Document Document Title
US08525064B2 Electric discharge machine and method of producing nozzle body using the same
An electric discharge machine to process a work piece includes a plurality of electrodes, and a plurality of discharge power supply units. The plurality of electrodes generate a plurality of discharges with the work piece, respectively. The plurality of discharge power supply units apply voltages for the plurality of electrodes, respectively and independently.
US08525058B2 Snorkel for venting a dome switch
To prevent debris from entering the volume between a dome and contacts of a dome switch, a dome can include a channel providing a remote path through which air can be vented. In particular, the channel can extend from the dome to a location within an electronic device that is known to be or expected to be contaminant free (e.g., a region of the device that does not include any interfaces communicating with the device environment). The channel can be defined from components of the dome switch including, for example, as a channel bound by spacer walls between a flex circuit and a film layer. The channel can include an opening for venting the dome switch. In some embodiments, the dome switch can include a protective film applied over the opening in the channel. The protective film can be selected to allow air to flow through, but to prevent contaminants or particles from reaching the channel opening.
US08525055B2 Pressure response membrane
Pressure response devices, systems, and associated methods. The pressure response device includes a flange portion, a central portion, and an angled frustum portion provided between the flange portion and the central portion, with the angled frustum portion configured to activate upon experiencing a predetermined pressure differential. Pressure response systems may include a projection, a conductive arch, or a photo emitter configured to indicate a response to the predetermined pressure differential. Pressure response device may be a battery device, with the pressure response member configured to form part of an electrical conducting path until a predetermined pressure condition is reached.
US08525054B2 Discharge mechanism for circuit breaker
A circuit breaker and mechanism are provided for opening circuit breaker contact arms when the circuit breaker is moved between an installed and a withdrawn position in a drawout installation. The circuit breaker has a cross shaft coupled to a first linkage that rotates in response to the circuit breaker being moved. A second linkage translates in response to said first linkage rotating. A cam surface is operably coupled between the cross shaft and the first linkage. An opening latch shaft is coupled between the second linkage and a contact arm assembly such that the opening latch shaft moves the contact arm assembly from a closed position to an open position in response to the translation of the second linkage.
US08525053B2 Electrical switchgear
An electrical switchgear comprises a front, a back and a switch arrangement. The switch arrangement comprises a terminal arrangement comprising an electrical contact for a bus and an electrical contact for a load connection which are spaced apart along an axial direction; and a device that is driveable into said terminal arrangement to a service position to make an electrical connection between said electrical contact for said load connection and said electrical connection for said bus. The electrical contact for said load connection is located closer to said back of said switchgear than is said electrical contact for said bus.
US08525051B2 Sealing mechanism
The invention relates to a sealing mechanism for a scale, in which a connection element connected to a moving lifting element seals or opens an annular gap, wherein, for an opened annular gap, the connection element and lifting element form a biasing load for the weighing sensor of the scale.
US08525050B2 Method for testing multilayer tablets in a multiple rotary press, the tested tablets produced under normal operation, with m layers pressed and the m+1 layer suctioned off and the tablet fed to the testing station
The invention is related to a method for testing multilayer tablets in a multiple rotary press, in which die holes of a circulating die plate are successively filled with tablet material of different layers in consecutive filling devices, and the tablet material is compressed layer after layer to pressed articles having n layers by means of synchronously circulating compression punches in compression stations respectively associated to the filling devices, and the pressed articles are subsequently ejected and unloaded in a unloading station.
US08525046B2 Electronic apparatus
According to one embodiment, an electronic apparatus includes a housing having electric insulation properties, and a circuit element installed in the housing and including a plurality of connection terminals, wherein the housing includes an inner surface including a mounting region on which the circuit element is mounted, a plurality of adhesive filled portions in the mounting region, which are separated by a division wall in order to correspond to the connection terminals of the circuit element, and through which the connection terminals are inserted, and a plurality of traces provided on the inner surface of the housing, one ends of the traces running through the adhesive filled portions, wherein the adhesive filled portions of the housing are filled with conductive adhesive which fix the circuit element to the mounting region, and wherein the connection terminals are electrically connected to the traces by the conductive adhesive.
US08525044B2 System and method for protection against skimming of information from contactless cards
Contactless payment cards with on-card microchips are transported in mailers with RF shielding. The RF shielding is designed to prevent communication with and skimming of information from the contactless cards enclosed in the mailers while in transit.
US08525043B2 Printed substrate through which very strong currents can pass and corresponding production method
On a printed circuit or substrate board (10) designed to receive electronic components and having conductive tracks (12) printed on said board, one or more conductive bars (18) are provided that are mounted one after another between conductive link surfaces (140, 142, 144), the conductive bars (18) being electrically interconnected during a subsequent soldering process that is either a wave soldering process or a soldering process in a reflow oven.
US08525041B2 Multilayer wiring board and method for manufacturing the same
A wiring board has a substrate, a conductive pattern formed over the substrate, and an electronic component mounted to the substrate and having an electrode. The electrode of the electronic component is connected to the conductive pattern through a via hole. The thickness of the electrode of the electronic component is made less than the thickness of the conductive pattern.
US08525034B2 Cable guide and method of cable termination
A cable guide is used to constrain and locate wires or cables for preparation for and for connection to a circuit board or connector, for termination. The cable guide has openings that receive and secure wires during the termination process. A shaft of the cable guide may be used to secure, in a repeatable manner, a predetermined length of the wires with ends offset from a cable jacket, or other reference on or near the end of the cable. The cable guide and the cable/wires may be secured in a fixture that allows the wire ends to be repeatably scored to remove insulation.
US08525033B2 Stranded composite cable and method of making and using
Stranded composite cables include a single wire defining a center longitudinal axis, a first multiplicity of composite wires helically stranded around the single wire in a first lay direction at a first lay angle defined relative to the center longitudinal axis and having a first lay length, and a second multiplicity of composite wires helically stranded around the first multiplicity of composite wires in the first lay direction at a second lay angle defined relative to the center longitudinal axis and having a second lay length, the relative difference between the first lay angle and the second lay angle being no greater than about 4°. The stranded composite cables may be used as intermediate articles that are later incorporated into final articles, such as overhead electrical power transmission cables including a multiplicity of ductile wires stranded around the composite wires. Methods of making and using the stranded composite cables are also described.
US08525030B2 Communication wire
The present invention relates to an improved isolated core or insulated conductor with a low dielectric constant and reduced materials costs. Apparatuses and methods of manufacturing the improved isolated core or insulated conductor are also disclosed.
US08525028B2 Thermoplastic halogen-free flame retardant formulations
Highly-mineral-filled, halogen-free, flame-retardant compositions made from or containing a polypropylene thermoplastic elastomer, a polypropylene, a metal hydroxide filler, and a polar-monomer-grafted polyolefin elastomer compatibilizer. Such compositions can be employed in preparing various articles of manufacture, including extruded articles and coated conductors, such as cables.
US08525026B1 Epidermal friendly twist-on wire connectors
An epidermal friendly twist-on wire connector and a method of applying an epidermal twist-on wire connector having a resilient gripping region including a set of low profile, resilient ribs that are circumferentially spaced so that a users thumb and fingers can compressively and sequentially engage and compress at least a portion of a plurality of ribs as well as the valley between the ribs during application of a wire securement torque to the twist-on wire connector while at the same time inhibiting or preventing epidermal trauma in a users thumb and fingers.
US08525023B2 Cooled current leads for cooled equipment
A cooled current lead for conducting electrical current into a cooled vessel. The current lead comprises an electrical conductor (22) comprising a region (29) which, in use, is heated by electrical current flowing through it; a cooled component (31) situated above a the region (29) and which is provided with a path for removal of heat; and a thermo-siphon comprising a cavity (35) in thermal contact with both the region of the electrical conductor and the cooled component, said cavity containing a fluid (35).
US08525020B2 Photovoltaic cell with non-miscible electrolytes
A photovoltaic cell including at least: a closed chamber including two end walls arranged opposite one another, with at least one being intended to receive incident light radiation, and including at least one side wall formed by at least one stack of a first electrode and a second electrode electrically insulated from one another, the first electrode and second electrode each having an annular shape each being disposed at a periphery of a respective one of the two end walls; at least two non-miscible electrolytes placed in the closed chamber, forming two superimposed layers of which one is in contact with the first electrode and the other is in contact with the second electrode; and a photoactive layer, placed in the closed chamber, that achieves a photovoltaic conversion of energy of the incident light radiation.
US08525016B2 Thermoelectric devices including thermoelectric elements having off-set metal pads and related structures, methods, and systems
A thermoelectric device may include a thermoelectric element including a layer of a thermoelectric material and having opposing first and second surfaces. A first metal pad may be provided on the first surface of the thermoelectric element, and a second metal pad may be provided on the second surface of the thermoelectric element. In addition, the first and second metal pads may be off-set in a direction parallel with respect to the first and second surfaces of the thermoelectric element. Related methods are also discussed.
US08525012B1 System and method for selecting measure groupings for mixing song data
A system and method are provided for mixing song data based on measure groupings. A player or program may recognize measure groupings in a song through identifying cuepoints. The player or program may use the cuepoints and/or other identifiers of measure groupings to generate a transition between the song and other songs. Parts of one or both songs may be time-stretched, or frames may be added or deleted, such that the beats in both songs are substantially aligned during the transition. The system and method may also involve altering the sequence of frames in one or both of the songs, so that the transition may have various sonic qualities as desired by a user. A choice of transition modes may be provided via a user interface that allow the user some control over when and how transitions between songs are executed.
US08525009B2 Multi-function musical instrument pedal controller
A multi-function pedal controller may be used with a musical instrument, such as a keyboard percussion instrument, to allow control of both vibrato and damper functions. The multi-function pedal controller may control damper functions with a first range of motion and vibrato functions with a second range of motion, thereby facilitating intuitive control of both functions by the instrumentalist.
US08525006B2 Input device and recording medium with program recorded therein
An input device including: a first operation detecting section which is provided on one stick and detects acceleration based on movement of the one stick; a second operation detecting section which is provided on an other stick and detects acceleration based on movement of the other stick; a first strike judging section which judges whether or not the one stick and the other stick have struck against one another, based on the acceleration detected by the first operation detecting section and the acceleration detected by the second operation detecting section; and an instructing section which instructs to produce a sound corresponding to striking of the one stick and the other stick against one another, when the first strike judging section judges that the one stick and the other stick have struck against one another.
US08525005B1 Inbred sunflower (Helianthus annuus) line, designated ON7321R
The present invention relates to an inbred sunflower line, designated ON7321R. The invention relates to the seeds of inbred sunflower line ON7321R, to the plants of inbred sunflower line ON7321R and to the methods for producing a sunflower plant, either inbred or hybrid, by crossing the inbred line ON7321R with itself or another sunflower line. The invention further relates to methods for producing a sunflower plant containing in its genetic material one or more transgenes and to the transgenic plants produced by that method and to methods for producing other inbred sunflower lines derived from the inbred ON7321R.
US08525003B2 Plants and seeds of corn variety CV126318
According to the invention, there is provided seed and plants of the corn variety designated CV126318. The invention thus relates to the plants, seeds and tissue cultures of the variety CV126318, and to methods for producing a corn plant produced by crossing a corn plant of variety CV126318 with itself or with another corn plant, such as a plant of another variety. The invention further relates to corn seeds and plants produced by crossing plants of variety CV126318 with plants of another variety, such as another inbred line. The invention further relates to the inbred and hybrid genetic complements of plants of variety CV126318.
US08525002B2 Inbred corn line ML9
An inbred corn line, designated ML9, is disclosed. The invention relates to the seeds of inbred corn line ML9, to the plants and plant parts of inbred corn line ML9 and to methods for producing a corn plant, either inbred or hybrid, by crossing inbred corn line ML9 with itself or another corn line. The invention further relates to methods for producing a corn plant containing in its genetic material one or more transgenes and to the transgenic plants produced by that method and to methods for producing other inbred corn lines derived from inbred corn line ML9.
US08524998B1 Maize variety inbred PH18NM
A novel maize variety designated PH18NM and seed, plants and plant parts thereof. Methods for producing a maize plant that comprise crossing maize variety PH18NM with another maize plant. Methods for producing a maize plant containing in its genetic material one or more traits introgressed into PH18NM through backcross conversion and/or transformation, and to the maize seed, plant and plant part produced thereby. Hybrid maize seed, plant or plant part produced by crossing the variety PH18NM or a locus conversion of PH18NM with another maize variety.
US08524996B1 Inbred maize variety PH18N5
A novel maize variety designated PH18N5 and seed, plants and plant parts thereof. Methods for producing a maize plant that comprise crossing maize variety PH18N5 with another maize plant. Methods for producing a maize plant containing in its genetic material one or more traits introgressed into PH18N5 through backcross conversion and/or transformation, and to the maize seed, plant and plant part produced thereby. Hybrid maize seed, plant or plant part produced by crossing the variety PH18N5 or a locus conversion of PH18N5 with another maize variety.
US08524994B1 Inbred corn line NPAF4543
Basically, this invention provides for an inbred corn line designated NPAF4543, methods for producing a corn plant by crossing plants of the inbred line NPAF4543 with plants of another corn plant. The invention relates to the various parts of inbred NPAF4543 including culturable cells. This invention also relates to methods for introducing transgenic transgenes into inbred corn line NPAF4543 and plants produced by said methods.
US08524987B1 Soybean variety XB34AV11
A novel soybean variety, designated XB34AV11 is provided. Also provided are the seeds of soybean variety XB34AV11, cells from soybean variety XB34AV11, plants of soybean XB34AV11, and plant parts of soybean variety XB34AV11. Methods provided include producing a soybean plant by crossing soybean variety XB34AV11 with another soybean plant, methods for introgressing a transgenic trait, a mutant trait, and/or a native trait into soybean variety XB34AV11, methods for producing other soybean varieties or plant parts derived from soybean variety XB34AV11, and methods of characterizing soybean variety XB34AV11. Soybean seed, cells, plants, germplasm, breeding lines, varieties, and plant parts produced by these methods and/or derived from soybean variety XB34AV11 are further provided.
US08524985B1 Soybean variety XB47P11
A novel soybean variety, designated XB47P11 is provided. Also provided are the seeds of soybean variety XB47P11, cells from soybean variety XB47P11, plants of soybean XB47P11, and plant parts of soybean variety XB47P11. Methods provided include producing a soybean plant by crossing soybean variety XB47P11 with another soybean plant, methods for introgressing a transgenic trait, a mutant trait, and/or a native trait into soybean variety XB47P11, methods for producing other soybean varieties or plant parts derived from soybean variety XB47P11, and methods of characterizing soybean variety XB47P11. Soybean seed, cells, plants, germplasm, breeding lines, varieties, and plant parts produced by these methods and/or derived from soybean variety XB47P11 are further provided.
US08524984B1 Soybean variety XB42R11
A novel soybean variety, designated XB42R11 is provided. Also provided are the seeds of soybean variety XB42R11, cells from soybean variety XB42R11, plants of soybean XB42R11, and plant parts of soybean variety XB42R11. Methods provided include producing a soybean plant by crossing soybean variety XB42R11 with another soybean plant, methods for introgressing a transgenic trait, a mutant trait, and/or a native trait into soybean variety XB42R11, methods for producing other soybean varieties or plant parts derived from soybean variety XB42R11, and methods of characterizing soybean variety XB42R11. Soybean seed, cells, plants, germplasm, breeding lines, varieties, and plant parts produced by these methods and/or derived from soybean variety XB42R11 are further provided.
US08524977B2 Plants and seeds of hybrid corn variety CH310852
According to the invention, there is provided seed and plants of the hybrid corn variety designated CH310852. The invention thus relates to the plants, seeds and tissue cultures of the variety CH310852, and to methods for producing a corn plant produced by crossing a corn plant of variety CH310852 with itself or with another corn plant, such as a plant of another variety. The invention further relates to genetic complements of plants of variety CH310852.
US08524971B2 Catalyst for higher production rates in hydrocarbon dehydrogenation
A process is presented for the dehydrogenation of hydrocarbons in a radial flow reactor. The process includes the continuous feeding of catalyst into the reactor and the continuous withdrawal of catalyst from the reactor, where the catalyst is modified to increase the increased density. The catalyst is a layered structure with a dense core and an active catalytic outer layer.
US08524968B2 Process to make base oil by oligomerizing low boiling olefins
A process for making base oil, comprising: oligomerizing one or more olefins having a boiling point less than 82° C. in the presence of an ionic liquid catalyst to produce the base oil having a kinematic viscosity at 40° C. of 1100 mm2/s or higher. Also, a process, comprising: oligomerizing the olefins in the presence of an ionic liquid catalyst to produce the base oil having a kinematic viscosity at 40° C. of 300 mm2/s or higher and a low cloud point, wherein a wt % yield of products boiling at 482° C.+ (900° F.+) is at least 65 wt % of a total yield of products from the oligomerizing. Additionally, a process, comprising: oligomerizing the olefins in the presence of an ionic liquid catalyst to produce the base oil having a kinematic viscosity at 40° C. greater than 1100 mm2/s and a low cloud point.
US08524967B2 Monoalkylated aromatic compound production
A process for producing a monoalkylated aromatic compound in an alkylation reaction zone, said process comprising the steps of: (a) providing a first catalytic particulate material which comprises MCM-56 and having a ratio of surface area over volume ratio greater than about 79 cm−1, (b) providing said alkylation reaction zone with an alkylatable aromatic compound, an alkylating agent, and said first catalytic particulate material; and (c) contacting said alkylatable aromatic compound and said alkylating agent with said catalytic particulate material in said alkylation reaction zone maintained under alkylation conditions, to form a product comprised of said monoalkylated aromatic compound and polyalkylated aromatic compound(s).
US08524965B2 Method of making an alkylated aromatic using acidic ionic liquid catalyst
A process for alkylating an aromatic compound comprising reacting at least one aromatic compound with a mixture of olefins selected from olefins having from about 8 to about 100 carbon atoms, in the presence of an acidic ionic liquid catalyst, wherein the resulting product comprises at least about 50 weight percent of a 1, 2, 4 tri-substituted aromatic compound or a 1, 2, 3 tri-substituted aromatic compound or mixtures thereof.
US08524963B2 Supported organoiridium catalysts for alkane dehydrogenation
Solid supported organoiridium catalysts, a process for preparing such solid supported organoiridium catalysts, and the use of such solid supported organoiridium catalysts in dehydrogenation reactions of alkanes is provided. The catalysts can be easily recovered and recycled.
US08524961B2 Integrated catalytic cracking and reforming processes to improve p-xylene production
A process for maximizing p-xylene production includes producing a naphtha fraction and a light cycle oil fraction from a fluid catalytic cracking zone. These fractions are combined and hydrotreated. Fractionation of the hydrotreated product makes a hydrocracker feed that is sent to a hydrocracking zone to make a naphtha cut and a hydrocracker product. The hydrocracker product is recycled back to the fractionation zone, and the naphtha cut is dehydrogenated in a dehydrogenation zone to make aromatics. Reforming catalyst from a catalyst regenerator moves downward through the dehydrogenation zone. Straight run naphtha and raffinate from the aromatics unit are introduced to an additional series of reforming zones. The reforming catalyst moves in parallel through the first reforming zone and the dehydrogenation zones, then is combined for entry to the second and subsequent reforming zones prior to regeneration.
US08524950B2 Preparation of chiral amides and amines
This invention provides a convenient method for converting oximes into enamides. The process does not require the use of metallic reagents. Accordingly, it produces the desired compounds without the concomitant production of a large volume of metallic waste. The enamides are useful precursors to amides and amines. The invention provides a process to convert a prochiral enamide into the corresponding chiral amide. In an exemplary process, a chiral amino center is introduced during hydrogenation through the use of a chiral hydrogenation catalyst. In selected embodiments, the invention provides methods of preparing amides and amines that include the 1,2,3,4-tetrahydro-N-alkyl-1-naphthalenamine or 1,2,3,4-tetrahydro-1-naphthalenamine substructure.
US08524947B2 Acylsulfonamides and processes for producing the same
The present disclosure relates to acylsulfonamides and processes for their preparation. The processes involve a target-guided synthesis approach, whereby a thioacid and a sulfonyl azide are reacted in the presence of a biological target protein, a Bcl-2 family protein, to form the acylsulfonamide.
US08524946B2 Fluoroboron compound, aminomethylating agent for aromatic ring made of the same, and production method of compound containing aminomethyl aromatic ring using aminomethylating agent
A production method of a compound containing a primary, secondary, or tertiary aminomethyl aromatic ring of the present invention includes: using a fluoroboron compound or a dimer thereof, or solvates thereof, which are represented by a formula (I): Ra(Rb)N—CH2—BF3M  (I) as an aminomethylating agent for an aromatic ring; and reacting the aminomethylating agent with an aromatic ring-containing compound, which can react with the aminomethylating agent, under the presence of a metal catalyst such as a palladium compound so as to perform the direct aminomethylation of the aromatic ring.
US08524945B2 Method for producing acrolein comprising the regeneration of a raw glycerin phase
The invention relates to a method for producing acrolein by dehydrating an aqueous glycerin phase in an acrolein reaction region, obtaining an aqueous acrolein reaction phase; at least partially separating the aqueous acrolein reaction phase into an acrolein-rich acrolein phase and an acrolein-poor residual phase comprising glycerin, water and various other residuals; and recirculating at least part of the residual phase into the acrolein reaction region. Additionally, removing at least one of the residuals, other than glycerin or water, from either of the glycerin phase or a mixture phase obtained by mixing the glycerol phase with the low-acrolein residue phase and feeding the resulting purified glycerin or mixture phase into the acrolein reaction region. The invention furthermore relates to a method for producing acrylic acid, water-absorbing polymer formations, compounds and hygiene articles, and to devices for carrying out those methods.
US08524943B2 Production of trans-4-aminocyclopent-2-ene-1-carboxylic acid derivatives
Methods of producing compositions of trans-4-amino-2-cyclopentene-1-carboxylic acid derivatives are described. Also described is an amine salt of a compound having formula A, having components present in both cis and trans structures.
US08524940B2 Nitro group-containing ether compound and method for producing same
It is possible to produce oseltamivir safely and stably in large quantities by using as a starting material tartaric acid, mannitol or arabinose, via dihydroxyhexenoic acid ester of the formula (4c): (wherein R1, R2 and R6 are same or different and are each alkyl, aryl, substituted aryl, aralkyl, substituted aralkyl or aromatic heterocyclic group, and R1 and R2 are not methyl simultaneously).
US08524939B2 Intermediates for the synthesis of benzindene prostaglandins and preparations thereof
Novel processes for preparing optically active cyclopentanones 1 which are useful for the preparation of benzindene Prostaglandins and novel cyclopentanones are provided. The invention also provides novel processes of preparing benzindene Prostaglandins and novel intermediates for benzindene Prostaglandins.
US08524937B2 Process for preparing polyol esters
The present invention relates to a process for preparing polyol esters by reacting polyols with linear or branched aliphatic monocarboxylic acids having 3 to 20 carbon atoms by partial recycling of the aliphatic monocarboxylic acid removed into the esterification reaction or into subsequent esterification batches.
US08524936B2 Manufacturing process for sitagliptin from L-aspartic acid
The present invention relates to a novel manufacturing process of pharmaceutically active compound of formula I used as oral anti-diabetic drug. Starting from L-aspartic acid derivate of formula IV the invention describes preparation of the chiral (R)-β-amino acid of formula II known as a precursor in the synthesis of Sitagliptin (formula I).
US08524933B2 Beta-ketoester group-containing organopolysiloxane compound
A novel organosilicon compound is provided as an organosilicon compound containing a β-ketoester structure that has minimal volatile components and generates a minimal amount of alcohol when used as a component within all manner of treatment agents. The organopolysiloxane is represented by an average composition formula shown below: YaR1bR2cSi(OR3)d(OH)eO(4-a-b-c-d-e)/2  (1) (wherein Y represents an organic group containing a β-ketoester group that may be at least partially enolized, R1 represents a monovalent hydrocarbon group that may optionally include a functional group such as a mercapto group, an epoxy group or a (meth)acryloyloxy group, R2 represents a monovalent hydrocarbon group that contains no functional groups, R3 represents a monovalent hydrocarbon group, and a, b, c, d and e are numbers that satisfy 0.01≦a≦1, 0≦b<1, 0≦c≦2, 0≦d≦2, and 0≦e≦1 respectively, provided that 2≦a+b+c+d+e≦3).
US08524924B2 Process for furfural production from biomass
Furfural is produced from a lignocellulosic feedstock comprising glucan and xylan. The feedstock is contacted with water in the presence of an acid catalyst. The resulting mixture is contacted with at least one water-immiscible organic solvent to form a mixture comprising an aqueous phase and an organic phase. Under suitable reaction conditions, furfural is produced and preferentially partitions into the organic phase, from which it may be recovered.
US08524923B2 Processes for preparing diacids, dialdehydes and polymers
Alcohols are catalytically oxidized to aldehydes, in particular to benzaldehyde and diformylfuran, which are useful as intermediates for a multiplicity of purposes. The invention also relates to the polymerization of the dialdehyde and to the decarbonylation of the dialdehyde to furan.
US08524922B2 Process and plant for recovering solid reaction products from solutions
A process for recovering solid reaction products during partial oxidation of hydrocarbons in a liquid solvent as a reaction medium by multi-stage evaporative crystallization includes determining a final temperature of the multi-stage evaporative crystallization based on a melting point of the solvent. The pressure and temperature of the solvent is reduced in steps via successive crystallization stages until the final temperature is reached. Each of the crystallization stages includes a compressor configured to perform the reducing of the pressure and to withdraw vapors formed. The vapors from the compressor of a lower expansion pressure crystallization stage are introduced into a vapor discharge conduit of a next successive higher expansion pressure crystallization stage upstream of the compressor of the higher expansion pressure crystallization stage.
US08524921B2 Liquid tetracarboxylic dianhydrides and process for the preparation thereof
The invention relates to a tetracarboxylic dianhydride represented by the following formula (1). [In formula (1) R1, R2, R3 and R4 each independently represent an alkyl group having from 1 to 5 carbon atoms, m represents a number from 1 to 30, all of the silicon atoms bonding to the norbornane rings are in an exo-configuration with respect to the norbornane rings, and all of the dicarboxylic anhydride groups bonding to the norbornane rings are in an exo-configuration with respect to the norbornane rings.]
US08524920B2 Active polymeric filters
A compound includes a polymer where the polymer includes a pendant dioxirane moiety. Cost-effective, facilitated generation of a polymer including a pendant dioxirane moiety allows for the compound to be disposable or be easily recycled. The compound can be used in air purification and liquid purification to not only remove particulate matter, but also to destroy microorganisms and remove volatile organic compounds.
US08524919B2 Active polymeric filters
A compound includes a polymer where the polymer includes a pendant dioxirane moiety. Cost-effective, facilitated generation of a polymer including a pendant dioxirane moiety allows for the compound to be disposable or be easily recycled. The compound can be used in air purification and liquid purification to not only remove particulate matter, but also to destroy microorganisms and remove volatile organic compounds.
US08524917B2 6-substituted indole-3-carboxylic acid amide compounds having sphingosine-1-phosphate (S1P) receptor antagonist biological activity
The invention provides compounds represented by the formula I, each of which compounds may have sphingosine-1-phosphate receptor agonist and or antagonist biological activity: and wherein the variables Y, R4, n, o, A, A1, A2, X, Z, R1, R3, R2, p, q and r are as defined in the specification. These compounds are useful for treating a disease or condition selected from the group consisting of glaucoma, dry eye, angiogenesis, cardiovascular conditions and diseases, and wound healing.
US08524912B2 Process for the preparation of [1-hydroxy-2-(1H-imidazol-1-yl)- ethylidene]bisphosphonic acid
A process for the preparation of [1-hydroxy-2-(1H-imidazol-1-yl)-ethylidene]bisphosphonic acid consists of the reaction of aqueous solution of 1H-imidazole-1-acetic acid hydrochloride with phosphorus trichloride followed by removal of the excess of phosphorus trichloride, addition of water and hydrolysis of the reaction products. In order to isolate the product the post-reaction mixture is filtered and the anti-solvent is added to the aqueous filtrate in order to crystallize out [1-hydroxy-2-(1H-imidazol-1-yl)-ethylidene]bisphosphonic acid monohydrate.
US08524909B2 Tetrahydro-pyran derivatives
The present invention relates to a compound of formula I wherein R1/R2 are independently from each other hydrogen, (CR2)o-cycloalkyl, optionally substituted by lower alkyl or hydroxy, or are lower alkyl or heterocycloalkyl, and o is 0 or 1; and R may be the same or different and is hydrogen or lower alkyl; or R1 and R2 may form together with the N atom to which they are attached a heterocycloalkyl group, selected from the group consisting of pyrrolidinyl, piperidinyl, 3-aza-bicyclo[3.1.0]hex-3-yl or 2-aza-bicyclo[3.1.0]hex-2-yl, which are optionally substituted by hydroxy; R3 is S-lower alkyl, lower alkyl, lower alkoxy or cycloalkyl; R3′ is hydrogen, lower alkyl substituted by halogen, lower alkyl or lower alkoxy R4 is lower alkyl substituted by halogen, lower alkyl or lower alkoxy; X is —O— or —CH2—; X′ is —O— or —CH2—; with the proviso that one of X or X′ is always —O— and the other is —CH2—; or to a pharmaceutically acceptable acid addition salt, to a racemic mixture, or to its corresponding enantiomer and/or optical isomer thereof. It has been found that the compounds of formula I are good inhibitors of the glycine transporter 1 (GlyT-1) and therefore they may be used for the treatment of schizophrenia.
US08524904B2 Process for the preparation of 6-alpha-hydroxy-N-alkylated opiates
The present invention is directed to the preparation of 6-hydroxy morphinans having formula (II) or N-alkylated 6-hydroxy morphinans having formula (III).
US08524902B2 [1,2,4]triazolo[4,3-f]pteridines useful as inhibitors of protein kinases
The present invention relates to compounds useful as inhibitors of protein kinase, represented by Structural Formula (I): wherein the variables in Structural Formula (I) are as described herein. The invention also provides pharmaceutically acceptable compositions comprising said compounds and methods of using the compositions in the treatment of various disease, conditions, or disorders. The invention also provides processes for preparing compounds of the inventions.
US08524901B2 Compositions and methods for inhibition of the JAK pathway
Disclosed are compounds of formula I, compositions containing them, and methods of use for the compounds and compositions in the treatment of conditions in which modulation of the JAK pathway or inhibition of JAK kinases, particularly JAK 2 and JAK3, are therapeutically useful.
US08524897B2 Crystalline oxazine derivative
The invention relates to 5-cyano-3-methyl-pyridine-2-carboxylic acid [3-((3R,6R)-5-amino-3,6-dimethyl-6-trifluoromethyl-3,6-dihydro-2H-[1,4]oxazin-3-yl)-4-fluoro-phenyl]-amide in crystalline form, to its preparation, its medical use and to medicaments comprising said compound in crystalline form.
US08524895B2 Method for preparing amide
The present invention provides a method for preparing amides, in which an amino acid ionic liquid is used as both a reaction medium and a catalyst to catalyze Beckman rearrangement of a ketoxime, so as to produce an amide. In the method, the rearrangement is conducted by catalyzing a ketoxime with an amino acid ionic liquid having the asymmetric property at a moderate reaction temperature during a short reaction time, so as to produce an amide without adding other catalysts such as concentrate sulfuric acid. The method has advantages such as avoiding corrosion in equipments with pipelines, the high conversion rate of ketoximes and the high selectivity of amides.
US08524891B2 Tetraazaporphyrin-based compounds and their uses
Asymmetrically substituted metal-phthalocyanine compounds are disclosed. These compounds and other phthalocyanine-derivatives are used in bioimaging, bioanalysis, FRET and quenching techniques, photodynamic therapy, DNA analysis for cells, proteins, tissues and other biological entities, and other applications. Near-infrared fluorescence minimizes matrix effects typically seen in other methods of analyzing biochemical entities in cells, proteins, tissues and other biological entities.
US08524889B2 Highly-branched starch, its production and uses
An object of the present invention is to provide a novel starchy substance having a retrogradation-resistance, a process for producing the starchy substance efficiently from a material starch by enzymatic reaction, and uses thereof. The present invention attains the above object by providing branched starch having 6-α-maltosyl- and/or 6-α-maltotetraosyl-structure(s) with a marked retrogradation-resistance, a process for producing the branched starch without lowering the molecular weight of material starch, and uses thereof.
US08524888B2 Method of producing D-psicose crystals
The present invention relates to a method of producing D-psicose crystals from a D-psicose solution by using supersaturation.
US08524887B2 Regioselectively substituted cellulose esters produced in a tetraalkylammonium alkylphosphate ionic liquid process and products produced therefrom
This invention relates a cellulose solution comprising cellulose and at least one tetraalkylammonium alkylphosphate and processes to produce the cellulose solution. Another aspect of this invention relates to shaped articles prepared from a cellulose solution comprising cellulose and at least one tetraalkylammonium alkylphosphate. Another embodiment of this invention relates to compositions comprising derivatives of cellulose prepared from a cellulose solution comprising at least one tetraalkylammonium alkylphosphate. Another embodiment of this invention relates to compositions comprising regioselectively substituted cellulose esters prepared from a cellulose solution comprising cellulose and at least one tetraalkylammonium alkylphosphate. In another embodiment of the invention, the cellulose esters of the present invention are used as protective and compensation films for liquid crystalline displays.
US08524885B2 Hydrazido derivatives of hyaluronic acid
Disclosed are chemically modified hyaluronic acid (HA) derivatives containing hydrazido groups directly linked to the glucuronic acid residues of HA. Said hydrazido groups are used to obtain crosslinked and labeled HA derivatives. The invention further relates to methods of preparation of said HA derivatives.
US08524879B2 RNA interference suppresion of neurodegenerative diseases and methods of use thereof
The present invention is directed to small interfering RNA molecules (siRNA) targeted against nucleic acid sequence that encodes huntingtin or ataxin-1, and methods of using these siRNA molecules.
US08524876B2 RNAi molecule targeting thymidylate synthase and application thereof
This invention provides a novel RNAi molecule that can significantly potentiate antitumor effects of a 5-FU antitumor agent. The RNAi molecule comprises the nucleotide sequence shown in SEQ ID NO: 2. The invention also provides an antitumor agent comprising such RNAi molecule and a 5-FU antitumor agent.
US08524875B2 Nucleic acids encoding SOX10 promoter and methods to isolate SOX10 expressing cells
DNA enhancer sequences are provided for use in constructs to identify early stage embryonic cells. The enhancer sequences can be used in parallel with short-hairpin RNA in a vector construct for endogenously regulated gene knockdowns. The disclosed enhancer sequences can be used to isolate a selected population of early stage embryonic cells.
US08524873B2 Sugar donor
The present invention provides a compound represented by the following formula (1): wherein X1 and X2 each independently represent a hydrogen atom or a hydroxyl-protecting group; Y represents a C7-20 aralkyl group which may optionally have one or more substituents selected from a halogen atom, a lower alkyl group or a lower alkoxy group; and Z represents a halogen atom, a C1-4 alkylthio, or an arylthio group, or its corresponding sulfoxide group.
US08524870B2 Anti-platelet membrane glycoprotein VI monoclonal antibody
The present invention provides an antibody which has the following features, its active fragment, or a derivative thereof: a) It specifically binds to human platelet membrane glycoprotein VI (GPVI); b) The function to activate a platelet and/or the function to induce a thrombocytopenia in vivo are low; and c) It at least partially depletes GPVI on the platelet membrane by contacting with a platelet.
US08524868B2 Polypeptide fragments of the hepatitis E virus, the vaccine composition comprising said fragments and the diagnostic kits
The present invention relates to polypeptide(s) comprising the amino acid sequence as set forth in SEQ ID No. 1 of hepatitis E virus ORF 2 or its fragment, which is in the form of n-polymeric polypeptide, wherein n is an integer from 1-180; to a chimeric protein consisting of a polypeptide of the present invention and a conserved fragment of hemagglutin antigen from influenza virus; to a polypeptide of the present invention bound to a polypeptide containing epitope from hepatitis E virus ORF3 or an immunogenic fragment thereof; to a recombinant expression vector comprising the DNA molecule encoding the above polypeptides and the host cell transformed with said recombinant expression vector which is able to express polypeptide of the present invention. The present invention further relates to a vaccine composition against hepatitis E virus which comprises the above-mentioned polypeptide, or diagnostic kit for hepatitis E virus infection comprising the above-mentioned polypeptide, which includes IgG, IgM, or total antibody diagnostic kit for hepatitis E virus, and to the use of vaccine composition and diagnostic kit for prophylaxis, diagnosis and/or treatment of hepatitis E virus infection.
US08524867B2 Optimized antibodies that target CD19
Antibodies that target CD19, wherein the antibodies comprise at least one modification relative to a parent antibody, wherein the modification alters affinity to an FcyR or alters effector function as compared to the parent antibody, and methods of using the antibodies.
US08524866B2 Antibodies to the alpha-7 nicotinic receptors and methods of treating inflammatory disorders with the same
An antibody or an antigen binding fragment thereof which binds to mammalian α7 subunit of a nicotinic acetylcholine receptor or its functional variant and which is an agonist of said receptor or variant. Pharmaceutical compositions comprising same. A method of treating a subject suffering from an inflammatory condition comprising administering to said subject an antibody or an antigen-binding fragment as described herein.
US08524863B2 Amyloid-beta peptide crystal structure
The invention relates provides a novel crystal structure of the fibrillogenic part of amyloid β-peptide (Aβ). More specifically the crystal structure is Aβ-IgNAR and, accordingly the present invention also relates to selecting and/or designing compounds that modulate amyloid β-peptide (Aβ) activity using techniques such as in silico screening and crystal soaking experiments. The invention further relates to compounds and methods for inhibiting interaction between amyloid β-peptide (Aβ) monomers, more particularly, inhibiting or disrupting amyloid β-peptide (Aβ) oligomer formation and toxic activity.
US08524861B2 Treatment of bacterial infections
The invention relates to polypeptides, comprising repeats of peptides derived from apolipoproteins, which exhibit antibacterial activity and to nucleic acids encoding the same. The invention further provides the use of such polypeptides, derivatives, analogues or nucleic acids as medicaments, and also their use in methods of preventing or treating bacterial infection or objects and surfaces. The invention further extends to objects, such as contact lenses, coated with the polypeptides.
US08524856B2 PHA compositions comprising PBS and PBSA and methods for their production
Compositions of PHAs with PBS and PBSA are described and methods of making the same.
US08524854B2 Chloro-substituted polyetherimides having improved relative thermal index
A polyetherimide having an OH content that is greater than 0 and equal or less than 100 ppm; a Relative Thermal Index that is greater than or equal to 170° C.; and a chlorine content that is greater than 0 ppm is disclosed herein. A method for preparing the polyetherimide is also disclosed.
US08524852B2 Thermoset polyurethanes based on moisture-resistance polyols for use in golf balls
Golf balls containing at least one layer made from a thermoset polyurethane or polyurethane-urea that is the reaction product of a polyisocyanate with moisture-resistant polyol and a curing agent are provided. The moisture-resistant polyol may be prepared by dimerizing unsaturated aliphatic monocarboxylic acid or ester containing 10 to 60 carbon atoms followed by reacting it with a monomeric, oligomeric, or polymeric diol. In one preferred version, the moisture-resistant polyol is a branched polyester polyol containing 36 carbon atoms. The composition can be prepared using prepolymer or one-shot manufacturing techniques. The thermoset composition has good cross-link density. The resulting golf ball has desirable playing performance properties including high resiliency, toughness, impact durability, moisture-resistance, and soft feel.
US08524851B2 Silicon-based hardmask composition and process of producing semiconductor integrated circuit device using the same
A silicon-based hardmask composition, including an organosilane polymer represented by Formula 1: {(SiO1.5—Y—SiO1.5)x(R3SiO1.5)y(XSiO1.5)z}(OH)e(OR6)f  (1).
US08524847B2 Organic insulating material, varnish for resin film using the same, resin film and semiconductor device
An organic insulating material includes a prepolymer of a cage structure compound having a polymerizable unsaturated bond-containing group and a cage structure with an adamantane structure as the minimal unit. The prepolymer has a number-average molecular weight of between 2,000 and 500,000 based on polystyrene and measured by gel permeation chromatography. The prepolymer includes unsaturated bonds produced by reaction between the polymerizable unsaturated bonds and the unreacted polymerizable unsaturated bonds. The prepolymer has a residue rate of unreacted polymerizable unsaturated bonds of between 20% and 80%.
US08524846B1 Trianionic ligand precursor compounds and uses thereof in constrained geometry catalysts
Trianionic ligand precursor compounds, catalyst systems containing the precursor compounds, and uses of the precursor compounds are described. The present invention also provides constrained geometry catalysts, methods to make the constrained geometry catalysts and methods to use the constrained geometry catalysts in various reaction systems, including polymerization, metathesis reactions, and hydroamination reactions.
US08524827B2 Method for the stabilization of polyvinylpyrrolidones
Method for stabilizing polyvinylpyrrolidones, which comprises treating the polyvinylpyrrolidones with sulfur dioxide, sulfurous acid or alkali metal sulfites and then with free-radical scavenger, and converting the solutions treated in this way into the powdered polyvinylpyrrolidones by drying.
US08524825B2 Peel-coat compositions
A composition for forming a peelable coating, the composition comprising an aqueous carrier, a water-dispersible polyvinyl butyral, and an acrylic latex compound.
US08524823B2 Rubber compositions comprising organosilicon coupling agents and inorganic fillers
Elastomeric isoprene rubber compositions contain an effective amount of a coupling agent (A) comprising an organosilicon compound with coupling agent functions for inorganic/elastomeric fillers and include (B) at least one natural or synthetic rubber elastomer, (C) an inorganic filler as reinforcement filler, (D) other conventional constituents or additives comprising vulcanization agents; the coupling agent (A) being a functionalized organosilicon compound, including the following two compounds (i) and (2i), (i) being at least one functionalized siloxane corresponding to the formula (I): [(G0)3SiO1/2]m [(G0)2SiO2/2]n [G0SiO3/2]o [SiO4/2]p [(G2)a(G1)a′(Z—CO—N═N—CO-A)SiO(3-a-a′)/2]q and (2i) being a mixture of at least one functionalized siloxane (i) with (3i) at least one functionalized organosilane also corresponding to formula (I) where m=n=o=p=0 (zero), q=1, a=0, 1, 2 or 3 and the sum a+a′=3.
US08524820B2 Golf balls containing ionomers and polyamines or tertiary polyamides
Provided herein are compositions comprising an ionomer and a polyamine or a tertiary polyamide. The polyamine and the tertiary polyamide have a molecular weight of greater than 500 Da and do not contain an ester moiety or a primary amine moiety. The polyamine comprises at least three moieties that are tertiary amines or hindered secondary amines, and the polyamide comprises tertiary amide moieties and no secondary or primary amide moieties. The compositions may optionally include a filler. Further provided are articles such as golf balls and films containing these compositions.
US08524815B2 Non halogen flame retardant thermoplastic polyurethane
Flame retardant thermoplastic polyurethane (TPU) compositions are disclosed having a flame retardant package comprising an organo-phosphinate component, an organo-phosphate component, and a polyhydric alcohol. The flame retardant components may be present in an amount from about 5 to about 40 weight percent of the phosphinate compound; from about 5 to about 20 weight percent of the phosphate compound, and from about 0.1 to about 15 weight percent of the polyhydric alcohol, based on the total weight of the TPU composition. Processes are disclosed to make the TPU compositions and to make wire and cable constructions employing the TPU compositions as the jacket of the wire and cable constructions. The TPU compositions exhibit excellent flame retardant capabilities as measured by Limited Oxygen Index testing and/or UL 94 Vertical Burn tests.
US08524814B2 Phosphonate bonding compositions
The present invention provides for compounds comprising at least one phosphonate or phosphinate moiety; and at least one moiety selected from an aromatic nitroso or an aromatic nitroso precursor and combinations thereof. Adhesive compositions comprising the compounds may find utility in bonding polymers to metal and or hydroxylated surfaces such as glass. Suitable polymers include natural and synthetic rubbers. The aromatic nitroso precursor may be a nitrosobenzene precursor such as at least one of a quinone dioxime or a quinone oxime.
US08524813B2 Flame-retarded compositions of styrene-containing polymers
A flame-retarded styrene-containing polymer composition, which comprises a styrene-containing polymer, tris(2,4,6-tribromophenoxy)-s-triazine, 0.5-1.7 wt % antimony trioxide, and an anti-dripping agent. The bromine content of the composition is generally in the range between 8 and 18 wt %. Additional brominated flame retarding agents may also be included in the composition.
US08524809B2 Low odor compositions and methods to attain low odor compositions
This invention provides stable aqueous compositions including stable coating compositions, and methods of their production. The stable aqueous compositions and stable aqueous coating compositions comprise i) an aqueous dispersion of one or more emulsion-polymerized addition polymer comprising polymerized units of one or more carboxylester monomer, wherein at least one carboxylester monomer is a vinyl ester monomer; ii) one or more carboxylesterase enzyme; iii) one or more mono-alcohol with a formula molecular weight of less than 76; iv) optionally, acetaldehyde; and v) optionally, one or more organic carboxylester with a normal boiling point of less than 150° C.; and wherein the aqueous composition has a headspace volatile organic compound (VOC) content, as measured by headspace gas chromatography-mass spectrometry (GC-MS) at 33° C., characterized by a content of less than 10 ppm of acetaldehyde, and less than 10 ppm of the one or more organic carboxylester, and more than 50 ppm of the one or more mono-alcohol. Preferably, the ester hydrolysis activity in the composition is less than 0.010 micromole/minute.
US08524805B2 Particle comprising a matrix and a radical initiator
The invention pertains to a particle comprising a composition containing a matrix and a peroxide or azo radical initiator, wherein the particle is a fiber or fibrid selected from aramid, polyester, polyamide, cellulose, and glass. The invention further relates to particle-elastomers comprising said composition, and skim products, tires, tire treads, and belts comprising these particle-elastomers.
US08524804B2 Surface-treated fiber, resin composition, and molded article of the composition
A resin composition includes a fiber and a polyolefin resin and can provide a molded article having excellent mechanical strength such as flexural strength and impact resistance. The resin composition includes (i) a surface-treated fiber (A) which comprises 100 parts by weight of a fiber (A-I) comprising a polyalkylene terephthalate and/or a polyalkylene naphthalene dicarboxylate and 0.1 to 10 parts by weight of a sizing agent (A-II) adhered to the surface of the fiber (A-I), and (ii) a polyolefin resin modified with an unsaturated carboxylic acid and/or an unsaturated carboxylic acid derivative (a modified polyolefin resin (B)) as a resin component.
US08524799B2 Biofilm growth prevention
A biostatic coating comprising a coating composition which on drying produces an intrinsically hydrophobic film. The coating composition includes a biocidal complex A-B in which A is a phenolic biocide and B is selected from polyvinylpyrrolidone (“PVP”), PVP polymers, PVP copolymers and mixtures thereof. The coating composition for example is selected from acrylic and methacrylic polymer based compositions, acrylic and methacrylic copolymer based compositions, vinyl polymer based compositions, vinyl copolymer based compositions, epoxy resins, epoxy esters, and mixtures thereof. Suitable biocides for use in the invention include, but are not limited to complexes of PVP or PVP copolymer with triclosan; diclosan; dichlorophen; orthophenylphenol; orthobenzylparachlorophenol, cresols, xylols, and substituted diphenyl ethers.
US08524796B2 Active polymer compositions
The instant invention generally provides an activated polymer composition containing an active agent (i.e., a chemically- or biologically-active agent), an activated fiber comprising the activated polymer composition, an activated-fiber composite comprising the activated fiber and a fiberweb support, processes of fabricating the activated fiber and activated-fiber composition, and an article comprising the activated polymer composition. The instant invention also generally provides a highly filled polymer filler composite comprising a molecularly self-assembling (MSA) material and a mineral filler or conductive filler dispersed in the MSA material, and a process of making and article comprising the highly filled polymer filler composite.
US08524795B2 Radiation curable ink composition
A radiation curable ink composition has improved adhesion towards rigid recording media, good jetting behavior and no or minimal health and safety risks. The radiation curable ink has a viscosity of 30 mPa·s, or less, at 50° C., has at least two monofunctional monomers, the two monofunctional monomers including a first monomer selected from an N-vinyl amide and a second monofunctional monomer being isobornyl acrylate, a difunctional acrylate monomer being propoxylated (or ethoxylated) neopentyl glycol di acrylate (SR 9003), at least one multifunctional monomer selected from the group consisting of a trifunctional acrylate monomer, a tetrafunctional acrylate monomer, a pentafunctional acrylate monomer, a trifunctional epoxide monomer, a tetrafunctional epoxide monomer, a pentafunctional epoxide monomer, a trifunctional oxetane monomer, a tetrafunctional oxetane monomer, a pentafunctional oxetane monomer, a trifunctional vinylether monomer, a tetrafunctional vinylether monomer and a pentafunctional vinylether monomer, the ink further includes at least one photoinitiator and a colorant.
US08524790B2 Starch film and method for manufacturing starch foam
A biodegradable starch film is provided. The biodegradable starch film includes a starch which is cross-linked by means of a cross-linking agent. The cross-linking agent comprises glycidyl methacrylate (GMA), octenyl succinic anhydride (OSA), or dodecyl succinic anhydride (DDSA) or combinations thereof. The cross-linking agent is 1 to 10 weight parts based on the starch of 100 weight parts. Furthermore, a method for manufacturing starch foam is also provided.
US08524787B2 Process for producing synthetic liquid hydrocarbons and reactor for Fischer-Tropsch synthesis
The disclosure relates to petrochemistry, gas chemistry, coal chemistry, particularly to a synthesis of hydrocarbons C5 and higher from CO and H2 under the Fischer-Tropsch reaction; the invention relates to a process and a system for producing synthetic liquid hydrocarbons. A process for producing synthetic liquid hydrocarbons is provided by catalytic converting syngas under the Fischer-Tropsch reaction on a fixed catalyst bed in a vertical shell and tube reactor with coolant supply into shell wherein as soon as the syngas conversion degree achieves 60-80%, a pressure gradient along the tubes is reduced below 0.1 bar/m and this value is maintained during the whole process. A reactor for Fischer-Tropsch synthesis is provided comprising tubes with catalyst in a shell, the ratio of the tube diameter at the tube outlet to the diameter at the inlet is from 1.5/1 to 2.5/1. The invention gives a possibility to achieve the optimum temperature range in the catalyst bed; it improves heat and mass-transfer and shut out an accumulation of the liquid products in the bottom of the tubes.
US08524786B2 Process for producing fine silver particle colloidal dispersion, fine silver particle colloidal dispersion, and conductive silver film
A process for producing a fine silver particle colloidal dispersion which can simply form conductive silver layers and antimicrobial coatings by screen printing or the like. The process is characterized by having a reaction step of allowing an aqueous silver nitrate solution to react with a mixed solution of an aqueous iron(II) sulfate solution and an aqueous sodium citrate solution to form an agglomerate of fine silver particles, a filtration step of filtering the resultant agglomerate of fine silver particles to obtain a cake of the agglomerate of fine silver particles, a dispersion step of adding pure water to the cake to obtain a first fine silver particle colloidal dispersion of a water system in which dispersion the fine silver particles have been dispersed in the pure water, and a concentration and washing step of concentrating and washing the first fine silver particle colloidal dispersion of a water system.
US08524785B2 Methods for using rebaudioside C as a flavor enhancer
The present invention is directed to the use of one or more rebaudioside C polymorphs, or stereoisomers thereof, to enhance the sweet taste of a flavoring, such as glucosylated steviol glycoside, rebaudioside A, ammoniated glycyrrhizin, neohespherdin dihydrochalcone or thaumatin.
US08524784B2 Polymer micelles containing anthracylines for the treatment of cancer
The present invention provides micelles having an anthracycline encapsulated therein, the micelles comprising a multiblock copolymer. The invention further provides methods of preparing and using said micelles, and compositions thereof.
US08524782B2 Key intermediate for the preparation of Stilbenes, solid forms of Pterostilbene, and methods for making the same
The present invention provides a scalable process for the preparation of stilbenes by (i) condensing 3,5-dialkylbenzyl phosphonates with 4′-O-tetrahydropyranyl benzaldehyde to get 3,5-alkyl-4′-O-tetrahydropyranyl Stilbene and (ii) deprotecting the obtained 3,5-Dialkyl-4′-O-tetrahydropyranylstilbene to yield stilbenes. The present invention also provides a novel intermediate 3,5-Dialkyl-4′-O-tetrahydropyranyl stilbene, which is a key intermediate for the synthesis of stilbenes such as Pterostilbene and Resveratrol. The present invention also provides characteristics of various solid forms of Pterostilbene, methods for their preparation, as well as dosage forms containing the same for administration to or consumption by humans.
US08524778B2 Biphenyl-4-yl-sulfonic acid arylamides and their use as therapeutic agents
The present invention pertains generally to the field of therapeutic compounds, and more specifically to certain aryl sulfonamides and related compounds (collectively referred to herein as ‘BPSAAA compounds’), as described herein, and including, for example, biphenyl-4-sulfonic acid (hydroxyalkyl-phenyl)-amides and related compounds. The present invention also pertains to pharmaceutical compositions comprising such compounds, and the use of such compounds and compositions, both in vitro and in vivo, in treatment and/or prevention, for example, of inflammation and/or joint destruction and/or bone loss; of disorders mediated by excessive and/or inappropriate and/or prolonged activation of the immune system; of, inflammatory and autoimmune disorders, for example, rheumatoid arthritis, psoriasis, psoriatic arthritis, chronic obstructive pulmonary disease (COPD), atherosclerosis, inflammatory bowel disease, ankylosing spondylitis, and the like; of disorders associated with bone loss, such as bone loss associated with excessive osteoclast activation in rheumatoid arthritis, osteoporosis, cancer associated bone disease, Paget's disease and the like.
US08524775B2 Sulfoperoxycarboxylic acids, their preparation and methods of use as bleaching and antimicrobial agents (PSOA)
The present invention relates to novel sulfoperoxycarboxylic acid compounds, and methods for making and using them. The sulfoperoxycarboxylic compounds of the invention are storage stable, water soluble and have low to no odor. Further, the compounds of the present invention can be formed from non-petroleum based renewable materials. The compounds of the present invention can be used as antimicrobials, and bleaching agents. The compounds of the present invention are also suitable for use as coupling agents.
US08524765B2 Compounds that modulate intracellular calcium
Described herein are compounds and pharmaceutical compositions containing compounds of Formula (I), which modulate the activity of store-operated calcium (SOC) channels: wherein R1, R2 and R4 are defined herein. Also described herein are methods of using such SOC channel modulators, alone and in combination with other compounds, for treating diseases or conditions that would benefit from inhibition of SOC channel activity.
US08524764B2 Inhibitors of Flaviviridae viruses
Provided are compounds of Formula I: and pharmaceutically acceptable salts and esters thereof. The compounds, compositions, and methods provided are useful for the treatment of Flaviviridae virus infections, particularly hepatitis C infections.
US08524761B2 Phenoxy-pyrrolidine derivative and its use and compositions
The present invention is directed to the compound 2-(4-(hydroxymethyl)phenoxy)-1-(3-(2-(trifluoromethyl)phenoxy)pyrrolidin-1-yl)ethanone, its use as an inhibitor of stearoyl CoA desaturase and to pharmaceutical compositions containing this compound.
US08524759B2 Phenylbutazone carrier formulation showing increased bioactivity in animals
An improved phenylbutazone carrier composition provides increased palatability to horses. Additionally, the composition improves the bioavailability of the phenylbutazone and thus increases the horse's blood plasma levels of the medicine for the same effective dosage of the medicine.
US08524755B2 Specific diarylhydantoin and diarylthiohydantoin compounds
Compositions, such as pharmaceutical compositions, comprising specific diarylhydantoin and diarylthiohydantoin compounds, or salts or solvates thereof, are provided. Isolated and purified forms of the compounds are also described, as are unit dosage forms, compositions of substantially pure compound and kits comprising the compounds. The compounds and pharmaceutical compositions thereof may find use in the prevention and/or treatment of a variety of conditions, including prostate cancer, Parkinson's disease, Alzheimer's disease, and others.
US08524754B2 Polymorphic, crystalline and mesophase forms of sodium 2-(5-bromo-4-(4-cyclopropylnaphthalen-1-yl)-4H-1,2,4-triazol-3-ylthio) acetate, and uses thereof
Crystalline polymorphs and solid mesophase forms of sodium 2-(5-bromo-4-(4-cyclopropylnaphthalen-1-yl)-4H-1,2,4-triazol-3-ylthio)acetate are described. In addition, pharmaceutical compositions and uses of such compositions for the treatment of a variety of diseases and conditions are provided.
US08524750B2 (Pyrazol-3-yl)-1,3,4-thiadiazol-2-amine and (pyrazol-3-yl)-1,3,4-thiazol-2-amine compounds
A compound of Formula (I) wherein: either X is N and Y is CR5 or X is C and Y is S; Z is selected from N and CH; R1 is selected from H and Me; R2 is selected from H, OH, OMe and Me; each R3 is independently selected from C1-3alkyl, F, Cl, Br, CF3 and NH2; R4 is selected from Me, CF3, NO2 and CHF2; R5 is selected from H, Me and CHF2; R6 is selected from H and Me; and p is 0-3, compositions containing them, their use in therapy, for example in the treatment of tuberculosis, and methods for the preparation of such compounds, are provided.
US08524741B2 Compositions and methods relating to solenopsins and their uses in treating neurological disorders and enhancing cognitive and physical performance
Provided herein are piperidine alkaloids and uses thereof in neurological disorders and physical enhancement applications.
US08524735B2 Aerosolized fluoroquinolones and uses thereof
Disclosed herein are formulations of fluoroquinolones suitable for aerosolization and use of such formulations for aerosol administration of fluoroquinolone antimicrobials for the treatment of pulmonary bacterial infections. In particular, inhaled levofloxacin specifically formulated and delivered for bacterial infections of the lungs is described. Methods include inhalation protocols and manufacturing procedures for production and use of the compositions described.
US08524734B2 Aerosolized fluoroquinolones and uses thereof
Disclosed herein are formulations of fluoroquinolones suitable for aerosolization and use of such formulations for aerosol administration of fluoroquinolone antimicrobials for the treatment of pulmonary bacterial infections. In particular, inhaled levofloxacin specifically formulated and delivered for bacterial infections of the lungs is described. Methods include inhalation protocols and manufacturing procedures for production and use of the compositions described.
US08524730B2 Spirochromanone carboxylic acids
The invention relates to a compound of a general formula (I): wherein A represents a linking group; Ar1 represents a group formed from an aromatic ring; R1 and R2 each independently represent a hydrogen atom, a halogen atom, a cyano group, a C2-C6 alkenyl group, a C1-C6 alkoxy group, a halo-C1-C6 alkoxy group, a cyclo-C3-C6 alkyloxy group, a C2-C7 alkanoyl group, a halo-C2-C7 alkanoyl group, a C2-C7 alkoxycarbonyl group, a halo-C2-C7 alkoxycarbonyl group, a cyclo-C3-C6 alkyloxycarbonyl group, an aralkyloxycarbonyl group, a carbamoyl-C1-C6 alkoxy group, a carboxy-C2-C6 alkenyl group, or a group of -Q1-N(Ra)-Q2-Rb; a C1-C6 alkyl group optionally having substituent(s); an aryl or heterocyclic group optionally having substituent(s); or a C1-C6 alkyl group or a C2-C6 alkenyl group having the aryl or heterocyclic group; T and U each independently represent a nitrogen atom or a methine group; and V represents an oxygen atom, a sulfur atom or an imino group. The compound of the invention is useful as therapeutical agents for various ACC-related diseases.
US08524726B2 Amido derivatives and their use as positive allosteric modulators of metabotropic glutamate receptors
The present invention relates to novel compounds of Formula (I), wherein X1, X2, X3, X4, Am and Bn are defined as in Formula (I); invention compounds are modulators of metabotropic glutamate receptors—subtype 4 (“mGluR4”) which are useful for the treatment or prevention of central nervous system disorders as well as other disorders modulated by mGluR4 receptors. The invention is also directed to pharmaceutical compositions and the use of such compounds in the manufacture of medicaments, as well as to the use of such compounds for the prevention and treatment of such diseases in which mGluR4 is involved.
US08524720B2 Substituted N-(pyrazol-5-yl)-pyrrolo[3,2-D]pyrimidin-4-amine useful as protein kinase inhibitors
This invention describes novel pyrazole compounds of formula IV: wherein Ring D is a 5-7 membered monocyclic ring or 8-10 membered bicyclic ring selected from aryl, heteroaryl, heterocyclyl or carbocyclyl; Rx and Ry are independently selected from T-R3, or taken together with their intervening atoms to form a fused, unsaturated or partially unsaturated, 5-8 membered ring having 1-3 ring heteroatoms selected from oxygen, sulfur, or nitrogen; and R2, R2′, T, and R3 are as described in the specification. The compounds are useful as protein kinase inhibitors, especially as inhibitors of aurora-2 and GSK-3, for treating diseases such as cancer, diabetes and Alzheimer's disease.
US08524717B2 Oxidase inhibitors and their use
The invention relates to phenylcyclopropylamine acetamide derivatives and their use in treating diseases.
US08524714B2 7-phenylalkyl substituted 2-quinolinones and 2-quinoxalinones as poly(ADP-ribose) polymerase inhibitors
The present invention provides compounds of formula (I), their use as PARP inhibitors as well as pharmaceutical compositions comprising said compounds of formula (I) wherein n, R1, R2, R3, R4, R5, R6 and X have defined meanings.
US08524708B2 Oxadiazoanthracene compounds for the treatment of diabetes
The present invention provides methods of use of oxadiazoanthracene derivatives of the formula (I) and pharmaceutically acceptable salts thereof, wherein A, B, C, R, R1, R2, R3, R4 and R5 are as herein described, and wherein said methods of use include uses for the treatment and/or prevention of disorders and diseases, such as diabetes.
US08524706B2 1,4-diazabicyclo[3.2.2]nonanecarboxamide derivatives, preparation and therapeutic use thereof
The present invention discloses and claims compounds of general formula in which X, R1, P, Q, R and W are as described herein. The compounds of the invention are useful in a variety of therapeutic applications.
US08524704B2 Azepinoindole derivatives as pharmaceutical agents
Compounds, compositions and methods for modulating the activity of receptors are provided. In particular, compounds and compositions are provided for modulating the activity of receptors and for the treatment, prevention, or amelioration of one or more symptoms of disease or disorder directly or indirectly related to the activity of the receptors.
US08524703B2 Bridgehead amine ring-fused indoles and indolines
The present application relates to indole and indoline derivatives of formula (I), formula (II), formula (III), or formula (IV) wherein a, R2, R3, h, k, m, n, L, Q, X, and Z are as defined in the specification. The present application also relates to compositions comprising such compounds, and methods of treating disease conditions using such compounds and compositions.
US08524699B2 Substituted dihydropyrazolones and use thereof as HIF-prolyl-4-hydroxylase inhibitors
The present application relates to novel substituted dihydropyrazolone derivatives, processes for their preparation, their use for treatment and/or prophylaxis of diseases and their use for the preparation of medicaments for treatment and/or prophylaxis of diseases, in particular cardiovascular and hematological diseases and kidney diseases, and for promoting wound healing.
US08524691B2 Phosphonated rifamycins and uses thereof for the prevention and treatment of bone and joint infections
The present invention relates to phosphonated Rifamycins, and methods of making and using such compounds. These compounds are useful as antibiotics for prophylaxis and/or the treatment of bone and joint infections, especially for the prophylaxis and/or treatment of osteomyelitis.
US08524688B2 Use of sulfated glycosaminoglycans for establishing effective labor in women
A method of treating protracted labor in a pregnant woman comprises administering to a pregnant woman an effective amount of a depolymerized low molecular weight heparin treated with periodate to eradicate antithrombin III binding affinities, thereby exhibiting an anticoagulant activity of 10 BP units/mg or less and an average molecular weight not higher than 10000 Da to prime or curatively treat the cervix and myometrium and for treatment of slow progress of labor. A method for prophylactic priming or curative treatment of the cervix and the myometrium for establishing effective labor in a pregnant woman comprises administering to a pregnant woman an effective amount of a depolymerized low molecular weight heparin as described to prophylactically prime or curatively treat the cervix and myometrium and for establishing effective labor in the pregnant woman.
US08524677B2 DNA vaccine as immunoprophylaxis against Kala-azar
A highly conserved membrane protein present in all species of Leishmania can be used as a vaccine antigen for genetic immunization against visceral leishmananiasis.
US08524676B2 Method for treating enterovirus or rhinovirus infection using antisense antiviral compounds
The invention provides antisense antiviral compounds and methods of their use and production in inhibition of growth of viruses of the Picornaviridae family and in the treatment of a viral infection. The compounds are particularly useful in the treatment of Enterovirus and/or Rhinovirus infection in a mammal. The antisense antiviral compounds are substantially uncharged, morpholino oligonucleotides have a sequence of 12-40 subunits, including at least 12 subunits having a targeting sequence that is complementary to a region associated with viral RNA sequences within a 32 nucleotide region of the viral 5′ untranslated region identified by SEQ ID NO:7.
US08524666B2 Methods of using vimentin to inhibit angiogenesis and endothelial cell proliferation
The invention relates to a method of treatment for states related to inhibition of angiogenesis and endothelial cell proliferation comprising administering an effective amount of vimentin or its derivatives or its fragments, to a subject in need thereof. Further, the invention relates to a pharmaceutical composition and a medicament comprising vimentin, as well as the use of vimentin in the manufacture of a medicament. Hereby, angiogenesis and endothelial cell proliferation can be controlled, and therapeutic treatment for related states is provided.
US08524665B2 Use of secretin in treatments of disorders associated with the amygdala
In general, the present invention provides methods for treating disorders associated with the amygdala. The methods of treatment are based on the administration of a therapeutically effective amount of secretin to an individual suffering from a disorder associated with the amygdala, e.g., bipolar disorder or a substance use disorder.
US08524661B2 Inhibiting serum response factor (SRF) to improve glycemic control
Described are methods of improving glycemic control/improving insulin sensitivity by administering an inhibitor of serum response factor (SRF) activity, and methods of identifying new compounds for use in the described methods of treatment.
US08524656B2 GM-CSF and truncated CCL2 conjugates and methods and uses thereof
A conjugate protein comprising a GM-CSF or a fragment thereof and a truncated CCL2 is described. The conjugate protein has unexpected immune suppressive, anti-obesity and tumoricidal properties and is useful in a variety of therapeutic applications.
US08524655B2 Use of SCF and G-CSF in the treatment of cerebral ischemia and neurological disorders
The present invention relates to the use of stem cell factor (SCF) polypeptide, alone and in combination with granulocyte colony stimulating factor (G-CSF) polypeptide, in the prevention or treatment of injury to the brain after cerebral ischemia or neurological disorder. More particularly, the invention provides methods of improving neurological function and outcome after stroke by the administration of SCF polypeptide, alone and in combination with G-CSF polypeptide. This treatment can be used alone or in combination with other well-known methods of treatment of cerebral ischemia and neurological disorders in a mammal.
US08524653B2 Peptidomimetic macrocycles
Biologically active crosslinked polypeptides with improved properties relative to their corresponding precursor polypeptides, having good cell penetration properties and reduced binding to human proteins, and methods of identifying and making such improved polypeptides are described.
US08524636B2 Synergistic combination of a glyphosate compound and IPBC
A synergistic antimicrobial composition containing a glyphosate compound and 3-iodo-2-propynyl-butylcarbamate is provided. Also provided is a method of inhibiting the growth of or controlling the growth of microorganisms in a building material by adding such a synergistic antimicrobial composition. Also provided is a coating composition containing such a synergistic antimicrobial composition, and a dry film made from such a coating composition. Also provided is a method of making zinc glyphosate.
US08524630B2 Mesoporous aluminas stabilized with rare earth and phosphorous
A mesoporous oxide composition includes, other than oxygen, a major amount of aluminum and lesser amounts of phosphorus and at least one rare earth element. The compositions have high surface area and excellent thermal and hydrothermal stability, with a relatively narrow pore size distribution in the mesoporous range. These compositions may be prepared by a hydrothermal co-precipitation method using an organic templating agent. These mesoporous oxide compositions may be used as catalysts or as supports for catalysts, for example, in a fluid catalytic cracking process.
US08524629B2 Catalysts
Presented are one or more aspects and/or one or more embodiments of catalysts, methods of preparation of catalyst, methods of deoxygenation, and methods of fuel production.
US08524628B2 Phosphorus-containing catalyst composition and hydroformylation process using the same
Provided are a catalyst composition comprising a bidentate ligand, a monodentate ligand, and a transition metal catalyst and a process of hydroformylation of olefin compounds, comprising reacting the olefin compound with a gas mixture of hydrogen and carbon monoxide while being stirred at elevated pressures and temperatures in the presence of the catalyst composition to produce an aldehyde. The catalytic composition demonstrates the high catalytic activity and option control of selectivity to normal aldehyde or iso aldehyde (N/I selectivity) to a desired value.
US08524620B2 Environmentally stable hybrid fabric system for exterior protection of an aircraft
A method of forming an exterior surface protective structure (12) for an aircraft (10) includes uniting a loaded surfacer (52) having a carrier (51) to a hybrid prepreg substrate (32). The prepreg substrate (32) includes a carbon fabric (44) with an integral conductive component (48) having conductivity with in a metal conductivity range and is united to a base substrate (30). The loaded surfacer (52) and the prepreg substrate (32) are cured, which includes interfacially adhering matter between the loaded surfacer (52) and the prepreg substrate (32). A protective fabric system (12) for an exterior (14) of an aircraft (10) includes the base substrate (30). The hybrid prepreg substrate (32) is coupled to the base substrate (30). The loaded surfacer (52) with the carrier (51) is interfacially adhered to the prepreg substrate (32).
US08524619B2 Method for fabricating semiconductor device including performing oxygen plasma treatment
A method for fabricating a semiconductor device including performing oxygen plasma treatment to a surface of a nitride semiconductor layer, a power density of the oxygen plasma treatment being 0.2 to 0.3 W/cm2.
US08524618B2 Hafnium tantalum oxide dielectrics
A dielectric layer containing a hafnium tantalum oxide film and a method of fabricating such a dielectric layer produce a dielectric layer for use in a variety of electronic devices. Embodiments include structures for capacitors, transistors, memory devices, and electronic systems with dielectric layers containing a hafnium tantalum oxide film structured as one or more monolayers.
US08524615B2 Method of forming hardened porous dielectric layer and method of fabricating semiconductor device having hardened porous dielectric layer
Example embodiments relate to a method of forming a hardened porous dielectric layer. The method may include forming a dielectric layer containing porogens on a substrate, transforming the dielectric layer into a porous dielectric layer using a first UV curing process to remove the porogens from the dielectric layer, and transforming the porous dielectric layer into a crosslinked porous dielectric layer using a second UV curing process to generate crosslinks in the porous dielectric layer.
US08524613B1 Densely-packed films of lanthanide oxide nanoparticles via electrophoretic deposition
A method of forming a film of lanthanide oxide nanoparticles. In one embodiment, the method includes the steps of: (a) providing a first substrate with a conducting surface and a second substrate that is positioned apart from the first substrate, (b) applying a voltage between the first substrate and the second substrate, (c) immersing the first and the second substrates in a solution that comprises a plurality of lanthanide oxide nanoparticles suspended in a non-polar solvent or apolar solvent for a first duration of time effective to form a film of lanthanide oxide nanoparticles on the conducting surface of the first substrate, and (d) after the immersing step, removing the first substrate from the solution and exposing the first substrate to air while maintaining the applied voltage for a second duration of time to dry the film of lanthanide oxide nanoparticles formed on the conducting surface of the first substrate.
US08524612B2 Plasma-activated deposition of conformal films
Embodiments related to depositing thin conformal films using plasma-activated conformal film deposition (CFD) processes are described herein. In one example, a method of processing a substrate includes, applying photoresist to the substrate, exposing the photoresist to light via a stepper, patterning the resist with a pattern and transferring the pattern to the substrate, selectively removing photoresist from the substrate, placing the substrate into a process station, and, in the process station, in a first phase, generating radicals off of the substrate and adsorbing the radicals to the substrate to form active species, in a first purge phase, purging the process station, in a second phase, supplying a reactive plasma to the surface, the reactive plasma configured to react with the active species and generate the film, and in a second purge phase, purging the process station.
US08524611B2 Method and apparatus for inline deposition of materials on a non-planar surface
In manufacturing a semiconductor device, a first chamber is provided. An opening couples the first chamber to a first environment through which at least one substrate can pass. A first seal environmentally isolates the first chamber from the first environment. A process chamber is coupled to the first chamber. Another seal environmental isolates the first and the process chambers. The substrate is placed within the first chamber, and the first chamber and the outside environment are isolated. The second opening is opened, and the substrate moves into the semiconductor process chamber. The first chamber is again environmentally isolated from the second volume. A semiconductor processing step is performed on the substrate within the processing chamber. While the substrate is processed, the substrate is rotated and translated through the processing chamber.
US08524605B1 Fabrication and mask design methods using spatial frequency sextupling technique
Self-aligned sextuple patterning (SASP) processes and mask design methods for the semiconductor manufacturing are invented. The inventions pertain to methods of forming one and/or two dimensional features on a substrate having the feature density increased to six times of what is possible using the standard optical lithographic technique; and methods to release the overlay requirement when patterning the critical layers of semiconductor devices. Our inventions provide production-worthy methods for the semiconductor industry to continue device scaling beyond 15 nm (half pitch).
US08524604B2 Method for forming fine pattern of semiconductor device
A method for forming fine pattern includes sequentially forming a first thin film and a second thin film over a target layer for patterning, forming a partition over the second thin film, removing the partition after forming spacers on sidewalls of the partition, forming first pattern of the second thin film by etching the second thin film of a first region and the second thin film of a second region while exposing the spacers, forming second pattern of the second thin film by using the spacers as masks and etching the first pattern of the second thin film in the first region, forming first thin film pattern by using the first and second patterns of the second thin film as masks in the first and second regions and etching the first thin film, and etching the pattern target layer.
US08524599B2 Methods of forming at least one conductive element and methods of forming a semiconductor structure
Methods of forming conductive elements, such as interconnects and electrodes, for semiconductor structures and memory cells. The methods include forming a first conductive material and a second conductive material comprising silver in a portion of at least one opening and performing a polishing process to fill the at least one opening with at least one of the first and second conductive materials. An annealing process may be performed to form a mixture or an alloy of the silver and the first conductive material. The methods enable formation of silver containing conductive elements having reduced dimensions (e.g., less than about 20 nm). The resulting conductive elements have a desirable resistivity. The methods may be used, for example, to form interconnects for electrically connecting active devices and to form electrodes for memory cells. A semiconductor structure and a memory cell including such a conductive structure are also disclosed.
US08524597B2 Methods for forming planarized hermetic barrier layers and structures formed thereby
Methods and associated structures of forming a microelectronic structure are described. Those methods may comprise forming a conductive material in an interconnect opening within an interlayer dielectric material that is disposed on a substrate, forming a low density dielectric material on a surface of the dielectric layer and on a surface of the conductive material, and forming a high density dielectric barrier layer on the low density dielectric layer.
US08524594B2 Solid-state imaging device, method for manufacturing the same, and electronic apparatus
A method for manufacturing a solid-state imaging device includes: forming pixels that receive incident light in a pixel array area of a substrate; forming pad electrodes in a peripheral area located around the pixel array area of the substrate; forming a carbon-based inorganic film on an upper surface of each of the pad electrodes including a connection surface electrically connected to an external component; forming a coated film that covers upper surfaces of the carbon-based inorganic films; and forming an opening above the connection surface of each of the pad electrodes to expose the connection surface.
US08524593B2 Arrangement for solder bump formation on wafers
An apparatus and a process for the manufacture of a solder-bump adhered wafer substrate for use in the semiconductor industry, comprising one or more of the following steps including: arranging a first compressive member and a second compressive member in an opposed, compressibly displaceable, spaced-apart relationship, with a pattern plate disposed therebetween with the pattern plate having a plurality of aligned through-holes arranged thereon; filling the through-holes with a molten solder; compressing the solder and the pattern plate between the first and second opposed compressive members to compact the solder therein and cleans the pattern plate of excess solder; chilling the pattern plate to solidify the molten solder in the through-holes; and removing the pattern plate from the spaced-apart compressive members to produce a wafer with solder bumps thereon.
US08524588B2 Method of forming a single metal that performs N work function and P work function in a high-k/metal gate process
The present disclosure provides a method of fabricating a semiconductor device. The method includes forming a gate dielectric over a semiconductor substrate, forming a capping layer over or under the gate dielectric, forming a metal layer over the capping layer, the metal layer having a first work function, treating a portion of the metal layer such that a work function of the portion of the metal layer changes from the first work function to a second work function, and forming a first metal gate from the untreated portion of the metal layer having the first work function and forming a second metal gate from the treated portion of the metal layer having the second work function.
US08524585B2 Method of manufacturing semiconductor device
A method of manufacturing a MOSFET includes the steps of preparing a substrate with an epitaxial growth layer made of silicon carbide, performing ion implantation into the substrate with the epitaxial growth layer, forming a protective film made of silicon dioxide on the substrate with the epitaxial growth layer into which the ion implantation was performed, and heating the substrate with the epitaxial growth layer on which the protective film was formed to a temperature range of 1600° C. or more in an atmosphere containing gas including an oxygen atom.
US08524582B2 Silicon-germanium hydrides and methods for making and using same
The present invention provides novel silicon-germanium hydride compounds, methods for their synthesis, methods for their deposition, and semiconductor structures made using the novel compounds.
US08524581B2 GaN epitaxy with migration enhancement and surface energy modification
Methods and apparatus for depositing thin films incorporating the use of a surfactant are described. Methods and apparatuses include a deposition process and system comprising multiple isolated processing regions which enables rapid repetition of sub-monolayer deposition of thin films. The use of surfactants allows the deposition of high quality epitaxial films at lower temperatures having low values of surface roughness. The deposition of Group III-V thin films such as GaN is used as an example.
US08524573B2 Method for separating a semiconductor layer from a substrate by irradiating with laser pulses
A method for producing a semiconductor component, in which a semiconductor layer is separated from a substrate by irradiation with laser pulses, the pulse duration of the laser pulses being less than or equal to 10 ns. The laser pulses have a spatial beam profile with a flank slope is chosen to be gentle enough to prevent cracks in the semiconductor layer that arise as a result of thermally induced lateral stresses during the separation of semiconductor layer and substrate.
US08524572B2 Methods of processing units comprising crystalline materials, and methods of forming semiconductor-on-insulator constructions
Some embodiments include methods of processing a unit containing crystalline material. A damage region may be formed within the crystalline material, and a portion of the unit may be above the damage region. A chuck may be used to bend the unit and thereby induce cleavage along the damage region to form a structure from the portion of the unit above the damage region. Some embodiments include methods of forming semiconductor-on-insulator constructions. A unit may be formed to have dielectric material over monocrystalline semiconductor material. A damage region may be formed within the monocrystalline semiconductor material, and a portion of the monocrystalline semiconductor material may be between the damage region and the dielectric material. The unit may be incorporated into an assembly with a handle component, and a chuck may be used to contort the assembly and thereby induce cleavage along the damage region.
US08524568B2 Semiconductor device having capacitor capable of reducing additional processes and its manufacture method
A first capacitor recess and a wiring trench are formed through an interlayer insulating film. A lower electrode fills the first capacitor recess, and a first wiring fills the wiring trench. An etching stopper film and a via layer insulating film are disposed over the interlayer insulating film. A first via hole extends through the via layer insulating film and etching stopper film and reaches the first wiring, and a first plug fills the first via hole. A second capacitor recess is formed through the via layer insulating film, the second capacitor recess at least partially overlapping the lower electrode, as viewed in plan. The upper electrode covers the bottom and side surfaces of the second capacitor recess. A capacitor is constituted of the upper electrode, etching stopper film and lower electrode. A second wring connected to the first plug is formed over the via layer insulating film.
US08524567B2 Semiconductor fuse with enhanced post-programming resistance
Post programming resistance of a semiconductor fuse is enhanced by using an implantation to form an amorphous silicon layer and to break up an underlying high-κ/metal gate. Embodiments include forming a shallow trench isolation (STI) region in a silicon substrate, forming a high-κ dielectric layer on the STI region, forming a metal gate on the high-κ dielectric layer, forming a polysilicon layer over the metal gate, performing an implantation to convert the polysilicon layer into an amorphous silicon layer, wherein the implantation breaks up the metal gate, and forming a silicide on the amorphous silicon layer. By breaking up the metal gate, electrical connection of the fuse contacts through the metal gate is eliminated.
US08524566B2 Methods for the fabrication of integrated circuits including back-etching of raised conductive structures
Embodiments of a method for fabricating an integrated circuit are provided. In one embodiment, the method includes producing a partially-completed semiconductor device including a substrate, source/drain (S/D) regions, a channel region between the S/D regions, and a gate stack over the channel region. At least one raised electrically-conductive structure is formed over at least one of the S/D regions and separated from the gate stack by a lateral gap. The raised electrically-conductive structure is then back-etched to increase the width of the lateral gap and reduce the parasitic fringing capacitance between the raised electrically-conductive structure and the gate stack during operation of the completed semiconductor device.
US08524565B2 Semiconductor device and method for forming the same
A method for forming a semiconductor device is provided, wherein a step of forming an S/D region comprises: determining an interface region comprising an active region of a partial width abutting an isolation region, and forming an auxiliary layer covering the interface region; removing a semiconductor substrate of a partial thickness in the active region using the auxiliary layer, a gate stack structure and the isolation region as a mask, so as to form a groove; and growing a semiconductor material in the groove for filling into the groove. A semiconductor device having a material of the semiconductor substrate sandwiched between an S/D region and an isolation region is further provided. The present invention is beneficial to reduce current leakage.
US08524561B2 Methods of forming a plurality of transistor gates, and methods of forming a plurality of transistor gates having at least two different work functions
A method of forming a plurality of transistor gates having at least two different work functions includes forming first and second transistor gates over a substrate having different widths, with the first width being narrower than the second width. A material is deposited over the substrate including over the first and second gates. Within an etch chamber, the material is etched from over both the first and second gates to expose conductive material of the first gate and to reduce thickness of the material received over the second gate yet leave the second gate covered by the material. In situ within the etch chamber after the etching, the substrate is subjected to a plasma comprising a metal at a substrate temperature of at least 300° C. to diffuse said metal into the first gate to modify work function of the first gate as compared to work function of the second gate.
US08524556B1 Resistor and manufacturing method thereof
A method of manufacturing a resistor integrated with a transistor having metal gate includes providing a substrate having a transistor region and a resistor region defined thereon, a transistor is positioned in the transistor region and a resistor is positioned in the resistor region; forming a dielectric layer exposing tops of the transistor and the resistor on the substrate; performing a first etching process to remove portions of the resistor to form two first trenches respectively at two opposite ends of the resistor; forming a patterned protecting layer in the resistor region; performing a second etching process to remove a dummy gate of the transistor to form a second trench in the transistor region; and forming a metal layer filling the first trenches and the second trench.
US08524552B2 Normally-off power JFET and manufacturing method thereof
In general, in a semiconductor active element such as a normally-off JFET based on SiC in which an impurity diffusion speed is significantly lower than in silicon, gate regions are formed through ion implantation into the side walls of trenches formed in source regions. However, to ensure the performance of the JFET, it is necessary to control the area between the gate regions thereof with high precision. Besides, there is such a problem that, since a heavily doped PN junction is formed by forming the gate regions in the source regions, an increase in junction current cannot be avoided. The present invention provides a normally-off power JFET and a manufacturing method thereof and forms the gate regions according to a multi-epitaxial method which repeats a process including epitaxial growth, ion implantation, and activation annealing a plurality of times.
US08524551B2 Method of manufacturing heterojunction bipolar transistor and heterojunction bipolar transistor
A method of forming a heterojunction bipolar transistor by depositing a first stack comprising an polysilicon layer and a sacrificial layer on a mono-crystalline silicon substrate surface; patterning that stack to form a trench extending to the substrate; depositing a silicon layer over the resultant structure; depositing a silicon-germanium-carbon layer over the resultant structure; selectively removing the silicon-germanium-carbon layer from the sidewalls of the trench; depositing a boron-doped silicon-germanium-carbon layer over the resultant structure; depositing a further silicon-germanium-carbon layer over the resultant structure; depositing a boron-doped further silicon layer over the resultant structure; forming dielectric spacers on the trench sidewalls; filling the trench with emitter material; exposing polysilicon regions outside the trench side walls by selectively removing the sacrificial layer; implanting boron impurities into the exposed polysilicon regions to define base implants; and exposing the resultant structure to a thermal budget for annealing the boron impurities.
US08524550B2 Method of manufacturing semiconductor device and semiconductor device
A method of manufacturing a semiconductor device, in which a second semiconductor layer of AlxGa1-x-yInyN (wherein x, y, and x+y satisfy x>0, y≧0, and x+y≦1, respectively) on a first semiconductor layer of GaN by hetero-epitaxial growth using a MOCVD method, the method including the steps of: (a) supplying N source gas and Ga source gas to form the first semiconductor layer; (b) supplying the N source gas without supplying the Ga source gas and Al source gas, after step (a); (c) supplying the N source gas and the Al source gas without supplying the Ga source gas, after step (b); and (d) supplying the N source gas, the Ga source gas and the Al source gas to form the second semiconductor layer, after step (c).
US08524548B2 DMOS Transistor with a cavity that lies below the drift region
A lateral DMOS transistor formed on a silicon-on-insulator (SOI) structure has a higher breakdown voltage that results from a cavity that is formed in the bulk region of the SOI structure. The cavity exposes a portion of the bottom surface of the insulator layer of the SOI structure that lies directly vertically below the drift region of the DMOS transistor.
US08524547B2 Fin-type field effect transistor
Disclosed herein are improved fin-type field effect transistor (FinFET) structures and the associated methods of manufacturing the structures. In one embodiment FinFET drive current is optimized by configuring the FinFET asymmetrically to decrease fin resistance between the gate and the source region and to decrease capacitance between the gate and the drain region. In another embodiment device destruction at high voltages is prevented by ballasting the FinFET. Specifically, resistance is optimized in the fin between the gate and both the source and drain regions (e.g., by increasing fin length, by blocking source/drain implant from the fin, and by blocking silicide formation on the top surface of the fin) so that the FinFET is operable at a predetermined maximum voltage.
US08524541B2 Processes for manufacturing an LED package with top and bottom electrodes
An LED package with an extended top electrode and an extended bottom electrode is made from a single metal sheet, one manufacturing process embodiment includes: preparing a piece of single metal sheet, forming a first metal and a coplanar second metal, mounting an LED on an inner end of the first metal, wire-bonding top electrode to an inner end of the second metal, encapsulating at least the LED and the bonding wire with a protection glue, bending an outer end of the first metal upward twice 90 degrees to form a top flat as an extended top electrode of the package, and bending an outer end of the second metal downward twice 90 degrees to form a bottom flat as an extended bottom electrode of the package.
US08524537B2 Semiconductor device and method of forming protective coating material over semiconductor wafer to reduce lamination tape residue
A semiconductor device has a build-up interconnect structure formed over an active surface of a semiconductor wafer containing a plurality of semiconductor die separated by a saw street. An insulating layer is formed over the interconnect structure. Bumps are formed over the interconnect structure. A protective coating material is deposited over the insulating layer and saw street. A lamination tape is applied over the coating material. A portion of a back surface of the semiconductor wafer is removed. A mounting tape is applied over the back surface. The lamination tape is removed while leaving the coating material over the insulating layer and saw street. A first channel is formed through the saw street extending partially through the semiconductor wafer. The coating material is removed after forming the first channel. A second channel is formed through the saw street and the mounting tape is removed to singulate the semiconductor wafer.
US08524536B2 Optical film cutting method and apparatus using the same
Nip rollers 11 and 12 each including a pair of upper and lower rollers are disposed on an upstream side and a downstream side with a portion to be cut of an optical film F located therebetween. In the nip roller 12, a center axis C of the upper roller 12b is displaced relative to a center axis L of the drive roller 12a in a direction away from the portion to be cut. Upon cutting of the polarizing film F, the upper rollers 11b and 12b are simultaneously moved downward, so that a timing at which the downstream nip roller 12 nips the polarizing film F is delayed. Further, the nip roller 12 pulls the polarizing film F in the direction away from the portion to be cut, so that tension is applied to the polarizing film F. In this state, the polarizing film F is cut by a laser device 10.
US08524534B2 Semiconductor device and manufacturing method thereof
Of three chips (2A), (2B), and (2C) mounted on a main surface of a package substrate (1) in a multi-chip module (MCM), a chip (2A) with a DRAM formed thereon and a chip (2B) with a flash memory formed thereon are electrically connected to wiring lines (5) of the package substrate (1) through Au bumps (4), and a gap formed between main surfaces (lower surfaces) of the chips (2A), (2B) and a main surface of the package substrate (1) is filled with an under-fill resin (6). A chip (2C) with a high-speed microprocessor formed thereon is mounted over the two chips (2A) and (2B) and is electrically connected to bonding pads (9) of the package substrate (1) through Au wires (8).
US08524532B1 Integrated circuit package including an embedded power stage wherein a first field effect transistor (FET) and a second FET are electrically coupled therein
One aspect of the invention pertains to an integrated circuit package with an embedded power stage. The integrated circuit package includes a first field effect transistor (FET) and a second FET that are electrically coupled with one another. The FETs are embedded in a dielectric substrate that is formed from multiple dielectric layers. The dielectric layers are laminated together with one or more foil layers that help form an electrical interconnect for the package. Various embodiments relate to method of forming the above package.
US08524525B2 Joined nanostructures and methods therefor
Nanostructures are joined using one or more of a variety of materials and approaches. As consistent with various example embodiments, two or more nanostructures are joined at a junction between the nanostructures. The nanostructures may touch or be nearly touching at the junction, and a joining material is deposited and nucleates at the junction to couple the nanostructures together. In various applications, the nucleated joining material facilitates conductivity (thermal and/or electric) between the nanostructures. In some embodiments, the joining material further enhances conductivity of the nanostructures themselves, such as by growing along the nanostructures and/or doping the nanostructures.
US08524523B2 Square pillar-shaped switching element for memory device and method of manufacturing the same
A switching element for a memory device includes a base layer including a plurality of line-type trenches. First insulation patterns are formed on the base layer excluding the trenches. First diode portions are formed on the bottoms of the trenches in the form of a thin film. Second insulation patterns are formed on the first diode portions and are spaced apart from each other to form holes in the trenches having the first diode portions provided therein. Square pillar-shaped second diode portions are formed in the holes over the first diode portions.
US08524522B2 Microelectronic device, in particular back side illuminated image sensor, and production process
A process for producing a microelectronic device includes producing a first semiconductor substrate which includes a first layer and a second layer present between a first side and a second side of the substrate. First electronic components and an interconnecting part are produced on and above the second side. The substrate is then thinned by a first selective etch applied from the first side and stopping on the first layer followed by a second selective etch stopping on the second layer. A second substrate is attached over the interconnecting part. The electronic components may comprise optoelectronic devices which are illuminated through the second layer.
US08524518B2 Epitaxial formation support structures and associated methods
Epitaxial formation support structures and associated methods of manufacturing epitaxial formation support structures and solid state lighting devices are disclosed herein. In several embodiments, a method of manufacturing an epitaxial formation support substrate can include forming an uncured support substrate that has a first side, a second side opposite the first side, and coefficient of thermal expansion substantially similar to N-type gallium nitride. The method can further include positioning the first side of the uncured support substrate on a first surface of a first reference plate and positioning a second surface of a second reference plate on the second side to form a stack. The first and second surfaces can include uniformly flat portions. The method can also include firing the stack to sinter the uncured support substrate. At least side of the support substrate can form a planar surface that is substantially uniformly flat.
US08524515B2 Semiconductor light emitting diodes including multiple bond pads on a single semiconductor die
A light emitting device includes a single semiconductor die light emitting diode and at least five bond pads on the single semiconductor die. The bond pads may be in the four corners and at least one midpoint of the single semiconductor die. A wavelength conversion layer may be provided and bond pad extensions may extend through the wavelength conversion layer. Multiple wire bond connections may also be provided.
US08524508B2 Methods of treating neuromyelitis optica (NMO)
The present invention provides for methods and materials for diagnosing and treating neuromyelitis optica (NMO).
US08524507B2 Method for detecting a target molecule in a biological sample
A method is provided for detecting a target molecule in a biological sample. One step of the method includes immobilizing the biological sample on a membrane. Next, the membrane-bound biological sample is contacted with at least one detection moiety. The membrane-bound biological sample is then separately mated with a substrate and the target molecule detected. At least one step of the method is performed under positive pressure or a vacuum.
US08524506B2 Methods for sampling a liquid flow
Methods for sampling a liquid flow are provided. The method includes supplying a continuous liquid flow from a continuous flow fluid input source to a surface along a first flow path. The method additionally includes sampling the continuous liquid flow by performing an electric field-based technique to split off a sample droplet from a portion of the liquid flow, whereby the sample droplet is distinct from the liquid flow and controllable independently of the liquid flow, wherein the electric field-based technique is performed by providing a set of electrodes on the surface and selectively biasing the set of electrodes, whereby the sample droplet is formed on one of the set of electrodes.
US08524503B2 Detection using a dye and a dye modifier
The present invention relates to dyes in general. The present invention provides a wide range of dyes and kits containing the same, which are applicable for labeling a variety of biomolecules such as nucleic acids, cells and microorganisms. The present invention also provides various methods of using the dyes for research and development, forensic identification, environmental studies, diagnosis, prognosis, and/or treatment of disease conditions.
US08524500B2 Methods and compositions for targeted cleavage and recombination
Disclosed herein are methods and compositions for targeted cleavage of a genomic sequence, targeted alteration of a genomic sequence, and targeted recombination between a genomic region and an exogenous polynucleotide homologous to the genomic region. The compositions include fusion proteins comprising a cleavage domain (or cleavage half-domain) and an engineered zinc finger domain and polynucleotides encoding same. Methods for targeted cleavage include introduction of such fusion proteins, or polynucleotides encoding same, into a cell. Methods for targeted recombination additionally include introduction of an exogenous polynucleotide homologous to a genomic region into cells comprising the disclosed fusion proteins.
US08524495B2 Methods for inducing the differentiation of blood monocytes into functional dendritic cells
Methods are provided for treating blood monocytes to produce functional antigen presenting dendritic cells. An extracorporeal quantity of a subject's blood is treated to separate the blood into a plasma component containing proteins, a platelet component and a buffy coat component. A plastic treatment device is provided having plastic channels that allow transmittance of light to the interior of the plastic device and a light source that produces light of a wave length selected to activate the photoactivatable agent. The plasma component containing proteins is first pumped through the plastic treatment device, followed by the platelet component and finally the buffy coat component. The resulting treated cells may be incubated or reinfused directly to the subject.
US08524487B2 One-transistor pixel array with cascoded column circuit
To reduce the pixel size to the smallest dimensions and simplest form of operation, a pixel may be formed by using only one ion sensitive field-effect transistor (ISFET). This one-transistor, or 1T, pixel can provide gain by converting the drain current to voltage in the column. Configurable pixels can be created to allow both common source read out as well as source follower read out. A plurality of the 1T pixels may form an array, having a number of rows and a number of columns and a column readout circuit in each column. A cascoded device enabled during readout may be used to provide increased programmable gain.
US08524484B2 Immunogenic minicells and methods of use
The disclosed invention relates to immunogenic minicells cells (anucleated) and their use to induce an immune response from a subject.
US08524479B2 URA5 gene and methods for stable genetic integration in yeast
A novel gene encoding P. pastoris orotate-phosphoribosyl transferase (URA5) is disclosed. Methods for producing and selecting yeast strains capable of stable genetic integration of heterologous sequences into the host genome are also provided.
US08524475B1 Polypeptides having colanic acid-degrading activity
The present disclosure generally relates to polypeptides having colanic acid-degrading activity and methods of using the same. Polynucleotides encoding such polypeptides are also described. The polypeptides may be used, for example, in processes for degrading colanic acid, processes for the removal of endotoxins from biological samples, and processes for purifying plasmid DNA.
US08524467B2 Diagnostic and therapeutic targets for leukemia
The present invention relates to methods of identifying candidate compounds for the treatment of leukemia and diagnostic methods based on histone methylation and HoxA5 promoter activity.
US08524465B2 Agonists of bitter taste receptors and uses thereof
The present invention relates to agonists of the human bitter-taste receptors hTAS2R14, hTAS2R10 and hTAS2R4 and their role in bitter taste transduction. The invention also relates to methods for identifying molecules that modulate, e.g. suppress, or enhance hTAS2R14, hTAS2R10 and hTAS2R4 bitter taste transduction or bitter taste response.
US08524462B2 Methods and compositions for diagnosis and prognosis of renal artery stenosis
The present invention relates to methods and compositions for monitoring, diagnosis, prognosis, and determination of treatment regimens in subjects in the context of renal artery stenosis (RAS). In particular, the invention relates to using assays that detect NGAL, their use to diagnose RAS in subjects suffering from hypertension, and their use in prognosis, particularly of mortality and worsening renal function.
US08524459B2 Method for the in vitro diagnosis of stroke
The present invention relates to a method for the in vitro diagnosis of stroke and transient ischemic attack (TIA) in an individual, comprising the following steps: (a) measuring the level of proBNP(1-108), or of fragments of proBNP(1-108) comprising a RAPRSP sequence (SEQ ID NO: 1), in a biological sample of the individual; (b) comparing the measured level with a cut-off value; (c) determining therefrom whether a stroke or a TIA has occurred in the individual.
US08524458B2 Secretory protein biomarkers for high efficiency protein expression
The instant invention relates to the field of protein production, and in particular is relates to compositions and processes for improving the production levels of recombinant proteins expressed in host cells.
US08524456B2 Recombinant monoclonal antibodies and corresponding antigens for colon and pancreatic cancers
The present invention provides for recombinant monoclonal antibodies that bind to human colorectal and pancreatic carcinoma-associated antigens, along with nucleic acid sequences encoding the antibody chains, and the amino acid sequences corresponding to the nucleic acids, and uses for these antibodies, nucleic acids and amino acids.
US08524454B2 Transcobalamin receptor polypeptides, nucleic acids, and modulators thereof, and related methods of use in modulating cell growth and treating cancer and cobalamin deficiency
The present invention provides the amino acid and polynucleotide sequences of the transcobalamin receptor, as well as modulators of the transcobalamin receptor. Accordingly, the present invention provides compositions and methods for the treatment and prevention of diseases and disorders associated with cobalamin deficiency, including compositions and methods that promote cobalamin uptake. In addition, the present invention provides compositions and methods for the detection, treatment, and prevention of diseases associated with deregulated cell growth, including, e.g., cancer and autoimmune disorders, including compositions and methods that inhibit cobalamin uptake.
US08524449B2 Method for enumeration of mammalian cell micronuclei
The present invention relates a method for the enumeration of mammalian cell micronuclei, while distinguishing micronuclei from the chromatin of dead and dying cells. The method utilizes differential staining of chromatin from dead and dying cells, to distinguish the chromatin from micronuclei and nuclei that can be detected based upon fluorescent emission and light scatter following exposure to an excitatory light source. Counting of micronuclei events relative to the number of nuclei can be used to assess the DNA-damaging potential of a chemical agent, the DNA-damaging potential of a physical agent, the effects of an agent which can modify endogenously-induced DNA damage, and the effects of an agent which can modify exogenously-induced DNA damage. Kits for practicing the invention are also disclosed.
US08524448B2 Method and substances for isolating miRNAs
A capture probe suitable for use with a method for isolating miRNAs. A method for isolating an miRNA of interest from a sample comprising the miRNA of interest comprising providing the capture probe. A method for identifying an miRNA of interest.
US08524447B2 Fluorescently labeled fusion protein for assaying adenosine triphosphate
The object of the present invention is to provide a substance, which is easy to handle and enables the measurement of ATP with a high sensitivity regardless of the concentration of protein, and further a measuring method of ATP using the substance. Such object is solved with a fluorescence labelled fusion protein obtained by attaching two types of fluorescent substances of potential donor and acceptor for fluorescence resonance energy transfer (FRET) respectively to a protein which can cause structural changes depending on ATP binding, namely ε protein, which is the subunit of ATP synthetase, and further solved by contacting the fluorescence labelled fusion protein with a subject substance and then measuring the fluorescence spectra.
US08524442B1 Integrated membrane lamination and UV exposure system and method of the same
A combined laminating and exposing apparatus for exposing a photosensitive printing blank to actinic radiation in a printing plate manufacturing system and a method of using the same are disclosed. The photosensitive printing blank comprises a backing layer, at least one photocurable layer disposed on the backing layer, and a laser ablatable mask layer disposed on the at least one photocurable layer, wherein the laser ablatable mask layer is laser ablated to create an in situ negative in the laser ablatable mask layer. The exposing apparatus comprises: (a) a laminating apparatus for laminating an oxygen barrier layer to a top of the laser ablated mask layer; (b) a conveyor; (c) a first exposing device for imagewise exposing the at least one photocurable layer to actinic radiation, and (d) a second exposing device for exposing the at least one photocurable layer to actinic radiation through the backing layer.
US08524440B2 Photoresist composition
The present invention provides a photoresist composition comprisinga resin which comprises a structural unit represented by the formula (I): wherein Q1 and Q2 independently represent a fluorine atom etc., U represents a C1-C20 divalent hydrocarbon group etc., X1 represents —O—CO— etc., and A+ represents an organic counter ion, and a compound represented by the formula (D′): wherein R51, R52, R53 and R54 independently represent a C1-C20 alkyl group etc., and A11 represents a C1-C36 saturated cyclic hydrocarbon group which may have one or more substituents and which may contain one or more heteroatoms.
US08524439B2 Silsesquioxane resin systems with base additives bearing electron-attracting functionalities
A silsesquioxane-based composition that contains (a) silsesquioxane resins that contain HSiO3/2 units and RSiO3/2 units wherein; R is an acid dissociable group, and (b) 7-diethylamino-4-methylcoumarin. The silsesquioxane-based compositions are useful as positive resist compositions in forming patterned features on substrate, particularly useful for multi-layer layer (i.e. bilayer) 193 nm & 157 nm photolithographic applications.
US08524435B2 Liquid developer and wet-type image forming apparatus
A liquid developer containing an electrically insulating carrier fluid and colored particles dispersed in the carrier fluid and a wet-type image forming apparatus using this liquid developer are provided, with the colored particles being pigments and this liquid developer containing at least one selected from a group consisting of styrene elastomer, polyvinyl butyral, cyclic olefin copolymer and cellulose ether. Additionally, a liquid developer containing an electrically insulating carrier fluid, colored particles dispersed in the carrier fluid, and an organic macromolecular compound for fixing the colored particles to a recording medium and a wet-type image forming apparatus using this liquid developer are provided, with the organic macromolecular compound being dissolved in the carrier fluid and the colored particles being pigments.
US08524429B2 Electrophotographic photosensitive member, process cartridge, and electrophotographic apparatus
The present invention relates to an electrophotographic photosensitive member obtained by providing an intermediate layer and a photosensitive layer on a conductive support in the stated order, the electrophotographic photosensitive member being characterized in that the intermediate layer contains a specific polyolefin resin and a specific organic electron-transporting substance, and a process cartridge and an electrophotographic apparatus each having the electrophotographic photosensitive member.
US08524428B2 Electrophotographic photoreceptor, process cartridge, and image forming apparatus
An electrophotographic photoreceptor includes: a conductive substrate; a photosensitive layer including a charge-generating layer containing a charge-generating material and a charge-transporting layer containing a charge-transporting material, the charge-transporting layer having a hole mobility of about 5.0×10−6 (cm2/V·sec) or less at an electric field of 2 V/cm; and an overcoat layer that is provided on the photosensitive layer and contains a cured material of a charge-transporting material, wherein relational expression (1) Ip(OCL)>Ip(CTL)>Ip(CGL) is satisfied wherein Ip(CGL) represents an ionization potential (eV) of the charge-generating material contained in the charge-generating layer; Ip(CTL) represents an ionization potential (eV) of the charge-transporting material contained in the charge-transporting layer; and Ip(OCL) represents an ionization potential (eV) of the charge-transporting material contained in the overcoat layer.
US08524427B2 Electron beam lithography system and method for improving throughput
An electron beam lithography method and apparatus for improving throughput is disclosed. An exemplary lithography method includes receiving a pattern layout having a pattern layout dimension; shrinking the pattern layout dimension; and overexposing a material layer to the shrunk pattern layout dimension, thereby forming the pattern layout having the pattern layout dimension on the material layer.
US08524425B2 Oxime ester photoinitiators
Compounds of the formula (I) and (II) M1, M2 and M3 independently of one another are no bond, a direct bond, CO, O, S, SO, SO2 or NR14; provided that at least one of M1, M2 or M3 is a direct bond, CO, O, S, SO, SO2 or NR14; M4 is a direct bond, CR″3R″4, CS, O, S, SO, or SO2; Y is S or NR18; R1 for example is hydrogen, C3-C8cycloalkyl, phenyl or napthyl, both of which are optionally substituted; R2 for example is C1-C20alkyl; R″2 has one of the meanings given for R2; R3 and R4 are for example hydrogen, halogen, C1-C20alkyl; R′3, R′4, R″3 and R″4 independently of one another have one of the meanings given for R3 and R4; and R5 is for example hydrogen, halogen, C1-C20alkyl; provided that in the compounds of the formula (I) at least two oxime ester groups are present and provided that at least one specified substituent R2 or R″2 is present; exhibit an unexpectedly good performance in photopolymerization reactions.
US08524418B2 Polymer electrolyte fuel cell
A polymer electrolyte fuel cell includes a power generation part as an electrolyte membrane-electrode assembly formed of a solid polymer electrolyte membrane, a fuel electrode arranged in contact with one side of the solid polymer electrolyte membrane and an oxygen electrode arranged in contact with the other side of the membrane, and a fuel supply part for storing and supplying an alcohol fuel to the fuel electrode. The fuel supply part is composed of a high-concentration fuel tank for storing and supplying a highly-concentrated fuel and a water fuel tank for storing and supplying a water fuel. The fuel is gasified and supplied to the power generation part through a fuel gasification/supply layer provided between at least the high-concentration fuel tank and the fuel electrode.
US08524416B2 Electrolyte electrode assembly and fuel cell
A unit cell of a fuel cell is formed by sandwiching a membrane electrode assembly between a first metal separator and a second metal separator. The membrane electrode assembly includes a solid polymer electrolyte membrane having a reinforcement member on both surfaces of the outer end of the solid polymer electrolyte membrane. Frame members are provided on the reinforcement member outside an anode, and a fuel gas inlet channel and a fuel gas outlet channel are formed by the frame members, at positions corresponding to a fuel gas inlet buffer and a fuel gas outlet buffer.
US08524410B2 Water removal from gas flow channels of fuel cells
An apparatus for water management in a fuel cell. The apparatus includes a fuel cell having a first porous electrode layer, a second porous electrode layer, a proton-conducting membrane positioned between the first electrode and second electrode layers, and a first and second bi-polar distribution plate, wherein the first bi-polar distribution plate is positioned on a top of the first electrode layer and defining a first gas flow channel, and wherein the second bi-polar distribution plate is positioned on a bottom of the second electrode layer and defining a second gas flow channel. The apparatus further includes a mechanism for oscillating liquid water formed in the gas flow channel and configured to remove the liquid water.
US08524406B2 Fuel cell system and start-up control method therefor
An object is to suppress the degradation of durability due to a heat concentration while performing a rapid warm-up operation as necessary, when starting a fuel cell system at temperatures below freezing point. In order to achieve such an object, the present invention stores in a memory an operation termination condition of the last operation of the system, data such as the start-up temperature, or the remaining amount of product water at the time of the last scavenging; calculates the remaining amount of product water based on data read out from the memory at the time of starting the system to make judgments, from the remaining amount and the start-up temperature, on whether or not a rapid warm-up of the system is necessary and whether to start without circulating the cooling water when a rapid warm-up is necessary; and conducts, based on the judgment result provided by the judgment means, with or without circulating the cooling water, a low-efficiency power generation where a reactant gas to be supplied to the fuel cell is less than that in a normal power generation and an electronic power loss is larger than that in a normal power generation. The data includes, for example, an impedance, a temperature of the fuel cell and a scavenging air amount at the last termination of the operation of the fuel cell.
US08524403B2 Water content estimation apparatus for fuel cell and fuel cell system
The water content estimation apparatus for a fuel cell includes an estimating unit for estimating a residual water content distribution in a reactant gas flow channel and a moisture content distribution in an electrolyte membrane in a cell plane of a single cell while taking into consideration water transfer that occurs between an anode electrode and a cathode electrode via the electrolyte membrane between the anode electrode and the cathode electrode. The fuel cell system performs control based on an estimation result by the estimating unit so that the fuel cell assumes a predetermined water condition.
US08524399B2 Non-aqueous electrolyte and secondary battery comprising the same
Disclosed is a non-aqueous electrolyte including an electrolyte salt and an electrolyte solvent, the non-aqueous electrolyte further including a compound containing both a carboxy group and a (meth)acrylic group, and a secondary battery including the non-aqueous electrolyte. The use of the compound containing both the carboxy group and the (meth)acrylic group as a component for an electrolyte significantly reduces the increase of battery thickness at high temperature storage.
US08524398B2 All-electron battery having area-enhanced electrodes
Improved energy storage is provided by exploiting two physical effects in combination. The first effect can be referred to as the All-Electron Battery (AEB) effect, and relates to the use of inclusions embedded in a dielectric structure between two electrodes of a capacitor. Electrons can tunnel through the dielectric between the electrodes and the inclusions, thereby increasing the charge storage density relative to a conventional capacitor. The second effect can be referred to as an area enhancement effect, and relates to the use of micro-structuring or nano-structuring on one or both of the electrodes to provide an enhanced interface area relative to the electrode geometrical area. Area enhancement is advantageous for reducing the self-discharge rate of the device.
US08524397B1 Battery having high rate and high capacity capabilities
The battery has an electrolyte activating one or more anodes and one or more cathodes. At least one of the one or more cathodes includes or consists of one or more first active materials selected from the group consisting of: fluorinated carbon (CFx),CuCl2, and LiCuCl2; and includes or consists of one or more second active materials selected from the group consisting of lithium vanadium oxide, such as Li1+yV3O8, where y is greater than zero and/or less than 0.3, TiS2, polypyrrole, MoO2, MoS2, MnO2, V2O5, V6O13, H2V3O8, and metal vanadium oxides represented by MyH1−yV3O8 where 0
US08524393B2 Method for producing electrode laminate and electrode laminate
A method for producing an electrode laminate including a current collector using aluminum as the material and an electrode layer laminated on the current collector, where the method includes the steps of: laminating an electrode layer forming composition, which contains at least a sulfide-based solid electrolyte and an active material and no binding agent, on the current collector; and f heating the current collector and the electrode layer forming composition at a temperature of not less than 60° C. and adhering them.
US08524392B2 Pouch-type rechargeable battery and its method of manufacture
A pouch-type rechargeable battery and its method of manufacture includes: an electrode assembly having a resin layer attached to the outer surface of an electrode tab, and a pouch having a sealing part formed on the ends of the top and bottom thereof, housing the electrode assembly. The resin layer is positioned inside the sealing part and sealed by heat and pressure for preventing it from being exposed outside the sealing part. Thus, the pouch-type rechargeable battery is adapted to seal the resin layer in the sealing part, instead of exposing it outside the sealing part so as to reduce the longitudinal length of the battery, thereby improving the capacity of the battery.
US08524390B2 Secondary battery
A secondary battery including an electrode assembly; a case housing the electrode assembly; a current collecting terminal electrically connected to the electrode assembly; a cap plate capping the case to seal the electrode assembly, the case, and the current collecting terminal; an insulation member interposed between the current collecting terminal and the cap plate; an electrode terminal electrically connected to the current collecting terminal and extending through the insulation member and the cap plate; and shock damping members between the electrode assembly and the cap plate, the shock damping members being coupled with the insulation member.
US08524384B2 Rechargeable battery
A rechargeable battery including an electrode assembly, the electrode assembly including a positive electrode and a negative electrode; a case accommodating the electrode assembly; a cap plate coupled with the case; and a vent member welded to the cap plate, the vent member including a notch thereon, wherein a welded unit, by which the vent member and the cap plate are welded together, is separately formed toward a center of the cap plate in a thickness direction from an outer side of the cap plate so as to be spaced apart from the outer side of the cap plate.
US08524383B2 Power generating system and control method for the same
A power generating system includes: a plurality of cells forming a fuel cell battery for generating power; a cell temperature measuring unit provided for each cell; a thermoelectric converter provided for each cell; a heating unit which heats the plurality of cells; a first control unit which controls the heating unit; and a second control unit, provided for each thermoelectric converter, for controlling the thermoelectric converter, wherein the first control unit controls the heating unit so as to bring the temperature of the heating unit to within a predetermined control temperature range, and the second control unit performs control so that if the temperature of the cell lies outside a predetermined operating temperature range, the thermoelectric converter is switched to the thermal transfer mode and is controlled so as to bring the temperature of the cell to within the predetermined operating temperature range, and if the temperature of the cell lies within the predetermined operating temperature range, the thermoelectric converter is switched to the power generation mode.
US08524376B2 Heat-resistant Sn-plated Cu-Zn alloy strip with suppressed whiskering
In an Sn-plated strip in which a copper alloy containing 15 to 40 mass % of Zn in terms of an average concentration is used as an alloy strip and the layers of an Sn phase, an Sn—Cu alloy phase and an Ni phase constitute a plating film from the surface to the alloy strip, the Zn concentration of the surface of the Sn phase is adjusted to a range of 0.1 to 5.0 mass %. The alloy may further contain 0.005 to 3.0 mass % in total of an arbitrary constituent selected from Sn, Ag, Pb, Fe, Ni, Mn, Si, Al and Ti. Moreover, the alloy may be a copper base alloy containing 15 to 40 mass % of Zn, 8 to 20 mass % of Ni, 0 to 0.5 mass % of Mn and a balance of Cu and unavoidable impurities, and may further contain 0.005 to 10 mass % in total of the above arbitrary constituent. There is provided a Cu/Ni double layer base reflowed Sn-plated Cu—Zn alloy strip in which generation of whiskers is suppressed.
US08524372B2 Waterproof plasma treated footwear with liquid absorbing footbed
An item of footwear having a liquid-repelling polymeric coating, obtained by a plasma treatment process, provided over at least part of a surface thereof, said item also being provided at the region on the inside upon which the wearer's foot rests with a liquid-absorbing foot supporting footbed. Items of this type provide improved comfort for the wearer.
US08524370B2 Multilayer films including thermoplastic silicone block copolymers
A multilayer film includes a first layer of a first polymeric material and a second layer of a second polymeric material. The first material has a first index of refraction and the second material has a second index of refraction less than the first index of refraction. In one embodiment, the second material includes a polydiorganosiloxane polyamide block copolymer. In another embodiment, the second material includes a polydiorganosiloxane polyoxamide block copolymer.
US08524368B2 Charge-dynamic polymers and delivery of anionic compounds
The present invention provides dynamic charge state cationic polymers that are useful for delivery of anionic molecules. The dynamic charge state cationic polymers are designed to have cationic charge densities that decrease by removal of removable functional groups from the polymers. The present invention also provides interpolyelectrolyte complexes containing the polymers complexed to a polyanion. Methods for using the interpolyelectrolyte complexes to deliver anionic compounds are also provided.
US08524366B2 Graphene wafer, method for manufacturing the graphene wafer, method for releasing a graphene layer, and method for manufacturing a graphene device
A method is used for releasing a graphene layer from a substrate. A graphene layer is first formed on a surface of a first substrate. A metal layer is then formed on a surface of the graphene layer. A pulling force is then applied to the metal layer to detach the graphene layer from the first substrate. The released graphene layer is bonded by intermolecular force onto a surface of a second substrate separate from the first substrate or onto a surface of a bonding layer formed on the surface of the second substrate. The metal layer is then removed, by for example, etching.
US08524364B2 Two-dimensional composite particle adapted for use as a catalyst and method of making same
The present invention is directed to a composite particle that is microscopically two-dimensional with a third nanoscopic dimension, and to methods of making same. The particle may include a support and a metal layer. The metal layer may be catalytically active such that the particle is adapted to act as a catalyst.
US08524356B1 Bonded patch having multiple zones of fracture toughness
A composite laminate patch for reworking an inconsistent area in a structure has inner and outer control regions possessing differing interlaminar fracture toughnesses for controlling the advance of a disbond in the patch. One or more separation zones in the patch between the control regions aids in diffusing the fracture energy of the disbond as the disband advances from the inner region to the outer region.
US08524355B2 Disposable absorbent article
A disposable absorbent article includes an absorbent mat provided between a liquid-permeable top sheet and a liquid-impermeable back sheet. Herein, the absorbent mat includes a sheet-like water-absorbent layer that contains a water-absorbent resin powder but that does not contain pulp fibers, and a fiber assembly layer that contains both the water-absorbent resin powder and the pulp fibers, the sheet-like water-absorbent layer and the fiber assembly layer arranged sequentially in this order from a top sheet side. The fiber assembly layer includes a fiber presence region in which both the pulp fibers and the water-absorbent resin powder are present, and a fiber absence region in which both the pulp fibers and the water-absorbent resin powder are absent, the fiber presence region and the fiber absence region formed to be adjacent with each other.
US08524354B2 Acrylated natural oil compositions
The present invention relates to a radiation curable composition comprising (a) from 1 to 99% by weight of a (meth)acrylated natural oil which is the reaction product of an unsaturated natural oil with an unsaturated anhydride and a hydroxyl functional (meth)acrylate, and (b) from 1 to 99% by weight of a (meth)acrylated oligomer and/or monomer, and optionally an inert resin and/or filler, as well as their use for making inks and coatings.
US08524353B2 Structural component
Structural components are traditionally made by rolling or extruding to define a desired shape. Such processes lead to extra costs and inflexibility with regard to custom design. By providing a structural component comprising plates having edges extending regularly in a cruciform appropriate structural components can be provided. The plates are secured together through lock tabs passing through lock apertures and twisted into locking engagement. Either side of the locking tabs respective orientation tabs are provided to engage orientation apertures to facilitate local stability in the plates for robust locking location. Components can be formed from sheet materials and the outer profile of the components specifically shaped for particular requirements.
US08524348B1 Stacked film optical data storage device and method of manufacture
A data storage device includes a substrate layer, made of a moldable non-photopolymer plastic substrate and having a servo layer, adjoined to a stacked film structure that is constructed of multiple functional films, having data layers, with spacer film(s) disposed between each of the functional films. Methods of manufacturing the data storage device include using a roll-to-roll system to adhere thin spacer film extrusions between the multiple functional film extrusions so as to construct the stacked film structure. An additional method uses an application of functional film coating to thin spacer films and a roll-to-roll system.
US08524342B2 Plastic composite moulded bodies obtainable by welding in an electromagnetic alternating field
The invention relates to plastics composite moldings obtainable via welding in an alternating electromagnetic field, in which the weld is obtained with the aid of a plastics material which comprises nano-scale, magnetic oxidic particles, which are composed of aggregated primary particles, and where the primary particles are composed of magnetic metal oxide domains whose diameter is from 2 to 100 nm in a non-magnetic metal oxide matrix or non-magnetic metalloid oxide matrix.
US08524337B2 Heat treated coated article having glass substrate(s) and indium-tin-oxide (ITO) inclusive coating
Certain example embodiments of this invention relate to articles including anticondensation and/or low-E coatings that are exposed to an external environment, and/or methods of making the same. In certain example embodiments, the anticondensation and/or low-E coatings may be survivable in an outside environment. The coatings also may have a sufficiently low sheet resistance and hemispherical emissivity such that the glass surface is more likely to retain heat from the interior area, thereby reducing (and sometimes completely eliminating) the presence condensation thereon. The articles of certain example embodiments may be, for example, skylights, vehicle windows or windshields, IG units, VIG units, refrigerator/freezer doors, and/or the like.
US08524336B2 Recording medium
The invention provides a recording medium having excellent ink absorbency and capable of forming a sharp image thereon. The recording medium has a substrate, and a first layer and an outermost layer provided on the substrate in this order, wherein the first layer contains at least one of alumina and alumina hydrate, the outermost layer contains a pigment and is lower in refractive index than the first layer, and the absolute dry coating amount of the outermost layer is 0.1 g/m2 or more and 0.5 g/m2 or less.
US08524335B2 Method for stiffening synthetic ribbons of a synthetic turf surface
The present invention is directed to a system and method for adjusting the relative stiffness of a synthetic turf system's synthetic ribbons. A stiffening agent is applied to the synthetic turf system such that its synthetic ribbons that are responsive to the stiffening agent will stiffen subsequent to the application of the stiffening agent.
US08524330B2 Method and apparatus for paint curing
A method for curing a paint coating applied to a workpiece includes applying radiant light energy to cure the paint coating on surfaces of the workpiece within a line of sight of a radiant light energy source, and applying ambient air to the workpiece to cure the paint coating on surfaces of the workpiece not within the line of sight of the radiant light energy source.
US08524328B2 Methods for manufacturing organic EL display panel and organic EL display device
Provided is an organic EL display panel offering improved luminance without increasing the current density of current flowing through organic light-emitting layers, comprising: substrate; TFT layer formed on substrate; planarizing film formed above TFT layer and having contact holes; lower electrodes arranged above planarizing film in a matrix in one-to-one correspondence with pixel units, and brought into conduction with TFT layer via contact holes; grid-shaped bank formed above planarizing film and defining openings corresponding one-to-one to lower electrodes; organic light-emitting layers formed in openings; and upper electrode formed above light-emitting layers. Each contact hole is positioned between a pair of openings adjacent in the column direction. At least one of opposing sides of any pair of openings adjacent in the column direction is reduced in width in the row direction and extends in the column direction so as to be adjacent in the row direction to the corresponding contact hole.
US08524327B2 Liquid adhesive dispensing system
A liquid adhesive dispensing system operable for more uniformly applying liquid adhesive foam onto moving substrates, notwithstanding changes in line speed, adhesive liquid flow rates, or foaming/atomizing air pressures. The illustrated liquid adhesive system includes a header having a plurality of air atomizing spray guns; the spray guns each having a respective variable speed positive displacement pump for directing a metered quantity of liquid adhesive from a liquid adhesive supply to the respective spray gun; and a control for controlling the operating speed of the positive displacement pumps in relation to the speed of the moving substrate and the foaming/atomizing air pressure to the spray guns in relation to the operating speed of the positive displacement pumps. The control further is operable for monitoring pressures across the positive displacement pumps for insuring the accurate direction of metered quantities of liquid to the spray guns. The spray guns are adapted for enhanced liquid adhesive foaming and atomization, and the header is convertible into a closed housing structure effective for containing cleaning and purge liquids during an automatically operable cleaning cycle of operation.
US08524324B2 Complex oxide film and method for producing same, dielectric material including complex oxide film, piezoelectric material, capacitor, piezoelectric element, and electronic device
The invention relates to a method for a complex oxide film having a high relative dielectric constant formed on a substrate surface by wet-treatment method and a production process of the complex oxide film comprising a step of washing the complex oxide film with an acid solution of pH 5 or less to thereby reduce salts in the film. Further, the invention relates to a dielectric material and a piezoelectric material containing the complex oxide film, a capacitor and a piezoelectric element including the material, and a electronic device comprising the element.
US08524320B1 Process for coating the interior surface of water service lines
Methods, processes, compositions and systems for preventing leaching effects from drinking water service pipes (such as lead, steel and copper) having an inner diameter of at least approximately 12 mm and the pipe coatings. 2-step thermoset resin coating is applied to pipe interiors and inner surfaces of fittings/valves, and exterior ends of the pipes that fit within the fittings/valves “in place” without dismantling the pipes from fittings where the curing agent can be phenol free and plasticizer free adduct. The coating can reduce heavy metals, such as lead, from leaching from installed pipes and fittings to less than approximately 10 μg/L (10 ppb). When cured, specific leachates, Bisphenol A and Epichlorohydrin from the coatings will be (less than) <1 μg/L (1 ppb) with overall TOC levels measured at (less than) <2.5 mg/L (2.5 ppm). Pipes can be returned to service from at least approximately 1 to approximately 2 hours.
US08524312B2 Applicator for spraying elastomeric materials
An applicator for spraying an elastomeric material comprises an applicator body having an internal bore and a fluid inlet for receiving a supply of the elastomeric material. A nozzle is coupled to the applicator body and has a discharge end with a spray outlet in fluid communication with the fluid inlet via a fluid passageway. A needle valve is slidably mounted within the internal bore for movement between a closed position for closing the fluid passageway, and an open position for opening the fluid passageway so as to spray the elastomeric material. An air cap is coupled to the applicator body adjacent the nozzle for providing an atomizing airflow and a fan control airflow. The needle valve has a tip portion shaped to extend through the nozzle so as to be substantially flush with the discharge end of the nozzle when the needle valve is in the closed position.
US08524311B1 Method of manufacturing a flexible circuit electrode array
Polymer materials make useful materials as electrode array bodies for neural stimulation. They are particularly useful for retinal stimulation to create artificial vision. Regardless of which polymer is used, the basic construction method is the same. A layer of polymer is laid down. A layer of metal is applied to the polymer and patterned to create electrodes and leads for those electrodes. A second layer of polymer is applied over the metal layer and patterned to leave openings for the electrodes, or openings are created later by means such as laser ablation. Hence the array and its supply cable are formed of a single body. A method for manufacturing a flexible circuit electrode array, comprises: a) depositing a metal trace layer on an insulator polymer base layer; b) applying a layer of photoresist on said metal trace layer and patterning said metal trace layer and forming metal traces on said insulator polymer base layer; and c) activating said insulator polymer base layer and depositing a top insulator polymer layer and forming one single insulating polymer layer with said base insulator polymer layer; wherein the insulator polymer layers were treated at a temperature from 80-150° C. and then at a temperature from 230-350° C.
US08524308B2 Processed tea leaf product obtained by extrusion
The present invention provides a technique for producing a tea wherein water-insoluble components of tea leaves have been made soluble in water and the natural umami components inherent to tea leaves have been increased. It also provides a technique for manufacturing a tea-based alcoholic drink which has “tea leaf-origin aroma”, “umami and body” and “mild alcoholic aftertaste” in a good balance. Tea leaves are processed with an extruder at a temperature of 80 to 150° C. and under a pressure of 0.2 to 30 MPa for 5 to 600 sec while supplying 1 to 100 parts by weight, per 100 parts by weight of the tea leaves, of water or an aqueous sugar solution, Thus, a processed tea leaf product is stably produced while avoiding blowout from the outlet. A tea extracted from this processed tea leaf product shows a significantly improved taste.
US08524301B2 Crumb coating for food products
A method of manufacture of a crumb coated food product comprising the steps offorming an aqueous mixture comprising: a flour mixture comprising one or more flours, sodium bicarbonate, optional additives selected from processing aids, salts, colorants and, water; adding the mixture into an extruder; adding an aqueous gelling agent to the extruder; extruding the resultant mixture at a temperature greater than 100° C. to form an extrudate; allowing the extrudate to expand to form a porous product; drying the product, and milling the dried product to form a crumb.
US08524299B2 Wet pet food products comprising a first layer bonded with a base food
The wet pet food product of the present invention has more appeal to a consumer and ease of access for a pet. The wet pet food product contains a base food; a first layer; optionally a coating associated with said base food; and wherein said first layer is bonded with the base food.
US08524298B2 Process and device for enriching water with magnesium ions
The invention relates to a process and a device for enriching water, in particular drinking water, with magnesium ions. In order to enable enrichment of water with magnesium ions in exchange for calcium ions and/or heavy metal ions during treatment of water, and in particular of drinking water, it is proposed according to the invention to pass the water through an ion exchanger which contains a weakly acidic ion exchange material, wherein at least a part of its ion exchange capacity is loaded with magnesium ions.
US08524297B2 Increased folate production levels in Lactobacillus fermenting melon juice
The invention relates to the field of food, feed and food supplements comprising high folate levels, whereby the folate is produced by fermentation of Lactobacillus strains on melon fruit extract. Methods for increasing folate production of Lactobacillus strains are also provided.
US08524294B2 Pressed agglomerates suitable for consumption having retarded aroma release
A pressed agglomerate (compacted material) which is suitable for consumption, a process for its preparation, its use for aromatizing products and products comprising such a pressed agglomerate are described.
US08524289B2 Process for producing carotenoid
The present invention provides a method for producing a carotenoid-containing composition, comprising the steps of: subjecting a culture of a carotenoid-producing microorganism to an extraction treatment using a water-soluble organic solvent; dispersing the resulting extract solution in water for micellization; heat stirring the resulting micellized solution in a solvent break the micelles and precipitate the carotenoid component of interest to obtain the precipitate; collecting and heat washing the precipitate with ethanol; and further subjecting the precipitate to pulverization/drying; and food, a pharmaceutical composition and a cosmetic product comprising the carotenoid-containing composition.
US08524287B2 Composition for the prevention and treatment of postmenopausal syndrome containing extracts or fractions of Aceriphyllum rossii as an effective ingredient
The present invention relates to a method for the prevention and treatment of postmenopausal syndrome containing the step of administering a pharmaceutically effective dose of the Aceriphyllum rossii or its fractions to a subject. The present inventors confirmed that the Aceriphyllum rossii extract or its fractions of the invention prepared by using water, alcohol or a mixed solvent thereof could promote the expression of the promoter containing estrogen responsive element (ERE) and accelerated the growth of MCF-7, the human breast tissue originated cell line, suggesting that they had estrogen activity. The inventors further confirmed that the extract or its fractions of the invention had the effect of promoting osteocyte differentiation, so that they could be effectively used for the prevention and treatment of postmenopausal syndrome such as hot flush, osteoporosis and phlebothrombosis caused by estrogen deficiency.
US08524284B2 Dispersion having an insecticidal action
Dispersion containing, in addition to water, 0.5 to 20 wt. % of hydrophobic silica, 0.01 to 10 wt. % of a gelling or viscosity-increasing additive, 0.1 to 1 wt. % of a preservative and 0 to 1 wt. % of a surface-active substance. It is prepared by a procedure in which the individual components are dispersed successively or together into the water and in this procedure the individual components are deaerated before and/or during the addition or the dispersion is deaerated during the individual dispersing steps. The dispersion can be employed as an insecticide.
US08524283B2 T cell immunomodulation by placenta cell preparations
A Method for obtaining amniotic mesenchymal tissue cells (AMTC) and/or chorionic mesenchymal tissue cells (CMTC) comprises a) isolating amniotic membrane and/or chorionic membrane from human placenta and/or separating amniotic and chorionic membrane, a) washing the membrane of step a) to remove contaminants b) cutting the membrane of step b) c) incubating the membrane fragments of step c) in a medium containing dispase for 5 to 15 minutes at 33 to 42° C. d) incubating the composition of step d) in a resting solution for 5 to 15 minute at room temperature e) repeating steps d) and e) 0 to 6 times f) if chorionic membrane is involved peeling the stromal layer from the trophoblastic layer of the chorionic membrane of step e or f) g) digesting the fragments obtained in step e), f), or g) respectively, with collagenase for 1 to 5 hours at 33 to 42° C. h) collecting AMTCs and/or CMTCs from the suspension obtained in step h).
US08524279B2 Spray drying methods and related compositions
A method and apparatus are provided for atomizing a liquid under dispersal conditions suitable for spray drying at a commercial plant scale. In one embodiment, a liquid atomizer has a structural body adapted for connection with a spray dryer and a plurality of atomizing nozzles. Each of the atomizing nozzles includes a liquid nozzle adapted to disperse a supply of liquid and a gas nozzle adapted to disperse a supply of gas. In another embodiment, a process for producing a powder blend of at least two target substances in a single processing step is provided.
US08524278B2 Controlled release pharmaceutical formulations of nitazoxanide
Solid dosage formulations of nitazoxanide or a nitazoxanide analogue are provided that comprise a controlled release portion and an immediate release portion. The pharmaceutical composition is typically in the form of a bilayer solid oral dosage form comprising (a) a first layer comprising a first quantity of nitazoxanide or analogue thereof in a controlled release formulation; and (b) a second layer comprising a second quantity of nitazoxanide or analogue thereof in an immediate release formulation. Method of using the formulations in the treatment of hepatitis C are also provided.
US08524274B2 Liposomal composition comprising an active ingredient for relaxing smooth muscle, the production of this composition and the therapeutic use thereof
The invention relates to a pharmaceutical composition made from an active ingredient included in liposomes for topical application, whereby the liposomes have an aqueous medium in the interior thereof and contain at least one active ingredient therein which exerts a direct or indirect relaxing effect on smooth musculature and is preferably selected from the group of prostaglandins, adenylate cyclases, cAMP, AMP, ATP, NO-synthetases, nitrogen monoxide (NO), NO compounds, nitrates, guanylate cyclases, cGMP, GMP, GTP and phosphodiesterases, in particular, Sildenafil. The invention further relates to a method for production of said composition, optionally, in sterile form and the use of the liposomes supporting the active ingredient in various galenic forms for external application in the genital region, for prophylaxis and/or therapy of sexual disorders in men or women and/or for increase of sexual sensitivity.
US08524271B2 Skin wound dressing and preparing method thereof
A skin wound dressing is disclosed. The skin wound dressing comprises Tremella polysaccharide and alginate and is used to cover on a skin wound to accelerate wound healing. The Tremella polysaccharide is isolated from a hot water extract of Tremella fuciformis. The skin wound dressing is a Tremella polysaccharide composite fiber, a Tremella polysaccharide sponge or a Tremella polysaccharide hydrogel.
US08524269B2 Oral compositions comprising edible oils and vitamins and/or minerals and methods for making oral compositions
The present invention provides oral dosage compositions, and methods of making thereof, which contain an edible oil, preferably containing an omega-3 fatty acid, and admixed therein one or more water soluble vitamins and/or minerals, for example vitamins B6, B9, and/or B12. The present invention also provides a method of making the composition comprising mixing the edible oil and one or more water-soluble vitamins and/or minerals to form a suspension or emulsion of the water-soluble vitamins and/or minerals in the edible oil. The mixture can be inserted into capsules, gelcaps, or caplets for oral consumption. An additional aspect of the invention is that the edible oil can coat particles of the water-soluble vitamins and/or minerals, which may preferably provide the vitamins and/or minerals improved absorption in the body due to increased resistance to degradation in the acidic environment of the stomach.
US08524267B2 Dexamethasone formulations in a biodegradable material
Effective treatments of acute pain for extended periods of time are provided. Through the administration of an effective amount of dexamethasone at or near a target site, one can relieve pain cause by diverse sources, including but not limited to spinal disc herniation (i.e. sciatica), spondilothesis, stenosis, discongenic back pain and joint pain as well as pain that is incidental to surgery. When appropriate formulations are provided within biodegradable polymers, this relief can be continued for at least twenty-five days. In some embodiments, the relief can be for at least fifty days, at least one hundred days, at least one hundred and thirty-five days or at least one hundred and eighty days.
US08524265B2 Medical implant sheets useful for tissue regeneration
Described is a medical device in the form of a thin sheet having granules of a calcium-containing, osteoconductive material interconnected by a thin web of polymeric material. The device includes a first face and a second face, wherein at least the first face is populated with proturbances presenting exposed regions of the calcium-containing, osteoconductive material provided by underlying granules. Methods of making and using such devices are also described, as are methods and devices involving the use of very thin polymeric sheets conformed to bone-ingrowth surfaces of load-bearing orthopedic implants.
US08524264B2 Protein stabilized antimicrobial composition formed by melt processing
A method for forming an antimicrobial composition that includes mixing an antimicrobially active botanical oil (e.g., thymol, carvacrol, etc.) and protein within a melt blending device (e.g., extruder) is provided. Despite the problems normally associated with melt processing proteins, the present inventors have discovered that the processing conditions and components may be selectively controlled to allow for the formation of a stable, melt-processed composition that is able to exhibit good mechanical properties. For example, the extrusion temperature(s) and shear rate employed during melt blending are relatively low to help limit polypeptide dissociation, thereby minimizing the impact of aggregation and embrittlement. While the use of such low temperature/shear conditions often tend to reduce mixing efficiency, the present inventors have discovered that a carrier fluid may be employed to enhance the ability of the botanical oil to flow into the internal structure of the protein where it can be retained in a stable manner. The composition is also typically anhydrous and generally free of solvents. In this manner, the protein will not generally disperse before use and prematurely release the botanical oil.
US08524263B2 Sheet-like cosmetic
The present invention is a sheet-like cosmetic produced by impregnating a non-woven fabric with a cosmetic comprising (A) 4-methoxysalicylic acid or a salt thereof and (B) a water soluble polysaccharide. It also provides a sheet-like cosmetic that additionally comprises (C) an oil component, (D) an alkyl-modified carboxyvinyl polymer, (E) a water soluble polymer other than said (B) and (D), and (F) hydroxylamine or a derivative thereof.The object of the present invention is to improve the texture upon use, such as the stickiness and the friction, of a sheet-like cosmetic produced by impregnating a non-woven fabric with a cosmetic comprising 4-methoxysalicylic acid or a salt thereof.
US08524261B2 Pigments
The present invention relates to inorganic spherical pigments which are based on spherical particles having a particle diameter of 0.1-100 μm and are coated on the surface with agglomerates selected from the group ZrO2, ZnO, Al2O3, TiO2, Fe2O3, Fe3O4, FeOOH and BaSO4 or mixtures thereof, and are optionally coated with a further layer (2nd layer) comprising a metal oxide, lake or Berlin Blue, and to the use thereof in paints, coatings, printing inks, security printing inks, plastics, ceramic materials, glasses, in cosmetic formulations, as tracer, as filler and for the preparation of pigment preparations and dry preparations.
US08524259B2 Systems and methods for delivery of materials
Systems and methods for delivering release materials, for example drugs and other bioactive materials. Crystalline polymeric systems, referred to as CYC carriers, are associated with the release materials, through chemical bonding or through physical association. The crystallinity of the CYC carriers results from the presence of crystallizable side chains, for example long chain n-alkyl moieties, which results in relatively low and sharp melting temperatures. One class of CYC carriers, referred to as CYSC polymers, have a majority of the crystallizable side chains pendant from the polymer backbone. Another class of CYC carriers referred to as ECC polymers, have a majority of the crystallizable side chains attached to terminal units of the polymer backbone. The ECC polymers can for example be obtained by modification of PLGA polymers. The CYC carriers in another class of non-polymeric. Some CYC carriers, referred to as CYC assemblies, have enhanced crystallinity as a result of the physical association of crystallizable moieties which are present in different types of molecule, for example between a polymer containing crystallizable moieties and a monomer containing crystallizable moieties. For some uses, particularly the delivery of drugs, a bioerodable CYC carrier is preferably used.
US08524257B2 Menthol-containing solids composition
A menthol-containing solids composition comprising or consisting of (a) a solid menthol component consisting of bodies having a content of 95 wt. % or more menthol, based on the total weight of the bodies, and (b) a solid silicon dioxide component comprising or consisting of particles having a particle size of not more than 100 μm, wherein particles of the silicon dioxide component adhere to the surface of the bodies of the menthol component and wherein the amount of the silicon dioxide component is not more than 4 wt. % and the amount of the menthol component is at least 95 wt. %, in each case based on the total weight of the solids composition.
US08524256B2 Deodorant cosmetic composition comprising at least one semicrystalline polymer
The disclosure relates to a deodorant composition comprising a physiologically acceptable water-in-oil emulsion carrier comprising at least one antiperspirant ingredient and at least one semicrystalline polymer having a melting point greater than or equal to 30° C.The disclosure further relates to the use of cosmetic products for topical application to humans, such as deodorant products, and to methods of treating human perspiration and body odors associated with human perspiration.This composition may be in the form of a cosmetic cream having a very pleasant texture on application to the skin.
US08524255B2 Lingual vestibular dosage-form and delivery system for transmucosal administration of pharmaceutical agents
A pharmaceutical delivery system enabling the oral transmucosal administration of active pharmaceutical agents in a situation where rapid transmucosal administration is preferred to prevent the delay and decomposition of the agents in passing through the intestinal tract. The delivery system comprises a supportive substrate with bilateral lingual vestibular flanges connected at the anterior midline to form a ‘U’ like shape for fitting in the potential space of the bilateral lingual vestibules, and further comprising a handle or tab for holding the device in the mouth of a patient with altered consciousness to prevent aspiration or premature swallowing. The pharmaceutical dosage-form is formulated and shaped to contact the mucosal tissues and may include mucoadhesive compounds, retentive compounds, and/or additional payload enhancers, such as permeation enhancers and flavor enhancers.
US08524250B2 Carrier
The present invention is directed to providing a carrier which can transport a compound to a gut-associated lymphoid tissue efficiently without being degraded or digested. For that purpose, the carrier contains a coccoid cell of a gastric mucosa-damaging spiral bacterium. Preferably, the carrier is orally administered. By making this carrier carry an antigen and orally administering it, a local or a systemic immunological reaction to the antigen can be induced.
US08524247B2 Rabies virus-based recombinant immunocontraceptive compositions and methods of use
Described herein are recombinant rabies viruses comprising a heterologous nucleic acid sequence encoding an immunocontraceptive protein, such as gonadotropin-releasing hormone (GnRH) or zona pellucida 3 (ZP3). The recombinant rabies viruses disclosed herein are recovered by reverse genetics, replicate efficiently, elicit rabies virus neutralizing antibodies and immunocontraceptive peptide-specific antibodies in vaccinated animals, and protect vaccinated animals against wild-type rabies virus challenge. Further provided is a method of immunizing a non-human animal against rabies virus infection and simultaneously inhibiting fertility of the animal, comprising administering an immunogenic composition comprising one or more of the recombinant rabies viruses described herein.
US08524246B2 Treatment of immune disease by mucosal delivery of antigents using genetically modified Lactobacillus
The present invention relates to the treatment of autoimmune and allergic diseases by mucosal delivery by micro-organism, in particular Lactococcus lactis, of secreted immunodominant antigens.
US08524244B2 Targeted therapeutics based on engineered proteins that bind EGFR
The present invention relates to single domain proteins that bind to epidermal growth factor receptor (EGFR). The invention also relates to single domain proteins for use in diagnostic, research and therapeutic applications. The invention further relates to cells comprising such proteins, polynucleotide encoding such proteins or fragments thereof, and to vectors comprising the polynucleotides encoding the innovative proteins.
US08524243B2 Avirulent Salmonella gallinarum variants and pharmaceutical composition using the same
The present invention relates to avirulent Salmonella Gallinarum variants by inactivating virulence gene clusters of Salmonella Gallinarum (SG), a main pathogen of avian salmonellosis, and various uses thereof notably in the production of Salmonella-specific lytic bacteriophages, pharmaceutical compositions and feed additives.
US08524241B2 Fusion proteins comprising a fragment of Vibrio cholerae exotoxin A
The invention features recombinant exotoxins from Vibrio cholerae are for the therapeutic treatment of a variety of human diseases, particularly diseases characterized by an abundance or excess of undesired cells.
US08524240B2 Diagnosis and therapy of hematological malignancies
The present invention relates to the field of diagnosis and therapy of hematological malignancies based on the tumor antigen FMR1NB (also called NY-SAR-35, Cancer/testis antigen 37 or Fragile X mental retardation 1 neighbor protein) and agents specifically targeting this antigen or cells expressing the same, e.g., antibodies. The inventors were able to prove that the molecule is expressed on the cell surface and thus represents a particularly advantageous target in cancer therapy and vaccination. Surprisingly, FMR1NB was found to be associated with hematological malignancies, e.g. acute myeloid leukemia (AML) or chronic myeloid leukemia (CML).
US08524238B2 Cancer targets and uses thereof
Methods and compositions are provided for assessing, treating, and preventing diseases, especially cancer, using cancer-associated targets (“CAT”). Methods and compositions are also provided for determining or predicting the effectiveness of a treatment for these diseases or for selecting a treatment, using CAT. Methods and compositions are further provided for modulating cell function using CAT. Also provided are compositions that modulate CAT (e.g., antagonists or agonists), such as antibodies, proteins, small molecule compounds, and nucleic acid agents (e.g., RNAi and antisense agents), as well as pharmaceutical compositions thereof. Further provided are methods of screening for agents that modulate CAT, and agents identified by these screening methods.
US08524236B2 Methods of antagonizing the binding of CD40 to CD40L with CD40L-specific monovalent polypeptides in autoimmune individuals
The invention relates to antibody polypeptides that monovalently bind CD40L. Antibody polypeptides that are monovalent for binding of CD40L can inhibit CD40L activity while avoiding potential undesirable effects that can occur with antibodies capable of divalent or multivalent binding of CD40L. In one aspect, a monovalent anti-CD40L antibody polypeptide consists of or comprises a single immunoglobulin variable domain that specifically binds and antagonizes the activity of CD40L, preferably without substantially agonizing CD40 and/or CD40L activity. In another aspect, the monovalent anti-CD40L antibody polypeptide is a human antibody polypeptide. The invention further encompasses methods of antagonizing CD40/CD40L interactions in an individual and methods of treating diseases or disorders involving CD40/CD40L interactions, the methods involving administering a monovalent anti-CD40L antibody polypeptide to the individual.
US08524234B2 Antibody for selective inhibition of T-cell responses
The present invention provides compositions, methods, and assays for treating an inflammatory and/or autoimmune disease, and/or transplanted tissue rejection using anti-αβ TCR antibodies and antibody fragments. Anti-αβ TCR antibodies are antibodies which bind to a αβ TCR. Anti-αβ TCR antibodies produced by the hybridoma TOL101 MCB are also provided. Methods for treatment of an inflammatory disease, an autoimmune disease and for tissue transplant rejection using therapeutic dosing regimen of anti-αβ TCR antibodies and antibody fragments and for upregulating the numbers of Treg T-cells are also provided.
US08524233B2 Monoclonal antibody and a method thereof
The present invention relates to a humanized IgG1 isotype anti-CD6 antibody (T1h) that binds to the Scavenger receptor cysteine-rich (SRCR) domain 1 (D1) of CD6 present on the surface of thymic epithelial cells, monocytes, activated T cells and a variety of other cells types.
US08524231B2 Antigen binding polypeptides
The invention relates to a platform technology for production of antigen binding polypeptides having specificity for a desired target antigen which is based on the conventional antibody repertoire of species in the family Camelidae, and to antigen binding polypeptides obtained using this technology platform. In particular, the invention provides an antigen binding polypeptide comprising a VH domain and a VL domain, wherein at least one hypervariable loop or complementarity determining region (CDR) in the VH domain or the VL domain is obtained from a VH or VL domain of a species in the family Camelidae.
US08524229B2 Medicament and a method for regulation of the vascular tone
The method of treatment for diseases accompanied by disturbances of the vascular tone utilizes the use of ultra low doses of antibodies to a protein or a peptide involved in the vascular tone regulation or mediating the effects of other regulators; these antibodies are used in activated form produced by multiple subsequent dilution and external impact.
US08524225B2 Use of proline specific endoproteases to hydrolyse peptides and proteins
The present invention relates to a process for the proteolytic hydrolysis of a peptide or a polypeptide, said peptide or polypeptide comprising 4 to 40, preferably 5 to 35, amino acid residues and said peptide or polypeptide is not hydrolysable by subtilisin whereby said peptide or polypeptide is hydrolysed by a proline specific endo protease at a pH of 6.5 or lower, preferably 5.5 or lower and more preferably 5.0 or lower to hydrolyse said peptide or polypeptide.
US08524221B2 Methods and compositions for gene inactivation
Disclosed herein are methods and compositions for inactivating CCR-5 genes, using zinc finger nucleases (ZFNs) comprising a zinc finger protein and a cleavage domain or cleavage half-domain. Polynucleotides encoding ZFNs, vectors comprising polynucleotides encoding ZFNs, such as adenovirus (Ad) vectors, and cells comprising polynucleotides encoding ZFNs and/or cells comprising ZFNs are also provided.
US08524218B2 Compositions and methods for treatment of neoplastic disease
The present invention comprises the use of sickle cells or sickle cell precursors loaded with a therapeutic agent that localize in tumors and induce a tumoricidal response.
US08524217B2 MCP1-Ig fusion variants
The present invention provides, in part, MCP1-Ig fusion polypeptides exhibiting surprisingly beneficial properties as well as methods for treating various diseases (e.g., inflammatory diseases) by administering any of such fusions.
US08524216B2 Sterilizing polymer and method of preparation thereof
The present invention provided a polymer and a method for preparing the polymer, wherein the polymer was a terpolymer having a molecular weight of more than 1000, and copolymerized by acrolein, acrylic acid, and low alkene-alkyl dibasic acid or low-alkene-alkyl polybasic acid.
US08524214B2 Polyal drug conjugates comprising variable rate-releasing linkers
Polyal-Drug conjugates comprising a variable rate-releasing linker are described along with methods of making such conjugates. Uses for such Polyal-Drug conjugates is also described.
US08524212B2 Prophylactic and/or therapeutic drug for nonalcoholic steatohepatitis
The present invention provides a method for the treatment of nonalcoholic steatohepatitis with a pharmaceutically acceptable anion exchange resin such as, for example, colestimide.
US08524211B1 Vegetable sourced petrolatum cosmetic
A cosmetic composition is provided which includes a triglyceride, a castor oil, glycerin, and a polyglyceryl ricinoleate. The composition is a vegetable sourced alternative to petrolatum and has been found to be an excellent moisturizing composition and delivering good skinfeel properties and lustre to skin.
US08524209B2 Composition for the permanent shaping of human hair
The present invention concerns a composition for the permanent shaping of human hair comprising a copolymer of vinylpyrrolidone and quaternized vinylimidazole at a concentration in the range of 0.1 to 2.5% by weight calculated to total composition and process for permanent shaping human hair with the said compositions.
US08524207B2 Cosmetic compositions
The present invention relates to a solid cosmetic composition which includes a soap and/or a non-soap surfactant, a hair modification active and/or skin enhancing agent, and at least one silicone and/or mineral oil.
US08524206B2 Aqueous polyamine-containing carrier systems for water-insoluble materials
The present invention is drawn to a carrier composition containing: (a) at least one polyamine compound comprising at least two amino groups; (b) at least one nonionic surfactant; (c) at least one anionic silicone; and (d) at least one water-insoluble material, and wherein the composition, when combined with an aqueous phase, forms an aqueous delivery system which is both stable, and clear to slightly hazy/limpid in appearance.
US08524200B2 Tooth whitening products
A tooth whitening product is provided. The tooth whitening product has a backing layer and a tooth whitening composition. The tooth whitening composition includes first and second water soluble polymers, water, and a tooth whitening agent, wherein the first water soluble polymer is polyethelene oxide and the second water soluble polymer is polyvinyl alcohol.
US08524198B2 Xylitol dental maintenance system
A kit for promoting oral hygiene, and a method for using such a kit are disclosed. The kit may comprise several compositions or a single composition, each of which comprises an effective amount of xylitol. For example, the kit may comprise a chewing gum composition, a morsel composition, a paste-like composition, and an oral rinse composition; or any one of the above compositions; or any combination thereof. It will be appreciated that a novel method for using such a kit for promoting oral hygiene may include: brushing a user's teeth with the paste-like composition comprising at least about 0.05 g to about 0.75 g of xylitol at least in the morning and in the evening, administering at least about 0.75 g of xylitol after consumption of nutrition by chewing a gum composition or by partaking of a morsel composition, and rinsing the user's oral cavity with an oral rinse composition comprising at least about 0.75 g of xylitol at least before bedtime.
US08524193B2 Non-invasive diagnostic imaging technology for mitochondria using radiolabeled lipophilic salts
The invention provides lipophilic salts, particularly, lipophilic salts comprising a pharmaceutically acceptable anion and at least one phosphonium or ammonium cation. In certain embodiments, the cation is labeled with one or more radioisotopes. The lipophilic salts of the invention exhibit an affinity for dysfunctional mitochondria, and are useful for the imaging of cardiovascular diseases and disorders. The invention also provides pharmaceutical compositions and methods of using the lipophilic salts.
US08524191B2 Process for preparing high-purity aluminum oxide by purification of alumina
A process for preparing aluminum oxide with a low calcium content, in which (1) crude alpha- and/or gamma-aluminum oxide with a total calcium content in the range from 50 to 2000 ppm, based on the crude alpha- and/or gamma-aluminum oxide, is mixed with an aqueous solution or suspension comprising the compounds selected from the group of inorganic acid, organic acid and complexing agent, (2) the mixture from step (1) is admixed with a flocculating aid, (3) in the mixture of step (2), the solids are separated from the liquid, (4) the solids separated are mixed with water in the presence or in the absence of a flocculating aid, (5) in the mixture of step (4), the solids are separated from the liquid, (6) optionally, steps (4) and (5) are repeated once or more than once, (7) optionally, the solids separated optionally after addition of further compounds, are dried.
US08524187B2 Thermal oxidisers, using concentrated sunlight
A VOC treatment apparatus is provided for treating substantially opaque VOCs and comprises a processing chamber (24) in which VOCs are treated; and a solar energy introducing device (8). The solar energy introducing device (8) comprises a tubular structure having a first end located external to the processing chamber (24) and having a first inlet (14) through which concentrated sunlight is received and a second inlet (16) through which a flow of substantially optically transmittant gas is received. The solar energy introducing device (8) has a second end (18) that opens into the processing chamber (24) and terminates in a nozzle providing an outlet for the substantially optically transmittant gas and the concentrated sunlight. In use the optically transmittant gas exits the second end of the device in a jet to create an optically transmittant zone in the substantially opaque VOCs within the processing chamber (24), in which zone the sunlight can travel.
US08524186B2 Carbon-based catalyst for flue gas desulfurization and method of producing the same and use thereof for removing mercury in flue gas
A carbon-based catalyst for flue gas desulfurization is brought into contact with a flue gas containing at least SO2 gas, oxygen and water vapor so that the SO2 gas can react with the oxygen and the water vapor to form sulfuric acid which is to be recovered. On a surface of the carbon-based catalyst, iodine, bromine or a compound thereof is added, ion exchanged or supported and a water-repellent treatment is applied. The carbon-based catalyst can also be used as a mercury adsorbent for flue gas treatment for adsorbing and removing metallic mercury from a flue gas containing metallic mercury, SO2 gas, oxygen and water vapor.
US08524179B2 Hot-side method and system
The present disclosure is directed to the use of elemental or speciated iodine and bromine to control total mercury emissions.
US08524178B2 Doped aluminum oxides
A process of preparing a doped aluminum oxide, includes providing a solution comprising 8-hydroxyquinoline; an aluminum precursor; a dopant precursor, and a reaction solvent; isolating a precipitate from the solution; and calcining the precipitate to form the doped aluminum oxide. Compositions may be prepared which include tris(8-hydroxyquinolinato) aluminum and (8-hydroxyquinolinato)zM, wherein M is a metal ion and the value of z is equivalent to the oxidation state of the metal ion.
US08524176B2 Rare earth recovery from phosphor
A method is described to produce high purity rare earth oxides of the elements La, Ce, Tb, Eu and Y from phosphor, such as waste phosphor powders originating in various consumer products. One approach involves leaching the powder in two stages and converting to two groups of relatively high purity mixed rare earth oxides. The first group containing Eu and Y is initially separated by solvent extraction. Once separated, Eu is purified using Zn reduction with custom apparatus. Y is purified by running another solvent extraction process using tricaprylmethylammonium chloride. Ce is separated from the second group of oxides, containing La, Ce and Tb by using solvent extraction. Subsequently, La and Tb are separated from each other and converted to pure oxides by using solvent extraction processes. A one-stage leaching process, wherein all rare earths get leached into the solution and subsequently processed, is also described.
US08524174B2 Fluid cartridge, pump and fluid valve arrangement
A fluid cartridge, comprising a channel layer within which at least one circumferentially sealed fluid channel is formed, the channel layer comprising a substrate and an elastic layer fixedly arranged on the substrate, wherein the substrate has a rigidity being greater than that of the elastic layer, and wherein the at least one fluid channel is defined on at least one side thereof by the elastic layer.
US08524168B2 Holding device for medical test strip
A device for holding a medical test strip is provided. The device comprises a receiving casing having an opening for receiving the medical test strip and a first stopping portion protruding from an upper surface of the receiving casing; an ejection base having a cover and a pusher beneath the cover, the cover downwardly extending a second stopping portion for sliding against the upper surface of the receiving casing; and an elastic member located between the receiving casing and the ejection base. When the pusher moves toward the opening by an external force to eject the test strip from the opening, the elastic member is compressed and the second stopping portion slides away from the first stopping portion. When the external force disappears, the second stopping portion slides toward the first stopping portion by a resilient force of the elastic member until the first stopping portion and the second stopping portion are engaged.
US08524167B2 Chlorine dioxide decontamination system and method
A system includes a portable source of gaseous chlorine dioxide (CD). The source has first source and return couplings for sealingly connecting to a CD generation flow path comprising at least one gas conduit. The CD generation flow path comprises second source and return couplings for sealingly connecting the source to a device to be treated with the CD generation flow path, or a tent structure enclosing the device to be treated. A portable scrubber has third couplings for sealingly connecting to a scrubbing flow path comprising at least one gas conduit for removing the CD from the device or tent structure. The gas conduit has fourth couplings for connecting the device or tent structure to the scrubbing flow path.
US08524163B2 Ozone generating apparatus
An ozone generating apparatus is provided which includes a pair of electrodes for producing a discharge by the application of an ac voltage therebetween, and at least one dielectric provided between the pair of electrodes. A source gas containing oxygen is provided into a discharge space in which the discharge is produced to generate ozone by the action of the discharge. A surface lying between at least one of the pair of electrodes and the discharge space and in contact with the discharge has a surface resistivity of 104Ω to 1011Ω. The source gas provided into the discharge space includes ultrapure oxygen having a purity of not less than 99.9%.
US08524161B2 Multiple layer substrate support and exhaust gas treatment device
A mat or mat-pre-form hybrid for use in an exhaust gas treatment device, such as catalytic converters and diesel particulate traps that are used in automotive exhaust systems. The mat or hybrid may be used as a mounting mat to mount a fragile monolith within an outer housing of an exhaust gas treatment device or as thermal insulation in an end cone of the exhaust gas treatment device.
US08524159B2 Reactor with reactor head and integrated valve
A reactor with minimal dead volume especially suited to reverse-flow applications comprises: a) a reactor body; b) a first head engaged with said reactor body; c) a first conduit extending from outside said head to at least partially through said head; and d) a first valve in flow communication with said first conduit controlling fluid flow along a flow path extending from the first valve and through the reactor body. The reactor is especially suited for use in a process for rapid stream-switching of at least two streams in a reverse-flow reactor.
US08524157B2 Container having an oxygen scavenging activation system
A polyethylene terephthalate container having a hydrogen generator and catalyst disposed or otherwise incorporated in components of the container. The container further comprises an activation system or means for activating the hydrogen generator and/or catalyst system at a predetermined time or in response to a predetermined stimulus.
US08524156B2 Tube bundle reactor
A tube bundle reactor carries out endothermic or exothermic gas phase reactions. The tube bundle of reactor tubes are filled with catalyst, and have their ends fastened tightly in tube sheets (3, 4). A fluid heat carrier (10) flows around the tubes during operation. A shell (5) encloses the tube bundle. A gas inlet head (6) spans one of the tube sheets, and a gas outlet head (7) spans the other tube sheet. The reactor tubes are in fluid communication with the gas inlet and outlet heads (6, 7), and further include at least one stage thermometer (9) installed in a thermometer tube (2) disposed in the tube bundle. The at least one stage thermometer (9) is axially movable inside the thermometer tube (2), and the tube bundle reactor (1) includes a mechanical positioning means (8) to effect the axial movement of the stage thermometer (9). Moreover, a method is proposed for measuring a temperature profile in tube bundle reactors of the kind specified.
US08524150B2 Dental alloy with a high gold content that is devoid of palladium and copper
A dental alloy with a high gold content that is devoid of palladium and copper. To achieve high mechanical stability, the dental alloy contains between 75 and 95 wt. % Au, between 5 and 20 wt. % Pt, between 0.5 and 3.5 wt. % Zn and/or Sn and/or In, between 0.1 and 0.8 wt. % of an element of a group I, in addition to a single particle refiner of a group II. The weight fraction of the element of group I is between 2 and 6 times that of the single particle refiner of group II, and one element of group I is represented by Nb or Ta or Ti or V and the particle refiner of group II is represented by Ir or Rh.
US08524145B2 Method and device for introducing dust into a metal melt of a pyrometallurgical installation
A device for introducing dust into a molten bath of a pyrometallurgical installation is provided. An electrodeless plasma torch includes an essentially tubular housing, wherein the housing allows a passage of a carrier gas containing dust particles, and wherein the housing is coaxially surrounded by an inductive load coil which forms a heating zone.
US08524141B2 Method of making a card sheet
A card sheet including a top material having punched lines, the front side of the top material being printable. A carrier material of at least one polymer layer is directly applied as by extruding to the back side of the top material. The polymer has a stress-at-break in the range of 10 to 30 MPa and an elongation at break in the range of 10 to 120%. From the card sheet individual cards may be broken out to form high quality calling (business) cards, photograph cards, post cards or the like.
US08524140B2 Process of making nanofibers
A container having a plurality of orifices in an outer peripheral wall and having a space communicating with the orifices is rotated to extrude an electrically charged raw material liquid containing a polymer material from the space through the orifices by centrifugal force. This allows the electrically charged raw material liquid to form a fibrous material. At this time, the raw material liquid is supplied to the space in which the raw material liquid is filled by a raw material liquid pump so that the raw material liquid is extruded from the orifices at a predetermined pressure. That is, the raw material liquid in the space is pressurized. Also, the shape of the space in the container is set so that the centrifugal force exerted on the raw material liquid is constant.
US08524139B2 Gas-assisted laser ablation
An improved method for laser processing that prevents material redeposition during laser ablation but allows material to be removed at a high rate. In a preferred embodiment, laser ablation is performed in a chamber filled with high pressure precursor (etchant) gas so that sample particles ejected during laser ablation will react with the precursor gas in the gas atmosphere of the sample chamber. When the ejected particles collide with precursor gas particles, the precursor is dissociated, forming a reactive component that binds the ablated material. In turn, the reaction between the reactive dissociation by-product and the ablated material forms a new, volatile compound that can be pumped away in a gaseous state rather than redepositing onto the sample.
US08524138B2 Concrete block with beveled core opening edge
Methods and equipment for forming beveled edge(s) around the core opening in a concrete block are disclosed. The formation of the beveled edge(s) minimizes feathering along the block edges that are beveled as the block is stripped from a mold. Any feathering that does occur is shifted away from the bottom surface of the block to allow the block to lay flat on other blocks when dry stacked in a wall.
US08524136B2 Imprint lithography
An imprint template cover for an imprint template having a pattern feature thereon. The cover is configured such that, in use, it extends around the pattern feature of the imprint template, and such that the cover does not contact the pattern feature.
US08524133B2 Method for manufacturing resin film for thin film-capacitor and the film therefor
The present invention provides a method for manufacturing a film for a film capacitor making it possible to produce a film for a film capacitor which has a thickness of 10 μm or less and which is excellent in a heat resistance and a voltage resistance at a high thickness accuracy by using a polyetherimide resin and provides as well a film for a film capacitor. The above manufacturing method comprises the steps of: feeding a molding material 1 containing a polyetherimide resin into an extruding machine 10, extruding a film 50 for a film capacitor immediately downward from a lip part 21 at a tip of a T dice 20 thereof, interposing the film 50 for a film capacitor between a pressing roll 31 and a cooling roll 33 to cool it and winding up the cooled film 50 for a film capacitor having a thickness of 10 μm or less on a winding equipment 40, wherein assuming that a shear rate of the molten molding material 1 in the lip part 21 of the T dice 20 is set to γ [/s] and that a circumferential speed of the cooling roll 33 is set to V [m/s], a ratio V/γ [m] of a circumferential speed V of the cooling roll 33 to a shear rate γ of the molding material 1 falls in a range of 3.0×10−2 to 90×10−2 [m].
US08524127B2 Method of manufacturing a panel with occluded microholes
Methods of manufacturing a panel and resulting panels include a plurality of microholes arranged in a pattern and filled with light transmissive polymeric material. The light transmissive polymeric material occludes the microholes and is set, or cured, by exposure to an energy source using at least two discrete exposure periods separated by an idle or rest period.
US08524125B2 Washing-fast smoldering-suppressing compositions
Novel smoldering suppressing compositions containing a metal complex of ammonium superphosphoric acid and having a high phosphate content, and processes for their preparation, are disclosed. Further disclosed are formulations containing these compositions and articles-of-manufacture having these formulations applied thereon. These novel formulations are particularly effective as smoldering suppressants for textiles, and are characterized by a high washing fastness.
US08524124B2 Dispersion of zirconium oxide and process for producing the same
The invention provides a process for producing an aqueous dispersion of zirconium oxide comprising: reacting a zirconium salt with an alkali in water to obtain a slurry of particles of zirconium oxide; filtering, washing, and repulping the slurry; adding an organic acid to the resulting slurry in an amount of one mole part or more per mole part of the zirconium in the slurry; hydrothermally treating the resulting mixture at a temperature of 170° C. or higher; and washing the resulting aqueous dispersion of particles of zirconium oxide.
US08524122B2 Method of producing ITO particles
A production method capable of producing ITO particles without using a solvent with a high boiling point as a solvent used in the producing step by a simple treatment method without through a heating process in an atmosphere which disadvantageously causes sintering among the ITO particles to coarsen the ITO particles. An ITO powder suitable for a coating material for a transparent electroconductive material, being produced by a first step of dissolving salt containing indium and salt containing tin into an organic solvent, then adding to this organic solvent, an organic solvent containing a basic precipitant, to thereby manufacture a mixture of a precursor containing indium and tin, and the organic solvent; and a second step of applying heat treatment to the mixture of the precursor containing indium and tin, and the organic solvent in a pressurizing vessel at 200° C. or more and 300° C. or less, to generate ITO particles.
US08524116B2 Optical compensatory film, process for producing the same, and polarizing plate and liquid crystal display employing the same
A novel optical compensatory sheet comprising an optically anisotropic layer comprising at least one liquid crystal compound, at least one cellulose ester, and at least one polymer A comprising at least one repeating unit derived from a monomer having a fluoro-aliphatic group, and at least one repeating unit having a group selected from the group consisting of carboxyl group (—COOH) or a salt thereof, a sulfo group (—SO3H) or a salt thereof and a phosphonoxy group {—OP(═O) (OH)2} or a salt thereof, is disclosed. A novel optical compensatory sheet comprising an optically anisotropic layer comprising at lest one liquid crystal compound at least one polymer C, having a weight average molecular weight of not less than 5000 and less than 20000, represented by a formula (1b), and at least one polymer D, having a weight average molecular weight of not less than 20000, represented by a formula (1b), is also disclosed. In the formula, “A” represents a repeating unit having a group capable of hydrogen bonding, “B” represents a repeating unit having a polymerizable group, and “C” represents a repeating unit derived from an ethylene-type unsaturated monomer. -(A)ai-(B)bj-(C)ck-  Formula (1b)
US08524115B2 Adsorptive composite barriers for packaging applications
A method of selecting an appropriate resin bonded sorbent composition which may be used at least for in part making an enclosure to protect contents from external humidity including the steps of: a) selecting a plurality of resins, a plurality of sorbents and a plurality of ratios therebetween to form a plurality of composites; b) calculating a plurality of failure times for the plurality of composites, wherein each failure time of the plurality of failure times is based on when an internal relative humidity of each composite of the plurality of composites is equal to the maximum internal relative humidity; c) determining which of the plurality of failure times is greater; and, d) selecting one composite of the plurality of composites based on the result of step (c).
US08524114B2 Nitrates
A method of producing anhydrous calcium nitrate, anhydrous magnesium nitrate or mixture thereof involves removing water from a solution of calcium nitrate, magnesium nitrate or mixture thereof in a pulse combustion drier. The invention also provides a mixture of anhydrous calcium nitrate, anhydrous magnesium nitrate and the individual anhydrous nitrate salts in a sealed container.
US08524110B2 Compositions comprising a fluoroolefin
The present invention relates to compositions for use in refrigeration, air-conditioning, and heat pump systems wherein the composition comprises a fluoroolefin and at least one other component. The compositions of the present invention are useful in processes for producing cooling or heat, as heat transfer fluids, foam blowing agents, aerosol propellants, and fire suppression and fire extinguishing agents.
US08524105B2 Environmentally beneficial and effective hydrochlorofluorocarbon compositions for fire extinguishing applications
Compositions are described which are useful in many applications such as fire extinguishing or refrigeration. The compositions may include a hydrochlorofluorocarbon such as 2,2-dichloro-1,1,1-trifluoroethane, a dispersant such as CF3I, and an inert gas such as argon, and may in some embodiments be held under pressure. For example, some fire extinguishing compositions may be composed of 2,2-dichloro-1,1,1-trifluoroethane, CF3I, and argon.
US08524104B1 Fluoroalkenyl sulfate surfactants
Fire extinguishing compositions and methods of extinguishing a fire comprising compounds of formula (I) where Rf is a fluorocarbon group. The compounds and compositions described herein are useful as intermediates in the preparation of or as additives to AFFF (aqueous film forming foam) formulations used for the extinguishment of fuel and solvent fires.
US08524101B2 Method and apparatus for manufacturing semiconductor device, and storage medium
The present invention provides a method for manufacturing a semiconductor device. In the method, a connection hole such as a via hole is formed in an interlayer insulating film by plasma etching with high etching uniformity regardless of the array density of connection holes. In the method, an upper layer film having a mask pattern is formed on the interlayer insulating film present on a substrate. A gas required for dehydration is then supplied to the substrate under the condition that an upper surface of the interlayer insulating film is exposed in order to remove moisture from the interlayer insulating film. A portion of the interlayer insulating film is etched to form a connection hole in which an electrical connection portion is to be embedded.
US08524097B2 Plasma deposition to increase adhesion
Plasma etching of a liquid dielectric material such as a polyurethane solution results in volatile byproducts that are deposited onto the surface of an inert substrate. The surface treatment increases adhesiveness so that the surface of the inert material may be bonded to another material. Portions of a medical device comprising an inert substrate such as a fluoropolymer may therefore be securely affixed to other portions of the medical device formed of polymeric, metallic, or ceramic materials.
US08524094B2 Masking material for dry etching
The object of the present invention is to provide a masking material for dry etching, which is suitable for fine processing of a magnetic film as thin as a few nm such as NiFe or CoFe constituting a TMR film and capable of simplifying the process for producing a TMR element and reducing production costs related to facilities and materials. This object was solved by a masking material for dry etching of a magnetic material by using a mixed gas of carbon monoxide and a nitrogenous compound as etching gas, which comprises a metal (tantalum, tungsten, zirconium or hafnium) with a melting or boiling point increasing upon conversion thereof into a nitride or carbide.
US08524093B2 Method for forming a deep trench
A method for forming a deep trench includes providing a substrate with a bottom layer and a top layer; performing a first etching process to etch the top layer, the bottom layer and the substrate so as to form a recess; selectively depositing a liner covering the top layer, the bottom layer and part of the substrate in the recess; using the liner as an etching mask to perform a second dry etching to etch the recess unmasked by the liner so as to form a deep trench; performing a selective wet etching to remove the top layer; and performing a post wet etching to enlarge the deep trench.
US08524092B2 Dry adhesives and methods for making dry adhesives
A dry adhesive and a method of forming a dry adhesive. The method includes forming an opening through an etch layer and to a barrier layer, expanding the opening in the etch layer at the barrier layer, filling the opening with a material, removing the barrier layer from the material in the opening, and removing the etch layer from the material in the opening.
US08524091B2 Apparatus, system, and method for filtration of a dosing fluid in an exhaust aftertreatment system
An apparatus, system, and method are disclosed for a filter for filtering a dosing fluid in an exhaust aftertreatment system. The filter may comprise a dosing tank configured to contain a dosing fluid, a filter media disposed within the dosing tank, and a support structure supporting the filter media to form a pathway for a flow of dosing fluid. Beneficially, the apparatus, system, and method of the present invention reduce the cost of operation and manufacture of the SCR system.
US08524090B2 Blood processing filter
A flexible blood filter allowing smooth flow of a liquid and being excellent in separation resistance, pressure resistance and centrifugation resistance. The blood processing filter, comprising a first filter element for removing aggregates from blood, a second filter element for removing leukocytes provided in the downstream of the first filter element, and the third filter element having gas permeability of 3 to 40 cc/cm2/sec per thickness of 1 cm provided between the second filter element and the outlet port side container.
US08524089B2 Combined sedimentation and pressure floatation wastewater treatment tank
A combined sedimentation and pressure floatation wastewater treatment tank includes a tank body, a sedimentation treatment device and a pressure floatation treatment device. The tank body contains a predetermined amount of wastewater for treatment. The sedimentation treatment device is used to remove relatively heavier sludge from the wastewater by sedimentation treatment, and the pressure floatation treatment device is used to remove relatively lighter sludge from the initially treated wastewater by pressure floatation treatment. In operation, the wastewater is initially treated by the sedimentation treatment device and is further treated by the pressure floatation treatment device. Alternatively, the wastewater is initially treated by the pressure floatation treatment device and is further treated by the sedimentation treatment device.
US08524088B2 Method to inhibit scale formation in cooling circuits using carbon dioxide
Scaling is controlled in a cooling water system with CO2 based upon measurements of the cooling water's pH, alkalinity and Ca2+concentration.
US08524087B2 Low metal, low water biomass-derived pyrolysis oils and methods for producing the same
Low metal, low water biomass-derived pyrolysis oils and methods for producing the same are provided. Metal- and water-containing biomass-derived pyrolysis oil is contacted with an acidic ion-exchange resin having sulfonic acid groups to produce a low metal, water-containing biomass-derived pyrolysis oil. The low metal, water-containing biomass-derived pyrolysis oil is removed from the spent ion-exchange resin after ion-exchange. The low metal, water-containing biomass-derived pyrolysis oil is distilled to produce a low metal, low water biomass-derived pyrolysis oil and a distillation product. The distillation product comprises one or both of an alcohol ion-exchange regenerant and an acidic ion-exchange regenerant which may be used to regenerate the spent ion-exchange resin. The regenerated acidic ion-exchange resin may be recycled. The spent alcohol and acid ion-exchange regenerants may be recovered and recycled.
US08524084B2 Wastewater treatment
A wastewater treatment system includes wastewater having nitrogen-containing compounds, an anoxic zone having denitrifying bacteria, and an aerobic zone having nitrifying bacteria. The anoxic zone is coupled to the aerobic zone, and wastewater flows from the anoxic to the aerobic zone or vice versa. A fluidized bed heat exchanger configured to accept heat from a heat engine and to transfer the heat from the heat engine to the wastewater is positioned in the aerobic zone or the anoxic zone. The fluidized bed heat exchanger includes particulate media, and fluidization of the particulate media scrubs bacterial growth from portions of the fluidized bed heat exchanger. Treating wastewater can include flowing wastewater having nitrogen-containing compounds into a biological reactor having an anoxic zone and an aerobic zone, and heating the wastewater with heat from a heat engine to facilitate denitrification reactions in the anoxic zone and nitrification reactions in the aerobic zone.
US08524082B2 Mechanical axial vibration in membrane separation treatment of effluents
Apparatus and methods are disclosed for mechanical axial vibration in membrane separation treatment processes. The apparatus includes a separation membrane element having an axial dimension, a membrane support structure having the element therein, and means for vibrating the membrane element (hydrodynamically or using motors) in the axial dimension.
US08524079B1 Assembling structure for a filtration set
An assembling structure for a filtration set includes a filter set having a plurality of filter cases, the filter cases assembled together, an assembling portion extruded on an outer surface of each filter case, the assembling portion extending from a top to a bottom of each filter case, at least one assembling plate having two ends which are respectively extruded from each side of the assembling portion and the outer surface of the corresponding filter case, the assembling plate having a positioning block at a periphery thereof, a plurality of bolts used to be inserted through the positioning block of each filter case. Wherein, a user can assemble the filter cases together via the positioning block and the bolt.
US08524074B2 Removal of mercury and mercuric compounds from crude oil streams
The invention is directed towards a method of removing mercury bearing species from a hydrocarbon containing fluid. The method comprises the steps of: i) adding dithiocarbamate polymer to the fluid in an amount such that the number of mercury bonding sites on the polymer exceeds the amount of mercury atoms by at least 10% and ii) removing the mercury bearing dithiocarbamate polymer with a water/oil separation device. The invention relies upon an unexpected reversal in the solubility of dithiocarbamate polymer at very high concentrations. Because of the high solubility the polymer remains within the water phase of the hydrocarbon fluid and can be removed without the need for cumbersome precipitation methods and complicated solid liquid separation devices. As a result, the invention allows mercury contaminated crude oil to be easily rid of its mercury with easy to use equipment already present in a typical oil refinery.
US08524073B2 Surface modified sorbent
Disclosed herein is a sorbent composition including an adsorbent support; and a metal component comprising a transition metal, wherein the metal component is impregnated on a surface of the adsorbent support; and wherein the metal component effects the removal of sulfur and vanadium from a hydrocarbon fuel. Also disclosed herein is a sorbent composition comprising an adsorbent support, wherein a surface of the adsorbent support has been chemically modified to comprise functional groups; and wherein the adsorbent support effects the removal of sulfur and vanadium from a hydrocarbon fuel.
US08524062B2 Electrodeionization device and method with improved scaling resistance
An electrodeionization apparatus includes an anode compartment provided with an anode and a cathode compartment spaced from the anode compartment and provided with a cathode, wherein the anode and cathode are configured for coupling to a DC power source to effect an electric potential difference between the anode and the cathode and thereby influence transport of ionic material in liquid media and ion exchange media by the influence of the electric potential difference. The electrodeionization apparatus also includes a feed inlet receiving a feed solution, a product water outlet and a plurality of anion exchange membranes and a plurality of cation exchange membranes alternately arranged between the anode compartment and the cathode compartment. The electrodeionization apparatus also includes a plurality of spacers, wherein the spacers and the anion and cation exchange membranes are arranged to form a first diluting compartment receiving feed solution from the feed inlet, a second diluting compartment in series with the first diluting compartment and delivering product water to the product water outlet, a first concentrating compartment and a second concentrating compartment. The first and second diluting compartments are bounded by an anion exchange membrane on the side closest to the anode and by a cation exchange membrane on the side closest to the cathode. The first and second concentrating compartments are bounded by a cation exchange membrane on the side closest to the anode and by an anion exchange membrane on the side closest to the cathode.
US08524058B2 Low power amperometric probe
An amperometric probe suitable for monitoring chlorine levels in water is described. The probe has low power consumption and maintenance requirements rendering it particularly suitable for long periods of operation in remote locations with portable power supplies.
US08524056B2 Electrochemical corrosion potential sensor
An electrochemical corrosion potential sensor (ECP sensor) has an electrode cap, an electrode fixing body, a tubular insulator, a tubular metallic housing, and a conductive wire. Both ends of the tubular insulator are connected to the electrode fixing body and the tubular metallic housing respectively. A conductive wire passes through the tubular insulator and the tubular metallic housing, and is connected to an inner surface of the electrode fixing body. The electrode cap 11 disposed to cover an outer surface of the electrode fixing body. The ECP sensor with such a construction can lengthen the lifetime.
US08524052B1 Cooling shower plate for disk manufacture
Apparatus and method for cooling a recording media disk in a deposition system. A manifold spacer including an input port to receive a coolant gas and a first output port to output the coolant gas couples a pair of cooling plates together, the pair of cooling plates having opposing surfaces spaced apart by the manifold spacer to accommodate a passage of disks to be cooled. A first shower manifold is coupled to a first of the pair of cooling plates, the first shower manifold receives the coolant gas from the first output port in the manifold spacer and outputs the coolant gas flow in a first direction perpendicular to the opposing cooling plate surfaces and toward the media disk to be cooled.
US08524051B2 Coated article with oxidation graded layer proximate IR reflecting layer(s) and corresponding method
A coated article is provided that may be heat treated in certain example embodiments. A graded layer (e.g., contact layer or other suitable layer) is formed by initially sputter-depositing a layer, and thereafter ion beam treating the sputter-deposited layer with at least reactive gas ions in order to form a graded layer. In certain example embodiments, the result is a coated article that has improved visible transmission and/or durability, without sacrificing optional heat treatability.
US08524049B2 Method for forming metallic nitride film
A method for forming a metallic nitride film includes the steps of a) providing a target made of titanium or zirconium and a substrate in a vacuum chamber, and b) forming a metallic film, which is a TiN film or a ZrN film, on a surface of the substrate by sputtering deposition under the conditions of maintaining a working pressure of the vacuum chamber in a range of 5×10−4 Torr to 5×10−2 Torr; introducing a gas mixture of air and argon into the vacuum chamber at a flow rate ratio of the air to the argon ranging from 5:100 to 15:100, and applying a direct current power ranging from 100 Watts to 5000 Watts by a power supply. Because air can be conveniently collected and the requirement of the base pressure is lower than that of a prior art method, the method of the present invention has the advantages of simple equipment requirement, time-effective manufacturing processes and low cost.
US08524040B2 Method of making a belt-creped absorbent cellulosic sheet
A method of making a belt-creped absorbent cellulosic sheet includes compactively dewatering a papermaking furnish to form a nascent web having an apparently random distribution of papermaking fiber orientation, applying the nascent web having the apparently random distribution of fiber orientation to a translating transfer surface that is moving at a transfer surface speed, belt-creping the web from the transfer surface at a consistency of from about 30% to about 60% utilizing a patterned creping belt, the belt-creping step occurring under pressure in a belt creping nip defined between the transfer surface and the creping belt, the web being creped from the transfer surface and redistributed on the creping belt to form a web with a reticulum having a plurality of interconnected regions of different local basis weights.
US08524038B2 Bleaching process of chemical pulp
A process for the bleaching of chemical pulp, wherein the initial bleaching of the pulp includes a first chlorine dioxide treatment (D0) and a following alkaline treatment with oxygen and hydrogen peroxide (EOP), which stages are separated from each other with a washing stage, and a treatment of the pulp to reduce the content of transition metals of the pulp prior to the peroxide treatment. The process is characterized in that alkali is added to the pulp after addition of chlorine dioxide in the D0 stage to adjust the pH of the pulp to neutral or basic (N stage) prior to the washing stage following the chlorine dioxide stage, whereby the initial bleaching includes the sequence D0N EOP.
US08524028B2 Laminate assembly sealing method and arrangement
An example method of sealing a laminate assembly includes preloading a laminate assembly having a plurality of laminations, pressurizing the laminate assembly, and pressurizing an enclosed volume disposed adjacent an end portion of the laminate assembly to hold the laminations in sealed positions.
US08524026B2 Former for fabricating a composite material casing for a gas turbine
A former for fabricating a gas composite material casing for a gas turbine, which is obtained by forming fiber reinforcement as superposed layers of a fiber texture and densifying the fiber reinforcement with a matrix, is disclosed. The former has two cheekplates and an annular wall with an outside surface presenting a profile that corresponds to the profile of the inside surface of the casing that is to be fabricated. The annular wall of the former includes a removable fastener device for fastening a fiber texture layer and serving to hold the first layer of the fiber texture mechanically while the fiber texture is being wound on the former.
US08524025B2 One-piece inner shell for full barrel composite fuselage
A mandrel for manufacturing a unitary seamless section of an aircraft fuselage comprises a thin lay-up mandrel element disposed onto the outer shell surface of an inner mandrel shell, forming a mandrel with a substantially continuous lay-up surface. A unitary pre-cured section of an aircraft fuselage is formed by laying up a plurality of resin impregnated skin fibers onto the mandrel's lay-up surface while the mandrel rotates.
US08524022B2 Method of manufacturing a structure
A method of manufacturing a structure, the method comprising: forming a panel assembly by bonding a stack of thickness control plies of composite material to a laminar composite panel, the stack of thickness control plies having a first edge proximate an edge of the laminar composite panel, a second edge opposite the first edge, and a ramp where the thickness of the stack of thickness control plies decreases towards the first or second edge; measuring the thickness of the laminate composite panel or the panel assembly; controlling the number of thickness control plies in accordance with the measured thickness; attaching a first component to the panel assembly, the first component having a surface which engages the laminar composite panel and a ramp which engages the ramp in the stack of thickness control plies; and attaching the laminar composite panel at or near its edge to a further component.
US08524020B2 Method of restoring a composite airframe
A method of removing an out-of-tolerance area in a composite structure comprises determining the location of the out-of-tolerance area and selecting a volume of the composite structure to be removed based on the location of the out-of-tolerance area. The method may further include programming a machine tool to remove the volume and to pause after removal of each one of a quantity of layers of the volume. The method may additionally include removing one of the layers using the programmed machine tool. The method may further include restoring the volume removed using the programmed area removal digital definition.
US08524018B2 Percussion primers comprising a primer composition and ordnance including the same
A primer composition that includes stabilized, encapsulated red phosphorus, at least one oxidizer, at least one secondary explosive composition, at least one light metal, and at least one acid resistant binder. The stabilized, encapsulated red phosphorus may include particles of red phosphorus, a metal oxide coating, and a polymer layer. The metal oxide coating may be a coating of aluminum hydroxide, bismuth hydroxide, cadmium hydroxide, cerium hydroxide, chromium hydroxide, germanium hydroxide, magnesium hydroxide, manganese hydroxide, niobium hydroxide, silicon hydroxide, tin hydroxide, titanium hydroxide, zinc hydroxide, zirconium hydroxide, or mixtures thereof. The polymer layer may be a layer of epoxy resin, melamine resin, phenol formaldehyde resin, polyurethane resin, or mixtures thereof. A percussion cap primer that includes the primer composition, a tertiary explosive composition, and a cup is also disclosed, as are ordnance devices including the primer composition.
US08524016B2 Method of making an austempered ductile iron article
A method of making an austempered ductile iron article is disclosed. The method includes providing a melt of a ductile iron alloy composition. The method also includes casting the melt into a mold to form a casting. The method further includes cooling the casting to an austempering temperature by circulating a coolant through the mold; wherein cooling comprises solidifying the melt and forming a ductile iron article. Still further, the method includes heating the casting to maintain the austempering temperature for an interval sufficient to form an austempered ductile iron article that comprises a microstructure comprising ausferrite.
US08524013B2 Permanent magnet and manufacturing method thereof
There are provided a permanent magnet and a manufacturing method thereof capable of manufacturing metal alkoxide in better work environment, simpler production facilities and easier manufacturing process and also reducing the manufacturing costs. An electrolytic solution is obtained through dissolving chloride or injecting hydrogen chloride gas into alcohol which is same alcohol as is a constituent element of metal alkoxide to be manufactured. Then, electrolysis is performed on the electrolytic solution while using, for an anode, a ferroalloy that contains iron and metal which is a constituent element of the metal alkoxide to be manufactured in a predetermined weight ratio (such as 1:1), and, for a cathode, the same ferroalloy, carbon, platinum or stainless steel, so as to obtain an alcohol solution of the metal alkoxide. Then, a permanent magnet is manufactured using the alcohol solution of the metal alkoxide thus obtained.
US08524012B2 Technique for the growth of planar semi-polar gallium nitride
A method for growing planar, semi-polar nitride film on a miscut spinel substrate, in which a large area of the planar, semi-polar nitride film is parallel to the substrate's surface. The planar films and substrates are: (1) {1011} gallium nitride (GaN) grown on a {100} spinel substrate miscut in specific directions, (2) {1013} gallium nitride (GaN) grown on a {110} spinel substrate, (3) {1122} gallium nitride (GaN) grown on a {1100} sapphire substrate, and (4) {1013} gallium nitride (GaN) grown on a {1100} sapphire substrate.
US08524010B2 Transportable integrated wash unit
A transportable wash unit comprises a wash fluid delivery system for delivering wash fluid to a desired washing location; a power supply for providing power to components of the transportable washing unit; a unit controller for controlling one or more components of the transportable wash unit; and a mobility unit for mobilizing the transportable wash unit.
US08524009B2 Substrate treating method
A substrate processing method comprising: holding a substrate substantially horizontally by a rotatable substrate holding mechanism; supplying a rinsing liquid onto the top of the substrate held by the substrate holding mechanism at the substrate holding step; after the rinsing liquid supply step, spraying a gas onto the top of the substrate held by the substrate holding mechanism, by a gas knife mechanism, to form a gas spraying zone on the substrate top, and unidirectionally scanning the substrate top in its entirety by this gas spraying zone, without rotating the substrate; replenishing the rinsing liquid by supplying, in parallel to the gas knife spraying step, a rinsing liquid onto the substrate top at its area downstream in the gas-spraying-zone scanning direction rather than the gas spraying zone formed by the gas knife mechanism; and drying the substrate surface after the gas knife spraying step and the rinsing liquid replenishing step.
US08524008B2 Method and device for cleaning substrates on a carrier
In the case of a device and a method for cleaning substrates on a carrier, to the underside of which the substrates are fastened so as to be parallel to and slightly apart from one another, the carrier has in its interior a plurality of longitudinal channels, which run parallel to one another. As a result of the sawing of the wafers, they merge, via openings, into interstices between the substrates. As a result of a relative movement, an elongate tube, from which cleaning fluid is let out, is introduced into one of the longitudinal channels, the relative movement being achieved substantially through moving of the carrier.
US08524006B2 Target bodies and uses thereof in the production of radioisotope materials
A system and method are provided for reclaiming an enriched radioisotope starting material from a target body. The system and method enable reclaiming the starting material in a relatively short time (e.g., several hours) after the target body's bombardment with energetic particles, greatly simplifying the target body's chemical processing, as well as reducing the cost of such processing (e.g., reducing the need for costly long-term storage). Specifically, a chemical protective layer is disposed between a radioisotope starting material and a base material of the target body. After the target body is irradiated with a suitable source (e.g., particle accelerator), then the irradiated radioisotope starting material can be removed without removing the base material due to the protection provided by the chemical protective layer. The system and method also enable the operator to obtain three different radioisotopes in a single bombardment of the target body, further reducing cost of radioisotope production.
US08524004B2 Loadlock batch ozone cure
A substrate processing chamber for processing a plurality of wafers in batch mode. In one embodiment the chamber includes a vertically aligned housing having first and second processing areas separated by an internal divider, the first processing area positioned directly over the second processing area; a multi-zone heater operatively coupled to the housing to heat the first and second processing areas independent of each other; a wafer transport adapted to hold a plurality of wafers within the processing chamber and move vertically between the first and second processing areas; a gas distribution system adapted to introduce ozone into the second area and steam into the first processing area; and a gas exhaust system configured to exhaust gases introduced into the first and second processing areas.
US08524003B2 Loaded film cassette for gaseous vapor deposition
A cassette for supporting a film during a gaseous vapor deposition has first and second end plates. A rib on each end plate forms a spiral groove that edgewise receives a spiral wrapping of a film having a width greater than 300 mm. Spaces between turns of the film wrapping define a gas flow channel and spaces between adjacent turns of the rib define a plurality of inlet openings in one end plate that communicate with the channel. Each rib has a predetermined width dimension, a predetermined average thickness dimension, and a width-to-thickness aspect ratio of at least 2:1. The spacing between end plates is at least three hundred millimeters (300 mm) and is also greater than the width dimension of a film substrate at a gaseous deposition temperature. The width dimension of each rib is between about 0.5% to about 2.0% of the end plate spacing.
US08523991B2 Ink composition, ink composition for inkjet recording, ink set, ink cartridge, inkjet recording method, and recorded product
An ink composition is provided which does not undergo decomposition or fading of colorants even when stored under high-temperature environment. An ink composition which contains a compound represented by the following general formula (1) and a humectant, wherein the content of the compound represented by the general formula (1) is from 0.1% by mass to less than 7.0% by mass, the content of the humectant having 3 or more hydroxyl groups is 8.0% by mass or less, and the molar ratio of the humectant having 3 or more hydroxyl groups/the compound represented by the general formula (1) being less than 15.0; wherein Ar1 and Ar2 each independently represents an aromatic hydrocarbon ring group, a non-aromatic hydrocarbon ring group, an aromatic heterocyclic group, or a non-aromatic heterocyclic group, A1 and A2 each independently represents a hydrogen atom or a substituent, Y represents —OM or —NR1R2, M represents a hydrogen atom or a metal ion, and R1 and R2 each independently represents a hydrogen atom, an alkyl group, an alkenyl group, an alkynyl group, an aralkyl group, an aryl group, or a heterocyclic group.
US08523988B2 System and method for estimating a mass of particulate matter accumulated in a particulate filter
A particulate estimation system is configured for estimating a mass of particulate matter accumulated in a particulate filter of an exhaust system. The system includes a memory device, an interface, and a controller. The memory device stores a plurality of modules. Each of the plurality of modules is configured to uniquely estimate an amount of the particulate matter accumulated within the particulate filter over a period of time. The interface receives a plurality of input signals. The plurality of input signals correspond to a plurality of modules that are stored in the memory device. The controller derives a hybrid model based on the input signals. The hybrid model is configured to provide an output that is an estimation of the amount of particulate matter accumulated within the particulate filter over the period of time as a function of the plurality of input signals.
US08523987B2 Dust arrester and method for removing dust particles from air
A dust arrester includes a housing with air inlet and air outlet, wherein the ambient air containing dust particles can be introduced into the housing via the air inlet and discharged from the housing via the air outlet. The dust arrester further includes a water trough placed in the bottom of the housing and a chaos effect generator including a nozzle and a material. The nozzle can spray water supplied from the water trough. The water sprayed interacts with the material to generate a chaos condition, so that the dust particles can be removed from the introduced air under the chaos condition.
US08523985B2 Bubble-column vapor mixture condenser
In a bubble-column vapor mixture condenser, a fluid source supplies a carrier-gas stream including a condensable fluid in vapor phase. The condensable fluid in liquid form is contained as a bath in a chamber in each stage of the condenser, and the carrier gas is bubbled through the bath to condense the fluid into the bath. Energy from condensation is recovered to a liquid composition in a conduit that passes through the liquid in the stages of the condenser. The bubble-column vapor mixture condenser can be used, e.g., in a humidification-dehumidification system for purifying a liquid, such as water.
US08523981B2 Hydrophobic ozone-stable membrane made of polyvinylidene fluoride
The invention relates to a hydrophobic, integrally asymmetrical hollow-fiber membrane made of a vinylidene fluoride homopolymer or copolymer, wherein the wall of the membrane has a microporous supporting layer having a sponge-like, open-pored, essentially isotropic pore structure without finger pores, the supporting layer extending across at least 90% of the wall thickness and having pores with an average diameter of less than 0.5 μm. The hollow-fiber membrane is characterized in that it has a separating layer adjacent to the supporting layer on its outer surface and that it has an outer surface with a homogeneous, uniform structure without pores, a porosity in the range from 40 to 80 vol. %, a wall thickness from 25 to 100 μm, a diameter of the lumen of the hollow-fiber membrane from 100 to 500 μm, a permeability for nitrogen of at least 25 ml/(cm2·min·bar), and an elongation at break of at least 250%. The invention further relates to a method for producing hollow-fiber membranes of this type.
US08523979B2 Removal of acid gases by means of an absorbent comprising a stripping aid
A process for removing acid gases from a fluid stream in which a) the fluid stream is treated with an absorption liquid which comprises at least one amine, a stripping aid, and water, wherein the stripping aid is selected from water-miscible liquids, the boiling temperature of which at atmospheric pressure is lower than that of water, b) the treated fluid stream is treated with a liquid aqueous phase in order to convert entrained stripping aid at least in part to the aqueous phase, c) the loaded aqueous phase is heated in order to expel the stripping aid at least in part, and d) the regenerated aqueous phase is cooled and at least in part recycled to step b). The stripping aid promotes the regeneration of the absorbent by stripping. Emissions of the stripping aid via the treated fluid stream are avoided by the treated fluid stream being scrubbed with a liquid aqueous phase.
US08523977B2 Method of desulfurizing steel
A method of desulfurizing steel including steps of forming a slag over a molten metal, drawing a vacuum to less than 5 torr over the slag and molten metal, stirring the molten metal and slag, and deoxidizing and desulfurizing the molten metal and slag to degas the steel reducing at least sulfur, nitrogen, oxygen, and hydrogen contents, and reducing activity of oxygen in the molten metal to less than 30 ppm. The method includes forming a slag composition after degassing the steel comprising CaO between about 50 and 70% by weight, SiO2 between about 20 and 28% by weight, CaF2 between about 5 and 15% by weight, MgO not more than 8% by weight, Al2O3 not more than 1% by weight, and a combination of FeO+MnO not more than 2% by weight, where the sum of CaO+CaF2+SiO2+MgO is at least 85% by weight.
US08523975B2 Salts of mineral nutrients stabilized with amino acids and/or ammonium salt, products and food supplements that contain them and procedures for obtaining same
Salts of mineral nutrients stabilized with amino acids and/or ammonium salt, product and food supplement in which they are included and procedures of obtention, where the salts are obtained with anions of organic acids or inorganic anions and metallic cations associated with amino acids and/or ammonium salt, in which the invention introduces its general structure: {[Ac]n−·Men+←n[Amino acid and/or ammonium salt]}·xH2O Where ← represents a covalent dative bond,These new compounds have better taste and more solubility in water, making them more bioavailable.
US08523973B2 Filter element for fluid filtration, in particular for intake air of internal combustion engines
A filter element (1) for fluid filtration has a hollow-cylindrical filter medium (2) folded in a star shape, an outlet-side end plate (3) and a second end plate (4), a hollow-cylindrical supporting mesh (5) disposed in the interior (6) of the filter medium, wherein at the outlet-side end of the filter element, the supporting mesh has a connecting region (11) in which the supporting mesh (5) is provided with a coupling element (7). In the connecting region (7) the supporting mesh (5) includes a radially outwardly projecting collar (8) protruding beyond the outlet-side end face (9) of the filter medium. The outlet-side end plate (3) encloses the outlet-side end face (9) of the filter medium (2) and the collar (8) and has an annular axial seal (10).
US08523971B2 Multilayer nanofiber filter
A method of making a multilayer filter and the multilayer filter made by the method. The method includes generally two steps. The first step is to coat a layer of nanofibers on a single side or both sides of a substrate medium to obtain a composite filter medium, and the second step is to fold the composite filter medium in a serpentine fashion to form a multilayer filter. The second step may alternatively be accomplished by stacking up a number of sheets of the composite filter medium to form a multilayer filter having a structure of two layers of nanofibers being sandwiched between two layers of said substrate medium. The resulting multilayer filter produced by either method contains at least one structural unit which has two layers of nanofibers being sandwiched between two layers of the substrate medium.
US08523968B2 Abrasive article with improved packing density and mechanical properties and method of making
A bonded abrasive article including a plurality of abrasive grains and an organic bond material, and a method for making said bonded abrasive article, are described herein. The abrasive article has a non-reinforced yield strength of at least about 28 MPa. An abrasive mix is also described herein, including abrasive grains, a bond material and an agglomeration inhibitor. The abrasive mix has a loose bond content that is less than approximately 9.9 %.
US08523967B2 Liquid resin composition for abrasive articles
The invention relates to a liquid resin composition intended for manufacturing abrasives that comprises at least one novolac resin having a glass transition temperature less than or equal to 60° C., at least one reactive diluent and optionally at least one crosslinking agent. Application of the resin composition for producing abrasive articles, especially bonded abrasives and coated abrasives. It also relates to the abrasive articles comprising abrasive grains connected by such a liquid resin composition.
US08523964B2 Hydrogen generating device as well as fuel cell power generating device, electric automobile, sumbergible ship and hydrogen supply system using the same
A hydrogen generating device for generating a gas containing hydrogen by decomposing a fuel containing an organic compound which includes a partition membrane, a fuel electrode provided on one surface of the partition membrane, a fuel supply unit supplying a fuel containing organic compound and water to the fuel electrode, an oxidizing electrode provided on the other surface of the partition membrane, an oxidizing agent supply unit supplying an oxidizing agent to the oxidizing electrode, and a gas generating and collecting unit generating and collecting the gas containing hydrogen from the fuel electrode. A low oxidizing agent supply region where supply of the oxidizing agent is substantially lower than the other region is present on an oxidizing electrode side of the hydrogen generating device.
US08523962B2 Engineered fuel feed stock
Disclosed are novel engineered fuel feed stocks, feed stocks produced by the described processes, and methods of making the fuel feed stocks. Components derived from processed MSW waste streams can be used to make such feed stocks which are substantially free of glass, metals, grit and noncombustibles. These feed stocks are useful for a variety of purposes including as gasification and combustion fuels.
US08523960B2 Stable alkoxylated fatty acid alkyl esters from transesterification-alkoxylation of vegetable oils
Alkoxylated fatty acid alkyl esters are produced from a bio-component feed, preferably containing triglycerides. The triglycerides can be reacted with an alcohol in the presence of an acidic catalyst to form alkoxylated fatty acid alkyl esters, which can provide improved low temperature properties and/or improved oxidative stability in petrochemical products, relative to non-alkoxylated versions of the fatty acid alkyl esters.
US08523944B2 Methods and apparatus for vertebral body distraction and fusion employing flexure members
Improved methods and apparatuses for vertebral body distraction and fusion in accordance with various embodiments of the present invention employ flexure members. Flexure members connect a plurality of structural members to end plates on one end and blocks on another end. Upon insertion into the disc space, a drive screw or similar mechanism can be actuated to drive expansion blocks closer together, which causes flexure members to deflect, resulting in expansion of the structural members and distraction of the end plates. The distracted device can then remain in the body and be used for vertebral body fusion.
US08523941B2 Instrument for inserting intraocular lens
An intraocular lens insertion instrument capable of smoothly pushing out a preset lens is provided. An intraocular lens insertion instrument comprises: a main body including a lens setting section on which a lens is set, a transition section that deforms the lens, and a nozzle piece that releases the lens; and a lens push-out mechanism that pushes out the lens set on the lens setting section. The instrument further includes a releasing means for releasing the lens pushed by the lens push-out mechanism from the lens setting section. The releasing means has a posture holding mount that holds the lens with a forward tilt relative to an axial line of lens movement. The posture holding mount has a passage through which the lens push-out mechanism passes.
US08523940B2 Annuloplasty ring with anchors fixed by curing polymer
Annuloplasty rings and methods for inserting annuloplasty rings are herein disclosed. The annuloplasty ring has a ring shell and a plurality of anchoring fasteners for anchoring the ring shell to adjacent heart tissue. To maintain the shape of the annuloplasty ring upon attachment of the ring to the patient's heart, a hardening polymer is inserted into the ring shell, which is permitted to cure, thereby providing support for the annuloplasty ring and the patient's heart valve.
US08523938B2 Stent
A stent includes a stent body in which struts are joined mutually while intersecting and which is formed tubularly as a whole, and a drug coat layer on the outer surface of the struts. The strut has a bend which is deformed as the stent body expands/contracts in the radial direction, and the drug coat layer with which the bend is coated is formed in such a manner that the drug coat layer is mountain-shaped in a cross-section perpendicular to the axis of the strut and the ridgeline of the mountain shape extends in a wavy shape along the longitudinal direction of the strut. The drug coat layer deforms relatively easily without using plasticizer as the stent deforms and is not so susceptible to causing problems such as peeling, destruction, damage or falling off of the drug coat later.
US08523937B2 Controlled drug delivery using a zein layer modified with levulinic acid
The disclosure relates to medical devices coated with zein admixed with levulinic acid. The medical device may further include a therapeutic agent in contact with zein admixed with levulinic acid. Zein admixed with levulinic acid allows the therapeutic agent to be retained on the device during delivery and also controls the elution rate of the therapeutic agent following implantation. The disclosure further relates to methods of delivering a therapeutic agent on said medical devices as well as their use especially in the form of stents for prevention of restenosis.
US08523936B2 Expandable slide and lock stent
An expandable slide and lock stent comprises a tubular member that can be expanded from a collapsed state to an expanded state. The tubular member can comprise a reversing helical backbone and at least one rail member extending from the helical backbone in a circumferential direction. The backbone can have at least one engagement element that can be configured to receive a rail member to form the tubular member. In some embodiments, the reversing helical backbone can comprise a plurality of discrete segments having a variable profile and/or wave form.
US08523930B2 Methods and devices for cooling spinal tissue
Methods, systems, and devices are disclosed for cooling tissue, and in particular for applying therapeutic hypothermia to the spinal canal, tissue disposed within the spinal canal, and nerve roots extending from the spinal canal. Bone screws, intervertebral implants, stabilization rods, spinous process spacers, and other devices are described which define a chamber through which a chilled fluid, expandable gas, or other coolant means can be circulated, delivered, or activated to cool adjacent tissue. The degree of cooling can be regulated using a controller, which can be configured to increase or decrease the cooling effect based on any of a variety of measured or predicted physiological or thermodynamic properties. Methods are disclosed for implanting cooling instruments and for carrying out various treatment regimens that involve cooling tissue using such instruments.
US08523929B2 Devices and methods for controlling patient temperature
Relatively non-invasive devices and methods for heating or cooling a patient's body are disclosed. Devices and methods for treating ischemic conditions by inducing therapeutic hypothermia are disclosed. Devices and methods for inducing therapeutic hypothermia through esophageal cooling are disclosed. Devices and methods for operative temperature management are disclosed.
US08523927B2 System for treating lipid-rich regions
A system is described for removing heat from a subject's subcutaneous lipid-rich regions, such as tissues, organs, cells, and so forth. In various embodiments, the system includes a controller, a computing device, a data acquisition device, a chiller, and one or more applicators. The system can employ these components to receive a selection of a treatment profile and apply the selected treatment using an applicator. The treatment profile may be received from a patient protection device that connects to an applicator.
US08523918B2 Therapy to adjacent motion segments
Disclosed are methods and apparatus for the provision of spinal therapy to three or more adjacent motion segments accessed through a trans-sacral approach. The spinal therapies include fusion and dynamic stabilization with and without a distraction of the most cephalad motion segment of the two or more adjacent motion segments provided therapy. The disclosure includes methods and apparatus to impart a distraction on a second more caudal motion segment after providing therapy to the more cephalad motion segment.
US08523916B2 Methods and devices for spinal fixation element placement
Minimally invasive methods and devices are provided for positioning a spinal fixation element in relation to adjacent spinal anchors. In an exemplary embodiment, the device is a percutaneous access device that can be coupled to a spinal anchor, and the method includes the step of positioning a spinal fixation element through at least one sidewall opening of at least two percutaneous access devices such that the spinal fixation element extends in a lengthwise orientation that is substantially transverse to the longitudinal axis of each percutaneous access device. The spinal fixation element can then be advanced in the lengthwise orientation to seat the spinal fixation element in or adjacent to the receiver heads of at least two adjacent spinal anchors. A fastening element or other closure mechanism can then be applied to each spinal anchor to engage the spinal fixation element within the receiver heads of the adjacent anchors.
US08523915B2 Friction set screw for use with spinal implant systems
A set screw for use in association with spinal implant assemblies. The set screw includes a threaded base portion extending along a longitudinal axis and formed of a first material, and a friction member extending from a distal end of the threaded base portion and formed of a second material different from the first material. In one embodiment, the spinal implant assembly includes a connector member having a passage and an opening in communication with the passage, and an elongate support member positioned within the passage of the connector member. The set screw is threadedly engaged to the connector member and at least partially positioned within the opening, with a distal end portion of the friction member extending into the passage and compressed against an outer surface of the elongate support member to inhibit movement of the elongate support member within the passage.
US08523913B2 Helical guide and advancement flange with break-off extensions
A spinal fixation device combines an open-headed anchor member, such as a bone screw or a hook with spaced apart arms forming a rod receiving channel. The arms have break-off arm extensions that are broken-off or separated after the rod is clamped. The closure and inner surfaces of the arms and tabs have mating helical anti-splay guide and advancement flanges formed thereon which radially interlock and mechanically cooperate to prevent splaying the arms and extensions as the closure is advanced into the rod receiving channel.
US08523907B2 Prostheses, tools and methods for replacement of natural facet joints with artificial facet joint surfaces
Cephalad and caudal vertebral facet joint prostheses and methods of use are provided. The cephalad prostheses are adapted and configured to be attached to a lamina portion of a vertebra without blocking a pedicle portion of the cephalad vertebra. In some embodiments, the prosthesis is attached with a non-invasive support member, such as a clamp. In other embodiments, a translaminar screw may be used for additional fixation.
US08523905B2 Intervertebral stabilization system
An intervertebral stabilization system for at least three vertebrae comprising pedicle screws attachable to the vertebrae; at least one rod for the connection of at least two pedicle screws to form a rigid stiffening system; and at least one band which is capable of being pre-stressed in tension and which is surrounded in the implanted state of the stabilization system by at least one compressible pressure member arranged between two adjacent pedicle screws for the connection of the pedicle screws to form an elastic support system, wherein a common pedicle screw is associated both with the stiffening system and with the support system and the band can be connected or is connected to the rod by means of a band attachment.
US08523902B2 System and method for attaching soft tissue to bone
Disclosed herein are methods and devices for securing soft tissue to a rigid material such as bone. A bone anchor is described that includes an anchor body with expandable tines and a spreader that expands the tines into bone. Also disclosed is a bone anchor that includes a base and a top such that suture material may be attached to apertures in the anchor top or else compressed between surfaces on the base and top to secure the suture to the anchor. Methods are described that allow use of single bone anchor to secure tissue to bone or also to use more than one bone anchor to provide multiple lengths of suture material to compress a large area of soft tissue against bone.
US08523894B2 System for withdrawing body fluid
The present invention relates to a compression device for stimulating the efflux of a body fluid from a body part. The device has a compression unit with a pressure-application region made of a deformable material, the region being formed to generate a repulsive force between the body part and the compression unit. The repulsive force passes through a force maximum then decreases to serve as an indication that the body part is guided sufficiently firmly and far enough onto the compression unit.
US08523890B2 Bipolar or ultrasonic surgical device
An electro-mechanical surgical device, system and/or method may include a housing, at least two opposing jaw, and at least one electrical contact associated with at least one of the jaws. The electrical contact may include at least one of a bipolar electrical contact and an ultrasonic electrical contact. The electrical contact may be a row of electrodes located on one or all of the jaws. A sensor may also be associated with any tissue located between the jaws to sense and report the temperature of that tissue. A piercable ampulla containing fluid may also be placed on at least one of the jaws so that the fluid is releasable when the jaws are in closed position and the electrode(s) pass through the tissue into the piercable ampulla.
US08523885B2 Implantable restriction system with load monitor
An apparatus for regulating the functioning of a patient's organ or duct includes an elongated member having a first end and a second end. A fastener is disposed on the first end of the elongated member. The fastener is configured to engage the second end of the elongated member so that the elongated member forms a loop around the organ or duct. A tension element is disposed for movement within the elongated member. A drive element is associated with and engages the tension element for causing the tension element to control the tension applied by the elongated member against a patient's body organ or duct. A load monitor ensures that excessive pressure is not applied to a patient's body organ or duct.
US08523875B2 Graft caliper marking device
A graft caliper provides for a first member having a first pick at its distal end and its proximal end attached to a handle. A second member of the graft caliper is disposed above the first member and has a second pick at its distal end that extends beyond the first pick. The proximal end of the second member is attached to an adjuster which causes the second member to move from a first position to a second position in order to change a distance the second pick extends beyond the first pick. The graft caliper provides for an indication of at least one metric for describing the distance the second pick extends beyond the first pick and places an identifier on a surface of bone representing the location of a tunnel to be formed through a femur, tibia or any other anatomical structure.
US08523862B2 Bone plate aiming block
A drill guide system for a bone plate having holes includes a guide block having at least two drill guide bores alignable with a bone screw receiving hole in a bone plate. A locking element extending through at least one drill guide block bore into the bone plate bone screw receiving hole, the locking element having a partially threaded bore portion and having a bifurcated tip surrounding the threaded bore portion. The bifurcated tip capable of engaging an inwardly extending protrusion formed on an internal wall of a bone screw receiving hole in the bone plate. An axially moveable threaded rod has a head for contacting an outer surface of the guide block and an end portion engaging a portion of the bore in the bifurcated tip of the locking element for separating sections of the bifurcated tip on axial movement of the rod prior to the head contacting the second surface of the drill guide block.
US08523861B2 Method and apparatus for osteosynthesis
A proximal humeral plate assembly can include a first plate, a coupler, a second plate, and a guide. The first plate can define a window and can have a first major surface adapted to conform to a native bone structure. The coupler can be formed on a second major surface of the first plate opposite the first major surface. The second plate can be adapted to engage the coupler, to cover the window, and to conform to the native bone structure. The second plate can include through holes adapted to receive bone screws. The guide can be adapted to engage the coupler and to guide at least one of a cutting tool and a dilation tool.
US08523857B2 Method of treating tissue with radio frequency vascular electrode array
A method of treating a patient is provided. The method comprises delivering an electrically conductive material within a vascular network, wherein the electrically conductive material embolizes in a region of the vascular network to form a vascular electrode array that assumes a geometry of the embolized region of the vascular network. The method may optionally comprise delivering a containment agent within the vascular network proximal to the delivered electrically conductive material to stabilize the vascular electrode array. The method further comprises applying electrical energy (e.g., radio frequency (RF) energy) to the vascular electrode array to therapeutically conduct electrical energy into a region of the targeted tissue adjacent the embolized region of the vascular network.
US08523855B2 Circuit for controlling arc energy from an electrosurgical generator
A circuit is disclosed which minimizes the amount of tissue vaporized during a first half (positive half cycle) of an electrosurgical current cycle and minimizes the amount of current applied to tissue during a second half (negative half cycle) of the electrosurgical current cycle to control thermal spread. The circuit is preferably provided within an electrosurgical generator which is capable of controlling the amount of energy delivered to a patient during electrosurgery on a per arc basis. Also, a method of controlling arc energy via the circuit is disclosed. The method includes the steps of generating a current via a generating unit and dividing the current into two paths via a diode-resistor block, one path including one of a resistor and a potentiometer in series with a pair of electrical components, wherein arc energy variations produced by the generating unit are controlled by the diode-resistor block.
US08523853B2 Hybrid contact quality monitoring return electrode
An electrosurgical return electrode is disclosed. The return electrode includes an intermediary layer formed from a dielectric material, the intermediary layer having a top surface and a patient-contacting surface. The return electrode also includes a capacitive return electrode formed from a conductive material disposed on the top surface of the intermediary layer and a resistive monitoring electrode formed from a conductive material disposed on the patient-contact surface of the intermediary layer.
US08523852B2 Thermally adjustable surgical tool system
A power source delivers oscillating electrical energy to an electrical conductor, such as a wire or catheter, which is coated circumferentially with a ferromagnetic material in a selected region. With high frequency electrical energy, the ferromagnetic material has a quick response in heating and cooling adjustable by the controllable power delivery. The ferromagnetic material can be used for separating tissue, coagulation, tissue destruction or achieving other desired tissue effects in numerous surgical procedures.
US08523850B2 Method for heating a surgical implement
A power source delivers oscillating electrical energy to an electrical conductor, such as a wire or catheter, which is coated circumferentially with a ferromagnetic material in a selected region. With high frequency electrical energy, the ferromagnetic material has a quick response in heating and cooling adjustable by the controllable power delivery. The ferromagnetic material can be used for separating tissue, coagulation, tissue destruction or achieving other desired tissue effects in numerous surgical procedures.
US08523846B2 Corneal surgery apparatus
A corneal surgery apparatus which comprises a laser irradiation optical system and an eye position change detection unit comprising an illumination optical system and an image pick-up camera picking up an anterior-segment image of a patient's eye and detecting the change in eye position based on an iris pattern in the image, and is arranged such that an irradiation position tracks movement of the eye to ablate a cornea, wherein the apparatus further comprises a contrast adjustment unit extracting a pupil portion and an iris portion based on luminance information of the image, and increasing/decreasing a set value of an illumination light amount and/or a set value of a gain of the camera to increase a contrast of the pupil portion to the iris portion and/or a contrast of the iris pattern within a range that luminance at the iris portion is not saturated.
US08523845B2 Method for operating a surgical power tool
A surgical power tool has an actuation assembly which comprises a force sensor and a switch. The force sensor is provided to determine an actuation force produced by the user, and the switch is transferred by the actuation force from a first switching state to a second switching state. A combined evaluation of the force sensor signal and of the switching state enables, for example, a plausibility check for increasing the operational reliability of the power tool.
US08523843B2 Vapor hydrated catheter assembly and method of making same
A catheter assembly and method is disclosed which comprises a catheter having a coating on at least a part of its length intended to produce a low-friction surface on the catheter when treated with an activating substance in the form of a vapor. The catheter assembly also includes a catheter package forming an interior space divided by a gas permeable, liquid impermeable barrier into a first cavity and a second cavity. The first cavity of the catheter package accommodates the catheter therein and the second cavity accommodates at least a quantity of liquid in its liquid phase therein. The liquid in the second cavity can change phase into a vapor capable of passing from the second cavity, through the barrier, and into the first cavity where the vapor can activate the coating. As a result, the vapor produced when the liquid changes phase causes the coating on the catheter to be activated to thereby produce the low-friction surface on the catheter so it is ready-to-use when it reaches the end user.
US08523842B2 Dual-lumen catheter with contrastradiography sections to identify the lumens
A catheter has an outer peripheral portion (15) in the form of a tube and an internal wall (16, 26) within the tube forming a plurality of lumens (11a, 11b, 21a, 21b). Axially extending linear contrastradiography sections (17a, 17b, 27a, 27b) of radiopaque material are formed at a plurality of intersection points between the outer peripheral section and the wall, the peripheral extent (a, b) of the respective contrastradiography sections being different.
US08523841B2 Catheter with spiral slit terminating in slit termination portion oriented to suppress crack occurrence
A catheter comprising a sheath to be inserted into a living body, wherein the sheath includes a tubular reinforcement layer of at least one layer, which is formed with a spiral slit continuous from the distal side to the proximal side thereof; a termination end of the spiral slit is provided on the proximal side of the slit proximal portion at the site of the proximal side of the spiral slit; and at the same time, there is formed a slit termination portion in which inclination angle of the spiral slit with respect to the circumferential direction of the reinforcement layer is larger than that of the slit proximal portion.
US08523839B2 System and method for pumping intravenous fluid
An intravenous fluid pump (IV) contains a disposable part including a fluid chamber having a resilient top membrane and a non-disposable part including a piston abutting a resilient membrane and a vacuum chamber fitted on top of the resilient top membrane. An external pump is used to create vacuum in the vacuum chamber, resulting in the resilient top membrane being held taut. The flow rate through the pump is relatively independent of changes in the pressure of IV fluid on the upstream and the downstream due to changes in the relative elevation of the fluid reservoir and the patient with respect to the fluid pump.
US08523838B2 Connector device
The present invention relates to a connector device to connect a first and a second fluid container, directly or indirectly. The connector device exhibit a first and a second connection means, a pierceable barrier member, a piercing member, a fluid transfer channel and a pressure normalization channel. The pressure normalization channel is arranged to normalize an increasing pressure inside second fluid container. A valve arrangement permitting fluid to flow in a first and a second direction is arranged in the pressure normalization channel. The valve arrangement exhibit a cracking pressure in at least the first direction. The present invention provides for a connector device which reduces the risk of clogging the barrier filter.
US08523836B2 Disposable absorbent article with finger tab
An absorbent includes inner and outer surfaces, an absorbent body disposed therebetween, and front waist, back waist, and crotch regions. The article also includes pairs of front and back side panels, each side panel having an attachment edge and a free edge, the front and back side panels being releasably attachable to define a wear configuration of the absorbent article. The article also includes a finger tab having a distal end, a tab line where the finger tab intersects the free edge, and a proximal end attached to the free edge, wherein the distal end has a distal end longitudinal midpoint, wherein the tab line has a tab line longitudinal midpoint, and wherein the distal end longitudinal midpoint is longitudinally offset from the tab line longitudinal midpoint.
US08523830B2 Disinfecting caps for medical female luer connectors
Caps can be used to cover and disinfect a male protrusion portion of a medical connector. Some caps can create a seal with the male protrusion to prevent antiseptic from entering a lumen the protrusion. A biasing element can aid in creating or maintaining the seal.
US08523829B2 Intravenous delivery system
An intravenous system includes an assembly for coupling a solution container to a delivery system drip chamber used for regulating the flow rate of solution in a patient intravenous line. In one embodiment, the solution delivery system includes a drip chamber having an opening formed in a side wall, and a vent plug disposed in the opening for providing a self-priming function to the IV system. A termination end of the patient intravenous line includes an end cap with a vent and a seal for allowing air in the intravenous line to escape through the end cap while preventing leakage of solution from the termination end.
US08523824B2 Guidewire and catheter management device
Provided are devices and methods for catheter and guidewire management in a surgical setting. In one implementation, the device includes a housing having a curved bottom surface for accommodating the shape of a patient's leg. A retaining member is included, which can retain one or more guidewires, catheters, or the like. In another embodiment, the housing may include a number of vertical supports between which are mounted at least one retaining member housing. The retaining member housing may in turn house a retaining member, suitable for receiving and retaining one or more elongated devices such as catheters or guidewires. The retaining member may have a suitable size, shape, and level of flexibility to allow a catheter or guidewire to be placed therein and held with a desired level of force until such a time as a user desires to remove the catheter or guidewire.
US08523814B2 Self-venting cannula assembly
The present disclosure relates to a self-venting cannula assembly. The self-venting cannula assembly including an outer tube that defines a throughbore, an inner tube, a vent aperture, and a filter element. The inner tube is positioned within the outer tube, which defines a vent channel therebetween. The vent aperture is formed in the outer tube to provide fluid communication between the vent channel and an external environment. The filter element is positioned over the vent aperture and prevents particles having a dimension greater than about 0.2 microns from passing therethrough.
US08523813B2 Injector auto purge
An auto purge for an intravenous contrast injector of the type having a motor which advances a plunger drive ram and configured for use with a pre-filled or user-filled syringe containing an approximate known amount of air including a processor which causes the motor to move and a memory storing a predetermined purge stop point representative of the approximate known amount of air in the syringe, the injector configured to automatically advance the plunger drive ram an amount substantially equal to the predetermined purge stop point representative of the approximate known amount of air contained in the syringe.
US08523812B2 Method of controlling a surgical system based on a rate of change of an operating parameter
A surgical system that is able to sense the onset of an occlusion or other surgical event as well as when an occlusion breaks. To help avoid overheating of the tip, the system of the present invention predicts the temperature of the eye using irrigation flow rate and reduces the power to the handpiece automatically if an overheating situation is predicted. Alternatively or in addition, the system of the present invention monitors the power drawn by the handpiece, which is indicative of the cutting load on the tip, and automatically adjusts the power or stroke of the tip to compensate for increased loads on the tip.
US08523811B2 Stretch resistant therapeutic device
A vasoocclusive coil is reinforced with a stretch resistant member to improve safety during retraction of the coil. The stretch resistant member is fixedly attached at one end to the vasoocclusive coil, and the other end of the stretch resistant member is detachably mounted to an elongated pusher member to allow for placement and release of the vasoocclusive coil within the patient's vasculature.
US08523810B2 Single-use pneumatic safety syringe providing gas-driven needle retraction
A pneumatic retractable syringe has a plunger having an interior retraction lumen. The plunger and syringe barrel have cooperating locking elements so that the plunger is locked after use within the syringe barrel. After injection of medicament is completed, the needle is retracted into the lumen by compressed gas that is released from a gas cell within the syringe when the gas cell is ruptured just before the plunger reaches the end of its downstream path of travel.
US08523806B2 Sprayer
A sprayer is capable of inhibiting or preventing clogging occurring in a nozzle upon ejection of a liquid through the nozzle. A sprayer includes liquid supply for separately supplying a first liquid and a second liquid different in liquid composition, and a nozzle. The nozzle includes a first flow path and a second flow path along which passes the first liquid and the second liquid supplied from the liquid supply. In addition, the nozzle includes a third flow path along which passes a gas. A merge part is provided at which the first flow path and the second flow path merge at their respective halfway parts. A vent is provided at the merge part for allowing the gas which has passed through the third flow path to flow into the merge part.
US08523799B2 Method for priming a blood line set
A method for priming a blood tubing set having a venous line and an arterial line whose connections at the patient side are in communication with two separate inlets of a chamber of, in particular, a bag and whose connections at the machine side are in communication with a dialyzer. The method includes the steps of parallel filling of both the venous and the arterial lines via a feed line so that priming liquid flows through both inlets into the chamber; and circulation of the priming liquid in the circuit of the lines, the dialyzer and the chamber via a pump so that one of the inlets of the chamber acts as an inlet and the other as an outlet.
US08523797B2 Automated point-of-care fluid testing device and method of using the same
A point of care fluid testing system for determining properties of a fluid comprises a patient connection, a primary fluid routing portion, a pump, a secondary fluid routing portion, and a flushing fluid connection. The patient connection connects the system to a patient. The primary fluid routing portion has a pump region, a fluid transfer region, and an in-line testing region. The pump region pumps the fluid sample from the patient to the testing portion and back to the patient. The in-line testing region evaluates a first characteristic of the fluid sample. The fluid transfer region transmits a portion of the fluid sample out of the primary fluid routing portion. The secondary fluid routing portion includes an off-line testing portion that receives the portion of the fluid sample transmitted from the fluid transfer region. The off-line testing portion evaluates a second characteristic of the fluid sample.
US08523792B2 Rehabilitative training devices for use by stroke patients
According to one embodiment, a rehabilitative training device for use with a stroke patient includes a first component that is operatively coupled to a first body part (unaffected body part) of the patient and a second component that is operatively coupled to a second body part (affected body part) of the patient. The first component and second component are operatively coupled to one another such that motion of the first component as a result of movement of the first body part by the user causes the second component and second body part to move in a symmetrical motion.
US08523791B2 Multi-modal drug delivery system
A device for the transdermal delivery of a therapeutic agent at a treatment site comprising a housing containing: a mechanical vibration element; a light source; a heating and/or cooling element; a power source for powering said mechanical vibrational element, light source, and heating element; and an electronic control module.
US08523788B2 Device, system and method for examining a body lumen
An in-vivo examining device, system and method for identifying the presence of strictures in the small bowel are provided. The in-vivo examining device includes a monitoring mechanism that becomes deactivated when exposed to in-vivo substances native to the small bowel or the colon, and a degradable device body that includes at least a first body portion which degrades at a slow rate when exposed to in-vivo substances native to the small bowel and at a fast rate when exposed to in-vivo substances native to the colon. The degradation of the degradable device body exposes the monitoring mechanism to substances native to the small bowel or the colon and thus indicates whether the examining device has safely passed through the small bowel or whether it is retained in the small bowel due to strictures in the small bowel.
US08523787B2 Detection of tenting
A method, including measuring a force exerted by a probe on tissue of a patient and measuring a displacement of the probe while measuring the force. The method further includes detecting a tenting of the tissue responsively to a relation between the measured force and the measured displacement.
US08523785B2 Method and apparatus for measuring analytes
A method for measuring the concentration of a compound in the blood of a part of a subject is provided. An invasive or non-invasive sample of blood may be used for this determination. Also provided is a device for measuring the concentration of a compound in the blood of a subject. The device comprises a source of electromagnetic radiation, a holder, a detector and a processing system.
US08523782B2 Minimally invasive determination of collateral ventilation in lungs
Minimally invasive methods, systems and devices are provided for assessing collateral ventilation in the lungs. In particular, collateral ventilation of a target compartment within a lung of a patient is assessed by advancement of a catheter through the tracheobronchial tree to a feeding airway of the target compartment. The feeding airway is occluded by the catheter and the opening and closing of a one-way valve coupled with the catheter is observed. If the valve ceases opening and closing over time, this may indicate that significant collateral ventilation into the target compartment is absent. If the valve continues to open and close over time, significant collateral ventilation into the compartment may be present. Based on the collateral ventilation assessment, a treatment plan may be generated.
US08523780B2 Electronic device and system for detecting rejection in transplant recipients
The current invention relates to an implantable device, system, method, and computer readable medium comprising computer executable components for detection of rejection of a cardiac allograft. Acute rejection and chronic rejection are the leading cause of death in heart transplant recipients post transplant. The current invention seeks to address this problem by providing methods, devices, systems and computer readable media comprising computer executable components to monitor the efficacy of immunosuppressant therapy and evaluate the degree of rejection in a cardiac allograft. To provide this functionality, an implantable device comprises sensors which measure physiologic parameters at specified intervals after the transplant procedure. These measured parameters are subsequently compared with baseline parameter data to detect rejection of the cardiac allograft.
US08523774B2 Fresnel-based beamforming for ultrasonic arrays
An ultrasonic beamformer may include an input signal line for each ultrasonic transducer element configured to carry a broadband pulse from the ultrasonic element. The ultrasonic beamformer may include a number of signal shifters that is substantially less than the number of transducer elements. Each signal shifter may be configured to shift a broadband pulse in a way that is different from the way the other signal shifters are configured to shift a broadband pulse. For each of the input signal lines, a multiplexer may be configured to electrically connect the broadband pulse received on the input signal line to a selected one of the signal shifters. A multiplexer controller may be configured to generate the control signal for each of the multiplexers in a fashion that causes the ultrasonic beamformer to substantially compensate for the differences in the distances. A comparable configuration may be used for transmission.
US08523773B2 Long term analyte sensor array
A long term analyte sensor for measuring at least one analyte in the body of a user and which includes a housing, a plurality of analyte contacting sensor elements and at least one structure for relaying information away from the sensor. This plurality of analyte contacting sensor elements are typically disposed in an array. The analyte sensor further includes at least one sensor protection membrane that is controllable in a manner such that sensor elements may be activated (e.g. exposed to the external environment) at different times so as to extend the useful life of the sensor. In illustrative analyte sensors, the analyte is glucose.
US08523769B2 Spreader for aortic valve reconstruction
A spreader for aortic valve reconstruction having a dimensionally stable ring and three retractor arms comprising, respectively, a stem and a blade, with the blade being distally disposed on the stem, and wherein the retractor arms are disposed, offset relative to each other by respectively 120° in the direction of circumference of the ring, on said ring, and wherein the stems of the retractor arms are substantially aligned as perpendicular relative to the plane of the ring, and wherein the retractor arms are supported on the ring in such a way by the proximal end of their stems that they can be radially moved relative to each other toward the inside and radially expanded by the spring force of the ring.
US08523762B2 Endoscope system, endoscope, supporting member, and method of using endoscope system
An endoscope system includes: an endoscope including an elongated insertion portion provided with a bendable bending portion, the insertion portion being inserted into a duodenum; and a first balloon to a fourth balloon for moving a one-side surface of a distal end portion located nearer to a distal end side than the bending portion in the insertion portion in parallel with respect to a field of view direction S of an objective lens which is a diameter direction of the insertion portion, separately from bending of the bending portion, the one-side surface being located in a circumferential direction along an insertion direction W of the insertion portion and parallel to a central axis P of the insertion portion.
US08523761B2 Penile prosthetic reservoir
An implantable penile prosthetic includes a pump attachable between a reservoir and a cylinder that is implantable into a corpora cavernosum of a penis. The reservoir has a central longitudinal axis and includes a wall connected between a first edge of a first surface and a second edge of a second surface. The first surface is concave relative to the first edge and the second surface is concave relative to the second edge such that each of the first and second surfaces form a depression in the reservoir when the reservoir is empty of liquid. The reservoir expands to contain liquid such that the first surface and the second surface are both convex relative to the central longitudinal axis.
US08523754B2 Multi-polar magnetic devices for treating patients and methods therefor
A system for treating patients includes a first magnetic device including a set of four magnetic discs arranged in a square array, the four magnetic discs including two having negative magnetic poles lying in a first plane and two having positive magnetic poles lying in the first plane, wherein the two magnetic discs having negative magnetic poles extend along a first diagonal line and the two magnetic discs having positive magnetic poles extend along a second diagonal line that crosses the first diagonal line, and a housing containing the four magnetic discs for maintaining the magnetic discs in the square array arrangement, the housing including an alignment marker for aligning the first magnetic device on a patient.
US08523748B2 Charging member and process for its production
A charging member is provided which has a surface layer that can more surely keep bleeding from occurring. It is a charging member having a substrate, an elastic layer and a surface layer; the surface layer containing a high-molecular compound having a constituent unit represented by the following formula (1) and a constituent unit represented by the following formula (2), and having an Si—O—Zr linkage.
US08523737B1 All-wheel-drive disconnect clutch control
A method for controlling a vehicle drivetrain includes de-energizing a clutch that connects a differential output to a wheel, rotating said component through a sump by pulsing the clutch when a speed of a differential component is less than a reference speed, and cyclically pulsing the clutch while a speed of said component exceeds the reference speed and a count of a timer, started when the clutch is de-energized, exceeds a reference count.
US08523734B2 Multi-mode hybrid transmission
A multi-mode hybrid transmission for transmitting power from a prime mover and a stored source of energy to a final drive shaft. The transmission may include an input shaft to receive torque from the prime mover, a countershaft operatively coupled to the final drive shaft, a plurality of gear pairs each defining a torque path from the input shaft to the countershaft, a synchromesh clutch assembly to selectively couple the input shaft with a desired gear pair, and first and second electric machines rotatably carried by the input shaft. The first electric machine can provide a motive force to the final drive shaft and the second electric machine can covert rotary speed of the input shaft into electrical energy. Additionally, the first and second electric machines can provide supplemental torque to the output shaft during periods of reduced torque from the prime mover associated with a change in torque path.
US08523732B2 Double-fly wheel damper with epicyclic gear train
A double shock-absorbing steering wheel, in particular for automobile vehicles, including a primary inertia mass connected to an engine shaft (12), a secondary inertia mass (14) connected by clutch E to a gearbox BV, and a torsion damper (18) rotatably connecting the two inertia masses (10, 14). The torsion damper includes an epicycloidal gear train whose outer crown wheel (22) engages with a spring (28) for absorption of vibrations and rotation acyclisms. The spring is mounted around the crown wheel (22) in a fixed frame (26).
US08523730B2 Planetary gear unit and image forming apparatus including same
A planetary gear unit including a sun gear rotatable by torque from a drive source, an outer gear disposed coaxially with the sun gear, multiple planetary gears disposed within the outer gear at equal intervals along an inner circumference of the outer gear to engage the sun gear and the outer gear, a carrier pin to rotatably support each of the multiple planetary gears, and a carrier rotatable coaxially with the sun gear and the outer gear to support both ends of the carrier pin. At least a first end of the carrier pin is constructed of a circular portion and a linear portion to form a first supported part. The carrier includes a first support part that supports the first supported part and is formed to position the circular portion of the first supported part downstream from the linear portion in a direction of rotation of the carrier.
US08523724B2 Method of synchronizing in split torque continuously variable dual clutch transmission
A method including activating a first clutch assembly to connect a first rotatable member to a rotating final output member until a shift trigger point is reached to provide a rotational speed to the first rotatable member from the final output member. The first clutch assembly is then deactivated. The second clutch assembly that connected a synchronized second rotatable member with the final output member is then deactivated. A third synchronizer engaged with the first rotatable member, and the first clutch assembly is activated to connect the first rotatable member to the final output member.
US08523723B2 Power train for hybrid vehicle
A power train for a hybrid vehicle may include: a first planetary gear set that includes at least four rotary elements; a second planetary gear set that includes at least three rotary elements one of which is connected with at least one of the rotary elements of the first planetary gear set; a first clutch that is configured to connect/disconnect a rotary element of the first planetary gear set with/from a rotary element of the second planetary gear set; and a first brake that is provided to restrain rotation of a rotary element of the second planetary gear set, wherein at least two or more independent power sources and an output element are connected to the rotary elements of the first planetary gear set and the second planetary gear set.
US08523722B2 Pulley for continuously variable transmission
Disclosed is a pulley capable of meeting requirements for both enhancement in friction coefficient, and maintenance of abrasion resistance, required of a belt CVT (continuously variable transmission).The pulley is a pulley of the continuously variable transmission for effecting power transmission between an element and the pulley, being composed of a steel stock containing a predetermined amount of Mn, wherein the surface of the steel stock has a surface-hardened layer of either a nitriding layer or a carbonitriding layer, containing the predetermined amount of Mn, and the surface-hardened layer has properties for stably securing friction coefficient not lower than 0.115, exceeding the friction coefficient of SCr420H steel currently in use, and maintaining abrasion resistance equivalent to the abrasion resistance of the SCr420H steel, or improving the same.
US08523719B1 Helical tensioner for tension members
A tensioner structured to shorten the effective length of a tension member is provided. The tensioner has a body with an outer surface and a generally helical path on the outer surface. The tension member is wrapped around the tensioner body and retained in the path. In this configuration, the tensioner acts to retain a first length of the tension member within a second, shorter length corresponding to the length of the tensioner body. When the effective length of a tension member is reduced, the amount of sag in the tension member is reduced.
US08523718B1 Arrow vane airfoil
Arrow vanes, devices and methods for improving arrow vane airfoils for compound arrows, crossbow arrows and traditional arrows, which improves flight characteristics over traditionally manufactured, configured and/or applied vanes. Compound bends in the base of the vanes can be done by clamping the vanes in a channel having a generally straight portion and a generally bent portion. The bent portion can have a helical right bend or a helical left bend. A fletching jig can be used to glue the compound bent bases of the vanes to sides of an arrow shaft.
US08523716B2 Free-standing post
The invention relates to a free-standing post comprising stabilizer means for stabilizing it on the ground, a non-rigid element for holding an article, which element extends upwards over a height H and has a bottom portion extended by a top portion. First anchor means are arranged between the stabilizer means and the bottom portion. In addition, a flexible longitudinal element is of length greater than the height H of the non-rigid element. Second anchor means are arranged between the bottom end of the flexible longitudinal element and the stabilizer means. Third anchor means are arranged between the top end of the flexible longitudinal element and the top end of the top portion of said non-rigid element. The invention also relates to a sport game set equipped with at least one such free-standing post.
US08523712B2 Training and coordination device
A training and coordination device including a projectile member such as a ball or sack secured to an elastic string is described. The first end of the elastic string is attached to a location and the second end is connected to the projectile member. At least an end portion of the elastic string secure to the projectile member comprises multiple strands of an odd number. The multiple strands of the elastic string in conjunction with the elasticity of the string generate a random motion of the sack when the sack moves relative to the string.
US08523711B2 Personal golfing assistant and method and system for graphically displaying golf related information and for collection, processing and distribution of golf related data
A handheld apparatus for displaying a graphic representation of a golf course. The handheld apparatus including a location measuring device that generates location information corresponding to a location of the handheld apparatus; a memory that stores location information corresponding to each of a plurality of features of the golf course; a computing device connected to the location measuring device and the memory that retrieves a subset of the plurality of features of the golf course based on the measured location information generated by the location measuring device; and a display connected to the computing device that displays a graphic representation of the retrieved subset of the plurality of features of the golf course.
US08523710B2 Golf ball
Golf ball 2 has spherical core 4, cover 6 positioned outside the core 4, mark layer 8 and paint layer 10. The resin composition of the cover 6 includes composite particles. The composite particle has a nucleus and a coat layer. The nucleus is constituted with aluminum oxide. The coat layer is constituted with titanium oxide. The composite particles are flaky. The amount of the composite particles is 0.1 parts by weight or more and 15 parts by weight or less per 100 parts by weight of the base resin of the cover 6. The composite particles may be also dispersed in the paint layer 10. The amount of the composite particles in the paint layer 10 is 1 part by weight or more and 30 parts by weight or less per 100 parts by weight of the base resin of the paint layer 10.
US08523709B2 Golf ball having reduced surface hardness
A golf ball comprising a core and a cover layer disposed about the core, the cover layer comprising a cover inner surface, a cover outer surface, a treated cover region, and an untreated cover region, the treated cover region extending inward from the cover outer surface a depth D.sub.CTr, the untreated cover region disposed between the cover inner surface and the treated cover region and having a depth D.sub.CUTr, the treated cover region comprising a fatty acid and/or fatty acid salt composition, wherein the treated cover region comprises a hardness .alpha. and the untreated cover region comprises n regions of hardness wherein n.gtoreq.1 and wherein at least one of the n regions of hardness has a hardness H.sub.1 that is different than the hardness .alpha., and wherein each of said n regions of hardness further comprise a depth D.sub.CUTn such that D.sub.CTr.ltoreq.(1/n)(D.sub.UT1+D.sub.UT2+ . . . +D.sub.UTn).
US08523708B2 Golf ball having reduced surface hardness
The invention is directed to golf ball comprising a core and a cover disposed about the core, the cover comprising at least one cover layer comprising an cover outer surface and a cover inner surface, the cover outer surface comprising a fatty acid and/or fatty acid salt composition, the cover outer surface further comprising a hardness α and the cover inner surface comprising a hardness β, wherein the hardness α is different than the hardness β. In another embodiment, the at least one cover layer comprises a treated cover region and an untreated cover region, the treated cover region extending inward from the cover outer surface a depth of about 1% or greater of a distance between the cover outer surface and the cover inner surface, and the untreated cover region being disposed about the cover inner surface and adjacent the treated cover region. In yet another embodiment, the treated cover region extends inward from the cover outer surface a predetermined depth DCTr and the untreated cover region is disposed between the cover inner surface and the treated cover region a predetermined depth DCUTr, said treated cover region being treated with and/or a comprising a fatty acid and/or fatty acid salt composition wherein the treated cover region comprises a hardness α and the untreated cover region comprises a hardness β that is different than the hardness α.
US08523707B2 Multi-piece solid golf ball
The invention provides a multi-piece solid golf ball having a core, an envelope layer enclosing the core, an intermediate layer enclosing the envelope layer, and a cover which encloses the intermediate layer and has formed on a surface thereof a plurality of dimples. The core is formed primarily of a rubber material and has a diameter of at least 31 mm, the envelope layer and the intermediate layer are each formed primarily of the same or different resin materials, and the cover is formed primarily of polyurethane. The envelope layer, intermediate layer and cover have thicknesses which satisfy the relationship cover thicknesscover surface hardness. The golf ball has an excellent flight performance and controllability that are acceptable to professionals and other skilled golfers, while also having an excellent durability to cracking on repeated impact and an excellent scuff resistance.
US08523701B2 Interchangeable shaft system
A golf club incorporating an interchangeable shaft system includes a shaft, a shaft sleeve, a club head. The shaft sleeve is coupled to an end of the shaft and is received in a hosel included in the club head. The shaft sleeve is removably coupled to the club head. Hosel and shaft sleeve alignment features provide discrete orientations between the shaft and club head.
US08523696B2 Golf swing analysis method using attachable acceleration sensors
A swing analysis method of the present invention includes steps of: preparing a radio type acceleration measuring device 4 capable of measuring respective accelerations in three axis directions; mounting the acceleration measuring device 4 to a golf player's body t1; receiving measured data from the acceleration measuring device 4 during a swing through radio communication; and analyzing a golf swing based on the acceleration data. Preferably, the acceleration measuring device is attached to each of two or more portions of the tester t1. Preferably, an attached position of the acceleration measuring device is any part selected from the group consisting of a head, a neck, a shoulder, a back, a waist and a wrist. Preferably, a weight of the acceleration measuring device is equal to or more than 10 g.
US08523695B2 Pool cue and method of manufacturing thereof
A pool cue includes a hollow shaft arrangement having a first end and a second end. The shaft arrangement is formed with a bore extending throughout an entire length of the shaft arrangement between the first and second ends. A carrier for mounting the shaft arrangement thereon includes a central section disposed to be received in the bore. The central section has a first end disposed to be engaged against a first end of the shaft arrangement, and a second end provided with a threaded area disposed to extend beyond the second end of the shaft arrangement. The threaded area is connected to other pool cue structure, such as a joint collar or a shaft section, or both, disposed at the second end of the shaft arrangement.
US08523693B2 Measure your shot
MEASURE YOUR SHOT (M.Y.S.) is a methodology and technology of two billiard balls, each ball including nine (9) one quarter inch (¼″) lines scribed 360 degrees, the lines are scaled to diamonds on rails of a billiard table. With the aid of the diamonds and lines it becomes simple for a user and spectators to recognize the type of shot. The training balls provide a tool for improving a user's shot.
US08523692B2 Flame barrier, apparatus and method for entertaining guests
An apparatus for entertaining multiple guests includes a device that selectively generates a flame and a barrier interposed between each guest and the flame. The barrier is configured to remain transparent throughout multiple repetitions of use of the device for generating a flame. A method of entertaining guests is also presented.
US08523689B2 Axially adjustable driveshaft assembly
An axially adjustable driveshaft assembly in a drive train system is described. Two hollow driveshaft sections, where one has a valve through an aperture in it and each has an end fitting, engage each other to form an axially adjustable driveshaft assembly that has a sealed internal chamber within. When a pressurized air or vacuum source is connected to the valve, air fills the chamber or air is removed from the chamber, which correspondingly increases or decreases a drive train system length. This results in facilitating the installation of the driveshaft assembly between a transmission and an axle assembly in a drive train system.
US08523688B2 Hanger bearing coupling
A hanger bearing coupling includes a bearing for supporting a shaft, the bearing including an inner race mounted onto the shaft, the bearing mounted between at least two hub assemblies mounted one on either side of the bearing on the shaft; and a hanger including an opening for receiving the bearing there through for operably connecting the bearing to the hanger. Each hub assembly including an inner flex hub mounted to the shaft and an outer flex hub resiliently mounted to the inner flex hub wherein the outer flex hubs are adapted to connect to tubular shafts which may be longitudinally misaligned.
US08523685B2 Torque fluctuation absorber
A torque fluctuation absorber includes a first rotary member formed into an annular shape and including a first protruding portion formed at an inner circumferential surface, a second rotary member connected to the first rotary member, a third rotary member including a second protruding portion formed at an outer circumferential surface, a damper portion absorbing torque fluctuations caused by torsion generated between the second rotary member and the third rotary member, and an elastic member arranged between the first protruding portion and the second protruding portion and absorbing a shock generated when the first protruding portion directly makes contact with the second protruding portion when the damper portion absorbs the torque fluctuations caused by the torsion generated between the second rotary member and the third rotary member.
US08523683B2 Storage medium storing game program, game apparatus and game control method
A video game apparatus includes a CPU, the CPU detects marker coordinates data included in input data transmitted from a controller, and calculates indicated coordinates of the controller. A star object indicated by the controller is set as a target object by a player pressing a B-trigger switch. Then, a player object executes a processing according to the target object. For example, when the player continues to press the B-trigger switch, the player object is moved to approach the target object.
US08523680B2 Service providing method using on-line game, and recording media recording program for implementing the method
An approach is provided for providing a service using an on-line game capable of, maximizing effects of services associated with the on-line game, and recording media recording a program for implementing the service providing method. The service providing method may include, for example, storing, in a rendering region, game object drawing information of a game screen for the on-line game in response to a request for reproducing the game screen; hooking the rendering region to change the game object drawing information so that service object information provided from a game server is included in the game object drawing information; storing the changed game object drawing information in the rendering region; and providing the game screen by rendering the game object drawing information including the service object information stored in the rendering region.
US08523679B2 System and method for streaming a lottery game
A system and method for streaming a lottery game is described. The system includes a lottery ticket, a gaming server, a paytable, a video server, a network access device, an encryption module, and IP address associated with the network access device. The lottery ticket has a first plurality of numbers. The gaming server is configured to generate a second plurality of numbers with a random number generator. The paytable includes an award that is based on a comparison of the first plurality of numbers to the second plurality of numbers. The video server stores a plurality of images associated with the award. The network access device is configured to present the lottery. The encryption module configured to encrypt communications between the gaming server and the network access device. The IP address associated with the network access device enables secure communications with the gaming server.
US08523673B1 Vocally interactive video game mechanism for displaying recorded physical characteristics of a player in a virtual world and in a physical game space via one or more holographic images
The present invention is a vocally interactive video gaming mechanism. A microphone is connected to a video game system for allowing a player in a room to communicate by voice within the game. A video recording device is also provided for scanning and recording the physical characteristics of the player to be projected into the gaming world. A holographic projector projects the recorded physical characteristics of the player into the room in which the player is engaged in the game. Messages can be received from a telephone, a cell phone, a personal digital assistant, or a digital processor. Game progress can be halted in order for the player to answer or respond or to ignore the message. Movements of the player are tracked and converted into movements of the holographic projection of the player in real time. Voice recognition software enables translation of speech from one language into another language.
US08523665B2 Gaming system and method having multi-level mystery triggered progressive awards
A gaming system including a central server linked to a plurality of gaming machines. The gaming system includes at least one and preferably a plurality of progressive awards wherein upon a suitable initiating event, a wager amount or value is randomly generated from at least one predetermined range of wager amounts or values. Upon a suitable triggering event, such as an accumulated wager pool incrementing to the randomly generated wager amount or value, a designated award, such as a progressive award, is provided to a player. In one such embodiment, upon the occurrence of the triggering event, an independent determination occurs regarding which one of the plurality of progressive awards will be provided to a player.
US08523664B2 Machine having a card processing assembly
A machine having a card processing assembly. The machine has a plurality of card holders connectable to the card processing assembly. One card holder is configured to hold data cards associated with one condition. At least one other card holder is configured to hold data cards associated with another condition.
US08523663B2 Transporting and using wagering game data
A wagering game system and its operations are described herein. In embodiments, the operations can include determining a connection of a portable wagering game player drive to a wagering game network. The operations can include determining a player preference regarding a focus of data to store and storing player experience data from the wagering game network according to the player preference. The operations can further include determining a request to disconnect the portable wagering game player drive from the wagering game network, securing the player experience data for transfer beyond the wagering game network; and presenting wagering game content using a computing device outside of the wagering game network using at least some of the player experience data from the portable wagering game player drive.
US08523654B2 Method of gaming, a game controller and a gaming system
A method of gaming comprising: selecting a plurality of symbols for display at a plurality of display positions, the selecting being performed by selecting from a set of symbols including one or more modifiable symbols, each modifiable symbol adapted to receive a modifier; determining whether a corresponding modifier is a available for each selected modifiable symbol; modifying each selected modifiable symbol in respect of which a positive determination is made by adding the modifier to the modifiable symbol; and determining whether to make an award based on the plurality of symbols as modified.
US08523651B2 Apparatus and method for playing a game
A gaming system and method that analyzes and evaluates a player's play input in accordance with a statistically optimal play and generates an acknowledgement where the play input is consistent with an optimum play in response to a particular game condition. The gaming system features at least one display device, at least one player input device, at least one programmable processor coupled to the display device and at least one storage unit coupled to the processor. The storage unit stores a plurality of instructions executable by the programmable processor for performing the method.
US08523650B2 System gaming
A method provides a player tracking system and system gaming apparatus for playing non-base games by funding the credit side of a gaming cycle. The system further includes at least one gaming device having a base game. The player tracking system and system gaming apparatus includes a player tracking user interface. The player tracking user interface provides a player with an opportunity to select and play a non-base game that may be promotional-funded or player-funded.
US08523648B2 Game, such as electronic collectable and card or tradable object game employing customizable features
A game employing user-modifiable game components, such as cards in a collectable card game, employs various features to provide user-modifiability, including sleeves, transparent cards, stickers, and other elements. Electronic versions of the game and various other features are included, including tracking of history associated with such components.
US08523646B2 Program for racing game device, storage medium storing the program, and racing game device
A racing game device comprises means for setting paths in a virtual space in advance as a course for a moving object, means for setting a first path used during normal moving and a second path used only while a special mode is activated, and means for allowing the moving object to move onto the second path (e.g., a ceiling surface part) when the special mode (e.g., a mode allowing the operation of gravity) is activated by an activation instruction from the operating means. Further, the racing game device includes means for setting, while a moving object is moving on the second path, a merging point which merges with the first path when it is judged that a predetermined condition is fulfilled, and means for allowing, when it is judged that the predetermined condition is fulfilled, the moving object moving on the second path to merge at the merging point.
US08523644B2 Operation unit
An operation unit, comprising a wall and an air flow unit, said air flow unit being provided with means for filtering said air, said wall being provided with at least one opening and a cover, covering at least part of said opening, said air flow unit comprising at least one air outlet opening for directing air from said air flow unit over said cover, air inlet means preferably being provided for retracting air to said air flow unit.
US08523641B2 System, method and apparatus for automatically filling a coin cassette
An automated coin tray refilling system includes a plurality of coin reservoirs and a plurality of coin dispensers for regulating the dispensing of coins from an associated one of the plurality of coin reservoirs. A collector point distribution member is adapted to receive coins from each of the plurality of coin dispensers at one portion thereof and to output the coins at another portion thereof. An interface module having an input end is disposed substantially adjacent the collector point distribution member output and includes an output end for dispensing coins. A coin interface tray is adapted to receive at least one coin tray and at least one processor is provided. The interface module and/or coin interface tray includes a drive system configured to move interface module and/or coin interface tray relative to one another.
US08523637B2 Angle grinder dust shroud with slideable access hatch
A dust shroud for an angle grinder includes an access hatch which slides along the shroud body to selectively expose an edge of a grinding disc to allow grinding into a corner. The hatch remains attached to the shroud body in both the open and closed position, making the hatch easier to use and less likely to become lost, resulting in increased worker compliance in properly using the hatch.
US08523636B2 Working object grinding method
A working object grinding method capable of grinding a working object reliably is provided. A working object 1 is irradiated with a laser beam while locating a converging point therewithin, so as to form a reformed region 7 in the working object 1 along a reformed-region forming line set at a predetermined distance inside from an outer edge of the working object 1 along the outer edge, and a rear face 21 of the working object 1 is ground. As a result, the reformed region 7 or fissures C1 extending therefrom can inhibit fissures generated in an outer edge portion 25 upon grinding the working object 1 from advancing to the inside, whereby the working object 1 can be prevented from fracturing.
US08523634B2 Method for the grinding of a profile of a workpiece
The invention relates to a method for the grinding of a profile (1) of a workpiece (2) with a gear or profile grinding machine (3), wherein the profile (1) which has to be ground is successively at first ground during a roughing operation with a roughing grinding tool (4) and is afterwards ground during a finishing operation with a finishing grinding tool (5), wherein a stock of the profile (1) which has to be removed is ground by the roughing and the finishing operation, wherein the roughing grinding tool (4) and the finishing grinding tool (5) are arranged coaxially on a common tool spindle (6) or on two separate tool spindles and wherein a translational movement is created between the grinding tools (4, 5) and the workpiece (2) in a direction of a first axis (x) for carrying out a grinding stroke. To improve the cost effectiveness and the quality of the grinding process the invention is characterized in that the at least one tool spindle (6) or the workpiece (2) is swiveled around an axis (A) of rotation which is directed in the direction of the first axis (x) by a predetermined angle (α) during the execution of the roughing operation or the finishing operation from a basic position (I) into a swivel position (II) in such a way that the grinding tool (5) which is not in operation can be passed over the profile (1) to be machined without collision.
US08523633B2 Method for producing a spectacle lens
A method for producing a semi-finished product for a plus or minus power lens having a toroidal or atoroidal back that is configured as a prescription surface. According to the method, a blank having a diameter DR and a front having a radius of curvature rV is fixed on its front for the purpose of machining the back and is subjected to cutting, the prescription surface being produced only across a part of the diameter D. Deviating from the curvature of the prescription surface a dimension is left, thereby producing an additional surface, either in the areas of the back in which the generation of the base radius rB would result in the thickness hB of the edge being smaller than the minimum dimension hmin, so that the thickness of the semi-finished product is not smaller than the minimum dimension hmin at any point, and the maximum thickness hB of the edge being five times as large as the thinnest point S of the semi-finished product, or in the areas of the back where the generation of the cylinder radius rZ would result in the edge being thicker than a thickness hB of the edge of the semi-finished product in a plane EB of the base radius rB, the thickness is reduced so that the thickness of the semi-finished product so produced does not exceed the maximum dimension hB at any point.
US08523631B2 Athletic bra
A bra to be worn during vigorous physical activity includes a stretch front panel and a stretch back panel. The back panel forms a back portion of a left and right shoulder strap. Non-stretch fabric connects the front panel and the back panel and forms the front portion of the left and right shoulder straps. The bra also includes a rib band configured to encircle a wearer's torso.
US08523630B2 Device and method for immobilizing patients for breast radiation therapy
According to the improved systems and methods described herein, a patient may be immobilized so that one or both breasts are returned to a known position. Additionally, the improved systems and methods reduce respiratory movement of the breasts. Thus, the immobilization devices and techniques described herein provide accurate and reproducible breast positioning while simultaneously reducing respiratory motion.
US08523628B2 Noise producing toy structure
A noise producing toy structure includes a toy having an outer wall and a crown raised from the outer wall, the outer wall defining an inner space and the crown defining a chamber; an opening for passing ambient fluid into the chamber; and a noise producing element placing the inner space in fluid communication with chamber. The crown hinders access to the noise producing element to resist unintended removal of the noise producing element. A noise producing toy structure includes a toy having an outer wall, a noise producing element disposed in the outer wall for placing the inner space in fluid communication with an environment; and a wall upright from the outer wall at a position proximal to the noise producing element. The wall has a free end to space a user from the noise producing element to hinder access to the noise producing element.
US08523625B2 Method of manufacturing spark plug
A method of manufacturing a spark plug wherein a tip having a burr-free surface is more reliably welded to a ground electrode, to thereby realize an excellent joint strength. The spark plug includes a center electrode, a ground electrode, and a ground-electrode-side tip joined to the ground electrode through its joining surface. The method of manufacturing includes a tip forming step and a tip joining step of resistance-welding the ground-electrode-side tip to the ground electrode. A wire rod having a reference surface is formed, and the wire rod is cut by moving a cutting blade from one edge of the reference surface with respect to the width direction thereof toward the other edge of the reference surface with respect to the width direction, thereby obtaining the ground-electrode-side tip. At least a portion of the reference surface is joined to the ground electrode, whereby that portion becomes the joining surface.
US08523623B2 Collapsible flotation device
A device comprises a spring and a sleeve. The spring is configured to form a closed loop. The spring is moveable between a coiled configuration when the spring is collapsed and an uncoiled configuration when the spring is expanded. The spring defines a circumference while in the uncoiled configuration. The spring is disposed within the sleeve.
US08523621B2 Cover for inflatable tube
The cover for inflatable tube includes a hollow, toroidal member made from a durable, puncture-resistant, abrasion-resistant fabric, the toroidal member being adapted for covering an inflatable float tube. The cover may also include a plurality of spaced, elongate, flexible eyelets are formed about a periphery of the cover portion on the outer surface and are arranged to extend radially about the periphery of the cover. The cover may further include a flat bottom member the extends across the annular opening defined by the toroidal member, providing a flat surface so that the tube may be used for sledding on snow-covered surfaces, or to prevent swimmers from extending their torsos through the tube, thereby permitting the swimmers to sit on the bottom sheet instead of dangling their feet below the tube, presenting the risk that the swimmer's foot may be entrapped by underwater obstructions in a river or other shallow water.
US08523613B2 Electrical connector for broadside coupled or edge coupled mating with mating connector
An electrical connector (100) includes a housing (1) and a number of contacts (2) mounted on the housing. The housing includes a mounting portion (11), and a receiving room (10) on one side of the mounting portion. Each of the contacts (2) includes a body portion (21) mounted on the mounting portion, and a mating portion (22) extending form the body portion and projecting into the receiving room. The mounting portion includes a number of mounting slot (14) each including a first slot (15) and a second slot (16) crossed with the first slot. The contacts are selectively mounted on either the first slots or the second slots.
US08523611B2 Electrical connector having contact modules with differential pairs on both sides of a printed circuit board
An electrical connector comprises a printed circuit board (12) having a rear edge connected to the cable (10) and a front edge opposite to the rear edge, a number of upper contact modules (21) stacked along the front edge on a top side (122) of the printed circuit board (12), and a number of lower contact modules (22) stacked along the front edge on a bottom side 124 of the printed circuit board (12). Each of the contact modules (21, 22) has a conductor pairs (14) for transferring signal differential pairs lined along a column direction perpendicular to the printed circuit board (12) and an insulator (152, 156) encapsulating a portion of each conductor (14) of the conductor pairs.
US08523607B2 Cable with connector and manufacturing method thereof
[Problem] To provide a cable with a connector which can enhance simply and readily accuracy of the relative positions among plural connector units and does not cause connection failure, and a manufacturing method of the same.[Solving Means] In a cable with a connector, a hybrid connector 1 holding a plurality of connector units 2 to 4 in a common connector housing 5 is connected to at least one end of a hybrid cable 9. The connector housing 5 has a recess groove 18 for accommodating and holding therein a flange portion 15a to 17a of the connector unit 2 to 4. The recess groove has a clearance which enables positional adjustment of the connector unit in a direction orthogonal to an axial direction of connection of the connector unit. A thermosetting adhesive 19 is applied to the clearance, whereby the plurality of connector units are bonded and fixed to the connector housing with the predetermined relative positions and intervals.
US08523604B2 Terminal block and terminal block manufacturing method
A terminal block has conductors extending from devices placed one over another placed on nuts (10) and fastened by a bolt. A heat sink (40) is arranged below the nuts and an insulating plate (20) is sandwiched in close contact with the nuts (10) and the heat sink (40). A molded resin part (60) covers these three members (10, 20 and 40). The insulating plate (20) includes nut accommodating portions (21) capable of accommodating the nuts (10) and bolt escaping recesses (26) projecting downward from a bottom plate (22) of the insulating plate (20). The heat sink (40) includes accommodation recesses (43) into which the bolt escaping recesses (26) fit. The molded resin part (60) is molded with the nuts (10) accommodated in the nut accommodating portions (21) and the accommodation recesses (43) and the bolt escaping recesses (26) fit to each other.
US08523603B2 Connector assembly
A connector assembly includes a first connector and a second connector. The second connector is engageable with the first connector along a downward direction in a state where the first connector is below the second connector. The second connector includes a second contact, a second holding member and an operating portion. The operating portion is held by the second holding member so that a positional relation therebetween is kept when a force is applied to the operating portion along an upward direction and when a force is applied to the operating portion along a first horizontal direction perpendicular to the upward direction or a second horizontal direction opposite to the first horizontal direction. The second connector is removable from the first connector when a force is applied to the operating portion either along the upward direction or along the first or second horizontal direction.
US08523601B2 Line receptacle device with strain relief
A line receptacle device comprising a first housing part, a second housing part, an entry channel for a line and a strain relief device that is configured to move from a first position into a second position, and if configured such that, in the first position the line can be introduced through the entry channel and in the second position the line can be clamped into the entry channel, in which case the strain relief device also has a locking device which, on transition from the first position into the second position, interacts with a retaining device disposed in the first housing part and the second housing part such that the housing parts are locked together.
US08523598B2 Electrical connector assembly with a latch easy to be operated
An electrical connector assembly (100), comprising: an insulative housing (1) having at least one receiving space formed therein; a latch (3) formed on a top surface of the insulative housing, the latch defining a front end connected to the top surface and a rear end cantilevered from the front end; and two PCB modules (2) received into each receiving space (11), one of the two PCB modules defining a holding portion (231) holding the rear end of the latch.
US08523597B2 Releasably engaging high definition multimedia interface plug
A high definition multimedia interface connector comprising a connector body having an extension configured to be inserted into a high definition multimedia interface receptacle, and at least one projection on an outer surface of the extension to facilitate releasable engagement of the plug with a standard high definition multimedia receptacle. A corresponding method of releasably securing a high definition multimedia interface plug to a standard high definition multimedia interface receptacle is also provided.
US08523593B2 Standard receptacle connector with plug detecting functions and sink-type receptacle connector with plug detecting functions
A standard receptacle connector has an insulating housing, multiple first terminals, multiple second terminals, a plug detecting terminal and a shell. The first and second terminals and the plug detecting terminal are mounted on the insulating housing. The shell covers the insulating housing and all of the terminals. The plug detecting terminal is capable of being connected to a controlling circuit incorporated in a PCB on which the standard receptacle connector is mounted and selectively activates the controlling circuit to provide power to an external plug connector that is inserted in and connected to the standard receptacle connector.
US08523586B2 Terminating and connecting device
A terminating and connecting device with a housing having a lower and upper housing parts, at least one contact spring for electrically contacting at least one terminal lead, at least one terminal element for connecting at least one cable, and at least one metal part for connecting the contact spring to a cable connected by the terminal element. The housing upper part has at least one actuating element and a contact spring. The contact spring has two contact legs connected by a back, and the lower housing part has a top spring has two spring legs and a back which connects the spring legs. When the housing upper part is pressed onto the housing lower part, the actuating element presses on the back of the top spring so that the top spring moves into a position such that the terminal lead is clamped between the contact legs.
US08523584B2 Web membrane connector seal
A connector includes a connector body having cavities with through-holes disposed therein. Sealing membranes are received in the cavities and serve to protect the connector from the environment. Wire conductors may pierce the sealing membranes, and may be received by the through-holes of the cavities in the connector. In cavities in which wire conductors have been received, each sealing membrane forms a seal around a corresponding wire conductor. The connector body is formed from a first material, and the sealing membranes are formed from a second material, different from the first material.
US08523582B2 Locate wire connector and locate wire grounding method
A locate wire connector provides a grounding wire connection for the locate wire of a fiber optic cable. The locate wire is partially separated from the fiber optic cable. A conductive stripper in the connector establishes electrical communication with the locate wire conductor upon placing the locate wire and fiber optic cable in the connector and closing same. A stud extending from the cover of the connector provides a terminal for connecting a ground wire. The connector may also contain a gel to ensure a waterproof grounding connection.
US08523577B1 Electrical connector
An electrical connector includes an insulating housing having a base body of which a front surface is inclined to act as a mating face. The mating face is concaved rearward to define a plurality of terminal grooves penetrating through the base body and a plurality of receiving grooves of substantial U-shape each surrounding one of the terminal grooves. Wherein there are some terminal grooves without being surrounded by any receiving grooves and each of them is located between every two adjacent receiving grooves. A plurality of terminals is inserted forward in the terminal grooves of the insulating housing respectively. Each terminal has a contact end exposed outside through a front end of the corresponding terminal groove. A plurality of magnet units each is of substantial U-shape and is assembled in the receiving groove of the insulating housing.
US08523574B1 Microprocessor based vocabulary game
An educational word game for play on a cell phone or hand held device that utilizes the linguistic concept of onsets and rimes in order to teach and develop skills in pairing and forming appropriate sets of said onset and rimes in order to form full words.
US08523573B1 “2 × 3” math learning game
A mathematical education game including a first series of cards to be dealt to a plurality of players containing the result of a mathematical operation, and another series of cards each containing a mathematical operation corresponding to a least one of the results on the first series of cards, whereby one of said series of cards is designated as the set of “answer” cards and a plurality of said answer cards are distributed to the players while the other is designated as the set of “question” cards to be asked serially by a judge, whereupon in each round the players having a correct answer to the displayed question may transfer their matching card to the judge, with the winner being the first player to turn in all of his or her cards to the judge, and whereupon during successive games the sets of question and answer cards are reversed.