to reduce in depth as the lid retracts from the expanded position to a refracted position through the flexible membrane. |
| US08569617B2 |
Encapsulation housing reducing piece
An encapsulation housing reducing piece has a first flange and a second flange. The second flange has a reduced cross-section compared to the first flange. An encapsulation housing shell extends between the two flanges. The encapsulation housing shell has a plurality of even zones. Rotation symmetrical shell surface sections are arranged between the even zones. |
| US08569612B2 |
Junction box
A junction box electronically connected to a solar panel and connected to a plurality of solar cell strings connected in series includes a first bypass diode string and at least one second bypass diode. The first bypass diode string includes a plurality of first bypass diodes forwardly connected in series, and each of the plurality of first bypass diodes is connected to a corresponding one of the plurality of solar cell strings in parallel. The at least one second bypass diode connected to at least two neighboring solar cell strings in parallel, turns on to bypass the at least two neighboring solar cell strings upon the condition that the at least two neighboring solar cell strings are abnormal simultaneously. |
| US08569611B2 |
Backsheet of a solar cell
The present invention discloses a backsheet of a solar cell. The backsheet of a solar cell comprises, sequentially from bottom to top, a bottom plastic layer, at least a first insulating layer, a conductive water-proof layer, at least a second insulating layer formed on the conductive water-proof layer, and a weather-resistant layer formed on the second insulating layer. The voltage-resistant ability of the weather-resistant layer is usually about one-third of that of the ordinary insulating layer and the weather-resistant layer is usually has the problem of pinhole which usually results in the defect of arc fail. Therefore, the second insulating layer, in the present invention, deposited between the conductive water-proof layer and the weather-resistant layer, can increase the voltage-resistant ability of the weather-resistant layer and to prevent the pinhole and the arc fail problem. |
| US08569610B2 |
Light-emitting polymer
A light-emitting polymer composition includes a polysiloxane polymer having tritium that emits radiation and a wavelength-shifter chemically bonded to the polysiloxane polymer or a siloxane carrier dispersed within the polysiloxane polymer. The wavelength-shifter emits light in response to the radiation. |
| US08569608B2 |
Electronic harp
A harp comprising a body, a set of strings attached to the body, an optical pickup to generate an analog signal produced by the vibration of a string within the set of strings, at least one circuit board to convert the analog signals to a corresponding digital signal, wherein the digital signal is then processed. |
| US08569607B1 |
Method and reference beat time template generating apparatus for equal temperament tuning a piano
A method and apparatus that enables tuning a piano to exact equal temperament includes beat time template generator. The beat time template generator is provided a fundamental key describing the fixed pitch the reference key is tuned and a secondary key to be tuned. The beat time template generator determines all the harmonics of the fundamental key and the secondary key. A difference beat frequency for all the harmonics is calculated for the fundamental key and secondary key and one beat time is selected as a reference beat time template signal. The reference beat time template signal is then transferred to a speaker for reproduction. A piano tuner then adjusts the strings of the secondary key such that when the fundamental key and the secondary key are struck simultaneously, the beat time of the struck keys is identical to the reference beat time template signal from the beat time template generator. |
| US08569606B2 |
Music and light synchronization system
An apparatus for synchronizing light signals to a music input signal includes an analog to digital converter to generate a digital signal equivalent of the analog music input signal, an digital signal decoder to generate an output pulse width modulated signal that is representative of the tempo and the volume of the music input signal, a light driver unit that receives the output pulse width modulated signal to correspondingly light up a lighting unit, and a lighting unit that emits light. Thus, light brightness synchronizes with the music volume amplitude, and the light blinks on and off with the music tempo and beating. |
| US08569599B2 |
Plants and seeds of hybrid corn variety CH934907
According to the invention, there is provided seed and plants of the hybrid corn variety designated CH934907. The invention thus relates to the plants, seeds and tissue cultures of the variety CH934907, and to methods for producing a corn plant produced by crossing a corn plant of variety CH934907 with itself or with another corn plant, such as a plant of another variety. The invention further relates to genetic complements of plants of variety CH934907. |
| US08569598B2 |
Plants and seeds of hybrid corn variety CH163712
According to the invention, there is provided seed and plants of the hybrid corn variety designated CH163712. The invention thus relates to the plants, seeds and tissue cultures of the variety CH163712, and to methods for producing a corn plant produced by crossing a corn plant of variety CH163712 with itself or with another corn plant, such as a plant of another variety. The invention further relates to genetic complements of plants of variety CH163712. |
| US08569596B1 |
Maize variety inbred PH1DFR
A novel maize variety designated PH1DFR and seed, plants and plant parts thereof. Methods for producing a maize plant that comprise crossing maize variety PH1DFR with another maize plant. Methods for producing a maize plant containing in its genetic material one or more traits introgressed into PH1DFR through backcross conversion and/or transformation, and to the maize seed, plant and plant part produced thereby. Hybrid maize seed, plant or plant part produced by crossing the variety PH1DFR or a locus conversion of PH1DFR with another maize variety. |
| US08569591B1 |
Maize variety hybrid X08B704
A novel maize variety designated X08B704 and seed, plants and plant parts thereof, produced by crossing Pioneer Hi-Bred International, Inc. proprietary inbred maize varieties. Methods for producing a maize plant that comprises crossing hybrid maize variety X08B704 with another maize plant. Methods for producing a maize plant containing in its genetic material one or more traits introgressed into X08B704 through backcross conversion and/or transformation, and to the maize seed, plant and plant part produced thereby. This invention relates to the maize variety X08B704, the seed, the plant produced from the seed, and variants, mutants, and minor modifications of maize variety X08B704. This invention further relates to methods for producing maize varieties derived from maize variety X08B704. |
| US08569590B1 |
Soybean cultivar 08273775
A soybean cultivar designated 08273775 is disclosed. The invention relates to the seeds of soybean cultivar 08273775, to the plants of soybean cultivar 08273775, to the plant parts of soybean cultivar 08273775, and to methods for producing progeny of soybean cultivar 08273775. The invention also relates to methods for producing a soybean plant containing in its genetic material one or more transgenes and to the transgenic soybean plants and plant parts produced by those methods. The invention also relates to soybean cultivars or breeding cultivars, and plant parts derived from soybean cultivar 08273775. The invention also relates to methods for producing other soybean cultivars, lines, or plant parts derived from soybean cultivar 08273775, and to the soybean plants, varieties, and their parts derived from use of those methods. The invention further relates to hybrid soybean seeds, plants, and plant parts produced by crossing cultivar 08273775 with another soybean cultivar. |
| US08569582B2 |
Method for transformation of grasses
The invention provides methods for transforming grass plants with Agrobacterium. The invention allows creation of transgenic grass plants without the need for callus as a target tissue for transformation, thus providing a rapid method for the production of transgenic grass plants. Transgenic grass plants produced by this method are also provided. |
| US08569578B1 |
Generating transgenic potatoes with novel resistance to potato cyst nematodes by silencing nematode parasitism genes of CLE -1 and CLE-4s
Plant CLAVATA3/ESR-related (CLE) peptides have diverse roles in plant growth and development. We have isolated and characterized the function of five new CLE genes from the potato cyst nematode Globodera rostochiensis. Unlike typical plant CLEs that contain a single CLE motif, four of the five Gr-CLE genes encode CLE proteins with multiple CLE motifs. These Gr-CLEs were found to be specifically expressed within the dorsal esophageal gland cell of nematode parasitic stages, suggesting a role for their encoded proteins in plant parasitism. Overexpression of Gr-CLEs in Arabidopsis mimicked overexpression of plant CLEs and Gr-CLE proteins could rescue the Arabidopsis clv3-2 mutant phenotype when expressed within meristems. A short root phenotype was observed when synthetic GrCLE peptides were exogenously applied to roots of Arabidopsis or potato similar to the overexpression of Gr-CLEs in Arabidopsis and potato hairy roots. These results reveal that G. rostochiensis CLEs with either single or multiple CLE motifs function similarly to plant CLEs and that CLE signaling components are conserved in both Arabidopsis and potato roots. Transgenic potato hairy roots expressing Gr-CLE-1 or Gr-CLE-4 dsRNA were generated. There was an approximately 50% reduction in the average number of cysts per root in the Gr-CLE-1 or Gr-CLE-4 dsRNA transgenic lines when compared with the infected control lines, indicating that silencing nematode CLE genes through host-derived RNAi may generate novel resistance against potato cyst nematodes in transgenic potatoes. |
| US08569574B2 |
Methods and compositions for improved fertilization and embryonic survival
Single nucleotide polymorphic sites at positions 3117, 12195, 13244, 13319, and 13516 of the bovine STAT5 gene are associated with improved fertilization rate and/or improved embryo survival rate. Also disclosed are nucleic acid molecules, kits, methods of genotyping and marker assisted bovine breeding methods. |
| US08569570B2 |
Airlaid sheet material
The present invention relates to an airlaid sheet material comprising a dry laid fibrous web and a latex coating on both surfaces thereof in selected amounts. The airlaid sheet material can be an absorbent structure for absorption of fluids. |
| US08569569B2 |
Ultrathin fluid-absorbent cores
The present invention relates to ultrathin fluid-absorbent cores comprising a substrate layer, water-absorbent polymer particles and an adhesive, wherein the wet SAP shake out of water-absorbent polymer particles out of the fluid-absorbent core is less than 10% by weight. |
| US08569568B2 |
Article having improved fecal storage structure
An absorbent article comprising a liquid pervious topsheet, a liquid pervious backsheet joined to at least a portion of the topsheet, an absorbent core disposed between at least a portion of the topsheet and the backsheet, and a waste management element disposed in at least a portion of the crotch region. The waste management element preferably includes an acceptance element having an effective open area of at least about 30 percent and a storage element having a compressive resistance of at least about 70 percent. |
| US08569565B2 |
Process for recycling spent pot linings (SPL) from primary aluminium production
The present invention relates to a process for recycling SPL from primary aluminum production, comprising the steps of grinding the separated fractions or cuts, separating materials by means of mechanical treatment, mixing salt slags with SPL, dissolving in water the product obtained in the previous step, carrying out a chemical reaction between water and the materials to be made inert, sedimenting, removing cyanides, filtering to obtain a soluble fraction and another insoluble fraction, washing the insoluble fraction, crystallizing salts of the soluble fraction and aging or conditioning the insoluble fraction. The present invention further relates to the product obtained by means of said process and the use thereof in different fields of the art. |
| US08569562B2 |
Purification of isoprene from renewable resources
Methods and apparatus for the purification of isoprene, such as the purification of a bioisoprene composition from fermentor off-gas. The apparatus includes two columns that process the fermentor off-gas, which includes isoprene and various impurities. A solvent is added to the off-gas in the first column, and the isoprene is stripped from the solvent in the second column. Also provided is a downstream further purification process. Also provided are the resulting purified isoprene compositions. |
| US08569560B2 |
Synthesis of terminal alkenes from internal alkenes via olefin metathesis
This disclosure relates generally to olefin metathesis, and more particularly relates to the synthesis of terminal alkenes from internal alkenes using a cross-metathesis reaction catalyzed by an olefin metathesis catalyst. According to one aspect, for example, a method is provided for synthesizing a terminal olefin, the method comprising contacting, in the presence of a ruthenium alkylidene metathesis catalyst, an olefinic substrate comprised of at least one internal olefin with a cross metathesis partner comprised of an alpha olefinic reactant, under reaction conditions effective to allow cross-metathesis to occur, wherein the reaction conditions include a reaction temperature of at least 35° C. The methods, compositions, reactions and reaction systems herein disclosed have utility in the fields of catalysis, organic synthesis, and industrial chemistry. |
| US08569559B2 |
Paraxylene production process and apparatus
The invention concerns a process for the production of paraxylene and an apparatus suitable for said process. The process separates the overhead from a xylenes re-run into a xylene-rich stream and a xylene-lean stream. The xylene-lean stream is isomerized under conditions such that the xylenes are in the liquid phase. |
| US08569553B2 |
Process for producing 2,3,3,3-tetrafluoropropene
The object is to provide a process whereby it is possible to produce 2,3,3,3-tetrafluoropropene at a high conversion ratio constantly for a long period of time.A process for producing 2,3,3,3-tetrafluoropropene, which comprises reacting a raw material compound of at least one of 1,1-dichloro-2,3,3,3-tetrafluoropropene and 1-chloro-2,3,3,3-tetrafluoropropene, and hydrogen, in the presence of a catalyst, wherein the catalyst is a noble metal catalyst supported on a metal oxide having a Hammett acidity function value (H0) of at least −5.6. |
| US08569548B2 |
Process for the preparation of alkylene glycols
A process for the preparation of an alkylene glycol, said process comprising contacting an alkylene oxide with carbon dioxide and water in the presence of a catalytic composition comprising an active anion, selected from the group consisting of metalates, carbonate, bicarbonate and hydroxide, immobilized on a first solid support having one or more electropositive sites and a halide immobilized on the first or a second solid support having one or more electropositive sites. |
| US08569545B2 |
Process for the preparation of enantiomerically pure amines
The present invention relates to an improved process for the preparation of (R)-1-aminoindan (2), rasagiline (1) and pharmaceutically acceptable salts of rasagiline. |
| US08569544B2 |
Process for preparation of benzphetamine and its pharmaceutically acceptable salts
The present invention provides a simple method for preparation of benzphetamine and its acid addition salt comprising reaction of methamphetamine hydrochloride of formula (III) with benzyl chloride and treating the isolated benzphetamine of formula (II) with an acid dissolved in an organic solvent to provide benzphetamine acid addition salt, more specifically, benzphetamine hydrochloride of formula (I). |
| US08569542B2 |
Use of docosatrienes, resolvins, and their stable analogs in the treatment of airway diseases and asthma
The present invention is generally drawn to novel isolated therapeutic agents, termed resolvins, generated from the interaction between a dietary omega-3 polyunsaturated fatty acid (PUFA) such as eicosapentaenoic acid (EPA) or docosahexaenoic acid (DHA), cyclooxygenase-II (COX-2) and an analgesic, such as aspirin (ASA). Surprisingly, careful isolation of compounds generated from the combination of components in an appropriate environment provide di- and tri-hydroxy EPA or DHA compounds having unique structural and physiological properties. The present invention therefore provides for many new useful therapeutic di- or tri-hydroxy derivatives of EPA or DHA (resolvins) that diminish, prevent, or eliminate inflammation or PMN migration, for example. The present invention also provides methods of use, methods of preparation, and packaged pharmaceuticals for use as medicaments for the compounds disclosed throughout the specification. |
| US08569541B2 |
Optical element compound, optical material, and optical element
An optical material organic compound having characteristics that the dispersion characteristic (Abbe number (νd)) and the secondary dispersion characteristic (θg,F) of the refractive index are high, the transmittance in the visible light region is high, and the chromatic aberration correction function delivers high performance, which represented by the general formula (1) or (2) is provided. |
| US08569540B2 |
Stabilization of dicarbonate diesters with protonic acids
By using protonic acids, diesters of dicarbonic acid may be stabilized against thermal and chemical decomposition over a relatively long period. Mixtures of diesters of dicarbonic acid and protonic acids are outstandingly suitable for preserving foods. |
| US08569539B2 |
Process for preparing alpha-hydroxycarboxylic esters
Alpha-hydroxycarboxylic esters are prepared by a continuous process in which alpha-hydroxycarboxamide is reacted with an alcohol in the presence of a catalyst to obtain a product mixture which contains alpha-hydroxycarboxylic ester, ammonia, unconverted alpha-hydroxycarboxamide and alcohol, and catalyst; wherein reactant streams containing an alpha-hydroxycarboxamide, an alcohol and a catalyst are fed into a pressure reactor. The reactant streams are reacted with one another in the pressure reactor at a pressure in the range of 1 bar to 100 bar; and the product mixture is depleted in alcohol and ammonia by distilling off ammonia at a pressure which is constantly kept greater than 1 bar without the aid of additional stripping media. The continuous process can be employed particularly advantageously on the industrial scale. |
| US08569538B2 |
Acryloyl materials for molded plastics
In one aspect, the invention relates to methods of synthesizing acryloyl compounds, comprising the step of hydrosilylating a compound having the structure: with a compound having the structure A-H, wherein A comprises a siloxanyl group, to yield a compound having the structure: Compounds and compositions produced thereby can effectively attain a satisfactory balance between high oxygen permeability and hydrophilicity while achieving an acceptably low concentration of undesirable impurities. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention. |
| US08569537B2 |
Functionalized zirconia nanoparticles and high index films made therefrom
The present disclosure relates to surface-modified zirconia nanoparticles, methods for making and using the same, and high index of refraction films made therefrom. The provided zirconia nanoparticles are surface modified with ligands that include N-hydroxyurea functionalities. The provided ligands also can contain compatibilizing groups that allow the provided surface-modified zirconia nanoparticles to be incorporated into an organic matrix. High index of refraction films can be made using these organic matrices. |
| US08569532B2 |
Catalysts
A complex containing a ligand of formula (I): useful in the formation of olefin polymerization catalysts and their use in olefin polymerization. |
| US08569525B2 |
Process for producing ethylene oxide
The present invention provides a process for producing ethylene oxide, comprising (a) cracking an ethane-comprising feed in a cracking zone under cracking conditions to obtain olefins including at least ethylene and hydrogen; (b) converting an oxygenate feedstock in an oxygenate-to-olefin zone to obtain olefins, including at least ethylene; providing at least part of the ethylene obtained in step (a) and /or (b) to an ethylene oxidation zone together with a feed containing oxygen and oxidizing ethylene to obtain at least ethylene oxide and carbon dioxide. At least part of the oxygenate feedstock is obtained by providing carbon dioxide obtained in step (c) and a feed containing hydrogen to an oxygenate synthesis zone and synthesizing oxygenates, which feed containing hydrogen comprises hydrogen obtained in step (a). |
| US08569520B2 |
Crystal of spiroketal derivatives and process for preparation of spiroketal derivatives
The present invention provides a process for preparing a spiroketal derivative, via an intermediate represented by Formula (VI): wherein variable groups and numbers are as defined in the specification, which can be produced from dihalobenzene derivatives in one pot reaction. |
| US08569510B2 |
White-emitting compounds using excited-state intramolecular proton transfer, organic electroluminescent element and laser material using the same
Provided are a white-emitting monomolecular compound using excited-state intramolecular proton transfer (ESIPT) characteristics, and an organic electroluminescence device and a laser device comprising same. The white-emitting monomolecular compound according to the present invention is prepared by covalently bonding at least two types of molecules which produce different colors and have excited-state intramolecular proton transfer (ESIPT) characteristics. The white-emitting monomolecular compound according to the present invention achieves white luminescence irrespective of the concentration thereof and of the state of the materials thereof, and therefore can be used in a variety of fields including an organic electroluminescence device and a laser device. |
| US08569508B2 |
Synthetic method for montelukast sodium intermediate
A synthesis method for preparing Montelukast sodium intermediate 2-(2-(3-(2-(7-chloro-2-quinolyl)vinyl)phenyl-3-oxopropyl)phenyl) propanol is provided. In this method, the target compound is prepared by condensing the starting materials 7-chloroquinaldine and 3-cyanobenzaldehyde, and then reacting the resultant product with 2-(2-ortho-(2-haloethyl)-phenylpropyl)tetrahydropyrane ether. The present invention can easily obtain start materials and is applicable for mass production. |
| US08569503B2 |
Processes and intermediates for preparing fused heterocyclic kinase inhibitors
This invention relates to processes and intermediates for manufacturing fused heterocyclic-type kinase inhibitor compounds, such as thienopyridine-based compounds, and to processes and intermediates for preparing intermediates that are useful in the manufacture of fused heterocyclic-type kinase inhibitor compounds, such as thienopyridine-based compounds, particularly at an industrial level. |
| US08569502B2 |
Quaternary nitrogen heterocyclic compounds for detecting aqueous monosaccharides in physiological fluids
Quaternary nitrogen heterocyclic boronic acid-containing compounds are described, which are sensitive to glucose and fructose, as well as a variety of other physiologically important analytes, such as aqueous chloride and iodide, and a method of using the compounds. Also disclosed is a contact lens doped with the quaternary nitrogen heterocyclic boronic acid-containing compound, and a method of using the doped contact lens to measure the concentration of analyte in tears under physiological conditions. |
| US08569498B2 |
Process for the preparation of piperazine compounds and hydrochloride salts thereof
The invention relates to a new process for the preparation of compounds of general formula (I) whereinR1 and R2 represent independently hydrogen or C1-6 alkyl with straight or branched chain optionally substituted with aryl group, or C2-7 alkenyl containing 1-3 double bonds, or monocyclic, bicyclic or tricyclic aryl optionally substituted with one or more C1-6 alkoxy, trifluoro-C1-6 alkoxy, C1-6-alkoxycarbonil, C1-6alkanoyl, aryl, C1-6 alkylthio, halogen or cyano, or optionally substituted monocyclic, bicyclic or tricyclic C3-14 cycloalkyl group, R1 and R2 together with the adjacent nitrogen form a saturated or unsaturated optionally substituted monocyclic or bicyclic heterocyclic ring which may contain further heteroatoms selected from oxygen, nitrogen, or sulphur atoms and hydrochloric acid alts and/or hydrates and/or solvates thereof, by dissolving or suspending trans 4-{2-[4-(2,3-dichlorophenyl)-piperazine-1-il]-ethyl}-cyclohexylamine of formula (III) or a salt or a hydrate or a solvate thereof in an inert solvent in the presence a base then adding a carbonic acid derivative of general formula (VI) wherein R is alkyl with C1-6 straight or branched chain or C1-2 fully halogenated alkyl, Z is —O—R or —X, wherein R is as described above, X is halogen, and reacting the compound of general formula (IV) obtained wherein R is as described above, in situ or, optionally in isolated state with an amine of general formula (V) wherein R1 and R2 are as described above to obtain the compound of general formula (I) and then optionally forming the hydrochloride salts and/or hydrates and/or solvates thereof. |
| US08569497B2 |
Process for the preparation of piperazine derivatives
The invention relates to a process for the preparation of the trans N-{4-{2-[4-(2,3-dichlorophenyl)-piperazine-1-yl]-ethyl}-cyclohexyl}-carbamide derivatives of general formula (I) by reacting the compound of formula (III) with a carbamoylchloride of general formula (II) which comprises carrying out the reaction in a mixture of a solvent and concentrated aqueous solution of an alkali hydroxide at a temperature between 40-100° C. in the presence of a phase transfer catalyst, separating the phases and washing the organic layer then removing the solvent and drying the compound of formula (I) obtained until its weight is constant. |
| US08569496B2 |
Piperazine salt and a process for the preparation thereof
The invention relates to novel trans N-{4-{2-[4-(2,3-dichlorophenyl)-piperazine-1-il]-ethyl}-cyclohexylamine dihydrochloride monohydrate and a process for the preparation of the trans N-{4-{2-[4-(2,3-dichlorophenyl)-piperazine-1-il]-ethyl}-cyclohexylamine dihydrochloride monohydrate, said process comprising the stepsa) reacting trans 2-{1-[4-(N-tert-butoxycarbonyl)amino]-cyclohexyl}-acetic acid ester with sodium borohydride and aluminum trichloride to give trans 2-{1-[4-(N-tert-butoxycarbonyl)-amino]-cyclohexyl}-ethanol;b) reacting trans 2-{1-[4-(N-tert-butoxycarbonyl)-amino]cyclohexyl}-ethanol obtained with methanesulfonic acid chloride in the presence of an acid binding agent to give trans 2-{1-[4-(N-tert-butoxycarbonyl)-amino]-cyclohexyl}-ethyl methanesulfonate;c) reacting trans 2-{1-[4-(N-tert-butoxycarbonyl)-amino]-cyclohexyl}-ethyl methanesulfonate obtained with 2,3-dichlorophenyl-piperazine in the presence of an acid binding agent to give trans 2-{1-[4-(N-tert-butoxycarbonyl)-amino]-cyclohexyl}-carbamic acid tert-butylester; d) heating trans 2-{1-[4-(N-tert-butoxycarbonyl)-amino]-cyclohexyl}-carbamic acid tert-butylester obtained to a temperature between 40-100° C. in a mixture of aqueous hydrochloric acid/methanol to give trans N-{4-{2-[4-(2,3-dichlorophenyl)piperazine-1-il]-ethyl}-cyclohexylamine dihydrochloride monohydrate. |
| US08569495B2 |
Anthelmintic agents and their use
This invention is directed to compounds and salts that are generally useful as anthelmintic agents or as intermediates in processes for making anthelmintic agents. This invention also is directed to processes for making the compounds and salts, pharmaceutical compositions and kits comprising the compounds and salts, uses of the compounds and salts to make medicaments, and treatments comprising the administration of the compounds and salts to animals in need of the treatments. |
| US08569492B2 |
Method for preparing halofuginone derivative
A method for preparing a halofuginone derivative, in particular a method for preparing an inhibitor medicament expressed by specific I-type procollagen in the invention a condensate of formula (II) reacts for 12-35 hours in a catalytic hydrogenation solvent with the existence of Ni—B amorphous alloy catalyst, at the hydrogen pressure of 0.1-10 Mpa and at the temperature of 10-60° C., and then the catalyst is filtered, the filtrate is decompressed to recover the solvent, the pH value is regulated to obtain a crude product of formula (I), and the crude product of the formula (I) is refined to obtain a refined product of formula (I). |
| US08569488B2 |
Crystalline pyridazine compound
A crystalline compound of formula (1) and its salts and solvates are provided for the treatment or prophylaxis of hepatitis C virus infections Methods of making and formulating crystalline compound (1) are provided. |
| US08569485B2 |
Phenyl-substituted 1,3,5-triazine compound, process for producing the same, and organic electroluminescent device containing the same as component
A phenyl-substituted 1,3,5-triazine compound represented by the general formula (1): wherein Ar1 and Ar2 independently represent substituted or unsubstituted phenyl, naphthyl or biphenylyl group; R1, R2 and R3 independently represent hydrogen atom or methyl group; X1 and X2 independently represent substituted or unsubstituted phenylene, naphthylene or pyridylene group; p and q independently represent an integer of 0 to 2; and Ar3 and Ar4 independently represent substituted or unsubstituted pyridyl or phenyl group. This compound is suitable for an organic electroluminescent device. |
| US08569480B2 |
Hydroxyethylstarch
Described are a hydroxyethylstarch, a process for the preparation thereof, a pharmaceutical formulation containing such a hydroxyethylstarch, and the use of the pharmaceutical formulation for the preparation of a volume replacement, a plasma replacement or a plasma volume expander, as well as the use of the pharmaceutical formulation for maintaining normovolemia and/or for improving the macro- and microcirculation and/or for improving the nutritive oxygen supply and/or for stabilizing hemodynamics and/or for improving the volume efficiency and/or for reducing the plasma viscosity and/or for increasing anemia tolerance and/or for hemodilution, especially for therapeutic hemodilution in disturbed blood supply and arterial, especially peripheral arterial, occlusive diseases. |
| US08569471B2 |
Stem cell beacon
The invention relates to methods and compositions for selectively directing stem cells to a target tissue within a subject using a system that employs one or more vectors that contain a gene switch/biosensor, a tissue-specific promoter, a gene encoding a stem cell-attracting chemokine, and a gene amplification system. In one embodiment, a stem cell-attracting chemokine is expressed in damaged tissue using a stimulus-responsive vector system. The stimulus can be a physiological stimulus associated with cell injury, such as hypoxia or elevated glucose levels, for example. Expression of the chemokine increases the trafficking of stem cells to the damaged tissue. |
| US08569470B2 |
Engineered pertactin variants for vaccine use
The present invention is related with the field of Biomedicine. It comprises the engineering of the Pertactin protein (Prn) and using it as part of bacterial vaccines, and more precisely, as part of acellular vaccines against Bordetella pertusis. The engineered Prn molecules comprise on their structure polimorfisms from different B. pertussis strains, and induce immune responses with protective capacity and opsonophagocytic activity when assayed as vaccines, higher than that generated by other pre-existing vaccines. The engineered Prn variants of the present invention are applicable in human and veterinary medicine. |
| US08569465B2 |
Method for modifying lignin structure using monolignol ferulate conjugates
Described is an isolated lignified plant cell wall including lignin, wherein the lignin includes a ferulate residue incorporated therein, such as from coniferyl ferulate and/or sinapyl ferulate. Also described is a method to make the isolated lignified plant cell wall, and the lignin produced by the method. |
| US08569463B2 |
Method of covalently modifying proteins with organic molecules to prevent aggregation
A system and method for preventing protein aggregation is developed by covalent modification of proteins with organic molecules that can preserve the native protein folding. Proteins are covalently modified with sugar alcohols or cyclodextrins (organic Kosmotropes) or other small molecule drugs by water-driven bioorganic reactions in water. In the water-driven bioorganic reactions, the reagent is stable in water and can modify lysine residues or cysteine residue of a protein at physiological conditions with high yield and fast rate. Proteins and antibodies will be modified by non-natural sugar alcohols. As a result, the efficacy of protein drugs (reduction in aggregation and enzymatic degradation, and increase in blood stream life time) may be improved. |
| US08569455B2 |
Cloning, yeast expression, purification and biological activity of the extension region of the soybean 7S globulin alfa' subunit involved in HEP G2 cell cholesterol homeostasis
A truncated form of α′ chain (eα′), the soybean 7S globulin, active in controlling the cholesterol and triglyceride homeostasis in in vitro and in vivo models, was cloned and expressed in the yeast Pichia pastoris. The recombinant polypeptide spanned 142 amino acid residues from the N-terminal side and included the N-terminal extension region of the soybean alpha′ subunit. The eα′ polypeptide was purified by conventional biochemical techniques and its potential to modulate the activity of the LDL-receptor was evaluated in a human hepatoma cell line (Hep G2) by monitoring the uptake and degradation of labeled LDL. |
| US08569454B2 |
YS68 polypeptide involved in primitive hematopoiesis
A novel gene, dubbed “YS68”, involved in primitive hematopoiesis was successfully isolated from cDNA derived from mouse yolk sacs. In addition, a human gene corresponding to this gene was successfully isolated. Expression characteristics of these genes suggested their involvement in primitive hematopoiesis. The proteins of this invention and genes encoding the proteins may be utilized as tools for drug development against diseases, such as hematological disorders. |
| US08569453B2 |
Fluorene compound
Particular compounds having a fluorene skeleton are superior in broad utility and stability, as a protecting reagent for liquid phase synthesis of amino acids and/or peptides. |
| US08569446B2 |
Peptides effective in the treatment of tumors and other conditions requiring the removal or destruction of cells
The invention is directed to methods of treating conditions requiring removal or destruction of harmful or unwanted cells in a patient, such as benign and malignant tumors, using compounds containing or based on peptides comprising a part of the amino acid sequence of a neural thread protein. |
| US08569444B2 |
Polyalkylene glycol derivative and process for producing same
A process for producing a polyalkylene glycol derivative having such high molecular weight and purity that the derivative can be used in pharmaceutical applications, which produces a polyalkylene glycol derivative of the formula (X) by steps (A), (B), (C) and (D), wherein R is as defined: R—(OA)nOH (X) (step (A)) 5 to 50% by mol of an alkali catalyst is added to a compound represented by the formula (Y), wherein R is as defined: R—OH (Y) (step (B)) an alkylene oxide having 2 to 4 carbon atoms is reacted under a condition of 50 to 130° C. until the average number of moles of an oxyalkylene group OA added reaches the range of 5 to 500 to obtain a polyalkylene glycol derivative; (step (C)) 10 to 5000% by mass of a hydrocarbon solvent is added to the derivative of the step (B) to dilute it, and remaining water is removed by azeotropy; and (step (D)) the derivative of the step (B) is reacted with an alkylene oxide having 2 to 4 carbon atoms under a condition of 50 to 130° C. until the average number of moles of the oxyalkylene group (OA) reaches the range of 600 to 2000. |
| US08569442B2 |
Hydrogenation process for improving yield of hydrogenated bisphenol-A-based epoxy resin
A hydrogenation process for hydrogenating bisphenol-A-based epoxy resin under low-temperature, low-pressure conditions includes using a hydrogenation reactor that has a gas-distributing agitator functional to introduce and exhaust hydrogen gas and stir liquid reactant, so that hydrogen gas introduced into the hydrogenation reactor can be evenly distributed into a liquid reactant placed into the hydrogenation reactor to make the liquid reactant contain a high level of dissolved hydrogen, which not only enhances activity of an involved hydrogenation catalyst and accelerates hydrogenation reaction, but also allows hydrogenation reaction to be performed in a low-temperature, low-pressure environment. The hydrogenation process improve yield of the hydrogenated bisphenol-A-based epoxy resin to 99.0-99.9%, while significantly reducing building and maintaining costs for the hydrogenation reactor, thus being an economic process. |
| US08569437B2 |
Encapsulating material for solar cell
A solar cell encapsulated with an encapsulating material which is a non-crystalline or low-crystalline α-olefin-based copolymer or its composition (I). The composition (C) can contain 50 to 100 parts by weight of non-crystalline α-olefin polymer (A) which meets the following requirements: (a) the α-olefin having 3 to 20 carbon atoms is not less than 20 mol %, (b) practically no melt peak as measured by a differential scanning calorimeter is observed, and (c) the Mw/Mn is not more than 5, and 50 to 0 parts by weight of crystalline α-olefin polymer (B) (the total of (A) and (B) being 100 parts by weight). The non-crystalline or low-crystalline α-olefin copolymer may also have a crystallinity of not higher than 40% as measured by use of X rays. |
| US08569436B2 |
Polyvinyl chloride formulations
An extrudable polyvinyl chloride composition comprising from 80 to 99.9 percent by weight polyvinyl chloride for use in extruding a first part and a second part, wherein a fusion joint between the first extruded part and the second extruded part is formed by: A) composition at least a portion of a first terminal edge of the first extruded part and a first terminal edge of the second extruded part; B) engaging the melted terminal edges; and C) maintaining pressure between the engaged terminal edges to create a fused joint having a strength that is at least 50% of the tensile strength of the extruded part as measured by ASTM D638-2a. The extruded parts can be pipe sections. |
| US08569435B2 |
Amino acid mimetic copolymers and medical devices coated with the copolymers
Biocompatible polymers are manufactured to include an amino acid mimetic monomer and one or more hydrophobic acrylate monomers. The amino acid mimetic monomers are selected to mimic the side chain of the amino acids asparagine or glutamine. The amino acid mimetic monomer can be a methacryloyl or acryloyl derivative of 2-hydroxyacetamide, 3-hydroxypropionamide, alaninamide, lactamide, or glycinamide. These amide functional groups offer the advantage of moderate hydrophilicity with little chemical reactivity. The amino acid mimetic monomer can be copolymerized with one or more hydrophobic acrylate monomers to obtain desired coating properties. |
| US08569432B2 |
Semi-continuous method for emulsion polymerisation
A method for producing aqueous polymer dispersions by means of radically initiated emulsion polymerisation, in an aqueous medium, of vinyl ester and ethylene, in series-connected polymerisation reactors, wherein in a first discontinuous polymerisation phase at least some of the reactants are introduced into the first polymerisation reactor and the remainder is added in a metered fashion. The reactor is filled up to more than 90% by volume, and at least 90 wt % of the monomers are reacted; in a second continuous polymerisation phase, the reactants are continuously supplied to the first polymerisation reactor and product is continuously withdrawn, and the product is continuously transferred into a second polymerisation reactor, and in the second polymerisation reactor the polymerisation is continued until at least 98 wt % of the monomers used have reacted. |
| US08569428B2 |
High modulus polymer composites and methods of making the same
The invention provides methods of producing composite polymers by combining fillers with polymers in the presence of pre-formed high molecular weight polymer. Monomer polymerization can be initiated through the addition of initiators or by reactive chemical groups on the surface of the fibers. The composite materials formed possess superior mechanical properties compared to similar polymer composites made by either purely mechanical mixing or solely polymerization of monomers in the presence of the fillers. |
| US08569427B2 |
Polymers derived from rosin and their methods of preparation
Methods of forming polymer material from rosin-derived material are provided. For example, a plurality of functionalized resin acids having a polymerizable functional group via controlled living polymerization can be polymerized into the polymeric material such that each polymer defines a functional end group and the polymeric material has a polydispersity index of about 1 to about 1.5. The resulting polymers are also described. |
| US08569426B2 |
Preparation of polymer conjugates of therapeutic, agricultural, and food additive compounds
Disclosed is a process for preparing polymer conjugates of agricultural, therapeutic, and food additive compounds using Mitsunobu conditions. |
| US08569423B2 |
Triazine derivatives and a method for their production
The present invention relates to triazine derivatives of the general formula (I), their use and production. |
| US08569420B2 |
Singly-terminated polyisobutylenes and process for making same
The present invention generally relates to singly-terminated polyisobutylene (PIB) compounds, and to a process for making such compounds. In one embodiment, the present invention relates to singly-terminated polyisobutylene compounds that contain only one primary alcohol, amine, or methacrylate group as the single-terminating group. In another embodiment, the present invention relates to singly-terminated polyisobutylenes carrying exactly one terminal alcohol, amine, or methacrylate group, where such singly-terminated polyisobutylenes have a number average molecular weight of about 500 to about 5000 grams per mole. In still another embodiment, the present invention relates to singly-terminated polyisobutylene compounds that can be used to synthesize polyurethanes, to polyurethane compounds made via the use of such polyisobutylene compounds, and to processes for making such compounds. |
| US08569417B2 |
Modified polyolefins
The invention relates to a process for grafting hydrolysable silane groups to a polyolefin in which ethylene units, if present, form less than 50% by weight of the total polyolefin. The polyolefin is reacted with an unsaturated silane, having at least one hydrolysable group bonded to Si, or a hydrolysate thereof, in the presence of means capable of generating free radical sites in the polyolefin. The unsaturated silane has the formula R″—CH═CH—Z (I) or R″—C≡C—Z (II) in which Z represents an electron-withdrawing moiety substituted by a —SiRaR′(3-a) group wherein R represents a hydrolysable group; R′ represents a hydrocarbyl group having 1 to 6 carbon atoms; a has a value in the range 1 to 3 inclusive; and R″ represents hydrogen or a group having an electron withdrawing or any other activation effect with respect to the —CH═CH— or —C≡C— bond. The use of an unsaturated silane of the formula R″—CH═CH—Z (I) or R″—C≡C—Z (II) in carrying out the grafting reaction on the polyolefin may give enhanced grafting yield compared to grafting with an olefinically unsaturated silane such as vinyltrimethoxysilane not containing an electron withdrawing moiety Z. The invention permits to provide a silane-modified polyolefin having a high grafting efficiency while limiting/preventing polymer degradation by chain scission. The silane-modified polyolefin can be further reacted with a polar surface, a filler or a polar polymer or reacted on itself to crosslink the polyolefin and obtain enhanced physical properties of the composites made thereof. |
| US08569413B2 |
Aqueous coating composition
An aqueous coating composition having excellent coating adhesion, workability, heat resistance and chemical resistance, and has an object to provide an aqueous coating composition for sealing, which is suitable for members to be screwed in. An aqueous coating composition including: as main components, component (A) an ethylene-vinyl acetate copolymer resin emulsion and component (B) two or more PTFE resin powders having different particle diameters, in which 35 to 80 parts by mass of water is contained on the basis of 100 parts by mass of the total of (A) and (B). |
| US08569412B2 |
Heterophasic polypropylene copolymer composition
Heterophasic polypropylene composition comprising (A) 45 to 70 wt % of a propylene homo- or copolymer matrix with an MFR2 in accordance with ISO 1133 (230° C., 2.16 kg load) of ≧80 g/10 min and (B) 25 to 40 wt % of an elastomeric propylene-ethylene copolymer, having an intrinsic viscosity IV (ISO 1628, with decalin as solvent) of ≧3.3 dl/g and an ethylene content of 20 to 50 wt %, (C) 0-15 wt % of an elastomeric ethylene/alpha-olefin random copolymer (D) 3-25 parts per weight of inorganic filler, the heterophasic polypropylene compositions having a total MFR2 (230° C./2.16 kg) in accordance with ISO 1133 of ≧5 g/10 min, a Charpy notched impact strength according to ISO 179/1eA at +23° C. of ≧15.0 kJ/m2, preferably ≧25.0 kJ/m2, a minimum value for the Charpy notched impact strength according to ISO 179/1eA at −200 C of ≧7.0 kJ/m2, preferably ≧10.0 kJ/m2 and a tensile modulus according to ISO 527-3 of ≧1200 MPa; their preparation and use for producing injection molded articles being free of flow marks. |
| US08569409B2 |
Vulcanized elastomeric compositions
A vulcanized elastomeric composition includes (i) a polymer reaction product of an anionic elastomeric polymer and a silane-sulfide modifier and (ii) a second elastomeric polymer different from the polymer reaction product such that the polymer reaction product comprises at least 30 weight percent of a total amount of the polymer reaction product and the second elastomeric polymer. Methods are described for making the polymer reaction product, their use in preparing vulcanized elastomeric compositions, and articles made from such compositions, including pneumatic tires, tire treads, belts, and the like. |
| US08569407B2 |
Biodegradable material composed of a polymer comprising a porous metal-organic framework
The present invention relates to a biodegradable material in the form of a foil or a film, where the material comprises a polymer comprising at least one porous metal-organic framework and the at least one porous metal-organic framework comprises at least one at least bidentate organic compound coordinated to at least one metal ion. The invention further relates to food packaging comprising such a material and also its use for the packaging of foods and the use of a porous metal-organic framework for the absorption of ethene in food packaging. |
| US08569399B2 |
Polymeric compositions containing microspheres
Disclosed herein is a composition having a thermoset polymer and a plurality of hollow microsphere homogenously dispersed in the composition. The polymer is a cyanate ester thermoset, a phthalonitrile thermoset, a crosslinked acetylene thermoset, or a hydrosilation thermoset. Also disclosed herein is a method of: providing a thermosetting compound; adding microspheres to the thermosetting compound; and mixing the thermosetting compound while initiating crosslinking of the thermosetting compound. |
| US08569396B1 |
Antimicrobial coating having broad-range adhesion and thermoforming characteristics
Antimicrobial coatings with anti-staining properties that exhibit broad range adhesion characteristics are provided. The coating compositions comprise a mixture of water-borne resins that can be crosslinked through use of a suitable crosslinking agent. The coating compositions can be used on a variety of substrates and are highly flexible, thereby permitting their use on flexible and stretchable materials. Testing has shown the coatings to exhibit excellent antimicrobial characteristics against a broad class of particularly virulent pathogens. |
| US08569393B2 |
UV-LED curable compositions and inks
A radiation curable composition for UV LED curing includes at least one co-initiator selected from the group consisting of an aliphatic tertiary amine and a dialkyl aniline derivative; and at least one specific carbazole photoinitiator. The radiation curable composition can be advantageously used to prevent unstable yellowing behavior in an image upon storage. |
| US08569389B2 |
Organic/inorganic hybrid composite proton exchange membrane
An organic/inorganic hybrid composite proton exchange membrane is provided. The proton exchange membrane includes an inorganic material of about 0.5-30 parts by weight and an organic material of about 99.5-70 parts by weight per 100 parts by weight of the proton exchange membrane. A surface area of the inorganic material is about 50-3000 m2/g. The organic material includes a sulfonated polymer or a phosphoric acid doped polymer. |
| US08569386B2 |
Hydrocarbon synthesis reaction apparatus, hydrocarbon synthesis reaction system, and hydrocarbon synthesizing method
A hydrocarbon synthesis reaction apparatus which synthesizes a hydrocarbon compound by a chemical reaction of a synthesis gas including a hydrogen and a carbon monoxide as the main components, and a slurry having solid catalyst particles suspended in a liquid, the apparatus is provided with: a reactor in which the synthesis gas contacts with the slurry; and an unreacted gas supply device which draws unreacted gas from the reactor, then pressurizes the unreacted gas, and supplies the unreacted gas to a constituent device which constitutes the hydrocarbon synthesis reaction apparatus. |
| US08569385B2 |
Hydrolysis resistant organomodified silylated ionic surfactants
The present invention provides for a composition comprising a silane having the formula: (R1)(R2)(R3)Si—R4—Si(R5)(R6)(R7) wherein R1, R2, R3, R5, and R6 are each independently selected from the group consisting of 1 to 6 monovalent hydrocarbon radicals, aryl, and a hydrocarbon group of 7 to 10 carbons containing an aryl group; R4 is a hydrocarbon group of 1 to 3 carbons; R7 comprises an anionic, cationic or zwitterionic substituent. The silanes of the present invention exhibit resistance to hydrolysis over a wide pH range. |
| US08569384B2 |
Antimicrobial compositions
Antimicrobial compositions are provided that include a hydroalcoholic solvent system comprising a lower C2-C5 alcohol and water; a cationic antimicrobial agent such as chlorhexidine gluconate; a fatty component containing at least one free hydroxyl group, such as a C12-C21 fatty alcohol, a C12-C21 fatty ester, a C12-C21 fatty ether, a C12-C21 fatty amide, and combinations thereof; and optionally an emollient ester such as diesters of bibasic acids and trimesters of citric acid. The compositions described herein display improved antimicrobial efficacy and improved cosmetic elegance. Methods of using the antimicrobial compositions are provided. |
| US08569380B2 |
Oligomer-tricyclic conjugates
The invention provides small molecule drugs that are chemically modified by covalent attachment of a water soluble oligomer. A conjugate of the invention, when administered by any of a number of administration routes, exhibits characteristics that are different from the characteristics of the small molecule drug not attached to the water soluble oligomer. |
| US08569379B2 |
Use of rasagiline for the treatment of olfactory dysfunction
Disclosed are methods of treating olfactory dysfunction by periodically administering a therapeutically effective amount of rasagiline or a pharmaceutically acceptable salt of rasagiline to a subject. |
| US08569375B2 |
Compositions
An ingestible particulate composition comprises: a) at least one compound selected from the group consisting of 2,4-dichlorobenzyl alcohol, amylmetacresol, cetylpyridinium chloride, hexitidine, hexylresorcinol, flurbiprofen, lidocaine, benzocaine, ibuprofen, paracetamol, pectin, menthol, and benzydamine; and b) one or more bioadhesive materials. Resulting particulate compositions have excellent flow characteristics, dust suppression, organoleptic properties and stability. They are highly suitable for administration direction into a patient's mouth, and ingested to alleviate the symptoms of a sore throat. |
| US08569369B2 |
Amino acid compounds
A method for increasing the vasodilative characteristics of amino acids in a human or animal is disclosed. The method includes administering to the human or animal a pharmaceutically effective amount of an amino acid compound consisting essentially of a nitrate or nitrite of an amino acid selected from the group consisting of Aspartic Acid, Cysteine, Glycine, Lysine, Methionine, Proline, Tyrosine, Phenylalanine, Carnitine, Taurine, and Betaine. |
| US08569368B2 |
Amino acid compounds
Methods for increasing the bioabsorption of amino acids and for preventing the development of nitrate tolerances in a human or animal are disclosed. The methods include administering to the human or animal a pharmaceutically effective amount of an amino acid compound consisting essentially of a nitrate or nitrite of an amino acid selected from the group consisting of Aspartic Acid, Cysteine, Glycine, Lysine, Methionine, Proline, Tyrosine, Phenylalanine, Carnitine, Taurine, and Betaine. |
| US08569366B2 |
Acetyl L-carnitine for prevention of painful peripheral neuropathy in patients with type 2 diabetes
Acetyl L-carnitine, or of one of its pharmaceutically acceptable salts, is useful for the prevention of painful peripheral neuropathy in patients suffering from type 2 diabetes, in which symptoms are pain, paraesthesia or hyperaesthesia. The acetyl L-carnitine is administered orally at a dose of at least 3 grams/day. |
| US08569365B2 |
Compositions and methods for controlling infections
The invention features methods of inhibiting the growth of, or killing, fungal and certain bacterial microorganisms with one or more of a family of glycerol-based compounds. |
| US08569361B1 |
Aliphatic amino acid biosynthesis inhibitors and a method of synthesizing the same
The embodiments herein provide a composition and a method of synthesizing a composition comprising an aliphatic amino acid biosynthesis inhibitor having an antifungal activity. The composition comprises 2-oxo-2H-chromen-7-yl propiolate, diethyl-hex-2-en-4-yne-dioate and dinonyl-hex-2-en-4-yne-dioate. The composition inhibits a biosynthesis of an aliphatic amino acid in a fungal biological system. The aliphatic amino acid is selected from a group consisting of leucine, isoleucine and valine. The composition is used with a concentration of 0-200 μg/ml. The method comprises mixing solutions of dicyclohexylcarbodiimide (DCC) and Dimethylaminopyridine (DMAP) with alcohol, acetylene carboxylic acid and dichloromethane to obtain a mixture which is stirred filtered and washed with ether. The solvents are evaporated to obtain a residue that is dissolved in dichloromethane and stirred with a catalyst. The extra solvents are evaporated to obtain the derivative compound and purified by silica gel column chromatography. |
| US08569360B2 |
Compositions and methods for inhibition of hepatocyte growth factor receptor c-Met signaling
Derivatives and analogs of inhibitors of receptor tyrosine kinase c-Met obtained by virtual screening, pharmaceutical compositions containing derivatives and analogs of c-Met inhibitors are provided. Methods of making derivatives and analogs of c-Met inhibitors and methods of use thereof are provided. Formula (I) |
| US08569358B2 |
Use of silymarin and/or constituents thereof as skin or hair pigmentation promoters
Describe is a method of administering to a subject silymarin, or of the main constituents thereof alone or as a mixture, chosen from silybin (or 2,3-dihydro-3-(4-hydroxy-3-methoxyphenyl)-2-(hydroxymethyl)-6-(3, 5,7-trihydroxy-4-oxobenzopyran-2-yl)benzodioxine), isosilybin, silydianin, silychristin, silandrin, silymonin and taxifolin, isolated enantiomers thereof and also salts thereof. |
| US08569357B2 |
Taxane pro-emulsion formulations and methods making and using the same
Taxane pro-emulsion formulations are provided. Pro-emulsion formulations are dried powders that include a taxane, oil, surfactant and sugar alcohol. Also provided are methods of making and using the pro-emulsion formulations, as well as kits that include the pro-emulsion formulations. |
| US08569356B2 |
Cyclin dependent kinase inhibitors
The invention relates to cyclin dependent kinase inhibitor compounds and methods of identifying and using them. The invention further relates to pharmaceutical compositions for treating cell proliferative disorders, especially cancer. |
| US08569352B2 |
Imidazole based LXR modulators
Compounds of the invention, such as compounds of Formulae IIa, IIb, IIc or IId, and pharmaceutically acceptable salts, isomers, and prodrugs thereof, are useful as modulators of the activity of liver X receptors, where R1, R2, R21, R3 and G are defined herein. Pharmaceutical compositions containing the compounds and methods of using the compounds are also disclosed. |
| US08569351B2 |
Dual-acting benzyl triazole antihypertensive agents having angiotensin II type receptor antagonist activity and neprilysin-inhibition activity
The invention is directed to compounds having the formula: wherein: Ar, X, R3, and R5-7 are as defined in the specification, and pharmaceutically acceptable salts thereof. These compounds have AT1 receptor antagonist activity and neprilysin inhibition activity. The invention is also directed to pharmaceutical compositions comprising such compounds; methods of using such compounds; and process and intermediates for preparing such compounds. |
| US08569350B2 |
Anti-mitotic anti-proliferative compounds
Substituted triazole compounds and pharmaceutical compositions thereof are presented. Also presented are methods for treating a pathology linked to a hyperproliferative disorder by administering the substituted triazole compounds to a patient in need thereof. |
| US08569348B2 |
Compounds, compositions, and methods for preventing metastasis of cancer cells
Disclosed are methods for preventing metastasis of cancer cells. The disclosed compounds can be used to prevent the spread of tumor or other types of cancer cells. |
| US08569342B2 |
Diastereomers of 4-aryloxy-3-hydroxypiperidines
The present invention relates to essentially pure diastereomers of 4-aryloxy-3-hydroxypiperidines, including purified diastereomers of ifoxetine, methods of purifying said diastereomers, pharmaceutical compositions comprising said diastereomers and methods of treatment utilizing said pharmaceutical compositions. |
| US08569338B2 |
Methods of using 4, 5, 6, 7-tetrahydroimidazo-[4,5-c]pyridine compounds
The present invention relates to a method for the treatment or prevention of inflammation, an inflammatory disease, an immune or an autoimmune disorder, which comprises administering to a mammal in need of such treatment an effective amount of a compound compound of formula (I), and their pharmaceutically acceptable salts, solvates, hydrates, geometrical isomers, tautomers, optical isomers or N-oxides, which are inhibitors of SSAO activity. |
| US08569337B2 |
Tri-cyclic pyrazolopyridine kinase inhibitors
The present invention relates to compounds of tri-cyclic pyrazolopyridine useful as inhibitors of protein kinase. The invention also provides pharmaceutically acceptable compositions containing such compounds and methods of using the compositions in the treatment of various disease, conditions, or disorders. The invention also provides processes for preparing compounds of the inventions. |
| US08569336B2 |
Compounds for the treatment of inflammatory disorders
This invention relates to compounds of the Formula (I): (Chemical formula should be inserted here as it appears on abstract in paper form) (I) or a pharmaceutically acceptable salt thereof, which can be useful for the treatment of diseases or conditions mediated by MMPs, ADAMs, TACE, aggrecanase, TNF- or combinations thereof. |
| US08569330B1 |
Opioid salts and formulations exhibiting anti-abuse and anti-dose dumping properties
A drug substance with a pharmaceutically acceptable organic acid addition salt of an opioid wherein said organic acid is selected from Structure A: wherein R1-R4 are independently selected from H, alkyl or substituted alkyl of 1-6 carbons, adjacent groups may be taken together to form a cyclic alkyl, cyclic alkyl-aryl, or cyclic aryl moiety; R5 is selected from H, or an alkali earth cation; R6 and R7 are independently selected from H, alkyl of 1-6 carbons, an alkali earth cation, and aryl of 6 to 12 carbons, in a number sufficient to complete the valence bonding of X, and wherein X is selected from nitrogen, oxygen or sulfur; and wherein the drug substance has a morphology selected from amorphous and crystalline. |
| US08569327B2 |
Phenanthroindolizidine derivative and NFκB inhibitor containing same as active ingredient
A novel compound having an excellent NFκB inhibitory effect is provided. Specifically disclosed is a compound represented by the following formula (1) or a salt thereof: wherein, R1 represents a hydrogen atom, a lower alkyl group, or the like; R2 represents a hydrogen atom, a lower alkyl group, a halogen atom, or the like; R3 represents a hydrogen atom, a lower alkyl group, a hydroxyl group, or a halogen atom; R4 represents a hydrogen atom or a lower alkyloxy group; R5 represents a hydrogen atom, a lower alkyloxy group, a halogen atom, a hydroxyl group, or a methylenedioxy group formed together with R6 or an isopropylidenedioxy group formed together with R6; R6 represents a hydrogen atom, a lower alkyloxy group, or a methylenedioxy group formed together with R5 or an isopropylidenedioxy group formed together with R5; R7 represents a hydrogen atom or a lower alkyl group; and R8 represents a hydrogen atom, a hydroxyl group, an amino group, a lower alkylcarbonyloxy group, or a halogen atom. |
| US08569326B2 |
Forms of rifaximin and uses thereof
The present invention relates to Rifaximin polymorphic forms, to their use in medicinal preparations and to therapeutic methods using them. |
| US08569325B2 |
Method of treatment with coadministration of aspirin and prasugrel
A method for the prevention of diseases caused by thrombus or embolus. The method is to separately administer 2-acetoxy-5-(α-cyclopropylcarbonyl-2-fluorobenzyl)-4,5,6,7-tetrahydrothieno[3,2-c]pyridine or a pharmaceutically acceptable salt thereof, and aspirin, in their pharmacologically effective amounts, to a warm-blooded animal. |
| US08569323B2 |
Substituted isoquinolin-1(2H)-one compounds, compositions, and methods thereof
Chemical entities that modulate PI3 kinase activity, pharmaceutical compositions containing the chemical entities, and methods of using these chemical entities for treating diseases and conditions associated with PI3 kinase activity are described herein. |
| US08569322B2 |
Lamivudine oxalate and preparation method thereof
Lamivudine oxalate, preparation method and crystalline forms thereof are disclosed. A preparation method of Lamivudine is also disclosed. |
| US08569318B2 |
Tetrahydro-pyrazolo[1,5-a]pyrido-pyrimidines as antagonists of serotonin 5-HT6 receptors, methods for the production and use thereof
The present invention relates to serotonin 5-HT6 receptor antagonists-novel substituted 3-sulfonyl-6,7,8,9-tetrahydropyrazolo[1,5-a]pyrido[4,3-e]pyrimidines and substituted 3-sulfonyl-5,6,7,8-tetrahydropyrazolo[1,5-a]pyrido[4,3-d]pyrimidines, drug substances and pharmaceutical compositions comprising drug substances as the mentioned above compounds and to the method of prophylaxis and treatment of various conditions and diseases of central nervous system in humans and warm-blooded animals pathogenesis of which is associated with serotonin 5-HT6 receptors.In formulas 1 and 2 Ar is optionally substituted aryl or optionally substituted heterocyclyl; R1 is hydrogen, optionally substituted lower C1-C3 alkyl, substituted hydroxyl group, substituted sulfanyl group; R2 is hydrogen or optionally substituted C1-C3 alkyl; R3 is hydrogen, optionally substituted C1-C3 alkyl or tert.-butyloxycarbonyl. |
| US08569316B2 |
Pyrimido [5,4-D] pyrimidine derivatives for the inhibition of tyrosine kinases
The present invention encompasses compounds of general formula (1), wherein the groups R1 to R4, X1, X2, X3, X4, X5, Q, L1 and L2 are defined as in claim 1, which are suitable for the treatment of diseases characterised by excessive or abnormal cell proliferation, as well as pharmaceutical preparations and formulations of these compounds. |
| US08569313B2 |
Meta-substituted phenyl sulfonyl amides of secondary amino acid amides, the production thereof, and use thereof as matriptase inhibitors
The invention relates to meta-substituted phenyl sulfonyl amides of secondary amino acid amides according to the general formula (I), (II), or (III), the production thereof, and the use thereof as matriptase inhibitors, in particular the use thereof as drugs for inhibiting tumor growth and/or metastasization. |
| US08569312B2 |
Biaryl-spiroaminooxzaoline analogues as alpha 2C adrenergic receptor modulators
In its many embodiments, the present invention provides a novel class of biaryl spiroaminooxazoline analogues as modulators of α2C adrenergic receptor agonists, methods of preparing such compounds, pharmaceutical compositions containing one or more such compounds, methods of preparing pharmaceutical formulations comprising one or more such compounds, and methods of treatment, prevention, inhibition, or amelioration of one or more conditions associated with the α2C adrenergic receptors using such compounds or pharmaceutical compositions. |
| US08569310B2 |
Pentafluorosulfur imino heterocyclic compounds as BACE-1 inhibitors, compositions and their use
In its many embodiments, the present invention provides certain pentafluorosulfur imino heterocyclic compounds, including compounds Formula (a) and pharmaceutically acceptable salts thereof. Compounds of Formula (a) have the general structure: (a) wherein each variable is selected independently and as defined herein. Pharmaceutical compositions comprising one or more such compounds (alone and in combination with one or more other active agents), and methods for their preparation and use in treating pathologies associated with amyloid beta (Aβ) protein, including Alzheimers Disease, are also disclosed. |
| US08569309B2 |
4′-demethylepipodophyllotoxin derivative, preparation method and use thereof
A 4′-demethylepipodophyllotoxin derivative of formula(III) having anti-tumor activity is provided. After the activation of hydroxyl in position C4 of 4′-demethylepipodophyllotoxin, tetramethylpyrazine is introduced by transamination to obtain the 4′-demethylepipodophyllotoxin derivative which is preferably used to inhibit gastric cancer line BGC-823. |
| US08569303B2 |
Diamine derivatives as inhibitors of leukotriene A4 hydrolase
This invention is directed to compounds of formula (I): where r, q, R, R2, R3, R4, R5a, R5b, R5c, R6a, R6b, R6c, R7, R8, and R9 are described herein, as single stereoisomers or as mixtures of stereoisomers, or pharmaceutically acceptable salts, solvates, clathrates, polymorphs, ammonium ions, N-oxides or prodrugs thereof; which are leukotriene A4 hydrolase inhibitors and therefore useful in treating inflammatory disorders. Pharmaceutical compositions comprising the compounds of the invention and methods of preparing the compounds of the invention are also disclosed. |
| US08569302B2 |
Inhibitors of flaviviridae viruses
Provided are compounds of Formula I: and pharmaceutically acceptable salts and esters thereof. The compounds, compositions, and methods provided are useful for the treatment of Flaviviridae virus infections, particularly hepatitis C infections. |
| US08569301B2 |
6, 6-dioxo-6-thia-1, 4-diaza-naphthalenes as herbicides
The present invention relates to 6,6-dioxo-6-thia-1,4-diaza-naphthalene derivatives of formula (I) where R1, R2, R3a, R3b, R4 and R5 are as defined in claim 1; or a salt or N-oxide thereof. Furthermore, the present invention relates to processes and intermediates for making compounds of formula (I), to herbicidal compositions comprising compounds of formula (I) and to methods of using compounds of formula (I) to control plant growth. |
| US08569300B2 |
Substituted tetrazolo[1,5-A]pyrazine inhibitors of histamine receptors for the treatment of disease
The present invention relates to substituted tetrazolo[1,5-a]pyrazine compounds for Formula IX: as well as pharmaceutical compositions thereof, which may be useful as inhibitors of H4R for the treatment or prevention of inflammatory, autoimmune, allergic, and ocular diseases. |
| US08569298B2 |
Pyridine compounds
The present invention relates to compounds that inhibit of focal adhesion kinase function, processes for their preparation, pharmaceutical compositions containing them as the active ingredient, to their use as medicaments and to their use in the manufacture of medicaments for use in the treatment in warm-blooded animals such as humans of diseases such as cancer. |
| US08569297B2 |
1-benzyl-3-hydroxymethylindazole derivatives and use thereof in the treatment of diseases based on the expression of MCP-1 and CX3CR1
The present invention relates to novel 1-benzyl-3-hydroxymethylindazole derivatives according to formula (I) described in the claims, and to a pharmaceutical composition comprising them, together with a pharmaceutically acceptable vehicle. In addition, the present invention relates to the use of novel 1-benzyl-3-hydroxymethylindazole derivatives for the preparation of a pharmaceutical composition that is active in the treatment of diseases based on the expression of MCP-1 and CX3CR1, and to their use in a method for treating or preventing diseases based on the expression of MCP-1 and CX3CR1. |
| US08569294B2 |
2-(cyclic amino)-pyrimidone derivatives
A compound represented by the formula (I), an optically active isomer thereof, or a pharmaceutical acceptable salt thereof: wherein R2 represents a hydrogen or the like; R3 represents methyl group or the like; R20 represents a halogen atom or the like; q represents an integer of 0 to 3; Z represent nitrogen atom, CH, or the like; R4 represents hydrogen or the like; R5 represents hydrogen or the like; R6 represents a substituted alkyloxy and the like; p represents an integer of 0 to 3; X represents bond, CH2, oxygen atom, NH, or the like; any one or more of R5 and R6, R5 and R4, R6 and R4, X and R5, X and R4, X and R6, and R6 and R6 may combine to each other to form a ring, which is used for preventive and/or therapeutic treatment of a disease caused by tau protein kinase 1 hyperactivity such as a neurodegenerative diseases (e.g. Alzheimer disease). |
| US08569292B2 |
Cyclic inhibitors of 11β-hydroxysteroid dehydrogenase 1
This invention relates to novel compounds of the Formula I, Ik, Iq1-21, Ir1-21, Is1-21, It1-7, pharmaceutically acceptable salts thereof, and pharmaceutical compositions thereof, which are useful for the therapeutic treatment of diseases associated with the modulation or inhibition of 11 β-HSD1 in mammals. The invention further relates to pharmaceutical compositions of the novel compounds and methods for their use in the reduction or control of the production of cortisol in a cell or the inhibition of the conversion of cortisone to cortisol in a cell. |
| US08569282B2 |
Carboxamide compounds and their use
Chemokine receptor antagonists, in particular, compounds of Formula (I-A) that act as antagonists of the chemokine CCR2 receptor, including pharmaceutical compositions and uses thereof to treat or prevent diseases associated with monocyte accumulation, lymphocyte accumulation or leukocyte accumulation are described herein. |
| US08569280B2 |
Methods for the treatment of multiple myeloma
Methods for treating multiple myeloma with inhibitors of CXCR4, such as AMD3100 and anti-CXCR4 antibodies, are described. The decreased expression of CXCR4 on multiple myeloma cells according to the invention results in decreased homing of the cells to the bone marrow and a reduction in the development of the disease. Also disclosed are pharmaceutical compositions incorporating such inhibitors for use in the therapeutic treatment of multiple myeloma. The treatment methods described herein can be used independently, or in conjunction with, other therapies for the treatment of multiple myeloma. |
| US08569278B2 |
Anti-histamine compositions and use thereof
The present invention provides for a storage stable pharmaceutical liquid solution for oral administration having a pharmaceutically effective amount of an antihistamine and having a purity equal to or greater than about 99% by weight-based HPLC assay, residual solvents of less than about 0.5%, and a total impurity of less than about 0.2%. The storage stable solution preferably contains cetirizine. The present invention further provides a process of preparing the storage stable pharmaceutical liquid solution as well as a method of treating a mammal with a therapeutically effective amount of cetirizine in the stable pharmaceutical liquid solution. |
| US08569277B2 |
Methods of treating a subject for a condition
Methods are provided for treating a subject for at least one condition that includes inflammation, a blood clotting condition and autonomic nervous system dysfunction such as adrenergia, e.g., simultaneously. Also provided are kits for use in practicing the subject methods. |
| US08569276B2 |
Structural modification of 19-norprogesterone I: 17-α-substituted-11-β-substituted-4-aryl and 21-substituted 19-norpregnadienedione as new antiprogestational agents
The present invention relates, inter alia, to compounds having the general formula: in which R1, R2, R3, R4 and X are as defined by the present specification. In addition to providing the compounds of Formula I, the present invention provides methods wherein the compounds of Formula I are advantageously used, inter alia, to antagonize endogenous progesterone; to induce menses; to treat endometriosis; to treat dysmenorrhea; to treat endocrine hormone-dependent tumors; to treat meningiomas; to treat uterine leiomyomas; to treat uterine fibroids; to inhibit uterine endometrial proliferation; to induce cervical ripening; to induce labor; and for contraception. |
| US08569272B2 |
Methods for treating a posterior segment of an eye
Compositions, and methods of using such compositions, useful for injection into the posterior segments of human or animal eyes are provided. Such compositions include corticosteroid component-containing particles present in a therapeutically effective amount, a viscosity inducing component, and an aqueous carrier component. The compositions have viscosities of at least about 10 cps or about 100 cps at a shear rate of 0.1/second. In a preferred embodiment, the viscosity is in the range of from about 140,000 cps to about 300,000 cps. The compositions advantageously suspend the particles for prolonged periods of time. |
| US08569269B1 |
Chirally correct retinal cyclodextrin hemiacetals for treating skin disorder
The present invention discloses a method of treating, reducing the occurrence of, or improving the symptoms associated with a skin condition by topical application of a compound of formula (I) or a salt thereof, wherein said skin condition is selected from the group consisting of melanogenesis, oxidative damage, inflammation, skin irritation from inflammation, loss of cell adhesion, loss of desquamation, extra-cellular including connective tissue matrix breakdown and skin tone loss thereof, loss of keratinization, cellular senescence, skin aging from cellular senescence, loss of skin whiteness, loss of skin barrier function, loss of skin firmness, rosacea, skin wrinkles and fine lines from cellular senescence, cellular oxidation, loss of skin collagen, topical wounds, and combinations thereof. |
| US08569265B2 |
Deuterated analogs of (4S)-4-ethyl-4-hydroxy-11-[2- (trimethylsilyl)ethyl]-1H-pyrano[3′, 4′:6,7] indolizino [1,2-b]quinoline-3,14(4H, 12H)-dione and methods of use thereof
The present invention discloses: (i) two novel deuterated Karenitecin® analogs, pharmaceutically-acceptable salts, and/or derivatives thereof; (ii) methods of synthesis of said novel deuterated Karenitecin® analogs, pharmaceutically-acceptable salts, and/or derivatives thereof; (iii) pharmaceutically-acceptable formulations comprising said novel deuterated Karenitecin® analogs, pharmaceutically-acceptable salts, derivatives thereof; and/or, optionally, one or more additional chemotherapeutic agents; and (iv) methods of administration of said novel deuterated Karenitecin® analogs, pharmaceutically-acceptable salts, derivatives thereof; and/or, optionally, one or more additional chemotherapeutic agents, to subjects in need thereof. |
| US08569263B2 |
Method of producing silane-modified cationized cellulose
A method of producing silane-modified cationized cellulose that has excellent aqueous dispersibility, including: a step (1) of cationizing water-soluble cellulose ether in a presence of alkali in a mixed solvent of a water-compatible organic solvent to obtain slurry comprising cationized cellulose; a step (2) of adding acid to said slurry and neutralizing said alkali; a step (3) of reacting said cationized cellulose obtained after said neutralization with an aminosilane compound and a step (4) of drying the obtained slurry, wherein: drying is conducted in step (4) at 115-160° C. until weight loss on drying is 5% by weight or less, or there is also including a step (5) of adding a water-compatible organic solvent or a mixed solvent of a water-compatible organic solvent and water to the cationized cellulose after the neutralization so that water content in a whole solvent that contacts the cationized cellulose is 10% by mass or less. |
| US08569260B2 |
N-pyrazole A2A receptor agonists
The present disclosure provides a process for the preparation of 2-adenosine N-pyrazole compounds exemplified by the structure shown below that are potent and selective agonists for A2A adenosine receptor, compositions comprising these compounds, and methods for using these compounds to stimulate mammalian coronary vasodilation for imaging the heart. |
| US08569259B2 |
Adenosine analogs and their use
Provided are adenosine analog compounds of the general formula that act as P2Y receptors, e.g., the P2Y2 receptor, including pharmaceutical compositions; and uses thereof to treat or prevent diseases associated with that receptor, e.g., disorders relating to mucus secretion, such as cystic fibrosis, chronic obstructive pulmonary disorder (COPD), asthma, constipation, chronic idiopathic constipation, dry mouth (xerostomia), gum disease, and gastrointestinal problems caused by radiation and chemotherapy for cancer. |
| US08569257B2 |
Method for modulating responsiveness to steroids
A method for enhancing steroid efficacy in a steroid refractory patient afflicted with an inflammatory condition not responding or responding poorly or inadequately to anti-inflammatory treatment comprises administering an oligonucleotide having the sequence formula (SEQ. ID. No. 18) 5′-Xm-TTCGT-Yn-3′ in an effective amount to said patient and wherein X is A, T, C or G, Y is A, T, C or G, m=0-7, n=0-7 and wherein at least one CG dinucleotide is unmethylated. |
| US08569256B2 |
Cationic lipids and methods for the delivery of therapeutic agents
The present invention provides compositions and methods for the delivery of therapeutic agents to cells. In particular, these include novel cationic lipids and nucleic acid-lipid particles that provide efficient encapsulation of nucleic acids and efficient delivery of the encapsulated nucleic acid to cells in vivo. The compositions of the present invention are highly potent, thereby allowing effective knock-down of a specific target protein at relatively low doses. In addition, the compositions and methods of the present invention are less toxic and provide a greater therapeutic index compared to compositions and methods previously known in the art. |
| US08569251B2 |
Use of microwave irradiation for delivery of macromolecules
The present invention is directed to methods of delivering macromolecules to a target cell or tissue by microwave irradiation. A target cell or tissue is exposed to one or more macromolecules to be delivered into the desired cell or tissue and irradiated with microwave radiation. The strength or power of the microwave radiation is such that the macromolecules are delivered into the target cell or tissue. Preferably, the strength of the microwave radiation does not significantly impact cell viability in a negative manner (e.g., apoptosis). |
| US08569250B2 |
Organic compounds
A method of inhibiting dipeptidyl peptidase-IV comprising administering to a mammal in need of such treatment a therapeutically effective amount of a compound of formulae (I A), (I B), (X A), (X B), (Y A) or (Y or B),wherein R′ represents and R″ represents hydrogen, hydroxy, C1-C7alkoxy, C1-C8-alkanoyloxy, or R5R4N—CO—O—, where R4 and R5 independently are C1-C7alkyl or phenyl which is unsubstituted or substituted by a substitutent selected from C1-C7alkyl, C1-C7alkoxy, halogen and trifluoromethyl and where R4 additionally is hydrogen; or R4 and R5 together represent C3-C6alkylene, in free form or in form of a pharmaceutically acceptable acid addition salt. |
| US08569247B2 |
Hydrolysate of crocin
The present invention relates to a composition derived from the hydrolysate of plant containing crocin or the derivatives thereof. The composition includes a significant amount of crocetin monoester. The present invention also provides a method to hydrolyze crocin existing in a plant extract, and further relates to the use. |
| US08569246B2 |
Agonists of guanylate cyclase useful for the treatment of gastrointestinal disorders, inflammation, cancer and other disorders
The invention provides novel guanylate cyclase-C agonist peptides and their use in the treatment of human diseases including gastrointestinal disorders, inflammation or cancer (e.g., a gastrointestinal cancer). The peptides can be administered either alone or in combination with an inhibitor of cGMP-dependent phosphodiesterase. The gastrointestinal disorder may be classified as either irritable bowel syndrome, constipation, or excessive acidity etc. The gastrointestinal disease may be classified as either inflammatory bowel disease or other GI condition including Crohn's disease and ulcerative colitis, and cancer. |
| US08569242B2 |
Method of treating degenerative disorders of the nervous system
The invention herein related to methods and compositions for treating nervous system disorders. The methods comprise administration of antibodies directed towards peptides that bind to receptors important in disease progression, thus attenuating the disease. |
| US08569241B2 |
Composition for improving brain function and method for improving brain function
Provided are a composition for improving the brain function, which can be orally taken at a low dose, and a method therefor. The composition for improving the brain function contains, as the active ingredient, X-Pro-Pro-Leu-Thr-Gln-Thr-Pro-Val-Val-Val-Pro-Pro-Phe-Leu-Gln-Pro-Glu-Y (wherein X is nil or represents Ile or Asn-Ile; and Y is nil or represents Val-Met), X-Val-Val-Val-Pro-Pro-Phe-Leu-Gln-Pro-Glu-Y (wherein X is abscent or represents Thr-Gln-Thr-Pro, Pro-Leu-Thr-Gln-Thr-Pro, Leu-Thr-Gln-Thr-Pro or Pro; and Y is abscent or represents Val-Met), or a salt of the same. The method for improving the brain function comprises administering said peptide or a salt of the same. |
| US08569237B2 |
Chimeric hirudin proteins
The present invention relates to a chimeric hirudin protein comprising a carrier attached to the N-terminus of hirudin, with an intervening plasmin cleavage site. The chimeric hirudin protein contains a relatively inactive form of hirudin. However, when such chimeric hirudin protein being cleaved by plasmin in the vicinity of a clot and, ultimately causing the release of active hirudin and the reduction of the size of the clot. The chimeric hirudin protein exhibited much slower clearance in mice than unfused wild-type hirudin. |
| US08569236B2 |
Resuscitation fluid
A method for treating conditions related to lack of blood supply with a lipid based resuscitation fluid is disclosed. The resuscitation fluid contains a lipid component and an aqueous carrier. The lipid component forms an emulsion with the aqueous carrier. The resuscitation fluid can be used to increase the blood pressure and to carry oxygen to tissues. The resuscitation fluid can also be used for preserving the biological integrity of donor organs for transplantation. |
| US08569233B2 |
Modified animal erythropoietin polypeptides and their uses
Modified animal erythropoietin polypeptides and uses thereof are provide. |
| US08569228B2 |
Compositions comprising enzyme-cleavable oxycodone prodrug
The embodiments provide Compound KC-8, N-1-[3-(oxycodone-6-enol-carbonyl-methyl-amino) -2,2-dimethyl-propylamine]-arginine-glycine-malonic acid, or acceptable salts, solvates, and hydrates thereof. The present disclosure also provides compositions, and their methods of use, where the compositions comprise a prodrug, Compound KC-8, that provides controlled release of oxycodone. Such compositions can optionally provide a trypsin inhibitor that interacts with the enzyme that mediates the controlled release of oxycodone from the prodrug so as to attenuate enzymatic cleavage of the prodrug. |
| US08569227B2 |
Stabilized fibronectin domain compositions, methods and uses
A protein scaffold based on a consensus sequence of fibronectin type III (FN3) proteins, such as the tenth FN3 repeat from human fibronectin (human Tenascin), including isolated nucleic acids that encode a protein scaffold, vectors, host cells, and methods of making and using thereof, exhibit enhanced thermal and chemical stability while presenting six modifiable loop domains which can be engineered to form a binding partner capable of binding to a target for applications in diagnostic and/or therapeutic compositions, methods and devices. |
| US08569224B2 |
Fabric softener active composition
A fabric softener active composition, comprising at least 50% by weight of a bis-(2-hydroxypropyl)-dimethylammonium methylsulphate fatty acid ester having a molar ratio of fatty acid moieties to amine moieties of from 1.5 to 1.99, wherein the average chain length of the fatty acid moieties is from 16 to 18 carbon atoms and the iodine value of the fatty acid moieties, calculated for the free fatty acid, is from 0.5 to 50, and from 0.5 to 5% by weight fatty acid provides high softening performance and good storage stability in aqueous dispersion and can be handled and processed in a liquid state without addition of a flammable solvent. |
| US08569222B2 |
Laundry article having cleaning properties
A laundry article used for cleaning fabrics includes a water-insoluble nonwoven substrate and coated thereon into at least one zone each a detergent composition and an enzyme-containing composition. The enzyme-containing composition comprises an enzyme embedded in a matrix. |
| US08569219B2 |
High alcohol content foaming compositions comprising an anionic phosphate fluorosurfactant
A “high lower alcohol content” (>40% v/v of a C1-4 alcohol) liquid composition is able to be dispensed as a stable foam with the use of non-propellant foam dispensing devices from non-pressurized containers. The liquid compositions comprise an alcohol, C1-4 (>40% v/v), a fluorosurfactant of at least 0.001% by weight to prepare a foamable composition, 0-10% w/w of additional minor components added to obtain the desired performance (a foamable composition with a viscosity less than 4,000 cps), and the balance being purified water. The compositions may include emulsifier-emollients and moisturizers, secondary surfactants, foam stabilizers, fragrances, antimicrobial agents, other type of medicinal ingredients, and the like ingredients or additives or combinations thereof commonly added to alcohol gels or foams, aerosol compositions or to toiletries, cosmetics, pharmaceuticals and the like. |
| US08569217B2 |
Lubricating composition containing a carboxylic functionalised polymer and dispersant
The invention provides an oil of lubricating viscosity, a dispersant and an amine-functionalised additive, wherein the amine-functionalised additive is derived from an amine having at least 3 or 4 aromatic groups. The invention further relates to the use of the lubricating composition in an internal combustion engine. |
| US08569216B2 |
Lubricant formulation with high oxidation performance
A Group IV/Group V lubricating composition providing improved antioxidation performance comprises from 5 wt. % to 40 wt. % of a Group V base oil component, such as alkylated naphthalene, at least 30 wt. % of a Group IV base oil component, such as one or more polyalphaolefin base stocks, and from 0.25 wt. % to 1.5 wt. % of a trithiophosphate-containing compound. The trithiophosphate-containing compound is preferably C30H57O7PS3. The lubricating composition includes not greater than 5 wt. % of a Group I, Group II, or Group III base oil component, and, preferably not greater than 10 ppm heavy metal component. The lubricating composition preferably has a kinematic viscosity of from 20 cSt to 1,000 cSt at 40° C. and a viscosity index (VI) of from 130 to 200. |
| US08569213B2 |
Drilling fluids having reduced sag potential and related methods
Invert emulsion drilling fluids that have extended emulsion stability and reduced sag potential can be realized through incorporation of colloidal particles therein. The invert emulsion drilling fluids can be free of organophilic clays. The organophilic clay-free drilling fluids can comprise: an oleaginous fluid continuous phase; an aqueous fluid internal phase; a surfactant; a weighting agent; and a plurality of colloidal particles, the colloidal particles comprising fibrous colloidal particles and at least one other type of colloidal particle; wherein at least a portion of the plurality of colloidal particles interact with the surfactant to form an associative supporting structure that inhibits sag of the weighting agent. |
| US08569210B2 |
Turfgrass fungicide formulation with pigment
Oil-in-water fungicidal formulations are prepared having pigment dispersed therein, the pigment being stable within the oil-in-water emulsion as a result of the addition of suitable silicone surfactants and suitable emulsifiers. The formulations can be prepared either as a 2-pack formulation or as a single formulation. In the case of the single formulation polyethylene glycol is also added. In either case, the formulations show a synergistic effect through the addition of the pigment, the resulting formulations having an increased efficacy. Further, the formulations show a synergistic effect when mixed with conventional chemical fungicides, both being added in reduced amounts compared to recommended rates. |
| US08569209B2 |
Thickener for plant-compatible concentrates that can be dispersed in water
The present invention relates to novel water-dispersed agrochemical formulations, for example water-based suspension concentrates, of active agrochemical ingredients, comprising a penetrant and a thickener from the class of the anionic polysaccharides which contains, as the repetitive base unit in the main chain, four sugar molecules (glucose, glucuronic acid, glucose, rhamnose), to a process for producing these formulations and to the use thereof for application of the active ingredients present. |
| US08569205B2 |
Media for removal of contaminants from fluid streams and method of making same
Sorption media for removal of contaminants from fluid streams are provided. The sorption media comprise an active compound bound or linked to a support substrate or matrix. Support substrates can include iron- and alumina-based materials. A method for making sorption media for the removal of contaminants from fluid streams is also described. The method includes selecting a support substrate, and, optionally, providing a doping mixture comprising an active compound. The selected support substrate can be contacted with the doping mixture to form a doped mixture. The doped mixture can be reacted at a predetermined temperature and atmospheric environment for a predetermined duration to form an active media, wherein the active compound is bound or linked to the support substrate. |
| US08569201B2 |
Exhaust gas purifying catalyst and method for manufacturing the same
An exhaust gas purifying catalyst includes: rhodium; a zirconium-containing oxide which supports rhodium, and comprises: at least one element selected from the group consisting of calcium, lanthanum, cerium, neodymium and yttrium; and zirconium; and a NOx absorbing material comprising at least one selected from the group consisting of magnesium, barium, sodium, potassium and cesium. A degree of dispersion of rhodium is 20% or more after baking at 900° C. in air for three hours. A method for manufacturing the exhaust gas purifying catalyst includes: mixing the zirconium-containing oxide with water, thereby preparing an aqueous liquid of the zirconium-containing oxide; and supporting rhodium on the zirconium-containing oxide by mixing the aqueous liquid of the zirconium-containing oxide with an aqueous solution of a rhodium salt. A pH of a mixed liquid of the aqueous solution of the rhodium salt and the aqueous liquid of the zirconium-containing oxide is adjusted to 7 or more. |
| US08569200B2 |
Catalyst for hydrocarbon steam cracking, method of preparing the same and method of preparing olefin by using the same
A catalyst for hydrocarbon steam cracking for the production of light olefin, a preparation method of the catalyst and a preparation method of olefin by using the same. More precisely, the present invention relates to a composite catalyst prepared by mixing the oxide catalyst powder represented by CrZrjAkOx (0.5≦j≦120, 0≦k≦50, A is a transition metal, x is the number satisfying the condition according to valences of Cr, Zr and A, and values of j and k) and carrier powder and sintering thereof, a composite catalyst wherein the oxide catalyst is impregnated on a carrier, and a method of preparing light olefin such as ethylene and propylene by hydrocarbon steam cracking in the presence of the composite catalyst. The composite catalyst of the present invention has excellent thermal/mechanical stability in the cracking process, and has less inactivation rate by coke and significantly increases light olefin yield. |
| US08569193B2 |
Preparation of surface functionalized porous organic-inorganic hybrid materials or mesoporous materials with coordinatively unsaturated metal sites and catalytic applications thereof
Disclosed herein is a method of surface-functionalizing a porous organic-inorganic hybrid material or a organic-inorganic mesoporous material, in which organic substances, inorganic substances, ionic liquids and organic-inorganic hybrid substances are selectively functionalized on the coordinatively unsaturated metal sites of a porous organic-inorganic hybrid material or organic-inorganic mesoporous material, and thus the porous organic-inorganic hybrid material can be used for adsorbents, gas storage devices, sensors, membranes, functional thin films, catalysts, catalytic supports, and the like, and the applications of the surface-functionalized porous organic-inorganic hybrid material prepared using the method to catalytic reactions. |
| US08569189B2 |
Electronic textile
The invention relates to an electronic textile comprising a textile substrate having a substrate electrode, and an electronic component having a component electrode. The component electrode is in electrically conductive contact with the substrate electrode via a coupling layer having a directionally dependent conductance so as to preferentially allow an electrical current to flow between the substrate electrode and the component electrode. As the coupling layer does not have to be patterned to prevent the occurrence of parasitic electrical currents, the electrically conductive contact between the substrate electrode and the component electrode has an improved reliability. |
| US08569186B2 |
Plasma CVD method, method for forming silicon nitride film and method for manufacturing semiconductor device
A plasma processing apparatus generates plasma by introducing microwaves into a processing chamber by using a planar antenna having a plurality of slots. By using the plasma processing apparatus, a nitrogen containing gas and a silicon containing gas introduced into the processing chamber are brought into the plasma state, and at the time of depositing by using the plasma a silicon nitride film on the surface of the a substrate to be processed, stress to the silicon nitride film to be formed is controlled by the combination of the type and the processing pressure of the nitrogen containing gas. |
| US08569185B2 |
Method of fabricating gate electrode using a treated hard mask
A method for fabricating an integrated device is disclosed. In an embodiment, a hard mask layer with a limited thickness is formed over a gate electrode layer. A treatment is provided to the hard mask layer to make the hard mask layer more resistant to a wet etch solution. Then, a patterning is provided on the treated hard mask layer and the gate electrode to from a gate structure. |
| US08569182B2 |
Methods of fabricating three-dimensional semiconductor device
A method of fabricating a three-dimensional semiconductor device includes forming a stacked structure, and the stacked structure includes a first layer, a second layer, a third layer, and a fourth layer sequentially stacked on a substrate. The method also includes forming a sacrificial spacer on a sidewall of the stacked structure such that the sacrificial spacer exposes a sidewall of the third layer, and recessing the exposed sidewall of the third layer thereby forming a recess region between the second and fourth layers. |
| US08569179B2 |
Method for etching organic hardmasks
A method of etching or removing an amorphous carbon organic hardmask overlying a low dielectric constant film in a lithographic process. The method includes providing a dielectric film having thereover an amorphous carbon organic hardmask to be removed, the dielectric film having a dielectric constant no greater than about 4.0, introducing over the amorphous carbon organic hardmask an ionizable gas comprising a mixture of hydrogen and an oxidizing gas, and applying energy to the mixture to create a plasma of the mixture. The method further includes contacting the amorphous carbon organic hardmask with the plasma, with the amorphous carbon organic hardmask being at a temperature in excess of 200° C., to remove the amorphous carbon organic hardmask without substantially harming the underlying substrate. |
| US08569174B2 |
Using spectra to determine polishing endpoints
Methods of determining a polishing endpoint are described using spectra obtained during a polishing sequence. In particular, techniques for using only desired spectra, faster searching methods and more robust rate determination methods are described. |
| US08569168B2 |
Dual-metal self-aligned wires and vias
Method of forming a semiconductor structure which includes forming first conductive spacers on a semiconductor substrate; forming second conductive spacers with respect to the first conductive spacers, at least one of the second conductive spacers adjacent to and in contact with each of the first conductive spacers to form combined conductive spacers; recessing the second conductive spacers with respect to the first conductive spacers so that the first conductive spacers extend beyond the second conductive spacers; depositing an ILD to cover the first and second spacers except for an exposed edge of the first conductive spacers; patterning the exposed edges of the first conductive spacers to recess the edges of the first conductive spacers in predetermined locations to form recesses with respect to the ILD; and filling the recesses with an insulating material to leave unrecessed edges of the first conductive spacers as vias to subsequent wiring features. |
| US08569166B2 |
Methods of modifying interlayer adhesion
Methods are provided for processing a substrate for depositing an adhesion layer having a low dielectric constant between two low k dielectric layers. In one aspect, the invention provides a method for processing a substrate including depositing a barrier layer on the substrate, wherein the barrier layer comprises silicon and carbon and has a dielectric constant less than 4, depositing a dielectric initiation layer adjacent the barrier layer, and depositing a first dielectric layer adjacent the dielectric initiation layer, wherein the dielectric layer comprises silicon, oxygen, and carbon and has a dielectric constant of about 3 or less. |
| US08569160B2 |
Device fabrication
Device fabrication is disclosed, including forming a first part of a device at a first fabrication facility as part of a front-end-of-the-line (FEOL) process, the first part of the device comprising a base wafer formed by FEOL processing, and subsequently performing one or more back-end-of-the-line (BEOL) processes at a second fabrication facility to form an IC, the one or more BEOL processes comprising finishing the forming of the device (e.g., an IC including memory) by depositing one or more memory layers on the base wafer. FEOL processing can be used to form active circuitry die (e.g., CMOS circuitry on a Si wafer) and BEOL processing can be used to form on top of each active circuitry die, one or more layers of cross-point memory arrays formed by thin film processing technologies that may or may not be compatible with or identical to some or all of the FEOL processes. |
| US08569159B2 |
CMOS structure including non-planar hybrid orientation substrate with planar gate electrodes and method for fabrication
A semiconductor structure and a method for fabricating the semiconductor structure include a hybrid orientation substrate having a first active region having a first crystallographic orientation that is vertically separated from a second active region having a second crystallographic orientation different than the first crystallographic orientation. A first field effect device having a first gate electrode is located and formed within and upon the first active region and a second field effect device having a second gate electrode is located and formed within and upon the second active region. Upper surfaces of the first gate electrode and the second gate electrode are coplanar. The structure and method allow for avoidance of epitaxial defects generally encountered when using hybrid orientation technology substrates that include coplanar active regions. |
| US08569157B2 |
Stepped masking for patterned implantation
An improved method of moving a mask to perform a pattern implant of a substrate is disclosed. The mask has a plurality of apertures, and is placed between the ion source and the substrate. After the substrate is exposed to the ion beam, the mask is indexed to a new position relative to the substrate and a subsequent implant step is performed. Through the selection of the aperture size and shape, the index distance and the number of implant steps, a variety of implant patterns may be created. In some embodiments, the implant pattern includes heavily doped horizontal stripes with lighter doped regions between the stripes. In some embodiments, the implant pattern includes a grid of heavily doped regions. In other embodiments, the implant pattern is suitable for use with a bus-bar structure. |
| US08569151B2 |
Method of formation of nanowires and method of manufacture of associated optical component
A method of formation of nanowires at a surface of a substrate attached to a solid immersion lens. The method includes formation of a catalyst element at the surface of the substrate and growth of nanowires from the catalyst element formed at the surface of the substrate. The catalyst element is a metal nanoparticle and the formation of the catalyst element at the surface of the substrate deposits the metal nanoparticle using a light beam focused by the solid immersion lens at the surface of the substrate. |
| US08569150B2 |
Method for producing a semiconductor device with a semiconductor body
A semiconductor device with a semiconductor body and method for its production is disclosed. The semiconductor body includes drift zones of epitaxially grown semiconductor material of a first conduction type. The semiconductor body further includes charge compensation zones of a second conduction type complementing the first conduction type, which are arranged laterally adjacent to the drift zones. The charge compensation zones are provided with a laterally limited charge compensation zone doping, which is introduced into the epitaxially grown semiconductor material. The epitaxially grown semiconductor material includes 20 to 80 atomic % of the doping material of the drift zones and a doping material balance of 80 to 20 atomic % introduced by ion implantation and diffusion. |
| US08569148B2 |
Final polishing method for silicon single crystal wafer and silicon single crystal wafer
The present invention provides a final polishing method for a silicon single crystal wafer that performs final polishing with a polishing rate being set to 10 nm/min or below at a final polishing step as a final step among a plurality of polishing steps for polishing the silicon single crystal wafer with a polishing slurry being interposed between the silicon single crystal wafer and a polishing pad, and a silicon single crystal wafer subjected to final polishing by this method. Hereby, there can be provided the final polishing method that can obtain a silicon single crystal wafer with less PIDs (Polishing Induced Defects) and the silicon single crystal wafer subjected to final polishing by this method. |
| US08569140B2 |
Method of fabricating semiconductor device
A method for fabricating a semiconductor device is disclosed. One embodiment of the method includes forming a dummy gate pattern on a substrate, forming an interlayer dielectric film that covers the dummy gate pattern, exposing a top surface of the dummy gate pattern, selectively removing the dummy gate pattern to form a first gate trench, forming a sacrificial layer pattern over a top surface of the substrate in the first gate trench, the sacrificial layer pattern leaving a top portion of the first gate trench exposed, increasing an upper width of the exposed top portion of the first gate trench to form a second gate trench, and removing the sacrificial layer pattern in the second gate trench, and forming a non-dummy gate pattern in the second gate trench. |
| US08569137B1 |
Method of improving PMOS performance in a contact etch stop layer process
A method of improving PMOS performance in a contact etch stop layer process is disclosed. The method includes: a first step for sequentially forming a first silicon dioxide layer, a hydrogen-containing silicon nitride layer and a second silicon dioxide layer on a semiconductor wafer; a second step for etching the second silicon dioxide layer; a third step for irradiating the resulting structure obtained after the step 2 with ultra-violet light; and a fourth step for removing the portions of the second silicon dioxide layer remained over the PMOS devices. By irradiating the low-stress silicon nitride layer deposited over the NMOS devices by UV light, a high tensile stress is generated in the silicon nitride over the NMOS devices while there is no high tensile stress in the silicon nitride over the PMOS devices, thus reducing disadvantageous effects of the CESL process on the performance of PMOS devices. |
| US08569136B2 |
Manufacturing method of semiconductor device
A manufacturing method of a semiconductor device is provided which can improve the performance of the semiconductor device. Ion implantation is applied to nMIS regions 1A and 1B and pMIS regions 1C and 1D of a semiconductor substrate 1 with offset spacers formed over sidewalls of gate electrodes GE1, GE2, GE3, and GE4 to thereby form extension regions for source and drain. In this case, a different photoresist pattern is used for each of the nMIS regions 1A and 1B and the pMIS regions 1C and 1D to individually perform the corresponding ion implantation. Every time the photoresist pattern is re-created, the offset spacer is also re-created. |
| US08569134B2 |
Method to fabricate a closed cell trench power MOSFET structure
A closed cell trench MOSFET structure having a drain region of a first conductivity type, a body of a second conductivity type, a trenched gate, and a plurality of source regions of the first conductivity type is provided. The body is located on the drain region. The trenched gate is located in the body and has at least two stripe portions and a cross portion. A bottom of the stripe portions is located in the drain region and a bottom of the cross portion is in the body. The source regions are located in the body and at least adjacent to the stripe region of the trenched gate. |
| US08569133B2 |
Nonvolatile semiconductor memory device and method of manufacturing the same
A nonvolatile semiconductor memory device includes a plurality of memory strings, each of which has a plurality of electrically rewritable memory cells connected in series; and select transistors, one of which is connected to each of ends of each of the memory strings. Each of the memory strings is provided with a first semiconductor layer having a pair of columnar portions extending in a perpendicular direction with respect to a substrate, and a joining portion formed so as to join lower ends of the pair of columnar portions; a charge storage layer formed so as to surround a side surface of the columnar portions; and a first conductive layer formed so as to surround the side surface of the columnar portions and the charge storage layer, and configured to function as a control electrode of the memory cells. Each of the select transistors is provided with a second semiconductor layer extending upwardly from an upper surface of the columnar portions; and a second conductive layer formed so as to surround a side surface of the second semiconductor layer with a gap interposed, and configured to function as a control electrode of the select transistors. |
| US08569131B2 |
Source/drain-to-source/drain recessed strap and methods of manufacture of same
A structure and a method of making the structure. The structure includes first and second semiconductor regions in a semiconductor substrate and separated by a region of trench isolation in the semiconductor substrate; a first gate electrode extending over the first semiconductor region; a second gate electrode extending over the second semiconductor region; a trench contained in the region of trench isolation and between and abutting the first and second semiconductor regions; and an electrically conductive strap in the trench, the strap electrically connecting the first and second semiconductor regions. |
| US08569129B2 |
Device-manufacturing scheme for increasing the density of metal patterns in inter-layer dielectrics
A method includes forming a transistor at a surface of a semiconductor substrate, wherein the step of forming the transistor comprises forming a gate electrode, and forming a source/drain region adjacent the gate electrode. First metal features are formed to include at least portions at a same level as the gate electrode. Second metal features are formed simultaneously, and are over and contacting the first metal features. A first one of the second metal features is removed and replaced with a third metal feature, wherein a second one of the second metal features is not removed. A fourth metal feature is formed directly over and contacting the gate electrode, wherein the third and the fourth metal features are formed using a same metal-filling process. |
| US08569126B2 |
Semiconductor device and manufacturing method thereof
A semiconductor device includes a silicon substrate in which active regions of a memory cell are defined, a gate electrode formed on a device isolation insulating film to extend in a first direction, a first insulating film formed on the silicon substrate and the gate electrode, a first plug formed to penetrate the first insulating film, to overlap with the gate electrode and the first active region, and to extend in a second direction perpendicular to the first direction, a second plug penetrating the first insulating film above the second active region, a second insulating film formed on the first insulating film, and an interconnection buried in the second insulating film, and formed to recede from a side surface of the first plug in the second direction and to cover only part of an upper surface of the first plug. |
| US08569120B2 |
Method for manufacturing thin film transistor
An object is to provide a method for manufacturing a thin film transistor having favorable electric characteristics, with high productivity. A gate electrode is formed over a substrate and a gate insulating layer is formed over the gate electrode. A first semiconductor layer is formed over the gate insulating layer by generating plasma using a deposition gas containing silicon or germanium, hydrogen, and a rare gas. Next, a second semiconductor layer including an amorphous semiconductor and a microcrystal semiconductor is formed in such a manner that the first semiconductor layer is partially grown as a seed crystal by generating plasma using a deposition gas containing silicon or germanium, hydrogen, and a gas containing nitrogen. Then, a semiconductor layer to which an impurity imparting one conductivity is added is formed and a conductive film is formed. Thus, a thin film transistor is manufactured. |
| US08569119B2 |
Method for producing semiconductor device and display device
A step of forming wiring using first solution ejection means for ejecting a conductive material, a step of forming a resist mask on the wiring using second solution ejection means, and a step of etching the wiring using an atmospheric-pressure plasma device having linear plasma generation means or an atmospheric-pressure plasma device having a plurality of linearly-arranged plasma-generation-means using the resist mask as a mask are included. |
| US08569116B2 |
Integrated circuit with a fin-based fuse, and related fabrication method
Methods of fabricating an integrated circuit with a fin-based fuse, and the resulting integrated circuit with a fin-based fuse are provided. In the method, a fin is created from a layer of semiconductor material and has a first end and a second end. The method provides for forming a conductive path on the fin from its first end to its second end. The conductive path is electrically connected to a programming device that is capable of selectively directing a programming current through the conductive path to cause a structural change in the conductive path to increase resistance across the conductive path. |
| US08569115B1 |
Method of forming a compliant bipolar micro device transfer head with silicon electrodes
A compliant bipolar micro device transfer head array and method of forming a compliant bipolar micro device transfer array from an SOI substrate are described. In an embodiment, a compliant bipolar micro device transfer head array includes a base substrate and a patterned silicon layer over the base substrate. The patterned silicon layer may include first and second silicon interconnects, and first and second arrays of silicon electrodes electrically connected with the first and second silicon interconnects and deflectable into one or more cavities between the base substrate and the silicon electrodes. |
| US08569113B2 |
Method for producing a microfluid component, as well as microfluid component
A method for producing a microfluid component includes: Producing a single polymer layer made of at least one plastic or a plastic composite and having a microfluid structure, fitting the polymer layer with at least one semiconductor element, and/or with at least one electronic component, and/or with an optical or optoelectronic component, sealing the microfluid structure. |
| US08569111B2 |
Manufacturing method for semiconductor devices
The reliability of a semiconductor device is enhanced. A first lead frame, a first semiconductor chip, a second lead frame, and a second semiconductor chip are stacked over an assembly jig in this order with solder in between and solder reflow processing is carried out to fabricate their assembly. Thereafter, this assembly is sandwiched between first and second molding dies to form an encapsulation resin portion. The upper surface of the second die is provided with steps. At a molding step, the second lead frame is clamped between the first and second dies at a position higher than the first lead frame; and a third lead frame is clamped between the first and second dies at a higher position. The assembly jig is provided with steps at the same positions as those of the steps in the upper surface of the second die in positions corresponding to those of the same. |
| US08569085B2 |
Photoelectrochemical etching for chip shaping of light emitting diodes
A photoelectrochemical (PEC) etch is performed for chip shaping of a device comprised of a III-V semiconductor material, in order to extract light emitted into guided modes trapped in the III-V semiconductor material. The chip shaping involves varying an angle of incident light during the PEC etch to control an angle of the resulting sidewalls of the III-V semiconductor material. The sidewalls may be sloped as well as vertical, in order to scatter the guided modes out of the III-V semiconductor material rather than reflecting the guided modes back into the III-V semiconductor material. In addition to shaping the chip in order to extract light emitted into guided modes, the chip may be shaped to act as a lens, to focus its output light, or to direct its output light in a particular way. |
| US08569075B2 |
Radioimmunoassay with a 96-welled micro-plate
A method for using a multi-welled micro-plate in radioimmunoassay (“RIA”) is disclosed to improve the performance of RIA. At first, there is provided a multi-welled micro-plate that can be dismantled and divided into multiple wells. Then, samples are filled into the wells of the multi-welled micro-plate for incubation. Washing, tracer-adding, incubation, and washing are executed. At a final step, the multi-welled micro-plate is separated into wells, and each of to the wells is put into a test tube for gamma counting by a gamma counter. |
| US08569073B2 |
Test element having combined control and calibration zone
A test element, for example in the form of an immunological test strip functioning according to the sandwich principle, for the fluorophoric detection of one or more analytes in a sample comprising an analyte detection zone and a combined control and calibration zone. The combined control and calibration zone include a fluorophore and binding partners for the specific binding of reagents labelled with a fluorophore. Furthermore, the invention concerns a method for calibrating an analyte-specific measurement signal, a method for determining the concentration of an analyte in a sample and the use of the test element for calibrating a signal generated in the analyte detection zone of a test element. |
| US08569070B2 |
Connection assembly for ultra high pressure liquid chromatography
A fitting assembly having a nut, a ferrule, and a ferrule tip that may be assembled by an operator. The fitting assembly includes a nut with first and second ends, with the second end adapted to receive the first end of a ferrule, and a ferrule tip with a first end having an externally tapered portion adapted to abut the second end of the ferrule and a second end adapted to be received in a component or fitting of a liquid chromatography system. The nut, ferrule and ferrule tip of the fitting assembly have passageways therethrough for receiving and removably holding tubing. |
| US08569066B2 |
Genetically engineered recombinant Escherichia coli producing L-tryptophan having originally L-phenylalanine productivity, and method for producing L-tryptophan using the microorganism
The present invention relates to a microorganism having L-tryptophan productivity and a method for producing L-tryptophan using the same. More precisely, the present invention relates to the recombinant E. coli strain CJ600 (KCCM 10812P) having tryptophan productivity produced from the mutant form (KFCC 10066) of E. coli having L-phenylalanine productivity, wherein tryptophan auxotrophy is released, L-phenylalanine biosynthesis is blocked but tryptophan productivity is enhanced by reinforcing the gene involved in tryptophan biosynthesis, and a method of producing L-tryptophan using the same. |
| US08569063B1 |
Planta gold nanoparticle manufacture
Disclosed is a method for manufacturing a plurality of gold nanoparticles in a plant, the method comprising growing the plant hydroponically, contacting at least a first part of the plant with a substance comprising at least one gold salt, providing an average photosynthetic active radiation (PAR) to at least second part of the plant, waiting a period of time sufficient for formation of a plurality of gold nanoparticles in at least a portion of the plant, thereby manufacturing the plurality of gold nanoparticles in the plant. Disclosed also are, inter alia, a plurality of gold nanoparticles manufactured by such a method; an article of manufacture comprising a plurality of gold nanoparticles manufactured by such a method; and a plurality of triangular gold nanoparticles manufactured by such a method. |
| US08569062B2 |
Cryogels of PVA-boronic acid containing co-polymers for cell culture
The present invention relates to a cryogel which contains a polyol selected from polyvinyl alcohol or galactomannan and a co-polymer of Formula I: The cryogel is formed by mixing the monomers of the co-polymer of Formula I at a temperature of less about 5 degrees C. with the polyol and a free radical initiator in an aqueous solution and polymerizing the solution to form the cryogel. The cryogel is used for culturing cells and can be decomposed by contact with a monosaccharide. |
| US08569060B2 |
Method of producing a population of cells
An in vitro or ex vivo method of producing a population of lineage committed haematopoietic progenitor or mature haematopoietic cells other than cells of the neutrophil lineage, including the steps of providing a population of haematopoietic progenitor cells; and culturing the haematopoietic progenitor cells in an animal cell culture medium including one or more cytokines that differentiate the haematopoietic progenitor cells into lineage committed haematopoietic progenitor and/or mature haematopoietic cells, under static conditions until the cells are at a cell density at which oxygen transfer via the surface of the culture medium is insufficient for growth of the progenitor cells and progeny thereof under static conditions, and then agitating the culture medium to produce a population of lineage committed haematopoietic progenitor or mature haematopoietic cells other than cells of the neutrophil lineage. |
| US08569059B2 |
Method of identifying CD4+ CD25+ T-cells activated to an antigen which express CD8
The invention relates to a method of identifying CD4+ CD25+ T cells activated to an antigen in a population of T cells, comprising identifying CD4+ CD25+ T cells which express CD8. The invention also relates to a method of isolating CD4+ CD25+ T cells activated to an antigen comprising isolating CD4+ CD25+ T cells which express CD8. The invention also relates to a method of increasing tolerance to an antigen in a subject comprising administering CD4+ CD25+ T cells which express CD8. |
| US08569058B2 |
Nerve regeneration promoters
A nerve regeneration which comprises a compound is represented by formula (I): (wherein all symbols are shown in the description), a salt thereof or a prodrug thereof. The compound of the present invention is suppresses nerve cell death as a substance for accelerating growth and/or differentiation of stem cells (nerve stem cells, embryonic stem cells, bone marrow cells, etc.), a substance for accelerating growth and/or differentiation of nerve precursor cells, a potentiator for neurotrophic factor activity, a neurotrophic factor-like substance or a neurodegenerative suppressor, and accelerates repair and regeneration of nerve tissues by neogenesis, regeneration and/or axon evolution. In addition, the compound of the present invention is useful for preparation from brain tissues, bone marrow and/or embryonic stem cells of cells for transplant (nerve stem cells, nerve precursor cells, nerve cells, etc.) and also accelerates grafting, growth, differentiation and/or function expression of cells for transplant whereupon it is useful for prevention and/or treatment of neurodegenerative diseases. |
| US08569055B2 |
Identification and characterization of cancer stem cells and methods of use
A subpopulation of cancer stem cells expressing elevated levels of uPAR have been identified among a population of cancer cells. Methods are provided for treating proliferative disorders such as cancer by administering one or more uPAR inhibitors. Methods are likewise provided for predicting the likelihood of recurrence of a cancer, preventing recurrence of a cancer, and identifying the likelihood of a cancer to respond to a particular cancer therapy. |
| US08569054B2 |
Mammalian cell lines for increasing longevity and protein yield from a cell culture
Disclosed are compositions and methods for increasing the longevity of a cell culture and permitting the increased production of proteins, preferably recombinant proteins, such as antibodies, peptides, enzymes, growth factors, interleukins, interferons, hormones, and vaccines. Cells transfected with an apoptosis-inhibiting gene or vector, such as a triple mutant Bcl-2 gene, can survive longer in culture, resulting in extension of the state and yield of protein biosynthesis. Such transfected cells exhibit maximal cell densities that equal or exceed the maximal density achieved by the parent cell lines. Transfected cells can also be pre-adapted for growth in serum-free medium, greatly decreasing the time required to obtain protein production in serum-free medium. In certain methods, the pre-adapted cells can be used for protein production following transformation under serum-free conditions. The method preferably involves eukaryotic cells, more preferably mammalian cells. |
| US08569048B2 |
Actuators for culturing and harvesting cells
Actuator units, arrangements of actuator units and methods for manufacturing and using actuator units are provided. The actuator includes a core having a shell at least partially surrounding the core. The core is able to be stimulated to expand through at least one opening of the shell to provide a lifting action. This lifting action can be applied to harvest target cells. |
| US08569047B2 |
Microbial detection apparatus, microbial detection method, and sample container used therein
The sample container has a two-layer membrane filter comprising a first layer as an upper layer serving as a hydrophilic membrane filter and a hydrophobic membrane filter as an underlying second layer capable of filtering an aqueous solution without the use of a wetting agent and by means of a formed negative pressure. Using this sample container, a large amount of an aqueous sample solution is filtered by means of a negative pressure formed by a suction portion to capture microbes in the aqueous sample solution by the hydrophilic membrane filter. Then, the negative pressure is restored to normal pressure, and a microbial dissolution solution is then added to the membrane filter to retain the microbial dissolution solution for a given time on the hydrophobic membrane filter. Then, the microbial dissolution solution is dispensed to a reaction container containing a luminescent reagent, and luminescence is detected to detect the microbes. |
| US08569045B2 |
Water toxicity detecting apparatus and method using sulfur particles
Provided are a water toxicity detecting apparatus and a method using sulfur particles. The water toxicity detecting apparatus using sulfur particles includes: a reaction container containing microbes, in which externally-supplied sulfur particles and oxygen are reacted to form sulfate ions by the microbes; a water sample inlet through which a water sample is flown into the reaction container; an air inlet through which an air is flown into the reaction container; a first detection unit which detects pH and electrical conductivity of the inflow water sample flown through the water sample inlet; a second detection unit which detects pH and electrical conductivity of the water sample containing the sulfate ions generated in the reaction container; a central processing unit which stores data of the ph and electrical conductivity of the inflow water sample flown through the water sample inlet, adjusts a pumping speed of a pump provided to the water sample inlet and a flow rate of the air, and compares data of the first detection unit with data of the second detection unit to determine presence of toxicity of the water sample; and an outlet through the after-toxicity-test water sample is exhausted from the reaction container. |
| US08569043B2 |
Detection of post-translationally modified peptides with liquid crystals
A method for differentiating between a post-translationally modified peptide and a peptide contained in a sample, comprising: (a) contacting the sample with a peptide attachment surface to create a peptidized surface, wherein the sample includes at least one functional group; (b) contacting the peptidized surface with a recognition reagent that selectively binds or forms a complex with the post-translationally modified peptide in the sample to provide an incubated surface; and (c) contacting a liquid crystal with the incubated surface and detecting presence of post-translationally modified peptide in the sample with the liquid crystal. |
| US08569042B2 |
DNA structures on ferroelectrics and semiconductors
An apparatus includes a substrate and a plurality of DNA oligomers in contact with a top surface of the substrate. The substrate is a polar ferroelectric or a polar compound semiconductor. |
| US08569041B2 |
Multiplex automated genome engineering
The present invention relates to automated methods of introducing multiple nucleic acid sequences into one or more target cells. |
| US08569036B2 |
Immobilized TAL biocatalyst for production of para-hydroxycinnamic acid
TAL cell biocatalyst was immobilized in alginate cross-linked beads using low concentrations of glutaraldehyde. The biocatalyst beads have highly stable TAL activity and mechanical strength such that they withstand prolonged recycling in production of pHCA. |
| US08569035B2 |
Subtilase variants
The present invention relates to novel subtilase variants exhibiting alterations relative to the parent subtilase in one or more properties including: Wash performance, thermal stability, storage stability or catalytic activity. The variants of the invention are suitable for use in e.g. cleaning or detergent compositions, such as laundry detergent compositions and dishwash compositions, including automatic dishwash compositions. |
| US08569034B2 |
Thermolysin variants and detergent compositions therewith
The present invention provides methods and compositions comprising at least one thermolysin-like neutral protease enzyme with improved storage stability and/or catalytic activity. In some embodiments, the thermolysin finds use in cleaning and other applications comprising detergent. In some particularly preferred embodiments, the present invention provides methods and compositions comprising thermolysin formulated and/or engineered to resist detergent-induced inactivation. |
| US08569022B2 |
Extracellular aldonolactonase
The present disclosure relates to hydrolysis of hexose-δ-lactones by use of an S. thermophile extracellular aldonolactonase. In particular the present disclosure relates to compositions including a S. thermophile extracellular aldonolactonase and methods of use thereof. |
| US08569014B2 |
Microorganism and method for producing canthaxanthin
A carotenoid producing bacterium belonging to the genus Paracoccus that selectively produces canthaxanthin so that the amount thereof is not less than 90 percent by weight of the total amount of produced carotenoids including β-carotene, β-cryptoxanthin, echinenone, canthaxanthin, 3-hydroxyechinenone, 3′-hydroxyechinenone, zeaxanthin, phoenicoxanthin, adonixanthin, and astaxanthin. A method for producing canthaxanthin by culturing the above bacterium, and then collecting carotenoids from bacterial cells or a culture solution after the culturing. |
| US08569011B2 |
Fluorescent derivatives of polyamines, method for preparing same and applications thereof as diagnosis tools in the treatment of cancerous tumors
The invention relates to novel fluorescent derivatives of polyamines having a benzoxadiazole group, to a method for preparing the same and to the use thereof as diagnosis tools for emphasising the polyamine transport system in cancerous cells in order to adapt the treatment thereof, and thus for selecting patients carrying such tumors in order to adapt their treatment. The derivatives are of the formula (I) or a pharmaceutically acceptable salt thereof, in which: R1 is one or more NO2 groups in position 4 or 6, or a SO2Ph, SO2NMe2, SO2NH2 or SO3H group; R2 is hydrogen, C1-6 alkyl, benzyl, a perfluoroalkyl group; the values of a, b, c range from 2 to 5 independently from each other and represent alkylene chains separating the amino groups, and the values of d and e can independently be 0 or 1. |
| US08568993B2 |
Detection of glycopeptides and glycoproteins for medical diagnostics
A diagnostic method for determining the absence or presence of a disease is provided. The method includes assaying the amount and/or types of glycopeptides in a sample from a subject, and comparing these to the amount and types of reference glycopeptides. The method may include the use of a stable isotope label, affinity selection, immunoaffinity chromatography, and glycoproteomics techniques, to identify and quantify changes in glycosylated peptides or glycosylated proteins associated with cancers such as malignant lymphoma or breast cancer, to monitor patient's response to therapy, and to monitor disease recurrence. |
| US08568986B2 |
Method of selecting an agent that improves periodontal disease
A marker for determining the onset of periodontal disease and a marker far determining the progression stage of periodontal disease, each containing autoinducer-2. |
| US08568985B2 |
Breast endothelial cell expression patterns
To gain a better understanding of breast tumor angiogenesis, breast endothelial cells (ECs) were isolated and evaluated for gene expression patterns. When transcripts from breast ECs derived from normal and malignant breast tissues were compared, genes that were specifically elevated in tumor-associated breast endothelium were revealed. These results confirm that neoplastic and normal endothelium in human breast are distinct at the molecular level, and have significant implications for the development of anti-angiogenic therapies in the future. |
| US08568982B2 |
Methods of nucleic acid synthesis using particular crowding agents and concentrations
The invention provides a method of nucleic acid synthesis and/or amplification, and/or of improving the efficiency, activity and/or stability of at least one nucleic acid-modifying enzyme, comprising carrying out the method in the presence of (a) at least one organic-based macromolecule having a molecular weight of 50 kDa to 500 kDa and neutral surface charge; or (b) at least one organic-based macromolecule of radius 2 to 50 nm and neutral surface charge. There is also provided a method of determining the optimum crowding conditions of macromolecule(s) in solution. |
| US08568981B2 |
Probe and method for detection and discrimination of types and subtypes of influenza viruses
Methods of detecting influenza, including differentiating between type and subtype are disclosed, for example to detect, type, and/or subtype an influenza infection. A sample suspected of containing a nucleic acid of an influenza virus, is screened for the presence or absence of that nucleic acid. The presence of the influenza virus nucleic acid indicates the presence of influenza virus. Determining whether the influenza virus nucleic acid is present in the sample can be accomplished by detecting hybridization between an influenza specific probe, influenza type specific probe, and/or subtype specific probe and an influenza nucleic acid. Probes and primers for the detection, typing and/or subtyping of influenza virus are also disclosed. Kits and arrays that contain the disclosed probes and/or primers also are disclosed. |
| US08568978B1 |
Use of mammalian expression vector including T7 promoter and N-terminal HA tag for overexpression of human genes in E. coli
The present invention relates to a technique for the T7 promoter-driven expression of a foreign protein, preferably, a human protein in E. coli having no T7 RNA polymerase. More particularly, the present invention relates to use of a vector including a T7 promoter and an N-terminal HA tag sequence for overexpression of a foreign protein in E. coli having no T7 RNA polymerase, E. coli that includes the vector and is able to overexpress the foreign protein in the absence of T7 RNA polymerase, a method for expressing or producing the foreign protein using the E. coli, and a method for analyzing functions of the foreign protein. Further, the present invention relates to a simple, rapid method for evaluating the expression and cytotoxicity of a human protein in E. coli by using the vector. |
| US08568977B2 |
Compositions and methods for diagnosis and treatment of tumors
Based on the observation of the cooperation of osteopontin (OPN) and matrixmetalloproteinase-9 (MMP-9) in the promotion of the metastatic phenotype, therapies and diagnostic assays are disclosed for the treatment of a tumor that overexpresses OPN, such as hepatocellular carcinoma (HCC), for example metastatic HCC. In one example, methods of treating a tumor include administration of an agent that reduces cellular invasion resulting from the interaction between a fragment of OPN (OPN-5kD) generated by MMP-9 cleavage and CD44 receptor. Examples of such agents include fragments of OPN-5kD and antibodies specific for OPN-5kD. Therapeutic compositions are also provided that include such agents. Also provided are methods of diagnosing or prognosing a tumor, for example by detecting expression of OPN-5kD peptide or OPN-c mRNA in a biological sample obtained from the subject. Also provided are antibodies that specifically bind OPN-5kD. |
| US08568972B2 |
Substances causing differentiation
A DNA construct is described which contains a fusion gene under the control of a promoter. The fusion gene comprises at least one resistance gene and at least one reporter gene and is slightly toxic to a host cell transfected with that DNA construct. That DNA construct can be encoded on a plasmid or a virus. Further, a method is described for using the DNA construct to identify substances that may cause a differentiation in eukaryotic cells. |
| US08568970B2 |
Bacteriophages as selective agents for enriching target bacteria
Compositions containing bacteriophages and methods of using bacteriophages in microorganism detection assays and microbial growth and plating media are disclosed. The lytic ability of these phages to control the growth of non-target populations provides superior sensitivity and specificity to detection assays and reduces false negative and false positive results. The removal of contaminating bacteria reduces the microbial competition for nutrients in the growth media thereby increasing the efficiency and productivity of the culture. The phage treatment of the sample increases the proportion of target microorganisms in the sample over contaminating bacteria thereby requiring less time for enrichment to obtain a significant signal improving overall signal to noise ratio in assays and providing for higher yield of end product in microbiological production systems. |
| US08568969B2 |
RBP4 in insulin sensitivity/resistance, diabetes, and obesity
Methods for screening molecules that modulate the activity of Retinol Binding Protein 4 (RBP4) and their use in treatment of insulin resistance are described. Also described are methods of diagnosing insulin resistance and related conditions by detecting modulation of RBP4 activity. |
| US08568966B2 |
Method and apparatus for producing a molecular film with an adjusted density
An object of the present invention is to provide a technique that can adjust a molecular density of the film of functional molecules (e.g. DNA molecules), which is utilized for biochips such as DNA chip, to a desired degree efficiently and easily. The method for producing a molecular film with an adjusted density according to the present invention includes forming a molecular film and adjusting a molecular density. In the forming a molecular film, a molecular film composed of molecules is formed on a conductive substrate, wherein the molecule includes a region capable of binding to the conductive substrate at least in a portion thereof. In the density adjusting, a molecular density of the molecular film is adjusted by desorbing a part of the molecules which make up the molecular film from the conductive substrate. |
| US08568959B2 |
Techniques for reducing degradation and/or modifying feature size of photomasks
A photomask includes a light transmitting substrate and an absorber layer adjacent thereto. The absorber layer includes a silicide, such as molybdenum silicide, patterned into a plurality of features. The surrounding environment is controlled to prevent undesirable growth by oxidation of the absorber layer when the mask is exposed to light while being used to fabricate integrated circuits. In another aspect, the surrounding environment is controlled to encourage desirable growth by oxidation of the absorber layer when the mask is exposed to light. |
| US08568957B2 |
Data storage media containing inorganic nanomaterial data layer
Optical information media having a support substrate and an inorganic nanomaterial data layer are disclosed. The data layer provides enhanced stability and optical performance as compared to conventional data layers. |
| US08568955B2 |
Composition for formation of top antireflective film, and pattern formation method using the composition
Disclosed is a composition for forming a top antireflective film, which comprises at least one fluorine-containing compound and a quaternary ammonium compound represented by the formula (1) [wherein at least one of R1, R2, R3, and R4 represents a hydroxyl group or an alkanol group, and the others independently represent a hydrogen or an alkyl group having 1 to 10 carbon atoms; and X− represents a hydroxyl group, a halide ion or a sulfate ion], and optionally a water-soluble polymer, an acid, a surfactant and an aqueous solvent. The composition for forming a top antireflective film can exhibit the same levels of functions as those of conventional top antireflective film-forming compositions when applied in a smaller amount. |
| US08568954B2 |
Positive photosensitive resin composition
A positive photosensitive resin composition according to one embodiment of the present invention includes a polyamic acid or a polyamic acid ester compound including a repeating unit represented by Formula 1 defined in this specification, a photosensitive diazoquinone compound, a silane compound, a phenol compound, and a solvent. The positive photosensitive resin composition can be cured at a low temperature of 260° C. or less, and can have high sensitivity, resolution, residue removal, substrate adherence, and pattern-forming capabilities, and low film shrinkage. |
| US08568947B2 |
Green toner for developing static latent image and full color image forming method
Disclosed is a green toner for developing a static latent image containing a binder resin and a colorant, and the colorant contains C.I. Solvent Green 5 and colorant compound X represented by Formula (1), and content ratio of C.I. Solvent Green 5 in whole amount of the colorant is 5 to 50% by weight, in the Formula (1), M1 is a metal atom of Group 14, Q is independently a monovalent substituent, m and n are each 0 or 1, at least one of m and n is 1, and A is independently an atomic group forming an aromatic ring which may have a substituent. |
| US08568940B2 |
Joining bipolar plates using localized electrical nodes
A bipolar plate assembly for a fuel cell is provided. The bipolar plate assembly includes a first unipolar plate disposed adjacent to a second unipolar plate. The first unipolar plate and the second unipolar plate are bonded by a plurality of localized electrically conductive nodes. A fuel cell stack including the bipolar plate assembly and a method for preparing the bipolar plate assembly are also described. |
| US08568935B2 |
Method for managing fuel cell power increases using air flow feedback delay
A method for managing fuel cell power increases in a fuel cell system using an air flow feedback delay. The method comprises the steps of determining a required air mass flow rate at a predetermined point in the fuel cell system, determining an actual air mass flow at a predetermined point in the fuel cell system, calculating an air flow feedback delay as a function of the required air mass flow rate and the actual air mass flow, and delaying an external circuit from increasing current draw from the fuel cell stack by the magnitude of the air flow feedback delay. |
| US08568932B2 |
Nonaqueous electrolyte solution and lithium secondary battery using same
The present invention provides a nonaqueous electrolytic solution in which an electrolyte salt is dissolved in a nonaqueous solvent, containing 0.01% to 30% by weight of a 1,2-cyclohexanediol derivative having a specific structure; and a lithium secondary battery using the nonaqueous electrolytic solution. The lithium secondary battery exhibits excellent battery characteristics such as electrical capacity, cycle property, and storage property and can maintain excellent long-term battery performance. |
| US08568927B2 |
Nonaqueous electrolyte battery, battery pack and vehicle
A nonaqueous electrolyte battery includes a positive electrode, a negative electrode and a nonaqueous electrolyte. The negative electrode contains a lithium compound and a negative electrode current collector supporting the lithium compound. A log differential intrusion curve obtained when a pore size diameter of the negative electrode is measured by mercury porosimetry has a peak in a pore size diameter range of 0.03 to 0.2 μm and attenuates with a decrease in pore size diameter from an apex of the peak. A specific surface area (excluding a weight of the negative electrode current collector) of pores of the negative electrode found by mercury porosimetry is 6 to 100 m2/g. A ratio of a volume of pores having a pore size diameter of 0.05 μm or less to a total pore volume is 20% or more. |
| US08568923B1 |
Electrode for lithium secondary battery
Disclosed is a method for forming an electrode comprising a protective layer, which comprises: dispersing or dissolving an aliphatic nitrile compound into a solvent to provide a coating solution; coating a surface of the electrode with the coating solution, said electrode having an electrode active material coated thereon; and removing the solvent used in the coating solution by drying to form a protective layer comprising an aliphatic nitrile compound-electrode active material complex. |
| US08568921B1 |
Regenerative ion exchange fuel cell
A regenerative ion exchange fuel cell having an anode, a metal ion conductor coupled to the anode, an aqueous electrolyte solution positioned adjacent the metal ion conductor, a proton conductor mounted adjacent the aqueous electrolyte solution opposite the metal ion conductor, a cathode positioned adjacent the proton conductor opposite the aqueous electrolyte solution, and a cathode current collector associated with the cathode. |
| US08568920B2 |
Electrolytic solution and lithium battery employing the same
An organic electrolytic solution including a lithium salt, an organic solvent, and a linear or cyclic polymerizable monomer that is negatively charged due to localization of electrons on the monomer, and a lithium battery employing the same. Since the organic electrolytic solution prevents decomposition of an electrolyte and elution from or precipitation of metal ions, the lithium battery employing the organic electrolytic solution has excellent lifetime characteristics and cycle characteristics. |
| US08568917B2 |
Material for contact components or battery components, and battery using the same
A material for contact components or battery components, which includes a metal sheet having a surface layer portion containing a first metal element, the metal sheet including a Cr-containing steel plate or a surface-treated steel plate, and at least a part of the first metal element on an outermost surface of the surface layer portion being substituted by a second metal element having a nobler standard electrode potential than the first metal element, the second metal element being deposited on the outermost surface in a state of a particulate metal, oxide, or hydroxide. |
| US08568915B2 |
Battery with integrally formed terminal
A battery comprising a housing having a central longitudinal axis. A cover is coupled to the housing and a first flange is integrally formed with the cover and configured to act as a first terminal for the battery. At least a portion of the first flange extends away from the housing in a direction generally perpendicular to the central longitudinal axis. Wherein the first flange is configured for electrical coupling with a terminal of an adjacent battery in a battery system. for electrical coupling with a terminal of an adjacent battery in a battery system. |
| US08568912B2 |
Redox flow battery
A redox flow battery, in particular a vanadium redox flow battery, with at least two functional units, for example at least two stages with at least one battery cascade, or at least two battery cascades, has a device for electrically decoupling at least one of these units. In order to ensure fault-free and functionally reliable operation of an energy supply system on the basis of such a redox flow battery alongside best-possible efficiency, a device for connecting a decoupled functional unit to at least one store for electrical energy is provided. |
| US08568910B2 |
Protective circuit module for secondary battery and battery pack using the same
A protective circuit module for a secondary battery includes a circuit board. At least one protection control circuit element for preventing overcharge and over-discharge of the secondary battery is mounted on the circuit board. A first conductive pad is coupled to the circuit board. A positive temperature coefficient device is between the at least one protection control circuit and the first conductive pad such that when a secondary battery temperature reaches a threshold value, resistance of the positive temperature coefficient device is increased and battery current is reduced. |
| US08568907B2 |
Housing and method for making the same
A housing is provided which includes an aluminum or aluminum alloy substrate, an aluminum layer and a corrosion resistant layer formed on the aluminum or aluminum alloy substrate in that order. The corrosion resistant layer is an Al—C—N layer. Then, Nd ions are implanted in the Al—C—N layer by ion implantation process. The atomic percentages of N and C in the Al—C—N gradient layer gradually increase from the side of Al—C—N gradient layer near the aluminum or aluminum alloy substrate to the other side of Al—C—N gradient layer, away from aluminum or aluminum alloy substrate. Therefore the housing has a high corrosion resistance. A method for making the housing is also provided. |
| US08568905B2 |
Housing and method for making the same
A housing is provided which includes an aluminum or aluminum alloy substrate, an aluminum layer and a corrosion resistant layer formed on the aluminum or aluminum alloy substrate in that order. The corrosion resistant layer is an Al—C—N layer. Then, Gd ions is implanted in the Al—C—N layer by ion implantation process. The atomic percentages of N and C in the Al—C—N gradient layer gradually increase from the side of Al—C—N gradient layer near the aluminum or aluminum alloy substrate to the other side of Al—C—N gradient layer, away from aluminum or aluminum alloy substrate. Therefore the housing has a high corrosion resistance. A method for making the housing is also provided. |
| US08568904B2 |
Housing and method for making the same
A housing is provided which includes an aluminum or aluminum alloys substrate, an aluminum layer and a corrosion resistant layer formed on the aluminum or aluminum alloys substrate in that order. The corrosion resistant layer is an Al—O—N layer. Then, La ions is implanted in the Al—O—N layer by ion implantation process. The atomic percentages of N and O in the Al—O—N gradient layer gradually increase from the bottom of the layer near the aluminum or aluminum alloys substrate to the top of the layer away from aluminum or aluminum alloys substrate by physical vapor deposition. The housing has a higher corrosion resistance. A method for making the housing is also provided. |
| US08568901B2 |
Filler metal composition and method for overlaying low NOx power boiler tubes
An alloy for use as a welding overlay for boiler tubes in a low NOx coal-fired boiler comprising in % by weight: 36 to 43% Cr, 0.2 to 5.0% Fe, 0-2.0% Nb, 0-1% Mo, 0.3 to 1% Ti, 0.5 to 2% Al, 0.005 to 0.05% C, 0.005 to 0.020% (Mg+Ca), 0-1% Mn, 0-0.5% Si, less than 0.01% S, balance substantially Ni and trace additions and impurities. The alloy provides exceptional coal ash corrosion resistance in low partial pressures of oxygen. The alloy also increases in hardness and in thermal conductivity at service temperature over time. The increased hardness improves erosion resistance of the tubes while the increased thermal conductivity improves the thermal efficiency of the boiler and its power generation capabilities. |
| US08568899B2 |
Metal covered polyimide composite, process for producing the composite, and process for producing electronic circuit board
Provided is a metal covered polyimide composite comprising a tie-coat layer and a metal seed layer formed on a surface of a polyimide film by electroless plating or a drying method, and a copper layer or a copper alloy layer formed thereon by electroplating, wherein the copper plated layer or copper alloy plated layer comprises three layers to one layer of the copper layer or copper alloy layer, and there is a concentrated portion of impurities at the boundary of the copper layer or copper alloy layer when the copper layer or copper alloy layer is three layers to two layers, and there is no concentrated portion of impurities when the copper layer or copper alloy layer is a single layer. Additionally provided are a method of producing the composite and a method of producing an electronic circuit board. |
| US08568896B2 |
Low ignition propensity wrapping paper and method and machine of manufacturing same
A low ignition propensity wrapping paper includes a paper web and bands arranged on the web at predetermined intervals in a longitudinal direction of the web. These bands are formed by applying a combustion-inhibition liquid onto the web. The combustion-inhibiting liquid contains a solvent and a combustion inhibitor that is sodium alginate or pectin dissolved in the solvent. The solvent is treated water obtained by substantially removing at least calcium ions and magnesium ions from raw water of a water supply or a well. |
| US08568892B2 |
Coated articles
A coated article includes a substrate having on its surface a coating that includes a polymer selected from the group consisting of hydroxypropylcellulose, poly(2-ethyl-2-oxazoline) and mixtures of these, a surfactant, colloidal silica, and a crosslinker selected from the group consisting of water-soluble titanium salts and water-soluble or water-dispersible organic crosslinkers. The coating may be formed by applying a dispersion of the coating composition in a diluent to the substrate and subsequently drying the coated substrate to evaporate the diluent. |
| US08568891B2 |
Thermosetting resin composition of semi-IPN composite, and varnish, prepreg and metal clad laminated board using the same
Provided is a thermosetting resin composition which can be used for the production of printed circuit boards, having good dielectric properties in high frequency bands so that transmission loss can be significantly lowered, having excellent heat resistance after moisture absorption and thermal expansion properties, and satisfying peeling strength between the resin composition and metal foil.The present invention relates to a thermosetting resin composition of a semi-IPN composite, comprising (A) a polyphenylene ether, and a prepolymer formed from (B) a chemically unmodified butadiene polymer containing 40% or more of a 1,2-butadiene unit having a 1,2-vinyl group in a side chain of a molecule and (C) a crosslinking agent, in a compatibilized and uncured state; and a resin varnish, a prepreg and a metal clad laminated board using the same. |
| US08568890B2 |
Watch cover glass
A watch cover glass having high hardness and excellent abrasion, and also having flaw resistance and antireflection function even after being used for a long period of time. The watch cover glass comprises a transparent substrate and, provided on at least one surface of the substrate, an antireflection film having a lamination structure that a SiON film (SiO2 and Si3N4 mixed film) and a Si3N4 film are laminated and the outermost layer is the SiON film. Accordingly, the proper antireflection effect can be obtained, the hardness of the antireflection film is increased and the abrasion resistance is remarkably increased. As a result, even after being used for a long period of time, the surface of the antireflection film is not finely flawed and is not peeled off, and it hardly occurs that the hands or dial plate are invisible due to surface mist and the antireflection function can be maintained. |
| US08568889B2 |
Aqueous polymer compositions obtained from epoxidized natural oils
Aqueous polyurethane dispersions are made from urethane prepolymers comprising one or more polyhydroxy compounds from ketone functional molecules derived from an epoxidized natural oil. Addition of a hydrazine functional moiety to the prepolymer dispersion can further provide a crosslinking mechanism resulting in the formation of azomethine linkages in the resulting polyurethane during drying. When the ketone functional molecule is derived from levulinic acid and epoxidized vegetable oil, the resulting urethane dispersion can also be converted into a hybrid polyurethane-vinyl dispersion by adding and polymerizing one or more vinyl monomers in the polyurethane prepolymer or polyurethane dispersion. |
| US08568881B2 |
Magnetic microspheres for use in fluorescence-based applications
Microspheres, populations of microspheres, and methods for forming microspheres are provided. One microsphere configured to exhibit fluorescent and magnetic properties includes a core microsphere and a magnetic material coupled to a surface of the core microsphere. About 50% or less of the surface of the core microsphere is covered by the magnetic material. The microsphere also includes a polymer layer surrounding the magnetic material and the core microsphere. One population of microspheres configured to exhibit fluorescent and magnetic properties includes two or more subsets of microspheres. The two or more subsets of microspheres are configured to exhibit different fluorescent and/or magnetic properties. Individual microspheres in the two or more subsets are configured as described above. |
| US08568879B2 |
Polyolefin dispersion technology used for resin coated sand
A polymer-coated particulate material having: a particulate substrate; and an applied compound, wherein the applied compound coats at least 50% of the surface of the particulate substrate, and wherein, at the time of application, the applied compound includes a dispersion including: a thermoplastic polymer; and a stabilizing compound. In another aspect, embodiments disclosed herein relate to a method of forming a polymer-coated particulate material, the method including the steps of: incorporating a particulate substrate and a dispersion, the dispersion comprising: a thermoplastic polymer; a stabilizing compound; and a dispersion medium selected from the group consisting of an organic solvent, water, and combinations thereof; removing at least a portion of the dispersion medium. |
| US08568873B2 |
Pressure-sensitive adhesive for polarizing plates, polarizing plate with pressure-sensitive adhesive and production process for the same
Provided are a pressure-sensitive adhesive for polarizing plates which can apply a polarizing plate on a liquid crystal cell with good adhesion and has the characteristic that a liquid crystal display device obtained therefrom is less liable to cause light leakage even under the environment of high temperature and high humidity and which has a removability and a polarizing plate with the above pressure-sensitive adhesive and a production process for the same. The pressure-sensitive adhesive for polarizing plates is prepared by irradiating a pressure-sensitive adhesive material comprising (A) an acrylic base polymer comprising a monomer having a carboxyl group in a monomer composition ratio of 0.5 mass % or less and (B) an active energy beam-curable compound with an active energy beam and it has a storage elastic modulus (G′) of 0.3 MPa or more at 23° C. |
| US08568870B2 |
Coating film for building material
A building material and a method for coating a substrate for the building material with a coating film having a variety of functions relating to an environment such as mildew resistance, deodorization, antibacterial activity and air purification in addition to the anti-staining effect by having an excellent hydrophilicity. The method for coating the substrate for a building material comprises the steps of; coating a coating material comprising a hydrophilic polymer and a photocatalyst on the substrate, and drying the coating material to form a coating film containing the photocatalyst, wherein the hydrophilic polymer is at least one selected from the group consisting of methyl silicate, liquid glass, colloidal silica, poly(meth)acrylate, and polytetrafluoroethylene graft-polymerized with sulfonic acid, and the photocatalyst is at least one selected from the group consisting of titanium oxide coated with zeolite, titanium oxide coated silica and titanium oxide coated with apatite. |
| US08568868B2 |
Gas barrier film laminate
Disclosed is a gas-barrier film laminate having at least two gas-barrier film layers laminated via an adhesive layer, wherein the gas-barrier film layer has a substrate film, and at least one constitutive unit layer comprising an anchor coat layer and an inorganic thin film layer formed on at least one surface of the substrate film in that order, and wherein the number of the bubbles having a diameter of at least 0.5 mm and the impurities having a diameter of at least 0.5 mm existing between the gas-barrier film layers is at most 3 in total per 100 cm2. |
| US08568860B2 |
Multiwall polymer sheet comprising branched polycarbonate
Disclosed herein are multiwall sheets and methods for making the same. In one embodiment, a multiwall sheet comprises: main layers and transverse walls. The multiwall sheet comprises: a total thickness of greater than or equal to about 45 mm, a weight of greater than or equal to about 4.5 kg/m2, and/or greater than or equal to about 8 cells and a U-value of less than or equal to about 1.2 W/m2K. The multiwall sheet further comprises greater than 75 wt % branched polycarbonate resin, based upon a total weight of the multiwall sheet. |
| US08568854B2 |
Optimized fiber shapes for improved optical performance
A composite article has an article surface and may comprise a plurality of fibers at least partially embedded in a matrix. Each fiber may have at least one base surface and a pair of side surfaces. The side surfaces may be oriented in non-perpendicular relation to the base surface. The fibers may be positioned in side-by-side relation to one another such that the side surfaces of each fiber are oriented substantially parallel to the side surfaces of the immediately adjacent fibers. |
| US08568852B2 |
Artificial grass turf and infill for sports fields
The present invention relates to an artificial turf suitable for sports fields including a substrate to which first artificial grass fibers are attached and a granular infill, which is provided between the first artificial grass fibers and which is made of a recyclable synthetic material. The invention also relates to an improved granular infill for use in an artificial turf suitable for sports fields. |
| US08568847B2 |
Two-sided direct thermal label with pouch
A label adapted for direct thermal printing on both sides thereof and having a sealable pouch is described. In one embodiment, the label comprises two substrates, each substrate being coated on an outer face with a thermally sensitive coating. The inner faces of the substrates are respectively coated with an adhesive and a release material. A configuration of die cuts and perforations on the two substrates is provided to allow the label to adhere to a surface such as a package and to form a sealable pouch with respect to said surface. |
| US08568845B2 |
Heterophasic polymer composition of high stiffness
The present invention relates to a heterophasic polymer composition which comprises (i) a matrix comprising a propylene homopolymer and/or a propylene copolymer having an amount of comonomer units of less than 1.0 wt %, and (ii) an elastomeric polypropylene which is dispersed within the matrix and comprises comonomer units derived from ethylene and/or a C4 to C12 alpha-olefin; and wherein the heterophasic polymer composition has an amorphous fraction AM in an amount of 2.0 to 7.5 wt %, and the amorphous fraction AM has an amount of ethylene- and/or C4 to C12 alpha-olefin-derived comonomer units of 20 to 45 wt %. |
| US08568838B2 |
Power control for densification of one or more porous articles
A method of controlling power applied to an induction coil assembly used for densifying porous articles with a liquid matrix precursor. The control of applied power addresses dynamic changes in the electrical characteristics of the porous article being densified as it becomes denser. In particular, the power applied is controlled in accordance with changes in resonant frequency of the coupled system of the induction heating system and the porous article. |
| US08568837B2 |
Method of making golf ball with thermal sprayed layer
A method of manufacturing a golf ball with a deposited layer is disclosed. The deposited layer is not produced by a molding process, such as injection molding or compression molding. Instead, the deposition process is produced by another process, such as thermal spraying. The deposited layer may include partially fused particulate material. The deposited layer may be added to a golf ball design as one or more supplemental layers. The deposited layer may also be provided in a golf ball design as a substitute for one or more layers. A golf ball may further include a combination of one or more supplemental deposited layers and one or more substituted deposited layers. |
| US08568835B2 |
Apparatus for coloring electric wire and method thereof
An object of the present invention is to provide an apparatus and a method for injecting assuredly a given amount of a coloring agent to an outer surface of an electric wire and coloring it. An apparatus for coloring an electric wire 1 includes coloring nozzles 31. The coloring nozzles 31 each has a solenoid valve 51 to inject or stop injection of a coloring agent to an outer surface 3a of an electric wire by opening or closing the solenoid valve. A spike voltage is applied to a coil 40 of the solenoid valve 51 when the coloring agent is injected. The spike voltage is a voltage applied to the coil 40 which is necessary to open the solenoid valve 51. The spike voltage is applied to the coil 40 to open the solenoid valve 51 and stopped after a given period of time. |
| US08568834B2 |
Superhydrophilic coating compositions and their preparation
A method is provided for preparing on the surface of a substrate a superhydrophilic layer containing at least one metal oxide which method comprises calcining at elevated temperatures a cross-linked precursor film in which film the metal oxide is evenly distributed and immobilized. The precursor film is prepared by sequentially applying to the surface of the substrate a polyamine or other cationic polymer, a suspension of metal oxide and then a suitable cross linking agent. The superhydrophilic layer can be applied as a coating to a variety of substrates including metal, glass and ceramic and provides excellent dirt resistance, scratch resistance and antifogging effect. Multi-layer systems are also available using the inventive process. |
| US08568832B2 |
Method of applying a magnesium-containing powder to the surface of an aluminum or aluminum alloy substrate
Disclosed are methods of treating a metal to improve the metal's corrosion resistance. The method includes applying, to the surface of the metal, a coating which comprises magnesium powder and a binder. The present invention also relates to a coating composition that includes magnesium powder and a silane modified epoxy isocyanate hybrid polymer or prepolymer. The inventors have found that corrosion resistance (as determined by Prohesion™ exposure in accordance with ASTM D5894-96, which is hereby incorporated by reference) in excess of 3,000 hours on 2024 T-3 aluminum alloy can be achieved with the methods and coating compositions of the present invention. |
| US08568831B2 |
Solvent-borne coating composition containing acetoacyl-functional polymers
A coating composition comprising an acetoacyl-functional polymer, an organic solvent, and a crosslinking agent. |
| US08568829B2 |
System and method for printing customized graphics on caps and other articles of clothing
A cap platen to securely hold headwear, such as caps, hats, and the like, so that graphics, including custom graphics, can be printed on the cap automatically. The platen has a vise plate to support the bill of a cap and a face plate attached to the vise plate to hold the crown of cap. Arms can be attached to the vise plate or the face plate to apply a biasing force against the sides of the cap pushed the sides of the cap outwardly away from the face plate. |
| US08568828B2 |
Amorphous tin-cadmium oxide films and the production thereof
A tin-cadmium oxide film having an amorphous structure and a ratio of tin atoms to cadmium atoms of between 1:1 and 3:1. The tin-cadmium oxide film may have an optical band gap of between 2.7 eV and 3.35 eV. The film may also have a charge carrier concentration of between 1×1020 cm−3 and 2×1020 cm−3. The tin cadmium oxide film may also exhibit a Hall mobility of between 40 cm2V−1 s−1 and 60 cm2V−1 s−1. Also disclosed is a method of producing an amorphous tin-cadmium oxide film as described and devices using same. |
| US08568822B2 |
Apparatus and method incorporating discrete passive components in an electronic package
An apparatus and method for incorporating discrete passive components into an integrated circuit package. A metal layer is formed over a surface of a substrate. A layer of photosensitive material is then formed over the metal layer. Using standard photolithographic processing, a pattern is formed with the photosensitive material to expose at least one region of the metal layer. The remaining photosensitive material protects the underlying metal during metal etching. The substrate is then subjected to a metal etching process to remove the metal that is not protected by the photosensitive material. The remaining photosensitive material is then removed from each remaining area of the metal layer. The discrete passive components can then be attached to the formed metal lands. |
| US08568817B2 |
Cream substitute
Cream substitutes are described comprising: a cheese curd, a water source, and a combination of gums that provide the cream substitute the texture of a thick cream, and/or stability against oil separation. The gums may be locust bean gum and xanthan gum. The amount of cheese curd in the composition is typically not more than about 55% by weight of the total ingredients. There is also provided a process for the manufacture of a cream substitute, comprising: combining a cheese curd, a water source, and hydrated gums, to form a mixture, in which the amount of cheese curd is not more than about 55% by weight of the total ingredients, homogenising the mixture, and heating the mixture at a temperature and for a time sufficient to pasteurise the mixture to form a cream substitute. |
| US08568815B2 |
Soluble complexes of curcumin
A composition comprising a water-soluble and stable complex formed by an alkyl ether derivative of gamma-cyclodextrin and curcumin and optionally comprising non-complexed cyclodextrin, the molar ratio of curcumin to cyclodextrin being between 1:1 and 1:6, and a method of manufacturing such a composition. The water-soluble and stable complex of curcumin is useful in therapy, e.g. for treatment of cancer, leukemia, myocardial infarction, stroke, sepsis, acute lung injury, acute liver failure, acute tubular necrosis, acute pancreatitis, radiation injury and other life-threatening conditions in a human or animal subject, as well as for preserving human or animal organs, tissues or cells at a hypothermic temperature. |
| US08568814B2 |
Lanthionine derivatives
The present invention provides a variety of compounds having a CaSR agonist activity which possesses a superior kokumi-imparting function, and more particularly provides a kokumi-imparting composition, which contains the foregoing compound, and/or another substance having a CaSR agonist activity, in combination. The present invention also provides a kokumi-imparting composition which includes a lanthionine derivative and/or another substance having a CaSR agonist activity. |
| US08568813B2 |
Methods for separating fat from a material containing fat
A method includes combining ground beef with liquid that contains carbon dioxide. The ground beef and liquid are added to a vessel. The ground beef contains relative light and heavy components. The components that are predominantly lean beef will settle to the bottom of the liquid, and components that are predominantly fat will rise to the surface of the liquid. The separated components having predominantly lean beef can be removed from the liquid as a reduced fat ground beef product. The method can be practiced with any material containing fat, including plants and animals. |
| US08568809B2 |
Oil resistant packaging
Oil resistant package material and packages prepared therefrom have cyclodextrin incorporated in or adjacent to a film layer of the package to reduce the permeation of oil through the package material, and particularly out of the package. The film layer comprises a polymer that coordinates or bonds with a cyclodextrin compound in an amount sufficient to reduce the permeation of oil through the film layer as compared to a like film layer that does not contain cyclodextrin. |
| US08568808B2 |
Intercalated layered silicate
An intercalated layered silicate comprises a layered silicate and an intercalating agent sorbed between the silicate layers of the layered silicate. The amount of intercalating agent is effective to provide an average interlayer spacing between the silicate layers of at least about 20 Å. The intercalating agent has a formula selected from formulas I through VII described herein. The intercalated layered silicate may be exfoliated by mixing it with a matrix medium and adding sufficient energy to form a dispersed-particle composition. A packaging film, such as a food packaging film, may comprise the dispersed-particle composition. |
| US08568804B2 |
Muscadine compositions with improved anti-oxidant activity
Disclosed is a composition for use as an antioxidant, such as for use as an anti-aging supplement. The composition can include a muscadine (Vitis rotundifolia) pomace extract having a polyphenol content of at least 2% and trans-resveratrol from a source other than muscadine with a minimum purity of at least 5%. In an example, the ratio of muscadine pomace extract polyphenols to trans-resveratrol is in the range of 0.1/1 to 10/1 (weight to weight), thereby providing a composition with antioxidant activity. Also disclosed are methods of producing antioxidant compositions. These methods can include combining a muscadine pomace extract having a polyphenol content of at least 2% and resveratrol from a source other than muscadine with a minimum purity of at least 5% at a ratio in the range of 0.1/1 to 10/1 (weight to weight), thereby providing a composition with antioxidant activity. |
| US08568799B2 |
Isolation of a dual COX-2 and 5-lipoxygenase inhibitor from acacia
The present disclosure provides compositions and methods for alleviating inflammatory-associated diseases and conditions. These methods include administering individual and/or a mixture of multiple flavans isolated from a single or multiple Acacia genus of plants. The present disclosure also includes methods for isolating and purifying from an Acacia genus of plants a composition of flavans having dual specificity for cyclooxygenase (COX-2) and 5-lipoxygenase (5-LO) enzymes. |
| US08568798B2 |
Production and extraction of procyanidins from plant cell cultures
Provided herein are methods of making cocoa polyphenol preparations, which methods comprises harvesting cocoa polyphenols, for example, procyanidins, from the cell suspension culture. In examples of these methods, the resultant cocoa polyphenol preparation is substantially (or in some cases, completely) free of detectable caffeine and theobromine, and more generally substantially free of xanthine alkaloids. Methods of producing a cell suspension culture of cacao cells are also described, including cell suspension cultures useful for making cocoa polyphenol and, more specifically, procyanidin preparations. Theobroma and Herrania sp cell suspension cultures and cocoa polyphenol preparations made therefrom are also provided, in particular xanthine alkaloid-free (or caffeine- and/or theobromine-free) cocoa polyphenol preparations. |
| US08568795B2 |
Stabilized formulation comprising omega-3 fatty acids for skin care and/or wound care
A stabilized formulation for skin care, wound care and/or other tissue healing applications and methods for making the same is described. The stabilized formulation stabilizes omega-3 polyunsaturated fatty acids and is constituted of the omega-3 polyunsaturated fatty acids in combination with tocopherol (Vitamin E), ascorbic acid (Vitamin C), herb extract, and a fat-soluble antioxidant. Methods for making and using the stabilized formulation are also described. |
| US08568792B2 |
Metal compounds, mixed or sulphated, as phosphate binders
A mixed metal compound for pharmaceutical use is free from aluminium and has a phosphate binding capacity of at least 30%, by weight of the total weight of phosphate present, over a pH range of from 2-8. The compound is especially useful for treatment of hyperphosphataemia. The metals are preferably iron (III) and at least one of calcium, magnesium, lanthanum and cerium. A metal sulphate for pharmaceutical use is selected from at least one of calcium, lanthanum and cerium sulphate compounds and has a phosphate binding capacity of at least 30% by weight of the total phosphate present, over a pH range from 2-8. |
| US08568790B2 |
Medicinal compositions containing honey
The present invention relates to medicinal compositions containing a honey having non peroxide antibacterial activity and wherein the composition comprises from about 19% to about 80% water by weight. The use of these compositions in the treatment of eye, respiratory and ear conditions is also disclosed. |
| US08568787B2 |
Hydroxyalkylcellulose microparticles
Provided is a method of producing hydroxyalkylcellulose microparticles, the method including generating a pulse shock wave, and supplying a hydroxyalkylcellulose aqueous solution to the pulse shock wave generation region, thereby crushing and drying the hydroxyalkylcellulose aqueous solution. According to the production method, hydroxyalkylcellulose microparticles having a volume-average particle size of at least 0.1 μm but less than 15 μm are obtained. By mixing the hydroxyalkylcellulose microparticles with a principal agent and subjecting the resulting mixture to a tablet compression, a solid preparation having excellent tensile strength and disintegration properties can be obtained. |
| US08568784B2 |
Nanoparticles for delivery of active agents
Milled nanoparticles comprising a biologically active agent, at least one biopolymer and a coating containing at least one coating which is a polymer or ligand are produced using milling and coating techniques which have not previously been used for these applications. |
| US08568783B2 |
Hydrophilized substrate, dispersion, and making method
A powder is hydrophilized by treating surfaces of particles with a hydrolyzable silyl group-containing acid anhydride compound, dispersing the surface treated particles in water, adding a base, and heating the dispersion for thereby hydrolyzing the acid anhydride moiety to open its ring and neutralizing the resultant carboxylic acid with the base. The hydrophilized powder is fully dispersible in aqueous media. |
| US08568780B2 |
Pharmaceutical formulation for the production of rapidly disintegrating tablets
Pharmaceutical formulation in the form of compacts comprising A) an agglomerated excipient content composed of a1) 60-97% by weight of sugar or sugar alcohols, a2) 1-25% by weight of a disintegrant, selected from the group consisting of crospovidone, croscarmellose, sodium carboxymethylstarch and L-hydroxypropylcellulose, a3) 1-15% by weight of water-insoluble, film-forming polymers a4) 0-15% by weight of water-soluble polymers and a5) 0-15% by weight of further pharmaceutically customary excipients, the total of the components a1) to a5) being 100% by weight, B) at least one active ingredient, C) 0 to 10% by weight, based on the total amount of A) to D), of a lubricant or mold release agent, and D), if appropriate, further pharmaceutical excipients. |
| US08568770B2 |
Adhesive material containing 5-methyl-1-phenyl-2-(1H)-pyridone
There is provided an adhesive preparation containing 5-methyl-1-phenyl-2-(1H)-pyridone. The adhesive preparation is a 5-methyl-1-phenyl-2-(1H)-pyridone-containing adhesive preparation including an active medicinal ingredient-containing layer, characterized in that the active medicinal ingredient-containing layer contains an lipophilic base, a dissolving agent (except glycerin and a medium-chain aliphatic acid triglyceride), and 5-methyl-1-phenyl-2-(1H)-pyridone or medically acceptable salts thereof. |
| US08568769B2 |
Particle-containing complex porous materials
Porous materials and methods for forming them are disclosed. One method for immobilizing micro-particles and/or nano-particles onto internal pore surfaces and/or external pore surfaces of porous materials includes suspending the micro-particles and/or nano-particles in a liquid adapted to swell, soften, and/or deform either the porous materials and/or the particles, thereby forming a liquid-particle suspension. The method further includes adding the suspension to the porous materials; and removing the liquid, thereby forming the porous materials having the micro-particles and/or nano-particles immobilized on the internal pore surfaces and/or the external pore surfaces. |
| US08568765B2 |
Poly (diol co-citrate) hydroxyapatite composite for tissue engineering and orthapaedic fixation devices
The present invention is directed to a novel poly (diol citrates)-based bioceramic composite materials created using completely biodegradable and a bioceramic material polymers that may be used in implantable devices. More specifically, the specification describes methods and compositions for making and using bioceramic composites comprised of citric acid copolymers and a bioceramic material. |
| US08568759B2 |
Pesticidal compositions and methods
The present invention provides an environmentally compatible, pesticidal composition and method for the control of insect pests. The composition includes two components. The first component is a chelating agent, a metal complex of a chelating agent, and mixtures thereof, and the second component is preferably a carrier material. |
| US08568758B2 |
Corn steep liquor as a biostimulant composition
Aspects of the invention relate to organic biostimulant compositions, including, for example, formulations comprising corn steep liquor (CSL) and water. In certain illustrative embodiments, the organic biostimulant composition further comprises from one to five microbial strains as an inoculant. Another aspect of the invention relates to a method of cultivating plants that comprises the steps of preparing an organic biostimulant composition comprising water and CSL, and applying the organic biostimulant composition through a delivery system to a growth medium supporting plants. |
| US08568750B2 |
Deformed shaped particles and method for producing the same
A method for producing a deformed shaped particles comprising step of: absorbing a polymerizable vinyl type monomer contained in an aqueous emulsion in a seed particles and polymerizing an absorbed polymerizable vinyl type monomer, wherein the seed particles are a resin particles which are derived from a (meth)acrylic ester having an ester part containing at least an alkyl group with a number of carbon atoms of 3 or more and less than 6, and which have a weight average molecular weight of 150000 to 1000000 (measured by GPC: gel permeation chromatography) and the polymerizable vinyl type monomer contains 5 to 50 wt. % of a crosslinkable monomer to the entire amount of the polymerizable vinyl type monomer. |
| US08568747B1 |
Enalapril compositions
Provided herein are stable enalapril powder compositions for oral liquid formulation. Also provided herein are methods of using enalapril oral liquid formulations for the treatment of certain diseases including hypertension, heart failure and asymptomatic left ventricular dysfunction. |
| US08568742B2 |
Methods and compositions involving immunostimulatory oligodeoxynucleotides
Described is an immunostimulatory oligodeoxynucleic acid molecule (ODN) having the structure according to formula (I) wherein any NMP is a 2′ deoxynucleoside monophosphate or monothiophosphate, selected from the group consisting of deoxyadenosine-, deoxyguanosine-, deoxyinosine-, deoxycytosine-, deoxyuridine-, deoxythymidine-, 2-methyl-deoxyinosine-, 5-methyl-deoxycytosine-, deoxypseudouridine-, deoxyribosepurine-, 2-amino-deoxyribosepurine-, -6-S-deoxyguanine-, 2-dimethyl-deoxyguanosine- or N-isopentenyl-deoxyadenosine-monophosphate or -monothiophosphate, NUC is a 2′ deoxynucleoside, selected from the group consisting of deoxyadenosine-, deoxyguanosine-, deoxyinosine-, deoxycytosine-, deoxyuridine-, deoxythymidine-, 2-methyl-deoxyinosine-, 5-methyl-deoxycytosine-, deoxypseudouridine-, deoxyribosepurine-, 2-amino-deoxyribosepurine-, 6-S-deoxyguanine-, 2-dimethyl-deoxyguanosine- or N-isopentenyl-deoxyadenosine, any X is O or S, a and b are integers from 0 to 100 with the proviso that a+b is between 4 and 150, B and E are common groups for 5′ or 3′ ends of nucleic acid molecules, as well as a pharmaceutical composition containing such ODNs. |
| US08568741B2 |
Botulinum toxin for smoking cessation
The invention provides for the use of any form of botulinum toxin, or any enzymatically active derivative thereof, to cause temporary paralysis of the muscles of the lips of the mouth to promote smoking cessation. |
| US08568738B2 |
Virus-modified bacteria ghosts
The invention relates to virus-modified bacteria ghosts and the use thereof, for example, as carrier and targeting vehicles for active ingredients. |
| US08568736B2 |
Polypeptide derivatives of parathyroid hormone (PTH)
Novel parathyroid hormone (PTH) polypeptide derivatives are disclosed, as are pharmaceutical compositions containing said polypeptides, and synthetic and recombinant methods for producing said polypeptides. Also disclosed are methods for treating mammalian conditions characterized by decreases in bone mass using therapeutically effective pharmaceutical compositions containing said polypeptides. Also disclosed are methods for screening candidate compounds of the invention for antagonistic or agonistic effects on parathyroid hormone receptor action. Also disclosed are diagnostic and therapeutic methods of said compounds. |
| US08568734B2 |
Method for generating immune responses utilizing nucleic acids encoding fusion proteins comprising CD4 minimal modules and invasin polypeptides that are capable of binding to the HIV envelope and exposing cryptic neutralization epitopes
Fusion proteins comprising CD4 minimal modules that bind to HIV Env polypeptides in a non-CD4 backbone are described. Also described are complexes of these fusion proteins with Env as well as methods of diagnosis, treatment and prevention using the polynucleotides and polypeptides are also provided. |
| US08568730B2 |
Compositions for use in the treatment of chronic obstructive pulmonary diseases and asthma
The present invention provides compounds and methods for treating or preventing pulmonary diseases include COPD and asthma. In particular, the present invention provides for compounds comprising type V collagen, or tolerizing fragments thereof, for the treatment of COPD and asthma. |
| US08568728B2 |
Beta-glucuronide-linker drug conjugates
Ligand Drug conjugate compounds comprising a β-glucuronide-based linker and methods of using such compounds are provided. |
| US08568722B2 |
High affinity antibody antagonists of interleukin-13 receptor alpha 1
High affinity antibody antagonists of human interleukin-13 receptor alpha 1 are disclosed. The antibody molecules are effective in the inhibition of IL-13Rα1-mediated activities and, accordingly, present desirable antagonists for the use in the treatment of conditions associated with hIL-13Rα1 activity. The present invention also discloses nucleic acid encoding said antibody molecules, vectors, host cells, and compositions comprising the antibody molecules. Methods of using the antibody molecules for inhibiting or antagonizing IL-13Rα1-mediated activities are also disclosed. |
| US08568719B2 |
Antibodies against human respiratory syncytial virus (RSV) and methods of use
Provided herein are antibodies or antigen-binding fragments thereof that immunospecifically bind to the fusion (F) protein of Respiratory Syncytial Virus (RSV). Also provided are methods for of prevention, treatment and diagnosis of viral infection and/or the treatment of one more symptoms of RSV-mediated disease. Methods of generating antibodies that immunospecifically bind RSV F protein also are provided. |
| US08568718B2 |
Antibodies recognizing a carbohydrate containing epitope on CD-43 and CEA expressed on cancer cells and methods using same
The present invention provides antibodies (such as chimeric and humanized antibodies) specifically bind to an epitope on CD43 and CEA expressed on nonhematopoietic cancer cells. In addition, the present invention also provides use of the antibodies described herein for diagnostic and therapeutic purposes. |
| US08568717B2 |
Single domain antibodies capable of modulating BACE activity
Described are single domain antibodies with a specificity for BACE1. More specifically, described are single variable-domain antibodies derived from camelids that bind to BACE1 and are capable of inhibiting the activity of BACE1. The antibodies can be used for research and medical applications. Specific applications include the use of BACE1-specific antibodies for the treatment of Alzheimer's disease. |
| US08568715B2 |
Use of beta-1,3 (4)-endoglucanohydrolase, beta-1,3 (4)-glucan, diatomaceous earth, mineral clay and glucomannan to augment immune function
A method for the augmentation of immune function is described. The invention comprises a combination of β-1,3 (4)-endoglucanohydrolase, β-1,3 (4)-glucan, diatomaceous earth, mineral clay and glucomannan, which is fed to or consumed by mammalian or avian species in amounts sufficient to augment immune function. The invention described may be admixed with feeds or foods, incorporated into pelleted feeds or foods or administered orally to mammalian and avian species. |
| US08568714B2 |
Lys K endolysin is synergistic with lysostaphin against MRSA
Multi-drug resistant superbugs are a persistent problem in modern health care. LysK is a staphylococcal bacteriophage endolysin from the phage K. It is a peptidoglycan hydrolase enzyme that can lyse many staphylococcal strains and thus is a potent antimicrobial against S. aureus, including MRSA. Lysostaphin is a bacteriocin secreted by S. simulans to kill S. aureus, and has been shown to also be a potent antimicrobial for many antibiotic resistant strains of S. aureus. This study describes optimal reaction conditions for the recombinant His-tagged LysK protein, compares its MIC and antimicrobial activity to lysostaphin and demonstrates synergy when the two are used in combination against the MRSA USA300. |
| US08568712B2 |
Enzyme and prebiotic combinations for enhancing probiotic efficacy
This disclosure relates to enhancing growth and/or activity of lactobacilli using a prebiotic formulation which includes iso-malto oligosaccharides and α-galactosidase; and to enhancing growth and/or activity of bifidobacteria using a prebiotic formulation which includes iso-malto oligosaccharides and β-glucanase. Other combinations of fibers and enzymes are described below which also stimulate growth and activity of lactobacilli or bifidobacteria. These combinations of enzymes and prebiotics can be taken separately or added to foods, including desserts. |
| US08568710B2 |
Plant disease controlling agent and controlling method
A plant disease controlling agent containing a lactic acid bacterium which is capable of controlling plant disease and a plant disease controlling method which comprises treating a plant and/or soil with the above-mentioned lactic acid bacterium. By using the lactic acid bacterium seemingly advantageous to human health, an agricultural crop can be safely and stably produced. As the lactic acid bacterium as mentioned above, use may be favorably made of a microorganism belonging to the genus Pediococcus such as Pediococcus pentosaceus or a microorganism belonging to the genus Lactobacillus such as Lactobacillus plantarum. |
| US08568708B2 |
Tumor-specific delivery of therapeutic agents via liposomase
Clostridium novyi is an obligate anaerobe that can infect hypoxic regions within experimental tumors. We found that mice bearing large, established tumors were often cured when treated with C. novyi plus a single dose of liposomal doxorubicin. The secreted factor responsible for this phenomenon was identified and, surprisingly, proved to be a member of the lipase family. The gene encoding this protein, called liposomase, has the potential to be incorporated into diverse therapeutic methods to deliver specifically a variety of chemotherapeutic agents to tumors. |
| US08568705B2 |
Method for preparing branched functionalized polymers using branched polyol cores
A method of preparing a multiarm polymer includes reacting a branched polyol with one or more functionalizing reagents to effect substitution of an ionizable functional group or a protected ionizable functional group, Y, to form a mixture comprising (i) unsubstituted branched polyol containing no Y groups; (ii) a monosubstituted polyol comprising one Y group, and (iii) a multisubstituted polyol (e.g., a disubstituted polyol comprising two Y groups); followed by purifying the mixture to separate the monosubstituted polyol from other species Thereafter, a water-soluble and non-peptidic polymer segment is attached to the monosubstituted branched polyol at the site of at least one of the hydroxyl groups. The invention also provides purified monosubstituted branched polyols and multiarm polymers prepared by the method and polyol precursors for use in the method. |
| US08568702B2 |
Use and application of defined zwitterionic copolymer
The present invention relates to the use and application of a water-soluble or water-dispersible copolymer comprising: a) at least a monomer compound of general formula i: in which R1 is a hydrogen atom, a methyl or ethyl group; R2, R3, R4, R5 and R6, which are identical or different, are linear or branched C1-C6, alkyl, hydroxyalkyl or aminoalkyl groups; m is an integer from 0 to 10; n is an integer from 1 to 6; Z represents a —C(O)O— or —C(O)NH— group or an oxygen atom; A represents a (CH2)p group, p being an integer from 1 to 6; B represents a linear or branched C2-C12, polymethylene chain optionally interrupted by one or more heteroatoms or heterogroups, and optionally substituted by one or more hydroxyl or amino groups; X, which are identical or different, represent counterions; and (b) at least one hydrophilic monomer carrying a functional acidic group which is copolymerizable with (a) and which is capable of being ionized in the application medium; (c) optionally at least one monomer compound with ethylenic unsaturation with a neutral charge which is copolymerizable with (a) and (b), preferably a hydrophilic monomer compound with ethylenic unsaturation with a neutral charge, carrying one or more hydrophilic groups, which is copolymerizable with (a) and (b). Said polymer is a particularly good agglomerating agent and can preferentially be used in cleaning operations. |
| US08568701B2 |
Cationic synthetic polymers with improved solubility and performance in phosphate surfactant-based systems and use in personal care and household applications
The present invention is related to surfactant-based formulations comprising the polyelectrolytes and blends of such polyelectrolytes with non-cellulosic cationic polysaccharide polymers wherein the surfactant is a phosphate ester. The surfactant-based formulations exhibit improved clarity of the resulting formulations, their improved conditioning of keratin substrates, textile substrates, and hard-surface substrates, their improved deposition of dispersed phase materials onto keratin substrates, textile substrates, and hard-surface substrates, their improved lather performance, and their improved rheology in applications such as personal care and household care products and textile applications. |
| US08568698B2 |
Methods and materials for providing teeth with a white appearance
This document provides methods and materials for providing teeth with a white appearance. For example, methods and materials for contacting teeth with one or more fluorescence emitting polypeptides (e.g., a blue fluorescent protein (BFP)) to provide the teeth with a whiter appearance are provided. |
| US08568696B2 |
Grinding method for the manipulation or preservation of calcium phosphate hybrid properties
A solid state method of encouraging the physical interfacing of an organic component to a substantially crystalline inorganic component, including adding predetermined amounts of a substantially crystalline inorganic precursor and a predetermined amount of an organic precursor to yield an admixture, maintaining the admixture in a substantially liquid-free environment, and impacting the precursors together with sufficient energy to fuse the precursors into hybrid compounds. The so-formed hybrid compounds substantially retain the long range crystalline order characteristics of the substantially crystalline inorganic precursor. |
| US08568694B2 |
Nanoparticulate probe for in vivo monitoring of tissue oxygenation
A new class of micro- and nano-particulate paramagnetic spin probes especially useful for magnetic resonance imaging techniques, including electron paramagnetic resonance (EPR) and magnetic resonance imaging (MRI). The probes are lithium phthalocyanine derivative compounds. Also provided are suspensions and emulsions comprising lithium phthalocyanine derivative probes. Also provided are noninvasive methods for measuring noninvasive methods of measuring oxygen concentration, oxygen partial pressure, oxygen metabolism, and nitric oxide concentration in a specific tissue, organ, or cell in vivo or in vitro. |
| US08568685B2 |
Separation of nanostructures
The present invention generally relates to the separation of one or more populations of nanostructures from one or more other populations of nanostructures based upon differences in density. An overall mixture of very similar or identical nanostructures may be exposed to a set of conditions under which one population of the nanostructures is affected differently than the other, allowing separating on the basis of differences in density. |
| US08568679B2 |
Process for removing sulfur from a fuel gas stream additionally containing carbon dioxide and light olefins
Disclosed is a process for the removal of sulfur from a fuel gas stream that additionally contains carbon dioxide and a light olefin as well as an organic sulfur compound. The process includes hydrotreating the fuel gas stream followed by a catalytic reduction of the resulting hydrotreated fuel gas to remove the carbonyl sulfide contained therein that is yielded in the hydrotreating step as a result of the equilibrium reaction of hydrogen disulfide with carbon dioxide to yield carbonyl sulfide and water. |
| US08568677B2 |
P/S-TM-comprising zeolites for decomposition of N2O
The present invention relates to the use of a zeolite catalyst comprising at least one transition metal and in addition sulfur and/or phosphorus atoms for reducing the content of nitrogen oxides in a gas, and also to a process for reducing the content of nitrogen oxides in a gas by bringing this gas into contact with such a zeolite catalyst. |
| US08568676B2 |
Process for workup of a carbon dioxide-rich gas to be freed of sulfur components
A process for workup of an industrial carbon dioxide-rich gas to be freed of sulfur components, in which an industrial gas to be freed of sulfur components is purified by a gas scrubbing, and the laden solvent is freed of carbon dioxide and hydrogen sulfide by a regeneration to obtain at least one acid gas fraction having a relatively high content of sulfur components, and the fraction with the highest hydrogen sulfide (H2S) content is supplied to a Claus plant with downstream Claus process gas hydrogenation, and at least one carbon dioxide-laden, low-hydrogen sulfide acid gas fraction from the regeneration device, which has a reduced sulfur content compared to the fraction with the highest hydrogen sulfide (H2S) content, is combined with the hydrogenated Claus process gas to give a combined process gas stream, which is supplied to further processing or to recycling into the process. |
| US08568675B2 |
Palladium-supported catalyst composites
Provided are catalyst composites that can be used in methods for treating exhaust gas from internal combustion engines, including diesel and gasoline engines, systems including such catalyst composites and methods of using the catalyst composites to treat internal combustion engine exhaust. The catalyst composites may provide diesel oxidation catalysts and three-way catalysts. A catalyst composite is provided which a catalytic material on a carrier, the catalytic material including a palladium component dispersed on a first support comprising at least 60% by weight of a zirconia component, and one or more rare earth oxides selected from the group consisting of lanthana, neodymia, praseodymia, yttria, the first support optionally containing no more than 15% by weight ceria, and being free of alumina. Layered catalyst composites having one or more washcoats on the carrier are also provided. |
| US08568672B2 |
Agent for detoxifying discharge gas containing volatile inorganic hydride and method of detoxifying discharge gas containing volatile inorganic hydride
A detoxifying agent and a detoxifying method are provided which have a high detoxifying ability in a detoxifying treatment of a discharge gas containing a volatile inorganic hydride and generating in a semiconductor production step. A zeolite is added to a solid metal hydroxide, a solid metal carbonate, a solid basic metal carbonate, or a mixture of these compounds to thereby obtain the detoxifying agent which has the excellent ability to detoxify a discharge gas containing volatile inorganic hydride. The zeolite to be added is a synthetic zeolite selected from zeolite Y, MFI zeolite, mordenite zeolite, beta zeolite, zeolite A, zeolite X, and zeolite L or is a natural zeolite. |
| US08568670B2 |
Process for producing basic lead carbonate
A process for producing basic lead carbonate is provided. The process comprises: (1) immersing neutralization slag to obtain sodium hydroxide solution; (2) leaching lead chloride slag with the aqueous solution containing sodium chloride and hydrochloric acid, adding sodium sulfide and filtering; (3) neutralizing the filtrate with sodium hydroxide solution, filtering and washing the precipitate; and (4) converting the precipitate to basic lead carbonate with ammonium bicarbonate, crystallizing and washing. Said neutralization slag and lead chloride slag are the redundant slag from fire refining bismuth. Said process makes better use of the redundant slag from fire refining bismuth, saves resources and reduces environmental pollution. |
| US08568666B2 |
Apparatus and method for reprocessing lumened instruments
Methods and apparatus for liquid, gas, and gas plasma sterilization of items. The apparatus includes two chambers and a holder to connectorlessly secure a lumened instrument such that a first portion of the lumened instrument lies in the first chamber and a second portion of the instrument lies in the second chamber, a liquid medium contained within the two chambers, and pumping means for simultaneously increasing fluid pressure within the first chamber of said container while decreasing fluid pressure within the second chamber of the container in a reciprocating fashion. The pumping means displaces at least a total internal volume of the liquid medium through the lumen for a given highest volume of a lumened instrument during a stroke. |
| US08568659B2 |
Fiber optic device
The present invention is directed to a fiber optic device consisting of a fiber bundle having multiple legs of silica fibers, using a plurality of microspheres construct to attach target cells, for the assay of cytotoxic compounds. Each leg of silica fibers consists of twenty-five or more silica fibers treated with biotin and streptavidin treated microspheres which chemically bind the microspheres to the silica fibers. Further, the present invention is directed to the unique microspheres. The microspheres have a core, preferably alginate, with an outer surface of chitosan.The present invention is further directed to the use of the described fiber optic device to isolate, research and develop biological medicaments and diagnostic cytotoxic compounds. The fiber optic device utilizes thousands of fibers and the unique microspheres to provide a high-throughput screening device. |
| US08568658B1 |
Infant pacifier sterilization assembly
An infant pacifier sterilization assembly includes a housing that has an aperture extending through a top of the housing. An antiseptic compound is contained within the housing. The antiseptic compound is nontoxic. A valve is positioned within the aperture. The valve insertably receives a nipple on a pacifier so the nipple is submerged in the antiseptic compound. The valve is a one-way valve so the antiseptic compound is retained in the housing. |
| US08568654B2 |
Vapor-reinforced expanding volume of gas to minimize the contamination of products treated in a melting furnace
Systems and corresponding methods are described herein that provide an effective inert blanket over a metal surface (hot solid (charge) metal or molten metal) in a container such as an induction furnace. The system includes a container of metal and a system configured to delivery biphasic inert cryogen toward the metal. The delivery system may include a lance disposed at the top of the container. The lance has a hood that directs both a flow of liquid cryogen and a flow of vaporous gas toward the metal surface. The liquid cryogen contacts the metal surface, generating a volume of expanding gas over the metal surface. The vaporous cryogen creates a reinforcing vapor that slows the expansion rate of the expanding gas, localizing the expanding gas over the metal surface. |
| US08568651B2 |
Mixer for a gas cutting torch
A tip assembly for use in a gas cutting torch is provided that includes a tip and a mixer. The tip includes a tip central gas passageway and a distal orifice and the mixer includes a proximal end portion and a distal end portion. The distal end portion of the mixer is adapted for connection to the tip and the proximal end portion of the mixer defines a connecting member that removably connects the mixer to a torch head. |
| US08568647B2 |
Methods of fabricating structural elements
A method of fabricating structural elements on the surface of a component is provided. The structural elements are configured to modify flow of a fluid passing over the surface. Conveniently, the fabrication is performed using a Direct Write technique. A three dimensional element is formed by depositing material on the surface, and subsequently curing the deposited material. |
| US08568646B2 |
Compensation of actinic radiation intensity profiles for three-dimensional modelers
There is provided methods and apparatus for compensation of intensity profiles of imagers used in three-dimensional modelers. The intensity profile of the actinic radiation projected from the imager is determined by a variety of techniques, including but not limited to manually operated sensors, exposed and scanned actinic radiation-sensitive paper, and intensity profilers. Once the intensity profile of the imager is determined, each layer of the solidifiable liquid material is cured by projecting a plurality of patterns (as opposed to a single pattern) defining the two-dimensional cross-section of the part being cured. The patterns vary in duration, number, and/or shape to correlate to the intensity profile so that a single layer of selectively cured solidifiable liquid material is cured with a substantially equivalent (or otherwise controlled) amount of actinic radiation per unit of surface area to provide generally controlled and consistent part quality. |
| US08568643B2 |
Methods of manufacturing linearly expandable ureteral stents
A method includes forming an elongated member having a tubular shape. The elongated member includes a sidewall that defines a lumen. A spiral-shaped opening is formed in the sidewall such that the elongated member is configured to move between a retracted configuration and an expanded configuration along a longitudinal axis of the lumen. In some embodiments, the method further includes forming a distal retention structure. The distal retention structure can be disposed at a distal end of the elongated member and can define a lumen in fluid communication with the lumen defined by the sidewall of the elongated member. |
| US08568642B2 |
Method of fabricating a robotics skin system having integral actuation points
A method for fabricating an artificial skin system for use with a robotics assembly. The method includes providing a mold core with an exterior surface defining an inner surface of a skin system, with this surface including a plurality of mounting elements. The method includes attaching, to each of the mounting elements, an elastomeric actuation piece or point (EAP). The mold core is positioned within an exterior skin mold, and a cavity is formed between the exterior surface of the mold core and inner surfaces of the exterior skin mold that defines topography and dimensions of the skin system. The method includes filling the cavity with skin-forming material. Then, after the skin-forming material hardens to form the skin system, the method includes removing the skin system from the mold core including detaching the EAPs from the mounting elements, and the EAPs are integrally bonded within the skin system. |
| US08568641B2 |
Composite material human body support and process for making same
A human body support includes a composite material base frame having a top surface and a bottom surface, and a cover element formed from a first polymer material associated to the base frame. The support also includes a film of a second thermoplastic polymer material, which is fixedly attached to the base frame. The second thermoplastic material has an affinity for the first polymer material so that the cover element may be fixedly attached to the base frame, thereby forming an integral support. A polyurethane gel may be disposed in a recess of the base frame. The first polymer material has a thickness of 0.1 to 0.3 mm, the second material has a thickness of 0.01 to 0.025 mm, and both may be optically transparent. |
| US08568640B2 |
Method of making breast prosthesis for patients with edema
A breast prosthesis is adapted to massage a patient's chest so as to encourage circulation of interstitial lymph fluid. A breast form member has a front portion that has a shape corresponding to a human breast and a back portion. A protrusion member extends from the back portion. The protrusion member defines at least one protrusion extending outwardly therefrom. The protrusion is disposed so that when the breast prosthesis held against the patient at a preselected location, the protrusion will massage the preselected location, thereby encouraging circulation of interstitial lymph fluid. |
| US08568628B2 |
Toner preparation method and apparatus, and toner prepared thereby
A method of preparing a toner, including periodically dripping and discharging droplets of a toner constituent liquid comprising a resin and a colorant with a dripper comprising a thin film comprising plural nozzles configured to discharge the droplets, and an electromechanical converter configured to oscillate the thin film; and solidifying the droplets to form toner particles, wherein the nozzle has an aperture discharging the droplet, having a circular or an ellipsoidal cross-sectional shape and cross-sectional area smaller than a cross-sectional area of another aperture contacting the toner constituent liquid. |
| US08568627B2 |
Method for forming and modifying lenses
A lens for placement in a human eye, such as intraocular lens, has at least some of its optical properties formed with a laser. The laser forms modified loci in the lens when the modified loci have a different refractive index than the refractive index of the material before modification. Different patterns of modified loci can provide selected dioptic power, toric adjustment, and/or aspheric adjustment provided. Preferably both the anterior and posterior surfaces of the lens are planar for ease of placement in the human eye. |
| US08568624B2 |
Acrylic resin composition, and optical film comprising same
The present invention relates to an acrylic copolymer resin containing: 1) an alklyl (meth)acrylate-based monomer; 2) a (meth)acrylate-based monomer containing an aliphatic ring and/or an aromatic ring; and 3) at least an imide-based monomer or a styrene-based monomer, to a resin composition containing said acrylic copolymer resin and a resin containing an aromatic ring and/or an aliphatic ring in the main chain thereof, to an optical film comprising said resin composition, and to a liquid crystal display device comprising said optical film. The optical film according to the present invention has excellent heat resistance, optical transparency, etc. |
| US08568618B2 |
Cathode material for fluoride-based conversion electrodes, method for the production thereof and use thereof
A cathode material for fluoride-based conversion electrodes includes a matrix of graphite nanocarbon containing a dispersion of alkali metal ions, fluoride ions and metal nanoparticles with maximum particle sizes of 20 nm. Further there is provides a method for such cathode material that includes heating a metal and an organic compound during a single thermal treatment step until the organic compound is decomposed; and adding an alkali metal fluoride either before or after the thermal treatment step to the organic compound. Finally, there is provided a method of making an alkali metal ion battery, that includes utilizing the aforesaid cathode material for a fluoride-based conversion electrode in the battery. |
| US08568617B2 |
Method of producing electrode material precursor and electrode material using the electrode material precursor
Provided is a method of producing an electrode material precursor having a core-shell structure in which the particle size is extremely small and the particle diameter is uniform, and a method of efficiently producing an electrode material using the obtained precursor. The method is for producing an electrode material precursor having a core-shell structure in which an active material core is coated with polyaniline, wherein an oxidizing agent is added to a solution containing aniline and an active raw material to generate fine active material particles, and aniline is polymerized at the surface of the fine particles. An electrode material having a core-shell structure in which an active material core is coated with carbon is produced by subjecting the electrode material precursor obtained in the foregoing production method to heat treatment in a reduction atmosphere at 300 to 900° C. |
| US08568615B2 |
Full-color light-emitting material and preparation method thereof
A full-color light-emitting material and preparation method thereof are provided. A light-emitting material is following general formula compound (Y1-x-y-zAxByCz)2GeO5, wherein 0 |
| US08568614B2 |
Blue phase liquid crystal composition with reduced hysteresis behavior
The present invention relates to a blue phase (BP) liquid crystal composition that shows reduced hysteresis behavior, and to a method of reducing and/or eliminating the hysteresis behavior of a BP liquid crystal composition. Moreover, the present invention relates to a blue phase liquid crystal composition, wherein the hysteresis has been reduced or eliminated. Furthermore, the present invention relates to a liquid crystal cell comprising a blue phase liquid crystal composition, and to a liquid crystal display comprising a blue phase liquid crystal composition. |
| US08568611B2 |
Oxide coatings on lithium oxide particles
The present invention generally relates to unique coatings for use with energy storage particles, such as lithium oxide energy storage materials. The invention provides unique coatings for particles, unique particle/coating combinations, and unique methods for making coatings and/or coated particles. In one aspect of the invention, a particle is formed having a core and a coating. The particle may comprise a core having a material such as LiFePO4, and a coating. The particle may be formed, in some embodiments, by using a non-stoichiometric combination of salts or other precursors, and sintering the same to form particles. LiFePO4 may form as the core of the particle, while the remaining materials may form a coating around the LiFePO4. Typically, the LiFePO4 is crystalline while the coating is generally amorphous, and in some instances, the coating may prevent large crystals of LiFePO4 from forming. However, in other embodiments, a coating may be applied to a particle after formation of the particle to form a core/coating structure. The particles disclosed herein may have a relatively high energy capacity, and thus may find use in batteries and other energy storage devices. Other aspects of the invention relate to devices comprising such particles, methods of making such particles, kits for making such particles, methods of promoting the making or use of such particles, and the like. |
| US08568602B2 |
Method of manufacturing a magnetic read sensor having a low resistance cap structure
A method for manufacturing a magnetic sensor that decreases area resistance and decreases MR ratio of the sensor by eliminating any oxide formation in the capping layer of the sensor. The method includes forming a sensor stack having a multi-layer capping structure formed there-over. The multi-layer capping structure can include first, second, third and fourth layers. The second layer is constructed of a material that is not easily oxidized and which is different from the first layer. The sensor can be formed using a mask that includes a carbon hard mask. After the sensor stack has been formed by ion milling, the hard mask can be removed by reactive ion etching. Then, a cleaning process is performed to remove the second, third and fourth layers of the capping layer structure using an end point detection method such as secondary ion mass spectrometry to detect the presence of the second layer. |
| US08568601B2 |
Fenceless main pole definition for advanced perpendicular magnetic write head
A method for manufacturing a magnetic write head for perpendicular magnetic recording. The method includes forming a write pole using a mask that includes a hard mask layer deposited over the write pole laminate material, and a thick, physically robust image transfer layer. The image transfer layer can be a material such as AlTiO that can be patterned by a reactive ion etching process, but which also resists deformation during processing. This process allows a write pole and wrap-around trailing shield to be constructed at very narrow track widths without the mask deformation and fencing problems experienced by prior art methods. |
| US08568592B2 |
Method of biological phosphorus removal with maximum nitrogen removal in wastewater
A method for removing phosphorus and nitrogen from an activated sludge wastewater treatment system is provided consisting of one or more anaerobic zones followed by two or more activated sludge reactors operating in parallel each having independent aeration/mixing means, whereby the utilization of the influent organic carbon under anoxic conditions; and thereby, the selection of denitrifying phosphate accumulating organisms (DNPAOs) over non-denitrifying phosphate accumulating organisms (PAOs), is maximized in order to further maximize the removal of phosphorus and nitrogen in the wastewater treatment system. |
| US08568588B2 |
Apparatus for osmotic power generation and desalination using salinity difference
The apparatus for osmotic power generation and desalination using a salinity difference includes: a first osmotic membrane reactor having a first salt water position space and a third salt water position space separated by a first forward osmotic membrane; a second osmotic membrane reactor having a second salt water position space and a draw solution position space separated by a second forward osmotic membrane; a high pressure pump connected between the second salt water position space and the third salt water position space; a desalination unit obtaining fresh water by separating a draw solute from a draw solution diluted through a transmission of water in salt water of the second salt water position space by way of the draw solution position space; and a turbine driven by flow force of salt water discharged from the third salt water position space to produce electric energy. |
| US08568587B2 |
Electro-spun fibers and applications therefore
A supported nanofiber medium useful for segregating chemical species is provided by selecting a polymer, selecting a substrate; and electrospinning the polymer to form a nanofiber medium on the supporting substrate. When the substrate is a planar surface, the nanofiber medium will be a mat suitable for conducting chromatographic separation. When the substrate is a filament, the nanofiber medium is an annular mat suitable for solid phase microextraction. The nanofiber media formed may be selectively cross-linked and at least partially carbonized to carbon nanofibers. The nanofiber medium is supported on the substrate without the use of binder material. |
| US08568584B2 |
Method for control of instability in a de-ethanizer tower in fluid catalytic cracking units and delayed coking units
A method is described for controlling instability of operation in a de-ethanizer tower (13) in the gas recovery unit in fluid catalytic cracking units and delayed coking units. The method comprises the step of intervening in the de-ethanizer tower (13) when instability occurs in it, and adjusting the material balance of water in such a way that the excess of water in the feed load stream (9) is removed only as an azeotrope. The intervention is performed by introducing into the feed load stream (9) of the de-ethanizer tower (13) a volume fraction (18) of a flow of hydrocarbon, which may be either dry hydrocarbons or hydrocarbons with a low level of water content. |
| US08568579B2 |
Biosensor, biosensor chip and biosensor device
A biosensor includes a working electrode 101, a counter electrode 102 opposing the working electrode 101, a working electrode terminal 103 and a working electrode reference terminal 10 connected to the working electrode 101 by wires, and a counter electrode terminal 104 connected to the counter electrode 102 by a wire. By employing a structure with at least three electrodes, it is possible to assay a target substance without being influenced by the line resistance on the working electrode side. |
| US08568578B2 |
Electrode for electrochemical measurement apparatus and electrode for biosensor
An object of the present invention is to provide an electrode for an electrochemical measurement apparatus that is less susceptible to influence from interference substances as compared to conventional technology and an electrochemical measurement apparatus using such an electrode. A working electrode 9 (an electrode 1 for an electrochemical measurement apparatus) used in an electrochemical measurement apparatus 3 of the present invention uses an alloy containing iridium and rhenium with such a composition that selectivity for hydrogen peroxide can be obtained. |
| US08568574B2 |
Method and electrolyser for disinfectant production
A method for obtaining a disinfectant from an aqueous solution of sodium chloride by using a diaphragm electrolyser is disclosed. The method comprise channeling a fresh water flow inside a tubular cathode, separating 0.4-0.8% of the quantity of the fresh water flow and channeling the separated fresh water flow into the cathode chamber. Next, 16-20% of sodium chloride at the concentration of 0.02-1.2% is channeled to the anode chamber after a sodium chloride mixer. Fresh water flow is channeled from inside the cathode to a branch of an anode chamber in a cover-mixer of an electrolyser. The flow, originating from the cathode chamber, is discharged for utilization, wherein an anolyte flow from the anode chamber is channeled to the branch of the anode chamber. The concentration of active chlorine in the anolyte is reduced by employing a water supply to a predetermined level required of a disinfectant and the disinfectant with a pH level of 5.5-7.5 is discharged from the electrolyser. Hydrogen is channeled to an exhaust outlet from the cathode chamber. An electrolyser for use with the method is also disclosed. |
| US08568570B2 |
Use of method for one step synthesizing and immobilizing crystalline TiO2 nano-particles simultaneously on polymer material
A method of fabricating a sheet or a fabric with crystalline TiO2 nano-particles includes providing a polymer material as a support, and then synthesizing the crystalline TiO2 nano-particles with immobilizing them on a surface of the support, followed by forming the fabric or the sheet. The fabric is a textile or a nonwoven fabric. A type of the support is a fiber or a sheet type. The synthesizing of the crystalline TiO2 nano-particles is performed by occurring a sol-gel reaction under a microwave irradiation, wherein a TiO2 precursor, water, an alcohol, and an ionic liquid applied in the sol-gel reaction during the synthesizing. |
| US08568566B2 |
Method and apparatus for making absorbent structures with absorbent material
Apparatus and method for producing absorbent structures with absorbent layers with channel(s) without absorbent material, using a first moving endless surface with specific raised strip(s) and a second moving endless surface with specific mating strip(s). |
| US08568565B2 |
Silica-based sols
The present invention relates to a silica-based sol having a concentration of soluble silica of less than about 1000 mg SiO2/l, conductivity of at least about 2.0 mS/cm and S-value below about 50%. The invention further relates to a method of producing a silica-based sol comprising subjecting an aqueous alkali metal silicate solution to electrodialysis to form an electrodialyzed sol, and acidifying the electrodialyzed sol to form an acidified sol having a pH in the range of from about 5.0 to about 10. The invention further relates to silica-based sol obtainable by the process and to the use of the silica-based sol as a flocculating agent. The invention further relates to a process for producing paper which comprises providing an aqueous suspension comprising cellulosic fibers, adding to the suspension one or more drainage and retention aids comprising a silica-based sol according to the invention, and dewatering the obtained suspension to provide a sheet or web of paper. |
| US08568563B1 |
Methods of making a non-woven fire barrier mat
Methods of making the burnthrough resistant non-woven mat include forming the mat from glass fibers and at least two binders, a first binder having a vinyl component and a second binder having a strengthening component. The vinyl component may be, for example, ethylene vinyl chloride, and the strengthening component may be, for example, melamine formaldehyde. In one method, the vinyl component is added to the glass fibers by a beater addition process and the strengthening component is sprayed onto the glass fibers. The burnthrough resistant non-woven mat may be used in conjunction with an insulation blanket, and may be especially suited to use in insulating aircraft. |
| US08568561B2 |
Creped tissue sheets treated with an additive composition according to a pattern
Tissue sheets are disclosed containing an additive composition. The additive composition is applied to the tissue sheet during a creping process in a controlled manner such that the additive composition forms deposits on the sheet separated by untreated areas. In one embodiment, the additive composition is applied to a creping surface. A wet tissue sheet is then transferred to the creping surface by a topographical surface containing elevations. The elevations press the tissue sheet against the creping surface. When creped from the surface, the additive compositions transfers to the tissue sheet according to where the elevations were located on the topographical surface. |
| US08568558B2 |
Process for delignifying and bleaching chemical pulp
The delignification and bleaching of chemical pulp by a bleaching stage, in which the chemical pulp is reacted first with chlorine dioxide and, after reaction of the chlorine dioxide, is further reacted without intermediate washing with hydrogen peroxide in the presence of a molybdate or tungstate, permits the production of chemical pulp having a whiteness of at least 89.5%, having improved stability to yellowing and reduced oxidative damage. |
| US08568556B2 |
Plasma processing apparatus and method for using plasma processing apparatus
The plasma processing apparatus includes: a processing container including a metal; an electromagnetic wave source outputting an electromagnetic wave; a dielectric plate facing an inner wall of the processing container and transmitting the electromagnetic wave, which is output from the electromagnetic wave source, into the processing container; and a groove formed in an inner surface of the processing container and functioning as a propagation disturbing portion. If a low frequency microwave is supplied, the propagation of a conductor surface wave can be suppressed by the groove. |
| US08568545B2 |
Automated material removal in composite structures
A composite structure containing an out-of-tolerance area is restored using an automated material removal method. The location of an out-of-tolerance area within the structure is determined by non-destructive inspection and a volume of the structure to be removed is selected based on the location of the out-of-tolerance area. An automatic material removal tool is programmed and used to remove the selected volume of material. The volume of removed material may be is replaced by an integrated patch. |
| US08568539B2 |
Permanent magnet and method for manufacturing the same, and motor and power generator using the same
According to one embodiment, a permanent magnet is provided with a sintered body having a composition represented by R(FepMqCurCo1-p-q-r)zOw (where, R is at least one element selected from rare-earth elements, M is at least one element selected from Ti, Zr and Hf, and p, q, r, z and w are numbers satisfying 0.25≦p≦0.6, 0.005≦q≦0.1, 0.01≦r≦0.1, 4≦z≦9 and 0.005≦w≦0.6 in terms of atomic ratio). The sintered body has therein aggregates of oxides containing the element R dispersed substantially uniformly. |
| US08568538B2 |
Nanoparticle surface treatment
The present invention relates to methods and compositions for reducing damaging oxidation of metals. In particular, the present invention relates to nanoparticle surface treatments and use of nanoparticle surface treatments to reduce the damaging oxidation and corrosion of stainless steel and other alloy components in oxidating and corrosive conditions. |
| US08568537B2 |
Epitaxial wafer and method of producing the same
An epitaxial wafer comprises a silicon substrate, a gettering epitaxial film formed thereon and containing silicon and carbon, and a main silicon epitaxial film formed on the gettering epitaxial film, in which the gettering epitaxial film has a given carbon atom concentration and carbon atoms are existent between its silicon lattices. |
| US08568535B2 |
Systems and methods for exposing semiconductor workpieces to vapors for through-hole cleaning and/or other processes
Systems and methods for exposing semiconductor workpieces to vapors for through-hole cleaning and/or other processes are disclosed. A representative method includes exposing a semiconductor workpiece to a vapor, with the semiconductor workpiece having an opening extending from a first surface of the workpiece through the workpiece to a second surface facing opposite from the first surface. The opening can include a contaminant, and the method can further include drawing the vapor and the contaminant through at least a portion of the opening and away from the second surface of the semiconductor workpiece. |
| US08568534B2 |
Method for washing device substrate
The present invention provides a washing method for a device substrate, capable of sufficiently removing a resist attached to a device substrate, particularly a resist attached to fine pore portions of a pattern having a large aspect ratio.A method for washing a device substrate, which comprises a washing step of removing a resist attached to a device substrate by means of a solvent, wherein the solvent is a composition comprising at least one fluorinated compound selected from the group consisting of a hydrofluoroether, a hydrofluorocarbon and a perfluorocarbon, and a fluorinated alcohol. |
| US08568533B2 |
Multistage cellulose hydrolysis and quench with or without acid
Methods are disclosed for increasing the yields of fermentable C6 sugars from lignocellulosic biomass by using a multistage cellulose hydrolysis and quench, with or without acid. |
| US08568531B2 |
Seed holder for crystal growth reactors
A seed holder for use in a crystal growth reactor. The seed holder has a drool and a washer of outer diameter substantially the same as the drool inner diameter. A main body is disposed over the washer and drool, forming an enclosure above the washer and drool, the enclosure forming a cavity above the washer and drool. |
| US08568530B2 |
Use of cyclopentadienyl type hafnium and zirconium precursors in atomic layer deposition
Precursors suitable for chemical vapor deposition, especially ALD, of hafnium oxide or zirconium oxide, have the general formula: (R1Cp)2MR2 wherein Cp represents a cyclopentadienyl ligand, R1 is H or a substituting alkyl group, alkoxy group or amido group of the Cp ligand, R2 is an alkyl group, an alkoxy group or an amido group and M is hafnium or zirconium. |
| US08568528B2 |
Iron-doped sulfo-belitic clinker
The present invention relates to a novel iron-doped sulphoaluminate-belite clinker, a process for preparing this clinker, and also the use of the clinker for the preparation of hydraulic binder and, consequently, of grout, concrete or mortar. |
| US08568516B2 |
Biosafety cabinet filter removal devices, systems, and methods
A biosafety cabinet device includes one or more walls forming a housing, a work area contained within the housing, a filter in fluid communication with the work area for filtering fluid passing through and exiting the work area. The filter includes a primary filtration surface through which a majority of fluid being filtered by the filter passes. A filter removal device is configured to couple to the filter. The filter removal device includes a rigid barrier layer and one or more handling mechanisms adjoined with the rigid barrier layer and extending distal to the rigid barrier layer. When the filter removal device is securely coupled to the filter, the rigid barrier layer extends substantially across a non-peripheral portion of the primary filtration surface of the filter and allows passage of fluid from the work area through the primary filtration surface of the filter. |
| US08568515B2 |
Water separation systems and methods
A water separation system and method for treating multiphase hydrocarbon production streams is disclosed. The system may be employed to separate gas from the production stream, and then separate the liquid stream into its oil component and water component. A gas/liquid separator may be employed to separate a multiphase hydrocarbon production stream into a gas stream and a liquid stream. A liquid cyclone separator, positioned downstream from the gas/liquid separator, may be employed to divide the liquid stream into an oil dominated portion and a water dominated portion. The system may be used on land or on offshore platforms in locations where it is desirable to separate oil and water from hydrocarbon streams. |
| US08568505B2 |
Fertilizer suspension and method of preparation
A concentrated, homogenous, stable, water-soluble fertilizer suspension comprising: water-soluble mineral nutrients of at least nitrogen, phosphorous, potassium, calcium, and magnesium; and an organic stabilizing additive; and wherein the pourable, aqueous suspension has water-soluble mineral nutrients amounting to at least about 80 percent by weight (wt. %) of the suspension. |
| US08568501B2 |
Transportable field containment system with transparent hood
A transportable field containment system with transparent hood. The transportable field containment system being easily and rapidly deployable and transportable by virtue of its relatively small size and light weight, a collapsible transparent hood that covers the containment area over a work site on the ground, the hood including detachable or folding side panels and removable door panels. The system preferably includes an exhaust component that creates negative air pressure in the containment area under the hood, thereby drawing air that contains hazardous substances, that may be released while the work is being conducted, through one or more off-gas filters. |
| US08568498B2 |
Method for preparing a grinding composition
Composition, apparatus, and methods of composition and apparatus manufacture, for sharpening a paper shredder blade. Composition includes grinding powder, thickening agent, and additive. The thickening agent may be a white oil, an animal oil, a vegetable oil, or a stearine wax. The additive may be an antirust powder, an antiwear powder, an antistatic powder, or an antioxidation powder. The grinding composition is dispensed into a polyethylene film, and sealed to form the grinding apparatus, as a grinding sheet or a grinding packet. A method for forming a grinding sheet includes selecting the constituent materials for a grinding composition; stirring the constituent grinding composition materials; heating the constituent materials to melting; mixing the constituent materials, while melting and intermixing; cooling and packaging the grinding composition to form a grinding sheet or packet. |
| US08568497B2 |
Aggregate abrasive grains for abrading or cutting tools production
A method of forming aggregate abrasive grains for use in the production of abrading or cutting tools comprises providing abrasive core particles; coating these particles with adhesive, the adhesive comprising a binding agent and a solvent for the binding agent; separately dropping the adhesive-coated core particles onto a layer of abrasive peripheral particles and covering the dropped core particles with further peripheral particles, in such a way as to form aggregate particles, each of which comprises a core particle having peripheral particles attached to it; consolidating the aggregate particles by causing the solvent to evaporate, i.e. by letting the adhesive set. |
| US08568495B2 |
Evaporator and fuel reformer having the same
An evaporator (e.g., a small-sized high-efficiency evaporator) and a fuel reformer having the same. The evaporator has multi-stage structure (e.g., a four-stage disk structure), in which the respective disks are filled with fin structures. The first two disks through which exhaust gas passes and the second two disks through which water passes are stacked alternately with each other. Also, the first two disks are coupled with each other by a first pipe penetrating through one of the second two disks, and the second two disks are coupled with each other by a second pipe penetrating through one of the first two disks. |
| US08568492B2 |
Composition for dyeing of cellulosic fabric
A method of making a composition for spray application onto surfaces of a cotton fabric includes mixing together a wetter, a reactive dye and water to form a first solution, adding a thickener into the first solution for between about five minutes and sixty minutes to form a partial composition, and adding an alkali with the partial composition to complete the composition. |
| US08568490B2 |
Liquid detergent composition
The invention provides a liquid detergent composition containing (a) a nonionic surfactant obtained by adding ethylene oxide and an alkylene oxide with from 3 to 5 carbon atoms to a compound represented by R—OH (wherein R represents an alkyl group or an alkenyl group with from 8 to 18 carbon atoms) under a specified condition, (b) an anionic surfactant and (c) a water-miscible organic solvent in specified ratios, respectively. |
| US08568487B2 |
Patient-specific hip joint devices
A patient-specific acetabular resection guide includes a dome-shaped surface bounded by a periphery. The dome-shaped surface is a three-dimensional patient-specific surface designed to anatomically match and be received into an acetabulum of the patient, based on a three-dimensional image of a hip joint of the patient reconstructed from a medical scan of the hip joint. The resection guide includes a plurality of guiding formations defined on the resection guide and having patient-specific shapes and orientations for guiding corresponding osteotomies relative to the acetabulum for correcting hip dysplasia. |
| US08568486B2 |
Asymmetric tibial components for a knee prosthesis
An orthopaedic tibial prosthesis includes a tibial baseplate with an asymmetric periphery which promotes proper positioning and orientation on a resected tibia, while also facilitating enhanced kinematics, soft-tissue interaction, and long-term fixation of the complete knee prosthesis. The asymmetric baseplate periphery is sized and shaped to substantially match portions of the periphery of a typical resected proximal tibial surface, such that proper location and orientation is evident by resting the baseplate on the tibia. The baseplate periphery provides strategically positioned relief and/or clearance between the baseplate periphery and bone periphery, such as in the posterior-medial portion to prevent deep-flexion component impingement, and in the anterior-lateral portion to avoid undue interaction between the anatomic iliotibial band and prosthesis components. |
| US08568484B2 |
Spinal implant
A spinal implant as provided having a porous body that includes a leading end, a convex trailing end and first and second sides extending between the leading and trailing ends. At least a portion of the leading end is generally straight. The body further includes a generally dome-shaped superior surface and a generally planar inferior surface. The superior surface is convex between the leading and trailing ends and is convex between the first and second sides. |
| US08568480B2 |
Joint arthroplasty devices and surgical tools
Disclosed herein are methods, compositions and tools for repairing articular surfaces repair materials and for repairing an articular surface. The articular surface repairs are customizable or highly selectable by patient and geared toward providing optimal fit and function. The surgical tools are designed to be customizable or highly selectable by patient to increase the speed, accuracy and simplicity of performing total or partial arthroplasty. |
| US08568473B2 |
Systems and methods for enabling heart valve replacement
The present invention describes a cardiac prosthetic system (400) comprising: an anchoring conduit (200) having a harbor (415), the harbor including a first releasably engaging component (515); a temporary valve (305) and a heart valve prosthesis (420) having a second releasably engaging component (445) enabled to be securely coupled and uncoupled from the first releasably engaging component (515) of the harbor (415). |
| US08568472B2 |
Integrated heart valve delivery system
Embodiments of the present disclosure provide a delivery apparatus for delivering a prosthetic heart valve to a native valve site via the human vasculature. The delivery apparatus is particularly well-suited for advancing a prosthetic valve through the aorta (i.e., in a retrograde approach) for replacing a stenotic aortic valve. |
| US08568471B2 |
Crush recoverable polymer scaffolds
A medical device includes a polymer scaffold crimped to a catheter having an expansion balloon. The scaffold, after being deployed by the balloon, provides a crush recovery of about 90% after the diameter of the scaffold has been pinched or crushed by 50%. The scaffold has a pattern including an asymmetric closed cell connecting links connecting the closed cells. |
| US08568470B2 |
Guide wire and stent
A guide wire includes a distal core member made of a ferrous alloy which has shape memory properties and superelasticity. The ferrous alloy preferably includes substantially two phases, and has a difference of 100° C. or less between an Af point and an Ms point in a thermal hysteresis of martensitic transformation and reverse transformation. The guide wire may include a proximal core member made of an iron-containing alloy and having a higher modulus of elasticity than the distal core member. The two core members may be joined together by welding to form a core of the guide wire. |
| US08568469B1 |
Stent locking element and a method of securing a stent on a delivery system
A stent with a stent locking element and a method of securing a stent on a delivery implement, such as a catheter are disclosed. The locking element can include coupling elements capable of being releasably coupled to one another. The coupling elements may be adapted to inhibit shifting of the stent on the delivery implement. In some embodiments, the releasably coupled elements may secure the stent on the delivery implement. |
| US08568467B2 |
Trans-luminal surgical device
A device for trans-luminal delivery of a self-expanding stent or other surgical device and which is designed for rapid exchange over a guidewire has a guidewire lumen that adjacent its proximal exit port lies side -by-side with the line of the shaft of the device. A sleeve which surrounds and confines the stent has a proximal end that is shaped around the guidewire exit port to show in profile a shape reminiscent of the nose of a dolphin. In preferred embodiments, the sleeve also has a tapered distal tip that is withdrawn proximally over the length of the stent to release it, progressively, from its distal end. The configuration delivers simplicity of design, enhanced performance and reliability in use. |
| US08568462B2 |
Bone plate system with two different types of drill guides
A system for the internal fixation of a fractured bone of an elbow joint of a patient includes at least one bone plate, each bone plate having a plurality of holes and generally configured to fit an anatomical surface of the fractured bone. The at least one plate is adapted to be customized to the shape of a patient's bone. The system also includes a plurality of fasteners including at least one locking fastener for attaching the bone plate to the bone. At least one of the holes is a threaded hole. Guides for plate benders, drills, and/or K-wires can be pre-assembled to the threaded holes, and the locking fastener can lock into any of the threaded holes after the guides are removed. |
| US08568461B2 |
Percutaneous spinal implants and methods
Medical devices and related methods for the treatment of spinal conditions are described herein. In one embodiment, a method includes disposing at least a portion of a support member into a space between adjacent spinous processes. The support member defines a lumen between a proximal end and a distal end of the support member. An expandable member is inserted through the lumen of the support member such that a distal end portion of the expandable member is disposed outside a distal end of the lumen and a proximal end portion of the expandable member is disposed outside a proximal end of the lumen. The distal end portion and the proximal end portion of the expandable member are then expanded such that each of the distal end portion and the proximal end portion of the expandable member has an outer diameter greater than an outer diameter of the support member. |
| US08568460B2 |
Spine distraction implant and method
A spine distraction implant alleviates pain associated with spinal stenosis and facet arthropathy by expanding the volume in the spine canal and/or neural foramen. The implant provides a spinal extension stop while allowing freedom of spinal flexion. |
| US08568459B2 |
Apparatus for occipital-cervical fixation enabling supplemental occipital bone fixation
An apparatus for stabilization of a patient's head relative to the patient's neck joint includes an occi-cervical base member having a shaped “C”-shaped central part and first and second attachment rods respectively connected to and extending transversely from free ends of the central part. An occiput attachment has a first end slideably engaged to the central part and a flat, straight second end that extends radially outwardly relative to the first end. First and second polyaxial screw heads are adapted to be implanted in first and second occipital condyles of a patient, respectively. The first and second polyaxial screw heads are adapted to engage first and second stabilizing rods, respectively, that are placed in-line with the cervical spine of a patient and to engage the first and second attachment rods, respectively. |
| US08568451B2 |
Bone anchor for receiving a rod for stabilization and motion preservation spinal implantation system and method
A dynamic stabilization, motion preservation spinal implant system includes an anchor system, a horizontal rod system and a vertical rod system. The systems are modular so that various constructs and configurations can be created and customized to a patient. |
| US08568449B2 |
High strength suture with absorbable core and suture anchor combination
A novel high tensile strength semi-absorbable composite suture with minimized non-absorbable mass. The suture has a core made from a bioabsorbable polymer. The core is covered by a braided sheath. The braided sheath is made from an absorbable yarn and a bioabsorbable yarn. The bioabsorbable yarn is made from a least one filament of a bioabsorbable polymer. The nonabsorbable yarn is made from at least one filament of ultra high molecular weight polyethylene. |
| US08568446B2 |
Multi-chamber therapeutic cell applicator instrument
A surgical device comprises a housing, a plurality of media reservoirs, an end effector, and a pumping device. Each media reservoir is configured to receive at least one component of a tissue repair composition. The end effector is configured for insertion into a lumen to deliver a tissue repair composition into that lumen. The end effector has at least one fluid conduit and at least one orifice in communication with the fluid conduit. The pumping device is operable to urge a tissue repair composition comprising at least a portion of the contents of the plurality of media reservoirs through the fluid conduit of the end effector such that the tissue repair composition is expelled from the at least one orifice. The media reservoirs may contain medical fluid components such as viable cells and scaffold material to repair a fistula or address some other condition in a patient. |
| US08568433B2 |
Medical device having one or more active strands
The present embodiments provide an elongate medical device comprising a plurality of strands twisted in a generally helical manner to form a tubular shape having a longitudinal axis. A first strand of the plurality of strands is moveable with respect to at least a second strand of the plurality of strands. Actuation of the one or more strands may perform a medical function or actuate an associated distal component. A working lumen of the tubular member may remain unobstructed for delivery of medical components or fluids. |
| US08568432B2 |
Catheter for aspirating, fragmenting and removing extractable material from blood vessels
The invention relates to a catheter for aspirating, fragmenting and removing extractable material from hollow bodies, in particular thrombi and emboli from blood vessels, with a working head, which is arranged at the distal end of the catheter, is axially displaceable along a guide wire, independently thereof, and comprises at least one lateral opening. The catheter comprises a flexible feed screw which has a distal end and a proximal end and which can be rotated at a speed of rotation by means of a rotary drive of a drive unit remote from the working head. A flexible tube which surrounds the feed screw and is connected to the working head removes the material or the detached thrombi and emboli fragments. The feed screw is designed as a shearing cutting tool which cooperates with the opening in the working head in order to size-reduce and remove the materials or aspirated and/or detached thrombi and emboli which penetrate between the peripheral edges of the feed screw and edges of the openings. A thrust bearing is arranged between the distal end of the feed screw and the working head so as to axially support the feed screw, and is designed as a disc which can be rotated by the feed screw during operation. |
| US08568429B2 |
Transoral endoscopic gastroesophageal flap valve restoration device, assembly, system and method
The invention provides a device, assembly, and method for transoral endoscopic restoration of a gastroesophageal flap valve. The invention also provides a self-steering and self-closing tissue fixation device for tissue fixation, and an invaginator device for gripping and maneuvering tissue. The restoration device includes a longitudinal member arranged for transoral placement into a stomach, a tissue shaper carried on the longitudinal member that causes stomach tissue to assume a shape related to a gastroesophageal flap, and a tissue fixation device that maintains the shaped stomach tissue in a shape approximating a gastroesophageal flap. The tissue shaper may include a mold. The device may include the invaginator device for gripping and maneuvering esophageal tissue to aid restoration of the gastroesophageal flap, and may include the tissue fixation device. |
| US08568428B2 |
Suture system and assembly including a tubular leader having a clasp
A suture system includes a tool and a suture assembly. The tool includes a head having a proximal portion housing a needle and a distal end spaced apart from the proximal portion by a throat. The needle is movable through a needle exit port formed in the proximal portion of the head to a cavity formed in the distal end of the head. The suture assembly includes a length of suture connected to a tubular leader. The tubular leader includes an annular wall extending between an interior surface and an exterior surface, and a clasp having a first portion disposed between the interior surface and the exterior surface of the annular wall and a second portion extending out of the annular wall and adapted to secure the suture against the annular wall. |
| US08568427B2 |
Suturing device
A suturing device for suturing a portion of biological tissue includes a needle attached to a suture, a needle holder that releasably holds the needle, and a needle driver adapted to be advanced and retracted substantially parallel to a longitudinal axis of the suturing device. A distal needle holder adapted to releasably hold the needle is positioned in a distal position relative to the portion of biological tissue and a distal end of the needle driver is positioned in a proximal position relative to the portion of biological tissue. The needle is positioned in either the proximal position or the distal position. The needle driver is moved longitudinally in a first direction along a path substantially parallel to the longitudinal axis such that the needle and suture pass through the portion of biological tissue, thereby forming a suture incision through which the suture passes. By repeating the above-described processes, a series of stitches is thereby formed. |
| US08568422B2 |
Cutting needle tip for surgical instrument
A needle 20 for use with a torsional or transverse ultrasound surgical phacoemulsification instrument comprises a hollow elongated needle body 22 having a needle tip 24 at a distal end for cutting lens material. The needle tip 24 is flared in one plane to produce a substantially elliptical tip mouth 26. The elliptical tip mouth 26 has a major axis ‘X’ larger than an outer diameter of the needle body and a minor axis ‘Y’ smaller than the major axis so as to form a spade-shaped tip. The eccentricity of the elliptical tip mouth 26 can be varied, however for practical purposes it is preferred that the major axis of the tip mouth is about 1.5 to 2.5 times longer than the minor axis. The spade-shaped tip 24 provides an improved cutting action, particularly with torsional ultrasonic vibration, the cutting action being analogous to that of a spade drill bit used in woodworking. |
| US08568419B2 |
Navigation system for orthopaedic surgery
A navigation system for placing an implant in orthopedic surgery is provided, comprising an orientation apparatus and a reference apparatus. The reference apparatus comprises an anchor for fixing the reference apparatus to a predetermined feature of the subjects body and an indicator for indicating at least one reference plane or axis. The orientation apparatus comprises a number of probes for contacting a number of predetermined features of a subjects body and defining a plane. The orientation apparatus and/or the reference apparatus comprises at least one connector for connecting the orientation apparatus and the anchor such that, when connected, relative translation of the connector and the anchor along a predetermined direction with respect to the plane defined by the probes is allowed and relative rotation of the connector and the anchor about that predetermined direction is prevented. |
| US08568417B2 |
Articulating tool and methods of using
Disclosed are embodiments of an articulating tool having a head that articulates and is capable of maintaining an angle for drilling or placing a fastener into a bone. The articulating tool includes a housing, an articulating head, a rotatable drive shaft, and a driver tip connected to the distal shaft portion. The articulating tool may be constructed and arranged to move between a first position and a second position, wherein in the first position and the second position the articulating head and the rotatable drive shaft are at different angles with respect to the longitudinal axis of the housing. |
| US08568415B2 |
High speed surgical cutting instrument
A surgical cutting instrument including an outer tube having a bearing sleeve disposed within a lumen thereof, along with an inner wire assembly extending through the outer tube and the bearing sleeve. A cutting tip is connected to the inner wire assembly distal the outer tube. Conversely, a coupling chuck is connected to a proximal section of the inner wire assembly, with a housing maintaining the outer tube and the coupling chuck. When mounted to a motor, the inner wire assembly is rotated to effectuate a surgical cutting procedure at the cutting tip, with the bearing sleeve supporting the inner wire assembly relative to the outer tube during rotation. |
| US08568414B2 |
Intramedullary rod with spiraling flutes
An intramedullary rod for use in the treatment of long bone fractures includes an elongated rod extending along a longitudinal axis and including a head and a stem, at least a first transverse hole extending through the rod and a plurality of external spiral flutes located along at least a portion of the stem, wherein the elongated rod includes at least two bends along the longitudinal axis in a first plane and at least one bend along the longitudinal axis in a second plane. |
| US08568413B2 |
Bone fixation device, tools and methods
A bone fixation device is provided with an elongate body having a longitudinal axis and having a first state in which at least a portion of the body is flexible and a second state in which the body is generally rigid, an actuateable gripper disposed at one or more locations on the elongated body, a hub located on a proximal end of the elongated body, and an actuator operably connected to the gripper(s) to deploy the gripper(s) from a retracted configuration to an expanded configuration. Methods of repairing a fracture of a bone are also disclosed. One such method comprises inserting a bone fixation device into an intramedullary space of the bone to place at least a portion of an elongate body of the fixation device in a flexible state on one side of the fracture and at least a portion of a hub on another side of the fracture, and operating an actuator to deploy at least one gripper of the fixation device to engage an inner surface of the intramedullary space to anchor the fixation device to the bone. Various hub designs are disclosed that may be used in combination with other fixation device components. |
| US08568411B2 |
Electrosurgical system
An electrosurgical tool can be used for tissue dissection. The tool can include several electrodes positioned on a jaw assembly. The electrodes can be selectively connected to a power source in a cutting arrangement or a coagulation arrangement. Switching from the cutting arrangement to the coagulation arrangement can be provided by opening and closing a handle to actuate the jaw assembly. |
| US08568409B2 |
Fluid-assisted medical devices, systems and methods
Surgical devices for treating tissue are provided. Also provided are systems for treating tissue and methods of treating tissue. An exemplary surgical device has a handle, a fluid passage connectable to a fluid source, a tip portion and a distal end. The tip portion can simultaneously provide RF power and conductive fluid to tissue. The tip portion includes an electrode having a domed portion having a domed surface and a cylindrical portion having a cylindrical surface. The domed portion is located distal to the cylindrical portion and occupies at least a portion of the distal end of the surgical device. The device includes a fluid outlet opening in fluid communication with the fluid passage, the fluid outlet opening configured to provide the conductive fluid to a surface of the electrode proximal to the distal end surface of the surgical device. |
| US08568408B2 |
Surgical forceps
A forceps includes an end effector assembly having first and second jaw members. One (or both) of the first and second jaw members is moveable relative to the other between a spaced-apart position and an approximated position for grasping tissue therebetween. One (or both) of the jaw members includes a jaw frame a disposable jaw housing and an elastomeric ring member. The disposable jaw housing is releasably engageable with the jaw frame. The elastomeric ring member is removably positionable about a distal end of the jaw housing. The elastomeric ring member is configured to define a gap distance between the first and second jaw members upon movement of the first and second jaw members to the approximated position. |
| US08568406B2 |
Tracking system using field mapping
In some aspects, a method includes (i) securing multiple sets of current injecting electrodes to an organ in a patient's body, (ii) causing current to flow among the multiple sets of current injecting electrodes to generate a field in the organ, (iii) in response to current flow caused by the multiple sets of current injecting electrodes, measuring the field at each of one or more additional electrodes, (iv) determining expected signal measurements of the field inside the organ using a pre-determined model of the field, and (v) determining a position of each of the one or more additional electrodes in the organ based on the measurements made by the additional electrodes and the determined expected signal measurements of the field. |
| US08568402B2 |
Thermal feedback systems and methods of using the same
A system for providing feedback during an electro surgical procedure on a target tissue is provided. The system includes an electrosurgical energy source; an electrode probe assembly connected to the electrosurgical energy source, wherein the electrode probe assembly includes at least one electrode assembly having a needle configured to deliver electrosurgical energy to the target tissue; at least one thermal feedback assembly connected to the electrosurgical energy source, wherein each thermal feedback assembly includes at least one temperature sensor assembly; and a hub configured to selectively support the electrode probe assembly and each thermal feedback assembly such that the needle of the electrode probe assembly and each temperature sensor assembly of each thermal feedback assembly are proximate one another when disposed proximate the target tissue. |
| US08568401B2 |
System for monitoring ablation size
A system for monitoring ablation size is provided and includes a power source including a microprocessor for executing at least one control algorithm. A microwave antenna is configured to deliver microwave energy from the power source to tissue to form an ablation zone. An ablation zone control module is in operative communication with memory associated with the power source. The memory includes one or more data look-up tables including one or more electrical parameters associated with the microwave antenna. The one or more electrical parameters corresponding to an ablation zone having a radius. The one or more electrical parameters include a threshold value, wherein when the threshold value is met the power source is adjusted to form an ablation zone of suitable proportion. |
| US08568400B2 |
Methods and apparatus for smart handset design in surgical instruments
An electrosurgical instrument is provided which includes a housing and an electrocautery blade supported within the housing and extending distally. The housing has a treatment portion attached and defining a chamber therein for retaining an activation circuit and a control circuit. The activation circuit is operably coupled to at least one activation element that is activatable to control the delivery of electrosurgical energy from a generator to tissue proximate the treatment portion. The control circuit includes a microprocessor to enable bidirectional communication between the electrosurgical instrument and the generator relating to usage information of the electrosurgical instrument. The usage information includes serial number of the electrosurgical instrument, instrument type, number of times the electrosurgical instrument has been activated, overall time the electrosurgical instrument has been used, operating parameters of the at least one activation element during each activation, operational status of the treatment portion during each activation, and power settings. |
| US08568397B2 |
Induction sealing
An end effector assembly for use with an electrosurgical instrument is provided. The end effector assembly has a first jaw member having a support base and a sealing plate formed from a ferrous material. The end effector assembly also has a second jaw member including a support base, an electrical jaw lead and a sealing plate coupled to the electrical jaw lead. The sealing plate includes a first layer formed from a non-stick material and a second layer having a coil formed thereon. |
| US08568393B2 |
Computer guided patterned laser trabeculoplasty
A system and method of performing therapy on target eye tissue. A light source produces a beam of light, and a scanning device deflects the light beam to produce an pattern of the light beam. An ophthalmic lens assembly includes a mirror for reflecting the light beam pattern onto the target eye tissue. The mirror is rotatable to angularly align the light beam pattern to the target tissue. Control electronics control the scanning device to apply the light beam pattern onto the reflective optical element at first and second angular orientations separated by a predetermined angle RA. The predetermined angle RA is set such that light beam patterns applied to the target tissue at the first and second angular orientations, which are also angularly aligned to the target tissue through rotation of the mirror, automatically are adjacently abutting to each other on the target tissue. |
| US08568387B2 |
Systems and methods for removal of urine
The present invention provides an arrangement (200) adapted for enhanced continuous flow of urine in a catheterized patient, the arrangement comprising a catheter tube (204) having an inner diameter of less than six millimeters, said tube having an inner surface which is hydrophobic at least along a first segment thereof and being adapted to provide a continuously negative fluid pressure therein. |
| US08568385B2 |
Device and method for restricting blood flow to fibroids
A method of treating tissue comprises introducing into a hollow organ a support device and, after insertion, arranging the support device into a non-yielding configuration substantially filling the hollow organ and substantially preventing walls of the hollow organ from moving inward in combination with inducing contraction of the hollow organ around the support device to cut off blood flow through at least a portion of the walls of the hollow organ and removing the support device after blood flow has been cut off for a predetermined time. A system to treat tissue comprises a support device which, in a first configuration, is sized and shaped for insertion into a hollow organ and an expansion mechanism for expanding the support device from the first configuration to a second configuration in which the support device substantially fills the hollow organ providing a non-yielding support so that, if the hollow organ is contracted around the support device, blood flow through at least a portion of a wall of the hollow organ is cut off. |
| US08568381B2 |
Tampon and a method of producing a tampon
A tampon is proposed, with an insertion end and a rear end, made from a pressed absorbent strip (2) and a withdrawal string (3) running out of the rear end. In order to achieve short production times during manufacture of the tampon, the withdrawal string (3) is placed around the strip (2) in the shape of a loop 4, and the strip (2) is provided with a fold (16, 17) at each side of the loop (4).In terms of a method suitable for producing a tampon, the following steps are proposed: a) cutting the absorbent strip (2) to size, b) placing a withdrawal string (3) around the strip (2) in the shape of a loop (4), c) pressing the strip (2) between jaws (7) which can be moved towards one another forming a fold (16, 17) in the strip (2) on each side of the loop (4). |
| US08568379B2 |
Absorbent article comprising a design field
An absorbent article may comprise a web comprising at least one continuous layer that forms a portion of a backsheet and a portion of laterally opposing side flaps. The web may be folded laterally inward to form the side flaps. The article may further comprise an exteriorly viewable first design field disposed on a surface of a backsheet, interiorly viewable second and third design fields disposed on a surface of first and second side flaps, respectively, viewable fourth and fifth design fields disposed on a surface of first and second abdominal stretch panels, respectively, and an absorbent assembly. |
| US08568378B2 |
Method of packaging an absorbent article and attaching the absorbent article to an undergarment
A method of individually packaging an absorbent article and attaching the absorbent article to an undergarment including the steps of providing a tri-folded absorbent article having two end portions and an intermediate portion, providing a pouch containing the tri-folded absorbent article, opening the pouch to thereby expose a garment-facing surface of the intermediate portion of the absorbent article prior to exposing a garment facing surface of either of the end portions of the absorbent article. |
| US08568377B2 |
Elastic composite for a disposable absorbent garment
An elastic composite is provided in a disposable absorbent garment such as a diaper or training pants. The elastic composite has a base layer, a top layer, and an elastic construction disposed therebetween. The elastic construction includes a plurality of spaced apart (e.g. generally equally spaced apart) elastic elements (e.g. strands or threads) that are aligned in a generally cross machine direction and in generally parallel relation. Further, the top and base layers define a first longitudinally extending side edge and a second longitudinally extending side edge between which, the elastic construction is disposed. The elastic composite further includes an elasticized region, wherein the elastic construction is disposed, a first non-elasticized region disposed between the first side edge and the elasticized region, and a second non-elasticized region disposed between the second side edge and the elasticized region. |
| US08568373B2 |
Medical elongate member housing tool and medical elongate member housing tool assembly
An elongate member housing tool assembly includes a distal end side tubular member disposed on the distal end side and a proximal end side tubular member disposed on the proximal end side, which accommodate an elongate member, and a liquid inlet port to which a liquid supplying tool for supplying liquid into the distal end side tubular member is removably connected and which is provided on the distal end side tubular member. The distal end side tubular member and the proximal end side tubular member are wound spirally, and the proximal end of the distal end side tubular member and the distal end of the proximal end side tubular member are disposed in a spaced relationship from each other. A distal portion of the guide wire is accommodated in the distal end side tubular member, except possibly the most distal portion of the elongate member. |
| US08568367B2 |
Needle assemblies for wet/dry automatic injectors
An automatic medicament injector having a compartment for a dry medicament component and a compartment for a wet medicament component. The two compartments are separated by a seal structure that converts from a sealing condition to a mixing condition when the device is activated. The seal structure includes a wiper that scrapes the interior walls in the dry component compartment to prevent the dry component from accumulating at the seal/glass interface. A tapered insert funnels the mixed medicament components to an attached needle assembly, but can be removed when the device is filled. A filter is provided between the medicament compartments and the needle assembly. A chamber between the filter and the needle allows for better flow through the filter. An actuation assembly drives the seal structure into the mixing condition and forces the mixed medicament through the needle and into the user. |
| US08568366B2 |
Reservoir module for an administering apparatus
A reservoir module for an administering apparatus, the reservoir module including a rotational block which permits the rotational dosing movement in a first rotational direction and blocks the rotational dosing movement in a second rotational direction, wherein the rotational block includes at least one first rotational stopper and at least one second rotational stopper, the first rotational stopper and the second rotational stopper abut against one another in the end position of the dosage setting member, wherein the dosage setting member is moved away from the translational stopper by the permitted rotational dosing movement. |
| US08568363B2 |
Frozen compositions and methods for piercing a substrate
Certain embodiments disclosed herein relate to compositions, methods, devices, systems, and products regarding frozen particles. In certain embodiments, the frozen particles include materials at low temperatures. In certain embodiments, the frozen particles provide vehicles for delivery of particular agents. In certain embodiments, the frozen particles are administered to at least one biological tissue. |
| US08568362B2 |
Surgical access device with sorbents
The present invention generally provides methods and devices for removing fluid from a surgical instrument. Surgical access devices and seal systems are generally provided having one or more valves or seal assemblies to create a closed system between the outside environment and the environment in which the surgical access device is being inserted. The devices of systems can also include a fluid remover in the form of a sorbent element, a scraper element, a wicking element, or any combination thereof that is configured to remove fluid from a working channel of the device or system and/or from a surgical instrument inserted therethrough. |
| US08568360B2 |
Programmable implantable pump design
A programmable implantable pump is disclosed. The pump includes an implantable pump and a hermetically sealed module. The module provides for varying flow rates of fluid being dispensed from the pump or may provide for a constant flow rate of such fluid. In the case of varying flow rate capabilities, the module preferably includes one or more sensors to determine information relating to the pressure of the fluid, electronics for analyzing the pressure information and determining the flow rate of the fluid, and a mechanism for physically altering the flow rate. Methods of dispensing a medicament to a patient utilizing such a system are also disclosed, as are variations of the pump system. |
| US08568359B2 |
Autoinjector
The invention relates to an autoinjector (1) comprising: a housing (30, 30a, 30b), a container movable within said housing between an initial position and an insertion position, said movement being prevented when the container is in its passive state, and permitted when the container is in its active state, and a safety shield (40) movable with respect to said housing between a first position and a second position, said movement placing the container in its active state, first retaining means (61, 52) for maintaining said container in its passive state, characterized in that it comprises first deactivating means (50, 51), capable of rotating with respect to said first retaining means from a first position, in which said first retaining means maintain said container in its passive state, to a second position, in which said first retaining means allow the passage of said container in its active state, said rotation being caused by movement of said safety shield from its first position to its second position under distal pressure exerted on said housing. |
| US08568358B2 |
Device for automatic delivery of successive doses of product
The invention relates to a device (1) for delivering two predetermined doses of a product (3), comprising: —a container (2) for containing said product, said container having a distal end (2d) through which the product is delivered under the distal pressure of a piston, —a pusher (7) movable with respect to said container for causing said piston (4) to move in the distal direction from an initial position, in which none of said product has been expelled to a first position, in which a first dose of said product has been expelled, and to a second position, in which a second dose of said product has been expelled, —a holder body (15) receiving said container and said pusher (7), —biasing means (22) for urging said pusher (7) in the distal direction, from the initial to the first position, and to the second position, —first and second retaining means (9, 11, 19) for maintaining said pusher (7) in said initial position, and in said first position, —first and second actuation means (18) to deactivate said first and second retaining means (9, 11, 19), characterized in that said first and/or second actuation means (18) are at least rotationally displaceable, said rotation causing at least part of the deactivation of said first and/or second retaining means (9, 11, 19). |
| US08568353B2 |
Low profile agent delivery perfusion catheter having a funnel shaped membrane
An agent delivery catheter and method configured to deliver an agent to an inner surface of a patient's body lumen wall by forming a funnel shaped agent containment chamber around at least one portion of the inner surface of the body lumen wall, while minimizing ischemic conditions during the procedure. |
| US08568351B2 |
Nursing device
A nursing device for feeding infants with a cleft lip and/or cleft palate includes a nipple body and a tube operatively attached at one end to a pump for pumping liquid and operatively attached at the other end to the nipple body. The tube passively regulates the amount of liquid being pumped, ensuring that the infant can feed with minimal mess from the infirmities of cleft lip and/or cleft palate. The nipple body includes an outer flange and a cap for sealing engagement with the top of a nursing bottle. A shield can be used to cover the nipple body, which serves to protect and form a temporary reservoir for the liquid dispensed through the nipple body. |
| US08568347B2 |
Apparatus for making extracorporeal blood circulation available
The present invention relates to an apparatus for making extracorporeal blood circulation available, in particular a heart-lung machine, comprising a venous connection and an arterial connection, between which a blood reservoir, a blood pump and a bubble detector for the detection of air bubbles are provided, with, downstream of the bubble detector, an arterial line leading to the arterial connection via an arterial clamp and a bypass leading via a bypass clamp back into the blood reservoir which is connected to a pump extracting air from the blood reservoir. In addition, the present invention relates to a method of operating such an apparatus. |
| US08568339B2 |
Single element ultrasound transducer with multiple driving circuits
Apparatus for generating high intensity acoustic beams, the apparatus comprising: a piezoelectric transducer characterized by a plurality of harmonic resonant frequencies of vibration; and at least one driving circuit connected to the transducer that is controllable to excite at least two vibrations of the transducer at different harmonic vibration frequencies of the vibrator, which vibrations generate a high intensity acoustic beam for each of the harmonic frequencies. |
| US08568337B2 |
Medical measuring device and method
A subsurface wound measuring device and method are provided for measuring a subsurface wound or cavity of a patient, the device including a flexible strip having a first and second section, said sections having a first and second ends respectively with an intermediate bend being located between the first and second ends. The first end is adapted for being located internally to a patient, the second end being adapted for being located externally to the patient. The first and second sections have generally concave shaped cross-sections with measuring indicia being located along at least one of the sections. The device also optionally includes a measuring strip and a receiver mounted on the second end for receiving the measuring strip, where the measuring strip and the flexible strip form complementary structure for measuring a subsurface wound or cavity. |
| US08568336B2 |
Non-invasive device for diagnosing gastroesophageal reflux
The present invention provides compositions and methods useful in the diagnosis and management of Gastroesophageal Reflux. Specifically, the inventions provide a device and methods of using the device for accurately, quantitatively, and non-invasively diagnosing Gastroesophageal reflux disease (GERD) in both patients at risk for GERD and patients demonstrating reflux-like symptoms. In particular, the inventions relate to detecting and analyzing upward esophageal movements in patients, such as human infants, children, and adults. |
| US08568335B2 |
Biopsy device with vacuum assisted bleeding control
A biopsy device and method are provided for obtaining a tissue sample, such as a breast tissue biopsy sample. The biopsy device includes a disposable probe assembly with an outer cannula having a distal piercing tip, a cutter lumen, and a cutter tube that rotates and translates past a side aperture in the outer cannula to sever a tissue sample. The biopsy device also includes a reusable hand piece with an integral motor and power source to make a convenient, untethered control for use with ultrasonic imaging. External vacuum holes along the outer cannula (probe) that communicate with a vacuum and cutter lumen withdraw bodily fluids while a hemostatic disk-shaped ring pad around the probe applies compression to an external hole in the skin and absorbs fluids. |
| US08568334B2 |
Core biopsy device
A core biopsy device comprises a cutting cannula provided at a distal end with a helical excising blade. The cutting cannula can be rotated within a tissue mass so that the helical excising blade can excise a biopsy sample from the surrounding tissue. |
| US08568330B2 |
Composite human physiological stress index based on heart beat and sleep and/or activity history data including actigraphy
Systems and methods are provided for providing a composite stress index representing a quantified stress level that an individual may be experiencing or may have experienced during a time interval of interest. The composite stress index is determined based on a combination of heart beat data representative of cardiac activity of the individual during the time interval of interest and one or both of: sleep history data comprising one or more sleep onset times and one or more awakening times during the time interval of interest; and physical activity history data representative of gross motor activity of the individual during the time interval of interest. |
| US08568329B2 |
Baseline drift canceling method and device
An embodiment of a baseline drift canceling method is provided. The method removes a baseline drift signal from a bioelectric signal, and includes the steps as follows: delaying the bioelectric signal by an analog time delay circuit to generate a first bioelectric signal; according to the bioelectric signal to generate a baseline drift signal; and acquiring a second bioelectric signal according to the first bioelectric signal and the baseline drift signal. |
| US08568325B2 |
Method and apparatus for controlling power of an ultrasound system
A medical imaging system with a scanning subsystem configured to acquire imaging data is provided. Also provided is a controller configured to selectively control power to at least one component of the system based on a mode of operation of the scanning subsystem. |
| US08568324B2 |
Systems and methods for mechanical translation of full matrix array
An ultrasonic transducer assembly (10) for diagnostic imaging is provided. The ultrasonic transducer includes an elongated housing (12) that is configured and dimensioned to accommodate applicable anatomical constraints. The assembly includes a sensor assembly (20) that includes a two-dimensional matrix array of transducer elements (22) and a translation mechanism (32) to physically translate the two-dimensional matrix array of transducer elements (22) through a field of view of approximately 140 degrees by 80 degrees. An articulation control mechanism (38) allows a clinician to move the tip (14) of the ultrasonic transducer (10) into a desired imaging position, e.g., for fetal imaging. |
| US08568322B2 |
Head for imaging and treating organs of living organisms and production method thereof
The invention relates to a head for imaging and treating an organ or tissue of a living organism, which is suitable for the treatment of thyroid or prostate tumors. The head comprises: an ultrasound probe for emitting waves or radiation in order to supply an image of the tissue or organ to be treated and a treatment mechanism for treating the tissue or organ locally, where the treatment mechanism emits waves or radiation to treat same. The ultrasonic probe divides the treatment mechanism into two parts that are substantially symmetrically identical in relation to the ultrasonic probe. |
| US08568321B2 |
Ultrasonic diagnostic apparatus and control method thereof
An ultrasonic diagnostic apparatus that performs an image signal generating operation with respect to an ultrasound signal transmitted to and reflected from a target through a host computer and a control method thereof are provided. The ultrasonic diagnostic apparatus includes a probe including at least one transducer to transmit an ultrasound signal to a target, to receive the ultrasound signal reflected from the target, and to transduce the received ultrasound signal into an analog signal, an analog-to-digital (A/D) converter to convert the analog signal output from the probe into a digital signal, a compression unit to compress the digital signal output from the A/D converter, and a host computer to decompress the digital signal compressed by the compression unit and to perform beamforming. |
| US08568315B2 |
Systems and methods for monitoring health and delivering drugs transdermally
The present invention pertains to a system and method for transdermal sampling, comprising: at least one sampler for retrieving and transferring at least one analyte obtained transdermally from the skin of a subject; at least one detector system for identifying and quantifying said at least one analyte; and at least one logic module for (i) receiving and storing input data from said at least one detector, (ii) relating the input data to other data obtained from the subject, (iii) displaying output information, (iv) transmitting the output information to another system, and (v) controlling the operation of said at least one sampler and at least one detector. |
| US08568312B2 |
Electro diagnostic functional assessment unit (EFA-3)
An Electro Diagnostic Functional Assessment Unit (EFA-3) that is designed to wirelessly monitor muscle group activity and to provide treatment for humans and animals. The muscle groups include the body, fascial, cervical, thoracic, upper and lower extremities, lumbosacral, bladder, cardiac, and rectal. In large animals the muscle groups include torso, legs, neck and face. The EFA-3 simultaneously correlates the muscle activity EMG with cardiac activity, nerve activity, heart rate, blood flow and brain activity with range-of-motion, grip and pinch assessment and a functional assessment in humans. The EFA-3 is operated by proprietary software (78) which provides testing protocols by utilizing a set of wireless sensor(s) (14-40) that are interchangeable and rechargeable. The treatment includes ultrasound, heat, cold, massage and electrical stimulation. |
| US08568311B2 |
Display enhanced testing for concussions and mild traumatic brain injury
Cognitive assessment systems and methods that provide an integrated solution for evaluating the presence or absence of cognitive impairment. The present invention is used to test cognitive functions of an individual including information processing speed, working memory, work list learning and recall, along with variations of these tasks. Immersive and non-immersive systems and methods are disclosed. Testing and results feedback using the present invention may be completed in real time, typically in less than 15 minutes. |
| US08568310B2 |
Sensor fusion for activity identification
A mobile device monitors accelerations using one or more inertial sensors. A user activity is identified based on the accelerations. A first estimation is made of a user activity statistic associated with the user activity based on the accelerations. Location information is obtained by one or more location based sensors. A second estimation is made of the user activity statistic based on the location information. The user activity statistic is calculated based on the first estimation and the second estimation. |
| US08568309B2 |
Controlling diabetes with a cellular GPRS-linked glucometer-pedometer
The Cellular GPRS system includes a cellular-based Glucometer (CBG) for blood glucose monitoring, a pedometer for exertion measurement, combined with user-entered dietary or other diabetes-relevant information. Data from all inputs is transmitted over a cellular network, using a GPRS or other wireless link. The data is preferably stored in the device prior to being transmitted wirelessly over the cellular airway to a central computer server. The remote computer server will evaluate the data received and respond with a data packet (making recommendations on further glucose measurement, exercise, diet, insulin requirements or other). |
| US08568298B2 |
Propellable apparatus and related methods
Propellable apparatus, assemblies and related methods including a self-enclosed member are disclosed. The self-enclosed member can include an inner surface at least partially defining an enclosed region, and an outer surface that turns outwardly to engage a cavity or lumen wall in addition to turning inward to at least partially encompass a central region defining a longitudinal path. The apparatus can include an internal drive mechanism engageable with the outer surface of the self-enclosed member to provide relative movement between the self-enclosed member and the cavity or lumen wall. A tapered member, positioned on the apparatus adjacent an end of the self-enclosed member, can provide a size transition between an outer surface portion of the self-enclosed member and an outer surface of a payload insertable within the central region. In some examples, one or more reinforcing members can be integrated within the self-enclosed member for increased durability and rotational use. |
| US08568293B1 |
Surgical spay and neuter assist platform system
In accordance with one embodiment a surgical device consisting of a rigid frame with a spindle straddling the lateral members and coupled with a ratcheting traction unit for the purpose of anchoring an organ and, to apply controlled incremental traction to the tissues connecting the organ to the body enabling exposure of a working length of the tissue and its associated structures for the application of ligatures etc. |
| US08568292B2 |
Fecal incontinence device, system and method
A device for treating fecal incontinence in a subject is provided. The device includes a plug configured for positioning mostly within an anal canal of the subject. |
| US08568289B2 |
Apparatus and method for monitoring and controlling extracorporeal blood flow relative to patient fluid status
A system and method for controlling extracorporeal blood flow in a patient. The system includes a blood pump having a rotor, a plurality of rollers carried by the rotor and a pump chamber extended in tension about the rollers. A sensor measures an operating parameter of the blood pump and a controller, coupled to the sensor, calculates the flow efficiency of the blood pump based on the measured operating parameter. The controller is further configured to display the flow efficiency on the display device, and the operation of the blood pump is adjusted based on the flow efficiency when necessary. |
| US08568288B2 |
Slide device, mechanical seal, rotary device, pump and auxiliary artificial heart system
Provided is a slide device which can reduce a frictional force more than a conventional slide device when used in an aqueous liquid containing a blood component. In a slide device which includes: a fixed-side slide member having a slide surface; and a rotary-side slide member having a slide surface, the slide device being used in an aqueous liquid containing a blood component in a state where the slide surface of the fixed-side slide member and the slide surface of the rotary-side slide member face each other in an opposed manner, at least one of the fixed-side slide member and the rotary-side slide member is formed of a member which is made of a material which contains silicon and has hydrate of silicon oxide on the slide surface thereof. |
| US08568286B2 |
Methods to position therapeutic agents using a magnetic field
A system for controlling the location of a therapeutic agent administered to a mammal is provided. The system employs a device that is capable of generating a magnetic field and a therapeutic agent labeled with a magnetically responsive moiety. Methods which employ the device and the therapeutic agent are also provided. |
| US08568284B2 |
Expandable brachytherapy device
A method for brachytherapy in a lumpectomy cavity of a breast including, positioning a distal end of a brachytherapy device within the cavity, expanding an expandable surface portion located between proximal and distal ends of the device within the cavity, the source lumen tubes defining a curved configuration within the cavity; and positioning a source of radiation sequentially within one or more source lumens of the source lumen tubes according to a brachytherapy treatment plan. The device includes an inner tube, and a plurality of source lumen tubes located around the inner tube and including distal ends secured together with the inner tube at the distal end disposed within the body cavity, the source lumen tubes comprising proximal portions sufficiently long to extend outside the breast. |
| US08568281B2 |
Strength training workout bench
A rectangular workout bench with removable legs for use directly on the floor or raised on legs 12, 13, 108 has an inflatable flexible air filled plastic material cushion 2 work out area allowing a person to lay on for physical therapy, strength training and balance. The rectangular shape allows spine and neck support while the instability of the air filled cushion 2 allows muscles to activate. Beginners use the workout cushion 2 directly on the floor and advanced workouts are on the elevated bench with accessible footrests. |
| US08568280B2 |
Separable weight adjustable medicine ball
The present invention is a separable weight adjustable medicine ball, which can be used in a variety of exercise routines. The present invention is primarily comprised of two pieces, which can either be separated to perform exercises that involve dumbbells or push-up handles or be combined to perform exercises that involve a medicine ball. The present invention allows a user to incrementally increase the exercising load with a plurality of weights. The plurality of weights is separated between the two pieces and held in place with a pair of weight supports. The plurality of weights is secured on the pair of weight supports with a pair of collar clamps. The collar clamp is an user-friendly device that can be opened by squeezing the sides of the collar clamp and can be closed by releasing the sides of the collar clamp. |
| US08568274B2 |
Hydraulic pressure supply control apparatus for automobile
In one embodiment, a hydraulic pressure control circuit (4) of an automatic transmission includes a mechanical oil pump (MOP) and an electrical oil pump (EOP). The discharge side of the electrical oil pump (EOP) is caused to be in communication with the direct upstream side of a hydraulic pressure servo of a first clutch (C1) via a shunt hydraulic pressure supply passage (430). At the time of idle reduction, a linear solenoid (411) on the upstream side of the first clutch (C1) is caused to enter a forced closure state, thus preventing oil from the electrical oil pump (EOP) from flowing to a manual shift valve (410) side. |
| US08568271B2 |
System and method to prevent shift hunting in a powertrain
A method for preventing shift hunting in a powertrain including an engine and a transmission having a variator, a first gearset, and a second gearset is disclosed. The method includes operating the engine at a first substantially constant speed, detecting a shift condition, and operating the engine at a second substantially constant speed as a function of detecting the shift condition. The second speed is different than the first speed. |
| US08568269B2 |
Linearly adjustable torque transmission systems and methods
Linearly adjustable torque transmission systems and methods for a power driven machine are provided. The system can include a first wheel adapted to be rotatably driven. The system can further include a second wheel positioned proximate the first wheel that can engage the first wheel such that rotational movement of the first wheel can impart rotational movement to the second wheel. The second wheel can be coupled to a shaft with bearings between the second wheel and the shaft such that the second wheel is movable along the shaft in a lateral direction while the second wheel is coupled to the shaft wherein rotational movement of the second wheel rotationally moves the shaft. |