Document Document Title
US08507878B1 Scintillation materials with reduced afterglow and method of preparation
Scintillation materials of this invention have an alkali halide host material, a (first) scintillation dopant of various types, and a variety of second dopants (co-dopants). In another embodiment, the scintillation materials of this invention have an alkali halide host material, a (first) scintillation dopant of various types, a variety of second dopants (co-dopants), and a variety of third dopants (co-dopants). Co-dopants of this invention are capable of providing a second auxiliary luminescent cation dopant, capable of introducing an anion size and electronegativity mismatch, capable of introducing a mismatch of anion charge, or introducing a mismatch of cation charge in the host material.
US08507876B2 Device for holding electron microscope grids and other materials
A device for holding a specimen holder, the device including a body with a slot formed therein. The slot includes an interior for receiving the specimen holder which may be a flat disk with edges and a pair of opposing sides. The disk may be made of a resilient deformable material. The slot may be sized to receive the specimen holder through an open top end and may taper from top bottom, such that the bottom end of the slot is smaller than the specimen holder. The slot further configured to contact the specimen holder along edges of the specimen holder and to allow some sideways deformation of the specimen holder without either side of the specimen holder distant from the edges coming into contact with the interior of the slot.
US08507872B2 Neutron detection
A neutron detector includes a microchannel plate having a structure that defines a plurality of microchannels, and layers of materials disposed on walls of the microchannels. The layers include a layer of neutron sensitive material, a layer of semiconducting material, and a layer of electron emissive material. For example, the layer of neutron sensitive material can include boron-10, lithium-6, or gadolinium.
US08507871B2 Radiation detection element and radiographic imaging apparatus
The present invention provides a radiation detecting element and a radiographic imaging device that may reliably detect irradiation of radiation even when a region where radiation is irradiated is set narrowly. Namely, the present invention provides a radiation detection element and a radiographic imaging apparatus, in which radiographic imaging pixels and radiation detection pixels are provided at intersecting portions of scan lines and signal lines.
US08507870B2 Solid-state imaging apparatus and imaging system
An imaging apparatus has an imaging area formed by arranging a plurality of imaging blocks each including a pixel array, a plurality of vertical signal lines, a horizontal output line commonly provided for the plurality of vertical signal lines to read out signals read out to the plurality of vertical signal lines, a first scanning circuit, and a second scanning circuit, wherein signals of the pixels of a selected row in the pixel array are read out to the plurality of vertical signal lines in accordance with a driving pulse from the first scanning circuit, the signals read out to the plurality of vertical signal lines are sequentially read out to the horizontal output line in accordance with a driving pulse from the second scanning circuit, and a length in a row direction of the pixel array is smaller than a length in a column direction of the pixel array.
US08507868B2 Systems and methods for determining fluid mobility in rock samples
Systems and methods for determining fluid mobility in rock samples using time-lapse position emission particle tracking (PEPT). The systems and methods use PEPT to determine permeability in rock samples, such as shale, that have a permeability of less than one micro-darcy by recording gamma-ray emissions from a tag using a positron emission tomography camera as the tag traverses with a fluid through the pores in the rock sample.
US08507863B2 Reflective proximity sensor with improved smudge resistance and reduced crosstalk
An electronic device includes a protective layer above a proximity sensor having a radiation emitter and a radiation detector. A groove, which may be wedge shaped, is formed in the bottom surface of the protective layer. A radiation barrier, which may be reflective or absorptive material, is placed in the groove in the bottom surface of the protective layer. A light blocking coating may be applied to the bottom surface and the groove of the protective layer to prevent the passage of visible radiation and permit the passage of infrared radiation. A radiation shield may be positioned between the emitter and the detector directly below the radiation barrier. Alignment features may be formed on the mating surfaces of the radiation barrier and radiation shield to align the protective layer with respect to the radiation shield and proximity sensor.
US08507860B2 Terahertz resonator
A tunable terahertz resonator includes a semiconductor substrate and a metal layer contacting a surface of the semiconductor substrate. A depletion layer is formed in the semiconductor substrate near an interface between the metal layer and the semiconductor substrate. A chiral nanostructure is coupled to the substrate or the metal layer, the chiral nanostructure including a conducting or semiconducting material and having an inductance. A bias circuit applies a bias voltage across the metal layer and the semiconductor substrate to control a capacitance of a tunable capacitor that includes the depletion layer. The chiral nanostructure and the tunable capacitor form a tunable resonant circuit. The tunable terahertz resonator can be used in a terahertz radiation emitter or receiver.
US08507858B2 Pattern measurement apparatus and pattern measurement method
Referring to design data for a sample, a measurement region is defined at a portion in the design data which has no step in an edge of a pattern. In addition, an edge as a characteristic portion is detected from the design data, and an edge as a characteristic portion corresponding to the characteristic portion of the design data is detected from a secondary electron image. Then, the measurement region is positioned and located in a secondary electron image based on a positional relationship between the edge of the design data and the edge of the secondary electron image. A width of the pattern is measured on the basis of a distance between the two edges included in the measurement region thus located.
US08507854B2 Particle beam microscopy system and method for operating the same
A particle beam system 1 for cleaning itself comprises an irradiation system to direct electromagnetic radiation onto the surfaces to be cleaned and a supply system 61 to supply a precursor gas to the interior of the vacuum chamber 11 of the particle beam system 1. The precursor gas is activated in a vicinity of the surfaces to be cleaned and is converted into a reaction gas which reacts with the contaminants present on the irradiated surfaces such that said contaminants may be pumped out then.
US08507849B2 Mass spectrometer
A mass spectrometer is disclosed comprising a MALDI ion source coupled to an orthogonal acceleration Time of Flight mass analyzer. The mass spectrometer is operated at a first instrument setting wherein specific parent ions are selected by a mass filter and are accelerated to a first axial energy. The fragment ions are then orthogonally accelerated after a first delay time and first mass spectral data is obtained. The mass spectrometer is then operated at a second instrument setting wherein the axial energy of the parent ions is increased and the resulting fragment ions are orthogonally accelerated after a reduced delay time. Second mass spectral data is then obtained. The first and second mass spectral data are then combined to provided a final composite mass spectrum.
US08507843B2 Method and system for spectral calibration of a remote sensing sensor and a synthetic target having a tunable spectral composition
A method and a system for spectral calibration of a remote sensing sensor and a synthetic target having a tunable spectral composition are described. The system or synthetic target includes a plurality of reflective mirrors arranged to reflect radiation from a source of radiation onto a remotely located radiation sensor. A first mirror in the plurality of mirrors is configured to reflect a first portion of the radiation in a first wavelength toward the remotely located radiation sensor. A second mirror in the plurality of mirrors is configured to reflect a second portion of the radiation in a second wavelength different from the first wavelength toward the remotely located radiation sensor. The first portion of the radiation and the second portion of the radiation can be selected to calibrate the remotely located radiation sensor so as to provide a quantitative spectral relationship between the radiation detected at the remotely located sensor and the radiation reflected by the plurality of mirrors.
US08507841B2 Optical element and method for producing the same
An optical element having an anti-reflection function includes a base having a first main surface and a second main surface; a plurality of structures composed of projections or recesses and arranged on the first main surface at a fine pitch equal to or less than the wavelength of visible light for which the amount of reflection is to be reduced; and a light-absorbing layer that absorbs the light and that is disposed on the second main surface, wherein the structures are arranged so as to form a plurality of rows of tracks on the first main surface and form a hexagonal lattice pattern, a quasi-hexagonal lattice pattern, a tetragonal lattice pattern, or a quasi-tetragonal lattice pattern, and the structures each have an elliptical cone shape or a truncated elliptical cone shape, the major axis direction of which is a direction in which the tracks extend.
US08507837B2 Techniques for monitoring solar array performance and applications thereof
An automated method to monitor performance of a terrestrial solar cell array tracking the sun. The solar cell system includes drive means that adjust a position of the array along different respective axes with respect to the sun using the drive means. The techniques include predicting the position of the sun during a time period, and sampling an output parameter of the array indicative of performance. The sampled data may be used to identify a fault in the solar cell array, for example a misalignment or a failure of one or more solar cells, in which case a notification of that fault may be generated for the operator or a control signal may be output for correcting the fault. Alternatively, an output signal may be sent to an external system associated with the solar cell system. Various alignment testing routines for checking the solar tracking are described. These routines may involve moving a solar cell array to a reference position at the start of, or during, an alignment routine in order to improve accuracy of position measurement during the routine.
US08507836B1 Software defined lensing
The invention relates to imaging devices and methods, pertinent to electromagnetic energy in visual and other spectra, to capture and reproduce substantially all image information in a relevant spectrum through all-electronic sensors and electronic computation means.
US08507831B2 Heater for an automotive vehicle and method of forming same
There is disclosed a heater for an automotive vehicle or other article of manufacture. The heater typically includes a first conductive medium and a second conductive medium disposed upon a carrier. In a preferred embodiment, the first conductive medium includes a first section and a second section that are electrically connected by a second conductive medium. The second conductive medium preferably exhibits a positive thermal coefficient.
US08507829B2 Method for producing coarse surface structures
A method for producing rough surface structures comprising the following step: running a laser beam along filling lines (1) over an area to be processed, wherein the filling line (1) is broken down into particular laser dots (2) with a distance a, and wherein the laser dots (2) are moved in a X direction and in a Y direction in a plane with a random factor b relative to the filling line (1) so that they form a cloud of dots.
US08507822B2 Contact member including purposely introduced undulations and vacuum interrupter including the same
A contact is for a vacuum interrupter. The contact includes a contact member having a generally planar mating surface with a planar contact plane and a plurality of purposely introduced undulations therein. The undulations are structured to contact a plurality of purposely introduced undulations of another contact member. The undulations are in a dimension perpendicular to the planar contact plane. The planar contact plane has a diameter. The undulations have a depth substantially smaller than the diameter of the planar contact plane.
US08507820B2 Sealed dome switch for mobile electronic device
A mobile electronic device has a dome switch assembly secured to the housing of the device, over a recess formed in the housing of device. The dome switch assembly has a substrate with a vent hole communicating between the recess of the housing and the space comprised between the substrate and a dome actuation portion of the dome switch assembly. Upon actuation of the dome switch assembly, air present between the dome actuation portion and the substrate flows into the recess of the housing.
US08507813B2 Integrating impact switch
An integrating impact switch that can discriminate between accelerations due to different stimuli is provided. Embodiments of the present invention actuate only in response to an acceleration whose magnitude is equal to or greater than an acceleration threshold for a predetermined continuous period of time. Embodiments of the present invention comprise an impact switch having a throw that is operatively coupled with a viscous damper that dampens motion of the throw. As a result, a stimulus that imparts an acceleration that meets or exceeds an acceleration threshold for a time period less than a predetermined time-period threshold does not actuate the switch. A stimulus that imparts an acceleration whose magnitude is equal to or greater than the acceleration threshold for a time period equal to the time-period threshold, however, does actuate the switch.
US08507812B2 Switch assembly and earphone set with the same
A switch assembly and an earphone set having the same. The switch assembly includes a first plate in which a board is mounted, a second plate installed opposite the first plate, a connection member provided between the first and second plates so as to resiliently connect the first and second plates, a plurality of first contacts provided on a rear face thereof in order to selectively connect a circuit of the board, and a plurality of second contacts provided on a front face thereof in correspondence to the first contacts.
US08507810B2 Dynamic scale utilizing shear measurements to determine a weight of bulk material
The invention relates to a dynamic scale for bulk material, having two swivel arms (2) and two load-lifting arms (8) mounted to the free end of said swivel arms, with one hole (7) being located in each of the swivel arms (2) and positioned transversely to the extension of the swivel arm and also transversely to the neutral fiber brought about by the flexural load. A pipe (9) is fitted into the hole (7) and is welded thereto. The pipe (9) comprises two sensors (14, 15) transversely to the longitudinal axis thereof, said sensors being located at an angle of substantially 90° to each other and each being disposed at an angle of ±45° to the direction of the shear stress component τxy. Under the influence of the shear stress, the cross section of the tube (9) is deformed into an ellipse that is inclined at about 45°, the shorter and longer axis (11, 13) thereof being measured using the sensors (14, 15). Said sensors (14, 15) each comprise two force inlets (16, 17), which are inserted with pretension in suitable recesses in the tube (9).
US08507807B2 Wiring board
A wiring board includes at least one signal layer, at least one ground layer, at least one power plane, at least one power supply via that electrically conducts wiring over one substrate surface where a semiconductor device chip is mounted, wiring over another substrate surface, and the power plane, and signal wiring for performing signal transmission between a plurality of semiconductor device chips. The power plane is placed to the one substrate surface side than the signal wiring. The power supply via is composed of a large diameter aperture and a small diameter aperture. The large diameter aperture has a relatively large diameter and is formed from the one substrate surface to the power plane, and the small diameter aperture has a relatively small diameter and is formed from the power plane to the other substrate surface.
US08507806B2 Heat resistant substrate incorporated circuit wiring board
A circuit wiring board including a wiring substrate, and a heat resistant substrate accommodated in the wiring substrate and including a core substrate and a through hole conductor formed in the core substrate, the core substrate having a first surface and a second surface on an opposite side of the first surface, the through hole conductor providing electrical connection through the core substrate between the first surface and the second surface of the core substrate.
US08507805B2 Wiring board for semiconductor devices, semiconductor device, electronic device, and motherboard
In a wiring board according to the present invention, a substrate, a solder resist provided on the substrate, a land, a wiring line, and a connection portion connecting the wiring line and the land, the connection portion is provided with a recess as a non-flat portion, and is formed to comprise a width greater than a width of the wiring line and smaller than a width (diameter) of the land, the width of the connection portion being gradually increased from the wiring line toward the land.
US08507803B2 Structure of connecting printed wiring boards, method of connecting printed wiring boards, and adhesive having anisotropic conductivity
The invention offers a board-connecting structure that can provide electrodes with a fine pitch and that can combine the insulating property and the connection reliability. The structure of connecting printed wiring boards 10 and 20 electrically connects a plurality of first electrodes 12 and 13 provided to be adjacent to each other on a first board 11 with a plurality of second electrodes 22 and 23 provided to be adjacent to each other on a second board 21 through an adhesive 30 that contains conductive particles 31 and that has anisotropic conductivity. By heating and pressing the adhesive placed between the mutually facing first electrode 12 and second electrode 22 and between the mutually facing first electrode 13 and second electrode 23, an adhesive layer 30a is formed between the first board 11 and the second board 21 and in the adhesive layer 30a, a cavity portion 33 is formed between the first electrodes 12 and 13 and between the second electrodes 22 and 23.
US08507802B1 Ultra-low current printed circuit board
Provided is printed circuit board for minimizing dielectric losses experienced by a low-current portion of an electric circuit. The printed circuit board includes a first substrate supporting an electrically-conductive material patterned to form a conductive pathway between electric circuit components, and a surface-mount guard pad provided on a substantially-planar exposed surface of the first substrate and covering at least an area of the exposed surface including a footprint of the low-current portion on the first substrate. A second substrate is also provided with one or more electrically conductive pads that are surface mounted to the guard pad to couple the second substrate to the guard pad. The second substrate also supports a signal trace included in the low-current region for conducting a low-current signal.
US08507798B2 Sealing grommet
A sealing grommet, particularly for data centers and the like, formed of one or a pair of U-shaped frame sections, each co-molded with a thermoplastic elastomeric seal of corrugated wave form, with corrugated edges of the seals exposed at the open sides of the U-shaped frames. A pair of such grommet sections joined together, with the corrugated edges arranged to be in contact and in phase, provides a uniquely efficient seal to hold back air under pressure while allowing various pass-through elements, such as cables, hoses, etc., to be extended through the grommet and while enabling the pass-through elements to be easily added, removed, or rearranged as may be necessary to accommodate the dynamic changes experienced in the operation of a data center.
US08507790B2 Solar element with increased efficiency and method for increasing efficiency
A solar element with increased efficiency and also a method for increasing the efficiency of a solar cell are provided. The solar cell comprises a luminescent element, an upconverter, and also at least one selectively reflecting structure.
US08507789B2 Solar cell and method of manufacturing the same
A solar cell and a method of manufacturing the same are disclosed. The solar cell includes a substrate of a first conductive type having at least one via hole; an emitter layer only on at least a portion of the via hole and at least one selected from a group consisting of an incident surface and side surfaces of the substrate, the emitter layer having a second conductive type opposite the first conductive type; at least one first electrode on the incident surface, the first electrode being electrically connected to the emitter layer; a second electrode connected to an opposite surface to the incident surface; and at least one first electrode current collector on the opposite surface, the at least one first electrode current collector being insulated from the second electrode and being electrically connected to the at least one first electrode through the via hole.
US08507785B2 Photo induced enhanced field electron emission collector
An electromagnetic energy collector and sensor use enhanced fields to emit electrons for energy collection. The collector and sensor collect energy from visible light, infrared radiation and ultraviolet electromagnetic radiation. The collector and sensor include a waveguide with a geometry selected to enhance the electric field along a conductor to create a high, localized electric field, which causes electron emission across a gap to a return plane.
US08507784B2 Photovoltaic shingles for roofing and method for connecting the shingles
A shingle including a flexible sheet; a photovoltaic panel attached to the flexible sheet; an electrical conductive path extending from a first side of the shingle to an opposite side of the shingle; a connector on one end of the electrical conductive path, and a mating connector on an opposite end of the electrical conductive path.
US08507782B2 Electronic percussion instrument
An electronic percussion instrument generates, in accordance with a trigger signal output from a pad source, a musical performance tone of a tone color assigned to the pad source. The electronic percussion instrument includes a program memory for storing a control program and a CPU for controlling operation of the electronic percussion instrument in accordance with the control program stored in the program memory. A storage device is also provided for storing a plurality of trigger data sets each of which includes at least one sensitivity setting parameter for setting sensitivity to the trigger signal, and a plurality of drum kits each of which includes pad setting data for setting the tone color assigned to the at least one pad source and link data for designating one of the plurality of trigger data sets. A setting operation input unit is provided for selecting a drum kit from among the plurality of drum kits. The CPU is coupled to the storage device and the setting operation input unit and operative under the control program for setting the sensitivity to the trigger signal on the basis of the at least one sensitivity setting parameter included in the trigger data set designated by the link data included in the drum kit selected by the setting operation input unit.
US08507777B2 Guzmania hybrid named ‘TROPIX’
A new and distinct Guzmania hybrid named ‘TROPIX’ characterized by solid growth habit; funnel-form rosette plant, measuring about 35 cm to 50 cm in height (above the pot when flowering); numerous, green color foliage (measuring about 25-45 cm length and about 3-4.5 cm in width) Superior floral bract production; bracts are red in color (closest to RHS 45A); head inflorescence, measuring about 8 cm in height when flowering commences to about 15 cm in height at maturity, and about 12 cm in diameter; and long-lasting habit.
US08507775B2 Plants and seeds of common wheat cultivar SJ909-369
A wheat cultivar, designated SJ909-369, is disclosed. The invention relates to the seeds, plants, and hybrids of wheat cultivar SJ909-369, and to methods for producing a wheat plant produced by crossing plants from wheat cultivar SJ909-369 with themselves or with plants from another wheat variety. The invention also relates to methods for producing a wheat plant containing in its genetic material one or more transgenes and to the transgenic wheat plants and plant parts produced by those methods. The invention also relates to wheat varieties or breeding varieties and plant parts derived from wheat cultivar SJ909-369, to methods for producing other wheat varieties, lines or plant parts derived from wheat cultivar SJ909-369, and to the wheat plants, varieties, and their parts derived from the use of those methods. The invention further relates to hybrid wheat seeds and plants produced by crossing wheat cultivar SJ909-369 with another wheat cultivar.
US08507771B2 Plants and seeds of hybrid corn variety CH864601
According to the invention, there is provided seed and plants of the hybrid corn variety designated CH864601. The invention thus relates to the plants, seeds and tissue cultures of the variety CH864601, and to methods for producing a corn plant produced by crossing a corn plant of variety CH864601 with itself or with another corn plant, such as a plant of another variety. The invention further relates to genetic complements of plants of variety CH864601.
US08507768B1 Inbred maize variety PH11T4
A novel maize variety designated PH11T4 and seed, plants and plant parts thereof. Methods for producing a maize plant that comprise crossing maize variety PH11T4 with another maize plant. Methods for producing a maize plant containing in its genetic material one or more traits introgressed into PH11T4 through backcross conversion and/or transformation, and to the maize seed, plant and plant part produced thereby. Hybrid maize seed, plant or plant part produced by crossing the variety PH11T4 or a locus conversion of PH11T4 with another maize variety.
US08507767B1 Inbred corn line NPFX4376
Basically, this invention provides for an inbred corn line designated NPFX4376, methods for producing a corn plant by crossing plants of the inbred line NPFX4376, with plants of another corn plant. The invention relates to the various parts of inbred NPFX4376, including culturable cells. This invention also relates to methods for introducing transgenic transgenes into inbred corn line NPFX4376, and plants produced by said methods.
US08507766B1 Soybean cultivar S110140
A soybean cultivar designated S110140 is disclosed. The invention relates to the seeds of soybean cultivar S110140, to the plants of soybean cultivar S110140, to the plant parts of soybean cultivar S110140, and to methods for producing progeny of soybean cultivar S110140. The invention also relates to methods for producing a soybean plant containing in its genetic material one or more transgenes and to the transgenic soybean plants and plant parts produced by those methods. The invention also relates to soybean cultivars or breeding cultivars, and plant parts derived from soybean cultivar S110140. The invention also relates to methods for producing other soybean cultivars, lines, or plant parts derived from soybean cultivar S110140, and to the soybean plants, varieties, and their parts derived from use of those methods. The invention further relates to hybrid soybean seeds, plants, and plant parts produced by crossing cultivar S110140 with another soybean cultivar.
US08507762B2 Soybean variety A1024315
The invention relates to the soybean variety designated A1024315. Provided by the invention are the seeds, plants and derivatives of the soybean variety A1024315. Also provided by the invention are tissue cultures of the soybean variety A1024315 and the plants regenerated therefrom. Still further provided by the invention are methods for producing soybean plants by crossing the soybean variety A1024315 with itself or another soybean variety and plants produced by such methods.
US08507760B2 Wild rocket cultivar Tricia
A wild rocket cultivar, designated Tricia, is disclosed. The invention relates to the seeds of wild rocket cultivar Tricia, to the plants of wild rocket cultivar Tricia and to methods for producing a wild rocket plant by crossing the cultivar Tricia with itself or another wild rocket cultivar. The invention further relates to methods for producing a wild rocket plant containing in its genetic material one or more transgenes and to the transgenic wild rocket plants and plant parts produced by those methods. This invention also relates to wild rocket cultivars or breeding cultivars and plant parts derived from wild rocket cultivar Tricia, to methods for producing other wild rocket cultivars, lines or plant parts derived from wild rocket cultivar Tricia and to the wild rocket plants, varieties, and their parts derived from the use of those methods. The invention further relates to hybrid wild rocket seeds, plants, and plant parts produced by crossing cultivar Tricia with another wild rocket cultivar.
US08507755B2 Methods for altering the reactivity of plant cell walls
Methods and means are provided for the modification of the reactivity of plant cell walls, particularly as they can be found in natural fibers of fiber producing plants by inclusion of positively charged oligosaccharides or polysaccharides into the cell wall. This can be conveniently achieved by expressing a chimeric gene encoding an N-acetylglucosamine transferase, particularly an N-acetylglucosamine transferase, capable of being targeted to the membranes of the Golgi apparatus in cells of a plant.
US08507754B2 Engineering lipids in vegetative tissues of plants
The present invention discloses gene targets and methods for the genetic control of lipid accumulation in vegetative (non-seed) portions of plants. Enhanced lipid, e.g. triacylglycerol (TAG), accumulation in vegetative portions of plants may be obtained by down-regulation of activity of At4g24160 or a homolog thereof. Plants, plant parts, seeds comprising down-regulated AT4G24160 activity, or activity of a homolog thereof, are also provided, as well as products prepared therefrom.
US08507753B2 Plants having enhanced yield-related traits and a method for making the same
The present invention relates generally to the field of molecular biology and concerns a method for enhancing various economically important yield-related traits in plants. More specifically, the present invention concerns a method for enhancing yield-related traits in plants by modulating expression in a plant of a nucleic acid encoding a NITR (Nitrite Reductase) polypeptide or an ASNS (Asparagine Synthase) polypeptide. The present invention also concerns plants having modulated expression of a nucleic acid encoding a NITR polypeptide or an ASNS polypeptide, which plants have enhanced yield-related traits relative to control plants. The invention also provides constructs comprising NITR-encoding nucleic acids or ASNS-encoding nucleic acids, useful in performing the methods of the invention.
US08507752B1 Maize variety hybrid X13B662
A novel maize variety designated X13B662 and seed, plants and plant parts thereof, produced by crossing Pioneer Hi-Bred International, Inc. proprietary inbred maize varieties. Methods for producing a maize plant that comprises crossing hybrid maize variety X13B662 with another maize plant. Methods for producing a maize plant containing in its genetic material one or more traits introgressed into X13B662 through backcross conversion and/or transformation, and to the maize seed, plant and plant part produced thereby. This invention relates to the maize variety X13B662, the seed, the plant produced from the seed, and variants, mutants, and minor modifications of maize variety X13B662. This invention further relates to methods for producing maize varieties derived from maize variety X13B662.
US08507749B2 Transgenic chickens producing exogenous protein in eggs
This invention provides vectors and methods for the stable introduction of exogenous nucleic acid sequences into the genome of a bird and for expressing said exogenous sequences to alter the phenotype of the bird or to produce desired proteins. In particular, transgenic chickens are produced which express exogenous sequences in their oviducts. Eggs which contain exogenous proteins are also produced.
US08507748B2 Method for the production of a single heavy chain antibody
The present invention relates to a method for the generation of single chain immunoglobulins in a mammal. In particular, the present invention relates to a method for the generation of single chain camelid VHH antibodies in a mammal which undergo the process of class-switching and affinity maturation found within antibody producing B cells. Single chain antibodies generated using the method of the present invention and the uses thereof are also described.
US08507746B2 Leakage-signaling absorbent article
An absorbent article for preventing leakage is provided, the article including an absorbent assembly having an absorbent assembly perimeter, and a leakage warning element disposed adjacent a portion of the perimeter, wherein the leakage warning element includes a dimension change member adapted to dimensionally change upon liquid contact to produce a transition in the absorbent article between an activated state and an un-activated state, thereby producing a physical sensation indicating a fullness level of the absorbent assembly. The absorbent article also provides an absorbent assembly having an absorbent assembly perimeter and a leakage warning element including a stored energy device and a dimension change member, the dimension change member disposed along a portion of the perimeter, wherein the dimension change member is adapted to break upon liquid contact to produce a transition in the leakage warning element from an un-activated state to an activated state.
US08507740B2 Biorefinery method
The invention relates to a method for producing a petrochemical product from biomass, involving the following steps: dewatering and drying biomass; producing crude oil by the direct liquefaction of the dried biomass; hydrogenating the crude oil into hydrocarbons; and refining the hydrocarbons into a petrochemical product. Said method is characterized in that the hydrogen used for hydrogenating the crude oil is obtained from the wastewater accumulated during the dewatering and drying of the biomass and/or during the direct liquefaction and from the residue accumulated during the direct liquefaction.
US08507735B2 Alcohol synthesis
A process is disclosed for the production of alcohols including ethanol, propanol and butanol starting with lower molecular weight alcohol, which is reacted with carbon monoxide to give an organic acid that in turn is reduced with hydrogen to form the product.
US08507732B2 Purification of tris-hydroxyaryl compounds
The present invention is directed to a composition comprising a tris-hydroxyaryl compound having a metal ion impurity content of less than 10 ppm and to a process for the purification of tris-hydroxyaryl compound having a metal ion impurity, comprising at least the following steps: a) conditioning a sulphonic acid group-containing active ion exchanger with a solvent which is suitable for the handling of the tris-hydroxyaryl compounds, b) producing a solution of the tris-hydroxyaryl compounds to be purified in a solvent which is suitable for the handling of the tris-hydroxyaryl compounds, c) contacting the tris-hydroxyaryl compound-containing solution from b) with the conditioned ion exchanger from a), d) separating the tris-hydroxyaryl compound-containing solution from c) from the conditioned ion exchanger, e) removing at least part of the solvent from the solution of the tris-hydroxyaryl compound separated in d) under low temperature stress.
US08507731B2 Hydroformylation process using a symmetric bisphosphite ligand for improved control over product isomers
A process for hydroformylating an α-olefin to produce two or more aldehydes comprising a normal aldehyde and one or more iso-aldehydes with a target molar ratio of the normal aldehyde to one or more iso-aldehydes in a selectable range from 3/1 to 60/1. The process uses a transition metal-ligand complex catalyst comprising a symmetric calixarene bisphosphite ligand. The target N/I ratio is selected by controlling carbon monoxide partial pressure.
US08507729B2 Cyclohexanone production process with multiple post-distillation
The present invention relates to a method for continuously preparing cyclohexanone from phenol making use of a catalyst comprising at least one catalytically active metal selected from platinum and palladium comprising hydrogenating phenol to form a product stream comprising cyclohexanone and unreacted phenol; separating at least part of the product stream, or at least part of the product stream from which one or more components having a lower boiling point than cyclohexanone have been removed, into a first fraction comprising cyclohexanone and a second fraction comprising phenol and cyclohexanol, using distillation; separating the second fraction into a third fraction, rich in cyclohexanol, and a fourth fraction, rich in phenol, using distillation; —subjecting at least part of the fourth fraction to a further distillation step, thereby forming a fifth fraction and a sixth fraction, wherein the fifth fraction is enriched in phenol compared to the sixth fraction, and wherein the sixth fraction comprises side-products having a higher boiling point than phenol, and phenol; and which method is characterized in the additional step of continuously or intermittently separating at least part of the sixth fraction to yet a further distillation step, thereby forming a seventh fraction and an eight fraction, wherein the seventh fraction is enriched in phenol compared to the eight fraction, and wherein the eight fraction comprises side-products having a higher boiling point than phenol.
US08507727B2 Method for producing cyclohexyl alkyl ketones
Provided is an industrially superior method for producing cyclohexyl alkyl ketones, which solves the problems in process reduction and in disposal of wastes such as metals.An aromatic ketone represented by a formula (1) is nuclear-hydrogenated with pressurized hydrogen and in the presence of a solvent at a temperature of from 20 to 120° C., in the presence of a catalyst that carries from 0.1 to 20% by weight of a ruthenium atom on the carrier, thereby producing a cyclohexyl alkyl ketone represented by a formula (2): provided that, in the formula (2), n indicates an integer of from 1 to 3; R represents a hydroxyl group, a cyclohexyl group, an alkyl group having from 1 to 4 carbon atoms, or an acyl group having from 1 to 4 carbon atoms
US08507724B2 Compounds for use in the treatment of pain
The present invention concerns compounds derived from the anaethetic propofol. The compounds may be useful in the treatment of pain, particularly, but not exclusively, chronic pain and central pain sensitisation.
US08507720B2 Titania-alumina supported palladium catalyst
A catalyst comprising palladium supported on a titania-alumina extrudate is disclosed. The extrudate comprises at least 80 wt % titania and 0.1 to 15 wt % alumina. A palladium catalyst prepared from the titania-alumina extrudate has significantly higher crush strength. Its catalytic performance in vinyl acetate production is improved.
US08507719B2 Crystalline solid and amorphous forms of (−)-halofenate and methods related thereto
The present invention provides crystalline solid and amorphous forms of (−)-halofenate. The crystalline solid forms may be used in various pharmaceutical compositions, and are particularly effective for the prevention and/or treatment of conditions associated with blood lipid deposition in a mammal, particularly those diseases related to Type 2 diabetes and hyperlipidemia. The invention also relates to a method for preventing or treating Type 2 diabetes and hyperlipidemia in a mammal comprising the step of administering a therapeutically effective amount of crystalline solid and amorphous forms of (−)-halofenate.
US08507718B2 Ketocarboxylic acids, methods of manufacture and uses thereof
Ketocarboxylic acids such as levulinic acid can be efficiently purified in high yield by esterification with a hydrocarbon polyol to the corresponding polyketocarboxylic ester, which can be readily purified, for example recrystallized. After purification, the ketocarboxylic ester can be hydrolyzed to provide pure ketocarboxylic acid, or a salt thereof, after removal of the esterifying hydrocarbon polyol, or used for other synthetic transformations. Advantageously, the polyketocarboxylic esters, ketocarboxylic acids, and salts thereof produced by this method are obtained in high purity.
US08507705B2 C2-symmetrical ruthenocene diphosphine ligands only with surface chirality and their manufacture
The invention affords C2-symmetrical ruthenocene diphosphine ligands with surface chirality and their manufacture. The present invention uses (S)-(S)-1,1′-2(diphenylphosphino)-2,2′-2[(S)-4-isopropyloxazolinyl] ruthenocene as raw material and the product is prepared through two or three steps of reaction. At the action of trifluoroacetic acid, (S)-(S)-1,1′-2(diphenylphosphino)-2,2′-2[(S)-4-isopropyloxazolinyl] ruthenocene first removes oxazoline and gets ester amides compound which then carries out ester exchange or reduction alkylation and gets the product of ruthenocene diphosphine ligand with surface chirality. The ligands prepared with the structure as follows from the invention can be used in all kinds of metallic catalysis asymmetric reaction and has good reaction activity and stereoselectivity, wherein R is methyl or ethyl, R1 is linear or branched alkyl, cycloalkyl, alkoxy, aryl, aralkyl and alkyl amino.
US08507704B2 Liquid composition containing aminoether for deposition of metal-containing films
A formulation, comprising: a) at least one metal-ligand complex, wherein one or more ligands are selected from the group consisting of β-diketonates, β-ketoiminates, β-ketoesterates, β-diiminates, alkyls, carbonyls, alkyl carbonyls, cyclopentadienyls, pyrrolyls, alkoxides, amidinates, imidazolyls, and mixtures thereof; and the metal is selected from Group 2 to 16 elements of the Periodic Table of the Elements; and, b) at least one aminoether selected from the group consisting of R1R2NR3OR4NR5R6, R1OR4NR5R6, O(CH2CH2)2NR1, R1R2NR3N(CH2CH2)2O, R1R2NR3OR4N(CH2CH2)2O, O(CH2CH2)2NR1OR2N(CH2CH2)2O, and mixtures thereof, wherein R1-6 are independently selected from group consisting of C1-10 linear alkyl, C1-10 branched alkyl, C1-10 cyclic alkyl, C6-C10 aromatic, C1-10 alkylamine, C1-10 alkylaminoalkyl, C1-10 ether, C4-C10 cyclic ether, C4-C10 cyclic aminoether, and mixture thereof.
US08507702B2 Continuous production of bioderived esters via supercritical solvent processing using solid heterogeneous catalysts
A method for the continuous production of ester based organic compounds from renewable natural products via supercritical solvent processing in the presence of heterogeneous nano-structured catalysts. Fatty acid triglycerides may therefore be transesterified using heterogeneous nano-structured catalysts in the presence of supercritical alcohols to provide alkyl ester compounds and glycerine.
US08507698B2 Artemisinin derivatives for the treatment of melanoma
The invention relates to Artemisinin derivatives of general formula (I) wherein A and B are as defined in the specification. Compounds (I) have proved able to inhibit cell proliferation, in particular of uveal melanoma cells, and can therefore be used, either alone or in association with other antitumoral drugs, for the preparation of medicaments intended for the treatment of malignant melanoma.
US08507696B2 Intermediates in the synthesis zearalenone macrolide analogs
Disclosed herein are methods and intermediates useful in the preparation of macrolides, e.g., compounds of formula (IV), wherein R1-R12 are as defined herein.
US08507694B2 Process for the preparation of pyrazole carboxylic acid amides
The invention relates to a process for the preparation of 3-difluoromethyl-1-methyl-1H-pyrazole-4-carboxylic acid (9-dichloromethylene-1,2,3,4-tetrahydro-1,4-methano-naphthalen-5-yl)-amide.
US08507689B2 Organic salt compound, and optical recording material and optical recording medium using the organic salt compound
Compounds of the class of organic salts based on monomethine cyanine cation and azomethine complex cation are useful to promote light sensitivity and light resistance in laser writable and readable recording material. The compounds of Formula (I) and (IV) are exemplified in Formula (I) with X being oxygen, sulfur, or selenium; R1 and R2 are each C1-C20 alkyl, C7-C30 arylalkyl; R3 to R6 are each hydrogen, C1-C20 alkyl, etc.; R4 and R5 may be taken together to form a 6-membered ring; Y1 and Y2 are each C1-C20 alkyl; R7 to R10 are each hydrogen, C1-C20 alkyl, etc.; and adjacent two of R7 to R10 may be taken together to form a 5- or 6-membered ring. In Formula (IV) M′ is Fe, Co, Ni, Cr or Mn; and R11 to R26 are each hydrogen, nitro, —NRR′ (R and R′ are each C1-C4 alkyl).
US08507675B2 Compositions and methods for inhibition of the JAK pathway
Disclosed are compounds of formula I, compositions containing them, and methods of use for the compounds and compositions in the treatment of conditions in which modulation of the JAK pathway or inhibition of JAK kinases, particularly JAK 2 and JAK3, are therapeutically useful.
US08507669B2 Optically active dibenzazepine derivatives
It is to provide a novel optically active dibenzazepine derivative having a high utility value as an asymmetric phase-transfer catalyst. It is an optically active 6,7-dihydro-5H-dibenzo[c,e]azepine derivative represented by the following formula (1′), (wherein R represents a divalent organic group for cross-linking the 1st position and the 11th position; R1 and R2 are the same or different, and represent a hydrogen atom, halogen atom, or organic group, or R1 and R2 together represent a divalent organic group; R3′ and R4′ are the same or different and represent a monovalent organic group, or R3′ and R4′ together form an organic group that forms a cyclic structure comprising an onium nitrogen atom; Ar represents a monovalent organic group; * represents optical activity, i.e., that one axially asymmetric isomer is present in excess of the other axially asymmetric isomer with respect to a bond axis that constitutes the biphenyl structure of the compound; and X− represents a counter anion).
US08507666B2 Modification of carbohydrates using continuous generation of hydroxyl radicals
Disclosed herein are methods for modifying carbohydrates using hydroxyl radicals. The hydroxyl radicals may be formed by the photolysis of peroxide in aqueous solution using UV light. Also disclosed are compositions and products comprising carbohydrates modified by the process.
US08507659B2 Method for chemically modifying biopolymer and polypeptide
It is an object of the present invention to provide a method for chemically modifying biopolymer and polypeptide with a hydrophobic compound or a compound which causes degradation or reaction under basic condition. The present invention provides a method for producing a chemically modified biopolymer or polypeptide, wherein a biopolymer or polypeptide is chemically modified in a reaction solution containing an organic fluorine compound.
US08507658B2 Ex vivo animal or challenge model as method to measure protective immunity directed against parasites and vaccines shown to be protective in the method
Described are antibodies specifically directed against a cathepsin-like protease that are specific for newly excysted juvenile (NEJ) stages of Fasciola hepatica. Diagnostic tests wherein such antibodies are detected or used are also provided.
US08507656B2 Stabilized angiopoietin-2 antibodies and uses thereof
Stabilized antibodies directed to Angiopoeitin-2 and uses of such antibodies are described. Nucleic acid and amino acid sequences, hybridomas or other cell lines for expressing such antibodies are also provided.
US08507655B2 Antibody against anthrax toxins
The invention relates to an anti PA antibody, in which the variable region of the heavy chain has an amino acid sequence represented by SEQ ID N°1 and in which the variable sequence of the light chain has an amino acid sequence represented by SEQ ID N°2, that is modified in order to improve its affinity and its tolerance in human beings.
US08507650B2 Use of bacteriophage outer membrane breaching proteins expressed in plants for the control of gram-negative bacteria
The present invention provides compositions and methods for killing or suppressing growth of Gram-negative bacteria that infect, infest or cause disease in plants, including pathogenic, saprophytic and opportunistic microbes that cause disease in plants and food borne illness in people or in animal feed.
US08507644B2 Method of making a metal terephthalate polymer
Methods of making metal-terephthalate polymers from a polyester ethylene terephthalate or terephthalic acid produces high yield and high purity reaction products for a range of metals. Among the preferred metal compounds employed in the processes are metal oxides and metal hydroxides. The methods are preferably carried out at a low pressure and can produce metal-terephthalate polymer powders containing small crystals which can be employed to enhance properties of polymers or disperse metals in specific applications by thermal decomposition of metal-terephthalate polymers.
US08507643B2 Composition comprising glycerol, process for obtaining same and use thereof in the manufacture of dichloropropanol
A composition comprising glycerol and at least one cyclic oligomer of glycerol, a process for obtaining the composition, and its use in the manufacture of dichloropropanol and of derived products such as epichlorohydrin and epoxy resins.
US08507636B2 High molecular weight poly(2,6-dimethyl-1,4-phenylene ether) and process therefor
A poly(2,6-dimethyl-1,4-phenylene ether) having a high molecular weight and a reduced content of low molecular weight species can be prepared by a method that includes specific conditions for the oxidative polymerization, chelation, and isolation steps. The poly(2,6-dimethyl-1,4-phenylene ether) is particularly useful for the fabrication of fluid separation membranes.
US08507635B2 Modified polycarbonates having improved surface properties
The present invention relates to polycarbonates comprising imide-containing aryl mono- or dihydroxy compounds as chain terminators and, respectively, monomer units, and also to compositions comprising the said polycarbonates, to their use for the production of mouldings, and to mouldings obtainable therefrom.
US08507633B2 Thermoplastic polyurethanes
A process for the preparation of thermoplastic polyurethane by reacting (a) isocyanates with (b) compounds reactive toward isocyanates and having a molecular weight (Mw) of from 500 to 10 000 g/mol and (c) chain extenders having a molecular weight of from 50 to 499 g/mol, if appropriate in the presence of (d) catalysts and/or (e) conventional additives, wherein the chain extender mixture consisting of a main chain extender (c1) and one or more co-chain extenders (c2) is used and the thermoplastic polyurethane prepared has a rigid phase fraction of greater than 0.40, the rigid phase fraction being defined by the following formula: rigid ⁢ ⁢ phase ⁢ ⁢ fraction = { ∑ x = 1 k ⁢ [ ( m KVx / M KVx ) * M Iso + m KVx ] } / m ges with the following meanings: MKVx: molar mass of the chain extender x in g/mol mKVx: mass of the chain extender x in g MIso: molar mass of the isocyanate used in g/mol mges: total mass of all starting materials in g k: number of chain extenders.
US08507632B2 Composition curable with actinic energy ray and use thereof
An actinic energy ray curable composition useful as a paint or coating agent, especially for products where scratch resistance is desired, includes a particular composition that includes a urethane (meth)acrylate obtained by reacting to an organic isocyanate having a plurality of isocyanate groups in one molecule with a polycaprolactone-modified alkyl (meth)acrylate and a long-chain alcohol.
US08507629B2 Organic polymer containing two or more organic ring structures and a chain structure threading through the organic ring structures, and production method thereof
A production method of the present invention is a production method of an organic polymer containing two or more organic ring structures and a chain structure threading through the organic ring structures. This method includes a polymerization step of forming the organic polymer, in which the organic ring structures, which are restricted from moving, are disposed at each of a particular constitutional unit, by polymerizing at least one type of monomers each of which has no ionic functional group that releases a metal ion. The above at least one type of monomers include a monomer (M) containing the organic ring structure and a chain component threading through the organic ring structure.
US08507628B2 Propylene based polymers for injection stretch blow molding
Injection stretch blow molded (ISBM) articles and methods of forming the same are provided herein. In one embodiment, the ISBM articles generally include a propylene based random copolymer having a molecular weight distribution of from about 9 to about 20. In another embodiment, the ISBM articles generally include a propylene based random copolymer formed from a Ziegler-Natta catalyst including a succinate internal donor.
US08507622B2 Polymerizable compositions
The present invention relates to a process for providing improved low VOC polymerizable compositions containing phosphoalkyl (meth)acrylate monomers which are synthesized by the reaction of a hydroxyalkyl (meth)acrylate with polyphosphoric acid (PPA).
US08507621B2 Polymerization process for producing bimodal polymers
Catalyst compositions comprising a first metallocene compound, a second metallocene compound, an activator-support, and an organoaluminum compound are provided. An improved method for preparing cyclopentadienyl complexes used to produce polyolefins is also provided.
US08507616B2 Halo-free heat transfer label with pigmented adhesive
A pigmented adhesive, halo-free heat transfer label is created when adhesive properties are incorporated into colored inks used to print graphics on labels for items such as apparel. The resulting label has a halo-free graphic applied thereto that eliminates the need for a separate application of adhesive to the label. A pigmented adhesive composition for use with heat transfer type labels includes a hydroxyl-functional polyurethane dispersion, one or more polyurethane dispersions different from the hydroxyl-functional polyurethane dispersion, a blocked cross-linking agent, a catalyst for the blocked cross-linking agent, a pigment dispersion, and an adhesive powder, which are combined prior to the formation of a graphic created using the combined mixture, on the release layer of a substrate.
US08507615B2 Polyimide resins for high temperature wear applications
Polyimide resin compositions that contain an end-capped rigid aromatic polyimide, graphite and, optionally, a filler selected from sepiolite, attapulgite, kaolinite, or a mixture thereof, are found to exhibit low wear at high temperatures. Such compositions are especially useful in molded articles that are exposed to wear conditions at high temperatures such as aircraft engine parts.
US08507614B2 Multiphasic absorbable compositions of segmented l-lactide copolymers
Absorbable, multiphasic, crystalline, solid blend compositions having at least two first order thermal transitions, are formed of a segmented l-lactide copolymer as the principal or major component and at least one additional crystalline thermoplastic absorbable polyester having glycolide-based sequences, a fraction of which participated in ester-ester interchange reactions with lactide-based sequences to produce crystalline materials with modulated properties for use in producing orthopedic and tissue-repair devices.
US08507610B2 Modified polymer material modified by nitrile oxide, and production method thereof
The present invention provides a production method of a modified polymer material produced by modifying a polymer material having in a molecule thereof a multiple bond that reacts with a nitrile oxide, includes reacting the polymer material with an aromatic nitrile oxide derivative having a substituent at an ortho-position of a nitrile oxide group of an aromatic nitrile oxide in which the nitrile oxide group is bonded to an aromatic ring.
US08507605B2 Latex compositions and uses thereof
The present technology provides a latex comprising: a mixture of microgels and sol polymers of an acrylic copolymer, wherein the Mc of the acrylic copolymer is greater than or equal to the Me thereof; the Mw of the sol polymers is greater than or equal to twice the Me of the acrylic copolymer; the amount of sol polymer having a Mw less than twice the Me of the acrylic copolymer is about 20 wt % or less than 20 wt %. Such lattices may be used to form films for use as adhesives such as pressure sensitive adhesives. Also provided are methods for manufacturing the films and adhesives.
US08507598B2 Transparent polyamide moulding compound
The invention relates to polyamide molding compounds with improved scratch resistance, which are constructed from (A1) 50 to 99.99 parts by weight of a copolyamide, (A2) 0 to 49.99 parts by weight of a transparent polyamide, (A3) 0 to 29.99 parts by weight of an aliphatic polyamide, (B) 0.01 to 5 parts by weight of at least one lubricant, and (C) 0 to 3 parts by weight of further additives, with the proviso that the sum of (A1) and (A2) and (A3) and (B) produces 100 parts by weight.
US08507597B2 Polymeric defoamer additive
The present invention relates to a cost-effective and environmentally friendly polymeric defoamer formulation for use in various industrial applications that does not contain oil, EBS or free silicone.
US08507590B2 Fluorescent brighteners, methods of preparation thereof, fluorescent brightener compositions, and methods of preparation and uses thereof
A compound of Formula (I) wherein R1, R2, and R3 are independently at each occurrence hydrogen, a halogen, a cyano functionality, a C1-C20 aliphatic functionality, a C3-C10 cycloaliphatic functionality or a C3-C20 aromatic functionality, with the proviso that R2 and R3 are not hydrogen when R1 is a methyl or hydrogen; R4 and R5 are independently at each occurrence hydrogen, a halogen, a cyano functionality, a C1-C20 aliphatic functionality, a C3-C10 cycloaliphatic functionality or a C3-C10 aromatic functionality; R7 and R8 are independently at each occurrence, a halogen, a cyano functionality, a C1-C20 aliphatic functionality, a C3-C10 cycloaliphatic functionality or a C3-C10 aromatic functionality; R6 is a C2-C20 aliphatic functionality, a C3-C10 cycloaliphatic functionality or a C3-C20 aromatic functionality; and “n” and “m” are each independently integers having a value of 0 to 3.
US08507587B2 Lightweight wall repair compounds
Herein are disclosed wall repair compounds comprising at least one or more polymeric binder latex emulsions, one or more inorganic fillers, and comprising an amount of organic polymeric thickener that is less than about 0.1 percent by weight based on the total weight of the wall repair compound. In certain embodiments, the wall repair compound comprises an inorganic filler system selected such that such that synthetic inorganic fillers comprise essentially 100 percent of the inorganic filler used. In certain embodiments, the wall repair compound comprises one or more organic ether smoothing agents.
US08507585B2 Non-aqueous pigment ink
A non-aqueous pigment ink comprising a pigment, a non-aqueous solvent, and non-aqueous resin dispersion microparticles having a pigment dispersion capability, wherein the non-aqueous resin dispersion microparticles are an acrylic polymer comprising an alkyl (meth)acrylate unit having an alkyl group of 12 or more carbon atoms and a (meth)acrylate unit having a urethane group. The acrylic polymer is a copolymer of a monomer mixture comprising an alkyl (meth)acrylate (A) having an alkyl group of 12 or more carbon atoms and a reactive (meth)acrylate (B) having a functional group capable of reacting with an amino group, wherein the urethane group is introduced by a reaction between the functional group capable of reacting with an amino group, an amino alcohol and a polyvalent isocyanate compound, and the mass ratio within the acrylic polymer between the copolymer portion and the introduced urethane group portions is within a range from 60:40 to 99:1.
US08507581B2 Stone based copolymer substrate
A stone based copolymer substrate includes calcium carbonate (CaCO3) from approximately fifty to eighty-five percent (50-85%) by weight and varying in size generally from 1.0 to 3.0 microns, high-density polyethylene (HDPE) from approximately two to twenty-five percent (2-25%) by weight and a biopolymer from approximately two to twenty-five percent (2-25%) by weight. The substrate may include a biodegradation additive from approximately three fourths of a percent to two percent (0.75-2%) by weight. By selectively adjusting the ranges of the substrate's components, various products can be made to replace current tree-based and plastic-based products. The substrate can be configured to be tear proof, water proof, fade resistant and fire retardant while utilizing less energy and producing less waste during its manufacture. In an exemplary embodiment of the invention, the stone used in the substrate includes limestone.
US08507577B2 Process for forming clear, wettable silicone hydrogel articles
The present invention is a process for forming ophthalmic devices such as contact lenses, comprising the steps of curing a reactive mixture comprising at least one silicone-containing component, at least one hydrophilic component and at least one protonated diluent or protonatable diluent having a Hansen solubility parameter, δp between about 2 and about 7 to form an ophthalmic device having an advancing contact angle of less than about 80°; contacting the ophthalmic device with an aqueous solution which is capable of changing the Hansen solubility parameter, δp of the protonated or protonatable co-diluent to enhance water solubility and removing said diluent(s) with said aqueous solution.
US08507574B2 Zirconium oxide dispersion, photo-curing composition containing zirconium oxide particle, and cured film
The present invention provides a zirconium oxide dispersion which contains zirconium oxide particles, a metal complex, and a dispersion medium and which has excellent storage stability; a photo-curing composition containing zirconium oxide particles which contains zirconium oxide particles, a metal complex, an actinic energy ray-curing compound, a photopolymerization initiator, and a dispersion medium and which composition can form, on a surface of a substrate, a cured film having excellent transparency and high refractive index, and which composition does not corrode a metal-made apparatus employed in a dispersion process and a coating apparatus; and a cured film produced by applying onto a substrate the photo-curing composition containing zirconium oxide particles through coating or printing, followed by hardening.
US08507573B2 Active energy ray curable inkjet ink composition
There is provided an inkjet ink which has satisfactory storage stability and inkjet ejection stability, exhibits excellent curability, and is capable of forming high quality images on coated paper by an inkjet system. Disclosed is an active energy ray curable inkjet ink composition comprising: 15-75% by weight of at least one polymerizable bifunctional monomer selected from the group consisting of dipropylene glycol diacrylate and 1,9-nonanediol diacrylate; and 1% by weight to 10% by weight of [4-(methylphenylthio)phenyl]phenylmethanone as a photopolymerization initiator.
US08507564B2 Method for selecting perfume ingredient, method for formulating fragrance, and preference-enhancing agent
Methods for enhancing a preference for a product by repetitive use. The method involves formulating a perfume composition into a product, the perfume composition including (I) allyl caproate and (II) ambroxan or geranium oil.
US08507559B2 Cyclohexenyl modulators of chemokine receptor activity
The present application describes modulators of MCP-1 or CCR-2 of formula, (I) or stereoisomers or prodrugs or pharmaceutically acceptable salts thereof, wherein T, W, X, Y, Z, R1, R2, R4 and R6, are defined herein. In addition, methods of treating and preventing inflammatory diseases such as asthma and allergic diseases, as well as autoimmune pathologies such as rheumatoid arthritis and transplant rejection using modulators of formula, (I) are disclosed.
US08507558B2 Fatty acid treatment for cardiac patients
A method of treating patients in need of treatment for a cardiac disorder has been found which comprises administering to the patient a seven carbon fatty acid compound or derivative thereof, wherein the compound or derivative thereof is able to readily enter the mitochondrion without special transport enzymes. A dietary formulation suitable for treatment of heart tissue in cardiac or surgical patients has been found which comprises a seven-carbon fatty acid chain, wherein the seven-carbon fatty acid chain is characterized by the ability to transverse the inner mitochondrial membrane by a transport mechanism which does not require carnitine palmitoyltransferase I, carnitine palmitoyltransferase II, or carnitine/acylcarnitine translocase and the ability to undergo mitochondrial β-oxidation, and wherein the compound is selected from the group consisting of n-heptanoic acid or a derivative thereof, a triglyceride comprising n-heptanoic acid or a derivative thereof, and triheptanoin or a derivative thereof.
US08507557B2 Potentiators of insulin secretion
The present invention relates to a recognition that an analog of αKG can increase glucose-induced insulin secretion in vitro and in vivo in animals, particularly in mammals, and more particularly in humans and in rodents. By employing the methods of the invention, insulin secretion can be increased.
US08507556B2 Fluorescent particles comprising nanoscale ZnO layer and exhibiting cell-specific toxicity
A core-shell nanoparticle having a core that includes a fluorophore and a first oxide of a first metal and a shell that includes a second oxide of a second metal such that the first oxide and the second oxide are different. Also disclosed are methods relating to the core-shell nanoparticle.
US08507555B2 Non-toxic anti-cancer drug combining ascorbate, magnesium and a naphthoquinone
Compositions comprising combinations of magnesium ascorbate (magnesium Vitamin C of “MgVC2”) and Vitamin K3 or (VK3) or a quinone and semiquinone analogue of VK3, are used in methods for killing or inhibiting the growth of tumor or cancer cells or preneoplastic cells in a subject, or for treating cancer in a subject in need of such treatment.
US08507552B2 Triptolide prodrugs
The invention provides compounds of formula (I): or a salt thereof. The invention also provides pharmaceutical compositions comprising a compound of formula I, processes for preparing compounds of formula I, intermediates useful for preparing compounds of formula I and therapeutic methods using the compounds of formula I.
US08507551B2 Antimicrobial therapy for bacterial infections
The disclosure provides a molecular genetic approach of targeted mutagenesis and heterologous expression, coupled with in vitro and in vivo models of bacterial pathogenesis, to demonstrate that the S. aureus pigment is a virulence factor and potential novel target for antimicrobial therapy.
US08507547B2 Anti-fatigue agents and oral compositions containing andrographolide as active ingredient
Disclosed is a composition which is safe for a human body and an animal, can be ingested continuously on a daily basis, has an anti-fatigue activity, and is effective for the prevention or treatment of a disease or condition associated with fatigue. Specifically disclosed is an anti-fatigue agent comprising andrographolide optionally together with an α-lipoic acid as an active ingredient(s). Also disclosed is a novel oral composition comprising andrographolide and an α-lipoic acid. The anti-fatigue agent and the oral composition are useful for the prevention or treatment of chronic fatigue syndrome, overfatigue, physical fatigue, mental fatigue and organ fatigue.
US08507546B2 Use of inhibitors of scavenger receptor class proteins for the treatment of infectious diseases
The present invention relates to the use of inhibitors of scavenger receptor class proteins, in particular ScarB1 for the production of a medicament for treatment of and/or prophylaxis against infections, involving liver cells and/or hematopoietic cells, in particular malaria.
US08507543B2 Compounds
Indazole compounds, processes for their preparation, intermediates usable in these processes, pharmaceutical compositions containing such compounds and their use in therapy.
US08507538B2 Selective heterocyclic sphingosine 1 phosphate receptor modulators
Compounds that selectively modulate the sphingosine 1 phosphate receptor are provided including compounds which modulate subtype 1 of the S1P receptor. Methods of chiral synthesis of such compounds is provided. Uses, methods of treatment or prevention and methods of preparing inventive compositions including inventive compounds are provided in connection with the treatment or prevention of diseases, malconditions, and disorders for which modulation of the sphingosine 1 phosphate receptor is medically indicated.
US08507537B2 Trifluromethoxyphenyl-substituted tetramic acid derivatives pesticides and/or herbicides
The present invention relates to novel trifluoromethoxyphenyl-substituted tetramic acid derivatives of the formula (I), in which J, X, Y, A, B, D and G have the meanings given above, to a number of processes for their preparation, and to their use as pesticides and/or herbicides. The invention further provides selective herbicidal compositions which comprise, firstly, trifluoromethoxyphenyl-substituted tetramic acid derivatives and, secondly, a crop plant compatibility-improving compound. The invention further relates to the boosting of the action of crop protection compositions comprising compounds of the formula (I) through the additions of ammonium salts or phosphonium salts and optionally penetrants.
US08507533B2 Glucagon receptor modulators
The present invention provides a compound of Formula (I) or a pharmaceutically acceptable salt thereof wherein R1, R2, R3, A1, A2, A3, A4, L, B1, B2, B3 and B4 are as defined herein. The compounds of Formula I have been found to act as glucagon antagonists or inverse agonists. Consequently, the compounds of Formula I and the pharmaceutical compositions thereof are useful for the treatment of diseases, disorders, or conditions mediated by glucagon.
US08507532B2 Stable insecticide compositions and methods for producing same
Insect controlling compositions including an N-substituted (6-haloalkylpyridin-3-yl)alkyl sulfoximine compound exhibiting increased stability, along with methods for preparing same, are disclosed.
US08507530B2 Pyridine derivatives substituted by heterocyclic ring and phosphonoamino group, and anti-fungal agent containing same
Anti-fungal agent having excellent anti-fungal action physicochemical properties including safety and water solubility. Compound represented by formula (I), or salt thereof: wherein R1 represents hydrogen, halogen, amino, R11—NH— wherein R11 represents C1-6 alkyl, hydroxy C1-6 alkyl, C1-6 alkoxy C1-6 alkyl, or C1-6alkoxycarbonyl C1-6 alkyl, R12—(CO)—NH— wherein R12 represents C1-6 alkyl group or C1-6 alkoxy C1-6 alkyl, C1-6 alkyl, hydroxy C1-6 alkyl, cyano C1-6 alkyl, C1-6 alkoxy, or C1-6 alkoxy C1-6 alkyl or a phosphonoamino group; R2 represents hydrogen, C1-6 alkyl, amino, or a di C1-6 alkylamino group or a phosphonoamino group; one of X and Y is nitrogen while the other is nitrogen or oxygen; ring A represents a 5- or 6-member heteroaryl ring or a benzene ring which may have a halogen atom or 1 or 2 C1-6 alkyl groups; Z represents a single bond, a methylene group, an ethylene group, oxygen, sulfur, —CH2O—, —OCH2—, —NH—, —CH2NH—, —NHCH2—, —CH2S—, or —SCH2—; R3 represents hydrogen or halogen or C1-6 alkyl, C3-8 cycloalkyl, C6-10 aryl, a 5- or 6-member heteroaryl group or a 5- or 6-member nonaromatic heterocyclic group which may have 1 or 2 substituents; and R4 represents hydrogen or halogen; provided that either R1 or R2 represents a phosphonoamino group.
US08507526B2 4- [2- (4-methylphenylsulfanyl) phenyl] piperidine for the treatment of irritable bowel syndrome (IBS)
The use of 4-[2-(4-methylphenylsulfanyl)phenyl]piperidine or a pharmaceutically acceptable salt thereof in the treatment of irritable bowl syndrome.
US08507523B2 Therapeutic tetrahydroisoquinoline-based compositions for cancer therapy
Disclosed are therapeutic tetrahydroisoquinoline compositions for the treatment of cancer, these compositions having selectivity for cancer cells while demonstrating few, if any, deleterious side effects on normal cells.
US08507521B2 Heterocyclic derivatives
The present invention relates to a heterocyclic derivative of formula (I) wherein the variables are as defined in the specification, or to a pharmaceutically acceptable salt or solvate thereof. The present invention further relates to pharmaceutical compositions comprising said heterocyclic derivatives and to their use in therapy, for instance in the treatment or prevention of disorders mediated by glutamate dysfunction, such as schizophrenia and generalised anxiety disorder.
US08507519B2 Antibacterial optically pure benzoquinolizine carboxylic acids, processes, compositions and methods of treatment
The present invention relates to optically pure S-(−)-benzoquinolizine carboxylic acid, lysine salt and to pharmaceutical compositions comprising the S(−)-benzoquinolizine carboxylic acid, lysine salt.
US08507515B2 Crystalline form G of imatinib mesylate
Crystalline forms of imatinib mesylate (F, G, H, I and K) and their respective characterization are disclosed.
US08507514B2 Hydrazide compound and use of the same in pest control
There is provided a hydrazide compound having a controlling effect on pests represented by the formula (1): wherein, G is a 5-membered heterocyclic group, M is an oxygen atom or a sulfur atom, Q1, Q2, Q3 and Q4 is independently a nitrogen atom, etc., m is an integer of 0 to 5, R2 is an optionally halogenated C1-C6 alkyl group, etc., R5 and R6 are independently an optionally substituted C1-C12 chain hydrocarbon group, etc., and R4 is an optionally substituted C1-C12 chain hydrocarbon group, etc.
US08507512B2 Soluble guanylate cyclase activators
This inventions relates to compounds having the structure Formula I and pharmaceutically acceptable salts thereof which are soluble guanylate cyclase activators. The compounds are useful for treatment or prevention of cardiovascular diseases, endothelial dysfunction, diastolic dysfunction, atherosclerosis, hypertension, pulmonary hypertension, angina pectoris, thromboses, restenosis, myocardial infarction, strokes, cardiac insufficiency, pulmonary hypertonia, erectile dysfunction, asthma bronchiale, chronic kidney insufficiency, diabetes, or cirrhosis of the liver.
US08507511B2 Inhibitors of protein kinases
The present invention relates to inhibitors of cyclin-dependent kinases and therapeutic applications thereof. Furthermore, the invention relates to methods of preventing and/or treating any type of pain, inflammatory disorders, immunological diseases, proliferative diseases, infectious diseases, cardiovascular diseases and neurodegenerative diseases comprising the administration of an effective amount of at least one inhibitor of cyclin-dependent kinases. formula (I).
US08507507B2 Modulators of toll-like receptors
The present application includes novel modulators of TLRs, compositions containing such compounds, therapeutic methods that include the administration of such compounds.
US08507505B2 Dihydropyrazolopyrimidinone derivative
The present invention relates to a compound of General Formula (I) below, among others. In the Formula, Ar1 is an optionally substituted aryl or heteroaryl group; R1 is a hydrogen atom, an optionally substituted C1-C6 alkyl group, or an optionally substituted aryl, aralkyl, or heteroaryl group; R2 is an optionally substituted aryl, aralkyl, or heteroaryl group; and R3 is a hydrogen atom or a C1-C6 alkyl group. A compound of the present invention has an excellent Wee1 kinase inhibiting effect, and is therefore useful in the filed of medicine, particularly in various types of cancer therapy.
US08507502B2 Fused bicyclic and tricyclic pyrimidine compounds as tyrosine kinase inhibitors
Fused bicyclic or tricyclic compounds of formula (I): wherein A, B, C, X, Y, m, and n are defined herein. Also disclosed are a method for inhibiting EGFR kinase activity and a method for treating cancer with these compounds.
US08507497B2 Capped pyrazinoylguanidine sodium channel blockers
Provided is a method of treating cystic fibrosis in which an effective amount of a compound represented by formula (I) is administered to a subject in need thereof: where the structural variables are as defined herein.
US08507495B2 Sensitizer, kit and use for cancer therapy
A cancer therapy sensitizer is disclosed. The cancer therapy sensitizer includes rapamycin and substituted quinoline. The present invention discloses a cancer therapy sensitization kit containing the two aforementioned compounds and a use of a combination of the two aforementioned compounds as a cancer therapy sensitizer as well. The application of the cancer therapy sensitizer, the kit and the use of the present invention is advantageous for improving the treatment effect of cancer therapies.
US08507488B2 Fused nitrogen containing heterocycles and compositions thereof as kinase inhibitors
The invention provides compounds, pharmaceutical compositions comprising such compounds and methods of using such compounds to treat or prevent diseases or disorders associated with abnormal or deregulated kinase activity, particularly Ros, KDR, FMS, C-FMS, FLT3, c-Kit, JAK2, JAK3, Aurora, PDGFR, Lck, TrkA, TrkB, TrkC, IGF-IR, ALK4, ALK5 and ALK or combinations thereof.
US08507485B2 Cyclic compound having pyrimidinylalkylthio group
A method of treating a disease associated with angiogenesis by administering a therapeutically effective amount of a compound represented by the formula (1) or a salt thereof wherein the ring X represents R1 and R2 independently represent a hydrogen atom, an alkyl, an aryl or an aromatic heterocyclic; R3 represents a hydrogen atom, a halogen atom, a hydroxy, an alkoxy, an aryloxy, an alkyl, an aryl, an amino, an alkylamino, a cycloalkylamino, an arylamino, an alkylcarbonylamino, an arylcarbonylamino, a mercapto, an alkylthio, an arylthio, an alkylsulfinyl or a nonaromatic heterocyclic; A1 represents a sulfur atom, a sulfinyl or a sulfonyl; and A2 represents an alkylene.
US08507482B2 Bicyclic amide derivatives for enhancing glutamatergic synaptic responses
This invention relates to compounds, pharmaceutical compositions and methods for use in the prevention and treatment of cerebral insufficiency, including enhancement of receptor functioning in synapses in brain networks responsible for basic and higher order behaviors. These brain networks, which are involved in cognitive abilities related to memory impairment, such as is observed in a variety of dementias, in imbalances in neuronal activity between different brain regions, as is suggested in disorders such as Parkinson's disease, schizophrenia, sleep apneas, attention deficit hyperactivity disorder and affective or mood disorders, and in disorders wherein a deficiency in neurotrophic factors is implicated, as well as conditions such as stroke-induced central sleep apnea, obstructive sleep apnea, congenital hypoventilation syndrome, among others. In a particular aspect, the invention relates to bicyclic amide compounds useful for treatment of such conditions, and methods of using these compounds for such treatment.
US08507480B2 Isoxazole compounds as inhibitors of heat shock proteins
Isoxazoles of formula (A) or (B) are inhibitors of HSP90 activity, and useful for treatment of, for example cancers: wherein R1, is a group of formula (IA): —Ar1-(Alk1)p-(Z)r-(Alk2)s-Q, wherein in any compatible combination Ar1 is an optionally substituted aryl or heteroaryl radical, Alk1 and Alk2 are optionally substituted divalent C1-C6 alkylene or C2-C6 alkenylene radicals, p, r and s are independently 0 or 1, Z is -0-, —S—, —(C═O)—, —(C═S)—, —SO.sub.2-, —C(═O)O—, —C(═O)NRA—, —C(═S)NRA—, —SO2NRA—, —NRAC(═O)—, —NRASO2—or —NRA— wherein RA is hydrogen or C1-C6 alkyl, and Q is hydrogen or an optionally substituted carbocyclic or heterocyclic radical; R2 is (i) a group of formula (IA) above or (ii) a carboxamide radical; or (iii) a non aromatic carbocyclic or heterocyclic ring wherein a ring carbon is optionally substituted, and/or a ring nitrogen is optionally substituted by a group of formula -(Alk1)p-(Z)r-(Alk2)s-Q wherein Q, Alk1, Alk2, Z, p, r and s are as defined above in relation to group (IA); and R3 is hydrogen, optionally substituted cycloalkyl, cycloalkenyl, C1-C6 alkyl, C1-C6 alkenyl, or C1-C6 alkynyl; or a carboxyl, carboxamide, or carboxyl ester group.
US08507478B2 Oxazolidinyl antibiotics
The invention relates to antibacterial compounds of formula I wherein R1 is alkoxy or halogen; U and V each independently are CH or N; is a bond or is absent; W is CH or N or, when is absent, W is CH2 or NH, with the proviso that U, V and W are not all N; A is a bond or CH2; R2 is H or, provided A is CH2, may also be OH; m and n each independently are 0 or 1; D is CH2 or a bond; G represents a phenyl group substituted once or twice in the meta and/or para position(s) by substituents selected from alkyl, (C1-C3)alkoxy and halogen, or G is a group G1 or G2 wherein Z1, Z2 and Z3 may each represent CH or N; X is N or CH and Q is O or S; it being understood that if m and n each are 0, then A is CH2; and salts of such compounds.
US08507477B2 3- and 6-quinolines with N-attached heterocyclic CGRP receptor antagonists
Compounds of Formula (I): (where variables R1A, R1B, R2, R3, R4, A, and Z are as defined herein) which are useful as antagonists of CGRP receptors, and useful in the treatment or prevention of diseases in which CGRP receptors are involved, such as headache, and in particular migraine and cluster headache. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of such diseases in which CGRP receptors are involved.
US08507475B2 Substituted heteroarylamide diazepinopyrimidone derivatives
The disclosure relates to a series pyrimidone derivatives represented by formula (I) or a salt thereof, or a solvate thereof or a hydrate thereof: wherein: Y, Z, R1, R2, R3, R4, R5 and n are as defined in the disclosure. Also disclosed are methods of preparing the compounds of formula (I), intermediates therefor and their utility in treating a variety of disease conditions.
US08507467B2 Transdermally absorbable preparation
A transdermally absorbable preparation comprises a natural type sex hormone, a polyoxyethylene oleyl ether having a molar number of ethylene oxide units added of 20, at least two kinds of oily ingredients selected from the group consisting of diisopropyl adipate, cetyl alcohol, benzyl alcohol, and propylene glycol dicaprate, a polyhydric alcohol, and ethanol.
US08507466B2 Oils enriched with diacylglycerols and phytosterol esters and unit dosage forms thereof for use in therapy
Described herein are various lipid mixtures, more particularly special mixtures of fatty acids esters, which may be phytosterol esters and/or glyceride esters. Said mixtures are evaluated in the context of their ability to, upon consumption, affect the levels of circulating LDL and HDL particles, and their therapeutic effect on conditions associated with lipid metabolism, such as atherosclerosis, diabetes, metabolic disorders, etc. Compositions, dietary nutrients, food supplements and nutraceuticals comprising the herein described mixtures are also described.
US08507464B2 Phosphoramidate alkylator prodrugs
Phosphoramidate alkylator prodrugs can be used to treat cancer when administered alone or in combination with one or more anti-neoplastic agents.
US08507460B2 Substituted 3′,5′-cyclic phosphates of purine nucleotide compounds and pharmaceutical compositions for the treatment of viral infections
Provided herein are compounds, compositions and methods for the treatment of Flaviviridae infections, including HCV infections. In certain embodiments, compounds and compositions of nucleoside derivatives are disclosed, which can be administered either alone or in combination with other anti-viral agents.
US08507459B2 Use of adenosine aspartate for the preparation of pharmaceutical products for the treatment of liver cancer
The present invention relates to the novel use of an adenosine aspartate product for the formulation of a drug intended to prevent the development of preneoplastic lesions and to reverse some types of cancer, particularly liver cancer, providing chemoprotection, preventing myelotoxic effects.
US08507458B2 System for delivering nucleic acids for suppressing target gene expression by utilizing endogenous chylomicron
The object of present invention is to provide a system that can deliver in vivo nucleic acids such as an siRNA for suppressing a target gene expression in vivo more safely and efficiently, and to provide an expression-suppressing agent and a pharmaceutical composition utilizing the system. An introduction substance into chylomiclon, particularly nucleic acids to which an alpha-tocopherol is bound for suppressing a target gene expression, can be delivered more safely and efficiently into hepatic cells in vivo by administering the nucleic aids under the condition where the production of chylomicron is induced in the body. Alternatively, alpha-tocopherol-bound nucleic acids are mixed with extracted chylomiclon, and then they are administered. Consequently, a target gene expression is suppressed, thereby a disease caused by an elevated expression of the target gene can be treated more safely and efficiently.
US08507457B2 Compositions for conferring tolerance to viral disease in social insects, and the use thereof
Compositions and methods for reducing susceptibility to infectious disease in bees using RNA interference technology, and more particularly, prevention and treatment of viral infections in honeybees such as Israel acute paralysis virus (IAPV) by feeding of pathogen-specific dsRNA. Further, multiple-pathogen specific dsRNA is disclosed.
US08507456B2 C5a binding nucleic acids
The present invention is related to a nucleic acid, preferably binding to C5a, selected from the group comprising type A nucleic acids, type B nucleic acids, type C nucleic acids, type D nucleic acids and nucleic acids having a nucleic acid sequence according to any of SEQ.ID.No. 73 to 79.
US08507451B1 Method for the treatment of type II diabetes
A method of treating Type II diabetes utilizing two off-the-shelf drugs.Intravenous injection of one or both drugs, individually and in combination, can prevent and treat diabetes, restore damaged islet cell functions and reduce or stop the use of oral hypoglycemic agents and insulin.
US08507449B2 Crystalline D-isoglutamyl-D-tryptophan and the mono ammonium salt of D-isoglutamyl-D-tryptophan
A process for making pure crystalline D-isoglutamyl-D-tryptophan is provided which includes the step of deprotecting essentially pure N-tert-butoxycarbonyl-D-isoglutamyl-D-tryptophan or its diester to yield essentially pure D-isoglutamyl-D-tryptophan. A process is also provided for the preparation of pure mono ammonium salt of D-isoglutamyl-D-tryptophan from essentially pure N-tert-butoxycarbonyl-D-isoglutamyl-D-tryptophan. D-isoglutamyl-D-tryptophan, ammonium salt (1:1) is a stable pharmaceutical solid.
US08507448B2 Human CD154-binding synthetic peptide and uses thereof
The invention refers to a synthetic peptide comprising an amino acid sequence of seven residues in length, preferably flanked by 2 cysteine residues at both ends, which is capable of specifically recognizing human CD154 and blocking CD40:CD154 interaction, thereby inhibiting the biological effects depending on such interaction. The peptide of the invention, which is preferably in a cyclic form, is suitable for use for diagnostic and therapeutic applications, especially for the diagnosis and therapy of tumor, inflammatory diseases and transplant rejection.
US08507445B2 Compositions and methods of use of targeting peptides for diagnosis and therapy of human cancer
The present invention concerns compositions comprising and methods of identification and use of targeting peptides selective for cancer tissue, particularly prostate or ovarian cancer tissue. The method may comprise identifying endogenous mimeotopes of such peptides, such as GRP78, IL-11Rα and hsp90. Antibodies against such targeting peptides or their mimeotopes may be used for detection, diagnosis and/or staging of prostate or ovarian cancer. In other embodiments, the compositions and methods concern a novel type of gene therapy vector, known as adeno-associated phage (AAP). AAP are of use for targeted delivery of therapeutic agents to particular tissues, organs or cell types, such as prostate or ovarian cancer. In still other embodiments, targeting peptides selective for low-grade lipomas may be used for detection, diagnosis and targeted delivery of therapeutic agents.
US08507444B2 ApoIII and the treatment and diagnosis of diabetes
The present invention provides methods of identifying candidate compounds for the treatment of type I diabetes comprising contacting pancreatic β cells with an amount of apolipoprotein CIII (“apoCIII”) effective to increase intracellular calcium concentration, in the presence of one or more test compounds, and identifying those test compounds that inhibit an apoCIII-induced increase in intracellular calcium concentration in the pancreatic β cells. The present invention also provides methods for treating patients with type I diabetes comprising administering to the patient an amount effective of an inhibitor of apoCIII to reduce apoCIII-induced increase in intracellular calcium concentration in pancreatic β cells.
US08507442B2 Methods of use for an antibody against human frizzled receptors 1, 2. 5, 7 or 8
Novel anti-cancer agents, including, but not limited to, antibodies, that bind to human frizzled receptors are provided. Novel epitopes within the human frizzled receptors which are suitable as targets for anti-cancer agents are also identified. Methods of using the agents or antibodies, such as methods of using the agents or antibodies to inhibit Wnt signaling and/or inhibit tumor growth are further provided.
US08507440B2 Protein kinase C peptides for use in withdrawal
A method for managing withdrawal from an addictive substance is described. The method involves administering one or more peptides having specific activity for the ε and/or γ isozyme of protein kinase C (PKC). The peptide(s) can be administered prior to, concurrent with, or subsequent to administration of the addictive substance. Also described is a kit having at least one container containing a peptide having isozyme-specific activity for εPKC or γPKC and instructions for use.
US08507438B2 Compositions and methods for the treatment of neurologic and psychiatric conditions
The invention provides pharmaceutical compositions and methods of use thereof for preventing or ameliorating disorders of the nervous system. More specifically, the invention provides pharmaceutical compositions, including phosphopeptides, that when administered disrupt TrkB-mediated activation of PLCγ1 phosphorylation. The invention further provides method of treatment comprising administering inhibitors of TrkB-mediated activation of PLCγ1 phosphorylation alone or in combination with other pharmaceutical compositions to prevent or ameliorate nervous system disorders such as epilepsy, stroke, anxiety, migraine, and pain.
US08507430B2 Methods for administering FGF18
FGF18 is known to stimulate the proliferation of chondrocytes, resulting in increased cartilage formation. When hyaluronic acid is administered in addition to FGF18, the effects on chondrocyte proliferation and production of matrix were found to be greater than administration of FGF18 or hyaluronic acid alone.
US08507429B2 Sugar chain added GLP-1 peptide
The present invention relates to an oligosaccharide chain added GLP-1 peptide that has higher stability in blood than that of GLP-1 and, preferably, exhibits higher activity of controlling blood-sugar levels than that of GLP-1. The present invention relates to an oligosaccharide chain added GLP-1 peptide having GLP-1 activity, wherein at least one amino acid is substituted with an oligosaccharide chain added amino acid, in: (a) GLP-1; (b) a peptide having the amino acid sequence of GLP-1 with deletion, substitution or addition of one or several amino acids; or (c) a GLP-1 analog.
US08507424B2 Process for producing oligomers
The present invention relates to a process for producing oligomers and a method for improving the low temperature properties of fatty alkyl esters by using these oligomers. The oligomers according to the present invention are used as pour point depressant and cloud point reducer to improve the pour point and cloud point of fatty alkyl esters such as isopropyl, butyl, ethyl, ethylhexyl esters particularly fatty acid methyl esters at low temperature.
US08507415B2 Lubricant oils and greases containing nanoparticle additives
Lubricant oil and grease composition containing an additive package comprising wear-resistant additives in the form of nanoparticles, wherein the additives are a carbonate selected from the group consisting of a carbonate of a Group 1a alkali metal and a carbonate of a Group 2a alkaline earth metal, a sulfate of a Group 1a alkali metal or a Group 2a alkaline earth metal, a phosphate of a Group 1a alkali metal or Group 2a alkaline earth metal, a carboxylate of a Group 1a alkali metal and a carbonate of a Group 2a alkaline earth metal, or a combination thereof.
US08507412B2 Methods for using non-volatile phosphorus hydrocarbon gelling agents
New fluids are disclosed for use in servicing subterranean formations containing oil and gas. In particular, an improved chemical gelling additive for hydrocarbon based fracturing fluids is disclosed having reduce, negligible or no volatile phosphorus at temperatures below about 250° C.
US08507411B2 Neoglycorandomization and digitoxin analogs
The present invention provides methods of producing libraries of compounds with enhanced desirable properties and diminished side effects as well as the compounds produced by the methods. In preferred embodiments, methods of the present invention use a universal chemical glycosylation method that employs reducing sugars and requires no protection or activation. In a preferred embodiment, the invention provides a library of neoglycoside digitoxin analogs that includes compounds with significantly enhanced cytotoxic potency toward human cancer cells and tumor-specificity, but are less potent Na+/K+-ATPase inhibitors in a human cell line than digitoxin.
US08507408B2 Synergistic combination of a glyphosate compound and one of DCOIT or OIT or BBIT
A synergistic antimicrobial composition containing a glyphosate compound and one of 4,5-dichloro-2-n-octyl-4-isothiazolin-3-one or 2-n-octly-4-isothiazolin-3-one or N-Butyl-1,2-benzisothiazolin-3-one is provided. Also provided is a method of inhibiting the growth of or controlling the growth of microorganisms in a building material by adding such a synergistic antimicrobial composition. Also provided is a coating composition containing such a synergistic antimicrobial composition, and a dry film made from such a coating composition.
US08507407B2 Multi-aperture carbon granule air purificant and production method
This invention provides a multi-aperture carbon granule air purificant and production method thereof, and belongs to the technical field of air purification. The air purificant is made from carbon powder, attapulgite, sepiolite, zeolite, cationic surfactant, pore-forming agent, and bamboo vinegar. The rational design that carbon powder (including plant carbon and activated carbon) of the air purificant mentioned above is treated with nano minerals, attapulgite, sepiolite, zeolite and so on, improves plant carbon adsorption capacity (over 5 folds) and activated carbon adsorption capacity (over 2 folds). Moreover it has additional bactericidal and antibacterial actions besides for the effects of cationic surfactant and bamboo vinegar. Compared with other adsorbents under current techniques, this air purificant still holds high adsorption capacity even at high temperature and low partical pressure of adsorbates, and maintains the function of plant carbon's releasing anion and far infrared at the meantime.
US08507406B2 Zn4(OH)2(1,2,4-BTC)2—a rod packing microporous metal-organic framework with open metal sites for selective separation and sensing of small molecules
Disclosed herein are rod-packing robust microporous metal-organic frameworks having the repeat unit Zn4(OH)2(1,2,4-BTC)2, useful for applications such as selective gas storage, selective gas sorption and/or separation, selective sensing of chemicals, and catalysis.
US08507400B2 Method of making a catalyst
Presented are one or more aspects and/or one or more embodiments of catalysts, methods of preparation of catalyst, methods of deoxygenation, and methods of fuel production.
US08507395B2 Dielectric ceramic composition and ceramic electronic device
A dielectric ceramic composition comprising a compound expressed by a formula of ABO3, where “A” is Ba alone, or Ba and at least one selected from Ca and Sr, and “B” is Ti alone, or Ti and Zr, and having a perovskite-type crystal structure, and an oxide of a rare-earth element including Sc and Y. The dielectric ceramic composition includes a dielectric particle having a core-shell structure which has a core and a shell, the shell being present around the core and including at least “R” element, and in the shell, a region showing a maximum content rate of “R” element is a boundary region between the core and the shell.
US08507394B2 Glass composition
There is provided a glass composition having a devitrification temperature of 1000° C. or below, a glass transformation temperature (Tg) of 535° C. or below and a specific gravity within a range from 3 to 4.The glass composition has a refractive index (nd) within a range from 1.60 to 1.75 and an Abbe number (νd) within a range from 50 to 60.
US08507392B2 LAS-type float glass
An LAS-type float glass, which is substantially free of As2O3 and/or Sb2O3 and precipitates a β-quartz solid solution or a β-spodumene solid solution as a main crystal by heat treatment, wherein, when C1 [mass %] represents the content of SnO2 at a glass surface, C0 [mass %] represents the content of SnO2 at a depth of 0.5 mm from the glass surface, and k [mass %/mm] represents an SnO2 concentration gradient defined by k=(C1-C0)/0.5, the LAS-type crystallized glass satisfies relationships of K≦2 and C0≦0.8 with respect to at least one surface thereof.
US08507391B2 Elastic articles, particularly drive belts, having a textile overlay and a bonding agent made from meltable plastic
An article has an elastic main element based on a vulcanizate having a wear-susceptible article surface. The article is primarily a drive belt (8) having a top layer (9) as the belt rear and a substructure (10) having a force transmission zone (13), wherein the force transmission zone and/or the top layer is/are supplied with a textile overlay (15), wherein the textile overlay is in turn additionally prepared with a plastic. The plastic is a bonding agent that is arranged between the main body and the textile overlay (15), wherein the plastic is supplied such that it melts during vulcanization and penetrates into the textile overlay while bonding, connected to a permanent adhesive bond between main body and textile overlay. A cotton fabric is used as the textile overlay (15), for example. The plastic is in the form of a film, for example, particularly in the form of a PE film. The primary purpose of use is the V-belt, ribbed V-belt (8) and the toothed belt.
US08507390B2 Methods and devices for forming nanostructure monolayers and devices including such monolayers
Methods for forming or patterning nanostructure arrays are provided. The methods involve formation of arrays on coatings comprising nanostructure association groups, formation of arrays in spin-on-dielectrics, solvent annealing after nanostructure deposition, patterning using resist, and/or use of devices that facilitate array formation. Related devices for forming nanostructure arrays are also provided, as are devices including nanostructure arrays (e.g., memory devices).
US08507379B2 Semiconductor device and manufacturing method thereof
A semiconductor device and a manufacturing method thereof are disclosed. The method comprises: providing a substrate with a first dielectric layer and a gate, wherein the gate is embedded in the first dielectric layer and an upper portion of the gate is an exposed first metal; and covering only the exposed first metal with a conductive material that is harder to be oxidized than the first metal by a selective deposition. An advantage of the present invention is that the metal of the upper surface of the gate is prevented from being oxidized by covering the metal gate with the conductive material that is relatively harder to be oxidized, thereby facilitating the formation of an effective electrical connection to the gate.
US08507372B2 Method for processing a substrate having a non-planar substrate surface
A technique for conformal processing of a substrate having a non-planar surface is disclosed. The technique includes several stages. In a first stage, some surfaces of the substrate are effectively processed. During a second stage, these surfaces are treated to limit or eliminate further processing of these surfaces. During a third stage, other surfaces of the substrate are processed. In some applications, the surfaces that are perpendicular, or substantially perpendicular to the flow of particles are processed in the first and second stages, while other surfaces are processed in the third stage. In some embodiments, the second stage includes the deposition of a film on the substrate.
US08507367B2 Separation of semiconductor devices
A method of fabricating semiconductor devices is disclosed. The method comprises providing a substrate with a plurality of epitaxial layers mounted on the substrate and separating the substrate from the plurality of epitaxial layers while the plurality of epitaxial layers is intact. This preserves the electrical, optical, and mechanical properties of the plurality of epitaxial layers.
US08507366B2 Rapid thermal processing system and sulfidation method thereof
A rapid thermal processing system includes a rapid thermal processing furnace, a back electrode substrate, and a cover. The rapid thermal processing furnace includes a reaction chamber and a heating device. The heating device is capable of generating heat energy. The back electrode substrate is adapted to dispose in the reaction chamber and has a precursor layer and a selenium layer formed on the precursor layer. The cover is disposed at a position corresponding to the selenium layer on the back electrode substrate and has a sulfur in solid form formed thereon, so as to make the sulfur in solid form opposite to the selenium layer. After the sulfur in solid form absorbs the heat energy generated by the heating device, the sulfur in solid form reacts with the selenium layer and the precursor layer to form a photoelectric transducing layer.
US08507357B2 Method for lift-off of light-emitting diode substrate
The present invention discloses a method for lift-off of an LED substrate. By eroding the sidewall of a GaN epitaxial layer, cavity structures are formed, which may act in cooperation with a non-fully filled patterned sapphire substrate from epitaxial growth to cause the GaN epitaxial layer to separate from the sapphire substrate. The method according to an embodiment of the present invention can effectively reduce the dislocation density in the growth of a GaN-based epitaxial layer; improve lattice quality, and realize rapid lift-off of an LED substrate, and has the advantages including low cost, no internal damage to the GaN film, elevated performance of the photoelectric device and improved luminous efficiency.
US08507356B2 Formation of wells utilizing masks in manufacturing semiconductor device
Semiconductor device manufacturing method includes forming a first mask, having a first opening to implant ion into semiconductor substrate and being used to form first layer well, on semiconductor substrate; forming first-layer well having first and second regions by implanting first ion into semiconductor substrate using first mask; forming second mask, having second opening to implant ion into semiconductor substrate and being used to form second layer well, on semiconductor substrate; and forming second-layer well below first layer well by implanting second ion into semiconductor substrate using second mask. First region is formed closer to an edge of first-layer well than second region. Upon implanting first ion, first ion deflected by first inner wall of first mask is supplied to first region. Upon implanting second ion, second ion deflected by second inner wall of second mask is supplied to second region.
US08507354B2 On-chip capacitors in combination with CMOS devices on extremely thin semiconductor on insulator (ETSOI) substrates
A device including a semiconductor on insulator (SOI) substrate including a semiconductor device region and a capacitor device region. A semiconductor device present in the semiconductor device region. The semiconductor device including a gate structure present on a semiconductor on insulator (SOI) layer of the SOI substrate, extension source and drain regions present in the SOI layer on opposing sides of the gate structure, and raised source and drain regions composed of a first portion of an epitaxial semiconductor material on the SOI layer. A capacitor is present in the capacitor device region, said capacitor including a first electrode comprised of a second portion of the epitaxial semiconductor material that has a same composition and crystal structure as the first portion of the epitaxial semiconductor material, a node dielectric layer present on the second portion of the epitaxial semiconductor material, and a second electrode comprised of a conductive material.
US08507352B2 Method of manufacturing semiconductor device including insulated gate bipolar transistor and diode
In a method of manufacturing a semiconductor device, a semiconductor substrate of a first conductivity type having first and second surfaces is prepared. Second conductivity type impurities for forming a collector layer are implanted to the second surface using a mask that has an opening at a portion where the collector layer will be formed. An oxide layer is formed by enhanced-oxidizing the collector layer. First conductivity type impurities for forming a first conductivity type layer are implanted to the second surface using the oxide layer as a mask. A support base is attached to the second surface and a thickness of the semiconductor substrate is reduced from the first surface. An element part including a base region, an emitter region, a plurality of trenches, a gate insulating layer, a gate electrode, and a first electrode is formed on the first surface of the semiconductor substrate.
US08507349B2 Semiconductor device employing fin-type gate and method for manufacturing the same
A semiconductor device comprises an active region having an upper portion and a sidewall portion which are protruded from the top surface of a device isolation region, and a silicide film disposed in the upper portion and the sidewall portion of the active region, thereby effectively reducing resistance in a source/drain region of the semiconductor device. As a result, the entire resistance of the semiconductor device comprising a fin-type gate can be reduced to improve characteristics of the semiconductor device.
US08507345B2 Semiconductor device and manufacturing method thereof
An aspect of the present invention provides a semiconductor device that includes a first conductivity type semiconductor body, a source region in contact with the semiconductor body, whose bandgap is different from that of the semiconductor body, and which formed heterojunction with the semiconductor body, a gate insulating film in contact with a portion of junction between the source region and the semiconductor body, a gate electrode in contact with the gate insulating film, a source electrode, a low resistance region in contact with the source electrode and the source region, and connected ohmically with the source electrode, and a drain electrode connected ohmically with the semiconductor body.
US08507344B2 Semiconductor device having a buried gate and method for manufacturing the same
A semiconductor device and a method for manufacturing the same are disclosed. The method for forming the semiconductor device includes forming one or more buried gates in a semiconductor substrate, forming a landing plug between the buried gates, forming a bit line region exposing the landing plug over the semiconductor substrate, forming a glue layer in the bit line region, forming a bit line material in the bit line region, and removing the glue layer formed at inner sidewalls of the bit line region, and burying an insulation material in a part where the glue layer is removed. A titanium nitride (TiN) film formed at sidewalls of the damascene bit line is removed, so that resistance of the bit line is maintained and parasitic capacitance of the bit line is reduced, resulting in the improvement of device characteristics.
US08507339B2 BiCMOS device
In a BiCMOS device, a device isolation film separating the bipolar transistor region from the MOS region is taller than the substrate at least where it contacts the bipolar transistor region, and is preferably taller than the same layer where it contacts the MOS transistor region. This makes it possible to maintain the processing accuracy of a MOS transistor while stabilizing the diode current characteristics of the bipolar transistor.
US08507337B2 Method for doping semiconductor structures and the semiconductor device thereof
A method for introducing species into a strained semiconductor layer comprising: providing a substrate comprising a first region comprising an exposed strained semiconductor layer, loading the substrate in a reaction chamber, then forming a conformal first species containing-layer by vapor phase deposition (VPD) at least on the exposed strained semiconductor layer, and thereafter performing a thermal treatment, thereby diffusing at least part of the first species from the first species-containing layer into the strained semiconductor layer and activating at least part of the diffused first species in the strained semiconductor layer.
US08507336B2 Method for forming metal gate and MOS transistor
The invention provides a method for forming a metal gate and a method for forming a MOS transistor. The method for forming a metal gate includes: providing a substrate; forming a sacrificial oxide layer and a polysilicon gate on the substrate; forming a silicon oxide layer on sidewalls of the sacrificial oxide layer and the polysilicon gate; forming a stop layer that covers the substrate; removing a part of the stop layer in the spacers; forming a second interlayer dielectric layer that covers the first interlayer dielectric layer, the spacers and the polysilicon gate; polishing the second interlayer dielectric layer to expose the spacers and the polysilicon gate; removing the polysilicon gate to form a trench; removing the sacrificial oxide layer in the trench; and forming a metal gate in the trench. The invention prevents from recesses and therefore metal bridge and metal residuals in the recesses.
US08507335B2 Semiconductor devices with non-punch-through semiconductor channels having enhanced conduction and methods of making
Semiconductor devices are described wherein current flow in the device is confined between the rectifying junctions (e.g., p-n junctions or metal-semiconductor junctions). The device provides non-punch-through behavior and enhanced current conduction capability. The devices can be power semiconductor devices as such as Junction Field-Effect Transistors (VJFETs), Static Induction Transistors (SITs), Junction Field Effect Thyristors, or JFET current limiters. The devices can be made in wide bandgap semiconductors such as silicon carbide (SiC). According to some embodiments, the device can be a normally-off SiC vertical junction field effect transistor. Methods of making the devices and circuits comprising the devices are also described.
US08507331B2 Method of adjusting gap between bumps in pixel region and method of manufacturing display device using the method
A method of manufacturing a display device includes forming a buffer layer on a top surface of a substrate, forming an amorphous silicon layer on a top surface of the buffer layer, and forming a polysilicon layer by irradiating the amorphous silicon layer with a laser beam. A plurality of first protrusions are formed on the top surface of the polysilicon layer, and a plurality of second protrusions are formed on a surface of the buffer layer by transferring the shape of the polysilicon layer to the buffer layer. A gate insulator on the buffer layer is then formed in the shape of bumps of the second protrusions.
US08507330B2 Thin film transistor
A method is proposed for producing a thin-film transistor (TFT), the method comprising forming a substrate, applying a ZnO-based precursor solution onto the substrate to form a ZnO-based channel layer, annealing the channel layer, forming a source electrode and a drain electrode on the channel layer, forming a dielectric layer on the channel layer and forming a gate electrode on the dielectric layer.
US08507329B2 Compound semiconductor device and method of manufacturing the same
A compound semiconductor device is provided with a substrate, an AlN layer formed over the substrate, an AlGaN layer formed over the AlN layer and larger in electron affinity than the AlN layer, another AlGaN layer formed over the AlGaN layer and smaller in electron affinity than the AlGaN layer. Furthermore, there are provided an i-GaN layer formed over the latter AlGaN layer, and an i-AlGaN layer and an n-AlGaN layer formed over the i-GaN layer.
US08507325B2 Co-axial restraint for connectors within flip-chip packages
An assembly can include a microelectronic element such as, for example, a semiconductor element having circuits and semiconductor devices fabricated therein, and a plurality of electrical connectors, e.g., solder balls attached to contacts of the microelectronic element. The connectors can be surrounded by first, inner regions 200 of compressible dielectric material and second, outer regions of dielectric material. In one embodiment, an underfill can contact a face of the microelectronic element between respective connectors or second regions. The second regions can provide restraining force, such that during volume expansion of the connectors, the first regions can compress against the restraining force of the second regions.
US08507320B2 Electronic device including a carrier and a semiconductor chip attached to the carrier and manufacturing thereof
One aspect is a method including providing a carrier having a first conducting layer, a first insulating layer over the first conducting layer, and at least one through-connection from a first face of the first insulating layer to a second face of the first insulating layer; attaching at least two semiconductor chips to the carrier; applying a second insulating layer over the carrier; opening the second insulating layer until the carrier is exposed; depositing a metal layer over the opened second insulating layer; and separating the at least two semiconductor chips after depositing the metal layer.
US08507318B2 Method for manufacturing microelectronic devices
Microelectronic devices, stacked microelectronic devices, and methods for manufacturing microelectronic devices are described herein. In one embodiment, a set of stacked microelectronic devices includes (a) a first microelectronic die having a first side and a second side opposite the first side, (b) a first substrate attached to the first side of the first microelectronic die and electrically coupled to the first microelectronic die, (c) a second substrate attached to the second side of the first microelectronic die, (d) a plurality of electrical couplers attached to the second substrate, (e) a third substrate coupled to the electrical couplers, and (f) a second microelectronic die attached to the third substrate. The electrical couplers are positioned such that at least some of the electrical couplers are inboard the first microelectronic die.
US08507313B2 Method of manufacturing photoelectric conversion device
A fragile layer is formed in a region at a depth of less than 1000 nm from one surface of a single crystal semiconductor substrate, and a first impurity semiconductor layer and a first electrode are formed at the one surface side. After bonding the first electrode and a supporting substrate, the single crystal semiconductor substrate is separated using the fragile layer or the vicinity as a separation plane, thereby forming a first single crystal semiconductor layer over the supporting substrate. An amorphous semiconductor layer is formed on the first single crystal semiconductor layer, and a second single crystal semiconductor layer is formed by heat treatment for solid phase growth of the amorphous semiconductor layer. A second impurity semiconductor layer having a conductivity type opposite to that of the first impurity semiconductor layer and a second electrode are formed over the second single crystal semiconductor layer.
US08507307B2 Group IIB/VA semiconductors suitable for use in photovoltaic devices
The present invention relates to devices, particularly photovoltaic devices, incorporating Group IIB/VA semiconductors such phosphides, arsenides, and/or antimonides of one or more of Zn and/or Cd. In particular, the present invention relates to methodologies, resultant products, and precursors thereof in which electronic performance of the semiconductor material is improved by causing the Group IIB/VA semiconductor material to react with at least one metal-containing species (hereinafter co-reactive species) that is sufficiently co-reactive with at least one Group VA species incorporated into the Group IIB/VA semiconductor as a lattice substituent (recognizing that the same and/or another Group VA species also optionally may be incorporated into the Group IIB/VA semiconductor in other ways, e.g., as a dopant or the like).
US08507303B2 Thin film transistor array panel and method for manufacturing the same
The present invention provides a thin film transistor array panel including an insulating substrate, a gate line formed on the insulating substrate, a gate insulating layer formed on the gate line, a drain electrode and a data line having a source electrode formed on the gate insulating layer wherein the drain electrode faces the source electrode with a gap therebetween, and a pixel electrode connected to the drain electrode. At least one of the gate line, the data line, and the drain electrode includes a first conductive layer made of a conductive oxide and a second conductive layer of Ag that is deposited adjacent to the first conductive layer.
US08507299B2 Light emitting diode package and manufacturing method thereof
The present invention relates to a light emitting diode package and a manufacturing method thereof.The light emitting diode package includes a substrate, an LED chip mounted on an upper part of a substrate, a molding material coated at the upper part of the substrate including an external surface of the LED chip, and an encapsulant coated at a lower part of the substrate and can improve luminous efficiency, minimize a package failure, and reduce a manufacture cost by facilitating the manufacturing process.
US08507298B2 Patterned implant of a dielectric layer
At least part of a dielectric layer is implanted to form implanted regions. The implanted regions affect the etch rate of the dielectric layer during the formation of the openings through the dielectric layer. Metal contacts may be formed within these openings. The dielectric layer, which may be SiO2 or other materials, may be part of a solar cell or other device.
US08507296B2 Substrate processing method and film forming method
A substrate processing method in a processing chamber, has: accommodating a substrate into a processing chamber; and processing the substrate in the processing chamber on the basis of a correlation of a preset temperature of a heating device, a flow rate of fluid supplied by a cooling device and a temperature deviation between the center side of the substrate accommodated in the processing chamber and the outer peripheral side of the substrate while the substrate accommodated in the processing chamber is optically heated from an outer periphery side of the substrate at a corrected preset temperature by the heating device and the fluid is supplied to the outside of the processing chamber at the flow rate based on the correlation concerned to cool the outer peripheral side of the substrate by the cooling device.
US08507295B2 Methods of quantification for lateral flow devices
The invention concerns methods of quantification of an analyte, A, in a test sample by means of a single immunochromatographic device, such as a lateral flow device (LFD). One method comprises the steps of: a) mixing a determined amount of said test sample with a determined amount of a quantification agent, QA1, said QA1 being capable of binding specifically and simultaneously both to an immobilized binding partner and to A, thus obtaining a mixture wherein the amount of A in said test sample is reflected by the ratio of the concentration of A-QA1 complex formed to the concentration of free QA1 in said mixture; b) applying a determined volume of said mixture to said device equipped with a test band in which said binding partner of the QA1 is immobilized, so that A-QA1 complex and free QA1 are immobilized at said test band in a ratio that relates to their concentration ratio in the mixture applied, said volume of mixture being determined to provide a total amount of A-QA1 complex and free QA1 capable of sufficiently saturating the immobilized binding partner in said test band; c) measuring the amount of either said A-QA1 complex or said free QA1 immobilized at the test band by means of an appropriately chosen detection procedure; d) comparing the result obtained from the test sample with the results obtained from calibration samples containing known or allocated amounts of A and thus determining the amount of A in said test sample. By including the two procedural stages a) and b) this greatly diminish or eliminate the sources of run-to-run variation.
US08507293B2 Medium switching systems and methods using acoustic radiation pressure
A method to produce an assay is provided. The method includes introducing into a channel having a peripheral wall a first fluid having a first acoustic contrast, and introducing into a substantially peripheral portion of the channel a second fluid having a second acoustic contrast that is different from the first acoustic contrast, the substantially peripheral portion reaching from within the channel to the peripheral wall of the channel, wherein the second fluid is a biological fluid. The method further includes applying acoustic radiation pressure to the channel, and acoustically reorienting the second fluid based upon the difference between the first acoustic contrast and the second acoustic contrast such that the acoustically reoriented second fluid is translated from the substantially peripheral portion of the channel to a substantially internal portion of the channel that does not reach the peripheral wall of the channel.
US08507291B1 Detergent removal from protein samples prior to mass spectrometry analysis
A method to remove detergents from a biological protein sample that is to be analyzed by mass spectroscopy (MS). The method uses a high performance cyclodextrin polymer resin to remove detergents, which interfere with MS analysis, from a sample containing proteins, peptides, amino acids, etc.
US08507288B2 Nitrogen dioxide sensing apparatus and method using carbon nanomaterials as an ozone removal material
The invention relates to the use of carbon nanomaterials as a filtration material pervious to nitrogen dioxide and impervious to ozone. The invention also relates to the use of carbon nanomaterials having a specific surface, measured by the BET method, of 15 to 40 m2/g inclusive and a form factor, equal to the ratio (highest dimension/lowest dimension) of the nanomaterial, of 5 to 250 inclusive, as material for filtering a gas mixture containing nitrogen dioxide and ozone, being pervious to the nitrogen dioxide and impervious to the ozone. The invention can be used in the field of air pollution.
US08507286B1 Method of analyzing oxidation state of methionine in protein sample
Disclosed is a method of analyzing an oxidation state of a methionine residue in a protein sample, which comprises the steps of: inducing a reaction between a protein sample having a methionine residue with an oxidation state to be analyzed, and hydrogen peroxide H218O2 having oxygen atoms labeled by the isotope 18O, to obtain a modified protein sample in which the oxidation state of the methionine residue is stabilized; and subjecting the modified protein sample to a measurement to quantify an oxidation degree of the methionine residue. Preferably, the measurement is a mass spectrometric (MS) measurement using a mass spectrometer. The method can analyze an oxidation state of a methionine residue in a protein sample, in a simple manner, while accurately reflecting an in vivo oxidation state of the methionine residue.
US08507285B2 Methods and devices for identifying biopolymers using mass spectroscopy
A method of identifying a biopolymer in a sample that includes one or more biopolymers. The biopolymers may be polypeptides, polynucleotides, or polysaccharides. The method makes use of mass spectral datasets. A first dataset includes measured masses of the one or more biopolymers that are in the sample. A second dataset includes measured masses of a collection of fragments of the one or more biopolymers. The method selects a mass from the first dataset and then matches masses from the second dataset with the selected mass. The matched masses represent fragments of the biopolymer with the selected mass. Once the masses in the second dataset have been matched they are compared to determine a monomer sequence for the biopolymer with the selected mass. The method may be repeated with additional masses in the first dataset.
US08507277B2 Nonviral vectors for delivering polynucleotides
Methods and compositions for delivering polynucleotides are provided. One embodiment provides a non-viral vector comprising a recombinant polynucleotide-binding protein comprising a protein transduction domain operably linked to a targeting signal. Methods for modifying the genome of non-nuclear organelles are also provided.
US08507276B2 Tissue culture media used as a component of cosmetics
A cosmetic or dermatological preparation which comprises one or more tissue culture media, in particular one or more skin cell culture media.
US08507275B2 Method of inducing differentiation of embryonic stem cells into hemangioblast
The present invention relates to a composition for inducing embryonic stem cell differentiation comprising a MEK/ERK (mitogen-activated protein kinase kinase/extracellular regulated kinase) signal transduction inhibitor and BMP (bone morphogenetic protein), and a method for inducing differentiation of embryonic stem cells into mesodermal cells using the same. Further, the mesodermal cells obtained by the above method are able to differentiate into various mesenchymal tissue cells. In particular, the present invention relates to a method for inducing differentiation into hemangioblast by culturing the mesodermal cells obtained by the above method in the presence of VEGF (vascular endothelial cell growth factor) and bFGF (basic fibroblast growth factor). The differentiated hemangioblasts can be further differentiated into vascular endothelial cells, vascular smooth muscle cells, and hematopoietic stem cells under various culture conditions.
US08507273B2 Gene encoding a multidrug resistance human P-glycoprotein homologue on chromosome 7p15-21 and uses thereof
The invention relates to an MDR family P-glycoprotein located on human chromosome 7p15-21, polynucleotide sequences encoding this P-glycoprotein and fragments thereof. This gene is utilized in methods for assessing cancer cell susceptibility to therapies directed against multidrug resistance, and for the design of diagnostic and therapeutic methods relating to cancer multidrug resistance. The invention also relates to methods for determining whether a test compound may inhibit multidrug resistance.
US08507271B2 Cells useful for immuno-based botulinum toxin serotype A activity assays
The present specification discloses clonal cell lines susceptible to BoNT/A intoxication, methods of producing such clonal cell lines, and methods of detecting Botulinum toxin serotype A activity using such clonal cell lines.
US08507267B2 AAV4 vector and uses thereof
The present invention provides an adeno-associated virus 4 (AAV4) virus and vectors and particles derived therefrom. In addition, the present invention provides methods of delivering a nucleic acid to a cell using the AAV4 vectors and particles.
US08507266B2 Apparatus and method for tissue engineering
A bioreactor system includes a housing and a hydrostatic loading module. The housing includes a chamber with an inlet port and an outlet port. The inlet and outlet ports allowing the chamber to be continuously perfused with a culture medium while chamber is hydrostatically loaded.
US08507264B2 Photobioreactor systems and methods for treating CO2-enriched gas and producing biomass
Certain embodiments and aspects of the invention relate to a photobioreactor including covered photobioreactor units through which a liquid medium stream and a gas stream flow. The liquid medium comprises at least one species of phototrophic organism therein. Certain methods of using the photobioreactor system as part of fuel generation system and/or a gas-treatment process or system at least partially remove certain undesirable pollutants from a gas stream. In certain embodiments, a portion of the liquid medium is diverted from a photobioreactor unit and reintroduced upstream of the diversion position. In certain embodiments, the disclosed photobioreactor system, methods of using such systems, and/or gas treatment apparatus and methods provided herein can be used as part of an integrated combustion method and system, wherein photosynthetic organisms used within the photobioreactor are harvested from the photobioreactor, processed, and used as a fuel source for a combustion system like an electric power plant.
US08507263B2 Rotating bioreactor
Articles and methods for growing tissues and organs using bioreactors, including rotating bioreactors, are provided. In some embodiments, a bioreactor is configured to provide a first and second chamber, such as an inner and an outer chamber, respectively. The chambers may be co-axially arranged with respect to each other. A wall of the bioreactor defining the two chambers may be formed at least in part from a scaffold derived from a length of a hollow or tubular tissue or organ. Such a bioreactor can be used to form biocompatible structures for tissue engineering and organ replacement, such as cellular tissues, organ-like structures, and/or complete organs, within the bioreactor.
US08507253B2 Photobioreactor cell culture systems, methods for preconditioning photosynthetic organisms, and cultures of photosynthetic organisms produced thereby
Certain embodiments of the invention involve methods and systems for preselecting, adapting, and preconditioning one or more species of photosynthetic organisms, such as algae, to specific environmental and/or operating conditions to which the photosynthetic organisms will subsequently be exposed during utilization in a photobioreactor apparatus of a gas treatment system. Also disclosed are new algal strains and cultures that can be produced by practicing the preselection, adaption, and preconditioning methods.
US08507251B2 Medium and method for culturing Mycobacterium avium subspecies paratuberculosis
The present invention provides a growth medium and kit containing a nicotine analog and use of the same in a method for enhancing the growth of Mycobacterium avium subspecies paratuberculosis (MAP).
US08507242B2 Thermophilic and thermoacidophilic biopolymer-degrading genes and enzymes from Alicyclobacillus acidocaldarius and related organisms, methods
Isolated and/or purified polypeptides and nucleic acid sequences encoding polypeptides from Alicyclobacillus acidocaldarius are provided. Further provided are methods of at least partially degrading, cleaving, or removing polysaccharides, lignocellulose, cellulose, hemicellulose, lignin, starch, chitin, polyhydroxybutyrate, heteroxylans, glycosides, xylan-, glucan-, galactan-, or mannan-decorating groups using isolated and/or purified polypeptides and nucleic acid sequences encoding polypeptides from Alicyclobacillus acidocaldarius.
US08507240B2 Hafnia phytase variants
The present invention relates to phytases having at least 76% identity to a phytase derived from Hafnia alvei and comprises at least one modification in the amino acid sequence thereof. These phytase variants have modified, preferably improved, properties, such as, reduced protease sensibility, preferably they exhibit improved properties in respect of thermal performance, such as heat-stability (temperature stability, thermostability), steam stability, pelleting stability and/or temperature profile; and/or protease stability, in particular pepsin stability, pH profile, specific activity, substrate specificity, performance in animal feed (such as an improved release and/or degradation of phytate), susceptibility to glycation, and/or glycosylation pattern. The invention also relates to DNA encoding these phytases, methods of their production, as well as the use thereof, e.g., in animal feed and animal feed additives.
US08507237B2 Device and method for concentrating and detecting pathogenic microbes from blood products and/or their derivatives
The invention concerns a device and a method for concentrating pathogenic germs potentiaily present in blood products or derivatives and for detecting said germs comprising the following steps: (a) subjecting a sample of said blood product to a blood cell aggregating treatment, (b) eliminating the aggregates formed at step (a) by passing the treated sample over a first filter allowing through the contaminating germs but not the cell aggregates, (c) selectively lyzing the residual cells of the filtrate obtained at step (b), (d) recuperating the contaminating germs by passing the lysate of step (c) over a second filter to detect the contaminating germs possibly trapped.
US08507236B2 Systems and methods for controlling objects
Systems and methods for controlling an object are disclosed. In one embodiment, a system and method pertain to irradiating the object with polarized electromagnetic radiation for a duration of time sufficient to effect a physical change with the object.
US08507232B2 Methods for fermentation of xylose and hexose sugars
Methods and systems for the isomerization and fermentation of xylose and hexose sugars using an immobilized enzyme system capable of sustaining two different pH microenvironments in a single vessel are disclosed. Bilayer particles are dispersed in a mixture comprising an ionic borate source and xylose. The bilayer particles have an inner of a xylose isomerase having a pH of 6 or above, and an outer region having a second enzymatic activity at an acidic pH.
US08507231B2 High throughput screening platform for high ethanol production
Provided herein are high throughput methods for converting starch-containing plant material to ethanol, wherein the conversion process is performed at a small scale. This high-throughput screening platform permits the evaluation of the ethanol obtained from starch-containing plant material in a rapid and efficient manner. The methods include obtaining a plurality of samples of starch-containing plant material and drying the samples to achieve a desired moisture level. The dried samples are liquefied under conditions sufficient to hydrolyze the starch-containing plant material to soluble dextrinized substrates. The liquefied samples are fermented in small volume headspace vials for a period of less than about 96 hours, and fermentation is terminated by pasteurization. Ethanol production is evaluated using headspace gas chromatography.
US08507229B2 Electrochemical method for producing a biodiesel mixture comprising fatty acid alkyl esters and glycerol
The present invention relates to an integrated method and system for the simultaneous production of biodiesel from free fatty acids (via esterification) and from triglycerides (via transesterification) within the same reaction chamber. More specifically, one preferred embodiment of the invention relates to a method and system for the production of biodiesel using an electrodeionization stack, wherein an ion exchange resin matrix acts as a heterogeneous catalyst for simultaneous esterification and transesterification reactions between a feedstock and a lower alcohol to produce biodiesel, wherein the feedstock contains significant levels of free fatty acid. In addition, because of the use of a heterogeneous catalyst, the glycerol and biodiesel have much lower salt concentrations than raw biodiesel produced by conventional transesterification processes. The present invention makes it much easier to purify glycerol and biodiesel.
US08507227B2 Method of producing sialylated oligosaccharides
The present invention relates to a method for the large scale in vivo synthesis of sialylated oligosaccharides, culturing a microorganism in a culture medium, optionally comprising an exogenous precursor such as lactose, wherein said microorganism comprises heterologous genes encoding a CMP-Neu5Ac synthetase, a sialic acid synthase, a GlcNAc-6-phosphate 2 epimerase and a sialyltransferase, and wherein the endogenous genes coding for sialic acid aldolase (NanA) and for ManNac kinase (NanK) have been deleted or inactivated. The invention also relates to these micoorganisms which are capable of producing internally activated sialic acid.
US08507225B2 Oligonucleotides for genotyping thymidylate synthase gene
Oligonucleotides for genotyping the thymidylate synthase gene are provided. The number of tandem repeats in the promoter region of the thymidylate synthase gene can be identified based on the hybridization of an oligonucleotide of the invention to the genomic DNA of a subject. Therefore, the genotype of the thymidylate synthase gene can be identified based on the number of tandem repeats. The genotype relates to the responsiveness of a subject towards an antitumor agent.
US08507224B2 Vectors and yeast strains for protein production: Ca2+ ATPase overexpression
Lower eukaryote host cells in which an endogenous or heterologous Ca2+ ATPase is overexpressed are described. Also described are lower eukaryote host cells in which a calreticulin and/or ERp57 protein are overexpressed. These host cells are useful for producing recombinant glycoproteins that have reduced O-glycosylation.
US08507223B2 Method for quantitative determination of glycated protein and kit for quantitative determination of the same
The present invention relates to a method for quantitative determination of an α-glycated peptide in a sample, comprising causing protease to act on a whole blood and/or blood cell sample, causing an elimination reagent containing one or a plurality of types of ketoamine oxidase to act on the resultant, eliminating an α-glycated amino acid, an ε-glycated amino acid, an ε-glycated peptide, or a combination thereof, and then determining the α-glycated peptide in the sample using oxidase that acts on the α-glycated peptide. The present invention also relates to an elimination reagent and a kit to be used for such method. According to the present invention, measurement errors in quantitative determination of a glycated protein such as glycated hemoglobin can be reduced, and thus a precise measured value can be obtained.
US08507222B2 Multimeric IL-15 soluble fusion molecules and methods of making and using same
The invention provides soluble fusion protein complexes having at least two soluble fusion proteins. The first fusion protein is a biologically active polypeptide covalently linked to an interleukin-15 (IL-15) polypeptide or a functional fragment thereof. The second fusion protein is a second biologically active polypeptide covalently linked to a soluble interleukin-15 receptor alpha (IL-15Rα) polypeptide or a functional fragment thereof. In the complexes of the invention, one or both of the first and second fusion proteins further includes an immunoglobulin Fc domain or a functional fragment thereof; and the first fusion protein binds to the soluble IL-15Rα domain of the second fusion protein to form a soluble fusion protein complex. The invention further provides methods for making and using the complexes of the invention.
US08507215B2 Diagnostics for membranous nephropathy
The invention provides immunoassays for detecting serum auto-antibodies reactive against a phospholipase A2 receptor (PLA2R) and uses thereof for diagnosis and prognosis evaluation of idiopathic membranous nephropathy (MN).
US08507211B2 Tuberculosis diagnostic test
A method of diagnosing in a host infection by or exposure to a mycobacterium which expresses ESAT-6 comprising (i) contacting a population of T cells from the host with one or more peptides or analogues selected from the peptides represented by SEQ ID NO:1 to 11 and analogues thereof which can bind a T cell receptor which recognises any of the said peptides, and (ii) determining whether the T cells of said T cell population recognise the peptide(s) and/or analogue(s). The method may performed in vivo. Peptides and a kit which enable the method to be carried out are provided.
US08507209B2 Biomarkers
The invention provides binding agents and assays for ghrelin signal peptide. The agents and assays are useful in methods for predicting, diagnosing, assessing or monitoring acute cardiac disorders, glucose handling disorders and diabetes in a subject. Also provided are nucleotides, polypeptides, and kits useful in the methods of the invention.
US08507202B2 Methods for diagnosing pancreatic cancer using MicroRNAs
The present invention provides novel methods and compositions for the diagnosis and treatment of solid cancers. The invention also provides methods of identifying inhibitors of tumorigenesis.
US08507199B2 Multi-color time resolved fluorophores based on macrocyclic lanthanide complexes
The present invention provides a novel class of macrocyclic compounds as well as complexes formed between a metal (e.g., lanthanide) ion and the compounds of the invention. Preferred complexes exhibit high stability as well as high quantum yields of lanthanide ion luminescence in aqueous media without the need for secondary activating agents. Preferred compounds incorporate hydroxy-isophthalamide moieties within their macrocyclic structure and are characterized by surprisingly low, non-specific binding to a variety of polypeptides such as antibodies and proteins as well as high kinetic stability. These characteristics distinguish them from known, open-structured ligands.
US08507198B2 Compositions and methods of selective nucleic acid isolation
The invention relates to methods for isolating and/or identifying nucleic acids. The invention also provides kits for isolating and/or identifying nucleic acids.
US08507196B1 Nucleic acid probe of human immunodeficiency virus type 1 (HIV-1), and a method and kit employing this probe for detecting the presence of nucleic acid of HIV-1
This invention is in the field of lymphadenopathy virus. This invention relates to a diagnostic means and method to detect the presence of DNA, RNA, or antibodies of the lymphadenopathy retrovirus associated with the acquired immune deficiency syndrome or of the lymphadenopathy syndrome by the use of DNA fragments or the peptides encoded by said DNA fragments. The invention further relates to the DNA fragments, vectors comprising them, and the proteins expressed.
US08507187B2 Multi-exposure lithography employing a single anti-reflective coating layer
A first photoresist is applied over an optically dense layer and lithographically patterned to form an array of first photoresist portions having a pitch near twice a minimum feature size. The pattern in the first photoresist portions, or a first pattern, is transferred into the ARC layer and partly into the optically dense layer. A second photoresist is applied and patterned into another array having a pitch near twice the minimum feature size and interlaced with the first pattern. The pattern in the second photoresist, or a second pattern, is transferred through the ARC portions and partly into the optically dense layer. The ARC portions are patterned with a composite pattern including the first pattern and the second pattern. The composite pattern is transferred through the optically dense layer and into the underlayer to form a sublithographic pattern in the underlayer.
US08507180B2 Chemically amplified positive-type photoresist composition for thick film, chemically amplified dry film for thick film, and method for production of thick film resist pattern
Disclosed are a chemically amplified positive-type photoresist composition for a thick film, a chemically amplified dry film for a thick film, and a method for producing a thick film resist pattern, all of which are capable of obtaining a satisfactory resist pattern with high sensitivity even on a substrate having a portion formed of copper on an upper surface thereof. The chemically amplified positive-type photoresist composition for a thick film comprises component (A) which includes at least one compound capable of producing an acid upon irradiation with an actinic ray or radiation, and component (B) which includes at least one resin whose alkali solubility increases by the action of an acid, in which the component (A) includes an onium fluorinated alkyl fluorophosphate having a specific structure.
US08507179B2 Switchable antireflective coatings
An antireflective coating compositions comprising (I) a silsesquioxane resin (II) a compound selected from photo-acid generators and thermal acid generators; and (III) a solvent wherein in the silsesquioxane resin contains a carboxylic acid forming group or a sulfuric acid forming group.
US08507178B2 Polychromic substances and their use
The invention relates to use of a diacetylene compound as a color former wherein the diacetylene compound has one of general formulae (I) to (V). The invention also includes methods of imparting color to a material including a compound as defined above, which comprises subjecting the material to irradiation.
US08507175B2 Patterning process and resist composition
The process forms a pattern by applying a resist composition onto a substrate to form a resist film, baking, exposure, post-exposure baking, and development. The resist composition comprises a polymer comprising recurring units having an acid labile group and substantially insoluble in alkaline developer, a PAG, a PBG capable of generating an amino group, a quencher for neutralizing the acid from PAG for inactivation, and an organic solvent. A total amount of amino groups from the quencher and PBG is greater than an amount of acid from PAG. An unexposed region and an over-exposed region are not dissolved in developer whereas only an intermediate exposure dose region is dissolved in developer. Resolution is doubled by splitting a single line into two through single exposure and development.
US08507174B2 Positive resist composition, pattern forming method using the composition, and compound for use in the composition
A positive resist composition comprising (A) a compound capable of generating an acid upon irradiation with an actinic ray or radiation, (B) a resin capable of increasing the solubility in an alkali developer by the action of an acid, and (C) a compound having a specific structure, which decomposes by the action of an acid to generate an acid, a pattern forming method using the positive resist composition, and a compound for use in the positive resist composition are provided as a positive resist composition exhibiting good performance in terms of pattern profile, line edge roughness, pattern collapse, sensitivity and resolution in normal exposure (dry exposure), immersion exposure and double exposure, a pattern forming method using the positive resist composition and a compound for use in the positive resist composition.
US08507172B2 Positive resist composition and pattern forming method using the positive resist composition
A positive resist composition comprises: (A) a compound capable of generating an acid upon irradiation with actinic rays or radiation; (B) a resin of which solubility in an alkali developer increases under action of an acid; and (C) a compound capable of decomposing under action of an acid to generate an acid.
US08507170B2 Image-forming method and image-forming apparatus
An image-forming method includes forming an electrostatic image on an electrostatic image bearing member which has been charged; developing the electrostatic image to form a toner image; transferring the toner image on the electrostatic image bearing member with or without mediating an intermediate transferring member onto a transfer material; and fixing the toner image on the transfer material. The electrostatic image bearing member is a photosensitive member obtained by sequentially laminating a photoconductive layer and a surface layer formed of hydrogenated amorphous silicon carbide, and a sum of an atomic density of silicon atoms and an atomic density of carbon atoms in the surface layer of the photosensitive member is 6.60×1022 atoms/cm3 or more. The toner has a binder resin and magnetic iron oxide particles, and the magnetic iron oxide particles contain Fe(2+) at a content of 20.0 mass % or more and 25.0 mass % or less.
US08507168B2 Electrostatic image-developing toner, electrostatic image developer, toner cartridge, process cartridge, and image forming apparatus
An electrostatic image developing toner that includes a toner particle including a binder resin containing a resin selected from an acrylic resin, a styrene-acrylic resin, and a styrene-(meth)acrylic acid ester copolymer. The resin has a crosslinked structure formed by using at least one of boric acid and boric acid derivatives.
US08507167B2 Toner for developing electrostatic charge image, electrostatic charge image developer, toner cartridge, process cartridge and image forming apparatus
The invention provides a toner for developing an electrostatic image including toner particles having a shape factor SF1 of 110 or more and including a binder resin, and particles of an external additive that adhere to the toner particles, wherein the particles of the external additive including first particles, and second particles which are adhered to the first particles and have a primary particle size of 0.2 times to 0.5 times as large as that of the first particles, and in an image obtained by observing the particles of the external additive with a microscope, when the projection surface area of the first particle is defined as S1 and the total of the projection surface areas of the second particles which are not hidden by the first particle is defined as S2, S2 being from 0.1 times to 0.5 times as large as S1.
US08507166B2 Surface treated toner
A toner composition includes resin core particles having outer surfaces, and surface treatment, wherein the surface treatment includes at least first metal oxide particles having a surface area equivalent average particle diameter of greater than 25 nm and a surface energy of less than 28 erg/cm2, as determined by methanol wettability midpoint at 22° C., tacked to the outer surfaces of the resin core particles, at a concentration to provide a total projected area of the first metal oxide particles sufficient to cover at least 10% of the resin core particle outer surfaces area, and wherein the toner composition comprises less than 0.013 g non-tacked surface treatment per square meter of resin core particles outer surface. A developer for developing electrostatic images includes magnetic carrier particles and toner as described above, wherein the developer comprises less than 0.013 g non-tacked surface treatment per square meter of resin core particles outer surface, that is free to transfer between the outer surface of the resin core particles and outer surfaces of the magnetic carrier particles.
US08507165B2 Black particles and a manufacturing method of the same, a black toner using the same, and a particle container and a toner container
Black particles include a black pigment; and a cyan pigment, wherein when the reflectance to light of wavelength of 420 nm and the reflectance to light of wavelength of 770 nm of plural samples are measured, the standard deviations (1σ) of the measured values are about 1 or less with respect to both wavelengths.
US08507162B2 Electrophotographic photosensitive member, process cartridge, and electrophotographic apparatus
An electrophotographic photosensitive member comprises a conductive support, an intermediate layer provided on the conductive support, and a photosensitive layer provided on the intermediate layer, in which at least one of the intermediate layer and the photosensitive layer comprises a compound represented by the following formula (1):
US08507160B2 Flare prediction method, photomask manufacturing method, semiconductor device manufacturing method, and computer-readable medium
According to one embodiment, a flare prediction method in photolithography includes determining a pattern density distribution of a pattern layout, determining an inclination of a variation in the pattern density distribution, and performing a flare calculation in a plurality of partition sizes based on the inclination of a variation in the pattern density distribution.
US08507159B2 Electron beam data storage system and method for high volume manufacturing
The present disclosure provides for many different embodiments of a charged particle beam data storage system and method. In an example, a method includes dividing a design layout into a plurality of units; creating a lookup table that maps each of the plurality of units to its position within the design layout and a data set, wherein the lookup table associates any repeating units in the plurality of units to a same data set; and exposing an energy sensitive layer to a charged particle beam based on the lookup table.
US08507153B2 Compositions, optical data storage media and methods for using the optical data storage media
There are provided compositions, optical data storage media and methods of using the optical data storage media. The compositions comprise a non-linear sensitizer comprising one or more subphthalocyanine reverse saturable absorbers capable of absorbing actinic radiation to cause upper triplet energy transfer to a reactant that undergoes a photochemical change upon triplet excitation.
US08507147B2 Proton exchange membrane and cell comprising such a membrane
A cell of a fuel cell comprises an anode, a cathode, and between the cathode and the anode, a layer of ceramic including activated boron nitride.
US08507142B2 Fuel cell system including charge status detector and operation method therefor
A fuel cell system includes a cell stack, a secondary battery, and a controller including a CPU, a main switch, and a stop button. After the main switch is turned OFF, if there is no power generation stopping command from the stop button, the CPU stops power generation in the cell stack after continuing power generation in the cell stack until a charge rate of the secondary battery becomes not lower than a first threshold value. If the charge rate is not lower than a second threshold value and is lower than the first threshold value, generation in the cell stack is stopped in response to the power generation stopping command from the stop button. If the charge rate is lower than the second threshold value, power generation in the cell stack is continued to charge the secondary battery until the charge rate becomes not lower than the second threshold value.
US08507137B2 Separator plate configuration for a fuel cell
A fuel cell includes a membrane electrode assembly comprised of a membrane sandwiched between anode and cathode catalyst structures. An anode separator plate and a cathode separator plate are arranged adjacent to the membrane electrode assembly opposite from one another. The anode and cathode separator plates include opposing sides in which one of the opposing sides of the anode and cathode respectively have fuel and oxidant flow fields in communication with the membrane. The anode separator plate is a structure having a first water permeability and is configured to permit passage of water between its opposing sides and with its flow field, and the cathode separator plate comprises a structure having a second water permeability less than the first water permeability of the anode separator plate. In one example, the anode is provided by a porous separator plate, and the cathode is provided by a non-porous, or solid, plate.
US08507133B2 Anode active material, anode, and lithium secondary battery
The principal object of the present invention is to provide an anode active material suitable for rapid charging. The present invention provides an anode active material comprising a metallic part which comprises Sn or Si and has a film thickness of 0.05 μm or less, and thereby solving the problem.
US08507126B2 Secondary battery
A secondary battery includes an electrode assembly having a first electrode, a second electrode, and a separator located between the first electrode and the second electrode; a first collector plate electrically coupled to the first electrode, wherein the first collector plate has a first fuse hole and includes at least one first reinforcement protrusion having a first reinforcement groove and being spaced from the first fuse hole; a second collector plate electrically coupled to the second electrode; a case housing the electrode assembly, the first collector plate and the second collector plate, the case having an upper opening; and a cap assembly sealing the upper opening of the case.
US08507124B2 Multi-layer, microporous membrane, battery separator and battery
The invention relates to a multi-layer, microporous membrane having appropriate permeability, pin puncture strength, shutdown temperature, shutdown speed, meltdown temperature, and thickness uniformity. The invention also relates to a battery separator formed by such multi-layer, microporous membrane, and a battery comprising such a separator. Another aspect of the invention relates to a method for making the multi-layer, microporous polyolefin membrane, a method for making a battery using such a membrane as a separator, and a method for using such a battery.
US08507120B2 Round cell battery
A round cell rechargeable battery includes a plurality of round cells arranged alongside one another and at least one output element that is electrically insulated from the round cells. The at least one output element is in the form of a rod and is curved such that the output element runs in a zigzag shape alternately along a lower face, a side wall adjacent thereto, and an upper face of the round cells and thermally conductively connects a group of the round cells for heat dissipation.
US08507116B2 Magnetic recording medium and manufacturing method thereof
According to one embodiment, a magnetic recording medium includes a substrate, a soft magnetic layer, an underlayer, a magnetic recording layer, and a protective layer, wherein the magnetic recording layer is provided with a pattern including recording portions and non-recording portions, the non-recording portions have a composition that is equal to a composition obtained by demagnetizing the recording portions, the non-recording portions contain at least one metal element selected from the group consisting of vanadium and zirconium and at least one element selected from the group consisting of nitrogen, carbon, boron and oxygen, and the at least one element selected from the group consisting of nitrogen, carbon, boron and oxygen is contained in the non-recording portions at a higher content than the content of the at least one element selected from the group consisting of nitrogen, carbon, boron and oxygen in the recording portions.
US08507114B2 Recording layer for heat assisted magnetic recording
A magnetic stack includes multiple granular layers, at least one of the multiple granular layers is a magnetic layer that includes exchange coupled magnetic grains separated by a segregant having Ms greater than 100 emu/cc. Each of the multiple granular layers have anisotropic thermal conductivity.
US08507112B2 Data recording medium for data storage and method of recording or erasing data using the same
Provided is a data recording medium having improved data recording/storage characteristics and with an improved structure to have a higher data storage capacity, and a method of recording and/or easing data using the same. The data recording medium may include a Cu electrode layer on a substrate, and a data recording layer formed of a compound including a metal and at least one non-metal selected from the group consisting of S, Se, and Te, on the Cu electrode layer. Data is recordable to or erasable from the data recording layer by changing the resistance of the data recording layer by diffusing Cu ions from the Cu electrode layer to the data recording layer or by erasing Cu ions from the data recording layer by diffusing Cu ions from the data recording layer back to the Cu electrode layer, according to a voltage pulse applied to the data recording layer.
US08507110B2 Coated cutting tool and a method of making thereof
The present invention relates to a cutting tool for metal machining with improved wear properties, comprising a cutting tool substrate of cemented carbide, cermet, ceramics or a super hard material, and a wear resistant coating, wherein the wear resistant coating comprises a PVD Ti—Si—C—N layer with a compositional gradient, and a method of making thereof.
US08507103B2 Polyethylene and process for production thereof
This invention relates to blown films produced from copolymer made by a process for polymerizing olefins in which the amount of trimethylaluminum in a methylalumoxane solution is adjusted to be from 1 to 25 mol %, prior to use as an activator, where the mol % trimethylaluminum is determined by 1H NMR of the solution prior to combination with any support. This invention also relates to a process for polymerizing olefins in which the amount of an unknown species present in a methylalumoxane solution is adjusted to be from 0.10 to 0.65 integration units prior to use as an activator, where the amount of the unknown species is determined by the 1H NMR spectra of the solution performed prior to combination with any support. Preferably, the methylalumoxane solution is present in a catalyst system also comprising a metallocene transition metal compound.
US08507100B2 Primer, conductor foil with resin, laminated sheet and method of manufacturing laminated sheet
The invention aims to provide a resin primer which can stick an insulator layer to a conductor foil whereof the surface is not much roughened with sufficient adhesive force, a conductor foil with resin, a laminated sheet and a method of manufacturing same. The resin primer of the invention comprises a resin having film-forming ability and a breaking energy of 0.15 J or more. The conductor foil with resin of the invention comprises a resin layer comprising a conductor foil and the aforesaid resin primer. Further, the laminated sheet of the invention comprises the conductor foil, an insulating layer disposed facing the conductor foil, and a resin layer comprising the aforesaid resin primer disposed between the conductor foil and insulating layer so that it is in contact therewith. This laminated sheet can be manufactured by heating and pressurizing a laminate comprising the aforesaid conductor foil with resin, and a prepreg laminated on this resin layer.
US08507095B2 Metal oxide-based fine particle and method for manufacturing the same, and resin composition
A metal oxide-based fine particle includes a metal oxide-based core region; an intermediate region formed on the outer periphery of the core region, the intermediate region having an alkoxyorganosiloxane condensate structure; and a surface region including an organic molecular chain or an organic silicon molecular chain or a reactive functional group.
US08507094B2 Superparamagnetic cluster-nano particles-porous composite bead and fabrication method thereof
The present invention relates to a composite bead and a fabrication method thereof, and particularly, to a porous composite bead comprising superparamagnetic cluster and nanoparticles, such as light-emitting nanoparticles, magnetic nanoparticles, metallic nanoparticles, metal oxide nanoparticles and the like, and a fabrication method thereof.
US08507093B2 Comminution process to produce precision wood particles of uniform size and shape with disrupted grain structure from wood chips
A process of comminution of wood chips (C) having a grain direction to produce a mixture of wood particles (P), wherein the wood chips are characterized by an average length dimension (LC) as measured substantially parallel to the grain, an average width dimension (WC) as measured normal to LC and aligned cross grain, and an average height dimension (HC) as measured normal to WC and LC, and wherein the comminution process comprises the step of feeding the wood chips in a direction of travel substantially randomly to the grain direction through a counter rotating pair of intermeshing arrays of cutting discs (D) arrayed axially perpendicular to the direction of wood chip travel, wherein the cutting discs have a uniform thickness (TD), and wherein at least one of LC, WC, and HC is greater than TD.
US08507091B2 Method of reducing odor of composite resin particles, and composite resin particles
A method of reducing an odor of composite resin particles comprising the step of: fluidizing the composite resin particles, which contain a polyolefin-based resin and a polystyrene-based resin and which are used for producing an expanded molded article, in a container with a gas that is blown thereinto from its bottom and that has a temperature of (T−40)° C. to (T−10)° C. (T is a softening temperature of the composite resin particles), to reduce the odor generated from a raw material of the composite resin particles and generated according to a method of the composite resin particles, wherein the composite resin particles whose odor is reduced are impregnated with a blowing agent; and the resultant is pre-expanded and then subject to an in-mold forming to make the expanded molded article have an odor strength of 3 or less in average value in odor test in which odor of an isovaleric acid diluted 100000 times is defined as 3, which means a reference odor, within 0 to 5 levels of the odor strength.
US08507089B2 Articles with porous particles for security purposes
An article comprises one or more porous particles. Each porous particle comprises a polymer that provides a continuous solid phase including an external particle surface, and first and second discrete pores that are isolated from each other and dispersed within the continuous solid phase. The porous particle further comprises a first marker material present in the first discrete pores, and a second marker material that is detectably different from the first marker material and is present within the second discrete pores. The marker materials can provide a means for identifying documents, clothing, or other articles as genuine, and providing a detectable security system.
US08507088B2 Porous particles with multiple markers
Polymeric porous particles have a continuous solid phase and at least two different internal pores that are isolated from each other within the continuous phase. At least one set of discrete pores contains a marker material, and some instances, each set of discrete pores contain different pores marker materials that are isolated from each other. These marker materials are detectably different from each other. The porous particles can be spherical or non-spherical and can be used in any situation where the detectably different marker materials can be evaluated.
US08507083B2 Embossed fibrous structures
Fibrous structures that exhibit a Geometric Mean Elongation of greater than 15.8% as measured according to the Elongation Test Method are provided.
US08507082B2 CVD coated polycrystalline c-BN cutting tools
In one aspect, the present invention provides coated cutting tools comprising a PcBN substrate wherein a layer of single phase α-alumina is deposited by chemical vapor deposition directly on one or more surfaces of the substrate.
US08507081B2 Absorbing article with zones of different surface properties
An absorbing element having an adhesive surface showing adhesive properties for adhering to a substrate wherein at least a part of the surface has been treated, resulting in alteration of the surface properties of the heat treated part of the surface. By heat treatment, it is possible to provide an adhesive surface having parts showing different colors, water absorption properties, and/or adhesive properties. These parts include grottos in a first facade of the absorbing element that are at least 5 μm in diameter, with an average size of the grottos being less than 300 μm.
US08507080B2 Thermoplastic-thermosetting composite and method for bonding a thermoplastic material to a thermosetting material
Composite with a first part composed of a thermoset material and with a second part composed of a thermoplastic material, and with an adhesion-promoter layer located between these, where the first part has been bonded by way of the adhesion-promoter layer to the second part, and where the adhesion-promoter layer comprises pyrolytically deposited semiconductor oxides and/or pyrolytically deposited metal oxides.
US08507071B1 Sheet insulator with improved resistance to heat transfer by conduction, convection and radiation
A sheet insulator is attached to an item of wearing apparel to provide thermal insulation. The sheet insulator has a fiber reinforced aerogel composite encapsulated within a plastic sheeting. The plastic sheeting is secured to the aerogel composite, surface to surface. The plastic sheeting and the aerogel composite have surface upsets such as elongated depressions or burrows positioned and oriented at a flexing position of the wearing apparel so that the sheet insulator is able to flex with the apparel enabling a more natural movement of the apparel.
US08507064B2 Printable sheet assembly
A printable sheet assembly having a facestock that is provided with a plurality of cards including a card whose perimeter is defined by first and second horizontal through-cut lines and first and second vertical through-cut lines, the intersection of the first horizontal through-cut line and the first vertical through-cut line defining a first corner, the intersection of the first horizontal through-cut line and the second vertical through-cut line defining a second card corner. A liner sheet strip is on a back side surface of the facestock. The liner sheet strip covers the first horizontal through-cut line and is wider at one of the card corners than along the first horizontal through-cut line at an area centrally disposed between the card corners, thereby exposing a portion of a back side surface the card, and the liner sheet strip covering portions of the vertical through-cut lines between the horizontal through-cut lines.
US08507063B2 Pet containers with enhanced thermal properties
The present invention provides a blow molded heat set PET container having enhanced thermal properties and a first glass transition temperature and a second endothermic transition temperature substantially higher than the glass transition temperature.
US08507061B2 Wet friction material for blow molded articles
A blow molded article comprising a housing defining a hollow interior. The housing comprises a blow molded thermoplastic polymer and a thermoplastic elastomer on a portion of the blow molded thermoplastic polymer. The thermoplastic elastomer is polar and hydrophilic. A coefficient of friction of the thermoplastic elastomer when wet is higher than a coefficient of friction of the blow molded thermoplastic polymer when wet.
US08507055B2 Laser or dye sublimation printable image transfer paper
An image transfer paper including a substrate layer, an image layer positioned relative to the substrate layer, the image layer including at least one of a polyester and a polyurethane and at least one of a micronized polytetrafluoroethylene and a micronized polyethylene, and a release layer positioned between the substrate layer and the image layer, the release layer including a wax component and at least one of a fluoro phosphate ester and a perfluoro phosphate ester.
US08507054B2 Media for inkjet printing
An ink-jet recording medium is disclosed which comprises a paper substrate having a surface for receiving an ink-jet ink containing a pigmented colorant. The surface is treated with at least one co-crystalline salt, which become associated with the substrate surface. The co-crystalline salt is capable of crashing pigmented colorants on the paper surface, and its use may help protect paper manufacturing equipment from corrosion.
US08507052B2 Ferroelectric liquid crystal mixture with organic ion pair compound
Ferroelectric liquid crystal compositions including organic ion pair compounds wherein image sticking is reduced or eliminated. Use of the ferroelectric liquid crystal compositions in a ferroelectric liquid crystal display device allows for rapid image refresh rates without required a DC-balancing algorithm. The organic ion pair compounds provide electrical resistivity values for the compositions that result in reduced image sticking when the compositions are used in FLC display devices.
US08507051B2 Polycrystalline silicon producing method
A polycrystalline silicon producing method includes: the first process and the second process. In the first process, a surface temperature is maintained at a predetermined range by adjusting the current value to the silicon seed rod, and the raw material gas is supplied while maintaining a supply amount of chlorosilanes per square millimeter of the surface of the rod in a predetermined range until a temperature of the center portion of the rod reaches a predetermined temperature lower than the melting point of the polycrystalline silicon, and in the second process, a previously determined current value is set corresponding to a rod diameter and the supply amount of the raw material gas per square millimeter of the surface of the rod is decreased to maintain the surface temperature and the temperature of the center portion of the rod at predetermined ranges, respectively.
US08507050B2 Methods for depositing ultra thin coatings exhibiting low haze and methods for the preparation of such coatings
Disclosed are methods for depositing an ultra thin coating that exhibits both low haze (high transparency) and strong color (high optical density at a given film thickness). Also disclosed are methods for making radiation curable coating compositions comprising polymer-enclosed particles that are suitable for producing ultra thin coatings.
US08507046B2 Method of creating a fluid layer in the submicrometer range
A method of creating a fluid layer in the micrometer range includes transferring a fluid between substrates and forming a fluid layer. A surface energy of a first substrate releasing the fluid is higher than a surface energy of a fluid on the first substrate to create a first fluid deposit on the first substrate. A surface energy of a second substrate accepting the fluid is lower than a surface energy of a fluid on the second substrate to create a second fluid deposit on the second substrate that is reduced as compared to the first fluid deposit. A surface energy of a third substrate accepting the fluid is higher than a surface energy of a fluid on the third substrate to create a substantially homogeneous third fluid deposit on the third substrate that forms the fluid layer.
US08507043B2 Non-electrolytic method for metallizing a substrate by the reduction of metallic salt(s) and the spraying of aerosol(s)
The invention relates to a non-electrolytic method for metallizing a substrate by projecting an aerosol containing a solution of an oxidant metallic cation and of a reducing agent; said method comprising a step of -a- wetting the substrate; starting to project a metallisation according to a succession of projecting phases alternating with relaxing phases: (i) by adjusting the duration Dp of the projection phases and the duration Dr of the relaxing phases from a metallisation constant k intrinsic for each metal; and (ii) by adjusting the projection flow-rate. The metallisation projection is carried out dynamically by displacing projection means relative to the substrate in order to carry out a periodical scanning, wherein Dp correspond to the duration during which the surface unit in question is submitted to the continuous projection of the aerosol and Dr corresponds to the duration during which the part is not submitted to projection.
US08507042B2 Application of insulating coating
Systems and methods for discontinuously applying an insulating primer to a carbon fiber reinforced plastic (CFRP) component are disclosed. In one embodiment, a method for mitigating electrical surface discharges from a CFRP component includes first applying an insulating primer to a metallic component. Next, an insulating primer is applied discontinuously to the CFRP component adjacent the metallic component. The discontinuous application of the insulating primer forms a primed portions and unprimed portions. The unprimed portions are configured to enable electrostatic dissipation.
US08507041B2 Pigmented phase change inks containing low molecular weight pigment dispersants
An ink comprising an ink vehicle; pigment particles; and a dispersant; wherein the dispersant stabilizes the pigment particles; and wherein the dispersant is a compound of the formula or a mixture thereof, wherein R and R′ are independently selected from alkyl, arylalkyl, or alkylaryl with from about 18 to about 60 carbon atoms and wherein m is an integer of from about 1 to about 30.
US08507040B2 Binary and ternary metal chalcogenide materials and method of making and using same
This invention discloses the synthesis of metal chalcogenides using chemical vapor deposition (CVD) process, atomic layer deposition (ALD) process, or wet solution process. Ligand exchange reactions of organosilyltellurium or organosilylselenium with a series of metal compounds having neucleophilic substituents generate metal chalcogenides. This chemistry is used to deposit germanium-antimony-tellurium (GeSbTe) and germanium-antimony-selenium (GeSbSe) films or other tellurium and selenium based metal compounds for phase change memory and photovoltaic devices.
US08507037B2 Digital manufacture of an gas or liquid separation device
Printing one or more layers using toner and/or laminates to form one or more multi-channeled layers, with a particular pattern, including forming a desired image, for example, electrographically, on a receiver member. The multi layered channel printing apparatus and related method and print incorporates one or more static layers, and one or more moveable layers that allow a fluid to move through the micro channels via an opening or through a direct fill. It also incorporates particles in the channels to act as a packing material for separation of components of samples. The packing material can either be applied directly or using the electrographic printing process. An optional capping layer or substrate may then be applied.
US08507036B2 Process for producing rigid open-cell foam
To provide a process capable of producing a light-weight rigid open-cell foam by a spraying method using mainly or solely water as a blowing agent, wherein a polyol system liquid is excellent in storage stability even when the blowing agent is used in a large amount, and the foam is excellent in dimensional stability without sagging and capable of forming a uniform thermal insulation layer having an excellent appearance for the purpose of constructing a whole constructions.
US08507035B2 Method and apparatus for coating a complex object and composite comprising the coated object
Disclosed are coating apparatus and coating methods to uniformly coat complex objects. The coating apparatus comprises first, second and/or third gimbals connected to rotational mechanisms to allow rotation of the gimbals around or about first, second and/or third axis. When three gimbals are used, an object holder is connected to the third gimbal. When an object is present in the object holder, it can be immersed in a coating solution to form a coated object. After removal from the coating solution, the coated object is then rotated around or about two or three axes which produces a multidirectional centrifugal force which causes the coating solution to spread evenly over the surface of the object to produce a uniform thin film. Coating methods based on the forgoing are also disclosed.
US08507032B2 Orientation of nanotubes containing magnetic nanoparticles in a magnetic storage medium
A magnetic storage medium is formed of magnetic nanoparticles that are encapsulated within nanotubes (e.g., carbon nanotubes), which are arranged in a substrate to facilitate the reading and writing of information by a read/write head. The substrate may be flexible or rigid. Information is stored on the magnetic nanoparticles via the read/write head of a storage device. These magnetic nanoparticles are arranged into data tracks to store information through encapsulation within the carbon nanotubes. As carbon nanotubes are bendable, the carbon nanotubes may be arranged on flexible or rigid substrates, such as a polymer tape or disk for flexible media, or a glass substrate for rigid disk. A polymer may assist holding the nano-particle filled carbon-tubes to the substrate. Magnetic fields may be applied to draw the carbon nanotubes into data tracks and orient the carbon nanotubes within the data tracks.
US08507029B2 Backing sheet for photovoltaic modules
A protective backing sheet for photovoltaic modules is provided. The backing sheet has a layer including fluoropolymer which is cured on a substrate, and the layer includes boron nitride. The amount of boron nitride contained in the layer is within the range of 2 to 30.0% by weight, and preferably in the range of 5 to 10%. Also, the layer including fluoropolymer may further include a titanium dioxide.
US08507024B2 Method of treating food and food obtained by this method
A method of treating food capable of easily softening or pulverizing food in a short time without losing nutrients is provided. A shock wave (SW) generated in a shock wave source is applied to food such as an apple or tea leaves to soften or pulverize the food. A large mechanical load is not necessary, so the food is easily softened or pulverized. Moreover, it is not necessary to heat the food, so the food is softened or pulverized in a short time without losing nutrients in the food due to heat during heating.
US08507023B2 Healthy drink and a method for improving stability of a drink
A method for improving the stability of a drink includes providing an oat based material, which contains from 0.01% to 40% by dry weight of starch, which includes a degraded starch present in an amount from 20 wt. % to 100 wt. % of the starch. The degraded starch includes an amyloglucosidase-degraded starch. A berry juice selected from a group is mixed with the oat based material and water to obtain a drink comprising the berry juice in an amount from 5 to 40% by weight, the oat based material as dry matter in an amount from 3 to 30% by weight and the starch in an amount of 0.01% to 2.5% by weight of the starch.
US08507022B2 High-purity rebaudioside D and low-calorie carbonated lemon-flavored beverage containing the same
The invention provides methods of purifying Rebaudioside D from the Stevia rebaudiana Bertoni plant extract along with Rebaudioside A. The methods are useful for producing high purity Rebaudioside D and Rebaudioside A. The invention further provides a low-calorie carbonated lemon-flavored beverage containing the purified Rebaudioside D and a process for making the low-calorie carbonated lemon-flavored beverage containing the purified Rebaudioside D.
US08507019B2 Mycotoxin binder
A mycotoxin binder is disclosed characterized by 45% or more humic acid, maximum solubility of 20% at pH between 1.5 and 7.0, and an in vitro mycotoxin binding efficiency of at least 80% and preferably 90% with adsorption of at least 85% at pH 3.0 and desorption less than 10% at pH 6.8.
US08507012B2 Formulations comprising extracts from primitive plant species (mosses, ferns and lichens) to treat and prevent cancers
Disclosed are extracts prepared from primitive plants and fungi that have anti-cancer properties. The extracts are prepared by pulverizing the biological matter in a diluent. The extract can be administered to an individual or animal to kill cancer cells, prevent growth of cancer cells and treat cancer. The extracts may be used in combination with other therapeutic protocols.
US08507011B2 Method for suppressing or preventing fibrous adhesion formation using a multicomponent aqueous oxychlorine composition prepared on-site
A composition and method are described for suppressing or preventing fibrous adhesion formation using a multicomponent aqueous oxychlorine composition. Fibrous adhesions typically form during healing of tissue, for example following a surgical procedure. A multicomponent oxychlorine composition is provided for irrigating the tissue which minimizes post-surgical adhesion formation, the composition containing both chlorine dioxide and chlorite ion, and a complexion thereof. The chlorine dioxide level generally is in an effective range of ClO2 concentration from about 10 ppm to a maximum of about 110 ppm. In a preferred embodiment, a physiological composition is provided in a thickened form to increase retention in the area being treated. The composition is preferably based on a standard saline solution converted to the oxychlorine composition just prior to use by sequential addition of aqueous concentrates of a chlorite salt, a hypochlorite salt combined with a physiological buffer-producing salt of a multibasic acid, and an acidifying agent, optionally including a thickening agent.
US08507009B2 Colonic purgative composition with soluble binding agent
This invention relates to novel colonic purgative compositions in a solid dosage form, comprising at least one purgative and at least one soluble, or soluble, nonfermentable binder, such as polyethylene glycol. Further, this invention relates to methods of using the colonic purgative compositions. The present compositions and methods are designed to improve patient tolerance and compliance, while at the same time improving the quality of bowel cleansing. The formulations and methods of this invention are particularly useful to cleanse the bowel prior to diagnostic and surgical procedures and can also be employed in lower dosages as a laxative to promote elimination and/or to relieve constipation.
US08507003B2 Compressed tablets comprising microcapsules with modified release
A multi(micro)particulate tablet is provided comprising microparticles which comprise a mechanically non-deformable core of active principle (AP). The tablet is formed from reservoir microcapsules with prolonged release of the AP, which are each made up of a non-deformable core comprising AP and covered with at least one film coating controlling release of the AP in vivo. The microcapsules have a particle size of between 50 and 1000 microns and are coated with at least one outer overcoating envelope comprising at least one deformable organic constituent having a melting point of between 40° C. and 120° C. The envelope allows the prolonged release of the AP in vivo without modification of the release profile when the microcapsules are compressed to form a tablet, even for microparticles not specifically formulated for compression.
US08507001B2 Dosage forms for tamper prone therapeutic agents
A dosage form from which a burst release of a drug contained within a tampered dosage form is reduced or retarded by the presence in or on the dosage form of a TPTA (Tamper Prone Therapeutic Agent) trap. If the dosage form has not been tampered with, the TPTA trap does not significantly interfere with the rate of release of the drug from the dosage form. However, if the dosage form has been physically tampered with, the TPTA trap reduces or retards burst release of the drug from the dosage form.
US08506999B2 Pharmaceutical tablets comprising a plurality of segments
Deeply scored pharmaceutical tablets are disclosed, along with pharmaceutical tablets with a score in a segment that adjoins a segment lacking a pharmacologically effective dose of any drug.
US08506995B2 Coenzyme Q10 formulation and process methodology for soft gel capsules manufacturing
A formulation of Coenzyme Q10, beta-carotenes, Vitamin E, and medium chain triglycerides in rice bran oil and an optional thickener, such as bee's wax, is provided in a soft gel capsule so that a maximum of the Coenzyme Q10 is absorbed by the human body. Generally, about 60 mg of Coenzyme Q10 is the normal amount provided daily to a healthy sedentary adult.
US08506992B2 Percutaneous absorption-type pharmaceutical preparations
A percutaneous absorption-type pharmaceutical preparation containing a sublimation drug is provided, where from a plaster layer, a drug is released as volatile substance with a lapse of time, but the released drug has no adverse effect on the handling of the preparation, and the quality of the preparation is maintained in storage over a long period of time. A percutaneous absorption-type pharmaceutical preparation, which comprises: a support comprising a plastic film and a nonwoven fabric; and a plaster layer containing a sublimation drug, wherein the plastic film and the nonwoven fabric are laminated with an adhesive having a glass transition temperature of 10° C. or higher, and the plaster layer is laminated on opposite side of the plastic film surface that the nonwoven fabric is laminated with.
US08506988B2 Process for making a multicomponent bioactive intravaginal ring
A process for making a multicomponent microbicidal contraceptive intravaginal ringed-mesh device that includes forming a polymeric, fibrous mesh and adjoining a reinforcing yarn about the periphery of the fibrous mesh. The process further involves forming a polymeric ring matrix, that includes at least one contraceptive agent on the reinforced fibrous mesh, thereby encasing the reinforcing yarn and the mesh periphery, and applying at least one bioactive agent to the ringed-mesh.
US08506981B1 Compositions and their use in bone healing
The present invention is directed to implantable compositions comprising substantially spherical bioactive glass particles.
US08506979B2 Near-infrared electromagnetic modification of cellular steady-state membrane potentials
Systems and methods are disclosed herein for applying near-infrared optical energies and dosimetries to alter the bioenergetic steady-state trans-membrane and mitochondrial potentials (ΔΨ-steady) of all irradiated cells through an optical depolarization effect. This depolarization causes a concomitant decrease in the absolute value of the trans-membrane potentials ΔΨ of the irradiated mitochondrial and plasma membranes. Many cellular anabolic reactions and drug-resistance mechanisms can be rendered less functional and/or mitigated by a decrease in a membrane potential ΔΨ, the affiliated weakening of the proton motive force Δp, and the associated lowered phosphorylation potential ΔGp. Within the area of irradiation exposure, the decrease in membrane potentials ΔΨ will occur in bacterial, fungal and mammalian cells in unison. This membrane depolarization provides the ability to potentiate antimicrobial, antifungal and/or antineoplastic drugs against only targeted undesirable cells.
US08506978B2 Bacteriostatic tissue product
A tissue product comprising an additive composition onto at least the surface of a fibrous article in order to increase the surface potential of the article, while retaining or improving manufacturing efficiency is disclosed. The additive composition comprises a bacteriostatic component and more preferably a water-soluble adhesive component and a bacteriostatic component. In some aspects, the additive may also contain additional water-soluble modifier components. Tissue products according to the present disclosure can attract and trap negatively charged matter, such as bacteria, into the tissue web. As such, tissue products can pickup bacteria from a surface and substantially hold the bacteria in the sheet to help prevent spreading bacteria to other surfaces.
US08506972B2 Highly biocompatible dual thermogelling chitosan/glucosamine salt compositions
The present disclosure relates to a chitosan solution neutralized with amino-sugar carbonate buffering solution or amino-sugar phosphate buffering solution or phosphorylated aminosugar buffering solution. The resulting thermogelling chitosan composition is highly biocompatible, isotonic and has the ability to rapidly turn into gel upon heating to the body temperature. It provides a novel chitosan-based composition to suitable for drug delivery, cell delivery and repair or regeneration of tissues and organs as well as other clinical treatment.
US08506970B2 Dose and localization of botulinum toxins in skin and muscle
A novel dosing regimen for the administration of botulinum toxin based on the pattern, quantity, and location of neuromuscular junctions in the target tissue. Because the number of neuromuscular junctions in a target tissue remains generally stable throughout life and because the pharmacological effect of botulinum toxin is localized at the neuromuscular junction, dosing efficacy is unaffected by muscle mass, age of the patient, or body weight.
US08506969B2 Efficient cell culture system for hepatitis C virus genotype 7a
Genotype 7a has been identified recently, thus not much is known about the biology of this new, major HCV genotype. The present inventors developed hepatitis C virus 7a/2a intergenotypic recombinants in which the JFH1 structural genes (Core, E1 and E2), p7 and the complete NS2 were replaced by the corresponding genes of the genotype 7a strain QC69 and characterized them in Huh7.5 cells. Sequence analysis of 7a/JFH1 recombinants recovered after viral passage in Huh7.5 cells following 4 independent transfection experiments revealed adaptive mutations in Core, E2, NS2, NS5A and NS5B. In reverse genetic studies the importance of these mutations for improved growth kinetics was shown. Adapted 7a/JFH1 viruses showed growth kinetics, infectivity and RNA titers comparable to a previously developed 3a/JFH1 reference virus. Conclusion: The developed 7a/JFH1 viruses provide a robust in vitro tool for research in HCV genotype 7, including vaccine studies and functional analyses.
US08506968B2 SARS vaccine compositions and methods of making and using them
Described is a composition and method for reducing the occurrence and severity of infectious diseases, especially infectious diseases such as SARS, in which lipid-containing infectious viral organisms are found in biological fluids, such as blood. The present invention employs solvents useful for extracting lipids from the lipid-containing infectious viral organism thereby creating immunogenic modified, partially delipidated viral particles with reduced infectivity. The present invention provides delipidated viral vaccine compositions, such as therapeutic vaccine compositions, comprising these modified, partially delipidated viral particles with reduced infectivity, optionally combined with a pharmaceutically acceptable carrier or an immunostimulant. The vaccine composition is administered to a patient to provide protection against the lipid-containing infectious viral organism or, in case of a therapeutic vaccine, to treat or alleviate infection against the lipid-containing infections viral organism. The vaccine compositions of the present invention include combination vaccines of modified viral particles obtained from one or more strains of a virus and/or one or more types of virus.
US08506963B2 Anti-EFGRv3 monoclonal antibody
The invention provides specific binding proteins and the uses thereof. Particularly, the present invention provides a monoclonal antibody which can effectively bind to epidermal growth factor receptor variant type III (EGFRvIII) or can partially bind to the epidermal growth factor receptor (EGFR) over-expressed in cells, but not bind to EGFR normally-expressed in cells. Furthermore, the present invention said antibody has obvious therapeutic effect on a tumor cell line expressing the EGFRvIII. The invention also provides a method for preparing said monoclonal antibody and a pharmaceutical composition comprising said monoclonal antibody.
US08506962B2 Sustained release drug delivery systems comprising a water soluble therapeutic agent and a release modifier
A biocompatible, sustained release intraocular drug delivery system comprising a protein or polynucleotide therapeutic agent, a polymeric carrier for the therapeutic agent and a long chain fatty alcohol release modifier. The biocompatible, sustained release intraocular drug delivery system can be used to treat an ocular condition.
US08506960B2 Antibody molecule for human GM-CSF receptor alpha
Binding members for alpha chain of receptor for granulocyte macrophage colony stimulating factor (GM-CSFRα), especially antibody molecules. Use of the binding members in treating inflammatory and autoimmune diseases, e.g. rheumatoid arthritis, asthma, allergic response, multiple sclerosis, myeloid leukaemia and atherosclerosis.
US08506959B2 Prevention and treatment of synucleinopathic and amyloidogenic disease
The invention provides improved agents and methods for treatment of diseases associated with synucleinopathic diseases, including Lewy bodies of alpha-synuclein in the brain of a patient. Such methods entail administering agents that induce a beneficial immunogenic response against the Lewy body. The methods are particularly useful for prophylactic and therapeutic treatment of Parkinson's disease.
US08506958B2 Methods for treating TWEAK-related conditions
The present invention provides methods and agents for the treatment of TWEAK-related conditions, including cardiac, liver, kidney, lung, adipose, skeletal, muscle, neuronal, bone and cartilage conditions. The invention also provides methods for identifying TWEAK agonists or antagonists for the treatment of TWEAK-related conditions. Additionally, the invention provides transgenic animals that express an exogenous DNA encoding a TWEAK polypeptide, or fragments, analogs, or muteins thereof, and methods for using such animals to identify TWEAK agonists or antagonists. The invention further provides methods for diagnosing a disease based on TWEAK expression. The invention also provides methods for affecting cellular differentiation of progenitor cells using TWEAK polypeptides, agonists, or antagonists.
US08506953B2 Use and methods for preventing and/or treating oral malodour
Described is a microorganism belonging to the group of lactic acid bacteria which is able to drastically reduce the peptide concentration in saliva thereby depleting the substrate used by anaerobic microorganisms of the oral micro-flora which are the causative agent for oral malodour. Moreover, described is a microorganism belonging to the group of lactic acid bacteria which is able to stimulate the growth of Streptococcus salivarius but does not stimulate the growth of Streptococcus mutans and/or Porphyromonas gingivalis. Also described are compositions containing the above-mentioned microorganisms, their use for preventing and/or treating oral malodour and/or halitosis and to methods for preventing and/or treating oral malodour and/or halitosis.
US08506950B2 Degradable microcapsules
The invention relates to microcapsules consisting of a polymer degradable by a polypeptide comprising a drug or other compound of interest and a genetically engineered cell expressing said polypeptide in response to a triggering compound, and to methods of directed release of the compound of interest. The preferred polymer is optionally modified cellulose sulfate/poly-diallyl-dimethyl-ammonium chloride. Such microcapsules are non-toxic, do not elicit an immunological response and have an extended half-life time in mammals. The expression system for cellulase is, for example, based on TET and doxycycline, or E.REX and erythromycin. In another example, expression of cellulase is triggered by luteinizing hormone, which can be used for artificial insemination with microcapsules carrying sperm.
US08506946B2 Compositions and methods for attracting noctuid moths
The invention provides compositions for attracting noctuid moths, which include at least one pheromone and at least one synergist. The synergist is a naturally-occurring phytochemical compound. The synergist is preferably β-caryophyllene, iso-caryophyllene, α-humulene, or combinations thereof. The invention also provides traps containing the composition for attracting noctuid moths, and methods for attracting, capturing, killing or sterilizing noctuid moths using the composition.
US08506940B2 Aqueous compositions comprising vesicles having certain vesicle permeability
Compositions for effectively delivering a water-soluble active material to a surface comprise: (a) from about 1% to about 30%, by weight of the composition, of a dialkyl quaternary ammonium compound having the formula: wherein R1 and R2 are independently C12 to C20 saturated alkyl chains; Y is wherein R4 is ethyl or isopropyl; R3 and R5 are independently methyl, ethyl, hydroxyethyl, or hydroxypropyl; m is 1, 2, or 3; n is 1 or 2; p is 0 or 1; and X− is a suitable anion; (b) from about 0.01% to about 10%, by weight of the composition, of water-soluble active material having a ClogP of less than about 2.0; and (c) at least about 60%, by weight of the composition, of water; wherein the compositions contain vesicles having a vesicle permeability index of less than about 1.3. Processes to make the compositions comprise the steps of dispersing the dialkyl quaternary ammonium compound and the water-soluble active material in an aqueous solution to form vesicles having a vesicle permeability index of less than about 1.3.
US08506938B2 Compound applying to skin and a method making the same
A compound applying to skin and a method making the same comprises certain proportions for following first components: Dimethicone Crosspolymer, Dimethicone/Vinyl Dimethicone Crosspolymer, Cyclotetrasiloxane, Dimethicone, Cetyl PEG/PPG-15/15 Butyl Ether Dimethicone, Squalane, and Titanium Dioxide. Second components, third components, and fourth components with specific proportions as claimed are timely added in the first components. Sequentially mixing, heating, and dissolving the afore components would bring about the compound that keeps skin from sun exposure and provides functions of moisturizing, anti-wrinkle, spots clearing, blushers, anti-acnes, and whitening.
US08506937B2 Artificial saliva comprising hyaluronic acid
Provided is artificial saliva including hyaluronic acid (HA) comprising 0.4 to 0.6 mg/ml of hyaluronic acid (HA), based on 100 parts by weight of the HA, 10 to 12 parts by weight of lysozyme, and 7 to 9 parts by weight of peroxidase. The artificial saliva may be used to treat xerostomia or oral candidiasis and can be effectively used to prevent or treat complications cased by reduced secretion of saliva, since the artificial saliva is in a physiological range of human saliva and shows adequate antimicrobial activities.
US08506933B2 Methods of detecting a neurological condition via analysis of circulating phagocytes
The present invention features methods of monitoring or detecting a neurological or inflammatory condition in a patient. The method comprises (1) obtaining from the patient a fluid sample from outside of a brain tissue of the patient, wherein the fluid sample contains a circulating phagocyte, and (2) detecting for one or more biomarkers (e.g., a panel of biomarkers) inside the phagocyte, wherein the biomarker is associated with the respective neurological or inflammatory condition.
US08506932B2 Tetracyclic indole derivatives as in vivo imaging agents and having peripheralbenzodiazepine receptor affinity (PBR)
The present invention provides novel tetracyclic indole compounds of Formula (I) either as in vivo imaging agents or as therapeutic agents. A method for the preparation of the in vivo imaging agent compound is also provided by the invention, as well as a precursor for use in said method. Pharmaceutical compositions comprising the compounds of the invention are additionally provided. Where the pharmaceutical composition comprises a compound suitable for in vivo imaging, a kit is provided for the preparation of the pharmaceutical composition. In a further aspect, use of the compound for in vivo imaging or treatment of conditions associated with PBR is provided.
US08506931B2 Perylenequinone derivatives and uses thereof
The present invention relates to compounds which are perylenequinone derivatives, their stereoisomers and atropisomers. These compounds can be particularly useful as photosensitizers or sononsensitizers in photodynamic or sonodynamic therapy. The invention also relates to various methods for using these compounds in photodynamic and/or sonodynamic therapy. The compounds also are useful as therapeutic agents for treating various hyperproliferative disorders.
US08506929B2 Styrylpyridine derivatives and their use for binding and imaging amyloid plaques
This invention relates to a method of imaging amyloid deposits and to styrylpyridine compounds, and methods of making radiolabeled styrylpyridine compounds useful in imaging amyloid deposits. This invention also relates to compounds, and methods of making compounds for inhibiting the aggregation of amyloid proteins to form amyloid deposits, and a method of delivering a therapeutic agent to amyloid deposits.
US08506927B2 Pegylated fluorobenzamide analogues, their synthesis and use in diagnostic imaging
Pegylated fluoroalkoxybenzamide compounds which selectively bind Sigma-2 receptors are disclosed. These compounds, when labeled with a positron-emitting radioisotope such as 18F, can be used as radiotracers for medical imaging such as imaging of tumors by positron emission tomography (PET). In addition, these compounds, when labeled with 123I, can be used as radiotracers for imaging of tumors by single photon emission computed tomography (SPECT). Methods for synthesis of these compounds are also disclosed.
US08506924B2 Process and apparatus for preparing acetylene and synthesis gas
A process for preparing acetylene and synthesis gas by partial oxidation of hydrocarbons with oxygen, by first separately preheating the hydrocarbon gas and oxygen gas, and then reacting the gases and cooling the products rapidly. The reactor wall is blanketed with a purge gas stream, introduced through a plurality of feed lines. These feed lines deliver purge gas in a vector direction within a 10° angle of the main flow direction of the reactive gas stream. The purge gas is delivered at multiple stages relative to the main flow direction of the reactive gas stream, and the free cross section of the firing space available to the reactive gas stream, at the height of the feed lines of the purge gas stream, is approximately constant.
US08506923B2 Nanostructured sorbent materials for capturing environmental mercury vapor
The present invention is a method and material for using a sorbent material to capture and stabilize mercury. The method for using sorbent material to capture and stabilize mercury contains the following steps. First, the sorbent material is provided. The sorbent material, in one embodiment, is nano-particles. In a preferred embodiment, the nano-particles are unstabilized nano-Se. Next, the sorbent material is exposed to mercury in an environment. As a result, the sorbent material captures and stabilizes mercury from the environment. In the preferred embodiment, the environment is an indoor space in which a fluorescent has broken.
US08506922B2 Composite sintering materials using carbon nanotube and manufacturing method thereof
The present invention relates to a composite sintering materials using a carbon nanotube (including carbide nano particles, hereinafter the same) and a manufacturing method thereof, the method comprises the steps of: combining or generating carbon nanotubes in metal powders, a compacted product, or a sintered product; growing and alloying the carbon nanotubes by compacting or sintering the metal powders, the compacted product, or the sintered product; and strengthening the mechanical characteristics by repeatedly performing the sintering process and the combining process or the generating process of the carbon nanotubes. The composite sintering materials using carbon nanotubes of the present invention have excellent mechanical, thermal, and electric and electronic characteristics as well as have effects of material cost reduction and manufacturing cost reduction due to reduced sintering temperature so that they are useful as materials for automotive parts, electric and electronic arts, space and aircraft parts, and molding and cutting tools, all of which include the composite sintering materials using carbon nanotubes.
US08506921B2 Production of vertical arrays of small diameter single-walled carbon nanotubes
A hot filament chemical vapor deposition method has been developed to grow at least one vertical single-walled carbon nanotube (SWNT). In general, various embodiments of the present invention disclose novel processes for growing and/or producing enhanced nanotube carpets with decreased diameters as compared to the prior art.
US08506917B2 Gas treatment method and apparatus for circulating fluidized-bed gasification system
In a circulating fluidized-bed gasification system, an ammonia-off gas 30 from an ammonia remover 25 is fed to a catalytic denitrator 15 with a flow rate regulated such that a molar ratio of the ammonia in the ammonia off-gas 30 from the ammonia recover 25 to nitrogen oxides in an exhaust gas 6 from a combustion furnace 1 is kept within a setting range, and a reminder of the ammonia off-gas 30 is fed to the combustion furnace 1.
US08506916B2 Methods and devices for reducing hazardous air pollutants
The disclosure provides methods and systems for sequestering and/or reducing sulfur oxides, nitrogen oxides and/or carbon dioxide present in industrial effluent fluid streams. A solid particulate material comprising a slag component, a binder component (distinct from the slag component), and optionally water is formed and then contacted with the effluent fluid stream to reduce at least one of the sulfur oxides, nitrogen oxides, and/or carbon dioxide. The contacting of the effluent stream may occur in a packed bed reactor with the solid dry particulate material. Methods of reducing pollutants from exhaust generated by combustion sources, lime and/or cement kilns, iron and/or steel furnaces, and the like are provided.
US08506913B2 Acidic gas absorbent, acidic gas removal device, and acidic gas removal method
An acidic gas absorbent having a high acidic gas absorption capacity, that is, a high acidic gas absorption amount and a high acidic gas absorption rate, an acidic gas absorption device, and a method for absorbing an acidic gas, are provided. An acidic gas absorbent containing an azabicyclo compound and a primary or secondary amine compound; an acidic gas absorbent containing a heteroaromatic ring compound and a primary or secondary amine compound; an acidic gas removal device using these acidic gas absorbents; and a method for removing an acidic gas are disclosed.
US08506911B2 Compositions and methods for treating nuclear fuel
Compositions are provided that include nuclear fuel. Methods for treating nuclear fuel are provided which can include exposing the fuel to a carbonate-peroxide solution. Methods can also include exposing the fuel to an ammonium solution. Methods for acquiring molybdenum from a uranium comprising material are provided.
US08506908B2 Electrochemical detection system
An electrochemical detection system having a disposable cartridge capable of performing a plurality of assay protocols is disclosed. The cartridge includes a blister pack for the long-term storage and controlled release of multiple reagents. The blister pack is bonded to and operatively associated with a fluidic backbone for providing the fluid pathways, storage capacity, and fluid control functions for performing multiple assay protocols. The cartridge further includes a plurality of sensors having a multiple electrode arrangement in operative association with a respective flow cell defined by the fluidic backbone. After the user has transferred a sample into the cartridge and engaged the cartridge to the reader, the reader operatively interfaces with the cartridge such that different assay protocols may be simultaneously performed in isolation from one another inside the cartridge. The reader may be one of many readers that operatively communicate data to a remote server for processing.
US08506904B2 Sample arraying/assembling device, its method, and apparatus using sample assembly
The present invention relates to a sample arraying/assembling device, its method, and an apparatus using a sample assembly, and has an object of providing a sample arraying/assembling device which is adapted to various microplates, and is capable of efficiently and quickly arraying and assembling various samples; its method; and an apparatus using a sample assembly.The present invention includes: a distributing section which is capable of holding respective solutions containing samples to be distributed, and which has a plurality of holding ends arranged in a predetermined matrix; and a wound body which has a plane surface wound with a slender foundation member on which samples are to be distributed at distribution intervals of column or line of the matrix, which is arranged in parallel at the winding intervals of the line or column on the plane surface, so that the respective holding ends can come into contact therewith.
US08506903B2 Test sensor and method for manufacturing the same
According to one embodiment of the present invention, an optical-based test sensor for use in the determination of an analyte in a liquid sample is disclosed. The test sensor includes a base, a polymer carrier, and a test membrane. The base has a capillary channel formed in a surface of the base that is adapted to move a liquid sample from an inlet to a reaction area formed in the base. The polymer carrier has a lower surface adhered to the surface of the base and is disposed over at least a portion of the capillary channel. The test membrane, which contains a reagent, is adhered to the lower surface of the polymer carrier and extends from the polymer carrier into the reaction area.
US08506891B2 Apparatus for recovering products from two reactors
An apparatus is disclosed for catalytically converting two feed streams. The feed to a first catalytic reactor may be contacted with product from a second catalytic reactor to effect heat exchange between the two streams and to transfer catalyst from the product stream to the feed stream. The feed to the second catalytic reactor may be a portion of the product from the first catalytic reactor.
US08506889B2 Device for producing dispersions and method of producing dispersions
The instant invention is a device for producing dispersions. The device for producing dispersions includes a first stator, a second stator, a shell encasing the first stator and the second stator, a rotor being disposed therebetween the first stator and the second stator thereby forming a first chamber and a second chamber, at least one first inlet port into the first chamber, and at least one outlet port out of the second chamber. The device may optionally include at least one additional second inlet port into the second chamber.
US08506883B2 Weldable oxidation resistant nickel-iron-chromium-aluminum alloy
A weldable, high temperature oxidation resistant alloy with low solidification crack sensitivity and good resistance to strain age cracking. The alloy contains by weight percent, 25% to 32% iron, 18% to 25% chromium, 3.0% to 4.5% aluminum, 0.2% to 0.6% titanium, 0.2% to 0.4% silicon, 0.2% to 0.5% manganese and the balance nickel plus impurities. The Al+Ti content should be between 3.4 and 4.2 and the Cr/Al ratio should be from about 4.5 to 8.
US08506879B2 Method for cooling hot strip
A method for cooling a hot strip conveyed on a run-out table after finishing, including ejecting rod-like flows of cooling water from nozzles to the upper surface of the steel strip such that the flows are inclined toward a traveling direction of the steel strip, and draining the cooling water using draining means disposed downstream of the nozzles.
US08506877B2 Method and device for adjusting the cooling and energy recovery of a steel strip in an annealing or galvanization phase
A method and a device adjust the cooling of a steel strip in an annealing or galvanization phase. The device is suitable for the forced cooling of a steel strip continuously running in a plant adapted for the continuous annealing or the continuous tempering galvanization. The device has at least one exchange member for transferring the heat of the steel strip to cooling water and includes an outlet for the cooling water thus heated up. At least one cooling unit is provided and has a sealed enclosure connected to the outlet of the exchange member and includes at least one outlet to a Venturi effect device such as a vapor outlet ejector and in which the cooling water itself is subjected to a vacuum-vaporization cooling. An auxiliary outlet of the sealed enclosure is connected to an inlet of the exchange member.
US08506871B2 Process of making a monocomponent non-woven web
A porous monocomponent nonwoven web contains a bimodal mass fraction/fiber size mixture of intermingled continuous microfibers and larger size fibers of the same polymeric composition. There are at least five times as many microfibers as larger size fibers, and a histogram of the mass fraction of fibers vs. fiber size exhibits a larger size fiber mode greater than 10 μm. The web may be made by flowing fiber-forming material through a die cavity having larger size orifices and at least five times as many smaller size orifices to form filaments, attenuating the filaments into fibers and collecting the attenuated fibers to form the nonwoven web. The web is especially well suited to the manufacture of self-supporting three dimensional articles such as molded cup-shaped respirators and pleated air filters.
US08506868B2 Method and articles including glass flakes in rubber
Rubber articles such as tires, hoses and lining sheets comprising glass flakes exhibit improved fluid impermeability. Methods for the manufacture of such rubber articles are disclosed.
US08506866B2 Method for producing a multilayered part
The invention relates to a method for producing a multilayered part which comprises a moulded core (5) and a flexible polyurethane skin layer (4). The core itself comprises a moulded substrate layer (1) which is made of a substrate material, in particular a thermoplastic material, having a Shore A hardness higher than 60. The flexible polyurethane skin (4) is produced by a reaction overmoulding (ROM) process wherein a polyurethane reaction mixture is moulded in a closed mould (11, 12) over at least a first area of the core surface. The moulded core (5) comprises in addition to said substrate layer (1) a softer material which is moulded onto the substrate layer (1) and/or onto which the substrate layer (1) is moulded. This moulded softer material has a Shore A hardness lower than 60 and forms a softer layer (2) between the flexible polyurethane layer (4) and the substrate layer (1) and/or a seal (3) engaging the internal wall of the mould (11, 12) during the ROM process.
US08506865B2 Composite fabric product and production process therefor
A composite fabric product comprises at least one layer of textile material and at least one layer of melted plastic material, wherein non-melting textile material is embedded in at least one of the said layers of melted plastic material, and wherein filaments or yarns located in at least one of said layers of textile material extend into said at least one layer of melted plastic material and interlace with the non-melting textile material embedded therein.
US08506857B2 Injection compression molding method of lens
An injection compression molding method of a lens is provided, where a toggle link mechanism (65) is actuated to close a molding die (50) and a movable die plate (64) is moved to a position establishing a cavity thickness of greater than a thickness of an article to be molded while the die is closed. After injecting a molten resin into the cavity, the molten resin is sealed in the cavity and the toggle link mechanism (65) is actuated to advance the movable die plate (64) toward a fixed die plate (61), the relative position of a rear die plate (62) and the movable die plate (64) is made constant at a position where extension of a tie bar (63) becomes a predetermined value, and the molten resin is cooled for a predetermined time after completion of pressurizing the resin.
US08506853B2 Composition for optical materials
The composition for optical materials includes a polymer obtained from silsesquioxanes which are represented by average composition formula (1): (R1SiO1.5)x(R2SiO1.5)y (wherein R1 is a polymerizable group, R2 is a non-polymerizable group, x is a number of 2.0 to 14.0, y is a number of 2.0 to 14.0, provided that x+y=8.0 to 16.0, and R1 groups and R2 groups may be the same or different) and include at least one cage silsesquioxane compound. This composition is suitable for use as the antireflective film in optical devices, has less film shrinkage in the curing step, has good coated surface state and excellent moisture resistance and adhesion, has small changes in the refractive index under high temperature conditions, and is capable of forming a low-refractive-index film.
US08506850B2 Conductive fine particles, anisotropic conductive element, and connection structure
The present invention provides a conductive fine particle capable of suppressing a blackening phenomenon during storage and thus providing high connection reliability; an anisotropic conductive material containing the conductive fine particle; and a connection structure.The conductive particle which has a base fine particle, and a conductive layer and a low-melting point metal layer that are formed in the stated order on the surface of the base fine particle, wherein the low-melting point metal layer has an arithmetic mean surface roughness of 50 nm or lower.
US08506847B2 Process for the preparation of crystalline lithium-, vanadium-and phosphate-comprising materials
The present invention relates to a process for the preparation of compounds of general formula (I) Lia-bM1bV2-cM2c(PO4)x (I) with M1: Na, K, Rb and/or Cs, M2: Ti, Zr, Nb, Cr, Mn, Fe, Co, Ni, Al, Mg and/or Sc, a: 1.5-4.5, b: 0-0.6, c: 0-1.98 and x: number to equalize the charge of Li and V and M1 and/or M2, if present, wherein a−b is >0, by providing an essentially aqueous mixture comprising at least one lithium-comprising compound, at least one vanadium-comprising compound in which vanadium has the oxidation state +5 and/or +4, and at least one M1-comprising compound, if present, and/or at least one M2-comprising compound, if present, and at least one reducing agent which is oxidized to at least one compound comprising at least one phosphorous atom in oxidation state +5, drying and calcining.
US08506837B2 Field-responsive fluids
A field-responsive fluid which enters a semi-solid state in the presence of an energy field is improved by use of a plurality of energy field responsive particles which form chains in response to the energy field. The particles can be (a) composite particles in which at least one field-responsive member having a first density is attached to at least one member having a second density that is lower than the first density, (b) shaped particles in which at least one field-responsive member has one or more inclusions, and (c) combinations thereof. The particles improve the field-responsive fluid by reducing density without eliminating field-responsive properties which afford utility. Further, a multi-phase base fluid including a mixture of two or more substances, at least two of which are immiscible, may be used. The multi-phase base fluid improves the field-responsive fluid because surface tension between the boundaries of the immiscible substances in conjunction with chains formed by field-responsive particles tends to stop or retard creep flow, resulting an improved dynamic or static seal.
US08506825B2 Method and apparatus for controlling the flow rate of washing solution during the washing step in a blood centrifugation bowl
A method of washing blood mixed with undesirable elements not normally found in healthy whole blood to remove the undesirable elements, the method comprising: separating the blood into components according to relative densities of the components with a rotating centrifuge bowl; providing a port through which fluid exits the bowl, the exiting fluid having a concentration of undesirable elements; flowing washing solution into the centrifuge bowl at an initial flow rate; monitoring the fluid exiting the bowl with an optical sensor having an output signal indicative of the composition of the exiting fluid; and increasing and decreasing the flow rate of the wash solution as a function of the output signal.
US08506824B1 Method for separating putrescible organic matter from inorganic grit suspended in waste water and sewage
A method for treating waste water and sewage by introducing high pressure wash water or other fluids including gas into a housing of a hydro-cyclone and creating a cyclone with an enhanced and controllable vortex for increased removal of putrescible materials. Waste water and sewage is introduced into the housing and into the cyclone vortex. By the very high centrifugal force generated, suspended inorganic grit is quickly separated from the wash water and organic matter. The water with organic matter is then discharged typically out of the top of the housing, for returning to a water treatment plant for further processing. At this time, the separated inorganic grit, as a concentrated grit liquid, is typically funneled downwardly by gravity through a bottom of the hydro-cyclone housing for waste discharge removal.
US08506822B2 Concentration of suspensions
A process of concentrating an aqueous suspension of solid particles comprising the steps of adding at least one organic polymeric flocculant to the suspension thereby forming flocculated solids in which the flocculated solids are allowed form a layer of solids and thereby forming a more concentrated suspension in which the process comprises the addition of an effective amount of an agent that is selected from the group consisting of free radical agents, oxidizing agents, enzymes and radiation, in which the agent is applied to the suspension prior to or substantially simultaneously with adding the organic polymeric flocculant and/or the organic polymeric flocculant is added to the suspension in a vessel and the agent is applied to the suspension in the same vessel. The process is particularly suitable for solids liquid separation in which the flocculated solids are allowed to settle by sedimentation in a gravity thickener.
US08506820B2 Process and apparatus for online rejuvenation of contaminated sulfolane solvent
A continuous online process for rejuvenating whole stream of contaminated lean sulfolane in an extraction system is provided. A rejuvenator is installed in the solvent circulation loop to remove the contaminants continuously to keep the solvent clean, effective and less corrosive. The rejuvenator includes a high pressure vessel with a removable cover and a round rack with vertical stainless steel tubes fitted in the high pressure vessel. A magnetic bar is placed in each stainless steel tube. A screen cylinder is installed outside the ring of stainless steel tubes. As the contaminated sulfolane is passed through the rejuvenator, the rejuvenator picks up contaminants. The rejuvenator can be dissembled to remove the contaminants periodically. The rejuvenator is simple in construction, reliable in operation, and low in operation and maintenance costs. With this rejuvenator, the extraction system operates at high efficiency and high capacity without the dreaded corrosion.
US08506817B2 Enhanced high water recovery membrane process
Disclosed is an economical process for the purification of water containing soluble and sparingly soluble inorganic compounds using single-stage or two-stage membrane processes that integrate membrane water purification with chemical precipitation softening and residual hardness and silica removal from the membrane concentrates using ion exchange resins and silica sequestering media, respectively.
US08506810B2 Process and apparatus for low-emission storage of biodegradable matter
A process and an apparatus for low-emission storage of biodegradable materials by means of aeration, without aerobic conditions materializing in the material, permits a more consistent feed of the downstream stages in the process. Aeration inhibits methanogenesis and the risk potential of an explosive gas mixture forming in the storage vessel or in the components of the system exhausting waste gas. Closed loop control of the aeration adapts the rate of aeration to the biological activity in the stored material and minimizes air input so as to minimize the loss of methanogenesis potential by aerobic conversion of the matter whilst minimizing the energy required for aeration. The process is characterized in that controlling the aeration in the storage vessel inhibits relevant methanogenesis.
US08506805B2 System and method for installing filtering membrane module to frame structure
A system and method for installing a large-sized filtering membrane module to a frame structure with easiness is disclosed, wherein the system comprises a frame structure to which the filtering membrane module is to be installed; and an installing apparatus for installing the filtering membrane module to the frame structure, wherein the installing apparatus comprises a horizontal rod parallel to an inserting direction of the filtering membrane module into the frame structure; and a moving unit movable toward the frame structure along the horizontal rod while supporting the filtering membrane module.
US08506802B1 Stackable planar adsorptive devices
Stackable planar adsorption devices include a plurality of layers of adsorptive media provided in a web format. The layers are stacked in contiguous fashion, sealed and include fluid passageways to provide a range of scalable chromatography devices suitable for large scale manufacturing applications.
US08506800B2 System for enhancing a wastewater treatment process
A system for enhancing an activated sludge process including at least one biological reactor. A weighting agent impregnation subsystem is coupled to the biological reactor for mixing biological flocs and weighting agent to impregnate the weighting agent into the biological flocs to form weighted biological flocs. A weighting agent recovery subsystem is configured to recover the weighting agent from the weighted biological flocs and reintroducing the recovered weighting agent to the weighting agent impregnation subsystem.
US08506797B2 Downstream bioprocessing device
Large-scale downstream processing of secreted recombinant proteins is provided in a single device, wherein the contents of a plurality of bioreactors are combined simultaneous to their harvesting and purification resulting in significant savings of time and the cost of manufacturing.
US08506795B2 Process for fluid catalytic cracking
One exemplary embodiment can be a process for fluid catalytic cracking. The process may include providing a torch oil to a stripping section of a first reaction zone, which in turn can communicate at least a partially spent catalyst to a regeneration zone for providing additional heat duty to the regeneration zone.
US08506794B2 Systems, methods, and catalysts for producing a crude product
Contact of a crude feed with two or more catalysts produces a total product that include a crude product. The crude feed has a total acid number of at least 0.1. The crude product is a liquid mixture at 25 ° C. and 0.101 MPa. The crude product has a total acid number of at most 90% of the total acid number of the crude feed. One or more other properties of the crude product may be changed by at least 10% relative to the respective properties of the crude feed.
US08506791B2 Linear guide
A linear guide, in particular for a device for electrochemical metal machining, that guides a linear movement of a quill that is moved periodically in a machine frame in order to periodically modify a working gap between a cathode situated on the quill and a workpiece in the direction of the longitudinal axis of the quill, the quill being connected to the machine frame by a plurality of connecting rods, the connecting rods being situated, in the no-load, non-deflected state, essentially parallel to the longitudinal axis of the quill, and the connecting rods having at the point of connection to the quill, as well as at the point of connection to the machine frame, a notch hinge in order to enable, via the hinge, the periodic linear movement of the quill, and the flexibilities of these notch hinges being based on elasticities in their structures formed by targeted thinning of the material.
US08506785B2 Analysis apparatus with renewable electrode contact tip
An analysis apparatus enables a plurality of analysis processes to be accurately and efficiently performed. The analysis apparatus includes a detention tank in which a specimen is stored, and a voltage applier. The voltage applier includes a power source and a contact tip to be brought into contact with the specimen for applying a voltage necessary for analyzing the specimen. The voltage applier renews the contact tip from a used state to an unused state after completing an analysis and before starting the subsequent analysis.
US08506781B2 Hydrolysis-resistant polyacrylamide gels
Polyacrylamide gels that offer high resolution in protein separations and are more stable relative to hydrolysis than conventional polyacrylamide gels that rely on Tris or Tris-Bis as buffering agents are made by incorporating triethanolamine in place of most or all of the Tris or Tris-Bis.
US08506778B2 Diagnostic devices incorporating fluidics and methods of manufacture
The present invention relates to diagnostic devices incorporating electrode modules and fluidics for performing chemical analyses. The invented devices consist of a sensor array formed on an electrode module, the sensor array being contained within a fluidic housing. The electrode module is a laminate of a perforated epoxy foil and a photo-formed metal foil with sensor membranes deposited into the perforations. The fluidic housing is an element consisting of a plastic card-like body with fluidic conduits and a sealed fluid reservoir contained in a foil-lined cavity.
US08506774B2 Vacuum processing device
To provide a vacuum processing apparatus applicable to various manufacturing processes, by efficiently and highly reliably stacking films of various types and thicknesses and by downsizing the manufacturing apparatus by suppressing size increase of the apparatus due to increase of the number of film forming chambers caused by increase and complexity of process steps. A vacuum processing apparatus is provided with a plurality of film forming process parts which are provided with rotating transfer tables and film forming chambers. The rotating transfer tables form a transfer path for a work to be processed, in chambers which can be vacuum-exhausted. The film forming chambers are provided for depositing a film on the work to be processed which is arranged and transferred along a circumference which has a rotating shaft of the rotating transfer table as a center. The vacuum processing apparatus is also provided with a connecting part which connects the film forming process parts so as to share a vacuum space between the chambers, and the work to be processed in the film forming process parts is mutually transferred in the vacuum. A load lock mechanism is provided in one of the film forming process part or in the connecting part.
US08506773B2 Drive end-block for a rotatable magnetron
A drive end block for a magnetron arrangement with a rotating target, comprises an end block housing having a rotatably mounted drive shaft. The drive shaft is arranged in the end block housing, accessible at an end from outside of the end block housing for connection to the rotating target, and adapted at its end inside the end block housing for introduction of a torque. An electric motor with a stator and a rotor for creating the torque is arranged inside the end block housing.
US08506770B2 Electrochemical planarization system comprising enhanced electrolyte flow
A polishing pad for an electrochemical planarization tool comprises a patterned surface that forms appropriate electrolyte flow channels for directing an electrolyte from the center to the periphery thereof. Consequently, a continuous electrolyte flow may be established, thereby significantly reducing the accumulation of contaminants in the polishing pad, thereby contributing to enhanced process uniformity so that frequent rinsing of the polishing pad and replacement of the electrolyte solution may be avoided.
US08506765B2 Device and method for thermal decomposition of organic materials
An apparatus for thermally decomposing organic feedstock material utilizing a series of connected vessels. Each of the vessels is provided with an inlet and an outlet for transferring the organic feedstock material between the vessels. Separate heat exchangers are located between the inlet and outlet of each vessel. A catalyst material, such as a permeable mesh, is included between the inlet and outlet of each vessel to accelerate liquefaction of gaseous hydrocarbons.
US08506764B2 Water condenser
A water condenser comprising a primary entry access, and an air entry access so as to bring air inside. A junction between a condensate reservoir passageway and a main passageway to control air flow. The condensate reservoir passageway leads to a condensate reservoir; the main passageway provides access to condensation chambers. A boiler located in the center of the water condenser below the first and second condensation chambers heats up humid air which rises as steam into the first and second condensation chambers where it condenses on the cold surfaces of the walls and ceiling.
US08506763B2 Device for heating a liquid comprising a solvent and solute, and separating the solvent and solution
A device for treating a liquid comprising a solvent and a solute, and separating the solvent and solute, the device comprising a continuous flow treatment chamber including: (a) one or more drying zones; (b) one or more return zones to circulate heating fluid continuously through drying zone(s) and return zone(s) sequentially; (c) a heating fluid inlet(s) in at least one of the return zones for the introduction of the heating fluid; (d) a circulating fan to circulate the heating fluid; (e) a liquid inlet(s) in the drying zone(s) including nozzles though which liquid to be treated is introduced in misted form into the zones; (f) a solute collector(s) located in the drying zone(s) downstream of the liquid inlet(s); wherein the introduced liquid is heated by the heating fluid and the solute is separated from the liquid in the solute collector(s).
US08506760B2 Coking plant comprising two oven chamber rows arranged in parallel
A coking plant first and second longitudinally extending rows of oven chambers all of generally the same width and generally the same longitudinal spacing and together defining a corridor into which the chambers all open. The first and second rows are longitudinally offset from each other by a predetermined distance that is greater than the oven-chamber width A device for servicing the oven chambers and movable longitudinally in the corridor between the two rows of oven chambers has first and second service machines transversely facing the respective first and second rows and operable to service the chambers thereof. A coupling of variable longitudinal length between the first and second machines operable can vary the longitudinal spacing between the two machines.
US08506759B2 Belt having semicontinuous patterns and nodes
A macroscopically monoplanar secondary belt for manufacturing a cellulosic fibrous structure is provided. The belt, having two mutually orthogonal principal directions, a machine direction and a cross machine direction, and having a reinforcing structure; and a framework of protuberances joined to said reinforcing structure and extending outwardly therefrom to define deflection conduits between the protuberances, the framework of protuberances having a semicontinuous pattern and the deflection conduits having a semicontinuous pattern, is further provided. The protuberances and the deflection conduits have a vector component extending substantially throughout one principal direction of the belt, each protuberance of the pattern being spaced apart from an adjacent protuberance in the pattern. The protuberances have primary protuberances having a first width, T and the nodes have a second width, N, wherein a ratio of N to T is from about 1.5 to about 5.
US08506758B2 System for guiding web patching using a re-reeler
A method for guiding web patching, using a re-reeler, in connection with a paper machine and an off-line coating machine, in which method a defect map of the web is created on the paper machine, to show deviations some of which are shown on the coating machine, using selected criteria, to the operator, the deviations being patched using the re-reeler, guided by the defect map and preset patching rules. On the coating machine, the virtual location of the selected deviations is monitored through the coating machine and if a possible web break occurs, a deviation is localized relative to the web break, and on the basis of this monitoring, feedback is provided to the patching rules of the re-reeler, in order to optimize them.
US08506757B2 Hydrophobically modified poly(aminoamides)
Disclosed herein are hydrophobically-modified poly(aminoamides) useful as fixative detackifiers for stickies and pitch control in papermaking processes. These polymers are prepared via modification of amine-containing water-soluble poly(aminoamides) with reactive functional group-containing hydrophobic compounds. In particular, poly(aminoamides) may be modified, under appropriate reaction conditions, with long chain alkyl glycidyl ether, AKD (alkyl ketene dimer), ASA (alkyl succinyl anhydride), or Quab (3-chloro-2-hydroxypropyl-N,N,N-dimethylalkyl ammonium chloride). These novel polymers are effective in inhibiting deposition of organic contaminants in pulp and papermaking systems.
US08506748B2 Imaging process for flooring material
A method is provided for imaging vinyl flooring material. Images are formed on vinyl flooring material having enhanced thermomechanical properties using heat activated imaging methods. Minimum shrinkage of the flooring substrate and minimum image deformation are provided by the invention.
US08506743B2 Composite sandwich structure with integrated reinforcement area and method of producing the same
Producing a local reinforcement in a core structure of a composite sandwich structure involves forming a hole in a cover layer and the core of the sandwich structure, forming a hollow space in the core with a diameter the same as or preferably larger than that of the hole, introducing a spatial bounding device through the hole into the hollow space, seating the spatial bounding device in the hollow space to contact outwardly against parts of the core preferably by outwardly expanding the device, and introducing a filler material into the spatial bounding device. A sandwich structure includes a core between cover layers, and a local reinforcement including a hole in at least one of the cover layers, a space in the core with a larger diameter than the hole, a spiral sleeve in the space, and a filler material inside the spiral sleeve.
US08506742B2 Method for laminating plastic films with wood-base substrates, in particular for producing high-gloss surfaces
The invention relates to a method for laminating a plastic film with a wood-base substrate, in particular for producing a high-gloss surface on a wood-base substrate, in which a plastic film is laminated by means of a laminating agent, preferably an adhesive, with a wood-base substrate and permanently bonded to the wood-base substrate, the plastic film being formed so as to be transparent on its top, and the products obtainable in this manner and their use, in particular in the area of the wood and furniture industry, for example for the production of pieces of furniture and fitments of all kinds.
US08506740B2 Manufacturing electrochemical sensor module
Certain processes for manufacturing an electrochemical sensor module include molding first and second opposing portions of a sensor module housing onto a carrier; installing an electrode arrangement on the first portion of the sensor module housing; folding the carrier to align the first portion of the sensor module housing with the second portion; and joining the first and second portions of the sensor module housing. The carrier can be advanced amongst different stations that perform the various process steps.
US08506739B2 Method of producing sails using reinforced, formed fabrics
The present disclosure relates to methods and compositions useful for the manufacture of sails. Particularly, the present disclosure relates to shaped, reinforced fabrics that can be used to make high-performance, shaped, reinforced sails.
US08506737B2 Method of making coated glass article, and intermediate product used in same
A method of making an insulating glass (IG) window unit includes: having a coated article including a multi-layered low-E coating on a glass substrate; at least two flexible protective sheets adhered to a top surface of the low-E coating via at least an adhesive layer, and a protective coating over the low-E coating and/or over at least one of the flexible protective sheets in order to substantially fill one or more gaps formed between the low-E coating and the flexible protective sheet(s) and/or between the flexible protective sheets; and following cutting, edge seaming, and/or washing, removing at least part of the temporary protective coating by peeling the protective sheets off and removing at least part of the protective coating when peeling off the protective sheets.
US08506736B1 Core joiner and cutter apparatus
An automatic core joiner and cutter apparatus for use in the recycling of used cores and the manufacture of new conjoined cores is disclosed. The apparatus combines an infeed unit, a milling unit, and an outfeed unit, all controlled by a PC. The used core is milled by the infeed milling bit and the core remnant is milled by the outfeed milling bit. A glue applicator applies glue to at least one of the milled surfaces and the milled surfaces are mated together to produce a new conjoined core. The infeed cutting and milling operations and the outfeed cutting and milling operations are controlled by the controller and performed at the same time.
US08506735B2 Pre-applied protective jacketing construction for pipe and block insulation
A protective jacketing-insulation composite structure and method is provided for inhibiting the corrosion of a pipeline. The method includes forming a porous-insulation into an elongated-arcuate-shape, applying a sodium silicate solution layer to the insulation and at least partially within the pores thereof, permitting the sodium silicate solution layer to set to a threshold amount, adhering an outer facing to the sodium silicate solution layer after the permitting step is accomplished, installing the insulation and facing to the outer surface of a pipeline, and sealing any exposed edges or seams that may exist between multiple installed products. A structure such as made from this method can have a release layer and contact adhesive.
US08506732B2 Heat treatment of helical springs or similarly shaped articles by electric resistance heating
Apparatus and method are provided for metallurgical heat treatment of coil springs, or similarly shaped workpieces and articles of manufacture, by electric resistance heating along the entire length of the workpiece so that the ends of the workpiece can be heat treated to the same degree and quality as the section of the workpiece between its two ends.
US08506727B2 Piston rings
The invention relates to a steel material composition, in particular for producing piston rings and cylinder sleeves, containing the following elements in the given fractions in relation to 100% by weight of the steel material: 0.5-1.2% by weight C, 2.0-20.0% by weight Cr, 49.0-97.1% by weight Fe, 0.1-3.0% by weight Mn, 0.1-3.0% by weight Mo, 0.-7.0% by weight Nb, 2.0-10.0% by weight Si, 0-7.0% by weight Ti, 0.-7.0% by weight V and 0.-0.5% by weight W, the sum of the fractions of Nb, Ti, V and W being 2.0-7.0% by weight. Said composition can be produced by melting the starting materials and casting the melt in a pre-fabricated mold.
US08506722B2 Method for cleaning filtering membrane
A method for cleaning a filtering membrane, contaminated by contaminants including inorganic and organic materials during a fluid-filtering process, is disclosed, the method comprises cleaning the filtering membrane by using a first cleaning solution of pH 6˜9 so as to remove the organic material from the filtering membrane; and cleaning the filtering membrane by using a second acid cleaning solution so as to remove the inorganic material from the filtering membrane, wherein the cleaning method of the present invention uses the first cleaning solution having pH 6˜9 instead of a strong-alkaline cleaning solution so as to prevent the filtering membrane from being damaged, and also uses the cleaning solution maintained at a relatively low temperature instead of hot water so as to improve economical efficiency by reduction of energy consumption.
US08506721B2 Dish washer and controlling method thereof
A method of controlling a dish washer includes performing a wash cycle for washing dishes with wash liquid and performing a rinse cycle for rinsing the washed dishes. Cold water is supplied to a sump after completion of the rinse cycle, the cold water lowering the temperature with a tub. After completion of supplying the cold water, a drying cycle for drying an inside of the tub is performed.
US08506720B2 Wash rack system with side trough
A cleaning system is provided which includes a wash floor, a side trough adjacent the wash floor, which is positioned to receive waste from the wash floor and is attached to a filtering system. A method of using this cleaning system is also provided.
US08506719B2 Robotic submersible cleaning system
A cleaning system includes a chassis supporting a propulsion system for propelling the cleaning system across a surface. At least one sensor of a first type is coupled to the chassis, and a surface engagement mechanism is configured to maintain the cleaning system coupled to the surface as the propulsion system propels the cleaning system across the surface. A cleaning device is coupled to the chassis and configured to abrade the fouling from the surface, and a controller coupled to the chassis and in signal communication with the propulsion system and the first sensor. The controller is configured to receive a signal from the at least one sensor of the first type and control the propulsion system in response to the signal.
US08506717B2 Methods of treating a biomass for enzymatic hydrolysis
The present invention is a process for treating a feedstock comprising holocellulose. The process comprises mixing the feedstock with a solution comprising cellulose binding domains to form a mixture. The mixture is then subjected to conditions sufficient to reduce the crystallinity of holocellulose. Subsequent enzymatic hydrolysis may show an improved rate and/or fermentable sugar yield as compared to processes which do not employ the process.
US08506715B2 Coating deposition apparatus and method therefor
A coating deposition apparatus includes a plurality of mounts that are adapted to mount work pieces at respective work piece locations. A crucible is located adjacent the plurality of mounts for emitting a source coating material. A plurality of gas nozzles are respectively directed at the work piece locations to scatter the emitted source coating material at surfaces of the work pieces that are otherwise difficult to coat.
US08506714B2 Substrate processing system
Disclosed is a substrate processing system, including: a processing chamber to process a substrate; a vaporizing unit to vaporize a material of liquid; a supply system to supply the processing chamber with gas of the material vaporized by the vaporizing unit; an exhaust system to exhaust an atmosphere in the processing chamber; and a cleaning liquid supply system to supply the vaporizing unit with cleaning liquid for cleaning a product deposited in the vaporizing unit, wherein the cleaning liquid supply system supplies at least two kinds of cleaning liquids into the vaporizing unit so that the product can be removed from the vaporizing unit by action of the two kinds of cleaning liquids on the product.
US08506713B2 Film deposition apparatus and film deposition method
The present invention is a film deposition apparatus configured to deposit a film on a substrate that has been loaded into a vacuum container via a transfer opening and placed on a table in the vacuum container, by supplying a process gas to the substrate from a process-gas supply part opposed to the table under a vacuum atmosphere, while heating a table surface of the table, the film deposition apparatus comprising: an elevating mechanism configured to vertically move the table between a process position at which the substrate is subjected to a film deposition process, and a transfer position at which the substrate is transferred to and from an external transfer mechanism that has entered from the transfer opening; a surrounding part configured to surround the table with a gap therebetween, when the table is located at the process position, so that the surrounding part and the table divide an inside of the vacuum container into an upper space, which is located above the table, and a lower space, which is located below the table; a vacuum exhaust conduit in communication with the upper space, through which a process atmosphere in the upper space is discharged to create a vacuum in the upper space; a heating unit configured to heat a gas contact region ranging from the upper space to the vacuum exhaust conduit, to a temperature higher than a temperature allowing adhesion of reactant; and a heat insulation part disposed between the heating unit and a lower part of the vacuum container surrounding the lower space.
US08506705B2 Method for manufacturing nitride single crystal
A nitride single crystal is produced on a seed crystal substrate 5 in a melt containing a flux and a raw material of the single crystal in a growing vessel 1. The melt 2 in the growing vessel 1 has temperature gradient in a horizontal direction. In growing a nitride single crystal by flux method, adhesion of inferior crystals onto the single crystal is prevented and the film thickness of the single crystal is made constant.
US08506702B2 Manufacturing method of lightweight construction materials using sludge waste
The present invention relates to a manufacturing method of manufacturing lightweight construction materials using sludge waste, more specifically to a manufacturing method of manufacturing lightweight construction materials using the sludge waste which is manufactured by adding feldspar, bentonite, zeolite, loess, mica and agalmatolite to sludge waste and the lightweight construction materials manufactured thereby. According to the present invention, lightweight construction materials can be manufactured which are environmentally friendly by recycling waste sludge, can reduce energy consumption by simplifying the processes, and have superior strength and water permeability by mixing specific inorganic materials.
US08506699B2 Thermoreversibly crosslinked elastic bituminous composition
The disclosure relates to a bituminous composition comprising at least one bitumen and at least one organogelling molecule taken alone or as a mixture, said organogelling molecule being represented by the following general formula (I): where: A represents an acyclic, cyclic or polycyclic, saturated or unsaturated, linear or branched hydrocarbon-based group having 3 to 92 carbon atoms, resulting from the polymerization of the side chains of at least one unsaturated fatty acid, X represents an NH group or an oxygen atom O, R1 represents a group chosen from: a linear or branched hydrocarbon-based group having 2 to 40 carbon atoms, optionally comprising one or more heteroatoms and optionally comprising one or more unsaturations, or a substituted or unsubstituted aromatic group, R2 represents a group chosen from: a hydrogen atom, a linear or branched hydrocarbon-based group having 1 to 40 carbon atoms, comprising one or more heteroatoms and optionally comprising one or more unsaturations, or a substituted or unsubstituted aromatic group, m and n represent, independently of one another, an integer that varies from 1 to 4, p represents an integer that varies from 0 to 4, q represents an integer that varies from 1 to 4 or a combination of these values, Y represents a group comprising a hydrogen bond donor such as the NH group and a hydrogen bond acceptor such as the C═O group.
US08506698B2 Oral compositions and methods
An oral composition comprising an active component and an adhesive film forming component comprising bleached shellac and shellac wax for the treatment of teeth.
US08506694B2 Phase separation ink
A phase separation ink including at least one crystallizable component that crystallizes as it cools from a first ink jetting temperature to a second lower temperature; at least one amorphous component comprising a material that remains amorphous at the second temperature; an optional colorant; wherein the at least one crystallizable component and the at least one amorphous component are in a molten, single phase state at the first ink jetting temperature; wherein at the second temperature, the phase separation ink comprises a crystalline phase comprising the at least one crystallizable component and an amorphous phase comprising the at least one amorphous component; wherein the amorphous phase of the at least one phase separation ink substantially penetrates into the final image receiving substrate and the crystalline phase of the at least one phase separation ink substantially remains on the surface of the final image receiving substrate.
US08506693B2 CO2 recovery system and CO2 recovery method
A CO2 recovery system includes an absorber 2 and a regenerator 3. The absorber 2 includes a CO2 absorbing section 21 and at least one water-washing section 22. The CO2 absorbing section 21 allows flue gas 101 to come into contact with a basic amine compound absorbent 103 so that the basic amine compound absorbent 103 absorbs CO2 in the flue gas 101. The at least one water-washing section 22 allows the decarbonated flue gas 101A in which the amount of CO2 has been reduced in the CO2 absorbing section 21 to come into contact with wash water 104A and 104B to reduce the amounts of the basic amine compounds entrained in the decarbonated flue gas 101A. The regenerator 3 releases the CO2 from the basic amine compound absorbent 103 containing CO2 absorbed therein.
US08506686B2 Reel-to-reel bioforensic aerosol collection and storage system
A reel-to-reel aerosol collection and storage system for capturing and storing a plurality of separate samples of aerosol particles using electrostatic precipitation technology for collecting such particles onto a tape mechanism for analysis at a future time. The particles are collected onto a region of the collection tape for a defined period of time and then that portion of the collection tape is advanced out of the collection zone and manipulated so as to form sealed pouches or pockets which can be either severed from the collection tape for individual storage in a temperature controlled storage container, or which can be stored on a take-up reel in a temperature controlled environment. The collected aerosol particles are stored with a buffer fluid to preserve and maintain the viability of the collected particles for future extraction and analysis. Several embodiments for forming sealed pouches or pockets and methods of storing the collected particles are disclosed.
US08506682B2 Process for purification of monosilane
Provided is a method of purifying monosilane. More particularly, the method includes removing impurities from a crude material containing monosilane and ethylene by fractional distillation (operation 1), and removing ethylene and residual impurities by passing the crude material purified in operation 1 through activated carbon (operation 2). According to the method, high-purity monosilane may be more simply and effectively obtained without additional production of byproducts by selectively adsorbing ethylene, which is difficult to separate by fractional distillation, using an activated carbon.
US08506681B2 Apparatus, system and method for cleaning air
An apparatus for cleaning air includes a housing having a chamber. The scrubber includes a carbon dioxide scrubber layer disposed in the chamber which claims carbon dioxide from air passing through the scrubber layer. The scrubber includes a forcing element which draws the air into the scrubber and forces the air through the scrubber layer which is powered without any electricity. A system for supporting a breathable environment for users. The system includes an enclosure. The system includes an air scrubber disposed in the enclosure which cleans carbon dioxide from air in the enclosure that is powered without any electricity. A method for cleaning carbon dioxide from air. The method includes the steps of flowing compressed air through a fluid driven motor to operate the motor without any electricity. There is the step of rotating a fan with the operating motor. There is the step of drawing air into a chamber of a housing with the fan blowing the air through a carbon dioxide scrubber layer of soda lime in the chamber, which scrubs the air of carbon dioxide, and out through an opening in the chamber above the layer. A cartridge for a scrubber.
US08506677B2 Membranes and reactors for CO2 separation
The present disclosure relates to a system for carbon dioxide separation. The system includes a conducting membrane having two phases. The first phase is a solid oxide porous substrate. The second phase is molten carbonate. The second phase is positioned within the solid oxide porous substrate of the first phase. The system also includes a H2 and CO2 gas input stream separated from a CH4 gas input stream by the conducting membrane. The CO2 is removed from the H2 and CO2 gas input stream as it contacts the membrane resulting in a H2 gas output stream from the H2 and CO2 gas input stream and a CO and H2 gas output stream from the CH4 gas input stream.
US08506674B1 Automated dust filter cleaning
A method of cleaning a dust filter includes applying a negative electrical potential to a first electrode in a first area of a dust filter and applying a positive electrical potential to a second electrode disposed in a second area of the dust filter, wherein a voltage differential between the first and second electrodes is sufficient to cause electrostatic movement of dust from the first area to the second area. Then, the method further includes applying a negative electrical potential to the second electrode and applying a positive electrical potential to a third electrode disposed in a third area of the dust filter, wherein a voltage differential between the second and third electrodes is sufficient to cause electrostatic movement of dust from the second area to the third area, and wherein the first, second and third areas are generally linearly arranged.
US08506672B2 Method of coal gasification and direct ironmaking and system therefor
A system of coal gasification and direct ironmaking attains both heat recovery in a coal-based direct ironmaking process and a reduction in equipment investment in a coal gasification process. A waste heat boiler in the system recovers heat of gas exhausted from a coal gasification furnace. A heater in exhaust gas lines of a heat reduction furnace in the coal-based direct ironmaking process superheats the steam generated by and exhausted from the waste heat boiler. A superheated steam line supplies the steam superheated by the heater as an oxidant to the coal gasification furnace.
US08506667B2 Filters and methods for imparting structural support to pleated filter media
Certain embodiments of the invention may include filters and methods for imparting structural support to a pleated filter material. According to an example embodiment, the method includes forming a filter structure from one or more sections of pleated filter media, wherein the filter structure comprises one or more filter pleats. The method also includes extruding a banding material to form one or more radial support regions in at least circumferential contact with at least one of an inner or an outer surface of the filter structure, and maintaining spacing between the one or more filter pleats of the filter structure with the one or more radial support regions.
US08506665B2 Centrifugal separator assembly
A centrifugal separator assembly including a polygonal separator chamber formed of planar wall sections joined with each other to provide a substantially gas tight structure and having at least four pairs of planar opposite wall sections. The chamber includes a tapered portion formed by having a first inward bending in each of the wall sections. The tapered portion extends as a discharge channel for separated particles from the separator chamber, which discharge channel is formed of first and second pairs of opposite wall sections being perpendicular to each other. In the discharge channel for separated particles, the first pair of wall sections extends into the area between the second pair of wall sections.
US08506661B2 Polishing slurry for copper films
A slurry for use in a chemical mechanical planarization process for a wafer comprises a chemical portion and a mechanical portion. The chemical portion comprises a surfactant that forms a layer over a metallic layer of the wafer to decreasing dishing to less than an average of 843 Å reduce the static etch rate of the metallic layer. The mechanical portion comprises an abrasive agent to assist in the planarization of the metallic layer of the wafer. In another embodiment, a slurry for polishing a copper layer formed over a first layer is disclosed. The slurry comprises an abrasive agent; and a surfactant comprising at least one non-ionic surfactant to reduce the static etch rate of the copper layer. The shelf life of the slurry exceeds 90 days.
US08506659B2 Hydrogen generating apparatus
A hydrogen generating apparatus includes a chemical reaction chamber, a chemical solution reservoir, and an unpowered pressure producing member for moving a chemical solution from the chemical solution reservoir to the chemical reaction chamber.
US08506658B2 Production of renewable bio-distillate
A process and system for separating a light fraction, a bio-distillate fraction, and a heavy fraction from a bio-oil, and for producing a renewable distillate including at least in part the bio-distillate fraction and a stabilizing additive, is provided. The process comprises separating bio-oil into light, bio-distillate, and heavy fractions based on their boiling points. At least a portion of the bio-distillate fraction and a stabilizing additive are blended with a petroleum-derived-diesel-range stream, without any prior hydrotreatment, to thereby provide a renewable distillate composition.
US08506652B2 Disperse dyes
The present invention is directed to a disperse dye of formula (1) Wherein, X, Y and Z are, independently, hydrogen, halogen, cyano, nitro or SO2F; Wherein at least one of X, Y and Z is SO2F. R1 is hydrogen, methyl, hydroxyl or NHR4; R2 is hydrogen, chloro or methoxy; R3 is hydrogen, (C1-C4)-alkyl or —CH2(CH2)nCOOCH2CN; R5 is hydrogen, (C1-C4)-alkyl or —CH2(CH2)mCOOCH2CN; R4 is —COCH3, —CO C2H5, —SO2CH3 or SO2C2H5; n and m are independently 0,1 or 2, with the proviso: —When, Y and Z both are Cl, R1 is other than methyl. When, R2 is Hydrogen and R3, R4 both are alkyl, R1 is selected from NHSO2CH3 or NHSO2C2H5. Disperse dyes of Formula (I) have excellent washing fastness and light fastness on polyester fiber and polyester blends.
US08506647B2 System for maintaining body canal patency
A device is provided for insertion and implantation in a patient's bodily canals or vessels such as the ureter. The device includes interconnected loops that form a flexible structure that may span the length of a bodily canal. The device may include retaining elements at both or either ends. Further according to the present invention, there is provided a stylet for delivering the device to the desired body canal. The device minimizes contact with the lining of the bodily canal while retaining the patency of the canal. The device also is adjustable in length and shape. It is particularly useful for maintaining the tortousness of a body canal.
US08506644B1 Acetabular prosthesis to be fixed without cement
The invention relates to an acetabular prosthesis comprising an, in general, hemispherically shaped insert (1) having a crown (5) and an apex (4), this insert being provided, on its outer surface (2), with at least one fin. The invention is characterized in that the fin (6) has a face (9) starting from the crown (5) of the insert (1) and extending toward the apex (4) of the insert while forming a crest (10). This crest (10) has an, in particular, curved shape.
US08506643B2 Acetabular prosthesis system
An acetabular prosthesis system configured to be coupled to a surgically-prepared acetabulum includes an acetabular shell, an augment component, and a fastener configured to couple the acetabular shell and the augment component together.
US08506642B1 Hip implant with porous body
A hip implant having two distinct bodies, a neck body and a bone fixation body. The neck body is formed from a solid metal and has an interface for connecting to a femoral ball. The bone fixation body has an elongated shape and is formed as a porous structure that is inserted into an intramedullary canal of a patient.
US08506641B2 Arthrodesis implant for finger joints and related methods
An arthrodesis implant is for a finger joint of a hand of a patient. The arthrodesis implant may include an extramedullary proximal anchor including a first member having a fastener-receiving passageway therethrough to receive a fastener to anchor the first member to an extramedullary portion of a proximal bone of the finger joint of the hand of the patient. The arthrodesis implant may also include an intramedullary distal anchor having a second member for being anchored within an intramedullary portion of a distal bone of the finger joint of the hand of the patient, and a coupling for securing the first and second members together.
US08506638B2 Shoulder prosthesis
A prosthesis is provided and may include a central body having a longitudinal axis and a plurality of arms extending from the central body in a direction substantially perpendicular to the longitudinal axis. The plurality of arms may each include a first planar surface, a second planar surface, and a third planar surface that are each formed at an obtuse angle relative to one another to define an outer shape of the prosthesis.
US08506634B2 Intervertebral implant
In an intervertebral implant, having an upper part that has a support face for a vertebra and a lower part that has a support face for an adjacent vertebra, on each of which parts engagement elements, which are accessible from one side of the intervertebral implant, for a manipulation instrument are disposed, in order to minimize the structural height of the intervertebral implant upon insertion into an intervertebral space, it is proposed that the upper part and lower part each have protrusions and recesses aimed at the respectively other part, which are offset laterally from one another in such a way that when the upper part has been brought close to the lower part they mesh with one another; and that the engagement elements on the upper part and on the lower part are each disposed in protrusions of these parts in such a way that the engagement elements of the upper part and lower part are located side by side and at least partly overlap in the direction of the height of the intervertebral implant.
US08506629B2 Implant for transforaminal interbody fusion
The invention relates to an implant for the transforaminal intracorporeal fusion of lumbar vertebral column segments. At least some sections of the surface areas that are in direct contact with the spinal column are provided with an anti-dislocation mechanism (1) while an attachment part (4) for a positioning instrument (10) is provided in or on the implant and holes (6) or hollow spaces are disposed in the implant for filling purposes. According to one embodiment of the invention, the attachment part is configured as a revolute joint. In a further embodiment, the implant member has the shape of a sickle, the curvature of which is oriented ventrally and the interior of which is oriented dorsally. The attachment part is located at one end of the sickle while the opposite end of the sickle has a beak-type, tapering shape (5). At least one filling hole is provided between the sickle walls.
US08506628B2 Ossicular prosthesis having helical coil
An ossicular prosthesis includes a proximal end provided with an open conically helical coil for engaging a first ossicular structure, and a distal bell head, piston, or shoe for engaging a second ossicular structure. A connecting element extends therebetween the two to hold the helical coil structure which engages the second ossicular engagement structure in a preferably fixed relationship. The helical coil defines a plurality of spaced apart adjacent windings, with open spaces between the windings. Each adjacent winding decreases in diameter from the proximal to distal end. The windings of the coil may be adjusted relative to each other in length or angle to fit the anatomy. In accord with a one method of use, the helical coil and optionally other portions of the prosthesis function as an armature or endoskeleton. A cement may be provided over the prosthesis to reconstruct the eroded or missing ossicles.
US08506622B2 Mobile external coupling for branch vessel connection
An endovascular prosthesis includes a tubular body and a flexible springy mobile external coupling. The tubular body includes a graft material and stents coupled thereto with a forms a lumen therethrough. The mobile external coupling extends outwardly from the tubular body. The mobile external coupling includes a graft material and is generally frustoconically shaped. The mobile external coupling includes a base coupled to the tubular body, a top spaced from the tubular body, and a coupling lumen disposed between the base and the top, wherein the coupling lumen is in flow communication with the body lumen. A helically shaped stent may be coupled to the coupling graft material to make it flexible and springy.
US08506621B2 Flow-deflecting medical device
The disclosure relates to a flow-deflecting medical device comprising a support structure and two flow-deflecting members attached to the support structure. The first flow-deflecting member is movable to a position in which it contacts and substantially seals against the second flow-deflecting member.
US08506618B2 Multi-section filamentary endoluminal stent
A multi-section filamentary stent comprises a braided section, which is a cylindrical mesh of a first set of filaments, connected to at least one wound section comprising a second set of one or more filaments having a repeating configuration with a bent portion. The two sections are preferably connected by at least one continuous filament extending into both sections. The stent may comprise a first section, having a braided first stent architecture with a first flexibility and a first radial force, and a second section, having a non-braided second stent architecture with a second flexibility less than the first flexibility and a second radial force greater than the first radial force, in which at least one continuous filament is integral to both the first and second sections.
US08506608B2 Orthopedic fixation device with bioresorbable layer
An orthopedic screw is used in a fixation device for treating fractures. The device has a body with holes to accept the bone screws. The bone screws have a layer of bioresorbable material on the shaft. Engagement between the bone screws and the body is initially through the bioresorbable material, which engagement rigidly fixes the relative angular orientation between the bone screws and the body when the device is applied to a bone. As the bioresrobable material is resorbed the angular relation between the bone screws and the body is no longer rigidly fixed, thereby effecting a transformation from rigid osteosynthesis to flexible osteosynthesis to allow micromotion between the bone fragments which promotes healing.
US08506607B2 Orthopedic screw fastener system
An orthopedic screw fastener system, includes at least one screw, consisting in each case of a screw head and of a screw shank, the screw head being provided with a thread, and at least one plate with a thickness, provided with at least one through-bore which is able to receive a screw. The plate has a through-opening, formed by at least two through-bores, each through-bore being defined by a midpoint and by a radius, and the through-bores are offset relative to each other and intersect each other in such a way that intersection lines and/or intersection surfaces form, which extend into the depth of the through-opening.
US08506601B2 Low profile dual locking fixation system and offset anchor member
A coupling device for securing an elongate member to the spine is provided. The coupling device comprises a compressible inner member that secures an anchor member therein when the inner member is axially shifted within an outer member. The elongate member is retained within the device by an axially inserted locking member, and may be secured independently of the anchor member. The coupling device and anchor may be configured to provide increased angulation of the anchor with respect to the coupling device. For instance, anchor member may have an offset head portion in order to provide normal pivoting of the coupling device when the anchor is attached to bone at an angle.
US08506600B2 Methods for stabilizing bone using spinal fixation devices
A method of stabilizing bone, such as a spine, includes providing a coupling element having first and second sections that are angled relative to one another, the coupling element having rod receiving openings for securing an elongated member such as an orthopedic rod, and assembling the coupling element with an anchoring element. The method includes securing the anchoring element in bone, moving the coupling element relative to the anchoring element to align the rod receiving openings with the orthopedic rod, securing the orthopedic rod in the rod receiving openings, and after the securing step, locking the coupling element from further movement relative to the anchoring element.
US08506588B2 Suture retriever-sheath dilator tool and method for use thereof
A tool serves to facilitate one or more of dilation of a flexor tendon sheath and corresponding pulleys, attachment of a severed flexor tendon thereto, passage of the severed flexor tendon through the flexor tendon sheath and the corresponding pulleys, and reattachment of the severed flexor tendon. The tool includes a tip portion, a shaft portion, and a handle portion. During use of the tool, the tip portion and at least a part of the shaft portion can be passed through the flexor tendon sheath, and the handle portion is can be used to control such passage. The tip portion and the shaft portion can be used to dilate the flexor tendon sheath. The severed flexor tendon can be attached to the tip portion, and the tool can be withdrawn from flexor tendon sheath to pass the severed flexor tendon to a repair site.
US08506584B2 Fluid jet device, drive device of fluid jet device, surgical instrument, and method of driving fluid jet device
A fluid jet device including a fluid chamber with variable capacity and a capacity varying section adapted to vary the capacity of the fluid chamber in response to supply of a drive signal. A drive waveform section making the capacity varying section operate so as to compress the capacity of the fluid chamber and a restoring drive waveform section making the capacity varying section operate to restore the capacity of the fluid chamber before compressing the capacity in a signal waveform. The drive signal supply section controls supply content of the drive signal to provide a restoring period adapted to restore a steady state of the fluid flowing toward an inside of the fluid chamber in a period from when the compressing drive waveform section in the drive signal is supplied to when a subsequent compressing drive waveform section is supplied.
US08506581B2 Flexible endoscopic stitching devices
An endoscopic stitching device includes a tool assembly having a pair of juxtaposed jaws pivotally associated with one another, each jaw defining a needle receiving recess formed in a tissue contacting surface thereof; a drive assembly including a pair of concentric, individually rotatably and translatably supported barrels, each barrel defining a central lumen therethrough; and a pair of axially translatable needle engaging blades slidably supported, one each, in a respective jaw. The stitching device further includes a center rod slidably and rotatably disposed through the lumen of the barrels, a distal end of the center rod being operatively engaged with the pair of jaws.
US08506579B1 Hair threading clips
A set of clips, with finger placement for the use of fingers of both hands, and thread tied in a loop, slipped at a groove/notch/slot of each clip and then twisted, for the purpose of self threading (removing) hairs. The set of clips allows for a pain free experience when self threading using just a loop of thread around the fingers. The opening of the arms of the clips as well as the opening of the loop is comparable to the opening of the fingers when used with thread alone. Thus resulting in the exact duplication of threading done by a trained practitioner or self threading performed with a loop of thread.
US08506578B2 Polypectomy snare instrument
A medical device and methods for making and using the same. An example medical device includes a tubular member, a shaft disposed within the tubular member, and an end effector coupled to the shaft. A first handle and a second handle may be coupled to the shaft. A tubular sheath extension may be disposed between the first handle and the second handle.
US08506574B2 Percutaneous compression and distraction system
A compression and distraction shaft assembly applies compression and distraction to bones including vertebrae. Shaft A assembly and shaft B assembly are attached together via a polyaxial fulcrum. The polyaxial fulcrum allows all rotational degrees of freedom between shaft A assembly and shaft B assembly. Such fulcrum, during compression and distraction, does not impart ancillary stresses or motion to vertebrae. An hourglass-shaped bore for engaging pliers is formed in approximately middle of both the shaft A assembly and the shaft B assembly. Distraction pliers having cylindrical tips are used to apply distraction to vertebrae. Once handles are pressed to impart an appropriate amount of distraction to the vertebrae, they are locked in this position. Compression pliers having cylindrical tips are used to apply compression to vertebrae. Once handles are pressed to impart an appropriate amount of compression to the vertebrae, they are locked in this position.
US08506573B2 Offset drill guide and arthroscopic method
A cannulated offset drill guide and surgical methods for repairing Bankart lesions. The cannulated offset drill guide comprising a shaft which is offset from the guide center line by about 1 to 3 mm, more preferably of about 1.5 mm. The cannulated offset drill guide is provided at its proximal end with a concave clear tip which allows a surgeon to visualize the drill and the insertion of an anchoring device, for example a suture anchor. The concave clear tip has beveled, smooth edges to prevent damage to adjacent bone and tissue, and to avoid damage to the rubber dam of the cannula through which the offset drill guide is inserted. The configuration of the concave clear tip is designed to engage and match the generally convex-curve articulating face of the glenoid, and to precisely aligning the offset drill guide with the glenoid face. The clear tip may also be employed in a standard drill guide having a shaft which is not offset from the center line of the guide.
US08506570B2 Burr guide assembly
A burr guide assembly is described for guiding a burr tool during a procedure wherein the burr tool is used to cut a bone. The guide assembly includes a housing which is configured to be attached to the bone, a guide sleeve attached to the housing such that the guide sleeve can freely pivot about a pivot axis within a defined range, and a burr tool. The guide sleeve has a bore that extends along its length, which is located eccentrically within the guide sleeve. The burr tool has a cutting portion that is configured to be at least partially disposed within the bore. The guide sleeve is mounted within the housing such that the cutting portion is substantially restricted to movement in a plane that is perpendicular to the pivot axis.
US08506565B2 Electrosurgical device with LED adapter
The present disclosure includes an electrosurgical instrument which further includes a housing having distal and proximal ends. The electrosurgical instrument also includes a light-emitting diode adapter having distal and proximal ends configured to selectively engage the distal end of the housing. The light-emitting diode adapter also includes at least one light-emitting diode disposed therein. The light-emitting diode is adapted to connect to an electrosurgical energy source and being selectively activatable to emit light from the adapter. The at least one electrode is configured to selectively engage the distal end of the light-emitting diode adapter and adapted to connect to the electrosurgical energy source.
US08506563B2 Moisture transport system for contact electrocoagulation
An apparatus and method for use in performing ablation or coagulation of organs and other tissue includes a metallized fabric electrode array which is substantially absorbent and/or permeable to moisture and gases such as steam and conformable to the body cavity. The array includes conductive regions separated by insulated regions arranged to produce ablation to a predetermined depth. Following placement of the ablation device into contact with the tissue to be ablated, an RF generator is used to deliver RF energy to the conductive regions and to thereby induce current flow from the electrodes to tissue to be ablated. As the current heats the tissue, moisture (such as steam or liquid) leaves the tissue causing the tissue to dehydrate. Suction may be applied to facilitate moisture removal. The moisture permeability and/or absorbency of the electrode carrying member allows the moisture to leave the ablation site so as to prevent the moisture from providing a path of conductivity for the current.
US08506561B2 Catheter with inductively heated regions
An electrical conductor, such as a wire or catheter, which is coated circumferentially with a ferromagnetic material in a selected region, is fed from a high frequency alternating current source. The ferromagnetic material has a quick response in heating and cooling to the controllable power delivery. The ferromagnetic material can be used for separating tissue, coagulation, tissue destruction or achieving other desired tissue effects in numerous surgical procedures.
US08506556B2 Robotic arm with five-bar spherical linkage
A robotic arm for a minimally invasive surgical system includes a parallel spherical five-bar linkage adapted to spherically rotationally move a robotic surgical tool coupled to the parallel five-bar spherical linkage about a remote center of spherical rotation. The five-bar spherical linkage is posed in only a range of compact poses. A compact pose is one in which a first pair of links and a second pair of links in the parallel five-bar spherical linkage have only a same handedness.
US08506553B2 Coronary sinus lead delivery catheter
A guide catheter assembly includes an outer guide catheter and an inner catheter slidably and rotatably disposed in the outer guide catheter. The outer guide catheter has a proximal portion and a distal portion formed into a preformed shape including a curved segment. The preformed shape includes a first arc, a second arc, a third arc, a fourth arc, and a generally straight terminal portion. The preformed shape is generally a J-shape, having a terminal portion generally parallel to the proximal portion, a generally closed arc or a generally open arc.
US08506551B2 Infiltration cannula
An infiltration cannula and method of using the infiltration cannula during a tumescent infiltration procedure are disclosed herein. The infiltration cannula may have an outwardly flaring hub which may be wedged into an adit of a patient to minimize leakage of fluid being infiltrated into the patient. Also, the infiltration cannula may be utilized to hydrate a dehydrated patient by a medically untrained person. The infiltration cannula may also be used to deliver an antibiotic/vasoconstrictive drug solution to minimize surgical site infections.
US08506548B2 Connector
One end of a tubular portion (16) is sealed with a stopcock (5) that is fitted in the tubular portion (16). A first flow channel (33) and a second flow channel (36) are formed in the stopcock (5). A first hole (37), a second hole (43), a third hole (38), and a fourth hole (44) are formed in a connector main body (2). Switching between a setting that brings an inner space (16a) of the tubular portion (16) into communication with the first hole (37) via the first flow channel (33) and a setting that brings the inner space (16a) of the tubular portion (16) into communication with the second hole (43) via the first flow channel (33) and brings the third hole (38) into communication with the fourth hole (44) via the second flow channel (36) can be achieved by rotating the stopcock (5).
US08506543B2 Anatomically conforming vaginal insert
A vaginal insert formed from a composition that, prior to introduction to the vagina, has the physical properties of a liquid, semi-soft gel, paste, foam, or viscous material so that it can be effectively delivered to the vaginal canal. After introduction into the vagina, the composition will expand and/or solidify into a semi-solid or solid structure to substantially fill the entire “H” shaped space of the vagina and a portion of the rugal folds along the length of the vaginal canal. Upon solidifying, the composition defines an insert that, in one embodiment, is suitable for use as a tampon and, in another embodiment, is suitable for use as an incontinence device.
US08506541B2 Ostomy appliance comprising a wicking layer
An ostomy appliance includes a base plate having an inner radial boundary defining a stoma receiving opening and an outer radial boundary defining an outer edge of the base plate. The base plate has an adhesive layer with a first surface for attaching the base plate to skin surrounding the stoma and a second surface opposite the first surface, and a first liquid impermeable layer having a first surface covering the second surface of the adhesive layer. A second surface opposite of the first liquid impermeable layer is provided with a wicking material abutting the inner radial boundary of the stoma receiving opening. The wicking material extends in a radial direction towards the outer edge of the base plate and away from the stoma receiving opening.
US08506524B2 User interface for delivery system comprising diary function
A device for displaying information is provided. The device includes data storage circuitry for storing data, a display configured to display data to a user, a processor configured to control the display and the data storage circuitry, and user input circuitry. The processor is configured to control the display based on user input to: graphically display an aggregate period view having at least two period views, graphically display a single period view, graphically display a data type symbol corresponding to a given data type, graphically display at least one data type symbol for every period view, and display a card view including information data corresponding to a selected data type symbol.
US08506522B2 Peritoneal dialysis machine touch screen user interface
A peritoneal dialysis machine including a membrane pump and a touch screen display that includes a mode-indicating portion and an operation-descriptive portion, the mode-indicating portion having a plurality of touch sensitive indicia each indicating one of a plurality of modes in which the machine can operate, the display being used to keep a patient continually informed of which one mode of at least three operating modes the machine is operating in, as the operation-descriptive portion changes to display details of a specific operation being carried out within the one mode, the indicia for each of the three operating modes always being visible to the patient while the machine is operating, the operating mode being selected by the patient touching one of the indicia on the screen.
US08506516B2 Devices, systems, and methods for achieving magnetic gastric bypass
Devices, systems and methods are disclosed for the treatment of obesity. A magnetic device is provided that enables the creation of a Roux limb without the use of staples or sutures. Additionally, a magnetic device is described for extending the length of the Roux limb such that tension in the stomach and/or the intestines is prevented. Further, a system and method are described for achieving the reversible restriction of gastric capacity and bypass of the duodenum without the use of sutures or staples.
US08506513B2 Blood reservoir with ultrasonic volume sensor
A perfusion system that is easy to set-up, use and monitor during a bypass procedure includes at least some disposable components configured to communicate parameters to the perfusion system. An ultrasonic blood level sensor can be used to monitor a blood level or volume within a blood reservoir. The blood level sensor may be utilized in an integrated perfusion system in which the disposable components are configured, as noted above, to communicate with the perfusion system.
US08506511B2 Method and device for removal of radiocontrast media from blood
An extracorporeal blood circuit including: a withdrawal conduit connectable to a coronary withdrawal catheter; a withdrawal pump connectable to the withdrawal conduit, wherein a pumping rate of the withdrawal pump determines a blood withdrawal rate from the coronary withdrawal catheter; a filter having an input connected to the withdrawal conduit and a blood output connected to an infusion conduit and a filtrate output connected to a filtrate conduit; a filtrate measurement device to determine an amount of filtrate removed from the blood in the filter; a fluid supplementation conduit providing a blood replacement fluid to at least one of the withdrawal conduit, filter and infusion conduit; a supplementation pump connectable to the fluid supplementation conduit, wherein a pumping rate of the supplementation pump determines a rate at which the blood replacement fluid flows into the blood flowing through the blood circuit, and a controller regulating the pumping rate of the supplementation pump such that the rate of the blood replacement fluid provides an amount of blood replacement fluid to the at least one of the withdrawal conduit, filter and infusion conduit so as to substantially match the amount of filtrate removed.
US08506508B2 Compression device having weld seam moisture transfer
A compression sleeve includes a wicking layer secured to bladder material defining an inflatable bladder along a seamline. Fibers of the wicking layer extend through the seamline to allow fluid wicked by the wicking layer from the wearer's skin to evaporate to the atmosphere.
US08506507B2 Venous augmentation system
A method for augmenting blood flow in a limb that is wrapped with a sleeve having at least one chamber for applying compression to the limb in a region generally underlying the chamber includes pressurizing the chamber to a first compression pressure and then reducing the pressure to a refill pressure. Pressure in the chamber is then sensed to determine a first venous refill time. The preceding steps are repeated a second and other times using second and other compression pressures that are different from the first compression pressure and from each other to determine second and other venous refill times. A customized compression pressure is determined by locating the compression pressure at which blood flow out of the region generally underlying the chamber is maximized by finding compression pressure at a maximum venous refill time. A compression device employing such a method is also disclosed.
US08506497B2 Continuous positioning apparatus and methods
Improved apparatus and methods for non-invasively assessing one or more parameters associated with systems such as fluidic circulating systems (e.g., the circulatory system of a living organism). In a first aspect, an improved method of continuously measuring pressure from a compressible vessel is disclosed, wherein a substantially optimal level of compression for the vessel is achieved and maintained using dynamically applied dither perturbations (e.g., modulation) on the various axes associated with the vessel. In a second aspect, an improved apparatus and method are provided for monitoring hemodynamic parameters, such as blood pressure, in a continuous and non-invasive manner while operating under a single unifying scheme. One variant of this scheme using a simulated annealing (SA) type approach to determining and maintaining an optimal operating state.
US08506495B2 Implantable medical devices with piezoelectric anchoring member
Methods, systems, and apparatus for powering and/or recharging medical devices implanted within the body are described. An illustrative implantable medical device includes a housing having an internal cavity and a flexible anchor assembly that is coupled to the housing. The flexible anchor assembly includes a first electrical conductor, a second electrical conductor, and a piezoelectric layer that is disposed between the first and second electrical conductors and that is configured to displace in response to a physiologic force applied to the flexible anchor assembly and generate a voltage differential between the first and second electrical conductors. The implantable medical device includes power circuitry that converts the voltage differential between the first and second electrical conductors into an operating current for powering one or more components within the implantable medical device and/or for recharging a rechargeable power supply within the device.
US08506494B2 Method and apparatus for controlling a patient's body temperature by in situ blood temperature modification
The present invention provides a method and apparatus for controlling the internal body temperature of a patient. According to the present invention, a catheter is inserted through an incision into a large blood vessel of a patient. By selectively heating or cooling a portion of the catheter lying within the blood vessel, heat may be transferred to or from blood flowing within the vessel and the patient's body temperature may thereby be increased or decreased as desired. The invention will find use in treating undesirable conditions of hypothermia and hyperthermia, or for inducing a condition of artificial hypothermia when desired. The method and system further provide for the cooling of initially hypothermic patients whose blood or body temperature has been warmed above the desired target level and the warming of initially hyperthermic patients whose blood or body temperature has been cooled below the desired target temperature.
US08506490B2 Real time ultrasound probe
An external ultrasound transducer probe assembly capable of scanning a three-dimensional volume is provided. The ultrasound transducer probe assembly contains a plurality of ultrasonic transducers disposed along a longitudinal axis of the probe assembly. The plurality of ultrasonic transducers is disposed on a mechanism operable to reciprocally pivot the plurality of ultrasonic transducers enabling the plurality of ultrasonic transducers to scan the entire three-dimensional volume. A helically disposed electrical interconnection member may be disposed about a pivot axis of the plurality of ultrasonic transducers and may electrically interconnect the plurality of ultrasonic transducers to an ultrasound imaging system. The ultrasound transducer probe assembly may be fluid filled and contain bubble position control and fluid expansion compensation features.
US08506489B2 Ultrasonograph
Provided is an ultrasonograph that can automatically optimize the sweep rate of Doppler images and M-mode images according to the heart rate of a test subject, without the need for an operator to perform a troublesome operation. The ultrasonograph is provided with a means for sending an ultrasonic beam into body tissue, a means for receiving an ultrasonic signal that has been reflected off the body tissue and a blood flow, a means for constructing a cross-sectional image of the body tissue from the received ultrasonic signal, a means for performing phase detection on an ultrasonic Doppler blood flow signal that has been reflected off the body tissue by the blood flow, a means for calculating a frequency component of the Doppler blood flow signal on which phase detection has been performed, and a means for performing a sweeping display of the calculated frequency component as Doppler images in a time series. The ultrasonograph has a heart rate measuring means for measuring the heart rate of the test subject at a predetermining timing, and the ultrasonograph also includes an optimum sweep rate calculating means for calculating an optimum sweep rate based on the heart rate obtained by the heart rate measuring means, and an optimum sweep rate setting means for setting the sweep rate of at least either of the Doppler images and M-mode images.
US08506485B2 Devices and methods for treatment of tissue
Delivery systems, and methods using the same, having an ultrasound viewing window for improved imaging and a needle for ablation treatment of target tissues. In an embodiment, the target tissue is a fibroid within a female's uterus. In an embodiment, the delivery system includes a rigid shaft having a proximal end, a distal end, and an axial passage extending through the rigid shaft. In an embodiment, the axial passage is configured for removably receiving the ultrasound imaging insert having an ultrasound array disposed a distal portion.
US08506480B2 Device for determining respiratory rate and other vital signs
A body-worn sensor that measures respiratory rate and other vital signs using an acoustic sensor (e.g., a small-scale sensor). The body-worn sensor features a chest-worn patch sensor that combines both the acoustic sensor and an ECG electrode into a single adhesive patch. To measure blood pressure, the device additionally performs a ‘composite’ PTT-based measurement that features both pressure-dependent and pressure-free measurements. The acoustic sensor measures respiration rate by recording sounds related to the patient's inspiration and expiration. The acoustic sensor is typically placed near the patient's trachea, but can also be placed on the middle right and left side of the chest, and the middle right and left side of the back.
US08506476B1 Injection device for endoscopy
A medical device for injection during endoscopy or arthroscopy, the device having a curved, hollow needle, optionally coated by a semi-rigid covering, all surrounded by a curved tubular sleeve, wherein the needle is attached to a base, separated from the sleeve by one or more removable extensions or tabs, and a connection means for connecting either directly to a syringe for a liquid or semi-liquid treatment or to an extension tube connected to such a syringe.
US08506475B2 Flexible scope endoscope
A flexible endoscope for extending between an incision and a surgical site, the flexible endoscope including an endoscopic cylinder received by an outer flexible sleeve, the endoscopic cylinder including an outer contact surface received by the flexible sleeve with a helical thread, a flanged structure associated with the flexible sleeve and corresponding to a proximate handle end of said endoscopic cylinder, and a directional guide angularly extending from said outer surface and tapered.
US08506470B2 Sensorless flow estimation for implanted ventricle assist device
A method of estimating the blood flow rate of a heart ventricle assist device which is positioned externally of, or implanted in, a patient. The assist device comprises a blood pump having a rapidly rotating, electrically powered impeller, and comprises briefly interrupting power to the impeller to cause its rotation to slow. From this, blood viscosity can be estimated, which viscosity is used to obtain real time, estimated blood flow rates and pressure heads. Apparatus for accomplishing this is disclosed.
US08506468B2 Ferrofluidic cooling and acoustical noise reduction in magnetic stimulators
A ferrofluid chamber has a housing that is adapted to be coupled to a component that generates a magnetic field of sufficient strength to stimulate anatomical tissue. In addition, a ferrofluid is disposed within the housing for cooling the component.
US08506467B2 Process for solidifying organic and inorganic provisional constituents contained in produced water from heavy oil operations
A process is provided for treating produced water recovered from an oil recovery process. An oil-water mixture is collected from an oil bearing formation. The oil-water mixture is directed to a separator that separates the oil-water mixture to yield produced water and an oil product. The produced water includes water, dissolved organics and dissolved inorganic solids. The produced water is directed to a crystallizer. In the crystallizer, the produced water is concentrated by heating the produced water. Concentrating the produced water causes the organic and inorganic solids to precipitate from the produced water and form solid crystals, including salt crystals. Further, concentrating the produced water in the crystallizer produces an organic melt including the solid crystals. Thereafter, the method or process entails cooling the organic melt such that the organic melt solidifies into an organic solid structure, and wherein substantially no free water is present in the organic solid structure.
US08506460B2 Exercise apparatus for exercising
An exercise apparatus used for exercise and more specifically musculoskeletal physical therapy and rehabilitation purposes. The exercise apparatus particularly, but not exclusively, uses a combination of weight, a structure adapted for weight training by a person, and a means to suspend the weight wherein the suspended weight is adapted to have motion in the x, y and z axis during an exercise movement that results in increased joint strength and decreased joint pain during and after physical therapy and rehabilitation exercises.
US08506456B2 Exercise apparatus
An apparatus for replicating swimming, rowing, cycling or other exercise modalities. An apparatus includes a base, a frame extending up from the base, and a support member coupled to a top portion of the frame. The apparatus further includes a forward-ascending bench. The bench includes a torso support section to support a user's torso, pivotally coupled to the support member, and configured for limited angular rotation about an axis parallel to at least a portion of the support member. The bench further includes left and right leg support sections, pivotally coupled to the torso support section, to support at least the user's thighs. The apparatus also includes a coupling member extending forward from the base, and configured to interchangeably couple with an exercise module.
US08506454B2 Fluid pressure control device for automatic transmission
A fluid pressure control device including a first pump actuated by power from a motor; a pressure regulator that regulates a discharge pressure from the first pump; a second pump actuated by electric power; a switcher opening a first path extending from the pressure regulator to a fluid pressure chamber of a friction engagement element, and blocking a second path extending from the second pump to the fluid pressure chamber of the friction engagement element, when the signal pressure is equal to or more than a set pressure, and the switcher blocking the first and opening the second paths when the signal pressure is less than the set pressure; and a control that controls the second pump and the fluid supply unit to supply the fluid regulated by the pressure regulator to a destination different from the fluid pressure chamber of the friction engagement element when the motor is stopped.
US08506450B2 Hybrid vehicle
Disclosed is a hybrid vehicle with a transmission, the transmission including a transmission input shaft (25) to which the power from the engine is transmitted, transmission output shafts (26, 27) from which a power for driving a driven section is outputted, a first input shaft (21) which is connectable to the transmission input shaft (25) via a first clutch (CL1) of a twin clutch unit (20), a second input shaft (22) which is connectable to the transmission input shaft (25) via a second clutch (CL2), gear trains (G1 to GR) which are configured so that the gear trains can be selected to connect the first input shaft (21) and the second input shaft (22) to the transmission output shafts (26, 27), and a connection device (SM1) which can be selectively switched between a first operation state for enabling power transmission between the output shaft of an electric motor (3) and the transmission input shaft (25) and a second operation state for interrupting the power transmission therebetween.
US08506449B2 Control system
A control system configured with a speed change mechanism. When starting combustion in an internal combustion engine under a combustion-stopped vehicle running condition, the combustion in the internal combustion engine is stopped, the speed change mechanism forms the one-way transmission speed, and the output member rotates. A rotational speed feedback control is executed that sets a value that multiplies a rotational speed of the output member by a speed ratio of the one-way transmission speed as a reference rotational speed of the input member, sets a starting rotational speed, and controls a rotary electric machine such that the rotational speed of the input member matches the target rotational speed. During execution of the rotational speed feedback control, a start control is performed that increases engagement pressure of the clutch to increase a rotational speed of the internal combustion engine and start combustion in the internal combustion engine.
US08506448B2 Hybrid vehicle
A power split mechanism of a hybrid vehicle includes a sun gear that is coupled to a electric power generator, a ring gear that is coupled to a electric motor and a driving wheel, a pinion gear that meshes with the sun gear and the ring gear, and a carrier that supports the pinion gear and is coupled to a engine. Each of the arms of a inverter includes a first switching element that is provided on an upper arm thereof, and a second switching element that is provided on a lower arm thereof. A control device turns on one of the first switching element and the second switching element and turns off the other if an operation of stopping a vehicle system is performed during running.
US08506443B2 Planetary gear train of automatic transmission for vehicles
A planetary gear train of an automatic transmission may include an input shaft configured to receive an engine torque, an output shaft configured to output a shifted torque, a first compound planetary gear set including first and second simple planetary gear sets having first and second sun gears, first and second planet carriers, and first and second ring gears as rotation elements, a second compound planetary gear set including third and fourth simple planetary gear sets having third and fourth sun gears, third and fourth planet carriers, and third and fourth ring gears as rotation elements, seven rotational shafts connecting to one to more rotation elements, and seven friction members including three clutches interposed between a rotational shaft and the input shaft to control the torque and four brakes selectively connecting a rotational shaft to a transmission housing.
US08506441B2 Differential gear for a multi-shaft wheeled motor vehicle, and a drive train comprising several such differential gears
A differential gear, comprising a first releasable lock (42, 44) between a crown wheel (14) and the one drive shaft, a second, releasable lock (66, 68) between the crown wheel (14) and a differential housing (24), and a third releasable lock (74, 76) between the differential housing (24) and fixed vehicle part (26). The second and third locks are designed to be opened and locked alternately with one another. It is thereby possible to achieve drive shafts rotating in opposite directions to one another on the left and right side of the vehicle and thereby to achieve a center swiveling of the vehicle when the first lock (42, 44) is simultaneously kept in the locked position.
US08506438B2 Cycloidal speed reducer, in-wheel motor drive device, and vehicle motor drive device
A speed reducer part includes a casing, an input shaft arranged in the casing, eccentric members eccentric with respect to an axis of the input shaft and coupled to an end of the input shaft, revolution members supported by outer circumferences of the eccentric members through a rolling bearing, to make a revolution motion around the axis together with a rotation of the input shaft, an outer circumference engagement member engaging with outer circumferential parts of the revolution members to cause the revolution members to make a rotation motion, and an output shaft engaging the revolution members to extract the rotation motion. A bearing lubricant oil hole supplies oil to a surface in rolling contact with a rolling body. The lubricant oil hole is arranged in a non-load range, where a load applied from the output shaft and the outer circumference engagement member to the revolution members is not shared.
US08506436B2 Bicycle chain rings with ramps
Embodiments of the present invention include bicycle chain rings for bicycles having specially shaped ramps, tapers and profiled teeth for improved shifting performance. Additional embodiments of the bicycle chain rings of the present invention may be configured with one or more additional features formed within the chain rings including a transition slide, a tapered ramp face, a ramp bridge, a ramp lead, a trailing transition slide and a wear pin.
US08506435B2 Belt drive system assembly and tension apparatus
Tension apparatus for a belt drive system. The tension apparatus includes a first component that is movable between a first tension position corresponding to a first belt length and a second tension position corresponding to a second belt length that is longer than the first belt length. The tension apparatus also includes a second component, a first component bracket coupled to the first component and defined by a first surface having a first perceptible indicator, and a second component bracket coupled to the second component and located adjacent the first component bracket. The second component bracket is defined by at least one second surface that has second perceptible indicators. The first perceptible indicator is selectively alignable with one of the second perceptible indicators in response to movement of the first component to one of the first and second tension positions such that tension of the belt is adjustable.
US08506431B2 Archery broadhead
A broadhead arrow having a body and at least two removable blades attached to the body. The blades being locked into a place by a lock washer that slides over the rear portion of the body and is secured between the broadhead point and the arrow shaft. Removal of the washer allows for easy removal and replacement of the blades.
US08506426B2 Game of lobol
A method of playing a game called lobol, and a kit to facilitate playing it. The lobol is a small, solid ball. In addition to the lobol, the game requires one or more larger balls. A third element of equipment is a goal that has an opening large enough to admit the lobol, but small enough to exclude the larger ball. The game is played by placing the lobol on a playing field between a starting point and the goal enclosure. One player is designated as the “player in possession”. That player propels one of the balls towards the lobol with the intention of moving the lobol into the goal, thereby scoring a goal. The player in possession continues throwing the ball at the lobol, until they miss. The other player then takes over as the player in possession, and they attempt to move the lobol into the goal.
US08506424B2 Golf ball having a thermosetting intermediate and outer cover and thermoplastic inner cover
A golf ball is formed including a core and a cover. The cover includes a thermoplastic inner cover layer and having a hardness between 55 and 60 Shore D, an outer cover layer having a hardness between 55 and 60 Shore D, and a non-ionomeric thermosetting polyurethane or polyurea intermediate cover layer disposed between the inner and outer cover layers. The intermediate cover layer has a hardness greater than the inner cover layer hardness and the outer cover layer hardness. The inner cover is formed from a partially- or fully-neutralized ionomer and the outer cover layer is formed from a polyurethane, a polyurea, or a urethane-urea blend.
US08506413B2 Rotary connector
A rotary connector, comprises an annular rotary body inserted outside a steering shaft and integrally rotated with a steering wheel, a rotator of a steering angle sensor inserted outside the steering shaft; and a tubular joint inserted outside the steering shaft and connecting the rotary body to the rotator; wherein the rotary body and the joint are connected together by a first universal joint, and the joint and the rotator are connected together by a second universal joint.
US08506409B2 Clan wars
A method of implementing clan wars is disclosed. An incentive reward is generated that is to be provided to at least one member of a group of users of a game networking system based on the group exercising a level of influence over a location during a time period that is greater than a level of influence of an additional group of users over the location during the time period. It is determined that the group exercised the level of influence over the location during the time period. The incentive reward is provided to the at least one member of the group based on the determining that the level of influence exercised by the group is greater than the level of influence of the additional group over the location during the time period.
US08506406B2 Network access device and method to run a game application
A network access device and method to run a gaming application on a network access device are described. The network access device comprises a communications module configured to allow the network access device to communicate with a network. The network access device is configured to transmit user identification information to a verification system and transmit security information to a verification system. When the user identification information and security information have been verified by the verification system, the network access device receives a random game output generated by a gaming system.
US08506404B2 Wireless gaming method and wireless gaming-enabled mobile terminal
A wireless gaming method and wireless gaming-enabled mobile terminal are provided for enabling a number of players to participate simultaneously in a game using their mobile terminals. A wireless gaming method of the present invention includes inviting, if a multi-player gaming mode for a game is activated, at least one counterpart terminal on a short range wireless communication network by transmitting a multi-player gaming mode request message; synchronizing, if an acknowledge message is received in response to the multi-player gaming mode request message, game data with the counterpart terminal transmitted the acknowledge message; and generating a game screen with an image taken by the camera as a background image after the game is synchronized; and starting the game with the game screen.
US08506403B2 Multigame selection
A gaming system comprises a gaming server, a plurality of gaming machines, and a communications system connecting each of the plurality of gaming machines to the gaming server. The gaming machines each have a display, player controls, a player tracking device, and a game processor which displays sequential game images of a game being played. Each game processor plays a game initiated by the player, where the game is one of a plurality of games available on the gaming machine and selectable by the player. Each gaming machine includes game selection means which displays a selection of games available on the machine for the player to play. The games offered for selection are ordered according to a ranking determined as a function of the player's past history of playing games and a history of games played by other players.
US08506399B2 Configuring and controlling wagering game audio
A wagering game system and its operations are described herein. In embodiments, the operations can include determining an occurrence of an application event for an application that runs in association with a wagering game machine. The operations can further include accessing a custom sound source that includes customized sounds presentable separately from a soundtrack for the application, during a wagering game session on the wagering game machine. The operations can further include determining a custom sound, from the custom sound source, that relates to the application event and determining custom-sound presentation instructions associated with the custom sound. The operations can further include presenting the custom sound on sound production devices associated with the wagering game machine during the application event according to the custom-sound presentation instructions.
US08506394B2 Tournament gaming systems, gaming devices and methods
Various embodiments are directed to gaming systems, gaming devices, and methods for presenting tournament games. According to one embodiment, a gaming device provides a base game in a normal, non-tournament mode, and the player's eligibility to play a tournament game is also determined. An eligible player is prompted to select a desired tournament game from a list of available tournaments while base game is in the normal, non-tournament mode. In response to the player's selection of a tournament game, the gaming device is reconfigured from the normal mode to a tournament mode. The gaming device processes game play in the tournament mode and creates a final tournament score for the player. At the conclusion of the tournament game on the gaming device, the gaming device is reconfigured into the normal, non-tournament mode.
US08506392B2 Progressive wagering game with personalized reset-value feature for players meeting predetermined criteria
A gaming system includes a plurality of gaming terminals for playing wagering games that provide access to a progressive game having multiple progressive jackpots. Each progressive jackpot has a base reset value that increases in response to wager inputs. The gaming system comprises at least one controller operative to determine that a first player at a first gaming terminal has achieved a predetermined criteria, and to provide an award associated with one of the multiple progressive jackpots to a second player at a second gaming terminal who triggered the awarded jackpot. The controller maintains the value of the awarded progressive jackpot for the first player who achieved the predetermined criteria at the awarded value, but resets the awarded progressive jackpot to the lower base reset value for other gaming terminals. Thus, the first player benefits from a potentially higher jackpot award value due to achieving the predetermined criteria.
US08506390B2 Wagering game having game assets with multiple levels of enhancement
A gaming system includes an input device, at least one display, and at least one controller. The input device receives a wager input for playing a wagering game. The at least one display displays a basic wagering game and a community bonus game. The at least one controller is operative to provide a player with a bonus-game asset that is usable in at least a first play of the community bonus game. The bonus-game asset is capable of having at least a first level and a second level that provides a higher bonus-game enhancement than the first level. The at least one controller is further operative to determine if that the bonus-game asset is available to the player for use in a second play of the community bonus game and to alter the level of the bonus-game asset from the first level to the second level for use in the second play.
US08506388B2 Method and apparatus for conditional payouts in a gaming device
A gaming device incentivizes additional game play by combining payouts with conditional payouts. During game play, players are informed of the conditions, which must be satisfied so as to vest the conditional payouts. Subsequent game play is monitored to see if the player has satisfied the conditions. If the player has satisfied the conditions, then the conditional payout vests. If the condition is not met, then the conditional payout terminates.
US08506386B2 Method and apparatus for awarding wins for game play
A method of awarding wins for game play comprises determining winning outcomes from all possible outcomes of game play and assigning at least one of two different types of awards, such as either or both primary and secondary credit awards, to each winning outcome. Preferably, the winning combinations and associated awards are selected so that, when assigned to a secondary event, the outcome of the game may be represented as the outcomes of a secondary event. In one embodiment, the outcomes of a Class II game, such as bingo, are represented by outcomes Class III type event, such as the game of slots. In accordance with the invention, the representation of the game outcomes mimics the frequency of wins and the payouts associated for those wins in a true Class III game, including as dependent upon the size of a player's wager.
US08506382B2 Slot machine game for two players
Disclosed are two-player games, gaming machines, gaming systems and methods including one or more shared feature games. Each player has a respective base game, game board and a token movable on his game board in response to his base game outcomes. Certain combinations of token positions on the two game boards may trigger play of one or more feature games shared by the players.
US08506380B2 Gaming system, gaming device, and method for enabling a player to select volatility using game symbols
Various embodiments of the gaming system, gaming device, and gaming method disclosed herein provide a primary game and a free activation bonus sequence, wherein the gaming system enables the player to select one or more of a plurality of different volatility options for use in the free activation bonus sequence. Each option is associated with a different number of free activations and a different pool of symbols or different symbol functionality. The gaming system provides this variation in the pool of symbols or symbol functionality in various embodiments by enabling the player to replace one or more symbols of a pool or set of symbols of the primary game (i.e., the primary set of symbols) with the symbol associated with a player selected option. The symbols of this modified set of symbols (i.e., the secondary set of symbols) are used in the free activation bonus sequence.
US08506373B2 Amusement device prize awarding system and method
An amusement device that awards prizes has a display and an input device. The amusement device includes a memory that stores at least one electronic game and a system control program. The at least one electronic game has a plurality of play scenarios and is at least partially skill-based. The amusement device also includes a controller operatively coupled to the memory, the input device and the display. The controller controls the display based upon the system control program retrieved from the memory and based upon inputs from the input device. The controller is configured to permit the user to selectively retrieve from the memory and play the at least one electronic game and determine at least one of an optimum series of requisite moves that will result in an optimal achievable score for a particular play scenario selected from a plurality of play scenarios.
US08506372B2 System and method configured to provide a location-based vehicular racing videogame
A system and method are configured to provide a videogame to one or more players. The videogame may involve a series of different virtual geographic locations at which players perform activities. A group of players may be associated with each location. The players may include virtual players controlled by artificial intelligence and one or more real world players. Players may progress through the videogame by moving from location to location, performing objectives at the various locations, and interacting with the players at the locations.
US08506367B2 Mobile air cleaning unit and distribution system
A mass transit vehicle including a cabin mounted to a frame and including a roof and a passenger zone defining a passenger zone length, an air cleaning unit including an air cleaner housing mounted to the roof, an air cleaning device disposed within the housing, an inlet upstream of the air cleaning device, and an outlet downstream of the air cleaning device, and a duct system disposed within the cabin and extending substantially along the passenger zone length. The air cleaning unit is operable to draw in air through the inlet, through the air cleaning device, and discharge a flow of cleaned air out of the outlet, and the duct system is in fluid communication with the outlet and operable to receive the flow of cleaned air from the outlet and direct the flow of cleaned air to the cabin substantially evenly along the passenger zone length.
US08506365B2 Method and processing line for processing poultry
Method and processing line for stunning and/or killing of poultry, comprising a plurality of treatment stations to execute the stunning and/or killing of poultry contained in containers or crates, a feed-line for supplying the poultry in containers or crates to the plurality of treatment stations, and an exit line to transport the stunned and/or killed poultry contained in the containers or crates away from the treatment stations, wherein a shuttle unit is provided that is movable on the one part to and from the plurality of treatment stations and on the other part to and from the feedline and the exit line.
US08506359B2 Aqueous dispersion for chemical mechanical polishing and chemical mechanical polishing method
A chemical mechanical polishing aqueous dispersion including (A) silica particles, and (B1) an organic acid, the sodium content, the potassium content, and the ammonium ion content of the silica particles (A) determined by ICP atomic emission spectrometry, ICP mass spectrometry, or ammonium ion quantitative analysis using ion chromatography having a relationship in which the sodium content is 5 to 500 ppm and at least one of the potassium content and the ammonium ion content is 100 to 20,000 ppm.
US08506356B2 Apparatus and method for in-situ endpoint detection for chemical mechanical polishing operations
An apparatus for chemical mechanical polishing (CMP) of a wafer has a rotatable platen to hold a polishing pad, a polishing head for holding the wafer against the polishing pad, an optical monitoring system and a position sensor. The platen has a hole therein, the optical monitoring system includes a light source to direct a light beam through the aperture toward the wafer from a side of the wafer contacting the polishing pad and a detector to receive reflections of the light beam from the wafer, and the position sensor senses when the hole is adjacent the wafer such that the light beam generated by the light source can pass through the hole and impinge on the wafer.
US08506354B2 Cup attaching apparatus
A cup attaching apparatus for attaching a cup serving as a machining jig on a surface of a lens comprises: a white LED which is an illumination light source for illuminating the lens placed on a lens supporting member; a screen applied with an alignment mark, on which screen an image of the lens illuminated by illumination light from the white LED is projected; a movement device which moves the cup set in an arm toward the lens along a reference axis for cup attachment, the position of the reference axis being associated with the alignment mark; and a light intensity increasing and decreasing device which increases and decreases light intensity of the white LED in response to an operation signal from an operation member to be operated by an operator, the operation member being placed on a front of a housing of the apparatus.
US08506351B2 Eyeglass lens processing apparatus
An eyeglass lens processing apparatus includes: a processing chamber; a pair of lens chuck shafts which chucks an eyeglass lens; a lens rotating unit including a motor for rotating the lens chuck shafts; a processing tool which processes a periphery of the lens; an axis-to-axis distance changing unit for changing an axis-to-axis distance between a rotating shaft attached to the processing tool and the lens chuck shafts; a data input unit for inputting processing condition data including a target lens shape; a processing controller which controls the lens rotating unit and the axis-to-axis changing unit to process the lens based on the input processing condition data a camera which is disposed in the processing chamber and takes a video picture of the processing of the lens; and a memory which stores video pictures and the processing condition data.
US08506350B1 Breast shaping and lifting support garment
A breast support garment. The garment comprises a right fabric panel for overlying the woman's right breast when worn, a left fabric panel for overlying the woman's left breast when worn, the right and the left panels having a relatively flat configuration when the garment is not worn, a first variable-length material strip attached to the right panel beginning at a region between the breasts and extending along a lower region of the right breast when the support garment is worn, a second variable-length material strip attached to the left panel beginning at the region between the breasts and extending along a lower region of the left breast when the garment is worn and the first and second material strips expanding when the garment is worn to allow the wearer's breasts to be received within cups formed in the right and left panels and further for providing lifting and upwardly directed forces on the right and left breasts as the first and second material strips attempt to return to their relaxed state.
US08506346B2 Automobile toy
An automobile toy, including, a front wheel chassis for supporting a front wheel axle, and a rear wheel chassis for supporting a rear wheel axle, the rear wheel chassis including, two arms extending forward, an end portion of each of the two arms being coupled to the front wheel chassis with the two arms separated from each other in a vehicle width direction of the automobile toy.
US08506345B2 Doll and hat with interchangeable features
A doll is disclosed. The doll has an outer layer that is constructed of a faux fur and that includes a number of openings. The faux fur has a pile height sufficient to at least partially conceal the openings. A number of interchangeable features can be connected to the outer layer by securing connecting members in the openings. Depending on the embodiment, the openings may be buttonholes or grommeted openings, and the connecting members may be buttons or connecting bars. Some embodiments of the doll may have a removable stuffed insert. When embodiments of the doll are not stuffed, or when the removable insert is removed, the doll may serve as a puppet, a hat, or a cover for an object.
US08506342B2 High brightness excimer lamp
A high brightness excimer light source has an elongated tube containing an excimer-forming gas and electrodes for exciting the gas to form a plasma, and thus create excimers such as a rare gas halogen excimer or a rare gas excimer. Light emitted from the excimer propagating axially along the tube passes out of the tube through an exit device such as a lens or optical fiber at one or both ends of the tube.
US08506341B2 Method of manufacturing sparkplugs
A method of manufacturing a spark plug having an insulator, a center electrode, a metallic shell, a ground electrode, and a noble metal tip provided on the ground electrode and having a discharge surface forming a spark discharge gap in cooperation with the center electrode. The method of manufacturing includes a fusion-zone formation step of forming a fusion zone through radiation of a high-energy beam to the boundary between the ground electrode and the noble metal tip.