Document Document Title
US08410568B2 Integrated photodiode for semiconductor substrates
A substrate section that is at least partially fabricated to include contact elements and materials. The substrate section includes doped regions that have a heavily doped N-type region and a heavily doped P-type region adjacent to one another. An exterior surface of the substrate has a topography that includes a light-transparent region in which light, from a light source, is able to reach a surface of the substrate. An application of light onto the light transparent region is sufficient to cause a voltage potential to form across a junction of the heavily doped regions. The substrate section may further comprise one or more electrical contacts, positioned on the substrate section to conduct current, resulting from the voltage potential created with application of light onto the light transparent region, to a circuit on the semiconductor substrate.
US08410563B2 Apparatuses for generating electrical energy
Electrical energy generation apparatuses, in which a solar battery device and a piezoelectric device are combined in a single body by using a plurality of nano wires formed of a semiconductor material having piezoelectric properties.
US08410557B2 Semiconductor device and method of manufacturing the same
A P type drift layer is formed in an N type epitaxial layer from under a drain layer to under an N type body layer under a source layer through under an element isolation insulation film. This P type drift layer is shallower immediately under the drain layer than under the element isolation insulation film, and gradually shallows from under the element isolation insulation film to the N type body layer to be in contact with the bottom of the N type body layer. Since the P type drift layer is thus diffused in a wide region, a wide current path is formed from the N type body layer to the drain layer, and the current drive ability is enhanced and the drain breakdown voltage is also increased.
US08410553B2 Semiconductor structure including high voltage device
A high voltage device includes a substrate with a device region defined thereon. A gate stack is disposed on the substrate in the device region. A channel region is located in the substrate beneath the gate stack, while a first diffusion region is located in the substrate on a first side of the gate stack. A first isolation structure in the substrate, located on the first side of the gate stack, separates the channel and the first diffusion region. The high voltage device also includes a first drift region in the substrate coupling the channel to the first diffusion region, wherein the first drift region comprises a non-uniform depth profile conforming to a profile of the first isolation structure.
US08410549B2 Structure and fabrication of field-effect transistor using empty well in combination with source/drain extensions or/and halo pocket
Insulated-gate field-effect transistors (“IGFETs”), both symmetric and asymmetric, suitable for a semiconductor fabrication platform that provides IGFETs for analog and digital applications, including mixed-signal applications, utilize empty-well regions in achieving high performance. A relatively small amount of semiconductor well dopant is near the top of each empty well. Each IGFET (100, 102, 112, 114, 124, or 126) has a pair of source/drain zones laterally separated by a channel zone of body material of the empty well (180, 182, 192, 194, 204, or 206). A gate electrode overlies a gate dielectric layer above the channel zone. Each source/drain zone (240, 242, 280, 282, 520, 522, 550, 552, 720, 722, 752, or 752) has a main portion (240M, 242M, 280M, 282M, 520M, 522M, 550M, 552M, 720M, 722M, 752M, or 752M) and a more lightly doped lateral extension (240E, 242E, 280E, 282E, 520E, 522E, 550E, 552E, 720E, 722E, 752E, or 752E). Alternatively or additionally, a more heavily doped pocket portion (250 or 290) of the body material extends along one of the source/drain zones. When present, the pocket portion typically causes the IGFET to be an asymmetric device.
US08410548B2 Method of fabricating a deep trench insulated gate bipolar transistor
In one embodiment, a method comprises forming an epitaxial layer over a substrate of an opposite conductivity type, the epitaxial layer being separated by a buffer layer having a doping concentration that is substantially constant in a vertical direction down to the buffer layer. A pair of spaced-apart trenches is formed in the epitaxial layer from a top surface of the epitaxial layer down at least into the buffer layer. A dielectric material is formed in the trenches over the first and second sidewall portions. Source/collector and body regions of are formed at the top of the epitaxial layer, the body region separating the source/collector region of the pillar from a drift region of the epitaxial layer that extends from the body region to the buffer layer. An insulated gate member is then formed in each of the trenches adjacent to and insulated from the body region.
US08410545B2 Semiconductor memory and method of manufacturing the same
A semiconductor memory includes a semiconductor substrate, a buried insulating film formed on a part of an upper surface of the semiconductor substrate, and a semiconductor layer formed on another part of the upper surface of the semiconductor substrate. Each of the memory cell transistors comprises a first-conductivity-type source region, a first-conductivity-type drain region, and a first-conductivity-type channel region arranged in the semiconductor layer in the column direction, and a gate portion formed on a side surface of the channel region in the row direction.
US08410543B2 Semiconductor storage device and manufacturing method thereof
In a non-volatile memory in which writing/erasing is performed by changing a total charge amount by injecting electrons and holes into a silicon nitride film serving as a charge accumulation layer, in order to realize a high efficiency of a hole injection from a gate electrode, the gate electrode of a memory cell comprises a laminated structure made of a plurality of polysilicon films with different impurity concentrations, for example, a two-layered structure comprising a p-type polysilicon film with a low impurity concentration and a p+-type polysilicon film with a high impurity concentration deposited thereon.
US08410540B2 Non-volatile memory device including a stacked structure and voltage application portion
According to one embodiment, a non-volatile memory device includes a stacked structure including a memory portion and an electrode having a surface facing the memory portion; and a voltage application portion to apply a voltage to the memory portion to change resistance. The surface includes first and second regions. The first region contains a first nonmetallic element and at least one element of a metallic element, Si, Ga, and As. The second region contains a second nonmetallic element and the at least one element. The second region has a content ratio of the second nonmetallic element higher than that in the first region. A difference in electronegativity between the second nonmetallic element and the at least one element is greater than that between the first nonmetallic element and the at least one element. At least one of the first and second regions has an anisotropic shape.
US08410531B2 Thin film transistor having Schottky barrier
A thin film transistor having Schottky barrier includes a substrate, a first gate conductive layer formed on the substrate, a first semiconductor layer having a first conductive type formed on the first gate conductive layer, a source conductive layer and a drain conductive layer electrically isolated from each other and positioned on the first semiconductor layer, a second semiconductor layer having a second conductive type formed on the source conductive layer and the drain conductive layer, and a second gate conductive layer formed on the second semiconductor layer. The first conductive type is complementary to the second conductive type.
US08410529B2 Magnetic random access memory and method of fabricating the same
According to one embodiment, a semiconductor device, includes a magneto resistive element including a first magnetic layer, a first interface magnetic layer, a nonmagnetic layer, a second interface magnetic layer and a second magnetic layer as a stacked structure in order; and a metal layer including first metal atoms, second metal atoms and boron atoms, the metal layer being provided at least one region selected from under the first magnetic, between the first magnetic layer and the first interface magnetic layer, between the second interface magnetic layer and the second magnetic layer, and upper the second magnetic layer.
US08410527B2 Electrical fuse device based on a phase-change memory element and corresponding programming method
A fuse device has a fuse element provided with a first terminal and a second terminal and an electrically breakable region, which is arranged between the first terminal and the second terminal and is configured to undergo breaking as a result of the supply of a programming electrical quantity, thus electrically separating the first terminal from the second terminal. The electrically breakable region is of a phase-change material, in particular a chalcogenic material, for example GST.
US08410523B2 Misfit dislocation forming interfacial self-assembly for growth of highly-mismatched III-SB alloys
Exemplary embodiments provide high-quality layered semiconductor devices and methods for their fabrication. The high-quality layered semiconductor device can be formed in planar with low defect densities and with strain relieved through a plurality of arrays of misfit dislocations formed at the interface of highly lattice-mismatched layers of the device. The high-quality layered semiconductor device can be formed using various materials systems and can be incorporated into various opto-electronic and electronic devices. In an exemplary embodiment, an emitter device can include monolithic quantum well (QW) lasers directly disposed on a SOI or silicon substrate for waveguide coupled integration. In another exemplary embodiment, a superlattice (SL) photodetector and its focal plane array can include a III-Sb active region formed over a large GaAs substrate using SLS technologies.
US08410520B2 Rugged registered jack connection
Systems and methods are disclosed that include a first registered jack and a junction coupled to the first registered jack. These systems and methods also include a first source unit connected to the junction and a first layer encasing at least part of the first registered jack, the junction, and the first source unit. In addition, these systems and methods include an o-ring preventing surrounding the first layer and a housing encasing the first layer and the o-ring.
US08410511B2 Methods for high temperature processing of epitaxial chips
High temperature semiconducting materials in a freestanding epitaxial chip enables the use of high temperature interconnect and bonding materials. Process materials can be used which cure, fire, braze, or melt at temperatures greater than 400 degrees C. These include, but are not limited to, brazing alloys, laser welding, high-temperature ceramics and glasses. High temperature interconnect and bonding materials can additionally exhibit an index of refraction intermediate to that of the freestanding epitaxial chip and its surrounding matrix. High index, low melting point glasses provide a hermetic seal of the semiconductor device and also index match the freestanding epitaxial chip thereby increasing extraction efficiency. In this manner, a variety of organic free semiconducting devices, such as solid-sate lighting sources, can be created which exhibit superior life, efficiency, and environmental stability.
US08410510B2 Semiconductor light emitting device and method for fabricating the same
A semiconductor light emitting device, which includes: a first conductivity-type semiconductor layer; a second conductivity-type semiconductor layer; a semiconductor light emitting portion having a light emitting layer which is disposed between the first conductivity-type semiconductor layer and the second conductivity-type semiconductor layer; a first conductivity-type semiconductor side electrode connected to the first conductivity-type semiconductor layer; and a second conductivity-type semiconductor side electrode connected to the second conductivity-type semiconductor layer, wherein the second conductivity-type semiconductor side electrode is disposed separated from an insulator film covering the semiconductor light emitting portion by a separation area.
US08410506B2 High efficiency light emitting diode
Provided is a high-efficiency light emitting diode (LED) that includes: a support substrate; a semiconductor stack positioned on the support substrate, the semiconductor stack including a p-type compound semiconductor layer, an active layer, and an n-type compound semiconductor layer; a first electrode positioned between the support substrate and the semiconductor stack and in ohmic contact with the semiconductor stack; a first bonding pad positioned on a portion of the first electrode that is exposed outside of the semiconductor stack; and a second electrode positioned on the semiconductor stack. Protrusions are formed on exposed surfaces of the semiconductor stack. In addition, the second electrode may be positioned between the first electrode and the support substrate and contacted with the n-type compound semiconductor layer through openings of the semiconductor stack.
US08410504B2 LED module
The present invention relates to a LED module which converts pump light from a LED chip (120) to light at another wavelength, which is emitted from the module. The conversion takes place in a portion of a luminescent material (124). The color purity of the LED module is enhanced by reducing any leakage of pump light using a reflector in combination with an absorber. In one embodiment, the absorber is integrated as one or several thin absorbing layers between the layers of a multi-layer reflection filter (126); this may yield an even higher reduction of pump light leakage from the module.
US08410503B2 Light emitting devices
A new light emitting device is disclosed, including a polarizing surface layer, a light emitting layer which emits light at a wavelength, and a light transformation layer disposed between the light emitting layer and the reflective layer, wherein the light emitting layer is disposed between the reflective layer and the polarizing surface layer, and an optical thickness between the light emitting layer and the reflective layer is less than a value of five times of a quarter of the wavelength.
US08410498B2 Semiconductor light emitting device and method for manufacturing the same
A semiconductor light emitting device includes a first cladding layer, a second cladding layer, and an active layer formed between the first and second cladding layers. A diffusion control layer includes an intermediate layer and a first transparent conductive layer provided on the second cladding layer in this order. The semiconductor light emitting device further includes a second transparent conductive layer having an impurity in a concentration lower than an impurity concentration of the diffusion control layer, and a third transparent conductive layer having an impurity in a concentration higher than the impurity concentration of the second transparent conductive layer. The boundary between the intermediate layer and the first transparent conductive layer is a lattice mismatch interface.
US08410497B2 Semiconductor light emitting device
There is provided a semiconductor light emitting device that can easily dissipate heat, improve current spreading efficiency, and reduce defects by blocking dislocations occurring when a semiconductor layer is grown to thereby increase reliability. A semiconductor light emitting device including a substrate, a light emitting structure having an n-type semiconductor layer, an active layer, and a p-type semiconductor layer sequentially laminated, and an n-type electrode and a p-type electrode formed on the n-type semiconductor layer and the p-type semiconductor layer, respectively, according to an aspect of the invention may include: a metal layer formed in the n-type semiconductor layer and contacting the n-type electrode.
US08410492B2 Light-emitting element, light-emitting device and an electronic device, which include two layers including same light-emitting organic compound
The present invention provides a light-emitting element including an electron-transporting layer and a hole-transporting layer between a first electrode and a second electrode; and a first layer and a second layer between the electron-transporting layer and the hole-transporting layer, wherein the first layer includes a first organic compound and an organic compound having a hole-transporting property, the second layer includes a second organic compound and an organic compound having an electron-transporting property, the first layer is formed in contact with the first electrode side of the second layer, the first organic compound and the second organic compound are the same compound, and a voltage is applied to the first electrode and the second electrode, so that both of the first organic compound and the second organic compound emit light.
US08410488B2 Micropipe-free silicon carbide and related method of manufacture
Micropipe-free, single crystal, silicon carbide (SiC) and related methods of manufacture are disclosed. The SiC is grown by placing a source material and seed material on a seed holder in a reaction crucible of the sublimation system, wherein constituent components of the sublimation system including the source material, reaction crucible, and seed holder are substantially free from unintentional impurities. By controlling growth temperature, growth pressure, SiC sublimation flux and composition, and a temperature gradient between the source material and the seed material or the SiC crystal growing on the seed material during the PVT process, micropipe-inducing process instabilities are eliminated and micropipe-free SiC crystal is grown on the seed material.
US08410479B2 Transistors, electronic devices including a transistor and methods of manufacturing the same
Transistors, electronic devices including a transistor and methods of manufacturing the same are provided, the transistor includes an oxide semiconductor layer (as a channel layer) having compositions that vary in one direction. The channel layer may be an oxide layer including a first element, a second element, and Zn, which are metal elements. The amount of at least one of the first element, the second element, and Zn may change in a deposition direction of the channel layer. The first element may be any one of hafnium (Hf), yttrium (Y), tantalum (Ta), zirconium (Zr), gallium (Ga), aluminum (Al) or combinations thereof. The second element may be indium (In). The channel layer may have a multi-layered structure including at least two layers with different compositions.
US08410469B2 Chalcogenide nanoionic-based radio frequency switch
A nonvolatile nanoionic switch is disclosed. A thin layer of chalcogenide glass engages a substrate and a metal selected from the group of silver and copper photo-dissolved in the chalcogenide glass. A first oxidizable electrode and a second inert electrode engage the chalcogenide glass and are spaced apart from each other forming a gap therebetween. A direct current voltage source is applied with positive polarity applied to the oxidizable electrode and negative polarity applied to the inert electrode which electrodeposits silver or copper across the gap closing the switch. Reversing the polarity of the switch dissolves the electrodeposited metal and returns it to the oxidizable electrode. A capacitor arrangement may be formed with the same structure and process.
US08410468B2 Hollow GST structure with dielectric fill
A memory cell structure, including a substrate having a via therein bound at first and second ends thereof by electrodes. The via is coated on side surfaces thereof with GST material defining a core that is hollow or at least partially filled with material, e.g., germanium or dielectric material. One or more of such memory cell structures may be integrated in a phase change memory device. The memory cell structure can be fabricated in a substrate containing a via closed at one end thereof with a bottom electrode, by conformally coating GST material on sidewall surface of the via and surface of the bottom electrode enclosing the via, to form an open core volume bounded by the GST material, optionally at least partially filling the open core volume with germanium or dielectric material, annealing the GST material film, and forming a top electrode at an upper portion of the via.
US08410467B2 Nonvolatile memory device and method of manufacturing the same
According to one embodiment, a nonvolatile memory device includes a first wire, a second wire and a nonvolatile memory cell. The first wire is formed to extend in a first direction, and the second wire is formed at height different from height of the first wire and to extend in a second direction. The nonvolatile memory cell is arranged to be held between the first wire and the second wire in a poison where the first wire and the second wire cross. The nonvolatile memory cell includes a nonvolatile storage layer and a current limiting resistance layer connected in series to the nonvolatile storage layer and having resistance of 1 kilo-ohm to 1 mega-ohm.
US08410466B2 Non-contact component inspection system
A system and method for measuring the physical characteristics of a component where the system includes an electromagnetic radiation source defining a source optical path, the electromagnetic radiation source being operable to cause electromagnetic radiation to propagate along the source optical path, a sensing device defining a sensor optical path, a system support structure, a base structure, an electromagnetic radiation source mounting structure and a sensing device mounting structure, a positioning device including a positioning device stage, wherein the positioning device stage is movably disposed and a retention mount disposed on the positioning device stage, the retention mount being disposed within the sensor optical path such that when a component is retained within the retention mount, the component blocks at least a portion of the electromagnetic radiation to generate a silhouette, wherein the sensing device generates data responsive to the silhouette.
US08410465B2 Apparatus and method for inspecting defects of a circuit pattern formed on a substrate using a laser and a non-contact capacitor sensor
An apparatus for inspecting defects in a circuit pattern is described. The apparatus includes at least one laser unit for radiating a laser beam onto a first end of a circuit pattern formed on a substrate. The apparatus also includes a capacitor sensor disposed opposite a second end of the circuit pattern, which is connected to the first end of the circuit pattern through a via hole, in a non-contact manner. The apparatus also includes a voltage source connected to the capacitor sensor and configured to apply a voltage. The apparatus also includes a measurement unit connected to the capacitor sensor and configured to detect variation in impedance generated in the capacitor sensor.
US08410461B2 Methods and apparel for attenuating electromagnetic fields emanating from a person in a human adversarial situation
A method comprises attenuating, while involved in a human adversarial situation, one's own emanated electromagnetic field at frequencies less than about 1 gigahertz by wearing one or more articles of apparel that include an electromagnetically shielding fabric. Another method comprises (i) providing to the user the one or more articles of apparel that include an electromagnetically shielding fabric, and (ii) instructing the user to wear at least one of the articles of apparel while involved in the human adversarial situation. The shielding fabric comprises a substantially continuous system of conductive fibers combined with a non-conductive fabric and attenuates the emanated electromagnetic field at frequencies less than about 1 gigahertz. Attenuating the emanated electromagnetic field at frequencies less than about 1 gigahertz decreases the likelihood of that emanated field affecting progress or an outcome of the human adversarial situation.
US08410459B2 Ion implantation device and a method of semiconductor manufacturing by the implantation of boron hydride cluster ions
An ion implantation device and a method of manufacturing a semiconductor device is described, wherein ionized boron hydride molecular clusters are implanted to form P-type transistor structures. For example, in the fabrication of Complementary Metal-Oxide Semiconductor (CMOS) devices, the clusters are implanted to provide P-type doping for Source and Drain structures and for Polygates; these doping steps are critical to the formation of PMOS transistors. The molecular cluster ions have the chemical form BnHx+ and BnHx−, where 10≦n≦100 and 0≦x≦n+4.
US08410456B2 Measurement data correction method, optical tomography measurement device and storage medium stored with program
A measurement data correction method is provided. A living organism is employed as a test sample, fluorescent light generated by excitation light from a fluorescent substance administered to the test sample is received by a light receiving component at a plurality of locations around the periphery of the test sample in a flat plane passing through an observation site of the test sample, and the method is employed for reconstruction of an optical tomographic image of the test sample along the flat plane passing through the observation site. The method includes: generating corrected measurement data, as measurement data to be used in reconstruction of an optical tomographic image along the flat plane passing through the observation site of the test sample, from an obtained first measurement data and an obtained first standardization measurement data using a defined correction coefficient.
US08410448B2 Imaging apparatus for generating an image of a region of interest
The present invention relates to an imaging apparatus for generating an image of a region of interest. The imaging apparatus comprises a radiation source (2), a detection unit (6) for generating detection data and a moving unit (1, 7, 8) for moving the radiation source (2) and the region of interest relative to each other, while the detection data are generated. The imaging apparatus further comprises an identification unit (13) for identifying in the detection data high density detection data and non-high density detection data. A density weighting unit (14) density weights the detection data, wherein at least a part of the high density detection data has a smaller density weight than the non-high density detection data, and a reconstruction unit (15) reconstructs an image of the region of interest from the weighted detection data.
US08410441B2 Thermal imaging camera for taking thermographic images
In a thermal imaging camera for acquisition of thermographic images of a measurement object, an electronic evaluation unit is integrated into the thermal imaging camera; it is designed for recognition of corresponding partial regions of the acquired thermographic images, and with it, the acquired images can be assembled into an overall image by overlapping the corresponding partial regions and displayed. The acquisition of the images preferably takes place during the swiveling of the thermal imaging camera over the solid angle region of the desired overall image.
US08410439B2 X-ray detector for electron microscope
Multiple detectors arranged in a ring within a specimen chamber provide a large solid angle of collection. The detectors preferably include a shutter and a cold shield that reduce ice formation on the detector. By providing detectors surrounding the sample, a large solid angle is provided for improved detection and x-rays are detected regardless of the direction of sample tilt.
US08410433B2 Mass spectrometer
A cathode configuration for emission of electrons has a reaction zone connected to an entrance opening for the supply of neutral particles. The opening communicates with the cathode configuration for the ionization of the neutral particles and an ion extraction system communicates with the reaction zone. Ions from the extraction system are sent to a detection system and a mechanism for the evacuation of the mass spectrometer arrangement. The cathode configuration includes a field emission cathode with an emitter surface, wherein at a short distance from this emitter surface, an extraction grid is disposed for the extraction of electrons, which grid substantially covers the emitter surface. The emitter surface encompasses herein at least partially a hollow volume such that a tubular structure is formed.
US08410430B2 Mass spectrometer
A Time of Flight mass analyser is disclosed wherein the time period between successive orthogonal acceleration pulses is less than the time of flight of ions having the maximum mass to charge ratio of interest. As a result, some ions are subject to wrap-around and will appear in a subsequent mass spectrum. Mass spectra obtained at two different sampling rates may be compared and mass peaks relating to ions which have and have not been subject to wrap-around may be identified.
US08410427B2 Semiconductor device, method for manufacturing semiconductor device, apparatus for manufacturing semiconductor device, and method for evaluating semiconductor device
The present teachings provide a method for manufacturing a semiconductor device including a semiconductor substrate and a lower surface electrode in which an aluminum containing layer, a titanium layer, a nickel layer, and a nickel oxidation-prevention layer are laminated in order from a semiconductor substrate side, wherein the titanium layer of the lower electrode is formed by sputtering in an atmosphere of a partial pressure of oxygen being equal to or less than 5×10−6 Pa.
US08410424B2 Multiple ion injection in mass spectrometry
This invention relates to mass spectrometry that includes ion trapping in at least one of the stages of mass analysis. In particular, although not exclusively, this invention relates to tandem mass spectrometry where precursor ions and fragment ions are analysed. A method of mass spectrometry is provided comprising the sequential steps of: accumulating in an ion store a sample of one type of ions to be analysed; accumulating in the ion store a sample of another type of ions to be analysed; and mass analysing the combined samples of the ions; wherein the method comprises accumulating the sample of the one type of ions and/or the sample of another type of ions to achieve a target number of ions based on the results of a previous measurement of the respective type of ions.
US08410422B2 Method and arrangement for the adjustment of characteristics of a beam bundle of high-energy radiation emitted from a plasma
The invention is related to the adjustment of characteristics of a beam bundle of high-energy radiation emitted from a plasma, particularly for applications in semiconductor lithography. For acquiring and adjusting characteristics of a beam bundle of high-energy radiation emitted from a plasma and focused by means of collector optics, an intensity distribution of the radiation is acquired over the cross section of a convergent beam bundle in a measuring plane perpendicular to the optical axis in front of an intermediate focus of the collector optics, and intensity values are recorded in defined sectors for a quantity of reception regions of a measuring device which are aligned with different radii concentric to the optical axis, and measured quantities and control variables are determined from a comparison of the intensity values of different sectors for aligning the collector optics.
US08410419B2 Optical navigation device with illumination optics having an image outside a detector field of view
An optical navigation device includes an image sensor, a light source, and illumination optics. The image sensor generates images of a tracking surface. The image sensor has a field of view via imaging optics interposed between the image sensor and the tracking surface. The light source generates light to illuminate a portion of the tracking surface. The illumination optics are interposed between the light source and the tracking surface to direct the light from the light source toward the tracking surface. The illumination optics include an output surface with a primary region illuminated above a threshold intensity. The illumination optics are located relative to the tracking surface so that an image of the output surface excludes the primary region from the field of view of the image sensor.
US08410418B2 Solid-state imaging device, method for manufacturing the same, and imaging apparatus
Realization of an adequate hole accumulation layer and reduction in dark current are allowed to become mutually compatible. A solid-state imaging device 1 having a light-receiving portion 12 to photoelectrically convert incident light is characterized by including a film 21, which is disposed on a light-receiving surface 12s of the above-described light-receiving portion 12 and which lowers an interface state, and a film 22, which is disposed on the above-described film 21 to lower the interface state and which has a negative fixed charge, wherein a hole accumulation layer 23 is disposed on the light-receiving surface 12s side of the light-receiving portion 12.
US08410416B2 Reduction of delay between subsequent capture operations of a light-detection device
Disclosed are a system, a method and an apparatus of reduction of delay between subsequent capture operations of a light-detection device. In one embodiment, a light-detection circuit includes an avalanche photodiode implemented in a deep submicron CMOS technology. In addition, the light-detection circuit includes a passive quench control circuit to create an avalanche current that generates a high voltage at an output of a second inverter gate of the circuit. The light-detection circuit further includes an active quench control circuit to reduce a dead time of the circuit. The light-detection circuit also includes a reset circuit to create a low voltage at an output of the second inverter gate and to create an active reset through a PMOS transistor of the light-detection circuit.
US08410415B2 Ion detector for mass spectrometry, method for detecting ion, and method for manufacturing ion detector
The present disclosure provides an ion detector for improving the effect of electric field for pulling in an ion to be detected to a first-stage electrode of a secondary electron multiplier (SEM), and improving the effect of a stray light reduction. In one example embodiment, an ion detector includes a SEM, and a lead-in electrode for pulling in an ion to a first-stage electrode side of the SEM. At least one of the area of the lead-in electrode and a potential difference between the lead-in electrode and neighboring electrodes of the lead-in electrode, the neighboring electrode being an electrode not of the SEM, is set so that the light amount of internal-stray light generated inside the detector entering the first-stage electrode is not more than that of external-stray light generated outside the detector entering the first-stage electrode, when an ion is introduced into the detector.
US08410414B2 Fluorescence microscopy imaging system
A fluorescence microscopy imaging system is used for detecting a fluorescence signal of a sample, and includes a module for detecting fluorescence and a module for focusing control. The module for detecting fluorescence includes a fluorescence excitation light source generator (FELSG) and a fluorescence detector. The FELSG is capable of generating an excitation light beam having a first wavelength to excite the sample to emit fluorescence. The fluorescence detector is used to read the fluorescence signal of the sample. The module for focusing control generates a servo light beam having a second wavelength. A servo light beam reflecting film disposed on an observation plane is used to reflect the servo light beam. A return beam signal is analyzed using a focusing detection method. An actuator is used to move the objective for focusing, so as to enable the fluorescence excitation light beam to excite the sample to emit fluorescence.
US08410413B2 Method of varying firing range and effect in target for shell and shell configured for this purpose
The present invention relates to a method and a shell (1) for achieving variable firing range and effect when firing from a launcher, which shell (1) contains a firing charge (10), a rocket motor charge (6) with gas outlet (8), a rocket motor nozzle (9) and an active part (5). According to the invention, this is achieved by virtue of the fact that the shell (1) also contains a release mechanism (15) for releasing the rocket motor nozzle (9) from the rocket motor charge (6) after a time delay determined with regard to firing range and effect, and that the rocket motor charge (6) comprises a propellant which is detonable.
US08410412B2 Guidance control for spinning or rolling vehicle
A projectile, air vehicle or submersible craft with a spinning or rolling fuselage, rotating on its axis, has a collar which can be positioned relative to a longitudinal axis of the projectile using aerodynamic forces. Aerodynamic surfaces, such as lift-producing surfaces, for example tails or canards, are coupled to the collar, and rotate with the collar. An actuator system or mechanism controls orienting of the lift-producing surfaces, such as tilting of the lift producing surfaces, to direct the collar into a desired position relative to a longitudinal axis of the projectile, and to maintain the collar in that position. With such a control the projectile is able to be steered using bank-to-turn maneuvering. The actuator system may use any of a variety of mechanisms to move the lift-producing surfaces, thereby positioning the collar.
US08410409B1 Flexible coil segments for high efficiency inductors
An apparatus may have a tool die for forming a component. The tool die may have a die susceptor having a forming surface for forming the component, and at least one flexible induction coil segment for heating the die susceptor. The at least one flexible induction coil segment may be configured to conform to a contour of the forming surface of the die susceptor.
US08410405B2 Temperature control system
A temperature control system includes a temperature sensing module, a temperature control module, a pulse width modulation control module, a heating module, a heat dissipating module, and a switch module. The temperature sensing module is configured to obtain a current ambient temperature in a test box. The temperature control module is configured to output a control signal according to a difference between the current ambient temperature and a reference temperature. The pulse width modulation control module is configured to output a pulse width modulation signal according to the control signal. The switch module is configured to instruct the heating module or the heat dissipating module according to the pulse width modulation signal to keep the current ambient temperature generally equal to the reference temperature in the test box.
US08410400B2 Welded metal laminate structure and method for welding a metal laminate structure
An improved method for welding a laminated metal structure is presented herein. In one embodiment, the method includes: placing the laminated structure against a second work piece, feeding a consumable metal cored wire electrode to the weld zone, feeding a stream of shielding gas to the weld zone, and melting the consumable metal cored wire electrode. If the weld joint is a plug weld, the method also includes forming a plug hole in one of the work pieces, melting the consumable metal cored wire electrode along the circumference of the plug hole, and thereafter progressively spiraling the welding gun inwards towards the center of the plug hole to fill it with the melted electrode. The method may also include determining if melting the electrode is causing sputtering, and delaying spiraling the welding gun inwards until the sputtering subsides. A welded laminate metal structure is also provided herein.
US08410398B2 Method and apparatus for characterizing a welding output circuit path
Methods and apparatus to characterize a welding output circuit path. A welding output circuit path is characterized in real time with respect to at least one of a true energy and true power input to the welding output circuit path.
US08410394B2 Method and apparatus for processing substrate edges
A method and apparatus for processing substrate edges is disclosed that overcomes the limitations of conventional edge processing methods and systems used in semiconductor manufacturing. The edge processing method and apparatus of this invention includes a laser and optical system to direct a beam of radiation onto a rotating substrate supported by a chuck. The optical system accurately and precisely directs the beam to remove or transform organic or inorganic films, film stacks, residues, or particles, in atmosphere, from the top edge, top bevel, apex, bottom bevel, and bottom edge of the substrate in a single process step. An optional gas injector system directs gas onto the substrate edge to aid in the reaction. Reaction by-products are removed by means of an exhaust tube enveloping the reaction site. This invention permits precise control of an edge exclusion width, resulting in an increase in the number of usable die on a wafer. Wafer edge processing with this invention replaces existing methods that use large volumes of purified water and hazardous chemicals including solvents, acids, alkalis, and proprietary strippers.
US08410385B2 Keypad assembly and electronic device using the same
A keypad assembly includes a support member, a key switch, a keycap, and a resilient member. The key switch is fixed on the support member and includes a triggering portion. The keycap is located opposite to the triggering portion. The resilient member includes a rotation portion and a resilient support portion connected to the rotation portion. The rotation portion is rotatably connected to the keycap and the support member. The resilient support portion is elastically deformed via resisting the support member when the key switch is not triggered, and provides an elastic restoring force to the rotation portion.
US08410384B2 Actuating device
An actuating device (1), generating an electrical switching signal, comprising a housing (2) and a cover (4) which is held in a groove (8) worked into the housing, and a switching contact (6) attached in the interior (21) of the housing (2), the switching contact (6) is moved from an initial position (a) to a switching position (b) by closure of the cover (4) either directly or by intermediate elements (19) attached to the cover (4), a reliable and positionally accurate closure of the cover (4) in order to generate a switching contact, even if the cover (4) has an off-center actuation force applied to it is achieved because at least one abutment (11) is attached facing the cover (4) on the base (23) of the housing, and has a support surface (17) corresponding to the movement of the cover (4) mounted in the groove (8), and at least one bearing element (12) is attached to the cover (4) which, when the cover (4) is in its assembled status, makes contact with the support surface (17) of the abutment (11) and is thus supported when the cover (4) is actuated.
US08410382B2 Operation panel device for an elevator
In an operation panel device for an elevator, a switch provided with a switch main body and an operation portion is mounted onto the back surface of a faceplate. A retaining mechanism for retaining the switch main body in a predetermined mounting position is provided between a side surface of the switch main body and the back surface of the faceplate. The retaining mechanism includes an elastic member. The elastic member allows the switch main body to be moved to the mounting position by elastic deformation. Further, when the switch main body is moved to the mounting position, the elastic member is restored to an original state thereof to prevent the switch main body from moving from the mounting position.
US08410374B2 Printed wiring board
A printed wiring board has an insulative board having a first surface and a second surface on the opposite side of the first surface, a wiring formed on the first surface of the insulative board and having a pad and a conductive circuit contiguous to the pad, and a metal film formed on the pad. The pad is provided to mount an electronic component having a gold bump. The pad has a thickness which is greater than a thickness of the conductive circuit.
US08410369B2 Breakaway mechanism for charging cables of electric vehicle charging stations
A breakaway mechanism for a charging cable of an electric vehicle charging station includes a retention component and a breakaway component. The retention component is secured to the charging station and the breakaway component is secured to the charging cable. The charging cable passes through the breakaway component and includes charging wires that connect to connectors on the charging station. The breakaway component is adapted to disengage from the retention component at a predetermined pull force thereby causing the charging wires to disconnect from the connectors on the charging station.
US08410367B2 Electric contact member
Provided is an electric contact member which reduces, to the utmost, peel-off of a carbon film that is caused at the time of use of the electric contact member having at least an edge to keep stable electric contact over a long period of time. Disclosed is an electric contact member which repeatedly contacts with a device under test at a tip part of the electric contact member in which the tip part has an edge, the electric contact member comprising: a base material; an underlying layer comprising Au, Au alloy, Pd or Pd alloy, which is formed on a surface of the base material of the tip part; an intermediate layer which is formed on a surface of the underlying layer; and a carbon film comprising at least one of a metal and a carbide thereof which is formed on a surface of the intermediate layer, wherein the intermediate layer has a lamination structure comprising: an inner layer comprising Ni or Ni alloy; and an outer layer comprising at least one of Cr, Cr alloy, W and W alloy.
US08410362B1 Fixing structure for the faceplate ventilation screen of a power source supplier
A fixing structure for the faceplate ventilation screen of a power source supplier includes a faceplate body and at least one ventilation screen. The faceplate body has an inner side formed with at least two first extension portions protruding out vertically in the same direction, and the two first extension portions have their opposite inner sides respectively provided with a first position-limiting member extending oppositely at a location adjacent to the faceplate body. The first position-limiting members are parallel to the faceplate body, and a first gap is formed between the first position-limiting members and the faceplate body for receiving two ends of the ventilation screen. The first position-limiting members can be deformed by external force toward the faceplate body for firmly fixing the ventilation screen on the faceplate body.
US08410360B2 Sealing structure for wire lead-out hole
A sealing structure for wire lead-out hole is provided with a wire lead-out hole (11) formed in a case (10), a resilient seal (20) to be mounted into the wire lead-out hole (11), and a bracket (40) for retaining the resilient seal (20) in the wire lead-out hole (11) by being fixed to the case (10). The resilient seal (20) includes a seal main body (21) including a plurality of wire insertion holes (22) for allowing insertion of wires (Y), outer lips (24) formed on the outer peripheral surface of the seal main body (21), inner lips (23) formed on the inner peripheral surfaces of the wire insertion holes (22), and a wire protecting portion (25) provided on the seal main body (21).
US08410358B2 Electronic device enclosure
An electronic device enclosure includes an enclosure body, a bezel, a resilient locking clip, and an unlocking clip. An opening is defined in the enclosure body. The bezel assembly is mounted to the enclosure body and covers the opening. The resilient locking clip is attached to the enclosure body. A protrusion is located on the resilient clip. The unlocking clip is attached to the bezel assembly and is operable along a first direction. The unlocking clip is capable of being rotated from a first position to a second position. In the first position, the resilient locking clip blocks the bezel assembly from moving along the first direction. In the second position, the resilient clip is disengaged from the bezel by the unlocking clip.
US08410352B2 Method of fabricating photovoltaic cells
The invention relates to a method of fabricating photovoltaic cells in which at least one layer of semiconductor material is deposited continuously on a carbon ribbon (10) to form a composite ribbon (20), said layer having a free face (22, 24) opposite from its face in contact with the carbon ribbon. According to the invention, at least one treatment (28) is applied to the layer of semiconductor material, from said free face (22, 24), in order to implement photovoltaic functions of the cells on said layer, prior to eliminating the carbon ribbon (10). The invention makes it possible to increase productivity in the fabrication of photovoltaic cells, which cells can be of very small thicknesses.
US08410350B2 Modular solar panels with heat exchange
A photovoltaic module with photovoltaic cell and a heat sink. The heat sink is attached on a side of the cell opposite to the light-receiving side of the photovoltaic cell. The heat sink can remove heat caused by light absorbed by the photovoltaic cell but not converted to electricity as well as heat generated by resistance to high current passing through electrodes of the photovoltaic cell. A photovoltaic module formed of such cells can exhibit greater energy conversion efficiency as a result of the ability to dissipate the heat. A method of making a solar module involves e.g. laminating a heat sink to a photovoltaic cell.
US08410345B2 Tone control device for percussion instruments
Herein described is a tone control device for percussion instruments comprising a first strap, a second strap, a weighted member and an engagement loop for the convenient engagement of a drum stick or other striking implement. The device attaches to a percussion instrument in such a manner as to allow a user to apply the tone control device to the percussion instrument's strike surface efficiently and conveniently with minimal disruption in play.
US08410335B2 Method for producing rose with altered petal colors
A method for producing a rose characterized by artificially suppressing the rose endogenous metabolic pathway and expressing the pansy gene coding for flavonoid 3′,5′-hydroxylase.
US08410329B2 Ethylene separation
A polyethylene production process, comprising contacting ethylene and a polymerization catalyst under suitable reaction conditions to yield a polymerization product stream, separating a light gas stream from the polymerization product stream, wherein the light gas stream comprises ethane and unreacted ethylene, contacting the light gas stream with an absorption solvent system, wherein at least a portion of the ethylene from the light gas stream is absorbed by the absorption solvent system, removing unabsorbed gases of the light gas stream from contact with the absorption solvent system to form a waste gas stream, and recovering ethylene from the absorption solvent system.
US08410320B2 Method for synthesis of secondary alcohols
A method for synthesis of secondary alcohols is provided for pharmaceutical secondary alcohol by addition of organoboronic acids with aldehydes in presence of the cobalt ion and bidentate ligands as the catalyst. In addition, an enantioselective synthesis method for secondary alcohols is also herein provided in the present invention. The present invention has advantages in using less expensive cobalt ion and commercially available chiral ligands as the catalyst, wide scope of organoboronic acids and aldehydes compatible with this catalytic reaction and achieving excellent yields and/or enantiomeric excess.
US08410317B2 Process for the preparation of 1,4-cyclohexanedimethanol
Disclosed is a process for the preparation of 1,4-cyclohexanedimethanol from terephthalic acid. Terephthalic acid is esterified with (4-methylcyclohexyl)methanol and the terephthalate ester hydrogenated to 1,4-cyclohexanedimethanol in a 2-stage process. The (4-methylcyclohexyl)methanol that is formed during the hydrogenation step is recycled to the esterification reaction. After removal of the (4-methylcyclohexyl)methanol from the crude hydrogenation product, the 1,4-cyclohexanedimethanol product can be recovered and purified by a phase separation and distillation.
US08410315B2 Method for producing olefinically unsaturated carbonyl compounds by oxidative dehydrogenation of alcohols
A process for preparing olefinically unsaturated carbonyl compounds by oxidative dehydrogenation in an oxygenous atmosphere over a supported catalyst which comprises gold and optionally further noble metals at temperatures in the range from 50 to 240° C.
US08410312B2 Fluorination process of anilide derivatives and benzothiazole fluorinate derivatives as in vivo imaging agents
The invention relates to a process for preparation of a compound of formula (I): R1 is selected from C1-6alkyl, C2-6alkenyl, and C2-6alkynyl; which comprises: (i) reaction with fluoride, suitably [18F]fluoride, of a corresponding compound of formula (II): wherein R2 is selected from hydrogen, C1-10alkyl, C1-10haloalkyl, C6-14aryl, C6-14arylalkyl, —(CH2CH2O)q—CH3 wherein q is an integer of from 1 to 10; R1 is as defined for the compound of formula (I); and R3 is a leaving group. Certain novel precursors of formula (II) and radiopharmaceutical kits containing such precursors are also claimed.
US08410311B1 Fluorescent cytotoxic compounds specific for the cellular polyamine transport system
Cyano-substituted anthracene containing polyamines were synthesized and shown to be efficient polyamine transporter ligands. Moreover, these compounds (3 and 4) had improved fluorescence properties over previously known anthryl-polyamine conjugates, which facilitated their intracellular trafficking by confocal microscopy. These cytotoxic fluorescent agents may find use as molecular probes which traffic into cells via the polyamine transport system and may also be viable anticancer drugs which are readily quantified in human tissues due to their excellent fluorescence properties: (excitation: λ 405 nm) and emission (420 nm) occurs in the visible light range. The ability to excite and emit in the visible range provides an advantage to these probes as these wavelengths are not toxic to human cells (versus ultraviolet mediated excitations, λ<400 nm) and visible light lasers are less costly to purchase and operate than UV laser sources.
US08410303B2 Direct conversion of phenols into amides and esters of benzoic acid
A method is provided for the preparation of an aromatic carboxylic acid aryl ester or an N-aryl aromatic carboxamide. The method comprises contacting an O,O-diaryl thiocarbonate or an O-aryl-N-aryl thiocarbamate with a reactant that regioselectively reacts with sulfur, which contact causes an O-neophyl rearrangement, thereby forming either the aromatic carboxylic acid aryl ester or the N-aryl aromatic carboxamide, respectively.
US08410301B2 Methods for the synthesis of organic sulfides by using sulfides and organic sulfur-indium complexes
The present invention relates to a novel synthesis method for the formation of carbon-sulfur bonds by the reaction of an organic sulfur-indium complex with nucleophile in the presence of a palladium catalyst. The present invention provides a synthesis method to prepare several kinds of organic sulfides which are difficult to be prepared by the conventional synthesis methods. A short reaction time and quantitative yield are the advantages of this method. In addition, several kinds of organic sulfide can be prepared by the selection of nucleophile and organic sulfur-indium complex to be used.
US08410300B2 Protease inhibitors
The present invention provides HIV protease inhibitors of formulas I, IA, IB, Ib or II, or pharmaceutically acceptable salts thereof, wherein R2 may be, for example, 2-pyridyl-CH2—, 3 -pyridyl-CH2—, 4-pyridyl-CH2—, a sulfonyl group as described in the formulas herein including benzenesulfonyl or thiophenesulfonyl groups, R2a—CO—, R2a being selected from the group consisting of piperonyl, 2-pyrazinyl (unsubstituted or substituted with H, or an alkyl of 1 to 4 carbon atoms) or a picolylamine group as described herein, wherein R3 may be, for example, a phenyl group or diphenylmethyl group as described herein, and wherein Cx may be, for example, COOH, CONR5R6, CH2OH or CH2OR7.
US08410280B2 Process for preparing transition metal-carbene complexes
Process for preparing cyclometallated transition metal-carbene complexes comprising at least one carbene ligand, which comprises reacting a ligand precursor with a base, an auxiliary reagent and a metal complex comprising at least one metal M1 (route A) or reacting the ligand precursor with a basic auxiliary reagent and a metal complex comprising at least one metal M1 (route B). The present invention further relates to the use of an auxiliary reagent selected from among salts comprising at least one metal selected from the group consisting of Ag, Hg, Sb, Mg, B and Al together with a base in a process for preparing cyclometallated metal complexes.
US08410277B2 Method for manufacturing heterocycle substituted pyridine derivatives
It is an object of the present invention to provide an efficient method for manufacturing heterocycle-substituted pyridine derivatives. The present invention provides a method for manufacturing a compound represented by the following formula (I): the method including reacting a compound represented by the following formula (III): and a compound represented by the following formula (II): in a solvent and in the presence of a palladium catalyst and a base, wherein R1 represents a hydrogen atom, etc.; R2 represents a hydrogen atom, a C1-6 alkyl group, an amino group that may be protected with a protective group, etc.; one of X and Y represents a nitrogen atom and the other represents a nitrogen atom or an oxygen atom; Q represents a leaving group; the ring A represents a 5- or 6-member heteroaryl ring or a benzene ring, which may have one or two halogen atoms or C1-6 alkyl groups; Z represents a single bond, a methylene group, an ethylene group, an oxygen atom, etc.; R represents a hydrogen atom or a C1-6 alkyl group, etc.; R3 represents a hydrogen atom or a halogen atom, etc.; and R4 represents a hydrogen atom or a halogen atom; provided that when Z represents a single bond, or when R3 represents a hydrogen atom, then R1, R2, and R4 cannot all be a hydrogen atom at the same time.
US08410274B2 Solid forms of N-[2,4-bis(1,1-dimethylethyl)-5-hydroxyphenyl]-1,4-dihydro-4-oxoquinoline-3-carboxamide
The present invention relates to solid state forms of N-[2,4-bis(1,1-dimethylethyl)-5-hydroxyphenyl]-1,4-dihydro-4-oxoquinoline-3-carboxamide (Compound 1), pharmaceutical compositions thereof and methods therewith.
US08410273B2 Cyclic compound having substituted phenyl group
Low molecular weight compound exhibiting an osteogenesis-promoting action having the general formula (I) or a pharmacologically acceptable salt thereof:
US08410263B2 High-purity texaphyrin metal complexes
Disclosed herein are the methods and compositions for the improved synthesis of texaphyrin metal complexes. The improved synthesis results in high-purity compositions of texaphyrin metal complexes in which more than about 98% of the texaphyrin metal complexes in the composition have the same structure and/or the same molecular weight. Further described herein are pharmaceutical compositions comprising such high-purity compositions, and the use of such high-purity compositions in the treatment of cancer and cardiovascular diseases and disorders.
US08410262B2 Process for the preparation of hydroxy polymer esters and their use
This invention covers a novel method for the preparation of hydroxy polymer esters of amino, alkylamino and quaternary ammonium acids and their use in several fields of industry, including the use as additives in the manufacture of paper or paperboard. The esterification of the hydroxy polymer, preferably starch, is performed under semianhydrous conditions by heating homogenized mixtures of the hydroxy polymer and reagents.
US08410261B2 Compositions and methods for inhibiting expression of a gene from the JC virus
The invention relates to a double-stranded ribonucleic acid (dsRNA) for inhibiting the expression of a gene from the JC Virus (JC virus genome), comprising an antisense strand having a nucleotide sequence which is less that 30 nucleotides in length, generally 19-25 nucleotides in length, and which is substantially complementary to at least a part of a gene from the JC Virus. The invention also relates to a pharmaceutical composition comprising the dsRNA together with a pharmaceutically acceptable carrier; methods for treating diseases caused by JC virus expression and the expression of a gene from the JC Virus using the pharmaceutical composition; and methods for inhibiting the expression of a gene from the JC Virus in a cell.
US08410252B2 ULBP2 polypeptides
The invention is directed to purified and isolated novel ULBP polypeptides, the nucleic acids encoding such polypeptides, processes for production of recombinant forms of such polypeptides, antibodies generated against these polypeptides, fragmented peptides derived from these polypeptides, and the uses of the above. ULBP polypeptide can be found on the surface of human B cell lymphomas. Mammalian forms of ULBP polypeptide in isolated or purified forms are provided. In addition, isolated nucleic acids encoding ULBP polypeptides and expression vectors comprising a cDNA encoding ULBP polypeptides are provided. The ULBP polypeptides can be isolated or synthesized and used to prepare antibodies, and in particular monoclonal antibodies, against the polypeptides. The antibodies, in turn, are useful for detecting the presence of ULBP polypeptides in human cell samples, which can be correlated with the existence of a malignant condition in a patient. ULBP polypeptides stimulate IFN-γ production, NK cell proliferation, and CTL activity.
US08410247B2 Water-soluble phosphinothiol reagents
Water soluble reagents and methods for the formation of an amide bond between a phosphinothioester and an azide in an aqueous medium. The phosphinothioester is generated using a water-soluble phosphinothiol reagent. This reaction allows formation of an amide bond between a wide variety of chemical species including amino acids, peptides or protein fragments in an aqueous solution. Of particular interest, this reaction allows for the formation of an amide bond in a physiological setting. In a specific embodiment, this invention provides reagents and methods for peptide ligation in an aqueous medium. The reaction eliminates the need for a cysteine residue and is traceless leaving no residual atoms in the ligated peptide product.
US08410241B2 Optical devices and their manufacture
A process for the preparation of a polymerizable unit for production of a hole transporting polymer for use in an optical device, which process comprises reacting in the presence of S to form wherein each R is the same or different and is independently H or a substituent group; n is O or an integer from 1 to 100; Ar and Ar′ are the same or different and are each aromatic or heteroaromatic groups which are substituted or unsubstituted; Y is a direct bond, a light emissive moiety, a hole transporting moiety or an electron transporting moiety; and X is a polymerizable group.
US08410236B2 Polycarbonate and/or polyurethane polyorganosiloxane compounds
The invention relates to novel polycarbonate- and/or polyurethane-polyorganosiloxane compounds, processes for their preparation, their use, precursors for their preparation and reactive compositions which contain the precursors.
US08410230B2 Polymerization processes for broadened molecular weight distribution
Provided are methods of producing polymers with broadened molecular weight and/or composition distribution in a continuous homogeneous polymerization system utilizing reactor temperature gradients, reactor polymer concentration gradients, monomer concentration gradients, catalyst concentration gradients, and combinations thereof in the polymerization reactor. Such methods are particularly suitable when utilizing metallocene catalysts and other single-site catalysts, which generally produce polymers with narrow molecular weight and composition distribution.
US08410228B2 Emulsion polymerisation process
An emulsion polymerization process using a redox initiator comprising a reductant and an oxidant, wherein monomers are mixed into a carrier liquid, e.g. water, to make a pre-emulsion, which is then supplied to a reactor comprising one or more circulation loops, an outlet, and a circulation pump for circulating a reactor charge within the circulation loop, characterized in that the reductant is added to the pre-emulsion before it is mixed into the reactor charge and the oxidant is mixed into the reactor charge, e.g., via the water-phase feed.
US08410225B2 Fluorescent nanoparticles
A fluorescent nanoparticle includes a core comprising an alkenylbenzene; an intermediate layer, an outer shell layer, and a fluorescent portion. The fluorescent portion includes a structure represented by the following formula: wherein L is a direct bond or a linker group, and F is any fluorescent moiety. The fluorescent portion is located in at least one of the following locations: the core, the intermediate layer, or the shell layer of the nanoparticle. Methods for making the fluorescent nanoparticle are also described.
US08410221B2 Process for producing water-absorbing polymer particles with low caking tendency and high absorption under pressure
A process for producing water-absorbing polymer particles with low caking tendency and high absorption under pressure, comprising polymerization of a monomer solution or suspension, drying of the resulting polymer gel, grinding, classifying, thermal surface postcrosslinking and coating with silicon dioxide, wherein the water-absorbing polymer particles have been coated, before, during or after the surface postcrosslinking with aluminum cations.
US08410216B2 Impact-resistant composition based on a polyamide resin and on a blend of at least one graft copolymer with polyamide blocks and a low-density ethylene polymer
The invention relates to a composition based on an impact-resistant thermoplastic polyamide resin, comprising, as a blend—from 60 to 98 wt % of polyamide resin (A) and—from 2 to 40 wt % of a blend of at least one graft copolymer with polyamide blocks (B) composed of a polyolefin backbone and at least one polyamide graft in which the grafts are attached to the backbone by the residues of an unsaturated monomer (X) having a functional group capable of reacting with an amine-terminated polyamide, the residues of the unsaturated monomer (X) being attached to the backbone by grafting or copolymerization via its double bond, and of a non-reactive ethylenic polymer (C) that is miscible with (B) and has a density of below 0.960 g/cm3.
US08410215B2 Thermoplastic resin composition and molded article obtained from the same
A thermoplastic resin composition contains (i) a polylactic acid, (ii) a polyolefin, and (iii) a compatibilizer (functional group-containing polymer that includes a functional group selected from functional groups X including a carboxyl group, an acid anhydride group, an epoxy group, a (meth)acryloyl group, an amino group, an alkoxysilyl group, a hydroxyl group, an isocyanate group, and an oxazoline group). The thermoplastic resin composition contains (iii-1) a functional group-containing hydrogenated diene polymer and (iii-2) a functional group-containing olefin polymer as the component (iii).
US08410211B2 Electrically neutral dispersions and method of preparing same
The invention is a method of producing an essentially electrically neutral polymer dispersion, comprising a polymerizing one or more monomers in the presence of a nonionic surfactant, wherein the polymerization preferably occurs in the absence of ionic surfactants. The invention also includes methods of producing positively or negatively charged polymer dispersions comprising producing the essentially nonionic polymer dispersion and further adding a cationically-charged or anionically-charged surfactant or electrolyte. The invention further includes dispersions produced by the methods of the invention and polymer films and powders produced from these dispersions.
US08410207B2 Thermoplastic, polymeric materials providing high IR absorption, method for the production thereof, and use thereof
Thermoplastic polymeric materials with high IR absorption are described, containing at least one inorganic metal phosphate of the general formula Mex(PO4)y(OH)z, wherein Me consists of one or more elements from the group Cu, Fe, Mn, Sb, Zn, Ti, Ni, Co, V, Mg, Bi, Be, Al, Ce, Ba, Sr, Na, K, Ge, Ga, Ca, Cr, In or Sn, and wherein x and y are whole numbers and x=(1 . . . 18), y=(1 . . . 12) and z=(0.2 . . . 10), and the inorganic metal phosphate may optionally also contain water of crystallization.
US08410206B2 Stabilization of organic polymers against free radicals
The invention concerns the use of cerium dioxide, especially in the form of discrete cerium dioxide particles with particle sizes in the range from 0.005 to 150 μm, as inorganic radical trap to stabilize organic polymers, especially in the form of polymer-based formulations, varnishes, paints, coating compounds, or the like, against their photochemically, thermally, physically and/or chemically induced degradation by free radicals, especially against the effect of UV, advantageously in an optional combination with at least one UV-absorber and/or at least one additional radical trap. The radical-induced degradation of the organic polymers is effectively prevented by the use of cerium dioxide without the cerium dioxide itself becoming degraded. If a combination of cerium dioxide with an additional UV-absorber or radical trap is used, its effectiveness is extended through the presence of the cerium dioxide.
US08410201B2 Procedure for preparation of a reflective and oxide inhibiting coating
The present invention refers a procedure for preparation of a reflective and oxide inhibiting coating consists of adding hard water, a series of compounds such as titanium dioxide, calcium hydroxide at 95%, an acrylic polymer, hydroxy methyl cellulose, sodium hexametaphosphate at 10% y monoethylen glycol, maintaining specific conditions of pH and viscosity during process. The resulting coating of this process, presents highly adhesive actions, as well as a high level of reflection to solar rays, which place it as a oxide inhibitor, that no require previous sealed when it is applied to steel and/or galvanize surfaces.
US08410196B2 Surface-modified nanodiamond and its producing method
A surface-modified nanodiamond includes a base nanodiamond, and at least one polyglycerol-chain-containing group present on at least a surface portion of the base nanodiamond, in which the polyglycerol-chain-containing group is represented by following Formula (1): —X—R   (1) wherein X represents single bond, —NH—, —O—, —COO—, —PH(═O)O—, or —S—; and R represents a polyglyceryl group. X may be single bond or —NH—. The surface-modified nanodiamond is highly soluble or dispersible satisfactorily stably in water and/or polar organic solvents.
US08410189B2 Crosslinked polyalkyleneimine hydrogels with tunable degradation rates
One aspect of the present invention relates to methods of sealing a wound or tissue plane or filling a void space, or securing meshes, films or other devices within the body. In certain embodiments, the wound is an ophthalmic, pleural or dural wound, or a hernia repair mesh. Remarkably, disclosed herein is the discovery that the use of certain crosslinkers in combination with polyalkyleneimines at specific concentrations can result in hydrogels with tunable degradation properties.
US08410188B2 Sealant for one-drop fill process
A sealant for a one drop fill process is characterized by curing through two steps consisting of photocure using visible light from which 400 nm or shorter wavelengths are cut off and thermal cure and, when in contact with a liquid crystal composition, is less contaminating to the liquid crystal composition with a photo radical initiator, and exhibits high adhesive strength to a substrate. The sealant contains (1) a titanocene photo radical initiator, (2) a photocuring resin, (3) a latent epoxy curing agent and, if necessary, (4) a monomer having at least two glycidyl ether groups per molecule as a thermosetting resin.
US08410186B2 Process for manufacturing porous epoxy with open pores and porous epoxy made therefrom
The present invention relates to a process for manufacturing a porous epoxy network, especially a porous epoxy membrane. The process according the present invention comprises the steps of: providing a reactant solution comprising an epoxy resin, a solvent and a curing agent; performing a first curing process to transform the reactant solution to a gel; and performing a second curing process to essentially remove the remaining solvent and transform the gel to form a porous epoxy network with open pores; wherein the curing agent is a tertiary amine.
US08410185B2 Porous polymeric materials for hydrogen storage
A porous polymer, poly-9,9′-spirobifluorene and its derivatives for storage of H2 are prepared through a chemical synthesis method. The porous polymers have high specific surface area and narrow pore size distribution. Hydrogen uptake measurements conducted for these polymers determined a higher hydrogen storage capacity at the ambient temperature over that of the benchmark materials. The method of preparing such polymers, includes oxidatively activating solids by CO2/steam oxidation and supercritical water treatment.
US08410182B2 Mixing device
Provided are electrokinetically-altered fluids (e.g., gas-enriched (e.g., oxygen-enriched) electrokinetic fluids) comprising an ionic aqueous solution of charge-stabilized oxygen-containing nanostructures in an amount sufficient to provide, upon contact with a cell, modulation of at least one of cellular membrane potential and cellular membrane conductivity. Further provided are the methods of making the electrokinetically-altered ionic aqueous fluid compositions. Particular aspects provide for regulating or modulating intracellular signal transduction associated by modulation of at least one of cellular membranes, membrane potential, membrane proteins such as membrane receptors, including but not limited to G-Protein Coupled Receptors (GPCR), and intercellular junctions (e.g., tight junctions, gap junctions, zona adherins and desmasomes). Other embodiments include particular methods of producing the electrokinetically-altered fluids. The electrokinetically-altered fluid compositions and methods of producing the fluid include electrokinetically-altered ionic aqueous fluids optionally in the form of solvated electrons stabilized with molecular oxygen.
US08410178B2 CIS 3,4-dihydroxy-2-(3-methylbutanoyl)-5-(3-methylbutyl)-4-(4-methylpentanoyl)cyclopent-2-en-1-derivatives, substantially enantiomerically pure compositions and methods
The present application provides cis 3,4-dihydroxy-2-(3-methylbutanoyl)-5-(3-methylbutyl)-4-(4-methylpentanoyl)cyclopent-2-en-1-one derivatives and substantially enantiomerically pure compositions thereof. These derivatives include (+)-(4S,5R)-3,4-dihydroxy-2-(3-methylbutanoyl)-5-(3-methylbutyl)-4-(4-methylpentanoyl)cyclopent-2-en-1-one, (−)-(4R,5S)-3,4-dihydroxy-2-(3-methylbutanoyl)-5-(3-methylbutyl)-4-(4-methylpentanoyl)cyclopent-2-en-1-one, and salts and crystals thereof. The application further provides methods of using the disclosed compounds and compositions to activate PPARγ, activate GPR120, inhibit inflammation, and treat conditions responsive to PPARγ modulation, conditions responsive to GPR120 modulation, and metabolic disturbances such as diabetes.
US08410177B2 Curcumin derivatives
A compound has Formula VIII where, X is —C(O)R, —C(O)OR, —CN, —NO2, —S(O)2R′, —P(O)(OR)2; each R is individually H, alkyl, or alkenyl; R′ is alkyl or akenyl; R1 is aryl, alkenyl, arylalkenyl, heterocyclyl, or heteroaryl; and R2, R3, R4, R5, R6, R7, R8, R9, R10, and R11 are individually H, alkoxy, or hydroxy. In some cases, X is NO2. Pharmaceutical compositions of the compound of Formula VIII with a pharmaceutically acceptable carrier may be prepared. The compounds may be used for inhibition of cyclooxygenase-2.
US08410176B2 Intermediate compounds and processes for the preparation of tapentadol and related compounds
The present invention discloses processes for the preparation of 3-[(1R,2R)-3-(dimethyl-amino)-1-ethyl-2-methyl-propyl]phenol (Tapentadol), salts thereof and related compounds of formula (A), including stereoisomers and pharmaceutically acceptable salts thereof, and to certain intermediates used in such process.
US08410169B2 Compounds and methods for delivery of prostacyclin analogs
This invention pertains generally to prostacyclin analogs and methods for their use in promoting vasodilation, inhibiting platelet aggregation and thrombus formation, stimulating thrombolysis, inhibiting cell proliferation (including vascular remodeling), providing cytoprotection, preventing atherogenesis and inducing angiogenesis. Generally, the compounds and methods of the present invention increase the oral bioavailability and circulating concentrations of treprostinil when administered orally. Compounds of the present invention have the following formula:
US08410168B2 Methods and compositions for treating ophthalmic conditions with retinyl derivatives
Compounds that cause reversible night blindness may be used to treat ophthalmic conditions associated with the overproduction of waste products that accumulate during the course of the visual cycle. We describe methods and compositions using such compounds and their derivatives to treat, for example, the macular degenerations and dystrophies or to alleviate symptoms associated with such ophthalmic conditions. Such compounds and their derivatives may be used as single agent therapy or in combination with other agents or therapies.
US08410165B2 Aldehyde conjugated flavonoid preparations
There is provided a method of conjugating a polymer containing a free aldehyde group with a flavonoid in the presence of an acid catalyst, such that the polymer is conjugated to the C6 or C8 position of the flavonoid A ring. The resulting conjugates may be used to form delivery vehicles to deliver high doses of flavonoids, and may also be used as delivery vehicles to deliver an additional bioactive agent.
US08410161B2 Thioxanthone ring system derivatives
A thioxanthone ring system derivative compound is provided. The thioxanthone ring system derivative compound is represented by a formula (I): wherein X is a substituent being one selected from a group consisting of halogens, wherein R1 is a substituent being one selected from a group consisting of sulfur and sulfur dioxide, wherein R2 is a substituent being one selected from a group consisting of C1˜C10 alkyl group, C3˜C10 branched alkyl group, C3˜C10 cyclic alkyl group, phenyl group, phenyl alkyl group, and wherein hydrogen of phenyl group can be partially substituted by halogens, alkoxyl group, C1˜C10 alkyl group, nitro group or amine group.
US08410159B2 Imidazole compounds having pharmaceutical activity towards the sigma receptor
The present invention relates to compounds of formula (I), methods for their preparation, medicaments comprising these compounds as well their use in the manufacture of a medicament for the treatment of humans and animals.
US08410158B2 Inhibitors of Akt activity
Invented are novel heterocyclic carboxamide compounds, the use of such compounds as inhibitors of protein kinase B activity and in the treatment of cancer and arthritis.
US08410155B2 Arylpropionamide, arylacrylamide, arylpropynamide, or arylmethylurea analogs as factor XIA inhibitors
The present invention provides compounds of Formula (I) or (II): or a stereoisomer, tautomer, pharmaceutically acceptable salt or solvate form thereof, wherein the variables A, L1, R3, R4, R8a, R11 and M are as defined herein. The compounds of Formula (I) or (II) are selective inhibitors of serine protease enzymes of the coagulation cascade and/or contact activation system; for example thrombin, factor Xa, factor XIa, factor IXa, factor VIIa and/or plasma kallikrein. In particular, it relates to compounds that are selective factor XIa inhibitors or dual inhibitors of fXIa and plasma kallikrein. This invention also relates to pharmaceutical compositions comprising these compounds and methods of treating thromboembolic and/or inflammatory disorders using the same.
US08410153B2 Naphthalene isoxazoline invertebrate pest control agents
Disclosed are compounds of Formula 1, wherein R1 is halogen, C1-C2 haloalkyl or C1-C2 haloalkoxy; R2 is H, halogen or cyano; R3 is H, halogen or CF3; R4 is H, C2-C7 alkylcarbonyl or C2-C7 alkoxycarbonyl; and R5 is C1-C6 alkyl or C1-C6 haloalkyl, each substituted with one substituent independently selected from hydroxy, C1-C6 alkoxy, C1-C6 alkylthio, C1-C6 alkylsulfinyl, C1-C6 alkylsulfonyl, C2-C7 alkylaminocarbonyl, C3-C9 dialkylaminocarbonyl, C2-C7 haloalkylaminocarbonyl and C3-C9 halodialkylaminocarbonyl. Also disclosed are compositions containing the compounds of Formula 1 and methods for controlling an invertebrate pest comprising contacting the invertebrate pest or its environment with a biologically effective amount of a compound or a composition of the invention.
US08410152B2 Thiazolhydrazides for treatment of neurodegenerative diseases
Described are compounds having a thiazolhydrazide scaffold, pharmaceutically acceptable salts of these compounds and pharmaceutical compositions containing at least one of these compounds together with pharmaceutically acceptable carrier, excipient and/or diluents. Said thiazolhydrazide compounds can be used for prophylaxis and/or treatment of neurodegenerative diseases and conditions.
US08410148B2 Method and composition for potentiating an opiate analgesic
Composition and methods of treating pain and reducing or reversing tolerance to opiate analgesics are disclosed. The composition and method utilize an opiate analgesic and an endothelin antagonist as active agents to treat pain in mammals, including humans.
US08410140B2 Anesthetic methods and compositions
The present invention relates to compositions and methods use in pain reduction, including but not limited to, peripheral nerve blocks. In particular, the present invention relates to compositions and methods for the administration of perineural dexmedetomidine and ropivacaine in combination for increased antinociception in peripheral nerve blocks. In addition, this invention relates to any use of dexmedetomidine alone or in combination with other agents for the purpose of decreasing inflammation around peripheral nerves, thereby decreasing the potential for peripheral nerve injury. Further, the invention relates to the use of dexmedetomidine to reduce inflammation in the muscle to lessen or prevent muscle damage.
US08410136B2 Methods for treatment of hepatocellular carcinoma using 3-(4-amino-1-OXO-1,3-dihydroisoindol-2-yl)-piperidine-2,6-dione
Methods of treating, preventing and/or managing cancer as well as and diseases and disorders associated with, or characterized by, undesired angiogenesis are disclosed. Specific methods encompass the administration of an immunomodulatory compound alone or in combination with a second active ingredient. The invention further relates to methods of reducing or avoiding adverse side effects associated with chemotherapy, radiation therapy, hormonal therapy, biological therapy or immunotherapy which comprise the administration of an immunomodulatory compound. Pharmaceutical compositions, single unit dosage forms, and kits suitable for use in methods of the invention are also disclosed.
US08410134B2 8-oxy-quinoline derivatives as bradykinin B2 receptor modulators
The present invention is related to compound of the formula (I): or a pharmacologically acceptable salt, solvate, or hydrate thereof, wherein A is a 6-membered heteroaryl having from 1 to 3 heteroatoms, each independently selected from N or O and the other substituents are defined as in the claims.
US08410133B2 Aminopyridines useful as inhibitors of protein kinases
The present invention relates to compounds useful as inhibitors of protein kinases. The invention also provides pharmaceutically acceptable compositions comprising those compounds, the methods of using the aforementioned compounds, and compounds in the treatment of various diseases, conditions, and disorders. The invention also provides processes for preparing compounds of the invention.
US08410132B2 Modulators of cystic fibrosis transmembrane conductance regulator
The present invention relates to modulators of ATP-Binding Cassette (“ABC”) transporters or fragments thereof, including Cystic Fibrosis Transmembrane Conductance Regulator, compositions thereof, and methods therewith. The present invention also relates to methods of treating ABC transporter mediated diseases using such modulators.
US08410126B2 Pyrimidine inhibitors of PKTK2
Compounds of general formula (1) wherein A, B, R1 to R5, Rx m, n and p are defined as described in the specification, which are suitable for the treatment of diseases characterized by excessive or abnormal cell proliferation, pharmaceutical preparations which contain such compounds and the use thereof [as] medicaments.
US08410118B2 Inhibitors of fatty acid uptake and methods of use
The present disclosure describes inhibitors of fatty acid uptake and methods of using such inhibitors. Specifically, the present disclosure describes inhibitors with specificity for FATP2.
US08410115B2 Methods of treating inflammatory and autoimmune diseases with alpha-4 inhibitory compounds
Alpha 4 inhibitors are used in treatment of inflammatory and autoimmune diseases, such as multiple sclerosis, Crohn's Disease, rheumatoid arthritis and asthma. Rare occurrences of progressive multifocal leucoencephalopathy during treatment with an alpha-4 agent suggest the possibility that it may be related to such treatment. Monitoring for the JC virus and educating caregivers and patients about the manifestations of progressive multifocal leucoencephalopathy can improve the safety of alpha 4 inhibitor therapy.
US08410109B2 Pharmaceutical compositions for the prevention and treatment of complex diseases and their delivery by insertable medical devices
The present invention relates to polyphenol-like compounds that are useful for inhibiting VCAM-1 expression, MCP-1 expression and/or SMC proliferation in a mammal. The disclosed compounds are useful for regulating markers of inflammatory conditions, including vascular inflammation, and for treatment and prevention of inflammatory and cardiovascular diseases and related disease states.
US08410107B2 N-pyridin-3-yl or N-pyrazin-2-yl carboxamides
The present invention relates to compounds of formula I, wherein A, R1 to R7 are defined in the description, and to pharmaceutically acceptable salts thereof. The present invention also relates to the manufacture of such compounds or their pharmaceutically acceptable salts, pharmaceutical compositions containing them and their use as medicaments for the treatment and/or prophylaxis of diseases which can be treated with HDL-cholesterol raising agents, such as dyslipidemia, atherosclerosis and cardiovascular diseases.
US08410104B2 Pyridazines
The present invention is concerned with isoxazole-pyridazines of formula I, having affinity and selectivity for GABA A α5 receptor, their manufacture, pharmaceutical compositions containing them and their use as therapeutically active substances. The active compounds of the present invention are useful as cognitive enhancer or for the therapeutic and/or prophylactic treatment of cognitive disorders like Alzheimer's disease.
US08410103B2 (3S,11aR)-N-[2,4-difluorophenyl)methyl]-6-hydroxy-3-methyl-5,7-dioxo-2,3,5,7,11,11a-hexahydro[1,3]oxazolo[3,2-a]pyrido[1,2-d]pyrazine-8-carboxamide useful as anti-HIV agent
The present invention is directed to a substituted 2,3,5,7,11,11a-hexahydro[1,3]oxazolo[3,2 -a]pyrido[1,2-d]pyrazine-5,7-dione useful as an anti-HIV agent, which has the formula: as well as pharmaceutically acceptable salts thereof, compostions thereof, and methods of use thereof.
US08410096B2 Antitumor agent, kit and method of treating cancer
Disclosed are an antitumor preparation comprising a combination of (1) a combination drug of tegafur/gimeracil/oteracil potassium, (2) at least one ingredient selected from the group consisting of folinic acid and pharmacologically acceptable salts thereof, and (3) cis-oxalate(1R,2R-diaminocyclohexane)platinum(II); a kit comprising a combination of pharmaceutical compositions for treating cancer in a mammal, comprising: (a) a combination drug of tegafur/gimeracil/oteracil potassium in a therapeutically effective amount; (b) a composition containing at least one ingredient selected from the group consisting of folinic acid and pharmacologically acceptable salts thereof in an amount effective for enhancing antitumor effects, and (c) a composition containing cis-oxalate(1R,2R-diaminocyclohexane)platinum(II) in an amount effective for enhancing antitumor effects; and a method for treating cancer.
US08410093B2 Cycloalkyl substituted pyrimidinediamine compounds and their uses
The present disclosure provides 2,4-pyrimidinediamine compounds having antiproliferative activity, compositions comprising the compounds and methods of using the compounds to inhibit cellular proliferation and to treat proliferate diseases such as tumorigenic cancers.
US08410087B2 Indole compound
The purpose of the present invention is to provide a glucokinase activator useful as a pharmaceutical agent such as an agent for the prophylaxis or treatment of diabetes, obesity and the like. The present invention provides a glucokinase activator containing a compound represented by the formula (I): wherein R1 is a hydrogen atom or a halogen atom; R2 is a group represented by wherein each symbol is defined in the specification, or a salt thereof or a prodrug thereof.
US08410081B2 Treatment of cystic fibrosis
The present invention discloses a therapeutic target for the treatment of cystic fibrosis. It was found that inhibition of non-lysosomal glucosylceramidase (GBA2) sufficiently restores chloride current in cells from CF patients carrying the common delF508-CFTR mutation. With the catalytic center (4) of the enzyme positioned on top of the membrane bilayer face particularly potent inhibitors are found in deoxynojirimycin derivatives having a group that is capable of inserting in the membrane bilayer.
US08410080B1 2-methylene-vitamin D analogs and their uses
This invention discloses 2-methylene-vitamin D analogs, and specifically (20S)-1α,25 -dihydroxy-2-methylene-vitamin D3 as well as (5E)-(20S)-1α,25-dihydroxy-2 -methylene-vitamin D3 and (20R)-1α,25-dihydroxy-2-methylene-vitamin D3, as well as pharmaceutical uses therefor. These compounds exhibit relatively high binding activity and pronounced activity in arresting the proliferation of undifferentiated cells and inducing their differentiation to the monocyte thus evidencing use as an anti-cancer agent especially for the treatment or prevention of osteosarcoma, leukemia, colon cancer, breast cancer, skin cancer or prostate cancer. These compounds also have relatively high calcemic activities evidencing use in the treatment of bone diseases.
US08410077B2 Sulfoalkyl ether cyclodextrin compositions
SAE-CD compositions are provided, along with methods of making and using the same. The SAE-CD compositions comprise a sulfoalkyl ether cyclodextrin having an absorption of less than 0.5 A.U. due to a drug-degrading agent, as determined by UV/vis spectrophotometry at a wavelength of 245 nm to 270 nm for an aqueous solution containing 300 mg of the SAE-CD composition per mL of solution in a cell having a 1 cm path length.
US08410073B2 Methods and compositions for prevention or treatment of RSV infection
Methods and compositions are provided for the prevention or treatment of RSV infection in a human. The methods include administering one or more doses of a composition comprising an siRNA. The dose can be formulated for topical or parenteral administration. Topical administration includes administration as a nasal spray, or by inhalation of respirable particles or droplets. The siRNA comprises a sense strand of ALN-RSV01 and an antisense strand of ALN-RSV01.
US08410071B2 Potent LNA oligonucleotides for the inhibition of HIF-1A expression
The present disclosure relates to an LNA oligonucleotide consisting of a sequence selected from the group consisting of 5′-(Tx)GxGxcsasasgscsastscscsTxGxT-3′ and 5′-(Gx)TxTxascstsgscscststscsTxTxA-3′, wherein capital letters designate a beta-D-oxy-LNA nucleotide analogue, small letters designate a 2-deoxynucleotide, underline designates either a beta-D-oxy-LNA nucleotide analogue or a 2-deoxynucleotide, subscript “s” designates a phosphorothioate link between neighboring nucleotides/LNA nucleotide analogues, and subscript “x” designates either a phosphorothioate link or a phosphorodiester link between neighboring nucleotides/LNA nucleotide analogues, and wherein the sequence is optionally extended by up to five 2-deoxynucleotide units. The LNA oligonucleotides are useful for modulating the expression of hypoxia-inducible factor-1a (HIF-1a), e.g. in the treatment of cancer diseases, inhibiting angiogenesis, inducing apoptosis, preventing cellular proliferation, or treating an angiogenic disease, e.g. diabetic retinopathy, macular degeneration (ARMD), psoriasis, rheumatoid arthritis and other inflammatory diseases.
US08410068B2 Compounds for the treatment or alleviation of edema, and methods for their use
Isolated and substantially purified oligonucleotide compounds have been shown to be effective in reducing swelling and edema. Novel methods and substances are presented for the prevention, alleviation or treatment of edema of various aetiology.
US08410063B2 N-acetyl mannosamine as a therapeutic agent
The invention relates to compositions and methods for treating kidney and muscle dysfunction that involves use of therapeutic amounts of N-acetyl mannosamine.
US08410062B2 Collagen peptide, dipeptide and malady inhibitor
A problem that the present invention is to solve is to provide: a main body of a peptide molecule which is effective for inhibition of various maladies such as osteoporosis, osteoarthritis and pressure ulcer, particularly, a dipeptide which is easy to absorb into a body in an intestine; a collagen peptide which comprises the dipeptide as an essential dipeptide; and a malady inhibitor which comprises the dipeptide as an essential effective component. As a means of solving such a problem, a collagen peptide according to the present invention is characterized by comprising a dipeptide having a structure of Hyp-Gly as an essential dipeptide. A dipeptide according to the present invention is characterized by having a structure of Hyp-Gly. A malady inhibitor according to the present invention is characterized by comprising a dipeptide having a structure of Hyp-Gly as an essential effective component.
US08410061B2 Functional antagonists of hedgehog activity
Variants of hedgehog protein that contain N-terminal modifications are described that can block hedgehog function; thus allowing these variants to serve as functional antagonists. These peptides have a primary amino acid sequence lacking the ability to elicit a hedgehog-dependent response in C3H 10T1/2 cells but having the ability to bind to the hedgehog receptor, patched-1. Methods for producing such functional antagonists and methods of using the functional antagonists are also described.
US08410053B2 Methods for treating autoimmune disorders, and reagents related thereto
The invention generally relates to improved methods for treatment or prophylaxis in animal subjects (including humans) of autoimmune disorders including Type I diabetes, septic shock, multiple sclerosis, inflammatory bowel disease (IBD) and Crohn's disease.
US08410052B2 Oral administration of a calcitonin
The invention is directed to a method of administering pharmaceutical compositions comprising peptide drugs such as a calcitonin in combination with one or more oral delivery agents, together with an amount of a liquid, and method of treatment of disorders responsive to the action of peptide drugs such as a calcitonin employing such method of administration so as to enhance the oral bioavailability of a calcitonin. The methods of the invention increase the oral absorption and systemic bioavailability of peptide drugs, such as a calcitonin.
US08410051B2 FGF21 mutants and uses thereof
The invention provides nucleic acid molecules encoding FGF21 mutant polypeptides, FGF21 mutant polypeptides, pharmaceutical compositions comprising FGF21 mutant polypeptides, and methods for treating metabolic disorders using such nucleic acids, polypeptides, or pharmaceutical compositions.
US08410043B2 Stabilized activin IIB receptor polypeptides and uses thereof
The present invention provides stabilized activin IIB receptor polypeptides and proteins capable of binding and inhibiting the activities of activin A, myostatin, or GDF-11. The present invention also provides polynucleotides, vectors and host cells capable of producing the stabilized polypeptides and proteins. Compositions and methods for treating muscle-wasting diseases and metabolic disorders are also provided.
US08410041B2 Advanced moisture management laundry additive for providing soft hand, moisture transport and antistatic protection for polyester, polyester/spandex polyester/cotton and cotton fabrics
The present invention relates to a composition that, when incorporated into various steps of household and/or commercial laundering cycles provides highly durable treatment improving softness, moisture absorption and transport as well as antistatic characteristics of polyester, polyester/spandex polyester/cotton and cotton fabrics and corresponding articles made from these fabrics thereof.
US08410037B2 Conditioning composition for hair comprising an alkyl glyceryl ether and quaternized silicone
The present invention is related to aqueous conditioning composition for hair comprising at least one alkyl glyceryl ether and at least one silicone compound with at least one quaternary ammonium group in its molecule. Conditioning composition of the present invention can be in the form of a shampoo, cleansing—conditioning composition, or in the form of a conditioner used after washing hair with cleansing compositions. It has surprisingly been found out that a composition comprising at least one alkyl glyceryl ether and at least one silicone compound with at least one quaternary ammonium group in its molecule gives hair shine, volume and body and hair treated with such a composition looks attractive and has its natural excellent shine, volume and body, elasticity, smoothness and it is easily manageable. Accordingly, present invention is on a conditioning composition for hair comprising at least one alkyl glyceryl ether and at least one silicone compound with at least one quaternary ammonium group in its molecule.
US08410036B2 Composition for permanent or semipermanent tinting of keratin fibers with oil-in-glycol lamellar gel
The present application is directed to an oil-in-glycol lamellar gel, which comprises (a) at least one glycol, (b) at least one fatty alcohol, (c) at least one cationic surfactant, (d) at least one non-ionic surfactant and (e) at least one amino acid, for application as an addictive for permanent or semi-permanent keratin fiber color products, being the said lamellar gel able to improve dispersion of colorant agents in the color composition and the distribution, diffusion, interaction and maintenance of the colorant agents in the keratin fibers, which results in greater color vitality and retardation of the discoloring process.
US08410033B2 Preparation of diester-based biolubricants from monoesters of fatty acids and olefin-derived vicinal diols
The present invention is generally directed to methods of making diester-based (bio)lubricant compositions, wherein such diester-based lubricant compositions generally comprise diester species prepared by reacting vicinal diol species with monoester(s) of one or more fatty acids. In some embodiments, such methods for making such diester-based lubricants utilize one or more biomass precursor species (e.g., monoesters of fatty acids derived from crop oils and/or other source of triglyceride species such as algae). In some embodiments, such diester-based lubricants are derived from Fischer-Tropsch (FT) olefins, typically alpha (α)-olefins.
US08410032B1 Multi-vehicle automatic transmission fluid
A lubricant composition, a multi-vehicle transmission fluid, and a method for making a transmission fluid. The lubricant composition includes a) a base oil; b) 2,5-dimercapto-1,3,4-thiadiazole (DMTD), a derivative of DMTD, or mixtures thereof; and c) a friction modifier. The friction modifier is made by reacting an olefin containing at least 40% by weight C10-C36 vinylidene olefin with maleic acid, anhydride, or ester to provide a first reaction product, and aminating the first reaction product with an effective amount of a compound containing basic nitrogen to provide the friction modifier. The C10-C36 vinylidene olefin is represented by the following formula: wherein Rc and Rd are independently a (C3-C15) alkyl, cycloalkyl or cycloalkenyl.
US08410031B2 Method for preparing an imidized polymer
A process is provided for preparing an imidized polymer in a mixing or kneading device, by a reaction in the presence of an acid of a mixture containing a polymer having anhydride groups or derivatives thereof and an aromatic polyamine compound. A solid multifunctional viscosity modifier is also provided which includes a polymer having between 0.1 and 10 functional groups per 1000 C-atoms. The functional groups include aromatic amine based imide groups with a ratio of imide groups to the functional groups being more than 0.85.
US08410025B2 Stabilized herbicidal composition
A stabilized herbicidal composition, comprising a fenoxaprop ester herbicide, a salt of 2,4-D, a salt of MCPP-P and a salt of Dicamba, which may also optionally contain additional stabilizers such as triethylamine. Also disclosed is a stabilized herbicidal composition comprising a fenoxaprop ester herbicide in combination with a bromoxynil mixed ester herbicide. The stabilized herbicidal compositions of the present invention may also contain one or more surfactants and/or safeners.
US08410024B2 Use of maleimide salts to control phytopathogenic fungi
The present invention relates to the use of new and known maleimide salts for controlling phytopathogenic fungi, and also to methods for controlling phytopathogenic fungi in crop protection, in the household and hygiene sectors and in materials protection, and also to crop protection compositions comprising these maleimide salts.
US08410022B2 Glyphosate salt herbicidal composition
A herbicidal composition comprises in aqueous solution a mixture of salts of glyphosate at a total glyphosate a.e. concentration not less than about 360 g/l, wherein (a) said glyphosate is in anionic form accompanied by low molecular weight non-amphiphilic cations in a total molar amount of about 100% to about 120% of the molar amount of said glyphosate; (b) said cations comprise potassium and propylammonium (e.g., isopropylammonium) cations in a mole ratio of about 70:30 to about 90:10; and (c) said potassium and propylammonium cations together constitute about 90 to 100 molar percent of all of said low molecular weight non-amphiphilic cations in the composition.
US08410019B2 Modifying agent for coating composition for producing protective layer in thermosensitive recording medium, coating composition for protective layer in thermosensitive recording medium, and thermosensitive recording medium using the same
A modifying agent for a coating composition for producing a protective layer in a thermosensitive recording medium, wherein the modifying agent contains a polyurethane resin (A) having the structure represented by the following general formula (I) and a hydrophilic group, and an aqueous medium. (in the general formula (I), R1 and R2 represent individually an alkyl group, and m and n represent individually an integer of 1 or greater.)
US08410018B2 Iron-comprising heterogeneous catalyst and process for preparing olefins by reaction of carbon monoxide with hydrogen
Iron-comprising heterogeneous catalyst and a process for producing it, which comprises the steps of thermal decomposition of gaseous iron pentacarbonyl to give carbonyl iron powder having spherical primary particles, treatment of carbonyl iron powder with hydrogen, resulting in the metallic spherical primary particles at least partially forming agglomerates, contacting the agglomerates with iron pentacarbonyl, and thermal decomposition of the iron pentacarbonyl to give at least predominantly pore-free and void-free secondary particles.
US08410014B2 Method for producing catalysts and their use for the gas phase oxidation of olefins
Especially physically stable metal oxide catalyst supports are prepared by suspending a metal oxide in a continuous phase, activating by fine dispersion, coagulation to a viscoelastic mass, shaping, drying, and calcining. The catalyst support thus prepared may be treated with catalytic agents to produce supported catalysts for olefin oxidation.
US08410013B2 Catalyst for treating exhaust gas
Provided is a catalyst for treating exhaust gas capable of reducing the amount of a highly corrosive mercury-chlorinating agent to be added while keeping the mercury oxidation efficiency high in an exhaust gas treatment. By the catalyst for treating exhaust gas, nitrogen oxide in the exhaust gas is removed upon contact with ammonia serving as a reducing agent, and mercury is oxidized using a halogen serving as an oxidant. The catalyst includes: TiO2 as a support; an oxide of at least one selected from the group consisting of V, W and Mo, which is supported as an active component on the support; and at least one selected from the group consisting of Bi, P, and compounds containing Bi and/or P, which is supported as a co-catalyst component on the support.
US08410006B2 Composite filter media with high surface area fibers
The present invention is directed to a high surface area fibers and an improved filter composite media made from the same. More specifically, the composite media preferably comprises a winged-fiber layer having high surface area fibers for increased absorption and strength and a meltblown layer for additional filtration. In one preferred embodiment the high surface area fibers have a middle region with a plurality of projections that define a plurality of channels, which increases the surface area of the fiber. In one preferred embodiment, the high surface area fiber has a specific surface area of about 140,000 cm2/g or higher and a denier of about 1.0 to about 2.0. The high surface area fiber of the present invention is made using a bicomponent extrusion process using a thermoplastic polymer and a dissolvable sheath.
US08410002B2 Semiconductor device and manufacturing method thereof
An object is to provide a semiconductor device with a novel structure and favorable characteristics. A semiconductor device includes an oxide semiconductor layer, a source electrode and a drain electrode electrically connected to the oxide semiconductor layer, a gate insulating layer covering the oxide semiconductor layer, the source electrode, and the drain electrode, and a gate electrode over the gate insulating layer. The source electrode and the drain electrode include an oxide region formed by oxidizing a side surface thereof. Note that the oxide region of the source electrode and the drain electrode is preferably formed by plasma treatment with a high frequency power of 300 MHz to 300 GHz and a mixed gas of oxygen and argon.
US08410001B2 Method of manufacturing semiconductor device, method of processing substrate, and substrate processing apparatus
An excellent type of a film is realized by modifying conventional types of films. A carbonitride film of a predetermined thickness is formed on a substrate by performing, a predetermined number of times, a cycle including the steps of: supplying a source gas into a process vessel accommodating the substrate under a condition where a CVD reaction is caused, and forming a first layer including an element on the substrate; supplying a carbon-containing gas into the process vessel to form a layer including carbon on the first layer, and forming a second layer including the element and the carbon; supplying the source gas into the process vessel under a condition where a CVD reaction is caused to additionally form a layer including the element on the second layer, and forming a third layer including the element and the carbon; and supplying a nitrogen-containing gas into the process vessel to nitride the third layer, and forming a carbonitride layer serving as a fourth layer including the element, the carbon, and nitrogen.
US08410000B2 Method for producing photovoltaic cell
The method for producing a photovoltaic cell includes applying, on a partial region of one surface side of a semiconductor substrate, a first p-type diffusion layer forming composition including a p-type impurity-containing glass powder and a dispersion medium; applying, on at least a region other than the partial region on the surface of the semiconductor substrate, a second p-type diffusion layer forming composition which includes a p-type impurity-containing glass powder and a dispersion medium and in which a concentration of the p-type impurity is lower than that of the first p-type diffusion layer forming composition, where the first p-type diffusion layer forming composition is applied; heat-treating the semiconductor substrate on which the first p-type diffusion layer forming composition and the second p-type diffusion layer forming composition are applied to form a p-type diffusion layer; and forming an electrode on the partial region.
US08409993B2 Method and system for controlling copper chemical mechanical polish uniformity
A system and method for controlling resistivity uniformity in a Copper trench structure by controlling the CMP process is provided. A preferred embodiment comprises a system and a method in which a plurality of CMP process recipes may be created comprising at least a slurry arm position. A set of metrological data for at least one layer of the semiconductor substrate may be estimated, and an optimum CMP process recipe may be selected based on the set of metrological data. The optimum CMP process recipe may be implemented on the semiconductor substrate.
US08409987B2 Method for depositing thin tungsten film with low resistivity and robust micro-adhesion characteristics
Methods of forming low resistivity tungsten films with good uniformity and good adhesion to the underlying layer are provided. The methods involve forming a tungsten nucleation layer using a pulsed nucleation layer process at low temperature and then treating the deposited nucleation layer prior to depositing the bulk tungsten fill. The treatment operation lowers resistivity of the deposited tungsten film. In certain embodiments, the depositing the nucleation layer involves a boron-based chemistry in the absence of hydrogen. Also in certain embodiments, the treatment operations involve exposing the nucleation layer to alternating cycles of a reducing agent and a tungsten-containing precursor. The methods are useful for depositing films in high aspect ratio and/or narrow features. The films exhibit low resistivity at narrow line widths and excellent step coverage.
US08409982B2 Method of forming solid blind vias through the dielectric coating on high density interconnect (HDI) substrate materials
A method includes forming a first substrate by (a) applying an electrodepositable dielectric coating onto a conductive surface; (b) curing the dielectric coating; (c) depositing an adhesion layer and a seed layer onto the dielectric coating; (d) applying a layer of a first removable material to the seed layer; (e) forming openings in the first removable material to expose areas of the seed layer; (f) electroplating a first conductive material to the exposed areas of the seed layer; (g) applying a layer of a second removable material; (h) forming openings in the second removable material to expose areas of the first conductive material; (i) plating a second conductive material to the exposed areas of the first conductive material; (j) removing the first and second removable materials; (k) removing unplated portions of the seed layer; repeating steps (a) through (k) to form a second substrate; and laminating the first and second substrates together with a layer of dielectric material between the first and second substrates to form at least one interconnect between the first and second substrates.
US08409981B2 Semiconductor package with a metal post and manufacturing method thereof
Disclosed are a semiconductor package and a manufacturing method thereof. The semiconductor package can include a semiconductor substrate, having one surface on which a conductive pad is formed; an insulating layer, being formed on one surface of the semiconductor substrate; a metal post, penetrating through the conductive pad, the semiconductor substrate, and the insulating layer; and an outer-layer circuit, being electrically connected to the metal post. With the present invention, it can become unnecessary to form an additional via for electrically connecting both surfaces of the semiconductor substrate, thereby simplifying the manufacturing process, reducing the manufacturing cost, and improving the coupling reliability.
US08409978B2 Semiconductor device and method of forming vertically offset bond on trace interconnect structure on leadframe
A semiconductor device has a vertically offset BOT interconnect structure. The vertical offset is achieved with a leadframe having a plurality of lead fingers around a die paddle. A first conductive layer is formed over the lead fingers. A second conductive layer is formed over the lead fingers. Each second conductive layer is positioned adjacent to the first conductive layer and each first conductive layer is positioned adjacent to the second conductive layer. The second conductive layer has a height greater than a height of the first conductive layer. The first and second conductive layers can have a side-by-side arrangement or staggered arrangement. Bumps are formed over the first and second conductive layers. Bond wires are electrically connected to the bumps. A semiconductor die is mounted over the die paddle of the leadframe and electrically connected to the bond wires and BOT interconnect structure.
US08409976B2 Solar cell structures, photovoltaic panels and corresponding processes
Photovoltaic modules comprise solar cells having doped domains of opposite polarities along the rear side of the cells. The doped domains can be located within openings through a dielectric passivation layer. In some embodiments, the solar cells are formed from thin silicon foils. Doped domains can be formed by printing inks along the rear surface of the semiconducting sheets. The dopant inks can comprise nanoparticles having the desired dopant.
US08409973B2 Separation apparatus, separation method, and method for manufacturing semiconductor element
Objects are to reduce the number of steps in a process for separating a substrate and a semiconductor element, to provide a separation apparatus capable of reducing the number of steps, to suppress manufacturing cost by reducing the number of steps in a separation process, and to improve productivity in manufacturing semiconductor elements. A separation apparatus including a frame body, a porous body having a chamfered, rounded corner portion, a suction unit configured to create suction in the porous body and the frame body, and a jig which includes a unit adopted to press down part of an object to be separated and a unit adopted to lift another part of the object to be separated, and also a separation method and a method for manufacturing a semiconductor element by using the separation apparatus, are provided.
US08409971B2 Integrated multicomponent device in a semiconducting die
An electronic device with integrated discrete components, including a wafer including cavities that can receive the components, an active face of the components being in a same plane as a face of the receiving wafer, and a material for laterally coating the components in the cavities.
US08409969B2 Optical device wafer processing method
An optical device wafer has a device area where a plurality of optical devices are formed on the front side of a sapphire substrate, and a peripheral marginal area surrounding the device area. The device area projects from the peripheral marginal area. A break start point is formed on the front side of the sapphire substrate by applying a laser beam along the boundary between the device area and the peripheral marginal area. A protective member is attached to the front side of the optical device wafer. The optical device wafer is held on a chuck table of a grinding apparatus so that the protective member comes into contact with a holding surface of the chuck table. The back side of the sapphire substrate is ground to reduce the thickness thereof to a predetermined thickness.
US08409968B2 Method of cutting semiconductor substrate via modified region formation and subsequent sheet expansion
Multiphoton absorption is generated, so as to form a part which is intended to be cut 9 due to a molten processed region 13 within a silicon wafer 11, and then an adhesive sheet 20 bonded to the silicon wafer 11 is expanded. This cuts the silicon wafer 11 along the part which is intended to be cut 9 with a high precision into semiconductor chips 25. Here, opposing cut sections 25a, 25a of neighboring semiconductor chips 25, 25 are separated from each other from their close contact state, whereby a die-bonding resin layer 23 is also cut along the part which is intended to be cut 9. Therefore, the silicon wafer 11 and die-bonding resin layer 23 can be cut much more efficiently than in the case where the silicon wafer 11 and die-bonding resin layer 23 are cut with a blade without cutting a base 21.
US08409967B2 Method for manufacturing semiconductor chips from a semiconductor wafer
A method for manufacturing semiconductor chips from a semiconductor wafer, including the steps of: fastening, on a first support frame, a second support frame having outer dimensions smaller than the outer dimensions of the first frame and greater than the inner dimensions of the first frame; arranging the wafer on a surface of a film stretched on the second frame; carrying out wafer processing operations by using equipment capable of receiving the first frame; separating the second frame from the first frame and removing the first frame; and carrying out wafer processing operations by using equipment capable of receiving the second frame.
US08409964B2 Shallow trench isolation with improved structure and method of forming
A shallow trench isolation (STI) structure and methods of forming a STI structure are disclosed. An embodiment is a method for forming a semiconductor structure. The method includes forming a recess in a semiconductor substrate; forming a first material on sidewalls of the recess; forming a widened recessed portion through a bottom surface of the recess; removing the first material from the sidewalls of the recess; and forming a dielectric material in the recess and the widened recessed portion. The bottom surface of the recess is exposed through the first material, and the bottom surface of the recess has a first width. The widened recessed portion has a second width. The second width is greater than the first width.
US08409962B2 Manufacturing method of copper interconnection structure with MIM capacitor
present invention discloses a manufacturing method for a copper interconnection structure with MIM capacitor. The method firstly makes a copper conductive pattern in a copper interconnection structure and a copper through hole bolt connected with the copper conductive pattern; etch away an insulation layer around the copper through hole bolt and deposit a etch stop layer, so as to expose the top and side surface of the copper through hole bolt and part of the top surface of the copper conductive pattern; deposit a dielectric layer on the obtained structure and fill a protection material in the recession area of the obtained structure; etch a trench for receiving other copper conductive patterns; remove the protection material; plate copper in the recession area, and plate copper in the trench, so as to obtain a copper interconnection structure with MIM capacitor.
US08409959B2 Vertically base-connected bipolar transistor
Methods, devices, and systems for using and forming vertically base-connected bipolar transistors have been shown. The vertically base-connected bipolar transistors in the embodiments of the present disclosure are formed with a CMOS fabrication technique that decreases the transistor size while maintaining the high performance characteristics of a bipolar transistor.
US08409957B2 Graphene devices and silicon field effect transistors in 3D hybrid integrated circuits
A three dimensional integrated circuit includes a silicon substrate, a first source region disposed on the substrate, a first drain region disposed on the substrate, a first gate stack portion disposed on the substrate, a first dielectric layer disposed on the first source region, the first drain region, the first gate stack portion, and the substrate, a second dielectric layer formed on the first dielectric layer, a second source region disposed on the second dielectric layer, a second drain region disposed on the second dielectric layer, and a second gate stack portion disposed on the second dielectric layer, the second gate stack portion including a graphene layer.
US08409956B1 Methods of forming integrated circuit devices using self-aligned contact formation techniques
Methods of forming integrated circuit devices include forming first and second gate electrodes at side-by-side locations on a substrate and forming first and second sidewall spacers on sidewalls of the first gate electrode and the second gate electrode, respectively. The first and second gate electrodes are covered with a first electrically insulating layer of a first material. A second electrically insulating layer of a second material is deposited on the first electrically insulating layer. The second electrically insulating layer is patterned to define a first opening therein that exposes an underlying first portion of the first electrically insulating layer.
US08409953B2 Method of manufacturing a semiconductor device
In a semiconductor device and associated methods, the semiconductor device includes a substrate, an insulation layer on the substrate, a conductive structure on the insulation layer, the conductive structure including at least one metal silicide film pattern, a semiconductor pattern on the conductive structure, the semiconductor pattern protruding upwardly from the conductive structure, a gate electrode at least partially enclosing the semiconductor pattern, the gate electrode being spaced apart from the conductive structure, a first impurity region at a lower portion of the semiconductor pattern, and a second impurity region at an upper portion of the semiconductor pattern.
US08409951B2 Metal control gate formation in non-volatile storage
Methods for fabricating control gates in non-volatile storage are disclosed. When forming stacks for floating gate memory cells and transistor control gates, a sacrificial material may be formed at the top of the stacks. After insulation is formed between the stacks, the sacrificial material may be removed to reveal openings. In some embodiments, cutouts are then formed in regions in which control gates of transistors are to be formed. Metal is then formed in the openings, which may include the cutout regions. Therefore, floating gate memory cells having at least partially metal control gates and transistors having at least partially metal control gates may be formed in the same process. A barrier layer may be formed prior to depositing the metal in order to prevent silicidation of polysilicon in the control gates.
US08409949B2 Non-volatile semiconductor memory device and method of manufacturing the same
Provided is a nonvolatile semiconductor memory device highly integrated and highly reliable. A plurality of memory cells are formed in a plurality of active regions sectioned by a plurality of isolations (silicon oxide films) extending in the Y direction and deeper than a well (p type semiconductor region). In each memory cell, a contact is provided in the well (p type semiconductor region) so as to penetrate through a source diffusion layer (n+ type semiconductor region), and the contact that electrically connects bit lines (metal wirings) and the source diffusion layer (n+ type semiconductor region) is also electrically connected to the well (p type semiconductor region).
US08409948B2 Methods of forming transistors, and methods of forming memory arrays
Some embodiments include methods of forming vertical transistors. A construction may have a plurality of spaced apart fins extending upwardly from a semiconductor substrate. Each of the fins may have vertical transistor pillars, and each of the vertical transistor pillars may have a bottom source/drain region location, a channel region location over the bottom source/drain region location, and a top source/drain region location over the channel region location. Electrically conductive gate material may be formed along the fins while using oxide within spaces along the bottoms of the fins to offset the electrically conductive gate material to be above the bottom source/drain region locations of the vertical transistor pillars. The oxide may be an oxide which etches at a rate of at least about 100 Å/minute with dilute HF at room temperature. In some embodiments the oxide may be removed after the electrically conductive gate material is formed.
US08409942B2 Replacement gate approach based on a reverse offset spacer applied prior to work function metal deposition
In a replacement gate approach, a spacer may be formed in the gate opening after the removal of the placeholder material, thereby providing a superior cross-sectional shape upon forming any electrode metals in the gate opening. Moreover, the spacer may be used for reducing the gate length, while not requiring more complex gate patterning strategies.
US08409939B2 Semiconductor device and method for fabricating the same
A method for fabricating a semiconductor device includes: forming a fin-type semiconductor region on a substrate; and introducing an n-type impurity into at least a side of the fin-type semiconductor region by a plasma doping process, thereby forming an n-type impurity region in the side of the fin-type semiconductor region. In the introducing the n-type impurity, when a source power in the plasma doping process is denoted by a character Y [W], the supply of a gas containing the n-type impurity per unit time and per unit volume is set greater than or equal to 5.1×10−8/((1.72.51/24.51)×(Y/500)) [mol/(min·L·sec)], and the supply of a diluent gas per unit time and per unit volume is set greater than or equal to 1.7×10−4/((202.51/24.51)×(Y/500)) [mol/(min·L·sec)].
US08409936B2 Method for manufacturing a semiconductor device by forming portions thereof at the same time
A device and a method for manufacturing the same in which with device includes a single crystal semiconductor substrate and an SOI substrate separated from the single crystal semiconductor substrate by a thin buried insulating film and having a thin single crystal semiconductor thin film (SOI layer) in which well diffusion layer regions, drain regions, gate insulating films, and gate electrodes of the SOI-type MISFET and the bulk-type MISFET are formed in the same steps. The bulk-type MISFET and the SOI-type MISFET are formed on the same substrate, so that board area is reduced and a simple process can be realized by making manufacturing steps of the SOI-type MISFET and the bulk-type MISFET common.
US08409934B2 Methods for forming materials using micro-heaters and electronic devices including such materials
Nano-sized materials and/or polysilicon are formed using heat generated from a micro-heater, the micro-heater may include a substrate, a heating element unit formed on the substrate, and a support structure formed between the substrate and the heating element unit. Two or more of the heating element units may be connected in series.
US08409933B2 Methods of forming conductive contacts to source/drain regions and methods of forming local interconnects
The invention comprises methods of forming a conductive contact to a source/drain region of a field effect transistor, and methods of forming local interconnects. In one implementation, a method of forming a conductive contact to a source/drain region of a field effect transistor includes providing gate dielectric material intermediate a transistor gate and a channel region of a field effect transistor. At least some of the gate dielectric material extends to be received over at least one source/drain region of the field effect transistor. The gate dielectric material received over the one source/drain region is exposed to conditions effective to change it from being electrically insulative to being electrically conductive and in conductive contact with the one source/drain region. Other aspects and implementations are contemplated.
US08409924B2 Flexible interconnect pattern on semiconductor package
An embodiment of the present invention is a technique to fabricate a metal interconnect. A first metal trace is printed on a die attached to a substrate or a cavity of a heat spreader in a package to electrically connect the first metal trace to a power contact in the substrate. A device is mounted on the first metal trace. The device receives power from the substrate when the package is powered.
US08409923B2 Integrated circuit packaging system with underfill and method of manufacture thereof
A method of manufacture of an integrated circuit packaging system includes: providing a substrate with a projection formed along a perimeter of a first surface of the substrate; mounting an integrated circuit over the first surface; forming a protruding interconnect over the first surface between the projection and the integrated circuit; and forming an underfill between the integrated circuit and the projection with a uniform height, the uniform height of the underfill less than a height of the projection.
US08409921B2 Integrated circuit package system including honeycomb molding
A method of manufacture of an integrated circuit package system includes: providing a substrate with a top surface; configuring the top surface to include electrical contacts and an integrated circuit; providing a structure over the substrate with only a honeycomb meshwork of posts contacting the top surface of the substrate; and depositing a material to prevent warpage of the substrate on the top surface of the substrate and over the integrated circuit, the material patterned to have discrete hollow conduits that expose the electrical contacts.
US08409918B2 Semiconductor device and method of forming pre-molded substrate to reduce warpage during die mounting
A semiconductor device has a substrate with a plurality of conductive vias formed through the substrate and conductive layer formed over the substrate. A first encapsulant is deposited over the substrate outside a die attach area of the substrate. The first encapsulant surrounds each die attach area over the substrate and the die attach area is devoid of the first encapsulant. A channel connecting adjacent die attach areas is also devoid of the first encapsulant. A first semiconductor die is mounted over the substrate within the die attach area after forming the first encapsulant. A second semiconductor die is mounted over the first die within the die attach area. An underfill material can be deposited under the first and second die. A second encapsulant is deposited over the first and second die and first encapsulant. The first encapsulant reduces warpage of the substrate during die mounting.
US08409913B2 Semiconductor device and method for producing same
A semiconductor device includes a semiconductor substrate having at least one surface provided with a semiconductor element, wherein the semiconductor substrate includes a region of a first conductivity type, the region being formed in a surface layer portion of the semiconductor substrate; a first diffusion region of a second conductivity type, the first diffusion region having a first impurity concentration and being formed in the surface layer portion, and a pn junction being formed between the first diffusion region and the region of the first conductivity type; and a first metal silicide film formed on part of a portion of the surface corresponding to the first diffusion region.
US08409911B2 Methods for metallization of solar cells
A method for metallization of solar cells is disclosed. The method includes providing a superstrate, such as a sheet of polymer film, to be used as a transport during metallization of solar cells. The method includes attaching the back sides of the solar cells to the sheet of polymer film. The method also includes forming contact holes through the sheet of polymer film to expose doped regions of the solar cells. The method also includes forming metals in the contact holes to electrically connect to the exposed doped regions of the solar cells. The method further includes electroplating the metals to form metal contacts of the solar cell. Subsequently, the method also includes separating the solar cells from other solar cells that were metallized while supported by the same sheet of polymer film to form strings of solar cells or individual solar cells.
US08409907B2 Method for manufacturing information aquiring semiconductor device
A method for manufacturing a semiconductor device for detecting a physical amount distribution, the semiconductor device comprising unit components arrayed in a predetermined order, the unit components each including a unit signal generation portion for detecting an electromagnetic wave and outputting the corresponding unit signal. A diffraction grating is provided on the incident light side of a spectral image sensor, the diffraction grating including scatterers, slits, and scatterers disposed in that order. An electromagnetic wave is scattered by the scatterers to produce diffracted waves, and by using the fact that interference patterns between the diffracted waves change with wavelengths, signals are detected for respective wavelengths by photoelectric conversion elements in each photodiode group.
US08409903B2 Image sensor with improved color crosstalk
An image sensor comprises a substrate of a first conductivity type. First and second pixels are arrayed over the substrate. A potential barrier is formed in a region of the substrate corresponding to the first pixel but not in a region of the substrate corresponding to the second pixel. The second pixel is responsive to a color having a wavelength longer than the color to which the first pixel is responsive. The potential barrier is doped with dopants by a high energy ion implantation dopants or by an ion implantation or diffusion during epitaxial growth of the P-type epitaxial layer.
US08409899B2 Delamination and crack resistant image sensor structures and methods
A plurality of image sensor structures and a plurality of methods for fabricating the plurality of image sensor structures provide for inhibited cracking and delamination of a lens capping layer with respect to a planarizing layer within the plurality of image sensor structures. Particular image sensor structures and related methods include at least one dummy lens layer of different dimensions than active lens layer located over a circuitry portion of a substrate within the particular image sensor structures. Additional particular image sensor structures include at least one of an aperture within the planarizing layer and a sloped endwall of the planarizing layer located over a circuitry portion within the particular image sensor structures.
US08409898B1 Assembly system for photovoltaic packages
Assembly system for photovoltaic packages. According an embodiment, the present invention provides a system for assembling photovoltaic packages. The system includes a base plate member, which comprises a plurality of coupling elements. The plurality of coupling elements are characterized by a first length. The plurality of coupling elements is aligned according to a predetermined configuration. The plurality of coupling elements includes first and second coupling elements. The system also includes a top plate member, which includes a plurality of openings and a plurality of locator elements. The plurality of openings is characterized by a second length. The second length is greater than the first length. The openings and the locator elements are aligned according to the first predetermined configurations. The top plate member is disengageably coupled to the base plate member by the coupling elements and the openings.
US08409895B2 Gallium nitride-based LED fabrication with PVD-formed aluminum nitride buffer layer
Fabrication of gallium nitride-based light emitting diodes (LEDs) with physical vapor deposition (PVD) formed aluminum nitride buffer layers is described.
US08409893B2 Semiconductor light-emitting element, fabrication method thereof, convex part formed on backing, and convex part formation method for backing
A convex part formation method of forming a convex part in parallel with a <110> direction of a backing on the backing having a {100} face as the top surface thereof, includes: (a) forming a mask layer in parallel with the <110> direction on the backing; (b) etch the backing so as to form a convex-part upper layer whose sectional shape on a cutting plane corresponding to a {110} face is an isosceles trapezoid, the base of which is longer than the upper side thereof, and the side surface of which has an inclination of θU; and (c) further etching the backing so as to form a convex-part lower layer whose sectional shape on the cutting plane corresponding to the {110} face is an isosceles trapezoid, the base of which is longer than the upper side thereof, and the side surface of which has an inclination of θD (where θD≠θU).
US08409890B2 Semiconductor device and manufacturing method thereof
A structure capable of changing the characteristic value of an element after the formation of the element in order to prevent the increase of the manufacturing cost and delay in the delivery of a product. A plurality of diodes is connected in series. Then, a part of the plurality of diodes is short-circuited by a wiring. In specific, a diode and a wiring are connected in parallel, whereby a current flows preferentially into the wiring, so that the diode can be regarded as nonexistent. Then, the wiring is cut at a part of the wiring, thereby having the diode which is connected to the wiring in parallel before the cutting functioning.
US08409884B2 Process for producing organic electroluminescent panel
The process for producing an organic EL panel according to the present invention is a process for producing an organic electroluminescent panel by forming an organic electroluminescent element on an ultrathin glass plate by vacuum deposition method, including forming electrodes on the ultrathin glass plate, by temporarily fixing the ultrathin glass plate to a supporting plate via a double-sided adhesive tape having a thermal release adhesive layer formed at least on one face of the base material layer, containing heat-expandable microspheres that start expansion and/or foaming at temperature higher than the vacuum deposition temperature.
US08409881B2 Multi-project wafer and method of making same
A semiconductor wafer is fabricated. The wafer has a plurality of dies. The plurality of dies include at least operable dies of a first type and operable dies of a second type different from the first type. The dies of the second type are rendered inoperable, while keeping the dies of the first type operable. The wafer is provided with the operable dies of the first type and the inoperable dies of the second type on it, for testing of the dies of the first type.
US08409880B2 Method for use in making electronic devices having thin-film magnetic components
Disclosed herein is a method of forming electronic device having thin-film components by using trenches. One or more of thin-film components is formed by depositing a thin-film in the trench followed by processing the deposited thin-film to have the desired thickness.
US08409878B2 Detection and monitoring of liver damage
A method of detecting liver damage in a subject comprises measuring the level of caspase-3 generated cytokeratin-18 fragments in the bodily sample. The level of measuring the level of caspase-3 generated cytokeratin-18 fragments is then correlated with liver disease progression.
US08409877B2 Enzymatic signal generation and detection of binding complexes in stationary fluidic chip
An embodiment of the invention relates to a device for detecting an analyte in a sample. The device comprises a fluidic network and an integrated circuitry component. The fluidic network comprises a sample zone, a cleaning zone and a detection zone. The fluidic network contains a magnetic particle and/or a signal particle. A sample containing an analyte is introduced, and the analyte interacts with the magnetic particle and/or the signal particle through affinity agents. A microcoil array or a mechanically movable permanent magnet is functionally coupled to the fluidic network, which are activatable to generate a magnetic field within a portion of the fluidic network, and move the magnetic particle from the sample zone to the detection zone. A detection element is present which detects optical or electrical signals from the signal particle, thus indicating the presence of the analyte.
US08409872B2 Cartridge for automatic measurement and measuring method using it
A cartridge for use in measuring a component to be measured contained in a sample includes a diluting well for diluting a predetermined amount of the sample to a desired dilution, and a reaction well in which the component to be measured contained in the sample and a substance specifically reacting therewith are allowed to react. A diluting solution is filled in the diluting well in a predetermined amount to provide the desired dilution based on a type of the component to be measured when the predetermined amount of the sample is dispensed in the diluting well by a uniform operation.
US08409865B2 Methods and kits for the determination of the presence and quantity of vitamin D analogs in samples
Embodiments of the present invention are directed to methods and kits for determining the presence or absence, and the amount if present, of vitamin D analogs in samples. One embodiment of the present method for detecting the presence or absence of vitamin D analogs in a sample comprises the steps of adding an effective amount of a multiple charge cationic agent to the sample to form a cationic treated sample. The effective amount of a multiple charge cationic agent enhances the signal from vitamin D analogs upon analysis by mass spectroscopy.
US08409864B2 Ammonia sensor and system for use
An ammonia gas sensing device includes a housing defining a fluid flow path. The fluid flow path includes a fluid inlet, a fluid outlet, and an access port. A gas permeable/liquid impermeable membrane is mounted on and sealed against the housing at the access port such that the membrane is exposed to the fluid flow path but fluid is blocked from flowing outward of the access port around rather than through the membrane. An ammonia sensor is mounted on the housing at the access port in a position outward of the membrane. A system for using the ammonia sensing device includes the ammonia gas sensing device, a light source directed at the ammonia sensor, a photo detector to measure the light reflected off the ammonia sensor from the light source, and a controller for controlling the light source and optical sensor.
US08409853B2 Continuous process and apparatus for enzymatic treatment of lipids
A method and system for the enzymatic treatment of a lipid containing feedstock comprises contacting the feedstock with a processing aid, then causing the feedstock to pass at a substantially constant flow rate through a treatment system comprising a plurality of enzyme-containing fixed bed reactors connected to one another in series. The fixed bed reactors can be individually serviceable, the flow rate of the feedstock remaining substantially constant through the system when one of the fixed bed reactors is taken offline for servicing. In the most preferred embodiment, the processing aid is a substantially moisture-free silica. The processing aid can be placed in one or more of the fixed bed reactors, disposed above the enzyme in the reactor, or it can be in a pre-treatment system which can comprise one or more reactors.
US08409851B2 Bioactive carbon dioxide filter apparatus and method therefor
A bioactive filter is provided which comprises a transparent canister having gas permeable membranes as entry and exit ports. A source of carbon dioxide in gaseous form is allowed to enter the entry membrane and pass through a solution contained in the canister which supports a live colony of algae. The algae carries out photosynthesis thereby altering the carbon dioxide to oxygen and sugar. The oxygen is released through the exit port.
US08409846B2 Compositions, methods and devices for maintaining an organ
Compositions, methods, systems/devices and media are provided for maintaining a harvested organ in a functioning and viable state prior to implantation. The organ perfusion apparatus includes a preservation chamber for storing the organ during the preservation period. A perfusion circuit is provided having a first line for providing an oxygenated fluid to the organ, and a second line for carrying depleted fluid away from the organ. The perfusion apparatus also includes a device operably associated with the perfusion circuit for maintaining the organ at a substantially normothermic temperature.
US08409844B2 Lactic acid bacteria providing improved texture of fermented dairy products
A novel Streptococcus thermophilus (ST) bacterium that gives improved texture in e.g. a fermented milk dairy product.
US08409843B2 Multi plasmids system for the production of influenza virus
Vectors and methods for the production of influenza viruses suitable as recombinant influenza vaccines in cell culture are provided. Bi-directional expression vectors for use in a multi-plasmid influenza virus expression system are provided. Additionally, the invention provides methods of producing influenza viruses with enhanced ability to replicate in embryonated chicken eggs and/or cells (e.g., Vero and/or MDCK) and further provides influenza viruses with enhanced replication characteristics. In addition, the present invention includes an improved method of rescue, wherein animal cells (e.g., SF Vero cells) are electroporated with plasmids and vectors of the invention.
US08409837B2 Crystal structure of glutaminyl cyclase
A novel crystal structures of human and murine glutaminyl cyclase (QC, EC 2.3.2.5), methods of preparing the crystals, as well as the use of said crystal structures for identifying inhibitors of human and murine glutaminyl cyclase.
US08409824B2 Methionine sulfoxide antibodies
Antibodies specific for methionine sulfoxide residues on proteins are provided. The antibodies are prepared using methionine-rich zein proteins, which are oxidized, as antigens.
US08409823B2 Integrated process for the production of bio-oil from micro-organisms
The cultivation of heterotrophic and phototrophic micro-organisms is integrated for the production of bio-oil for biofuels, wherein the overall algal suspension produced is first thickened, with recirculation of the excess water to cultivation containers, and then thermally treated at a high temperature. After cooling, a bio-oil phase is recovered together with a suspension rich in soluble carbohydrates and proteins which forms a nutritional/energy source for heterotrophic micro-organisms.
US08409822B2 Composition of porous silica granules for delivering microorganisms
The present invention generally relates to compositions and methods of delivering substances in a dry mode. In one embodiment, the substance can be bacteria, enzymes, other microorganisms, or combinations thereof. The compositions that are in accordance with various embodiments of the present invention have varied uses, which can include delivering microorganisms to remove contaminates, such as oil, chemical, waste, or sewage, from soil, water, or air. In other embodiments, the substances can include liquid food, liquid food additives, liquid biotech agricultural ingredients, conventional liquid agricultural ingredients, liquid human wellness and dietary supplements, and liquid fragrances and beauty products.
US08409816B2 Diabetes-related biomarkers and methods of use thereof
The invention describes biomarkers which can be used to predict the likelihood that an individual will develop Diabetes. The biomarkers can also be used to screen large groups in order to identify individuals at risk of developing Diabetes.
US08409815B2 sCD40L and placental growth factor (PLGF) used as a biochemical marker combination in cardiovascular diseases
The invention relates to novel markers of vascular inflammation and combinations thereof as diagnostic and prognostic tools in patients with cardiovascular diseases. The markers also act as tools that facilitate the selection of active ingredients for the treatment of such diseases, and finally act as starting points for the treatment of cardiovascular diseases. Furthermore, the invention relates to the creation of an individual risk profile of negative events that are associated with the progression of arteriosclerosis.
US08409814B2 Sensor proteins and assay methods
The present invention relates to biosensors. In some embodiments, the biosensors are modified ligand binding molecules. In some embodiments, the modified ligand binding molecule is a phosphate binding protein (PBP). In some embodiments, the modified ligand binding molecules are labeled to be capable of RET, e.g., comprising a donor and acceptor moiety. In some embodiments of the invention, there is a detectable change in RET (e.g., FRET) when the modified ligand binding molecule binds and/or releases the ligand (e.g., phosphate). The invention also provides related methods, reactions and assays.
US08409811B2 Lectin-based glycan assay
The invention relates to the use of deglycosylated detectors, especially secondary antibodies, for the determination of sugar structures of proteins, especially recombinant proteins. It further relates to the use of deglycosylated enzymes in the determination of sugar structures with the aid of an enzyme-substrate reaction; the invention further relates to a method of determining the sugar structures of proteins, a sugar determination kit and the use of said kit for the determination of sugar structures, especially of recombinant therapeutic proteins, preferably immunoglobulins.
US08409807B2 NMR systems and methods for the rapid detection of analytes
This invention features systems and methods for the detection of analytes, and their use in the treatment and diagnosis of disease.
US08409806B2 Allelic ladder loci
Disclosed are rare short tandem repeat (STR) alleles within the D10S1248 and D12S391 loci in humans. Provided are representative allelic ladders for each locus, methods and assays using these alleles and kits containing allelic ladders comprising these alleles for accurate genotyping and identification of a wide range of individuals.
US08409804B2 Isolation of CpG islands by thermal segregation and enzymatic selection-amplification method
The present invention concerns isolation, library preparation and selective amplification from a compositionally heterogeneous pool of DNA fragments of a fraction of molecules, such as those originating from promoter CpG islands and characterized by a high GC content. In particular, the process utilizes a heat-induced segregation of DNA molecules into GC-poor, single-stranded molecule fractions and GC-rich, double-stranded molecule fractions, with subsequent enzymatic conversion of the GC-rich, double-stranded DNA molecules into a library, and, optionally, amplification. In specific embodiments, the isolation process is used to generate promoter-enriched genomic and methylome libraries for research and diagnostic applications, for example.
US08409799B2 Diagnostic test for cardiomyopathy
Methods and compositions relating to diagnosing and treating cardiomyopathy and particularly relating to methods and compositions for diagnosing and treating arrhythmogenic right ventricular dysplasia/cardiomyopathy (ARVD/C) are described. Provided are methods for screening for, diagnosing or detecting a risk of developing arrhythmogenic right ventricular dysplasia/cardiomyopathy (ARVD/C) comprising detecting the presence of a transmembrane protein 43 (TMEM43) disease associated variant in a sample of a subject, wherein the presence of a TMEM43 disease variant is indicative that the subject has ARVD/C or an increased risk of developing ARVD/C compared to an individual having wild type TMEM43.
US08409797B2 Optical sensors based on hybrid aptamer/conjugated polymer complexes
An optical sensor for detecting a target comprising a singlestranded aptamer complementary to said target, and a water-soluble cationic polythiophene derivative of the following formula: wherein “n” is an integer ranging from 6 to 100, is disclosed. The optical sensor allows for the detection of targets selected from the group consisting of potassium ions, small organic molecules, amino acids, proteins, whole cells and nucleotides. The detection is based on the formation of hybrid anionic aptamer/cationic poly-thiophene complexes.
US08409796B2 Method of regulating gene expression
The present invention relates, in general, to gene expression and, in particular, to a method of inhibiting the expression of a target gene and to constructs suitable for use in such a method.
US08409793B2 Method for preparing a sample
A method for preparing a sample consisting of biological tissue in a solid matrix includes steps of: contacting the sample with a first compressed fluid stream wherein the matrix is soluble so as to extract the solid matrix, contacting the sample with a second compressed fluid, adapted to impregnate the tissue with an aqueous or water-soluble substance, evacuating the second compressed fluid gradually and in controlled manner, recovering the sample.
US08409787B2 Method of forming a pattern in a semiconductor device and method of forming a gate using the same
A method of forming a pattern in a semiconductor device is described. A substrate divided into cell and peripheral regions is provided, and an object layer is formed on a substrate. A buffer pattern is formed on the object layer in the cell region along a first direction. A spacer is formed along a sidewall of the buffer pattern in the cell region, and a hard mask layer remains on the object layer in the peripheral region. The buffer layer is removed, and the spacer is separated along a second direction different from the first direction, thereby forming a cell hard mask pattern. A peripheral hard mask pattern is formed in the peripheral region. A minute pattern is formed using the cell and peripheral hard mask patterns in the substrate. Therefore, a line width variation or an edge line roughness due to the photolithography process is minimized.
US08409786B2 Pattern forming method and method for manufacturing semiconductor device
Double exposure is performed by using a pair of photomasks, an attenuated phase shift mask or the like which is not an alternating phase shift mask, and a pattern is transferred onto a photoresist. Here, on the occasion of performing exposure with the photomask for forming a finer pattern, double pole illumination is used as an illumination system.
US08409778B2 Resin coated carrier, two-component developer, developing device and image forming apparatus
A resin coated carrier is provided that can stably charge a toner having added thereto an external additive having a large particle size over a long period of time and can prevent blocking of a developer. The resin coated carrier satisfies the following formula (1): log(Mb/Ma)>2  (1) in which Ma is a weight average molecular weight of a silicone resin having the minimum weight average molecular weight, contained in a resin coating layer, and Mb is a weight average molecular weight of a silicone resin having the maximum weight average molecular weight, and the following formula (2) is satisfied: 0.5≦−log(A/B)≦2.5  (2) in which A is a volume resistance (Ω/cm) under electric field of 1,000 V/cm obtained by conducting a stirring test, and B is a volume resistance (Ω/cm) under electric field of 1,000 V/cm before the stirring test.
US08409776B2 Toner for developing electrostatic image, method for preparing toner for developing electrostatic image, developer for electrostatic image, toner cartridge, process cartridge, image forming method, and image forming apparatus
A toner for developing an electrostatic image, contains a binder resin having an acid value of from approximately 10 mgKOH/g to approximately 20 mgKOH/g and carbon black having a surface carboxyl group density of from approximately 2×10−6 mol/m to approximately 8×10−6 mol/m2, and is prepared in an aqueous medium.
US08409775B2 Crosslinked resin particle dispersion liquid
The present invention relates to a toner for electrophotography which has a small particle size and is excellent in all of low-temperature fusing ability, anti-hot offset property and image characteristics and a process for producing the toner, as well as to a dispersion of crosslinked resin particles which is used for production of the toner for electrophotography and a process for producing the dispersion of crosslinked resin particles. The dispersion of crosslinked resin particles having a volume median particle size (D50) of from 0.05 to 0.7 μm according to the present invention is produced by a process including the steps of (A) neutralizing a resin containing an acid group-containing polyester in an aqueous medium to obtain a dispersion of resin particles; and (B) mixing the dispersion of resin particles obtained in the step (A) with an oxazoline group-containing polymer at a temperature of from 60 to 100° C.
US08409774B2 Toner for developing electrostatic latent image
A toner for developing an electrostatic latent image, the toner comprising: a releasing agent; and a binder resin, wherein: the releasing agent includes at least a first releasing agent material and a second releasing agent material, the first releasing agent material having a different melting point compared to the second releasing agent material; and a differential scanning calorimetric curve, obtained by measuring the toner for developing the electrostatic latent image by means of a differential scanning calorimeter, exhibits a shoulder at a temperature in a range of 50° C. to 53° C. corresponding to a glass transition temperature of the toner for developing the electrostatic latent image, and also exhibits a local maximum point at a temperature in a range of 90° C. to 95° C.
US08409771B2 Laser pattern mask and method for fabricating the same
The present invention relates to a laser pattern mask, and a method for fabricating the same, which can prevent a laser pattern mask from being damaged by coating a protective film on a surface of a laser pattern mask for patterning an entire layer on a mother substrate at a time by laser ablation. The laser pattern mask includes a base substrate, a laser shielding pattern formed of a non-transparent metal on the base substrate to define laser pass through regions, and a protective film formed on an entire surface of the base substrate including the laser shielding pattern.
US08409768B2 Tuning of Fe catalysts for growth of spin-capable carbon nanotubes
Growing spin-capable multi-walled carbon nanotube (MWCNT) forests in a repeatable fashion will become possible through understanding the critical factors affecting the forest growth. Here we show that the spinning capability depends on the alignment of adjacent MWCNTs in the forest which in turn results from the synergistic combination of a high areal density of MWCNTs and short distance between the MWCNTs. This can be realized by starting with both the proper Fe nanoparticle size and density which strongly depend on the sheet resistance of the catalyst film. Simple measurement of the sheet resistance can allow one to reliably predict the growth of spin-capable forests. The properties of pulled MWCNTs sheets reflect that there is a relationship between their electrical resistance and optical transmittance. Overlaying either 3, 5, or 10 sheets pulled out from a single forest produces much more repeatable characteristics.
US08409767B2 Fuel cell
A fuel cell includes a membrane electrode assembly and separators which are stacked. A fuel gas channel allows a fuel gas to flow along a surface of one of a pair of electrodes. An oxidant gas channel allows an oxidant gas to flow along a surface of another of a pair of electrodes. A channel width of the oxidant gas channel in a central portion of the oxidant gas channel in a channel width direction is larger than a channel width of the oxidant gas channel in both end portions of the oxidant gas channel in the channel width direction. A channel width of the fuel gas channel in a central portion of the fuel gas channel in a channel width direction is smaller than a channel width of the fuel gas channel in both end portions of the fuel gas channel in the channel width direction.
US08409765B2 Co(II)tetramethoxyphenylporphyrin additive to PFSA PEMS for improved fuel cell durability
An ion conducting membrane for fuel cell applications includes an ion conducting polymer and a porphyrin-containing compound at least partially dispersed within the ion conducting polymer. The ion conducting membranes exhibit improved performance over membranes not incorporating such porphyrin-containing compounds.
US08409762B2 Adaptive method to control fuel delivery injector with modeling uncertainties in a fuel cell system
A method for adaptively controlling a fuel delivery injector in a fuel cell system, including determining a feed-forward bias for the fuel delivery injector, determining an injector flow set-point for the fuel delivery injector, monitoring stack current, determining a transient pressure correction for the stack and correcting the injector flow set-point.
US08409759B2 Seal for a fuel cell support
A unit for use in a fuel cell stack, the unit comprising a porous metal support with a seal made by local fusion and—having a seal depth that extends from the upper surface of the porous metal support to at least the bottom surface of the porous metal support, and wherein the seal is positioned along the periphery of the porous metal support, the seal being impermeable to gas transported in the plane of the porous metal support.
US08409758B2 Fuel cell system with partial external reforming and direct internal reforming
A fuel cell system includes a plurality of solid oxide fuel cells arranged in a fuel cell stack, an integrated heat exchanger/reformer operable to partially reform an anode feed prior to entry into the fuel cell stack, an anode tailgas oxidizer, and an offgas flow path extending away from an anode side of the fuel cell stack and having a first branch to selectively combine offgas from the anode side of the fuel cell stack with fuel from a fuel source to comprise the anode feed to the fuel cell stack and a second branch to supply offgas from the anode side of the fuel cell stack to the anode tailgas oxidizer. The integrated heat exchanger/reformer transfers heat from the oxidized offgas from the anode tailgas oxidizer to the anode feed before the anode feed enters the anode side of the fuel cell stack. The offgas from the anode tailgas oxidizer provides the sole heat source for the anode feed traveling through the integrated heat exchanger/reformer.
US08409745B2 Terminal pole head for a battery pack
A terminal pole head for a battery pack comprises a base element, an isolating element and the top element that assembled one upon another, so that the assembly is easy, and the appearance is smooth after assembly. Further, the base element and the top element are isolated more safely. The isolating element covers the main body of the base element with the first and the second connecting portions exposed only, so that it can avoid the occurrence of short circuit of the base element and the top element caused by mistake touch of metal object. In addition, the base element and the top element are formed with the first connecting portions, the second connecting portions, and the connecting plates, so that connecting points are scattered, which is quite important for the big power battery pack, solving the problem of temperature rise due to excessively high single point resistance.
US08409737B2 Sealed battery cell and method of manufacturing the same
An upper base portion of a top portion of a battery cell cap functions as a positive terminal, and paths for flow of electrical current are defined between the top portion and portions for welding. The portions for welding are positioned to face a side wall region between a pair of apertures adjacently provided in the top portion, and the current flowing regions are defined between the portions for welding and the side wall regions of the top portion facing to the portions for welding, each forming a symmetrical current flowing region.
US08409735B2 Microbial power generation method and microbial power generation device
Power generation efficiency of a microbial power generation device is improved by a simple and inexpensive means. Two plate-shaped cation-exchange membranes 31 are disposed parallel to each other in a tank body 30, whereby a negative electrode chamber 32 is formed between the cation-exchange membranes 31. Two positive electrode chambers 33 are each formed so as to be separated from the negative electrode chamber 32 by the corresponding cation-exchange membrane 31. An oxygen-containing gas is passed through the positive electrode chamber 33, a negative electrode solution L is supplied to the negative electrode chamber, and preferably the negative electrode solution is circulated. An acid gas (carbon dioxide gas) is introduced into the oxygen-containing gas to be supplied to the positive electrode chamber 33. Movement of Na+ and K+ ions is promoted by the pH neutralization effect produced by the acid gas, and thereby power generation efficiency can be improved.
US08409733B2 Coated cutting tool
The invention relates to a method of producing a cutting tool at least partly coated with an inner CVD coating and an outer PVD coating comprising the manufacturing steps of depositing the CVD coating, subjecting the CVD coating at least partly to an intensive wet-blasting operation, followed by depositing the PVD coating.The invention also relates to a coated cutting tool comprising a cemented carbide substrate of 5-14 wt-% Co, 0-8 wt-% cubic carbides of Ti, Ta or Nb or a combination thereof, and balance WC, said substrate being at least partly coated with a 4-14 μm thick coating comprising an inner CVD coating and an outer PVD coating wherein the CVD coating has compressive stresses.
US08409731B2 Oxide coated cutting insert
A cutting tool insert includes a body of a hard alloy of cemented carbide, cermet, ceramics, cubic boron nitride based material or high speed steel. A hard and wear resistant coating, having at least one layer, to which an (Al,Cr)2O3 layer is applied. This insert is particularly useful for machining of steel and stainless steel. The coating with a total thickness of 2-20 μm has one or several layers, at least one of which is an (Al,Cr)2O3 layer with a thickness of 1-5 μm having a corundum phase crystalline structure and a composition (Al1-yCry)2O3 with 0.4≦y≦0.6. The (Al,Cr)2O3 layer has a fiber texture with rotational symmetry in the direction of the coated surface normal to an inclination angle, φ, of the basal planes relative to the coated surface normal or the inclination angle, φ, for the highest peak in the pole plot with 70° <φ<90° .
US08409728B2 Organic electroluminescence device
An organic electroluminescence device includes an organic layer disposed between at least one pair of electrodes, wherein the organic layer includes at least one fluorescent compound selected from compounds represented by the following general formulae (1) and (2): wherein X1 to X16 each independently represents a hydrogen atom, a linear, branched or cyclic alkyl group having 1 to 20 carbon atoms, a linear, branched or cyclic alkoxy group having 1 to 20 carbon atoms, a substituted or unsubstituted aryl group having 6 to 30 carbon atoms, a substituted or unsubstituted aryloxy group having 6 to 30 carbon groups, a substituted or unsubstituted arylamino group having 6 to 30 carbon atoms, a substituted or unsubstituted alkylamino group having 1 to 30 carbon atoms, a substituted or unsubstituted arylalkylamino group having 7 to 30 carbon atoms or a substituted or unsubstituted alkenyl group having 8 to 30 carbon atoms; a pair of adjacent groups represented by X1 to X2 and a pair of adjacent substituents to groups represented by X1 to X2 may form a cyclic structure in combination; a pair of adjacent groups represented by X3 to X16 and a pair of adjacent substituents to groups represented by X3 to X16 may form a cyclic structure in combination; when the pair of adjacent substituents are aryl groups, the pair of substituents may be a single group; and in the formulae at least one of the substituents of X3 to X14 or X16 includes amino group.
US08409720B2 Optical body having polyacrylate skin layer
A multilayer optical body is disclosed. The optical body includes an optical film including polyester, a first skin layer is disposed on at least one side of the polyester optical film, and a strippable skin layer is disposed on the first skin layer. The first skin layer includes a mixture of a polyacrylate and a second polymer. Methods of making such optical bodies are also disclosed.
US08409718B2 Threaded joint for steel pipes
A threaded joint for steel pipes for use in an oil well which has galling resistance and which is protected from rusting comprises a pin and a box each having a contact surface including a threaded portion and an unthreaded metal contact portion. The contact surface of at least one of the pin and the box has a lower layer of a viscous liquid or semisolid lubricating coating comprising at least wax and a fatty acid alkaline earth metal salt and not containing a harmful heavy metal such as lead and an upper layer of a dry solid coating formed from an aqueous resin coating composition, an organic solvent type coating composition, or an ultraviolet curing coating composition.
US08409714B2 Primer composition for optical articles and optical articles
A primer coating composition is provided for an optical article capable of forming a coating layer having excellent impact resistance, abrasion resistance, and adhesion to various kinds of plastic materials without occurring of appearance faulty for an optical base material, for example, a plastic lens for an eyeglass. A primer composition for an optical article comprises; (A) aqueous dispersion of urethane resin having a polycarbonate-derived skeleton and the elongation of 200˜1000%; (B) an organic solvent having 3˜9 carbon atoms and having an ether bond or carbonyl bond and one hydroxyl group in a molecule; and (C) lower alcohol having 1˜4 carbon atoms, wherein the weight ratio of said organic solvent to said lower alcohol is from 0.01 to less than 2.00.
US08409713B2 Crosslinkable polymer host containing a nonlinear optical chromophore guest
Crosslinked films having electro-optic activity, methods for making the films, and devices that include the films. The films include a crosslinked polymer host and guest polarizable chromophore compounds.
US08409708B2 Bright pigment
A bright pigment 100 includes: a flaky substrate 10; a first layer 20 that is formed on the flaky substrate 10 and that contains one selected from the group consisting of titanium dioxide, silver and a silver alloy as its main component; and a second layer 30 that is formed so that the first layer 20 is interposed between the flaky substrate 10 and the second layer 30 and that contains the hydroxide or hydrated oxide of neodymium.
US08409707B2 Iron-based soft magnetic powder for dust core and dust core
The invention relates to an iron-based soft magnetic powder for a dust core, wherein a film comprising Fe and Co, a phosphoric acid-based chemical conversion film and a silicone resin film are formed in this order on the surface of an iron-based soft magnetic powder, and to a dust core obtained by molding the iron-based soft magnetic powder for a dust core. The invention also relates to an iron-based soft magnetic powder for a dust core formed by coating the surface of an iron-based soft magnetic powder with an insulating film, wherein the powder has a particle diameter of from 45 μm to 180 μm, the insulating film is composed of two layers in which a lower layer composed of a phosphoric acid-based chemical conversion film and an upper layer composed of a silicone resin film, and each of the films has a thickness of from 100 nm to 280 nm, and to a dust core obtained by molding the iron-based soft magnetic powder for a dust core.
US08409705B2 Rainbow fibres
Fibers having a plurality of colored regions printed on front and rear sides of said fiber are disclosed, wherein the colors are visible only under ultra-violet light. The regions may be in the form of stripes or may be arranged in a pseudo-random pattern. The regions may be differently colored. Such fibers can be incorporated into paper products as a form of counterfeit protection.
US08409704B2 Prepreg, printed wiring board, multilayer circuit board, and process for manufacturing printed wiring board
The invention relates to a prepreg, obtained by impregnating a base material with an epoxy resin composition containing an epoxy resin (A), a curing agent (B), an accelerator (C), a phenoxy resin (D), and an inorganic filler (E) and semi-hardening the impregnated material, wherein the inorganic filler (E) has an average particle diameter of 3 μm or less. When a circuit with a narrow wire distance is formed on a surface of a insulator substrate composed of such a prepreg by using a method of forming the circuit by plating process, an amount of the plating remaining on the insulator substrate surface at the circuit contour periphery can be reduced. As a result, it leads to stabilization of inter-circuit insulation resistance and increase in a yield during production of printed wiring boards.
US08409702B2 Cubic aluminum titanium nitride coating and method of making same
Coated cutting tools are disclosed which have a hard coating that includes at least one aluminum titanium nitride layer having a single phase structure of B1 cubic phase and a composition of (AlxTi1-x)N, where x is in the range of about 0.46 to about 0.52 moles. The hard coatings also have a residual stress in the range of from about −0.4 to about −3 GPa as measured by the XRD Sin2 Ψ method, and a crystallographic orientation characterized by an x-ray diffraction (200) to (111) peak intensity ratio in the range of about 1 to about 14. Preferably the aluminum titanium nitride layer has an average crystallite size in the range of about 15 to about 50 nanometers. Methods of making such coated cutting tools are also disclosed.
US08409700B2 Condensation crosslinking silicone foams
A process for producing silicone foam, involves a reaction mixture in which hydrogen is released in a first reaction of compounds with at least one Si—H group in the presence of a basic catalyst. The reaction mixture is crosslinked in a second reaction in the presence of a metal catalyst.
US08409697B2 Multilayer, heat-shrinkable film comprising a plurality of microlayers
A multilayer, heat-shrinkable film generally includes at least one bulk layer and a microlayer section comprising at least 10 microlayers, each of which has a thickness ranging from about 0.001 to 0.015 mil. The ratio of the thickness of any of the microlayers to the thickness of the bulk layer is at least about 1:2. The film has a total free shrink (ASTM D2732-03) of at least about 10% at 200° F.
US08409696B2 Multilayered coated cutting tool
A cutting tool includes a body of a hard alloy of cemented carbide, cermet, ceramics, cubic boron nitride based material or high speed steel and on which at least one of the functioning parts of the surface thereof, a hard and wear resistant coating is applied. The coating includes a polycrystalline laminar, multilayered structure of metal nitride compounds, in a repetitive form . . . MeN/(Ti1-xAlx)N/MeN/(Ti1-xAlx)N/MeN/(Ti1-xAlx)N/MeN/(Ti1-xAlx)N . . . of cubic structured (Ti1-xAlx)N layers where 0.3
US08409694B2 Coated glass and method for making the same
A coated glass includes a substrate, a first conductive layer, a metallic layer and a second conductive layer. The first conductive layer is deposited on the substrate. The metallic layer is deposited on the first conductive layer. The second conductive layer is deposited on the metallic layer. The first conductive layer and the second conductive layer are consisted of tin oxide, antimony oxide and zinc oxide, zinc oxide has a mole percentage in a range from about 30% to about 50%, antimony oxide has a mole percentage in a range from about 1% to about 5%, and the remaining is tin oxide.
US08409685B2 Optical recording medium and method for manufacturing the same
An optical recording medium includes: a substrate having a first principal surface and a second principal surface; one or plural information signal layers formed on the first principal surface of the substrate for undergoing recording or reproduction of information signals upon irradiation with light; and a barrier layer formed on the second principal surface of the substrate for suppressing the gas release from the second principal surface of the substrate, wherein an area of a region exposing from the barrier layer of the second principal surface of the substrate is not more than 688 mm2.
US08409683B2 Pressure-sensitive adhesive tape roll
A pressure-sensitive adhesive tape roll includes a bobbin and, helically wound therearound, a double-sided pressure-sensitive adhesive tape. The tape includes a double-sided pressure-sensitive adhesive body including a pressure-sensitive adhesive layer containing bubbles and/or hollow microspheres, and arranged on both sides thereof, a release liner A wider than the adhesive body, and an olefinic release liner B. In portions occupying 70% or more of the total length of the tape, a crosswise extending-off portion of the release liner A of an (n)th-turn portion of the adhesive tape vertically overlaps the adhesive body of an adjacent (n+1)th-turn portion of the adhesive tape to form an overlapping portion; the width of the overlapping portion is one half or more of the width of the adhesive body; and the adhesive body of the (n)th-turn adhesive tape is not present below the adhesive body of the adjacent (n+1)th-turn adhesive tape.
US08409675B2 Breather
The present invention provides a breather that includes a waterproof air-permeable membrane and a mounting device, the mounting device having a rod with a hollow structure and a head at one side of the rod. The head includes a bottom wall which has a circular bore in communication with the hollow portion of the rod and around which sidewalls are formed, several through holes being formed in the sidewalls, a fastening cover cooperating with the head with a chamber formed therebetween, wherein the waterproof air-permeable membrane is mounted inside the rod, and wherein the through hoes, the chamber and the circular bore communicatively connect the inside and outside of the breather.
US08409674B2 Alignment layer with reactive mesogens for aligning liquid crystal molecules
The invention relates to an alignment layer for aligning liquid crystal molecules, with improved adhesion to liquid crystal (LC) films, to a composition containing a precursor material used for the preparation of such a layer, to a laminate comprising such a layer and at least one LC polymer film, and to the use of the alignment layer and the laminate for optical, electrooptical, decorative or security uses and devices, wherein the alignment layer and the precursor material comprise at least one reactive mesogen in monomeric, oligomeric or polymeric form.
US08409673B2 Chlorobenzene derivative, optically isotropic liquid crystal medium, and optical device
A liquid crystal compound having a large refractive index anisotropy, a large dielectric anisotropy, and a low melting point, and a liquid crystal medium having a liquid crystal phase over a wide temperature range, a large refractive index anisotropy, a large dielectric anisotropy, and having an optically isotropic liquid crystal phase, are provided. The present invention is a liquid crystal compound having a chlorobenzene ring, and a liquid crystal medium characterized by containing the liquid crystal compound and a chiral reagent, and exhibiting an optically isotropic liquid crystal phase.
US08409667B2 Method for continuously annealing and preparing strip of high-strength steel for the purpose of hot-dip galvanisating it
The present application relates to a method for continuously annealing and preparing a strip of high-strength steel for the purpose of hot-dip coating it in a bath of liquid metal, in which said steel strip is treated in at least two sections, comprising in succession, when considering the direction of advance of the strip: a section called the heating and holding section, in which the strip is heated and then held at a given annealing temperature in an oxidizing atmosphere; and a section called the cooling and transfer section, in which the annealed strip at least is cooled and undergoes complete reduction, in a reducing atmosphere, of the iron oxide present in the oxide layer formed in the previous section, in such a way that the oxidizing atmosphere is separated from the reducing atmosphere, a controlled oxygen content is maintained in the heating and holding section between 50 and 1000 ppm, and a controlled hydrogen content is maintained in the cooling and transfer section at a value of less than 4% and preferably less than 0.5%.
US08409665B2 Method for reducing contact resistance of a thermally and electrically conductive structure comprising carbon nanotube
A thermally and electrically conductive structure comprises a carbon nanotube (110) having an outer surface (111) and a carbon coating (120) covering at least a portion of the outer surface of the carbon nanotube. The carbon coating may be applied to the carbon nanotube by providing a nitrile-containing polymer, coating the carbon nanotube with the nitrile-containing polymer, and pyrolyzing the nitrile-containing polymer in order to form the carbon coating on the carbon nanotube. The carbon nanotube may further be coated with a low contact resistance layer (130) exterior to the carbon coating and a metal layer (140) exterior to the low contact resistance layer.
US08409664B2 Superabsorbent polymer particles coated with a hydrophilic elastomer and absorbent article comprising such particles
Superabsorbent polymer particles, coated with a block copolymer comprising at least four blocks being at least two hard blocks, one soft block and one hydrophilic block, wherein a the soft block is sandwiched between the hard blocks.
US08409662B2 High-intensity, persistent photoluminescent formulations and objects, and methods for creating the same
Disclosed is a method for creating a photoluminescent object that is fabricated by applying to a preformed article, at least one photoluminescent formulation to result in a photoluminescent layer. The at least one photoluminescent formulation comprises at least an effective amount of at least one phosphorescent material and another effective amount of a fluorescent material.
US08409661B2 Process for producing a repair coating on a coated metallic surface
A process for producing a repair coating on a metallic surface coated with a corrosion protecting coating A applied with a pretreatment composition, an organic composition or a silicon compound containing composition. Corrosion protecting coating A has been at least partially removed in the area Z, and a thin corrosion protecting coating B containing a silicon compound is applied with a solution or dispersion containing a silane, a silanol, a siloxane, a polysiloxane or a mixture thereof on at least a part of the area Z. A further corrosion protecting coating C which is generated with an organic composition like a primer, a wet-primer, an e-coat, a powder coat, a base-coat or a clear-coat or a composition which is the same or another siloxane composition as for the thin film B may also be applied to coating B.
US08409660B2 Systems and methods for processing a magnetic disk
A system and associated methods are described for preparing a magnetic disk for installation within a disk drive system. For example, a polyfunctional lubricant may be mixed with a chemical agent to esterify the polyfunctional lubricant and cap hydroxyl groups of the polyfunctional lubricant. The magnetic disk may then be dip coated with the polyfunctional lubricant and chemical agent mixture. A polishing system then polishes the magnetic disk via an abrasive polishing tape after dip coating the magnetic disk. A portion of the chemical agent is then removed from the magnetic disk to bond a portion of the lubricant to the magnetic disk to prevent the lubricant from interfering with a read/write head when installed within a disk drive system.
US08409659B2 Nanowire supported catalysts for fuel cell electrodes
Metal oxide nanowires and carbon-coated metal nanowires are effective as supports for particles of an expensive catalyst material, such as platinum metal group catalyst. Such supported catalysts are useful when included in an electrode on, for example, a proton exchange membrane in a hydrogen/oxygen fuel cell. For example, tin oxide nanowires are formed on carbon fibers of carbon paper and platinum nanoparticles are deposited on the tin oxide nanowires. The nanowires provide good surfaces for effective utilization of the platinum material.
US08409658B2 Conformal shielding process using flush structures
In one embodiment, a meta-module having circuitry for two or more modules is formed on a substrate, which is preferably a laminated substrate. The circuitry for the different modules is initially formed on the single meta-module. Each module will have one or more component areas in which the circuitry is formed. A metallic structure is formed on or in the substrate for each component area to be shielded. A single body, such as an overmold body, is then formed over all of the modules on the meta-module. At least a portion of the metallic structure for each component area to be shielded is then exposed through the body by a cutting, drilling, or like operation. Next, an electromagnetic shield material is applied to the exterior surface of the body of each of the component areas to be shielded and in contact with the exposed portion of the metallic structures.
US08409656B2 Method of manufacturing coated needle electrodes
A method of manufacturing a coated needle electrode comprising the steps 5 of holding an uncoated sharpened needle by the tip, dipping the uncoated sharpened needle into a bath of coating material, and withdrawing the sharpened needle from the bath of coating material. In this way, the coating can be applied after the needle has been sharpened thereby allowing more precision during the sharpening process. The invention also provides an apparatus for use with the method.
US08409655B2 Process and apparatus for producing three-dimensional shaped ceramic bodies
A process for producing three-dimensional shaped ceramic bodies by layerwise printing of a suspension comprising the constituents required for formation of the shaped ceramic bodies by means of an inkjet printer in the desired two-dimensional shape onto a support material, drying and hardening of the layer composite formed, which is characterized in that printing is effected using a suspension comprising from 50 to 80% by weight of ceramic particles in a dispersion medium comprising an aqueous boehmite sol, at least one low molecular weight alcohol, at least one drying inhibitor and at least one organic fluidizer, and also an apparatus for carrying out this process are described.
US08409654B2 Production of soluble soy protein product from soy protein micellar mass (“S300/S200”)
A soy protein product having a protein content of at least 60 wt % (N×6.25) dry weight, preferably a soy protein isolate having a protein content of at least about 90 wt % (N×6.25) d.b., is formed by a soy protein micellar mass production route. The supernatant from the coalesced protein micellar mass may be processed to recover additional quantities of soy protein product. The soy protein product may be used for a fortification of soft drinks and sports drinks.
US08409651B2 High energy liquid enteral nutritional composition
High energy and high protein liquid nutrition enteral compositions are provided that contain micellar casein and caseinate, an optionally a small amount of whey.
US08409649B2 Off-note blocking sensory organic compounds
Disclosed are compounds that block off-notes in consumables and methods of blocking off-notes in consumables including off-notes provided by artificial sweeteners including aspartame, saccharin, acesulfame K (Acesulfame potassium), sucralose and cyclamate; and including stevioside, swingle extract, glyccerhizin, perillartine, naringin dihydrochalcone, neohesperidine dihydrochalcone, mogroside V, rubusoside, rubus extract, and rebaudioside A.
US08409641B2 Engineering enzymatically susceptible phytases
The invention provides a synthetic phytase polypeptide which encodes an en/ymatically susceptible phytase. Also provided are feed or food products comprising an enzymatically susceptible phytase, and transgenic plants which express the enzymatically susceptible phytase. Further provided are methods for making and using enzymatically susceptible phytases, e.g., a method of using an enzymatically susceptible phytase in feed and food processing.
US08409636B2 Chia seed extract and related method of manufacture
Ethanolic chia (Salvia hispanica) seed extracts are provided in a system including one or more polyols and at least one hydrophobic compound that solubilize hydrophobic and slightly hydrophilic fractions of the extracts. The polyol can be pentylene glycol. The at least one hydrophobic compound can be a light oil or an ester including, but not limited to, glyceryl caprylate, glyceryl trioctanoate, isodecyl neopentanoate, isononyl isononanoate, isopropyl myristate, phenethyl benzoate, propylene glycol dicaprylate/dicaprate, propylene glycol dioctanoate and combinations thereof. The system or solution can form a cosmetic composition which is highly stable. A method for preparing the composition also is provided.
US08409633B2 Methods useful in studying or modulating skin or hair pigmentation, plant extracts for use in compositions and cosmetic care method
The invention relates to methods useful in studying or modulating skin or hair pigmentation and to the use of plant extracts in compositions as well as to methods comprising the topical use of such compositions to reduce or to enhance skin or hair pigmentation.
US08409632B2 Product containing extract from Zanthoxylum avicennae (Lam.) DC., and preparation process and use thereof
Disclosed herein are a product containing an extract from Zanthoxylum avicennae (Lam.) DC. and a process for preparing the same. Also disclosed herein are a pharmaceutical composition including the aforesaid product containing the extract from Zanthoxylum avicennae (Lam.) DC., a method of treating a cancer in a subject via the aforementioned pharmaceutical composition, and a method of inhibiting tumor/cancer cells by virtue of the aforesaid product containing the extract from Zanthoxylum avicennae (Lam.) DC.
US08409630B2 Continuous processes for preparing concentrated aqueous liquid biocidal compositions
The process involves (a) continuously forming bromine chloride from separate feed streams of bromine and chlorine by maintaining said streams under automatic feed rate control whereby the streams are continuously proportioned to come together in equimolar amounts to form bromine chloride; (b) continuously forming an aqueous product having an active bromine content of at least 100,000 ppm (wt/wt), a pH of at least 7, and an atom ratio of nitrogen to active bromine greater than 0.93:1 by continuously feeding into mixing apparatus separate feed streams of (1) bromine chloride formed in (a), and (2) an aqueous solution of alkali metal salt of sulfamic acid, under automatic feed rate control whereby the feed streams are continuously proportioned to come together in amounts that produce an aqueous product having an active bromine content of at least 100,000 ppm (wt/wt), a pH of at least 7, and an atom ratio of nitrogen to active bromine from (1) and (2) greater than 0.93:1; and, (c) withdrawing said aqueous product from said mixing apparatus at a rate sufficient to enable the continuous feeding in (a) and (b) to be maintained.
US08409629B2 Hemostatic agent composition and method of delivery
A hemostatic agent composition that includes a clay hemostatic agent which is inert and non-reactive relative to blood clotting proteins and platelets, yet is capable of accelerating the formation of a stable clot when applied to an actively bleeding wound.
US08409628B2 Methods and compositions for oxygenation of skin to treat skin disorders
Methods and compositions for treating wounds, decubitus ulcers, diaper rash, burns, abrasions, and other irritations and relevant injuries are provided. The invention contemplates in one embodiment the use of an aqueous or emollient medium having one or more pH raising ingredients in a composition specifically designed to deliver oxygen to the skin's surface.
US08409627B2 Particulate wood preservative and method for producing the same
A wood preservative includes injectable particles comprising one or more sparingly soluble copper salts. The copper-based particles are sufficiently insoluble so as to not be easily removed by leaching but are sufficiently soluble to exhibit toxicity to primary organisms primarily responsible for the decay of the wood. Exemplary particles contain for example copper hydroxide, basic copper carbonate, copper carbonate, basic copper sulfates including particularly tribasic copper sulfate, basic copper nitrates, copper oxychlorides, copper borates, basic copper borates, and mixtures thereof. The particles typically have a size distribution in which at least 50% of particles have a diameter smaller than 0.25 μm, 0.2 μm, or 0.15 μm. At least about 20% and even more than 75% of the weight of the particles may be composed of the substantially crystalline copper salt. Wood or a wood product may be impregnated with copper based particles of the invention.
US08409626B2 Placental tissue grafts
Described herein are tissue grafts derived from the placenta. The grafts are composed of at least one layer of amnion tissue where the epithelium layer has been substantially removed in order to expose the basement layer to host cells. By removing the epithelium layer, cells from the host can more readily interact with the cell-adhesion bio-active factors located onto top and within of the basement membrane. Also described herein are methods for making and using the tissue grafts. The laminin structure of amnion tissue is nearly identical to that of native human tissue such as, for example, oral mucosa tissue. This includes high level of laminin-5, a cell adhesion bio-active factor show to bind gingival epithelia-cells, found throughout upper portions of the basement membrane.
US08409623B2 Cancellous bone graft substitute and method of manufacturing the same
A cancellous bone graft substitute and a method of manufacturing the cancellous bone graft substitute are provided, and more particularly, a cancellous bone graft substitute and a method of manufacturing the cancellous bone graft substitute by which defatting, demineralizing, cleaning, and sterilizing processes are performed within a short time using a supersonic cabitation without damaging a surface and an inside of a bone tissue so as to further rapidly, effectively supply an allogeneic or xenogeneic bone graft substitute. Internal and external concentrations of Ca++ of the allogeneic or xenogeneic bone graft substitute are effectively removed so as to maintain physical properties of the allogenetic or xenogeneic bone graft substitute.
US08409622B2 Process for manufacturing biocompatible material
A process for producing a biocompatible material includes the steps of mixing an extract of a fish scale-derived hydroxyapatite (with water content of 70 to 75% by weight) and of a fish scale-derived collagen (with water content of 40 to 60% by weight) in the weight percent ratio of about 8:2, stirring the mixture and drying the mixture by a hot blast in order to obtain a composite.
US08409617B2 Vitamin powder composition and method of making
A powder composition containing at least one fat-soluble vitamin dispersed in a matrix of a natural polysaccharide gum or a mixture of gums having an emulsifying capacity and/or a protein or a mixture of proteins having an emulsifying capacity. The fat-soluble vitamin in the powder compositions is in the form of droplets having an average diameter in the range of about 70 to about 200 nm. Tablets, beverages and beverage concentrates, foods, cosmetics and pharmaceuticals containing the powder composition can be made.
US08409616B2 Extended release opioid abuse deterrent compositions and methods of making same
This invention relates to an abuse deterrent dosage form of opioid analgesics, wherein an analgesically effective amount of opioid analgesic is combined with a polymer to form a matrix.
US08409607B2 Sustained release intraocular implants containing tyrosine kinase inhibitors and related methods
Biocompatible intraocular implants include a tyrosine kinase inhibitor and a biodegradable polymer that is effective to facilitate release of the tyrosine kinase inhibitor into an eye for an extended period of time. The therapeutic agents of the implants may be associated with a biodegradable polymer matrix, such as a matrix that is substantially free of a polyvinyl alcohol. The implants may be placed in an eye to treat or reduce the occurrence of one or more ocular conditions.
US08409606B2 Drug delivery through hydrogel plugs
An embodiment is a medical prosthesis for blocking or reducing tear flow through a punctum or canaliculus of a human eye and delivering a drug to the eye that comprises a dehydrated covalently crosslinked synthetic hydrophilic polymer hydrogel with dimensions to pass through a puncta lacrimali, with the dehydrated hydrogel absorbing physiological water to swell to at least 1 mm in cross-sectional width and conformably fit a canaliculus, with the hydrogel comprising a therapeutic agent dispersed through the hydrogel for release to an eye, with the hydrogel having a water content of at least about 50% by weight or volume when allowed to fully hydrate in vitro in physiological saline.
US08409604B2 Immobilized biologically active entities having a high degree of biological activity
The present invention relates to immobilized biologically active entities having heparin cofactor II binding activity.
US08409602B2 Sealants for fetal membrane repair
The present invention provides a method for preventing or repairing damage to a fetal membrane. In one embodiment, the method comprises contacting a fetal membrane with a composition comprising a four-armed catechol-terminated polyethylene glycol (cPEG) and a biocompatible oxidant. In one embodiment, the four-armed cPEG and the biocompatible oxidant are initially contained in separate solutions, and the solutions are mixed to form the composition just prior to or at the same time that the composition contacts the fetal membrane.
US08409597B2 Spray oil and method of use thereof for controlling turfgrass pests
A paraffinic spray oil and a method of using the spray oil for controlling turfgrass pests is disclosed. The spray oil comprises paraffinic oil and a quick break emulsifier, which is formulated as an oil-in-water (O/W) emulsion for use. The paraffinic oil and emulsifier are present in a weight ratio ranging from about 95:5 to about 99.95:0.05, and preferably from about 98.5:1.5 to about 99.9:0.1. When applied to turfgrass, the O/W emulsion quickly releases the oil phase upon application to the turfgrass to contact pests thereon. When provided at sufficient paraffinic oil dosages, generally at least about 0.5 gal oil/acre and preferably in the range of about 0.5 gal/acre to about 60 gal/acre, the spray oil is effective in controlling a variety of turfgrass pests, particularly insect and fungal pests, with little or no phytotoxic effects. Further, use of the spray oil as indicated for controlling turfgrass pests also enhances the growth of turfgrass.
US08409594B2 Solid oil-in-water emulsion
The present invention aims to provide solid compositions comprising an oil-in-water emulsion that have sufficient hardness and good feel when used, and can sufficiently exhibit the physiological functions of an electrolyte. A solid composition is obtained by preparing an oil-in-water emulsion by combining a solid oil (A), a liquid oil (B), a surfactant (C), a polyhydric alcohol (D), an electrolyte (E), and water (F).
US08409592B2 Whey and thymus function
The present invention generally relates to the field of nutrition and health. In particular, the present invention provides a composition that can be used to maintain or improve thymus health. One embodiment of the present invention is the use of whey or at least one protein fraction thereof for the preparation of a composition to maintain or improve thymus function.
US08409584B2 Immunotherapy targeting of the shared abnormal conformational state of amyloidogenic peptides/proteins
The present invention is directed to pharmaceutical agents and compositions useful for the treatment and prevention of amyloid disease in a subject. The invention further relates to isolated antibodies that recognize a common conformational epitope of amyloidogenic proteins or peptides that are useful for the diagnosis, treatment, and prevention of amyloid disease.
US08409582B1 Purified linear epitopes from cashew nuts, nucleic acids encoding therefor, and associated methods
Disclosed are major allergenic proteins in cashew nut, which are legumin-like proteins and 2S albumins. Also disclosed is a polypeptide allergen in the 7S superfamily, which includes vicilin-like and sucrose binding proteins. Several linear epitopes of the cashew nut are identified and characterized. The invention further discloses the sequence of cDNA encoding the allergenic polypeptide, the allergen being designated Ana o 1, and also describes the characterization of the expressed recombinant polypeptide and associated methods employing the polypeptide.
US08409579B2 Humanized anti-FGF19 antagonists and methods using same
The present invention concerns antagonists of the FGF19/FGFR4 pathways, and the uses of same.
US08409578B2 Methods for treating bone loss with antibodies to OPGL
Antibodies that interact with osteoprotegerin ligand (OPGL) are described. Methods of treating osteopenic disorders by administering a pharmaceutically effective amount of antibodies to OPGL are described. Methods of detecting the amount of OPGL in a sample using antibodies to OPGL are described.
US08409576B2 Use of IL-1beta compounds
This invention relates to methods employing IL-1β-ligand/IL-1 receptor disrupting compounds (herein referred to as “IL-1beta Compounds”); such as small molecular compounds disrupting IL-1β ligand-IL-1 receptor interaction, IL-1β antibodies or IL-1 receptor antibodies, e.g. IL-1β binding molecules as described herein, e.g. antibodies disclosed herein, e.g. IL-1β binding compounds or IL-1 receptor binding compounds, and/or RNA compounds decreasing either IL-1β ligands or IL-1 receptor protein levels, in the treatment and/or prevention of auto-inflammatory syndromes, e.g. Juvenile rheumatoid arthritis or adult rheumatoid arthritis syndrome and to methods of treating and/or preventing auto-inflammatory syndromes, e.g. Juvenile rheumatoid arthritis or adult rheumatoid arthritis syndrome, in mammals, particularly humans.
US08409575B2 Antibodies specific for amyloid beta protofibril
The invention relates to a purified antibody or fragment thereof that specifically binds an Aβ protofibril. The invention further relates to a composition that includes such antibodies. The invention also relates to using such antibodies and compositions for treating a patient having of suspected of having Alzheimer's disease.
US08409574B2 Taxane analogs for the treatment of brain cancer
Provided herein are compounds and methods for the treatment of brain cancer in a mammal, wherein the method comprises the administration to the mammal a compound that stabilizes tubulin dimers or microtubles at G2-M interface during mitosis but is not a substrate for MDR protein. In particular, the present application relates to the use of an orally effective abeo-taxane, alone or in combination with temozolomide or bevacizumab, for the treatment of brain cancer.
US08409571B2 Methods of antagonizing signal transduction in spinal cord cells
Use of antagonists to IL-31Ra and OSMRb are used to treat inflammation and pain by inhibiting, preventing, reducing, minimizing, limiting or minimizing stimulation in neuronal tissues. Such antagonists include soluble receptors, antibodies and fragments, derivative, or variants thereof. Symptoms such as pain, tingle, sensitization, tickle associated with neuropathies are ameliorated.
US08409565B2 Therapeutic target and diagnostic marker for asthma and related conditions
CD48, a surface-marker molecule present in eosinophils, is disclosed herein as a key molecule in allergic conditions, particularly in allergic airway inflammations like asthma, allergy and nasal polyposis. CD48 is thus presented as a target molecule in the treatment of said conditions. In addition, diagnostic methods, and a kit for the diagnosis of allergic inflammatory conditions are described, based on the detection of CD48 expression.
US08409558B2 Method for treatment of onychomycosis
Onychomycosis present in a nail is treated by debridement such as grinding a portion of the nail, which includes an infected portion and thereafter applying a composition containing alkyl cyanoacrylate to the debrided surface which cures to a hard layer. The hard layer can be successively ground and coated with successive layers of alkyl cycanoacrylate.
US08409556B2 Topical formulations for the prevention of sexually transmitted disease and methods of producing the same
The present invention is directed towards various topical protective formulations which may be used as an adjunct in preventing the spread of a broad range of sexually transmitted diseases. The product is intended to be used as a topical lotion, cream, emulsion, or the like. The film forming excipients and active ingredients in the following formulations have demonstrated unique skin protective barrier properties with enhanced persistence that inhibits transmission of sexually transmitted diseases.
US08409551B2 Water-releasing cosmetic makeup material
A water-releasing cosmetic makeup material that has excellent stability, exhibits good dispersion of color pigments, and ruptures smoothly upon application to provide good spreadability and superior feeling. The water-releasing cosmetic makeup material is formed of a water-in-oil emulsion comprising (a) a partially crosslinked polyether-modified silicone, a partially crosslinked polyglycerin-modified silicone, or a combination thereof, (b) an acrylic silicone-based graft copolymer, and (c) a branched silicone surfactant in an amount of 0.05 to 0.7% by mass.
US08409550B2 Method for treating skin with retinoids and retinoid boosters
A skin care product comprising from about 0.001% to about 10% of a retinoid, in combination with 0.0001% to about 50% of at combination of retinoid boosters.
US08409549B2 Aerosolized fosfomycin/aminoglycoside combination for the treatment of bacterial respiratory infections
A fosfomycin plus tobramycin combination formulation for delivery by aerosolization is described. The concentrated fosfomycin tobramycin combination formulation containing an efficacious amount of fosfomycin plus tobramycin is able to inhibit susceptible bacteria. Fosfomycin and tobramycin are formulated separately in a dual ampoule such that when reconstituted, the pH is between 4.5 and 8.0 or as a dry powder. The method for treatment of respiratory tract infections by a formulation delivered as an aerosol having mass medium average diameter predominantly between 1 to 5 μ, produced by a jet or ultrasonic nebulizer (or equivalent) or dry powder inhaler.
US08409548B2 Administration of growth factors for the treatment of CNS disorders
A method and system that is directed to the local delivery of growth factors to the mammalian CNS to treat CNS disorders associated with neuronal death and/or dysfunction is described.
US08409547B2 Radiolabelling methods
The invention relates to radiodiagnostic and radiotherapeutic agents, including biologically active vectors labelled with radionuclides. It further relates to methods and reagents labelling a vector such as a peptide comprising reaction of a compound of formula (I) with a compound of formula (II): R*-L2-C≡N+—O−  (II) or,a compound of formula (III) with a compound of formula (IV) in the presence of a Cu (I) catalyst. The resultant labelled conjugates are useful as diagnostic agents, for example, as radiopharmaceuticals more specifically for use in Positron Emission Tomography (PET) or Single Photon Emission Computed Tomography (SPECT) or for radiotherapy.
US08409546B2 Process for the preparation of zeolites having B-CHA structure
The present invention relates to a process for the preparation of zeolites having B-CHA framework structure and a composition comprising the molar ratio (n SiO2):B2O3, wherein n is at least 10, the process comprising (i) preparation of an aqueous solution containing at least one source for B2O3, at least one source for SiO2, at least one source of seeding crystals of chabazite structure, at least one organic structure directing agent (SDA) other than Tetramethylammonium hydroxide (TMAOH), acting as a template for the B-CHA structure, and Tetramethylammonium hydroxide (TMAOH), wherein the SDA or mixtures thereof are employed in such amounts that the aqueous solution in (i) exhibits a molar ratio of SDA:TMAOH of 0.01 to 5; (ii) hydrothermal crystallization of the aqueous solution according to (i); wherein B-CHA is essentially free of alkali metal and/or alkaline earth metal and the ratio of the [molar ratio (SiO2:B2O3)] of the gel composition:[molar ratio (SiO2:B2O3)] of the crystalline product having the chabazite structure is greater than 0.5.
US08409544B2 Preparation method of ferroferric oxide magnetic nanospheres
Disclosed is a process of preparing magnetite nanoparticles, comprising the following steps: 1) preparing a ferric salt mixed system, wherein a soluble ferric salt is dissolved in glycol at ambient temperature, and then urea and polyethylene glycol are added and mixed homogeneously to obtain the trivalent iron salt mixed system, the mass ratio of glycol to the trivalent iron salt being 15:1 to 60:1, glycol to urea being 20:1 to 100:1, and glycol to polyethylene glycol being 20:1 to 100:1; 2) reacting, wherein the trivalent iron salt mixed system is transferred into a reaction autoclave, sealed and placed into a heating device to react at a temperature of 200 to 300° C. for 8 to 72 hours; and 3) washing, wherein after the reaction system is naturally cooled down to ambient temperature, the product is taken out, and washed with anhydrous ethanol and water in turn to obtain the magnetite nanoparticles. The soluble iron salt includes ferric chloride, ferric sulfate, ferric acetate and ferric nitrate. The obtained nanospheres exhibit a uniform distribution of the particle diameter with a good dispersity in water. The nanospheres have superparamagnetism, and their particle diameter can be controlled by varying the reaction time as desired.
US08409536B2 Exhaust gas purification apparatus of an internal combustion engine
A technique that, in an exhaust gas purification apparatus of an internal combustion engine, can avoid a decrease in a NOx purification rate by adding a reducing agent as continuously as possible, while avoiding NH3 from passing through a selective reduction type NOx catalyst to a downstream side thereof. The selective reduction type NOx catalyst has an active spot which purifies NOx by the use of NH3, and an adsorption site which adsorbs NH3, wherein a vicinity site, which is located in the vicinity of the active spot, and a distant site, which is located distant from the active spot, exist in the adsorption site. The addition of the reducing agent from the reducing agent addition part is controlled based on the desorption rate of NH3 in the vicinity site so as to continue to cause the NH3 adsorbed to the vicinity site to exist.
US08409534B2 Control of emissions
Methods and apparatus utilizing chlorine dioxide and hydrogen peroxide are useful to reduce emissions of NOx, SOx, and heavy metals, e.g., mercury, emissions from combustion flue gas streams.
US08409531B2 Method and apparatus for storing and dispensing reagent beads
Embodiments of the invention provide an efficient and effective technique for storing and dispensing reagent beads. In some embodiments, an apparatus is provided for dispensing reagent beads contained in a bead storage device which includes a bead carrier having a plurality of wells; a plurality of reagent beads disposed in the wells; and a cover tape releasably attached to the bead carrier to cover the wells and retain the reagent beads in the wells. The apparatus comprises a channel in which to place the bead storage device with the bead carrier facing a support wall of the channel and the cover tape facing a stripping wall of the channel. The stripping wall includes a stripping gap disposed between a stripping edge and an opposite edge, and a dispense opening provided adjacent the opposite edge on a side of the stripping wall opposite from the stripping edge. The cover tape is insertable through the stripping gap to be pulled against the stripping edge to peel the cover tape from the bead carrier to move the wells of the bead carrier inside the channel toward the dispense opening and expose the wells individually to dispense the reagent beads.
US08409529B2 Histology slide and paraffin block protector and transport sleeve
A protective sheath for prolonged storage of pathology paraffin blocks. The sheath protects the paraffin block against gouging, scratching, denting, rodents, and insects. A pathology slide slides into slots in the protective sheath fixing the slide into position in protective sheath. Fixation points are built on the side of the slide to allow a user or automated system to place and retrieve protective sheath.
US08409527B2 Fluidic connectors and microfluidic systems
Fluidic connectors, methods, and devices for performing analysis (e.g., immunoassays) in microfluidic systems are provided. In some embodiments, a fluidic connector having a fluid path is used to connect two independent channels formed in a substrate so as to allow fluid communication between the two independent channels. One or both of the independent channels may be pre-filled with reagents (e.g., antibody solutions, washing buffers and amplification reagents), which can be used to perform the analysis. These reagents may be stored in the channels of the substrate for long periods amounts of time (e.g., 1 year) prior to use.
US08409522B2 Analyzing instrument, temperature control method for liquid in analyzing instrument, and analyzing apparatus
This invention relates to a technique for adjusting the temperature of a liquid held on an analyzing instrument (1) to a target value. The invention provides a temperature control method wherein thermal energy is supplied to liquid (10) by passing a magnetic flux across an analyzing instrument (1) for raising the temperature of the liquid. The invention also provides an analyzing instrument (1) and analyzing apparatus (X) which are suited to raising the temperature of a liquid (10) using a magnetic flux.
US08409521B2 Tubular reactor with jet impingement heat transfer
A tubular reactor for producing a product mixture in a tubular reactor where the tubular reactor comprises an internal catalytic insert with cup-shaped structures having orifices for forming fluid jets for impinging the fluid on the tube wall. Jet impingement is used to improve heat transfer between the fluid in the tube and the tube wall in a non-adiabatic reactor. The tubular reactor and method may be used for endothermic reactions such as steam methane reforming and for exothermic reactions such as methanation.
US08409518B2 Sulfur tolerant perovskite supported catalysts
A sulfur tolerant oxidation catalyst with appreciable NO and HC oxidation capabilities has been developed for use in any component of an exhaust aftertreatment system for a lean-burn engine where the oxidation of at least NO is desired. Several non-exclusive examples of such components where the oxidation catalyst may be employed include a DOC and a LNT. The oxidation catalyst may comprise perovskite oxide particles that support palladium particles. The ability of the palladium supported perovskite oxide particles to concurrently oxidize NO and HC's can significantly diminish or altogether eliminate the use of platinum in the exhaust aftertreatment system for at least NO oxidation. The oxidation catalyst, moreover, may exhibit superior thermal durability and better NO and HC oxidation activities than platinum in some instances.
US08409516B2 Monolith, catalyst convertor for purifying exhaust gas using the same and method for manufacturing the catalyst convertor
Provided is a catalyst converter for purifying exhaust gas and a method for manufacturing the catalyst converter, in which a heater is disposed between inner/outer monoliths, to thereby heighten a heat transfer efficiency and induce a uniform catalytic reaction, and to thereby enhance a processing performance, and minimize an electric power consumption and miniaturize a device. The catalyst converter includes: a heater having a winding portion which is wound so as to have a space therein and a pair of electric power terminals; inner and outer monoliths which are inserted in the inner and outer circumferential portions of the heater winding portion wherein each of the inner and outer monoliths includes a number of hollow cells on the surfaces of which catalysts have been coated and which are formed in the lengthy direction; and a housing in which a support assembly is assembled.
US08409515B2 Exhaust gas treatment system
An emission treatment system for a vehicle having an internal combustion engine is described. The emission treatment system has an HC-SCR catalyst including a non-Pt group metal dispersed in a ceramic matrix configured to receive an exhaust gas flow from an engine. The system also has an oxidation catalyst comprising a Pt group metal configured to receive the exhaust gas flow from the HC-SCR catalyst. The system also has a U-SCR catalyst and a diesel particulate filter, one of the U-SCR catalyst or the DPF configured to receive the exhaust gas flow from the oxidation catalyst and the other one of the U-SCR catalyst or the diesel particulate filter configured to receive the exhaust gas flow from the respective one.
US08409507B2 Automatic analyzer
An automatic analyzer includes a status table storing the status of each analysis module and reagent information identifying each reagent, the supply of which is exhausted, and allowing tracking of the status of each analysis module, etc. The automatic analyzer determines, based on the status table, whether and how it can continue current analysis, and stores the determination results in its instruction information table. The instruction information table stores analysis-unit or -module operating information and information to be supplied to the user or operator. The analysis-unit operating information includes instructions for the analysis modules to initiate an analysis in a normal manner, finish an analysis in a normal manner, omit a pre-analysis operation, omit a post-analysis operation, or stop sampling, etc. Further, the reagent information and the analysis module status are updated each time a reagent container is replaced by the operator.
US08409504B2 Method for supplying gas mixtures for an analyzer
The invention relates to a fluid analysis device that comprises an analyzer and a system for supplying an instrumentation gas to said analyzer, characterized in that the supply system includes at least one mixer generating said instrumentation gas, and at least one purifier located downstream from said at least one mixer and upstream from said analyzer.
US08409502B2 Methods, apparatuses, and applications for compliant membrane blood gas exchangers
A compliant blood gas exchanger is provided including a housing having a first end cap, a second end cap, and an elastomeric sidewall or sleeve extending there between forming a chamber. A hollow fiber assembly is disposed in the chamber. The hollow fiber assembly has a first mounting collar, a second mounting collar and a plurality of hollow fibers disposed there between. The first end cap is disposed in communication with the first mounting collar and the second end cap is disposed in communication with the second mounting collar. The end caps are connected to a gas inlet and a gas outlet. The chamber is in communication with a blood inlet and a blood outlet. The elastomeric sidewall is responsive to internal and external pressures affecting the chamber. The first chamber can also be placed adjacent to a second chamber and both chambers placed within a rigid outer housing. Thus, a dual-chamber pulsatile blood gas exchanger can be provided. That is, the second chamber may be in connection with a pump mechanism or vacuum mechanism such that the chamber creates a pulsatile flow within the first chamber.
US08409500B2 Bottle, system and method for sterilizing a liquid
A bottle, a system and a method sterilize a liquid. The bottle has an interior to hold the liquid and an ultraviolet light emitting lamp that extends into the interior. A cord may be attached to the bottle so that pulling the cord may power the ultraviolet light emitting lamp and/or charge a battery used to power the ultraviolet light emitting lamp. The bottle may have a status light that indicates that the ultraviolet light emitting lamp may have an amount of power equal to or greater than a threshold value, such as, for example, an amount of power necessary for the ultraviolet light emitting lamp to operate for ninety seconds. The bottle may have a removable lid located opposite to the ultraviolet light emitting lamp.
US08409497B2 Hot and cold rolling high strength L12 aluminum alloys
A method and apparatus for producing high strength aluminum alloys from a powder containing Ll2 intermetallic dispersoids. The powder is degassed, sealed under vacuum in a container, consolidated by vacuum hot pressing, extruded into a rolling preform and rolled into a usable part.
US08409496B2 Superplastic forming high strength L12 aluminum alloys
A method and apparatus produces high strength aluminum alloys from a powder containing L12 intermetallic dispersoids. The powder is degassed, sealed under vacuum in a container, consolidated by vacuum hot pressing, and superplastically formed into a usable part.
US08409495B2 Rotor with inlet perimeters
A device for use in a molten metal pump helps alleviate jams between rotating rotor blades and a stationary pump base. The device includes inlet perimeters that partially define one or more openings, and one or more rotor blades, wherein each rotor blade has a portion that directs molten metal into a pump chamber, and a portion that directs molten metal outwards. Each rotor blade may also include a recess that makes an opening larger to enable more molten metal to pass through the openings.
US08409494B2 Slag discharge door apparatus for electric furnace
A slag discharge door apparatus for an electric furnace is disclosed. The apparatus includes a door which is operated by a door operator to open or close a slag discharge outlet of the electric furnace, and a door support which supports the door in such a way that a portion of a lower end of the door overlaps with the door support, so that slag is inhibited from leaking out of the electric furnace through the slag discharge outlet.
US08409490B2 Polyester resin container and molding process thereof
The technical problem to be solved by this invention is to develop a polyester resin container that can be retort-processed at a temperature in the range of above 120° C. to about 130° C. The object of this invention is to provide a polyester resin container, which is capable of improving the productivity and quality of retort foods, and a molding process thereof. The process of this invention is a double blow molding process, which comprises a primary blow molding step in which a preform is biaxially drawn and blow molded into a primary intermediate product, a thermally shrink-molding step in which the primary intermediate product is heated and forcibly shrink-molded into a secondary intermediate product, and a secondary blow molding step for blow molding the secondary intermediate product into a container, wherein the process is characterized in that a mold temperature higher than 210° C. is used in the secondary blow molding step.
US08409489B2 Insertion plunger and method for inserting wrap-around labels and container bottom labels into an injection mold
An insertion plunger for inserting at least one wrap-around label and at least one bottom label into an injection mold for producing a plastic container has an outer plunger and an inner plunger that is movable relative to the outer plunger. In a method for insertion of a wrap-around label and a bottom label into an injection mold, the labels are inserted by an insertion plunger in that the wrap-around label and the bottom label are inserted in a single stroke performed by the insertion plunger into the injection mold.
US08409484B2 Method for producing a ceramic compact
A ceramic compact having a patterned conductor is obtained by coating the patterned conductor with a slurry and then by hardening the slurry. The slurry is prepared by mixing a thermosetting resin precursor, a ceramic powder, and a medium. In the ceramic compact, an isocyanate- or isothiocyanate-containing gelling agent and a hydroxyl-containing polymer are reacted and hardened to produce a thermosetting resin. The hydroxyl-containing polymer is preferably a butyral resin, an ethylcellulose-based resin, a polyethyleneglycol-based resin, or a polyether-based resin.
US08409483B2 Methods and apparatus for use in solid freeform fabrication
A method and apparatus are disclosed for producing a three-dimensional body consisting of individual solidified layers, whereby a coating material is disposed on one of a carrier plate and an already-solidified layer of the body in a first layer thickness by slidably withdrawing a bottom plate of a storage container filled with the coating material, thereby allowing coating material to descend from the storage container onto the carrier plate or already-solidified layer of the body. The first layer thickness of the coating material is then reduced to a lesser second layer thickness by re-inserting the bottom plate through the coating material disposed on the carrier plate or already-solidified layer. The coating material is then solidified at predetermined locations in order to generate a desired layer contour of one solidified layer of the three-dimensional body.
US08409482B2 Porous member
According to one embodiment of the present invention, there is provided a porous member formed by providing a member formed of a fluororesin containing carbon fiber and having a predetermined shape and exposing the member to an oxidizing gas to remove the carbon fiber contained in the member.
US08409478B2 Flame retardant composition
The invention relates to a flame retardant composition, particularly designed for fire fighting with aerial means. The retardant composition comprises a liquid ammonium polyphosphate of chain length with a value of n between 2 and 3, n being the number of condensation groups, and an ammonium polyphosphate in powder form in suspension, with a chain length with a value of n between 100 and 1500. In addition to the above, the flame retardant composition comprises corrosion inhibitors, in particular zinc orthophosphate dihydrate, and at least one surfactant agent as wetting agent or dispensing agent, an organic or inorganic thickening agent and at least one coloring agent.
US08409476B2 High work function transparent conductors
There is provided a transparent conductor including conductive nanoparticles and at least one of (a) a fluorinated acid polymer and (b) a semiconductive polymer doped with a fluorinated acid polymer. The nanoparticles are carbon nanoparticles, metal nanoparticles, or combinations thereof. The carbon and metal nanoparticles are selected from nanotubes, fullerenes, and nanofibers. The acid polymers are fluorinated or highly fluorinated and have acidic groups including carboxylic acid groups, sulfonic acid groups, sulfonimide groups, phosphoric acid groups, phosphonic acid groups, and combinations thereof. The semiconductive polymers comprise homopolymers and copolymers derived from monomers selected from substituted and unsubstituted thiophenes, pyrroles, anilines, and cyclic heteroaromatics, and combinations of those. The compositions may be used in organic electronic devices (OLEDs).
US08409474B2 Use of polynuclear phenolic compounds as stabilisers
The use of polycyclic phenolic compounds which have up to 20 benzene rings per molecule and are obtainable by reacting a tetrahydrobenzoxazine I where R1 is a hydrocarbyl radical and R2, R3, R4 and R5 are each independently hydrogen atoms, hydroxyl groups or hydrocarbyl radicals with one or more of the same or different phenols II where R7, R8, R9 and R10 are each independently hydrogen atoms, hydroxyl groups or hydrocarbyl radicals, and/or with one or more of the same or different tetrahydrobenzoxazines I, with the proviso that at least one of the substituents has from 13 to 3000 carbon atoms and the remaining substituents, when they are hydrocarbyl radicals, have in each case from 1 to 20 carbon atoms as stabilizers for stabilizing inanimate organic material against the action of light, oxygen and heat.
US08409473B2 Group II alloyed I-III-VI semiconductor nanocrystal compositions and methods of making same
A semiconductor nanocrystal composition that is stable and has high luminescent quantum yield. The semiconductor nanocrystal composition has a semiconductor nanocrystal core of a group II alloyed I-III-VI semiconductor nanocrystal material. A method of making a semiconductor nanocrystal composition is also provides which includes synthesizing a semiconductor nanocrystal core of a group II alloyed I-III-VI semiconductor material.
US08409471B2 Green phosphor and display device including the same
A green phosphor including a compound represented by Formula 1 (Y3-xMx) (Al5-yM′y)O12:Cez and a pigment. The green phosphor having the compound represented by Formula 1 and a pigment has a shorter decay time than conventional phosphors, and thereby confers excellent luminescence characteristics and color purity. A display panel including the green phosphor 1 is also provided herein.
US08409468B2 Liquid crystal composition, liquid crystal panel using the same, and liquid crystal shutter glasses
According to one embodiment, a liquid crystal composition includes a liquid crystal material and a polymer. The liquid crystal material exhibits a blue phase. The polymer has a first repeating unit containing a fluorine atom and an acrylic group.
US08409459B2 Hollow cathode device and method for using the device to control the uniformity of a plasma process
A chamber component configured to be coupled to a processing chamber is described. The chamber component comprises one or more adjustable gas passages through which a process gas is introduced to the process chamber. The adjustable gas passage may be configured to form a hollow cathode that creates a hollow cathode plasma in a hollow cathode region having one or more plasma surfaces in contact with the hollow cathode plasma. Therein, at least one of the one or more plasma surfaces is movable in order to vary the size of the hollow cathode region and adjust the properties of the hollow cathode plasma. Furthermore, one or more adjustable hollow cathodes may be utilized to adjust a plasma process for treating a substrate.
US08409455B1 Methods and devices for ultra smooth substrate for use in thin film solar cell manufacturing
Methods and devices for high-throughput manufacturing of a solar cell with a diode is provided.
US08409450B2 Graphene-based structure, method of suspending graphene membrane, and method of depositing material onto graphene membrane
An embodiment of a method of suspending a graphene membrane across a gap in a support structure includes attaching graphene to a substrate. A pre-fabricated support structure having the gap is attached to the graphene. The graphene and the pre-fabricated support structure are then separated from the substrate which leaves the graphene membrane suspended across the gap in the pre-fabricated support structure. An embodiment of a method of depositing material includes placing a support structure having a graphene membrane suspended across a gap under vacuum. A precursor is adsorbed to a surface of the graphene membrane. A portion of the graphene membrane is exposed to a focused electron beam which deposits a material from the precursor onto the graphene membrane. An embodiment of a graphene-based structure includes a support structure having a gap, a graphene membrane suspended across the gap, and a material deposited in a pattern on the graphene membrane.
US08409447B2 Separation chip and separation method
A separation chip for separating an insoluble component from a suspension using centrifugal force by rotation, includes a suspension holding tank, a separation liquid holding tank, and an insoluble component holding tank arranged in order from an inner circumferential side during rotation, wherein the suspension holding tank and the insoluble component holding tank are connected to each other, the insoluble component holding tank and the separation liquid holding tank are connected to each other by a narrow portion, and in the insoluble component holding tank, a connecting portion with the suspension holding tank is positioned further toward an outer circumferential side than the narrow portion.
US08409445B2 Method for removing gases from a container having a powdered concentrate for use in hemodialysis
An apparatus and a method for filling a container containing a dry powdered salt concentrate for use in dialysis with purified fluid and removing the trapped air or gases generated during the filling of the container, while maintaining the required fluid level in the container and without the need for evacuating gases from the container prior to filling.
US08409443B2 Vessel, dispensing devices, kits and methods for containing fluids
A device for limiting sample evaporation. The device has a vessel body having a body exterior surface and at least one body interior surface. The at least one body interior surface has one or more walls defining a first chamber, a second chamber and a conduit means. The first chamber has a first chamber opening for receiving at least one of the groups selected from a sample and a sample dispensing device. The first chamber opening defines the border of the body exterior surface and the body interior surface. The conduit means is in communication with the first chamber and the second chamber for receiving at least one of the group consisting of sample from said first chamber, a sample from a sample dispensing device and a sample dispensing device passing through or into the conduit means for placing the sample in the conduit means or into the second chamber. The second chamber is in communication with the conduit means for receiving and containing the sample from at least one of the group selected from the sample dispensing device and conduit means. The conduit means is arranged such that the sample in the second chamber is substantially isolated from the atmosphere to limit sample evaporation in the second chamber as the sample is contained therein.
US08409442B2 Water separation method and apparatus
A system for treating fractionated water from an oil and gas well. The system comprising a filter system, a diffusive membrane system, a plurality of membrane sensors, and at least one membrane controller. The filter system is fluidly connected to the diffusive membrane system, wherein the filter system comprises a plurality of straining filter banks. The diffusive membrane system comprises a plurality of membrane banks each having an inlet and an outlet. The plurality of membrane sensors are positioned at the outlet of each of the plurality of membrane banks, and the plurality of membrane sensors are configured to detect the total dissolved solids level at the outlet of each of the plurality of membrane banks. The at least one membrane controller is programmed to selectively disengage and isolate at least one of the plurality of membrane banks from fluid communication with the system upon detection if the total dissolved solids level at the outlet of one or more of the membrane banks is above about 20,000 ppm. A method is also provided.
US08409438B2 Apparatus and method for treating radioactive nitrate waste liquid
To provide an apparatus for treating a radioactive nitrate waste liquid that includes a denitrification tank (12A) which accommodates active sludge that adsorbs or takes in the radioactive substance in a nitrate waste liquid (11) and in which an anaerobic microorganism that reduces the nitrate to nitrogen gas grows, and a reaeration tank (14) in which a denitrification-treated liquid (24) treated in the denitrification tank (12A) is aerated and mixed with active sludge. A pH adjuster (21), a carbon source (22), and nitrogen gas are supplied to the denitrification tank (12A) so as to separate a denitrified liquid into a solid content and the denitrification-treated liquid (24) by using a first solid-liquid separating film (25), and the denitrification-treated liquid (24) treated with the active sludge in the reaeration tank (14) is reaerated and separated into a solid content and a reaeration-treated liquid (27) by using a second solid-liquid separating film (28).
US08409431B2 Charging apparatus
Intended is to reduce pressure fluctuations across a filter (14) for filtering a resist liquid. A charging apparatus is provided including a charge liquid tank (2) of resist liquid, a feed pump (10), a charge nozzle (8), a recovery passage (16), a recovery valve (20) disposed in the recovery passage (16), the filter (14), and a control device (24) for controlling the servomotors to adjust the openings of the charge valve (12) and the recovery valve (20) so that the pressures on the upstream side and the downstream side of the filter (14) may not fluctuate.
US08409429B2 Filter device and filter method
In order to provide a filter device for filtering a fluid medium containing solids, comprising a backflushing filter and a flushing line, by means of which fluid backflushed during a backflushing phase from the backflushing filter can be supplied to a further treatment mechanism, in which the discharging of dirt from the backflushing filter is simplified, it is proposed that the backflushing filter should have a coarse dirt outlet which is connected to the flushing line so that coarse dirt which has arrived through the coarse dirt outlet into the flushing line can be supplied to the further treatment mechanism together with the backflushed fluid during the backflushing phase.
US08409428B2 Catalyst additive for reduction of sulfur in catalytically cracked gasoline
The present invention concerns a novel additive composition for reducing sulfur content of a catalytically cracked gasoline fraction. This additive composition comprises a support consisting of porous clay into which a first metal from group IVB is incorporated and a second metal from group IIB is impregnated. Preferably, the first incorporated metal is zirconium and the second impregnated metal is zinc. The sulfur reduction additive is used in combination with a conventional cracking catalyst in a fluidized catalytic cracking process to convert hydrocarbon feed stocks into gasoline having comparatively lower sulfur content and other liquid products.
US08409422B2 Method and apparatus for producing hydrogen and oxygen gas
This invention relates to a process and an apparatus for generating hydrogen and oxygen gas by electrolysis of water. The process involves forming an electrolyte including alkaline ions and the water and generating plasma between electrodes immersed in the electrolyte by applying an electrical potential between the electrodes. The plasma ionizes the electrolyte, thereby generating hydrogen and oxygen gas. The process further involves controlling the process by relocating the generated plasma between two or more further electrodes.
US08409419B2 Conversion of carbon to hydrocarbons
The invention provides methods of forming lower alkyls and alcohols from carbon sources thermally and/or electrolytically.
US08409418B2 Enhanced plating chemistries and methods for preparation of group IBIIIAVIA thin film solar cell absorbers
The present invention provides a method and precursor structure to form a Group IBIIIAIVA solar cell absorber layer. The method includes forming a Group IBIIIAVIA compound layer on a base by forming a precursor layer on the base through electrodepositing three different films, and then reacting the precursor layer with selenium to form the Group IBIIIAVIA compound layer on the base. The three films, described by the precursor layer, include in one embodiment a first alloy film comprising copper, indium and gallium, a second alloy film comprising copper and selenium formed on the first alloy film; and a selenium film formed on the second alloy film.
US08409416B2 Device for removing foreign material from processing tank
An electrodeposition tank that pools and enables fluidization and agitation of an electrodeposition paint into which a work is to be immersed, the electrodeposition tank including: a grooved part having a plurality of concave and convex shapes formed along a work-conveying direction on a bottom surface of the electrodeposition tank; an electrodeposition paint supply pipe that circulates and supplies the electrodeposition paint to the electrodeposition tank; a plurality of branch pipes that are arranged on ridges of the grooved part and that branch off the electrodeposition paint supply pipe; and electrodeposition paint discharge nozzles provided oriented upstream in the work-conveying direction at a section of the branch pipes that opposes bottom parts of the grooved part.
US08409415B2 Manipulation of magnetic or magnetizable objects using magnetophoresis and dielectrophoresis
A device for manipulating magnetic or magnetizable objects in a medium is provided. The device has a surface lying in a plane and comprises a set of at least two conductors electrically isolated from each other, wherein the at least two conductors are adapted for both generating a magnetophoresis force for moving the magnetic or magnetizable objects over the surface of the device in a direction substantially parallel to the plane of the surface, and generating a dielectrophoresis force for moving the magnetic or magnetizable objects in a direction substantially perpendicular to the plane of the surface. Also provided is a method for manipulating magnetic or magnetizable objects in a medium. The method uses a combined magnetophoresis and dielectrophoresis actuation principle for controlling in-plane as well as out-of-plane movement of the magnetic or magnetizable objects.
US08409414B2 Gas sensor and nitrogen oxide sensor
A gas sensor and nitrogen oxide sensor, which, when fitted to the exhaust system of an internal combustion engine, can suppress the influence of harmful substances contained in a measurement gas and can prevent the reduction in sensitivity over time. A harmful substance-trapping layer is formed at a gas inlet for introducing a to-be-measured gas from an external space into an internal space, and in a buffering space formed between diffusion resistance portions. In a trap-formed portion of a gas passage in which the harmful substance-trapping layer is formed, the measurement gas can pass in an amount of 80% or more of when the harmful substance-trapping layer is not formed in the trap-formed portion. A diffusion resistance is attained in the diffusion resistance portions; a harmful substance is trapped in the harmful substance-trapping layer; and the measurement gas is allowed to flow into a detection electrode side.
US08409411B2 Nano-porous membrane based sensors
Sensors include nano-porous alumina membranes that are sensitized by immobilization of antibodies in the nano-pores. The nano-membranes can be sensitized to respond to a single target compound, or different portions of the nano-membrane can be differently sensitized. Capture of the target compound can be detected based on a spectral signature associated with electrical conductance in the nano-pores.
US08409410B2 Conductivity sensor device comprising diamond film with at least one nanopore or micropore
Sensor device for ion channel recordings; liquid-liquid measurements and resistive pulse particle counting comprising; at least one sensor element; the element comprising a diamond thin film substrate and a pore which is a nanopore or a micropore included in the substrate. This device may be used in analysis, for instance the device may be used for single molecule detection of an apialyte (e.g. DNA), for the analysis of interactions between a sensor element and an analyte, for the detection of pore forming entities, or for the determination of ion transfer.
US08409408B2 Apparatus for electrochemical modification of liquid streams
An apparatus for electrochemical modification of liquid streams employing an electrolytic cell having an oxidation site defined by an anode, an anode compartment comprising liquid electrolyte anolyte where oxidation is effected, a cathode compartment comprising liquid electrolyte catholyte where reduction is effected, a cathode comprising conducting cathode particulates forming a cathode particulates bed and a current feeder device in at least intermittent contact with said cathode particulates where the cathode particulates are in motion and the particulates motion is substantially independent of bulk electrolyte flow, a separator which confines the cathode particulates to the cathode compartment, constrains electrolyte flow through the cathode particulates bed and permits ionic conduction of current between the anode and cathode, a cathode particulates conveyance system arranged to manipulate cathode particulates motion including a magnetic subsystem having at least one source of magnetic field arranged to interact with cathode particulates via magnetic field interaction.
US08409407B2 Methods for high-rate sputtering of a compound semiconductor on large area substrates
Methods are generally provided for sputtering thin films on individual substrates. Individual substrates can be conveyed into a vacuum chamber to draw a sputtering pressure that is less than about 50 mTorr. Then, the individual substrates can be conveyed into a sputtering chamber and past a planar magnetron continuously sputtering a target by an ionized gas at the sputtering pressure such that a thin film is formed on a surface of the individual substrate. The target is subjected to a high frequency power having a frequency from about 400 kHz to about 4 MHz at power levels of greater than about 1 kW. In one particular embodiment, the method can be generally directed to sputtering thin films on individual substrates defining a surface having a surface area of about 1000 cm2 to about 2500 cm2.
US08409403B2 Production of amino lignin and amino lignin cellulose resins and adhesives
Flame retardant and water resistant products are produced from bio-based materials such as lignin cellulose containing materials. The lignin cellulose materials are modified by the method of delignification. The method of this invention utilizes an amino compound in an aqueous solution to react with the lignin in the lignin cellulose and the amino lignin and freed lignin becomes water soluble. The amino compound also reacts with the non-water soluble lignin still attached to the cellulose and also to the cellulose that is produced. Other products are produced in this method such as carbohydrates, hemi-cellulose, rosins, waxes, alcohols and other products. The amino lignin, lignin, amino lignin and amino cellulose is reacted with many organic and inorganic compounds such as aldehydes, polyisocyanates, epoxies, polycarboxylic acids, vegetable oils and many other compounds to produce resins and adhesives which may be used to produce products such as molded products, particleboard, plywood, ABS, etc. which are flame retardant and water resistant.
US08409392B2 Method of manufacturing ultra-thin and elastic keypad
The present invention pertains to a method of manufacturing ultra-thin and elastic keypad, especially comprising the processing of the elastic film, silicone adhesive, and plastic film. Wherein, the present method simply takes advantage of the steps of printing, oil pressing, and trimming to easily finish the keypad, which favorably avoids the complex process of spraying P+R, deviation from the forming of IMD products, and defectiveness of spraying and cutting applied on silicone products. Manifestly, the present invention simplifies the intricate processes, and only oil-pressing die and punching die are involved, namely less equipment and fewer personnel as well as places are required. Therefore, the present invention is uncomplicated and low-cost.
US08409389B2 Method and apparatus for adhesive bond curing
Portable apparatus for curing a part includes a wheeled frame having sliding part supports that move the part from a loading position to a curing position. A part clamping assembly is slidably mounted on the frame to apply clamping pressure to the part when the part is in the curing position in order to compact the part during a cure cycle. The clamping assembly includes a set of electrically heated shoes that heat the part to a cure temperature. A fan is provided to accelerate cool down the part after curing is complete. The heating and cooling operations are automatically performed by a programmed controller.
US08409388B2 Method and system for manufacturing optical display device
A system for manufacturing an optical display device includes an optical display unit feeding apparatus with a counting section counting the number of optical display units fed, an optical film feeding apparatus with a roll exchanging section exchanging a roll of a previous category for a roll of a latter category and joining the optical films on each, a bonding apparatus bonding a cut optical film onto a surface of an optical display unit, and a controller storing the number N of optical display units that are bonded correspondingly with the optical films that are present from a joining position to a bonding position of the optical film, and stops the apparatuses when the number of remaining sheets of the optical display units of the previous category prior to bonding becomes substantially equal to the number N at the time of exchanging categories based on information from the counting section.
US08409383B1 Passively damped vibration welding system and method
A vibration welding system includes a controller, welding horn, an anvil, and a passive damping mechanism (PDM). The controller generates an input signal having a calibrated frequency. The horn vibrates in a desirable first direction at the calibrated frequency in response to the input signal to form a weld in a work piece. The PDM is positioned with respect to the system, and substantially damps or attenuates vibration in an undesirable second direction. A method includes connecting the PDM having calibrated properties and a natural frequency to an anvil of an ultrasonic welding system. Then, an input signal is generated using a weld controller. The method includes vibrating a welding horn in a desirable direction in response to the input signal, and passively damping vibration in an undesirable direction using the PDM.
US08409378B2 Ignition charge
The invention relates to a lead- and barium-free ignition charge which does not contain any oxidant, and its use.
US08409376B2 Compositions and methods for surface abrasion with frozen particles
Certain embodiments disclosed herein relate to compositions, methods, devices, systems, and products regarding frozen particles. In certain embodiments, the frozen particles include materials at low temperatures. In certain embodiments, the frozen particles provide vehicles for delivery of particular agents. In certain embodiments, the frozen particles are administered to at least one biological tissue.
US08409374B2 Heat treatment of aluminium alloy high pressure die castings
A method for the heat treatment of a casting produced by high pressure die casting, that may exhibit blister forming porosity in the as-cast condition, of an age-hardenable aluminum alloy, includes solution treating the casting by heating the casting to and within a temperature range enabling solute elements to be taken into solid solution. The casting then is cooled to terminate the solution treatment by quenching the casting to a temperature below 100° C. The cooled casting is held in a temperature range enabling natural and/or artificial ageing. The solution treatment is conducted to achieve a level of solute element solution enabling age-hardening without expansion of pores in the casting causing unacceptable blistering of the casting.
US08409371B2 Method for producing soft magnetic metal powder coated with Mg-containing oxide film
A method for producing a soft magnetic metal powder coated with a Mg-containing oxide film, comprising the steps of adding and mixing a Mg powder with a soft magnetic metal powder which has been subjected to heating treatment in an oxidizing atmosphere at a temperature of 40 to 500° C. to obtain a mixed powder, and heating the mixed powder at a temperature of 150 to 1,100° C. in an inert gas or vacuum atmosphere under a pressure of 1×10−12 to 1×10−1 MPa, while optionally tumbling; and a method for producing a composite soft magnetic material from the soft magnetic metal powder coated with a Mg-containing oxide film.
US08409370B2 Treatment solution for insulation coating for grain oriented electrical steel sheet and method for producing grain oriented electrical steel sheet having insulation coating
A treatment solution for insulation coating for grain oriented electrical steel sheet includes at least one member selected from phosphates of Mg, Ca, Ba, Sr, Zn, Al, and Mn, and colloidal silica in a proportion of 0.2 to 10 mol in terms of SiO2 and a titanium chelate compound in a proportion of 0.01 to 4.0 mol in terms of Ti, relative to PO4: 1 mol in the phosphates.
US08409361B2 Controlling method of dishwasher
Dishwashers and methods of control for operation of dishwashers are disclosed. The operation of the dishwasher can include a drying cycle which uses a steam generator to supply steam to heat a washing compartment. The steam can evaporate moisture on the dishes in the washing compartment. When a condition of the dishwasher is met, such as a temperature or operation time meeting a preset value, an exhaust fan may exhaust air from inside the washing compartment. The operation of the dishwasher can improve power consumption and dry dishes more efficiently.
US08409357B2 Self-cleaning apparatus and method for thick slurry pressure control
Self-cleaning apparatus and methods are disclosed for handling viscous fluids, such as thick solid-liquid slurries of lignocellulosic biomass and its components, under high pressure, using an array of retractable valves.
US08409356B2 Method for glycosylating and separating plant fiber material
The invention relates to a method for hydrolyzing the plant fiber material to produce and separate a saccharide including glucose. The method includes a hydrolysis process of hydrolyzing cellulose contained in the plant fiber material and producing glucose in a first organic solvent having a cluster acid catalyst dissolved therein.
US08409355B2 Low profile process kit
Embodiments of process kits for substrate supports of semiconductor substrate process chambers are provided herein. In some embodiments, a process kit for a semiconductor process chamber may include an annular body being substantially horizontal and having an inner and an outer edge, and an upper and a lower surface; an inner lip disposed proximate the inner edge and extending vertically from the upper surface; and an outer lip disposed proximate the outer edge and on the lower surface, and having a shape conforming to a surface of the substrate support pedestal. In some embodiments, a process kit for a semiconductor process chamber my include an annular body having an inner and an outer edge, and having an upper and lower surface, the upper surface disposed at a downward angle of between about 5-65 degrees in an radially outward direction from the inner edge toward the outer edge.
US08409353B2 Water cooled gas injector
A method and apparatus for oxidizing materials used in semiconductor integrated circuits, for example, for oxidizing silicon to form a dielectric gate. An ozonator is capable of producing a stream of least 70% ozone. The ozone passes into an RTP chamber through a water-cooled injector projecting into the chamber. Other gases such as hydrogen to increase oxidation rate, diluent gas such as nitrogen or O2, enter the chamber through another inlet. The chamber is maintained at a low pressure below 20 Torr and the substrate is advantageously maintained at a temperature less than 800° C. Alternatively, the oxidation may be performed in an LPCVD chamber including a pedestal heater and a showerhead gas injector in opposition to the pedestal.
US08409352B2 Method of manufacturing semiconductor device, method of manufacturing substrate and substrate processing apparatus
An apparatus including a reaction chamber in which substrates are stacked; a first gas supply nozzle installed in a region in which the substrates are stacked; a second gas supply nozzle installed in a different position; a first branch nozzle installed at the first gas supply nozzle in a direction parallel to major surfaces of the substrates, a line of which is branched in a direction of the second gas supply nozzle, and including a first gas supply port; and a second branch nozzle installed at the second gas supply nozzle in the direction parallel to the major surfaces of the substrates, a line of which is branched in a direction of the first gas supply nozzle, and including a second gas supply port; wherein the first gas supply port and the second gas supply port are installed adjacent to each other in a direction that the substrates are stacked.
US08409350B2 Gallium nitride crystal growth method, gallium nitride crystal substrate, epi-wafer manufacturing method, and epi-wafer
Affords gallium nitride crystal growth methods, gallium nitride crystal substrates, epi-wafers, and methods of manufacturing the epi-wafers, that make it possible to curb cracking that occurs during thickness reduction operations on the crystal, and to grow gallium nitride crystal having considerable thickness. A gallium nitride crystal growth method in one aspect of the present invention is a method of employing a carrier gas, a gallium nitride precursor, and a gas containing silicon as a dopant, and by hydride vapor phase epitaxy (HVPE) growing gallium nitride crystal onto an undersubstrate. The gallium nitride crystal growth method is characterized in that the carrier-gas dew point during the gallium nitride crystal growth is −60° C. or less.
US08409348B2 Production method of zinc oxide single crystal
A production method of a zinc oxide single crystal, comprising depositing a crystal of zinc oxide on a seed crystal from a mixed melt of zinc oxide and a solvent capable of melting zinc oxide and having a higher average density than zinc oxide in the melt. Preferably, a zinc oxide single crystal is continuously pulled while supplying the same amount of a zinc oxide raw material as that of the pulled zinc oxide. A single crystal excellent in the crystal quality and long in the pulling direction can be continuously produced.
US08409345B1 Gaseous concrete raw mixture
A mixture for making gaseous concrete includes Portland cement, slaked lime, ash, aluminum gas forming material, dispersed reinforcing fiber, water, and as the gas forming material and the dispersed reinforcing fiber, it contains aluminated glass fiber, with the following ratio of components in mass %: Portland cement 30-34, Slaked lime 3-4, Ash 18-22, Aluminated glass fiber 1-5, water 37-42, Hemihydrate gypsum 0.4-0.5.
US08409344B2 Cement and methods of preparing cement
Cement compositions and methods for making cement compositions are provided. The cement compositions can comprise at least one oxide having a particle size of less than about 600 nm. The methods for making cement may include: providing a mixture of compounds containing the required calcium, silicon, aluminum, and iron to provide at least one of tricalcium silicate, dicalcium silicate, tricalcium aluminate, tetracalcium aluminoferrite, other calcium silicates, aluminates, ferrites, and silicates or combinations thereof; adding a fuel source and an oxidizer to the mixture of compounds; and heating the mixture of compounds, the fuel source, and the oxidizer such that the mixture of compounds, the fuel source, and the oxidizer ignite to form the at least one tricalcium silicate, dicalcium silicate, tricalcium aluminate, and tetracalcium aluminoferrite, or combinations thereof.
US08409339B2 CO2 recovery system and method
A CO2 recovery system includes an absorption tower and a regeneration tower. CO2 rich solution is produced in the absorption tower by absorbing CO2 from CO2-containing gas. The CO2 rich solution is conveyed to the regeneration tower where lean solution is produced from the rich solution by removing CO2. A regeneration heater heats lean solution that accumulates near a bottom portion of the regeneration tower with saturated steam thereby producing steam condensate from the saturated steam. A steam-condensate heat exchanger heats the rich solution conveyed from the absorption tower to the regeneration tower with the steam condensate.
US08409337B1 Air handling filtration equipment with adjustable media bed and method of use
A deep bed scrubber filter section comprises includes an unfiltered air input end, a filtered air output end, an airflow filtration path extending from the unfiltered air input end to the filtered air output end, a plurality of media beds along the airflow filtration path in series arrangement with one another, the media beds each having a media bed volume and each being defined by a plurality of sidewalls, two of the sidewalls of each of the media beds being perforated sidewalls at least partially intersecting the airflow filtration path, wherein an adjustable sidewall of at least one of the perforated sidewalls of a first media bed of the media beds is independently removable from the airflow filtration path and is independently adjustable to a plurality of positions along the airflow filtration path, wherein adjustment of the at least one adjustable sidewall of the first media bed alters the media bed volume of the first media bed.
US08409336B2 Air filter system
An air filter system (10) has a filter housing (11), an air filter media (12), and an electrical circuit (13) electrically coupled to the media. The filter media consists of a pleated air filter material (23) with front pleat apexes (25) and rear pleat apexes (26) which are coated with an electrically conductive material to form front vertical strips (27) and rear strips (28). The electrical circuit includes a positive front electrical contact (30) and a rear electrical contact (31). The front electrical contact has a rear surface (30′) in electrical contact with an elongated front electrical contact bar (33), oriented horizontally across and in electrical contact with the filter front strips of conductive ink. Similarly, the rear electrical contact has a front surface (31′) in electrical contact with an elongated rear electrical contact bar (34), oriented horizontally across and in electrical contact with the rear strips of conductive ink.
US08409330B2 Enhanced adsorbents and methods for mercury removal
A flue gas adsorbent and method for making an adsorbent for mercury capture are disclosed. The adsorbent comprises an admixture of an adsorptive material and an additive that have been physically combined thereby eliminating the need for traditional impregnation. A method for removing mercury from a flue gas stream is also disclosed.
US08409327B2 Control of grounded surface geometry in electrostatically enhanced fabric filters
An electrostatic filter assembly configured to be installed in equipment for removing particulate matter entrained within a gas stream. The filter assembly functions in the removal and collection of the particulate matter from the gas stream. The equipment for removing particulate matter includes a high voltage discharge electrode for imparting an electric charge to the particulate matter whereby an electrical field is produced at the filter assembly. The filter assembly includes a filter element and a supporting structure for the filter element. The supporting structure is configured to establish at the filter assembly, under the operating conditions of the equipment for removing particulate matter, an electrical field having an intensity that produces no more than a selected amount of degradation at the filter element during operation of the equipment for removing particulate matter. Also a method of manufacturing such an electrostatic filter assembly.
US08409325B2 Asymmetric gas separation membrane and process for gas separation
There is disclosed an asymmetric gas separation membrane exhibiting both improved gas separation performance and improved mechanical properties, which is made of a soluble aromatic polyimide comprised of a repeating unit represented by general formula (1): wherein B in general formula (1) B comprises 10 to 70 mol % of tetravalent unit B1 represented by general formula (B1) and 90 to 30 mol % of tetravalent unit B2 represented by general formula (B2), and A in general formula (1) comprises 10 to 50 mol % of bivalent unit A1 represented by general formula (A1a) or the like and 90 to 30 mol % of bivalent unit A2 represented by general formula (A2a) or the like.
US08409324B1 Sweep gas for membrane-based dehydration modules
An air dehydration membrane module is provided with a sweep gas which is taken from the waste gas of a pressure swing adsorption (PSA) unit. No additional compressor is required, other than the compressor forming part of the PSA unit. In another embodiment, the sweep gas includes the combination of dried product gas, taken from the dehydration membrane module, and a supplemental gas, which may be ambient air, or permeate gas from an air separation membrane, or waste gas from a PSA unit. An air ejector combines the streams, without the use of an additional compression step, and the combined gas is used as a sweep stream for the dehydration module. The invention also includes the method of selecting an optimum point at which the sweep gas is injected into the module.
US08409321B2 Method and apparatus for leaching metal from mining ore
Porous leach pipe and method for leaching metals from mining ores. The porous pipe may be buried beneath the surface of a pile of mined ore, providing a more even and uniform distribution of the leaching solution across the pile, increasing metal yields, reducing water consumption and eliminating pooling and ponding of the solution on the top of the piles as occurs with prior art drip line emitters.
US08409319B2 Silicon purification method
A silicon purification method includes a solidification purification step comprising: preparing the base material to be purified, loading the base material into a crucible, irradiating part of the base material, and fully melting the base material; gradually solidifying the base material by gradually weakening an electron beam so that the solidification proceeds until the solidifying portion occupies a first predetermined ratio of the base material; loading the remnant of the base material into the crucible, and fully melting the remnant of the base material by irradiating the entire area of the remnant of the base material with the electron beam; gradually solidifying the molten metal portion by gradually weakening the electron beam so that the solidification proceeds until the solidifying portion occupies a second predetermined ratio of the molten metal portion; and removing an unsolidified molten metal portion.
US08409318B2 Process and apparatus for forming wire from powder materials
A process and apparatus for forming wires, such as wires used as feedstock in welding, brazing, and coating deposition processes. The process and apparatus generally entail feeding through a passage a quantity of powder particles of a size and composition that render the particles susceptible to microwave radiation. As the particles travel through the passage, the particles within the passage are subjected to microwave radiation so that the particles couple with the microwave radiation and are sufficiently heated to melt at least a radially outermost quantity of particles within the passage. The particles are then cooled so that the radially outermost quantity of particles solidifies to yield a wire having a consolidated outermost region surrounding an interior region of the wire.
US08409317B2 Filter assembly with housing structure
A filter assembly for filtering fluids includes a housing having a base and a cover having guide structure for assembly. The guide structure may also provide gasket retention.
US08409315B2 Muffler
A muffler is provided that air or gas flows through to attenuate acoustic oscillations and reduce sound levels. An inner vortex and an outer vortex are created within the device that reduce noise within the rotating flow of gases. The gases flow in the outer vortex from an inlet in a live end of the housing toward a dead end of the housing. A projection is provided in the dead end of the housing that creates a low pressure area that causes the formation of the inner vortex flowing from the dead end toward the live end to an outlet.
US08409314B2 PSA filter
The PSA Filter is a non-electronic air filter utilized in the interior or exterior of any device which uses air movement as a means of ventilation or circulation including, but not limited to a computer, printer or any other type of electronic or non-electronic devices. This invention consists of a base substrate which is covered with a PSA (pressure sensitive adhesive); such that the PSA material applied to the substrate is the active filtering element, this PSA coated substrate is inserted into or on a device for the purpose of trapping dirt, dust, pollen, fibers, and any additional types of air borne contaminants, that may inadvertently enter from the outside environment through factory installed vents, or that may be created inside of the device from its normal operations, thus said contaminants become trapped onto the PSA filter surface through air-circulation.
US08409305B2 Pretreatment method for the synthesis of carbon nanotubes and carbon nanostructures from coal and carbon chars
Carbon nanostructures such as multiwalled carbon nanotubes are formed from electrolyzed coal char. The electrolyzed coal char is formed by forming a slurry of coal particles, metal catalyst and water and subjecting this to electrolysis, which generates carbon dioxide and hydrogen. This forms a coating on the particles which includes metal catalysts. These particles can be used as is for formation of multi-walled carbon nanotubes using a pyrolysis method or other method without the addition of any catalyst. The gelatinous coating can be separated from the char and used as a fuel or as a carbon source to form carbon nanostructures.
US08409300B2 Disperse azo dyes
Novel disperse azo dyes of formula (I), and processes for preparation thereof. These dyes possess superior washing fastness, sublimation fastness and light fastness.
US08409297B2 Robotic prosthesis alignment device and alignment surrogate device
A robotic prosthesis alignment device is disclosed that may automatically move the alignment of a prosthesis socket in relation to a prosthesis shank. The robotic prosthesis alignment device provides automatic translation in two axes. The robotic prosthesis alignment device includes angulation mechanics that automatically provide for plantarflexion, dorsiflexion, inversion, and eversion of the foot and shank with respect to the prosthesis socket. A surrogate device is also disclosed that can replicate the alignment achieved with the robotic prosthesis alignment device.
US08409295B2 Method and apparatus for replacing a femoral component of a hip joint
A prosthesis comprising an elongated stem for disposition within a cavity formed in a bone, the stem comprising a longitudinal axis and being configured for incremental controlled expansion laterally of the longitudinal axis, whereby to secure the prosthesis within the cavity by means of a press-fit with the surrounding bone.
US08409288B2 Transforaminal intersomatic cage for an intervertebral fusion graft and an instrument for implanting the cage
This present invention concerns a transforaminal intersomatic cage for an intervertebral fusion graft, and an instrument and method for implanting the cage, an embodiment of the cage having a body in the shape of a circular arc and comprising a lateral concave surface, a lateral convex surface, a straight upper surface, a straight lower surface and an end wall having at least one hole, called the end hole, designed to receive a rod of an instrument for implanting the cage between the vertebrae, wherein: the end hole has an orientation that is more or less tangential to the circular arc described by the body; the extremity opposite to the end wall of the body includes a return part extending the body toward the center of the circle on which the circular arc described by the body lies.
US08409287B2 Intervertebral prosthetic systems, devices, and associated methods
Intervertebral prosthetic systems, devices, and associated methods are provided. The present disclosure provides top and bottom endplates that engage the lateral walls of the vertebral bodies for stability and incorporate a compliant core, ball-and-socket core, fusion-cage core, or any other suitable type of motion-preserving or fusion cores. The endplate designs allow insertion through a unilateral approach yet still have engagement on both sides of the vertebral body to provide stability and reduce the risk of subsidence. In some instances, saddle style endplates are inserted and then rotated to engage the lateral walls of the vertebral bodies. In other instances, hinged style endplates are inserted in a first orientation and then at least one end portion is pivoted to a second orientation so that the endplates engage the lateral walls of the vertebral bodies.
US08409283B2 Vertebral implant end cap
An implant and method for insertion between adjacent vertebral members. The implant comprising an implant body with a base section having a plurality of base extensions, and an end cap adapted for selective axial positioning at a selected point on the base section and subsequent rotational adjustment about an implant axis. The end cap also comprising a fixed aperture and a variable aperture, both configured to receive and lockingly engage corresponding base extensions to securely maintain the end cap positioned on the base section. The fixed and variable passages are configured and located to permit rotational end cap adjustment. The implant imparts end cap height and angulation to an adjacent vertebral body at the selected or desired point when the implant is positioned and lockingly engaged in the intervertebral space.
US08409280B2 Breast prosthesis
The present invention relates to a breast prosthesis having at least one contact surface which is intended for contact on a body surface, with the contact surface having at least one means by means of which air circulation and/or an exchange of air can be achieved between the contact surface and the body surface.
US08409278B2 External lens with flexible membranes for automatic correction of the refractive errors of a person
The system is able to correct the spherical and cylindrical power as well as other aberrations of the optical pathway of both eyes of a person eliminating the need for multiple heavy glass lenses and mirrors. For correcting the refractive errors, the above described system is equipped with a diachroic mirror interposed in front of the system, to divert part of the light reflecting from the pupil to a Shack-Hartman wave front sensor.
US08409275B2 Prosthetic tissue valve
A prosthetic tissue valve for aortic, pulmonary, mitral or tricuspid valve replacement is described herein. A sewing ring for use with the prosthetic tissue valve is also described. The valve can have a circumference that is a predetermined distance larger than the circumference of an annulus in a defective valve. The valve can be substantially planar in an unstressed position before attachment at the annulus and substantially non-planar upon attachment in a biased position at the annulus. Methods are provided for placing the valve as described herein in the biased position within the annulus of the defective valve.
US08409272B2 Sustained drug-releasing stent
A stent includes a stent body of a cylindrical configuration having outer and inner surfaces, a first coated layer coating at least the outer surface, and a second coated layer coating substantially completely over the first coated layer. The first coated layer is prepared of a first composition comprising a polymer and a vascular intimal hyperplasia inhibitor (preferably argatroban) of a kind, which does not inhibit proliferation of endothelial cells, the weight compositional ratio of the polymer to the inhibitor being within the range of 8:2 to 3:7. On the other hand, the second coated layer is prepared of a polymer alone or a second composition comprising a polymer and a drug, the weight compositional ratio of the drug to 80% by weight of the polymer being less than 20% by weight.
US08409271B2 Stent having a locking part which prevents the strut from sliding out of the junction pipe
A stent has a stent main wire. The strut is disposed adjacent to the stent main wire and a junction pipe disposed around the stent main wire and strut so as to affix the stent main wire to the strut. A locking part is formed at an end of the strut to prevent the strut from sliding out of the junction pipe. The locking part comprises a folded back portion, wherein a distal most end of the folded back portion abuts with a distal most end of the junction pipe, a swelling portion, wherein a distal most end of the swelling portion is abutting a distal most end of the junction pipe, or a bent portion, wherein a distal most end of the bent portion is abutting with a distal most end of the junction pipe.
US08409270B2 Radiopaque compositions, stents and methods of preparation
The invention relates to an implantable radiopaque stent adapted to be disposed in a body lumen. In one aspect of the invention, a plurality of elongate filaments including one or more radiopaque filaments are arranged to form a hollow tubular structure having a tubular wall that defines an inner surface and an outer surface and opposing first open end and second open end. One of the open ends of the stent is formed by an intersection of adjacent filament ends. A radiopaque compound is applied to the intersection, the radiopaque compound comprising radiopaque material and polymeric material. The radiopaque compound and radiopaque filament provide improved external imaging of the tubular structure on imaging equipment.
US08409269B2 Procedures for vascular occlusion
A method of reducing blood flow within an aneurysm includes: injecting a contrast agent into a blood vessel including an aneurysm; deploying an occlusion device across the aneurysm; producing an image of the aneurysm including the contrast agent; and withdrawing the delivery device from the vessel after observing that the aneurysm has been obstructed by a desired amount. The image may be two-dimensional or three-dimensional. Observing that the aneurysm has been obstructed may include determining a degree of obstruction, for example by comparing an area or volume of the contrast agent in a first image and a second image. The desired amount may be a certain degree of obstruction, identification of a shape indicative of stasis such as a flat surface, an approximate hemisphere, a mushroom, or a crescent. If the occlusion device does not achieve the desired amount, a second occluding device may be deployed.
US08409268B2 Electrical conduction block implant device
The present invention provides an electrical block implant sized and shaped for securement at the perimeter of the pulmonary ostium of the left atrium. By utilizing various expandable ring designs and optional anchoring mechanisms, the present invention causes even, circular scarring around the perimeter of the pulmonary ostium, achieving reliable blocking of aberrant electrical signals responsible for atrial fibrillation.
US08409263B2 Methods to regulate polarization of excitable cells
Minimally invasive delivery with intercellular and/or intracellular localization of nano- and micro-particle solar cells within and among excitable biological cells to controllably regulate membrane polarization of such cells. The cells include retinal and other sensory cells, muscle cells, and nerve cells.
US08409262B2 Composition used for increasing calmodulin and method thereof
The present invention provides a composition used for increasing calmodulin and a method thereof. A far-infrared ray is released by a far-infrared releasing substance in the composition so as to induce intracellular calmodulin concentration increased in organisms. The far-infrared releasing substance consists of ceramic minerals and mainly comprises 80-99.9 wt % of oxide minerals including 60-95 wt % of the mineral alumina. The far-infrared releasing substance according to the present invention has the advantages of easy to carry and continuously working, so as to significantly improve the shortcoming of drugs with short-term acting.
US08409260B2 Bone screw
A bone screw having a screw member possessing a threaded section and a head and a receiving part at the head end for receiving a rod to be connected to the bone screw is provided. The receiving part has on open first bore and a substantially U-shaped cross-section having two free legs provided with a thread. Furthermore, the receiving part has a second bore on the end opposite to the first bore whose diameter is greater than that of the threaded section and smaller than that of the head. On the bottom of the first bore a seat for the head is provided. In order that the screw member can be pivoted to at least one side by an enlarged angle, the edge bounding the free end of the second bore viewed relative to the axis of the first bore is of asymmetric construction.
US08409257B2 Systems and methods for facet joint stabilization
In one form, a method for stabilization of a facet joint of the spinal column includes forming a cavity between adjacent bones defining the facet joint and positioning an implant in the cavity between the adjacent bones. In one aspect of this form, the method also includes positioning a bone anchor across the facet joint and engaging the bone anchor with each of the adjacent bones to force the bones toward one another and clamp the implant therebetween. In a further aspect of this form, the implant is a cancellous bone dowel and becomes fractured into a plurality of fragments upon being clamped between the adjacent bones and/or otherwise interacting with the bone anchor. In another form, systems and devices for performing percutaneous facet joint stabilization and/or fusion are provided. However, different forms and applications are also envisioned.
US08409253B2 Soft tissue repair assembly and associated method
A soft tissue repair assembly. The assembly includes a flexible member having first and second ends, and a strand passing through the flexible member. The strand has first and second strand ends extending through the flexible member, such that pulling at least one of the first and second strand ends changes the flexible member from a first shape suitable for insertion through soft tissue to a second shape suitable for securely lodging the soft tissue repair assembly relative to soft tissue.
US08409250B2 Meniscal repair system and method
A system and surgical methods for repairing tears in meniscal tissue using meniscal darts. In a preferred embodiment, the system includes a cannulated insertion sheath, a meniscal dart, and a disposable dart driver preloaded with a meniscal dart at its distal end. The insertion sheath is located near a meniscal tear, and sharp prongs on the tip of the sheath are used to secure and position the central fragment of the torn meniscus. The dart driver with a preloaded dart is advanced through the cannulation of the insertion sheath such that the preloaded meniscal dart at the distal end of the driver is inserted through the meniscal tear.
US08409246B2 Apparatus for performing an electrosurgical procedure
An endoscopic forceps is provided and includes a housing having a shaft. An end effector assembly operatively connects to a distal end of the shaft and has a pair of first and second jaw members. One of the first and second jaw members is movable relative to the other jaw member from an open position, to a clamping position. One of the first and second jaw members includes one or more cam slots defined therein and configured to receive a cam member that upon movement thereof rotates the movable jaw member from the open position to the clamping position. A resilient member is operably coupled to the jaw member that includes the one or more cam slots. The resilient member is configured to provide a camming force to the cam slot and to bias the first and second jaw members in the clamping position.
US08409244B2 Tool with end effector force limiter
The invention provides surgical or diagnostic tools and associated methods that offer user control for operating remotely within regions of the body: In some embodiments these tools include a proximally-located actuator for the operation of a distal end effector, as well as proximally-located actuators for articulational and rotational movements of the end effector. Control mechanisms and methods refine operator control of end effector actuation and of these articulational and rotational movements. A force limiter mechanism protects the end effector and manipulated objects from the harm of potentially excessive force applied by the operator. A multi-state ratchet for end effector actuation provides enablement-disablement options with tactile feedback. An articulation lock allows the fixing and releasing of both neutral and articulated configurations of the tool and of consequent placement of the end effector. A rotation lock provides for enablement and disablement of rotatability of the end effector.
US08409243B2 Endoscopic apparatus and method
The present invention is directed to a medical device, such as an endoscopic device, configured to be loaded into a channel of an endoscope prior to insertion of the endoscope into a body, and a method of performing an operative procedure with an endoscopic device. The endoscopic device comprises an elongate member for insertion into the channel of the endoscope, wherein a length of the elongate member is greater than a length of the channel of the endoscope. The endoscopic device also comprises a distal assembly connected to a distal portion of the elongate member and operable to perform an endoscopic operation, wherein the distal assembly has an open configuration and a closed configuration with a profile larger than a diameter of the channel of the endoscope, wherein the distal assembly is adapted to be exterior to the channel when the endoscope is inserted into the body.
US08409238B2 Mini cams on support loop for vessel stabilization
Embolic protection filtering devices and methods for making and using the same. An example filtering device includes a filter wire, a filter including a filter loop coupled to the filter wire, and a filter membrane coupled to the filter loop. A plurality of cam members may be coupled to the filter loop. Alternatively, the filter loop may include a plurality of strut members coupled thereto. The cam members and/or the strut members may help to stabilize the longitudinal position of the filtering device within a body lumen.
US08409235B2 Rotary cutting tool with improved cutting and reduced clogging on soft tissue and thin bone
A surgical cutting instrument including two coaxially arranged tubular members. The first tubular member has a cutting tip and is co-axially disposed within the second tubular member, which in turn has a cutting window to expose the cutting tip to tissue and bone through the cutting window. Movement of the tubular members with respect to each other debrides soft tissue and thin bone presented to the cutting window. The second (outer) tubular member has one or more features which contribute to reduced clogging of the cutting tip as a whole.
US08409234B2 Rotational apparatus system and method for a robotic instrument system
Robotic instrument systems, apparatus, and methods for controllably rotating a tool or adapter coupled to a distal portion of a medical instrument such as a catheter. An interface, which may be integral with the medical instrument or a component of a separate rotatable apparatus or adapter, is operably coupled, e.g. fixedly coupled, to the distal end of the instrument. A tool, such as a rotatable portion of a collar or tool base, or a working instrument operably coupled thereto, is rotatable relative to the interface. The interface and collar have guide channels. A control element extends through the medical instrument and respective guide channels such that the tool or collar is controllably rotatable about the instrument axis by axial movement of the control element relative to the instrument.
US08409231B2 Scalpel handle
The present invention relates to a contoured scalpel handle. The contoured shape of the handle provides for increased contact area with the user's hand using a larger diameter central portion and a smaller diameter trough. The generally circular cross-section allows rotation of the angle of the blade relative to the tissue without the need to change the grip on the handle. The contoured handle can be used as an adapter sleeve in which a scalpel handle can be inserted or can include a blade mounting element on which a blade is directly mounted.
US08409230B2 Method and apparatus for performing arthroscopic microfracture surgery
A microfracture instrument for applying microfracture therapy to a bone, the microfracture instrument comprising: an elongated shaft comprising a distal end and a proximal end; a needle comprising a body terminating in at least one sharp point, the needle being movably mounted to the distal end of the shaft for movement between an extended position for engaging the bone with the at least one sharp point of the needle and a retracted position for withdrawing the at least one sharp point of the needle from the bone; and a drive shaft movably mounted to the elongated shaft, the drive shaft being connected to the body of the needle so that movement of the drive shaft relative to the elongated shaft moves the needle between its extended position and its retracted position.
US08409224B2 Suturing graft tubes to lumen walls percutaneously
A graft tube is percutaneously placed inside the lumen of a vessel and attached to the lumen wall by loops of suture material. The plurality of short sutures are made in the shape of a loop with a sharp and a blunt end then forced into a plurality of first tunnels located in sections of circular cuffs that are attached to graft tube ends. The short sutures are pushed out the first tunnel by push rods and curve back to their original shape through the adjacent lumen wall and into a plurality of second tunnels where the short sutures are lodged.
US08409220B2 Flexible endoscopic surgical instrument for invagination and fundoplication
An endoscopic surgical instrument includes a flexible tube, a grasping and fastening end effector coupled to the distal end of the tube, and a manual actuator coupled to the proximal end of the tube. The manual actuator is coupled to the end effector by a plurality of flexible cables which extend through the tube. The tube contains a lumen for receiving a manipulable endoscope and the end effector includes a passage for the distal end of the endoscope. The end effector has a store for a plurality of male fastener parts, a store for a plurality of female fastener parts, a rotatable grasper, a rotatable fastener head for aligning a female fastener part and a male fastener part with tissues therebetween, and a firing member for pressing a male fastener part through tissues grasped by the grasper and into a female fastener part. According to a presently preferred embodiment, the overall diameters of the flexible tube and the end effector (when rotated to the open position) do not exceed approximately 20 mm so that the instrument may be delivered transorally to the fundus of the stomach. The manual actuator is provided with a lock-out feature which prevents firing male fastener parts before the fastener head is closed. The instrument is advantageously utilized in a fundoplication procedure.
US08409214B2 Portable regulated vacuum pump for medical procedures
In various embodiments of the invention, an electro-vacuum pump can be used either as a stand alone unit to create, monitor and control a vacuum or to maintain, assist or as a back up for a hand operated pump in a variety of surgical procedures. The vacuum pump is controlled by a processor and is automatically activated when the vacuum is below a pre-selected parameter or a parameter selected on the fly by the surgeon. Visual or audio feedback is used to allow the surgeon increased control of the vacuum device while carrying out the surgical procedure.
US08409209B2 Method and apparatus for performing an open wedge, high tibial osteotomy
An osteotomy implant for disposition in a wedge-shaped osteotomy opening in a bone, the implant comprising a body for disposition within the wedge-shaped osteotomy opening in the bone and supporting the bone while healing occurs; at least one key formed integral with the body for stabilizing the body relative to the adjacent bone while healing occurs; and at least one fenestration extending through the body for permitting bone growth through the implant.
US08409208B2 Device and method to access the anterior column of the spine
Methods and devices are configured to permit a surgeon to access the anterior column of the spine without significant manipulation of intervening nerve elements.
US08409205B2 Fixation device for intramedullary nail
A fixation device for an intramedullary nail for proximal femoral fractures, including a main intramedullary nail, a combined locking nail, and cortical bone screws. The main intramedullary nail has a longitudinal axis, a proximal end, and a distal end with a tip. The proximal end includes a through hole for assembling the combined locking nail. The distal end includes an oblong through hole and a circular through hole, both for receiving the cortical bone screws. The combined locking nail includes a head, a distal end of the locking nail, a sleeve, a connecting block, and a cover cap. The connecting block includes a left-handed external thread. The cover cap includes a left-handed internal thread matching with the external thread of the connecting block, a symmetrical sliding plane, and a protrusion block disposed at the end of the symmetrical sliding plane.
US08409203B2 Implantable medical implants having fasteners
A surgical fastening system for implantable devices such as injection port systems. The implantable device may contain a plurality of fasteners in pre-deployment position, may have a housing fitted over or around it which contains a plurality of fasteners in pre-deployment position, or may be a part of a two-part system into which it fits. Accordingly, the present invention also encompasses a deployment system or tool that optionally positions the implantable device, and which causes the fasteners to move into post-deployment position. The fasteners may be staples, metal loops, coils, springs or hooks formed of biocompatible materials, including shape memory alloys such as NiTi.
US08409201B2 Percutaneous patellar osteosynthesis system applicable to dislocated patella fractures
The present invention relates to a percutaneous patellar osteosynthesis system applicable to any type of fracture of the knee cap, formed by two arms that contain two multidirectional movable securing devices for fitting to any type of knee cap, in which the arms close in a parallel manner by means of a scissors closure mechanism in order to keep the fragments confined and secured by means of a “zipper” based on manual compression. The devices for securing the knee cap have antero-posterior, up/down and also lateral mobility in order to mobilize the fractured fragments and to achieve a reduction and a satisfactory knee cap joint congruence. The arms have slidable guides for placing the implant in any required direction in order to keep the fragments stable, the guides slide on the arms and the parallelism sought in this type of fixing is achieved without having to be based on manual calculation, the latter customarily being used in broad tissue dissection. The system achieves reduction and internal fixing by means of a minimally invasive technique and less tissue damage. The system also has guides for fitting cerclage wiring on an implant of any configuration, facilitating reduction and fixing of patellar fractures and the taking of X-rays with the system in place.
US08409198B2 Clamp based methods and apparatus for forming lesions in tissue and confirming whether a therapeutic lesion has been formed
Surgical systems, devices and methods including one or more tissue stimulation elements that, in some instances, may also be used for sensing purposes. Some of the surgical devices also include a tissue coagulation element.
US08409197B2 Methods of cutting tissue using a medical instrument
In an embodiment, a method for cutting tissue comprising inserting at least a portion of a medical instrument into a body; and cutting tissue of the body with first and second blades of the medical instrument, wherein the first blade includes: a first member having a shearing surface; an electrically insulative member supported by the first member; and a conductive member adjacent to the electrically insulative member and electrically insulated from the first member by the electrically insulative member.
US08409192B2 Controlling coagulum formation
Some embodiments of a medical instrument can be configured to reduce the formation of coagulum by delivering a negative charge bias to conductive surfaces that interface with blood or bodily tissue during a medical procedure. The application of the negative charge at the instrument-blood interface can reduce the fibrinogen deposition and the formation of coagulum because fibrinogen molecules in general are negatively charged at neutral pH levels. In addition, some embodiments of the instrument may be configured to irrigate the instrument-blood interface with RGD/ClfA peptides, a bicarbonate solution (or other high pH solution), or both to further repel the fibrinogen and thereby inhibit the formation of coagulum. Accordingly, some embodiments of the medical instrument can substantially reduce the risks of thromboembolism during particular medical procedures.
US08409188B2 Ablation devices with adjustable radiating section lengths, electrosurgical systems including same, and methods of adjusting ablation fields using same
An energy applicator for directing energy to tissue includes a feedline and a radiating section operably coupled to the feedline, wherein the radiating section has a length. The energy applicator also includes a length adjustment member adapted to allow for selective adjustment of the length of the radiating section.
US08409186B2 Crest factor enhancement in electrosurgical generators
The present disclosure relates to an electrosurgical generator which includes a controller configured to generate a first pulse train having at least one first control pulse and at least one first reset pulse. The controller also includes a second pulse train having at least one second control pulse and at least one second reset pulse. The first control pulse(s) and the second control pulse(s) are asynchronous and the reset pulse(s) are synchronous. The electrosurgical generator also includes an RF output stage which includes a first switching element and a second switching element. The control pulses are configured to activate the first switching element and second switching elements, respectively, in an asynchronous fashion to generate a non-continuous RF waveform.
US08409182B2 Laser-assisted thermal separation of tissue
A laser-assisted method for fully or partially separating tissue such as collagen-containing tissue is provided. In one embodiment, the method pertains to a capsolurorhexis whereby the laser-assisted method is applied to the lens capsule. A light-absorbing agent is added into or onto the tissue. A light beam with a wavelength capable of being absorbed by the light absorbing agent is then directed at the tissue to cause a thermal effect at the tissue following a predetermined closed curve with the goal to avoid irregularity or potential tears in the resulting rim of the tissue.
US08409178B2 Systems and methods for evaluating treatment tables for refractive surgery
Treatment table verification techniques involve comparing intended refraction information with expected optical refraction information, and validating or qualifying the treatment table based on such comparisons. Systems and methods for verifying treatment tables provide enhanced safety for laser vision correction treatments.
US08409176B2 Method and device for laser lithotripsy
A system/method for destruction/ablation of stones, calculi or other hard substances using laser is disclosed. Lithotripsy is particularly benefitted. The system comprises a diode laser source, one or more optical fibers and a liquid delivery system creating a liquid environment around stones (calculi). At least one emitted wavelength is highly absorbed in surrounding/covering medium, causing evaporation and cavitation effects that lead to stone/calculi destruction. Different radiation configurations may be used. in one embodiment continuous radiation is used to create sparkler-less plasma bubbles to destroy hard substances. In another embodiment high peak power pulsed radiation is used. Wavelengths of 1470 nm, 1940 nm, or 1550 nm are preferred. Additionally device/method is used with another wavelength having absorption in water e.g. 980 nm. Safer/improved methods/system provide enhanced lithotripsy treatments with shorter treatment times to destroy a wider range of stones with less tissue damage risk.
US08409173B2 Holding device for medical purposes
The invention relates to a holding device for medical purposes having a carrier arm on whose distal end at least one medical instrument can be secured and having at least one joint for positioning the carrier arm and/or the medical instrument, wherein the at least one joint can be transferred between a position that releases the joint and a position that blocks the joint and wherein the at least one joint is coupled with a touch sensor for actuating the joint. To produce a holding device for medical purposes that ensures simple construction, simple handling, and reliable positionability, it is proposed with the invention that the sensor should be coupled with the medical instrument mounted on the distal end of the carrier arm.
US08409172B2 Systems and methods for performing minimally invasive procedures
A robotic surgical system includes an instrument driver and an instrument assembly operatively coupled to the instrument driver such that mechanisms of the instrument driver operate or control movement, operation, or both, of components of the instrument assembly. The instrument assembly components include an elongate flexible guide instrument, an optical light source, a camera and a working tool, wherein the light source, camera, and working tool are carried in one or more lumens of the guide instrument. An operator control station is operatively coupled to the instrument driver via a remote communication link. The instrument assembly further includes an inflatable visualization balloon carried on a distal end portion of the guide instrument, the light source and camera having distal ends located within an interior of the balloon, the balloon comprising a lumen extending from the guide instrument to a distal facing wall of the balloon, such that the working instrument may extend from a respective lumen of the guide instrument through the balloon lumen to contact body tissue when the distal end of the guide instrument is positioned in an interior body region.
US08409167B2 Devices for delivering substances through an extra-anatomic opening created in an airway
Devices and methods for delivering substances to lung tissue through an extra-anatomic passage created in an airway.
US08409166B2 Method for pressure mediated selective delivery of therapeutic substances and cannula
Methods and devices are disclosed for selective delivery of therapeutic substances to specific histologic or microanatomic areas of organs. Introduction of the therapeutic substance into a hollow organ space (such as an hepatobiliary duct or the gallbladder lumen) at a controlled pressure, volume or rate allows the substance to reach a predetermined cellular layer (such as the ephithelium or sub-epithelial space). The volume or flow rate of the substance can be controlled so that the intralumenal pressure reaches a predetermined threshold level beyond which subsequent subepithelial delivery of the substance occurs. Alternatively, a lower pressure is selected that does not exceed the threshold level, so that delivery occurs substantially only to the epithelial layer. Such site specific delivery of therapeutic agents permits localized delivery of substances (for example to the interstitial tissue of an organ) in concentrations that may otherwise produce systemic toxicity. Occlusion of venous or lymphatic drainage from the organ can also help prevent systemic administration of therapeutic substances, and increase selective delivery to superficial epithelial cellular layers. Delivery of genetic vectors can also be better targeted to cells where gene expression is desired. The access device comprises a cannula with a wall piercing tracar within the lumen. Two axially spaced inflatable balloons engage the wall securing the cannula and sealing the puncture site. A catheter equipped with an occlusion balloon is guided through the cannula to the location where the therapeutic substance is to be delivered.
US08409162B2 Absorbent articles with refastenable side seams and intuitive disposal feature
A disposable absorbent article including a pair of first fasteners, at least a portion of each first fastener being situated inboard from each longitudinal side edge in the first waist region, each first fastener being adapted to engage at least a portion of the inner surface of the second waist region, each first fastener comprising a resilient material. The disposable absorbent article also includes a disposal fastener, at least a portion of the disposal fastener being situated inboard from the longitudinal side edge in the second waist region, the disposal fastener adapted to engage at least a portion of the outer surface, the disposal fastener comprising a resilient material.
US08409161B2 Remote sensing catheter system and methods
A remote sensing catheter system including an injection catheter and a collection catheter. In one method of use, an external sensor of the system determines the timing of operation of the collection catheter. In another method of use, a sensor determines the volume of medium in the injection.
US08409159B2 Methods and devices for applying closed incision negative pressure wound therapy
A surgical tissue therapy device includes a sealant layer and a collection chamber. The sealant layer functions so as to create a sealed enclosure, or space between it and the surface of a patient, by forming an airtight seal around a surgical area of skin trauma. The closed incision tissue therapy device also comprises a collection chamber, which may comprise an elongate tubular chamber with a plurality of longitudinally spaced openings. The collection chamber may be configured to be in fluid communication with the sealant layer and the area of skin trauma and functions as to distribute the negative pressure applied to a surgically closed area of skin trauma. Preferably, the pressure under the sealant layer is reduced by expanding the volume of the enclosure space and thereby decreasing the density of air molecules under the sealant layer. The collection material may comprise a material and/or a configuration that permits length changes based upon the length of the corresponding surgical wound or incision.
US08409157B2 Wound dressing with vacuum reservoir
A wound dressing apparatus includes a wound dressing member dimensioned for positioning relative to a wound bed. The wound dressing member including an internal vacuum reservoir and has a port in communication with the vacuum reservoir for applying subatmospheric pressure to the vacuum reservoir to facilitate removal of fluid from the wound bed. The wound dressing member includes a visual pressure indicator associated therewith for indicating a level of pressure within the vacuum reservoir. The visual pressure indicator includes color indicia having a plurality of colors corresponding to a condition of the pressure within the vacuum reservoir. The wound dressing member includes a lower absorbent member positionable adjacent the wound bed and an upper member which at least partially defines the vacuum reservoir. At least one of the top member and the lower absorbent member has the visual pressure indicator mounted thereto.
US08409151B2 Disposable infusion device filling apparatus and method
An infusion system includes a disposable wearable infusion device and a filler device. The disposable infusion device has a body arranged to be adhered to a patient's skin and a reservoir for holding a liquid medicant to be infused into the patient. The filler device is arranged to detachably receive the infusion device body and to transfer a volume of the liquid medicant to the infusion device reservoir. The filler device may be part of a service device arranged to detachably receive the infusion device and which also includes a cannula driver and a cannula for providing the infusion device with a cannula and deploying the cannula to beneath a patient's skin.
US08409143B2 Infusion pump assembly
An infusion pump assembly is disclosed. The infusion pump assembly includes a locking tab and a pump barrel inside a pump barrel housing, where the pump barrel accommodates a reservoir assembly. The reservoir assembly includes a reservoir and a plunger rod. The infusion pump assembly also includes a locking disc at a terminus of the pump barrel. The locking disc includes a clearance hole for the plunger rod. The locking disc also includes at least one locking tab notch in close proximity with the locking tab. The locking tab is in moveable engagement with the locking tab notch, and the reservoir moves the locking tab from a locked position to an unlocked position when the plunger rod is inserted through clearance hole. The locking disc rotates upon torque being applied to the reservoir assembly, the locking disc rotating from a non-loaded position to a loaded position with respect to the plunger rod and a drive screw.
US08409142B2 Operating an infusion pump system
Some embodiments of a medical infusion pump system include a pump device having a cap device that mates with a pump housing to retain a medicine cartridge therein. In addition to retaining the medicine cartridge in the pump housing, the cap device may perform a number of preparatory functions or safety functions. In addition or in the alternative, some embodiments of the pump device may include a drive system that advances a piston rod to dispense medicine to the patient in a safe and energy efficient manner.
US08409141B2 Auto injector with automatic needle retraction
The present application relates to a disposable auto injector (10) that can be safely operated for automatic injection of a dose of medication and having a housing (12) for accommodation of a syringe (18) with a needle (20), the syringe being movably positioned in the housing between a first position in which position the needle is accommodated inside the housing and a second position in which position the needle protrudes outside the housing (22), a driver configured for applying a force to the syringe thereby moving the syringe from the first position to the second position, and wherein the driver is also configured for applying a force to the syringe thereby moving the syringe from the second position to a retracted position in which position the needle is accommodated inside the housing upon user operation of a release member (42).
US08409138B2 Delay mechanism for automatic injection device
A delay mechanism for staging the operation of an automatic injection apparatus (20) to ensure medication contents are properly delivered prior to the needled syringe (32) of the apparatus being retracted. In one form, the delay mechanism includes a shuttle (50), a follower (110), a locking member, a damping compound, and a driver and a driver biasing element (44). The shuttle is for a needled syringe of the apparatus and includes a first latching element. The follower includes a second latching element and a cammable surface, which second latching element is for cooperating with the first latching element to limit motion of the shuttle relative to the follower in a second direction opposite the first direction. The locking member is movable from a locking position to a release position by engagement with the syringe plunger during an injection, the locking member, when in the locking position, preventing rotation of the follower relative to the shuttle, the locking member, when in the release position, allowing rotation of the follower relative to the shuttle. The damping compound is between the follower and a supporting surface to dampen rotation of the follower relative to the shuttle. The driver is rotatably fixed relative to the shuttle and includes a camming surface. The shuttle allowing retracting of the syringe needle into the housing of the automatic injection apparatus after injection.
US08409136B2 Robotic catheter system
A robotic catheter system includes a controller with a master input device. An instrument driver is in communication with the controller and has a guide instrument interface including a plurality of guide instrument drive elements responsive to control signals generated, at least in part, by the master input device. An elongate guide instrument has a base, distal end, and a working lumen, wherein the guide instrument base is operatively coupled to the guide instrument interface. The guide instrument includes a plurality of guide instrument control elements operatively coupled to respective guide drive elements and secured to the distal end of the guide instrument. The guide instrument control elements are axially moveable relative to the guide instrument such that movement of the guide instrument distal end may be controlled by the master input device.
US08409134B2 Power injector having calibrated pressure monitoring functionality
Control logic (110) for a power injector is disclosed, where this power injector control logic (110) includes a syringe fill protocol (114), a pressure calibration protocol (116), a pressure monitoring protocol (118), and an injection protocol (120). The power injector control logic (110) is configured to execute the pressure calibration protocol (116) on each execution of the syringe fill protocol (114). The pressure calibration protocol (116) updates the pressure monitoring protocol (118), which is executed during execution of the injection protocol (120).
US08409133B2 Drug delivery device with sensor for closed-loop operation
An apparatus and a system for controlling and/or managing administration of a drug to a body of a patient. The apparatus includes a drug infusion device configured to deliver drug at a predetermined location in the body of the patient, at least one sensor disposed in the drug infusion device and configured to measure a. corresponding property related to the patient and selected from the group consisting of physiological properties, biochemical properties, environmental properties and drug-related properties, a controller disposed in the drug infusion device and configured to receive from the at least one sensor data representative of the measured corresponding property and based on the received data, determine a drug delivery rate. The drug delivery device is configured to deliver the drug to the body of the patient based on the determined drug delivery rate.
US08409127B2 Blood processing device and method for purging a set of blood lines on a blood processing device
A method for emptying a blood tubing set of a blood treatment device that includes an extracorporeal blood circuit with a membrane filter includes supplying air or gas to the blood tubing set to displace liquid therein. The blood tubing set includes arterial and venous patient blood tubes in communication with a first chamber of the membrane filter. The device also includes a substituate line which opens into the arterial blood tube and/or into the venous blood tube, and a substituate pump. To empty the blood tubing set, the arterial blood tube and the venous blood tube are connected to one another to provide a circuit that includes the membrane filter, the arterial blood tube, and the venous blood tube. The substituate line is disconnected, and the air or gas is pumped into the blood tubing set so as to displace liquid into a second chamber of the membrane filter.
US08409126B2 Selective cytopheresis devices and related methods thereof
The present invention relates to systems and devices to treat and/or prevent inflammatory conditions within a subject and to related methods. More particularly, the invention relates to systems, devices, and related methods that sequester leukocytes and/or platelets and then inhibit their inflammatory action.
US08409125B2 Adaptable perioperative cell-salvage system and methods and disposable units for same
A blood-collection system configured to permit selection of either collection and disposal of shed blood from a patient or collection and processing of shed blood for autologous transfusion back to the patient includes an automated blood-processing machine. The system may also include a blood-collection reservoir, a separation chamber, and a fluid conduit. The blood-collection reservoir may be engageable with the blood-processing machine so that the machine can identify and report the presence of blood in the reservoir. The separation chamber may also be engageable with the blood processing machine. The fluid conduit may be configured to selectively join the reservoir to the separation chamber by a quick-connect coupling.
US08409122B2 Back orthosis and orthotic method
A lumbar orthosis that includes first and second, separate, opposing and mating front attachment panels; and a separate, laterally adjustable, rigid lumbar compression piece configured for positioning only at the rear of a wearer, wherein pulling of a cord causes the brace both circumferentially to tighten and to concentrate compression and pressure of the separate, laterally adjustable, rigid lumbar compression piece directly and especially upon a spinal region of a wearer's back with the aid of a mechanical advantage dependant upon a number of apertures through which the cord or cords pass. An orthosis and method for correcting lumbar and thoracic back pain and disorders is also disclosed.
US08409119B2 Walking assistance device
A walking assistance device including a pelvic frame (10) extending from a lower back to each lateral side of a user, and a belly belt (20) for securing the pelvic frame in position. A power generator (30) is attached to each lateral side of the pelvic frame. A power transmitting arm (40) can be attached to an output member (33) of the power generator simply by hooking an upper part of a base end (41) of the power transmitting arm onto an upper groove (38) of the output member, and pushing a latch member or a slider (46) provided in a lower part of the base end onto a lower groove (39) of the output member. The user wearing the pelvic frame (10) can easily attach the power transmitting arm (40) to the output end of the power generator (30) by easily using a single hand without requiring help.
US08409118B2 Upper arm wearable exoskeleton
An exoskeleton having a first cuff adapted to be coupled to a user's lower limb is disclosed. The exoskeleton also includes a second cuff adapted to be coupled to the user's upper limb and a third cuff adapted to be coupled to the user's body. A first motor is mounted on the third cuff and has a first motor output coupled to the first cuff. A second motor is mounted on the third cuff and has a second motor output coupled to the second cuff. A processor is operatively coupled to the first and second motors to manipulate the first cuff and the second cuff relative to the third cuff such that the first cuff and the second cuff are able to move the user's lower limb and upper limb. A method of operating the exoskeleton is also disclosed.
US08409115B2 Body composition measuring apparatus
A CPU (134) of a body composition measuring apparatus (100) drives a navel position indicator (118) so that it emits light. The height of a frame (114) is adjusted so that a beam of light from navel position indicator (118) irradiates the navel of a human subject. Plural sensors (106) are mounted on the frame (114), and each sensor measures a distance from the sensor to a position to be measured, whereby the abdominal width (X) of the human subject is determined. Subsequently, CPU (134) obtains measured values of weight (W) and bioelectrical impedance (Z). CPU (134) then reads an equation for calculating the visceral fat area and estimates the visceral fat area (Y) based on the measured abdominal width (X), weight (W), bioelectrical impedance (Z), and the equation.
US08409112B2 Specimen collection bag
A specimen collection bag includes a flexible bag with a bottom end and a mouth end. A sleeve extends around at least a portion of a perimeter of the mouth end. The sleeve is adapted to receive the jaws of a grasping tool that are movable between a closed position and an open position. Opening the jaws causes the mouth end of the specimen collection bag to open and closing the jaws causes the mouth end of the specimen collection bag to close.
US08409110B2 Thermal monitoring
A rectal thermal monitor for transrectal prostate temperature measurement includes a handle arranged in a proximal end portion of the monitor for gripping by a user, an elongate shaft extending from the handle, and a probe portion arranged on a distal end portion of the shaft. The probe portion is arranged at a position opposite the handle portion, and is shaped to facilitate insertion through an anal sphincter and into a rectum of a patient. A temperature sensing element is arranged within the distal probe portion and is adapted and configured to sense a temperature of the prostate of the patient through the rectum wall of the patient. The probe portion can include one or more compliant materials and/or be shaped so as to compress during insertion through the anal sphincter of the patient.
US08409108B2 Multi-axial heart sounds and murmur detection for hemodynamic-condition assessment
A vector method for monitoring a subject's hemodynamic condition including (a) utilizing at least one, external or internal, anatomy-attached, three-axis accelerometer, collecting from the subject, during a selected cardiac cycle, related, three-orthogonal-axes accelerometer signal data, (b) following such collecting, processing collected signal data to obtain associated, signal vector, magnitude and directionality information, and (c) analyzing such obtained vector information for assessment of the subject's heart hemodynamic condition. ECG and signal time-frequency data is also collected and used in certain manners and implementations of the invention.
US08409107B2 Tachyarrhythmia detection and discrimination based on curvature parameters
Estimating a frequency of a sampled cardiac rhythm signal and classifying the rhythm. The received signal is sampled and transformed into a curvature series. A lobe in the curvature series corresponds to a characteristic point in the sampled series. Characteristic points are selected based on a time of a lobe in the curvature series and, in one embodiment, an amplitude of the signal at the time of the lobe. A frequency of the sampled series is estimated by autocorrelating a function of the series of the characteristic points. In one embodiment, the function is a time difference function. The rhythm is classified by plotting the timewise proximity of characteristic points derived from an atrial signal with characteristic points derived from a ventricular signal. Regions of the plot are associated with a particular rhythm and the grouping of the data corresponds to the classification.
US08409106B2 Blood pressure measurement device for measuring blood pressure with clothes on
A sphygmomanometer (1) stores a parameter for calculating a blood pressure value from a measurement value with clothes on from a measurement value with clothes off at a measurement site and the measurement value with clothes on in advance. When a with-clothes mode is selected with a button (3-4) in measuring the blood pressure, the blood pressure value is calculated using the parameter stored with respect to the measurement value.
US08409099B2 Focused ultrasound system for surrounding a body tissue mass and treatment method
A focused ultrasound system includes an ultrasound transducer device forming an opening, and having a plurality of transducer elements positioned at least partially around the opening. A focused ultrasound system includes a structure having a first end for allowing an object to be inserted and a second end for allowing the object to exit, and a plurality of transducer elements coupled to the structure, the transducer elements located relative to each other in a formation that at least partially define an opening, wherein the transducer elements are configured to emit acoustic energy that converges at a focal zone.
US08409096B2 Breathing circuit with embedded acoustic reflectometer
An instrument may continuously monitoring acoustic reflections from within and/or beyond an intubation tube positioned within the mouth of a patient while the patient is breathing. The instrument may include an acoustic reflectometer configured to detect the acoustic reflections. An acoustic flow channel may contain the acoustic reflectometer within it. The acoustic flow channel may be configured to acoustically couple the acoustic reflectometer to an end of the intubation tube, but to substantially block the free flow of expiratory gas from the end of the intubation tube through the acoustic flow channel. A gas flow channel may be separate from the acoustic flow channel and may be configured to allow the free flow of expiratory gas from the end of the intubation tube through the gas flow channel.
US08409093B2 Assessing measures of glycemic variability
Methods, devices and systems for receiving an instruction to determine a glycemic variation level, retrieving a stored metric for determining the glycemic variation level, retrieving one or more parameters associated with the retrieved metric analysis, determining the glycemic variation level based on the retrieved one or more parameters for the retrieved metric analysis, and outputting the determined glycemic variation level when it is determined that the retrieved one or more parameters associated with the retrieved metric analysis meets a predetermined condition are disclosed.
US08409085B2 Surgical retention port and method of use
A surgical retention port particularly useful as an arthroscopic port for shoulder surgery is provided. The surgical retention port has an inner cannula defining a throughbore, a plurality of rotatable fingers coupled to the inner cannula, and an outer cannula extending around the inner cannula. Rotation of the inner cannula relative to the outer cannula causes the rotation of the fingers from a first position where the fingers assume a collapsed configuration to a second position where the fingers assume an extended or open configuration.
US08409083B2 Surgical access methods for use with delicate tissues
Surgical methods providing access to delicate tissue, such as brain tissue or breast tissue, through a transcutaneous incision. A method may include making an incision adjacent a region containing delicate tissue, and providing a surgical assembly having: a retractor having a hollow sleeve extending from a proximal end to a distal end, and an introducer having a proximal end installed within the hollow sleeve and a distal end extending beyond the distal retractor end. The surgical assembly is advanced into the region containing delicate tissue, and the distal introducer end gently displaces the delicate tissue as the surgical assembly is advanced to thereby avoid damage to the delicate tissue. The introducer is removed from the retractor to leave the distal retractor end at a surgical site located in the physical region containing delicate tissue. One or more surgical instruments are then used through the hollow sleeve.
US08409081B2 Illumination light application structure and endoscope provided with the same
An illumination light application structure provided for irradiating an observation object with illumination light in an observation optical apparatus provided with an objective optical system inside a lens barrel whose top is configured into a slender shape, includes a wavelength converting element located in the proximity of a position of an entrance pupil of the objective optical system; a light source emitting light whose wavelength is converted by the wavelength converting element; and an irradiation device irradiating the wavelength converting element with the light emitted from the light source through the objective optical system.
US08409080B2 Remote endoscope handle manipulation
Systems and methods permit remote endoscope handle manipulation. This can include a control housing configured to removably attach to an endoscope. A manipulator, associated with the housing, can be configured to engage with a control device of the endoscope with the endoscope attached to the housing. An actuator, drivingly coupled with the manipulator, can be configured to move the manipulator to operate the control device with the endoscope attached to the housing.
US08409078B2 Endoscope
An endoscope includes: an insert portion having a bending portion for bending operation and a flexible soft portion connected to the proximal end of the bending portion; an inflatable/deflatable balloon attached on the proximal side from the bending portion; and a supplying/sucking opening provided in the outer surface of a ring that connects the bending portion to the soft portion, the supplying/sucking opening supplying and sucking fluid to and from the balloon.
US08409077B2 Capsule endoscope
A capsule endoscope can prevent any fall of the efficiency of observation by reducing the substance or substances adhering to the outer surface of the front end cover such as food residue and mucus. The capsule endoscope includes a dome-shaped front end cover provided on the outer surface with photocatalytic coating, an image pickup means arranged in the front end cover to pick up images of the inside of an object of examination into which the endoscope is introduced and acquire image information on the inside of the object of examination and a lighting section arranged around the image pickup means within the dome-shaped front end cover.
US08409076B2 Device for laparoscopic or thoracoscopic surgery
A device (10) for laparoscopic or thoracoscopic surgery, the device (10) comprising: a first member (20) to be moved across the body (5) of a patient; and a second member (30) to be placed within the body (5), the second member (30) comprising an image capturing device (32) to capture images from within the body (5) and to transmit the captured images for display; wherein the second member (30) is in magnetic engagement with the first member (20) such that the movement of the second member (30) within the body (5) is in response to movement of the first member (20) across the body (5).
US08409072B2 Infant care apparatus
In an infant care apparatus according to this invention, the inner surface of an upper reflecting plate portion of a reflector forms a reflecting surface extending substantially parallel to the axial direction of a rod-like heat generator. A first angle at which a rear end of the reflecting surface as an end portion on a side opposite to the center of an infant mat, when seen from the top, of a direction perpendicular to the axial direction is bent downward with respect to a center in a back-and-forth direction of the reflecting surface, which is developed substantially flat, is larger than a second angle at which a front end of the reflecting surface as an end opposite to the rear end is bent downward with respect to the center of the reflecting surface. This invention can provide the infant care apparatus in which not only a heater need not be retracted to another location or need be only slightly when an infant on the mat is to undergo X-ray imaging of the like, but also in spite that the upper surface of the mat is substantially rectangular, the entire upper surface of the mat can be warmed substantially uniformly or almost uniformly.
US08409065B2 Bag manufacturing and packaging apparatus
A bag manufacturing and packaging apparatus is adapted to form a strip film into a cylindrical film. The bag manufacturing and packaging apparatus includes a sealing unit with a pair of sealing members facing each other to seal an end portion of the cylindrical film therebetween to package an article. Each of the sealing members includes a sealing jaw, a heating unit, and a heat insulating member. The sealing jaw has a heat generating surface, and configured and arranged to seal the cylindrical film on the heat generating surface. The heating unit is configured and arranged to heat the heat generating surface of the sealing jaw. The heat insulating member insulates the heat conduction from the heating unit to a direction other than a direction toward the heat generating surface of the sealing jaw.
US08409064B2 Method and device for making boxes from a set of blanks
This is a method and device for making a packaging box from two blanks (2, 3), wherein blanks are taken simultaneously from two adjacent stacks (25, 26) and placed on two parallel tracks (29, 30), the blanks are transferred flat until butted longitudinally to an assembly station, the first blank is glued on its way to the longitudinal abutment position, the first and second blanks are butted laterally into their respective positions to give them an exact lateral reference position, they are grasped, and transferred laterally, and the second blank is placed on the first blank which is thus indexed, escaping the drivers (61) of the first track (29) when the second blank is placed against the fast blank, but clamped by vertical pressure. The second blank is then applied to the first blank to glue them together in their respective defined longitudinal positions, and the resulting set of blanks is then transferred to an erecting station where the box is erected by rolling the blanks around a core.
US08409062B2 Machine tool
A machine tool has, on a machine bed, two stands which can be moved in the horizontal x- and z-direction, on which y-slides carrying tool spindles can be vertically moved. Arranged on one of the stands directly above a bridge projecting over its upper side is at least one tool magazine, with which a tool changer is associated for each stand. The drives for the y-slides are attached below the upper side of the stands to the stands.
US08409061B2 Hand held exercising device that is assembled solidly
An exercising device includes a main body having an elongate cord and a grip, and a weight unit adjustably mounted on the cord. The weight unit includes a connecting block mounted on the cord, and a weighting block mounted on the connecting block. The connecting block has a flexible tapered mounting post and has a mounting hole. The weighting block has a tapered pressing hole pressing the mounting post. Thus, the mounting hole of the connecting block encircles the cord completely so that when the mounting post is pressed toward the cord by the pressing hole of the weighting block, the connecting block compresses the cord tightly so as to lock the weight unit on the cord of the main body.
US08409059B2 Power assisted arm driven treadmill
Systems and methods for a treadmill or similar exercise device which utilizes a principally arm driven belt, but includes a motor assist which provides for additional drive to the belt. The motor assist device may constructively or destructively interact with the user provided motive force via the arms. Generally, the motor will allow for the device to utilize incline as well as to make the device easier to start from rest.
US08409055B2 Powertrain thermal management system
A thermal management system for a vehicle powertrain includes a heater core, a transmission fluid warmer selectively in thermal communication with the heater core, a bypass valve between the heater core and transmission fluid warmer configured to control fluid flow therebetween, a control module configured to control the bypass valve, and a timer linked to the control module configured to delay deactivation of the bypass valve.
US08409050B2 Gear retention assembly
A gear retention assembly for retaining a gear that has a plurality of gear outer splines includes a gear housing and a retaining ring. The gear housing has a first end, a second end, and a plurality of inner splines each including a ramp portion. The second end of the gear housing includes an annular continuous rolled lip, where the continuous rolled lip and the ramp portions of the plurality of inner splines define a groove. The plurality of inner splines engage with the gear outer splines of the gear to transmit torque between the gear and the gear housing. The retaining ring is disposed in the groove and axially retains the gear. The rolled lip axially retains the retaining ring.
US08409046B2 Multi-speed transmission with external drive gearsets
A transmission is provided having an input member, an output member, three planetary gear sets, two external gear sets or sprocket sets, a plurality of coupling members and a plurality of torque transmitting devices. Each of the planetary gear sets includes first, second and third members. Each of the external gear sets includes first and second members. The torque transmitting devices include clutches and brakes.
US08409040B1 Powertrain with two planetary gear sets and two motor/generators for hybrid vehicle
A powertrain includes an input member, an output member, and a stationary member. A first and a second electric motor/generator are provided. Only two planetary gear sets are used, each having a respective first, second, and third member. An interconnecting member connects one of the members of a first one of the planetary gear sets to one of the members of a second one of the planetary gear sets. The input member, the output member, the first motor/generator and the second motor/generator are each continuously connected for common rotation with a different one of the members of the planetary gear sets that is not connected by the interconnecting member. Four brakes are each selectively engageable to ground a different respective one of the members of the planetary gear sets that is not connected by the interconnecting member to the stationary member.
US08409039B2 Dual stage clutch
Continuously variable speed drive (CVT) have improved performance due to use of two groups of flyweight cams, each group being mounted on separate rotational members of a centrifugal clutch. One set of flyweight cams provides force to close the sheaves through the entire movement of the shift, whereas the other set of flyweight cams provides force only through an initial portion of the shift and then signs off. This provides a two stage shift behavior for the CVT that enhances power transfer to the driven pulley.
US08409028B2 Golf club head
An iron-type golf club head is disclosed including a main body including a heel portion, a sole portion, a toe portion, a top-line portion, a front portion, a rear portion, and a striking face. The main body has a recessed region including a relief region in the front portion. A replaceable striking plate is inserted into the recessed region and the relief region. The replaceable striking plate includes a front surface, a first rear surface region and a second rear surface region. A threaded opening is located on the rear surface of the replaceable striking plate and receives a fastener to retain the replaceable striking plate on the front portion of the main body and within the recessed region and relief region.
US08409026B2 Golf putter with trampoline-effect drumhead striking surface and pendulum plumb-bob peripheral weight distribution
An improved design for a golf putter has a putter head with a back surface formed in an elliptical shape elongated along a transverse axis normal to a swing plane for the putter, enclosing a hollow interior and having a circumferential rim forming an elliptical frame for the putter head. A head striking surface is formed with a sheet of taut, resilient material secured to the elliptical frame providing a trampoline-like drumhead effect when it makes contact with a golf ball that tends to return the ball's rolling trajectory to the target line of the swing axis even if contact is made off-center. The putter body is an elongated tubular body oriented in the direction of the swing axis, so that the peripheral weight of the putter is aligned along the swing axis and creates a pendulum plumb-bob effect of weight moving under gravity aligned in the swing direction. The front end of the tubular body is fitted through a central aperture in the back surface of the putter head and abuts the taut, resilient sheet material to form a circular “sweet spot” on the head striking surface.
US08409022B2 Iron-type golf club head or other ball striking device
A ball striking device, such as an iron-type golf club head, includes a face having a ball striking surface and a rear surface, and a body connected to the face. The body has a sole member and a rear cavity defined at least partially by the sole member and the rear surface of the face. The body has an elongated, recessed channel extending within the cavity along a juncture line between the rear surface of the face and the sole member. Additionally, the head is formed in part by a face member having a first leg forming at least a major portion of the face and a second leg extending rearwardly from a bottom end of the first leg and forming at least a portion of the sole member. The head may further be formed by a body member connected to the face member.
US08409020B2 Cross groove type constant velocity joint with composite groove patterns
A constant velocity joint for a drive system comprises: an outer joint member having a plurality of inwardly facing outer ball grooves, the outer ball grooves consisting of a first group of grooves and a second group of grooves with composite or non-linear groove pattern; an inner joint member disposed inside the outer joint member and having a plurality of outwardly facing inner ball grooves consisting of a first group of grooves and a second group of grooves with composite or non-linear groove pattern, each inner ball groove of the inner joint member being coupled with a corresponding outer ball groove of the outer joint member generally in crossed pair.
US08409019B2 Propeller shaft
A propeller shaft includes a first shaft having a yoke at one end, a second shaft slidably connected to the other end of the first shaft, and a surface treated member which is arranged at a connecting portion, at which the first shaft and the second shaft are connected to each other, and to which surface treatment for improving slidability of the second shaft with respect to the first shaft is applied. The surface treated member is formed by a substrate which is separate from the first shaft and the second shaft and to which the surface treatment has been applied. The surface treated member is arranged at the connecting portion, at which the first shaft and the second shaft are connected to each other, after the surface treatment is applied.
US08409014B2 Wagering game system with shared outcome determined by a gaming machine
A gaming system for playing a wagering game and a community event includes a first gaming machine and a second gaming machine. The first gaming machine determines a randomly selected community-event outcome for the community event, and sends information related to the outcome to at least one other gaming machine of the plurality of gaming machines. The second gaming machine receives the information from the first gaming machine and plays the community event.
US08409010B2 Massively multiplayer game with shared gameplay experience
According to some aspects of the present disclosure, a computing system for coordinating massively multiplayer games is provided. The computing system may include a data aggregation service to collect, aggregate and distribute game play data that is used by game code executed on each player's computing device to influence game flow of a shared game play experience for many thousands of remotely located players in real-time. Accordingly, game data from any player may impact and influence the game play experience of all other players. Further, each player's computing device may be event driven such that game data may be received from the game data aggregation service at a synchronized time to synchronize the shared game play experience for all players.
US08409007B2 Server apparatus and game system
In a game system, a server apparatus (3) that communicates with a plurality of game devices (1) stores play data elements for a plurality of players and public IDs for identifying a plurality of players in a latest play data table (T1) and a public ID table (T2). The server apparatus (3) transmits to a mobile terminal (4), which is being used by a player, information depending on latest play data elements stored in the latest play data table (T1), the latest play data elements belonging to other players who have been registered with the personal relationship table (T3) as a friend of the player possessing the mobile terminal (4). Upon receiving a public-ID-change request from a mobile terminal (4), which is being used by a player, the server apparatus (3) changes the public ID of the player stored in the public ID table (T2).
US08409000B1 Configuring advertisements in a video segment based on a game result
Configuration of advertisements in a streaming video segment from a serving node is based on a result of an interactive game process executing on a client device. A configuration of advertisements in the streaming video is determined based on the game result. The configuration may include which advertisements are selected to play during ad slots to be included in the video segment, or a number of ad slots to be provided in the video segment. The serving node may configure the video segment with the advertisements selected based on the game result in the determined number of ad slots so that the selected advertisements are played during the ad slots when the video segment is streamed to the client device. If the video segment is configured with no ad slots based on the game result, then the video segment may be streamed to the client device without advertisements.
US08408995B2 Game system, and jackpot drawing apparatus and game apparatus constituting the same
Where a drawing machine for jackpot game is utilized in a game system in which a plurality of game apparatuses are divided into a plurality of groups for management, a payout ratio is easily managed for each group.The drawing machine for jackpot game performs a group drawing for selecting one winning group among a plurality of groups and performs a winner determining process for determining a winner among players who play game apparatuses belonging to the winning group, thereby performing a jackpot drawing. Then, the drawing machine for jackpot game performs the group drawing in a manner that, among the plurality of groups, a particular group in which a total amount of an own group-specific jackpot balance amount obtained by deducting from a group-specific accumulated pool amount obtained by summing up for each group pool amounts of game apparatuses belonging to each group from a predetermined point in time a total amount from the predetermined point in time covering amounts of payout object paid out when a player who played a game apparatus belonging to the group concerned wins a jackpot award and an own group-specific maximum loss amount set for each group is equal to or more than a jackpot retention amount is not determined as a winning group.