最新美国发明专利第2013-02-26期 - 专利汇|PatentHub专利检索|专利查询网|发明专利查询分析

Document	Document Title
US08384097B2	Package for multiple light emitting diodes Substrates and packages for LED-based light devices can significantly improve thermal performance and provide separate electrical and thermal paths through the substrate. One substrate includes multiple electrically insulating base layers. On a top one of these layers are disposed top-side electrical contacts, including light device pads to accommodate a plurality of light devices. External electrical contacts are disposed on an exterior surface of the substrate. Electrical paths connect the top-side electrical contacts to the external electrical contacts. At least portions of some of the electrical paths are disposed between the electrically insulating base layers. The electrical paths can be arranged such that different subsets of the light device pads are addressable independently of each other. A heat dissipation plate can be formed on the bottom surface of a bottom one of the base layers.
US08384096B2	Semiconductor component with optically active regions which provides high optical output power, and method for producing same A semiconductor component comprising at least one optically active first region (112) for emitting electromagnetic radiation (130) in at least one emission direction and at least one optically active second region (122) for emitting electromagnetic radiation (130) in the at least one emission direction. The first region (112) is here arranged in a first layer (110) and the second region (122) in a second layer (120), the second layer (120) being arranged over the first layer (110) in the emission direction and comprising a first passage region (124) assigned to the first region (112), which first passage region is at least partially transmissive for the electromagnetic radiation (130) of the first region (112).
US08384092B2	Light emitting device A light emitting device that has excellent color rendering performance is provided.The light emitting device comprises, a light emitting element, a red phosphor formed from a nitride phosphor that emits light when excited by the light from the light emitting element, a green phosphor formed from a halosilicate that emits light when excited by the light from the light emitting element and a YAG phosphor emitting light when excited by the light from the light emitting element.
US08384091B2	Thin film light emitting diode Light emitting LEDs devices comprised of LED chips that emit light at a first wavelength, and a thin film layer over the LED chip that changes the color of the emitted light. For example, a blue LED chip can be used to produce white light. The thin film layer beneficially consists of a florescent material, such as a phosphor, and/or includes tin. The thin film layer is beneficially deposited using chemical vapor deposition.
US08384089B2	Nitride semiconductor device and method of manufacturing the same A nitride semiconductor device including: a substrate; a nitride semiconductor layer formed on the substrate and having a heterojunction interface; and a recess portion formed on the nitride semiconductor layer, wherein the nitride semiconductor layer includes: a carrier transit layer, which has a composition represented by the formula: Alx1Inx2Ga1−x1−x2N, (0≦x1≦1, 0≦x2≦1, 0≦(x1+x2)≦1); and a carrier supply layer including: a first layer formed on the carrier transit layer, said first layer having a composition represented by the formula: AlyGa1−yN, (0
US08384085B2	Semiconductor device and method for manufacturing the same An object is to provide a semiconductor device in which characteristics of a driver circuit portion are improved while the aperture ratio of a pixel portion is increased. Alternatively, it is an object to provide a semiconductor device with low power consumption or to provide a semiconductor device in which the threshold voltage of a transistor can be controlled. The semiconductor device includes a substrate having an insulating surface, a pixel portion provided over the substrate, and at least some of driver circuits for driving the pixel portion. A transistor included in the pixel portion and a transistor included in the driver circuit are top-gate bottom-contact transistors. Electrodes and a semiconductor layer of the transistor in the pixel portion have light-transmitting properties. The resistance of electrodes in the driver circuit is lower than the electrodes included in the transistor in the pixel portion.
US08384081B2	Semiconductor device The present invention is to provide a semiconductor device that achieves high mechanical strength without reducing the circuit scale and that can prevent the data from being forged and altered illegally while suppressing the cost. The present invention discloses a semiconductor device typified by an ID chip that is formed from a semiconductor thin film including a first region with high crystallinity and a second region with the crystallinity inferior to the first region. Specifically, a TFT (thin film transistor) of a circuit requiring high-speed operation is formed by using the first region and a memory element for an identifying ROM is formed by using the second region.
US08384075B2	Thin film transistor and method of fabricating the same A thin film transistor includes a multi-coaxial silicon nanowire unit including a plurality of coaxial silicon nanowires on a substrate, the multi-coaxial silicon nanowire unit including a central portion and end portions of the central portion; a gate electrode on the central portion; and a source electrode and a drain electrode on the respective end portions, respectively, so as to electrically connect to the multi-coaxial silicon nanowire unit.
US08384074B2	Heterocyclic compound and organic light-emitting device including the same A heterocyclic compound of formula 1 and an organic light-emitting device including an organic layer containing the heterocyclic compound. The heterocyclic compound of Formula 1 may be suitable as a material for an emission layer, an electron transport layer or an electron injection layer of an organic light-emitting device. Due to the inclusion of the heterocylic group in its molecular structure, the heterocyclic compound of Formula 1 may have a high glass transition temperature (Tg) or a high melting point, and may prevent crystallization. An organic light-emitting device manufactured using the heterocyclic compound of Formula 1, in which a chrysene group and an indole group are fused, has excellent durability when stored or operated.
US08384069B2	Semiconductor structure having blocks connected by nanowires A semiconductor structure includes a support and at least one block provided on the support. The block includes a stack including alternating layers based on a first semiconductor material and layers based on a second semiconductor material different from the first material, the layers presenting greater dimensions than layers such that the stack has a lateral tooth profile and a plurality of spacers filling the spaces formed by the tooth profile, the spacers being made of a third material different from the first material such that each of the lateral faces of the block presents alternating lateral bands based on the first material and alternating lateral bands based on the third material. At least one of the lateral faces of the block is partially coated with a material promoting the growth of nanotubes or nanowires, the catalyst material exclusively coating the lateral bands based on the first material or exclusively coating the lateral bands based on the third material.
US08384065B2	Gate-all-around nanowire field effect transistors A method for forming a nanowire field effect transistor (FET) device, the method includes forming a suspended nanowire over a semiconductor substrate, forming a gate structure around a portion of the nanowire, forming a protective spacer adjacent to sidewalls of the gate and around portions of nanowire extending from the gate, removing exposed portions of the nanowire left unprotected by the spacer structure, and epitaxially growing a doped semiconductor material on exposed cross sections of the nanowire to form a source region and a drain region.
US08384063B2	Light emitting device A light emitting device includes a stacked body including at least a light emitting layer made of Inx(AlyGa1-y)1-xP(0≦x≦1, 0≦y≦1), a p-type cladding layer made of Inx(AlyGa1-y)1-xP (0≦x≦1, 0≦y≦1), and a bonding layer made of a semiconductor; and a substrate in which deviation in a lattice constant at a bonding interface with the bonding layer is larger than deviation in lattice constants between the light emitting layer and the bonding layer. The p-type cladding layer is located more distant from the bonding interface than the light emitting layer, and the p-type cladding layer has a carrier concentration of 0.5×1017 cm−3 or more and 3×1017 cm−3 or less.
US08384061B2	Nonvolatile memory device and manufacturing method A nonvolatile memory device of the present invention includes a substrate (1), first wires (3), first resistance variable elements (5) and lower electrodes (6) of first diode elements which are filled in first through-holes (4), respectively, second wires (11) which cross the first wires 3 perpendicularly to the first wires 3, respectively, and each of which includes a semiconductor layer (7) of a first diode elements, a conductive layer (8) and a semiconductor layer (10) of a second diode elements which are stacked together in this order, second resistance variable elements (16) and upper electrodes (14) of second diode elements which are filled into second through holes (13), respectively, and third wires (17), and the conductive layer (8) of each second wires (11) also serves as the upper electrode of the first diode elements (9) and the lower electrode of the second diode elements (15).
US08384055B2	Output circuit, light-receiver circuit using the same, and photocoupler An output circuit includes a bias circuit that operates when a power supply voltage equal to or larger than a predetermined voltage is applied, a differential amplifier circuit that outputs signals according to input differential signals upon receiving a bias current or bias voltage generated when the bias circuit is operated, an output stage circuit that receives differential signals according to an output from the differential amplifier circuit and outputs output signals according to the differential signals, the output stage circuit having fewer number of stages of elements connected in series than the bias circuit, and a pull-down circuit that forcibly sets a level of one of the differential signals received by the output stage circuit to a ground voltage to fix the level of the output signals output from the output stage circuit when the bias current or the bias voltage generated by the bias circuit is not supplied.
US08384054B2	Multiplanar irradiation device with treatment beam directed opposite an access Irradiation device for proton and/or ion beam therapy, said device comprising a radiation source, a beam guiding device, and a therapy room comprising a treatment site and an access, wherein the therapy room is arranged in a first plane, and the treatment beam is directed into the therapy room from a second plane above or below the first plane, and oriented towards the treatment site so that the treatment beam is directed away from the access. In the therapy room, a shielding is provided, which is open towards the treatment site and associated with the entrance region of the treatment beam into the therapy room so that the access is arranged on the side of the shielding opposing the treatment site, and a labyrinth leading from the access to the treatment site is provided laterally offset to the treatment beam proceeding in the therapy room and to the shielding.
US08384051B2	Charged particle beam drawing apparatus and article manufacturing method using same The drawing apparatus of the present inventions includes a detector having a size for which the detector can simultaneously detect two adjacent charged particle beams among a plurality of charged particle beams, and configured to detect an intensity of a charged particle beam incident thereon. A controller is configured to perform a control of a position of the detector and a control of a blanking deflector array such that one of two adjacent charged particle beams is in a blanking state and the other is in a non-blanking state on the detector that is moved, and each of the plurality of charged particle beams becomes in a blanking state and a non-blanking state sequentially, to cause the detector to perform an output in parallel with the control, and to inspect a defect in each blanking deflector in the blanking deflector array based on the output.
US08384047B2	Fluorescence-based ultraviolet illumination A solution for managing illumination of an organism with ultraviolet light is provided. A set of ultraviolet fluorescence characteristics of the organism can be determined using fluorescence data for the organism. The set of ultraviolet fluorescence characteristics can be used to determine a set of target properties of the ultraviolet light. The set of target properties can be used to illuminate the organism with ultraviolet light. The illumination can be managed during growth of the organism, breeding of the organism, and/or maintenance of the organism after harvest.
US08384046B2	Non-invasive methods and apparatus for detecting insect-induced damage in a plant Lesions caused by insects feeding on plants are associated with the generation of regions of blue-green fluorescence in such as the cotton boll carpel wall and in the lint region. The present disclosure now provides methods and devices to rapidly and non-invasively detect and measure the insect-related fluorescence and relate the fluorescence generated to the likelihood of insect damage in a crop. In particular, the methods are related to stink bug damage in the cotton plant, but are also suitable for the detection of insect-related damage of any plant. The methods of detecting insect-induced damage in a target plant tissue may comprise exposing a target plant or a fragment thereof, to an ultraviolet or violet light; and detecting an ultraviolet light-induced fluorescence from the target plant or the fragment thereof, thereby indicating the presence of insect-related plant damage. Further provided are devices configured for the identification of insect-induced damage in a plant or a fragment thereof, comprising: a source of an ultraviolet or violet light, at least one light detector; an electronic system for converting an output electrical signal to a measurement of the intensity of fluorescent light detected by the detector; and an output system to convert the measurement of the intensity of the fluorescent light to an indicator for indicating that a target plant or fragment thereof has insect-induced damage.
US08384045B2	Minute particle analyzing device and method A minute particle analyzing device includes: a light source; a first condenser lens for condensing light from the light source to a first end of a multimode optical fiber; a second condenser lens for condensing the light emerging from a second end of the multimode optical fiber to a minute particle; and a detector for detecting light generated from the minute particle by the application of the light from the light source.
US08384044B2	Apparatus and method for reading fluorescence It is an objection of the present invention to provide a fluorescence reading apparatus in view of the influence of fluorescence derived from a fluorescence substance that is not involved with an interaction between a probe substance and a target substance.The above-mentioned problem is solved by a fluorescence reading apparatus 12 comprising an incidence angle adjusting means 10 for adjusting an incidence angle when light from a light source 7 is incident on a substrate 2; and a controller 11 that controls an amount of the incidence angle adjusted by the incidence angle adjusting means 10 and also comprises a means for receiving information on the incidence angle and information on the fluorescence intensities or fluorescence images at a plurality of incidence angles and obtaining the penetration depths of the evanescent fields with respect to the plurality of incidence angles from the information on the incidence angles; and a means for obtaining information on the fluorescence intensities in the obtained plurality of penetration depths.
US08384043B2	Plasmon filter A plasmon filter may include an element supportive of plasmon energy and having a plurality of openings through which a material may pass. A system includes a fluid filter supportive of evanescent energy, an evanescent field generator, a sensor, and/or other components. A corresponding method may include generating plasmons on the filter and exposing a material to the plasmon energy.
US08384036B2	Positron emission tomography (PET) imaging using scattered and unscattered photons Determining the position of a radioactive source in a PET system. Detecting a scatter coincidence event characterized by a full-energy photon detected at a first detector and partial-energy photon at a second detector. Measuring the arrival time difference between the partial energy photon and the full energy photon. Measuring the energy of the partial-energy photon. Determining a scattering point as a function of the position of the first detector, the position of the second detector, the energy of the partial-energy photon, the energy of an unscattered photon, the mass of a scattering electron, and the speed of light. Determining the position of a radioactive PET source along a line between the scatter point and the first detector as a function of the distance between scatter point and the first detector, the distance between scatter point and the second detector, and the measured time difference.
US08384034B2	Beta ray detector and beta ray reconstruction method A beta ray detector and a beta ray reconstruction method are capable of achieving consistently high detection efficiency of beta rays in a wider energy region compared to that of a conventional beta ray detector while enhancing energy resolution. The beta ray detector comprises an absorber scintillator disposed to face a subject emitting beta rays and that is made from an absorptive substance exhibiting a high permeability and a high rate of absorption with respect to beta rays, a backscattering scintillator disposed on the backside of the absorber scintillator and that is made from a backscattering substance exhibiting a low permeability and a high rate of backscattering with respect to beta rays, and an energy detector that combines the amounts of beta ray energy absorption simultaneously measured by the two types of scintillators to reconstruct the energy and detection position of the beta rays emitted from the subject.
US08384033B2	Quantification of an absorber through a scattering medium There is described a method for determining a quantitative parameter of a compound in an analysis sample, comprising: providing a scattering medium in physical contact with the analysis sample, the scattering medium having at least one layer, an index of refraction of the scattering medium being superior to an index of refraction of the analysis sample; propagating, in the scattering medium, an incident beam of light having a wavelength substantially corresponding to an absorption wavelength of the compound such that an evanescent wave is generated at an interface between the scattering medium and the analysis sample; taking n intensity measurements of a reflected beam of light for the analysis sample, n being superior to one; and determining the quantitative parameter of the compound using the n intensity measurements for the analysis sample.
US08384030B2	Method and apparatus for setting sample observation condition, and method and apparatus for sample observation A method and apparatus for setting a sample observation condition and a method and apparatus for sample observation which allow sample observation by speedily and simply finding an optimum condition while suppressing damage to the sample are provided. The setting of a sample observation condition according to the present invention is realized by an electron beam apparatus acquiring a profile at a predetermined evaluation location of a sample under a reference observation condition, by a processing section judging whether or not the above described acquired profile is located within a predetermined setting range and setting an optimum observation condition to be used for sample observation based on this judgment result. More specifically, locations where the condition can be examined are registered beforehand first and then a jump is made to the corresponding location which is irradiated with an electron beam (hereinafter referred to as “predosing”) at a low magnification, the surface of the sample is charged, enlarged to an observation magnification and secondary electron information on the target location is obtained. After that, secondary electron information is obtained at any time while performing predosing, it is successively judged from the information whether the pattern bottom part can be observed/measured or whether or not the sample is destroyed and an optimum observation condition is thereby found.
US08384024B2	Tandem differential mobility spectrometers and mass spectrometer for enhanced analysis The invention relates generally to systems, methods and devices for analyzing samples and, more particularly, to systems using a differential mobility spectrometer in combination with a mass analyzer to enhance the analysis process of constituents of a sample.
US08384023B2	Post-ionization of neutrals for ion mobility oTOFMS identification of molecules and elements desorbed from surfaces The present invention relates to a method and apparatus for ionizing a neutral MALDI desorption plume, and in particular, for efficiently measuring the ionized MALDI desorption plume when post-ionization techniques are combined with a medium pressure MALDI-IM-oTOFMS instrument. Additionally, the present disclosure provides a method and apparatus that simultaneously separates tissue-sample MALDI ions by IM-oTOFMS according to their chemical family. After separation, the MALDI ions are directly compared to the ions created by post-ionizing the co-desorbed neutral molecules with a second laser wherein the second laser is delayed by a few hundred microseconds. The present disclosure further provides novel approaches that enhance the analysis of ions, including the use of giant fullerene internal standards to enhance mass accuracy, and ultraviolet (UV) declustering lasers to generate intact peptides and proteins, either of which may be followed by VUV post-ionization which generates identifiable structural fragments.
US08384021B2	Method of forming mass image An object of the present invention is to provide a method of comprehensively visualizing a constituent in tumor tissue or the like at a cellular level.The present invention provides a method of forming a two-dimensional distribution image of a target constituent based on information on the mass of constituents of the tissue section wherein, as the internal standard material, any one of actin, tubulin and GAPDH is used in the intracellular region, one of histone and nucleic acid is used in the nuclear region, and one of albumin and cytokine is used in the extracellular region.
US08384018B2	Increase of neutron flux with gamma shielding An analyzer having a detector and a neutron source assembly adjacent to the detector is disclosed, wherein the neutron source assembly has a neutron source and a shielding source holder.
US08384016B2	Stabilization in gamma-ray spectometry A calibration source comprises a radioactive material comprising a radioactive isotope having a decay transition associated with emission of a radiation particle and gamma-rays having a known energy and a solid-state detector, arranged to receive radiation particles emitted from the radioactive material. A gating circuit is coupled to the solid-state detector and is operable to generate a gating signal in response to detection of a radiation particle in the solid-state detector. The gating signal may thus be used as an indicator that an energy deposit in a nearby gamma-ray spectrometer is associated with a decay transitions in the radioactive isotope. Since these energy deposits are of a known energy, they can be used as reference points to calibrate the spectrometer response. Thus with calibration sources according to embodiments of the invention, spectral stabilization may be performed in real time and in parallel with obtaining a spectrum of observed signal events.
US08384015B2	Calibration source and methods for calibrating a nuclear medicine imaging system Systems and methods for calibrating a nuclear medicine (NM) imaging system are provided that include an NM calibration source. The NM calibration source includes an isotope source having an energy spectrum with at least one energy peak and a fluorescence layer adjacent the isotope source creating at least one additional energy peak in the energy spectrum.
US08384013B2	Optical filter An optical filter includes a light-shielding conductive layer provided with a plurality of apertures on a substrate surface that selectively transmits light of a first wavelength, and a dielectric layer in contact with the conductive layer. A size of the apertures is a size equal to or less than the first wavelength, and a ratio of a surface area of the conductive layer to a surface area of the substrate surface is within a range of equal to or greater than 36% and equal to or less than 74%. A transmissivity of the first wavelength is increased by surface plasmons induced in the apertures by light falling on the conductive layer.
US08384012B2	Photodiode comprising polarizer A photodiode includes a photosensitive area and a polarizing grating located in front of the photosensitive area. The polarizing grating is formed by a plurality of galvanically conducting filaments.
US08384008B2	Solid state imaging device to reduce power consumption A solid state imaging device comprises a pixel unit, a first controller, and a second controller. The pixel unit has a two dimensional matrix of pixels and each of the pixels is arrayed in the matrix. The first controller independently controls the output unit row by row. The second controller independently controls the first reset unit row by row. The each of pixels comprises a photoelectric conversion element, a first reset unit, a charge retention unit, a transmitter, a second reset unit, and an output unit. The element converts incident light into a signal charge and accumulates the converted signal charge. The first reset unit resets the signal charge. The charge retention unit retains a signal charge output from the photoelectric conversion element. The transmitter transmits the signal charge to the charge retention unit. The second reset unit resets the signal charge. The output unit outputs a pixel signal in response to the signal charge to a vertical signal line.
US08384007B2	Nano wire based passive pixel image sensor An imaging device including a plurality of photo-sensitive elements suitable for imaging small objects less than 500 nm in size. Each of the photo-sentive elements forms a passive pixel which comprises at least one nanowire structured photodetector and a switch transistor. The nanowire structured photodetector is configured to receive the photons and store the photo generated charges and behave as a waveguide. The switch transistor is formed either in the substrate or at the same body of the nanowire and is configured to allow photo-genereated charges in the nanowire to accumulate when off and to drain from the nanowire when on. The pixel array is configured to allow high resolution imaging by arranging in a penny round pattern.
US08384002B2	Multi-focal intraocular lens system and methods The invention pertains to methods, components, and operations of multi-focal intraocular lens systems, including range finding for driving same and for discriminating between multiple objects and varying brightness conditions. The invention also pertains to intraocular photosensors and range-finding methods to be used with intra-ocular lens systems, and components, that provide multi-focal IOL capabilities in dynamic visual environments.
US08384001B2	Microwave oven and reciprocating tray apparatus thereof Disclosed herein is a microwave oven, in which a tray within a cooking room is rectilinearly reciprocated in a lengthwise direction of the cooking room and is rotated, simultaneously, to cook food. This is achieved using a gear assembly including a main gear and a planetary gear. The gear assembly includes the main gear and the planetary gear, which are engaged with each other and are rotated. A diameter of the main gear and a diameter of the planetary gear may be equal to each other, and the main gear and the planetary gear respectively include eccentric shafts. The gear assembly effectively transmits power supplied by a motor to the tray, thereby allowing the tray to be rotated at a uniform speed and to be driven even using a motor having a small load capacity.
US08383998B1	Tooling inserts for laminated tooling An apparatus may comprise a first tool die and a second tool die, each having a tool base. Each tool base may have a laminated structure that has a plurality of spaced metallic laminations. The laminated structure may have a truncated portion forming a cavity configured to receive a tool insert, and at least one opening for receiving an induction coil. The first tool die and the second tool die may also have a tool insert configured to be received in the cavity of the tool base. The tool insert may have a die susceptor capable of being heated by the induction coil. The apparatus may also have an actuator for moving the first tool die and the second tool die toward one another for forming a component between the die susceptor of the tool insert of the first tool die and the die susceptor of the tool insert of the second tool die.
US08383997B2	Heated planar element and method for its attachment A double-sidedly bondable planar element which has an electrical contacting layer via which it is self-regulatingly intrinsically heatable and at the same time has a high flexibility. The particular features of this planar element are that the planar element in the storage condition is adhesive on one side only, and is therefore particularly easy to handle, and that, on bonding, the adhesive passes through cutouts in the contacting layer, and the planar element thus becomes double-sidedly bondable. The invention further provides a method for the bonding of this planar element, including as a key step the passage of the adhesive through the cutouts in the contacting layer, thus turning a single-sidedly adhesive planar element into a double-sidedly adhesive planar element.
US08383995B2	Flexible hot plate and cooking unit The invention provides a flexible hot plate and cooking unit, with a temperature differential of at least 40° C. between the two sides of the unit comprising a heating element sandwiched between an upper and a lower layer of flexible material wherein said upper layer provides a temperature along its upper surface of at least 80° C. for heating an object placed thereon, and said lower layer is provided with a plurality of insulating air passages.
US08383993B2	Temperature control device of electric heater using thermo-sensitive resin and safety device thereof A temperature control device is disclosed that includes a heating wire being connected to an alternating current power source though a SCR, a sensing wire being disposed parallel to the heating wire, a thermo-sensitive resin insulating the heating wire and the sensing wire from each other and changing its impedance according to a change in temperature, and a temperature sensing unit outputting a temperature control signal to turn the SCR on or off according to a change in electric current flowing through the thermo-sensitive resin, in which the SCR is turned on or off by a sensing unit diode. The heating wire is heated by a heating current that flows in a heating cycle only, in which a forward voltage is formed in the SCR, and the sensing wire conducts a sensing current that flows in a sensing cycle only, in which a reverse voltage is formed in the SCR.
US08383990B2	Substrate transport apparatus and heat treatment apparatus A chilled arm that transports a substrate to and from a heating plate for performing a heating process on the substrate is formed with a flow passage pipe therein, and cools the entire holding area thereof opposed to the substrate held by the chilled arm to a predetermined reference temperature by supplying circulating cooling water through the flow passage pipe. Six polyimide heaters are affixed to the holding area to control the temperature of at least a portion of the holding area at a temperature different from the reference temperature. These two temperature control mechanisms intentionally provide a temperature distribution to the holding area to thereby provide an intentional temperature distribution to the substrate before and after the heat treatment by the heating plate. This reduces the nonuniformity of a temperature distribution which typically occurs in the heating plate to accomplish a uniform heat treatment throughout the heat treatment process step.
US08383985B2	System and method for an integrated additive manufacturing cell for complex components An integrated additive manufacturing cell (IAMC) that combines conventional manufacturing technologies with additive manufacturing processes is disclosed. Individual IAMCs may be configured and optimized for specific part families of complex components, or other industrial applications. The IAMCs incorporate features that reduce hardware cost and time and allow for local alloy tailoring for material properties optimization in complex components.
US08383984B2	Method and apparatus for laser singulation of brittle materials An improved method for singulation of electronic substrates into dice uses a laser to first form cuts in the substrate and then chamfers the edges of the cuts by altering the laser parameters. The chamfers increase die break strength by reducing the residual damage and removes debris caused by the initial laser cut without requiring additional process steps, additional equipment or consumable supplies.
US08383983B2	Substrate cutting apparatus and method of cutting substrate using the same A substrate cutting apparatus including: a stage to support a substrate; a laser generator to emit a laser beam; a beam oscillator to oscillate the laser beam onto a cutting line of the substrate, to heat the substrate; and a cooling unit to cool the heated substrate.
US08383980B2	Laser processing machine having programmable focus positioning function A laser processing unit includes a torch that is automatically mounted on a processing head. The torch has an assist gas chamber and a balance chamber, and the assist gas is supplied to the chambers. Constantly, equal pressures act on the both chambers, and an upward first force and a downward second force that act on a lens holder offset each other because pressure reception areas are equal. Gas is supplied to a gas spring chamber to provide a constant upward force to the lens holder. A driving device has an arm driven by a servomotor. The arm is in contact with a pin and the lens holder is moved to a predetermined position for automatically adjusting a focus position FC of a collective lens.
US08383976B2	Switch with electrical member supported in elastic folded contact A switch at least comprises a housing, an electrical member, a terminal and a connecting contact. The housing defining a cavity that includes two opposite sidewalls, and a pair of fixing grooves each defined by said sidewall and an extension wall spaced from said sidewall. The electrical member having a pair of leads disposed within said cavity. The terminal retained in the housing and having a contact portion abutting against said sidewall. The connecting contact retainably disposed within each said groove, and the connecting contact has a plate base abutting against said extension wall, a fixing portion attached onto an upper end of the plate base for clamping each said lead of the electrical member, and an spring portion reversely extending from an opposite bottom end of the plate base and designed to mechanically and electrically engage the contact portion of the second terminal.
US08383972B2	Illuminated keyboard An illuminated keyboard includes keys; a spacer board on a base plate and comprising units each including two first groove connectors and two second groove connectors; an optically transmissive film circuit board on the spacer board and comprising a second circuitry, switch contacts, and first holes each with the first or second groove connector passing; a rubber plate of optically transmissive plastic and on the film circuit board, the rubber plate comprising resilient domes having a recessed top for retaining the key, a conductive bottom stem above the switch contact, and second holes grouped as groups each formed as four corners around the dome, the first or second groove connectors adapted to pass through the second holes; and an LED circuit board on the rubber plate and comprising a first circuitry and LEDs electrically connected to the first circuitry to be powered therefrom.
US08383969B2	Apparatus including a circuit breaker retaining mechanism for use in withdrawable circuit breakers and method of operating the same A draw-out type circuit breaker apparatus is provided and includes a base from which a circuit breaker is selectively dismounted and moved along a first portion of a dismounting path into a disconnected position, a plate, fixed to the base, which is configured to guide the movement of the circuit breaker along the dismounting path, and a toggle link, coupled to the plate and biased to remain in a locking position, which is configured to block the circuit breaker from moving along the dismounting path beyond the disconnected position while the toggle link remains in the locking position, and to cause the circuit breaker to freely move from the disconnected position and along a second further portion of the dismounting path upon a temporary defeat of the bias thereof.
US08383968B2	Lever switch for safe breaking of a circuit of an exercise apparatus A lever switch for safe breaking of a circuit of an exercise apparatus includes two conductive copper pieces spaced apart and stably received within a housing by means of elastic pieces. A rotatable cylinder with two journals is positioned in the area of the contact portions of the conductive copper pieces within the housing. Moreover, a rectangular piece is provided at one side of the rotatable cylinder such that the contact portions of the conductive copper pieces are just clampable to the top and bottom ends of the rectangular piece. In addition, the middle portion of the conductive copper pieces is inwardly bent to form corresponding conductive contact surfaces. As a result, an insertion lever may fit into the body of the rotatable cylinder for in-place-moving the rotatable cylinder such that the rectangular piece is turned to bring the conductive contact surfaces of the conductive copper pieces in an electric disconnection or connection state for safe breaking and making of a circuit.
US08383965B2	Top-pan balance with an overload safety mechanism and a corner load sensor A top-pan balance having a pan, a weighing system, and an overload safety mechanism. The load cell (4) of the weighing system is connected to fixed points (1) on a housing of the weighing system by an upper connecting rod (2) and a lower connecting rod (3) as a parallel guide so as to be movable in the vertical direction. The pan is attached to a pan support (8/9) for securing against overload, the support being connected to the load cell through an auxiliary parallel guide (15/16) and through a biased spring element (17/18), whereby the pan is quasi rigidly coupled to the load cell in the permissible weighing range, but is only resiliently coupled to the load cell when the permissible weighing range is exceeded. At least one limit stop is fixed to the housing and limits the elastic deflection of the pan and the pan support in case of overload. An additional corner load sensor is provided between the pan support and the load cell, and the corner load sensor and the overload safety mechanism form a common assembly (7), wherein the corner load sensor is disposed behind the overload safety mechanism in the force flow direction from the pan to the load cell. Furthermore, the assembly is attached on the side of the load cell facing the connecting rods and extends into the space between the connecting rods.
US08383960B2	One-piece board level shielding with peel-away feature A one-piece board level shielding element with a top cover peel panel is secured to a circuit board to shield and provide access to a shielded component. The shielding element is formed with a top having a peel line to facilitate removal of the peel panel with a peel tool. Once the repair is completed, a new cover is put on to the remaining side-walls to reestablish the shielding. The shield top cover is formed with a peel tool insertion slot and an adjacent peel start slot. The peel panel is removed by a peel tool having a peel hook mounted to a cylindrical peel key that is inserted into the insertion slot and hooks the cover at the peel start slot. Upon rotating the peel key away from the peel start slot, the peel panel is easily removed. A fixture plate may be used to support the peel tool and assist in removal of the peel panel.
US08383958B2	Method to build robust mechanical structures on substrate surfaces A robust mechanical structure is provided to prevent small foundation structures formed on a substrate from detaching from the substrate surface. The strengthened structure is formed by plating a foundation metal layer on a seed layer and then embedding the plated foundation structure in an adhesive polymer material, such as epoxy. Components, such as spring probes, can then be constructed on the plated foundation. The adhesive polymer material better assures the adhesion of the metal foundation structure to the substrate surface by counteracting forces applied to an element, such as a spring probe, attached to the plated foundation.
US08383957B2	Printed circuit board A printed circuit board (PCB) includes two layers, two signal transmission traces, and a vertical interconnect access (via). The signal transmission traces are respectively arranged on the layers. The signal transmission traces are electrically connected to each other through the via. A centerline of the via with a vertical line of the layers form an acute angle θ, the angle θ is less than cos−1[(Lv2−Lt2)/(Lv2+Lt2)]. Wherein Lt is loss of the two signal transmitting traces in a unit length, and Lv is loss of the via in a unit length.
US08383954B2	Warpage preventing substrates Consistent with an example embodiment, there is an apparatus comprising a circuit (500) board. The circuit board includes a first surface (501a) and a second surface (501b). The first and second surfaces each have at least a component populated thereon; the circuit board has a first surface thereof populated before a second surface thereof and is overmolded. The circuit board has conductive material disposed over areas of the second surface defining at least a feature (504) on the second surface. The at least a feature is defined by the conductive material and other than defined by solder resist (508) disposed on the second surface overlapping the conductive material, wherein the at least a feature is a feature for remaining exposed during a process of populating the first surface other than a fiducial.
US08383951B2	Matched-impedance connector footprints Disclosed are methodologies for defining matched-impedance footprints on a substrate such as a printed circuit board, for example, that is adapted to receive an electrical component having an arrangement of terminal leads. Such a footprint may include an arrangement of electrically-conductive pads and an arrangement of electrically-conductive vias. The via arrangement may differ from the pad arrangement. The vias may be arranged to increase routing density, while limiting cross-talk and providing for matched impedance between the component and the substrate. The via arrangement may be altered to achieve a desired routing density on a layer of the board. Increasing the routing density may decrease the number of board layers, which tends to decrease capacitance and thereby increase impedance. Ground vias and signal vias may be arranged with respect to one another in such a manner as to affect impedance. Thus, the via arrangement may be altered to achieve an impedance that matches the impedance of the component. The via arrangement may be also be altered to limit cross-talk among neighboring signal conductors. Thus, the via arrangement may be defined to balance the impedance, cross-talk, and routing density requirements of the system.
US08383949B2	Method to form lateral pad on edge of wafer Embodiments are directed to an apparatus and fabrication method to form pad arrays on the edge of a substrate wafer substrate. Embodiments of the invention make it possible for surface mount devices to be bonded vertically (i.e. on their side) using standard semiconductor assembly processes.
US08383945B2	Dead end connector A dead end connector member including a shaft section and a clevis section. The shaft section includes a ridge section, wherein the ridge section is sized and shaped to have an outer sleeve compressed thereon to connect the outer sleeve to the shaft section. The clevis section has a front end connected to the shaft section. The clevis section includes two spaced legs forming an eyebolt receiving gap between the legs. Each leg comprises a pin hole adapted to receive a fastener to rotatably connected the dead end connector to an eyebolt of another member. The clevis section includes a tab at a rear end of the clevis section. The tab extends at least partially across the gap to form a rotation limiter adapted to contact one side of the eyebolt and limit rotation of the dead end connector member relative to the eyebolt in only one direction.
US08383944B2	Metal fitting integration type stress-relief cone and a cable sealing end using the same A metal fitting integration type stress-relief cone is provided with a stress-relief cone which includes a cylindrical rubber-like elastic body on an outer circumference of a cable core and a metal fitting which surrounds the cable core and is integral with a low-voltage side of the stress-relief cone. The stress-relief cone is provided with a cylindrical semi-conducting body part at the low-voltage side and has a bell-mouthed electric-field stress-control part in an end of a high-voltage side, an insulating body part on the high-voltage side with a low-voltage side end concentric with the semi-conducting body part and a cylindrical insulation protective layer which is arranged continuously at the end of the low-voltage side of the insulating body part and is integral with the outer circumference of the semi-conducting body part.
US08383940B2	Bus bar attaching member and room lamp for vehicle having bus bar attaching member A bus bar attaching member 1 forming a room lamp 10 for a vehicle includes a housing 2 and a plurality of bus bars 3a, 3b, 3h and 3i insert molded in the housing 2. Further, in wiring parts 5 of the bus bars 3a and 3b, impact absorbing parts 6a and 6b are provided that prevent an impact when an electric wire 8 is pressed in contact with pressure contact parts 4 from being transmitted to parts attaching parts 7. The impact absorbing parts 6a and 6b are configured in U shaped forms by first absorbing parts 61a and 61b extending in the directions intersecting virtual straight lines K1 and K2 that connect bottom walls 40 of the pressure contact parts 4 to the parts attaching parts 7, second absorbing parts 62a and 62b and third absorbing parts 63a and 63b.
US08383934B2	Electrical junction box An electrical junction box having a in which a plurality of connecting bolts are juxtaposed on a bolt support section and that exerts excellent strength to realize a reinforcing structure without interfering with mounting of a connecting plate onto the connecting bolts. Inserting slits are provided in a peripheral wall and a proximal end of a partition wall. A connecting plate is previously disposed through the slits on one surface of a bolt support section. A plurality of connecting bolts are attached to the bolt support section so that the bolt support section bridges the plural connecting bolts.
US08383932B2	Compound for organic photoelectric device and organic photoelectric device including the same A compound for an organic photoelectric device, represented by the following Chemical Formula 1:
US08383924B2	Musical tone signal generating apparatus A CPU 19a supplies parameters on musical tone signals to a tone generator 17 having a plurality of tone generation channels CH0, CH1, . . . , CH127 each generating a musical tone signal. The parameters include channel information which designates one or more of the tone generation channels, and musical tone information which defines respective musical tone signals which are to be generated in the respective tone generation channels designated by the channel information. The tone generator 17 has a tone generation reservation circuit 17b which makes the designated tone generation channels start generation of the musical tone signals defined by the musical tone information when the respective tone volume levels of musical tone signals currently generated in the tone generation channels designated by the channel information are equal to or below a certain tone volume level.
US08383922B1	Device for controlling picking depth for a stringed instrument An accessory for attachment to a stringed musical instrument that mechanically limits depth of picking action by providing interference to the finger, fingernail, or pick. A plate or “anvil” either flexible or rigid, is adjustably positioned beneath the strings to intercept and arrest a picking element. In a first embodiment, picking depth is roughly controlled my manually forcing the anvil up and down on a flanged support post. In a second embodiment, picking depth may be finely controlled by a knurled thumbwheel or similar mechanism on the anvil support posts. The flexibility of the plate provides a shock absorber, thereby creating a realistic feel to the player. The flexible plate assures both limitation of depth of picking action, and also renders picking action consistent as to depth.
US08383920B2	Keyboard apparatus A keyboard apparatus includes a key supported for pivoting movement about a pivot point, a mass member for imparting a reaction force to performance operation of the key in interlocked relation to the key, a transmission member provided in abutment with both of the key and mass member to transmit a load from one of the key and mass member to the other, and an electromagnetic actuator for driving, via a fixed coil, the transmission member toward at least one of the key or mass member. Good key touch feeling can be achieved not only by a load applied from the mass member to the key but also through load control by the actuator. Thus, it is possible to faithfully reproduce a key touch feeling approximate to that in a natural keyboard instrument, such as an acoustic piano, with a simple construction and facilitated control.
US08383919B2	Highly fluorescent peptide-metallic nanoclusters as bio-probes and methods of synthesis thereof A method of one reaction step for synthesis of peptide template fluorescent metal nanoclusters as bioprobes. Specific targeting peptide containing a metal reactive group is synthesized and used to react with a metal salt solution under a sufficient pH condition at room temperature in forming peptide template fluorescent metal nanoclusters. The dialyzed metal nanoclusters is used directly as bio-probes.
US08383918B2	Wheat variety 25R34 A wheat variety designated 25R34, the plants and seeds of wheat variety 25R34, methods for producing a wheat plant produced by crossing the variety 25R34 with another wheat plant, and hybrid wheat seeds and plants produced by crossing the variety 25R34 with another wheat line or plant, and the creation of variants by mutagenesis or transformation of variety 25R34. This invention also relates to methods for producing other wheat varieties or breeding lines derived from wheat variety 25R34 and to wheat varieties or breeding lines produced by those methods.
US08383913B1	Maize variety hybrid X85A661 A novel maize variety designated X85A661 and seed, plants and plant parts thereof, produced by crossing Pioneer Hi-Bred International, Inc. proprietary inbred maize varieties. Methods for producing a maize plant that comprises crossing hybrid maize variety X85A661 with another maize plant. Methods for producing a maize plant containing in its genetic material one or more traits introgressed into X85A661 through backcross conversion and/or transformation, and to the maize seed, plant and plant part produced thereby. This invention relates to the maize variety X85A661, the seed, the plant produced from the seed, and variants, mutants, and minor modifications of maize variety X85A661. This invention further relates to methods for producing maize varieties derived from maize variety X85A661.
US08383909B1	Maize variety hybrid X08A117 A novel maize variety designated X08A117 and seed, plants and plant parts thereof, produced by crossing Pioneer Hi-Bred International, Inc. proprietary inbred maize varieties. Methods for producing a maize plant that comprises crossing hybrid maize variety X08A117 with another maize plant. Methods for producing a maize plant containing in its genetic material one or more traits introgressed into X08A117 through backcross conversion and/or transformation, and to the maize seed, plant and plant part produced thereby. This invention relates to the maize variety X08A117, the seed, the plant produced from the seed, and variants, mutants, and minor modifications of maize variety X08A117. This invention further relates to methods for producing maize varieties derived from maize variety X08A117.
US08383907B1	Maize variety hybrid X03A184 A novel maize variety designated X03A184 and seed, plants and plant parts thereof, produced by crossing Pioneer Hi-Bred International, Inc. proprietary inbred maize varieties. Methods for producing a maize plant that comprises crossing hybrid maize variety X03A184 with another maize plant. Methods for producing a maize plant containing in its genetic material one or more traits introgressed into X03A184 through backcross conversion and/or transformation, and to the maize seed, plant and plant part produced thereby. This invention relates to the maize variety X03A184, the seed, the plant produced from the seed, and variants, mutants, and minor modifications of maize variety X03A184. This invention further relates to methods for producing maize varieties derived from maize variety X03A184.
US08383904B1	Maize variety hybrid X18A645 A novel maize variety designated X18A645 and seed, plants and plant parts thereof, produced by crossing Pioneer Hi-Bred International, Inc. proprietary inbred maize varieties. Methods for producing a maize plant that comprises crossing hybrid maize variety X18A645 with another maize plant. Methods for producing a maize plant containing in its genetic material one or more traits introgressed into X18A645 through backcross conversion and/or transformation, and to the maize seed, plant and plant part produced thereby. This invention relates to the maize variety X18A645, the seed, the plant produced from the seed, and variants, mutants, and minor modifications of maize variety X18A645. This invention further relates to methods for producing maize varieties derived from maize variety X18A645.
US08383902B2	Plants and seeds of hybrid corn variety CH999541 According to the invention, there is provided seed and plants of the hybrid corn variety designated CH999541. The invention thus relates to the plants, seeds and tissue cultures of the variety CH999541, and to methods for producing a corn plant produced by crossing a corn plant of variety CH999541 with itself or with another corn plant, such as a plant of another variety. The invention further relates to genetic complements of plants of variety CH999541.
US08383901B2	ODP1-2 genes and uses thereof in plants Methods are provided for altering plant characteristics by introducing into plants, isolated nucleic acid molecules that can be used to produce transgenic plants characterized by altered oil levels within the seed. Also provided are isolated nucleic acids that encode AP2 domain transcription factor proteins and fragments thereof, vectors capable of expressing such nucleic acid molecules, host cells containing such vectors, and polypeptides encoded by such nucleic acids.
US08383898B2	Soybean variety A1023788 The invention relates to the soybean variety designated A1023788. Provided by the invention are the seeds, plants and derivatives of the soybean variety A1023788. Also provided by the invention are tissue cultures of the soybean variety A1023788 and the plants regenerated therefrom. Still further provided by the invention are methods for producing soybean plants by crossing the soybean variety A1023788 with itself or another soybean variety and plants produced by such methods.
US08383894B2	Soybean variety A1023199 The invention relates to the soybean variety designated A1023199. Provided by the invention are the seeds, plants and derivatives of the soybean variety A1023199. Also provided by the invention are tissue cultures of the soybean variety A1023199 and the plants regenerated therefrom. Still further provided by the invention are methods for producing soybean plants by crossing the soybean variety A1023199 with itself or another soybean variety and plants produced by such methods.
US08383886B2	Genes encoding a novel type of lysophophatidylcholine acyltransferases and their use to increase triacylglycerol production and/or modify fatty acid composition Described nucleic acid molecules (and corresponding peptides) encode lyso-phosphatidylcholine (LPC) acyltransferases. Over-expression of the LPC acyltransferases in a cell may lead to enhanced production of PUFA, or other unusual fatty acids, and/or to increased oil content in the cell.
US08383872B2	Multiphase reaction process using microchannel technology The disclosed invention relates to a process for conducting a multiphase reaction in a microchannel. The process comprises: forming a multiphase reaction mixture comprising a first reactant and a second reactant; the first reactant comprising at least one liquid; the second reactant comprising at least one gas, at least one liquid, or a combination of at least one gas and at least one liquid; the first reactant forming a continuous phase in the multiphase reaction mixture; the second reactant forming gas bubbles and/or liquid droplets dispersed in the continuous phase; and reacting the first reactant with the second reactant in a process microchannel in the presence of at least one catalyst to form at least one product.
US08383869B2	Olefin oligomer composition An oligomer of alpha olefin is produced in a three step process comprising 1) oligomerization to a vinylidene, 2) hydroformylation to a primary alcohol, and 3) dimerization of the alcohol. The final product can be hydrogenated to form a branched alkane with improved lubricating oil properties.
US08383865B2	Curcumin derivatives The present invention is directed to a compound represented by Structural Formula (I): or a pharmaceutically acceptable salt thereof. The variables for Structural Formula (I) are defined herein. Also described is a pharmaceutical composition comprising the compound of Structural Formula (I) and its therapeutic use.
US08383864B2	Method for the conversion of cellulose and related carbohydrate materials to low-molecular-weight compounds Methods of converting cellulose or related biorenewable carbohydrate materials into high-value chemical compounds. The methods provide a means of converting low-cost materials such as cellulose and biomass into high yields of compounds such as ethylene glycol, propylene glycol, glycerin, methanol, hydroxyacetone, glycolaldehyde and dihydroxyacetone.
US08383859B2	Methods of preparing primary, secondary and tertiary carbinamine compounds in the presence of ammonia The present application relates to novel methods for the preparation of primary, secondary and tertiary carbinamine compounds, particularly the preparation of compounds of formulae I, IV and VI, from a carbonyl compound of formula II in the presence of ammonia or an ammonium equivalent of the formula NH4+X−, by way of allylation, crotylation, arylation, reductive amination and catalytic hydrogenation.
US08383853B2	Method for preparing 2,6-diethyl-4-methylphenylacetic acid The invention relates to novel 2,6-diethyl-4-methylphenyl-substituted tetramic acid derivatives of the formula (I) in which A, B, D and G are as defined above, to a plurality of processes and intermediates for their preparation and to their use as pesticides and/or herbicides, and also to selectively herbicidal compositions comprising, firstly, the 2,6-diethyl-4-methylphenyl-substituted tetramic acid derivatives of the formula (I) and, secondly, at least one crop plant tolerance promoter compound.
US08383852B2	Compounds having a cyclic moiety and compositions for delivering active agents Compounds comprising cyclic moiety and compositions for the delivery of active agents are provided. Methods of administration and preparation are provided as well.
US08383851B2	Lactylate synthesis methods using dilactides The present invention involves a new synthesis route for the formation of lactylates. The method comprises reacting a dilactide with a compound comprising a hydroxy group. This reaction is preferably carried out in the presence of a cation or other source of alkalinity. Preferred compounds comprising a hydroxy group include any fatty acid and fatty acid alcohol (particularly C1-C26 fatty acid chains). Preferred cations include cations of Group I and II metals, with sodium, calcium, and potassium cations being particularly preferred. The inventive reactions proceed much more rapidly than prior art lactylate synthesis reactions, and can be used to form 1-, 2-, 3-, 4-, and 5-lactylates.
US08383848B2	Transition metal compound and catalyst for olefin polymerization A transition metal compound represented by the formula (1-1) or the formula (1-2) (M is a transition metal atom) and a process for producing a catalyst for olefin polymerization comprising a step of bringing the transition metal compound into contact with a co-catalytic component for activation.
US08383846B2	Method of preparing alcohol esters from triglycerides and alcohols using heterogeneous catalysts combining at least a ZnxAl2O3+x type solid solution and ZnO A method of preparing a composition of alcohol esters of linear monocarboxylic acids with 6 to 26 carbon atoms from a vegetable or animal oil, neutral or acid, virgin or recycled, with monoalcohols having 1 to 18 carbon atoms, in the presence of a catalyst combining at least a solid solution of ZnxAl2O(3+x) type, wherein x ranges between 0 and 1 (end points excluded), and free ZnO present between 7 and 30 mass %, allows to directly obtain, in one or more stages, an ester that can be used as fuel and a pure glycerin.
US08383845B2	Extraction of highly unsaturated lipids with liquid dimethyl ether A process for obtaining lipids containing highly unsaturated fatty acids from plant or animal material, including contacting the material with liquid dimethyl ether to give a dimethyl ether solution containing lipids and a residue of plant or animal material, separating the solution from the residue of plant or animal material, and recovering lipids from the solution.
US08383842B2	Methods for purifying trans-(−)-Δ9-tetrahydrocannabinol and trans-(+)-Δ9-tetrahydrocannabinol Methods for making trans-(−)-Δ9-tetrahydrocannabinol and trans-(+)-Δ9-tetrahydrocannabinol are disclosed herein. In one embodiment, a trans-(−)-Δ9-tetrahydrocannabinol composition is prepared by allowing a composition comprising (±)-Δ9-tetrahydrocannabinol to separate on a chiral stationary phase to provide a trans-(−)-Δ9-tetrahydrocannabinol composition comprising at least about 99% by weight of trans-(−)-Δ9-tetrahydrocannabinol based on the total amount of trans-(−)-Δ9-tetrahydrocannabinol and trans-(+)-Δ9-tetrahydrocannabinol. The invention also relates to methods for treating or preventing a condition such as pain comprising administering to a patient in need thereof an effective amount of a trans-(−)-Δ9-tetrahydrocannabinol having a purity of at least about 98% based on the total weight of cannabinoids.
US08383839B2	Heterocyclidene acetamide derivative A compound represented by formula (I′): (wherein m, n, and p each represent 0 to 2; q represents 0 or 1; R1 represents halogen, a hydrocarbon group, a heterocyclic group, an alkoxy group, an alkoxycarbonyl group, a sulfamoyl group, a CN group, an NO2 group, or the like; R2 represents halogen, amino, a hydrocarbon group, an aromatic heterocyclic group, or an oxo group; X1 represents O, —NR3—, or —S(O)r-; X2 represents a methylene group, O, —NR3—, or —S(O)r-; Q′ represents a heteroaryl group, a heteroarylalkyl group, a substituted aryl group, or an aralkyl group; Cycle moiety represents an aryl ring or a heteroaryl ring; and the wavy line represents an E-isomer or a Z-isomer), a salt of the compound, or a solvate of the compound or the salt. A pharmaceutical composition and a transient receptor potential type I (TRPV1) receptor antagonist each contain, as an active ingredient, at least one of the compound, a salt of the compound, and a solvate of the compound or the salt.
US08383829B2	Electrochromic compound, electrode, and display element An electrochromic compound represented by Formula (1), wherein R1 is an alkyl group, an alkenyl group, an aryl group, or a heterocyclic group; R2 and R3 are each a hydrogen atom or a substituent; X is N—R4, an oxygen atom, or a sulfur atom; and R4 is a hydrogen atom or a substituent; provided that at least one of R1-R4 has a partial structure represented by Formula (2), —Si(Y)nR′(3-n) Formula (2) wherein Y is a halogen atom or OR, R is an alkyl group, or an aryl group; R′ is an alkyl group, an alkenyl group, an aryl group, or a heterocyclic group, and n is an integer of 1-3.
US08383826B2	Derivatives of 1-phenyl-2-pyridinyl alkyl alcohols as phosphodiesterase inhibitors Derivatives of 1-phenyl-2-pyridinyl alkyl alcohols are useful as inhibitors of the phosphodiesterase 4 (PDE4) enzyme.
US08383824B2	Heterocyclic antiviral compounds Compounds having the formula I wherein wherein R1, R2 and R3 are as defined herein are Hepatitis C virus NS5b polymerase inhibitors with improved bioavailability. Also disclosed are compositions and methods for treating an HCV infection and inhibiting HCV replication.
US08383819B2	Method for producing 4-oxoquinoline compound The present invention provides a compound useful as a synthetic intermediate for an anti-HIV agent having an integrase inhibitory activity, and a production method thereof, and a production method of an anti-HIV agent using the synthetic intermediate. Specifically, for example, a compound represented by the formula (2′): wherein R is a fluorine atom or a methoxy group, and R400 is a hydrogen atom or a C1-C4 alkyl group, or a salt thereof, and a production method thereof, and a production method of an anti-HIV agent using the synthetic intermediate.
US08383806B2	Method of reversing carboplatin resistance by inhibition of HGFIN The present invention discloses the cloning of a new cDNA, HGFIN, from stimulated bone marrow stromal cells that was retrieved with a probe specific for the neurokinin-1 (NK-1) receptor. The novel gene, HGFIN, encodes a protein receptor that is involved in the regulation of hematopoietic proliferation and differentiation. HGFIN is implicated in the treatment of hyperproliferative disorders, particularly bone and breast cancer, because it acts to suppress the proliferating cells.
US08383802B2	Nucleic acids encoding antibodies that bind factor D The invention relates to factor D inhibitors, which bind to factor D and block the functional activity of factor D in complement activation. The inhibitors include antibody molecules, as well as homologues, analogues and modified or derived forms thereof, including immunoglobulin fragments like Fab, F(ab′)2 and Fv, small molecules, including peptides, oligonucleotides, peptidomimetics and organic compounds. A monoclonal antibody which bound to factor D and blocked its ability to activate complement was generated and designated 166-32. The hybridoma producing this antibody was deposited at the American Type Culture Collection, 10801 University Blvd., Manassas, Va. 20110-2209, under Accession Number HB-12476.
US08383801B2	Polynucleotide encoding a sclerostin-binding antibody Compositions and methods relating to epitopes of sclerostin protein, and sclerostin binding agents, such as antibodies capable of binding to sclerostin, are provided.
US08383797B2	Luciferase gene optimized for use in imaging of intracellular luminescence The present invention provides a gene construct encoding pH insensitive luciferase for visualizing intracellular information, wherein an intracellular expression activity is higher compared with a gene construct of luciferase derived from a firefly.
US08383791B1	Oligonucleotides A single stranded oligonucleotide having substantially no secondary structure and formed of nucleotide residues wherein two or more internal nucleotide residues are labelled with a fluorophore without an associated quencher. Typically at least two of the nucleotide residues labelled with a fluorophore are separated by at least two unlabelled nucleotide residues. The oligonucleotides are useful in the investigation of target polynucleotide sequences.
US08383790B2	Modified surface antigen Novel proteins that constitute modified forms of a Neisseria meningitidis surface antigen and encoding nucleic acids are provided. The modified surface proteins are characterized by having deletions of non-conserved amino acids, and thereby being capable of eliciting cross-protective immune responses against Neisseria meningitidis. The invention extends to the use of the modified surface antigens in diagnostics, in therapeutic and prophylactic vaccines and in the design and/or screening of medicaments. The modified surface antigens are particularly useful in vaccines which effectively immunize against a broader spectrum of N. meningitidis strains than would be expected from a corresponding wild-type surface antigen.
US08383788B2	C-Fos induced growth factor (FIGF) and DNA encoding same A nucleotide molecule encoding a protein encoded by a Fos regulated gene or a fragment thereof, wherein said protein or fragment thereof is encoded by any one of the nucleotide sequences shown in FIG. 1 or 2 or a fragment thereof, including allelic variants and species variants of the nucleotide sequences.
US08383785B2	Anti-bacterial activity of 9-hydroxy derivatives of 6,11-bicyclolides The present invention discloses compounds of formula (I) or pharmaceutically acceptable salts, esters, or prodrugs thereof: which exhibit superior antibacterial properties, particularly against Haemophilus influenzae. The present invention further relates to pharmaceutical compositions comprising the aforementioned compounds for administration to a subject in need of antibiotic treatment. The invention also relates to methods of treating a bacterial infection in a subject by administering a pharmaceutical composition comprising the compounds of the present invention. The invention further includes process by which to make the compounds of the present invention.
US08383784B2	Lignothermoplastic A thermoplastic material made from lignin, polyol and a melting point reducer where the melting point reducer is miscible in the specific polyol employed and where the lignin, polyol and melting point reducer are all miscible when in their melted state.
US08383783B2	Simple method for simultaneous removal of multiple impurities from culture supernatants to ultralow levels This invention is directed to methods for removing, preferably simultaneously and in one step, multiple impurities form crude culture samples, and, in particular, the removal of media components, protein, nucleic acids, lipids, and lipopolysaccharides to ultralow levels. Preferably the purification process comprises: (1) binding of the target substance containing one or more contaminants to a chromatography matrix; (2) washing the bound target substance with one or more buffers containing a synergistic combination of a lyotropic agent or organic solvent, a detergent, and a salt component; and (3) desorbing the target substance from the chromatography matrix, so that the eluate contains ultra low levels of contaminants. The reduction of impurities that can be achieved is preferably 91-99.9% as compared to the amount of impurities in the target substance before purification. The invention is also directed to the targets products that have been so purified.
US08383779B2	Human antibodies that bind mesothelin, and uses thereof The present disclosure provides isolated monoclonal antibodies that specifically bind to mesothelin with high affinity, particularly human monoclonal antibodies. Preferably, the antibodies bind human mesothelin. In certain embodiments, the antibodies are capable of internalizing into mesothelin-expressing cells or are capable of mediating antigen dependent cellular cytotoxicity. The invention further provides anti-mesothelin antibodies that can inhibit the binding of mesothelin to the ovarian cancer antigen CA125. Nucleic acid molecules encoding the antibodies of this disclosure, expression vectors, host cells and methods for expressing the antibodies of this disclosure are also provided. Antibody-partner molecule conjugates, bispecific molecules and pharmaceutical compositions comprising the antibodies of this disclosure are also provided. This disclosure also provides methods for detecting mesothelin, as well as methods for treating cancers, such as mesotheliomas, pancreatic cancers and ovarian cancers, using an anti-mesothelin antibody of this disclosure.
US08383778B2	IL-1 binding proteins The present invention encompasses IL-1α binding proteins. Specifically, the invention relates to antibodies that are chimeric, CDR grafted and humanized antibodies. Antibodies of the invention have high affinity for IL-1α and neutralize IL-1α activity. An antibody of the invention can be a full-length antibody or an antigen-binding portion thereof. Method of making and method of using the antibodies of the invention are also provided. The antibodies, or antibody portions, of the invention are useful for detecting IL-1α and for inhibiting IL-1α activity, e.g., in a human subject suffering from a disorder in which IL-1α activity is detrimental.
US08383776B2	Purification of factor XIII polypeptides from biological materials The invention relates to a method for purifying a factor XIII polypeptide from a biological material, the method comprising subjecting the material to sequential chromatography on an anion-exchange matrix and a hydrophobic interaction matrix.
US08383771B2	Altered peptide ligand derived from HSP60 and pharmaceutical compositions Peptides of human heat shock protein of 60 kDa, that constitute epitopes for T cells, as well as their derived peptides, which are modified at the contact sites with the MHC molecule, are useful to induce mechanisms of peripheral tolerance, in particular mechanisms of anergy or mediated by clones of regulatory T cells in patients with Rheumatoid Arthritis. The invention also refers pharmaceutical compositions comprising such peptides for the treatment of Rheumatoid Arthritis.
US08383769B2	Peptides for inhibiting chemokine binding to chemokine receptors Novel peptidic or peptidomimetic agents or small molecules for modulating the biological effect of a chemokine. According to the present invention, the therapeutic agents preferably are endowed with the capacity to bind to certain chemokines in order to modulate the biological interaction between the target ligand, chemokine, and the respective target receptor, chemokine receptor. These peptides may be described as agonist ligands or antagonists. Next, preferably certain peptides share consensus sequences are described which characterize the families or categories of these modulator peptides.
US08383765B2	Polyester for toner A polyester for a toner, obtainable by polycondensing an alcohol component and a carboxylic acid component containing a fumaric acid-modified rosin; and a toner containing the polyester for a toner. The polyester for a toner of the present invention is usable as a resin binder for a toner usable in, for example, developing electrostatic latent images formed in electrophotography, electrostatic recording method, electrostatic printing method or the like.
US08383757B2	Device and method for degassing solvent-containing polycarbonate solutions The invention relates to an apparatus and a process for devolatilizing solvent-containing polycarbonate solutions. By employing the inventive apparatus, polycarbonates with low residual values of volatile constituents are produced from solvent-containing polymer melts, which improved optical properties, especially yellowness index, with the aid of an apparatus combination of a heatable tubular devolatilizer and a vented extruder.
US08383756B2	High density data storage medium, method and device A composition of matter for the recording medium of nanometer scale thermo-mechanical information storage devices and a nanometer scale thermo-mechanical information storage device. The composition includes: one or more polyaryletherketone copolymers, each of the one or more polyaryletherketone copolymers comprising (a) a first monomer including an aryl ether ketone and (b) a second monomer including an aryl ether ketone and a first phenylethynyl moiety, each of the one or more polyaryletherketone copolymers having two terminal ends, each terminal end having a phenylethynyl moiety the same as or different from the first phenylethynyl moiety. The one or more polyaryletherketone copolymers are thermally cured and the resulting cross-linked polyaryletherketone resin used as the recording layer in an atomic force data storage device.
US08383750B2	Amphiphilic co-polymer conjugates for a controlled release of active molecules The present invention relates to the field of perfumery. More particularly, it concerns polyethylene or polypropylene based polymers that have at least one β-oxy or β-thio carbonyl moiety capable of liberating a perfuming molecule such as, for example, an α,β-unsaturated ketone, aldehyde or carboxylic ester. The present invention concerns also the use of such compounds in perfumery as well as the perfuming compositions or perfumed articles that include such compounds.
US08383748B2	Cast acrylic plates with enhanced shockproofness Process for the preparation of impact-strengthened cast PMMA sheets comprising the following stages: 1. a mixture comprising: at least one alkoxyamine Z(-T)n, in which Z denotes a polyvalent group and n an integer greater than 2, preferably of between 2 and 10, advantageously between 2 and 8, and the monomer(s) intended to form a central block B is heated to a temperature sufficient to activate the alkoxyamine and polymerize the monomer(s); 2. the central block B, optionally mixed with the unconsumed monomer(s) from stage 1, is reactivated in the presence of the monomer(s) intended to form the branches A; 3. MAM and optionally at least one comonomer M which can be copolymerized by the radical route with MMA and at least one radical initiator are added to the mixture obtained in stage 2; 4. the mixture from stage 3 is cast in a mould and then heated.
US08383737B2	Compound for gap-filling of semiconductor device and coating composition using the same A compound for filling small gaps in a semiconductor device and a composition comprising the compound are provided. The composition can completely fill holes having a diameter of 70 nm or less and an aspect ratio (i.e. height/diameter ratio) of 1 or more in a semiconductor substrate without any defects, e.g., air voids, by a general spin coating technique. In addition, the composition can be completely removed from holes at a controllable rate without leaving any residue by the treatment with a hydrofluoric acid solution after being cured by baking. Furthermore, the composition is highly stable during storage.
US08383735B2	Sulfonated block copolymers, method for making same, and various uses for such block copolymers A pre-cursor block copolymer for sulfonation which, prior to hydrogenation, has the general configuration A-B-A, A-B-A-B-A, (A-B-A)nX, (A-B)nX, A-D-B-D-A, A-B-D-B-A, (A-D-B)nX, (A-B-D)nX or mixtures thereof, wherein A, B and D blocks do not contain any significant levels of olefinic unsaturation. Each A and D block is a polymer block resistant to sulfonation, and each B block is a polymer block susceptible to sulfonation. Each A block is a segment of one or more polymerized para-substituted styrene monomers, each B block contains segments of one or more vinyl aromatic monomers selected from polymerized (i) unsubstituted styrene monomers, (ii) ortho-substituted styrene monomers, (iii) meta-substituted styrene monomers, (iv) alpha-methylstyrene, (v) 1,1-diphenylethylene, (vi) 1,2-diphenylethylene and (vii) mixtures thereof, and each D block contains polymers having a glass transition temperature less than 20° C. and a number average molecular weight of between 1,000 and 50,000.
US08383733B2	Low-viscosity polymer polyols characterized by a high hydroxyl number The present invention relates to novel polymer polyols which have low viscosities and high hydroxyl numbers, and to a process for the preparation of these novel polymer polyols. These polymer polyols have hydroxyl numbers of ≧20, solids contents of about 30 to about 65% by weight and a viscosity that is less than or equal to: be[2.7c]. These comprise the reaction product of a base polyol, a preformed stabilizer and at least one ethylenically unsaturated monomer, in the presence of a free-radical polymerization initiator and at least one polymer control agent. The base polyol has a hydroxyl number of 60 to 1900, a functionality of 1 to 10, and an equivalent weight of 30 to 900.
US08383732B1	Static resistant synthetic construction material A static resistant synthetic inter-connectable structural formulation which can support vehicles, heavy equipment, drilling rigs while providing static charge dissipation, resistance to corrosive materials consisting of polyethylene; polyethylene terephthalate, styrene-butadiene rubber; an antistatic material that partially protrudes through a formed outer surface of the formulation; and an ultraviolet stabilizer material.
US08383731B2	Polypropylene-based adhesive compositions An adhesive blend is described that can include a semi-crystalline copolymer of propylene and at least one comonomer selected from the group consisting of ethylene and at least one C4 to C20 α-olefin, the copolymer having a weight average molecular weight (Mw) from about 15,000 to about 200,000; an melt index (MI) from about 7 dg/min to about 3000 dg/min as measured by ASTM D 1238 (B), and a (Mw/Mn) of approximately 2. Various production processes are also described. Also described are adhesive compositions and methods for making adhesive compositions having polymers or polymer blends with melt flow rates (MFRS) equal to and above 250 dg/min. at 230°C. Certain specific embodiments of the invention involve the use of a free radical initiator, e.g., a peroxide.
US08383729B2	Rubber filled oriented polymer composition article Including crosslinked rubber particles in an oriented polymer composition induces cavitation in the oriented polymer composition and can increases the scratch and mar resistance as well as fibrillation resistance.
US08383724B2	Aqueous coating composition based on a binder mixture as base coat The invention relates to an aqueous coating composition based on a combination of aqueous binders and crosslinker, to a process for preparing it and to use for single-coat or multi-coat paint systems, especially coatings having anti-stonechip properties.
US08383718B2	Pigmented strip paint Aqueous strippable paint comprising one or more pigments, a polyether polyurethane binder having anionic stabilizing groups, and a second polyether having at least 20 wt. % of lipophilic parts. The first polyether has an acid number of at least 8, preferably at least 12, and the second polyether has 30-70 wt % of lipophilic parts. The mixing ratio of the first and second polyethers is at least 20:1. The second polyether comprises a lipophilic polyester and/or polyurethane backbone. The polyether polyurethane binder has a Tg of less than −42° C.
US08383713B2	Hydrolytically stable polyurethane nanocomposites The water-resistance properties of polyester-based polyurethanes are remarkably enhanced, without adversely affecting the transparency properties of these materials to any significant degree, by including in the polymer a substantially dispersed nano-particle proton scavenger.The hydrolytic stability and water-resistance properties of polyester-based polyurethanes are remarkably enhanced and match those of polycarbonate-based polyurethanes, without adversely affecting the transparency of these materials to any significant degree, by including in the polymer a substantially dispersed nano-particle proton scavenger such as calcium carbonate.
US08383711B2	Rubber composition for tire The present invention relates to a rubber composition for a sidewall, a clinch and an insulation comprising 20 to 60 parts by mass of filler, 1.0 to 4.0 parts by mass of sulfur and 0.1 to 10 parts by mass of at least one vulcanization accelerating aid selected from a group comprising a citraconimide compound, an organic thiosulfate compound, an alkylphenol-sulfur chloride condensate, a compound represented by the formula (2) and a metal salt of methacrylic acid represented by the formula (3), based on 100 parts by mass of a diene rubber component comprising 10 to 70% by mass of at least one diene rubber component (a) selected from a group comprising a solution polymerization-modified styrene-butadiene rubber, a tin-modified butadiene rubber and a butadiene rubber whose terminal is modified with a compound represented by the formula (1), and 20 to 80% by mass of a diene rubber component (b) other than the diene rubber component (a) for the purpose of improving rolling resistance and steering stability.
US08383706B2	Benzoxazine-thiol adducts Novel benzoxazine-thiol adducts are described, which may be may be cured to produce compositions useful in coating, sealants, adhesive and many other applications.
US08383702B2	Composite materials having improved thermal performance A composite material includes a non-polar polymer and alumina hydrate particulate. The composite material has a Heat Distortion Performance of at least about 10% relative to the non-polar polymer absent the alumina hydrate particulate. The composite material may include a coupling agent including a phosphinic acid group, a phosphonic acid group or an ester derivative thereof.
US08383700B2	Pigment dispersion, recording ink, ink cartridge, ink-jet recording method and ink-jet recording apparatus A recording ink containing a pigment dispersion, a surfactant, a water-dispersible resin, a humectant and water. The pigment dispersion contains a pigment dispersant, which is an anionic surfactant or a nonionic surfactant having an HLB value of 10 to 20. The pigment dispersion also contains a polymer dispersion stabilizer, which is an alpha-olefin/maleic anhydride copolymer expressed by the formula (1) below, where R is an alkyl group having 6 to 25 carbon atoms, and where the mass average molecular weight of the copolymer is 5000 to 20000. An ink cartridge, an inkjet recording method, an inkjet recording apparatus, and an ink recorded matter, each employing the recording ink, are also provided.
US08383698B2	Esters of cyclohexane polycarboxylic acids as plasticizers in rubber compounds It has been discovered that the use of a plasticizer, an ester of a cyclohexanepolycarboxylic acid, especially a 1,2-cyclohexanedicarboxylic acid ester, that is environmentally non-toxic, can replace environmentally unfriendly phthalate plasticizers, such as dioctyl phthalates used in vulcanizable rubber compositions, especially for tires, on a one to one weight basis (phr) without sacrificing beneficial rubber properties.
US08383696B2	Water-absorbing resin composition A water-absorbent resin composition having an antimicrobial property, which suppresses the generation of dust of the antimicrobial agent. A water-absorbent resin composition comprising a water-absorbent resin and an antimicrobial agent comprising an inorganic compound carrying an antimicrobial metal, the water-absorbent resin composition being characterized in that the degree of generated dust of the water-absorbent resin composition is at most 100 CPM. The water-absorbent resin composition of the present invention can be suitably used as hygienic materials such as disposable diaper, sanitary napkin and incontinence pad; urine-absorbent materials for pets; materials for civil engineering and construction such as packing materials; drip absorbents; food freshness retaining materials such as cold-reserving agents; horticultural articles such as water-retaining materials for soils; and the like.
US08383695B2	Phenoxy resin for optical material, resin composition for optical material, resin film for optical material and optical waveguide using those The present invention relates to a phenoxy resin for an optical material obtained by subjecting at least one selected from specific difunctional epoxy resins and at least one selected from specific difunctional phenols to polyaddition reaction, wherein a film comprising the above phenoxy resin has a refractive index of 1.580 or less at 25° C. and a wavelength of 830 nm, a resin composition for an optical material containing the above phenoxy resin, a resin film for an optical material comprising the above resin composition and an optical waveguide produced by using the above resin composition and/or the above resin film. The present invention can provide a phenoxy resin for an optical material which is excellent in a heat resistance and a transparency and which has a low refractive index, a resin composition for an optical material containing the above phenoxy resin, a resin film for an optical material comprising the above resin composition and an optical waveguide produced by using the above resin composition and/or the above resin film.
US08383692B2	Method of activating boron nitride A method of activating boron nitride comprises exposing the boron nitride to a fluid enabling —OH hydroxyl radicals and/or H3O+ to be delivered and creating B—OH bonds and/or NH2 bonds in the boron nitride, and eliminating the fluid and recovering the activated boron nitride.
US08383690B2	Pharmaceutical composition useful for the treatment of peptic ulcer diseases The present invention deals with the pharmaceutical composition comprising the therapeutically effective amount of a compound oenothein C obtained from the bioactive fraction of plant Woodfordia fruticosa optionally along with one or more pharmaceutically acceptable carriers, additives, lubricants and diluents. Further it also provides a method of treating peptic ulcer diseases in a subject using the said pharmaceutical composition. It also relates to the use of the compound oenothein C in the treatment of peptic ulcer related diseases and a process for the isolation of the said compound.
US08383689B2	Skin cosmetics comprising cocoon-shaped polymer fine particles The present skin cosmetics comprising cocoon-shaped polymer fine particles having an average particle size of 1 to 8 μm and cosmetic vehicles show an effect of making fine wrinkles on the skin unnoticeable, letting the skin appear smoother and fairer.
US08383688B2	Products with water clusters A product has solid stable water clusters including a plurality of water molecules connected with one another by electrical dipole interaction via internal electric field of ions and having a permanent electric dipole moment with an electrical field surrounding the solid stable water clusters.
US08383684B2	Methods and formulations for treating ineffective or decreased esophagal motility Disclosed embodiments describe pharmaceutical compositions and methods for treating ineffective esophageal motility in which bethanechol and pharmaceutically acceptable absorption enhancers including bile acids and mixtures thereof are topically introduced to the esophagus. Therapeutically effective amounts of bethanechol are delivered while reducing or eliminating parasympathetic nervous system side effects normally associated with systemic bethanechol delivery.
US08383682B2	Mixed ligand surface-modified nanoparticles A composition comprises surface-modified nanoparticles of at least one amphoteric metal oxide or oxyhydroxide. The nanoparticles bear, on at least a portion of their surfaces, a surface modification comprising (i) at least one surface modifier selected from lactate, thiolactate, and mixtures thereof, and (ii) at least one surface modifier selected from halide, nitrate, acetate, carbonate, formate, propionate, sulfate, bromate, perchlorate, tribromoacetate, trichloroacetate, trifluoroacetate, carboxylate comprising from one to about four alkyleneoxy moieties, chlorate, and mixtures thereof.
US08383680B2	Composition comprising free amino acids A method is provided for the prevention and treatment of patients having impaired gastro-intestinal tract function. The method comprises the steps of administering to a patient requiring same free amino acids including about 9.0% to about 17.0% glutamic acid.
US08383679B2	Crystal form of calcium 3-acetylaminopropane-1-sulfonate The present invention relates to a novel crystal form of calcium 3-acetylaminopropane-1-sulfonate, to a process for the preparation thereof, and to the use thereof in medicaments.
US08383677B2	Nerve-regenerating agent A nerve-regenerating agent comprising, as an active ingredient, arachidonic acid and/or a compound containing arachidonic acid as a constituent fatty acid.
US08383675B2	Natural marine source phospholipids comprising polyunsaturated fatty acids and their applications A phospholipid extract from a marine or aquatic biomass possesses therapeutic properties. The phospholipid extract comprises a variety of phospholipids, fatty acid, metals and a novel flavonoid.
US08383673B2	Nitridoosmium(VI) complexes for treatment of cancer The invention relates to nitridoosmium complexes and methods of using these compounds as treatments for cancer.
US08383670B2	Trisubstituted thiophenes that modulate intracellular calcium Described herein are compounds of Formula (I): wherein A, J, Z, X, R1, and R4 are defined herein, and pharmaceutical compositions containing such compounds, which modulate the activity of store-operated calcium (SOC) channels. Also described herein are methods of using such SOC channel modulators, alone and in combination with other compounds, for treating diseases or conditions that would benefit from inhibition of SOC channel activity.
US08383667B2	Forms of [R-(R,R)]-2-(4-fluorophenyl)-β,δ-dihydroxy-5-(1-methylethyl)-3-phenyl-4-[(phenylamino)carbonyl]-1H-pyrrole-1-heptanoic acid magnesium Novel forms of atorvastatin magnesium salt designated Form A, Form B, Form C, Form D, Form E, and Form F, pharmaceutical compositions containing such compounds, methods for their preparation and methods utilizing the compounds for treatment of hyperlipidemia, hypercholesterolemia, osteoporosis, benign prostatic hyperplasia (BPH) and Alzheimer's disease are described.
US08383664B2	Crystalline modification of fipronil The present invention relates to a crystalline modification of fipronil, to a process for the preparation of the same, to pesticidal and parasiticidal mixtures and compositions comprising said crystalline modification and to their use for combating pests and parasites.
US08383661B2	1,3 imidazolidine derivatives and their use in the production of carbapenem Preparation of new heterocyclic compounds characterized by 1,3-imidazolidine structure useful for stereoselective synthesis of optically pure key intermediates in 1β-methylcarbapenem production.
US08383657B2	Thiazolylidine urea and amide derivatives and methods of use thereof The invention relates to novel thiazolylidine urea and amide derivatives that are PAMs of neuronal nicotinic receptors, compositions comprising the same, processes for preparing such compounds, and methods for using such compounds and compositions.
US08383652B2	Biaromatic compounds that modulate PPAR-receptors Novel biaromatic compounds that modulate peroxisome proliferator-activator receptors, known as PPAR, having the formula (I): are formulated into pharmaceutical compositions useful in human or veterinary medicine, or alternatively, in cosmetic compositions.
US08383650B2	Organic compounds The present invention relates to a compound of the formula I wherein R1, R2, R3, R4 and R5 are as defined in the specification, for use in the diagnostic and therapeutic treatment of a warm-blooded animal, especially for the treatment of a disease (=disorder) that depends on activity of renin; the use of a compound of that class for the preparation of a pharmaceutical formulation for the treatment of a disease that depends on activity of renin; the use of a compound of that class in the treatment of a disease that depends on activity of renin; pharmaceutical formulations a compound of that class; a method of treatment comprising administering a compound of that class and a method for its manufacture.
US08383649B2	Crystalline forms of naltrexone methobromide The present invention relates to novel crystalline forms of naltrexone methobromide including hydrated and solvated forms. The invention also describes methods of preparing the various crystalline forms. The present invention also relates to pharmaceutical compositions containing crystalline forms of naltrexone methobromide, as well as methods of treating or preventing opioid induced side effects by administering the pharmaceutical compositions.
US08383647B2	Quinoline derivative The present invention provides a compound having a melanin-concentrating hormone receptor antagonistic action and low toxicity, which is useful as an agent for the prophylaxis or treatment of obesity and the like.The present invention relates to a compound represented by the formula (I): wherein each symbol is as defined in the specification, or a salt thereof.
US08383645B2	Stable laquinimod preparations The invention relates to a pharmaceutical composition comprising a pharmaceutically acceptable salt of N-ethyl-N-phenyl-1,2,-dihydro-4-hydroxy-5-chloro-1-methyl-2-oxoquinoline-3-carboxamide, N-methylglucamine, and a pharmaceutically acceptable carrier.
US08383642B2	Spiropiperidine compounds A compound of the formula: or a pharmaceutically acceptable salt thereof as well as a pharmaceutical composition, and a method for treating diabetes.
US08383636B2	Acyclic amine inhibitors of 5-methytioadenosine phosphorylase and nucleosidase The present invention relates to compounds of the general formula (I) which are inhibitors of 5′-methylthioadenosine phosphorylase or 5′-methylthioadenosine nucleosidase. The invention also relates to the use of these compounds in the treatment of diseases or conditions in which it is desirable to inhibit 5′-methylthioadenosine phosphorylase or 5′-methylthioadenosine nucleosidase including cancer, and to pharmaceutical compositions containing the compounds.
US08383634B2	Methods of treatment using heteroaryl compounds and compositions thereof Provided herein are Heteroaryl Compounds having the following structure: wherein R1, R3, R4, L, X, Y, A and B are as defined herein, compositions comprising an effective amount of a Heteroaryl Compound and methods for treating or preventing cancer, inflammatory conditions, immunological conditions, metabolic conditions and conditions treatable or preventable by inhibition of a kinase pathway comprising administering an effective amount of a Heteroaryl Compound to a patient in need thereof.
US08383626B2	Nitric oxide donors for inducing neurogenesis There is provided a method of promoting neurogenesis by administering a therapeutic amount of a nitric oxide donor compound to a patient in need of neurogenesis promotion. Also provided is a compound for providing neurogenesis having an effective amount of a nitric oxide donor sufficient to promote neurogenesis. A nitric oxide compound for promoting neurogenesis is also provided. Further, a method of augmenting the production of brain cells and facilitating cellular structural and receptor changes by administering an effective amount of a nitric oxide donor compound to a site in need of augmentation is provided. There is provided a method of increasing both neurological and cognitive function by administering an effective amount of a nitric oxide donor compound to a patient.
US08383625B2	Pyrrolidinium derivatives as M3 muscarnic receptor antagonists Compounds of formula (I) in salt or zwitterionic form, wherein R1, R2, R3, R4 and R5 have the meanings as indicated in the specification, are useful for treating conditions that are mediated by the muscarinic M3 receptor. Pharmaceutical compositions that contain the compounds and a process for preparing the compounds are also described.
US08383624B2	Pyrrolopyrazine inhibitors of kinases The present invention relates to compounds of formula (I) or pharmaceutical acceptable salts, wherein R1a, R1b, X, and Y are defined in the description. The present invention relates also to compositions containing said compounds which are useful for inhibiting kinases such as Cdc7 and methods of treating diseases such as cancer.
US08383623B2	Phthalazin-(2H)-one inhibitors of kinases The present invention relates to compounds of formula (I) or pharmaceutical acceptable salts, wherein R1a, R1b, R1c, X, Y, Z, n, and m are defined in the description. The present invention relates also to compositions containing said compounds which are useful for inhibiting kinases such as Cdc7 and methods of treating diseases such as cancer.
US08383622B2	Nitrogen-containing heterocyclic derivative having 11β-hydroxysteroid dehydrogenase type I inhibitory activity Disclosed is a compound which is useful as an 11β-hydroxysteroid dehydrogenase type 1 inhibitor.A compound represented by the formula: its pharmaceutically acceptable salt, or a solvate thereof, wherein Ring A is a group represented by the formula: Ring B is optionally substituted heteroaryl, provided that optionally substituted isoxazole is excluded, or optionally substituted heterocycle, R1 is hydrogen or optionally substituted alkyl, R2 is —OR5, —SR5, halogen, halogenated alkyl or the like, R3 is optionally substituted alkyl or the like, R4 is optionally substituted alkyl or the like, R5 is optionally substituted alkyl or the like, R6 is hydrogen or the like, R7 and R8 are each independently hydrogen or the like, R10 and R11 are each independently hydrogen or the like, R12 is optionally substituted alkyl or the like, m and p are each independently integer of 1 to 3.
US08383620B2	Phosphoinositide 3-kinase inhibitor compounds and methods of use Compounds of Formulas Ia-d where X is S or O, mor is a morpholine group, and R3 is a monocyclic heteroaryl group, and including stereoisomers, geometric isomers, tautomers, solvates, metabolites and pharmaceutically acceptable salts thereof, are useful for modulating the activity of lipid kinases including PI3K, and for treating disorders such as cancer mediated by lipid kinases. Methods of using compounds of Formula Ia-d for in vitro, in situ, and in vivo diagnosis, prevention or treatment of such disorders in mammalian cells, or associated pathological conditions, are disclosed.
US08383619B2	Pharmaceutical compounds The invention provides a compound of the formula (1): or a salt, solvate, N-oxide or tautomer thereof; wherein either R1 is R1a and R2 is R2a; or R1 is R1b and R2 is R2b; provided that in each case at least one of R1 and R2 is other than hydrogen; R1a and R2a are the same or different and each is selected from hydrogen, C1-4 alkyl, C2-4 alkenyl and C2-4 alkynyl wherein the C1-4 alkyl is optionally substituted by C1-2 alkoxy; R1b and R2b are the same or different and are selected from hydrogen, C(O)NR4R5, C(O)R6 and C(O)OR6 where R6 is C1-4 alkyl, R4 and R5 are both C1-4 alkyl, or NR4R5 forms a 4 to 7 membered saturated heterocyclic ring optionally containing a second heteroatom ring member selected from O, N or S and oxidized forms of N and S, the heterocyclic ring being optionally substituted by one or two C1-4 alkyl groups and/or one or two oxo groups; and R3 is a group D: wherein the asterisk denotes the point of attachment to the isoindoline ring; but excluding acetic acid 5-acetoxy-4-isopropyl-2-[5-(4-methyl-piperazin-1-ylmethyl)-1,3-dihydro-isoindole-2-carbonyl]-phenyl ester.
US08383617B2	Treatment of protein aggregation diseases A method of treatment for the prevention or therapy of a protein aggregation disease includes the administration in combination of a first active medicament and a second active medicament, wherein the first active medicament is active to impede aggregation of amyloid protein and the second active medicament is active to disaggregate previously formed aggregates of amyloid protein.
US08383616B2	Aryl isoxazole compounds with antitumoural activities The present invention relates to formula I compounds having antitumoural activities through, as one possible biological target, the molecular chaperone heat shock protein 90 (Hsp90) inhibition. The invention includes the use of such compounds in medicine, in relation to cancer disease as well as other diseases where an inhibition of Hsp90 is responsive, and the pharmaceutical compositions containing such compounds.
US08383615B2	Azetidine 2-carboxamide derivatives which modulate the CB2 receptor Compounds of the formula (I), (II) and (III) which modulate the CB2 receptor are disclosed. Compounds according to the invention bind to and are agonists of the CB2 receptor, and are useful for treating inflammation. Those compounds which are agonists are additionally useful for treating pain.
US08383613B2	Methods for the treatment of cancer Compositions and methods for the treatment of malignancy and chronic viral infection are disclosed.
US08383609B2	Phosphorus containing heterocyclic compounds, sugar analogues, and compositions having anti-cancer activity containing the same A new anticancer compounds of formula (1) Drugs and pharmaceutical compositions to be used in human or veterinary medicine, which include at least one compound of formula (1). A method of treating and/or preventing cancer in a human or an animal using the compound of formula (1)
US08383607B2	Perifosine and capecitabine as a combined treatment for cancer Treatment regimens comprising co-treatment of cancer with perifosine and capecitabine are disclosed herein, as well as pharmaceutical compositions and unit dosage forms thereof formulated to be suitable for use in said treatment regimens.
US08383606B2	Sulfoalkyl ether cyclodextrin compositions SAE-CD compositions are provided, along with methods of making and using the same. The SAE-CD compositions comprise a sulfoalkyl ether cyclodextrin having an absorption of less than 0.5 A.U. due to a drug-degrading agent, as determined by UV/vis spectrophotometry at a wavelength of 245 nm to 270 nm for an aqueous solution containing 300 mg of the SAE-CD composition per mL of solution in a cell having a 1 cm path length.
US08383603B2	Means and methods for counteracting, delaying and/or preventing heart disease The invention relates to the fields of molecular biology and medicine, more specifically to treatment and prevention of heart disease. The invention provides alternative methods for counteracting, diminishing, treating, delaying and/or preventing heart disease.
US08383595B2	Peptide derivative and composition for promoting tear secretion comprising the same A composition for promoting lacrimal secretion which can be used safely and effectively in the lacrimal secretion promoting therapy, not in the conventional supplemental therapy of lacrimal fluid components is provided. The composition for promoting lacrimal secretion comprising a peptide derivative represented by the formula (I): and a contact lens which retains and/or contains the composition are provided.
US08383592B2	Apo A-I mimetic peptides and methods of treatment A method including advancing a delivery device through a lumen of a blood vessel to a particular region in the blood vessel; and introducing a synthetic apolipoprotein A-1 (Apo A-I) mimetic peptide into a wall of the blood vessel at the particular region, wherein the peptide has a property that renders the peptide effective in reverse cholesterol transport. A composition including a synthetic apolipoprotein A-I (Apo A-I) mimetic peptide, or combination of an Apo A-I synthetic peptide and an Acyl CoA cholesterol: acyltransferase (ACAT) inhibitor in a form suitable for delivery into a blood vessel, the peptide including an amino acid sequence in an order reverse to an order of an endogenous Apo A-I related peptide. A composition including an apolipoprotein A-1 (Apo A-I) synthetic peptide in a form suitable for delivery into a blood vessel, the peptide including an amino acid backbone that has less amino acid residues relative to endogenous Apo A-I and a chimera of helix 1 and helix 9 of Apo A-I.
US08383591B2	Peptides for treating cancer The present invention relates to peptide from 4 to 50 amino acids comprising a phosphorylated pYX1X2X1 motif (SEQ ID NO: 1), wherein each X1 independently is M or Nle and X2 is any amino acid, pharmaceutical compositions comprising said peptide and use thereof for treating cancer.
US08383590B2	Peptide vaccines for cancers expressing tumor-associated antigens The present invention provides peptides having an amino acid sequence as set forth in SEQ ID NO: 19, 22, 30, 34, 344, 358, 41, 44, 46, 48, 78, 376, 379, 80, 100, 101, 110, 111, 387, 112, 394, 114, 116, 117, 121, 395, 133, 135, 137, 426, 143, 147, 148, 149, 150, 152, 153, 154, 156, 160, 161, 162, 163, 166, 174, 178, 186, 194, 196, 202, 210, 213, 214, 217, 223, 227, 228, 233, 254, 271, 272 or 288, as well as peptides having the above-mentioned amino acid sequences in which 1, 2, or several (e.g., up to 5) amino acids are substituted, deleted, or added, provided the peptides possess cytotoxic T cell inducibility. The present invention also provides drugs for treating or preventing a disease associated with over-expression of the CDH3, EPHA4, ECT2, HIG2, INHBB, KIF20A, KNTC2, TTK and/or URLC10, e.g. cancers containing as an active ingredient one or more of these peptides. The peptides of the present invention find further utility as vaccines.
US08383586B2	Compositions and methods for soft tissue repair Methods and compositions for treating soft tissue defects are provided. The composition, which is injectable directly into the tissue adjacent to the defect, comprises a fibrosis inducing factor in a carrier. The method includes preparing the composition comprising a fibrosis inducing factor in a carrier and delivering the composition into the tissue adjacent to the defect. Alternatively, a carrier matrix may be disposed in or near the defect, a pump capable of delivering an effective amount of a fibrosis inducing factor may be provided, and the pump is fluidly connected to the carrier matrix.
US08383584B2	HCV inhibiting macrocyclic phenylcarbamates Compounds of the formula I: including a stereoisomer thereof, or an N-oxide, a pharmaceutically acceptable addition salt, or a pharmaceutically acceptable addition solvate thereof; useful as HCV inhibitors; processes for preparing these compounds as well as pharmaceutical compositions comprising these compounds as active ingredient.
US08383579B2	Method for customized dispensing of variable dose drug combination products for individualizing of therapies Generally the method involves identifying the concentration of each of two or more active therapeutics tailored to treat a particular patient's unique metabolism and one or more diseases, communicating that information to a producer who has multiple fixed or variable concentrations of each active available, where the producer then combines the individual concentrations of each active into single units such as a tablets or pills, and distributes those indirectly or directly to the patient.
US08383577B2	Octreotide implant having a release agent Methods, formulations and kits are described that allow for the controlled release of octreotide, e.g., octreotide acetate, in a subject.
US08383575B2	(DI)barnase-barstar complexes A complex comprising barnase bound with high affinity to barstar, and comprising a therapeutic and/or diagnostic agent bound to barnase and/or barstar.
US08383574B2	Perfume composition The present invention relates to a perfume composition as a raw material of fruity perfumes which has a conventionally unknown peculiar fresh, woody, floral, grassy-leafy nuance and is capable of harmonizing with various perfumes to provide perfume preparations having a more sophisticated odor or scent. The perfume composition of the present invention includes a compound represented by the general formula (I): wherein R1 and R2 are each independently a hydrocarbon group having 1 to 4 carbon atoms; and R3 is a hydrocarbon group having 2 to 4 carbon atoms.
US08383572B2	Detergent composition containing suds boosting and suds stabilizing modified biopolymer New cleaning compositions including novel suds boosting and stabilization biopolymers containing alkoxy, anionic and nitrogen containing substitution are disclosed. In particular, cleaning compositions including suds boosting and stabilization biopolymers containing modified polysaccharides having alkoxy, anionic and nitrogen containing substitution and methods of forming the same are disclosed.
US08383570B2	Enhanced melting point rinse aid solid compositions with synergistic preservative The invention includes a GRAS preservative system including sodium bisulfate and a combination of specific organic acids that act in a synergistic capacity. The preservative further has the benefit of a higher melting point of approximately 110° or higher making it particularly suited for solid wash applications. According to the invention it has surprisingly been found that a combination of sodium bisulfate, sorbic acid, and benzoic acid produced better preservative properties than other organic acid combinations or each acid by itself.
US08383569B2	Cleaner composition A single phase alkaline composition comprising by weight about 10 to about 25 percent of nonionic surfactant blend comprising a ratio of between about 1:1 to about 1:2 of alcohol ethoxylate:fatty alcohol alkoxylate, about 3-10% of at least one water soluble solvent, about 1-10% of a chelant, 2-12% of an alkalinity source, 0.5-2% of an anionic surfactant blend comprised of at least about 40-70% of a sulfosuccinate, the balance being water. Compositions of the invention are useful for removing hydrophobic soils or oils whether they are located on a hard surface or on a linen. A method of cleaning a hard surface is also disclosed comprising the steps of diluting the composition of the invention with water to about 1 to about 3 weight percent, applying the diluted composition to the surface, and wiping the surface, wherein the surface is substantially free of oil or residue and the surface is substantially free of corrosion.
US08383568B2	Polyol oxidases The present invention provides compositions and methods for producing a polyol oxidase in micoroorganisms, and the use of polyol oxidases in cleaning compositions. The invention includes cleaning compositions that contain combinations of two or more POx oxidases, and cleaning compositions that contain combinations of two or more POx oxidases and a perhydrolase. In particular, the invention provides methods for expressing polyol oxidases in bacterial hosts for use in detergent applications for cleaning, bleaching and disinfecting.
US08383567B2	Cellulase-free enzyme compositions and host cells for producing the same The present invention provides recombinant bacterial cells for producing a detergent-additive protein. In some embodiments, the cells are of the genus Bacillus. In additional embodiments, the cells comprise a genome comprising an inactivated bglC gene, as well as a recombinant nucleic acid for production of at least one secreted detergent-additive protein. In some preferred embodiments, the secreted detergent-additive protein is a protease. The present invention also provides methods of using the bacterial cells to produce at least one detergent-additive protein, as well as cellulase-free compositions containing at least one detergent-additive protein.
US08383558B2	Oilwell sealant compositions comprising alkali swellable latex Sealant compositions comprising an alkali swellable latex and a pH increasing material and methods of using the same to service a wellbore are provided. In one embodiment, the sealant composition can be used in a wellbore and includes an alkali swellable latex and a pH increasing material. The sealant composition can have a pH of from about 7 to about 14. In other embodiments, the pH increasing material includes a base-producing material. The base-producing material can include alkali and alkali earth metal carbonates, alkali and alkali earth metal bicarbonates, alkali and alkali earth metal hydroxides, alkali and alkali earth metal oxides, alkali and alkali earth metal phosphates, alkali and alkali earth metal hydrogen phosphates, alkali and alkaline earth metal sulphides, alkali and alkaline earth metal salts of silicates, alkali and alkaline earth metal salts of aluminates, water soluble or water dispersible organic amines, polymeric amine, amino alcohols, or combinations thereof.
US08383555B2	Well fluid comprising a fluorinated liquid phase The present invention relates to a well drilling, completion or workover fluid wherein the continuous phase of the fluid essentially consists of a liquid fluorinated compound. In a variant, the liquid fluorinated compound is a perfluorinated compound.
US08383553B2	Dyes Novel dyes, as well as related photovoltaic cells, components, systems, and methods, are disclosed.
US08383548B2	Stable mixtures of microencapsulated and non-encapsulated pesticides The present invention is directed to a composition comprising i) a microencapsulated pesticide, ii) a dispersant selected from the group consisting of a lignin, b) a lignosulfonate salt and c) a lignosulfonate salt combined with the sodium salt of substituted naphthalene sulfonate formaldehyde polymer, iii) a salt selected from the group consisting of magnesium sulfate, sodium chloride, sodium nitrate and calcium chloride, and iv) a non-encapsulated pesticide. The present invention is also directed to methods of making and using the compositions of the present invention.
US08383540B2	Catalyst composition with halo-malonate internal electron donor and polymer from same Disclosed herein are procatalyst compositions, catalyst compositions and polymers, i.e., propylene-based polymers, produced therefrom. The present procatalyst compositions contain a halo-malonate and a 2-fluoro-malonate in particular. The present catalyst compositions improve catalyst selectivity, improve catalyst activity, and also improve hydrogen response during polymerization. Propylene-based polymer produced from the present catalyst composition has a melt flow rate greater than 50 g/10 min.
US08383539B2	Fiber manufacturing method, fiber manufacturing apparatus and proton-exchange membrane fuel cell A carried material is carried only on a surface of nano-fibers. It includes a raw material liquid spray step that sprays raw material liquid, which is a raw material of nano-fibers, into a space, a raw material liquid electrically charging step, which applies an electric charge to the raw material liquid and makes the raw material liquid electrically charged, a nano-fiber manufacturing step that manufactures the nano-fibers by having the electrically charged and sprayed raw material liquid explode electrostatically, a carried material electrically charging step that electrically charges a carried material carried on the nano-fibers with a polarity opposite to a polarity of the electrically charged nano-fibers, and a mixing step that mixes the manufactured nano-fibers and the electrically charged carried material in a space.
US08383537B2	Refractory materials Refractory materials are provided which contain P2O5/R2O3 constituents, where R is Y, Sc, Er, Lu, Yb, Tm, Ho, Dy, Tb, Gd, or a combination thereof, and/or V2O5/R′2O3 constituents where R′ is Y, Sc, one or more rare earth elements, or a combination thereof. In certain embodiments, the refractory materials are xenotime-type materials and/or xenotime-stabilized zircon-type materials. The refractory materials can be used in the manufacture of glass and glass-ceramics. For example, the refractory materials, especially those that contain P2O5/R2O3 constituents, can be used as forming structures (“isopipes”) in the fusion process for making flat sheets of glass such as the glass sheets used as substrates in the manufacture of flat panel displays.
US08383536B2	Dielectric ceramic and laminated ceramic capacitor A dielectric ceramic which is capable of achieving a laminated ceramic capacitor with high reliability, in particular, favorable lifetime characteristics in a load test, even when a dielectric ceramic layer is reduced in thickness contains one of (Ba,R)(Ti,Mn)O3 and (Ba,Ca,R)(Ti,Mn)O3 (R being La, Ce, Pr, Nd, Sm, Eu, Gd, Tb, Dy, Ho, Er, Tm, Yb, Lu, and/or Y) as a main component, and M (M being Fe, Co, V, W, Cr, Mo, Cu, Al, and/or Mg) and Si as accessory components. The area of a region in which M is present is 10% or less on average of a cross section of each main component grain.
US08383531B2	Glass flake A glass flake of the present invention has a composition that includes, in terms of mass %, 59≦SiO2<65, 8≦Al2O3≦15, 47<(SiO2—Al2O3)≦57, 1≦MgO≦5, 20≦CaO≦30, 0<(Li2O+Na2O+K2O)<2, and 0≦TiO2≦5 and that is substantially free from B2O3, F, ZnO, BaO, SrO, and ZrO2.
US08383529B2	Cellulose nonwoven fabric Disclosed is a cellulose nonwoven fabric containing cellulose fibers having a maximum fiber diameter of not more than 1500 nm and a crystallinity determined by solid state NMR techniques of not less than 60%. The porosity of the cellulose nonwoven fabric is not less than 40% and not more than 99%.
US08383528B2	Burn protective materials A method is described for reducing the afterflame of a flammable, meltable material. A textile composite is described comprising an outer textile comprising a flammable, meltable material, and a heat reactive material comprising a polymer resin-expandable graphite mixture.
US08383527B2	Antimicrobial composite An antimicrobial composite which comprises a first, liquid-permeable layer which is substantially completely bonded to a second liquid-absorbing layer. The first layer comprises a coating of at least one antimicrobial metal as such on the side which is bonded to the second layer. Substantially no antimicrobial metal in elemental form is present on exterior surfaces of the composite.
US08383526B2	Sheet for total heat exchanger A liquid containing a hydrophilic polymer is applied by spreading or impregnation to a porous sheet comprising paper or a nonwoven fabric containing not less than 30% by weight and not more than 100% by weight of hydrophilic fiber to provide a hydrophilic polymer-processed sheet of which the surface and/or the interior of the porous sheet is filled with the hydrophilic polymer, which is made insoluble to water. This sheet is used as a sheet for a total heat exchanger which has higher conductivity of sensible heat and latent heat than conventional sheet for a total heat exchanger that uses a moisture permeable membrane.
US08383524B2	Semiconductor device manufacturing method A semiconductor device manufacturing method includes forming a transistor over a semiconductor substrate; forming a first silicon nitride film covering the transistor over the semiconductor substrate; supplying a NH4F radical to the first silicon nitride film; making thermal processing on the first silicon nitride film after the supplying the NH4F radical; and forming a second silicon nitride film over the first silicon nitride film after the thermal processing.
US08383523B2	Method for texturing silicon wafers, treatment liquid therefor, and use In a method for the treatment of silicon wafers in the production of solar cells, a treatment liquid is applied to the surface of the silicon wafers for the purpose of texturization thereof. The treatment liquid contains, as additive, ethyl hexanol or cyclohexanol in an amount ranging from 0.5% to 3%, by weight.
US08383516B2	Semiconductor device and method for manufacturing the same A semiconductor device which has a semiconductor substrate, an isolation insulating film formed in the semiconductor substrate, a conductive pattern formed over the semiconductor substrate and the isolation insulating film, so that a side face of the conductive pattern is formed over the isolation insulating film, and an insulating film is formed over the isolation insulating film, the conductive pattern and the side face of the conductive pattern, and the side face of the conductive pattern comprises a notch.
US08383515B2	Methodology for wordline short reduction The method of forming a wordline is provided in the present invention. The proposed method includes steps of: (a) providing a plurality of SASTIs with a plurality of first POLY cells deposited thereon; and (b) depositing a first fill-in material having a relatively high etching rate oxide-like material in the plurality of SASTIs and on each side wall of the plurality of first POLY cells.
US08383513B2	Asymmetric rapid thermal annealing to reduce pattern effect Rapid thermal annealing methods and systems for annealing patterned substrates with minimal pattern effect on substrate temperature non-uniformity are provided. The rapid thermal annealing system includes a front-side heating source and a backside heating source. The backside heating source of the rapid thermal annealing system supplies a dominant amount of heat to bring the substrate temperature to the peak annealing temperature. The front-side heating source contributes to heat up the environment near the front-side of the substrate to a temperature lower than about 100° C. to about 200° C. less than the peak annealing temperature. The asymmetric front-side and backside heating for rapid thermal annealing reduce or eliminate pattern effect and improve WIW and WID device performance uniformity.
US08383509B2	Manufacture method for semiconductor device having improved copper diffusion preventive function of plugs and wirings made of copper or copper alloy and semiconductor device of this kind (a) A copper alloy film containing at least two types of metal elements in addition to copper is formed on the surface of an insulator containing oxygen and formed on a semiconductor substrate. (b) A metal film made of pure copper or copper alloy is formed on the copper alloy film. (c) After the step (a) or (b), heat treatment is performed under the condition that a metal oxide film is formed on a surface of the insulator through reaction between the oxygen in the insulator and the metal elements in the copper alloy film.
US08383505B2	Solder ball contact susceptible to lower stress A solder ball contact and a method of making a solder ball contact includes: a first insulating layer with a via formed on an integrated circuit (IC) chip and a metal pad; an under bump metallurgy (UBM) structure disposed within the via and on a portion of the first insulating layer, surrounding the via; a second insulating layer formed on an upper surface of an outer portion of the UBM structure that is centered on the via; and a solder ball that fills the via and is disposed above an upper surface of an inner portion of the UBM structure that contacts the via, in which the UBM structure that underlies the solder ball is of a greater diameter than the solder ball.
US08383502B2	Integrated high-K/metal gate in CMOS process flow A method of fabricating a semiconductor device includes providing a semiconductor substrate having a first active region and a second active region, forming a first metal layer over a high-k dielectric layer, removing at least a portion of the first metal layer in the second active region, forming a second metal layer on first metal layer in the first active region and over the high-k dielectric layer in the second active region, and thereafter, forming a silicon layer over the second metal layer. The method further includes removing the silicon layer from the first gate stack thereby forming a first trench and from the second gate stack thereby forming a second trench, and forming a third metal layer over the second metal layer in the first trench and over the second metal layer in the second trench.
US08383501B2	Vertical field effect transistor arrays and methods for fabrication thereof Vertical field effect transistor semiconductor structures and methods for fabrication of the vertical field effect transistor semiconductor structures provide an array of semiconductor pillars. Each vertical portion of each semiconductor pillar in the array of semiconductor pillars has a linewidth greater than a separation distance to an adjacent semiconductor pillar. Alternatively, the array may comprise semiconductor pillars with different linewidths, optionally within the context of the foregoing linewidth and separation distance limitations. A method for fabricating the array of semiconductor pillars uses a minimally photolithographically dimensioned pillar mask layer that is annularly augmented with at least one spacer layer prior to being used as an etch mask.
US08383500B2	Semiconductor device formed by a replacement gate approach based on an early work function metal In a replacement gate approach, one work function metal may be provided in an early manufacturing stage, i.e., upon depositing the gate layer stack, thereby reducing the number of deposition steps required in a later manufacturing stage. Consequently, the further work function metal and the electrode metal may be filled into the gate trenches on the basis of superior process conditions compared to conventional replacement gate approaches.
US08383496B2	Plasma doping method and manufacturing method of semiconductor device A plasma doping method capable of introducing impurities into an object to be processed uniformly is supplied. Plasma of a diborane gas containing boron, which is a p-type impurity, and an argon gas, which is a rare gas, is generated, and no bias potential is applied to a silicon substrate. Thereby, the boron radicals in the plasma are deposited on the surface of the silicon substrate. After that, the supply of the diborane gas is stopped, and bias potential is applied to the silicon substrate. Thereby, the argon ions in the plasma are radiated onto the surface of the silicon substrate. The radiated argon ions collide with the boron radicals, and thereby boron radicals are introduced into the silicon substrate. The introduced boron radicals are activated by thermal processing, and thereby a p-type impurity diffusion layer is formed in the silicon substrate.
US08383495B2	Semiconductor layer structure and method for fabricating a semiconductor layer structure Semiconductor layer structure and a method for producing a structure are provided, including a substrate made of semiconductor material, on which a layer made of a second semiconductor material is situated, furthermore a region (3) enriched with impurity atoms, which region is situated either in layer (2) or at a specific depth below the interface between layer (2) and substrate (1), additionally a layer (4) within the region (3) enriched with impurity atoms, which layer comprises cavities produced by ion implantation, furthermore at least one epitaxial layer (6) applied to layer (2) and also a defect region (5) comprising dislocations and stacking faults within the layer (4) comprising cavities, the at least one epitaxial layer (6) being largely crack-free, and a residual strain of the at least one epitaxial layer (6) being less than or equal to 1 GPa.
US08383487B2	Method for manufacturing SOI substrate Forming an insulating film on a surface of the single crystal semiconductor substrate, forming a fragile region in the single crystal semiconductor substrate by irradiating the single crystal semiconductor substrate with an ion beam through the insulating film, forming a bonding layer over the insulating film, bonding a supporting substrate to the single crystal semiconductor substrate by interposing the bonding layer between the supporting substrate and the single crystal semiconductor substrate, dividing the single crystal semiconductor substrate at the fragile region to separate the single crystal semiconductor substrate into a single crystal semiconductor layer attached to the supporting substrate, performing first dry etching treatment on a part of the fragile region remaining on the single crystal semiconductor layer, performing second dry etching treatment on a surface of the single crystal semiconductor layer subjected to the first etching treatment, and irradiating the single crystal semiconductor layer with laser light.
US08383486B2	Method of manufacturing a semiconductor device including a stress film A semiconductor device includes a first-type internal stress film formed of a silicon oxide film over source/drain regions of an nMISFET and a second-type internal stress film formed of a TEOS film over source/drain regions of a pMISFET. In a channel region of the nMISFET, a tensile stress is generated in the direction of movement of electrons due to the first-type internal stress film, so that the mobility of electrons is increased. In a channel region of the pMISFET, a compressive stress is generated in the direction of movement of holes due to the second-type internal stress film, so that the mobility of holes is increased.
US08383484B2	Semiconductor device production method A semiconductor device production method includes: forming a gate insulating film on the p-type region of a semiconductor substrate; forming a first aluminum oxide film with an oxygen content lower than stoichiometric composition on the gate insulating film; forming a tantalum-nitrogen-containing film that contains tantalum and nitrogen on the first aluminum oxide film; forming an electrically conductive film on the tantalum-nitrogen-containing film; patterning the electrically conductive film to form a gate electrode; injecting n-type impurities into the p-type region using the gate electrode as a mask; and carrying out heat treatment after the formation of the tantalum-nitrogen-containing film.
US08383483B2	High performance CMOS circuits, and methods for fabricating same The present invention relates to complementary metal-oxide-semiconductor (CMOS) circuits that each contains at least a first and a second gate stacks. The first gate stack is located over a first device region (e.g., an n-FET device region) in a semiconductor substrate and comprises at least, from bottom to top, a gate dielectric layer, a metallic gate conductor, and a silicon-containing gate conductor. The second gate stack is located over a second device region (e.g., a p-FET device region) in the semiconductor substrate and comprises at least, from bottom to top, a gate dielectric layer and a silicon-containing gate conductor. The first and second gate stacks can be formed over the semiconductor substrate in an integrated manner by various methods of the present invention.
US08383481B2	Semiconductor memory device and method of manufacturing the same In one embodiment, a method of manufacturing a semiconductor memory device is disclosed. The method can comprise forming a tunnel insulating film on a substrate, forming a charge storage layer including a conductor on the tunnel insulating film, forming an isolation trench which isolate the charge storage layer and the tunnel insulating film in the substrate, embedding an isolation insulating film in the isolation trench, removing a native oxide film which is formed on a surface of the charge storage layer, and forming an insulating film on a surface of the isolation insulating film and the surface of the charge storage layer. The process from the removing the native oxide film to the forming the insulating film carried out in a manufacture apparatus in which an oxygen concentration is controlled.
US08383477B2	Semiconductor device including vertical transistor and method for manufacturing the same A semiconductor device including a vertical transistor and a method for manufacturing the same may reduce a cell area in comparison with a conventional layout of 8F2 and 6F2. Also, the method does not require forming a bit line contact, a storage node contact or a landing plug, thereby decreasing the process steps. The semiconductor device including a vertical transistor comprises: an active region formed in a semiconductor substrate; a bit line disposed in the lower portion of the active region; a word line buried in the active region; and a capacitor disposed over the upper portion of the active region and the word line.
US08383474B2	Thin channel device and fabrication method with a reverse embedded stressor A device and method for inducing stress in a semiconductor layer includes providing a substrate having a dielectric layer formed between a first semiconductor layer and a second semiconductor layer. A removable buried layer is provided on or in the second semiconductor layer. A gate structure with side spacers is formed on the first semiconductor layer. Recesses are formed down to the removable buried layer in areas for source and drain regions. The removable buried layer is etched away to form an undercut below the dielectric layer below the gate structure. A stressor layer is formed in the undercut, and source and drain regions are formed.
US08383471B1	Self aligned sidewall gate GaN HEMT A method of fabricating a GaN HEMT includes growing a first epitaxial layer on a substrate, growing a second epitaxial layer on the first epitaxial layer, growing a third epitaxial layer on the second epitaxial layer, depositing a first dielectric film on the third epitaxial layer, using dielectric films to form a first sidewall dielectric spacer, forming a sidewall gate adjacent the first sidewall dielectric spacer. The sidewall gate may be made to be less than 50 nm in length.
US08383470B2	Thin film transistor (TFT) having a protective layer and manufacturing method thereof One of factors that increase the contact resistance at the interface between a first semiconductor layer where a channel is formed and source and drain electrode layers is a film with high electric resistance formed by dust or impurity contamination of a surface of a metal material serving as the source and drain electrode layers. As a solution, a first protective layer and a second protective layer including a second semiconductor having a conductivity that is less than or equal to that of the first semiconductor layer is stacked successively over source and drain electrode layers without exposed to air, the stack of films is used for the source and drain electrode layers.
US08383466B2	Display device and method of manufacturing the same A substrate comprising a thin-film-transistor (TFT) region, a pixel region, a gate-line region and a data-line region is provided. A transparent conductive layer and a first metal layer are orderly formed on the substrate. A conductive stack layer is formed within each of the TFT/pixel/gate-line regions and the end of the data-line region. Next, a first insulating layer and a semiconductor layer are orderly formed, and a patterned first insulating layer and a patterned semiconductor layer are formed above the conductive stack layer within the TFT region. Then, a second metal layer and a first photoresist layer are respectively formed. Afterwards, the second and the first metal layers are patterned by using the first photoresist layer as a photomask. Finally, the first photoresist layer is reflowed by heat, and part of the reflowed first photoresist layer covers a channel formed within the TFT region.
US08383465B2	Semiconductor device and manufacturing method thereof An oxide or nitride semiconductor layer is formed over a substrate. A first conductive layer including a first element and a second element, and a second conductive layer including the second element are formed over the semiconductor layer. The first element is oxidized or nitrogenized near an interface region between the first conductive layer and the oxide or nitride semiconductor layer by heat treatment or laser irradiation. The Gibbs free energy of oxide formation of the first element is lower than those of the second element or any element in the oxide or nitride semiconductor layer.
US08383464B2	Method for producing field effect transistors with a back gate and semiconductor device The method for producing a field effect transistor on a substrate comprising a support layer, a sacrificial layer and a semi-conducting layer comprises forming an active area in the semi-conducting layer. The active area is delineated by a closed peripheral insulation pattern and comprises an additional pattern made from insulating material. The method also comprises etching the insulating material of the additional pattern to access the sacrificial layer, etching the sacrificial layer resulting in formation of a first cavity, forming a dielectric layer on a top wall of the first cavity, and depositing an electrically conducting layer in the first cavity. The closed peripheral insulation pattern is formed through the semi-conducting layer and the sacrificial layer.
US08383462B2	Method of fabricating an integrated circuit package A method of manufacturing a ball grid array, BGA, integrated circuit package, comprising forming a double sided printed circuit board, PCB, with blind vias interconnecting electrically the circuits on the opposed surfaces of the PCB, with at least one through-hole to allow fluid or gas to pass through the PCB, and an integrated circuit connected to the printed circuit on one side of the PCB; soldering a lid onto the said one side of the PCB to enclose the integrated circuit, whilst allowing thermally expanding gas or fluid to escape through the or each through-hole, whereby to form a package which is hermetically sealed except for the or each through-hole, and which has a cavity between the integrated circuit and the lid; applying a BGA to the side of the PCB opposed to the said one side, whereby to solder the balls of the BGA to respective portions of the printed circuit and to align one of the balls axially with each through-hole; and soldering the ball or balls into the through-hole, or into each respective through-hole, to hermetically seal the package.
US08383458B2	Integrated circuit package system employing an offset stacked configuration and method for manufacturing thereof A method for manufacturing an integrated circuit package system includes: providing a base package including a first integrated circuit coupled to a base substrate by an electrical interconnect formed on one side; and mounting an offset package over the base package, the offset package electrically coupled to the base substrate via a system interconnect.
US08383457B2	Semiconductor device and method of forming interposer frame over semiconductor die to provide vertical interconnect A semiconductor device has a first semiconductor die mounted over a carrier. An interposer frame has an opening in the interposer frame and a plurality of conductive pillars formed over the interposer frame. The interposer is mounted over the carrier and first die with the conductive pillars disposed around the die. A cavity can be formed in the interposer frame to contain a portion of the first die. An encapsulant is deposited through the opening in the interposer frame over the carrier and first die. Alternatively, the encapsulant is deposited over the carrier and first die and the interposer frame is pressed against the encapsulant. Excess encapsulant exits through the opening in the interposer frame. The carrier is removed. An interconnect structure is formed over the encapsulant and first die. A second semiconductor die can be mounted over the first die or over the interposer frame.
US08383455B2	Electronic device including an organic active layer and process for forming the electronic device An electronic device can include an organic active layer and an electrode. In one aspect, the electrode can further include a first layer that is conductive, and a second layer that is conductive. The second layer can include a defect extending at least partly through a thickness of the second conductive layer. The electrode can also include a third layer lying within and substantially filling the defect, wherein each of the second and third layers includes a same metallic element.In another aspect, a process for forming an electronic device can include forming an organic active layer and forming a first layer that is conductive and is part of an electrode. The process can also include forming a second layer and exposing the second layer to a first plasma to form a first compound from the second layer.
US08383452B2	Semiconductor device and method for manufacturing the same In one embodiment, a method for manufacturing a semiconductor device is disclosed. The method can include depositing a first amorphous film having a first impurity, depositing a third amorphous lower-layer film on the first amorphous film, forming microcrystals on the third amorphous lower-layer film, depositing a third amorphous upper-layer film on the third amorphous lower-layer film to cover the microcrystals, depositing a second amorphous film having a second impurity on the third amorphous upper-layer film, and radiating microwaves to crystallize the third amorphous lower-layer film and the third amorphous upper-layer film to form a third crystal layer, and crystallize the first amorphous film and the second amorphous film to form a first crystal layer and a second crystal layer.
US08383451B2	Deposition of photovoltaic thin films by plasma spray deposition In particular embodiments, a method is described for depositing thin films, such as those used in forming a photovoltaic cell or device. In a particular embodiment, the method includes providing a substrate suitable for use in a photovoltaic device and plasma spraying one or more layers over the substrate, the grain size of the grains in each of the one or more layers being at least approximately two times greater than the thickness of the respective layer.
US08383449B2	Method of forming a thin film transistor having openings formed therein A thin film transistor array panel includes a substrate, a plurality of first and second signal lines crossing each other on the substrate, source electrodes connected to the first signal lines, drain electrodes connected to the second signal lines, pixel electrodes connected to the drain electrodes, a first partition formed on the source and drain electrodes and having a first opening, wherein a lower width of the first opening is wider than an upper width of the first opening, an organic semiconductor formed in the first opening and at least overlapping the portions of the source electrode and the drain electrode, and a gate electrode connected to the second signal line and at least overlapping the portion of the organic semiconductor.
US08383448B2	Method of fabricating metal oxide semiconductor device A method of fabricating an MOS device is provided. First, gates and source/drain regions of transistors are formed on a substrate. A photodiode doped region and a floating node doped region are formed in the substrate. Thereafter, a spacer stacked layer including a bottom layer, an inter-layer and a top layer is formed to cover each gate of the transistors. Afterwards, a first mask layer having an opening exposing at least the photodiode doped region is formed on the substrate, and then the top layer exposed by the opening is removed. Next, the first mask layer is removed, and then a second mask layer is formed on a region correspondingly exposed by the opening. A portion of the top layer and the inter-layer exposed by the second mask layer is removed to form spacers on sidewalls of the gates.
US08383445B2	Method and device for CMOS image sensing with multiple gate oxide thicknesses A method and device for image sensing. The method includes forming a first well and a second well in a substrate, forming a gate oxide layer with at least a first part and a second part on the substrate, and depositing a first gate region and a second gate region on the gate oxide layer. The first part of the gate oxide layer is associated with a first thickness, and the second part of the gate oxide layer is associated with a second thickness. The first thickness and the second thickness are different. The first gate region is located on the first part of the gate oxide layer associated with the first thickness, while the second gate region is located on both the first part of the gate oxide layer associated with the first thickness and the second part of the gate oxide layer associated with the second thickness. The first gate region is associated with the first well, and the second gate region is associated with the second well. Additionally, the method includes forming a third well in the substrate, implanting a first plurality of ions to form a first lightly doped source region and a first lightly doped drain region in the first well, implanting a second plurality of ions to form at least a second lightly doped drain region in the second well, and implanting a third plurality of ions to form a source in the second well.
US08383444B2	Method for determining color using CMOS image sensor A method is provided for determining a color using a CMOS image sensor. The CMOS image sensor includes an n-type substrate and a p-type epitaxy layer overlying the n-type substrate. The method includes applying a first voltage on the n-type substrate and obtaining a first output, which is associated with the first voltage. The method further includes applying a second voltage on the n-type substrate and obtaining a second output, which is associated with the second voltage. The method additionally includes applying a third voltage on the n-type substrate and obtaining a third output, which is associated with the third voltage. The method also includes providing a plurality of weighting factors and determining the color based on the plurality of weighting factors, the first output, the second output, and the third output.
US08383442B2	Methods for reduced stress anchors Methods of anchoring components of a Micro-Electro-Mechanical Systems (MEMS) device to a substrate. An exemplary embodiment has a trace anchor bonded to a substrate, a device anchor bonded to the substrate, and an anchor flexure configured to flexibly couple the trace anchor and the device anchor to substantially prevent transmission of a stress induced in the trace anchor from being transmitted to the device anchor.
US08383440B2	Light shield for CMOS imager System and method for providing a light shield for a CMOS imager is provided. The light shield comprises a structure formed above a point between a photo-sensitive element and adjacent circuitry. The structure is formed of a light-blocking material, such as a metal, metal alloy, metal compound, or the like, formed in dielectric layers over the photo-sensitive elements.
US08383435B2	Integrated photonic semiconductor devices and methods for making integrated photonic semiconductor devices A photonic semiconductor device and method are provided that ensure that the surface of the device upon completion of the SAG process is planar, or at least substantially planar, such that performance of the subsequent processes is facilitated, thereby enabling higher manufacturing yield to be achieved. A photonic semiconductor device and method are also provided that ensure that the isolation region of the device will have high resistance and low capacitance, without requiring the placement of a thick dielectric material beneath each of the contact pads. Eliminating the need to place thick dielectric materials underneath the contact pads eliminates the risk that the contact pads will peel away from the assembly.
US08383427B2	Semiconductor device including a magnetic tunnel junction device including a laminated structure and manufacturing method therefor A semiconductor device having a MTJ device excellent in operating characteristics and a manufacturing method therefor are provided. The MTJ device is formed of a laminated structure which is obtained by laminating a lower magnetic film, a tunnel insulating film, and an upper magnetic film in this order. The lower and upper magnetic films contain noncrystalline or microcrystalline ferrocobalt boron (CoFeB) as a constituent material. The tunnel insulating film contains aluminum oxide (AlOx) as a constituent material. A CAP layer is formed over the upper magnetic film and a hard mask is formed over the CAP layer. The CAP layer contains a substance of crystalline ruthenium (Ru) as a constituent material and the hard mask contains a substance of crystalline tantalum (Ta) as a constituent material. The film thickness of the hard mask is larger than that of the CAP layer.
US08383420B2	Solid phase and catalyzed enabled automated isotope dilution and speciated isotope dilution mass spectrometry A method for the equilibration of enriched isotope species and natural isotope species prior to mass spectrometric analysis using solid phase and/or microwave isotope ratio equilibration and measurement.
US08383419B2	Harvesting target materials from centrifuged suspensions Embodiments of the present invention are directed to harvesting a target material from a suspension using a tube and float system. A suspension suspected of containing a target material is combined with a solution having one or more labels that distinguish the target material from other materials in the suspension. The tube, float, and suspension are centrifuged to separate various materials in the suspension according to associated specific gravities. The float expands the axial length of the target material layer and displaces the target material to a narrow space between the float and the inner wall of the tube. The space is illuminated with light that causes the labels to emit light identifying the location of the target material within the tube. One or more openings can then be formed in the tube at or near the point where the target material is located and the target material harvested.
US08383417B2	Assay for monitoring parathyroid hormone (PTH) variants by tandem mass spectrometry Methods are described for monitoring the amounts of PTH variants in a biological sample by digesting the sample to produce surrogate peptides specific to the targeted PTH variants, and detecting and quantifying the surrogate peptides by selective reaction monitoring (SRM) mass spectrometry, using a set of precursor-to-product ion transitions optimized for sensitivity and selectivity. The PTH variants, or a portion thereof, may be concentrated in the sample by means of immunoaffinity capture or other suitable technique. The mass spectrometric method described herein enables the concurrent measurement of peptides representative of a plurality of targeted PTH variants in a single assay.
US08383412B2	Sensors and switches for detecting hydrogen Sensors and switches for detecting hydrogen include an electrically-insulating support; a first and second electrode; and a palladium structure alone or in combination with an organic insulating film. The palladium structures of the sensors are deposited on and contact a first electrode and a portion of the palladium structure extends to and contacts the second electrode to create a conductive path. The palladium structures of the switches are deposited on and contact a first electrode and a portion of the palladium structures extend to and contact an organic insulating film deposited on the second electrode. Upon exposure of the switch to hydrogen, portions of the palladium structure extend through the film and contact the second electrode to create a conductive path. Methods of detecting hydrogen and methods of fabricating a sensor for detecting an analyte of interest are also provided.
US08383411B2	Specimen processing system and specimen conveyance method A specimen processing system comprising: a plurality of measurement units for acquiring a reagent from each of corresponding reagent containers, and performing measurement of a specimen for a common measurement item by using the reagent; a conveyance mechanism for conveying specimens to the measurement units; a reagent information acquirer for acquiring reagent information related to the reagent stored in each of the reagent containers; a conveying destination determiner for determining a conveying destination of specimens based on the reagent information acquired by the reagent information acquirer; and a conveyance controller for controlling the conveyance mechanism to convey specimens based on the conveying destination determined by the conveying destination determiner, is disclosed. Specimen conveyance method is also disclosed.
US08383410B2	C4d/C4b standard for quantitative flow cytometry of humoral transplant rejection The invention concerns an internal standard used to quantitative analysis of the risk of humoral (i.e. vascular) transplant rejection. The internal standard consists of a stable composition of the C4d complement bound to a carrier consisting of erythrocytes or microparticles. The invention also concerns a method for analyzing in vitro the risk of humoral organ transplant rejection, which consists in determining the amount of component of C4d component fixed on the erythrocytes contained in a blood sample from a patient.
US08383408B2	Nanofibrillar structure and applications including cell and tissue culture A nanofibrillar structure for cell culture and tissue engineering is disclosed. The nanofibrillar structure can be used in a variety of applications including methods for proliferating and/or differentiating cells and manufacturing a tissue. Also disclosed is an improved nanofiber comprising a lipid, lipophilic molecule, or chemically modified surface. The nanofibers can be used in a variety of applications including the formation of nanofibrillar structures for cell culture and tissue engineering.
US08383407B2	Percutaneous access device system facilitating cell growth thereon A process to facilitate growing of cells on a nanotextured percutaneous portal is provided that includes the placement of a nanotextured percutaneous portal partially within a subject. A vacuum manifold is secured to the nanotextured percutaneous portal. Upon coupling the vacuum manifold to a vacuum source, the growth of the cells is facilitated.
US08383403B2	Reticulocyte mimetics and method of preparation of the same In one aspect of the present disclosure there is provided a method for preparing reticulocyte mimetics. In another aspect of the present disclosure there are provided reticulocyte mimetics obtained using the method. In yet another aspect of the present disclosure there is provided a whole blood reference control including the reticulocyte mimetics as provided. In still another aspect of the present disclosure there is provided a composition useful for preparing reticulocyte mimetics.
US08383402B2	Trichoplusia ni cell line and methods of use An isolated cell from the cell line identified as TnT4. This cell may be infected with a baculovirus expression vector which may carry a heterologous nucleotide that encodes a polypeptide, such as a membrane protein, e.g., human neurotensin receptor 1. Also included is a method for using this cell line to produce a polypeptide, such as a membrane protein; and a method for identifying a cell-of-interest which expresses a protein-of-interest.
US08383400B2	Kits for producing recombinant polypeptides via cysteine protease autoprocessing of fusion proteins Disclosed are fusion proteins, polynucleotides that encode the disclosed fusion proteins, and methods for expressing and autoprocessing of the disclosed fusion proteins to obtain a target protein. The disclosed fusion proteins include an autoproteolytic cysteine protease fused to a heterologous polypeptide, which may be isolated as the target protein. Preferably, the protease activity of the cysteine protease is inducible. Suitable autoproteolytic cysteine proteases for the fusion proteins include the cysteine protease of the Vibrio cholerae RTX toxin.
US08383399B2	Nucleic acid construct having an ovalbumin promotor A transgenic avian containing in its genome an exogenous nucleotide sequence which includes a promoter component and a vector with reduced promoter interference wherein the exogenous nucleotide sequence is integrated into the genome and the avian.
US08383398B2	Expression vector A conventional shuttle vector constructed by fusing an E. coli-derived plasmid and a transformant-derived plasmid functions in both E. coli and the transformant bacterium, and there exists no expression vector that functions only in a non-E. coli transformant. The present invention provides an plasmid expression vector comprising (1) a plasmid replication unit that functions in an anaerobic microorganism other than E. coli and (2) a protein expression unit formed from DNA coding for a protein having target activity and a DNA fragment containing a promoter and a terminator that function in the anaerobic microorganism. The expression vector of the present invention is capable of being replicated only in a transformant, eliminating the risk of the replication of the transformant gene in other pathogenic or aerobic bacterium, providing an extremely safe and reliable vector and gene transporter for therapeutic application.
US08383390B2	Bacteria that reduce content of heavy metals in plant This invention relates to bacteria having a function of reducing the content of heavy metals in plants, a method for reducing the content of heavy metals in plants with the use of such bacteria, and a composition comprising, as an active ingredient, such bacteria.
US08383389B2	Hydroxynitrile lyase An improved hydroxynitrile lyase characterized by having a mutation of substitution of at least one amino acid residue in the amino acid sequence of a wild-type hydroxynitrile lyase with another amino acid and by its hydroxynitrile lyase activity per transformant being higher than the hydroxynitrile lyase activity per transformant into which the wild-type hydroxynitrile lyase gene is introduced; and a method for producing a hydroxynitrile lyase, comprising expressing the improved hydroxynitrile lyase in a host and recovering the improved hydroxynitrile lyase from the resultant culture.
US08383387B2	Subtilases The present invention relates to methods for producing variants of a parent TY145 subtilase and of a parent BPN′ subtilase and to TY145 and BPN′ variants having altered properties as compared to the parent TY145/BPN′ subtilase.
US08383381B2	Method for producing hydroxylated adaivjantane using cytochrome P450 Disclosed is a method for producing a hydroxylated form of a compound having an adamantane skeleton, which is useful as an intermediate for functional resins and pharmaceutical products, with high yield and at low cost. Specifically, a hydroxylated form of a compound having an adamantane skeleton can be obtained by using cytochrome P450. More specifically, an N-(5-hydroxy-2-adamantyl)-benzamide derivative can be produced by hydroxylating an N-(2-adamantyl)-benzamide derivative.
US08383380B2	Segmented polymers and their conjugates Segmented water soluble polymers, containing a higher molecular weight segment linked to a lower molecular weight segment, are described. In one embodiment, the polymer segments are poly(ethylene glycol) segments. The segmented polymers are functionalized and are useful for conjugation to various moieties such as pharmacologically active substances. Also described are conjugates of such polymers and methods of their preparation.
US08383379B2	Copolymer comprising 4-hydroxybutyrate unit and lactate unit and its manufacturing method The present invention relates to a copolymer comprising 4-hydroxybutyrate monomer unit and lactate monomer unit, a copolymer 4-hydroxybutyrate monomer unit, lactate monomer unit and 3-hydroxyalkanoate, or their preparing method. More specifically, the present invention relates to a method for preparing a copolymer comprising lactate monomer; 4-hydroxybutyrate monomer; and optionally 3-hydroxyalkanoate, wherein the method comprises culturing a cell or plant comprising the gene of enzyme converting lactate and 3-hydroxyalkanoate into lactyl-CoA and 3-hydroxyalkanoyl-CoA, respectively, phosphotransbutylase gene, butyrate kinase gene and polyhydroxyalkanoate synthase gene together, and the copolymer made by the method. The copolymer of the present invention is a biodegradable polymer being able to be usefully used instead of conventional synthetic plastic, and the copolymer can be used for medical use.
US08383374B2	Materials and methods for the efficient production of acetate and other products The subject invention provides materials and methods wherein unique and advantageous combinations of gene mutations are used to direct carbon flow from sugars to a single product. The techniques of the subject invention can be used to obtain products from native pathways as well as from recombinant pathways. In preferred embodiments, the subject invention provides new materials and methods for the efficient production of acetate and pyruvic acid.
US08383373B2	Process for preparing long-chain dicarboxylic acids The present invention particularly discovered strains that are capable of producing a long-chain dicarboxylic acid by culturing microorganisms belonging to Candida vini Candida entamophila, Candida blankii and Pichia farinosa which has the ability to produce a long-chain dicarboxylic acid in a liquid medium containing a straight-chain saturated hydrocarbon (tridecane) as substrate.
US08383372B2	L-cysteine producing bacterium and a method for producing L-cysteine The present invention describes a bacterium belonging to the family Enterobacteriaceae which has L-cysteine-producing ability and has been modified to decrease the activity of a protein encoded by the d0191 gene. This bacterium is cultured in a medium, and L-cysteine, L-cystine, derivatives thereof, or a mixture thereof is collected from the medium.
US08383363B1	L-amino acid-producing microorganism and method for producing L-amino acid L-amino acids are produced by culturing a microorganism which has an ability to produce the L-amino acid, but has been modified so that expression of the ybjE gene has been enhanced. The L-amino acid is collected from the culture medium or from the microorganism.
US08383358B2	Use of 2 anti-SPARC antibodies to predict response to melanoma chemotherapy The invention provides anti-SPARC antibody-based techniques for predicting a response to chemotherapy.
US08383357B2	Biological markers predictive of anti-cancer response to epidermal growth factor receptor kinase inhibitors The present invention provides diagnostic and prognostic methods for predicting the effectiveness of treatment of a cancer patient with an EGFR kinase inhibitor. Methods are provided for predicting the sensitivity of tumor cell growth to inhibition by an EGFR kinase inhibitor, comprising assessing whether the tumor cell has undergone an epithelial to mesenchymal transition (EMT), by determining the expression level of epithelial and/or mesenchymal biomarkers, wherein tumor cells that have undergone an EMT are substantially less sensitive to inhibition by EGFR kinase inhibitors. Improved methods for treating cancer patients with EGFR kinase inhibitors that incorporate the above methodology are also provided. Additionally, methods are provided for the identification of new biomarkers that are predictive of responsiveness of tumors to EGFR kinase inhibitors. Furthermore, methods for the identification of agents that restore the sensitivity of tumor cells that have undergone EMT to inhibition by EGFR kinase inhibitors are also provided.
US08383356B2	Electronic methods for the detection of analytes The present invention is directed to the detection of target analytes using electronic techniques, particularly AC techniques.
US08383354B2	Diagnostic method for atherosclerosis The invention relates to a method of identifying/monitoring active atherosclerotic plaques associated with blood vessel walls wherein the plaques comprise activated macrophages having accessible binding sites for a ligand. The method comprises the steps of administering to a patient being evaluated for atherosclerosis an effective amount of a composition comprising a conjugate of a ligand and a chromophore capable of emitting light under predetermined conditions, allowing sufficient time for the ligand conjugate to bind to the activated macrophages, subjecting the blood vessels to the predetermined conditions using a catheter-based device, and identifying active plaques by detecting light emitted by the chromophore using a catheter-based device or by using an external imaging technique. The invention also relates to a similar method wherein a chemical moiety capable of emitting radiation is conjugated to the ligand.
US08383349B2	Bone morphogenetic protein antagonist and uses thereof The present invention relates to the use of proteins that are differentially expressed in tumor associated stromal cells, as compared to normal stromal, as biomolecular targets for tumor treatment therapies. The present invention also provides compounds and pharmaceutically acceptable compositions for administration in the methods of the invention.
US08383348B2	Precircle probe nucleic acid amplification methods The invention is directed to novel methods of multiplexing nucleic acid reactions, including amplification, detection and genotyping. The invention relies on the use of precircle probes that are circularized in the presence of the corresponding target nucleic acids, cleaved, and then amplified.
US08383347B1	Method of diagnosing or assessing risk for Parkinson's disease or Alzheimer's disease using TCR clonality Changes in adaptive immune system were identified and correlated as a predictor of Aβ40 and Aβ42 and AD progression. T-cell, B-cell, TCR and BCR profiles were used to correlate clinical progression of AD. The CDR3 region was spectratyped, showing the clonality of the CDR3 region. This intrafamily gene fragment length profile was compared to age-matched controls, thereby indicating the existence of a neurodegenerative disease. The novel method is useful in diagnosing neurodegenerative disease, like Parkinson's disease, HIV-associated Dementia, or Alzheimer's disease. Moreover, this permits the clinical identification of patients at a very early stage of AD and/or monitoring the potential benefits of disease modifying therapeutics.
US08383346B2	Combined automated parallel synthesis of polynucleotide variants The present disclosure relates to methods for efficient synthesis, cloning, transformation and screening of large diverse libraries of polynucleotide variants comprising well-defined nucleotide differences relative to a reference polynucleotide.
US08383339B2	Liquid supramolecular nanostamping (LiSuNS) The present invention is directed to methods and materials for producing complements and reproductions of a master, including such preparation in a high throughput setting, using, inter-alia, liquid supramolecular nanostamping (LiSuNS).
US08383338B2	Methods and systems for uniform enrichment of genomic regions The present invention provides methods and compositions for the enrichment of target nucleic acids in a microarray system. In particular, the present invention provides methods and compositions for uniform enrichment of target nucleic acid molecules in a microarray format. The present invention also provides for intentionally non-uniform enrichment among target nucleic acid molecules.
US08383336B2	Antisense formulation A room temperature stable and minimal aggregate liquid formulation comprises an oligonucleotide comprising Seq ID No. 1: or comprising a variant oligonucleotide in which no more than 3 non-sequential bases are different from Seq. ID NO. 1 and an aqueous carrier comprising a aggregation-preventing compound selected from the group consisting of mono and disaccharides and/or sugar alcohols.
US08383332B2	Procalcitonin for the diagnosis of bacterial infections and guidance of antibiotic treatment in patients with acute stroke or transient ischemic attack The present invention relates to an in vitro method for the diagnosis and treatment guidance of a bacterial infection in patients suffering from an acute ischemic or hemorrhagic stroke, comprising the determination of the level of Procalcitonin (PCT) or a fragment thereof having at least 12 amino acid residues in a sample of a bodily fluid from said patient and the correlation of the determined level to the diagnosis of a bacterial infection in said patient.
US08383331B2	Silver halide photographic light-sensitive material for movie A silver halide photographic light-sensitive material for movie, having a specific layer structure by using particles of at least one kind of electroconductive metal oxide and at least one kind of an electroconductive polymer.
US08383330B2	Pattern exposure method and pattern exposure apparatus A belt-like work (11) provided with a photosensitive layer is conveyed in a work conveying direction F at a work conveying speed V. An illuminating section (30) illuminates a photomask (29) in an exposure period T synchronized with the work conveying speed V. The photomask (29) is disposed at a proximity gap from the belt-like work (11). Mask patterns (33) on the photomask (29) are exposed on the belt-like work (11) to form periodic patterns thereon.
US08383329B2	Pattern exposure method, conductive film producing method, and conductive film There are provided a pattern exposure method, a conductive film producing method, and a conductive film, wherein a photosensitive material is subjected to a proximity exposure through a photomask disposed with a proximity gap of 70 to 200 μm, and thereby is exposed in the mask pattern periodically in the conveying direction to obtain a conductive film. The conductive film has a plurality of conductive portions of first and second conductive thin metal wires and a plurality of opening portions. A side of each thin metal wire has a protrusion extending toward the opening portion from a virtual line representing a designed width of the thin metal wire, and the protruding amount of the protrusion is 1/25 to 1/6 of the designed width.
US08383327B2	Method for producing an electro-optical printed circuit board with optical waveguide structures An electro-optical printed circuit board contains electrical conductor tracks on the one hand and optical waveguide structures on the other hand. The optical waveguide structures comprise a bottom layer, a core layer and a cladding layer. Visible areas are applied to the printed circuit board, and the core layer is applied later both to the bottom layer as well as the visible areas and structured both on the bottom layer as well as the visible areas. This structure is then transferred to the visible areas, e.g. by etching. Reference marks are thus produced which contain the information on the actual position of the optical waveguide structures.
US08383325B2	Lithographic apparatus and method A lithographic method includes providing particles in dry form on a substrate, or on material provided on the substrate, irradiating one or more of the particles with a dose of radiation, the dose of radiation being sufficient to ensure that at least one particle of the one or more particles is bonded to the substrate, or to the material provided on the substrate, and removing particles from the substrate, or from material provided on the substrate, that have not been bonded to the substrate, or to the material provided on the substrate.
US08383323B2	Selective imaging through dual photoresist layers A system and method for selective imaging through dual photoresist layers. The system and method includes coating a surface of the wafer with a first resist and baking the wafer to sufficiently drive out solvents in the first resist. The first resist is exposed to a first radiation source and exposing an edge of the wafer having the first resist disposed thereon to the first radiation source. The method further includes hard baking the first resist to the wafer and coating the first resist with a second resist. The method also includes baking the wafer to sufficiently drive out solvents in the second resist and exposing the second resist to a second radiation source. The method also includes exposing select portions of the edge of the wafer having the second resist disposed thereon to the second radiation source and hard baking the second resist to the wafer.
US08383321B2	Method for developing a printing plate precursor A method for developing a printing plate precursor comprising the step of immersing the precursor in an aqueous alkaline developing solution comprising a (co)polymer comprising a monomeric unit which is represented by the following formula (I): wherein L is a linking group; R1, R2 and R3 independently represent hydrogen or an alkyl group; R4 represents an optionally substituted hydroxyaryl group; x=0 or 1; y=0 or 1 and when y=0 then x=1 and L is further bound to C* to form a cyclic structure.
US08383320B2	Resist underlayer film forming composition and method of forming resist pattern using the same There is provided a composition for forming a resist underlayer film not only having a large selection ratio of a dry etching rate but also exhibiting desired values of the k value and of the refractive index n at a short wavelength such as a wavelength of an ArF excimer laser. A resist underlayer film forming composition for lithography comprising: a linear polymer; and a solvent, wherein a backbone of the linear polymer has a unit structure in which 2,4-dihydroxy benzoic acid is introduced through an ester bond and an ether bond.
US08383317B2	Method of making carbon nanotube patterned film or carbon nanotube composite using carbon nanotubes surface-modified with polymerizable moieties Disclosed herein are methods of making a negative pattern of carbon nanotubes or a polymerized carbon nanotube composite having an interpenetrating polymer network (IPN) by modifying the surfaces of the carbon nanotubes with polymerizable functional groups such as oxirane and anhydride groups and subjecting the surface-modified carbon nanotubes either to a photolithography process or to a heatcuring process. By virtue of the present invention, desired patterns of carbon nanotubes can be easily made on the surfaces of various substrates, and polymerized carbon nanotube composites improved in hardening properties can be made without additional polymers.
US08383314B2	Photocurable liquid developer, method for producing the same, developing device and image forming apparatus To provide a photocurable liquid developer including colored resin particles, and an electrically insulating liquid that cures by light, wherein the electrically insulating liquid contains an unsaturated group-containing silicone compound represented by General Formula (1) below, where R independently denotes a methyl group or a phenyl group, l and m each independently denote an integer of 0 to 100, and X1, X2 and X3 each independently denote a C1-C6 alkyl group or Substituent A below, with at least one of X1, X2 and X3 being Substituent A, where R denotes a methyl group or a phenyl group, and n denotes an integer of 2 or 3.
US08383307B2	Toner, developer, and image forming method and apparatus using the toner The toner includes a binder resin; a release agent; a colorant; and a dispersing resin configured to disperse the release agent. The dispersing resin includes a polyhydroxycarboxylic acid unit obtained from an optically active monomer. The polyhydroxycarboxylic acid unit has an optical purity of not greater than 80%, wherein the optical purity is defined as the absolute value of difference between the mole percentage of a L-monomer in the optically active monomer and the mole percentage of a D-monomer in the optically active monomer.
US08383305B2	Image forming apparatus An image forming apparatus including a latent image bearing member, a charging device, a latent electrostatic image formation device, a development device, a transfer device, and a lubricant supplying device, the latent image bearing member satisfying (I), (II) and (III): \|(A1−B1)−(A2−B2)\|≦5.0 (I) B1≧1 (atomic %) (II) 1 (nm)≦X≦30 (nm) (III), where, by XPS analysis, A1 and B1 represent oxygen and silicon atom content ratio in a cross-linked surface layer, respectively, A2 represents oxygen atom content ratio in a surface dug through a cross-linked surface layer along a direction perpendicular to the latent image bearing member surface, to an electroconductive substrate at depth point X where B1 decreases to not greater than B1×0.5, and B2 represents the silicone atom content ratio in the surface at X.
US08383302B2	Colored curable composition, color filter and production method thereof, and solid-state imaging device A colored curable composition is provided which has desired transmittance properties, has stability in a state of a chemical solution such as dispersion uniformity or long-term viscosity stability, is excellent in developing properties and is capable of forming a color pattern with high resolving power. The colored curable composition includes (A) a monomer having an alkyleneoxy chain, (B) a binder polymer, (C) a photopolymerization initiator, and (D) Pigment Red 166.
US08383301B2	Methods of fabricating reticles with subdivided blocking regions Methods for designing, fabricating, and using attenuated phase shift reticles, or photomasks are disclosed. Methods are also disclosed for subdividing the radiation blocking regions of previously fabricated reticles of previously existing designs. The methods may include forming radiation blocking regions that are subdivided, by cut lines, into discrete, spaced apart sections with dimensions (e.g., surface area, etc.) configured to minimize or eliminate the buildup of electrostatic energy by the radiation blocking regions and/or the discharge of electrostatic energy from the radiation blocking regions and the damage that may be caused by such electrostatic discharge. The methods may include configuring the reticle to prevent radiation from passing through the cut lines between adjacent sections of a subdivided radiation blocking region.
US08383300B2	Exposure mask with double patterning technology and method for fabricating semiconductor device using the same An exposure mask for forming a G-type active region with a double patterning technology includes a bar shaped first light-blocking pattern to define an I-type active region, and an island shaped second light-blocking pattern to define a bit line contact region. The first light-blocking pattern and the second light-blocking pattern are arranged alternately.
US08383299B2	Double patterning mask set and method of forming thereof A double patterning mask set includes a first mask having a first set of via patterns, and a second mask having a second set of via patterns. The first set of via patterns includes at least two via patterns arranged along a diagonal direction, each of the at least two via patterns has at least a truncated corner. The first set of via patterns and the second set of via patterns are interlacedly arranged along a horizontal direction and a vertical direction.
US08383295B2	Composition for holographic recording medium A composition for holographic recording medium, which can be coated in a uniform thickness and enables to simply produce a high definition holographic recording medium is provided. And a holographic medium having a low error rate, high storage capacity, high-performance, high-density, which is produced using the composition for the holographic recording medium, is also provided. The composition comprises a (meth)acrylic acid ester group-containing polymerizable substance, an alicyclic epoxy group-containing cationical polymerizable substance of which is ring-opening polymerized by heat, and a hydroxyl group-containing substance which is reactive with the alicyclic epoxy group-containing cationical polymerizable substance. The holographic recording medium is produced by forming a holographic recording layer on a substrate by applying the composition on the base material and polymerizing the alicyclic epoxy group-containing cationical polymerizable substance and the hydroxyl group-containing substance.
US08383294B2	Selective hologram formation We propose a method of detecting the presence of certain chemical and biochemical substances by virtue of the fact that they are, or have attached to them, either a dye molecule which acts as a photosensitizer for a holographic recording process, or another essential molecular component of the holographic recording material such as a monomer or a free radical generator. A recording material used in the process utilizes a photopolymer system consisting of a monomer and a crosslinking monomer, a free radical generator, a photosensitizer and, additionally, a polymeric binder when dry formulations are required and specifically lacks the substance to be detected. Subsequent holographic exposure records an interference pattern only where the complementary substance is present. Applications are broad ranging. Examples in diagnostics, printing, security, and environmental monitoring are given.
US08383293B2	Supports for fuel cell catalysts based on transition metal silicides An electrocatalyst for fuel cell applications includes a catalyst support and a noble metal or noble metal-based alloy catalyst supported upon the catalyst support. The catalyst support characteristically includes a Group IV-VI transition metal silicide with or without the mixing of carbon. A fuel cell incorporating the electrocatalyst into the anode and/or cathode is disclosed. Such fuel cell exhibit improved cycling and operating performance.
US08383290B2	Fuel cell assembly A passive fuel cell assembly, in which there is neither air pump, nor fuel pump, is comprised of a plurality of bi-cell units. Each bi-cell unit includes a first cell and a second cell, and each cell includes an electrode of a first polarity and an electrode of a second polarity, with an ion permeable membrane disposed therebetween. The bi-cell unit further includes a fuel container which comprises a housing defining a fuel chamber having a first and second open surface. The first and second cells are disposed on opposite sides so that electrodes of each cell having the first polarity are disposed in fluid contact with the fuel chamber. The assembly further includes an oxidizer supply member disposed between adjacent pairs of bi-cell units. The oxidizer supply member includes an oxidizer chamber having four sides to take in air, and having first and second open surfaces. The oxidizer supply member is disposed so that electrodes of the second polarity of adjacent bi-cell units are in fluid contact with the chamber of the oxidizer supply member. The various bi-cell units may be electrically interconnected in mixed series parallel relationship to obtain long operational life. The fuel cell bi-cell assembly may be configured to operate in conjunction with a liquid fuel such as an alcohol, and using air as an oxidizer.
US08383288B2	Fuel cell separator and molding method for fuel cell separator The present invention provides a resin molding method for fuel cell separator. The fuel cell separator includes: a resin mold region formed inward a predetermined distance from an edge; a through hole formed at the resin mold region; and a front end region formed between the through hole and the edge at the resin mold region. The resin molding method includes: a die set process that the resin mold region of the fuel cell separator is set in the die such that the front end region is held by a pair of anti-deformation pins of the die; and a resin filling process that a resin is filled in the die, wherein the resin is molded on the resin mold region of the fuel cell separator so as to be filled in the through hole, and a resin member is thereby molded on the resin mold region so as to extend outward from the edge.
US08383287B2	Fuel cell electrode catalyst and polymer electrolyte fuel cell using the same This invention provides a fuel cell electrode catalyst in which at least one transition metal element and at least one chalcogen element are supported on a conductive support, wherein the fuel cell electrode catalyst comprises a core portion comprising a transition metal crystal and a shell portion comprising surface atoms of the transition metal crystal particle and chalcogen elements coordinating to the surface atoms, and the outer circumference of the core portion is being partially covered with the shell portion. The fuel cell electrode catalyst has a high level of oxygen reduction performance, high activity as a fuel cell catalyst and comprises a transition metal element and a chalcogen element.
US08383282B2	Contact arrangement and method for assembling a fuel cell stack from at least one contact arrangement The invention relates to a contact arrangement for a fuel cell stack, especially for an SOFC fuel cell stack, comprising an interconnector arrangement which is arranged to establish an electrically conducting connection via at least one contact element on the anode side and at least one such element on the cathode side between an anode of a first membrane electrode assembly and a cathode of a second membrane electrode assembly. The invention is characterized in that at least one component to be sintered is provided on only one side of the interconnector arrangement, on the side of the interconnector arrangement facing the anode or the one facing the cathode, the component being coupled to the first or second membrane electrode assembly in such a manner that the electrically conducting connection can be established via the contact element on the anode side or via that on the cathode side by sintering the component to be sintered. The invention also relates to a method for assembling a fuel cell stack form at least one such contact arrangement. The invention further relates to a fuel cell stack, especially an SOFC fuel cell stack, comprising said contact arrangement, the fuel cell stack preferably being assembled according to the aforementioned method.
US08383281B2	Fuel cell system A fuel cell system has a flooding elimination mode as one of available operation modes of fuel cells and includes a drive controller. When the ambient temperature of the fuel cell system is not higher than a preset first temperature, the drive controller causes the fuel cells to be driven in the flooding elimination mode. When the ambient temperature of the fuel cell system is not lower than a preset second temperature that is higher than the first temperature, the drive controller prohibits the fuel cells from being driven in the flooding elimination mode. On the occasion of input of a checkup instruction of the fuel cells, the drive controller causes the fuel cells to be driven in the flooding elimination mode, independently of the ambient temperature. This arrangement effectively improves the user's convenience at the checkup time of the fuel cell system having the operation mode for eliminating the state of flooding.
US08383280B2	Fuel cell separator plate with integrated heat exchanger A fuel cell separator plate having a planar substrate having a main body with first and second opposed major surfaces, a first open channel reactant flow field recessed in the first major surface, and a first segment extending from the main body, and a thermally and electrically conductive first current collector layer having a flow field portion on the first major surface of the main body and a heat exchange portion extending from the flow field portion onto the first segment such that heat in the flow field portion conducts to the heat exchange portion during fuel cell use.
US08383279B2	Fuel cell system and method for calculating circulation ratio in the same There are disclosed a fuel cell system capable of inhibiting freezing at a joining part of a supply gas and a circulation gas during a system operation, and a method for calculating circulation ratio in the system. In the fuel cell system of the present invention, the circulation gas discharged from a fuel cell meets the supply gas from a gas supply source to be supplied to the fuel cell, and a flow rate of the circulation gas with respect to that of the supply gas is set in consideration of condensation latent heat of water vapor in the circulation gas. The flow rate of the circulation gas with respect to that of the supply gas can be set by heat balance calculation at the joining part in consideration of the condensation latent heat.
US08383276B2	High voltage electrolyte An organic electrolyte solvent includes a compound of the formula: R1—SO2—NR2—OR3 wherein R1 is selected from alkanes, alkenes, alkynes, aryls and their substituted derivatives and perfluorinated analogues; R2 is selected from alkanes, alkenes, alkynes, aryls and their substituted derivatives; R3 is selected from alkanes, alkenes, alkynes, aryls and their substituted derivatives wherein the electrolyte solvent is stable at voltages of greater than 4.0 volts.
US08383272B2	Anode current collector, anode, and secondary battery A secondary battery that has superior safety and is able to provide more favorable cycle characteristics is provided. A laminated body in which a cathode and an anode are layered with a separator impregnated with an electrolytic solution in between is contained in a package can and a package cup. In the anode, an anode active material layer containing an anode active material such as silicon is provided on an anode current collector in which projection sections are formed on a base material. The base material contains carbon and sulfur respectively having a content ratio of 100 ppm or less, and contains crystallites having an average diameter of from 0.01 μm to 5 μm both inclusive.
US08383271B2	Electrode and method for manufacturing the same An electrode 30 (such as a positive electrode for a lithium ion battery) is provided in which an active material layer (35), having an electrode active material as a main component thereof, is held by a metallic power collector (32). A barrier layer (33) containing a non-water-soluble polymeric material (334) and a conductive material (332) is provided on the surface of the power collector (32). An interconnecting layer (34), having higher electrical conductivity than the barrier layer (33) and containing a polymeric material (344) and a conductive material (342), is interposed between the barrier layer (33) and the active material layer (35).
US08383268B2	Lithium ion secondary battery and a method for manufacturing the same A lithium ion secondary battery includes a positive electrode, a negative electrode and a thin film solid electrolyte including lithium ion conductive inorganic substance. The thin film solid electrolyte has thickness of 20 μm or below and is formed directly on an electrode material or materials for the positive electrode and/or the negative electrode. The thin film solid electrolyte has lithium ion conductivity of 10−5Scm−1 or over and contains lithium ion conductive inorganic substance powder in an amount of 40 weight % or over in a polymer medium. The average particle diameter of the inorganic substance powder is 0.5 μm or below. According to a method for manufacturing the lithium ion secondary battery, the thin film solid electrolyte is formed by coating the lithium ion conductive inorganic substance directly on the electrode material or materials for the positive electrode and/or the negative electrode.
US08383267B2	Anode and secondary battery including the same A secondary battery having high cycle characteristics is provided. The secondary battery includes a cathode, an anode, and an electrolyte. In the anode, an anode active material layer containing silicon, carbon, and oxygen as an anode active material is provided on an anode current collector. In the anode active material, a content of carbon is from 0.2 atomic % to 10 atomic % both inclusive, and a content of oxygen is from 0.5 atomic % to 40 atomic % both inclusive. A ratio from 0.1% to 17.29% both inclusive of the silicon contained in the anode active material exists as Si—C bond.
US08383262B2	Stacking-type secondary battery providing two or more operation voltages The present invention relates to a lithium secondary battery comprising a battery cell formed by stacking a plurality of full cells having a structure of cathode/separator/anode or bicells having a structure of cathode(anode)/separator/anode(cathode)/separator/cathode (anode), as a unit electrode assembly, wherein (i) a cathode active material or (ii) an anode active material or (iii) a cathode active material and an anode active material in two or more unit electrode assemblies are configured to have a different composition to induce a voltage difference and separate electrode terminals are installed in a battery case according to the voltage difference to thereby simultaneously provide two or more voltages by a single battery.
US08383258B2	Cap assembly of improved safety and cylindrical secondary battery employed with the same Disclosed herein is a cap assembly loaded on an open upper end of a cylindrical container of a battery in which an electrode assembly is mounted in the cylindrical container, the cap assembly including a safety vent having a predetermined notch configured to rupture by high-pressure gas generated in the battery, a current interruptive device coupled to a bottom of the safety vent by welding for interrupting current when internal pressure of the battery increases, and a current interruptive device gasket for surrounding an outer circumference of the current interruptive device, wherein the current interruptive device includes two or more through holes for gas discharge, the through holes being formed such that the sum of areas of the through holes is equal to 20% to 50% of an entire area of the current interruptive device. When high-pressure gas is generated in the battery, the cap assembly effectively interrupts current and rapidly discharges the gas, thereby greatly improving safety of the battery.
US08383257B2	Electrochemical storage cell with blow out vents An electrochemical storage cell is disclosed which includes at least one cathode sheet, at least one anode sheet and at least one separator sheet combined to make a core. The core is housed within a rectangular shell with four sides and two ends, sealed with an air-tight seal. The cell further includes a blow out vent in at least one of the two ends of the shell. This blow out vent is adapted to open and release excess pressure above a predetermined level to thereby prevent catastrophic rupture of the shell.
US08383256B1	MEMS safety valve for batteries A battery has a battery case with a hole, and a micro-electro-mechanical system (MEMS) safety valve mounted to the battery case over the hole. The MEMS safety valve includes a silicon diaphragm and a silicon electrode layer with a movable electrode mounted above the diaphragm, a stationary electrode around the movable electrode, and one or more links electrically connecting the movable and the stationary electrodes. The stationary electrode, the links, and the movable electrode form part of an electrical path between one or more battery cells and a battery terminal. The links break to open the electrical path when the pressure in the battery case pushes the diaphragm and the links past a first limit. The diaphragm breaks to release fluid from the battery case when the pressure pushes the diaphragm past a second limit. The first limit may be smaller, larger, or the same as the second limit.
US08383254B2	Method of producing self-assembled cubic FePt nanoparticles and apparatus using same An apparatus includes a substrate, a magnetically soft underlayer on the substrate, and a plurality of generally cubic FePt nanoparticles on the magnetically soft underlayer, wherein the nanoparticles have a magnetization in a direction substantially normal to a surface of the magnetically soft underlayer. The FePt nanoparticles can have magnetically easy axes perpendicular to the surface of the soft underlayer.
US08383252B2	Rare earth magnet and its production method The present invention has aimed to provide a method which is capable of producing a rare earth magnet having a protective layer that can provide a sufficient water resistance. The present invention provides a method for producing a rare earth magnet comprising a magnet body containing a rare earth element and a protective layer with high water resistance formed on the surface of the magnet body, the method comprising a first step in which a zinc compound soluble in an alkaline solution is dissolved in an alkali silicate solution to prepare a treatment solution, a second step in which the treatment solution is attached on the surface of the magnet body, and a third step in which the treatment solution attached on the magnet body surface is cured to form a protective layer comprising the cured product of the treatment solution.
US08383246B2	Polypropylene-based shrink films In one aspect is provided a film, a shrink sleeve film in a particular embodiment, comprising at least one core layer, one skin layer, and optionally one tie layer between the two, wherein the core comprises from 0 to 30 wt % polypropylene by weight of the core layer, and from 70 to 100 wt % of a random propylene-α-olefin copolymer having within the range of from 1 to 10 wt % α-olefins, the α-olefin selected from the group consisting of ethylene and C4 to C12 α-olefins, and having an MWD within the range of from 1.2 to 4.5 and a melting point within the range of from 110 to 150° C.; wherein the film possesses a TD Tensile Strength of from 100 to 400 MPa and a MD Tensile Strength of from 20 to 60 MPa. In a particular embodiment, the at least one skin layer comprises a solvent sealable material.
US08383238B2	Highly porous coated fine particles, composition, and method of production Fine particles of a highly porous, low density material in which the pore chambers have been at least partially evacuated and refilled with a gas having a low thermal conductivity, and the obtained particles are encapsulated with a protective, durable coating. The particles are particularly useful as durable thermal insulating material.
US08383231B2	Sandwich panel A sandwich panel includes a middle material (2) and a surface material (3) that are laminated with a hollow columnar core (1). The middle material (2) is composed of a set of unidirectional fiber bodies (4, 5) each of whose fibers are aligned in one direction, and bonding layers formed by woven fiber bodies (6, 7). The woven fiber body (7) includes a warp yarn and a woof yarn that is orthogonal to the warp yarn, and the yarns are woven, and the woven fiber body (7) is formed so that any one of the warp yarn and the woof yarn is substantially parallel to the edge of the sandwich panel, and the other of the warp yarn and the woof yarn is substantially orthogonal to the edge of the sandwich panel.
US08383225B2	Vacuum-insulation element A vacuum insulation element, which consists of a multi-layer configuration of at least two molded plates, that can be subjected to a vacuum, wherein the molded plates in each case have a surrounding edge region which in each case form a sealing surface, wherein the sealing surfaces of the molded plates are hermetically bonded together in the assembled state thus forming a sealing frame, such that a cavity between the, at least two, molded plates is sealed in a manner that is vacuum-tight, and the structure of the, at least two, molded plates distributes the atmospheric pressure which is applied to the multi-layer configuration when subjected to a vacuum such that the specified structure remains stable, wherein the molded plates have numerous molded structural elements in the shape of projections and depressions which face in opposite directions from the molded plates and the projections, or respectively, depressions which face the other plate respectively rest against each other thereby forming a grid of support points when subjected to a vacuum, and the projections, or respectively, depressions which face away from the other plate respectively form numerous cavity cells which can be subjected to a vacuum between the support points, wherein the cavity cells are connected in such a manner that they communicate with one another, and as a whole, form the cavity.
US08383218B2	Multilayer composite in form of extruded hollow sections Multi-layer composites, particularly thermoplastic composites, in form of an extruded hollow section, e.g. tubes or hoses for liquid fuel lines, include a thermoplastic outer layer and at least one further layer, whereinthe outer layer is formed by a mixture based on (A) 80 to 20 parts by weight of at least one polyamide (PA) and (B) 20 to 80 parts by weight of at least one polyamide elastomer (TPE-A), of polyether amides, polyester amides, polyether ester amides, polyether ester ether amides or mixtures thereof, wherein the sum of (A) and (B) is 100 parts by weight, the hollow section being produced at extrusion speeds, of over 20 m/min, so that the produced hollow section has an elongation at break, of over 200%, wherein the elongation at break has been measured at the finished hollow section according to DIN EN ISO 527-2.
US08383217B2	Corrosion inhibiting protective sleeves A corrosion inhibiting protective sleeve formed of a woven fabric material and impregnated with a vapor-phase corrosion inhibitor (VpCI).
US08383215B2	Container for products containing aromatic compounds A container is provided for substances that contain an antibacterial compound. The container has a tube body and a tube shoulder. The tube shoulder is made of an alkene based polymer such as a polyethylene or a polypropylene. Such alkene based polymers have a high absorptivity for antibacterial compounds such as triclosan. The shoulder includes a barrier unit. The barrier unit is made of a polymeric material such as polytrimethylene naphthalate, polyethylene naphthalate and acrolonitrile/methacrylate. This barrier unit can be a film on the tube shoulder or a co-injection molded insert in the shoulder. The absorption is less than 10 mg/dm2.
US08383213B1	Decoration device for windshield wipers A decoration device for attaching to a windshield wiper featuring a generally flexible elongated strip; a cloth component disposed on a top surface of the strip, the cloth component resembles a tail of an animal, the animal includes a cat, a dog, a lion, a rhinoceros, a snake, a tiger, an elephant, a zebra, a wolf, a dingo, a kangaroo, or the like; and at least one clip disposed on a bottom surface of the strip, the clip is configured to wrap around a portion of the arm of the windshield wiper, the clip comprises a screw clamp for tightening the clip around the portion of the arm of the windshield wiper.
US08383212B2	Alignment film and method of manufacturing the same, phase difference device and method of manufacturing the same, and display unit An alignment film or a phase difference device with small shift from a desired alignment direction and a display unit including the same are provided. The alignment film includes: a substrate having a plurality of grooves extending in a specific direction on a surface; and a non-alignment thin film formed along a surface of the plurality of grooves. The phase difference device includes: an alignment film that has a substrate having a plurality of grooves extending in a specific direction on a surface and a non-alignment thin film formed along a surface of the plurality of grooves; and a phase difference layer that is provided being contacted with a surface of the non-alignment thin film, and includes a liquid crystal material that is aligned along an extending direction of a dent formed by the non-alignment thin film and is polymerized.
US08383211B2	Method of forming thin film A method of forming a thin film includes: forming a thin film on a substrate by discharging liquid material as a droplet; discharging the liquid material to a liquid material disposing-region that is wider than a thin film forming region; and drying the liquid material thereby to dispose a raising portion at the edge of the thin film in the outside of the thin film forming region.
US08383210B2	Method of forming a film by deposition from a plasma A method is described of depositing film of an amorphous or microcrystalline material, for example silicon, from a plasma on to a substrate. Microwave energy is introduced into a chamber as a sequence of discrete microwave pulses, a film precursors gas is introduced into the chamber as a sequence of discrete gas pulses, and gas for generating atomic hydrogen is supplied to the chamber at least during each microwave pulse. Each microwave pulse is followed in non-overlapping fashion with a precursor gas pulse, and each precursor gas pulse is followed by a period during which there is neither a microwave pulse nor a precursor gas pulse.
US08383207B2	Configurable application of a tire dressing A tire dressing system includes an imaging device that captures an image of a vehicle tire or portion thereof and at least one application device that applies tire dressing to the tire based on the captured image. The system determines one or more tire parameters based on the captured image. The tire dressing system configures the at least one application device based on the tire parameter(s) such that the application device substantially restricts application of tire dressing to within the boundaries of the tire sidewalls. By determining the tire parameters, the tire dressing system may apply the tire dressing to the tire sidewalls while reducing or minimizing application of tire dressing to the body or rims of the vehicle.
US08383206B2	Surface treating method for making a housing A surface treating method for making a housing have a metallic main body includes the follow steps. A primer is coated on the metallic main body to form a bottom layer. A plating layer is formed on the bottom layer. An adhesive is coated on the plating layer to form an adhesive layer. Finally, a lacquer is coated on the adhesive layer to form an outer layer.
US08383205B2	Methods for treating textiles with an antimicrobial composition In one embodiment, a method for treating a textile with an antimicrobial composition includes preparing an antimicrobial composition that includes water, an organic acid, chitosan, and one or more heterocyclic N-halamine compounds, preparing an aqueous solution that comprises the antimicrobial composition, applying the aqueous solution to a textile, and heating the textile to cure the antimicrobial composition.
US08383202B2	Method and apparatus for load-locked printing The disclosure relates to a method and apparatus for preventing oxidation or contamination during a circuit printing operation. The circuit printing operation can be directed to OLED-type printing. In an exemplary embodiment, the printing process is conducted at a load-locked printer housing having one or more of chambers. Each chamber is partitioned from the other chambers by physical gates or fluidic curtains. A controller coordinates transportation of a substrate through the system and purges the system by timely opening appropriate gates. The controller may also control the printing operation by energizing the print-head at a time when the substrate is positioned substantially thereunder.
US08383199B2	Process for lining the interior surface of a metal pipe for conveying oil The present invention relates to a process for adhering a lining to the interior surface of an oil pipe wherein the lining imparts substantially reduced adhesion of asphaltenes, paraffin wax, and inorganic scale, so as to reduce plugging of the oil pipe, and impermeability to salt water so as to protect the oil pipe from corrosion.
US08383197B2	Titanium carbide or tungsten carbide with combustion synthesis to block porosity in C-C brake discs for antioxidation protection A metal powder is applied to the surface of the area of a carbon-carbon composite brake disc to be protected against migration of antioxidant. The metal powder may be titanium powder or tungsten powder. A chemical reaction between the metal powder and carbon is then initiated by heating the powder-coated brake to the ignition temperature via application of electric current (Joule preheating) or by heating it in a furnace. Upon combustion, the metal particles react with carbon in the composite, forming liquid carbide that flows into pores of the composite brake disc to be protected.
US08383194B2	Film forming apparatus, film forming system, film forming method, and method of manufacturing electronic device or organic electroluminescence element To provide a film forming apparatus capable of using an expensive organic EL raw material without waste and uniformly forming an organic EL film over a long period of time and a jig therefor.A plurality of ejection vessels are provided for a single raw material container section. A switcher is provided for carrying out switching from a piping system, which evaporates an organic EL raw material in the raw material container section and supplies it along with a carrier gas to one of the ejection vessels, to a piping system for another ejection vessel. In this manner, by supplying the organic EL raw material from the single raw material container section to the plurality of ejection vessels by switching, the use efficiency of the organic EL raw material can be improved.
US08383191B2	Color filter substrate and fabricating method thereof A color filter substrate includes a substrate, a black matrix that defines cell areas on a substrate and prevents light leakage, a color filter formed in the cell areas defined by the black matrix, and a conductive thin film formed on the rear surface of the substrate for preventing the generation of static electricity, wherein the conductive thin film is formed of a photo-resist containing a conductive material.
US08383185B2	Shelf stable homogeneous suspension Protein-containing suspensions such as milk that are preserved by a UHT treatment, show age gelation. This age gelation can be reduced by inclusion of an emulsifier with an HLB value below 16.
US08383183B2	Sweetness enhancers, sweetness enhanced sweetener compositions, methods for their formulation, and uses The present invention relates generally to sweetness enhancers capable of enhancing the sweet taste of sweetener compositions and the sweetener compositions produced therefrom. In particular, the present invention relates to sweetener compositions comprising sulfamates capable of enhancing the sweetness of the sweetener composition.
US08383175B2	Active ingredient delivery system with an amorphous metal salt as carrier An active ingredient delivery system and a method of making or using the same, wherein the delivery system includes an active ingredient and a carrier component of an amorphous metal salt, with the active ingredient at least partly fixed to and partly encapsulated by the carrier component. The active ingredient may be a bitter tasting polyphenol such as a flavonoid.
US08383167B2	Method for cosmetically treating caspase-14 deficiency A method of cosmetic care comprising activating capsase-14 expression in skin deficient in caspase-14 expression by applying, on at least one skin zone in need thereof, an effective amount of a plant extract selected from the group consisting of litchi, glasswort, peach, soja seed, sweet basil, cucumber, chanterelle, leek, kiwi fruit, rhubarb, grapefruit, wheat, raspberry, plum, and mixtures thereof, to activate caspase-14 expression in said skin.
US08383164B2	Antiviral composition and method for using the same The present invention provides an antiviral composition and system for using the same, wherein the antiviral composition includes between about 0.1 to about 0.3 wt % of antimicrobial agent such as benzalkoniumchloride, between about 0.1 to about 1 wt % of chlorinated phenol compound, such as parachlorometaxylenol, between about 0.1 to about 3 wt % of hydrogen peroxide, and at least about 60 wt % aqueous solvent.
US08383161B2	Radioopaque covalently crosslinked hydrogel particle implants A pharmaceutically acceptable implant system comprising a collection of pharmaceutically acceptable, covalently-crosslinked hydrogel particles having a radioopaque agent covalently attached to a plurality of the particles in the collection, with the radioopaque agent being present in the collection at a concentration of at least about 0.1% w/w. The implantable materials may be used, for instance, in an iatrogenic site and for fiducial marking.
US08383160B2	Compositions comprising solid particles entrapped in collapsed polymeric microspheres, and methods of making the same The present invention relates to method for modifying or treating solid particles which includes the steps of: (a) forming a gelled mixture by mixing either simultaneously or sequentially in any order: (1) hollow microspheres each comprising a deformable polymeric shell having entrapped therein an expandable fluid, (2) a polar organic solvent capable of swelling but not dissolving the polymeric shells of the hollow microspheres, and (3) solid particles, wherein micro-channels are formed in the swelled polymer shells to allow entry of the solid particles into the hollow microspheres and exit of the expandable fluid therefrom, thereby forming microspheres that each comprises a collapsed polymeric shell in a gelled state and has one or more of said solid particles entrapped therein; (b) removing the expandable fluid and the polar organic solvent from the gelled mixture; and (c) coating the microspheres thus-produced with a film-forming material to form a liquid-impermeable membrane thereon.
US08383156B2	Coating for a medical device having an anti-thrombotic conjugate Methods for making comb-type antithrombotic conjugate wherein substantially all side chains of water soluble poly(vinyl alcohol) (PVA) are extended by ring-opening polymerization to form a copolymer wherein substantially all terminals are conjugated to an antithrombotic molecule. In addition, a method is provided for applying a coating comprising a comb-type anti-thrombotic conjugate to at least a portion of an implantable device to prevent or reduce the formation of thrombosis on the surface of the device. A first or sub-layer of the coating is prepared by mixing a polymeric material and a biologically active agent with a solvent, thereby forming a homogeneous solution. A second or outer layer comprising a comb-type anti-thrombotic conjugate may be applied over the inner drug-containing layers using, for example, a dip coating or spray coating process. Alternatively the comb-type antithrombotic conjugate may be used as a matrix material to encapsulate a pharmaceutical agent to form microspheres or nanospheres before depositing the microspheres or nanospheres onto a medical device.
US08383152B2	Pharmaceutical dosage form The invention relates to a pharmaceutical dosage form, preferably with controlled release of a pharmacologically active compound (A) contained therein, the pharmaceutical dosage form very preferably being tamper-resistant and most preferably having a breaking strength B1 of at least 500 N in direction of extension E1 and having a breaking strength B2 of less than 500 N in direction of extension E2.
US08383151B2	Pharmaceutical compositions of rifaximin A pharmaceutical composition comprising therapeutically effective amount of rifaximin or pharmaceutically acceptable salt or enantiomer or polymorph thereof, pharmaceutically acceptable excipient(s) and release controlling agent(s). Pharmaceutical composition of rifaximin comprising: at least two entities wherein one entity is an immediate release or fast release and the other is controlled release. The pharmaceutical composition in the form of multilayer tablet comprising, at least one layer comprising, therapeutically effective amount of rifaximin or pharmaceutically acceptable salt or enantiomer or polymorph thereof, pharmaceutically acceptable excipient(s); said layer providing controlled release rifaximin; and at least one layer which provides increased residence time of the dosage form in the gastrointestinal tract. The pharmaceutical formulation comprising rifaximin having an in vitro dissolution profile, wherein about 70% of rifaximin is released in about 24 hours. The composition comprising therapeutically effective amount of rifaximin or pharmaceutically acceptable salt(s) or enantiomer(s) or polymorph(s) thereof, one or more release controlling agent(s) and pharmaceutically acceptable excipient(s) causing pathogenic eradication.
US08383149B2	High enhancer-loading polyacrylate formulation for transdermal applications A polyacrylate formulation suitable for delivery of drug through a body surface of an individual. By loading the drug and permeation enhancers at a high concentration into a polyacrylate proadhesive that has inadequate adhesive properties for typical adhesive application on the skin, a formulation with desirable adhesive characteristics and effective therapeutic properties can be made. The proadhesive has higher glass transition temperature than typical pressure sensitive adhesives.
US08383145B2	Film-form preparation An object of the present invention is to provide a film-form preparation to be used in desensitization therapy and a method for producing the same. This film-form preparation enables the patient to self-administer an allergen and adjust the dose, has excellent portability, has no residual sensation, provides excellent protection against accidental swallowing, is easy for a caregiver to administer, and can greatly improve the QOL of both patients and caregivers. Additionally, this film-form preparation enables arbitrary control of the dissolution time in the mouth, particularly sublingually and has very little gummy sensation in the mouth and better feeling when touched by the fingers. A film-form preparation including: an allergen; an edible polymer that is soluble in both water and a polar organic solvent; and one or two or more types of particles selected from the group consisting of monosaccharide to hexasaccharide sugars and sugar alcohols thereof that have an average particle size of 0.1 to 100 μm.
US08383143B2	Antimicrobial medical devices containing chlorhexidine free base and salt The present disclosure invention relates to medical devices treated with a solution comprising one or more solvents and a combination of chlorhexidine free base and a water-soluble chlorhexidine salt in a weight/weight ratio of between about 1:1 to about 1:5, preferably about 1:1.
US08383142B2	Implantable devices comprising cyanoacrylate primer coatings Coatings for implantable devices or endoluminal prosthesis, such as stents, are provided, including a method of forming the coatings. The coatings can be used for the delivery of an active ingredient or a combination of active ingredients.
US08383141B2	Dry hemostatic compositions and methods for their preparation Dry cross-linked gelatin compositions are prepared that rapidly re-hydrate to produce gelatin hydrogels suitable as hemostatic sealants. Gelatin is cross-linked in the presence of certain re-hydration aids, such as polyethylene glycol, polyvinylprovidone, and dextran, in order to produce a dry cross-linked gelatin powder. The use of the re-hydration aids has been found to substantially increase the re-hydration rate in the presence of an aqueous re-hydration medium, typically thrombin-containing saline.
US08383135B2	Solid dosage form that promotes reliable oral, esophageal and GI transit A solid dosage form designed to facilitate rapid and reliable oral, esophageal and GI transit has a surface area of the contact patch, i.e., the area of contact between the dosage form and the bodily surface reduced. The dosage form can be an asymmetric oral dosage unit containing a bioactive, the dosage unit being asymmetric with respect to a rotational axis perpendicular to a longitudinal axis of the dosage form, the rotational axis being located substantially at a mid point along the longitudinal axis. The dosage unit may have an outer surface ridged or dimpled or have at least one annular ring so as to reduce the contact patch of the dosage unit with a flat surface compared to non-ridged dosage unit of the same size and shape. The oral dosage unit can also have a spherical shape with or without ridges and/or dimples. Dies for forming these oral dosage units have, in a closed state, a cavity having a shape corresponding to the oral dosage unit.
US08383133B2	Conjugates of Plasmodium falciparum surface proteins as malaria vaccines Conjugates of ookinete surface protein Pfs25 are provided that are efficacious as vaccines against Plasmodium falciparum, the most severe form of malaria. Conjugates of ookinete surface protein Pvs25 for use as a vaccine against Plasmodium vivax are also provided. Methods for preparing the conjugates, which comprise the ookinete surface protein bound onto itself or onto another protein by a linking group, are also provided.
US08383132B2	Immunostimulatory recombinant intracellular pathogen immunogenic compositions and methods of use Immunogenic compositions comprising recombinant intracellular pathogens that have been transformed to express recombinant immunogenic antigens of the same or other intracellular pathogens and immunostimulatory molecules are provided. Exemplary immunogenic compositions include, but are not limited to, recombinant BCG expressing Mycobacteria major extracellular proteins and immunostimulatory molecules.
US08383129B2	Employment of rotavirus proteins, derived proteins and peptides for the modulation of tissue permeability The present invention refers to the use of rotavirus proteins VP4, VP8 and their derived fusion proteins and peptides, for enhancing the delivery of pharmaceutical agents through the paracellular pathway. These rotavirus proteins and derived peptides may additionally be employed to reduce unwanted cellular adhesion that can occur between cancerous cells, or between normal cells as a result of surgery, injury, chemotherapy, disease, inflammation or other pathological conditions.
US08383126B2	Bacterial pheromones and uses thereof RP-factors, their cognate receptors, convertases, respective genes and inhibitors or mimetics thereof are described. In particular, antibodies, pharmaceutical compositions and (therapeutic, diagnostic) methods based on the RP-factors and their receptors/convertases are described.
US08383119B2	Biological substance nesfatin and its related substances and uses thereof The present invention relates to a novel method of obtaining a factor involved in appetite control and/or body weight control, as well as genes obtained by said method, polypeptides encoded by said genes, or novel polypeptides obtained from the information on polypeptides encoded by said genes as a means for treating, controlling or diagnosing diseases associated with eating disorders and/or body weight control. Also the present invention relates to substances that inhibit the effects of said genes or said polypeptides as a means for treating, controlling or diagnosing diseases associated with appetite control and/or body weight control. By using thiazolidine diones having a PPAR γ agonist activity, genes and polypeptides involved in appetite regulation and/or body weight reduction can be obtained. NESFATIN or the like obtained by said method can be used as a means for treating, controlling or diagnosing diseases associated with eating disorders and/or body weight control.
US08383115B2	Engineered scFv against bovine herpes virus type I The present disclosure describes a single chain variable fragment (scFv) that binds BHV-1 virus comprising a light chain variable region, a linker and a heavy chain variable region. The disclosure also describes nucleic acid molecules encoding the scFv molecules, methods and uses thereof for treating or neutralizing BHV-1 infection and diagnostic methods, agents and kits thereof.
US08383113B2	Anti-ADDL antibodies and uses thereof The present invention relates to antibodies that differentially recognize multi-dimensional conformations of Aβ-derived diffusible ligands, also known as ADDLs. The antibodies of the invention can distinguish between Alzheimer's Disease and control human brain extracts and are useful in methods of detecting ADDLs and diagnosing Alzheimer's Disease. The present antibodies also block binding of ADDLs to neurons, assembly of ADDLS, and tau phosphorylation and are there useful in methods for the preventing and treating diseases associated with soluble oligomers of amyloid β 1-42.
US08383107B2	Single domain brain-targeting antibody fragments derived from llama antibodies A phage-displayed library of llama single heavy domain antibodies (sdAbs) was enriched for species that selectively bind to and are internalized by human cerebromicrovascular endothelial cells (HCEC). From the enriched library, two sdAbs were selected, sequenced, subcloned, and expressed as fusion proteins with c-myc-His5 tags (His5 is SEQ ID NO:101). Similarly as phage-displayed sdAbs, these soluble tagged sdAbs were shown to selectively bind to HCEC and to transmigrate across in vitro human blood-brain barrier (BBB) model. In contrast to an unrelated llama sdAb, these sdAbs were also detected in the brain after i.v. injection into mice. These small (˜13 kDa) antibody fragments have essential characteristics of brain-specific delivery vectors and can be used to facilitate drug transport across the BBB.
US08383102B2	Fusion of peptidoglycan hydrolase enzymes to a protein transduction domain allows eradication of both extracellular and intracellular gram positive pathogens Lysostaphin is a bacteriocin secreted by S. simulans to kill S. aureus, and has been shown to also be a potent antimicrobial for many antibiotic-resistant strains of S. aureus. By adding a ˜13 amino acid protein transduction domain (PTD) from the HIV-TAT protein to lysostaphin to form lysostaphin-PTD, both extracellular and intracellular forms of S. aureus and MRSA are killed in all (multiple) cell types examined.
US08383100B2	Method to treat and prevent skin diseases with Porifera-based therapeutic compositions treating and preventing skin diseases Methods to treat skin conditions and diseases by applying Porifera based compositions to the skin are described. Treatable skin conditions and diseases include acne vulgaris, rosacea, seborrheic dermatitis, atopic dermatitis, psoriasis, photo-aging, actinic keratosis and eczema, also known as atopic dermatitis. Therapeutic compositions are obtained from members of Porifera, for example sponges, specifically, fresh water sponges. An example of a fresh water sponge is Spongilla species. One specific therapeutic composition is obtained from Spongilla species and formulated with pharmaceutical excipients.
US08383097B2	Bacteria cultures and compositions comprising bacteria cultures The present invention relates to bacteria cultures and composition comprising one or more cultures of the invention. The invention also relates to methods of washing or cleaning laundry or fabrics and surfaces as well as degrading waste material using a bacteria culture of the invention.
US08383096B2	Cancer immunotherapy with a viral antigen-defined, immunomodulator-secreting cell vaccine A human cell line, which lacks major histocompatibility class I (MHC-I) antigens and major histocompatibility class II (MHC-II) antigens and which has been modified to comprise and express (i) a nucleotide sequence encoding an immunomodulator and (ii) a nucleotide sequence encoding a viral antigen, and a method of inducing or stimulating an immune response in a human to a viral-associated disease or cancer comprising administering to the human (i) the aforementioned human cell line in an amount sufficient to induce or stimulate an immune response to the viral associated disease or cancer, (ii) a human cell line, which lacks MHC-I and MHC-11 antigens and which has been modified to comprise and express a nucleotide sequence encoding an immunomodulator, and a human cell line, which lacks MHC-I and MHC-II antigens and which has been modified to comprise and express a nucleotide sequence encoding an antigen of EBV, simultaneously or sequentially in either order, by the same or different routes, in amounts sufficient to induce or stimulate an immune response to the viral-associated disease or cancer, or (iii) an immunomodulator and a human cell line, which lacks MHC-I and MHC-II antigens and which has been modified to comprise and express a nucleotide sequence encoding an antigen of EBV, simultaneously or sequentially in either order, by the same or different routes, in amounts sufficient to induce or stimulate an immune response to the viral associated disease or cancer.
US08383095B2	Methods and compositions for enhancing engraftment of hematopoietic stem cells The present disclosure relates to the field of hematopoietic stem cell transplantation. More specifically, methods, compositions and kits for improving engraftment of stem cell transplants by administering myeloid progenitor cells are provided.
US08383094B2	Hepatitis C virus inhibitors The present disclosure relates to compounds, compositions and methods for the treatment of hepatitis C virus (HCV) infection. Also disclosed are pharmaceutical compositions containing such compounds and methods for using these compounds in the treatment of HCV infection.
US08383089B2	Use of IMP3 as a prognostic marker for cancer Provided herein are methods and compositions for the prognostic evaluation of a patient suspected of having, or having, cancer by assessing the expression of IMP3 in a biological sample of a patient. Methods can be used at the time of initial diagnosis of malignant tumors to identify a group of patients with a high potential to develop progression or metastasis later. Therefore, methods not only are able to provide very useful prognostic information for patients but also can help clinicians to select a candidate patient likely to benefit from early and aggressive cancer therapy. Methods and compositions for the treatment of cancer associated with expression of IMP3 are also provided.
US08383085B2	Methods of making iron-containing nanoparticles A method of making iron-containing nanoparticles (e.g., magnetite nanoparticles) that includes contacting an iron-containing precursor with a reducing agent at a temperature less than 200° C. and allowing the mixture to react to form magnetite nanoparticles.
US08383083B2	Polymer precursors of radiolabeled compounds, and methods of making and using the same One aspect of the present invention relates to novel compounds that can be used to prepare radiolabeled compounds in an effective manner. A second aspect of the present invention relates to a method of synthesizing radiolabeled compounds.
US08383082B1	Pharmaceutical composition of nanoparticles The invention discloses a pharmaceutical composition of bioactive nanoparticles composed of chitosan, poly-glutamic acid, and a bioactive agent for oral delivery. The chitosan-based nanoparticles are characterized with a positive surface charge and enhanced permeability for oral drug delivery.
US08383080B2	Treatment of CHA-type molecular sieves and their use in the conversion of oxygenates to olefins A method is disclosed of treating a crystalline material comprising a CHA framework-type molecular sieve, wherein said crystalline material has a composition and involving the molar relationship: (n)X2O3:YO2, where X is a trivalent element, Y is a tetravalent element, and n is less than 0.07, and wherein the crystalline material does not comprise a silicoaluminophosphate, is substantially free of framework phosphorus, or both. The method can comprise treating the crystalline material with steam under conditions such that the prime olefin selectivity of the treated material in an oxygenate conversion process is greater than the prime olefin selectivity of the untreated material in the same process.
US08383078B2	Process and apparatus for the production of synthesis gas Reactive diluent fluid (22) is introduced into a stream of synthesis gas (or “syngas”) produced in a heat-generating unit such as a partial oxidation (“POX”) reactor (12) to cool the syngas and form a mixture of cooled syngas and reactive diluent fluid. Carbon dioxide and/or carbon components and/or hydrogen in the mixture of cooled syngas and reactive diluent fluid is reacted (26) with at least a portion of the reactive diluent fluid in the mixture to produce carbon monoxide-enriched and/or solid carbon depleted syngas which is fed into a secondary reformer unit (30) such as an enhanced heat transfer reformer in a heat exchange reformer process. An advantage of the invention is that problems with the mechanical integrity of the secondary unit arising from the high temperature of the syngas from the heat-generating unit are avoided.
US08383077B2	Surface stabilized electrodes for lithium batteries A method of stabilizing a metal oxide or lithium-metal-oxide electrode comprises contacting a surface of the electrode, prior to cell assembly, with an aqueous or a non-aqueous acid solution having a pH greater than 4 but less than 7 and containing a stabilizing salt, for a time and at a temperature sufficient to etch the surface of the electrode and introduce stabilizing anions and cations from the salt into said surface. The structure of the bulk of the electrode remains unchanged during the acid treatment. The stabilizing salt comprises fluoride and at least one cationic material selected from the group consisting of ammonium, phosphorus, titanium, silicon, zirconium, aluminum, and boron.
US08383065B2	Test module with integral photosensor for electrochemiluminescent detection of hybridization A test module for detecting target nucleic acid sequences in a fluid, the test module having an outer casing having a receptacle for receiving the fluid containing the target nucleic acid sequences, electrochemiluminescent (ECL) probes having an ECL luminophore for emitting photons when in an excited state and a functional moiety for quenching photon emission from the ECL luminophore by resonant energy transfer, electrodes for receiving an electrical pulse to excite the ECL luminophores, and, a detection photosensor for exposure to the photons emitted by the ECL luminophores.
US08383064B2	Genetic test module with low oligonucleotide probe mass and reagent volumes A test module for performing a genetic diagnostic assay, the test module having an outer casing dimensioned for hand-held portability, the outer casing having a receptacle for a biological sample containing target nucleic acid sequences, an array of chambers containing probes for hybridization with the target nucleic acid sequences to form probe-target hybrids, a flow-path extending from the inlet to the probes, and, a reagent reservoir containing a reagent for addition to the sample in the flow-path upstream of the probes, wherein, each of the chambers contains less than 270 picograms of probe and the reagent reservoir has a volume less than 1000,000,000 cubic microns.
US08383062B2	Fluid processing device including size-changing barrier A diagnostic device is provided that includes a plurality of retainment regions interconnected through at least one fluid processing passageway or separated by at least one barrier. A fluid flow modulator can be provided in the fluid processing passageway if a fluid processing passageway is provided. The barrier and/or fluid flow modulator can comprise a polysaccharide, a derivative of a polysaccharide, or a combination thereof. For example, the barrier can comprise a chitosan material.
US08383061B2	Microfluidic bubble logic devices Fluid-based no-moving part logic devices are constructed from complex sequences of micro- and nanofluidic channels, on-demand bubble/droplet modulators and generators for programming the devices, and micro- and nanofluidic droplet/bubble memory elements for storage and retrieval of biological or chemical elements. The input sequence of bubbles/droplets encodes information, with the output being another sequence of bubbles/droplets or on-chip chemical synthesis. For performing a set of reactions/tasks or process control, the modulators can be used to program the device by producing a precisely timed sequence of bubbles/droplets, resulting in a cascade of logic operations within the micro- or nanofluidic channel sequence, utilizing the generated droplets/bubbles as a control. The devices are based on the principle of minimum energy interfaces formed between the two fluid phases enclosed inside precise channel geometries. Various devices, including logic gates, non-volatile bistable memory, ring oscillators, bubble synchronizers, analysis chips, and printers have been designed.
US08383059B2	Microfluidic interface for highly parallel addressing of sensing arrays Disclosed is a spotter device and methods for the formation of microassays, biochips, biosensors, and cell cultures. The spotter may be used to deposit highly concentrated spots of protein or other materials on a microarray slide, wafer, or other surface. It may also be used to perform various chemistry steps on the same spots. The spotter increases the surface density of substances at each spot by directing a flow the desired substance (or a solution thereof) over the spot area until surface saturation is accomplished. The spotter may be loaded by well plate handling equipment. The spotter uses wells, microfluidic conduits, and orifices to deposit proteins, other biomolecules, or chemicals on a spot on a separate surface. Each orifice is connected to two wells via microconduits. When the spotter contacts a surface, a seal is formed between the orifices and the surface. The same or different substances may be flowed across each orifice. Any number of orifices may be incorporated into a spotter. The spotter is particularly useful for depositing proteins in high concentrations on a surface, since the spotter may be placed on a surface for an extended period of time.
US08383056B2	Blood glucose test instrument kit having modular component parts A blood glucose test instrument kit having modular component parts capable of being assembled into a plurality of different handheld blood glucose test instruments is disclosed. The kit comprises the combination of an interconnection platform adapted to connect to a collection of interoperable modules. The collection of interoperable modules including: a plurality of different measurement engine modules, at least one user interface module, at least one power supply module. A handheld blood glucose test instrument is assembled by the interconnection to the interconnection platform of at least one measurement engine module, at least one user interface module, and at least one power supply module. The inter-module communication among the modules connected thereto to achieve enhanced glucose test instrument reliability by effecting at least one reliability protocol selected from a group of reliability protocols.
US08383052B2	System for a heat balanced FCC forlight hydrocarbon feeds Catalyst regenerators and methods for using same. The regenerator can include a regenerator housing containing a dense phase catalyst bed for receiving a catalyst to be regenerated. A heater can be disposed in the regenerator and can have a fuel nozzle configured to eject a mixture of fuel and an oxygen-lean gas for combustion to supplement the heat to satisfy the reactor heat demand when a light feedstock cracked that may not provide sufficient coke formation on the catalyst to fully satisfy the reactor heat demand.
US08383050B2	Device and method for pressure and flow control in parallel reactors A method and a device for the parallel study of chemical reactions in at least two spatially separated reaction spaces is provided. A device for the parallel study of chemical reactions includes at least the following components: (a) at least two spatially separated reaction spaces; (b) on the reaction space input side, at least one common educt feed for the reaction spaces according to (a); (d) on the reaction space output side, at least one connection per reaction space to at least one holding gas feed common to all the reaction spaces, or subsets of them; (e) on the reaction space output side, and downstream of the connection to the holding gas feed according to (d) in the product flow direction, at least one restrictor per reaction space.
US08383048B2	Microsensor for mercury Methods and devices for detecting a concentration of one or more element in hydrocarbon and/or natural gas in a oil and gas field application. The device including a microstructure having a low thermal mass suspended within a channel, the microstructure includes a supporting layer and a insulating layer; a controllable thermal device in communication with the supporting layer of the microstructure, wherein the controllable thermal device is controllably heated to one or more release temperature of the one or more element; a sensing layer arranged on the insulating layer to absorb molecules of the one or more element from hydrocarbon and/or natural gas; a detecting and measuring resistance device in communication with the sensing layer for measuring the resistance changes caused by absorption of molecules of the one or more element onto the sensing layer at a first temperature and a second temperature, and storing the data on a processor.
US08383042B2	Methods and apparatus for imaging and processing of samples in biological sample containers Disclosed herein is a holder for biological sample containers such as well plates. The holder comprises a flat vacuum bed surrounded by a seal. A container is placed within the seal and a vacuum is applied, pressing and flattening the lower surface of the sample container against the flat vacuum bed. Samples in all portions of the container may then be imaged without the need to refocus on each portion of the container. For imaging, a sample in a well can be illuminated by a beam of light arranged so that a part or all of the sample is illuminated by direct rays that have not passed through the well plate. The beam is redirected to other parts of the well if a single illumination does not cover the whole well, so that the sample to be imaged using a series of partial images.
US08383034B2	Ferritic stainless steel sheet for water heater excellent in corrosion resistance at welded part and steel sheet toughness A ferritic stainless steel sheet for a water heater with excellent corrosion resistance of welds and toughness includes, in terms of mass %, 0.020% or less of C, 0.30 to 1.00% of Si, 1.00% or less of Mn, 0.040% or less of P, 0.010% or less of S, 20.0 to 28.0% of Cr, 0.6% or less of Ni, 0.03 to 0.15% of Al, 0.020% or less of N, 0.0020 to 0.0150% of O, 0.3 to 1.5% of Mo, 0.25 to 0.60% of Nb, and 0.05% or less of Ti, the remainder being composed of Fe and unavoidable impurities, and the ferritic stainless steel sheet satisfying the following formulae (1) and (2): 25≦Cr+3.3Mo≦30 (1) 0.35≦Si+Al≦0.85 (2) wherein Cr, Mo, Si, and Al represent the content (mass %) of Cr, Mo, Si, and Al, respectively.
US08383027B2	Method of fabricating a template for a concave array mold, a concave array mold and a needle array sheet A method of fabricating a template (14) for a concave array mold (30) having a plurality of recesses of a high aspect ratio includes arranging a plurality of needles (10) in a mutually separated state and fixing the plurality of the arranged needles (10). This method allows a template for a concave array mold having a high aspect ratio structure to be easily and inexpensively fabricated. Further, the thus fabricated template can be used to easily and inexpensively fabricate a concave array mold. Furthermore, a needle array sheet can be fabricated by injecting and fixing a resin solution into the concave array mold (30) and separating the cured resin solution from the concave array mold (30).
US08383024B2	Porous material and method for fabricating same A method for fabricating a porous structure from a first material. The method comprises the acts of mixing the first material with a second material to form a mixture, the first material having a melting point which is lower than the second material, heating the mixture under pressure to a temperature between a melting point of the first material and a melting point of the second material, cooling the molten mixture until it hardens and removing the second material from the first material. The method may also include a subsequent annealing step. There is also described a material suitable for implant, illustratively vertebral or spinal implants, comprising a rigid biocompatible polymer such as PEEK comprising a plurality of interconnected pores. The polymer illustratively has a porosity of between 50% and 85% by volume and in a particular embodiment is able to withstand pressures of up to 20 MPa. The porous PEEK material may also have a minimum thickness in any dimension of one (1) inch.
US08383023B2	Molding method A molding method may include forming a pattern on a surface of a substrate, the pattern and the surface of the substrate having an opposite polarity to each other, providing the substrate on which the pattern is formed with a liquid to form a liquid mold on either the surface of the substrate or the pattern, the liquid having a polarity identical to the polarity of the surface of the substrate or the polarity of the pattern and cooling the liquid mold at a temperature below a freezing point of the liquid to form a solid mold.
US08383021B1	Mixed-layered bismuth-oxygen-iodine materials for capture and waste disposal of radioactive iodine Materials and methods of synthesizing mixed-layered bismuth oxy-iodine materials, which can be synthesized in the presence of aqueous radioactive iodine species found in caustic solutions (e.g. NaOH or KOH). This technology provides a one-step process for both iodine sequestration and storage from nuclear fuel cycles. It results in materials that will be durable for repository conditions much like those found in Waste Isolation Pilot Plant (WIPP) and estimated for Yucca Mountain (YMP). By controlled reactant concentrations, optimized compositions of these mixed-layered bismuth oxy-iodine inorganic materials are produced that have both a high iodine weight percentage and a low solubility in groundwater environments.
US08383016B2	Conductive fine particles and anisotropic conductive material Conductive fine particles have core particle surfaces coated with a metal-plated coating film layer containing nickel and phosphorus and a multilayer conductive layer comprising a palladium layer as the outer surface. The phosphorus content in region A of the metal-plated coating film layer, at a distance of no greater than 20% of the thickness of the entire metal-plated coating film layer from the surface of the core particle, is 7-15 wt % of the entire region A. The phosphorus content in region B of the metal-plated coating film layer, at a distance of no greater than 10% of the thickness of the entire metal-plated coating film layer from the surface of the metal-plated coating film layer on the palladium layer side, is 0.1-3 wt % of the entire region B, and the phosphorus content of the entire metal-plated coating film layer is 7 wt % or greater.
US08383012B2	Electric article comprising at least one element made from a semiconductive polymeric material and semiconductive polymeric composition An electric article, particularly an electric cable or an accessory thereof, such as a cable joint or a cable termination, includes at least one element made from a semiconductive polymeric material, wherein the at least one element is obtained by crosslinking a semiconductive polymeric composition including: (a) at least one elastomeric polymer; (b) a filler mixture including: (i) at least one first carbon black having a dibutyl phthalate (DBP) absorption number of from 250 to 600 ml/100 g; (ii) at least one second carbon black, different from the first one, having a dibutyl phthalate (DBP) absorption number of from 80 to 250 ml/100 g; and (c) at least one graphite having a specific surface area, measured according to the BET method, not higher than 20 m2/g.
US08383007B2	Seeding resins for enhancing the crystallinity of polymeric substructures The present invention provides for a resin mixture that comprises a highly structured resin 40 and a less structured resin 50. The highly structured resin 40 and the less structured resin 50 are mixed to a ratio of between 1:9 and 4:1 by volume, with a more particular ratio of 1:5 to 3:1. The highly structured resin forms ordered micro regions and the ordered micro regions impose order on surrounding less structured resin molecules. The micro regions are essentially groups of the HS resin that will naturally form order structures.
US08383003B2	Polishing systems Described herein are polishing apparatus, polishing formulations, and polymeric substrates for use in polishing surfaces, and related methods. The apparatus, formulations, substrates, and methods may each be used in applications involving the polishing of metal and/or metal-containing surfaces such as semiconductor wafers. The apparatus, formulations, polymeric substrates, and related methods described herein may be used without abrasives, and in some instances, without mechanical friction of a pad surface against the surface to be polished. Therefore, defects on a polished surface due to such mechanical polishing processes may be reduced.
US08382996B2	Metal-clad laminate Metal-clad laminates in which a conductor layer having superior peel strength is formed on a smooth surface of an insulating layer can be obtained by a method comprising (A) a step of preparing a metal-clad laminate precursor by providing one or more sheets of prepreg between two sheets of film having a metal film layer on a support layer, and heating and pressing them under reduced pressure, (B) a step of removing the support layer, (C) a step of removing the metal film layer, and (D) a step of forming a metal film layer on the surface of an insulating layer by electroless plating.
US08382992B2	Reducing waterborne bacteria and viruses by a controlled electric field An apparatus for disinfecting a fluid has a fluid-containing structure; an inward-facing first electrically conductive cylindrical body contained within said fluid-containing structure; an outward-facing electrically conductive-second cylindrical body disposed within said first cylindrical body, in mutually facing parallel and coaxial relation thereto, and spaced apart therefrom to define a fluid-occupiable cavity; a power supply electrically coupled between said first cylindrical body and said second cylindrical body, said power supply producing therebetween an electric field, said field comprising a waveform approximating a series of alternating square wave pulses of opposite polarity, said pulses having a maximum absolute value of approximately 60 volts per centimeter, a complete cycle of said waveform, comprising a first pulse and a succeeding pulse of opposite polarity, recurring with a frequency of between about 2 kHz: and about 5 kHz and providing about 2 amps to about 4 amps.
US08382990B2	Method of removing mercury and/or arsenic from water or mercury from a gas using an extruded onium ion intercalated silane coupling agent reacted layered phyllosilicate The use of a coupling agent containing a mercapto, disulfide, tretrasulfide and/or polysulfide end group provides a mercury removal media having increased reactivity, stability, and mercury removal ability. The mercury removal media described herein is prepared by reacting an organophilic clay containing onium ions with a mercapto, disulfide, tetrasulfide, and/or polysulfide end moiety. Alternatively, the clay can be made organophilic by onium ion reaction prior to or simultaneously with the coupling reaction of the mercapto- or sulfide-end group-containing coupling agent.
US08382985B1	Apparatus, system and process for wastewater purification An apparatus, system, and process for wastewater treatment. The apparatus can include a basin for receiving a liquid to be treated, the liquid having a direction of flow, and a plurality of pendant sheets for supporting the growth of microorganisms, disposed within the basin and in contact with the liquid, wherein the pendant sheets are oriented parallel to the direction of flow of the liquid.
US08382984B2	Method and installation for biologically treating waste water The invention relates to a method for biologically treating waste water, using a set of micro-organisms having different metabolic spectra, in order to eliminate carbon and nitrogen, even phosphorus. Some of the micro-organisms are fixed to mobile solid carriers (2) and form a fluidised fixed biomass. Some of the micro-organisms are free to be used in an activated mud treatment. To this end, a first non-aerated treatment zone (21a) is followed by a second aerated treatment zone (21b); the treated effluent is subjected to a solid/liquid separation by flotation (6) at a speed higher than 10 m/H; and part of the mud recovered by flotation is recirculated (8) towards the activated mud treatment, said recirculation being controlled (9, 10, 11) so that the MES concentration of the effluent subjected to the liquid/solid separation remains compatible with the retained flotation.
US08382982B2	Apparatus merging wetland plants with a floating substrate to treat pollution in any river, lake or body of water Apparatus to treat pollution in rivers, streams, lakes, bays, ports and all bodies of water, employing as methodology wetland plants or macrophytes growing atop a wire or rigid frame basket filled with polygons or other irregular shaped objects of various configurations. The root system of the macrophytes are merged with and grow down amid the substrate composed of small polygons, other irregular shaped hollow, plastic, ceramic objects or other materials. The substrate provides nutrients, oxygen and sanctuary to bacteria, thereby reducing and eliminating pollutants in all bodies of water.
US08382981B2	Frame system for membrane filtration modules A module arrangement (5) according to an embodiment of the invention consists of a plurality of membrane modules (6) arranged in a two dimensional array (7) and extending between upper and lower block-type manifolds (8) and (9), respectively. The array of modules is further divided into sub-groups of modules (10) separated from each other by space (11) extending transversely across the membrane array (7). An integrated support frame (12) is positioned in the space (11) between the sub-groups (10) and is fixed to the upper and lower manifold blocks (8) and (9) to form an integrated support structure within the module array (7).
US08382976B2	Recovery of bitumen from froth treatment tailings A method for recovering a tailings bitumen from a froth treatment tailings, including providing a first feed material which is derived from the froth treatment tailings, conditioning the first feed material in order to produce a conditioned first feed material, providing a second feed material which is derived from the conditioned first feed material, and subjecting the second feed material to solvent extraction in order to produce an extract containing an amount of the tailings bitumen. The method may further include dewatering the conditioned first feed material in order to produce the second feed material and may further include clarifying the extract to produce a clarified extract containing an amount of the tailings bitumen.
US08382975B2	Process for monitoring the curing reaction of a polymeric matrix of a composite material The process for monitoring the curing reaction of a polymeric matrix, in which carbon nanotubes are dispersed whereby a composite material is formed, provides for: arranging an electric circuit comprising at least a generator of a substantially constant voltage, an amperemeter and two electrodes immersed into the composite material, whereby the composite material interposed between the electrodes closes the electrical circuit, and tracing the current intensity value measured by the amperemeter, which is correlated to the progress of the curing reaction of the polymeric matrix, so as to control said progress.
US08382971B2	Method of electrochemical dissolution of ruthenium-cobalt-based alloy A method of electrochemical dissolution of ruthenium-cobalt (Ru—Co)-based alloy is disclosed, in which a Ru—Co-based alloy bulk is subjected into an electrolyte solution comprising about 50 wt. % to 75 wt. % of sulfuric acid, thereby electrolyzing the Ru—Co-based alloy bulk and forming a product solution comprising Ru and Co ions in the electrolyte solution.
US08382968B2	Conductor/insulator/porous film-device and its use with the electrochemiluminescence-based analytical methods A conductor/insulator/porous film device is provided which is used in electrochemiluminescence methods and instrumentation based on the chemical excitation of label molecules with subsequent measurement of the luminescence in order to quantitate analyte concentrations especially in bioaffinity assays.
US08382963B2	Droplet-free coating systems manufactured by arc-evaporation method A droplet-free wear-resistant coating is manufactured by depositing a wear resistant nitride coating containing a nitride layer which contains at least one metal or metal compound of a metal selected from the group consisting of Ti, Cr, Al, Si and combinations thereof, on a surface of a substrate by cathodic-arc evaporation using a Venetian blind filter system in front of an arc cathode; to reduce metal microdroplets and/or metal microparticles in the wear resistant coating compared to an wear resistant coating obtained without a Venetian blind filter system.
US08382957B2	Recycling and material recovery system A method of recovering an organic decomposition product from an organic source may include: a) causing an inert gas to flow through the reduction zone from a reduction inlet to a reduction outlet in such a way that pressure in the reduction zone is maintained above ambient pressure of a local environment for the material recovery system and b) applying electromagnetic wave energy to the organic source in the reduction zone via a bifurcated waveguide assembly in the substantial absence of oxygen to produce at least one gaseous organic decomposition product in the reduction zone that is exhausted from the reduction zone along with the inert gas through the reduction outlet. A material recovery system may include a housing with an inert gas inlet, a reduction zone, and a reduction outlet, an inert gas supply, an electromagnetic wave generator, a bifurcated waveguide assembly, and a controller.
US08382954B2	Belt for conveying wet web A belt for wet-web conveyance which includes a hydrophilic fibrous structure formed by needle punching in a wet-web-side layer thereof and which can be inhibited from increasing in belt width dimension with water absorption of the hydrophilic fibrous structure and from forming base fabric marks. The belt for wet-web conveyance includes a wet-web-side layer including a hydrophilic fibrous structure and a machine-side layer. A base fabric disposed in the belt is constituted of a first woven fabric disposed on the wet-web side and, laminated therewith, a second woven fabric disposed on the press roll side. The first woven fabric is woven from a machine-direction yarn material and a cross-direction yarn material, the machine-direction yarn material being a spun yarn and the cross-direction yarn material being a yarn having a low water absorption.
US08382951B2	Wet-end manufacturing process for bitumen-impregnated fiberboard A process for manufacturing fiberboard by preparing a fiber slurry mixture including containing cellulose fibers and water then atomizing a liquid bituminous material, such as asphalt. The liquid bituminous material is atomized by mixing it with a pressurized gas, such as compressed air, forming a mist comprising droplets of bituminous material having a diameter between 20 microns and 50 microns. A water spray solidifies the bituminous material droplets thereby forming bituminous particles which fall into the fiber slurry within the spray chamber. From there the slurry is sheared, dewatered, and dried, forming a finished fiberboard.
US08382950B2	Recycling of waste coating color The invention provides a method of recovering and recycling waste coating color from papermaking coating process for use as wet end filler. The inventive method overcomes many technical challenges inherent in using waste coating colors as wet end filler such as the coatings having fine pigments that hurts sheet strength more than regular filler, having strong anionic charge and tendency to disturb wet end chemistry, causing excessive foaming, and containing a large amount of hydrophobic binder particles that tend to agglomerate in the white water and deposit on papermaking equipment. The method involves mixing the coatings with fresh filler particles, adding de-foaming agent, adding cationic coagulant, then preflocculating the mixture. This process causes fresh filler particles, pigments and binders in waste coating color to agglomerate together and form stable flocs with defined particle size distribution. Moreover, using such agglomerate as wet end filler was found to improve sheet strength properties by taking advantage of the binding ability of the latex or binders contained in the waste coating color.
US08382947B2	Surface treatment of substrate or paper/paperboard products using optical brightening agent The present invention relates to a process for applying optical brightening agent (OBA) to a sheet of paper or paperboard substrate. The process comprises the step of spraying an aqueous composition comprising an optical brightening agent onto at least one surface of a sized paperboard substrate to form a treated paperboard substrate. The treated paperboard substrate includes a layer of OBA on at least one surface of the paper or paperboard substrate in which the brightness of the treated paper or paperboard substrate is greater than the sized paper or paperboard substrate before treating thereof.
US08382941B2	Plasma reactor with adjustable plasma electrodes and associated methods Plasma reactors with adjustable plasma electrodes and associated methods of operation are disclosed herein. The plasma reactors can include a chamber, a workpiece support for holding a microfeature workpiece, and a plasma electrode in the chamber and spaced apart from the workpiece support. The plasma electrode has a first portion and a second portion configured to move relative to the first portion. The first and second portions are configured to electrically generate a plasma between the workpiece support and the plasma electrode.
US08382933B2	Molecular bonding method with cleaning with hydrofluoric acid in vapor phase and rinsing with deionized water Adhesion by molecular bonding of two free surfaces of first and second substrates, for example formed by monocrystalline silicon wafers, comprises at least successively: a cleaning step of the two free surfaces with hydrofluoric acid in vapor phase to make the two free surfaces hydrophobic, a rinsing step of said free surfaces with deionized water with a time less than or equal to 30 seconds a step of bringing said free surfaces into contact.
US08382929B2	Dual cure adhesive formulations An adhesive composition comprising as principal components, a polymerizable component, an ambient temperature radical polymerization catalyst system and a photoinitiator. The adhesive may optionally comprise an adhesion promoter, a toughener, an epoxy, and a filler material. Further, a two-part reactive adhesive comprising, a first part comprising, (i) at least one free radical-polymerizable monomer, (ii) at least one reducing agent, and (iii) a photoinitiator, and a second part comprising an oxidizing agent that is reactive at ambient temperature with the reducing agent to produce free radicals that are capable of initiating and propagating free radical polymerization.
US08382927B1	Method of and apparatus for reinforcing medical balloons A method is provided for reinforcing medical balloons in order to withstand high internal pressures without excessive dilation of the reinforced balloon. The method calls for the use of a tubular reinforcement sleeve and a device designed for holding the balloon, stretching the reinforcement sleeve, application of yarn wrappings around the reinforcement sleeve, application of adhesive and curing the adhesive.
US08382926B2	Tear propagation-resistant textile sheet material, method making and use thereof A method with which a textile sheet having good mechanical properties in respect to relatively high values regarding tear propagation resistance can be produced. The textile sheets are used in areas that require relatively high tear propagation resistance. The textile sheets also have relatively high peak tensile values and/or elongation at break values. The method for the production of a tear propagation-resistant textile sheet comprises providing a starting textile sheet made of yarns, fibers or filaments formed of at least two elementary filaments and having an arrangement in cross-section like orange segments or pie slices with the segments or slices made of different polymers, and exposing the starting textile sheet to a compressing heat treatment, wherein the polymer segments are permeated and a substantially non-adhesive bond is achieved between the polymer segments. The textile sheet may comprise nonwoven materials having a specific tear propagation resistance of equal to or greater than 0.4 N per g/m2 (according to Zungen method, ASTM D 2261).
US08382923B2	Apparatus and method for manufacturing gypsum board A gypsum board forming device (10) constitutes an apparatus of producing gypsum boards. A layered formation of a lower sheet (1), an upper sheet (2) and a gypsum slurry (6) passes through a forming gate (40). The forming device forms the formation into a plate-like configuration with use of upper and lower plates (20, 30). The upper plate (20) is constituted from a fixed substrate plate (21) and a movable plate (22), and the movable plate is in surface-to-surface contact with the upper sheet of the layered formation. A plurality of actuators (50) is supported by the substrate plate. Each of the actuators applies an upward or downward load (P) to the movable plate locally for a local deformation of the movable plate owing to a deflection thereof. A gate size (T) is locally changed by displacement of the movable plate relative to the substrate plate.
US08382921B1	Apparatus for making miniature explosive powder charges An apparatus for compressing powders and the like including a head assembly with a distensible elastic platen mounted in a chambered header plate containing a pressurizing fluid. The elastic platen distends in response to the pressurizing fluid. Further, a base assembly includes a rigid platen mounted in a base plate. The rigid platen includes a face with at least one cavity, into which is added powder to be compressed. The elastic platen is aligned with the rigid platen, and during compression, the two platens may be held firmly in contact. The pressurizing fluid pumped into the head assembly causes the elastic platen to deform forming a single distention per cavity. The distensions compress the powder to an optimal density. The apparatus safely and easily compact multiple small samples of explosives and the like into miniature charges.
US08382920B2	Methods of producing deformed metal articles A method of making metal articles as well as sputtering targets is described, which involves deforming an ingot to preferred dimensions. In addition, products made by the process of the present invention are further described.
US08382918B2	Steel wire material for spring and its producing method The steel wire material for a spring of the invention contains; C: 0.37-0.54%, Si: 1.7-2.30%, Mn: 0.1-1.30%, Cr: 0.15-1.1%, Cu: 0.15-0.6%, Ti: 0.010-0.1%, Al: 0.003-0.05%, and the balance including iron with inevitable impurities, wherein ferrite decarburized layer depth is 0.01 mm or less, whole decarburized layer depth is 0.20 mm or less, and fracture reduction of area is 25% or more. It alternately may contain; C: 0.38-0.47%, Si: 1.9-2.5%, Mn: 0.6-1.3%, Ti: 0.05-0.15%, Al: 0.003-0.1%, and the balance including iron with inevitable impurities, wherein ferrite decarburized layer depth is 0.01 mm or less.
US08382913B2	Cartridge for a water-conducting domestic appliance comprising a detergent dosing system A cartridge for a water-conducting domestic appliance, in particular a domestic dishwasher, which has a detergent dosing system having at least one detergent dispenser for receiving at least one cartridge, wherein the cartridge has separate chambers for storing at least two detergents, the cartridge including a cartridge housing having at least two chambers formed therein, wherein each chamber has a storage capacity for storing detergent which is greater than the quantities required for one washing cycle.
US08382912B2	Biofilm-removing agent A biofilm-removing agent which effectively removes biofilms is provided.A biofilm-removing agent containing a basic amino acid derivative represented by the following formula (1) or a salt thereof: (wherein R1 represents a linear- or branched-alkyl group having 4 to 18 carbon atoms or a linear- or branched-alkenyl group having 4 to 18 carbon atoms; X and Y each represent a group selected from the groups represented by the following formulas: and m represents an integer from 1 to 5).
US08382904B2	Gas feed installation for machines depositing a barrier layer on containers The present invention relates to a gas feed installation for depositing barrier layers in a container. According to the invention, a balancing step is carried out using a start-up feed device (70) during transient states when the operation passes from a vacuum step, then to a step of depositing a preparatory layer and finally a step of depositing an actual barrier layer on an injector (44) inside a container (42).
US08382898B2	Methods for high volume manufacture of group III-V semiconductor materials The present invention is related to the field of semiconductor processing equipment and methods and provides, in particular, methods for the sustained, high-volume production of Group III-V compound semiconductor material suitable for fabrication of optic and electronic components, for use as substrates for epitaxial deposition, for wafers and so forth. In preferred embodiments, these methods are optimized for producing Group III-N (nitrogen) compound semiconductor wafers and specifically for producing GaN wafers. Specifically, the method includes reacting an amount of a gaseous Group III precursor as one reactant with an amount of a gaseous Group V component as another reactant in a reaction chamber under conditions sufficient to provide sustained high volume manufacture of the semiconductor material on one or more substrates, with the gaseous Group III precursor continuously provided at a mass flow of 50 g Group III element/hour for at least 48 hours.
US08382896B2	High throughput screening of crystallization materials High throughput screening of crystallization of a target material is accomplished by simultaneously introducing a solution of the target material into a plurality of chambers of a microfabricated fluidic device. The microfabricated fluidic device is then manipulated to vary the solution condition in the chambers, thereby simultaneously providing a large number of crystallization environments. Control over changed solution conditions may result from a variety of techniques, including but not limited to metering volumes of crystallizing agent into the chamber by volume exclusion, by entrapment of volumes of crystallizing agent determined by the dimensions of the microfabricated structure, or by cross-channel injection of sample and crystallizing agent into an array of junctions defined by intersecting orthogonal flow channels.
US08382894B2	Process for the preparation of silicon wafer with reduced slip and warpage Silicon wafers wherein slip dislocations and warpages during device production are suppressed, contain BMDs with an octahedral shape, and of BMDs at a depth greater than 50 μm from the surface of the wafer, the density of BMDs with diagonal size of 10 nm to 50 nm is ≧1×1012/cm3, and the density of BSFs is ≦1×108/cm3. The present silicon wafers preferably have an interstitial oxygen concentration of 4×1017 atoms/cm3 to 6×1017 atoms/cm3, and a density of BMDs with diagonal size of ≧200 nm of not more than 1×107/cm3.
US08382892B2	Single-phase hydraulic binder, methods for the production thereof and building material produced therewith The invention relates to a monophase amorphous hydraulic binder containing silicon, calcium and oxygen atoms in an arrangement comprising silicate building units having an average connectedness of at least Q1, with none or a part of the calcium atoms being substituted for by a metal atom M[6]x+ sixfold or higher-coordinated with oxygen and/or none or no more than 45 atomic percent of the silicon atoms being substituted for by a metal atom M[4]y+ tetrahedrally coordinated with oxygen, the molar ratio of [CaO+(x/2)·(M[6]x+Ox/2)]:[SiO2+M[4]y+Oy/2] having a value of 0.2 to 1.5, and the binder having less than 3.5% by weight of water, as well as a mixture containing this binder. Furthermore, the invention relates to methods for manufacturing the binder or a mixture containing this binder by reaction grinding a starting material containing silicate building units having a connectedness of Q0 to Q2, with a solid silicate raw material having a connectedness of the silicate building units of Q3 to Q4 and optionally drying the monophase hydraulic binder to a water content of below 3.5% by weight.Finally, the invention relates to a building material made by setting the binder or a mixture containing this binder with water and subsequent hardening.
US08382887B1	System for decontaminating industrial output gases The system for decontaminating industrial output gases may process both particulate and gaseous emissions from industrial facilities. The system may be located with or adjacent to an industrial facility or at some distance from the facility. In one embodiment the system includes a subsystem of alternating active and inactive filters, and a wash subsystem cleaning the inactive filters during the cycle. The wash water is captured in a basin for further processing of the chemical particulates therein. Fans located downstream of the filters draw the gaseous industrial output through the filters. Remaining vapor passes to a classification plant where the gases are separated into their constituent elements or compounds. Gases that to are allowed to escape may be burned, and the resulting gases recirculated through the system. Another embodiment is adapted for processing steam, and cools the steam for use as liquid water, rather than allowing it to escape as vapor.
US08382886B2	Cavitation phase separators for steam-based generating systems A system, apparatus and method for generating electricity from renewable geothermal, wind, and solar energy sources includes a heat balancer for supplementing and regulating the heat energy fed to a turbine generator; a hydrogen-fired boiler for supplying supplementary heat; and an injection manifold for metering controlled amounts of superheated combustible gas into the working fluids to optimize efficiency. Moreover, wind or solar power may be converted to hydrogen in an electrolysis unit to produce hydrogen. A phase separator unit that operates by cavitation of the geothermal fluids removes gases from the source fluid. A pollution prevention trap may be used to remove solids and other unneeded constituents of the geothermal fluids to be stored or processed in a solution mining unit for reuse or sale. Spent geothermal and working fluids may be processed and injected into the geothermal strata to aid in maintaining its temperature or in solution mining of elements in the lithosphere.
US08382881B2	Method for removal of mercury from hydrocarbon feedstocks The invention provides a method for removing mercury from a liquid or gas hydrocarbon stream, mixtures thereof, including mixtures of liquid streams with a solid carbonaceous substance, by contacting the hydrocarbon stream with a composition comprising silver and a support material, wherein the composition as measured by ammonia chemisorption has a surface acidity in the range of 0.1-10.0 μmole of irreversible NH3/g of the composition.
US08382875B2	Air cleaner arrangements; serviceable filter elements; and, methods An air cleaner arrangement or assembly is provided. The air cleaner arrangement includes a serviceable filter cartridge. The air cleaner assembly also includes an arrangement for positioning the filter cartridge into a preferred, sealing, orientation and for securing the filter cartridge in that location. Preferred serviceable filter cartridges are provided, as well as methods of assembly and use.
US08382873B2	Safety cabinet A safety cabinet can adapt to variations in body height of a worker or user. The safety cabinet prevents various bacteria from proceeding from the outside of the safety cabinet into a working space of the safety cabinet and prevents bacteria or viruses from proceeding from the working space to the outside of the safety cabinet irrespective of a change in opening area of a front opening. A flow velocity of clean air supplied into the working space and a flow velocity of the air flowing through the front opening are set in accordance with a size of the front opening to maintain physical isolation and prevent contamination. The size of the front opening of the safety cabinet is adjustable.
US08382870B2	Self-cleaning air filter The self-cleaning air filter uses reverse pulse self-cleaning for small scale, small volume air filtration applications, such as vehicles and motorized equipment. The self-cleaning air filter includes a filter casing, a filter element housed within a filter casing, an electronically controlled pulse valve that releases the compressed air pulse, and a pulse pressure relief vent. During the cleaning cycle, the pulse pressure vent opens to vent the compressed air pulse to the atmosphere thereby maintaining the positive pressure differential between the inside and outside of the filter element, which sustains the cleaning action for the duration of the compressed air pulse.
US08382868B2	Cubic boron nitride compact A method of making polycrystalline CBN compacts, high in CBN content, is provided. The method includes making a powdered composition by subjecting a mixture of CBN, present in an amount of at least 80 volume percent of the mixture, and a powdered binder phase to attrition milling. This powdered mixture is subjected to conditions of elevated temperature and pressure suitable to produce CBN compacts.
US08382860B2	Process for producing lithium secondary battery A process for producing a lithium secondary battery employs a charging method where a positive electrode upon charging has a maximum achieved potential of 4.3 V (vs. Li/Li+) or lower. The process includes charging the lithium secondary battery to reach at least a region with relatively flat fluctuation of potential appearing in a positive electrode potential region exceeding 4.3 V (vs. Li/Li+) and 4.8V (vs. Li/Li+) or lower. The lithium secondary battery includes an active material having a solid solution of a lithium transition metal composite oxide having an α-NaFeO2 type crystal structure. The composition ratio of Li, Co, Ni, and Mn contained in the solid solution satisfies Li1+1/3xCo1−x−yNiy/2Mn2x/3+y/2(x+y≦1, 0≦y and 1−x−y=z).
US08382858B2	Nanoparticle-textured surfaces and related methods for selective adhesion, sensing and separation Textured heterogeneous surfaces and related articles as can be used in conjunction with methods for selective sensing and/or separation. When used for selective particle separation such a system can comprise a heterogeneous surface comprising a surface member and a plurality of components extending therefrom, such components spaced about and having a surface density, with heterogeneity comprising different interactions of the surface member and of the extended components with a particle exposed thereto. Various surface heterogeneities and different interactions can be utilized. However, in certain embodiments, competing electrostatic interactions, or a combination of electrostatic and non-electrostatic interactions, with a particle can be utilized. Such a system can utilize a surface member having a charge difference with respect to the components extending therefrom.
US08382857B2	Method for the reactive coloration of leather The present invention relates to a process for dyeing leather with at least one dye F which has at least one alkaline-activable group of the formula A; where - - - - denotes the bond to the rest of the dye molecule; X is halogen, C1-C4-alkyl or C1-C4-alkoxy, k is 0, 1, 2 or 3, n is 0 or 1 and B is a CH═CH2 group or a CH2—CH2-Q group, where Q is an alkaline-detachable group, which comprises treating the leather with an aqueous float comprising at least one dye F at a pH of not less than 8, generally in the region of 8 to 11.
US08382856B2	Hair dye It is an object of the present invention to provide a safe hair dye, which requires a short hair dyeing time, has good hair dyeing property and color tone, and also has an effect of preventing photofading. The present invention provides a hair dye, which comprises a combination of (a) a first agent containing a substance reacting with iron to develop color and an ultraviolet absorbent having a 2-hydroxybenzophenone skeleton, and (b) a second agent containing iron salt.
US08382855B2	Composition and method for colouring hair A composition and method oxidative colours hair based on at least one oxidative dye precursor and comprises one or more surfactants and has a pH below or equal to 7.0 after mixing with a composition comprising at least one oxidizing agent wherein the composition is applied onto hair as foam from a non-aerosol foamer vessel.
US08382852B2	Prosthetic liner with perspiration elimination mechanism A prosthetic elastomeric liner, which can be used without lanyards or straps, in which, upon ambulation, perspiration is voided simultaneously with the reestablishment of a vacuum-aided seal without a vacuum pump. The liner's distal tip comprises a buttress anchored sweat port containing a one way valve continuous with a channel passing through the buttress and liner from its inner surface to its outer surface. The sweat port is connected, optionally integrally, to a prosthetic pin which is inserted into a prosthetic limb.
US08382850B2	Insert for acetabular cup An insert for an acetabular cup includes an insertion body having an external surface shaped to be able to be coupled with a mating seating of the acetabular cup. The insert includes at least a friction element positioned on the external surface to determine a predefined friction with the surface of the seating, so that, during use, the friction element prevents the relative rotation of the insertion body and the acetabular cup.
US08382846B2	Systems and methods for providing deeper knee flexion capabilities for knee prosthesis patients Systems and methods for providing deeper knee flexion capabilities, more physiologic load bearing and improved patellar tracking for knee prosthesis patients. Such systems and methods include (i) adding more articular surface to the antero-proximal posterior condyles of a femoral component, including methods to achieve that result, (ii) modifications to the internal geometry of the femoral component and the associated femoral bone cuts with methods of implantation, (iii) asymmetrical tibial components that have an unique articular surface that allows for deeper knee flexion than has previously been available, (iv) asymmetrical femoral condyles that result in more physiologic loading of the joint and improved patellar tracking and (v) modifying an articulation surface of the tibial component to include an articulation feature whereby the articulation pathway of the femoral component is directed or guided by articulation feature.
US08382845B2	Knee joint prosthesis A knee joint prosthesis including a femoral component for attachment to a femur. The femoral component includes an anterior portion, first and second condylar portions extending from the anterior portion and having first and second bearing surfaces, the first and second condylar portions having first and second posterior ends, and a third condylar portion defined between the first and second condylar portions and extending anteriorly beyond the first and second posterior ends.
US08382844B2	Preservation and restoration of cranial bone flaps Methods are provided for preserving and restoring cranial bone flaps. In one aspect, the method to preserve a cranial bone flap includes cleaning a cranial bone flap, washing the cranial bone flap with a sterile saline solution including gentamycin, and washing the bone with a sterile saline solution including vancomycin. The cranial bone flap may be dried, wrapped, and packaged before being stored in a freezer. The fixing method may include removing the preserved cranial bone flap from a freezer and unwrapping the preserved cranial bone flap from any wrappings. A previous wound may be opened for insertion of the preserved cranial bone flap. The preserved cranial bone flap may be washed with a sterile saline solution including gentamycin and a sterile saline solution including vancomycin. The edges of the previous wound may be refreshed by nipping free margins to expose diploic spaces, and the preserved cranial bone flap may be fixed in place within the previous wound.
US08382842B2	Expandable support device and method of use An expandable support device for tissue repair is disclosed. The device can be used to repair hard or soft tissue, such as bone or vertebral discs. A method of repairing tissue is also disclosed. The device and method can be used to treat compression fractures. The compression fractures can be in the spine. The device can be deployed by compressing the device longitudinally resulting in radial expansion.
US08382834B2	Induction heater system for shape memory medical implants and method of activating shape memory medical implants within the mammalian body A method of altering a medical implant having a shape memory portion includes the use of a probe having a tip provided with an induction coil. The induction coil is electrically coupled to an induction power supply. The induction coil is inserted into the mammalian body. The power supply is activated at a suitable frequency to cause the induction coil to generate a magnetic field, wherein such magnetic field induces eddy currents in the shape memory portion of the implant which are sufficient to heat the shape memory portion of the implant to a phase transformation temperature to effect shape change of the implant.
US08382833B2	Soft-tissue implant having antibacterial effect The invention relates to a soft-tissue implant for use in the medical field which has an antibacterial effect. The soft-tissue implant, which may for example be a breast implant, has at least one antibiotic substance bound to the implant surface in first and second configurations that release the antibiotic substance, after implanting in an animal body, at short term and long term release rates. The first and second configurations are each present at one or more common surface locations. The soft-tissue implant has an antibacterial effect that prevents or reduces the deposition of bacteria and the formation of bacteria-containing biofilms.
US08382822B2	Implantable vascular device A valve prosthesis, such as an artificial venous valve, having a support frame and leaf structure comprising one or more leaflets in which the outer edge of each leaflet engages the inner circumference of the bodily passageway along a serpentine path urged against the passageway by an expandable frame, while the inner edges move in response to fluid to restrict retrograde flow. Optionally, one or more elements can extend from the support frame/leaf structure to provide centering support and/or protection from the leaflet adhering to the vessel wall. In one embodiment, the centering support structure comprises a second or third expandable frames attached to and extending from the proximal and/or distal ends of main valve structure and support frame. In another embodiment, one or more support elements extend outward from the valve support frame to engage the vessel wall to provide greater longitudinal stability.
US08382819B2	Thermoelastic and superelastic Ni-Ti-W alloy A radiopaque nitinol stent for implantation in a body lumen is disclosed. The stent is made from a superelastic alloy such as nickel-titanium or nitinol, and includes a ternary element including tungsten. The added tungsten in specified amounts improve the radiopacity of the nitinol stent comparable to that of a stainless steel stent of the same strut pattern coated with a thin layer of gold. Furthermore, the nitinol stent has improved radiopacity yet retains its superelastic and shape memory behavior and further maintains a thin strut/wall thickness for high flexibility.
US08382817B2	Endoprostheses for peripheral arteries and other body vessels An endoprostheses for implanting in a body lumen, such as a coronary artery, peripheral artery, or other body lumen includes a plurality of elongate strut members spaced apart and extending along a longitudinal axis, each elongate strut member having a plurality of alternating peaks and valley. At least one flexible connecting link connects each elongate strut member to an adjacent elongate strut member. The elongate strut members and connecting links forming a generally tubular stent body having a first delivery diameter and a second implanted diameter. The positioning of the connecting links along the stent body produces desired stent performance characteristics.
US08382814B2	Compliant blood vessel graft Stents and methods of using stents are provided. Stents of the invention provide external support structure for a blood vessel segment disposed within, wherein the stents are capable of resilient radial expansion in a manner mimicking the compliance properties of an artery. The stent may be formed of a knitted or braided mesh formed so as to provide the needed compliance properties. A venous graft with the stent and a vein segment disposed within is provided, wherein graft is capable of mimicking the compliance properties of an artery. Methods of selecting stents for downsizing and methods of using the stents of the invention in downsizing and smoothening are provided. Methods of replacing a section of an artery with a venous graft including a stent of the invention are provided. Methods of reducing intimal hyperplasia in implanted vein segment in a venous graft using stents of the invention are provided.
US08382813B2	Delivery system for a medical device The invention is directed to a delivery system for delivering a medical device. The delivery system includes an inner member having a proximal end and a distal end. The inner member defines a longitudinal axis between the proximal end and the distal end. A tip is formed at the distal end of the inner member. A bumper is freely disposed on the inner member. The bumper has a proximal end and a distal end. A seat is defined between the tip and the distal end of the bumper. Additionally, a sheath is disposed about the inner member, the sheath having a proximal end and a distal end. The sheath is movable from a first sheath position substantially covering the seat, and a second sheath position axially offset to expose the seat. The invention also includes a handle in contact with the proximal end of the inner member.
US08382811B2	Triple lead bone screw A pedicle screw assembly, including: a bone screw having a head portion and a thread portion, wherein the thread portion includes an axial shaft and a triple lead thread disposed about the axial shaft; and a rod retention member selectively coupled to the head portion of the bone screw. Optionally, the triple lead thread includes leads that originate at different points along the axial shaft. Optionally, the triple lead thread includes leads that terminate at different points along the axial shaft. Optionally, the axial shaft includes a first tapering portion proximate a tip of the axial shaft. Optionally, the axial shaft includes a second tapering portion proximate the tip of the axial shaft. Preferably, the second tapering portion tapers more steeply than the first tapering portion. Optionally, the axial shaft includes a reduced diameter portion proximate the head portion. Optionally, the axial shaft includes one or more tapering portions proximate the head portion.
US08382808B2	Bone screw A bone screw has a screw head and a threaded shank. An axial bore into which a plurality of radial bores set at a distance from each other open, extends through the threaded shaft. The axial bore is open at the screw head side end, and the radial bores are also open at the radially outer end. The axial bore is closed in an axial direction in the area of the end of the screw shank that lies opposite the screw head.
US08382802B2	Systems, methods and devices for placement of bone anchors and connectors A device and method for use in spinal surgery are provided.
US08382801B2	Spinous process implants, instruments, and methods Spinous process implants and associated methods are shown and described. In one aspect, the implant limits the maximum spacing between the spinous processes. In another aspect, a spacer has at least one transverse opening to facilitate tissue in-growth. In another aspect, an implant includes a spacer and separate extensions engageable with the spacer. The spacer is provided in a variety of lengths and superior to inferior surface spacings. In another aspect, an implant includes a spacer and a cerclage element offset from the midline of the spacer in use so that the spacer defines a fulcrum and the cerclage element is operative to impart a moment to the vertebrae about the spacer. In another aspect, instrumentation for inserting the implant is provided. In other aspects, methods for treating spine disease are provided.
US08382798B2	Apparatus for sealing a vascular puncture An apparatus for sealing a puncture through a vessel wall including an elongate tubular body, a balloon carried by the body, an outer tubular member carried over the tubular body, and a sealant carried by the tubular body adjacent the balloon. Retracting the outer tubular member exposes the sealant.
US08382796B2	Closure devices, related delivery methods and related methods of use A device for sealing a patent foramen ovale (PFO) in the heart is provided. The device includes a left atrial anchor adapted to be placed in a left atrium of the heart, a right atrial anchor adapted to be placed in a right atrium of the heart, and an elongate member adapted to extend through the passageway and connect the left and right atrial anchors. The right atrial anchor preferably includes a plurality of arms and a cover attached to the arms. The left atrial anchor preferably also includes a plurality of arms and preferably does not include a cover. Preferably, the elongate member has a first end fixedly connected to the left atrial anchor and a portion, proximal to the first end, passing through the right atrial anchor. Preferably, the elongate member is flexible.
US08382793B2	Introducer sheath The invention provides an introducer sheath (1, 21, 51), whose distal end is to be positioned inside a vessel (10, 32, 62), at a predetermined distance from the wall (9, 31, 61) of the vessel (10, 32, 62). The introducer sheath (1, 21, 51) comprises a distal portion (2, 22, 52) with a first diameter and a proximal portion (3, 23, 53) with a second diameter, the first diameter being smaller than the diameter of the puncture hole and the second diameter being larger than the diameter of the puncture hole.
US08382790B2	Manipulator A manipulator includes a hollow joint shaft, wires extending through the joint shaft, pulleys mounted on an end of the joint shaft, for imparting a drive force to the wires, a distal-end working unit mounted on another end of the joint shaft, for being actuated by the wires, and a sealing member for preventing liquid such as blood from flowing from the distal-end working unit through the joint shaft to a connector. The sealing member has holes defined therein, and the wires are slidably inserted through the holes.
US08382789B2	Handle for surgical instruments A handle for surgical instruments that has a “wishbone” configuration. In one embodiment, the instrument is provided with a ratchet mechanism allows two operating handles to be locked in a predetermined position (for example, when the surgical instrument that is maneuvered is in use) or to move relative to each other when the ratchet is partially or fully released (for example, when the surgical instrument that is maneuvered is not in use). In another embodiment, the instrument is provided with a rotary gear mechanism.
US08382788B2	Embolic protection during percutaneous heart valve replacement and similar procedures Various devices are described to provide filtering of flow from the aorta to the left carotid artery and the right carotid artery. The filters can be brought into a desired position through one or more peripheral arteries. A single filter device can provide the desired filtering or a plurality of devices can be used. In particular a single filter device can span between the brachiocephalic artery and the left carotid artery. These filter devices can be used effectively to capture emboli generated during procedures on the heart so that emboli do not travel to the patient's brain where the emboli can cause a stroke or other adverse event. In particular, these filters can be used during percutaneous procedures on the heart, such as endovascular heart valve replacement.
US08382785B2	Apparatus and method for performing cystotomy procedures A cystotomy apparatus includes a sound from which an advancement device having a cutting tip creates a surgical pathway from the bladder through abdominal tissue to the external abdomen along a predetermined path. The cutting tip is captured and removed from the advancement device in a capture cup located in the predetermined path by an alignment structure. The cutting tip is removed from the advancement device while within the capture cup, to allow a dilator, cannula or catheter to be drawn through the surgical pathway into the bladder.
US08382784B2	Vessel cutting devices A catheter-based system for accessing specific body cavities percutaneously and minimizing patient trauma is provided. In the preferred embodiment, in order to create an aperture at an access site in a patient's existing tubular body organ structure, a delivery sheath is passed axially along the interior of a portion of the existing tubular body organ structure to place a distal end of the delivery sheath near the access site. A centering wire is passed axially along the interior of the delivery sheath, piercing through from inside to outside of the patient's existing tubular body organ structure at the access site by causing an end portion of the centering wire to emerge from the distal end of the delivery sheath. A cutting catheter is passed substantially coaxially over the centering wire and axially along the interior of the delivery sheath. The aperture is formed by advancing a distal end of the cutting catheter through from inside to outside of the patient's existing tubular body organ structure at the access site and advancing the distal end of the delivery sheath through from inside to outside of the patient's existing tubular body organ structure at the access site.
US08382783B2	Medical handpiece The medical handpiece of the present invention includes a cutting tool having a flexible shank and a cutting bur, a plastically deformable tubular casing for the cutting tool, a handpiece body detachably holding the cutting tool, bearing members disposed in the casing, an inner intervening member for receiving the shank, and an outer intervening member arranged around the inner intervening member. The inner and outer intervening members are composed of a plurality of segments, and each segment is arranged between or on distal or proximal side of the bearing members. Each segment of the outer intervening member is further composed of a plurality of sub-segments. Annular members having the outer diameter that is larger than that of the outer intervening member are arranged between the sub-segments of the outer intervening member. The present handpiece provides improved operationality since shaking is hardly generated even when the casing is flexed.
US08382782B2	Ultrasonic surgical instruments with partially rotating blade and fixed pad arrangement An ultrasonic surgical instrument that supports an ultrasonically excited blade and an outer sheath that can be selectively rotated relative to each other to bring a distal cutting tip of the blade into contact with at least one cutting surface formed on a distal end of the outer sheath. In some embodiments, the distal cutting tip may contact two cutting surfaces located on opposing sides of an opening in the outer sheath through which the distal cutting tip protrudes. Tissue pads may be attached to the cutting surfaces. Various embodiments also include at least one suction lumen.
US08382781B2	Device for ophthalmic surgery A device for ophthalmic surgery includes a vacuum-pump arrangement for generating a vacuum serving for fixing a suction ring to an eye, an evacuation-path system for transmitting the vacuum to an interface port which permits the separable attachment of a suction-ring instrumentarium including the suction ring, and also a control unit for controlling the vacuum-pump arrangement. In accordance with the invention, the device includes pressure-measuring components for measuring at least the vacuum pressure, the control unit adapted to ascertain a differential pressure between the measured vacuum pressure and an atmospheric pressure. The vacuum-pump arrangement is preferably operated at maximal pumping power in a test-operation mode with suction-ring instrumentarium not attached, in order to ascertain an optimally obtainable relative underpressure in the evacuation-path system. In this way, in the case of fluctuating altitudes of the location of use of the ophthalmic-surgery device and also in the case of fluctuating weather conditions (low pressure, high pressure) it can be ascertained at all times whether the achievable relative underpressure is sufficient.
US08382780B2	Fatigue-resistant gastric banding device A fatigue-resistant inflatable gastric banding device suitable for laparoscopic placement around the stomach of a patient for the treatment of obesity and a method for such treatment are disclosed. The device includes a gastric band having a chambered inflatable member, substantially coextensive with an inner stomach facing surface of the band, that does not crease, wrinkle or fold when adjusted, so as to present a substantially smooth contour along the inner circumference, and to avoid fatigue or failure of the member itself. A gastric band having multiple inflatable compartments or chambers, which may be inflated together or individually is also disclosed.
US08382776B2	Medical devices, systems and methods for rapid deployment and fixation of tissue anchors Medical devices, systems and related methods for delivering a plurality of tissue anchors. The medical devices generally comprise a needle and an over-the-needle suture lock, employed via inner and outer sheaths. The medical systems include a plurality of tissue anchors and at least one biodegradable or resorbable spacer member positioned between adjacent tissue anchors in conjunction with the medical devices.
US08382769B2	Intraocular lens insertion device There is provided an intraocular lens insertion device capable of easily positioning a circumference of an optical portion of an intraocular lens with respect to a distal end of a plunger. An intraocular lens insertion device 1 comprises: a cartridge 3 having a lens placement section 16 in which an intraocular lens 2 is to be placed; an insertion device main body 4 having a plunger 5 for pushing out the intraocular lens 2 with the cartridge 3 being attached to the insertion device main body 4; and a deforming means 6 for deforming the lens placement section 16. A slit 21 is formed on the lens placement section 16, and the deforming means 6 deforms the lens placement section 16 in a diameter-decreasing direction thereof when attaching the cartridge 3 to the insertion device main body 4. In this way, the intraocular lens 2 is settled at a predetermined position in the lens placement section 16, thus making it possible to position a circumference of an optical portion 2a of the intraocular lens 2 with respect to a distal end portion of the plunger 5.
US08382768B2	Apparatus and methods for inserting an implant Methods and apparatus for inserting an implant into a cavity provide for: disposing an implant between opposing first and second ramps of an implant insertion instrument; orienting first and second vertebral contact surfaces of the ramps such that they define an initial, non-zero angle therebetween; inserting the first and second ramps into an intervertebral space of a spine; advancing the implant distally along and between the ramps such that the first and second vertebral contact surfaces of the first and second ramps separate while holding the initial angle substantially constant.
US08382766B2	Connection of cutting blocks The present application relates to a surgical connecting device for connecting a first and second cutting block which each serve to make an incision on a first and second anatomical structure, comprising: a first attaching section for attaching the surgical connecting device to the first cutting block by a mechanical connection; a second attaching section for attaching the surgical connecting device to the second cutting block by a releasable mechanical connection; and a spacing section which spaces the first attaching section away from the second attaching section.
US08382763B2	Modular capture with magnetic attachment A detachable cutting tool capture for a cutting block provides a guide surface to convert an open surface block into a slotted block for plying a surgical cutting tool along the surfaces of the guide during a surgical procedure such as a bone resection with a blade. A magnetized catch provides a convenient device for securing the capture and the block together. A triangular cam on the detachable capture in conjunction with a “v” groove in a magnetized lever of the catch permits a pin of the catch to be selectively retracted from or extended into an aperture of the block when the lever is rotated so that when the pin extends, it serves to secure the combined apparatus for cutting. Mating surfaces of the block and capture provide additional structure for supporting the capture with the block to secure them from relative movement.
US08382761B2	Surgical staple with adjustable width backspan A surgical staple comprising a first deformable leg member having at least a first portion of a staple backspan extending therefrom and a second deformable leg member having at least a second portion of the staple backspan extending therefrom. At least one of the first and second portions of the staple backspan are movable with respect to the other portion to vary the length of the staple backspan.
US08382760B2	Intermarrow nail to be inserted into a fractured long bone The invention concerns an intramedullary nail to be inserted into a fractured long bone, for example a femur, comprising: a rod (2) extending between a proximal part (3) and a distal part (4); a tubular sleeve (5) into which said rod (2) is inserted coaxially; at least a first pair of expansion means (12) located in the distal part (4) of said rod (2), said expansion means (12) being made of a shape-memory material in order to assume a first configuration of rest in which they are disposed inside recesses in the lateral wall of the nail (1), and a second configuration of use in which said means (12) are located projecting from the lateral wall of the nail (1); slots (55) are present on the tubular sleeve (5) in correspondence with the shape-memory means (12) to allow for the fastening onto the bone when the means assume said second configuration of use; where said rod (2) comprises in correspondence with the proximal end (3) a transversal channel (6) for the passage of a stop screw (S), said tubular sleeve (5) comprising a pair of opposite apertures (7a, 7b) placed in alignment with said channel (6); and where the distal part (4) of the rod (2) does not have any through-channel for a screw.
US08382759B2	Intramedullary pin tracking A tracking device for an intramedullary pin whose spatial position is determined and/or tracked in image-guided surgery, including a reference device at a proximal end of the intramedullary pin and a medical navigation system which locates the reference device and determines the orientation of the intramedullary pin from the proximal end. A deformation detection device detects deformations of the intramedullary pin and communicates the deformations to the navigation system. Also provided is a tracking method for determining or tracking the spatial position of an intramedullary pin in image-guided surgery, and to an intramedullary pin that includes a deformation detection device.
US08382756B2	External adjustment device for distraction device A method of positioning an external adjustment device relative to a patient includes placing a magnetic viewing sheet adjacent to a patient and identifying the location of an implanted magnetic assembly using the magnetic viewing sheet by visualizing a magnetic image of the implanted magnetic assembly in the magnetic viewing sheet. The external adjustment device is placed on the patient adjacent to the location where the magnetic image was located.
US08382754B2	Electrosurgical forceps with slow closure sealing plates and method of sealing tissue Electrosurgical bipolar forceps for sealing tissue is disclosed. The forceps includes a shaft member having an end effector assembly disposed at a distal end thereof. The end effector assembly includes jaw members movable from a first position in spaced relation relative to one another to at least one subsequent position wherein the jaw members cooperate to grasp tissue therebetween. Each of the jaw members includes a sealing plate that communicates electrosurgical energy through tissue held therebetween. One or more of the sealing plates includes one or more springs, the sealing plate is configured to slowly flex to accommodate pressure applied to the tissue until a specified closure pressure is obtained based upon at least one of tissue type and tissue thickness.
US08382747B2	Method and apparatus for inflating and deflating balloon catheters A system and method for controlling the inflation, ablation, and deflation of a balloon catheter. The system includes a balloon catheter, a console, a pressurized gas or liquid inflation source, and an umbilical system to deliver pressurized coolant to the balloon catheter. The system may include controller that monitors the amount of pressure and volume within the balloon catheter. During inflation, the pressure and/or volume of fluid within the balloon is maintained at a target amount in order to provide sufficient mechanized pressure against the desired target region. The system limits the inflation pressure such that a safe quantity of gas would be released should a leak occur. If the amount falls below a certain threshold level, gas or fluid egress is presumed and the inflation process is halted.
US08382740B2	Trocarless intravenous cannula with a multifilament tip A trocarless intravenous cannula with a multifilament tip is described. The trocarless intravenous cannula has a tapered, distal multifilament tip that is comprised of a plurality of individual filaments. In one aspect, the distal part of the cannula is fenestrated. The tip and the distal part of the cannula may both be covered in a dry, water-soluble coating.
US08382736B2	Relative stiffness fasteners A fastening member has an inboard end and an outboard end and a panel region, an end region, and a fastening element. The panel region has a proximal edge and a distal edge. The panel region is disposed adjacent to the inboard end and is more extensible than the end region. The end region is disposed adjacent to the outboard end. The end region has a fastening element zone having a first stiffness and an intermediate zone having a second stiffness. The first stiffness is greater than the second stiffness. The intermediate zone is disposed between the fastening element zone and the panel region adjacent to the distal edge. The fastening element is disposed in the end region and defines the fastening element zone.
US08382735B2	Disposable diaper with spaced elastic leg openings for improved appearance A disposable diaper having a neat appearance. The diaper 101 includes: a liquid-permeable top sheet 111 which covers a use surface side; a leakage preventing sheet 112 which covers a non-use surface side; an absorbent body 113 interposed between the top sheet and the leakage preventing sheet; and an external sheet 120 disposed on an outer surface side of the leakage preventing sheet, wherein three-dimensional gathers BS are formed along leg surrounding portions, and leg cut-out portions of the external sheet which form leg openings are located in a portion of the minimum width of a crotch portion, at a position nearer to a central side than places outward by 5 mm from rising start points of the three-dimensional gathers BS.
US08382732B2	Ostomy appliance An ostomy coupling is disclosed comprising a floatable coupling part. The coupling part is supported with respect to an adhesive wafer by means of a flexible support collar that permits displacement of the coupling part in a floatable manner. The flexible collar comprises plastics film and has bistable shapes. The collar is configured to hold the coupling part stably in (i) an extended position spaced from the adhesive wafer, to facilitate an ostomate to manually brace the coupling part in order to relieve the attachment force when an ostomy appliance is press fitted to the coupling part, and (ii) in a retracted position close to the adhesive wafer.
US08382730B2	Surgical fluid basin A surgical fluid basin includes a receptacle member having a lower wall and a peripheral wall extending from the lower wall and arranged about a longitudinal axis, and having an internal chamber within the peripheral wall for reception of fluids. The peripheral wall has at least one terrace defined within the peripheral wall corresponding to a volume of fluid contained within the internal chamber. The at least one terrace defines an internal rise surface and an internal run surface intersecting the internal rise surface. The internal run surface includes indicia markings corresponding to the volume of fluid contained within the internal chamber. A plurality of terraces may be defined within the peripheral wall with each terrace corresponding to a predetermined volume of fluid contained within the internal chamber. The internal run surface defined by each terrace includes indicia markings corresponding to the volume of fluid contained within the internal chamber.
US08382724B2	Systems and methods for radiographically identifying an access port An access port for subcutaneous implantation is disclosed. Such an access port may comprise a body for capturing a septum for repeatedly inserting a needle therethrough into a cavity defined within the body. Further, the access port may include at least one feature structured and configured for identification of the access port subsequent to subcutaneous implantation. Methods of identifying a subcutaneously implanted access port are also disclosed. For example, a subcutaneously implanted access port may be provided and at least one feature of the subcutaneously implanted access port may be perceived. Further, the subcutaneously implanted access port may be identified in response to perceiving the at least one feature. In one embodiment, an identification feature is included on a molded insert that is incorporated into the access port so as to be visible after implantation via x-ray imaging technology.
US08382723B2	Access port identification systems and methods An access port for subcutaneous implantation is disclosed. Such an access port may comprise a body for capturing a septum for repeatedly inserting a needle therethrough into a cavity defined within the body. Further, the access port may include at least one feature structured and configured for identification of the access port subsequent to subcutaneous implantation. Methods of identifying a subcutaneously implanted access port are also disclosed. For example, a subcutaneously implanted access port may be provided and at least one feature of the subcutaneously implanted access port may be perceived. Further, the subcutaneously implanted access port may be identified in response to perceiving the at least one feature.
US08382718B2	Needle assembly and components thereof Needle assemblies are generally discussed herein with particular discussions extended to needle assemblies having a tip protector with a plurality of wall surfaces for preventing contact with the needle tip from a side. Aspects of the tip protectors discussed herein include a first protector body having an arm for blocking a needle tip surrounded by a second protector body having a plurality of wall surfaces.
US08382716B2	Pneumoperitoneum needle Pneumoperitoneum needles for providing and/or insufflating a corporal and/or abdominal cavity are provided. The pneumoperitoneum needle can include a housing, an elongate tubular body extending from a distal surface of the housing, and an elongate hollow tubular rod slidably received within the tubular body. The tubular body preferably includes a passage formed therethrough for connection to a gas administration system. The tubular rod preferably includes a blunt distal end defining an opening, and a proximal end portion defining an opening formed therethrough.
US08382711B2	Intravenous pumping air management systems and methods An intravenous (“IV”) liquid delivery system includes: an IV pump tubing set; a shuttle pump or membrane pump actuator operable with the IV pump tubing set; upstream and downstream valve actuators operable with the IV pump tubing set; the IV pump tubing set including an air removal device; an air detector configured to sense air in the IV pump tubing set; a control unit configured and arranged to (i) open the upstream valve actuator and close the downstream valve actuator to allow the pump actuator to draw liquid into a pump actuation portion of the IV pump tubing set, and (ii) close the upstream valve actuator and open the downstream valve actuator to allow the pump actuator to push liquid out of the pump actuation portion, the system configured to attempt to remove the air via the air removal device while operating the upstream and downstream valve actuators according to (i) and (ii).
US08382706B2	User interface for configuring an invasive cardiology digital signal amplifier and method of use Certain embodiments of the present invention provide systems and methods for catheter input management. Certain embodiments provide a user interface system facilitating catheter monitoring. The system includes a virtual catheter input module (CIM) corresponding to and representing a physical CIM that is adapted to be connected to at least one catheter. The system also includes a configuration module establishing a catheter configuration for the virtual CIM based on a plurality of configuration settings for a catheter channel. At least one catheter channel is assigned to a virtual input port on the virtual CIM. The configuration module applies the catheter configuration for at least one catheter channel when a catheter is connected to a physical input port on the physical CIM corresponding to the virtual input port on the virtual CIM.
US08382700B2	Medical device for glucose monitoring or regulation A medical device comprising a pressure generating means adapted to deliver a liquid, a sensor adapted to measure a flow resistance, and an implantable member comprising an analyte responsive porous membrane which reversibly changes its porosity subject to changes in analyte concentration occurring in the solution surrounding the implantable member. The analyte may in particular be glucose. The medical device may also be used for drug administration.
US08382699B2	Devices and methods for securing a catheter within a heart Devices and methods for securing a catheter within a heart. In at least one embodiment of an apparatus for securing a catheter within a heart, the apparatus comprises a catheter having a proximal end and a distal end and at least one lumen defined therethrough, the catheter defining at least one aperture positioned therethrough at or near the distal end of the catheter, at least one balloon coupled to the catheter and positioned externally to the catheter, and a conduit having a proximal end and a distal end, the distal end of the conduit coupled to the at least one balloon, wherein when the catheter is positioned within an aperture in an atrial wall and when the at least one balloon is positioned at or near the aperture in the atrial wall, inflation of the at least one balloon causes the catheter to be held in place at the atrial wall.
US08382692B1	Neck and spine support device for a neck in flexion A spine and neck support device adapted to support the anatomical structures in the cervical and upper thoracic spine when the user's neck is in flexion. A cushion conforms about the user's anatomical neck structures and rests on the upper chest of the user. The cushion has a chin support area that avoids contacting the user's chin when the user's head is in a neutral position and contacts the user's chin when the user's neck is in flexion. When the user's neck is flexed and the user's chin contacts the chin support area, the cushion unloads and supports the user's neck. At least one and preferably two straps are attached to the cushion and secure it to the user. The top is sloped downwards from back to front to maximize the user's downward field of vision. A groove in the posterior surface of the cushion accommodates the user's trachea/esophagus.
US08382691B2	Orthopedic cast cover anchor assembly and kit for protecting exposed limbs An orthopedic cast cover anchor assembly having a cast anchoring member and a coupler member for coupling the cast anchoring member to form a coupled cast anchor assembly in a generally annular configuration. Also, an orthopedic cast cover kit with at least one cast anchoring member, at least one coupler member for coupling the cast anchoring member to form a coupled cast anchor assembly in a generally annular configuration, and at least one limb protective cover which may be releasably fastened to the fastening portion of the cast anchoring member.
US08382690B2	Portable physis-stimulating device for promoting growth with two-phase ultrasonic vibration generators and led elements Disclosed herein is a growth plate stimulation-type portable growth promotion apparatus including two-phase ultrasonic vibration generators and Light Emitting Diode (LED) devices. The ring-shaped two-phase ultrasonic vibration generators have a center hole. Each of the LED devices is provided in the center hole of the each two-phase ultrasonic vibration generator. The two-phase ultrasonic vibration generators includes a ring-shaped vibration stator configured to have a center hole; a first electrode layer provided under the vibration stator; a second electrode layer provided under the first electrode layer; and a piezoelectric ceramic group layer configured to include a first piezoelectric ceramic group for generating an A phase and a second piezoelectric ceramic group for generating a B phase. Growth plates are stimulated using two-phase ultrasound projected from the two-phase ultrasonic vibration generators and light projected from the LED devices.
US08382684B2	Method and apparatus for displaying 3D images of a part of the skeleton The present invention relates to a method of displaying pressures and forces on a part of the skeleton such as the feet which relate to movements of the human or animal body, especially movements of the lower skeleton, e.g. foot, ankle, knee or hip; as well as to a method of displaying these movements based on the measured pressures and forces on the feet. The present invention also includes apparatus for displaying these pressures and forces and/or movements and software for use in the apparatus. In particular eversion or inversion motion of the foot is displayed.
US08382683B2	Tissue penetration device A moving coil tissue penetration device includes a magnetic source that produces a magnetic field in a magnetically active region. A cylindrical coil is secured to a translation substrate and disposed at least partially within the magnetically active region. A sharpened member is configured to penetrate tissue and mechanically coupled to the translation substrate.
US08382679B2	Autonomic nerve activity measuring apparatus and autonomic nerve activity measuring method An autonomic nerve activity measuring apparatus includes: a pulse wave acquiring unit, configured to acquire at least two pulse wave signals from a living body; an electric stimulation unit, configured to apply electric stimulation to the living body; a comparison unit, configured to compare the pulse wave signals acquired by the pulse wave acquiring unit; and an analysis unit, configured to analyze comparison result provided by the comparison unit.
US08382678B2	Display of target cardiac flow based on cardiac index calculation User interfaces for medical perfusion systems that provide oxygenation, filtering, and recirculation of blood in connection with various medical procedures are provided. In particular, methods of displaying and communicating a desired target flow rate and cardiac index during cardiopulmonary bypass surgeries are provided.
US08382664B2	Molded and undivided medical penetrating device A molded and undivided medical penetrating device comprises a first portion and a second substantially tubular portion having an outer surface, a proximal end and a distal end. The proximal end of the second substantially tubular portion of the device is joined to and is integral with the first portion of the device and is adapted to be maintained essentially outside a body while the first portion of the device is adapted to be retained within the interior of the body. The device includes an opening that extends through the first and second portions of the device and provides access to the interior of the body from outside the body. The opening and the outer surface of the substantially tubular second portion of the device define a wall that is thinner at the proximal end of the second portion than towards the distal end of the second portion.
US08382658B2	Capsule endoscope system A capsule endoscope system includes: a receiving device that receives in-vivo images captured by a capsule endoscope inserted into an organ of a subject; and an image display device that acquires ID information of one or more capsule endoscopes, acquires through the receiving device the in-vivo images captured by the capsule endoscopes identified by the ID information, and displays thereon the in-vivo images thus acquired. The image display device is connected via a communication network to a central server that uniformly manages information about the capsule endoscopes, notifies the central server the ID information of the one or more capsule endoscopes, acquires information about the one or more capsule endoscopes from the central server, and performs a warning process about the one or more capsule endoscopes according to the information thus acquired.
US08382656B1	Apparatus and method for facilitating male orgasm A male masturbation device and method for using same facilitates orgasm without the necessity of the subject achieving an erection. The novel device comprises a housing (14) and accumulator means (12). The accumulator means maintains a consistent modest vacuum within the housing notwithstanding sliding of the penis within the housing. The accumulator means can be integrated with the housing or detached from but in fluid communication with the housing. The device may be used with or without a partner and its use may be augmented by sensory stimulation contrivances. The novel device and method offers the health and recreational benefits of orgasm, and facilitates semen collection, for individuals suffering ED, without resort to drugs or vacuum erection devices. The novel device takes advantage of the fact that an erection is not required for orgasm, however, users may experience an erection prior to ejaculation.
US08382651B2	Devices, systems, and methods to facilitate heart function Devices, systems, and methods for accessing tissue, including the internal and external tissues of the heart, are disclosed. At least some of the embodiments disclosed herein provide access to the internal and external tissues of the heart to assist heart function. In at least one embodiment, a suction/infusion catheter is used to deliver gas to a pericardial space surrounding a heart.
US08382649B2	Delivering foil leaves of selected lengths from an indeterminate length of foil A method and apparatus deliver consecutive foil leaves for use by a hair stylist during the course of a hair styling procedure. Each leaf is of a selected length severed from a supply of foil of indeterminate length, with a unitary tab folded along a fold line extending across the leaf, adjacent a leading edge of the leaf. The foil preferably is drawn from a roll of foil and is advanced along a feed path to a delivery station, and a cutter and folder are moved across the feed path to sever the leaf from the indeterminate length of foil and establish the tab adjacent the leading edge of the leaf. In the preferred arrangement, the cutter and the folder are moved simultaneously along respective arcuate paths by pivotal movement about a common pivotal axis.
US08382644B1	Device for diaphragmal resistive breathing training A training device for diaphragmal breathing exercises, the device including (a) a beaker having a substantially cylindrical shape, with a bottom on one end and an opening on the other end; (b) an inner chamber within the beaker, the inner chamber having a bottom end and an open end on the same side as the open end of the beaker; (c) a lid having inner and outer circumferential ridges, wherein the lid fittingly mounts over the open end of beaker using an outer ridge and fittingly mounts over the inner chamber using the inner ridge; and (d) the lid further having a tubular coupling portion. A breathing tube is fittingly coupled to the tubular coupling portion on one end. A mouthpiece mounted on the other end of the breathing tube. The bottom end of the inner chamber has a stepped shape with a plurality of openings on each step. The lid has a plurality of openings.
US08382643B2	Face lift exercise device A facial exercise device includes a handle, ring, tongue arm and flexible cheek arms. The device is inserted into a person's mouth and the person's cheeks are tightened against the resistance provided by the flexible cheek arms. An optional eyepiece includes connected flexible right and left eye portions and two or more protrusions extending outwardly.
US08382640B2	Control apparatus of clutch mechanism This apparatus is provided with a clutch mechanism 14. The clutch mechanism 14 is interposed between an engine 11 and a transmission 15, and is coupled to a clutch pedal 28. An operating mode of the clutch mechanism 14 changes in conjunction with a change of an operating position of the clutch pedal 28. In the case that an execution condition is met, the apparatus lowers a maximum operating speed of the clutch mechanism 14 in comparison with a state in which an execution condition is not met. The execution condition includes the following execution start condition that “the operating position of the clutch pedal 28 is a position setting the clutch mechanism 14 to a disengaged state, and a changing speed of the operating position of the clutch pedal 28 in an engaging direction at a time of setting the clutch mechanism 14 to an engaged state from the disengaged state is equal to or higher than a predetermined starting speed”.
US08382637B2	Transmission In a transmission having an input disk installed on an input shaft and an output disk installed on an output shaft, a pair of pressure rollers is provided to be movable along a two-axes connecting line of the axes of the input and output shafts, within a disk overlapping area that the input and output disks overlap with each other. The pressure roller pair is configured to sandwich the input and output disks while applying contact pressure from the outside disk faces at a position corresponding to a required transmission ratio, for creating a torque-transmission contacting portion by elastic deformation of the disks. A biasing device is provided for producing a biasing force from which the contact pressure arises. A biasing-force adjustment device is also provided for adjusting the biasing force to produce an appropriate magnitude of contact pressure suited to a shifting condition.
US08382635B2	Epicyclic reduction gear device with balanced planet wheels An epicyclic reduction gear device includes a cylindrical housing (1), having an internal circumference equipped with at least a crown wheel (2), at least a first train-carrier (7) rotatable inside the housing (1) and supporting a first output shaft (13), at least a planetary first wheel set (3a, 3b, 3c), hinged on relative pins (6a, 6b, 6c) fixed at the first train-carrier (7) and provided with related toothed portions (9a, 9b, 9c) engaged with the crown wheel (2), and a solar gear wheel (4) which is integral with an input shaft (10) and which is engaging with the planetary wheels (3a, 3b, 3c). The reduction gear device (12) has at least a first idle gear wheel (5) which is pivoted on the first train-carrier (7) and which engages two wheels (3a, 3b) of the planetary wheels (3a, 3b, 3c) in order to allow force balancing.
US08382634B2	Multistage transmission A multi-stage transmission (1) having a housing (9), a drive shaft (AN), an output shaft (AB), four planetary gear sets (RS1, RS2, RS3, RS4) each having first, second and third elements, at least eight rotatable shafts (1, 2, 3, 4, 5, 6, 7, 8) and six shift elements comprising four clutches (K1, K2, K3, K4) and two brakes (B1, B2). Selective engagement of the clutches and brakes results in different transmission ratios between the drive shaft (AN) and the output shaft (AB) so that up to nine forward gears can be implemented. The multi-stage transmission is delimited by the connections of the individual elements to each other and exactly three of the six shift elements are engaged for each of the up to nine forward gears.
US08382633B2	Axle shaft disconnect assembly A drive axle assembly comprises a carrier member having a trunnion outwardly extending from the carrier member, an output shaft axially outwardly extending from the carrier member, a differential assembly including a differential case supported for rotation within the carrier member and a side gear rotatably mounted about the output shaft, a clutch collar non-rotatably coupled thereto and configured to selectively drivingly engage the side gear, and an annular clutch actuator for axially moving the clutch collar between a first position and a second position. The clutch collar drivingly engages the side gear in power transmitting relationship in the first position, while the clutch collar is disengaged from the side gear in the second position.
US08382626B2	Transmission hydraulic control system having an accumulator A hydraulic control system for actuating at least one torque transmitting device in a transmission includes a sump, a pump in communication with the sump, and an accumulator. A first control device and a second control device control the communication of hydraulic fluid between the pump, the accumulator, and the torque transmitting device.
US08382625B2	Drivetrain device of a vehicle with a gear unit A device (2) for a vehicle drivetrain (1) with a transmission unit (3) for changing various transmission ratios and with a hydraulic device (4). The device (2) can provide a drive torque in the area of the drive output (5) of the vehicle drivetrain (1) and in whose area a drive output torque of the vehicle drivetrain (1) can be at least partially supported. A reversing gear system (6) is connected, upstream of the transmission unit (3), for reversing the rotation direction and the hydraulic device (4) can be brought into active connection with the transmission unit (3) by way of the reversing gear system (6).

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