最新美国发明专利
Document Document Title
US08426621B2 Refined edible oil having high beneficial constituents and methods for refining thereof
Methods for producing refined rice bran oil that include caustic treatment step(s) in an amount that is less than or equal to a theoretical amount of caustic required to neutralize practically all of the free fatty acids in the rice bran oil, but avoiding addition of excess caustic. An objective is to retain a high level of oryzanol in the refined oil.
US08426609B2 Polymers functionalized with imide compounds containing a protected amino group
A method for preparing a functionalized polymer, the method comprising the steps of preparing a reactive polymer and reacting the reactive polymer with an imide compound containing a protected amino group.
US08426607B2 Substituted amino-benzimidazoles, medicaments comprimising said compound, their use and their method of manufacture
The present invention relates to substituted amino-benzimidazoles of general formula (1) wherein the groups R1 to R14 and A, are defined as in the specification and claims and the use thereof for the treatment of Alzheimer's disease (AD) and similar diseases.
US08426606B2 2′,2-bisthiazole non-nucleoside compounds, preparation methods, pharmaceutical compositions and uses as hepatitis virus inhibitors thereof
The present disclosure belongs to the field of pharmaceutical chemistry, and relates to a class of 2′,2-bisthiazole non-nucleoside compounds of following formula I, the preparation method and the pharmaceutical composition thereof. The compounds have both the anti-HBV and anti-HCV activities and are useful in treating hepatitides B and C. Pharmacokinetic tests showed the compounds have good bioavailability.
US08426604B2 Aminothiazolones as estrogen related receptor-alpha modulators
The present invention relates to compounds of Formula (I), methods for preparing these compounds, compositions, intermediates and derivatives thereof and for treating a condition including but not limited to ankylosing spondylitis, artherosclerosis, arthritis (such as rheumatoid arthritis, infectious arthritis, childhood arthritis, psoriatic arthritis, reactive arthritis), bone-related diseases (including those related to bone formation), breast cancer (including those unresponsive to anti-estrogen therapy), cardiovascular disorders, cartilage-related disease (such as cartilage injury/loss, cartilage degeneration, and those related to cartilage formation), chondrodysplasia, chondrosarcoma, chronic back injury, chronic bronchitis, chronic inflammatory airway disease, chronic obstructive pulmonary disease, diabetes, disorders of energy homeostasis, gout, pseudogout, lipid disorders, metabolic syndrome, multiple myeloma, obesity, osteoarthritis, osteogenesis imperfecta, osteolytic bone metastasis, osteomalacia, osteoporosis, Paget's disease, periodontal disease, polymyalgia rheumatica, Reiter's syndrome, repetitive stress injury, hyperglycemia, elevated blood glucose level, and insulin resistance.
US08426601B2 Process for making organic compounds and the organic compounds made therefrom
A compound of formula II is prepared by: reacting a compound of formula F with 1-chloro-3,5-dibromobenzene to form a compound of formula G; reacting the compound of formula G with pinacol diborane to form a compound of formula H; reacting the compound of formula H with 1-bromo-3-iodobenzene to form a compound of formula J.
US08426600B2 Method for preparing montelukast sodium salts
Disclosed is a method for preparing a montelukast sodium salt of Formula 1. The method includes coupling a methanesulfonyl compound of Formula 2 below with a compound of Formula 3 below in the presence of a bistrimethylsilylamide alkali metal salt, further adding an alkali metal base thereto and hydrolyzing the mixture by heating to prepare a compound of Formula 4 below, reacting the compound of Formula 4 with 4-tert-butylcyclohexylamine, followed by purification, to prepare an amine salt of Formula 5, and converting the amine salt of Formula 5 into a sodium salt.
US08426598B2 N-heterocyclic M1 receptor positive allosteric modulators
The present invention is directed to compounds of formula (I) (I) which are M1 receptor positive allosteric modulators and that are useful in the treatment of diseases in which the M1 receptor is involved, such as Alzheimer's disease, schizophrenia, pain or sleep disorders. The invention is also directed to pharmaceutical compositions comprising the compounds, and to the use of the compounds and compositions in the treatment of diseases mediated by the M1 receptor.
US08426596B2 Process of producing bleach boosters
This invention relates to a process of producing compounds, which are useful as bleach boosters, as well as to the compounds, which are obtainable using said process, and to their use.
US08426591B2 2-(substituted phenyl)-6-amino-5-alkoxy, thioalkoxy and aminoalkyl-4-pyrimidinecarboxylates and their use as herbicides
2-(Substituted phenyl)-6-amino-5-alkoxy, thioalkoxy and aminoalkyl-4-pyrimidinecarboxylic acid and its derivatives are potent herbicides demonstrating broad spectrum of weed control.
US08426588B2 Phenylalanine derivatives
Specified phenylalanine derivatives and analogues thereof have an antagonistic activity to α4 integrin. They are used as therapeutic agents for various diseases concerning α4 integrin.
US08426582B1 Processes for preparing certain hexaazaisowurtzitanes and their use in preparing hexanitrohexaazaisowurtzitane
A heavy-metal-free sequence leading to a superior, more economical, and scalable process for the high efficiency conversion of hexaallylhexaazaisowurtzitane (HAllylIW) to hexanitrohexaazaisowurtzitane (CL-20).
US08426581B2 RNA interference mediated inhibition of the FCεR1α gene
The present invention relates to compounds, compositions, and methods for the study, diagnosis, and treatment of traits, diseases and conditions that respond to the modulation of FCεR1α gene expression and/or activity, and/or modulate a FCεR1α gene expression pathway. Specifically, the invention relates to doublestranded nucleic acid molecules including small nucleic acid molecules, such as short interfering nucleic acid (siNA), short interfering RNA (siRNA), double-stranded RNA (dsRNA), micro-RNA (miRNA), and short hairpin RNA (shRNA) molecules that are capable of mediating or that mediate RNA interference (RNAi) against FCεR1α gene expression.
US08426579B2 SiRNA targeting myeloid differentiation primary response gene (88) (MYD88)
Efficient sequence specific gene silencing is possible through the use of siRNA technology. By selecting particular siRNAs by rational design, one can maximize the generation of an effective gene silencing reagent, as well as methods for silencing genes. Methods, compositions, and kits generated through rational design of siRNAs are disclosed including those directed to nucleotide sequences for MYD88.
US08426576B2 Arabidopsis derived promoters for regulation of plant expression
The instant invention is directed to a constitutive promoter for use in plants. The plant genus from which the promoter is derived is Arabidopsis. The invention encompasses the isolated promoter, expression cassettes comprising said promoter and a heterologous nucleic acid segment, and monocot and dicot plants and plant cells transformed with said expression cassettes.
US08426574B2 Identification of astrovirus VA1 associated with gastroenteritis in humans
Provided herein is a novel human astrovirus, its nucleic acid sequence, as well as methods to detect and diagnose the presence of the astrovirus.
US08426568B2 Rhamnose substituents of SL0101 and therapeutic uses thereof
The present invention provides compositions and methods useful for preparing and using analogs, derivatives, and modifications of kaempferols that have anti-neoplastic activity. More specifically, the compounds are analogs, derivatives, and modifications of SLO1O1. The invention further provides compounds that are inhibitors of rsk activity. The invention further provides compounds that selectively inhibit excessive rsk activity in cancers. The present invention further provides methods for treating cancer using compounds of the invention.
US08426563B2 Antibody specific for B7-H5, a costimulatory polypeptide
B7-HS costimulatory polypeptides, nucleic acids encoding such polypeptides, and methods for using the polypeptides and nucleic acids to enhance a T cell response are provided herein.
US08426562B2 Methods and compositions for modulating tumor cell activity
Antibodies which target clusterin, a protein involved in the epithelial-to-mesenchymal transition of carcinoma cells, are identified and characterized. The antibodies may be used to modulate tumor cell activity through binding the clusterin.
US08426557B2 IGF-1R binding polypeptides and their use
This invention relates to polypeptides which bind to IGF-1R and to applications of those polypeptides in medicine, veterinary medicine, diagnostics and imaging.
US08426555B2 Acute leukemia and lymphoblastic lymphona-specific CD43 epitope
The present invention relates to a CD43 epitope expressed on human acute leukemia and lymphoblastic lymphoma cells and its use. More particularly, the present invention relates to a CD43 epitope expressed on human acute leukemia, lymphoblastic lymphoma cells, but not on mature hematopoietic cells, hematopoietic stem cells and non-hematopoietic cells, and to its diagnostic and therapeutic application on acute leukemia and lymphoblastic lymphoma.
US08426553B2 Method for removing diluent from a polymer extrudate, and its applications
A method for removing a process solvent (P-sol) from a polymer extrudate, especially in connection with a process for producing a microporous membrane. The method involves contacting the extrudate with chlorinated hydrocarbon (CHC) and hydrofluoroether (HFE) in a first stage; contacting the extrudate from the first stage with HFE in a second stage; combining the first and second waste streams and then separating the P-sol from the combined streams to make an HFE-CHC stream; cooling the HFE-CHC stream to make an HFE-rich phase and a CHC-rich phase; and conducting the CHC-rich phase and/or the HFE-rich phase to step (A).
US08426543B2 Adhesive composition and adhesive film
An adhesive composition of the present invention includes, as a main component, a polymer produced by copolymerization of a monomer composition including: styrene; a (meth)acrylic acid alkyl ester having a chain structure; a (meth)acrylic acid ester having an aliphatic ring; and a (meth)acrylic acid ester having an aromatic ring, wherein: the styrene is contained in a range of 40 to 69 parts by mass; the (meth)acrylic acid alkyl ester having the chain structure is contained in a range of 20 to 30 parts by mass; the (meth)acrylic acid ester having the aliphatic ring is contained in a range of 10 to 25 parts by mass; and the (meth)acrylic acid ester having the aromatic ring is contained in a range of 1 to 5 parts by mass, where the total amount of the above components is 100 parts by mass. This allows for provision of an adhesive composition having high adhesive strength under high-temperature environment, as well as high heat resistance, high alkali resistance, and easiness in stripping from semiconductor wafers and the like even after high-temperature processing.
US08426531B2 Method for monitoring monomer concentration in interfacial polycarbonate manufacturing process
The present invention relates to an improved process for online measurement of monomer concentration, specifically bisphenol A, in an interfacial polycarbonate manufacturing process. Wherein the measurement is obtained by vibrational spectroscopy for the purpose of improving process control, specifically, controlling the carbonate polymer molecular weight.
US08426527B2 Crosslinkable fluororubber composition and crosslinked rubber article
Obtaining a crosslinked rubber with high flexibility at low temperature includes crosslinking a fluororubber composition. The fluororubber composition includes a fluororubber and a compound of formula (X—)x(Z—)zY. In the formula, X is U—(CF2)aO(CF2CF2O)b—; Z is RFO(CF2CF2O)c—; Y is a (x+z) valent perfluoro saturated hydrocarbon group, optionally interrupted by an etheric oxygen atom; x is an integer of at least 3; z is an integer of at least 0; U is a monovalent group with an unsaturated hydrocarbon, a bromine atom, an iodine atom, or a combination thereof; RF is a C1-20 linear perfluoroalkyl group, optionally interrupted by an etheric oxygen atom; a is an integer of from 0 to 20; b is an integer of from 1 to 200; and c is an integer of from 3 to 200.
US08426522B2 Copolymer rubber composition, rubber foamed product, and automotive sealant
The copolymer rubber composition comprises 60 to 75% by weight of a copolymer rubber (1) and 40 to 25% by weight of a copolymer rubber (2), and [iodine value of the copolymer rubber (1)−iodine value of the copolymer rubber (2)] is 5 to 30. The copolymer rubber (1) is an ethylene-α-olefin-nonconjugated polyene copolymer rubber having an ethylene unit of 50 mol % to 70 mol %, an α-olefin unit of 50 mol % to 30 mol %, and an iodine value of 15 to 45, and the copolymer rubber (2) is an ethylene-α-olefinic copolymer rubber having an ethylene unit of more than 70 mol % and 95 mol % or less, an α-olefin unit of less than 30 mol % and 5 mol % or more, and an iodine value of 10 to 30.
US08426520B2 Heterophasic polypropylene with high impact properties
The present invention relates to a heterophasic polypropylene resin comprising a polypropylene homo- or copolymer matrix phase (A) and an ethylene-propylene copolymer phase (B) dispersed within the matrix, wherein the heterophasic polypropylene resin has a fraction insoluble in p-xylene (XCU) at 25° C. with an intrinsic viscosity of 2.0 dl/g or less, determined according to DIN EN ISO 1628-1 and -3, and a fraction soluble in p-xylene (XCS) at 25° C. having an intrinsic viscosity of 2.0 to 4.5 dl/g, determined according to DIN EN ISO 1628-1 and -3, and an amount of ethylene monomer units of 60 to 85 mol %, a heterophasic polypropylene composition comprising such a resin, a process for preparing that resin, and an article made thereof.
US08426519B2 Silicone-thermoplastic polymer reactive blends and copolymer products
Silicone-thermoplastic polymer reactive blends and copolymer products are prepared using economical post-reactor reactive mixing, e.g., extrusion. The procedure is based on the ring-opening polymerization of cyclic siloxanes within a thermoplastic polymer matrix. In a preferred mode, the thermoplastic polymer is a polyolefin, optionally containing silane groups that are available for reaction with the silicone polymer that is formed in situ. The resulting materials provide hybrid performance that can extend the range of applications beyond those which are served by thermoplastic polymers or silicones alone, or their physical blends.
US08426516B2 Polymer compound having aroylbiphenylene skeleton and thermocurable film forming polymer composition
There is provided a polymer compound having excellent transparency and excellent heat resistance, a high refractive index, an excellent solubility in various solvents, and a low viscosity and excellent handling properties when the polymer compound is dissolved in a solvent; and a production method of the polymer compound; and a polymer composition containing the polymer compound. And there is also included an aroylbiphenyl compound of Formula (1): [in Formula (1), X is a halogen atom, and R1 is a hydrogen atom or a group of Formula (2a) or Formula (2b); and in Formula (2a) and Formula (2b), R2 and R3 are independently a hydrogen atom or a C1-6 alkyl group]; a polymer compound obtained by using the aroylbiphenyl compound; and a thermocurable film forming polymer composition comprising: as a component (A), the polymer compound, and as a component (B), a crosslinkable compound.
US08426514B2 Acrylic based pressure sensitive adhesive formulation
An adhesive formulation is disclosed that includes (a) a pre-polymerized cross-linkable non-water soluble acrylic based pressure sensitive adhesive, (b) a cross-linking agent selected from the group consisting of metal chelates, silanes, epoxy-functional compounds, aziridine compounds, multifunctional amines, alkyl halide compounds, multifunctional acids, multifunctional mercaptans, multifunctional epoxy compounds, polyols in the presence of a catalyst, and combinations thereof and (c) a polyol having a weight average molecular weight in the range from 1,000 g/mol to 10,000 g/mol. When cured, the adhesive formulation is self-wetting and has a peel strength less than 20 oz/in.
US08426513B2 Rubber composition and tire using the same
This invention provides a rubber composition having excellent workability, fracture characteristics and wear resistance and low heat buildup, which comprises not less than 20 parts by mass of a reinforcing filler (B) and 5 to 60 parts by mass of a modified aromatic vinyl compound-conjugated diene compound copolymer (C) having at least one functional group, an aromatic vinyl compound content of 5 to 80% by mass, a vinyl bond content in a conjugated diene compound portion of 10 to 80% by mass and a weight average molecular weight as measured through a gel permeation chromatography and converted to polystyrene of 5,000 to 500,000 based on 100 parts by mass of a rubber component (A) containing not less than 10% by mass of a modified conjugated diene-based polymer having at least one functional group.
US08426512B2 Rubber composition containing silica reinforcement and functionalized polybutadiene rubber and tires having a component thereof
This invention relates to a silica reinforcement-containing rubber composition which contains a functionalized polybutadiene rubber to promote a relatively low hysteretic loss to thereby enhance its desirability for tire sidewall and subtread applications in a sense of advantageously promoting reduced tire rolling resistance without significantly compromising various other desirable tire performance parameters.
US08426510B2 Melt spinning blends of UHMWPE and HDPE and fibers made therefrom
Compositions that are intimate blends of ultrahigh molecular weight polyethylene and high-density polyethylene (HDPE), and which are melt spinnable. The compositions include certain quasi-spherical particles. Also disclosed is a method of melt spinning from such compositions and the multi-filament fibers produced thereby. The fibers of the invention are useful in a variety of applications.
US08426501B1 Generation of polymer concretes incorporating carbon nanotubes
Exemplary embodiments provide materials and methods for forming CNTs-polymer composites (e.g., CNTs-SBR latex nano-composites and/or CNTs-epoxy nano-composites), CNTs-polymer concrete, and CNTs-polymer modified cementitious composites. In one embodiment, a plurality of CNTs and a surfactant-containing polymer, including a surfactant attached to a polymer chain, can be dispersed within a cementitious matrix to form a CNTs-polymer modified cementitious composite with the surfactant non-covalently bonded to one or more CNTs.
US08426500B2 Cathodic electrodeposition paint containing a vinylpyrrolidone copolymer
An aqueous coating composition comprising (A) at least one water-dispersible organic binder containing cationic groups and (B) 0.05%-10% by weight, based on the solids content of the aqueous coating composition, of a water-thinnable vinylpyrrolidone copolymer, where the vinylpyrrolidone copolymer (B) contains vinylpyrrolidone monomer units and vinyl acetate monomer units in a molar ratio of 0.3:0.7 to 0.7:0.3, preferably of 0.4:0.6 to 0.6:0.4 and possesses a weight-average molecular weight of less than 200 000 g/mol.
US08426499B2 Offset printing ink
An offset printing ink in which a modified pigment (D) is dispersed in a vehicle as a colorant, the modified pigment (D) contains a polymer (P) on the surface thereof, and the polymer (P) is obtained by polymerizing a resin or fat (B) which has a polymerizable unsaturated group, and is soluble in a nonaqueous solvent, and at least one of polymerizable unsaturated monomers (C) which are soluble in a nonaqueous solvent and insoluble or poorly-soluble after polymerization, and specifically, the resin or fat (B) is selected from the group consisting of acrylic resins having a polymerizable unsaturated group, alkyd resins which are soluble in the nonaqueous solvent, natural resin-modified phenol resins, and fats.
US08426497B2 Synthesis of improved binders and modified tacticity
The invention relates to a process for preparing polymers for coating applications by polymerizing esters of acrylic acid or of methacrylic acid or vinyl aromatics or other free-radically polymerizable vinyl compounds or monomer mixtures composed predominantly of such monomers by means of a continuous polymerization process. In particular, the invention relates to a solvent-free preparation process for polymers, through which the binder can be prepared for coating applications with superior processing properties, very good thermal stability, improved pigment wetting and a higher gloss.
US08426487B2 Fluorine-based compounds and coating compositions comprising the same
The present invention provides a fluorine-based compound and a coating composition and a film including the same. By using the fluorine-based compound according to the present invention, a film having excellent functionalities of water repellency, oil repellency, weatherability and contamination resistance can be provided.
US08426486B2 Highly crystalline cross-linked oxidation-resistant polyethylene
The present invention relates to methods for making highly crystalline cross-linked polymeric material, for example, highly crystalline cross-linked ultra-high molecular weight polyethylene (UHMWPE). The invention also provides methods of making antioxidant-doped highly crystalline cross-linked polymeric material using high pressure and high temperature crystallization processes, medical implants made thereof, and materials used therein.
US08426483B2 Metal compounds for use as initiators
The present invention relates to initiators of the general formula {[M(L)a]Xb}n, wherein said initiators preferably have (SbF6−) as a counterion and are obtainable by a complexing reaction of a corresponding metal-SbF6 salt with a corresponding ligand (L). The present invention further relates to preparations and epoxy resin systems that contain such initiators and, in particular, are non-thermally and/or thermally curable.
US08426478B2 Defoamer formulation
Formulation comprising hydrophobicized particles of silicon dioxide, mineral oil and one or more emulsifiers, where the hydrophobicized silicon dioxide is a fumed silicon dioxide, possesses a BET surface area of 200 to 300 m2/g, has on the surface of the particles O—Si—(CnH2n+1)3 groups, where n is 1 to 3 and where the (CnH2n+1) units are alike or different, has a carbon content of 1.5% to 5% by weight, based on the hydrophobic silicon dioxide, and is present in the formulation with a fraction of 0.05% to 5% by weight.
US08426477B1 Polymeric micelles for drug delivery
The present invention relates to the field of polymer chemistry and more particularly to multiblock copolymers and micelles comprising the same.
US08426476B2 Biobeneficial coating compositions and methods of making and using thereof
A biobeneficial coating composition for coating an implantable device, such as a drug eluting stent, a method of coating the device with the composition, and an implantable device coated with the composition are provided.
US08426475B2 Treatment of connective tissue diseases of the skin
The present invention provides effective and safe medicaments for the treatment of connective tissue diseases of the skin, particularly with respect to the treatment of cutaneous forms of Lupus Erythematous. The medicaments comprise as the therapeutically active ingredient a beta2 adrenoceptor agonist. The invention furthermore relates to dermatological compositions without skin sensitization properties and which contain enantiomerically pure or enriched R-enantiomers of a beta2 adrenoceptor agonist.
US08426471B1 Methods and compositions for reducing body fat and adipocytes
Provided are methods of reducing body fat in a subject, comprising locally (e.g., topically) administering one or more compounds of the Formula (I): or a pharmaceutically acceptable salt, hydrate, solvate, stereoisomer, polymorph, tautomer, isotopically enriched derivative, or prodrug thereof, wherein X is —OR1, —SR2, or —NR3R4, and R1, R2, R3, and R4 are as defined herein.
US08426468B2 Use of medium chain triglycerides for the treatment and prevention of alzheimer'S disease and other diseases resulting from reduced neuronal metabolism
Methods and compositions for treating or preventing, the occurrence of senile dementia of the Alzheimer's type, or other conditions arising from reduced neuronal metabolism and leading to lessened cognitive function are described. In a preferred embodiment the administration of triglycerides or fatty acids with chain lengths between 5 and 12, to said patient at a level to produce an improvement in cognitive ability.
US08426465B2 Substituted acylanilides and methods of use thereof
This invention provides SARM compounds and uses thereof in treating a variety of diseases or conditions in a subject, including, inter alia, a muscle wasting disease and/or disorder or a bone-related disease and/or disorder.
US08426458B2 Hepatitis C Virus inhibitors
The present invention discloses compounds of Formula (I), or pharmaceutically acceptable salts, esters, or prodrugs thereof: which inhibit RNA-containing virus, particularly the hepatitis C virus (HCV). Consequently, the compounds of the present invention interfere with the life cycle of the hepatitis C virus and are also useful as antiviral agents. The present invention further relates to pharmaceutical compositions comprising the aforementioned compounds for administration to a subject suffering from HCV infection. The invention also relates to methods of treating an HCV infection in a subject by administering a pharmaceutical composition comprising the compounds of the present invention.
US08426457B2 Methods of improving skin quality
Methods of improving skin quality are disclosed. Generally, the methods include topically administering an IRM compound to a treatment area of skin for a period of time and in an amount effective for improving the quality of the skin. Suitable IRM compound compounds include agonists of one or more TLRs.
US08426456B2 Fungicidal control of moulds
A composition for treating fungus infection of turfgrass, such as snow mold infection, comprises a mixture of fungicidally effective amounts of formulae 1 and 2: and in particular mixtures of iprodione and trifloxystrobin. A method for treating snow molds comprises applying the mixture before the onset of continuous snow cover, in at least one application.
US08426453B2 Treatment of a stomach or small intestine ulcer with 2-(3-cyano-4-isobutyloxyphenyl)-4-methyl-1,3-thiazole-5-carboxylic acid
Administration of 2-(3-cyano-4-isobutyloxyphenyl)-4-methyl-1,3-thiazole-5-carboxylic acid is effective for treating a stomach or small intestine ulcer.
US08426451B2 Oral solid preparation and method of manufacturing the same
An oral solid preparation including a base compound and a powdery or granular additive colored with a colorant and a method of manufacturing an oral solid preparation including the steps of: coloring an additive with a colorant, mixing the resultant additive with a base compound, and tableting the mixture.
US08426450B1 Substituted 4-phenyl pyridines having anti-emetic effect
Disclosed are compounds, compositions and methods for the prevention and/or treatment of diseases which are pathophysiologically mediated by the neurokinin (NK1) receptor. The compounds have the general formula (I):
US08426449B2 Aminoalkylphenyl antagonists of prostaglandin D2 receptors
Described herein are compounds that are antagonists of PGD2 receptors. Also described are pharmaceutical compositions and medicaments that include the compounds described herein that are antagonists of PGD2 receptors. Also described herein are methods of using such antagonists of PGD2 receptors, alone and in combination with other compounds, for treating respiratory, cardiovascular, and other PGD2-dependent or PGD2-mediated conditions or diseases.
US08426448B2 1,5-diphenyl-pyrrolidin-2-one compounds as CB-1 ligands
CB-1 receptor inverse agonist compounds of Formula and pharmaceutical compositions for the treatment of obesity or cognitive impairment associated with schizophrenia.
US08426444B2 Oxabicycloheptanes and oxabicycloheptenes, their preparation and use
This invention provides compounds having the structure which may be used for the treatment of tumors.
US08426443B2 Compounds which have activity at M1 receptor and their uses in medicine
Compounds of formula (I) or a salt thereof are provided: wherein R4, R5, R6, Q, A, Y and R are as defined in the description. Uses of the compounds as medicaments and in the manufacture of medicaments for treating psychotic disorders, cognitive impairments and Alzheimer's Disease are disclosed. The invention further discloses pharmaceutical compositions comprising the compounds.
US08426442B2 Compounds
A compound of formula (I): Or its salts or pharmaceutically acceptable derivatives thereof wherein: A represents a chemical moiety with the general formula (II): X and Y are independently selected from a group consisting of CH2, CH(R5) or C(R5)(R6); R1 is selected from the group consisting of optionally substituted arylalkyl, and optionally substituted heteroarylalkyl; R2 is selected from the group consisting of optionally substituted aryl or optionally substituted heteroaryl or NR7R8; R3 R4 R5 R6 R7 and R8 are as defined herein, n=0, 1, 2 or 3; o=0, 1 or 2, with the proviso that when o=0, then n is 1, 2 or 3 and when o=1, then n is 1 or 2 is provided. Pharmaceutical compositions comprising the compounds are also provided. These compounds are useful in the treatment of various disorders including arrhythmia.
US08426441B2 Inhibitors of bruton's tyrosine kinase
This application discloses novel imidazo[1,2-a]pyridine and imidazo[1,2-b]pyridazine derivatives according to Formulae I-VI: wherein R, R′, R″, Q, X, and Y are defined as described herein, which inhibit Btk. The compounds disclosed herein are useful to modulate the activity of Btk and treat diseases associated with excessive Btk activity. The compounds are further useful to treat inflammatory and auto immune diseases associated with aberrant B-cell proliferation such as rheumatoid arthritis. Also disclosed are compositions containing compounds of Formulae I-VI and at least one carrier, diluent or excipient.
US08426439B2 Compositions and methods for prophylaxis and treatment of addictions
The present invention relates to methods of treating or preventing addiction and relapse use of addictive agents, and treating or preventing addictive or compulsive behavior and relapse practice of an addictive behavior or compulsion, by administering a peroxisome proliferator-activated receptor gamma (PPARγ) agonist, alone or in combination with another therapeutic agent, such as, for example, an opioid receptor antagonist or an antidepressant. The present invention also includes pharmaceutical compositions for treating or preventing addiction or relapse that include a PPARγ agonist and one or more other therapeutic agents, as well as unit dosage forms of such pharmaceutical compositions, which contain a dosage effective in treating or preventing addiction or relapse. The methods and compositions of the invention are useful in the treatment or prevention of addiction to any agent, including alcohol, nicotine, marijuana, cocaine, and amphetamines, as well as compulsive and addictive behaviors, including pathological gambling and pathological overeating.
US08426436B2 Heterocyclic cyclopamine analogs and methods of use thereof
The present invention relates to steroidal alkaloids that can be used in the treatment of hedgehog pathway related disorders, particularly cancer.
US08426433B2 Anticoagulant compounds, pharmaceutical compositions on their basis to treat thrombotic conditions, and plasma-substituting solution to correct hypercoagulation defects of hemodilution
This invention relates to new chemical compounds, application of these compounds as anticoagulants, pharmaceutical compositions, and plasma-substituting solutions on their basis, and can be used for treating thromboembolic complications of diseases such as myocardial infarction, stroke, and thrombosis of deep veins or a pulmonary artery; and for preventing hypercoagulation conditions in consequence of injuries, surgeries, sepsis, various obstetric pathologies, in disaster medicine, resuscitation, and so on.
US08426432B2 Inhibitors of dihydrofolate reductase with antibacterial antiprotozoal, antifungal and anticancer properties
The compositions and methods described herein discloses the design, synthesis and testing of compounds that act as inhibitors of DHFR. The basic scaffold of these inhibitors includes a 2,4-diaminopyrimidine ring with a propargyl linker to another substituted aryl, bicyclo or heteroaryl ring. These DHFR inhibitors are potent and selective for many different pathogenic organisms, including the DHFR enzyme from bacteria such as Bacillus anthracis and methicillin-resistant Staphylococcus aureus, fungi such as Candida glabrata, Candida albicans and Cryptococcus neoformans and protozoa such as Cryptosporidium hominis and Toxoplasma gondii. These compounds and other similar compounds are also potent against the mammalian enzyme and may be useful as anti-cancer therapeutics.
US08426429B2 2-amino-quinazoline derivatives useful as inhibitors of β-secretase (BACE)
The present invention is directed to novel 2-amino-3,4-dihydro-quinazoline derivatives, pharmaceutical compositions containing them and their use in the treatment of Alzheimer's disease (AD) and related disorders. The compounds of the invention are inhibitors of β-secretase, also known as β-site cleaving enzyme and BACE.
US08426428B2 EGFR kinase knockdown via electrophilically enhanced inhibitors
Provided herein are electrophilically enhanced kinase inhibitors of Formula I. Also provided herein are methods of making and utilizing the same.
US08426427B2 Fused heterocyclic derivative, pharmaceutical composition comprising the derivative, and use of the composition for medical purposes
The present invention provides compounds useful as agents for the prevention or treatment of a sex hormone-dependent disease or the like. That is, the present invention provides fused heterocyclic derivatives represented by the following general formula (I) which has a GnRH antagonistic activity, pharmaceutical compositions containing the same, medicinal uses thereof and the like. In the formula (I), rings A is 5-membered cyclic unsaturated hydrocarbon or 5-membered heteroaryl; RA is halogen, alkyl, alkenyl, alkynyl, carboxy, alkoxy, carbamoyl, alkylcarbamoyl, etc.; ring B is aryl or heteroaryl; RB is halogen, alkyl, carboxy, alkoxy, carbamoyl, alkylcarbamoyl, etc.; E1 and E2 are oxygen atom, etc.; Q is hydrogen atom, alkyl, alkylsulfonyl, acyl, etc.; X is -(alkylene)-Z, —CO—Y, —SO2—Y, etc. (in which Y is Z or amino, etc.; Z is cycloalkyl, heterocycloalkyl, aryl, heteroaryl, etc.
US08426420B2 Heterocyclic pyrazole-carboxamidesas P2Y12 antagonists
The present invention relates to compounds of the formula I, wherein R1; R2; Z; A; B; D; Q; J; V; G and M have the meanings indicated in the claims. The compounds of the formula I are valuable pharmacologically active compounds. They exhibit a strong anti-aggregating effect on platelets and thus an anti-thrombotic effect and are suitable, e.g., for the therapy and prophylaxis of cardio-vascular disorders like thromboembolic diseases or restenoses. They are reversible antagonists of the platelet ADP receptor P2Y12, and can in general be applied in conditions in which an undesired activation of the platelet ADP receptor P2Y12 is present or for the cure or prevention of which an inhibition of the platelet ADP receptor P2Y12 is intended. The invention furthermore relates to processes for the preparation of compounds of the formula I, their use, in particular as active ingredients in pharmaceuticals, and pharmaceutical preparations comprising them.
US08426418B2 Method to treat melanoma in BRAF inhibitor-resistant subjects
Methods to treat cancer patients, especially melanoma patients, who have BRAF mutations and have become resistant to BRAF mutant kinase inhibitors employ inhibitors of multiple receptor tyrosine kinases. In addition, methods are described for identifying pharmaceutical compositions and drugs that will be successful in treating these patients.
US08426415B2 Human ADAM-10 inhibitors
Magnesium salts/complexes of compounds useful for inhibiting the ADAM-IO protein and methods of making and purifying them are provided. Further provided are compositions comprising magnesium salts/complexes of the compounds in combination with a pharmaceutically acceptable carrier. The compounds well as such compositions comprising them are useful for the treatment of cancer, arthritis, diseases related to angiogenesis, such as renal diseases, heart diseases, such as heart failure, atherosclerosis, and stroke, inflammation, ulcer, infertility, scleroderma, endometriosis, mesothelioma, and diabetes. In addition, methods of treating forms of cancer, arthritis, and diseases related to angiogenesis in which ADAM-10 plays a critical role are provided.
US08426412B2 2-alkynyl-6-pyridin-2-yl-pyridazinones, 2-alkynyl-6-pyridin-2-yl-dihydropyridazinones, 2-alkynyl-6-pyrimidin-2-yl-pyridazinones and 2-alkynyl-6-pyrimidin-2-yl-dihydropyridazinones and their use as fungicides
This invention relates to certain novel 2-alkynyl-6-pyridin-2-yl-pyridazinones, 2-alkynyl-6-pyridin-2-yl-dihydropyridazinones, 2-alkynyl-6-pyrimidin-2-yl-pyridazinones and 2-alkynyl-6-pyrimidin-2-yl-dihydropyridazinones such as those illustrated in Formula I and to the use of these compounds for control of fungal pathogens of plants and mammals.
US08426410B2 Compounds, formulations, and methods for treating or preventing inflammatory skin disorders
In methods, compounds, and topical formulations for treatment of inflammatory skin disorders incorporating compounds represented by the formulas below: wherein each of R1, R2, and R3 is independently hydrogen, hologen, alkyl, or alkoxy; each of R4 and R5 is independently hydrogen, alkyl, or alkoxy; and each of R6 and R7 is independently hydrogen, nitro, alkyl, or alkoxy; wherein each of A1, A3, and A4 is independently hydrogen or alkyl; and A2 is independently hydrogen or hydroxy; and wherein each of B1, B2, and B3 is independently hydrogen, hydroxy, or alkoxy; and each of B4 and B5 is independently hydrogen or alkyl, applying such compounds topically as sprays, mists, aerosols, solutions, lotions, gels, creams, ointments, pastes, unguents, emulsions, and suspensions to treat inflammatory skin disorders and the symptoms associated therewith.
US08426409B2 Inhibitors of Bruton's tyrosine kinase
This application discloses 6-Phenyl-imidazo[1,2-a]pyrazine derivatives according to generic Formulae I-V: wherein, variables Q, R, Y1, Y2, Y3, Y4, n, and m are defined as described herein, which inhibit Btk. The compounds disclosed herein are useful to modulate the activity of Btk and treat diseases associated with excessive Btk activity. The compounds are further useful to treat inflammatory and auto immune diseases associated with aberrant B-cell proliferation such as rheumatoid arthritis. Also disclosed are compositions comprising compounds of Formulae I-V and at least one carrier, diluent or excipient.
US08426407B2 Preparation of 1-(substituted aryl)-5-trifluoromethyl-2-(1H)pyridone compounds and salts thereof and their applications
A 1-(substituted aryl)-5-trifluoromethyl-2-(1H)pyridone compounds and pharmaceutical acceptable salts, preparation methods and uses for preparing the drugs for treating fibrosis thereof.
US08426400B2 β-lactamyl phenylalanine, cysteine, and serine vasopressin antagonists
Substituted 2-(azetidin-2-on-1-yl)alkoxyalkylalkanoic acids and 2-(azetidin-2-on-1-yl)arylalkylalkanoic acids, and analogs and derivatives thereof are described. Methods for using the described compounds, and pharmaceutical compositions thereof, to treat disease states responsive to antagonism of one or more vasopressin receptors are also described.
US08426398B2 Conjugates of noscapine and folic acid and their use in treating cancer
The present invention is directed to compounds which are conjugates of two non-toxic natural products, noscapine (and various noscapine analogs) and folic acid (and various folic acid analogs), where the folic acid is conjugated to noscapine or the noscapine analog at the 9-position on the isoquinoline ring on the noscapine framework. Pharmaceutical compositions including the compounds, and methods of treating various tumors using the compounds and compositions, are also disclosed. The conjugates are particularly useful for treating cancers which overexpress the Folate Receptor α (FRa) receptor.
US08426396B2 Treatment for achondroplasia
The present application provides, inter alia, methods of treating disorders mediated by FGFRs and methods of screening for Hsp90 inhibitor compounds.
US08426390B2 Triazene compounds for the treatment of cancer
The present invention relates to novel triazene compounds, to a process for their preparation, to pharmaceutical compositions comprising them, and to the use thereof in the treatment of cancer diseases in humans. The novel triazene compounds are distinguished, as compared with the known triazene compounds, by improved activity while at the same time having reduced toxicity, that is to say by fewer side-effects.
US08426389B2 Crystalline form of R)-3-(4-(2-(2-methyltetrazol-5-yl)pyridin-5-yl)-3-fluorophenyl)-5-hydroxymethyl oxazolidin-2-one dihydrogen phosphate
A crystalline form of crystalline (R)-3-(4-(2-(2-methyltetrazol-5-yl)-pyridin-5-yl)-3-fluorophenyl)-5-hydroxymethyl oxazolidin-2-one dihydrogen phosphate, methods of making the crystalline form and pharmaceutical compositions comprising the crystalline form are useful antibiotics. Further, the derivatives of the present invention may exert potent antibacterial activity versus various human and animal pathogens, including Gram-positive bacteria such as Staphylococi, Enterococci and Streptococi , anaerobic microorganisms such as Bacteroides and Clostridia, and acid-resistant microorganisms such as Mycobacterium tuberculosis and Mycobacterium avium. Accordingly, the compositions comprising the crystalline form may be used in antibiotics.
US08426388B2 Prodrugs of HIV protease inhibitors
A compound of the formula is disclosed as a prodrug of an HIV protease inhibitor. Methods and compositions for inhibiting HIV protease activity and treating HIV infection are also disclosed.
US08426386B2 NK1 receptor antagonist composition
An NK1 receptor antagonist composition of the present invention uses maltooligosaccharide having an NK1 receptor antagonistic activity as an active ingredient. A suitable amount of the maltooligosaccharide to be blended in the NK1 receptor antagonist composition of the present invention is 0.000001 to 70% by weight. The NK1 receptor antagonist composition of the present invention is prepared for use into various forms of external agents, internal medicines, foods and beverages by blending various materials as the ingredients other than the active ingredient. The NK1 receptor antagonist composition of the present invention has high safety for being used for pharmaceuticals and has satisfactory therapeutic effects.
US08426384B2 Wound-healing pharmaceutical compositions in the form of a sterile powder based on amino acids and sodium hyaluronate
This invention relates to wound-healing pharmaceutical compositions in the form of a sterile powder based on amino acids and sodium hyaluronate.
US08426383B2 Anti-aging composition for external use comprising low and high molecular weight hyaluronic acids and the polysaccharides extracted from root bark of Ulmus davidiana
Disclosed is an anti-aging composition for external use on skin, which includes low-molecular weight hyaluronic acids, high-molecular weight hyaluronic acids and polysaccharides extracted from root bark of Ulmus davidiana, as active ingredients. The composition including the low-molecular weight hyaluronic acids, high-molecular weight hyaluronic acids and polysaccharides extracted from root bark of Ulmus davidiana, in a predetermined ratio, shows significantly improved skin-moisturizing, skin elasticity-enhancing and inflammation-alleviating effects, as compared to a composition using one of the above ingredients alone. Therefore, the composition may be widely used as a pharmaceutical or cosmetic anti-aging composition.
US08426378B2 Oligomeric compounds comprising tricyclic nucelosides and methods for their use
The present disclosure provides tricyclic nucleosides, oligomeric compounds comprising at least one of the tricyclic nucleosides and methods of using the oligomeric compounds. The methods provided herein include contacting a cell or administering to an animal at least one of the oligomeric compounds. In certain embodiments, the oligomeric compounds hybridize to a portion of a target RNA resulting in loss of normal function of the target RNA.
US08426377B2 iRNA agents with biocleavable tethers
The invention relates to iRNA agents, which preferably include a monomer in which the ribose moiety has been replaced by a moiety other than ribose that further includes a tether having one or more linking groups, in which at least one of the linking groups is a cleavable linking group. The tether in turn can be connected to a selected moiety, e.g., a ligand, e.g., a targeting or delivery moiety, or a moiety which alters a physical property. The cleavable linking group is one which is sufficiently stable outside the cell such that it allows targeting of a therapeutically beneficial amount of an iRNA agent (e.g., a single stranded or double stranded iRNA agent), coupled by way of the cleavable linking group to a targeting agent—to targets cells, but which upon entry into a target cell is cleaved to release the iRNA agent from the targeting agent.
US08426368B2 Method of ameliorating oxidative stress and supplementing the diet
A method of supplementing a diet and ameliorating oxidative stress in a mammal includes administering a pharmaceutically effective amount of lipid soluble, hydrophobic active compounds having a chemical structure: wherein R1 is an aromatic backbone and R2 is a sulfur containing ligand. Through formation of disulfide linkages other moieties can be attached to R2 converting the hydrophobic base into a water soluble entity, for ease of delivery, which can be reconverted back to the original compound by biochemical reduction in the blood stream.
US08426364B2 Method of preventing progression of hypertension-induced heart failure with PKC peptides
Methods are described for slowing or inhibiting the progression of heart failure in a mammalian subject suffering from chronic hypertension. The methods involve administering an εPKC, β1PKC, or βIIPKC peptide inhibitor, examples of which are provided.
US08426361B2 Pancreatic polypeptide family motifs, polypeptides and methods comprising the same
The present invention provides novel Pancreatic Polypeptide Family (“PPF”) polypeptides and methods for their use.
US08426360B2 Carbocyclic oxime hepatitis C virus serine protease inhibitors
The present invention discloses compounds of formula I, II, or pharmaceutically acceptable salts, esters, or prodrugs thereof: which inhibit serine protease activity, particularly the activity of hepatitis C virus (HCV) NS3-NS4A protease. Consequently, the compounds of the present invention interfere with the life cycle of the hepatitis C virus and are also useful as antiviral agents. More specifically, the invention relates to oxime compounds containing a carbocyclic P2 unit. The present invention further relates to pharmaceutical compositions comprising the aforementioned compounds for administration to a subject suffering from HCV infection. The invention also relates to methods of treating an HCV infection in a subject by administering a pharmaceutical composition comprising the compounds of the present invention.
US08426358B2 Methods for treating atherosclerosis
The invention provides compounds, pharmaceutical compositions and methods for treating atherosclerosis, inflammation, thrombosis and other conditions and for decreasing or prevention of accumulation of cholesterol in a subject by modifying LCAT polypeptide.
US08426357B2 Multimeric conjugate
The present invention is directed to a multimeric agent and a multimeric conjugate formed from this multimeric agent and a biologically active agent. Said multimeric conjugates have a longer life time in vivo and an increased avidity compared to the unmodified biologically agent. The present invention is further directed to a pharmaceutical or diagnostic composition containing said conjugate as well as to a method of its production. The invention additionally provides the use of said conjugates for the detection, determination, separation and/or isolation of a specific binding partner and for the diagnosis, prophylaxis and treatment of diseases in which the specific binding partner is directly or indirectly involved.
US08426354B2 Fragrance compositions
Provided is a fragrance composition having a natural rose aroma with freshness, sweetness, and softness, which is hardly reproduced by combining aroma components conventionally known as rose aromas. Also provided is a fragrance composition having excellent rose-like naturalness, freshness, and richness. More specifically, provided are: a fragrance composition, having added thereto 2-isopropyl-4-methylthiazole alone or in combination with rose oxide; a method of manufacturing the same; and a method of imparting an aroma to a fragrance composition, the method including adding 2-isopropyl-4-methylthiazole to a base fragrance composition having a rose-like aroma as a main aroma. Also provided are: a rose-like fragrance composition, having added thereto methyl epijasmonate alone or in combination with 2-isopropyl-4-methylthiazole; a method of manufacturing the same; and a method of imparting an aroma to a fragrance composition, the method including adding methyl epijasmonate alone or in combination with 2-isopropyl-4-methylthiazole to a base fragrance composition having a rose-like aroma as a main aroma.
US08426350B2 Detergent composition
A detergent composition comprising three or more distinct regions, the composition comprising one or more anti-corrosion agents and a bleaching compound, wherein, the bleaching compound is predominantly located in a first distinct region, and the one or more anti-corrosion agents are predominantly located in a second distinct region having a pH in the range of from 5 to 8.9 which second distinct region is not in direct contact with the first distinct region, and further wherein the second distinct region has a lower pH than the first distinct region.
US08426348B2 Antimicrobial lubricant compositions
Antimicrobial lubricant compositions are disclosed. The antimicrobial lubricant compositions are particularly useful in providing antimicrobial capability to a wide-range of medical devices. The compositions include an oil lubricant. Representative lubricants may include polydimethyl siloxane, trifluoropropyl copolymer polysiloxane, and a copolymer of dimethylsiloxane and trifluoropropylmethylsiloxane. The compositions include rheology modifiers as necessary. The compositions also include antimicrobial agents, which may be selected from a wide array of agents. Representative antimicrobial agents include of aldehydes, anilides, biguanides, bis-phenols, quaternary ammonium compounds, cetyl pyridium chloride, cetrimide, alexidine, chlorhexidine diacetate, benzalkonium chloride, and o-phthalaldehyde.
US08426345B2 Method of drug design
The invention provides a method of identifying biologically active compounds comprising: (a) designing a first library of compounds of formula (1) to scan molecular diversity wherein each compound of the library has at least two pharmacophoric groups R1 to R5 as defined below and wherein compound of the library has same number of pharmacophoric groups; (b) assaying the first library of compounds in one or more biological assay(s); and (c) designing a second library wherein each compound of the second library contains one or more additional pharmacophoric group with respect to the first library; such that the/each component of the first and second library is a compound of formula (1).
US08426344B2 Method for producing metal substrates for HTS coating arrangements
A method is proposed for producing a biaxially textured metal substrate having a metal surface, wherein the substrate is modified in order to produce a high-temperature superconductor coating arrangement and wherein the metal surface is modified in order to deposit a buffer layer or another intermediate layer epitaxially thereon and/or to deposit an oriented high-temperature superconductor (HTS) layer thereon. The method includes producing a biaxially textured metal substrate, subjecting the metal substrate surface to a polishing treatment, in particular an electropolishing treatment, and subjecting the metal substrate to a post-annealing after the surface polishing treatment and before a subsequent coating is performed involving epitaxial deposition of a layer of the HTS coating arrangement. This method results in smooth metal substrates with high textural overcoats and thereby improved HTS layers.
US08426343B2 Method of improving grass quality
The invention relates to a method of improving grass quality comprising applying an effective amount of a composition containing a phthalocyanine to the grass in the substantial absence of phosphorous acid, monoalkyl esters of phosphorous acid, or salts thereof.
US08426340B2 Plant growth enhancement with combinations of PESA and plant growth regulators
A combination treatment of N-(phenylethyl)succinamic acid or its salts and a plant growth regulator applied as a seed treatment or applied directly on or near the root zone of the seedling or growing plant promotes plant growth is disclosed.
US08426327B2 Alkali-free glass and alkali-free glass substrate, and method of producing the same
A technical object of the present invention is to satisfy various properties required in glass for liquid crystal displays and the like, in particular, fusibility, devitrification resistance, and like properties, and then to design a glass composition in which components harmful to the environment are reduced or substantially not contained, thereby obtaining a glass substrate that takes the environment into consideration. An alkali-free glass of the present invention contains the following glass composition in percent by weight based on oxide: 50 to 70% of SiO2, 10 to 20% of Al2O3, 8 to 12% of B2O3, 0 to 3% of MgO, 4 to 15% of CaO, 0 to 10% of SrO, 0 to 1% of BaO, and 0 to 5% of ZnO, and substantially free of alkali metal oxide and As2O3.
US08426321B1 Weak-link capacitor
A process for making a dielectric material where a precursor polymer selected from poly(phenylene vinylene)polyacetylene, poly(p-phenylene), poly(thienylene vinylene), poly(1,4-naphthylene vinylene), and poly(p-pyridine vinylene) is energized said by exposure by radiation or increase in temperature to a level sufficient to eliminate said leaving groups contained within the precursor polymer, thereby transforming the dielectric material into a conductive polymer. The leaving group in the precursor polymer can be a chloride, a bromide, an iodide, a fluoride, an ester, an xanthate, a nitrile, an amine, a nitro group, a carbonate, a dithiocarbamate, a sulfonium group, an oxonium group, an iodonium group, a pyridinium group, an ammonium group, a borate group, a borane group, a sulphinyl group, or a sulfonyl group.
US08426319B2 Composition for etching a metal hard mask material in semiconductor processing
An etching solution for a metal hard mask. The etching solution comprises a mixture of a dilute HF (hydrofluoric acid) and a silicon containing precursor. The etching solution also comprises a surfactant agent, a carboxylic acid, and a copper corrosion inhibitor. The etching solution is selectively toward etching the metal hard mask material (e.g., Titanium) while suppressing Tungsten, Copper, oxide dielectric material, and carbon doped oxide.
US08426318B2 Method of setting thickness of dielectric and substrate processing apparatus having dielectric disposed in electrode
Provided is a method of setting a thickness of a dielectric, which restrains the dielectric formed in an electrode from being consumed when etching a silicon dioxide film on a substrate by using plasma. In a substrate processing apparatus including an upper electrode facing a susceptor and the dielectric formed of silicon dioxide in the upper electrode, a silicon dioxide film formed on a wafer being etched by using plasma, an electric potential of the plasma facing the dielectric in a case where the dielectric is not formed in the upper electrode is estimated based on a bias power applied to the susceptor and an A/C ratio in a chamber, and the thickness of the dielectric is determined so that an electric potential of the plasma, which is obtained by multiplying the estimated electric potential of the plasma by a capacity reduction coefficient calculated when a capacity of the dielectric and a capacity of a sheath generated around a surface of the dielectric are combined, is 100 eV or less.
US08426317B2 Plasma processing apparatus and plasma processing method
An optimum application voltage for reducing deposits on a peripheral portion of a substrate as well as improving a process result in balance is effectively found without changing a height of a focus ring. A plasma processing apparatus includes a focus ring which includes a dielectric ring provided so as to surround a substrate mounting portion of a mounting table and a conductive ring provided on the dielectric ring; a voltage sensor configured to detect a floating voltage of the conductive ring; a DC power supply configured to apply a DC voltage to the conductive ring. An optimum voltage to be applied to the conductive ring is obtained based on a floating voltage actually detected from the conductive ring, and the optimum application voltage is adjusted based on a variation in the actually detected floating voltage for each plasma process.
US08426306B1 Three dimension programmable resistive random accessed memory array with shared bitline and method
A method of forming a non-volatile memory device. The method forms a vertical stack of first polysilicon material and a second polysilicon material layer isolated by a dielectric material. The polysilicon material layers and the dielectric material are subjected to a first pattern and etch process to form a first wordline associated with a first switching device and a second wordline associated with a second switching device from the first polysilicon material layer, and a third wordline associated with a third switching device and a fourth wordline associated with a fourth switching device from the second polysilicon material. A via opening is formed to separate the first wordline from the second wordline and to separate the third wordline from the fourth wordline. An amorphous silicon switching material is deposited conformably overlying the via opening. A metal material fills the via opening and connects to a common bitline.
US08426300B2 Self-aligned contact for replacement gate devices
A conductive top surface of a replacement gate stack is recessed relative to a top surface of a planarization dielectric layer by at least one etch. A dielectric capping layer is deposited over the planarization dielectric layer and the top surface of the replacement gate stack so that the top surface of a portion of the dielectric capping layer over the replacement gate stack is vertically recessed relative to another portion of the dielectric layer above the planarization dielectric layer. The vertical offset of the dielectric capping layer can be employed in conjunction with selective via etch processes to form a self-aligned contact structure.
US08426295B2 Manufacturing method of microcrystalline silicon film and manufacturing method of semiconductor device
To provide a manufacturing method of a microcrystalline silicon film having both high crystallinity and high film density. In the manufacturing method of a microcrystalline silicon film according to the present invention, a first microcrystalline silicon film that includes mixed phase grains is formed over an insulating film under a first condition, and a second microcrystalline silicon film is formed thereover under a second condition. The first condition and the second condition are a condition in which a deposition gas containing silicon and a gas containing hydrogen are used as a first source gas and a second source gas. The first source gas is supplied under the first condition in such a manner that supply of a first gas and supply of a second gas are alternately performed.
US08426290B1 Suspended-membrane/suspended-substrate monolithic microwave integrated circuit modules
A device and a method for manufacturing it are disclosed. The device contains a plurality of transistors, a plurality of transmission mediums connected to the transistors; and a substrate having a first portion supporting the transistors and the transmission mediums thereon, and further having a plurality of discrete second portions extending from the first portion. The method disclosed teaches how to manufacture the device.
US08426287B2 Method of manufacturing semiconductor device, solid-state imaging device, and solid-state imaging apparatus
A method of manufacturing a semiconductor device includes the steps of forming a gate electrode of a transistor on an insulator layer on a surface of a semiconductor substrate, forming an isolation region by performing ion implantation of an impurity of a first conductivity type into the semiconductor substrate, forming a lightly doped drain region by performing, after forming a mask pattern including an opening portion narrower than a width of the gate electrode on an upper layer of the gate electrode of the transistor, ion implantation of an impurity of a second conductivity type near the surface of the semiconductor substrate with the mask pattern as a mask, and forming a source region and a drain region of the transistor by performing ion implantation of an impurity of the second conductivity type into the semiconductor substrate after forming the gate electrode of the transistor.
US08426286B2 Method and device for a DRAM capacitor having low depletion ratio
A method of manufacturing a semiconductor integrated circuit device having low depletion ratio capacitor comprising: forming hemispherical grains (HSG) on a poly-silicon; doping the hemispherical grained polysilicon in a phosphine gas; and rapid thermal oxidizing the doped hemispherical grained polysilicon at 850° C. for 10 seconds. The method further comprises nitridizing the rapid thermal oxidized hemispherical-grained polysilicon and depositing a alumina film on the silicon nitride layer. A semiconductor integrated circuit device having a low depletion ratio capacitor according to the disclosed manufacturing method is provided.
US08426279B2 Asymmetric transistor
According to one exemplary embodiment, an asymmetric transistor includes a channel region having a drain-side channel portion and a source-side channel portion. The asymmetric transistor can be an asymmetric MOSFET. The source-side channel portion can comprise silicon, for example. The drain-side channel portion can comprise germanium, for example. The asymmetric transistor comprises a vertical heterojunction situated between the drain-side channel portion and the source-side channel portion. According to this exemplary embodiment, the bandgap of the source-side channel portion is higher than the bandgap of the drain-side channel portion and the carrier mobility of the drain-side channel portion is higher than the carrier mobility of the source-side channel portion. The transistor can further include a gate oxide layer situated over the drain-side channel portion and the source-side channel portion, and can also include a gate situated over the gate oxide layer.
US08426278B2 Semiconductor devices having stressor regions and related fabrication methods
Apparatus for semiconductor device structures and related fabrication methods are provided. A method for fabricating a semiconductor device structure on an isolated region of semiconductor material comprises forming a plurality of gate structures overlying the isolated region of semiconductor material and masking edge portions of the isolated region of semiconductor material. While the edge portions are masked, the fabrication method continues by forming recesses between gate structures of the plurality of gate structures and forming stressor regions in the recesses. The method continues by unmasking the edge portions and implanting ions of a conductivity-determining impurity type into the stressor regions and the edge portions.
US08426269B2 Method for fabricating semiconductor device
A method for fabricating a semiconductor device includes forming junction area for a bit line contact (BLC) and a junction area for a storage node contact (SNC) by performing ion implantation in a substrate having a buried gate; forming a first insulation pattern having an opening to expose the junction areas; forming a buffer layer to fill the openings; forming a second insulation pattern over the first insulation pattern after filling the openings, wherein the second insulation pattern has openings to expose the buffer layer in an area of the buffer layer that lies over the junction area for the SNC; and forming an SNC to fill the opening of the second insulation patterns.
US08426266B2 Stress memorization with reduced fringing capacitance based on silicon nitride in MOS semiconductor devices
In sophisticated semiconductor devices, stress memorization techniques may be applied on the basis of a silicon nitride material, which may be subsequently modified into a low-k dielectric material in order to obtain low-k spacer elements, thereby enhancing performance of sophisticated semiconductor devices. The modification of the initial silicon nitride-based spacer material may be accomplished on the basis of an oxygen implantation process.
US08426263B2 Patterning a gate stack of a non-volatile memory (NVM) with formation of a metal-oxide-semiconductor field effect transistor (MOSFET)
A first dielectric layer is formed on a substrate in a transistor region and an NVM region, a first conductive layer is formed on the first dielectric layer, a second dielectric layer is formed on the first conductive layer, and a second conductive layer is formed over the second dielectric layer. A patterned etch is performed to remove at least a portion of the second conductive layer in the transistor region and to expose an extension portion of the first conductive layer. A first mask is formed over the transistor region having a first pattern, wherein the first pattern is of a gate stack of the MOSFET and an extension in the extension portion extending from the gate stack, and a second mask over the NVM region having a second pattern, wherein the second pattern is of a gate stack of the NVM cell. A patterned etch is then performed.
US08426261B2 High-k heterostructure
A method for preparing a multilayer substrate includes the step of deposing an epitaxial γ-Al2O3 Miller index (001) layer on a Si Miller index (001) substrate.
US08426256B2 Method of forming stacked-die packages
A method of forming a stacked die structure is disclosed. A plurality of dies are respectively bonded to a plurality of semiconductor chips on a first surface of a wafer. An encapsulation structure is formed over the plurality of dies and the first surface of the wafer. The encapsulation structure covers a central portion of the first surface of the wafer and leaves an edge portion of the wafer exposed. A protective material is formed over the first surface of the edge portion of the wafer.
US08426255B2 Chip package structure and method for manufacturing the same
A method for manufacturing a semiconductor package structure is disclosed. In one embodiment, the method includes the steps of forming a plurality of conductive pastes on a matrix lead frame with a groove located within a predetermined distance from each conductive paste on the lead; partially curing the conductive pastes so that the conductive pastes are in a semi-cured state; preparing at least one chip with a plurality of bumps thereon; electrically connecting the chip and the lead by implanting the bumps into the semi-cured conductive pastes, wherein the groove on the lead of the matrix lead frame is configured to receive overflowed semi-cured conductive pastes; curing the semi-cured conductive pastes to completely secure the bumped chip; and forming an encapsulating material covering the lead frame and the chip. The method can also be applied in pre-molded lead frame package.
US08426253B2 Potted integrated circuit device with aluminum case
An integrated circuit device includes a die, a lead, and an electrically-conductive structure that is arranged to facilitate electrical communication between the die and the lead. The device also includes a potting material, in which the electrically conductive structure, the die, and at least part of the lead are embedded. An electrically-conductive housing encases the potting material and forms exterior packaging of the device. During manufacturing, the electrically-conductive structure, the die, and at least part of the lead may be arranged within the electrically-conductive housing either before or after the potting material is disposed in the housing. When the integrated circuit device is operating, heat is removable from the die via a thermal conduction path formed by the electrically-conductive structure, the potting material, and the electrically-conductive housing.
US08426251B2 Semiconductor device
A method of manufacturing a semiconductor device includes providing a carrier and attaching a plurality of semiconductor chips to the carrier. The semiconductor chips have a first electrode pad on a first main face and at least a second electrode pad on a second main face opposite to the first main face, whereby the first electrode pad is electrically connected to the carrier. A plurality of first bumps are formed on the carrier, the first bumps being made of a conductive material. The carrier is then singulated into a plurality of semiconductor devices, wherein each semiconductor device includes at least one semiconductor chip and one first bump.
US08426249B2 Chip part manufacturing method and chip parts
The present invention provides a chip part manufacturing method comprising a separating process capable of suppressing deformation of chip parts, and also provides chip parts. It comprises a step of forming a plurality of frame-like void portions (32) in one main surface of substrate (30) and insulating resin layer (20) having a spiral void portion (40) disposed in the region thereof, a step of forming metal layer (36) in frame-like void portion (32) and spiral void portion (40) and on insulating resin layer (20), a step of polishing metal layer (36) at least up to the upper surface of insulating resin layer and forming coil section (18) in spiral void portion (40), and a step of forming a metal layer for connecting chip parts to frame-like void portion (32), wherein the metal layer is melted and removed by using an etching agent to separate a plurality of chip parts connected to each other by a frame-like connection.
US08426245B2 Packaging method involving rearrangement of dice
A packaging method is disclosed that comprises attaching a plurality of dice, each having a plurality of bonding pads disposed on an active surface, to an adhesive layer on a substrate. A polymer material is formed over at least a portion of both the substrate and the plurality of dice and a molding apparatus is used on the substrate to force the polymer material to substantially fill around the plurality of dice. The molding apparatus is removed to expose a surface of the polymer material and a plurality of cutting streets is formed on an exposed surface of the polymer material. The substrate is removed to expose the active surface of the plurality of dice.
US08426242B2 Composite target sputtering for forming doped phase change materials
A layer of phase change material with silicon or another semiconductor, or a silicon-based or other semiconductor-based additive, is formed using a composite sputter target including the silicon or other semiconductor, and the phase change material. The concentration of silicon or other semiconductor is more than five times greater than the specified concentration of silicon or other semiconductor in the layer being formed. For silicon-based additive in GST-type phase change materials, sputter target may comprise more than 40 at % silicon. Silicon-based or other semiconductor-based additives can be formed using the composite sputter target with a flow of reactive gases, such as oxygen or nitrogen, in the sputter chamber during the deposition.
US08426240B2 Method for manufacturing photovoltaic device including flexible or inflexible substrate
Disclosed is a method for manufacturing a photovoltaic device including: a forming the first sub-layer including impurity by allowing first flow rate values of the source gas introduced into one group of a first group consisting of odd numbered process chambers and a second group consisting of even numbered process chambers to be maintained constant in each of the process chambers of the one group; and a forming the second sub-layer including impurity by allowing second flow rate values of the source gas introduced into the other group of the first group and the second group to be maintained constant in each of the process chambers of the other group, wherein the second flow rate values are less than the first flow rate values.
US08426237B2 Assembly techniques for solar cell arrays and solar cells formed therefrom
An assembly technique for assembling solar cell arrays is provided. During the fabrication of a solar cell, openings through the semiconductor layer are etched through to a top surface of the backmetal layer. The solar cells include an exposed top surface of the backmetal layer. A plurality of solar cells are assembled into a solar cell array where adjacent cells are interconnected in an electrically serial or parallel fashion solely from the top surface of the solar cells.
US08426236B2 Method and structure of photovoltaic grid stacks by solution based processes
A grid stack structure of a solar cell, which includes a silicon substrate, wherein a front side of the silicon is doped with phosphorus to form a n-emitter and a back side of the silicon is screen printed with aluminum (Al) metallization; a dielectric layer, which acts as an antireflection coating (ARC), applied on the silicon; a mask layer applied on the front side to define a grid opening of the dielectric layer, wherein an etching method is applied to open an unmasked grid area; a light-induced plated nickel or cobalt layer applied to the front side with electrical contact to the back side Al metallization; a silicide layer formed by rapid thermal annealing of the plated nickel (Ni) or cobalt (Co); an optional barrier layer electrodeposited on the silicide; a copper (Cu) layer electrodeposited on the silicide/barrier film layer; and a thin protective layer is chemically applied or electrodeposited on top of the Cu layer.
US08426233B1 Methods of packaging microelectromechanical resonators
Methods of forming packaged microelectromechanical resonators include forming a first isolation trench in a first surface of a capping substrate, with the first isolation trench encircling a first portion of the capping substrate. The first isolation trench is filled with an electrically insulating material. The first surface of the capping substrate is bonded to a device substrate, which includes the microelectromechanical resonator and at least a first electrically conductive line connected to the microelectromechanical resonator. A second surface of the capping substrate is planarized for a sufficient duration to thereby expose the electrically insulating material and the first portion of the capping substrate encircled by the first isolation trench. The exposed first portion of the capping substrate is selectively etched to thereby define a through-substrate opening therein, which exposes a first portion of the first electrically conductive line. At least a portion of the through-substrate opening is filled with an electrically conductive through-substrate via, which is electrically connected to the first portion of the first electrically conductive line.
US08426232B2 Ultra-fast nucleic acid sequencing device and a method for making and using the same
A system and method employ at least one semiconductor device, or an arrangement of insulating and metal layers, having at least one detecting region which can include, for example, a recess or opening therein, for detecting a charge representative of a component of a polymer, such as a nucleic acid strand proximate to the detecting region. A method for manufacturing forms such a semiconductor device. The system and method can be used for sequencing individual nucleotides or bases of ribonucleic acid (RNA) or deoxyribonucleic acid (DNA). The detecting region permits a current to pass between the two doped regions in response to the presence of the component of the polymer, such as a base of a DNA or RNA strand. The current has characteristics representative of the component of the polymer, such as characteristics representative of the detected base of the DNA or RNA strand.
US08426227B1 Method of forming a micro light emitting diode array
A micro light emitting diode (LED) and a method of forming an array of micro LEDs for transfer to a receiving substrate are described. The micro LED structure may include a micro p-n diode and a metallization layer, with the metallization layer between the micro p-n diode and a bonding layer. A conformal dielectric barrier layer may span sidewalls of the micro p-n diode. The micro LED structure and micro LED array may be picked up and transferred to a receiving substrate.
US08426226B2 Method for fabricating integrated alternating-current light-emitting-diode module
A method for fabricating an integrated AC LED module comprises steps: forming a junction layer on a substrate, and defining a first growth area and a second growth area on the junction layer; respectively growing a Schottky diode and a LED on the first growth area and the second growth area; forming a passivation layer and a metallic layer on the Schottky diode, the LED and the substrate. Thereby, the Schottky diode is electrically connected with the LED via the metallic layer. Thus is promoted the reliability of electric connection of diodes, reduced the layout area of the module, and decreased the fabrication cost.
US08426223B2 Wafer edge inspection
Wafer edge inspection approaches are disclosed wherein an imaging device captures at least one image of an edge of a wafer. The at least one image can be analyzed in order to identify an edge bead removal line. An illumination system having a diffuser can further be used in capturing images.
US08426216B2 Methods for authenticating articles with optical reporters
This invention pertains to methods for authenticating an article comprising tagging the article with light emitting optical reporter particles, and more specifically tagging the articles with up-converting phosphor particles (UCP), linked to nucleic acids of detectable sequence.
US08426215B2 Gas chromatograph and method for analyzing a mixture of substances by gas chromatography
A gas chromatograph for analyzing natural gas, with a first separation column (6). A first detector (7) is provided following the first separation column, the first separation column and the first detector operable to separate or detect propane and higher hydrocarbons. A second separation column (8) and a second detector (9) following it are provided to separate or detect carbon dioxide and ethane. A third separation column (10) and a third detector (11) following it are provided to separate or detect nitrogen and methane. A controllable changeover device (12) is provided between the second separation column (8) and the third separation column (10) to discharge eluates following methane. The first, second and third separation columns (6, 8, 10) and the first, second and third detectors (7, 9, 11) are connected in series. At least the first and the second detectors (7, 9) are operable to detect a mixture of substances flowing through them in a non-destructive manner.
US08426209B2 Methods and apparatus for sorting cells using an optical switch in a microfluidic channel network
Apparatus and Methods are provided for a microfabricated fluorescence activated cell sorter based on an optical switch for rapid, active control of cell routing through a microfluidic channel network. This sorter enables low-stress, highly efficient sorting of populations of small numbers of cells (i.e., 1000-100,000 cells). The invention includes packaging of the microfluidic channel network in a self-contained plastic cartridge that enables microfluidic channel network to macro-scale instrument interconnect, in a sterile, disposable format.
US08426206B2 Protein for use in modifying abiotic stress tolerance in yeast
A method is presented for selecting and isolating nucleic acids capable of conferring tolerance or resistance to environmental stress conditions in plants or yeast. Furthermore, nucleic acids, the proteins they encode and their use for the production of plants or yeast with enhanced environmental stress resistance is disclosed.
US08426201B2 Ion channel assay methods
A method of characterizing the biological activity of a candidate compound may include exposing cells to the candidate compound, and then exposing the cells to a repetitive application of electric fields so as to set the transmembrane potential to a level corresponding to a pre-selected voltage dependent state of a target ion channel.
US08426200B2 Neuronal differentiation of stem cells
The present invention relates to compositions and methods for culturing stem cells, such that neuronal differentiation can be achieved.
US08426199B2 Method for the treatment of biological tissue of animal or human origin, such as porcine, bovine pericardium or human cadaver heart valves, and biological tissue treated accordingly
A method for treating glutardialdehyde-stabilized biological tissue of animal or human origin, such as porcine, bovine pericardium or human cadaver heart valves, provides a physical plasma treatment of the, in particular, collagen tissue for increasing the biocompatibility, cell colonization and durability thereof.
US08426198B2 In vitro differentiated cell and human embryonic stem cell population
This invention provides a system for producing differentiated cells from a stem cell population for use wherever a relatively homogenous cell population is desirable. The cells contain an effector gene under control of a transcriptional control element (such as the TERT promoter) that causes the gene to be expressed in relatively undifferentiated cells in the population. Expression of the effector gene results in depletion of undifferentiated cells, or expression of a marker that can be used to remove them later. Suitable effector sequences encode a toxin, a protein that induces apoptosis; a cell-surface antigen, or an enzyme (such as thymidine kinase) that converts a prodrug into a substance that is lethal to the cell. The differentiated cell populations produced according to this disclosure are suitable for use in tissue regeneration, and non-therapeutic applications such as drug screening.
US08426197B2 Methods and apparatus for reducing protein content in sperm cell extenders
The inventive technology relates to methods and apparatus for reducing protein content in sperm cell extenders and may include one or more of the following features: techniques for reducing protein content in a sperm cell extender; techniques for reducing protein content in a cryoprotectant-containing B fraction of a sperm cell extender; techniques for preparing sperm cell extenders that do not require clarification; techniques for preparing low density gradient sperm cell extenders suitable for centrifugation; techniques for reducing protein content between individual steps in preparing a sperm cell extender, and techniques for establishing novel values of reduced protein content in sperm cell extenders.
US08426195B2 Promoter nucleic acid molecule derived from corynebacterium glutamicum, recombinant vector comprising the promoter, host cell comprising the recombinant vector and method of expressing gene using the host cell
Provided are a novel promoter nucleic acid molecule having a nucleotide sequence of SEQ ID NO: 1 or 2 derived from Corynebacterium glutamicum, a recombinant vector comprising the promoter, a host cell transformed with the vector and a method of expressing genes of interest using the host cell.
US08426192B2 Composite membrane containing a cross-linked enzyme matrix for a biosensor
An electrochemical sensor system and membrane and method thereof for increased accuracy and effective life of electrochemical and enzyme sensors.
US08426185B2 Thermophilic and thermoacidophilic biopolymer-degrading genes and enzymes from Alicyclobacillus acidocaldarius and related organisms, methods
Isolated and/or purified polypeptides and nucleic acid sequences encoding polypeptides from Alicyclobacillus acidocaldarius are provided. Further provided are methods of at least partially degrading, cleaving, or removing polysaccharides, lignocellulose, cellulose, hemicellulose, lignin, starch, chitin, polyhydroxybutyrate, heteroxylans, glycosides, xylan-, glucan-, galactan-, or mannan-decorating groups using isolated and/or purified polypeptides and nucleic acid sequences encoding polypeptides from Alicyclobacillus acidocaldarius.
US08426175B2 Method for the production of a fermentation product from a pretreated lignocellulosic feedstock
A method for obtaining a fermentation product from a sugar hydrolysate obtained from a feedstock containing hemicellulose, by (i) removing suspended fiber solids from said sugar hydrolysate to obtain a clarified sugar solution; (ii) fermenting xylose in the clarified sugar solution in a fermentation reaction with yeast to produce a fermentation broth comprising the fermentation product; (iii) separating the yeast from the fermentation broth to produce a yeast slurry; (vi) treating the yeast slurry thus obtained with an oxidant to kill microbial contaminants, thereby an oxidant-treated yeast slurry; (v) re-introducing at least a portion of the oxidant-treated yeast back to step (ii) to increase the concentration of yeast in said fermentation reaction; and (vi) recovering the fermentation product.
US08426173B2 Method for the production of 1-butanol
A method for the production of 1-butanol by fermentation using a microbial production host is disclosed. The method employs a reduction in temperature during the fermentation process that results in a more robust tolerance of the production host to the butanol product.
US08426172B2 Transformant capable of producing isopropanol
A transformant capable of producing isopropanol which is constructed by transferring the following genes (a) to (d) into an aerobic bacterium or a facultative anaerobic bacterium: (a) a foreign gene which encodes an enzyme having acetyl-CoA acetyltransferase activity; (b) a foreign gene which encodes an enzyme having acetoacetyl CoA:acetate CoA-transferase activity; (c) a foreign gene which encodes an enzyme having acetoacetate decarboxylase activity; and (d) a foreign gene which encodes an enzyme having isopropanol dehydrogenase activity.
US08426171B2 Microorganism producing L-methionine precursor and method of producing L-methionine and organic acid from the L-methionine precursor
The present invention relates to a method for producing L-methionine and organic acid comprising the following steps: Step 1) preparing a strain producing L-methionine precursor and producing L-methionine precursor by the fermentation of the strain; Step 2) producing L-methionine and organic acid by the enzyme reaction process with the L-methionine precursor as a substrate, and microorganism strains used in each step.
US08426165B2 Process for producing fermentation product from carbon sources containing glycerol using Corynebacteria
The present invention relates to a method for producing fermentation product from various carbon sources containing glycerol using Corynebacteria. More particularly, the present invention relates to a method for producing fermentation product from carbon sources containing glycerol or a part of glycerol with high yield and high productivity, by fermenting Corynebacteria introduced with the foreign gene glpDFK facilitating the use of glycerol and accumulating industrially useful amino acids in the culture medium.
US08426160B2 Processes of producing fermentation products
The invention relates to a process of fermenting plant material in a fermentation medium into a fermentation product using a fermenting organism, wherein one or more carbonic anhydrases are present in the fermentation medium.
US08426157B2 Method for analyzing the effect of a gaseous medium on a biological test system using an extracellular metabolization system
The invention relates to a method for analyzing the effect of a gaseous medium on a biological test system using an extracellular metabolization system. The method consists of the following steps: a biological test sample is cultivated on a permeable carrier, the gaseous medium is guided over the surface of the biological test system in order to form an exposition atmosphere over the biological test system, the extracellular metabolization system is added to a conservation medium and the permeable carrier is brought into contact with a conservation medium that comprises the extracellular metabolization system below the permeable carrier, in such a manner that the extracellular metabolization system only passes through the permeable carrier and that the biological test system is not submerged by the conservation medium containing the extracellular metabolization system.
US08426156B2 Method for assaying plasma enzymes in whole blood
The present invention relates to a method for assaying catalytic plasma enzymes, such as transaminases and NADH-dependent enzymes, in a sample of whole blood, by measuring, in a microfluidic chamber, the decrease in the fluorescence of NADH consumed during the enzymatic reactions catalyzed by the NADH-dependent enzymes.
US08426155B2 Proteome analysis in mass spectrometers containing RF ion traps
A complex protein mixture is analyzed by jointly digesting the mixture, separating the digest peptides chromatographically or electrophoretically, and ionizing the digest peptides eluting from the separation device by an ionizing method that generates multiply charged ions. Digest peptide ions within a pre-selected range of m/z-values are isolated in an RF ion trap and subsequently reduced in their charge state. The charge-reduced ions can be measured with very high sensitivity. By repeating this process with adjacent isolation mass windows within the time duration of each separation peak, it is possible to determine the masses m, the prevalent charge states z, the retention times t, and the intensities i of a huge number of digest peptides of the complex protein mixture in a single separation run.
US08426149B2 Granzyme A and granzyme B diagnostics
A method for identifying a subject being at risk for or having a chronic inflammatory disease, fibrillinopathy, atherosclerosis, or coronary artery disease is provided. The method may include determining the concentration of GrA and/or GrB in a blood or serum sample from said subject; and comparing the concentrations to the corresponding concentration in a control sample, wherein an elevated concentration of GrA and/or GrB may be indicative of a chronic inflammatory disease, fibrillinopathy, atherosclerosis, or coronary artery disease. The method may further include identifying concentrations of fibrinogen, elastin and/or fibrillin.
US08426145B2 Diagnostic method for celiac sprue
Detection of toxic gluten oligopeptides refractory to digestion and antibodies and T cells responsive thereto can be used to diagnose Celiac Sprue.
US08426136B2 Epigenetic modifications at TNFα as biomarkers for sensitivity to Smac mimetic-induced apoptosis
The invention provides a method for determining sensitivity of a cell population to apoptosis induced by Smac mimetics as a single agent or in combination with other chemodrugs, which method comprises assaying for an epigenetic modification at the TNFα locus in the cell population as compared to the TNFα locus in a cell population not sensitive to apoptosis induced by Smac mimetics as a single agent or in combination with other chemodrugs, wherein the presence of the epigenetic modification indicates that the cell population is sensitive to apoptosis induced by Smac mimetics as a single agent or in combination with other chemodrugs.
US08426134B2 Recombinase polymerase amplification
This disclosure describes related novel methods for Recombinase-Polymerase Amplification (RPA) of a target DNA that exploit the properties of recombinase and related proteins, to invade double-stranded DNA with single stranded homologous DNA permitting sequence specific priming of DNA polymerase reactions. The disclosed methods have the advantage of not requiring thermocycling or thermophilic enzymes, thus offering easy and affordable implementation and portability relative to other amplification methods. Further disclosed are conditions to enable real-time monitoring of RPA reactions, methods to regulate RPA reactions using light and otherwise, methods to determine the nature of amplified species without a need for gel electrophoresis, methods to improve and optimize signal to noise ratios in RPA reactions, methods to optimize oligonucleotide primer function, methods to control carry-over contamination, and methods to employ sequence-specific third ‘specificity’ probes. Further described are novel properties and approaches for use of probes monitored by light in dynamic recombination environments.
US08426131B2 Method for screening candidate compounds for antitumor drug
Investigation on the frequency of FLT3/ITD found in various blood cancers has revealed that the frequency is high in acute myeloblastic leukemia in particular. Studies on the effects of FLT3/ITD in the blood cell lines revealed that the tyrosine residues in FLT3/ITD is constitutively phosphorylated in these cell lines and that blood cells into which FLT3/ITD is introduced show IL-3 independent proliferation. Moreover, the blood cells into which FLT3/ITD is introduced are found to be capable of forming tumors and inhibit cell differentiation. The inventors have found that it is possible to screen for pharmaceutical compounds against tumors by using inhibition of these FLT3/ITD functions as an index.
US08426129B2 Method for typing HLA alleles
The present invention relates to the typing of HLA alleles. The sequence of exon 2 and exon 3 of the alleles HLA-B*3913, HLA-B*1406 and HLA-B*51new and of exon 2 of the alleles HLA-DRB1*0820, HLA-DRB1*04new and HLA-DRB4*01new are disclosed. The present invention relates to methods for typing of the alleles HLA-B*3913, HLA-B*1406 and HLA-B*51new. The present invention further provides primers and probes to be used in the methods for typing. A diagnostic kit comprising these primers and probes is also part of the present invention.
US08426126B2 Modified surfaces as solid supports for nucleic acid purification
The invention relates to methods of separating polynucleotides, such as DNA, RNA and PNA, from solutions containing polynucleotides by reversibly binding the polynucleotides to a solid surface, such as a magnetic microparticle.
US08426125B2 Method of pretreating specimen and immunoassay using the same
The present invention provides a method of pretreating a specimen, which allows measurement according to an immunoassay to be carried out on a specimen from nasal secretion while preventing non-specific reactions. According to this method, the specimen from nasal secretion is treated with a protease beforehand and then an immunoassay is performed. As the protease, it is preferable to use semi-alkaline protease (EC 3.4.21.63). Furthermore, it is preferable that a substance to be pretreated by the pretreatment method according to the present invention is an influenza virus contained in the specimen from nasal secretion. The immunoassay preferably is an immunoagglutination assay. Examples of the immunoagglutination assay include a turbidimetric immunoassay, a latex turbidimetric immunoassay, and a latex agglutination assay that is performed on a slide glass.
US08426124B2 Two-step temperature profile for the propagation of viruses
The present invention provides a method for the production of a virus. The method includes providing a host cell that has been infected by the virus and cultivating the infected host cell at two different temperatures. The virus produced by the cultivation steps is subsequently collected. By using the dual temperature cultivation process, high titer and improved purity can be obtained.
US08426123B2 Method for conducting an assay for neutralizing antibodies
A method for conducting a neutralization assay for the determination of the titer of antibodies in a sample is provided which is an improvement over existing neutralization assays because the sensitivity of the reporter gene assay to determine neutralization is increased by the use of a “one time use” cell line transformed with a reporter gene construct. The titer is determined for antibodies specific for a predetermined target molecule that activates the signal transduction activity of a cell surface protein or a pattern recognition receptor or are specific for an antagonist for the predetermined target molecule.
US08426122B2 Method and device for identification of nucleated red blood cells from a maternal blood sample
A method for concentrating and isolating nucleated cells, such as a maternal and fetal nucleated red blood cells (NRBC's), in a maternal whole blood sample. The invention also provides methods and apparatus for preparing to analyze and analyzing the sample for identification of fetal genetic material as part of prenatal genetic testing. The invention also pertains to methods and apparatus for discriminating fetal nucleated red blood cells from maternal nucleated red blood cells obtained from a blood sample taken from a pregnant woman.
US08426118B2 Method of forming pitch multiplied contacts
Methods of forming electrically conductive and/or semiconductive features for use in integrated circuits are disclosed. Various pattern transfer and etching steps can be used, in combination with pitch-reduction techniques, to create densely-packed features. The features can have a reduced pitch in one direction and a wider pitch in another direction. Conventional photo-lithography steps can be used in combination with pitch-reduction techniques to form elongate, pitch-reduced features such as bit-line contacts, for example.
US08426117B2 Mask pattern forming method, fine pattern forming method, and film deposition apparatus
In a mask pattern forming method, a resist film is formed over a thin film, the resist film is processed into resist patterns having a predetermined pitch by photolithography, slimming of the resist patterns is performed, and an oxide film is formed on the thin film and the resist patterns after an end of the slimming step in a film deposition apparatus by supplying a source gas and an oxygen radical or an oxygen-containing gas. In the mask pattern forming method, the slimming and the oxide film forming are continuously performed in the film deposition apparatus.
US08426105B2 Resist-modifying composition and pattern forming process
A patterning process includes (1) coating a first positive resist composition onto a substrate, baking, exposing, post-exposure baking, and alkali developing to form a first resist pattern, (2) coating a resist-modifying composition onto the first resist pattern and heating to effect modifying treatment, and (3) coating a second positive resist composition, baking, exposing, post-exposure baking, and alkali developing to form a second resist pattern. The resist-modifying composition comprises a carbamate compound and a solvent.
US08426099B2 Colored resin particles, manufacturing method of the colored resin particles and toner for electrostatically charged image development
Colored resin particles, each includes: a resin; and a colorant, wherein a value of average equivalent circle diameter A (μm) of the colored resin particles is 3≦A≦6, an average degree of circularity B of the colored resin particles satisfies the following expression (1), and 0.990−0.0083A≦B≦1.021−0.0117A  (1) a cumulative number frequency of particles which have degrees of circularity of less than 0.9 in the colored resin particles is 1% or less.
US08426095B2 Toner
Disclosed is a decolorable toner containing a binder resin and a coloring agent which contains a color former compound and a color developing agent and has a capsule structure such that it is covered with an outer shell, and having a volume average particle diameter of from 5.0 to 15.0 μm and a number-based particle size distribution CV of 35% or less.
US08426093B2 Electrophotographic photoreceptor, process cartridge and image-forming apparatus
An electrophotographic photoreceptor including a photosensitive layer provided including a first functional layer including a compound represented by the following Formula (I). In Formula (I), F represents an n-valent organic group having hole transportation ability; R1, R2, and R3 each independently represents a hydrogen atom, a halogen atom, or a monovalent organic group; L represents a divalent organic group; n represents an integer of 1 to 4; and j represents an integer of 0 or 1.
US08426082B2 Programmable self-aligning liquid magnetic nanoparticle masks and methods for their use
Magnetic nanoparticle masks for lithographic applications of a substrate and methods for producing such masks via defining regions of localized magnetic field maxima and minima on a substrate are provided. Also provided are methods for producing multi-component patterns on a substrate with the magnetic nanoparticle masks.
US08426081B2 Polybenzoxazine-based compound, electrolyte membrane including the same, and fuel cell employing the electrolyte membrane
A method of preparing an electrolyte membrane comprising a crosslinked object of a polybenzoxazine-based compound formed of a polymerized resultant product of a first monofunctional benzoxazine-based monomer or a second benzoxazine-based monomer multifunctional benzoxazine-based monomer with a crosslinkable compound.
US08426080B2 Gas replacement method of fuel cell, fuel cell system and device for fuel cell system
A method of replacing a gas in a fuel cell system is provided, which comprises the steps of detecting that a fuel cartridge is connected to the fuel cell system having a fuel cell and supplying a fuel from the fuel cartridge on the basis of the detection to start replacement of gas in the fuel cell system. Thereby, a simple gas replacement method is provided for replacing the gas other than the fuel, which has entered the fuel cell system that is supplied with the fuel from the fuel cartridge, with the fuel. Especially, a user does not have to perform the gas replacement operation manually. The gas replacement can be automatically performed.
US08426078B2 Manufacturing of fuel cell membrane electrode assemblies incorporating photocurable cationic crosslinkable resin gasket
A first transport system moves a web comprising a subgasketed CCM layer and an application system applies a crosslinkable resin to at least a subgasketed portion of the subgasketed CCM layer. The crosslinkable resin preferably comprises a photocurable cationic crosslinkable resin. A first curing apparatus subjects an exposed surface of the crosslinkable resin to a photo curing process to initiate curing of the crosslinkable resin. A second transport system moves a GDL into adhering contact with a partially cured exposed surface of the crosslinkable resin of the CCM layer so as to form an MEA layer. A second curing apparatus subjects the GDL, partially cured crosslinkable resin, and CCM layer structure to a thermal curing process to substantially complete curing of the crosslinkable resin. A converting system is configured to receive the MEA layer and produce a plurality of discrete MEAs from the MEA layer.
US08426077B2 Proton conductors
Proton conductivity has been shown in acceptor-doped rare earth orthoniobates and tantalates (LnNbO4 and LnTaO4) at high temperatures and in a humid atmosphere. The use of the materials as an electrolyte in a laboratory-scale fuel cell and water vapor sensor has been demonstrated. Results for Ca-doped LaNbO4 are given as examples.
US08426076B2 Fuel cell
A fuel cell includes a membrane electrode assembly (MEA), a fuel delivery system distributing fuel to an anode side of the MEA, and a flow distributor delivering an oxidizer to a cathode side of the MEA. The flow distributor includes at least one serpentine channel through which the oxidizer is delivered to the cathode side of the MEA. Each portion of the serpentine channel delivers oxidizer to a portion of the cathode side of the MEA in contact, directly or through a porous diffuser, with the channel portion. The channel portion transfers water with the portion of the MEA in contact with the channel portion and also transfers water between adjacent channel portions via a water-permeable, gas impermeable material that defines at least a portion of the channel.
US08426074B2 Solid oxide fuel cell
A solid oxide fuel cell capable of extending the time period over which initial rated output power is maintained, while restraining increases in running cost. The present invention is a solid oxide fuel cell (1), having a fuel cell module (2) furnished with multiple fuel cell units, a fuel supply device (38), an oxidant gas supply device (45), and a controller (110) for controlling the amount of fuel supplied; the controller is furnished with a degradation determining circuit (110a) for determining degradation, and a fuel correction circuit (110b) for correcting the fuel supply amount based on the degradation determination; when it is determined that the fuel cell module has degraded, the fuel correction circuit executes a correction so that rated output power is maintained, and when the predetermined correction switching condition is satisfied, the fuel correction circuit executes a correction to reduce the fuel cell module rated output power.
US08426071B2 Method and apparatus for separating liquid from a gas stream
An apparatus for separating liquid from a gas stream. The apparatus includes an elongated housing having a cylindrical inner surface and a gas stream inlet that is tangential to the side wall of the housing so as to cause the entering gas stream to swirl within the housing. A gas stream outlet is located at the top of the housing and a liquid outlet at the bottom. The gas stream outlet can include an elongated tubular member that extends into the housing and has an opening that is located below the housing gas stream inlet. Liquid components of the gas stream separate from the stream under the influence of centrifugal forces that are created by the swirling flow path of the stream within the housing. A liquid outlet and liquid outlet valve are provided for maintaining a minimum level of liquid within the housing so as to maintain a liquid seal within the housing. A level indicator may optionally be provided to monitor the liquid level within the housing. A power generation apparatus having two or more of the separators for separating liquid from fuel cell and fuel processor streams. Methods for manufacturing an apparatus for removing liquid from a gas stream and methods for separating liquid from a gas stream are also provided.
US08426069B2 Battery having a belt-like separator
A battery of this invention includes: a separator which is folded in a zigzag manner, thereby forming a layered structure having at least one first-electrode holding part and at least one second-electrode holding part which are alternately aligned; a first electrode accommodated in the first-electrode holding part; and a second electrode accommodated in the second-electrode holding part. At least one of the first electrode and the second electrode has at least one protruding part. The first electrode is connected to a first terminal, and the second electrode is connected to second terminal.
US08426068B2 Metal foil for secondary battery and secondary battery
A metal foil for secondary battery generating less cutting chips at the time of forming an opening and allowed to have a higher aperture ratio without reducing strength and a secondary battery in which short circuit caused by generation of electrode debris can be suppressed are provided. A metal foil 1 for secondary battery is provided with a metal thin plate 2, plural first convex portions 3A formed on a first principal surface 2a of the thin plate 2 by plastic forming and plural second convex portions 3B formed on a second principal surface 2b opposite to the first principal surface 2a by the plastic forming, wherein the convex portions 3A and 3B each have an opening 31 of which aperture plane 31a is orthogonal or substantially orthogonal to the principal surfaces 2a and the 2b.
US08426064B2 Composite material for positive electrode of lithium battery
The present invention provides a composite material for positive electrodes of lithium batteries, which provides a lithium battery having excellent high rate electrical discharge characteristics, has a sufficiently secured diffusion passage for Li, and has high conductivity, a process for producing the same, as well as a positive electrode and a battery using the composite material for positive electrodes of lithium batteries. The present invention relates to a composite material for positive electrodes of lithium batteries, comprising composite particles containing positive electrode active material particles and fibrous carbons, wherein the composite particles have a form in which the positive electrode active material particles are supported by the fibrous carbons.
US08426061B2 Nitride and carbide anode materials
Described is an anode material which is a transition metal nitride or carbide in form of nanoparticles, preferably a nitride or carbide with one nitrogen or carbon per metal, and especially a nitride or carbide having rock salt structure. A preferred anode material is vanadium nitride, in particular carbon coated vanadium nitride having a mean particle size of <500 nm. Embedded in an electrically conducting environment, such nanoparticulate material, in particular the vanadium nitride shows exceptional good charging-discharging cycle stability.
US08426059B2 Electrochemical cell having an electrically insulated housing
An electrochemical cell including a housing configured to receive a cell element. The housing has an electrically-insulating material including metal oxide particles provided on at least a portion of an inner surface thereof to prevent electrical contact between the housing and the cell element. A method of manufacturing an electrochemical cell including applying an electrically-insulating material including metal oxide particles to an inner surface of a housing for an electrochemical cell and inserting a cell element into the housing.
US08426058B2 Metal-resin composite and method
A metal-resin composite comprises a metal substrate with concavities in the surface, a first coating layer on the surface of the metal substrate, a second coating layer on the first coating layer, and a third coating layer on the second coating layer. The first coating layer fills the concavities and covers the surface of the substrate.
US08426056B2 Power supply device
A power supply device, which is simply assembled and in which a cell assembly and a measuring section are freely inserted and detached, is provided. A power supply device 1 includes a cell assembly 2, a plurality of first bus bars 51, a plate 3 to which the plurality of bus bars 51 are attached. The plate is overlapped on the cell assembly 2. The cell assembly 2 has a plurality of cells 21 respectively including positive electrodes 23 at one ends and negative electrodes 24 at the other ends. The first bus bars 51 connect the positive electrodes 23 of the one cells 21 to the negative electrodes 24 of the other cells 21 of the cell assembly 2 which are mutually adjacent when the plate 3 is overlapped or overlaid on the cell assembly 2. The power supply device 1 includes a positioning unit 71 that relatively positions the cell assembly 2 to the plate 3 and a guide unit 72 that guides the plurality of first bus bars 51 to positions where the first bus bars 51 connect the respectively corresponding positive electrodes 23 to the negative electrodes 24 when the plate 3 is attached to the cell assembly 2.
US08426054B2 Laminated porous film and separator for cell
A laminated porous film having a shutdown (SD) property and a high breakdown (BD) property combined includes at least two layers, which are a porous membrane layer (A layer) having a thickness of 10 μm or greater other than non-woven fabric and a non-woven fabric layer (B layer) having a fiber diameter of 1 μm or less. A value of the ratio (AP1/AP2) between air permeability when heating at a heating temperature of 150° C. to 200° C. for three minutes (AP1) and air permeability prior to heating (AP2) is 10 or greater at any heating temperature between 150° C. and 200° C.
US08426052B2 Li-ion battery with porous anode support
An electrochemical cell in one embodiment includes a first electrode, and a second electrode spaced apart from the first electrode, the second electrode including, a current collector, an electrically conducting rigid support frame electrically connected to the current collector, and an active material coated to the rigid support frame.
US08426050B2 Battery module having cooling manifold and method for cooling battery module
A battery module having a cooling manifold is provided. The battery module includes a plurality of battery cell assemblies having a plurality of heat exchangers. The battery module further includes the cooling manifold operably coupled to the plurality of battery cell assemblies. The cooling manifold has a manifold portion and a cover plate. The manifold portion has a peripheral wall, a rear wall coupled to the peripheral wall, and a flow diverter. The peripheral wall has a top portion with an inlet aperture extending therethrough. The rear wall has a plurality of outlet apertures extending therethrough. The cover plate is coupled to the peripheral wall opposite to the rear wall. The flow diverter extends from the rear wall and is disposed below the inlet aperture. The flow diverter is configured to receive fluid from the inlet aperture and to divert the fluid so that a substantially equal flow rate of the fluid is obtained through each outlet aperture of the plurality of outlet apertures to a respective heat exchanger of the plurality of heat exchanger for cooling the plurality of battery cell assemblies.
US08426048B2 Battery pack, electronic apparatus equipped with the same and electronic apparatus equipped with battery housing part
A battery pack including at least a battery and a casing for accommodating the battery, in which the casing has a ventilation hole communicating with the outside of the casing, and a mesh member made of metal for covering at least the ventilation hole is provided at the side surface of the casing. Preferably, the mesh member is coated with an insulating resin.
US08426047B2 Multi-series battery control system
A multi-series battery control system comprises battery cell groups each having a plurality of serially connected battery cells, a plurality of integrated circuits each disposed in correspondence to one of the battery cell groups and a battery control device that exchanges signals with the individual integrated circuits. Each integrated circuit includes an address setting means that receives a message unique to the integrated circuit, different from messages sent to other integrated circuits, from the battery control device, writes over an initialized address of the integrated circuit with the message and alters the message to a message with which an initialized address of another integrated circuit cannot be overwritten in a step assigned with an ordinal number matching the position of the integrated circuit with regard to the connection order.
US08426043B2 Boron suboxide composite materials
The invention provides a boron suboxide composite material comprising boron suboxide and a secondary phase, wherein the secondary phase contains a boride. The boride may be selected from the borides of transition metals of the fourth to eighth groups of the periodic table. Particularly, the boride may be selected from the borides of iron, cobalt, nickel, titanium, tungsten, hafnium, tantalum, zirconium, rhenium, molybdenum or chromium. The boride also may be a platinum group metal boride, preferably palladium boride. The secondary phase also may contain one or more oxides.
US08426034B2 Light-emitting element, light-emitting device, and electronic appliance
The cluster is formed in such a way that two molecules of arylamine compounds in each of which two arylamines each having one phenyl group and two aryl groups bonded with a nitrogen atom form a bisphenyl bond through the respective phenyl groups are arranged in parallel, thereby forming a dimolecular body and that the dimolecular body is coordinated to metal oxide. The light-emitting element has a layer including the cluster. A manufacturing method thereof includes the steps of vaporizing simultaneously metal oxide and an arylamine compound in which two arylamines each having one phenyl group and two aryl groups bonded with a nitrogen atom form a bisphenyl bond through the respective phenyl groups under vacuum and solidifying simultaneously the vaporized metal oxide and arylamine compound.
US08426032B2 Composite articles made by process for joining stainless steel part and silicon carbide ceramic part
A process for joining a stainless steel part and a silicon carbide ceramic part comprising: providing a SUS part, a SiC ceramic part, a Mo foil and a Ni foil; depositing a nickel coating on a surface of the SiC ceramic part; placing the SiC ceramic part, the Mo foil, the Ni foil, and the SUS part into a mold, the Mo foil and the Ni foil located between the SiC ceramic part and the SUS part; placing the mold into a chamber of an hot press sintering device, heating the chamber and pressing the SUS part with the nickel coating, the SiC ceramic part, the Mo foil, and the Ni foil at least until the SUS part, the SiC ceramic part, the Mo foil and the Ni foil form a integral composite article.
US08426029B2 Metallic laminate and method for preparing the same
The present invention provides a metallic laminate and a method for preparing the same. The metallic laminate includes a metal layer, and at least one polymide resin layer. The polymide resin layer has a modulus of elasticity of 70 Mpa at 400° C.
US08426027B2 Composition for coating plastic substrate, coating film formed therefrom, and formed body
The present invention relates to a composition for coating a plastic substrate, a coating film formed therefrom and a molded body. The composition can form a coating film that exhibits favorable adhesion to plastic substrates, as well as excellent abrasion resistance and weather resistance. The coating film-forming components of the composition include silica particles having (meth)acryloyl groups, a hexafunctional or higher aliphatic urethane(meth)acrylate, and an active energy beam-curable compound having an alicyclic structure, wherein the amount of the silica particles is within a range from 1.0 to 40 mass %, relative to 100 mass % of the coating film-forming components.
US08426022B2 Coated leather
A coated leather, in particular split cowhide leather, has a preferably nubuck-like appearing surface structure. The coating is formed with a surface layer formed with a mechanically and moisture-stable polymer and bonded to the surface of the leather or split leather by a polymer-based bonding layer. The outer layer is notable for inner smoothness and is formed with soft polyurethane. It includes in the non-embossed region microdepressions which are essentially closed in the direction of the leather but are open towards the outside, have an internal width of less than 130 μm and are arranged close-packed to each other in the manner of soapy foam cells. The microdepressions are each separately bounded by thin mutually crosslinked stays which have on the outside a matt or finely fibrous fine-roughness structure surface, and have an essentially semispherical-shaped concave inner surface which faces outward and is smooth. The coating may include two or more layers that are riveted to each other by way of pins or the like that are anchored in pores.
US08426021B2 D 1364 BT secondary coatings on optical fiber
The invention relates to a Radiation Curable Secondary Coating composition for use on an Optical Fiber. The Radiation Curable Secondary Coating composition is a urethane-free Alpha Oligomer prepared by reaction of the following: (a) an acrylate compound selected from an alcohol-containing acrylate or alcohol-containing methacrylate compound, (b) an anhydride compound, (c) an epoxy-containing compound, (d) optionally an extender compound, and (e) optionally a catalyst. The invention also relates to a coated wire and to a coated optical fiber.
US08426011B2 Marking based on chiral liquid crystal polymers
A liquid crystal polymer marking is obtainable by a process that comprises applying a chiral liquid crystal precursor composition onto a substrate, heating the composition to a bring same to a chiral liquid crystal state, locally applying at least one modifying agent to modify the chiral liquid crystal state, and curing and/or polymerization the resultant product. This abstract is neither intended to define the invention disclosed in this specification nor intended to limit the scope of the invention in any way.
US08426010B2 Structural element
A structural element includes a continuous layer comprising a set of first main-faces defining a first surface and a set of second main-faces defining a second surface and the continuous layer extending between the first surface and the second surface, wherein along a first direction, the first main-faces and the second main-faces alternate in order and are connected by first side-faces, along a second direction different from the first direction, the first main-faces and the second main-faces alternate in order and are connected by second side-faces, and along a third direction different from the first direction and different from the second direction, a pair of neighboring first main-faces is connected by a first bridge-face, and the first bridge-face is connected to neighboring second main-faces by first bridge-side-faces.
US08426006B2 Method for manufacturing an object from a sandwich structure having a reinforced corner and an object of this type
An exemplary method for manufacturing and reinforcing a corner in an object made from a sandwich structure, having a thermoplastic core layer (18), which is arranged between two cover layers (16), at least one of which is a plastic cover layer, which method includes the steps of: producing an object including a corner between two object parts; positioning a thermoplastic core part (24) and an additional fiber-reinforced thermoplastic layer (26) in the corner, which thermoplastic core part has a shape adapted to the corner, in such a manner that the additional fiber-reinforced thermoplastic layer (26) substantially covers the exposed surface of the core part (24); and connecting a cover layer (16) of the sandwich structure to the additional fiber-reinforced thermoplastic layer (26).
US08426005B2 Optical information recording medium
A super-resolution optical information recording medium comprises a super-resolution layer and a recording layer which are laminated on a support substrate, wherein the super-resolution layer is provided with properties consisting of a first state to maintain a solid phase against irradiation of a laser beams, and a second state to become a liquid layer state against irradiation of a laser beam onto a recording mark on the recording layer to thereby change an optical constant. The optical constant is determined so that a ratio of a super-resolution signal intensity obtained at a second state region against a background light interference intensity obtained at a first state region is at least 1.8, and a ratio of the super-resolution signal intensity obtained at the second state region against a disk noise intensity obtained at first and second state regions is at least 0.16.
US08426001B2 Welding alignment and spacing article
A welding alignment and spacing article is provided for forming a welding gap between two structures to be welded together. The article includes a body having first and second surfaces that are spaced from each other at a selected spacing distance to define a region of selected body thickness. The body is formed from a non-metallic degradable body material in the region that can be wholly or partially degraded by exposure to a degrading agent to reduce the body thickness. The body is also formed from a non-degradable body material in the region. The degradable body material and the non-degradable body material are sufficiently incompressible to be useable as a spacer that maintains a specified welding gap distance between the two structures to be welded.
US08426000B2 Customizable container identification device
The present disclosure provides a container identification device including a protective top layer having a top surface and a bottom surface, and a marking layer secured to the bottom surface of the protective top layer, wherein a mark is made on the marking layer when a corresponding impression is made on the protective top layer. The container identification device further includes an adhesive layer secured to the marking layer.
US08425998B2 Fixing system
A fixing system has at least one adhesion closure part (9) which can be fixed by its fixing side (7) onto the free side (19) of a fixing part (11). The other functional side of the fixing part is at least partially provided with an active substance (15) which can be activated. When activated, the substance forms a fixing connection with the fixing side (5) of a third part (1,3).
US08425997B2 Cobalt bearing polymeric compositions
The invention relates to polymeric cobalt bearing compounds, in particular for use as metal-rubber adhesion promoters (RAPs) in tires, belts and hoses. Known active substances are a.o. cobalt stearates, naphthenates, resinates, decanoates, boro-decanoates and many other forms of acylates. While these substances appear to enhance the metal-rubber adhesion, all of them also come with significant drawbacks, a.o. linked to the relatively high bioavailability of cobalt in these substances. The invention concerns more particularly a polymer comprising Co-carboxylate sequences, with a Co content of at least 3% by weight, and with a mean molecular weight of more than 2000. Several synthesis methods, allowing to reach relatively high Co concentrations in the polymer, illustrate the invention. The invented polymers show a strongly reduced bioavailability of Co compared to currently available products, as demonstrated by aqueous leaching tests. As RAPs, they perform similarly to commercial products, as shown by pullout tests.
US08425996B2 Indicators for detecting the presence of metabolic byproducts from microorganisms
Polymeric indicator films and pH indicating wraps are provided for visually monitoring, detecting, and/or determining the presence of metabolic byproducts from harmful or potentially harmful microorganisms. Also provided are methods of use and preparation of the polymeric indicator films.
US08425995B2 Disposable yard debris bundling device with drawstrings
A high strength disposable debris bundling device including a sheet-like main body having a plurality of drawstrings running generally parallel and in spaced relation through separate channels associated with the wrap. The drawstrings preferably comprise elongate flexible thin rope or cord-like structures that run through hem channels formed in the wrap and function to compact and secure the debris in bundle with the wrap disposed in surrounding relation therewith. Providing at least 4 drawstrings allows the wrap to be pulled tightly around the debris and secured in contoured surrounding relation therewith. The wrap preferably has a length of approximately 4.0 feet so as to conform to modern trash removal standards and regulations. Handles are provided to assist in handling the wrapped debris bundle.
US08425994B2 Web and method for making fluid filled units
A preformed web and a method of producing dunnage units from the preformed web. The web is an elongate flattened thermoplastic tube having an inflation edge and an opposite edge. The tube includes spaced transverse seals that define sides of pouches. In one embodiment, the web is configured such that a gap forms between each pair of adjacent pouches when the pouches are inflated. In one embodiment, an inflation edge of the web comprises a frangible connection that allows the inflation edge to be broken by an unsharpened object.
US08425992B2 Continuous diorama
Diorama having a focal zone and a plurality of inclined panels on which different areas of a two-dimensional image are displayed. The panels are disposed about the focal zone, which can be an area, a line, or a point, and the image flows continuously between the panels with no physical seams between areas of the image displayed on adjacent ones of the panels. The panels are rotated away from a seam line that extends between the focal zone and an outer edge of the image, and outwardly diverging edges of the panels along edges of the image created by the rotation are brought together along the seam line to tilt the panels to their inclined positions and create an enhanced perspective effect.
US08425989B2 Photoalignment material and method of manufacturing display substrate using the same
A photoalignment material and a method of manufacturing of a display substrate using the photoalignment material are disclosed. The photoalignment material includes a photoalignment polymer, a photoalignment additive, and an organic solvent. When the photoalignment additive is used, a side reaction due to ultraviolet (UV) light may be prevented, and the stability of alignment layer may be improved.
US08425987B2 Surface charge enhanced atomic layer deposition of pure metallic films
A method including applying an electric charge to a substrate in a chamber; introducing an organometallic substituent into the chamber, the organometallic substituent including a metal ligand and an organic ligand; and depositing a metal film by reducing the metal ligand of the organometallic substituent. A method including applying a removable electric charge to a substrate; in the presence of the applied electric charge, introducing an organometallic substituent into the chamber, the organometallic substituent including a metal ligand and an organic ligand; and depositing a metal film by reducing the metal ligand of the organometallic substituent. A method including introducing an organometallic substituent into the chamber, the organometallic substituent including a metal ligand and an organic ligand; and depositing a metal film by reducing the metal ligand of the organometallic substituent with an externally applied electric charge.
US08425986B2 Composite nanostructure solid acid fuel cell electrodes via electrospray deposition
The present invention provides a method of preparing a nanostructure material on a substrate. The method includes spraying an aqueous solution from a capillary to the substrate, wherein the aqueous solution includes an electrolyte and an alcohol. The method also includes applying an electrical bias between the capillary and the substrate, such that the electrolyte deposits on the substrate forming the nanostructure material. The present invention also provides the nanostructure material prepared by this method.
US08425984B2 Multilayer film and manufacturing method thereof
According to a manufacturing method of a multilayer film according to one aspect of the present invention, at the step of applying a coating liquid prepared by dissolving a plurality of monomers or polymers in at least one solvent onto a substrate and subsequently drying the coating liquid, the solvent is allowed to penetrate into the substrate at a specified speed. This causes concentration distribution of the solvent within the coated layer in the thickness direction thereof, and thus a multilayer film separated into an upper layer and a lower layer can be formed by one coating. Accordingly, a multilayer film having a different function in each layer can be formed by one coating.
US08425982B2 Methods of improving long range order in self-assembly of block copolymer films with ionic liquids
Methods for fabricating arrays of nanoscaled alternating lamellar or cylinders in a polymer matrix having improved long range order utilizing self-assembling block copolymers, and films and devices formed from these methods are provided.
US08425979B2 Maskant free diffusion coating process
Selected areas of a component are covered with a maskant chamber during a coating process to protect the areas from the coating vapor. The covered areas are further protected by a flow of an inert gas in the maskant chamber.
US08425977B2 Substrate processing chamber with off-center gas delivery funnel
Methods and apparatus for processing substrates are disclosed herein. The process chamber includes a chamber body, a substrate support pedestal, a pump port and a gas injection funnel. The chamber body has an inner volume and the substrate support pedestal is disposed in the inner volume of the chamber body. The pump port is coupled to the inner volume and is disposed off-center from a central axis of the substrate support pedestal. The pump port provides azimuthally non-uniform pumping proximate to a surface of the substrate support pedestal and creates localized regions of high pressure and low pressure within the inner volume during use. The gas injection funnel is disposed in a ceiling of the chamber body and opposite the substrate support pedestal. The gas injection funnel is offset from the central axis of the substrate support pedestal and is disposed in a region of low pressure.
US08425969B2 Cooking oil composition with additive to reduce oil absorption
An extract derives from plant parts of Rutaceae plant family to be incorporated into a cooking oil composition for reducing oil adsorption into food fried in the cooking oil composition thereof.
US08425963B2 Method for extracting a beverage from a capsule
The invention relates to a device for extracting a cap (16) having a first part (2), a second part (3) which is movable with respect to the second part (2) which is provided with a space for the cap and defines the cap extracting position in a closed position thereof, an introduction and positioning part having the cap guiding elements (6, 7) which are arranged in such a way that it is possible to insert the cap by gravity force and position it in an intermediate position and a beverage pouring system (19) in which the second movable part (3) displaces the cap from the intermediate position to the extraction position.
US08425959B2 Apparatus and process for producing a dough product topped with assorted toppings and a dough product
Apparatus and process for producing a flat dough product, in particular a pizza, topped with assorted toppings, is provided with a plurality of topping dispensers and at least one movable positioning mechanism, which is provided vertically below a plane spanned by the topping dispensers and to which a dough carrier is associated which may be supported such that it can rotate; the positioning mechanism actuated by an actuating mechanism to position the dough carrier underneath a topping dispenser to allow topping to be dispensed. The topping dispensers are arranged in a matrix configuration, distributed in two mutually perpendicular spatial directions x,y and the positioning mechanism is configured for positioning the dough carrier in the two mutually perpendicular spatial directions x,y corresponding to the matrix configuration. The topping dispensers are actuated passively to dispense topping by rotating the dough carrier and/or by means of the lifting mechanism.
US08425954B2 Canna and Shea topical cream
A THC composition comprises cannabis leaves simmered in butter, which is then filtered and cooled, and then mixed with shea butter. The resulting compound is used for topical skin relief, sun protection for skin and other uses. The butter used for simmering the cannabis leaves may be cow butter, sheep butter, olive oil, cooking oil, and other compositions.
US08425953B2 Extract of Coptidis rhizoma and novel use thereof in treating respiratory disease
A composition for suppressing cough, removing sputum, preventing and/or treating a respiratory disease comprising an extract of Coptidis rhizoma or a combined extract of Coptidis rhizoma with ivy leaf as an active ingredient, and a method of suppressing cough, removing sputum, and/or preventing and/or treating respiratory disease using the composition, are provided.
US08425950B1 Liquid mixture and methods for use
A method of relieving pain includes topically applying a liquid mixture to an area of human skin. The liquid mixture includes an alcohol including concentrated ethanol, and at least one of a cannabis leaf, a cannabis stem, or a combination thereof. The method also includes absorbing the liquid mixture through the skin, providing reduced inflammation to the area, and providing increased blood flow to the area.
US08425947B2 Fibrinogen-based tissue adhesive containing an elastase inhibitor
The present invention provides a fibrinogen-based tissue adhesive which contains an elastase inhibitor.
US08425942B2 Method for sterilizing unheated raw honey, a honey-based wound care preparation, a wound care treatment product, and a biscuit based on honey
The invention relates to a method for sterilizing raw, unheated honey, wherein the raw, unheated honey is sterilized by ozonizing it by using an ozone generator. The invention also relates to a honey-based wound care preparation, wherein said preparation comprises raw, unheated ozonized honey that has been ozonized by a method according to the invention. The invention also relates to a wound care treatment product comprising a honey-based preparation, wherein the said wound care treatment product comprises a preparation according to the invention. Finally, the invention relates to a biscuit based on honey and food fibers and/or by-products of food fibers, wherein the biscuit is prepared from ozonized food fibers and/or by-products of food fibers and raw, unheated ozonized honey that has been ozonized by a method according to the invention.
US08425941B2 Powder cosmetic composition
A powder cosmetic composition having satisfactory usability, cosmetic durability, adhesion properties to the skin, slip properties and smoothness comprising, as powder components (a) and (b): (a) a branched alkyl silicone-treated powder and (b) a composite silicone elastomer powder coated on all or part of the powder surface with at least one coating selected from the group consisting of clay minerals, resins, metal oxides and salts, in particular including 3 to 80 mass % of the component (a) and 1 to 30 mass % of the component (b).
US08425939B2 Remedy
It is intended to provide a remedy for diseases caused by macrophages with dysfunction or mediated by macrophages. Namely, a remedy which activates the phagocytic capacity of macrophages and thus is efficiently incorporated into the macrophages due to the vigorous phagocytosis. As a result, the macrophages with dysfunction are normalized, macrophages infected with a pathogen are exterminated or a pathogen in the infected macrophages is exterminated.
US08425937B2 Pharmaceutical compositions for glucocorticoid replacement therapy
The invention relates to glucocorticoid replacement therapy and provides pharmaceutical compositions and kits designed to deliver one or more glucocorticoids to a subject in need thereof in a manner that results in serum levels of the glucocorticoid that essentially mimic that of a healthy subject for a clinically relevant period of time. The pharmaceutical composition comprises one or more glucocorticoids, wherein a first part of one or more glucocorticoids is substantially immediately released and a second part of one or more glucocorticoids is released over an extended period of time of at least about 8 hours, and the amount of the one or more glucocorticoids of the first part, expressed as hydrocortisone equivalents, is in a range of from about 15 to about 50% of the total hydrocortisone equivalents. The invention also relates to a kit comprising a first and a second component, the first component designed to release one or more glucocorticoids substantially immediately and the second component is designed to release one or more glucocorticoids over an extended period of time of at least 8 hours. The invention also relates to a method for treating diseases requiring glucocorticoid treatment such as in subjects having a glucocorticoid deficiency disorder. In another aspect the invention relates to the use of a first and a second amount of one or more glucocorticoids for the preparation of a pharmaceutical composition or kit for the treatment of a glucocorticoid deficiency disorder.
US08425936B2 Antibiotic product, use and formulation thereof
An antibiotic product is comprised of at least three dosages forms, each of which has a different release profile, with the Cmax for the antibiotic product being reached in less than about twelve hours. In one embodiment, there is an immediate release dosage form, as well as two or more sustained release dosage forms, with each of the dosage forms having a different release profile, wherein each reaches a Cmax at different times.
US08425933B2 Abuse-resistant oral dosage forms and method of use thereof
An opioid-antagonist oral dosage form which does not release a therapeutically effective amount of the opioid antagonist when the oral dosage form is orally administered to a human being, but whereby a physical alteration of the oral dosage form results in a release of the therapeutically effective amount of the opioid antagonist. An embodiment of the oral dosage form includes an opioid-antagonist layer coated onto a biologically inert pellet, and a non-releasing membrane coated onto the opioid-antagonist layer. Optionally, the oral dosage form can also include an opioid agonist, such that a method of preventing the abuse of an oral dosage form of an opioid agonist is provided by forming the oral dosage form including an opioid agonist and an opioid antagonist.
US08425931B2 Biodegradable hyaluronic acid derivative
The description provides a biodegradable hyaluronic acid derivative including at least one modified hyaluronic acid repeating unit represented by the formula (HA)-[O(C═O)NH-M]p, wherein HA is a unit including N-acetyl-D-glucosamine and D-glucuronic acid, M is a modifying moiety containing a C2-16 hydrocarbyl group, and p is an integer of 1 to 4.
US08425922B2 Adjuvant compositions and methods of use
This disclosure provides adjuvant compositions that are capable of modulating the immune response in a subject. These adjuvant compositions may also be used enhance the immunogenicity of antigens. Also provided are methods of making the adjuvant compositions as well as methods of using the adjuvant compositions.
US08425916B2 Immunizing compositions and methods of use
The present invention provides compositions including siderophore receptor polypeptides and porins from gram negative microbes, and preferably, lipopolysaccarhide at a concentration of no greater than about 10.0 endotoxin units per milliliter. The present invention also provides methods of making and methods of using such compositions.
US08425914B2 Methods for enhanced somatostatin immunogenicity in the treatment of obesity
Compositions and methods are provided for treatment growth hormone and/or insulin-like growth factor 1 deficiency in a patient in need of such treatment. Compositions and methods include novel vaccines that provide immunogenicity for somatostatin and result in the increased release of endogenously produced growth hormone and/or insulin-like growth factor 1.
US08425913B2 Immunogenic agents against Burkholderia pseudomallei and/or Burkholderia mallei, comprising lipopolysaccharide, capsular polysaccharide and/or proteins from Burkholderia pseudomallei
An immunogenic agent which comprises a killed strain of Burkholderia pseudomallei, or a combination of components thereof which combination produces a protective immune response in an animal to whom it is administered, and which comprises at least two members selected from the group consisting of (i) a lipopolysaccharide of Burkholderia pseudomallei, (ii) a capsular polysaccharide of Burkholderia pseudomallei and (iii) a protein of Burkholderia pseudomallei or an immunogenic variant thereof or an immunogenic fragment of either of these, or a nucleic acid which expresses said protein, immunogenic variant or immunogenic fragment thereof in a host animal; for use in the prevention or treatment of infection by Burkholderia pseudomallei and/or Burkholderia mallei.
US08425912B2 Immunoconjugates with an intracellularly-cleavable linkage
The invention relates to therapeutic conjugates with improved ability to target various cancer cells containing a targeting moiety and a therapeutic moiety. The targeting and therapeutic moieties are linked via an acid cleavable linkage that increases therapeutic efficacy of the immunoconjugate.
US08425911B2 Methods of treating secondary bone tumors with antibodies against PDGFR alpha
The invention provides methods of treating bone cancer, particularly metastatic bone cancer, by administering a PDGFR alpha antagonist. The invention further provides methods of treating a mammal with a neoplastic disease using the antibodies alone or in combination with other agents.
US08425907B2 Methods for treating pruritus by administering an antibody that specifically binds human PAR2
The present invention provides methods for treating pruritus by blocking human protease activated receptor-2 (PAR2) activity. The methods of the invention can be used to treat pruritus associated with atopic dermatitis, psoriasis, burn scarring, hypertrophic scarring, keloids, renal failure or hepatic failure. The methods of the invention include administering an antibody or antigen-binding fragment thereof that specifically binds human PAR2.
US08425905B2 Antibodies directed against amyloid-beta peptide and methods using same
Monoclonal antibody 9TL and antibodies derived from 9TL directed against amyloid-beta peptide and methods of using same for diagnosing and treatment of Alzheimer's disease and Aβ peptide associated diseases are described. Methods of using antibodies directed against amyloid-beta peptide having impaired effector function for treatment of Alzheimer's disease and Aβ peptide associated diseases are also described.
US08425903B2 Methods of treatment by administering antibodies to notch receptors
The present invention relates to Notch-binding agents and Notch antagonists and methods of using the agents and/or antagonists for treating diseases such as cancer. The present invention provides antibodies that specifically bind to a non-ligand binding region of the extracellular domain of one or more human Notch receptor, such as Notch2 and/or Notch3, and inhibit tumor growth. The present invention further provides methods of treating cancer, the methods comprising administering a therapeutically effective amount of an antibody that specifically binds to a non-ligand binding region of the extracellular domain of a human Notch receptor protein and inhibits tumor growth.
US08425902B2 Monoclonal antibodies against claudin-18 for treatment of cancer
The present invention provides antibodies useful as therapeutics for treating and/or preventing diseases associated with cells expressing CLD18, including tumor-related diseases such as gastric cancer, esophageal cancer, pancreatic cancer, lung cancer, ovarian cancer, colon cancer, hepatic cancer, head-neck cancer, cancer of the gallbladder, and the metastases thereof.
US08425897B2 Compositions containing LAG-3 and cells that secrete GM-CSF and methods of use
The present invention relates to a method of enhancing anti-tumor protection in a mammal. More particularly, the invention is concerned with combinations comprising antigen presenting cell (APC) activators and a cytokine-secreting cell and methods of administering the combination for enhanced immune response to tumor cells in a patient with a cancer.
US08425896B2 Treatment of tumors with recombinant interferon alpha
This invention provides a recombinant super-compound interferon or an equivalent thereof with changed spatial configuration. The super-compound interferon possesses anti-viral or anti-tumor activity and therefore is useful to prevent and treat viral diseases and cancers. This invention also provides an artificial gene which codes for the super-compound interferon or its equivalent. Finally, this invention provides methods to produce recombinant super-compound interferon or its equivalent and various uses of said interferon.
US08425894B2 Use of oligomers of lactic acid in the treatment of gynaecological disorders
Use of the one or more oligomers of lactic acid with the following formula (I) wherein n is an integer from 2 to 25 such as, e.g., from 2 to 20, from 3 to 25, from 3 to 20, from 2 to 15, from 3 to 15, from 2 to 10, from 3 to 10, from 4 to 10, or from 4 to 9 or a lactic acid oligomeric product for the prophylaxis and/or treatment of a disease or condition that benefit of an acidic environment especially a gynaecological infection such as a bacterial infection, such as bacterial vaginosis, unspecific colpitis, senile colpitis, cervicitis, and urethritis, a fungal infection, such as candidosis (Candida albicans), cryptococcosis, actinomycosis, or a viral infection, such as Human Immunodefiency Virus (HIV), Herpes Simplex Virus (HSV), Human Papilloma Virus (HPV).
US08425889B2 Cleansing composition
There is provided a cleansing composition which has creamy foaming and excellent cleansing power, provides no stretched feeling of skin after rinsing and a refreshed feeling of skin, is excellent in storage stability and exhibits no reduction in physical properties, formation of precipitates and yellowing during a long-term storage period by combining N-acyl-aspartic acid or a salt thereof and N-acyl-diaspartic acid or a salt thereof, which have the same molecular structure of the N-acyl group, with a higher fatty acid or a salt thereof which has the same alkyl group as that of the above described N-acyl residue.
US08425884B2 O/W emulsified composition
The present invention provides an O/W emulsified composition excellent in formulation stability, feeling in use, and UV protection ability. The emulsified composition according to the present invention is an O/W emulsified composition, wherein (i) a first oil phase and (ii) a second oil phase are dispersed separately in an aqueous phase, (i) the first oil phase having average particle size of 700 nm or less, comprising an organic UV absorber, and being formed with, as an emulsifier, a polyoxyethylene/polyoxyalkylene alkyl ether block polymer represented by formula (1) or (2): R1O—(PO)m-(EO)n-H  (1) wherein R1 is a hydrocarbon group having 16 to 18 carbon atoms; PO is an oxypropylene group, EO is an oxyethylene group, and PO and EO are added to each other in block form; and m and n respectively represent average addition mole number of PO and EO, 70>m>4, 70>n>10, and n>m; and R2O-(AO)p-(EO)q-R3  (2) wherein R2 and R3 are either identical to or different from each other, and each of them is a hydrocarbon group having 1 to 4 carbon atoms; AO is an oxyalkylene group having 3 to 4 carbon atoms, EO is an oxyethylene group, and AO and EO are added to each other in block form; and p and q respectively represent average addition mole number of AO and EO, 1≦p≦70, 1≦q≦70, and 0.2<(q/(p+q))<0.8, and (ii) the second oil phase comprising a silicone oil and being formed with, as an emulsifier, an alkyl-modified carboxyvinyl polymer.
US08425877B2 Method for diagnosis of systemic sclerosis involving an anti-AT1-receptor antibody
The present invention relates to a method for diagnosis of a disease selected from the group of diabetes, vasculitis, collagenosis, an inflammatory rheumatic disease and arteriosclerosis wherein, presence or absence of an anti-AT1-receptor antibody is determined in a sample from a patient to be diagnosed and wherein, the presence of an anti-AT1-receptor antibody is indicative of the disease. The invention further relates to the use of an inhibitor of an anti-AT1-receptor antibody or an inhibitor of an AT1-receptor for the production of a medicament as well as plasmapheresis of blood for the removal of anti-AT1-receptor antibodies.
US08425876B2 Gene encoding a multidrug resistance human P-glycoprotein homologue on chromosome 7P15-21 and uses thereof
The invention relates to an MDR family P-glycoprotein located on human chromosome 7p15-21, polynucleotide sequences encoding this P-glycoprotein and fragments thereof. This gene is utilized in methods for assessing cancer cell susceptibility to therapies directed against multidrug resistance, and for the design of diagnostic and therapeutic methods relating to cancer multidrug resistance. The invention also relates to methods for determining whether a test compound may inhibit multidrug resistance.
US08425874B2 Process for the production of sulfur from sulfur dioxide with tail gas recycle
The reduction of the gas stream containing sulfur dioxide to elemental sulfur is carried out by reacting a reducing gas, such as natural gas, methanol or a mixture of hydrogen and carbon monoxide, with recycled sulfur and recycled tail gas to produce a stream containing hydrogen sulfide that may be reacted with the gas stream that contains sulfur dioxide. Gas streams with a molar concentration of sulfur dioxide from 1 to 100% may be processed to achieve nearly 100% sulfur recovery efficiency.
US08425870B2 Reduction of CO and NOx in full burn regenerator flue gas
A hot oxygen stream containing radicals is fed into a gas stream, such as a catalyst regenerator flue gas stream, that contains carbon monoxide to convert carbon monoxide to carbon dioxide.
US08425866B2 Control of emissions
Methods and apparatus utilizing chlorine dioxide and hydrogen peroxide are useful to reduce NOx emissions, as well as SOx and mercury (or other heavy metal) emissions, from combustion flue gas streams.
US08425865B2 Method of synthesizing pyrite nanocrystals
A method of synthesizing pyrite nanocrystals is disclosed which in one embodiment includes forming a solution of iron (III) diethyl dithiophosphate and tetra-alkyl-ammonium halide in water. The solution is heated under pressure. Pyrite nanocrystal particles are then recovered from the solution.
US08425863B2 Micro fluidic device
A micro fluidic device includes a valve/pump-unit with reduced dead volume having a substrate. The lower surface of the substrate includes two micro channels spaced apart by a valve area of the substrate that separates the two micro channels. A flexible membrane is arranged on the lower surface of the substrate facing an actuating element located in a through going cut-out of a cover element. Movement of the actuating element towards and away from the valve area of the substrate causes a pump and/or valve action of the flexible membrane area, respectively, to cause or stop a directed fluid flow between the two micro channels through a channel formed between the valve area of the substrate and the flexible membrane.
US08425859B2 Test strip card
The present invention relates to a test strip for determining and/or quantifying a property of a sample, such as the concentration of an analyte, the pH, the viscosity, or the specific gravity of a fluid specimen. More particularly, the present invention relates to an improved test strip and scale for determining and/or quantifying a property of a sample, such as the concentration of an analyte, the pH, the viscosity, or the specific gravity of a fluid specimen.
US08425858B2 Detection apparatus and associated method
An apparatus includes an article and a detector. The article includes a substrate, a faceted structure disposed on the substrate, and a sensor layer disposed on the faceted structure. The faceted structure is disposed on the substrate first surface and itself has a surface. The faceted structure surface has peripheral edge defining a diameter of the faceted structure surface. The sensor layer is disposed on the faceted structure surface. The sensor layer can react or can interact with a target species when the target species is sufficiently proximate to the sensor layer. The sensor layer responds to the reaction or to the interaction in a detectable manner. The detector detects a response to the reaction, or to the interaction, of the target species with the sensor layer.
US08425855B2 Reactor with silicide-coated metal surfaces
In an embodiment, a reactor includes a section, wherein at least a portion of the section includes a base layer, wherein the base layer has a first composition that contains a silicide-forming metal element; and a silicide coating layer, wherein the silicide coating layer is formed by a process of exposing, at a first temperature above 600 degrees Celsius and a sufficient low pressure, the base layer having a sufficient amount of the silicide-forming metal element to a sufficient amount of a silicon source gas having a sufficient amount of silicon element, wherein the silicon source gas is capable of decomposing to produce the sufficient amount of silicon element at a second temperature below 1000 degrees Celsius; reacting the sufficient amount of the silicide-forming metal element with the sufficient amount of silicon element, and forming the silicide coating layer.
US08425853B2 Plasma generation method and apparatus
A plasma generation apparatus and method, which achieve both sterilization and deodorization of attached bacteria even under the condition that steam or fine droplets of water are present. A pair of electrodes is prepared, plasma discharge is carried out by applying designated voltage between the pair of electrodes, fluid passage holes are provided at corresponding parts of respective electrodes so as to communicate with each other, and steam or fine droplets of water are applied to the fluid passage holes and plasma generated around the fluid passage holes.
US08425852B2 High concentration NO2 generating system and method for generating high concentration NO2 using the generating system
A high concentration NO2 gas generating system including a circulating path configured by connecting a chamber, a plasma generator, and a circulating means, wherein NO2 is generated by circulating a gas mixture including nitrogen and oxygen in the circulating path is provided. The high concentration NO2 gas generating system provides a high concentration NO2 generating system and the high concentration NO2 generating method using the generating system by which NO2 of high concentration (approximately 500 ppm or above) required for a high level of sterilization process in such as sterilization of medical instruments can be simply and selectively obtained. In addition, since indoor air is used as an ingredient, the management of ingredients is simple and highly safe, and the high concentration of NO2 can be simply and selectively prepared on demand.
US08425851B2 Exhaust emission control device
The invention has its object to provide an exhaust emission control device which can be favorably mounted on a vehicle without causing relative twisting between a particulate filter and a selective reduction catalyst. In the exhaust emission control device in which a particulate filter and a selective reduction catalyst are housed by casings, respectively, and arranged side by side such that inlet ends of the filter and the catalyst are oriented to one and the same direction, an S-shaped communication passage being provided for introduction of the exhaust gas from an outlet end of the filter to an inlet end of the adjacent catalyst through antithetical turnabout, urea water being addible intermediately of the communication passage, the casings for the filter and catalyst are integrally restrained by rigid plates (restraining members).
US08425849B2 Reclaiming apparatus
A reclaiming apparatus 106 includes: a sealed container 106a that is an absorbent reservoir for storing therein a part of an absorbent that has absorbed CO2 in flue gas, and a heater that heats the absorbent stored in the sealed container 106a. The reclaiming apparatus 106 distributes a part of the absorbent stored in the sealed container 106a, and brings the distributed absorbent into counter-current contact with steam. Because a part of the absorbent stored in the absorbent reservoir is brought into counter-current contact with the steam, absorbent component contained therein becomes volatilized, and is separated from depleted materials. In this manner, the absorbent component can be extracted from the depleted materials, and a loss of the absorbent can be reduced.
US08425847B2 Processes and apparatus for continuous solution polymerization
The disclosure provides a plant for the continuous solution polymerization of a feed comprising one or more olefin monomers in a solvent, e.g., hydrocarbon solvent, in which the plant comprises means for separating solvent from the polymer including a flash tank and a vacuum devolatilizer. The plant also includes in a first aspect stabilizer addition means for adding a stabilizer to the concentrated polymer fines at a location downstream of the flash and upstream of the vacuum devolatilizer. In another aspect the plant comprises means to add a molten stabilizer to the polymer at a location downstream of the reactors.
US08425843B2 Integrated apparatus and method to detect inflammatory states present in a sample of whole blood
Integrated apparatus and method for hematological analyses, wherein the apparatus, comprises, arranged substantially in line and integrated substantially in a single machine, a device (14) of the optical type to detect substantially instantaneously the speed of blood sedimentation (ESR) by measuring the optical density, or absorbance, of the blood sample, and a measuring assembly (18) with a cell-counter function or suchlike.
US08425840B2 Microchip and blood monitoring device
A microchip comprising therein a first channel which allows inflow of a first liquid selected from whole blood, platelet-rich plasma and a drug-treated liquid thereof, a second channel connected to the first channel, which allows inflow of a second liquid containing an agent that is reactive with the first liquid, and a merged channel extended from the connection portion of the first channel with the second channel, wherein, in the merged channel, a stirring section having a stirring bar for mixing the first liquid with the second liquid is provided; and a blood monitoring device using the same.
US08425836B1 Chromium alloy
A hypereutectic chromium alloy consisting of 9 to 12 at % tantalum, 4 to 15 at % silicon, 0 to 7 at % molybdenum, 0 to 7 at % aluminum, 0 to 7 at % titanium, 0 to 5 at % rhenium, 0 to 2 at % silver, 0 to 2 at % hafnium, 0 to 2 at % lanthanum, 0 to 2 at % cerium, 0 to 2 at % yttrium and the balance chromium and incidental impurities. The hypereutectic chromium alloy has good oxidation resistance and good fracture toughness. The chromium alloy may be used to make gas turbine engine turbine blades, turbine vanes, turbine seals, combustion chamber tiles, exhaust nozzle segments or steam turbine components.
US08425834B2 Method for producing clad material, and clad material
Provided are a method for producing a clad material, and a clad material which can prevent a brazing filler metal layer from having a higher melting point so as to prevent the strength degradation and thermal deformation of a metal material, which can reduce production costs, which can reduce in thickness the layer to prevent sagging of the brazing filler metal upon brazing and which can improve press formability. A powder press-fixing machine is used to press-fix metal powder to surfaces of a base material uncoiled from a coil by an uncoiler. In order to provide a required composition of brazing filler metal, at least two kinds of metal powder is mixed, the mixed powder being press-fixed to the base material to form the brazing filler metal layer, the brazing filler metal constituting the layer having the composition such that copper is added with at least phosphor to lower a melting point of the same relative to that of copper, thus producing the clad material.
US08425830B2 Permeable material, articles made therefrom and method of manufacture
The invention is directed to a honeycomb comprising cordierite and beta-spudomene, the honeycomb a having total porosity of greater than 30% and a mean pore diameter of less than 5 μm. The honeycomb is made from a mixture of activated kaolin and a mineral selected from the group consisting of lithium fluorhectorite, lithium hydroxyhectorite and mixtures thereof. In one embodiment up to 20 wt % SiO2, based on the total weight of the kaolin and minerals (fluarhectorite, hydroxyhectorite) is added and mixed therein prior to the formation of the green body. In another embodiment the amount of added SiO2 is up to 10 wt %. In one embodiment the total porosity is greater than 50% and the mean pore diameter is less than 5 μm.
US08425825B2 Apparatuses and methods for making seal rings for caps, and thus obtained seal rings
An apparatus for forming an object from plastics material includes a forming arrangement having a recess for forming an edge zone of the object, the recess extending around an internal region of the forming arrangement and a conduit cooperating with a piston device to supply the plastics material to the recess, the conduit leading into the internal region into a position contiguous with the recess.
US08425824B2 Process for producing hollow-fiber membrane filter element with a mixture of two-liquid mixing type curable resin
An object of the present invention is to provide a process for producing a mixture of a two-liquid mixing type curable resin, which process is hard to generate curing unevenness, can be carried out with low energy consumption, and is suited for mixing even with a disposable static mixer.The present invention provides a process for producing a mixture of a two-liquid mixing type curable resin by mixing the constituents of the resin, wherein mixing operations of the constituents are performed multiple times and a non-mixing time is provided between at least one of the mixing operations and another one of the mixing operations subsequent thereto.
US08425823B2 Apply piston seal for a clutch
A method of applying an apply piston seal is provided for a clutch assembly utilizing a balance piston. The method includes applying a rubber portion on an interior surface of an axially extending arm of the apply piston and applying a seal on an exterior surface of the axially extending arm of the apply piston.
US08425816B2 Shaping slurry and shaping method
A shaping slurry that forms a shaped product with a granule includes: a water-based solvent; a hydrophobic granule that forms the shaped product; and an amphiphatic solid polymer that forms the shaped product, and is dissolved in the water-based solvent.
US08425814B2 Method for preparing hydrophilic polyethersulfone membrane
The present disclosure relates to improved efficient and effective systems and methods of manufacturing hydrophilic polyethersulfone (PES) membrane suitable for commercial applications and the resultant hydrophilic polyethersulfone (PES) membrane suitable for commercial applications produced thereby and includes methods of manufacturing hydrophilic polyethersulfone (PES) membrane comprising the acts of: providing hydrophobic PES membrane; prewetting the hydrophobic PES membrane in a sufficient amount of a liquid having a sufficiently low surface tension; exposing the wet hydrophobic PES membrane to a sufficient amount of an aqueous solution of oxidizer; and after the exposing act, heating the hydrophobic PES membrane for a sufficient time at a sufficient temperature and methods of manufacturing hydrophilic polyethersulfone (PES) membrane comprising the acts of: providing gel PES membrane; exposing the gel PES membrane to a sufficient amount of an aqueous solution of oxidizer; and after the exposing act, heating the hydrophobic PES membrane for a sufficient time at a sufficient temperature and the resulting products.
US08425812B2 Dental blank and method of making a dental ceramic blank
A method of making a dental blank comprises the steps of independently compacting a first and second zone of a quantity of ceramic particles. During compacting, the first and second zones have different compaction factors in at least one stage. Such blanks may be pre-sintered and used in the manufacture of dental restorations. The method may help in controlling the homogeneity of the material structure during manufacturing the blanks.
US08425811B2 Method and system for generating sulfur seeds in a moving liquid
Sulfur seeds may be produced by spraying liquid molten sulfur from a sulfur spray nozzle into a moving stream of liquid. Some of the sulfur may pass through the liquid and some of the sulfur may be entrained in and transported by the stream of liquid, or all of the sulfur may be entrained in the stream of liquid. The sulfur droplets that are entrained in the stream of liquid may be carried by the liquid to a cooling tank, which may be a spiral dewaterer tank with an angled bottom and a screw conveyor. An opening may be made in the bottom surface of the screw conveyor housing of the spiral dewaterer tank for liquid to drain from the screw conveyor as it moves sulfur seeds from the tank to a the drum. A screen may be disposed across the opening, and a drain trough attached to the screw conveyor housing to capture any liquid and solids that move through the screen. A wash line may assist in moving solids that pass through the screen.
US08425807B2 Solar cell and composition used for manufacturing solar cell
A paste-like composition for a solar cell provided by the present invention contains a mixed aluminum powder prepared by mixing a small particle diameter aluminum powder, which has a D50 of particle size distribution based on laser diffraction of 3 μm or less and a ratio of D10 to D90 (D10/D90) of 0.2 or more, and a large particle diameter aluminum powder, which has a D50 that is 2 to 6 times the D50 of the small particle diameter aluminum powder and a ratio of D10/D90 of 0.2 or more.
US08425803B2 Nanocrystal doped matrixes
Matrixes doped with semiconductor nanocrystals are provided. In certain embodiments, the semiconductor nanocrystals have a size and composition such that they absorb or emit light at particular wavelengths. The nanocrystals can comprise ligands that allow for mixing with various matrix materials, including polymers, such that a minimal portion of light is scattered by the matrixes. The matrixes of the present invention can also be utilized in refractive index matching applications. In other embodiments, semiconductor nanocrystals are embedded within matrixes to form a nanocrystal density gradient, thereby creating an effective refractive index gradient. The matrixes of the present invention can also be used as filters and antireflective coatings on optical devices and as down-converting layers. Processes for producing matrixes comprising semiconductor nanocrystals are also provided. Nanostructures having high quantum efficiency, small size, and/or a narrow size distribution are also described, as are methods of producing indium phosphide nanostructures and core-shell nanostructures with Group II-VI shells.
US08425798B2 Liquid crystal polyester composition, reflective plate and light-emitting device
The present invention provides a composition comprising a liquid crystal polyester, a white pigment and a glass fiber bundle obtained by bundling glass fibers using a sizing agent comprising a polyurethane having a polyester polyol unit and at least one of an aliphatic diisocyanate unit or an alicyclic diisocyanate unit, wherein the polyester polyol unit is a polyol unit having an aliphatic polyhydric alcohol unit and at least one of an aliphatic polybasic acid unit or an alicyclic polybasic acid unit. The liquid crystal polyester composition can provide a reflective plate having a high reflectivity.
US08425796B2 Refrigerator oil
Provided is a refrigerating machine oil which contains a base oil mainly containing at least one substance selected from the group consisting of a mineral oil, a synthetic alicyclic hydrocarbon compound, and a synthetic aromatic hydrocarbon compound and having a kinematic viscosity at 40° C. of 1 to 8 mm2/s. The refrigerating machine oil is applied to refrigerators including a sliding part formed of an engineering plastic or including an organic coating film or an inorganic coating film. The refrigerating machine oil enables to improve energy-saving performance due to its low viscosity, has a low frictional coefficient and good sealing property, and is suitably used in various refrigeration applications, especially in closed-type refrigerators.
US08425795B2 Compositions comprising fluoroolefins and uses thereof
The present invention relates to fluoroolefin compositions. The fluoroolefin compositions of the present invention are useful as refrigerants or heat transfer fluids and in processes for producing cooling or heat. Additionally, the fluoroolefin compositions of the present invention may be used to replace currently used refrigerant or heat transfer fluid compositions that have higher global warming potential.
US08425794B2 Composition and method for producing an insulating product
A method for producing a finely subdivided insulating material includes the steps of: preparing a fluid composition by mixing together an alkaline silicate, a metal hydroxide and an impermeabilizing agent, heat-treating the composition so as to produce a plurality of small cavities in the composition, and finely subdividing the composition.
US08425793B2 Process and device for cleaning and etching a substrate with a transparent conductive oxide layer
A simple process is disclosed for treating substrates having pre-structured zinc oxide layers on rigid or flexible supports. The ZnO is treated with an etching medium then with a cleaning liquid. The treatment with the etching and cleaning liquids is carried out while the substrate is conveyed through a device. The process is technically simple to implement and makes it possible to regularly and homogeneously roughen and texturize ZnO layers of up to 1 m2. The device for treating substrates having pre-structured zinc oxide layers on rigid or flexible supports has for that purpose a first means for treating the substrate with an etching liquid, a second means for treating the substrate with a cleaning liquid, and another means, in particular transport rollers, for conveying the substrate from the first to the second means.
US08425792B2 Methods of patterning a conductor on a substrate
A method of patterning a conductor on a substrate includes providing an inked elastomeric stamp inked with self-assembled monolayer-forming molecules and having a relief pattern with raised features. Then the raised features of the inked stamp contact a metal-coated visible light transparent substrate. Then the metal is etched to form an electrically conductive micropattern corresponding to the raised features of the inked stamp on the visible light transparent substrate.
US08425791B2 In-chamber member temperature control method, in-chamber member, substrate mounting table and plasma processing apparatus including same
In a method of controlling the temperature of an in-chamber member used in a plasma processing apparatus that processes a target substrate with plasma, a plurality of power-feeding portions is provided in the in-chamber member and the in-chamber member is heated by supplying electric power thereto through the power-feeding portions. A resistance value or resistivity of the in-chamber member is measured and the electric power is controlled based on the temperature of the in-chamber member estimated from the resistance value or resistivity. The in-chamber member includes one or more annular members arranged around the target substrate. The in-chamber member is a member making contact with plasma within a chamber and existing near the target substrate.
US08425789B2 Method and apparatus for anisotropic etching
In anisotropic etching of the substrates, ultra-thin and conformable layers of materials can be used to passivate sidewalls of the etched features. Such a sidewall passivation layer may be a Self-assembled monolayer (SAM) material deposited in-situ etching process from a vapor phase. Alternatively, the sidewall passivation layer may be an inorganic-based material deposited using Atomic Layer Deposition (ALD) method. SAM or ALD s layer deposition can be carried out in a pulsing regime alternating with sputtering and/or etching processes using process gasses with or without plasma. Alternatively, SAM deposition is carried out continuously, while etch or sputtering turns on in a pulsing regime. Alternatively, SAM deposition and etch or sputtering may be carried out continuously. Both types of suggested passivation materials give advantage over state-of-the-art methods in ability to carefully control thickness and uniformity of the layers, thus enable anisotropic etching process for high aspect ratio nanosize features.
US08425783B2 System and method that removes contaminants from sulfur
A system and method for removing contaminant from sulfur (or sulphur) to a level that allows re-processed sulfur to reenter a supply chain. The system and method melt contaminated sulfur, filters the molten sulfur, and then dispenses the less contaminated sulfur after filtering it. More specifically, solid contaminated sulfur enters a settling tank, while heated molten sulfur circulates through the system and the settling tank. The circulation of the molten sulfur assists in the melting process of the solid sulfur, allowing the solid sulfur to melt efficiently. In preferred embodiments of the system, the system uses steam jacked sulfur lines and steam tracing to maintain temperatures for melting the solid sulfur and maintaining the molten state of the sulfur circulating through the system. Furthermore, the system comprises a programmable logic controller, which controls motors, pumps, valves, and environment monitoring instruments.
US08425773B2 End cap assembly adapted for interconnecting filtration elements
The disclosure describes end cap assemblies adapted for interconnecting filtration elements in end-to-end relationship and including means for selectively preventing relative rotation between adjacent end caps once engaged.
US08425772B2 Filtration device with releasable additive
A filtration device is provided that includes a filter component and an additive component. The filter component includes concentrically arranged filtering elements disposed in a filter-in-filter configuration. The additive component includes at least one additive material that is introduced into a working fluid to be filtered. The filter component and additive component provide an assembly for a filtration system that would filter a variety of working fluids. The filter component and additive component provides an assembly that can filter fluids more efficiently. As a result, fluids may enjoy, for example, extended drainage intervals and thereby reduce component wear.
US08425768B2 System and method for wastewater treatment
The present disclosure is directed towards systems and methods for the treatment of wastewater. A system in accordance with one particular embodiment may include an oxidation reactor configured to receive a flow of wastewater from a wastewater producing process. The oxidation reactor may be further configured to oxidize a chemical associated with the flow of wastewater with an oxidation agent. The oxidation reactor may include at least one reaction member configured to pressurize at least a portion of the oxidation reactor. The system may further include at least one resin tank configured to contain an ion exchange resin configured to target a particular metal, the at least one resin tank configured to receive an output from the oxidation reactor. Numerous other embodiments are also within the scope of the present disclosure.
US08425765B2 Method of injecting solid organic acids into crude oil
Solid organic acids may be introduced into hydrocarbon solvents to form dispersions; the dispersions in turn may be introduced into crude oil. A wash water may be added to the crude oil to create an emulsion. The organic acids may transfer metals and/or amines from a hydrocarbon phase into an aqueous phase in an electrostatic desalter which resolves the emulsion into the two phases. Suitable solid organic acids include, but are not necessarily limited to, C2-C4 alpha hydroxyacids, such as, but not necessarily limited to, glycolic acid, malic acid, maleic acid, malonic acid, succinic acid and even sulfamic acid, chloroacetic acid, thiomalic acid, including esters of, polymers of, amine salts of, alkali metal salts of, and/or ammonium salts of all of these acids.
US08425760B2 Process for converting gas into liquids with simplified logistics
The invention concerns a process for converting a stream of natural or associated gas into liquid fractions, comprising: a) a step for converting said stream of gas into a synthesis gas SG; b) a step FT for Fischer-Tropsch synthesis to convert the SG into liquid fractions; c) a step for fractionating the effluents from the Fischer-Tropsch synthesis into at least one relatively heavy fraction comprising waxes with a boiling point of 565° C. or more and at least one relatively light fraction; d) a step HCKI for isomerization hydrocracking of the relatively heavy fraction, in which at least 75% by weight of the fraction of the feed with a boiling point of more than 565° C. is converted into compounds boiling below 565° C.; e) at least one step for mixing at least the effluents from step HCKI (step d)), the light fraction from step c) and a crude oil P, to thereby produce an oil P*.
US08425758B2 Small volume in vitro analyte sensor and methods of making
A sensor utilizing a non-leachable or diffusible redox mediator is described. The sensor includes a sample chamber to hold a sample in electrolytic contact with a working electrode, and in at least some instances, the sensor also contains a non-leachable or a diffusible second electron transfer agent. The sensor and/or the methods used produce a sensor signal in response to the analyte that can be distinguished from a background signal caused by the mediator. The invention can be used to determine the concentration of a biomolecule, such as glucose or lactate, in a biological fluid, such as blood or serum, using techniques such as coulometry, amperometry, and potentiometry. An enzyme capable of catalyzing the electrooxidation or electroreduction of the biomolecule is typically provided as a second electron transfer agent.
US08425756B2 Apparatus and method for producing electrolyzed water
An apparatus for producing electrolyzed water includes an electrochemical cell and a solution reservoir containing a solution and having an outlet. An injection pump has an input end in fluid communication with the outlet of the solution reservoir and an output end in fluid communication with the electrochemical cell, wherein the injection pumps an amount of the solution from the solution reservoir to mix with a water solution and enter the electrochemical cell. A current feedback sensor senses a cell current in the electrochemical cell. A current control unit in data communication with the current feedback sensor and the injection pump wherein the current control unit compares the cell current with a preselected current and adjusts the amount of solution pumped from the injection pump responsive to the comparison. The apparatus may also include an automatic control feedback system to monitor and adjust pH.
US08425750B2 Fluid structure control device
A fluid structure control device has a liquid chamber holding a solution containing an electrolyte dissolved therein and conductive particles dispersed in the solution, and a pair of electrodes for applying an AC voltage to the conductive particles in the liquid chamber. Electro-osmotic flows are caused to occur due to electric double layers induced at the interface between the solution and the conductive particles by application of a voltage, thereby producing interaction among the conductive particles to displace the conductive particles and change reversibly the dispersion state of the conductive particles in accordance with the applied voltage.
US08425745B2 Electrochemical nanosensors for biomolecule detection
Sensor devices, methods and kits for detection of biomolecules are provided. According to various embodiments, the devices, methods and kits provide enhanced sensitivity through the measurement of electrochemical impedance and related properties. Certain embodiments employ nanostructured electrode elements including nanotubes, nanoparticles, nanowires, and nanocones. In a particular embodiment, single walled carbon nanotubes disposed in interconnected networks are used as electrodes. The device, methods and kits described herein have application for detection and measurement of biomolecular species including polynucleotides, proteins, polysaccharides and the like.
US08425734B2 Membrane-based hybrid process for separation of mixtures of organics, solids, and water
A system and process that are a hybrid of distillation and membrane separations offers a highly efficient means of separating a fluid feed mixture into organic, solid, and aqueous components. The distillation section is followed by two membrane separation sections operated in parallel, with the distillation section separating the feed mixture into an organics-rich fraction and an organics-depleted and solids-rich fraction. One membrane section operates on the organics-rich fraction and separates it into a more organics-rich sub-fraction and a water-rich, organics-depleted sub-fraction, while the other membrane section operates on the organics-depleted, solids-rich fraction from the distillation section and separates it into a solids-rich sub-fraction and a solids-depleted, water-rich sub-fraction.
US08425732B2 Method of operation for a recycler assembly
A method of operating an assembly for recycling a solvent from a contaminated solvent solution including a source for the contaminated solvent solution at a level and a recycling assembly including a reservoir module and a recycler module. The reservoir module includes a reservoir and the recycler module includes a controller and a distillation assembly including a distiller having a conduit and a pressure relief valve. The pressure relief valve includes a tube. The method includes connecting the conduit to the source below the level; connecting the pressure relief valve tube to the source; pumping solvent into the reservoir, distiller and conduit to an operational level; and selecting a duty cycle of the controller to regulate a rest period after the controller operation of a distillation cycle.
US08425730B2 Method and device for the production of tissue paper
The invention relates to a method for the production of a web of tissue paper, including the steps of: depositing a layer of an aqueous suspension of papermaking fibers on at least one forming fabric; reducing the water content of the layer until the weight percentage of fiber in the layer is brought up to a first value; wet-embossing the layer in a nip between a pair of embossing rollers; and drying the layer to form a web of tissue paper.
US08425728B2 Print media for high speed, digital inkjet printing
Disclosed is a print medium for high speed, digital inkjet printing, which has high brightness and is resistant to yellowing. The print medium includes a base paper formed from a fiber furnish containing at least 30% by weight of mechanical pulp, and a coating layer formed on at least one surface of the base paper. The coating layer contains a metallic salt, a combination of two different binders at a predetermined ratio, and at least one inorganic pigment. A method of making the print medium is also disclosed.
US08425726B2 Process for improving paper strength
The present invention provides a process for preparing a paper or paper board of improved strength which comprises the steps of i) providing a cellulosic thick stock, ii) diluting the thick stock of step i) to form a thin stock, iii) draining the thin stock of step ii) on a wire to form a web, and iv) drying the web of step iii) to form paper or paper board, wherein the cellulosic thick stock of step (i) comprises organic polymeric microparticles, as well as paper obtainable by above process.
US08425724B2 Anionic functional promoter and charge control agent with improved wet to dry tensile strength ratio
The invention relates to a composition comprising (a) a functional promoter comprising a water-soluble anionic polymer having a molecular weight of at least about 50,000 daltons and a molecular weight charge index value of at least about 10,000; (b) a cationic surfactant component; such that when the composition treats a fibrous substrate, in conjunction with a cationic strength agent, the treated fibrous substrate exhibits (i) a ratio of wet tensile strength to dry tensile strength ranging from about 1:5 to about 1:2 and (ii) an increase in a ratio of wet tensile strength to dry tensile strength of at least about 10%, as compared to when the fibrous substrate is treated with the functional promoter and without a surfactant. The invention also relates to a paper product made with such a system, and method for imparting wet strength to a paper product with the functional promoter.
US08425721B2 Method and apparatus for treating a fibrous web
Treatment liquid is sprayed onto a fibrous web surface by one or more spray boxes (21, 11, 23) having a spray chamber (4) and spray nozzles (1) in the travel direction of the fibrous web before a nip (N1 . . . N7; N8; N9) formed between them by two nip means (11 . . . 18) provided with a movable surface, and air and/or treatment medium mist is removed from the spray chamber and after having added treatment liquid the fibrous web is pressed in this nip. The spray chamber (4) is formed between a first spray box (21, 11, 23; 24; 25) and any successive first nip means (13; 52, 53; 62, 63) and second nip means (13; 52, 53; 62, 63), the fibrous web is guided supported by the surface of the first nip means to the spray chamber and the fibrous web is supported thereon during the spraying of treatment liquid.
US08425717B2 Phosphate bonded composites and methods
Inorganic-organic composite articles and methods for producing them using inorganic acidic/alkaline precursor components as inorganic adhesives is provided. Articles prepared therefrom provide improved flexibility, zero flame spread, no release of volatile organic compounds, and low carbon foot print.
US08425711B2 Glass substrate with protective glass, and process for producing display device using glass substrate with protective glass
To provide a glass substrate with protective glass which suppresses formation of microscopic scratches on the back surface of the glass substrate in the production process for a display device, and which prevents a strength decrease in the process or formation of etch pits after a chemical etching treatment; a process for producing a display device by using the glass substrate with protective glass; and a double-sided removable resin sheet for the glass substrate with protective glass.A glass substrate with protective glass, which comprises a glass substrate and a protective glass plate laminated on each other, and which is characterized in that the glass substrate and the protective glass plate are laminated by a double-sided removal resin sheet.
US08425710B2 Automated placement of vibration damping materials
Damping material is installed on a structure by moving a material placement head over the structure, and using the head to place the material on the structure.
US08425708B2 Continuous fabrication of parts using in-feed spools of fiber reinforced thermoplastic
Thermoplastic composite laminate parts with tailored and varying thickness and/or curved sections are manufactured in a continuous process. Automated equipment or hand lay-up is used to collate parts or components into a multi-layer stack. Each stack contains all plies, including ply build-up areas, tacked in the proper location to maintain orientation and location. Some or all of the plies may be continuously fed from spools of single or multiply ply material. Ply consolidation tooling contains all necessary part features and is coordinated to the customized multiple ply stacks to form a single integrated thermoplastic composite laminate potentially having areas of differing thickness from the multiple ply stacks.
US08425705B2 Method of manufacturing a blank made from thermoplastic composite material, associated manufacturing tool and use of the method to produce structural aircraft parts
A method of manufacturing a blank made from thermoplastic composite material, in which a pressure and temperature cycle is applied by pressing on top of a compacting plate that is itself on top of a stack of fibers including continuous fibers pre-impregnated with a thermoplastic resin, which stack has been previously placed on a board with the film enveloping the stack being brought into contact with fixing blocks arranged at the periphery of the board, and by heating the stack so as to reach at least the melting temperature of the resin while leaving the film infusible and smooth, and allowing the gas(es) present in the stack to escape through at least one opening left in the enveloping film and then through at least one emerging channel formed in the compacting plate and/or in the board and/or in the fixing blocks.
US08425704B2 Silicon-based explosive devices and methods of manufacture
Silicon-based explosive devices and methods of manufacture are provided. In this regard, a representative method involves: providing a doped silicon substrate; depositing undoped silicon on a first side of the substrate; and infusing an oxidizer into an area bounded at least in part by the undoped silicon; wherein the undoped silicon limits an exothermic reaction of the doped silicon to the bounded area. Another representative method involves: providing a doped silicon substrate; depositing a masking layer of low-pressure chemical vapor deposited (LPCVD) Silicon nitride to the first side of the substrate; patterning the nitride mask and etching the porous silicon, and infusing oxidizer into an area bounded by the LPCVD nitride; wherein the silicon nitride limits an exothermic reaction of the doped silicon to the bounded area.
US08425702B2 Precursor of an explosive composition including at least one ionic liquid and a method of desensitizing an explosive composition
An ionic liquid is disclosed. A precursor composition that comprises at least one ionic liquid and at least one energetic material is also disclosed, as is a method of synthesizing an ionic liquid and a method of desensitizing an explosive composition.
US08425698B2 Aluminum alloy sheet and method for manufacturing the same
An aluminum alloy sheet having excellent press formability and stress corrosion cracking resistance, comprises 3.3 to 3.6 percent by weight of Mg and 0.1 to 0.2 percent by weight of Mn, furthermore, 0.05 to 0.3 percent by weight of Fe and 0.05 to 0.15 percent by weight of Si, and the remainder comprises Al and incidental impurities, wherein the sizes of intermetallic compounds is 5 μm or less, the recrystallized grain size is 15 μm or less in the region at a depth of 10 to 30 μm below the sheet surface, and the surface roughness is Ra 0.2 to 0.7 μm.
US08425696B2 Sputtering target
Provided is a tantalum or a tantalum alloy target capable of shortening the burn-in time and minimizing the fluctuation in the deposition speed throughout the target life, whereby the production efficiency of semiconductors in the sputtering process can be improved and stabilized, and the production cost can be significantly reduced. With tantalum or tantalum-based alloy sputtering target, provided is a sputtering target, wherein FWHM (full width of half maximum) of a {200} crystal plane measured by X-ray diffraction of the sputtered outermost surface is 0.1 to 0.6°, and wherein the variation of FWHM is within ±0.05°.
US08425691B2 Stainless steel carburization process
The present invention is directed to a process for tempering steel comprising carburizing said steel in a vacuum furnace in the presence of a hydrocarbon carburizing gas in combination with hydrogen wherein said carburizing gas/hydrogen combination is administered to the vacuum furnace by cyclically reducing the pressure in the furnace followed by the pulsed addition of the hydrocarbon carburizing gas consisting of an acetylene/hydrogen mixture is in a ratio of from about 1:1 to about 1:10 to replenish the air removed in the pressure reduction step.
US08425686B2 Liquid processing apparatus, liquid processing method, and recording medium having program stored therein
A liquid processing apparatus is provided which can reduce the amount of liquids used and reduce the difference of the process level between objects to-be-processed. The liquid processing apparatus includes a main pipe, a liquid supply device, a main valve, a plurality of branch pipes, and a plurality of processing units. The liquid supply device includes a mixer, a first liquid supply pipe, and a second liquid source supplying a second liquid and supplies a mixed liquid prepared by mixing the first and second liquids in the mixer to one end of the main pipe. The main valve is configured to close the other end of the main pipe opposite to the liquid supply device when the object to-be-processed is processed in the processing unit.
US08425682B2 High strip rate downstream chamber
A gas chamber contains upper and lower chamber bodies forming a cavity, a heating chuck for a wafer, a remote gas source, and an exhaust unit. Gas is injected into the cavity through channels in an injector. Each channel has sections that are bent with respect to each other at a sufficient angle to substantially eliminate entering light rays entering the channel from exiting the channel without reflection. The channels have funnel-shaped nozzles at end points proximate to the chuck. The injector also has thermal expansion relief slots and small gaps between the injector and mating surfaces of the chamber and gas source. The temperature of the injector is controlled by a cooling liquid in cooling channels and electrical heaters in receptacles of the injector. The upper chamber body is funnel-shaped and curves downward at an end of the upper chamber body proximate to the chuck.
US08425681B1 Low-dislocation-density epitatial layers grown by defect filtering by self-assembled layers of spheres
A method for growing low-dislocation-density material atop a layer of the material with an initially higher dislocation density using a monolayer of spheroidal particles to bend and redirect or directly block vertically propagating threading dislocations, thereby enabling growth and coalescence to form a very-low-dislocation-density surface of the material, and the structures made by this method.
US08425679B2 Calcium ferroaluminate compound, cement admixture and its manufacturing methods, and cement composition
It is the object of the invention to provide a cement admixture, and a cement composition that can impart good enough rustproofness to reinforcing bars in hardened cement concrete, and can have resistance to penetration of chloride ions entering from the outside, prevent the hardened cement concrete from getting porous due to reduced leaching of Ca ions and have a self-recovery capability.The invention provides a cement admixture characterized by containing a calcium ferroaluminate compound comprising a CaO—Al2O3—Fe2O3 system, and having a Fe2O3 content of 0.5 to 15% by mass and a CaO.2Al2O3 structure with a CaO/Al2O3 molar ratio ranging from 0.15 to 0.7. It is preferable that the fineness is 2,000 to 7,000 cm2/g as represented in terms of the Blaine's specific surface area value; the potentially hydraulic substance and/or pozzolan substance (pozzolan substance or the like) is also used; the pozzolan substance or the like contains one or two or more selected from the group consisting of finely pulverized, quenched, granulated blast-furnace slag, fly ash, silica fume, metakaolin, incinerated pulp sludge ash, incinerated sewage sludge ash, and waste glass powder; and the blending proportion of the calcium ferroaluminate compound to the pozzolan substance or the like ranges from 10/1 to 1/10 by mass. The invention also provides a cement composition containing cement and the cement admixture.
US08425678B2 Low odor asphalt compositions and low odor asphalt produced therefrom
A composition for reducing undesirable odors emitted by hydrocarbonaceous materials is provided. The composition contains at least one aldehyde-containing compound and, optionally, one or more ketone-containing compound and/or a carrier. The composition is free of ester-containing compounds. In at least one exemplary embodiment, the composition contains one or more aldehyde-containing compounds and a liquid carrier. The aldehyde-containing compound(s) has a molecular weight greater than 100 daltons and may be chosen from vanillin or cinnamaldehyde. The ketone-containing compound(s) has a molecular weight greater than 100 daltons, and in exemplary embodiments, from about 120 to about 1,000 daltons. Undesirable odors from hot asphalt are reduced by the composition without adversely affecting the physical and performance properties of the asphalt or decreasing the flash point of the asphalt. The composition may be added to asphalt in a molten or semi-molten form to reduce or eliminate unpleasant odors and form a low odor asphalt.
US08425675B2 Recrystallization type of ink composition
A recrystallization type of ink composition comprises a solvent, a crystalline material, and a colorant. When the recrystallization type of ink composition is applied to a non-absorption surface such as a whiteboard, a glass surface, and a plastic surface, it is recrystallized to provide a visual effect of a metal sense at the applied part.
US08425674B2 System using unutilized heat for cooling and/or power generation
A sorption system is disclosed that includes a sorbent material and a fluid, in which the sorbent material and fluid in combination have a pressure index of at least 1.2.
US08425673B2 Regenerative dryers with a bypass
Regenerative air dryers are disclosed for feeding pressurized air with a controlled moisture content to a header. In one embodiment, a dryer comprises first and second chambers alternating between drying and regenerating phases. One of the chambers is at the drying phase while the other is at the regenerating phase. A controller is programmed to switch the phase of the chambers between drying and regenerating when the desiccant in the chamber at the drying phase has retained water to a predetermined capacity. A bypass line bypasses both chambers. An input provides air to the chamber at the drying phase and to the bypass line. A dew point feedback system controls a volume of air passing through the bypass line. Means are included for combining air from the bypass line with air exiting the chamber at the drying phase to provide air with a controlled dew point to the header.
US08425670B2 Plant for separating oil from a gas mixture, and a method for separating oil from a gas mixture
The invention refers to a plant and a method for separating oil in form of particles and/or mist from a fossil gas mixture for obtaining a separated gas. The plant comprises a centrifugal separator with a stationary casing defining a separation space. The casing permits a pressure of at least 10 bars in the separation space. The centrifugal separator comprises an inlet for the gas mixture, a gas outlet for the separated gas and an oil outlet for discharging separated oil. A separating member for separating the gas mixture comprises a plurality of separating discs and is provided in the separation space. A drive motor is connected to the separating member via a spindle and rotate the separating member about an axis (x) of rotation.
US08425664B2 Mutual remediation of effluents of petroleum production
Petroleous production is associated with effluents well known to foul lines, nozzles, and containers while consuming substantial energy to assist in both production and remediation. A heat exchanger and manifold system maximizes flows, minimizes changes in flow cross-section, and maximizes heat transfer area, while recycling both water and heat between processes. Dirty regions and clean regions result from scrubbing horizontal exhaust stacks and evaporation of production water in concert to remediate one another, while recycling a significant portion of the energy consumed by each. The heat exchanger relies on a manifold having many layered conduits, each connected to a single layer level of one or more cylindrical conduits in the exchanger. The cylinders of the exchanger themselves are arranged in multiple layers, each layer of a heat exchanger element being connected to a single layer of the manifold. Any shape of cylinder may work, but a right circular cylinder having corrugated sheets spacing the layers may be simple to construct.
US08425654B2 Purification process for 153Gd produced in natural europium targets
An alteration of the traditional zinc/zinc-amalgam reduction procedure which eliminates both the hazardous mercury and dangerous hydrogen gas generation. In order to avoid the presence of water and hydrated protons in the working solution, which can oxidize Eu2+ and cause hydrogen gas production, a process utilizing methanol as the process solvent is described. While methanol presents some flammability hazard in a radiological hot cell, it can be better managed and is less of a flammability hazard than hydrogen gas generation.
US08425653B2 Plasmon mediated photoinduced synthesis of silver triangular bipyramids
A method of preparing silver triangular bipyramids having a high shape selectivity and low edge length variation is disclosed. Also disclosed are silver triangular bipyramids prepared by this method.
US08425643B2 Vent head
A vent head for a steam system is provided. In one embodiment, the vent head may comprise a body defining a vent head chamber and having a vent head outlet. The vent head comprises a steam inlet conduit having a steam outlet that opens into the vent head chamber and a baffle disposed within the vent head chamber and above the steam outlet. The baffle may have an impingement region and a convex portion which is disposed between the impingement region and the edge of the baffle. In use, the steam outlet discharges steam into the vent head chamber which impinges on the impingement region of the baffle, thereby separating entrained liquid water from the steam.
US08425642B2 Cyclonic separating apparatus
The present invention relates to a cyclonic separating apparatus and a vortex finder plate for use in a cyclonic separating apparatus, the vortex finder plate including a support structure and a plurality of vortex finder support flaps extending from the support structure, each vortex finder support flap comprising a vortex finder. At least one of the vortex finder support flaps is connected to the support structure by a hinge.
US08425641B2 Inlet air filtration system
Embodiments of the present invention provide an inertial filtration system for air-ingesting machines. The inertial filter 100 may comprise a reducer 133 downstream of a vortex generator. The reducer 133 decreases the area that the airstream flows through, which may increase the angular momentum and the centrifugal forces acting on the particles of the ingested airstream. This may increase the cleaning performance and a decrease in the pressure drop across the inertial filter 100. Generally, the inertial filter functions such that flow components of higher density are separated from the rest of the airstream. The higher density flow components are bled out of the inertial filter 100 via an outlet 135. The remaining flow components flow downstream to compressor section 535.
US08425637B2 Process and system for converting waste material to fuel or synthetic gas feedstock
A waste processing system and method is described. The waste processing system may be used to treat any type of waste material that may be decomposed upon the application of energy, wherein recyclable metal and/or a gaseous end product is/are generated which may have commercial or industrial applications. The waste material may be reduced in size and passed to a purge vessel where the oxygen content of the waste material is reduced. The waste material is then heated in a heat exchanger which may be linearly elongated and passed to a conversion chamber where it is treated with H—H—O gas torches. A final gaseous end product is generated which may be used as a fuel source.
US08425634B2 Fire log
A fire log includes a single fire log cut in a specific design to enable easy ignition and sustenance of a self-contained campfire. The single log is designed to stand vertically and may range from twenty-four to seventy-two inches in height depending on diameter. In most instances, four vertical, diametrical cuts are made in the log forming eight pie-slice segments. The cuts extend from the top surface of the log downward toward the base of the log. The vertical cuts stop short of the entire length of the log leaving approximately 25% of the length uncut. The uncut portion forms the base of the log. One of the segments is cut horizontally at its lower end adjacent the top of the base so that the segment can be removed from the log for air flow control.
US08425633B2 Methods for integrated fast pyrolysis processing of biomass
Methods, process, apparatus, equipment, and systems are disclosed for converting biomass into bio-oil fractions for chemicals, materials, feedstocks and fuels using a low-cost, integrated fast pyrolysis system. The system improves upon prior art by creating stable, bio-oil fractions which have unique properties that make them individually superior to conventional bio-oil. The invention enables water and low-molecular weight compounds to be separated into a final value-added fraction suitable for upgrading or extracting into value-added chemicals, fuels and water. Initial bio-oil fractions from the process are chemically distinct, have low-water content and acidity which reduces processing costs normally associated with conventional bio-oil post-production upgrading since fewer separation steps, milder processing conditions and lower auxiliary inputs are required. Biochar is stabilized so that it can be handled safely. The integrated fast pyrolysis process includes biomass storage, preparation, pretreatment, and conversion, product recovery and processing to create and store stable biochar and bio-oil fractions.
US08425631B2 Fuel usable to control the emissions and/or opacity of gas released into the atmosphere
A fossil-fuel-fired system, which includes an emissions-control-agent dispenser, a furnace, an emissions monitor and, optionally, a controller, is disclosed. The emissions-control-agent dispenser provides a prescribed amount of organic-emissions-control agent, such as, for example, an opacity-control agent to the fossil-fuel-fired system. The furnace includes an exhaust communicating with the atmosphere. The emissions monitor is capable of measuring at least one property of the flue-gas communicated through the exhaust to the atmosphere. For example, when an organic-emissions-control agent is an opacity-control agent, the emissions monitor has the capability of at least measuring opacity. When included, the controller communicates with at least the emissions-control-agent dispenser and the emissions monitor.
US08425629B2 Alkylated hydroxyaromatic compound from conventional and high vinylidene polyisobutylenes and compositions and processes thereof
An additive composition comprises a Mannich reaction product of a) a polyisobutylene (PIB) alkylated hydroxyaromatic compound, b) an aldehyde, and c) an amine containing at least one reactive amino group where the PIB is derived from a conventional PIB and a high vinylidene PIB. A fuel additive concentrate composition, a fuel composition, and a method to reduce deposit formation in a fuel system of an internal combustion engine employ the additive composition that comprises the Mannich reaction product which is unexpectedly effective in reducing deposits. A PIB alkylated hydroxyaromatic compound, that is prepared from a mixture of high vinylidene and conventional PIBs, is both a functional additive and an intermediate to a functional additive and the process to prepare it involves running the alkylation reaction at 5 to 40° C.
US08425617B2 Knee prostheses with convex slope on portion of tibial articular surface
Knee prostheses featuring components that more faithfully replicate the structure and function of the human knee joint in order to provide, among other benefits: greater flexion of the knee in a more natural way by promoting or at least accommodating internal tibial rotation in a controlled way, replication of the natural screw home mechanism, and controlled articulation of the tibia and femur respective to each other in a more natural way. In a preferred embodiment, such prostheses include an insert component disposed between a femoral component and a tibial component, the insert component preferably featuring among other things a reversely contoured posterolateral bearing surface that helps impart internal rotation to the tibia as the knee flexes. Other surfaces can also be specially shaped to achieve similar results, preferably using iterative automated techniques that allow testing and iterative design taking into account a manageable set of major forces acting on the knee during normal functioning, together with information that is known about natural knee joint kinetics and kinematics.
US08425613B2 Expandable intervertebral implant
An intervertebral implant assembly includes first and second support members and a retention member. The first and second support members are configured to engage first and second vertebral bodies, respectively. The first and second support members define first and second guide portions, respectively. In particular, the first and second support members are slidably movable relative to each other. The retention member includes a face plate and an arm member extending from the face plate. The arm member is disposed between the first and second support members to maintain a relative position of the first and second support members. The face plate defines an access through hole in communication with the first and second guide portions.
US08425612B2 Minimally invasive interbody device assembly
A minimally invasive interbody device assembly that includes an interbody device that restores the disc space height between two vertebrae and an instrument detachably coupled to the interbody device for positioning the device in the disc space and delivering bone material to the disc space that is distributed on both sides of the interbody device. The device is inserted into the disc space using the instrument in a direction so that the wide dimension of the device is substantially parallel to the body of the vertebrae. The device is then rotated by the instrument so that the wide dimension of the device becomes perpendicular to the vertebral body so as to cause the disc space height to be restored. Bone graft material is then forced down the instrument so that the bone graft material is distributed on both sides of the device. The instrument is then detached from the device.
US08425609B2 Artificial intervertebral disc having a bored semispherical bearing with a compression locking post and retaining caps
An artificial intervertebral disc having a pair of opposing baseplates, for seating against opposing vertebral bone surfaces, uses a semispherical, bored bearing that is secured to the baseplates with compression locking posts and one or more retaining caps. The compression locking posts extend through the bearing bore and baseplate apertures such that the bearing is between the baseplates' inwardly facing surfaces. Retaining caps are attached to the compression locking posts, securing the baseplates to the bearing. Bearing surfaces on the inwardly facing side of each baseplate allow each baseplate to rotate relative to the bearing, however, rotation of each baseplate is limited by the interference of each baseplate and its respective retaining cap. Rotation of the baseplates about the longitudinal axis of the spine can be limited via a notch in the retaining caps and a groove in the baseplates, or vice versa.
US08425607B2 Anchor member locking features
An implantable medical device may include an implant member having an aperture extending therethrough. An anchor member may be configured to extend through the aperture. A locking ring may be supplied to inhibit back-out of the anchor member.
US08425606B2 Method and implant device for grafting adjacent vertebral bodies
A methodology for grafting together adjacent bony structures is provided using an implant device having an endplate with an inner disc portion and outer ring portion spaced from the inner disc portion by a connecting wall disposed therebetween. An endplate interior surface includes a retaining structure for securing the endplate to one of the bony structures, and endplate an exterior surface has an integrally formed socket. A ball-joint rod has a longitudinally extending body and an end, and at least a portion of the ball-joint rod end is curvilinear in shape. The curvilinear ball-joint rod end is rotatably disposed in the endplate socket to fixedly interconnect the bony structures.
US08425602B2 Curvilinear spinal access method and device
A curvilinear spinal access device having an expandable working portal. The device includes a slide having a channel with an open top and a movable top sized to cover the open top of the channel forming an expandable working portal with a proximal end and a distal end. The movable top can be moved between a closed position and an open position, wherein in the closed position the movable top blocks direct visualization between the proximal end and the distal end of the expandable working portal and in the open position movement of the movable top results in direct visualization from the proximal end to the distal end of the expandable working portal.
US08425601B2 Spinal stabilization devices and methods of use
The present application is directed to methods and devices that provide for asymmetrical movement of vertebral members. In one embodiment, first and second anchors connect the rod to the vertebral members. The rod may be fixedly connected to the first anchor, and movably connected to the second anchor. A limiting device may be positioned on one or both sides of the second anchor. The limiting device or devices control an extent of movement between the rod and the second anchor during vertebral motion. In one embodiment, the device controls an amount of flexion and extension of the vertebral members.
US08425599B2 Accommodating intraocular lenses and methods of use
Fluid-driven accommodating intraocular lenses comprising deformable optic portions.
US08425598B2 Implantable system for restoring accommodation capacity using internal energy
An implantable system for restoring accommodation capacity includes at least one ring configured to be implanted in a ciliary sulcus and a capacitor with a first capacitor plate and a second capacitor plate. The first capacitor plate is arranged on an implantable ring and the second capacitor plate is connected to a capsular bag.
US08425597B2 Accommodating intraocular lenses
Intraocular lenses for providing accommodation include an anterior optic, a posterior optic, and a lens structure. In one such lens, the lens structure comprises an anterior element coupled to the anterior optic and a posterior element coupled to the posterior optic. The anterior and posterior elements are coupled to one another at a peripheral region of the intraocular lens. The intraocular lens may also includes a projection extending anteriorly from the posterior element that limits posterior motion of the anterior optic so as to maintain a minimum separation between anterior optic and an anterior surface of the posterior optic.
US08425593B2 Collapsible prosthetic heart valves
Prosthetic heart valves, which are collapsible to a relatively small circumferential size for less invasive delivery into a patient and which then re-expand to operating size at an implant site in the patient, include a collapsible/expandable stent-like supporting structure and various components of flexible, sheet-like material that are attached to the supporting structure. For example, these sheet-like other components may include prosthetic valve leaflets, layers of buffering material, cuff material, etc. Improved structures and techniques are provided for securing such other components to the stent-like supporting structure of the valve.
US08425588B2 Avoiding stress-induced martensitic transformation in nickel titanium alloys used in medical devices
A process for assembling a medical device made from a nickel-titanium alloy for use in a mammalian body while avoiding the formation of stress-induced martensite and a medical device used in combination with a delivery system for deployment into the mammalian body are disclosed. By heating the nickel-titanium alloy of the medical device to a temperature above Md, and deforming and installing the device into a delivery system or holding capsule, it is possible to avoid the formation of stress-induced martensite in the stent, which stays in the austenitic phase throughout.
US08425581B2 Inhibition of platelet activation, aggregation and/or adhesion by hypothermia
A method for treating acute coronary syndromes (i.e., unstable angina or non-Q-wave MI) or transient ischemic attacks in a human or animal patient by placing a heat exchange apparatus in the patient=s vasculature and using that heat exchange apparatus to cool the patient to a temperature (e.g. 30-36_C) at which platelet inhibition (i.e., inhibition of platelet activation and/or aggregation and/or adhesion) occurs. Anti-shivering drugs or anesthesia may be administered to patients whose body temperature is cooled below that patient=s shivering threshold (typically approximately 35.5 C). If it is determined that platelet inhibition is no longer desirable, such as when the patient is about to undergo a surgical or interventional procedure wherein bleeding could be problematic, the hypothermia-induced platelet inhibition may be rapidly reversed by using the intravascular heat exchange apparatus to re-warm the patient=s body to normothermia or near normothermia.
US08425579B1 Therapeutic knee brace for a contrast therapy system
The present invention relates to a therapeutic knee brace system including a leg brace for support, a retainer for securing the therapeutic knee brace system to a knee joint therapy site, a brace joint providing a limited range of flexion to the knee brace, and an active thermal exchange bladder coupled to a contrast therapy system for delivering a therapy fluid at a select temperature, pressure and rate. Thermal exchange bladder is removable, and the pressure may be constant or dynamic. The angle of flexion may be selected by the therapy recipient, and the range of flexion of the brace joint is configurable. The knee brace may communicate range and instant angle of flexion of the brace joint to a continuous passive motion (CPM) device, and communication may be mechanical, electronic or wireless. A knee brace coupler attaches to a CPM coupler on the CPM device to selectively couple the therapeutic knee brace system to the CPM device.
US08425575B2 Bone plate supported by a leg member and used as a lever
System, including apparatus and methods, for fixing bone with a bone plate supported temporarily at a slant on bone by a leg member before the bone plate is used as a lever to reposition a region of the bone. In some embodiments, the leg member may be a post member that attaches to the bone plate by threaded engagement with an aperture of the bone plate. In some embodiments, the bone plate and the leg member may be used near the end of a long bone, such as on a distal portion of a radial bone.
US08425573B2 Method and system for attaching a plate to a bone
A guide tool having a through bore and at least one distal locating feature is provided. The distal locating feature of the guide tool is placed into a predetermined relationship with the plate. A fastener is engaged with a distal end of a driver shaft of a fastener driver. The fastener driver has a driver orientation means associated with the driver shaft. The fastener is inserted into the through bore of the guide tool with the fastener driver. The driver orientation means is mated with a guide orientation means located in the through bore of the guide tool. At least a portion of the fastener is inserted through the fastener hole. The fastener is secured into the bone through actuation of the fastener driver. The fastener driver is withdrawn from the guide tool, which is withdrawn from the plate.
US08425571B2 Method for stabilizing a motion segment of the spine of a patient
A dynamic stabilization device includes end caps that define a bore for receiving a corresponding bone screw therethrough. A spacer is engaged between each end cap and a cable passes through each of the components and is placed in tension to couple the spacer between the two end caps. The spacer is formed of a material that allows some flexible movement after implantation. An alternative stabilization device includes a spacer over-molded about two bushings defining the bores. According to a method of use, a stabilization device is passed along guide wires through a small incision. Once the device is in contact with the vertebrae, the bone screws are advanced along the guide wires and driven into the bone. One fastener bore may include a camming surface that causes distraction of the vertebrae as the bone screw is threaded into the vertebral bone.
US08425570B2 Apparatus, systems, and methods for achieving anterior lumbar interbody fusion
Assemblies of one or more implant structures make possible the achievement of diverse interventions involving the fusion and/or stabilization of lumbar and sacral vertebra in a non-invasive manner, with minimal incision, and without the necessitating the removing the intervertebral disc. The representative lumbar spine interventions, which can be performed on adults or children, include, but are not limited to, lumbar interbody fusion; translaminar lumbar fusion; lumbar facet fusion; trans-iliac lumbar fusion; and the stabilization of a spondylolisthesis.
US08425565B2 Modular percutaneous spinal fusion
A posterior spinal fusion system may include pedicle screws and one or more segments designed to be attached to the implanted pedicle screws via nuts to fuse spinal motion segments in a modular fashion. The pedicle screws may have semispherical receiving surfaces, and each segment may have mounting portions at both ends, with corresponding semispherical engagement surfaces. The nuts may also have semispherical surfaces. The semispherical surfaces permit polyaxial adjustment of the relative orientations of the segments and pedicle screws. Each mounting portion may have a passageway therethrough to receive the proximal end of the corresponding pedicle screw; each passageway may intersect the edge of the corresponding engagement surface to facilitate percutaneous placement. Such placement may be carried out through cannulae to provide a minimally invasive (MIS) implantation procedure.
US08425557B2 Crossbar spinal prosthesis having a modular design and related implantation methods
Modular spinal prosthesis having one of both of adaptable and configurable components are provided. The modular spinal prosthesis described herein provide an artificial articular configuration to replace damaged, worn or otherwise removed spinal facet elements.
US08425554B2 Suture passing K-wire
A method and apparatus for bunion repair using a suture passing K-wire configured to easily pass through bone tunnels with suture trailing. The suture passing K-wire includes a tapered guide pin with a multi-diameter shaft (i.e., comprising at least two regions or sections that have different diameters) and a loop which is securely attached to an end of the guide pin (i.e., to the smaller diameter section of the guide pin). The reconstruction system may be formed of a pair of buttons connected by a flexible strand. The procedure offers indirect placement of buttons and a minimally invasive approach.
US08425548B2 Occluding member expansion and then stent expansion for aneurysm treatment
This invention is a device and method to occlude an aneurysm comprising: a laterally-expanding occluding member (such as a relatively-flat balloon, mesh, net, or patch) that is positioned within the parent vessel of the aneurysm and then expanded laterally; and a radially-expanding structural member (such as a stent) that is positioned within the parent vessel of the aneurysm and then expanded radially after, or concurrently with, expansion of the laterally-expanding occluding member. Expansion of the radially-expanding member presses and holds the laterally-expanding occluding member into contact with the aneurysm neck, so that the laterally-expanding occluding member at least partially covers the aneurysm neck and reduces blood flow to the aneurysm. This invention has several potential advantages over devices and methods in the prior art, especially for treatment of wide-neck and fusiform aneurysms.
US08425547B2 Disposable skin pricker
A lancet body for a skin pricker has resiliently flexible fingers (9) with outwardly splayed tips (10). The device is fired by pressing a trigger (13) and a spring (5) urges the lancet forwards and the fingers (9) flex inwards as the tips (10) snap past barbs (11), so that the tips (10) of the arms (9) engage behind the barbs (11). If the user tries to push the lancet back into the cocked condition, the fingers (9) are trapped and will flex as the tips (10) press against the barbs (11) until the arms buckle and the tips (10) are pushed out through openings (14). Thus the lancet is arrested and immobilized before a re-cocked position is reached, and re-firing is prevented.
US08425545B2 Cordless hand-held ultrasonic cautery cutting device and method
A disposable ultrasonic surgical handle connectable to an ultrasonic transducer, an ultrasonic waveguide, a battery, and an ultrasonic-signal-generator assembly, includes a handle body having a power supply portion defining a battery-holding compartment, the battery-holding compartment having at least two battery contacts, a waveguide attachment dock exposed to the environment and shaped to accept the waveguide therein, an ultrasonic-signal-generator assembly dock exposed to the environment and shaped to selectively removably secure the ultrasonic-signal-generator assembly to the handle body and electrically couple the ultrasonic-signal-generator assembly to the battery contacts, and a transducer attachment dock exposed to the environment and shaped to substantially simultaneously place the ultrasonic transducer in coaxial alignment with the waveguide when the waveguide is disposed within the waveguide attachment dock and electrically couple the ultrasonic transducer to the ultrasonic-signal-generator assembly when the ultrasonic-signal-generator assembly is secured to the ultrasonic-signal-generator assembly dock. The battery can be removable.
US08425542B2 Aneurysm occlusion device containing bioactive and biocompatible copolymer shell and biocompatible metallic frame member
An endovascular device for occluding a vascular aneurysm is disclosed. The device includes a polymeric shell member that, in one embodiment, may be constructed from a bioactive and biocompatible polyurethane-diol-glycosaminoglycan copolymer, and a biocompatible metallic frame member. The copolymer is sufficiently flexible and strong for endovascular delivery into a vascular aneurysm and for use as a polymeric shell for receiving the biocompatible metallic frame member. The biometallic frame member may include one or more components constructed from a NiTi alloy.
US08425539B2 Luminal structure anchoring devices and methods
A device is provided for endoscopy or endosonography- guided transluminal interventions whereby two luminal structures in the body may be drawn toward each other and a fluid conduit formed in between. The device may have a penetrating member and a hollow central member to which is coupled a distal retention member and in one embodiment a proximal retention member. The retention members may each be positioned inside one of the luminal structures and expanded from a first condition to an expanded second condition having an increased radius. The length of the central member may be shortened and its diameter expanded to approximate the two retention members and thereby the luminal structures.
US08425534B2 Cam lock burr hole plug for securing stimulation lead
A burr hole plug comprises a plug base configured for being mounted around a cranial burr hole. The plug base includes an aperture through which an elongated medical device exiting the burr hole may pass. The burr hole plug further comprises a retainer configured for being mounted within the aperture of the plug base. The retainer includes a retainer support, a slot formed in the retainer support for receiving the medical device, and a clamping mechanism having a movable clamping element and a cam configured for being rotated relative to the retainer support to linearly translate the movable clamping element into the slot, thereby securing the medical device. The retainer further comprises another clamping mechanism having another movable clamping element and another cam configured for being rotated relative to the retainer support to linearly translate the other movable clamping element, thereby laterally securing the retainer within the plug base.
US08425533B2 Tissue retrieval device with pouch stretching arm
A tissue retrieval device comprises a tissue retrieval bag and resilient arms. The bag is releasably engaged with the resilient arms. One or two resilient arms expand the bag along a first plane to open the mouth of the bag. Another resilient arm expands the bag along a second plane to unfurl the bag. The first plane is substantially perpendicular to the second plane. The device further comprises a support tube having a passageway and a push/pull rod slidingly positioned within the passageway. The resilient arms are engaged with the push/pull rod such that the resilient arms and the push/pull rod travel uniformly relative to the longitudinal axis of the support tube. The arms collapse within the support tube and are resiliently biased to extend outwardly when the push/pull rod is translated distally relative to the support tube to expose the bag and arms.
US08425532B2 Method and apparatus for accessing the interior of a hip joint, including the provision and use of a novel telescoping access cannula and a novel telescoping obturator
A telescoping access cannula comprising: an outer tube; an inner tube carried by the outer tube, the inner tube being coaxial with the outer tube and longitudinally movable relative to the outer tube; and a rotatable member carried by the outer tube and connected to the inner tube, wherein rotation of the rotatable member causes longitudinal movement of the inner tube relative to the outer tube.
US08425524B2 Customized patient-specific multi-cutting blocks
A number of orthopaedic surgical instruments are also disclosed. A method, apparatus, and system for fabricating such instruments are also disclosed.
US08425522B2 Joint replacement method
Imaging of a left or right joint is performed preoperatively, and an alignment guide and a custom cutting guide are formed based on the imaging. The alignment guide includes cannulations into which pins are placed. The cutting guide is then aligned using the pins, and bone of the joint is cut, using the guide, in preparation for an implant operative to replace a portion of the joint. The cutting guide is provided with one or more slots or surfaces to aid in aligning a cutting instrument. The alignment guide or cutting guide may be modified to correct for an existing joint problem, for example an incorrect alignment of the joint. The alignment guide or cutting guide may be formed with polymeric material.
US08425519B2 Robotic arms
A device for treating fractures of a bone comprises a plurality of arms, each extending from a proximal end to a distal end and movable in a three-dimensional space, the proximal end of each arm coupled to a frame and a plurality of couplings, each of the couplings coupled to a distal end of each of the plurality of arms, the coupling lockingly receiving a bone fixation element secured to a corresponding bone fragment such that each of the arms is coupled to a corresponding fragment of the bone in combination with a mechanical unit moving each of the arms relative to the frame and a controller receiving data corresponding to a desired final position of the fragments relative to one another and controlling the mechanical unit to move the arms relative to one another to achieve the desired final position of the bone fragments relative to one another.
US08425511B2 Clamp and scissor forceps
A forceps includes a housing having a shaft attached thereto and an end effector assembly disposed at a distal end of the shaft, the end effector assembly includes first and second jaw members disposed in opposed relation relative to one another. At least one of the jaw members is moveable relative to the other between a spaced-apart position and an approximated position for grasping tissue therebetween. Each of the jaw members includes first and second longitudinal jaw halves. At least one of the first and second jaw halves of each jaw member is moveable with respect to the other jaw half between an aligned position and a displaced position for cutting tissue disposed between the jaw members.
US08425500B2 Method and apparatus for protecting capillary of laser fiber during insertion and reducing metal cap degradation
A method and an apparatus according to an embodiment of the invention includes disposing a cover about a capillary used in a side-firing optical fiber. The cover can be used to protect the capillary when being inserted through an endoscope for medical treatment. In some embodiments, the cover can be a low-profile cover such as a coating made of a light-sensitive polymer or like material. At least a portion of the coating can be removed after insertion by exposing the light-sensitive material to laser energy transmitted from an optical-fiber-core end housed within the capillary. In other embodiments, the cover can be a slideable or moveable low-profile sleeve or metal cover. During insertion, the sleeve or metal cover is positioned over the capillary. After insertion, the sleeve or metal cover is retracted to expose the area to be treated to side-fired laser energy transmitted from the capillary.
US08425498B2 Apparatus for treatment of material, in particular for refractive surgery
A device and a computer program for material processing, in particular refractive eye surgery, operate with a pulsed femtosecond laser and the individual focal points are positioned in such a way that the spacings of neighboring focal points for the most part vary, in order to avoid a regular grating structure avoiding undesired diffraction phenomena.
US08425495B2 Multipurpose diode laser system for ophthalmic laser treatments
A laser device and method for treating ophthalmic diseases is enclosed. The laser device and method for treating a variety of ophthalmic diseases comprises a system for irradiating the eye with electromagnetic irradiation with a wavelength in the range of 654-681 nm from at least one high power laser diode. The optical system of the present invention being able to focus the radiation onto a spot sized of about 100 μm. The system preferably comprises a laser source and ancillary equipment to direct and regulate the radiation. The use of this wavelength range makes the present invention effective for a wide variety of ophthalmic indications. It is capable of providing photocoagulation treatments for diseases such as glaucoma, diabetic retinopathy and age-related macular degeneration.
US08425490B2 Dynamic liposculpting method
A method of liposculpting a predetermined body area which is adjacently associated with at least one muscle bundle resulting in a natural, defined appearance of the muscle bundle. A treatment area from which fat tissue is removed by suction is at least partially defined by determining positions of the muscle in at least a relaxed state and a flexed or contracted state. Dependent on the particular physical characteristics of the affected muscle bundle, the flexed state can be defined by an isometric contraction as well as an isotonic contraction of the associated muscle bundle. The naturally defined appearance is accomplished by removing variable quantities of fat tissue from different portions of the treatment area, to the extent that greater quantity of fat tissue remains within the treatment area in a direction towards the substantial center of the muscle bundle and a gradually, successively lesser quantity of fat tissue remains within the treatment area in a direction away from the muscle bundle.
US08425488B2 System and method for the simultaneous bilateral treatment of target tissues within the ears using a guide block structure
Systems and methods for treating a patient having a head with a first ear and a second ear, function by mounting a support structure to the head of the patient; aligning the support structure with a target tissue in an ear canal of the first ear; stabilizing the support structure relative to the target tissue by injecting a material into the canal and hardening the material; and actuating a device while the device is supported by the support system so that the device therapeutically remodels the target tissue of the first ear.
US08425487B2 Drug vial spikes, fluid line sets, and related systems
This disclosure relates to drug vial spikes, fluid line sets, and related systems. In some aspects, a fluid line set includes a frame, multiple spikes extending from the frame, and multiple fluid lines connected to the frame. The frame is configured to hold the fluid lines in a spaced apart configuration.
US08425483B2 Double gusset cloth diaper along with method for making the same
A double gusset cloth diaper including an inner surface and an outer surface forming an hourglass shape, having a groin area proximate a center line of the reusable diaper and defining at least one recess therebetween. A fluid absorbent material is removably located in the recess through the opening. A first gusset is attached to the reusable diaper to form a first seal between the inner surface and the legs of the user. A second gusset is attached to the reusable diaper proximate the first gusset. The gussets are formed of an elastic material attached to the wrong side of the inner surface in a channel formed by stitching the inner surface to form channels.
US08425480B2 Location of fatty acid esters on tampons and toxin inhibiting efficacy
The application of active ingredients, exemplified by GML, to absorbent fibers, such as rayon fibers, used in tampon manufacture at very low levels has been found to maintain efficacy in the inhibition of the production of toxic shock syndrome toxin one (TSST-1) produced by S. aureus without overtly killing the microorganism to achieve the desired reduction while avoiding undesired test results that suggest the presence of “impurities” in some jurisdictions.
US08425475B2 Sanitary apparatus for intestinal cleansing
A sanitary apparatus for intestinal cleansing to be attached to a water faucet (R), comprises a faucet filter (2), a quick coupling (3) connectable to the faucet filter (2) and containing a pressure-relief device. A spiral hose (4) connects the pressure-relief device to a series of devices situated in a rectilinear tube section (16), the series of devices including a temperature control device (5), a flow regulator (6), a metering device (7), a check valve (13) and a rectal nozzle (14) in an end section of the sanitary apparatus. Said end section comprises a semirigid tube (9, 12) sustained by a fixing removable support (10) including a base plate (19) provided with at least a sucker (21) in its lower part, and with U bolt-shaped members (24) clamping the semirigid tube (9, 12) in its upper part.
US08425467B1 Catheter tube anchoring device
A catheter tube anchoring device for securing a catheter to a patient's skin, having two flexible side members and a rigid cross-member therebetween to which a retainer is mounted. The retainer holds a catheter adaptor at a 3-degree angle for patient comfort. Two rigid gripping tabs secure to each retainer side are gripped gripping while advancing a needle into the patient's vein and while attaching the catheter adaptor to a I.V. tubing, for increased patient comfort, reduction of the risk in contamination and patient infection, and to more easily and quickly start an I.V. An alternative embodiment includes prism shaped tabs containing a pressure-release polymer adhesive-containing capsules which releases the polymer adhesive through mesh openings in the tabs onto an absorbent pad on a crosslmember bottom side and onto a patient's skin to secure the device thereto either alone or in combination with a second adhesive on the patient's skin.
US08425463B2 Anesthetic injection system
Systems for injecting fluids and/or other materials into a targeted anatomical location, in particular, an intra-articular space, include a handpiece assembly having a proximal end and a distal end, a needle extending from the distal end of the handpiece assembly, a fluid delivery module comprising a cassette and a fluid transfer device. A conduit is generally configured to place the fluid delivery module in fluid communication with the handpiece assembly. Medications, formulations and/or other fluids or materials contained within vials that are secured to the fluid delivery module can be selectively delivered into an anatomy through a needle located at the distal end of the handpiece assembly. In some embodiments, ultrasound or other imaging technologies can be used to locate a joint or other targeted anatomical location.
US08425462B2 Devices, systems, and methods for medicament delivery
An apparatus includes a housing, a medicament container, an actuator, and a biasing member. The actuator is configured to move the medicament container within the housing when the actuator is moved from a first configuration to a second configuration. The actuator includes a gas container and a puncturer. When the actuator is in the first configuration, a portion of the puncturer is disposed apart from the gas container. When the actuator is in the second configuration, the portion of the puncturer is disposed within the gas container. The gas container has a longitudinal axis offset from a longitudinal axis of the medicament container. The biasing member is configured to bias the actuator toward the second configuration.
US08425456B2 Compliant balloon catheter
A catheter includes a first expandable membrane having a first pressurization limit and a second expandable membrane, having a second pressurization limit, wherein the second pressurization limit is greater than the first pressurization limit, the first expandable membrane defines a cooling chamber, the second expandable membrane being disposed around the first expandable membrane to define an junction therebetween. The catheter includes a coolant injection lumen in fluid communication with the at least one fluid inlet port and the cooling chamber, and a primary coolant return lumen in fluid communication with the at least one fluid outlet port and the cooling chamber. The coolant injection tube, the cooling chamber, and the primary coolant return lumen define a first fluid pathway. The catheter further includes a secondary coolant return lumen in fluid communication with the at least one fluid outlet port and the junction. The junction and the secondary coolant return lumen define a second fluid pathway. The catheter provides a fail-safe feature by selecting the appropriate first and second pressurization limits for the first and second expandable membranes.
US08425451B2 Gastrointestinal anchor compliance
A collapsible gastrointestinal anchor can be characterized in various embodiments by a radial force of about 0.1 Newtons (N) or greater at a compressed diameter of 25 millimeters (mm); by an average spring rate of about 13 Newtons/meter (N/m) or greater in a range of motion between a relaxed diameter and a compressive elastic deformation diameter; or by a radial force over the range of motion of about 0.1 N or greater. Typically, the anchor can be adapted to be retained within a subject's intestine, more typically in the duodenum, or particularly in the duodenal bulb just distal to the pylorus.A gastrointestinal implant device includes the collapsible gastrointestinal anchor and a floppy sleeve. The sleeve is open at both ends and adapted to extend into a subject's intestine, the anchor being coupled to a proximal portion of the sleeve.Also include are methods of implanting the gastrointestinal implant device in a subject, and methods of treating a subject for disease.The disclosed gastrointestinal invention leads to an improved ability to secure anchors and devices in the gastrointestinal tract while tending to minimize migration.
US08425449B2 Ocular implants and methods for delivering ocular implants into the eye
An ocular implant is provided. In some embodiments, the ocular implant includes a body that is curved about a longitudinal central axis and a distal body portion that defines a longitudinal channel including a channel opening. The implant is sized and configured such that the ocular implant assumes an orientation in which the channel opening is adjacent a major side of Schlemm's canal when the ocular implant is disposed in Schlemm's canal. Methods for delivering ocular implants into Schlemm's canal are also provided. Some methods include covering openings in the ocular implant, advancing the implant into Schlemm's canal while at least some of the openings are covered, and uncovering the openings while the distal portion of the implant is disposed in Schlemm's canal.
US08425448B2 Adjusting pH in a method of separating whole blood
This invention is directed to a method of collecting and separating whole blood into components. The method includes the steps of adding an anticoagulant having an acidic pH to a bag for collecting and/or separating whole blood, collecting whole blood in the bag, loading the bag containing anticoagulated whole blood on a rotor, spinning the bag on the rotor to separate the whole blood into at least one component; and squeezing the bag on the rotor to push the component from the separation bag into at least one satellite bag.
US08425447B2 Selective cytopheresis devices and related methods thereof
The present invention relates to systems and devices to treat and/or prevent inflammatory conditions within a subject and to related methods. More particularly, the invention relates to systems, devices, and related methods that sequester leukocytes and/or platelets and then inhibit their inflammatory action.
US08425444B2 Anti-clotting apparatus and methods for fluid handling system
Methods and apparatus are provided for determining the concentration of an analyte in a sample, such as an analyte in a sample of bodily fluid. In some embodiments, a method for maintaining clear passageways in an extracorporeal blood flow system includes intermittently providing one or more anti-clotting agents to a passageway of the extracorporeal blood flow system. In some embodiments, an extracorporeal blood flow system includes a passageway and a device operatively connected to provide one or more anti-clotting agents to a least a portion of said passageway.
US08425441B2 Spacer element for use in an orthopedic or prosthetic device
A spacer element for use in an orthopedic or prosthetic device includes a first region including first and second fabric layers spaced by a first compressible padding layer, a second region including first and second fabric layers spaced by a second compressible padding layer, and a third region including the first and second fabric layers adjacent one another. The first region is separated and spaced from the second region by the third region. The first padding layer has a greater density than the second padding layer, such that the first padding layer is less firm than the second padding layer.
US08425440B2 Orthotic capable of accepting replaceable supports for a pivoting joint of a human body
An orthotic for a joint of the human body, at which a body part pivots, includes first and second hinge members able to extend along respective posterior portions of body parts near the joint. The second member is able to be fitted with alternate orthotic support portions. A hinge connection joins the first member and the second member, permitting angular motion about an axis, and mutual disconnection and reconnection of the members at the hinge connection as the second member pivots relative to the first member.
US08425439B1 Locking and releasing hinge
A lockable hinge assembly configured for incorporation within a brace for stabilizing a joint includes a static support structure configured to remain in a fixed position, a dynamic support structure that is configured to be rotatable relative to the dynamic support structure, and a locking means for locking the dynamic support structure in a desired fixed position relative to the static support structure. The locking means is configured to enable the dynamic support structure to rotate relative to the static support structure and to automatically lock the dynamic support structure in a fixed position relative to the static support structure when the dynamic support structure rotates into the desired position.
US08425438B2 Motion assist apparatus
A motion assist apparatus is provided with an attaching member that has a glove shape with finger portions and a middle hand portion that is attachable to one of hands of a user, a back-side actuator that is freely expanded and contracted, and bridged between a tip of each of the finger portions and the middle hand portion on the back side of the attaching member, and a palm-side actuator that is freely expanded and contracted, and bridged between the tip of each of the finger portions and the middle hand portion on the palm side of the attaching member, and in this structure, the palm-side actuator is provided with a wire unit formed of two wires that are disposed on each of the finger portions on the palm side from the tip of each of the finger portions on the back side to the middle hand portion along the finger portion, passing through two side portions of the finger portion, so that intervals therebetween are made different at respective positions corresponding to joints of the finger portion, and rubber artificial muscle is coupled to the wire unit and is formed on the middle hand portion.
US08425437B2 Physical rehabilitation apparatus
A physical therapy device, in one form, provides rotation, flexion and stretching to rehabilitate patients undergoing physical therapy. The physical rehabilitation apparatus can comprise a base and a track coupled to the base with the track configured to slide along the base. The apparatus can further comprise a bearing coupled to the track, the bearing allowing rotational movement about an axis substantially perpendicular to the track and a tread coupled to the bearing. In one form, the apparatus works with a number of attachments.
US08425436B2 Motion assistive device and maintenance management system for motion assistive device
An operating status of a motor in a drive unit is analyzed to extend the life of the motor. A wearable motion assistive device 1 includes a shoulder joint mechanism 5 and an elbow joint mechanism 6 for aiding a movement of the shoulder joint and the elbow joint, and a control unit 100 having a control circuit for controlling drive units 11 for the shoulder and elbow joint mechanisms 5 and 6. The control unit 100 controls the drive units 11 based on a physical quantity and a biosignal detected by an angle sensor, a torque sensor, and a biosignal detecting sensor. A controller in the drive unit 11 includes a motor monitoring unit for monitoring an operational status of the motor, and a motor control unit for limiting a drive signal supplied to the motor based on a monitoring result provided by the motor monitoring unit, in order to prevent an overload state of the motor.
US08425434B2 Method and apparatus for monitoring animal condition
A method and system for monitoring the condition of animals provides for current height and weight measurements taken from an animal in order to automatically derive a height-to-weight ratio. The height-to-weight ratio thus obtained may be used to determine whether or not an animal's overall physical condition lies inside tolerance limits in relation to its predetermined expected development. An apparatus for implementing the method of the invention may include a control system configured to determine the height-to-weight ratio and may within a control system of an animal installation. The supply of feed to an animal may be adjusted in response to a deviation of its measured height weight ratio from a target or benchmark value.
US08425425B2 Virtual image formation method for an ultrasound device
Disclosed are ultrasound devices and methods for use in guiding a subdermal probe during a medical procedure. A device can be utilized to guide a probe through the probe guide to a subdermal site. In addition, a device can include a detector in communication with a processor. The detector can recognize the location of a target associated with the probe. The processor can utilize the data from the detector and create an image of a virtual probe that can accurately portray the location of the actual probe on a sonogram of a subdermal area. In addition, disclosed systems can include a set of correlation factors in the processor instructions. As such, the virtual probe image can be correlated with the location of the actual probe.
US08425424B2 Closed-loop clot lysis
The present invention provides procedures and systems that use a closed-loop approach for directing ultrasound energy at a clot while monitoring blood flow and/or liquification of the clot tissue so as to allow automated and/or manual adjustments to various treatment parameters.
US08425422B2 Adaptive volume rendering for ultrasound color flow diagnostic imaging
Adaptive volume rendering is provided for medical diagnostic ultrasound. The opacity of B-mode data is set relative to the opacity of Doppler data. The opacities for the different types of data are set as a function of ray depth. For example, the opacity of B-mode data near a tissue border is set to be more opaque than for tissue away from the border, and the opacity for flow data near a flow border is set to be less opaque than for flow away from the border. An image is rendered using a rendering parameter set as a function of ray depth, B-mode information and Doppler information. Other processes for enhancing and/or using rendering may be used.
US08425420B2 Bone strength diagnosing device and bone strength diagnosing method
The purpose of the current invention is to provide a bone strength diagnosing device and a bone strength diagnosing method capable of accurately diagnosing a bone strength of a bone. A longitudinal ultrasonic transducer and a transverse ultrasonic transducer radiate ultrasonic waves onto a bone front surface of a tibia from a predetermined angle to generate surface waves that propagate in the bone front surface in a longitudinal direction of the tibia and in a direction perpendicular to the longitudinal direction, respectively, and receive leaky waves leaking to the side of the soft tissues from the front surface waves. A speed-of-sound calculating module calculates speeds of sound of the surface waves in the transverse direction and the longitudinal direction based on a difference between course lengths of the ultrasonic waves and a difference between propagation times.
US08425418B2 Method of ultrasonic imaging and biopsy of the prostate
A system and method (i.e, utility) are disclosed for positioning a needle in three-dimensions based on patient related statistics for extracting tissue during biopsy procedures. Aspects of the utility can be applied independently or serve as an aid to the urologist when regions of interest are hard to discern in an ultrasound image. Regions of interest that correspond to high cancer risk regions (e.g., statistically) are automatically superimposed on an ultrasound image of a patient in real time. Additionally a statistical map based on one or more demographic parameters of a patient and containing cancer probability locations are also automatically mapped on the ultrasound image in real time displaying potential cancer locations. Aspects of the system are also capable of displaying optimal needle placement positions based on statistical priors and will be able to accurately navigate the needle to that position for biopsy extraction and/or treatment.
US08425416B2 Analyte sensor
Systems and methods of use for continuous analyte measurement of a host's vascular system are provided. In some embodiments, a continuous glucose measurement system includes a vascular access device, a sensor and sensor electronics, the system being configured for insertion into communication with a host's circulatory system.
US08425415B2 Health monitoring appliance
A heart monitoring system for a person includes one or more wireless nodes; and a wearable appliance in communication with the one or more wireless nodes, the appliance monitoring vital signs. Other implementations can monitor heart rate, heart rate variability, respiratory rate, fluid status, posture and activity.
US08425401B2 Gastric inflation band with integrated infusion catheter
An inflatable gastric band incorporates a fluid channel within an outer surface of the band and an inflatable bladder on a stomach-facing side of the band. The gastric band attaches to a double lumen catheter, which communicates with a dual infusion port. One lumen communicates with the fluid channel and one port, while the other lumen communicates with the inflatable bladder and a second port. Injection of fluid into one chamber of the infusion port expands inflatable bladder, allowing adjustment to the diameter of the stoma. Injection of drugs or therapeutic agents into the second chamber allows the infusion of drugs or agents directly into the abdominal cavity of a gastric band recipient. The inflatable bladder can be continuous or segmented. A segmented bladder reduces pinching and/or folding of the inner surface of the gastric band during expansion/contraction, thereby lessening stomach pinching and/or irritation.
US08425400B2 Implant for supporting the urethra of a man and a surgical kit for treating incontinence in a man and including such an implant
An implant for supporting a urethra of a man which includes two elongate flexible strips that are substantially inextensible in length between opposite ends thereof and that include middle portions that are disposed adjacent to one another in side by side relationship such that a side edge of each strip faces towards the other strip, and wherein the strips are connected to each other at the middle portions, and wherein the strips have intermediate portions that extend between the middle portion and each opposite end of each strip along which the strips are separate from each other. The implant supports the urethra in such a manner that the two strips may be placed under tension independently of each other with the middle portions thereof supporting the urethra over a total width of the strips.
US08425399B2 Focusing board assembly for medical imaging equipment
A focusing board assembly for a medical imaging equipment gives a comfortable feeling mentally or physically by visually getting rid of an oppressive feeling arisen when a patient is in a tunnel-like enclosed space such as MRI or CT for his/her medical examination.
US08425394B2 Centrifugal separator with lubrication device
The invention relates to a centrifugal separator having a bearing device and a lubricating device comprising a rotatable pump device. The pump device comprises a lubricant inlet to receive lubricant from a lubricant reservoir, and a duct to convey lubricant to an outlet device for delivering at least part of said lubricant in the form of lubricant mist through at least one lubricant outlet. The pump device further comprises a gas inlet and the outlet device comprises a gas outlet, whereby during rotation of the pump device a gas flow is maintained from the gas inlet to the gas outlet bringing along lubricant present in the duct towards the outlet device. The centrifugal separator further comprises a housing which surrounds the bearing device and the lubricating device and which allows lubricant mist to pass from the lubricating device to the bearing device in order to lubricate the latter.
US08425392B2 Broadsheet newspaper printing press and folder
A broadsheet newspaper printing press has at least one print unit printing at least one web of material and a folder. The folder has a cross-cutter to cut the web of material into broadsheet newspapers, a tucker cylinder having a gripper gripping the broadsheet newspapers at a lead edge and a tucking blade for forming a cross-fold in the broadsheet newspapers, and a jaw cylinder or fold rollers to receive the cross-folded broadsheet newspapers from the tucker cylinder at the cross-fold, the gripper being located with respect to the tucking blade so that the cross-fold is located at between 33% and 45% or 55% and 67% of the height of the newspaper.
US08425389B2 Method and a system for manufacturing printed products
For manufacturing books having different sizes and comprising a plurality of text pages constituting a book block, a web of material having a given width is sequentially printed in a digital printing station. The printed web of material is then provided either with one weakening line extending parallel to the longitudinal direction of the web of material or with two weakening lines arranged spaced apart and extending parallel to the longitudinal direction of the web of material. Thereafter the printed web of material is transversely cut to produce individual text sheets which are provided with either one weakening line or two weakening lines. These text sheets are then longitudinally folded along the either one weakening line or in sequence along each of the two weakening lines. The folded text sheets belonging to a particular book block are stacked to a stack. The stacks are either temporarily stored for a later binding process or directly supplied to a binding station.
US08425387B1 Method for manufacturing stair step portfolio file
A stair-step, expandable file folder is disclosed, in which each pocket in the folder has the same depth, rather than the back pockets being deeper than the front pockets. The folder is formed from a group of attached dividers. Each divider in the group is generally planar and includes two horizontal folds near a bottom edge of the divider. The divider area above the folds forms a wall of a pocket. The divider area between the folds extends to an adjacent divider and forms the bottom of the pocket. The divider area below the folds is attached to the adjacent divider. The adjacent divider forms an opposing wall of the pocket. When the group of dividers is compressed front-to-back, the dividers all have the same lateral footprint. When the group is expanded front-to-back, the dividers translate vertically, so that the tops of the dividers are all visible simultaneously from the front of the folder. During manufacturing, the group of dividers may be tilted front-to-back to ensure that the bottoms of the pockets remain in contact with their respective tooling elements.
US08425380B2 Engine controlling apparatus for motorcycle
An engine controlling apparatus for a motorcycle for reducing the output power of the engine when necessary includes a second controller for deciding, if a brake operation is detected based on an opening value of an accelerator grip detected by a potentiometer for detecting an opening value of the accelerator grip that the accelerator grip is in an open state, whether it is necessary to reduce the output power of an engine and for carrying out output power reduction control of the engine. If a front wheel brake sensor detects a brake operation for the front wheel and in addition it is decided from the speed value detected by a vehicle speed sensor that the motorcycle is not being decelerated, then the second controller decides that there is the necessity to reduce the output power of the engine and carries out the output power reduction control of the engine.
US08425372B2 Geared turbofan emergency power
A gearbox has a first rotative component and a second rotative component, the gearbox having a rotary input and a rotary output, a first brake for braking the first rotative component of the gearbox against rotation thereof, and a second brake for braking the second rotative component of the gearbox against rotation thereof. The rotary input drives the rotary output if the first brake brakes the first rotative component of the gearbox and the rotary output drives the first rotative component of the gearbox if the second brake brakes the second rotative component of the gearbox.
US08425371B2 Multi-speed transmission having three planetary gear sets
A transmission is provided having an input member, an output member, three planetary gear sets, a plurality of coupling members and a plurality of torque transmitting devices. Each of the planetary gear sets includes first, second and third members. The torque transmitting devices include clutches and brakes.
US08425369B2 Multi-speed transmission
A transmission has an input member, an output member, four planetary gear sets, a plurality of coupling members and a plurality of torque transmitting devices. Each of the planetary gear sets includes first, second and third members. The torque transmitting devices include clutches and brakes. The torque transmitting devices are each selectively engageable in combinations of at least two to establish at least ten forward speed ratios and at least one reverse speed ratio.
US08425366B2 Multi-speed transmission having three planetary gear sets
A transmission is provided having an input member, an output member, three planetary gear sets, a plurality of coupling members and a plurality of torque transmitting devices. Each of the planetary gear sets includes first, second and third members. The torque transmitting devices include clutches and brakes.
US08425365B2 Planetary layshaft transmission
A transmission is provided having an input member, an output member, at least one planetary gear set, a plurality of transfer gears connected by a layshaft, a plurality of coupling members and a plurality of torque transmitting devices. Each of the planetary gear sets includes first, second and third members. The torque transmitting devices include clutches and brakes.
US08425364B2 Cam-based infinitely variable transmission
A cam based infinitely variable transmission incorporation a ratcheting drive mechanism with one set of planetary gears and a cam with two followers mounted on a carrier with said gears and adapted to in infinitely variable in output but maintain a uniform output for a given uniform input. The followers are can be shifted in relation to the three dimensional cam by a shifter and clutches are used to handle the relative motion of the gears and follower shafts.
US08425357B2 Double cogged V-belt for variable speed drive
A double-cogged V-belt with the upper and lower cog profiles symmetric and having lines (“L”) and arcs (“A”) connected according to a sequence from the center of a root to the center of an adjacent cog of L1-A1-L2-A2-L3 for the upper profile and A3-L5-A4-L6, and with at least one upper root and one lower root substantially aligned with each other, and with the sum of the length of L1 plus the radius of A1 equal to or within 20% of the radius of A3. The upper and lower pitches may be equal and all the roots aligned, or there may be more upper cogs than lower cogs. Some or all arcs and lines may be connected tangentially.
US08425354B2 Implantable locator for hunting arrows
A hunting arrow for tracking target animals is disclosed and described. The arrow can include a chamber having an angled surface and a compression fitting surface. The arrow can also include a transmitter housing having an angled surface and a compression fitting to securely house the transmitter within the chamber during flight. The transmitter may include removable parts, to enable reuse of the transmitter, including but not limited to: compression fittings, barbed hooks, an attachment assembly and a battery cover. The transmitter is ejected from the chamber when the arrow strikes a target animal and the one or more barbed hooks stops the forward momentum of the transmitter with sufficient force to overcome the friction between the compression fitting and the compression fitting surface within the chamber, thereby ejecting and embedding the transmitter in the hide of the animal. Alternatively, or in addition thereto, the hunting arrow can include a plunger system, retaining member/retaining dimple system and/or an adhesive strip system to secure the transmitter to the arrow during flight.
US08425353B2 Customizable bat
A customizable bat is described. The customizable bat may have a handle and a knob detachably affixed to an end of the handle by way of a knob-shaft inserted into a channel of the end of the handle. A pin may extend centrally from a top of the knob through the knob-shaft toward the handle. The pin may be shaped to engage with the knob of the customizable bat. The bat may also include a customizable marker that indicates information associated with the bat. The customizable marker may be removably integrated with the top of the knob and the pin of the bat. The customizable marker may be configured to securely fit around the pin of the bat.
US08425351B2 Golf ball having deflection differential between inner core and dual core
A golf ball comprising a core comprising an inner core center and an outer core layer disposed over the inner core center. The inner core center has a deflection of greater than 0.210 inch under a load of 100 kilograms and the core has a deflection ranging from 0.120 inch to 0.095 inch under a load of 100 kilograms. A mantle layer is disposed over the core and a cover is disposed over them mantle.
US08425345B2 Variable length shaft
A variable length golf club shaft is disclosed herein. The variable length golf club shaft includes at least one upper shaft portion having a first diameter and a hollow lower shaft portion having a second diameter that is larger than the first diameter, wherein the lower shaft portion has at least one notch, and wherein the at least one upper shaft portion has at least one pin that fits within the at least one notch.
US08425343B1 Golf swing and golf putting stroke alignment aid
The golf swing and golf putting stroke alignment aid consists of a tripod stand from which a horizontal member attaches and extends outwardly therefrom. A detachable alignment member attaches onto a distal end of the horizontal member, and touches on different surfaces of a golfer to provide an alignment aid for use with a putting stroke or golf swing. The alignment aid is able to give instantaneous feedback to the golfer of proper alignment of a surface of the head, arm, or hand at a particular location along the path of the golf swing or putting stroke. The tripod enables vertical adjustment of the horizontal member, which can rotate thereon in order to provide adjustment of the height and location of the detachable alignment member with respect to the surface of the golfer.
US08425342B2 Putter heads and putters including polymeric material as part of the ball striking face
Golf clubs and golf club heads, such as putter heads, may include a putter body and an insert forming a ball striking face and engaged with the putter body. Portions of the insert may be formed of a metal material, while portions of the insert may be formed of a polymer material. The insert may include a base portion having grooves or openings formed therein. This base may be joined with another material (such as a polymer backing material) to form the insert, wherein the backing material at least partially fills the grooves or openings. In some arrangements, the backing material of the insert may be visible at the top and/or bottom surfaces of the putter structures. Methods for making such putter devices are also described.
US08425339B2 Systems and devices of enhancing power grip on an athletic apparatus
The disclosed systems and devices of enhancing power grip on an athletic apparatus allow for a constant pressure by the thumb and index finger to be applied to the golf club. The enhanced grip of the left thumb and index finger is sufficient to maintain proper grip during the golf swing and, most importantly, at impact. The disclosed systems and devices of enhancing power grip on an athletic apparatus comprise an index finger support, a thumb support and a locking mechanism. In an example embodiment, the index finger support comprises a slight curvature (or bevel) which allows this portion of the grip to be on the underside of the golf club. The thumb portion of the grip may be straight, exerting pressure on the top portion of the golf club.
US08425338B2 Inflatable sealed air support device
A sealed air support structure including at least one sealed air chamber. The at least one sealed air chamber includes at least a first side support and a second side support, each having a support end and a base end. The at least one sealed air chamber includes a main beam with a first end coupled with the support end of the first side support and a second end coupled with the support end of the second side support. A first plurality of connectors coupled with the base end of the first side support and a second plurality of connectors coupled with the base end of the second side support are configured to detachably couple with a plurality of connectors disposed on a cold-air inflatable structure. The at least one sealed air chamber is configured to support a weight applied to the main beam.
US08425337B2 PVC shell skatepark
A skate park has a hard top shell formed with skate features drawn down from a top surface of the hardtop shell. The hard top shell has a thickness between 0.2 mm and 1 mm. The hard top shell has a hard top shell inside surface. The hard top shell is pervious to light. A sidewall is formed on a side of the hardtop shell. A paint layer is disposed on the hard top shell inside surface. The skate park may have at least one half pipe. A foil layer may be laminated to the underside of the hardtop shell. The skate park preferably includes at least one bowl recess, but may have two bowl recesses joined at a connecting ridge.
US08425333B2 Torque limiter
In a spring type torque limiter, it is proposed to prevent cut end portions of a coil spring fitted on an inner ring from causing chatter of the torque limiter, even if the cut end portions of the coil spring are separated from a radially outer surface of the inner ring in order to prevent burrs remaining on the cut end portions of the coil spring from contacting the radially outer surface of the inner ring. The first cut end portion of the coil spring fitted on the inner ring is inserted in a recess of a first spring receiving protrusion formed on the radially inner surface of the outer annular member. The second cut end portion is inserted in a recess of a second spring receiving protrusion formed on the inner surface of the lid member, thereby restraining the first and second cut end portions with the recesses.
US08425331B2 User interface for viewing aggregated game, system and personal information
A user interface for displaying a user profile in a gaming console that communicates to a remote service. A “Gamer Profile” is created that serves as a building block for services and applications that aim to create a social community of gamers and grow relationships among players. In accordance with the present invention, the Gamer Profile is the entirety of information (e.g., metadata) related to a specific user. The Gamer Profile is developed from a set of services that collect and expose this information in a meaningful way to the community. Feedback information may be included that is provided by other users to further enhance the profile. The Gamer Profile also provides for personalization such that users can customize their gaming experience.
US08425325B2 Automatically generating a book describing a user's videogame performance
Systems and methods are provided that record data in a videogame, such as a user's character and performance in the videogame, and generate a book, e-book, or comic book based on the recorded data. A narrative data structure generated from the recorded data may include pregenerated text and images, and may provide for insertion of the recorded data into the narrative data structure. The recorded data may be converted into natural-language text for insertion into the narrative data structure. In some embodiments, the system may record screenshots of the videogame and insert the screenshots into the narrative data structure as illustrations. The narrative data structure may be provided to a location for printing as a book or other publication or may be electronically formatted and provided as an e-book.
US08425323B2 Wagering game with asset trading
Method and system are disclosed for operating a wagering game terminal where players are allowed to transfer game assets that they may have accumulated to other players. The game assets may be transferred as part of an on-line auction won by one of the other players, as a gift to a preselected player, or as part of a trade with a preselected player. Neither the transferring player nor the receiving player is required to be present at a wagering game terminal at the time of the transfer. The transfer may be an anonymous transfer or it may be an identity-based transfer. For identity-based transfers, a predefined list of selected players may be used to facilitate the transfers.
US08425320B1 Variable sensor based gated shifter convertible to sequential shifter mode
A transmission-gear-selection device includes knob means; shaft means coupled to the knob means; and shift means coupled to the shaft means and configured to shift gears for a driving simulator and/or driving game as the knob means and shaft means are manipulated by a user, wherein the knob means and shaft means are configured to be manipulated for gated shifting. Gated shifting includes the simulation of a transmission of a vehicle that is simulated by the driving simulator and/or the driving game.
US08425318B2 Multiple wagering game displays from single input
A wagering game system and its operations are described herein. In embodiments, the operations can determine different objects and/or portions within a wagering game video image and split the wagering game video image into multiple video streams containing different parts of the wagering game video image. The operations can then present the multiple video streams on multiple displays. The multiple displays can show the different parts of the wagering game video image appearing as separate and distinct video images. In some embodiments, some of the multiple displays can be placed in front of other displays. The operations can generate transparent masks that allow images to be seen through a display.
US08425316B2 Methods and systems for improving play of a bonus game on a gaming machine and improving security within a gaming establishment
Methods and Systems for improving play of a bonus game on a gaming machine and improving security within a gaming establishment are described. The systems include a gaming machine, which includes an input device that receives an input from a user. The gaming machine further includes a first display device that displays a primary game upon receiving the input, and a second display device including a multilayer display that displays a secondary game. The multilayer display includes a foreground screen and a background screen, with at least a portion of the foreground screen or the background screen being curved and the foreground screen or the background screen displays an image of a wheel. The gaming machine further includes a controller configured to execute the primary and secondary games. The secondary game is played after playing the primary game.
US08425312B1 Playing card indentification system
A method determines the three-dimensional position of a playing card at a distance from a gaming table. The method uses modulated signals incorporating different power levels or different frequencies and can be employed as the cards are being dealt or using cards with more than one transponder. The method includes steps of providing each card with at least one transponder that transmits a card identity signal when activated; transmitting an activating signal modulated as to frequency or energy; forming detection zones up to plurality of distances above the gaming table; receiving at a system computer the unique card identity signal; determining a three-dimensional location of the card above the gaming table; recording and displaying the card activity on a computer monitor screen.
US08425311B2 Method of awarding a bonus prize in the play of a plurality of gaming machines
By awarding bonuses during predetermined bonus periods, gaming establishments can exercise greater control over bonus wins and, in doing so, can create player excitement and increase play during historically off-peak times, realizing greater revenue for the casino. The time based bonus begins when a maximum time for the bonus period is selected and divided into time increments, with each time increment having its own weight. A winning increment is randomly selected and a bonus is awarded when the time increment has been reached.
US08425310B2 System and method for tracking patrons non-gaming casino spend
A system and method for tracking patron events at a plurality of devices is provided. The plurality of devices include electronic gaming machines and non-gaming machines. Each game device has a value associated therewith. The system includes a plurality of player tracking devices and a server or computer. Each player tracking device is associated with one of the electronic gaming machines. The player tracking devices identify patrons interacting with the system, track wagers made by the patrons on the electronic gaming machines and record wager data associated with each wager made by the players and a respective electronic gaming machine in a database. The server receives the wager data and stores the wager data in a database and receives transaction data associated with a transaction associated with the patrons use of the non-gaming devices and stores the transaction data in the database, and establishes a player rating associated with each player as a function of the wager data and the transaction data.
US08425308B2 Counter-balancing in-play video game incentives/rewards by creating a counter-incentive
An approach is provided in which a disincentive is provided during the execution of a video game program that is operated by a current user. One or more disincentive factors are identified that correspond to the current user. The identified disincentive factors are compared with current time factors. Based on the comparison, one or more game characteristics are altered with the game characteristics being altered in order to provide a disincentive to continued operation of the video game program by the current user.
US08425304B2 Gaming system having graphical feature interface
A gaming system comprises a wager input device for receiving a primary wager and a display for displaying a primary wagering game. The gaming system further comprises a controller which is operative to (i) detect receipt of the primary wager, (ii) display a randomly selected outcome of the primary wagering game, (iii) display a feature icon on the display, (iv) detect selection of the feature icon, (v) in response to the selection of the feature icon, display a feature menu on the display, the feature menu displaying a plurality of available features capable of activation in addition to the wagering game, and (vi) in response to a first feature of the feature menu being selected, activate and display the first feature if a first eligibility requirement is satisfied.
US08425301B2 Gaming system and a method of gaming
The present invention relates to a gaming system and to a method of gaming. A gaming system comprises a game controller arranged to randomly display several symbols from a predetermined set of symbols and to determine a game outcome such as a game win based on the displayed symbols. Such gaming systems may be implemented as a stepper machine provided with reels or a video machine displaying “virtual” reels. One or more reels generated in play of a base game may be stored for later use in subsequent games. In a subsequent game or games, the game controller may select the stored reel to substitute for a reel generated by the game, in order to improve the game outcome. For example, the game outcome may become a “win” from a “lose” outcome. Or it may result in an improved win outcome. The one or more reels may be stored depending upon a trigger condition generated in the base game.
US08425299B2 Apparatus for providing amusement
Certain non-limiting exemplary embodiments are taught which include a game comprising, a digital processor, digital storage coupled to the digital processor for storing instructions, a display coupled to the digital processor displaying a first plurality of indicia arranged in a plurality of rows and a plurality of columns such that there are a plurality of paylines through a contiguous plurality of indicia, a user interface coupled to the digital processor to select a subset of the first plurality of indicia taken along at least one column and to initiate a display of a second plurality of indicia which includes the selected subset of the first plurality of indicia on the display, and an award dispenser providing an award which is at least as large as the largest award associated with the plurality of paylines.
US08425298B2 Gaming system, gaming device and method for draw poker game
A gaming system, a gaming machine and a method is provided having a five card video draw poker game with multiple hands. An initial five card hand is displayed to the player face-up. The player then chooses which of the initial five cards to discard. Each card that is held is then duplicated into all of the other hands to be played. Replacement cards for the unheld cards are displayed and each hand is completed to have a final five card hand. The poker hand ranking of each final five card hand is determined and winning hands receive an award. The player also receives an additional award depending on the number of final hands that fall into each poker hand category.
US08425297B2 Method and apparatus for conducting a game of chance including a ticket
A system and method are provided for playing a game of chance. The game of chance may include, for example, a lottery-type game. A result of the game of chance is revealed to a player in another medium. In one example, the result is revealed during multiple game instances of one or more online games. In one example, the online game includes a poker game, such as, for example, a pai gow poker game. In a version of this embodiment, the poker game provides for a player to arrange a plurality of cards dealt to the player into a first hand and a second hand. In another example, the poker game is coupled with a second level game in which the result is revealed. In a specific example, the second level game is a slot machine game.
US08425292B2 System and method for analyzing postures
A posture analyzing system has a collecting apparatus disposed on a handle of a sports apparatus and is configured to collect and transmit data of the sports apparatus. A mobile terminal is configured to read the data and to draw a moving path of the sports apparatus according to the data and shape of the sports apparatus. Further, a posture analyzing system collects and sends data of the sports apparatus by a collecting apparatus disposed on a handle of the sports apparatus and receives the data and draws a moving path of the sports apparatus according to the data and shape of the sports apparatus by a mobile terminal.
US08425287B2 In-row air containment and cooling system and method
An in-row electronic equipment storage system and corresponding method provides cooling to an electronic equipment rack. The system includes an electronic equipment rack that includes a housing adapted to receive electronic equipment, and an electronic equipment rack air cavity. A cooling rack, including a housing adapted to receive cooling equipment, and a cooling rack air cavity, is configured to be disposed adjacent to the electronic equipment rack. An interface allows for fluid communication between the cooling rack air cavity and the electronic equipment air cavity. The interface may include dampers to control air flow between the air cavities.
US08425286B2 Quick release structures for a computer
Quick release couplings for releasably coupling components of a computer to the computer are disclosed. The quick release coupling mechanisms are generally configured to allow tool-less placement of the components relative to the computer. That is, the quick release coupling mechanisms are configured to perform their couplings without using conventional fasteners such as screws, bolts, etc. By eliminating the use of fasteners, the components may be inserted and removed from the computer without using tools (e.g., tool-less). Furthermore, the quick release couplings are easy to maneuver thereby enabling quick and straightforward assembly and disassembly of the components to and from the computer (e.g., quick release). For example, the components may be inserted and removed by a simple pushing or pulling motion, and/or by a simple flick of a latch or handle.
US08425280B2 Distributor for continuously feeding abrasive material in a water-jet cutting machine
A machine has a head with a nozzle, a pipe for supplying water under pressure to the nozzle, and a duct for supplying an abrasive agent, and adding it to the jet of water under pressure. The duct has a first duct portion, fixed with respect to the head in the movements of rotation about a main axis, and a second duct portion, which is fixed with respect to the movements of rotation. A rotating distributor connects the first rotating portion with the second fixed portion of the duct for supplying the abrasive agent. The distributor's stator and rotor are rotatably mounted on one another without the interposition of seal rings and define between them an internal chamber that is substantially at atmospheric pressure and from which the abrasive agent drops by gravity to a duct outlet that converges into the pipe for supplying water under pressure.
US08425276B2 Polishing composition
The present invention provides a polishing composition for polishing copper or copper alloy, comprising: an oxidizing agent (A); at least one acids (B) selected from amino acids, carboxylic acids of 8 or less carbon atoms, or inorganic acids; a sulfonic acid (C) having an alkyl group of 8 or more carbon atoms; a fatty acid (D) having an alkyl group of 8 or more carbon atoms; and an N-substituted imidazole (E) represented by the following general formula (1). (In the formula (1), Ra, Rb, and Rc represent H or an alkyl group of 1 to 4 carbon atoms, and Rd represents a group selected from the group consisting of a benzyl group, a vinyl group, an alkyl group of 1 to 4 carbon atoms, and a group in which a portion of H of these groups has been substituted with OH or NH2.)
US08425275B2 Body garment and shapewear design and method of use
A shapewear garment is described that includes a one-piece foundation, wherein the foundation comprises a compression material having at least one area of firm support and at least one area of light support; and at least one resealable thong-like seam.
US08425272B2 Laminated interconnects for organic opto-electronic device modules and method
A method of producing an encapsulated module of interconnected opto-electronic devices which comprises: forming a patterned anode layer; forming a layer of opto-electronically active material over the patterned anode layer; forming a patterned cathode layer over the layer of opto-electronically active material, to provide a device array of opto-electronically active cells on the substrate; selectively removing portions of the layer of opto-electronically active material so as to expose minor portions of the anodes; forming a patterned interconnect layer on an encapsulating sheet in a pattern to define an array of interconnect pads; and laminating the patterned encapsulating sheet over the array of opto-electronically active cells whereby the exposed anode portions are interconnected with the cathodes of adjacent cells by the interconnect pads and the interconnected cells are encapsulated by the encapsulating sheet.
US08425271B2 Phosphor position in light emitting diodes
A method of forming an LED lamp with a desired distribution of phosphor is disclosed. The method includes the steps of mixing a plurality of phosphor particles in an uncured polymer resin for which the viscosity can be controlled in response to temperature to form a substantially uniform suspension of the phosphor particles in the resin. The uncured resin is then placed into a defined position adjacent an LED chip and the temperature of the resin is increased to correspondingly decrease its viscosity but to less than the temperature at which the resin would cure unreasonably quickly. The phosphor particles are encouraged to settle in the lowered-viscosity resin to a desired position with respect to the LED chip, and the temperature of the resin is thereafter increased to the point at which it will cured and solidify.
US08425270B2 Length-adjustable tie bar for marine engines
The present invention relates to a tie bar. The tie bar has a first subassembly and a second subassembly. The first subassembly includes an end portion configured to connect to a propulsion unit, a first tube that extends from the end portion and a threaded member operatively connected to the end portion and disposed within and at least partially extending along the first tube. The second subassembly includes an end portion configured to connect to a further propulsion unit and a second tube that extends from the end portion of the second subassembly. The second subassembly is configured to threadably engage with the threaded member. The distance of separation between the end portions is selectively adjustable thereby.
US08425269B2 Multi-function auxiliary rudder system for jet propelled watercrafts
A rudder system that uses a dual purpose thrust operated actuator. The actuator is selectively positioned for use in an up or constant down mode. While in the up mode, the actuator uses the force of the jet pump to raise the rudders out of the water at speed, and with the actuator set in the down mode, the invention uses the force of the jet pump water to hold the rudder in the water. In an alternative embodiment, the invention includes anti-oscillating veins attached to the thrust operated actuator. In another alternative embodiment, the travel of the actuator is limited by configuring it to come into contact with a rudder stabilizer bar. Another embodiment includes providing adjustable fin positions relative to the side force stabilizer.
US08425261B2 Electrical connector with contact spacing member
A contact sub-assembly is provided for an electrical connector. The contact sub-assembly includes a base having a base surface, and an array of contacts that extend along the base surface of the base. Each contact extends along a length from a terminating end to a tip end. Each contact has a mating interface located along the length of the contact between the terminating end and the tip end. The contact sub-assembly also includes a spacing member formed separately from the base. The spacing member engages at least some of the contacts for positioning the contacts relative to each other within the array. The spacing member includes first and second spacing segments that are discrete from each other and that are configured to move relative to each other.
US08425259B2 Vandal proof NMO antenna mount
An antenna mount is provided including a contact pin having first and second distal ends, a barrel encasing the contact pin, a base encasing the barrel, a terminal lug press fit within a cross-section of the base, and a set screw receptacle disposed in a portion of the base for receiving a set screw to secure an antenna to the base. The first and second distal ends of the contact pin extend past first and second distal ends of the barrel, the first distal end of the contact pin extends past a first distal end of the base, and a second distal end of the base surrounds the second distal end of the pin.
US08425253B2 Center conductor terminal having increased contact resistance
A terminal assembly is provided for terminating a center conductor of a coaxial cable. The terminal assembly includes a terminal body having a pin at one end and a cavity at the other end for accommodating a center conductor therein. A contact member is supported within the cavity. The contact member includes plural inwardly directed cantilevered beams extending from a contact base for deflectable engagement with the inserted center conductor. The terminal body includes an inwardly directed shoulder for engagement with the beams at a location between the base and the distal ends of the beams. The location defines a deflection fulcrum at a location distal from the base so as to provide increased contact engagement force between the distal ends of the beams and the center conductor.
US08425251B1 Assembly for relieving cable bundle connection strain
An assembly for relieving cable bundle connection strain, the cable bundle being electrically connected to and extending from a multi-terminal modular plug, the assembly including a receptacle receiving the multi-terminal modular plug, the receptacle having a cable receiving nipple; clamping set screws connected operatively to the receptacle's lateral and oppositely lateral walls for securing the multi-terminal modular plug within the receptacle; a cable extension port opening the receptacle, the cable extension port receiving the cable bundle's extension; a cable sheath, the cable bundle's extension being further received by the cable sheath; and a constant force spring annularly clamping the sheath about the receptacle's nipple.
US08425246B1 Low profile semiconductor device socket
Various circuit board sockets and methods of manufacturing and using the same are disclosed. In one aspect, a method of manufacturing is provided that includes forming a socket operable to receive a first circuit board. The socket includes a housing and a cover slidedly coupled to the housing. The cover has an opening sized to enable the first circuit board to seat on the housing.
US08425245B2 Fastener for an electrical connector
The invention relates to a fastener. The fastener includes: a lower fastening base, in which a pivoting plate is disposed upward on a back end of the lower fastening base and concavely disposed with a limiting groove, an upper fastening plate, disposed on the lower fastening base in a covering manner, in which a back end of the upper fastening plate has at least one pivoting portion pivotally connected to the pivoting plate, a limiting portion, extending backward from the upper fastening plate and penetrating the limiting groove correspondingly, at least one stop block, convexly extending from the limiting portion and located behind the pivoting plate, and a fixing part, disposed on a frond end of the lower fastening base and used for fixing the upper fastening plate to the lower fastening base.
US08425244B2 Connector with a locking sleeve for locking to a socket having a circular band
A locking mechanism for a connector (100) facilitates the interconnect between the connector and an electronic device (200). The connector (100) is formed of a plug (102), a locking sleeve (104) and an o-ring (112). The locking sleeve has a locking pattern (108) that, upon rotation of the locking sleeve, engages and disengages lock between the plug and a socket within the electronic device. Friction from the o-ring (112) on the locking sleeve (104) prevents disengagement of the connector from the electronic device while providing a seal.
US08425241B2 Bus bar system with support means for spacing pole rails
A bus bar system is provided with a base part made of an insulating material, in which the base part exhibits at least two chambers for receiving one pole rail each in which one chamber partition is disposed between two chambers respectively, in which structures are provided which arrange corresponding pole rail for the pole rails disposed on the one side of the chamber partition and for the pole rails disposed on the other side of the chamber partition, wherein these structures are a distance from the chamber partition as formed.
US08425236B2 Tall mezzanine connector
A tall mezzanine connector which connects the substantial middle half of each of a pair of circuit cards positioned normal thereto. The mezzanine connector comprises a and a receptacle that includes wafers having electrical contact means at each end thereof for contacting contacts in the respective circuit cards, the wafers being held in place by an upper base member and a lower base member.
US08425234B2 Joint replica models and methods of using same for testing medical devices
Disclosed herein are joint replica models that are designed to enable simulated use testing by medical device companies, medical device designers, individual inventors, or any other entity interested in the performance of medical devices. These models are unique in possessing a level of complexity that allows them to be substituted for either a live animal, an animal cadaver, or a human cadaver in the testing of these devices. These models are further characterized by a similarity of geometry, individual component physical properties, and component-to-component interfacial properties with the appropriate target tissue and anatomy.
US08425230B2 Two-piece dental abutment system
The present inventions is an abutment for use with a dental implant. The abutment comprises a prosthetic portion adapted to support a prosthesis thereon and an insert. The prosthetic portion has a subgingival end and a supragingival region for protruding beyond gingiva adjacent to the dental implant. The prosthetic portion has a passageway extending therethrough. The passageway includes an enlarged retention groove and non-round section. The insert extends into the passageway and engages the subgingival end of the prosthetic portion. The insert includes flexible retention fingers that, upon insertion into the passageway, initially contract before reaching the enlarged retention groove and then expand outwardly into the enlarged retention groove to hold the insert onto the prosthetic portion. The insert also has a non-round section for mating with the non-round section of the passageway.
US08425226B2 Heat treatment apparatus and method of manufacturing semiconductor device
Provided is a heat treatment apparatus including a treatment chamber housing a silicon substrate, a heater being provided in the treatment chamber and heating the silicon substrate, and an atmosphere adjustment mechanism reducing a concentration of oxygen contained in an atmosphere inside the treatment chamber to less than an oxygen concentration in the air. The atmosphere adjustment mechanism is provided with an oxygen trap, for example.
US08425219B2 Mechanism and system for clamping
A clamping mechanism having: a drive; a shaft connected to the drive; an eccentric hub that is driven to rotate by the shaft; a fixed support structure that supports the eccentric hub such that the eccentric hub can rotate; and a moving support structure that is connected to the eccentric hub such that the moving support structure is driven substantially linearly based on rotational motion of the eccentric hub and serves to clamp an object between the moving support structure and a fixed structure adjacent to the moving support structure. A clamping system is provided having, a single drive; a shaft connected to the drive; and a plurality of clamping mechanisms.
US08425218B2 Networked three-dimensional printing
Three-dimensional fabrication resources are improved by adding networking capabilities to three-dimensional printers and providing a variety of tools for networked use of three-dimensional printers. Web-based servers or the like can provide a single point of access for remote users to manage access to distributed content on one hand, and to manage use of distributed fabrication resources on the other.
US08425216B2 Cycle counting system for injection molding assembly
There is set forth herein a system having an injection molding assembly mold including a stationary section and moveable section, the stationary section having a channel assembly, one or more nozzle and a mold cavity, the mold further having a sensor unit array, the sensor unit array comprising one or more sensor unit. The system can include one or more processing circuit that utilizes an output of the one or more sensor unit for determining a condition prevailing within the injection molding assembly.
US08425214B2 Spraying tool with a switch-off valve
The invention relates to a spraying tool, in particular as part of a mold-spraying device for spraying at least one section of a wall of a mold with working medium. In at least one embodiment, the spraying tool comprises a plurality of spraying elements for dispensing working medium, and at least one working-medium supply line which supplies working medium to the plurality of spraying elements. In accordance with at least one embodiment, at least some of the spraying elements, the spraying nozzles of which point downwards during operation, are equipped with a separate valve unit which is adjacent to the spraying nozzle and the valve element of which is prestressed elastically into a closed position in which it prevents the dispensing of working medium, but can be transferred under the action of a hydraulic and/or pneumatic pressure into an open position in which it permits the dispensing of working medium.
US08425210B2 Two-setting variable-eccentricity vane pump
A variable-eccentricity vane pump having a rotor fitted with blades; an adjusting ring housing the rotor; elastic means for forcing the adjusting ring into a maximum-eccentricity position with respect to the rotor; a first sliding member connected to the adjusting ring and which slides in fluidtight manner inside a first chamber connected hydraulically to a delivery conduit of the pump; and a second sliding member connected to the adjusting ring and which slides in fluidtight manner inside a second chamber connected hydraulically to a delivery conduit of the pump. The first sliding member is connected to the adjusting ring on the opposite side to the elastic means and the second sliding member; and the second chamber is smaller than the first chamber, and has a drain opening formed in a lateral wall on which the second sliding member slides.
US08425207B2 Motor driven air compressor and hydraulic pump module
The present invention provides a motor driven air compressor and hydraulic pump module that makes it possible to adjust the operational speed of the air compressor in accordance with the operational conditions of the air compressor, prevent shock and water from being produced in an air pipe connected to the air compressor by preventing sudden connection/disconnection of torque transmitted from the motor to the air compressor, by using a continuously variable transmission, thereby improving durability of the motor and the air compressor.
US08425204B2 Pump
Pump, for example for pumping lubricating oil in an internal combustion engine, more particularly a multi-stroke vane cell pump, with a rotor and vanes which can slide at least radially in rotor slots and have vane heads that slide along a stroke contour, the stroke contour having a radial outlet that can be closed by a valve device.
US08425203B2 Portable pressure washer system
A portable pressure washer system includes a frame having at least one strap configured such that the frame is supported by a user by way of the at least one strap. A torque generating device is supported by the frame and has an output shaft. A pump is selectively coupled to the output shaft to receive a torque generated by the torque generating device. The pump includes an inlet for connecting to a remote fluid source and an outlet for connecting to a high pressure fluid delivery mechanism. The pump receives a fluid from the remote fluid source by way of the inlet, is driven by the torque generating device to raise a pressure of the fluid to a high pressure fluid, and delivers the high pressure fluid to the high pressure fluid delivery mechanism by way of the outlet.
US08425202B2 Modular, universal and automatic closed-loop pump pressure controller
A universal controller (16) for an electric motorized pump (18) having a mechanical switch (19) for turning on and off electrical power to the pump, and method of operation of same. The controller controls output pressure of the pump based on controlling the speed of the pump (for example by applying voltage over a greater portion of a duty cycle), so as to provide an optimal operating pressure derived from an automatically determined value for the pressure at which the mechanical switch opens and disrupts electrical power to the pump. It is manufactured as a standalone assembly, not attached to a pump. It can be operated so as to automatically seek and determine a switch-opening pressure for the switch (19), at which the pump pressure switch opens and so interrupts electrical power to the motor, and to then choose an operating pressure below the switch-opening pressure.
US08425200B2 Pump controller
The present invention provides a technique using current sensing to control the pressure at constant level without the direct sensing of the pressure. This technique will help to reduce dependency solely on switch or sensor and their non linearity and other associated problems such as the non-repetitive behavior, being affected by EMI etc. The technique includes using a pump controller featuring one or more modules configured to respond to one or more input signals containing information about current provided from a pump; and configured to provide one or more output signals containing information to control the pump to operate at a substantially constant pressure without the direct sensing of pump pressure. The one or more modules control the operation of the pump based at least partly on a table of characteristics related to voltage and current that is calibrated for each pump.
US08425199B2 Paddlewheel apparatus
A paddlewheel apparatus including a paddlewheel axle, spaced apart annular wheel hubs locked in rotation with the axle, and a plurality of elongated paddles supported by the wheel hubs and spaced apart therefrom, the paddles being arranged in a zigzagging pattern around the circumference of the wheel hubs. A method for creating current in a bio-pond raceway using a paddlewheel.
US08425198B2 Air compressor
An air compressor 20, for enabling to restart a fan motor when an inverter trip generates within an inverter control of the fan motor, as well as, to continue supplying of compressed air therefrom, comprises: a compressor main body 1; a compressor motor 2 for driving this compressor main body 1; a fan motor 9b for driving a fan 9a; an inverter for controlling the fan motor; and a controller 10 for controlling driving of the compressor motor 2 and driving of the fan motor 9b. The controller 10 conducts such control that the fan motor 9b is brought into a restart waiting condition while continuing operation of the compressor motor 2 when an inverter trip generates, and thereafter to restart the fan motor 9b.
US08425192B2 Annulus filler
An annulus filler for mounting to a rotor disc of a gas turbine engine bridges the gap between adjacent disc blades. The annulus filler has a lid defining part of an airflow surface for air drawn through the engine; a separate support connectable to the lid and to the rotor disc with an engagement portion of the support extending radially past a substantially adjacent region of the lid; and a retainer configured to interconnect the lid and the support by engaging each engagement portion of the support and adjacent regions of the lid, the retainer defining another part of the airflow surface. The annulus filler can be configured to allow mounting to the rotor disc, where the support is connected to the rotor disc without the lid, and then the lid is mounted to the support such that each engagement portion remains visible from the lid's radially outermost side.
US08425190B2 Pressure relief device
A pressure relief device includes a main body and at least two air control units. The main body has at least one passage therein and two outlets formed at upper and lower ends of the passage. A lid is pivotally connected to each of the outlets. The two air control units are each disposed in the passage close to the lid. An air control device drives the air control units to open/close the lid which is adapted to open/close the passage.
US08425189B2 Rotor mounting
A rotor mounting on one end of a shaft, particularly a shaft end of a centrifugal pump unit, in which an adjusting surface and at least one contact surface are constructed on the shaft end, and in which a rotor hub is provided at least on the end facing the shaft with a central bore having an internal thread. The rotor hub is attached to the shaft end by a screw connection. The shaft has a central bore (16) having an internal thread (17) at least on the end facing the rotor hub (12); a threaded pin (18) constructed as a separate component is disposed in both central bores (13, 16) in a connecting, torque-transmitting and force-transmitting manner, and the rotor is aligned on the shaft solely by the adjusting surfaces (20) and contact surfaces (21).
US08425184B2 Turbine shroud ring with rotation proofing recess
A turbine shroud ring sector for a turbomachine supported at the upstream end by a downstream support of a turbine casing with circular sliding including a first stop able to collaborate with a second stop borne by an element of the turbomachine adjacent to the shroud ring in order to immobilize the shroud ring circularly is disclosed. The sector includes, on an end facing the element, a recess able to allow the second stop to pass to come into contact with the first stop. The recess is cut substantially in the form of a rectangle having, at the bottom of the recess, corners that are rounded in a circular arc of radius r. The bottom of the recess has a convex shape tangential to the circular arcs of the rounded corners and with a curvature that evolves between a radius of curvature r where it meets the rounded corners and a radius of R, greater than the radius r, at a point situated between the two rounded corners.
US08425183B2 Triforial tip cavity airfoil
A turbine blade includes an airfoil having first and second tip ribs extending along the opposite pressure and suction sides thereof. The tip ribs are spaced apart between the leading and trailing edges of the airfoil to include a trifurcate tip baffle defining a triforial tip cavity.
US08425181B2 Axial-flow turbine with flow extraction means
The axial-flow turbine includes an extraction chamber 15 disposed on the outer circumference of a turbine blade chamber 12 and an extraction opening 16. An outer diaphragm 8 forming the downstream-side wall surface of the extraction chamber 15 is provided with a projection 21 formed more radially inwardly than the downstream-side edge on the outer circumference of an adjacent bucket 2 on the upstream side of the extraction opening 16 to form the downstream-side wall surface of the extraction opening 16. The projection 21 forms an upstream-side wall surface 18 of the outer diaphragm 8 for leading a part of the working fluid to the extraction chamber 15, and an inner wall surface 19 of the outer diaphragm 8 for leading the remaining working fluid to a bucket 11 on the downstream side of the extraction opening 16.
US08425180B2 Systems and apparatus relating to steam turbine operation
A steam turbine power plant that includes a first steam turbine, the steam turbine power plant including: a thrust piston operably connected to the first steam turbine via a shaft; and means for applying a supply of pressurized steam against the thrust piston such that the thrust piston applies a desired thrust force to the shaft. The desired thrust force may comprise a thrust force that partially balances a thrust force the first steam turbine applies to the shaft during operation.
US08425171B2 Pipe handling system and method
A racking assembly for receiving and storing at least one pipe. The racking assembly comprises a set back assembly including a selectively rotatable member having a plurality of radial slots sized for receiving a portion of the pipe(s) in sliding engagement, and a base for supporting the pipe(s). The base is coupled to the selectively rotatable member so as to permit mutual rotation. A barrier is located about a peripheral edge of the base, such that the setback assembly rotates relative to the barrier. The barrier is arranged to prevent the pipe(s) from moving radially from the base. The barrier has a gap sized to permit selective lateral movement of the pipe(s). Mutual rotation of the selectively rotatable member and the base permit alignment of the gap and a selected slot of the selectively rotatable member, and thus permits the pipe stands to be moved laterally into the setback assembly.
US08425170B2 Bonded adhesion of wire-shaped individual elements by means of a two-layer acrylate resin-based system
The present invention relates to a method for the bonded adhesion, or connection, of a plurality of wire-shaped individual elements into an arrangement, particularly into a wire band, wherein the adjacent individual elements have predetermined breaking points allowing for the mechanical removal of the individual elements. The bonded adhesion is brought about according to the invention utilizing a two-layer system on the basis of acrylate resins consisting of an inner coating (A) and of an outer coating (B), wherein the inner coating (A) has a lower hardness, than the outer coating. In a further aspect the invention also comprises arranging a plurality of wire-shaped individual elements through such a bonded connection, particularly a wire band.
US08425164B2 Method and device for balancing a tool coupling
For balancing a tool coupling, the compensating measures (removal of material, use of other material) are carried out in two planes an axial distance apart. Tool couplings are provided with recesses for imbalance compensation in two planes an axial distance apart.
US08425162B2 Servo drill spindle
A servo drill spindle includes a spindle body, an air motor slidably carried by the spindle body, a spindle extension drivingly engaged by the air motor, a cutting tool drivingly engaged by the spindle extension and a servo motor engaging the air motor and operable to advance the air motor along the spindle body.
US08425161B2 Cutting tool with detachable insert, head member and tool body of the same
In a head member (30) for a cutting tool with detachable insert (70) including a head member body (31) formed with an insert attachment seat (36) to which a cutting insert (50) having cutting blades (52) is detachably attached, and constituting the cutting tool with detachable insert (70) by being mounted to a tip portion of a holder (10), a side surface (31A) of the head member body (31) is formed with a recess (44) which has a continuous inner wall surface therearound and a bottom surface connected to the inner wall surface over its whole periphery and which is recessed from the side surface (31A) without passing though the head member body (31). According to this head member (30), generation of chatter vibration can be suppressed even if the amount of protrusion is increased, and the cutting heat of a cutting insert can be efficiently radiated.
US08425152B1 Arched culvert and method of manufacture
An arched culvert includes a first foundation having a top surface with a plurality of first reinforcing members upwardly projecting therefrom. A first arch includes a body having an arched interior surface and an opposing exterior surface extending between a first end and an opposing second end, the first end of the first arch being positioned on the top surface of the first foundation adjacent to the first reinforcing members. A first opening extends through the first arch between the interior surface and the exterior surface at the first end thereof. A first locking wall is formed on the top surface of the first foundation so that at least a portion of the first reinforcing members are embedded within the first locking wall and the first locking wall extends along the exterior surface of the first arch and into the first opening of the first arch.
US08425145B2 Apparatus and method for repairing an existing spill containment manhole
An apparatus for repairing an existing spill containment manhole operably associated with an underground fuel storage tank. The apparatus includes a containment vessel for containing fuel spilled during filling of the underground fuel storage tank. A major portion of the containment vessel is adapted to be inserted into an existing spill containment manhole. The containment vessel includes at least one wall that surrounds an existing pipe section operably associated with the underground fuel storage tank when the containment vessel is installed. The at least one wall has an inner surface and an outer surface. Preferably, the containment vessel includes an upper annular flange that extends over and surrounds a portion of an existing cover rim of an existing spill containment manhole thereby isolating an upper portion of the containment vessel from an upper portion on the existing spill containment manhole when the containment vessel is installed. Optionally, a replacement cover is provided to replace an existing cover of the existing spill containment manhole. The replacement cover may include at least one sealing member that engages the inner surface of the at least one wall of the containment vessel when installed. The containment vessel may also include a drain assembly for selectively draining fuel collected in the containment vessel back into the underground fuel storage tank. Preferably, the containment vessel includes a compact seal assembly for providing a fluid tight seal around an existing fill port.
US08425142B2 Connecting arrangement and articulated shaft comprising same
A connecting arrangement for a rotationally fixed connection of components in the drive train of a motor vehicle, comprising a shaft journal and a hub of an articulation, which has a central opening for receiving the shaft journal, wherein the shaft journal can be axially fixed in the hub, for example by a retaining ring. The invention further relates to an articulated shaft comprising such a connecting arrangement.
US08425140B2 Fastening device and object having the same
A fastening device is adapted for fastening a first article to a second article, and includes a first hook, two positioning plates, and a second hook. The first hook is disposed on the first article. The positioning plates are disposed on the first article, and flank the first hook. Each of the positioning plates includes a positioning guide tack. The positioning guide track includes an upright slot portion, a curved guiding slot portion, and a stop shoulder. The curved guiding slot portion is located at a side of the upright slot portion distal from the first hook. The second hook includes an upright plate body disposed pivotally on the second article, a hook body engaging removably the first hook, and two guiding rods flanking the hook body. Each of the guiding rods includes a guiding stub engaging the stop shoulder.
US08425139B2 Sheet holder and edge pattern making apparatus incorporating the same
A sheet holder for holding a sheet of paper and exposing an edge of the sheet, has a press for holding the paper sheet and exposing the edge, and a lever for operating the press. The lever is movable between a released position for placing of the edge of the paper sheet in the press and a holding position for operating the press. There is also an abutment for abutment by the edge of the paper sheet to position the edge relative to the press while the lever is in the released position. The abutment is associated with the lever for moving away from the edge of the paper sheet when the lever moves towards the holding position, thereby exposing the edge of the paper sheet.
US08425136B2 Apparatus for treating a stain in clothing
A package for treating stained fabric. The package can have a backing layer having a second side and a pouch layer joined thereto to form a pouch. A fluid pervious contact substrate can be joined to a first side of the backing layer. The pouch can contain a stain treatment fluid. The package can have a first position in which first and second planar regions of the backing layer are substantially in plane with one another. The package can have a second position in which first planar region and second planar region are in a substantially angularly facing relationship. In the second position the pouch can be in fluid communication with the contact substrate. The stain treatment fluid can include a surfactant.
US08425133B2 Discrete-amount fluid-dispensing system for a personal care device
The fluid-dispensing system is used in a personal care appliance, such as a power toothbrush. The dispensing system includes a strip of discrete, fluid-containing packets, a compressible sealing member and a hollow needle for puncturing the packets, the hollow needle being connected to a workpiece such as a brushhead via a connecting line. An actuation assembly includes a piston which moves successive packets against the sealing member, initially sealing the packet thereto. Further pressure results in compression of the sealing member and puncturing of the packet by the needle, with fluid being forced by piston pressure from the packet into the hollow needle and then to the connecting line for delivery to the workpiece.
US08425124B2 Vehicle bearing device
In a vehicle bearing device hub spindle, annular first to third grinding undercut portions, each being a recess in sectional view, are formed in the same shape, through turning, at a large-rib-surface-side end portion of an inner raceway surface, a large-diameter-portion-side end portion of the inner raceway surface, and a large-diameter-portion-side end portion of an outer peripheral surface of an intermediate-diameter portion.
US08425121B2 Rolling bearing with spherical separators
This ball (2) rolling bearing (1) comprises an outer ring (7) and an inner ring (8) between which the balls (2) roll around an axis of rolling (X1), spherical separators (3) for the balls (2), and a raceway (14) of revolution about the axis of rolling (X1) and along which the said spherical separators (3) roll. The raceway is a channel section (14) formed in an element (13; 23) secured to or forming part of one of the said rings (7; 8) and having a substantially semi-cyclic cross section of a diameter suited to that of the said spherical separators (3) so as to accommodate the said separators resting in positions in which they are retained laterally and free of contact with the other of the said rings (8; 7). A rolling bearing such as this is particularly well suited to use without lubrication, particularly in the space industry.
US08425119B2 Gas bearings
A rotary gas bearing is described that comprises a first part rotatable relative to a second part. The first part comprises a support member and a first portion and a second portion attached to the support member. The first portion comprises a first bearing surface and the second portion comprising a second bearing surface. Both the first portion and the second portion are attached to the support member by screw thread connections. The second part may comprise complimentary bearing surfaces. Epoxy may be used to fix the first and/or second portions to the support member. A method of determining the bearing working gap by measuring gas flow through the bearing is also described.
US08425111B2 Bridge intelligent cable system with built-in fiber grating sensor
A bridge intelligent cable system with a built-in fiber grating sensor is provided, which is applied in a cable bearing structure such as a cable-stayed bridge, a suspension bridge, and an arch bridge. The system includes an anchor cup, a wire dividing plate, a connecting cylinder, a fiber grating sensor, and a cable body, in which the fiber grating sensor includes a fiber grating strain sensor and a fiber grating temperature sensor, tail fibers of the fiber grating strain sensor and the fiber grating temperature sensor are led out, the packaged fiber grating strain sensor is fixedly connected to an outer-layer steel wire of the connecting cylinder, the packaged fiber grating temperature sensor is suspended on the steel wire of the connecting cylinder, holes are punched in the wire dividing plate, and a preserved steel pipe is buried in advance in the connecting cylinder and the anchor cup.
US08425109B2 Ice fishing hole maintenance system
A device and method prevents freeze over of a fishing hole cut through a layer of ice overlying a body of water. The device has a housing; a motor; at least one water inlet in the housing; at least one water outlet in the housing; and at least one water-moving element driven by the motor and moving water out of the at least one water outlet. The device may spin within the hole and stir water to prevent too rapid ice buildup.
US08425108B2 Mixing paddle for ice cream machine
A mixing paddle for use in a conventional ice cream maker includes two vertical arms that have outer contact edges that exceed the inner diameter of the freezer bowl in which they are positioned during use. This enables the contact edges to effectively scrape ice cream ingredients from the inner wall of the bowl during use and direct the ingredients toward the center of the bowl. The mixing paddle also comprises two cross-members that have pin-wheel style shapes that move ice cream ingredients vertically during use. The combined effect of the vertical arms and the cross-members optimally and uniformly mixes the ice cream ingredients during use and ensures efficient cooling.
US08425102B2 Ultrathin lighting element
An ultra thin lighting element including at least one light source. A lightguide element includes one lightguide layer comprising a plurality of discrete fine optic surface relief structures on at least one portion of at least one surface. Each surface relief structure includes basic structural features on the order of about 10 microns or less in height, and on the order of about 10 microns or less in each lateral dimension. The number, arrangement and size of each surface relief structure and height and lateral dimensions of the structural features of the surface relief structures being varied to provide a desired degree of outcoupling modulation of light incoupled into the light guide element.
US08425100B2 Luminous button device and electronic apparatus
A luminous button device includes: a button base which is integrally formed of a transmissive material; and a button cap which is integrally formed of a non-transmissive material and is fitted to the button base, wherein the button cap includes a cap body; a pair of arm portions which extends from the rear surface of the cap body with a gap interposed therebetween; and a pair of locking claws which is formed at the front ends of the pair of arm portions, and wherein the button base includes a movable portion which is movable in the direction of pressing a switch disposed on the rear surface side of the button base in accordance with a pressing force from the front button surface side; and a support portion which supports the movable portion so as to be movable in the direction.
US08425099B2 Ventilating unit with moisture absorber, especially for a motor vehicle headlight
A ventilating unit with moisture absorber consists of an essentially vertically oriented bushing (1), provided with shoulders for engaging in an opening made in the bottom part (4) of the headlight cover and a bottom with an outlet opening, while on the bottom of the bushing there is arranged a filtering mechanism (2) on which is fitted a ventilating insert (3) with moisture absorber, whose outer peripheral walls are in close contact with the inner peripheral wall of the bushing (1). Advantageously, a paper filter is the filtering mechanism (2), and magnesium chloride hexahydrate is the moisture absorber, while a sealing element (5) is placed between at least one shoulder of the bushing (1) and the bottom part (4) of the headlight cover.
US08425096B2 Signal light of mirror type
The signal light of mirror type consists of a light source (1), a primary optical component (2), a secondary optical component (3), a tertiary optical component (4), one or more internal glasses (5), a cover glass (6) and an optical filter (7), characterized in that the light put out by the light source (1) is focused by the primary optical component (2) on the secondary optical component (3), and scattering elements, which are on the primary optical component (2) or on the secondary optical component (3) or on the primary optical component (2) and the secondary optical component (3), after passing through the optical filter (7) are projected onto the tertiary optical component (4), while the tertiary optical component (4) is formed by one or more smooth surfaces of a mirror type, and the image of the scattering elements is further distributed by the tertiary optical component (4) and passes through the one or more internal glasses (5) and the cover glass (6).
US08425091B2 Divided LED lamp
A divided LED lamp includes an LED assembly, a casing assembly, LED electronics, power and signal cables, a control panel including a display screen and operation buttons, and a bracket for mounting the lamp. The casing assembly includes a first casing member and a second casing member. At least one cable tube is formed between the first casing member and the second casing member. The power and signal cables that connect the LED assembly received in the first casing member and the LED electronics received in the second casing member are received through the cable tube. This arrangement allows the LED assembly and the LED electronics to be received in individual and independent casing members and are associated with respective individual heat dissipation fins or heat radiators, so as to realize high efficiency of heat dissipation, stabilized operation, and extended lifespan.
US08425090B2 Reflector cup and LED lamp comprising the same
The present invention provides a reflector cup for a lamp, including a cup body, a cup top having an aperture through which a light source is inserted into the reflector cup, and a cup bottom provided with an opening for outputting lights from the light source. The cup body is provided with a plurality of recesses or protrusions that have a curvature different from that of a surface profile of the reflector cup. In one preferred embodiment, the cup body is provided with a plurality of grid veins arranged in a matrix, in each of the grid veins is formed a protruded or recessed curved surface. The curved surface may be spherical, cylindrical, conical or the like. The invention also provides a LED reflector lamp comprising the reflector cup.
US08425089B2 Lighted stanchion cover
A lighted stanchion cover for use with a stanchion for the purpose of providing illumination in dark conditions. The cover assembly comprising an elongated tubular body and a lighting assembly. The lighting assembly further comprising a light source and a power source. The elongated tubular body has an open end, a closed end, and an interior cavity. The interior cavity of the tubular body is dimensioned to receive a stanchion through its open end. A lighting assembly is disposed within the tubular body in a manner that does not interfere with the reception of the stanchion into the interior cavity of the tubular body. The lighted stanchion cover can be adapted to receive power from an integrated or external source. The tubular body can be customized to display messages or advertisements that can be easily seen in dark conditions.
US08425087B2 Luminous flux control member and optical apparatus having the same
A luminous flux control member can stabilize an optical performance, make manufacturing easy and improve efficiency of use of light at the same time. A reflection surface (15) is formed in a surface shape, so that an extreme end section of the reflection surface (15) that is the most distant from an emission area (5) is positioned further inward in the radial direction than a base end section that is the closest to the emission area (5), and the reflection surface (15) intersects once a virtual surface that is inclined with respect to an optical axis connecting between the extreme end section and the base end section. The surface shape suppresses an offset of a light distribution of light emitted from the emission area (5) from a designed light distribution due to an offset between an optical axis and the center axis of light emitted from a light source.
US08425086B2 Light emitting diode lamp structure
The present invention is a light emitting diode lamp structure, which comprises a heat dissipating plane, a light emitting housing and a base. The light emitting housing further comprises a casing and a first hollow region. The heat dissipating plane is partly covered by the casing and the rest of the heat dissipating plane is shown in the first hollow region. The part of the heat dissipating plane covered by the casing further includes a plurality of LEDs. The base is mounted with the light emitting housing and electrically engaged with the LEDs.
关于PatentHub
关于我们 加入我们 联系我们 帮助中心
PatentHub产品
专利百科 商标查询 专利交易 大学排行榜 行业专题库
API接口 排行榜 专利资讯 最新中国发明专利 最新美国发明专利
PatentHub联系方式
QQ：3307693423 QQ：3236401158