最新美国发明专利
Document Document Title
US08384317B2 Linear motor device
Provided is a linear motor device which is compact even when a stroke is increased, which can reduce heat generation, and which can eliminate damping force caused by circulating current. The linear motor device includes a linear motor that includes a movable member having a plurality of fields and a stator in which a plurality of armatures including polyphase coils are arranged in line in the moving direction of the movable member, and a controller that sequentially outputs control commands to current amplifiers respectively connected to the armatures in accordance with the relative position of the movable member. The controller selectively outputs the control commands to only the current amplifiers corresponding to the armatures which are opposite the movable member such that the armatures are positioned within a range corresponding to the length in the moving direction of the movable member.
US08384314B2 Traveling wave linear accelerator comprising a frequency controller for interleaved multi-energy operation
An electromagnetic wave having a phase velocity and an amplitude is provided by an electromagnetic wave source to a traveling wave linear accelerator. The traveling wave linear accelerator generates a first output of electrons having a first energy by accelerating an electron beam using the electromagnetic wave. The first output of electrons can be contacted with a target to provide a first beam of x-rays. The electromagnetic wave can be modified by adjusting its amplitude and the phase velocity. The traveling wave linear accelerator then generates a second output of electrons having a second energy by accelerating an electron beam using the modified electromagnetic wave. The second output of electrons can be contacted with a target to provide a second beam of x-rays. A frequency controller can monitor the phase shift of the electromagnetic wave from the input to the output ends of the accelerator and can correct the phase shift of the electromagnetic wave based on the measured phase shift.
US08384310B2 End-of-life circuit for fluorescent lamp ballasts
A ballast and method are presented for detecting end-of-life conditions of fluorescent lamps in which a ballast output is controlled according to a dimming input when a DC voltage or current of the lamp is in a predefined range or when the AC lamp current is below a predefined threshold, and the output is reduced to an EOL protection level when the lamp DC voltage or current is outside the predefined range and the AC lamp current is above the predefined threshold.
US08384309B2 Lighting device, lighting control device, and projector
A lighting device which supplies power to an electrode of a discharge lamp to turn on the discharge lamp, includes: a converting circuit which converts inputted direct current into alternating current; a pulse generating circuit which produces a high-voltage pulse from the alternating current received from the converting circuit and applies the high-voltage pulse to the electrode; and a trigger circuit which is disposed between the converting circuit and causes the pulse generating circuit to apply the high-voltage pulse to the electrode, wherein the trigger circuit allows the pulse generating circuit to apply the high-voltage pulse to the electrode in accordance with a drive frequency of the converting circuit.
US08384306B2 Regulated charge pump and method therefor
In one embodiment, a charge-pump controller is formed to control a value of current supplied to a load. One embodiment of a method of forming a charge pump controller may include configuring no more than three alternately switched switches of the charge pump controller to couple to a capacitor wherein the no more than three alternately switched switches are configured to couple the capacitor in a charging configuration during a first time period and to couple the capacitor to supply a current to an LED during a second time period. Another embodiment of the method may include configuring the charge pump controller to receive a sense signal that is representative of the current and to regulate the current, substantially to a first value.
US08384304B2 LED driver controller
A novel LED driver controller, including: an auto-gain control unit, having an input end coupled to an input voltage signal which is derived from a line voltage, and an output end for providing a normalized signal; a comparator, used to perform voltage comparison on the normalized signal and a current sensing signal to generate a turn-off signal, wherein the turn-off signal will change state from inactive to active when the current sensing signal reaches the normalized signal; and a driving circuit, having a set input end, a reset input end, and an output end, the set input end being coupled to a turn-on signal, the reset input end being coupled to the turn-off signal, the output end being used for providing a gating signal.
US08384303B2 Fluorescent-based electroluminescent lighting
An electroluminescent tube compatible with a conventional fluorescent lighting system is generally described in the present disclosure. One example electroluminescent tube may include a rectifying circuit, a driving circuit, and an electroluminescent device. The driving circuit is configured to drive the electroluminescent device upon receiving a power signal. The rectifying circuit is configured to bypass a starter route and also direct the power signal to the driving circuit through a power input route.
US08384301B2 Light source system capable of dissipating heat
A light source system capable of dissipating heat includes a AC power supply for outputting a first power, a switch device for adjusting an output ratio of the first power according to a light setting, a light emitting device for generating a light source, and a control device for generating an active signal sequence, an heat-dissipation signal sequence and a burst signal according to lighting features of the light emitting device, and combining the active signal sequence and the heat-dissipation signal sequence, to generate a driving signal sequence, for timely outputting the driving signal sequence according to the burst signal, so as to generate the control signal.
US08384300B2 Integrated RF electrodeless plasma lamp device and methods
An RF electrode-less plasma lighting device has a base member, which includes an outer region capable of being coupled to first AC potential and an inner region capable of being coupled to a second AC potential. In a preferred embodiment, the device has an RF module mechanically and integrally coupled to the base member. The RF module has an RF source, which has an output. The RF module has a first DC input and a second DC input. The first DC input of the RF module is coupled to a first DC potential and the second DC input of the RF module is coupled to a second DC potential. In a specific embodiment, the present device has an RF electrodeless plasma lighting assembly integrally coupled to the base member. The RF plasma lighting assembly has an RF input, which is coupled to the output of the RF source.
US08384299B1 Solid state LED bridge rectifier light engine
A solid state light engine includes a bridge rectifier having a rectified output. At least one light emitting diode (LED) is connected to the bridge rectifier, the at least one LED including a die portion, a layer of phosphor free resin positioned upon the die portion, and a plurality of phosphor particles adhered to the layer of phosphor free resin. A pair of AC power input terminals are electrically connected to the input of the bridge rectifier for use in coupling the bridge rectifier to an AC power source. A pair of DC power input terminals are connected to the rectified output of the bridge rectifier for use in coupling the bridge rectifier to a circuit productive of a DC voltage at the pair of DC power terminals. The layer of phosphor free resin includes a polymeric resin.
US08384295B2 Ballast circuit for LED-based lamp including power factor correction with protective isolation
A ballast circuit for a light emitting diode (LED) based lamp including power factor correction with protective isolation. The circuit includes a transformer with electrically isolated windings and a power factor correction circuit that receives no feedback from a secondary winding side of the transformer. An LED-based lamp assembly and a method of driving an LED-based light source are also provided.
US08384285B2 Phosphor, light-emitting device using same, image display and illuminating device
The present invention relates to a phosphor represented by the following general formula (I), comprising: a composite oxide containing a divalent and trivalent metal elements as a host crystal; and at least Ce as an activator element in said host crystal, wherein the phosphor has a maximum emission peak in a wavelength range of from 485 nm to 555 nm in the emission spectrum at room temperature: M1aM2bM3cOd  (I) wherein M1 represents an activator element containing at least Ce; M2 represents a divalent metal element; M3 represents a trivalent metal element; a is a number within a range of 0.0001≦a≦0.2; b is a number within a range of 0.8≦b≦1.2; c is a number within a range of 1.6≦c≦2.4; and d is a number within a range of 3.2≦d≦4.8. Further, a light emitting device comprising said phosphor and a display and a lighting system having said light emitting device as a light source are disclosed. In accordance with the present invention, a phosphor which can be easily produced and can provide a light emitting device having a high color rendering, a light emitting device comprising the phosphor, and a display and a lighting system comprising the light emitting device as a light source can be provided.
US08384275B2 Light emitting element lamp and lighting equipment
An object of the present invention is to provide a light emitting element lamp and a lighting equipment effectively suppressing a temperature rising of a substrate on which a light emitting element is mounted by using a reflector. The present invention provides a light emitting element lamp 1 including: a heat-conductive reflector 2 having an emission opening portion and formed to be widened toward the emission opening portion with a reflecting surface 2a being provided on an inner surface side and an outer peripheral surface being exposed to an outside; a base 4 connected to the reflector 2 via a cover 3; a heat-conductive heat radiating member 8 provided on an inner peripheral surface of the reflector 2 and thermally connected to the reflector 2; a substrate 7 having a light emitting element 6 mounted thereon and attached to the heat radiating member 8 with a substrate surface being thermally connected to the heat radiating member 8 in a surface contact state; a lighting circuit 9 housed in the cover 3 to light the light emitting element 6; and a translucent cover 5 for covering the emission opening portion 2c of the reflector 2.
US08384274B2 High-intensity electromagnetic radiation apparatus and methods
An apparatus for producing electromagnetic radiation includes a flow generator configured to generate a flow of liquid along an inside surface of an envelope, first and second electrodes configured to generate an electrical arc within the envelope to produce the electromagnetic radiation, and an exhaust chamber extending outwardly beyond one of the electrodes, configured to accommodate a portion of the flow of liquid. In another aspect, the flow generator is electrically insulated. In another aspect, the electrodes are configured to generate an electrical discharge pulse to produce an irradiance flash, and the apparatus includes a removal device configured to remove particulate contamination from the liquid, the particulate contamination being released during the flash and being different than that released by the electrodes during continuous operation.
US08384273B2 Piezoelectric vibrating reed, piezoelectric vibrator, oscillator, electronic device, radio-controlled clock, and method for manufacturing piezoelectric vibrating reed
This invention is provided a piezoelectric vibrating reed which is capable of decreasing variation in the amount of etching reside as much as possible and suppressing influence of vibration loss on the vibration characteristics as much as possible. A piezoelectric vibrating reed comprising a vibrating section extensive in parallel in a longitudinal direction and a base to which the vibrating section is connected at this proximal end. The base comprises at least a first section and a second section defined from the side of the proximal end of the base long the longitudinal direction. The first section is wider in a transverse direction than the second section.
US08384272B2 Acoustic wave device and method for production of same
A small and highly reliable acoustic wave device and a method for production of the same will be provided. The acoustic wave device has a piezoelectric substrate 1; a SAW element 2 on one main surface of the piezoelectric substrate 1; an outside connection-use conductor 3 formed on the one main surface of the piezoelectric substrate 1 and electrically connected to the SAW element 2; a columnar electrode 10 on the outside connection-use conductor 3; and a protective cover 6 defining inner walls of a vibration space 7 for vibration of the SAW element 2 and planarly surrounding a side surface of the columnar electrode 10.
US08384270B2 Pressure-balanced electromechanical converter
A pressure-balanced electromechanical converter is described including a structure that converts displacement into electrical energy or electrical energy into displacement, said structure designed to separate an enclosed volume for an outside pressure wave channel, wherein said enclosed volume has a filtering pressure transparent connection to said outside pressure wave channel with said filtering connection be pressure transparent to static pressure or low frequency pressure waves and filtering pressure waves at higher frequencies.
US08384269B2 Electrostatic bonding of a die substrate to a package substrate
A transducer apparatus comprises a package substrate and a transducer disposed over a die substrate. The die substrate is disposed over the package substrate. The transducer apparatus also comprises a voltage source connected between the die substrate and the package substrate, and configured to selectively apply an electrostatic attractive force between the die substrate and the package substrate.
US08384267B2 Electrostatic generator comprising an electret film
An electrostatic generator includes a substrate, an electrode formed on or in a surface of the substrate, an electret film provided so as to be opposed to the electrode and an insulating film on an electrode side formed on a surface of the electrode on a side opposed to the electret film.
US08384263B2 Rotating electrical machine having a compact stator
A rotating electrical machine includes a stator including at least two element coils of the same phase each having a plurality of turns and connected to each other through a coil-to-coil connection wire, the element coils being arranged in adjacent slots, respectively; and a rotor rotatably provided to the stator through a gap. The element coils of the same phase are fitted in the adjacent slots so that wound around portions of the element coils partially overlap each other. The coil-to-coil connection wire connects at a coil end portion conductor wires extending from linear conductor wire portions of innermost wires of the element coils contained in the slots.
US08384262B2 Motor rotor and a motor having the same
A motor rotor includes an annular body and a plurality of magnetic bodies installed on an inner lateral surface of the annular body in an irregular manner, to prevent a rotating motor from generating a cogging effect, disperse the frequency of the cogging torque, and reduce the amplitude. Accordingly, noises generated while the motor is operating are reduced, the periodicity of a cogging torque is changed, and cogging torque is reduced.
US08384259B2 Horizontal linear vibrator
A horizontal linear vibrator includes: a cover unit; a bracket providing an internal space between the cover unit and the bracket; a vibration unit including a mass body having an insertion part providing an accommodating space at one surface thereof, mounted in the internal space, and making a horizontal, linear movement; a magnetic field unit providing an electromagnetic force to allow the vibration unit to move horizontally; and one or more sub-mass units inserted in the insertion part in order to adjust a resonance frequency of the vibration unit.
US08384256B2 Rotary electric machine and the method for assembling it
An electric machine (1) comprises; a casing; a stator (3) fixed to the casing and including at least one electrical winding (5); a rotor (4) housed in the casing and rotatably connected to the latter; an electronic circuit (8) for powering the winding (5) at least partly housed in the casing; a cover (2a) for closing the casing to form with the latter a sealed enclosure; a terminal strip (9), accessible from outside the sealed enclosure, for controlling and powering the electronic circuit (8); a heat sink, embodied by the cover (2a), for absorbing the heat produced, in particular, by the electronic circuit (8). The machine (1) also comprises elastic elements (12) operating between the stator (3) and the electronic circuit (8) in such a way as to press the electronic circuit (8) against the heat sink.
US08384250B2 Computer-controlled connector-panel system
A system and method for ensuring that a large number of connectors, such as fiber-optic cable-connectors, which are plugged-into connector-receptacles arrayed across a connector-panel, are not intentionally disconnected by an un-authorized user with malicious intent, or accidentally unplugged by an authorized technician who may be trying to manually pull-out a specific connector for testing or other purposes but, inadvertently, could otherwise unplug a neighboring connector because of not being able to clearly see which plug is actually being removed due to the large number of cables that are connected to the panel. The connectors are locked in place by restraining arms which are controlled by solenoids or motors. Each restraining arm can be commanded to release its respective connector, but only when the correct command from a computer is received. The same system and method can be applied to connector-receptacles arrayed on one or both sides of the panel. The same system and method can be applied to other cables, such as coax cables or Cat 5 cables.
US08384240B2 Power supply control device
When a highly accurate clock is received by a GPS radio wave from a GPS antenna, the highly accurate clock is always generated by locking a phase locked loop (PLL) circuit within a hold-over section of a clock control section in a power supply control unit. When the GPS radio wave cannot be received normally, the highly accurate clock depending on the GPS radio wave is set to a self-running condition not depending on a self-oscillation clock from an internal clock generating section and a time management section automatically corrects the present time data obtained when the standard radio wave is received from a radio wave antenna based on the highly accurate clock. A primary voltage generating section continuously generates the highly accurate clock even when an ignition switch is turned OFF by avoiding voltage variation in battery voltages while the ignition switch is turned ON. Accordingly, the power supply control device can sustain highly accurate time correction and a clock function under any environmental condition and can also control and execution of various functions based on accurate time management.
US08384235B2 Wind turbine generator
An object of the present invention is to provide a wind turbine generator in which a communication channel can be added in communication between a hub and a nacelle, without making a modification to the design of a slip ring. The present invention provides a wind turbine generator in which communication between the hub and the nacelle is performed by superimposing an information signal onto AC power carried over an AC power line between the hub and the nacelle via the slip ring.
US08384233B2 Generator for direct drive wind turbine
Direct driven wind turbine includes a tower, a nacelle, a rotor blade, a radial flux generator with a stator and a rotor, wherein the lamination package of the generator is essential for the transfer of the torque in axial direction. By introducing this additional function to the lamination package, the generator can be provided without additional torque transferring housing. Preferably, the lamination package obtains this additional function by pressing together the laminations between the front plate and end plate by tensile bolts. This gives sufficient strength to transport the torque in axial direction through the laminations to the mounting points of the generator. Preferably, the laminations include cooling fins. Due to these measures the cooling of the generator improves and active cooling may become superfluous or the power can be increased. The housing of the laminations is an expensive, heavy and labor intensive part which is no longer required due to the invention.
US08384231B2 Method of forming a semiconductor die
In one embodiment, semiconductor die having non-rectangular shapes and die having various different shapes are formed and singulated from a semiconductor wafer.
US08384229B2 Semiconductor device and method for manufacturing the same
A semiconductor device permitting the reduction of cost is disclosed. In a semiconductor package wherein electrode pads of a semiconductor chip and corresponding inner leads are electrically coupled with each other through a plurality of bonding wires, sensing wires (second and fourth bonding wires) are made thinner than other bonding wires (first and third bonding wires) coupled to inner leads same as those with the sensing wires coupled thereto, thereby reducing the cost of gold wires to attain the reduction in cost of the semiconductor package.
US08384224B2 Through wafer vias and method of making same
A method of forming and structure for through wafer vias and signal transmission lines formed of through wafer vias. The structure includes, a semiconductor substrate having a top surface and an opposite bottom surface; and an array of through wafer vias comprising at least one electrically conductive through wafer via and at least one electrically non-conductive through wafer via, each through wafer via of the array of through wafer vias extending from the top surface of to the bottom surface of the substrate, the at least one electrically conductive via electrically isolated from the substrate.
US08384222B2 Semiconductor device and manufacturing method thereof
A semiconductor device and manufacturing method thereof are disclosed. The device comprises a semiconductor die, a passivation layer, a wiring redistribution layer (RDL), an Ni/Au layer, and a solder mask. The semiconductor die comprises a top metal exposed in an active surface thereof. The passivation layer overlies the active surface of the semiconductor die, and comprises a through passivation opening overlying the top metal. The wiring RDL, comprising an Al layer, overlies the passivation layer, and electrically connects to the top metal via the passivation opening. The solder mask overlies the passivation layer and the wiring RDL, exposing a terminal of the wiring RDL.
US08384216B2 Package structure and manufacturing method thereof
A manufacturing method of a package structure is provided. A metal substrate is provided. The metal substrate has a first surface where a first seed layer is formed. A patterned insulating layer is formed on the first seed layer and exposes a portion of the first seed layer. A patterned circuit layer is formed on the exposed portion of the first seed layer and covers a portion of the patterned insulating layer. A chip-bonding process is performed to electrically connect a chip to the patterned circuit layer. An encapsulant encapsulating the chip and the patterned circuit layer and covering a portion of the pattered insulating layer is formed. The metal substrate and the first seed layer are removed to expose a bottom surface of the patterned insulating layer and a lower surface of the patterned circuit layer. Solder balls are formed on the lower surface of the patterned circuit layer.
US08384214B2 Semiconductor structure, pad structure and protection structure
A semiconductor structure is provided. The semiconductor structure includes a substrate, a dielectric layer, a pad structure and a protection structure. The dielectric layer is disposed on the substrate. The pad structure is disposed in the dielectric layer. The pad structure includes a plurality of first metal layers and a plurality of plugs which are electrically connected to each other vertically. There is no contact plug disposed between the pad structure and the substrate. The protection structure is disposed in the dielectric layer and encompasses the pad structure.
US08384211B2 Semiconductor apparatus with improved efficiency of thermal radiation
A semiconductor apparatus includes a first stacked body including a first radiator plate, a first insulating layer, a first conductive layer and a first semiconductor element in this order; a second stacked body including a second radiator plate, a second insulating layer, a second conductive layer and a second semiconductor element in this order and configured to be made of a semiconductor material different from that of the first semiconductor element; and a connecting part configured to electrically connect the first conductive layer and the second conductive layer, wherein the first stacked body and the second stacked body are thermally insulated.
US08384210B1 Thermal interface material and semiconductor component including the thermal interface material
A thermal interface material for use in manufacturing a semiconductor component and a method for manufacturing the semiconductor component. The thermal interface material includes a metallic element in combination with either antimony or tin. Suitable metallic elements include gallium or indium. The concentration of antimony or tin is about 2 percent or less by weight of the thermal interface material. A semiconductor chip is mounted to a support substrate and the thermal interface material is disposed on the semiconductor chip. A lid or a heatsink is coupled to the semiconductor chip via the thermal interface material.
US08384209B2 Semiconductor device and method for manufacturing semiconductor device
To reduce defects of a semiconductor device, such as defects in shape and characteristic due to external stress and electrostatic discharge. To provide a highly reliable semiconductor device. In addition, to increase manufacturing yield of a semiconductor device by reducing the above defects in the manufacturing process. The semiconductor device includes a semiconductor integrated circuit sandwiched by impact resistance layers against external stress and an impact diffusion layer diffusing the impact and a conductive layer covering the semiconductor integrated circuit. With the use of the conductive layer covering the semiconductor integrated circuit, electrostatic breakdown (malfunctions of the circuit or damages of a semiconductor element) due to electrostatic discharge of the semiconductor integrated circuit can be prevented.
US08384205B2 Electronic device package and method of manufacture
A method of manufacturing an electronic device package. Coating a first side of a metallic layer with a first insulating layer and coating a second opposite side of the metallic layer with a second insulating layer. Patterning the first insulating layer to expose bonding locations on the first side of the metallic layer, and patterning the second insulating layer such that remaining portions of the second insulating layer on the second opposite side are located directly opposite to the bonding locations on the first side. Selectively removing portions of the metallic layer that are not covered by the remaining portions of the second insulating layer on the second opposite side to form separated coplanar metallic layers. The separated coplanar metallic layers include the bonding locations. Selectively removing remaining portions of the second insulating layer thereby exposing second bonding locations on the second opposite sides of the separated coplanar metallic layers.
US08384201B2 Wafer and method for improving yield rate of wafer
A wafer and a method for improving the yield rate of the wafer are provided. The wafer includes a first and a second circuit units, a first and a second through silicon vias (TSVs), and a first spare TSV. The first and the second circuit units are disposed inside the wafer. The first TSV vertically runs through the wafer and is coupled to the first circuit unit through the front metal of the wafer. The second TSV vertically passes through the wafer and is coupled to the second circuit unit through the front metal of the wafer. When the first or the second TSV has failed, the first spare TSV vertically passes through the wafer to replace the failed first or second TSV.
US08384200B2 Semiconductor device assemblies including face-to-face semiconductor dice and systems including such assemblies
Semiconductor device assemblies include at least first and second semiconductor dice disposed in a face-to-face configuration. At least some of a plurality of conductive structures are electrically and structurally coupled to a bond pad of the first semiconductor die and a bond pad of the second semiconductor die. A first end of each of a plurality of laterally extending conductive elements may be structurally and electrically coupled to a conductive terminal of a substrate, and a second end of each laterally extending conductive element is structurally and electrically coupled to at least one of a bond pad of the first semiconductor die, a bond pad of the second semiconductor die, and a conductive structure. Methods include the fabrication of such assemblies. Electronic systems include at least one electronic signal processing device, at least one input or output device, and at least one memory device including such a semiconductor device assembly.
US08384198B2 Resistance change memory and manufacturing method thereof
According to one embodiment, a resistance change memory includes a first interconnect extending in a first direction, a second interconnect extending in a second direction intersecting with the first direction, and a cell unit which is provided between the first interconnect and the second interconnect. The cell unit includes a non-ohmic element and a memory element. The non-ohmic element includes a first silicon layer of an n-conductivity type and a conducting layer in contact with a first face of the first silicon layer. The memory element stores data according to a reversible change of a resistance state. The first silicon layer includes a first element and a second element as donor.
US08384194B2 Power semiconductor device comprising a plurality of trench IGBTs
A power semiconductor device with improved avalanche capability structures is disclosed. By forming at least an avalanche capability enhancement doped regions with opposite conductivity type to epitaxial layer underneath an ohmic contact doped region which surrounds at least bottom of trenched contact filled with metal plug between two adjacent gate trenches, avalanche current is enhanced with the disclosed structures.
US08384192B2 Methods for forming small-scale capacitor structures
The present disclosure provides small scale capacitors (e.g., DRAM capacitors) and methods of forming such capacitors. One exemplary implementation provides a method of fabricating a capacitor that includes sequentially forming a first electrode, a dielectric layer, and a second electrode. At least one of the electrodes may be formed by a) reacting two precursors to deposit a first conductive layer at a first deposition rate, and b) depositing a second conductive layer at a second, lower deposition rate by depositing a precursor layer of one precursor at least one monolayer thick and exposing that precursor layer to another precursor to form a nanolayer reaction product. The second conductive layer may be in contact with the dielectric layer and have a thickness of no greater than about 50 Å.
US08384191B2 Stack capacitor structure and forming method
The present invention discloses a stack capacitor structure and method of making the same. The top plate of the stack capacitor structure is connected to each other through a connecting node. The method of forming the stack capacitor structure includes providing an insulating substrate with a doped insulating material layer disposed therein. Then, the insulating substrate is patterned to form a trench, wherein an inner sidewall of the trench has a first region and a second region and the doped insulating material layer within the second region is entirely removed to form a hole. Later, a top plate is formed to surround the inner sidewall of the trench, and the top plate fills in the hole. Next, a capacitor dielectric layer is formed to surround the top plate. Finally, a storage node is formed to fill up the trench.
US08384189B2 High performance system-on-chip using post passivation process
The present invention extends the above referenced continuation-in-part application by in addition creating high quality electrical components, such as inductors, capacitors or resistors, on a layer of passivation or on the surface of a thick layer of polymer. In addition, the process of the invention provides a method for mounting discrete electrical components at a significant distance removed from the underlying silicon surface.
US08384183B2 Integrated hall effect element having a germanium hall plate
An integrated circuit and a method of making the integrated circuit provide a Hall effect element having a germanium Hall plate. The germanium Hall plate provides an increased electron mobility compared with silicon, and therefore, a more sensitive Hall effect element.
US08384181B2 Schottky diode structure with silicon mesa and junction barrier Schottky wells
A power diode having a silicon mesa atop the drift region includes a first contact positioned on the silicon mesa. The silicon mesa is highly doped p-type or n-type, and the anode may be formed on the mesa. The mesa may include two separate silicon layers, one of which is a Schottky barrier height layer. Under a forward bias, the silicon mesa provides carriers to achieve desirable forward current characteristics. The substrate has a significantly reduced thickness. The diode achieves reverse voltage blocking capability by implanting junction barrier Schottky wells within the body of the diode. The diode utilizes a deeper portion of the drift region to support the reverse bias. The method of forming the diode with a silicon mesa includes forming the mesa within a window on the diode or by thermally or mechanically bonding the silicon layer to the drift region.
US08384180B2 Gated co-planar poly-silicon thin film diode
A diode has a first contact of a material having a first conductivity type, a second contact of a material having a second conductivity type arranged co-planarly with the first contact, a channel arranged co-planarly between the first and second contacts, a gate arranged adjacent the channel, and a voltage source electrically connected to the gate. A diode has a layer of material arranged on a substrate, a first region of material doped to have a first conductivity type, a second region of material doped to have a second conductivity type, a channel between the first and second regions formed of an undoped region, a gate arranged adjacent the channel, and a voltage source electrically connected to the gate. A method includes forming a layer of material on a substrate, forming a first region of a first conductivity in the material, forming a second region of a second conductivity in the material, arranged so as to provide a channel region between the first and second regions, the channel region remaining undoped, depositing a layer of gate dielectric on the layer of material, arranging a gate adjacent the channel region on the gate dielectric, and electrically connecting a voltage source to the gate.
US08384179B2 Black silicon based metal-semiconductor-metal photodetector
A black silicon based metal-semiconductor-metal photodetector includes a silicon substrate and a black silicon layer formed on the silicon substrate. An interdigitated electrode pattern structure is formed on the black silicon layer, which can be a planar or U-shaped structure. A thin potential barrier layer is deposited at the interdigitated electrode pattern structure. An Al or transparent conductive ITO thin film is deposited on the thin potential barrier layer. A passivation layer is provided on the black silicon layer. In the black silicon based metal-semiconductor-metal photodetector, the black silicon layer, as a light-sensitive area, can respond to ultraviolet, visible and near infrared light.
US08384177B2 Semiconductor device and method of manufacturing a semiconductor device
A semiconductor device has an active region formed on a semiconductor substrate, a trench-type element isolation region formed on the semiconductor substrate, and a diffusion region in which fluorine is diffused that surrounds the element isolation region and is formed on the semiconductor substrate so as not to contact the active region.
US08384174B2 Chip package
A chip package includes: a substrate having a first and a second surfaces; an optical device on the first surface; a conducting layer on the second surface; a passivation layer on the second surface and the conducting layer, wherein the passivation layer has an opening exposing the conducting layer; a conducting bump on the second surface and having a bottom and an upper portions, wherein the bottom portion is disposed in the opening and electrically contacts the conducting layer, and the upper portion is located outside of the opening and extends along a direction away from the opening; a recess extending from a surface of the conducting bump toward an inner portion of the conducting bump; and a light shielding layer on the second surface, extending under the upper portion, and partially located in the recess and overlapping a portion of the conducting bump.
US08384172B2 Image sensor having reflective metal lines under photoelectric conversion devices
An image sensor includes at least one photoelectric conversion device formed in a silicon substrate, at least one lens formed on one side of the photoelectric conversion device and configured to collect light, a dielectric layer formed on the other side of the photoelectric conversion device and a reflective pattern formed on the dielectric layer. The reflective pattern serves as an electrical circuit interconnection and is configured to reflect the light passing through the dielectric layer such that the light is absorbed to the silicon substrate again.
US08384163B2 Layout design tool for semiconductor integrated circuit
Design time (TAT) is reduced in a layout design of a semiconductor integrated circuit having a well supplied with a potential different from a substrate potential. A layout design method of the present invention includes preparing a first cell pattern placed on a semiconductor substrate of a first conductive type, preparing a second cell pattern having a deep well of a second conductive type, placing the first cell pattern in a first circuit region, and placing the second cell pattern in a second region different from the first circuit region. This reduces TAT in chip design.
US08384161B2 Contact optimization for enhancing stress transfer in closely spaced transistors
By appropriately designing the geometric configuration of a contact level of a sophisticated semiconductor device, the tensile stress level of contact elements in N-channel transistors may be increased, while the tensile strain component of contact elements caused in the P-channel transistor may be reduced.
US08384158B2 Chip and electrostatic discharge protection device thereof
An ESD protection device is provided, which includes a P-type doped region, an N-type doped region, a first P+ doped region, a first N+ doped region, a second N+ doped region and a third N+ doped region. The N-type doped region is located in the P-type doped region. The first P+ doped region connected to a pad is located in the N-type doped region. A part of the first N+ doped region is located in the N-type doped region and the residue part thereof is located in the P-type doped region. The second and the third N+ doped regions are located in the P-type doped region and outside the N-type doped region, and are respectively electrically connected to a first power rail and a second power rail. In addition, the second N+ doped region is located between the first and the third N+ doped regions.
US08384153B2 Semiconductor device and manufacturing method of the same
A semiconductor device includes: a substrate; multiple first and second conductive type regions on the substrate for providing a super junction structure; a channel layer on the super junction structure; a first conductive type layer in the channel layer; a contact second conductive type region in the channel layer; a gate electrode on the channel layer via a gate insulation film; a surface electrode on the channel layer; a backside electrode on the substrate opposite to the super junction structure; and an embedded second conductive type region. The embedded second conductive type region is disposed in a corresponding second conductive type region, protrudes into the channel layer, and contacts the contact second conductive type region. The embedded second conductive type region has an impurity concentration higher than the channel layer, and has a maximum impurity concentration at a position in the corresponding second conductive type region.
US08384149B2 Memory cell having a shared programming gate
A semiconductor memory device includes a substrate, and a trench formed in the substrate. First and second floating gates, each associated with corresponding first and second memory cells, extend into the trench. Since the trench can be made relatively deep, the floating gates may be made relatively large while the lateral dimensions of the floating gates remains small. Moreover, the insulator thickness between the floating gate and a sidewall of the trench where a channel region is formed can be made relatively thick, even though the lateral extent of the memory cell is reduced. A programming gate extends into the trench between the first and second floating gates, and is shared, along with a source region, by the two memory cells.
US08384144B2 Metal-insulator-metal capacitors
An interdigitated Metal-Insulator-Metal (MIM) capacitor provides self-shielding and accurate capacitance ratios with small capacitance values. The MIM capacitor includes two terminals that extend to a plurality of interdigitated fingers separated by an insulator. Metal plates occupy layers above and below the fingers and connect to fingers of one terminal. As a result, the MIM capacitor provides self-shielding to one terminal. Additional shielding may be employed by a series of additional shielding layers that are isolated from the capacitor. The self-shielding and additional shielding may also be implemented at an array of MIM capacitors.
US08384143B2 Semiconductor device and manufacturing method therefor
This semiconductor device according to the present invention includes a plurality of cylindrical lower electrodes aligned densely in a memory array region; a plate-like support which is contacted on the side surface of the cylindrical lower electrodes, and links to support the plurality of the cylindrical lower electrodes; a pore portion provided in the plate-like support; a dielectric film covering the entire surface of the cylindrical lower electrodes and the plate-like support in which the pore portion is formed; and an upper electrode formed on the surface of the dielectric film, wherein the boundary length of the part on the side surface of the cylindrical lower electrode which is exposed on the pore portion is shorter than the boundary length of the part on the side surface of the cylindrical lower electrode which is not exposed on the pore portion.
US08384138B2 Defect prevention on SRAM cells that incorporate selective epitaxial regions
An SRAM device and method of forming MOS transistors of the device having reduced defects associated with selective epitaxial growth in moat tip regions is discussed. The SRAM device comprises a core region and a logic region, logic transistors within the logic region of the SRAM, and selective epitaxial regions grown on both source and drain regions; and memory cell transistors within the core region of the SRAM, and having the selective epitaxial regions grown on only one of the source and drain regions. One method of forming the MOS transistors of the SRAM cell comprises forming a gate structure over a first conductivity type substrate to define a channel therein, masking one of the source and drain regions in the core region, forming a recess in the substrate of the unmasked side of the channel, epitaxially growing SiGe in the recess, removing the mask, and forming the source and drain extension regions in source/drain regions.
US08384137B2 Semiconductor device
A semiconductor device includes: a gate electrode, a source electrode and a drain electrode, all of which are provided on top of a first surface of a substrate, and each of which includes multiple fingers; and an ohmic electrode layer. The semiconductor device includes: a gate terminal electrode connecting the fingers of the gate electrode together; a source terminal electrode connecting the fingers of the source electrode together; a drain terminal electrode connecting the fingers of the drain electrode together; and a gate pad placed on top of the ohmic electrode layer, and connecting the ohmic electrode layer to the gate terminal electrode. The semiconductor device further includes: an n type semiconductor layer formed in the substrate; a p type semiconductor layer formed in the n type semiconductor layer; and a reaction layer formed in the interface between the p type semiconductor layer substrate and the ohmic electrode layer.
US08384132B2 System for separation of an electrically conductive connection
An integrated component includes a semiconductor substrate; at least one interconnect applied on the semiconductor substrate; an insulating layer applied on the at least one interconnect; and at least one opening through the insulating layer which interrupts the at least one interconnect into a first section and a second section.
US08384126B2 Low voltage PNPN protection device
A low voltage protection device that includes a silicon substrate comprises an inner layer of a first dopant type. The device also includes a first outer layer of a second dopant type disposed adjacent a first surface of the inner layer and a second outer layer of the second dopant type disposed adjacent a second surface of the inner layer opposite the first surface. The device further includes a first mesa region disposed in a peripheral region of a first side of the low voltage protection device. The first mesa region includes a first area that includes a peripheral portion of a cathode of the low voltage protection device, the cathode formed by diffusing a high concentration of dopant species of the first type on a first surface of the silicon substrate, and a second area comprising a high concentration of diffused dopant species of the second type.
US08384125B2 Structure and method for a silicon controlled rectifier (SCR) structure for SOI technology
A design structure is embodied in a machine readable medium for designing, manufacturing, or testing a design. The design structure includes a P+-N body diode and an N+-P body diode. The P+-N body diode and the N+-P body diode are laterally integrated.
US08384118B2 LED assembly having maximum metal support for laser lift-off of growth substrate
Described is a process for forming an LED structure using a laser lift-off process to remove the growth substrate (e.g., sapphire) after the LED die is bonded to a submount. The underside of the LED die has formed on it anode and cathode electrodes that are substantially in the same plane, where the electrodes cover at least 85% of the back surface of the LED structure. The submount has a corresponding layout of anode and cathode electrodes substantially in the same plane. The LED die electrodes and submount electrodes are ultrasonically welded together such that virtually the entire surface of the LED die is supported by the electrodes and submount. Other bonding techniques may also be used. No underfill is used. The growth substrate, forming the top of the LED structure, is then removed from the LED layers using a laser lift-off process. The extremely high pressures created during the laser lift-off process do not damage the LED layers due to the large area support of the LED layers by the electrodes and submount.
US08384117B2 Light emitting device package and lighting system including the same
Provided are a light emitting device package and a lighting system comprising the same. The light emitting device package comprises a package body having a trench, a metal layer within the trench, and a light emitting device over the metal layer.
US08384115B2 Bond pad design for enhancing light extraction from LED chips
An improved bond pad design for increased light extraction efficiency for use in light emitting diodes (LEDs) and LED packages. Embodiments of the present invention incorporate a structure that physically isolates the bond pads from the primary emission surface, forcing the current to flow away from the bond pads first before traveling down into the semiconductor material toward the active region. This structure reduces the amount of light that is generated in the area near the bond pads, so that less of the generated light is trapped underneath the bond pads and absorbed.
US08384111B2 Method for forming sapphire substrate and semiconductor device
In a semiconductor device fabricated by growing a compound semiconductor layer on a sapphire substrate, a sapphire substrate enabling the semiconductor device to have a high light-extraction efficiency is provided.A plurality of projections 2, 2, . . . are provided at random on a surface of a sapphire substrate 1, and a GaN layer 10 is grown on this surface. Then, a multi-quantum well layer 12, a p-AlGaN layer 14, a p-GaN layer 16, and an ITO layer 18 are formed on the GaN layer 10, and two electrodes 21 and 22 are also formed. In this manner, a semiconductor light-emitting device is fabricated.
US08384110B2 Light emitting device
A lighting emitting device includes a conductive substrate; a first conductive layer formed on the conductive substrate; a second conductive layer formed on the first conductive layer; a second semiconductor layer formed on the second conductive layer; an active layer formed on the second semiconductor layer; a first semiconductor layer being formed on the active layer and including a charge distribution layer; and an insulation layer.
US08384109B2 Semiconductor light-emitting device
A semiconductor light-emitting device including a substrate, an n-type semiconductor layer formed on the substrate, an active layer laminated on the n-type semiconductor layer and capable of emitting a light, a p-type semiconductor layer laminated on the active layer, an n-electrode which is disposed on a lower surface of the semiconductor substrate or on the n-type semiconductor layer and spaced away from the active layer and p-type semiconductor layer, and a p-electrode which is disposed on the p-type semiconductor layer and includes a reflective ohmic metal layer formed on the dot-like metallic layer, wherein the light emitted from the active layer is extracted externally from the substrate side.
US08384108B2 Light emitting device package
A light emitting device package is provided. The light emitting device package comprises a package body comprising a first cavity, and a second cavity connected to the first cavity; a first lead electrode, at least a portion of which is disposed within the second cavity; a second lead electrode, at least a portion of which is disposed within the first cavity; a light emitting device disposed within the second cavity; a first wire disposed within the second cavity, the first wire electrically connecting the light emitting device to the first lead electrode; and a second wire electrically connecting the light emitting device to the second lead electrode.
US08384099B2 GaN based LED having reduced thickness and method for making the same
A device having a carrier, a light-emitting structure, and first and second electrodes is disclosed. The light-emitting structure includes an active layer sandwiched between a p-type GaN layer and an n-type GaN layer, the active layer emitting light of a predetermined wavelength in the active layer when electrons and holes from the n-type GaN layer and the p-type GaN layer, respectively, combine therein. The first and second electrodes are bonded to the surfaces of the p-type and n-type GaN layers that are not adjacent to the active layer. The n-type GaN layer has a thickness less than 1.25 μm. The carrier is bonded to the light emitting structure during the thinning of the n-type GaN layer. The thinned light-emitting structure can be transferred to a second carrier to provide a device that is analogous to conventional LEDs having contacts on the top surface of the LED.
US08384095B2 Organic light emitting display device and method for manufacturing the same
Disclosed are an organic light emitting display device with improved yield and processing efficiency, which includes an interlayer capable of being separated into a hydrophilic region and a hydrophobic region on top of a hole injection layer in an organic light emitting device and a plurality of layers including a light emitting layer and which is fabricated without using a shadow mask, as well as a method for manufacturing the same. The manufacturing method includes preparing a substrate having a plurality of pixel regions defined in a matrix form, arranging an anode in each of the pixel regions, forming a hole injection layer on the anode by the solution process, forming an interlayer with hydrophobic properties on the hole injection layer by a solution process, selectively UV irradiating the interlayer to define a hydrophilic region on the interlayer, forming a light emitting layer on the interlayer by the solution process, and arranging a cathode on the substrate having the light emitting layer.
US08384093B2 Semiconductor light emitting device and method of fabricating the same
Provided is a semiconductor light emitting device. The semiconductor light emitting device includes: a light emitting structure including a first conductive semiconductor layer, a second conductive semiconductor layer, and an active layer between the first and second conductive semiconductor layers; an insulation layer on the second conductive semiconductor layer and including a first hole therein; a second electrode on the second conductive semiconductor layer; and a first electrode on the insulation layer and including a connection portion electrically connected to the first conductive semiconductor layer. The second electrode includes a plurality of line patterns. The connection portion of the first electrode is disposed between the plurality of line patterns of the second electrode and is disposed in the first hole of the insulation layer.
US08384088B2 Vertical light emitting diode having an outwardly disposed electrode
The invention relates to a vertical light emitting diode (VLED) having an outwardly disposed electrode, the vertical light emitting diode comprises a conductive base, a semiconductor epitaxial structure formed on the conductive base, a passivation layer formed at the periphery of the semiconductor epitaxial structure, and a conductive frame formed on the passivation layer and contacting with the edge of the upper surface of the semiconductor epitaxial structure such that the conductive frame is electrically connected to the semiconductor epitaxial structure.
US08384087B2 Thin film transistor, organic light emitting diode display device having the same, and method of fabricating the same
A thin film transistor includes a substrate, a buffer layer on the substrate, a semiconductor layer including source/drain regions and a channel region on the buffer layer, a gate insulating layer corresponding to the channel region, a gate electrode corresponding to the channel region, and source/drain electrodes electrically connected to the semiconductor layer. A polysilicon layer of the channel region may include only a low angle grain boundary, and a high angle grain boundary may be disposed in a region of the semiconductor layer that is apart from the channel region.
US08384084B2 Semiconductor thin film and semiconductor device
After an amorphous semiconductor thin film is crystallized by utilizing a catalyst element, the catalyst element is removed by performing a heat treatment in an atmosphere containing a halogen element. A resulting crystalline semiconductor thin film exhibits {110} orientation. Since individual crystal grains have approximately equal orientation, the crystalline semiconductor thin film has substantially no grain boundaries and has such crystallinity as to be considered a single crystal or considered so substantially.
US08384082B2 Transistor using derivative polymethyl-methacrylate thin film as gate insulator and passivation layer, and fabrication method thereof
Disclosed are a transistor including a gate insulation layer and an organic passivation layer of a polymer thin film, and a fabrication method thereof. The transistor comprises a substrate, a gate electrode formed on the substrate, a gate insulation layer including a polymethacrylic acid thin film, formed on the gate electrode and the substrate, a channel layer formed on the gate insulation layer, source electrode and drain electrode formed on the channel layer so as to expose at least a part of the channel layer, and an organic passivation layer including a polymethacrylic acid thin film, formed on the source electrode, drain electrode and the partially exposed channel layer. The method for fabricating a transistor comprises steps of forming a gate electrode on a substrate, forming a gate insulation layer of a polymethacrylic acid thin film on the gate electrode and the substrate, forming a channel layer on the gate insulation layer, forming source electrode and drain electrode on the channel layer so as to expose at least a part of the channel layer, and forming an organic passivation layer of a polymethacrylic acid thin film on the source electrode, drain electrode and the partially exposed channel layer.
US08384079B2 Oxide semiconductor device
An object is to provide a semiconductor device having a structure in which parasitic capacitance between wirings can be efficiently reduced. In a bottom gate thin film transistor using an oxide semiconductor layer, an oxide insulating layer used as a channel protection layer is formed above and in contact with part of the oxide semiconductor layer overlapping with a gate electrode layer, and at the same time an oxide insulating layer covering a peripheral portion (including a side surface) of the stacked oxide semiconductor layer is formed. Further, a source electrode layer and a drain electrode layer are formed in a manner such that they do not overlap with the channel protection layer. Thus, a structure in which an insulating layer over the source electrode layer and the drain electrode layer is in contact with the oxide semiconductor layer is provided.
US08384078B2 Organic light emitting display device and method of manufacturing the same
An organic light emitting display device and a method for manufacturing the same. The organic light emitting display device includes: an insulating layer formed on a substrate; a resistance layer of oxide semiconductor formed on the insulating layer; a wiring layer connected to both side portions of the resistance layer; an organic layer formed on the upper portion including the resistance layer and the wiring layer; and a capping layer formed on the organic layer to be overlapped with the resistance layer.
US08384077B2 Field effect transistor using oxide semicondutor and method for manufacturing the same
A field effect transistor which includes, on a substrate, at least a semiconductor layer, a passivation layer for the semiconductor layer, a source electrode, a drain electrode, a gate insulating film and a gate electrode, the source electrode and the drain electrode being connected through the semiconductor layer, the gate insulating film being present between the gate electrode and the semiconductor layer, the passivation layer being at least on one surface side of the semiconductor layer, and the semiconductor layer including a composite oxide which comprises In (indium), Zn (zinc) and Ga (gallium) in the following atomic ratios (1) to (3): In/(In+Zn)=0.2 to 0.8  (1) In/(In+Ga)=0.59 to 0.99  (2) Zn/(Ga+Zn)=0.29 to 0.99  (3).
US08384073B2 System for displaying images
A system for displaying images is provided. The system includes a full-color organic electroluminescent device having an anode. A first emitting layer and a second emitting layer are sequentially disposed on the anode. A cathode is disposed on the second emitting layer. The first and second emitting layers include, respectively, a first dopant and a second dopant, wherein the energy gap of the first dopant is different from that of the second dopant.
US08384068B2 Use of acridine derivatives as matrix materials and/or electron blockers in OLEDs
The present invention relates to the use of (hetero)aryl-substituted acridine derivatives as matrix materials in a light-emitting layer of organic light-emitting diodes (OLEDs) and/or in a blocking layer for electrons in organic light-emitting diodes. The present invention further relates to a light-emitting layer which comprises at least one emitter material and at least one matrix material, wherein the matrix material used is at least one (hetero)aryl-substituted acridine derivative, and to an organic light-emitting diode which comprises at least one inventive light-emitting layer, to an organic light-emitting diode which comprises at least one acridine derivative of the formula (I) in a blocking layer for electrons, and to a device selected from stationary and mobile visual display units and illumination units which comprise at least one inventive organic light-emitting diode.
US08384066B2 Polymer light-emitting device, polymer compound, composition, liquid composition, and conductive thin film
Disclosed is a polymer light-emitting device having a light-emitting layer arranged between an anode and a cathode, and a hole transport layer arranged between the light-emitting layer and the anode. This polymer light-emitting device is characterized in that the hole transport layer is a layer containing a polymer compound which contains a repeating unit represented by the general formula (I) below, a repeating unit represented by the general formula (II) below and a repeating unit represented by the general formula (III) below.
US08384064B2 Electroluminescent device
An electroluminescent device comprising a pair of electrodes, and an electroluminescent layer containing at least a luminescent layer, situated between the electrodes. The luminescent layer has a matrix material containing at least one organic compound, and quantum dots whose surfaces are protected by a protective material and that are dispersed in the matrix material. The protective material contains a first protective material. The absolute value of the ionization potential Ip(h), the absolute value of the electron affinity Ea(h), and the band gap Eg(h) of the first protective material, the absolute value of the ionization potential Ip(m), the absolute value of the electron affinity Ea(m), and the band gap Eg(m) of the organic compound, and the band gap Eg(q) of the quantum dots fulfill all of the conditions (A) to (C): (A) Ip(h)Ea(m)−0.1 eV, and (C) Eg(q)
US08384062B2 Memory including vertical bipolar select device and resistive memory element
A memory includes a first vertical bipolar select device including a first base and a first emitter, a first phase change element coupled to the first emitter, a second vertical bipolar select device including a second base and a second emitter, a second phase change element coupled to the second emitter, and a buried word line contacting the first base and the second base.
US08384060B2 Resistive memory device
Provided is a resistive memory device that can be integrated with a high integration density and method of forming the same. In an embodiment, a bit line is formed of copper using a damascene technique, and when the copper bit line, a copper stud may be formed around the copper bit line.
US08384057B2 Phase-change memory device having multiple diodes
A phase-change memory device with an improved current characteristic is provided. The phase-change memory device includes a metal word line, a semiconductor layer of a first conductivity type being in contact with the metal word line, and an auxiliary diode layer being in contact with metal word line and the semiconductor layer.
US08384056B2 Phase change random access memory device and method of manufacturing the same
A phase change random access memory includes a semiconductor substrate, a switching device pattern formed on the semiconductor substrate, a bottom electrode contact pattern formed on the switching device pattern, a phase change layer pattern formed on the bottom electrode contact pattern, and an insulating layer disposed at a portion of an contact surface between the bottom electrode contact pattern and the phase change layer pattern.
US08384053B2 Charged particle beam extraction method and apparatus used in conjunction with a charged particle cancer therapy system
The invention comprises a charged particle beam extraction method and apparatus used in conjunction with charged particle beam radiation therapy of cancerous tumors. The system uses a radio-frequency (RF) cavity system to induce betatron oscillation of a charged particle stream. Sufficient amplitude modulation of the charged particle stream causes the charged particle stream to hit a material, such as a foil. The foil decreases the energy of the charged particle stream, which decreases a radius of curvature of the charged particle stream in the synchrotron sufficiently to allow a physical separation of the reduced energy charged particle stream from the original charged particle stream. The physically separated charged particle stream is then removed from the system by use of an applied field and deflector.
US08384050B2 Ion beam sample preparation thermal management apparatus and methods
Disclosed are embodiments of an ion beam sample preparation thermal management apparatus and methods for using the embodiments. The apparatus comprises an ion beam irradiating means in a vacuum chamber that may direct ions toward a sample, a shield blocking a portion of the ions directed toward the sample, and a shield retention stage with shield retention means that replaceably and removably holds the shield in a position. The shield has datum features which abut complementary datum features on the shield retention stage when the shield is held in the shield retention stage. The shield has features which enable the durable adhering of the sample to the shield for processing the sample with the ion beam. The complementary datum features on both shield and shield retention stage enable accurate and repeatable positioning of the sample in the apparatus for sample processing and reprocessing. A heat sink means is configured to conduct heat away from the sample undergoing sample preparation in the ion beam. The ion beam irradiating means may modulate ion beam intensity between at least two intensities. The shield retention stage may be stationary or rotating.
US08384042B2 Switching micro-resonant structures by modulating a beam of charged particles
When using micro-resonant structures, a resonant structure may be turned on or off (e.g., when a display element is turned on or off in response to a changing image or when a communications switch is turned on or off to send data different data bits). Rather than turning the charged particle beam on and off, the beam may be moved to a position that does not excite the resonant structure, thereby turning off the resonant structure without having to turn off the charged particle beam. In one such embodiment, at least one deflector is placed between a source of charged particles and the resonant structure(s) to be excited. When the resonant structure is to be turned on (i.e., excited), the at least one deflector allows the beam to pass by undeflected. When the resonant structure is to be turned off, the at least one deflector deflects the beam away from the resonant structure by an amount sufficient to prevent the resonant structure from becoming excited.
US08384041B2 Digital radiographic imaging arrays with reduced noise
Exemplary embodiments provide a radiographic array, flat detector panel and/or X-ray imaging apparatus including the same and/or methods for using the same or calibrating the same. Exemplary embodiments can reduce or address noise occurring in the optically sensitive pixels that is temporally not related to image data detected by the optically sensitive pixels or dark reference frames detected by the optically sensitive pixels. Exemplary embodiments can include a capacitive element in a calibration pixel coupled between a row conductive line and a column conductive line in an imaging array.
US08384040B2 Gamma-ray detector and PET apparatus using the same
A medium area (S) filled with liquid xenon (2) is formed between an external cylindrical body (1a) and internal cylindrical body (1b), and a pair of anode pads (11, 12) are disposed in two-dimensional form in opposite end portions of the medium area (S) in the intersection direction with respect to the gamma-ray incident direction. An intermediate electrode (10) is disposed between a pair of anode pads (11, 12), and a plurality of photomultiplier tubes (5) is installed in two-dimensional form in the external cylindrical body (1a). Then, the gamma-ray reaction point within the liquid area (S) is identified from signals output from the anode pads (11, 12) and photomultiplier tubes (5).
US08384037B2 Use of crystal location in nuclear imaging apparatus to minimize timing degradation in a photodetector array
A method, disclosure relates to for improving detection of true coincidence events and differentiating them from events detected from scattered and random gamma photons, comprises receiving electromagnetic radiation at a plurality of photo detectors that was generated by a scintillating crystal impacted by a gamma photon, and processing data received at a subset of the plurality of photo detectors that are closer to a scintillating crystal, thereby improving a timing coincidence window for detecting a coincidence event.
US08384035B2 Lanthanide doped barium phosphorous oxide scintillators
The present invention provides for a composition comprising an inorganic scintillator comprising a lanthanide-doped barium phosphorous oxide useful for detecting nuclear material.
US08384032B2 Method for saving power consumption of position sensitive detector
A method for saving power consumption of a position sensitive detector used in a smart bathroom product includes changing infrared light emitting strength modes depending on the received strength of reflected infrared light. If the emitting mode is already the strongest, and the strength of the reflected infrared light received back from a reflecting object is weak, the method includes conducting multiple subsequent emissions and averaging the returns to estimate a distance to the infrared light reflecting object.
US08384031B2 Apparatus with optical functionality and associated methods
In an exemplary embodiment, an apparatus includes a sensor integrated circuit (IC). The at least one integrated photodetector that is adapted to sense light, and an integrated analog-to-digital converter (ADC). The integrated analog-to-digital converter (ADC) is coupled to the at least one integrated photodetector, and is adapted to convert an output signal of one or more of the at least one integrated photodetector to one or more digital signals. The sensor integrated circuit (IC) further includes an integrated controller that is adapted to facilitate operation of the sensor integrated circuit (IC).
US08384028B2 MS/MS mass spectrometer
During a halt period of time when the introduction of ions is temporarily discontinued to change an objective ion to be selected by a first mass separator in the previous stage, a pulsed voltage having a polarity opposite to that of the ions remaining in a collision cell (4) is applied to an entrance lens electrode (42) and exit lens electrode (44). The ions are pulled by the DC electric field created by this voltage, to be neutralized and removed by colliding with the lens electrodes (42, 44). Thus, the residual ions, which may cause a crosstalk, can be quickly removed from the inner space of the collision cell (4) without contaminating an ion guide (5) to which a radio-frequency is applied. Since no radio-frequency voltage is applied to the lens electrodes (42, 44), the circuit for applying the pulsed voltage can have a simple configuration. Thus, the cost increase is suppressed.
US08384022B1 Methods and apparatus for calibrating ion trap mass spectrometers
A method of calibrating an ion trap having electrodes to which main RF trapping and resonant ejection voltages are applied comprises: identifying, for each of a plurality of ion types having different respective mass-to-charge ratios, an optimum resonant ejection voltage amplitude at which a mass peak quality is optimized when the ion trap mass analyzer is operated at a selected scan rate; determining a best-fit function of the form Vreseject=mc(a+bm), where Vreseject and m represent resonant ejection voltage amplitude and mass-to-charge ratio and a, b and c are constants; identifying, for each of a plurality of ion types, a respective RF voltage amplitude at which ions of each respective type are ejected from the ion trap using a resonant ejection voltage calculated according to the best-fit function; and determining a second best-fit function relating the identified trapping voltage amplitudes to mass-to-charge; ratio.
US08384020B2 Spatially resolved thermal desorption/ionization coupled with mass spectrometry
A system and method for sub-micron analysis of a chemical composition of a specimen are described. The method includes providing a specimen for evaluation and a thermal desorption probe, thermally desorbing an analyte from a target site of said specimen using the thermally active tip to form a gaseous analyte, ionizing the gaseous analyte to form an ionized analyte, and analyzing a chemical composition of the ionized analyte. The thermally desorbing step can include heating said thermally active tip to above 200° C., and positioning the target site and the thermally active tip such that the heating step forms the gaseous analyte. The thermal desorption probe can include a thermally active tip extending from a cantilever body and an apex of the thermally active tip can have a radius of 250 nm or less.
US08384019B2 Introduction of ions into Kingdon ion traps
In a Kingdon ion trap in which harmonic ion oscillation in a potential well in a longitudinal direction is completely decoupled from ion oscillation in a direction transverse to the longitudinal direction, ions enter the trap via an entrance tube extending through, but electrically insulated from, one of the Kingdon trap housing electrodes and located outside the minimum of the potential well in the longitudinal direction. The geometry of the Kingdon trap is arranged so that the oscillating ions introduced through the entrance tube cannot return to the entrance tube until they have performed several longitudinal oscillations during which time heavy ions can be introduced into the trap.
US08384017B2 Subsurface nuclear measurement systems, methods and apparatus
Methods and related systems are described for use for making subterranean nuclear measurements. The system can include a plurality of elongated scintillator members each generating optical signals in response to ionizing radiation. Optical detector units can be optically coupled to at least one end of each elongated scintillator member so as to detect optical signals from each elongated scintillator member. The system can be suitable for permanent or semi-permanent deployment downhole. For example, the system can operate for more than six months in a subterranean deployment measuring cosmic radiation. The system can be suited to monitor density changes in subterranean regions of interest, for example, density changes brought about by steam injection as part of a steam assisted gravity drainage operation.
US08384011B2 Optical detection device and electronic equipment for detecting at least one of an X-coordinate and a Y-coordinate of an object
An optical detection device includes a light emitting element, which is an area sensor, a light emitting lens part for irradiating an object to be measured with a bundle of emission rays emitted from the light emitting element, a light receiving lens part for condensing reflected light from the object, a light receiving element for detecting reflected light from the object condensed by the light receiving lens part, and a signal processing section for processing a light-reception signal from the light receiving element. Based on the light-reception signal from the light receiving element, the signal processing section detects at least one of an x-coordinate or a y-coordinate of the object on an x-y coordinate plane from at least one of a light-spot position or a light-spot shape on the light receiving element.
US08384010B2 Light detection-type touch sensing apparatus
A touch sensing apparatus includes a light source generating a light. The light travels though a light distribution part. A light guide part guides the light to the light distribution part. A light sensing part outputs an output signal corresponding to an intensity of the light incident through the light guide part and the light distribution part when a touch occurs. A light reflection part reflects the light provided to the light distribution part, and a coordinate generating part calculates a coordinate value of the touch using the output signal from the light sensing part.
US08384006B2 Image pickup apparatus
An apparatus includes pixels each having a transistor that transfers a charge of a photoelectric conversion unit, an amplification unit that receives the transferred charge, a scanning unit that supplies, to the transistor, a conductive pulse, a non-conductive pulse, and an intermediate-level pulse having a peak value between the conductive pulse and the non-conductive pulse, a generating unit that generates an image signal using a signal based on a charge transferred in response to the conductive and intermediate-level pulses, and a control unit that changes at least one of a pulse width of the intermediate-level pulse and the peak value in accordance with information on the detected temperature. The conductive and intermediate-level pulses are supplied to the transistor during a light shielding period of the photoelectric conversion unit.
US08384004B1 Real-time multi-mode neutron multiplicity counter
Embodiments are directed to a digital data acquisition method that collects data regarding nuclear fission at high rates and performs real-time preprocessing of large volumes of data into directly useable forms for use in a system that performs non-destructive assaying of nuclear material and assemblies for mass and multiplication of special nuclear material (SNM). Pulses from a multi-detector array are fed in parallel to individual inputs that are tied to individual bits in a digital word. Data is collected by loading a word at the individual bit level in parallel, to reduce the latency associated with current shift-register systems. The word is read at regular intervals, all bits simultaneously, with no manipulation. The word is passed to a number of storage locations for subsequent processing, thereby removing the front-end problem of pulse pileup. The word is used simultaneously in several internal processing schemes that assemble the data in a number of more directly useable forms. The detector includes a multi-mode counter that executes a number of different count algorithms in parallel to determine different attributes of the count data.
US08384003B2 Display device control based on integrated ambient light detection and lighting source characteristics
Systems and methods are provided for a display device including one or more methods for modifying the display brightness by automatically adapting to ambient lighting conditions.
US08384000B2 Apparatus for providing food service
A food service apparatus is provided as an integral, self-contained assembly comprising a food storage unit adapted to contain a plurality of packaged food items under chilled conditions. There also is a countertop, including an exposed upper surface area, attached to the food storage unit. A cabinet module, defining at least one enclosure space, is attached to the countertop. An oven, operable to cook as food item, is removably placed in the at least one enclosure space. A food advertising module is attached to the cabinet module of the assembly.
US08383999B2 Device for heating a sample by microwave radiation
The present invention concerns a device for heating a sample by microwave radiation comprising a source of microwave radiation, a first waveguide for guiding said microwave radiation to an applicator space adapted to receive said sample to be heated, wherein said applicator space is defined by a terminal portion of said first waveguide and an initial portion of a second waveguide extending from said terminal portion of said first waveguide and being arranged at an angle with respect to said first waveguide.
US08383994B2 Transparency having sensors
A transparency, e.g. an aircraft laminated windshield, includes one or more sensors to monitor performance of one or more properties, e.g. a heating arrangement of the windshield, and to generate signals representative of the performance of the properties. One part of a connector, external of the transparency and connected to the sensors is connected to a system positioned in the aircraft. The system receives a signal from each of the sensors, and processes the signals to determine difference between performance of the property as indicated by the signal received and a preferred performance of the property to provide real time monitoring of the performance of the windshield. With this arrangement information regarding the performance of the windshield is available to schedule timely repair or replacement of the windshield that is performing outside of acceptable limits.
US08383992B2 NTC/PTC heating pad
A controllable heating pad, having a heating conductor embedded in the heating pad, a sensing conductor embedded in the heating pad, a resistive material providing a distributed electrical path between the heating conductor and the sensing conductor, a first current sensor to sense a current in the heating conductor and a second current sensor to sense a current in the sensing conductor. A method of controlling a temperature of a heating pad, including the steps of: warming the heating pad to at least a first predetermined temperature by use of an adjustable on/off signal to the controllable switch, measuring currents through an NTC material or a combination of a PTC material and an NTC material; and maintaining a temperature of the heating pad to within a predetermined temperature range by use of the adjustable on/off signal to the controllable switch.
US08383988B2 Glass pane and glass pane arrangement
The invention relates to a glass pane, comprising at least two individual panes and an adhesive layer located in between them, with the glass pane having a local heating area which only extends over part of the overall area of the pane and which can be heated by means of a heating element.
US08383981B2 Seamless laser ablated roll tooling
A system for generating a laser machined tool from a substantially cylindrical work piece. The system includes a laser producing a laser beam, a mask positioned within the laser beam for shaping the laser beam into an image, and an optical system for imaging the laser beam image onto the outer surface of the work piece. The system coordinates rotational and translation movements of the work piece with activation of the laser in order to use the laser image for ablating the outer surface of the work piece, creating microstructures within the surface of the work piece to form the cylindrical tool.
US08383978B2 Steel pipe material weld zone heating apparatus and method
This invention provides a steel pipe material weld zone heating method and apparatus for melting and welding the weld zone of a steel pipe material that during continuous induction heating and welding of moving steel pipe material as the material being heated controls temperature distribution and molten steel shape and weld frequency fluctuation with high accuracy and high efficiency, irrespective of the shape of the heated region of material being heated or the material properties of the material being heated, which comprises a first imaging device, a weld zone temperature distribution computation device, a heating control device, and a variable frequency alternating current power supply device.
US08383975B2 Enhanced withstand voltage micro switch
An enhanced withstand voltage micro switch includes a base and a cap covering the base. The cap has a press element movable up and down. The base has a conductive member depressed by the press element and a connecting section extended upwards. The base also includes a first contact, and a second contact extended from the connecting section and located above the first contact. The conductive member is swung during up and down movement of the press element to connect with the first or the second contact. The connecting section has an isolation portion jutting sideward between the first and second contacts to prevent generation of a conductive layer caused by connection of the conductive member with the first and second contacts on the connecting section. Thus secured insulation can be formed between the first and second contacts to withstand a higher voltage test.
US08383974B2 Switch device
A switch device has a casing, a tubular portion provided on the casing, an upper surface and a lower surface of the tubular portion being opened, a support shaft provided in the tubular portion, a manipulation knob attached to the tubular portion such that an opening in the upper surface is covered therewith, the manipulation knob being turned about the support shaft by manipulation, a first hitting portion provided in the manipulation knob, a first hit portion provided in the tubular portion, the first hitting portion hitting the first hit portion when the manipulation knob is turned to reach a limit of an operating range of a turning operation of the manipulation knob, and a second hitting portion provided in the manipulation knob independently of the first hitting portion.
US08383971B2 Illuminated keyboard
An illuminated keyboard includes keys; a base plate; an LED circuit board on the base plate and comprising a first circuitry and LEDs; a spacer plate on the LED circuit board and comprising units each corresponding to the key, each unit including two first groove connectors, two second groove connectors, and at least one opening each for receiving the LED; an optically transmissive film circuit board on the spacer plate and comprising a second circuitry, switch contacts, and holes, the first or second groove connector passing through the hole; and a rubber plate on the film circuit board and comprising resilient domes each disposed between the key and the switch contact, the dome having a recessed top for retaining the key, a bottom stem, and through holes grouped as groups each around the dome. The first or second groove connectors are adapted to pass through the holes.
US08383970B2 Restraint system for switchgear drawout breakers
A switchgear system includes rail structure having a base coupled to an interior sidewall of a frame. A first member extends from the base and has an upwardly facing surface. The first member has a second surface extending generally transversely to the upwardly facing surface to oppose a surface of the base. A second member extends from the base and has a downwardly facing surface spaced from the upwardly facing surface so as to define a wheel receiving channel there-between. A circuit breaker tuck includes wheels on exterior sidewalls. The wheels are received in the wheel receiving channel to be slidable along the upwardly facing surface, with the upwardly and downwardly facing surfaces limiting movement of the circuit breaker truck about the horizontal axis and the surface of the base and the second surface of the first member limiting movement of the circuit breaker truck about the vertical axis.
US08383967B2 Method and apparatus for indicia selection
An input device that may work in combination with an electronic device is provided. The input device is configured to input one or more adjustable parameters to the electronic device. The input device uses a plurality of concentric rotary dials to input the one or more adjustable parameters. The concentric rotary dials are co-planar with one another, and share a common center, axis or origin with one inside the other. The concentric rotary dials may have different radii from one another. Further, the concentric rotary dials have a plurality of indicia on one surface of the concentric rotary dials (such as the upper surface). Or, the indicia may be on a surface adjacent to the concentric rotary dials (such as on a non-movable faceplate). A user may move the concentric rotary dials to one or more settings in order to select one of the plurality of indicia.
US08383966B2 Key assembly for an electronic device having a multi-character keycap
A key assembly for use in an electronic device is provided. The key assembly includes a plurality of dome switches, a plurality of single-piece keycaps and plurality of actuators which activate the dome switches. Each single-piece keycap has a plurality of character-representing portions identifying a number of keyboard characters which are separated by deforming portions. Each character-representing portion is associated with a separate one of the plurality of dome switches. Each actuator has a first side which is engaged by one of the character-representing portions of the single-piece keycap and a second side which engages the dome switch associated with that character-representing portion.
US08383964B2 Terminal structure, printed wiring board, module substrate, and electronic device
The present invention provides a terminal structure 14 including a terminal 12 having a conductor 40 containing at least one metal selected from the group consisting of gold, silver, and copper, a first layer containing phosphorus and nickel disposed on the conductor 40, and a second layer having a nickel/phosphorus atomic ratio smaller than that of the first layer and containing Ni3P disposed on the first layer; and solder 70 disposed on the second layer of the terminal 12, while the second layer has a thickness of at least 0.35 μm; and a module substrate 100 having the terminal structure.
US08383963B2 Electrical junction box
To provide an electrical junction box having a new structure that includes a plurality of electrical component mounting sections that are open in an upper surface, such that (1) the structure is provided with a drainage groove for preventing accumulation of water without requiring any special space, and (2) the structure can eliminate a problem of heat generation from electrical components. An electrical junction box includes a first and second electrical component mounting section units. A plurality of electrical component mounting sections are arranged in straight lines to from the first and second units, respectively. The first and second electrical component mounting segment units are separated apart from each other by a given distance and are arranged in parallel with each other. A heat radiation drainage groove is provided between opposed portions of peripheral walls that constitute the adjacent first and second units. The heat radiation drainage groove is provided in at least one end with an end opening that extends to ends of the first and second units and is open in an outer peripheral surface.
US08383959B2 Metamaterial spheric alignment mechanism
A chamber or series of chambers is formed from layers of nested shells and used to manipulate a work product within the chambers. The shells are formed from highly ordered material structures, such as superconductors and metamaterials, and the work product is manipulated using energy that is directed from the outside of the chamber, through the nested shells and into the chamber. The nested shells have an open position and a closed position or have a bridge through which a working material can be passed from one set of nested shells to another set of nested shells. The superconducting shells can be type-1 or type-2, and the metamaterial shells can include any combination of a frequency agile metamaterial, a split ring resonator, an artificial structure of a wire medium, a unit cell of an artificial magnetic metamaterial, metamaterial superlattices and any combination thereof, or other highly ordered composite metamaterials.
US08383955B2 Printed circuit board
A printed circuit board (PCB) includes first to fourth layers. A power supply is arranged on the first layer. An electronic component is arranged on the fourth layer. A first via and a second via extend through the PCB and are electrically connected to the electronic component. The PCB further includes third to seventh vias. A length of a transmission path of the current flows from the power supply to electronic component through the third via and the seventh via is almost the same as a length of a transmission path of the current flows from the power supply to the electronic component through the fourth to sixth vias.
US08383950B1 Metal etch stop fabrication method and structure
A first patterned etch stop layer and a first patterned conductor layer are laminated by a dielectric material to a second patterned etch stop layer and a second patterned conductor layer. As the etch stop metal of the first and second patterned etch stop layers is selectively etchable compared to a conductor metal of the first and second patterned conductor layers, the first and second patterned etch stop layers provide an etch stop for substrate formation etch processes. In this manner, etching of the first and second patterned conductor layers is avoided insuring that impedance is controlled to within tight tolerance.
US08383948B2 Flex-rigid wiring board and method for manufacturing the same
A flex-rigid wiring board includes a flexible substrate having a first surface and a second surface on the opposite side of the first surface, a first conductive pattern formed on the first surface of the flexible substrate, a second conductive pattern formed on the second surface of the flexible substrate, and a conductor made of a conductive paste and formed in a first hole penetrating through the flexible substrate such that the first conductive pattern and the second conductive pattern are electrically connected to each other.
US08383946B2 Heat sink
A heat sink capable of being surface-mounted, the heat sink having a 3D shape and comprising a body made of metal, having a rear side which is horizontal and a front side which is at least partially horizontal, such that the front side is partially surface-mounted on a conductive pattern of a printed circuit board (PCB) by pick-and-place and the rear side is attached to the conductive pattern by reflow-soldering.
US08383942B2 Connecting member
A connecting member includes a cable configured to transfer signal, and a resilient component secured to the cable. The cable includes a first connector and a second connector for being electronically connected to two electronic components. The resilient component is elastically deformable between a first state, in which the resilient component and the cable are contracted, spiraled about the second connector in a first direction up to the first connector, shortening a distance between the first and second connectors, and a second state, in which the resilient component and the cable are pulled away from the first connector, thus a greater distance between the first and second connectors.
US08383937B2 Auxiliary support case for at least one piece of electrical equipment
An auxiliary support case for at least one piece of electrical equipment to be wall-mounted is described, such that a mounting seat is defined, which is suitable to receive and hold said at least one piece of electrical equipment. The support case can be removably fixed to a wall-mounted case according to at least two different positions, thereby allowing respective orientations to said at least one piece of electrical equipment.
US08383935B1 Wellhead adapter
An adapter for a wellhead, the well having a casing and a submersible electric pump mounted within the casing, the casing having an upper end and an upwardly opening bore, the adapter including a base plate having forward and rearward ends, the base plate's rearward end being fitted for mounting over the casing's upper end and having a bore opening aperture therethrough, the base plate's forward end being forwardly oblongated and having a wire passage aperture therethrough; an annular case retaining flange having forward and rearward ends, the annular case retaining flange being fixedly attached to and extending downwardly from the base plate; a switch box having a ceiling, a floor, a left wall, a right wall, and a rear wall, the ceiling incorporating the base plate's forward end and the rear wall incorporating the annular case retaining flange's forward end.
US08383929B2 Elongated photovoltaic devices, methods of making same, and systems for making same
Under one aspect, a nonplanar photovoltaic module having a length includes: (a) an elongated nonplanar substrate; and (b) a plurality of solar cells disposed on the elongated nonplanar substrate, wherein each solar cell in the plurality of solar cells is defined by (i) a plurality of grooves around the nonplanar photovoltaic module and (ii) a groove along the length of the photovoltaic module. In some embodiments, each groove of the plurality of grooves about the photovoltaic module, independently, has a repeating pattern, a non-repeating pattern, or is helical. In some embodiments, the module further includes a patterned conductor providing serial electrical communication between adjacent solar cells. In some embodiments, portions of the patterned conductor providing serial electrical communication between adjacent solar cells are within a groove of the plurality of grooves about the photovoltaic module.
US08383927B2 Stacked photovoltaic device and method of manufacturing the same
A back metal electrode, a bottom cell using microcrystalline silicon for a photoelectric conversion layer, a front cell using amorphous silicon for a photoelectric conversion layer, and a transparent front electrode are formed in this order on a supporting substrate. At least one of the concentration of impurities contained in the front photoelectric conversion layer and the concentration of impurities contained in the bottom photoelectric conversion layer is controlled such that the concentration of impurities in the bottom photoelectric conversion layer is higher than the concentration of impurities in the front photoelectric conversion layer. Impurities do not include a p-type dopant or an n-type dopant but are any one, two, or all of carbon, nitrogen, and oxygen.
US08383926B2 Thermoelectric structure and use of the thermoelectric structure to form a textile structure
The thermoelectric structure is formed by a network of wires oriented substantially in a weft direction of the structure. It comprises first and second conducting wires of different kinds, interwoven to form cold and hot junctions distributed respectively in a top plane and a bottom plane. The junctions are alternately cold and hot along any one conducting wire. The thermoelectric structure comprises at least one high dielectric wire in the top plane, and at least one low dielectric wire in the bottom plane. The dielectric wires are interwoven with the first and second conducting wires so as to keep the top and bottom planes at a distance from one another.
US08383921B2 Stick of string instrument bow, string instrument bow and methods of manufacturing stick of string instrument bow
A stick of a string instrument bow includes a base material having an arched-rod shaped carbon fiber resin layer made of carbon fiber resin and a glass fiber resin layer which covers the outer surface of the carbon fiber resin layer and is made of glass fiber resin, and the glass fiber resin layer has a non-adhesion portion formed of an air layer present within the glass fiber resin layer and an adhesion portion which does not include the air layer.
US08383917B2 Wheat variety W00600H3
A wheat variety designated W000600H3, the plants and seeds of wheat variety W000600H3, methods for producing a wheat plant produced by crossing the variety W000600H3 with another wheat plant, and hybrid wheat seeds and plants produced by crossing the variety W000600H3 with another wheat line or plant, and the creation of variants by mutagenesis or transformation of variety W000600H3. This invention also relates to methods for producing other wheat varieties or breeding lines derived from wheat variety W000600H3 and to wheat varieties or breeding lines produced by those methods.
US08383915B1 Maize variety hybrid X8F926
A novel maize variety designated X8F926 and seed, plants and plant parts thereof, produced by crossing Pioneer Hi-Bred International, Inc. proprietary inbred maize varieties. Methods for producing a maize plant that comprises crossing hybrid maize variety X8F926 with another maize plant. Methods for producing a maize plant containing in its genetic material one or more traits introgressed into X8F926 through backcross conversion and/or transformation, and to the maize seed, plant and plant part produced thereby. This invention relates to the maize variety X8F926, the seed, the plant produced from the seed, and variants, mutants, and minor modifications of maize variety X8F926. This invention further relates to methods for producing maize varieties derived from maize variety X8F926.
US08383897B2 Soybean variety A1023763
The invention relates to the soybean variety designated A1023763. Provided by the invention are the seeds, plants and derivatives of the soybean variety A1023763. Also provided by the invention are tissue cultures of the soybean variety A1023763 and the plants regenerated therefrom. Still further provided by the invention are methods for producing soybean plants by crossing the soybean variety A1023763 with itself or another soybean variety and plants produced by such methods.
US08383889B2 Transgenic plants modified for reduced cadmium transport, derivative products, and related methods
Various embodiments are directed to transgenic plants, including transgenic tobacco plants and derivative seeds, genetically modified to impede the transport of Cadmium (Cd) from the root system to aerial portions of transgenic plants by reducing the expression levels of HMA-related transporters. Various embodiments are directed to transgenic tobacco plants genetically modified to stably express a RNAi construct encoding RNAi polynucleotides that enable the degradation of endogenous NtHMA RNA variants. Reduced expression of NtHMA transporters in transgenic plants results in substantially reduced content of Cadmium (Cd) in the leaf lamina. Various consumable products that are substantially free or substantially reduced in Cd content can be produced by incorporating leaves derived from transgenic tobacco plants modified to reduce the expression of NtHMA transporters.
US08383887B2 Methods of using plants containing the gdhA gene
Disclosed are new effects of increased gdhA gene expression on plants that are susceptible to Aspergillus and Fusarium virguliforme infection. Plants transformed with the gdhA gene are resistant to aflatoxin accumulation following Aspergillus infection, and to root rot following F. virguliforme infection. The resistance to aflatoxin accumulation and root rot in gdhA+ plants is coincident with drought tolerance and resistance of the plants to certain herbicides. Methods for controlling aflatoxin contamination and root rot in crop plants, and for screening plants putatively transformed with gdhA, are described.
US08383885B1 Maize variety hybrid X00A926
A novel maize variety designated X00A926 and seed, plants and plant parts thereof, produced by crossing Pioneer Hi-Bred International, Inc. proprietary inbred maize varieties. Methods for producing a maize plant that comprises crossing hybrid maize variety X00A926 with another maize plant. Methods for producing a maize plant containing in its genetic material one or more traits introgressed into X00A926 through backcross conversion and/or transformation, and to the maize seed, plant and plant part produced thereby. This invention relates to the maize variety X00A926, the seed, the plant produced from the seed, and variants, mutants, and minor modifications of maize variety X00A926. This invention further relates to methods for producing maize varieties derived from maize variety X00A926.
US08383882B1 Maize variety hybrid X8N333
A novel maize variety designated X8N333 and seed, plants and plant parts thereof, produced by crossing Pioneer Hi-Bred International, Inc. proprietary inbred maize varieties. Methods for producing a maize plant that comprises crossing hybrid maize variety X8N333 with another maize plant. Methods for producing a maize plant containing in its genetic material one or more traits introgressed into X8N333 through backcross conversion and/or transformation, and to the maize seed, plant and plant part produced thereby. This invention relates to the maize variety X8N333, the seed, the plant produced from the seed, and variants, mutants, and minor modifications of maize variety X8N333. This invention further relates to methods for producing maize varieties derived from maize variety X8N333.
US08383881B2 Method for producing polyploid plants of orchids
A method for producing polyploid plants of orchids includes the steps of: providing a protocorm or protocom-like body (PLB) of an orchid, the protocorm or PLB having an upper portion with a growing point and a lower portion without any growing point; cutting the protocorm or PLB approximately at a point of half height to separate the upper portion; subculturing the lower portion of the protocorm or PLB in an inducing medium, and putting a cut surface of the lower portion of the protocorm or PLB to face upward so that one or more next-generation PLBs grow from the cut surface of the lower portion. The method characterized in using no antimicrotubule agent can simplify the entire process of orchid polyploidy breeding, and can be used in mass-production of the stable polyploid plants.
US08383880B2 Infertility control of genetically modified fish
A method of inducing male and/or female infertility in a genetically modified (GM) fish is disclosed. Also disclosed is a method of generating an infertile GM fish with a phenotype and/or genotype of interest. The method involves generation of a GM fish whose genome comprises a foreign transgene operably linked to a fish gonad-specific promoter selected from the group consisting of an ovary-specific promoter and a testis-specific promoter. The transgene comprises a suicide gene selected from the group consisting of a reductase and a photosensitizer, in which the reductase is operably linked to a reporter gene. Infertility of the GM fish is induced if the GM fish expressing the reductase is treated with an effective amount of a reductase-activated cytotoxic prodrug or if the GM fish expressing the photosensitizer is treated with light irradiation.
US08383878B2 Absorbent article having a multifunctional containment member
An absorbent article such as a diaper, training pant, and the like comprises a containment member that has a central zone and a barrier zone. The central zone has greater air flow according to the Air Permeability Test than the barrier zone. The barrier zone a greater hydrohead according to the Hydrostatic Head Pressure Test than the central zone. The containment member may be used for absorbent core formation and may have portions configured to serve as barrier leg cuffs for the finished absorbent article.
US08383877B2 Absorbent composites exhibiting stepped capacity behavior
An absorbent composite includes a water-insoluble fibrous matrix, a superabsorbent polymer composition that has an initial absorbent capacity of at least about 5 grams of saline per gram of superabsorbent polymer composition; and a first triggering mechanism having a first release time of between about 5 and 60 minutes, where the superabsorbent polymer composition has a second absorbent capacity that is at least about 25 % greater than the first absorbent capacity as measured by the mCRC Test.
US08383876B2 Absorbent articles with patterns of indicating
An absorbent article comprises a number of visual fullness indicating areas arranged in a distinct pattern. The pattern has an overall shape that is triangular or trapezoidal.
US08383875B2 Wetness indicator with hydrophanous element for an absorbent article
An absorbent article is provided for absorbing a liquid, the absorbent article including a chassis including a liner, an outer cover, and an absorbent structure positioned between the liner and the outer cover, the chassis including a front region and a back region, the front region and the back region defining a waist region therebetween. The absorbent article also includes a wetness indicator positioned adjacent the liner or the outer cover, the wetness indicator including a hydrophanous tissue layer having an absorbent-structure-facing side and being in liquid communication with the absorbent structure or the liner, and an indicator material disposed between the absorbent-facing side of the tissue layer and the absorbent structure. The absorbent article can also include a film layer disposed adjacent the tissue layer, and the indicator material can include an active constituent adapted to wick along the tissue layer when the absorbent article is insulted.
US08383871B1 Method of hydrogasification of biomass to methane with low depositable tars
Embodiments of a thermochemical method to convert lignocellulosic biomass to a useful fuel are disclosed in a process sequence resulting in low levels of depositable tars in the output gas stream. One disclosed embodiment comprises performing a sequence of steps at elevated pressure and elevated hydrogen partial pressure, including fast (or flash) hydropyrolysis of a lignocellulosic biomass feed followed sequentially with catalytically enhanced reactions for the formation of methane operating at moderate temperatures of from about 400° C. to about 650° C. and under moderately elevated pressure (about 5 atm to about 50 atm). A temperature rise in the catalyst above pyrolysis temperature is achieved without the addition of air or oxygen. Gas residence time at elevated temperature downstream of methane formation zones is extended well beyond the time required for methane formation. This sequence results in low depositable tars in the output gas stream.
US08383870B2 Environmentally friendly methods and systems of energy production
A process of energy production is disclosed. The process includes integrating three or more energy production technologies such that a first byproduct of a first energy production technology is applied to a second energy production technology and a second byproduct of the second energy production technology is applied to a third energy production technology. The process also includes operating the integrated energy production technologies to produce energy such that at least a portion of the first byproduct is utilized in an operation of the second energy production technology and a portion of the second byproduct is utilized in an operation of the third energy production technology.
US08383867B2 Method for producing fluorinated organic compounds
Disclosed is a method for producing fluorinated organic compounds, including hydrofluoropropenes, which preferably comprises converting at least one compound of formula (I): CF3CFnCHmXa-m  (I) to at least one compound of formula (II) CF3CZCHZ  (II). where each X is independently Cl, F, I or Br; each Z is independently H or F; n is 1 or 2; m is 1, 2 or 3, provided that when n is 1, m is 1 or 2; a is 2 or 3, and a-m≧0. Certain embodiments include the step of reacting fluorinated C2 olefin, such as tetrafluoroethylene, with a Cl addition agent under conditions effective to produce a compound of formula (I).
US08383863B2 Method for producing aldehyde and ketone
Provided is a highly efficient method for the production of aldehydes and ketones, which is inexpensive, exhibits high reactivity, and is capable of easy separation of byproduct after the reaction. More particularly, there is provided a method for producing an aldehyde or a ketone, comprising at least an oxidation step of oxidizing a primary alcohol or a secondary alcohol in the presence of a polymeric carbodiimide represented by the following formula (1) and having a weight-average molecular weight of 300 to 5000, and a sulfoxide compound, together with an acid and a base, or together with a salt of the acid and the base.
US08383862B2 Salt compound, cationic polymerization initiator and cationically polymerizable composition
Provided are a salt compound, cationic polymerization initiator and cationically polymerizable composition, which have a superior acid-generating capacity and high sensitivity, and are free from coloration. The salt compound is represented by the following general Formula (1): (wherein, R01 to R05 each independently represents a group selected from a hydrogen atom, a fluorine atom and —YR group, one of the R01 to R05 being a —YR group and at least two of the R01 to R05 being fluorine atoms; Y represents an oxygen atom or a sulfur atom; R represents a C1-C4 alkyl group; Ctp+ represents a p-valent cation, the p being 1 or 2; and n represents a coefficient required for maintaining electrical neutrality).
US08383861B2 Methods for making ethanolamine(s) and ethyleneamine(s) from ethylene oxide and ammonia, and related methods
The present invention relates to processes for the manufacture of one or more ethanolamines and one or more ethyleneamines starting from the reaction of ethylene oxide with ammonia to produce one or more ethanolamines and the conversion of the ethanolamine(s) to ethyleneamine(s). The present invention also relates to separating alkylethyleneamines from ethyleneamines.
US08383857B2 Processes for making hydrazides
A method is disclosed for preparing hydrazides from hydrazine and an acyl chloride which comprises the steps of (a) preparing a stirred substantially uniform slurry comprising hydrazine and an inert solvent at low temperature; and (b) adding an acyl chloride continuously to said slurry. The method avoids or limits production of undesired bis-hydrazide by-products. The method is used to prepare 3-methyl-3-mercaptobutanoic acid hydrazide, a molecule used to link calicheamicin to a monoclonal antibody.
US08383855B2 Histone deacetylase inhibitors
In recognition of the need to develop novel therapeutic agents, the present invention provides novel histone deacetylase inhibitors. These compounds include an ester bond making them sensitive to deactivation by esterases. Therefore, these compounds are particularly useful in the treatment of skin disorders. When the compounds reaches the bloodstream, an esterase or an enzyme with esterase activity cleaves the compound into biologically inactive fragments or fragments with greatly reduced activity Ideally these degradation products exhibit a short serum and/or systemic half-life and are eliminated rapidly. These compounds and pharmaceutical compositions thereof are particularly useful in treating cutaneous T-cell lymphoma, neurofibromatosis, psoriasis, hair loss, skin pigmentation, and dermatitis, for example. The present invention also provides methods for preparing compounds of the invention and intermediates thereto.
US08383849B2 Precursors for CVD silicon carbo-nitride films
Classes of liquid aminosilanes have been found which allow for the production of silicon carbo-nitride films of the general formula SixCyNz. These aminosilanes, in contrast, to some of the precursors employed heretofore, are liquid at room temperature and pressure allowing for convenient handling. In addition, the invention relates to a process for producing such films.The classes of compounds are generally represented by the formulas: and mixtures thereof, wherein R and R1 in the formulas represent aliphatic groups typically having from 2 to about 10 carbon atoms, e.g., alkyl, cycloalkyl with R and R1 in formula A also being combinable into a cyclic group, and R2 representing a single bond, (CH2)n, a ring, or SiH2.
US08383847B2 Process for the enrichment of methyl ricinoleate from castor oil methyl esters by liquid-liquid extraction
The present invention provides a process for the enrichment of methyl ricinoleate from castor oil methyl esters by liquid-liquid extraction (LLE) in presence of refined vegetable oils using an aqueous polar solvent. The invention provides an extraction of methyl ricinoleate by a non-destructive extraction method with good yields (75 to 90%) and purity (95 to 99%). The method consists of mixing castor oil methyl esters in a refined normal vegetable oil (feed) in a suitable proportion and selective extraction of methyl ricinoleate in a non-destructive manner by liquid-liquid extraction using a polar aqueous solvent, followed by de-solventization and drying of the solute to get enriched methyl ricinoleate fraction with good yields. The non-hydroxy fatty acid methyl esters of castor oil methyl esters are retained in the vegetable oil and can be used for the preparation of biodiesel or oelochemicals or reused in the process for the enrichment of methyl ricinoleate after removal of non-hydroxy fatty acid either by distillation under reduced pressure or further by liquid-liquid extraction using pure solvent.
US08383843B2 Method for preparing a coumarin compound, chromene compound, and method for preparing a chromene compound
Disclosed herein is a method for preparing a coumarin compound of formula (F), in which R1, R2, and R3 are independently H, C1˜C7 alkoxy, C1˜C7 alkyl, phenoxy, benzyloxy, or a halogen atom; R4 is an alkyl group; and Ar is an optionally substituted aryl group, the method including: treating a chromene compound having the following formula (E) with an acid in the presence of water. A chromene compound of formula (E) and a method for preparing the chromene compound of formula (E) are also disclosed.
US08383840B1 Extraction of fulvic minerals, vitamins, amino acids, enzymes, and phytonutrients from humic substances
The present invention provides a method for extracting fulvic minerals, vitamins, amino acids, enzymes, and phytonutrients from complexes of humic substances. The fulvic minerals, vitamins, amino acids, enzymes, and phytonutrients extracts are safe for human and animal consumption and for application to plant foliage. As a result of the extraction method, the fulvic minerals, vitamins, amino acids, enzymes, and phytonutrients extracts further comprise calcium and may comprise magnesium.
US08383837B2 Reaction with a gold catalyst
The invention relates to a process for the catalytic conversion of a carbohydrate, an alcohol, an aldehyde or a polyhydroxy compound in the presence of a catalyst containing gold in a solvent.
US08383835B2 Process for the production of cyclic diesters of alpha-hydroxyacids
Process for the synthesis of a cyclic diester of an alpha-hydroxyacid, comprising the following steps: an alkalino-earth salt of the corresponding alpha-hydroxyacid is mixed with said alpha-hydroxyacid and water; the mixture is treated by evaporation-crystallization, so that a hydrate of the alkalino-earth salt of the linear dimer of the corresponding alpha-hydroxyacid precipitates; the hydrated salt is dehydrated to give the corresponding anhydrous salt; and the anhydrous salt is pyrolyzed, releasing the cyclic diester of the corresponding alpha-hydroxyacid and leaving the alkalino-earth hydroxide as solid residue.
US08383832B2 Process for preparing benzimidazole compounds
Provided are methods for the synthesis of heterocyclic compounds such as benzimidazole carboxylic acid core structures having Formula Ib-1: wherein Z, X1, X2, X5, R2b and R10 are as defined herein. Compounds of Formula Ib-1 can be used to prepare heterocyclic derivatives such as benzimidazole derivatives.
US08383830B2 Cyanine compounds and their use in staining biological samples
Cyanine compounds having the general formula I for staining biological samples, wherein R1, R2, X, Y, A1 and A2 are as defined in the specification. These kinds of compounds may show good light illumination stability, have a maximum absorption peak around 640 nm that may not change as a function of ambient temperature, have rapidly increased fluorescence intensity upon binding to nucleic acids to form compound/nucleic acid complexes, and have a light spectrum in the near-infrared region, thereby effectively reducing interference from background fluorescence and increasing the accuracy of the detection when used as a staining agent for nucleic acids in a flow cytometer. The compounds provided can be used as a staining agent for erythroblasts in the blood.
US08383827B2 Aryl pyridine as aldosterone synthase inhibitors
The present invention provides a compound of formula I; a method for manufacturing the compounds of the invention, and its therapeutic uses. The present invention further provides a combination of pharmacologically active agents and a pharmaceutical composition.
US08383823B2 Substituted N-aryl pyridinones
Disclosed herein are substituted N-Aryl pyridinone fibrotic inhibitors and/or collagen infiltration modulators of Formula I, process of preparation thereof, pharmaceutical compositions thereof, and methods of use thereof.
US08383822B2 Substituted oxazolidinones and their use
The invention relates to novel substituted oxazolidinones, to processes for their preparation, to their use for the treatment and/or prophylaxis of diseases and their use for preparing medicaments for the treatment and/or prophylaxis of diseases, in particular of thromboembolic disorders.
US08383821B2 NK-1 and serotonin transporter inhibitors
The invention encompasses compounds of Formula I, including pharmaceutically acceptable salts, their pharmaceutical compositions, and their use in treating disorders associated with an excess or imbalance of tachykinins or serotonin or both.
US08383820B2 N-adamantyl benzamides as inhibitors of 11-β-hydroxysteroid dehydrogenase
Novel substituted benzamide based inhibitors, their use in therapy, pharmaceutical compositions comprising the compounds, the use of said compounds in the manufacture of medicaments, and therapeutic methods comprising the administration of said compounds are described. The present compounds modulate the activity of 11β-hydroxysteroid dehydrogenase type 1 (11βHSD1) and are accordingly useful in the treatment of diseases in which such a modulation is beneficial, such as the metabolic syndrome.
US08383818B2 Functionally selective alpha2C adrenoreceptor agonists
In its many embodiments, the present invention provides a novel class of heterocyclic derivatives as a2C adrenergic receptor agonists, methods of preparing such compounds, pharmaceutical compositions containing one or more such compounds, methods of preparing pharmceutical formulations comprising one or more such compounds, and methods of treatment, prevention, inhibition, or amelioration of one or more conditions associated with the a2C adrenergic receptors using such compounds or pharmaceutical compositions.
US08383817B2 Benztropine compounds and uses thereof
Disclosed are benztropine analogs having the formula (I) in which Ar is a C6-C20 monocyclic aryl group or a C10-C20 bicyclic aryl group or a heteroaryl, heterocyclic, or arylheterocyclic group having 2 to 12 carbon atoms and one or more heteroatoms selected from the group consisting of N, O, S, P, and any combination thereof; m=1 to 5; n=1 to 3; and R1 to R4 are as described in the specification; or a pharmaceutically acceptable salt or solvate thereof; pharmaceutical compositions and use thereof, e.g., in treating mental disorders.
US08383815B2 Heterogeneous ruthenium metal catalyst for the production of hydrocodone, hydromorphone or a derivative thereof
The present disclosure generally relates to catalytic methods for producing opioid derivatives. More particularly, the present disclosure relates to the preparation of hydrocodone, hydromorphone, or a derivative thereof, by means of a conversion or an isomerization of codeine, morphine, or a derivative thereof, respectively, using a heterogeneous ruthenium metal catalyst.
US08383814B2 Substituted tetrahydropyran spiro pyrrolidinone and piperidinone, preparation and therapeutic use thereof
The present disclosure relates to a series of substituted N-phenyl-bipyrrolidine carboxamides of formula (I): wherein R1, R2, m, n and p are as described herein. More specifically, the compounds of this invention are modulators of H3 receptors and are, therefore, useful as pharmaceutical agents, especially in the treatment and/or prevention of a variety of diseases modulated by H3 receptors including diseases associated with the central nervous system. Additionally, methods of preparation of substituted N-phenyl-bipyrrolidine carboxamides and intermediates therefore are disclosed.
US08383813B2 Fused pyrrolocarbazoles
The present invention relates generally to selected fused pyrrolocarbazoles, including pharmaceutical compositions thereof and methods of treating diseases therewith. The present invention is also directed to intermediates and processes for making these fused pyrrolocarbazoles.
US08383812B2 N-((1R,2S,5R)-5-(tert-butylamino)-2-((S)-3-(7-tert-butylpyrazolo[1,5-A][1,3,5]triazin-4-ylamino)-2-oxopyrrolidin-1-yl)cyclohexyl)acetamide, a dual modulator of chemokine receptor activity, crystalline forms and processes
The present invention provides a novel antagonist: N-((1R,2S,5R)-5-(tert-butylamino)-2-((S)-3-(7-tert-butylpyrazolo[1,5-a][1,3,5]triazin-4-ylamino)-2-oxopyrrolidin-1-yl)cyclohexyl)acetamide: or a pharmaceutically acceptable salt, solvate or prodrug, thereof, having unexpected dual CCR-2 and CCR-5 receptor activity. Crystalline forms, metabolites, pharmaceutical compositions containing the same and methods of using the same as agents for the treatment of inflammatory diseases, allergic, autoimmune, metabolic, cancer and/or cardiovascular diseases are also disclosed. The present disclosure also provides processes for preparing compounds of Formula (I) as provided herein, including N-((1R,2S,5R)-5-(tert-butylamino)-2-((S)-3-(7-tert-butylpyrazolo[1,5-a][1,3,5]triazin-4-ylamino)-2-oxopyrrolidin-1-yl)cyclohexyl)acetamide. Compounds that are useful intermediates of the process are also provided herein.
US08383809B2 Process for the preparation of drospirenone
A process for the preparation of Drospirenone (I) according to the scheme (A) wherein the substituent R is defined in the description. The process improves the product yield and purity by reducing the formation of undesired side-products and is particularly convenient for industrial-scale manufacturing.
US08383807B2 MicroRNA and methods for inhibiting same
The invention relates to isolated DNA or RNA molecules comprising at least ten contiguous bases having a sequence in a pancreatic islet microRNA. In another embodiment, the invention relates to isolated single stranded pancreatic islet microRNA molecules or anti-pancreatic islet microRNA molecules.
US08383805B2 RNAi modulation of SCAP and therapeutic uses thereof
The invention relates to a double-stranded ribonucleic acid (dsRNA) for inhibiting the expression of a SCAP gene (Human SCAP gene), comprising an antisense strand having a nucleotide sequence which is less that 30 nucleotides in length, generally 19-25 nucleotides in length, and which is substantially complementary to at least a part of a SCAP gene. The invention also relates to a pharmaceutical composition comprising the dsRNA together with a pharmaceutically acceptable carrier; methods for treating diseases caused by Human SCAP expression and the expression of a SCAP gene using the pharmaceutical composition; and methods for inhibiting the expression of a SCAP gene in a cell.
US08383799B2 Translocation and mutant ROS kinase in human non-small cell lung carcinoma
In accordance with the invention, a novel gene translocation, (4p15, 6q22), in human non-small cell lung carcinoma (NSCLC) that results in a fusion proteins combining part of Sodium-dependent Phosphate Transporter Isoform NaPi-3b protein (SLC34A2) with Proto-oncogene Tyrosine Protein Kinase ROS Precursor (ROS) kinase has now been identified. The SLC34A2-ROS fusion protein is anticipated to drive the proliferation and survival of a subgroup of NSCLC tumors. The invention therefore provides, in part, isolated polynucleotides and vectors encoding the disclosed mutant ROS kinase polypeptides, probes for detecting it, isolated mutant polypeptides, recombinant polypeptides, and reagents for detecting the fusion and truncated polypeptides. The disclosed identification of the new fusion protein enables new methods for determining the presence of these mutant ROS kinase polypeptides in a biological sample, methods for screening for compounds that inhibit the proteins, and methods for inhibiting the progression of a cancer characterized by the mutant polynucleotides or polypeptides, which are also provided by the invention.
US08383798B2 Polynucleotide encoding a cellulase enzyme and method for producing the enzyme
This invention provides: DNA encoding cellulase enzymes from intestinal symbiotic protists of the insects of Reticulitermes speratus, Hodotermopsis sjostedti, Neotermes koshunensis, Mastotermes darwiniensis, and Cryptocercidae, comprising the nucleotide sequences as shown in SEQ ID NOS:1 to 140; an expression system for the DNA; and a method for producing the cellulase enzymes using the expression system.
US08383794B2 Conformation-selective nucleic acid inhibitors of AMPA glutamate receptors
The present invention relates to novel nucleic acid ligands or aptamers that demonstrate potent and selective inhibition of the open-channel conformation of the α-amino-3-hydroxy-5-methyl-4-isoxazole propionate (AMPA) subtype of ionotropic glutamate receptors.
US08383789B2 Vasopressin-binding L-nucleic acid
The present invention relates to a vasopressin-binding nucleic acid, characterized in that the nucleic acid contains a stretch Box1 and a stretch Box2, in which Box1 comprises the sequence GUGGW and W=A or U, preferably W=U, and in which Box2 comprises a sequence of about 18 to 24 nucleotides, preferably 21 nucleotides, and a group (G)n is contained four times in the sequence, in which n=2, 3 or 4.
US08383787B2 Use of lipid conjugates in the treatment of diseases
This invention provides compounds represented by the structure of the general formula (A): wherein L is a lipid or a phospholipid, Z is either nothing, ethanolamine, serine, inositol, choline, or glycerol, Y is either nothing or a spacer group ranging in length from 2 to 30 atoms, X is a physiologically acceptable monomer, dimer, oligomer, or polymer, wherein X is a glycosaminoglycan; and n is a number from 1 to 1000, wherein any bond between L, Z, Y and X is either an amide or an esteric bond.
US08383782B2 Composite materials comprising supported porous gels
This invention relates to a composite material that comprises a support member that has a plurality of pores extending through the support member and, located in the pores of the support member, and filling the pores of the support member, a macroporous cross-linked gel. The invention also relates to a process for preparing the composite material described above, and to its use. The composite material is suitable, for example, for separation of substances, for example by filtration or adsorption, including chromatography, for use as a support in synthesis or for use as a support for cell growth.
US08383781B2 Anti-NIK antibodies and uses thereof
An antibody or antibody preparation being capable of specifically binding the amino acid sequence of NF-&kgr; B-inducing kinase (NIK) MAP3K14, or a specific portion thereof, and of thereby regulating a biochemical activity of NIK, and/or enabling detection of NIK or a specific portion thereof.
US08383780B2 Antibodies to TGFβ
The present invention relates to antibody molecules, in particular antibody molecules that bind Transforming Growth Factor beta (TGFβ), and uses thereof. More particularly, the invention relates to antibody molecules that bind and preferably neutralize TGFβ1, TGFβ2 and TGFβ3, so-called “pan-specific” antibody molecules, and uses of such antibody molecules. Preferred embodiments within the present invention are antibody molecules, whether whole antibody (e.g. IgG, such as IgG1 or IgG4) or antibody fragments (e.g. scFv, Fab, dAb).
US08383777B2 13-transmembrane protein expressed in prostate cancer
A novel prostate tumor associated gene (designated 24P4C12) and its encoded protein is described. 24P4C12 is highly expressed in prostate tissue xenografts, providing evidence that it is turned on in at least some prostate cancers. 24P4C12 provides a diagnostic and/or therapeutic target for prostate and other cancers.
US08383774B2 Collectin fusion proteins comprising TNF or trail
The present invention refers to a fusion protein comprising a TNF-superfamily (TNFSF) cytokine or a receptor binding domain thereof fused to a collectin trimerization domain, to a nucleic acid molecule encoding the fusion protein, and to a cell comprising the nucleic acid molecule. The fusion protein is present as a trimeric complex or as an oligomer thereof. The fusion protein, the nucleic acid, and the cell is suitable as pharmaceutical composition or for therapeutic, diagnostic and/or research applications.
US08383773B2 Protein product and method for reducing biomass-biomass interactions
The invention includes a process for extracting a target protein from Escherichia coli (E. coli) cells that includes lowering the pH of a whole E. coli cell solution to form an acidic solution, disrupting the cells to release the protein into the acidic solution, and separating the cellular debris from the released protein to obtain a protein product enriched in the heterologous target protein. The invention also includes addition of a solubility enhancer.
US08383768B2 CD133 epitopes
An immunogen includes an isolated peptide that includes the amino sequence of any one of SEQ ID NOs:1-21 with four or fewer amino acid substitutions.
US08383767B2 Immunogenic protein carrier containing an antigen presenting cell binding domain and a cysteine-rich domain
A protein carrier containing an antigen presenting cell binding domain and a cysteine-rich domain. Also described herein is an immunoconjugate containing the protein carrier with an antigen conjugated to multiple cysteine residues in the cysteine-rich domain, and an immune composition containing the immunoconjugate and an adjuvant, as well as their uses in eliciting immune responses.
US08383766B2 Position dependent recognition of GNN nucleotide triplets by zinc fingers
The specificity of binding of a zinc finger to a triplet or quadruplet nucleotide target subsite depends upon the location of the zinc finger in a multifinger protein and, hence, upon the location of its target subsite within a larger target sequence. The present disclosure provides zinc finger amino acid sequences for recognition of triplet target subsites having the nucleotide G in the 5′-most position of the subsite, that have been optimized with respect to the location of the subsite within the target site. Accordingly, the disclosure provides finger position-specific amino acid sequences for the recognition of GNN target subsites. This allows the construction of multi-finger zinc finger proteins with improved affinity and specificity for their target sequences, as well as enhanced biological activity.
US08383764B2 Method of purifying block copolymers
The invention relates to block polymers, for example, arborescent copolymer compounds, and to methods of making and purifying such compounds. In one embodiment, the invention relates to arborescent polymer compounds that contain one or more styrene polymeric blocks in combination with one or more isobutylene polymeric blocks. In another embodiment, the invention relates to methods for purifying arborescent polymer compounds that contain at least one styrene polymeric block in combination with at least one isobutylene polymeric block.
US08383763B2 ION-conducting sulfonated polymeric materials
Sulfonated polymers are made by the direct polymerization of a sulfonated monomer to form the sulfonated polymers. The types of sulfonated polymers may include polysulfones or polyimides. The sulfonated polymers can be formed into membranes that may be used in proton exchange membrane fuel cells or as ion exchange membranes. The membranes formed from the sulfonated polymers exhibit improved properties over that of Nafion®. A heteropoly acid may be added to the sulfonated polymer to form a nanocomposite membrane in which the heteropoly acid is highly dispersed. The addition of a heteropoly acid to the sulfonated polymer increases the thermal stability of the membrane, enhances the conductivity above 100° C., and reduces the water uptake of the membrane.
US08383761B2 Green to transmissive soluble electrochromic polymers
Green to transmissive soluble electrochromic polymers are conjugated polymers having a plurality of repeating units where repeating units are a plurality of substituted dioxyheterocycle based donor groups coupled to an acceptor group. The conjugated polymer absorbs radiation within a first band of the visible spectrum and a second band of the visible spectrum when in a neutral state resulting in a green color and is transmissive when in an oxidized state. The polymers are soluble allowing processing of films and coatings from solution.
US08383759B2 Method for producing liquid crystal polyester
A method is provided for producing a liquid crystal polyester including: (1) polycondensing a mixture of a compound of formula (I) with a compound of formula (II) in a polymerization tank at 260 to 350° C. to form a prepolymer, wherein a ratio of by-products to be distilled off to the theoretical amount of by-products formed when the compound of formula (I) is polycondensed with the compound of formula (II) in a stoichiometric relation is 95% or more; (2) continuously discharging the prepolymer from the polymerization tank in a molten state, solidifying the prepolymer while transferring, and continuously grinding the solidified prepolymer by a grinder provided downstream in a transfer direction to produce prepolymer particles; and (3) heat-treating the prepolymer particles in their solid state under an inert gas atmosphere, thereby subjecting them to solid phase polymerization.
US08383752B2 Method of making triglyceride macromonomers
A method of making a polymerisable ethylenically unsaturated macromonomer comprising the steps of: i) providing a chosen unsaturated non-mineral oil or a mixture of unsaturated non-mineral oils having a first blend of triglycerides, ii) treating the mixture of oils with a transesterification catalyst to produce a second blend of triglycerides different to the first, iii) reacting the second blend of triglycerides with an enophile having an acid, ester or anhydride moiety to form an adduct, iv) reacting the adduct with an ethylencially unsaturated monomer having a moiety reactive with the acid, ester or anhydride moiety of the enophile to form an intermediate, v) reacting the intermediate of step (iv) with a chain extender having at least two moieties reactive with the acid, ester or anhydride moiety of the enophile to form the ethylenically unsaturated macromonomer.
US08383751B2 High melt strength polystyrene and methods of making same
A method of making a styrenic composition having a high melt strength including combining a styrenic monomer and a second monomer to form a combined mixture and subjecting the combined mixture to polymerization to obtain a styrenic co-polymer, wherein the second monomer comprises a hydroxyl functional group and wherein the styrenic composition has a greater melt strength than that of general purpose polystyrene.
US08383749B2 Dry pigment preparations comprising non-ionic additives
The invention relates to a pigment preparation containing (i) at least one organic and/or inorganic pigment, (ii) a dispersant that can be obtained by the polmerization of monomers [A], [B], [C] and [D], where [A] is a monomer of formula (I) wherein A is C2-C4 alkylene and B is a C2-C4 alkylene different from A, and R is hydrogen or methyl, [B] is a monomer of formula (II) wherein D is C3 alkylene, R is hydrogen or methyl, and o is a number between 2 and 500, [C] is an ethylenically unsaturated monomer containing an aromatic group; and [D] is an ethylenically unsaturated monomer containing an alkyl radical.
US08383746B2 Water absorbing resin with improved internal structure and manufacturing method therefor
According to the present invention, the manufacturing method for the water absorbing resin involves the step of polymerizing a water-soluble unsaturated monomer, 0.06 of 5 mol % of which is composed of an internal crosslinking agent; and the step of drying a water-containing gel which has a thermally decomposing radical initiator content index of 40 to 100 at 100 to 250° C. The water absorbing resin of the present invention contains a water-soluble unsaturated monomer as a repeat unit for a major chain, 90 mol % of the monomer being composed of an acrylic acid and/or salt thereof, the resin having an internal crosslinking structure and exhibiting a weight-average molecular weight Mw of 360,000 to 1,000,000 daltons and an intrinsic viscosity IV of 2.1 to 6.0 dL/g where the weight-average molecular weight Mw and the intrinsic viscosity IV are measured after treatment under set 2 of hydrolysis conditions.
US08383745B2 Method for producing N-methyl-N-vinylacetamide having improved stability and polymerizability
The present invention relates to a method for producing N-methyl-N-vinylacetamide, which comprises a step for controlling the N-1,3-butadienyl-N-methylacetamide content in N-methyl-N-vinylacetamide to 0.01-150 ppm. This method enables production of N-methyl-N-vinylacetamide having a stable quality, which can be controlled in stability and polymerizability as a monomer. N-methyl-N-vinylacetamide produced by the method enables production of an N-methyl-N-vinylacetamide polymer having stable physical properties such as a molecular weight.
US08383744B2 Actinically-crosslinkable siloxane-containing copolymers
The invention provide a class of actinically-crosslinkable silicone-containing prepolymers which comprise dangling polysiloxane chains each having a terminal ethylenically-unsaturated group and are obtained in a one-step of RAFT polymerization of a reactive mixture comprising a polysiloxane crosslinker, a hydrophilic vinylic monomer, a RAFT agent, and a free-radical initiator. The present invention is also related to silicone hydrogel contact lenses made from a prepolymer of the invention and methods for making the contact lenses in a cost-effective way and with high consistency and high fidelity to the original lens design.
US08383743B2 Ink composition for jet printer
Disclosed is an ink composition for jet printer, comprising a pigment, a film forming resin and an organic solvent, the film forming resin being an acrylic copolymer containing, as a monomer unit, at least one of compounds represented by the general formulas (1) and (2): wherein R1 represents a hydrogen atom or a methyl group; R2 represents an alkylene group having 2 to 12 carbon atoms which may be linear or branched; and R3 and R4 each independently represents a hydrogen atom, an alkyl group, an alkenyl group or an aryl group, and the sum of the number of carbon atoms of R3 and R4 is from 4 to 12, or R3 and R4 form a saturated or unsaturated hydrocarbon group which is a five-membered ring formed by combination of the R3 and R4; and wherein R1 represents a hydrogen atom or a methyl group; R2 represents an alkylene group having 2 to 12 carbon atoms which may be linear or branched; and X represents a group selected from the group consisting of groups represented by the general formulas (3) to (9).
US08383742B2 Rubber composition and thermoplastic resin composition and production method thereof
The present application relates to a rubber composition containing a fluororubber, a radical initiator having a 1-minute half-life temperature of 280° C. or higher, and a crosslinking assistant having a melting point of 200° C. or higher and having two or more double bonds between carbon atoms; and a thermoplastic resin composition containing a fluororesin and the rubber composition.
US08383740B1 Horizontal agitator
The invention is an improved apparatus for continuously stirring polymer particles in reactive gas-filled polymerization reactors incorporating contiguous paddle stations on a coaxial drive shaft wherein the drive shaft is driven by a hydraulic motor.
US08383736B2 Method for preparation of polyolefins containing exo-olefin chain ends
The present invention is directed to a method for preparation of polyolefins containing exo-olefin chain ends. The method involves quenching a cationic quasi-living polyolefin polymer system with a nitrogen-containing five-membered aromatic ring having at least two hydrocarbyl substituent compounds attached to the ring.
US08383730B2 Bimodal polyethylene compositions for blow molding applications
Bimodal polyethylene compositions and methods for making the same are provided. In at least one specific embodiment, the bimodal polyethylene composition can include a high molecular weight component having a weight average molecular weight (Mw) of from about 400,000 to about 950,000. The bimodal polyethylene composition can also include a low molecular weight component having a weight average molecular weight (Mw) of from about 3,000 to about 100,000. The high molecular weight component can be present in an amount ranging from about 25 wt % to about 40 wt % of the bimodal polyethylene composition. The bimodal polyethylene composition can also have a percent die swell of less than about 80%.
US08383727B2 Adhesive and laminate using the same
Provided is a carbodiimide-modified, high-density polyolefin-based adhesive with minimal lowering of adhesion power even in a high temperature environment, and a laminate having excellent interlayer adhesion power at high temperatures prepared by using the adhesive.Provided is an adhesive obtained by reaction of a polyolefin (A) having a group reactive with a carbodiimide group and a compound (B) containing a carbodiimide group in the presence of an unmodified polyolefin (C), having a ratio of a peak intensity at 2130 to 2140 cm−1 to a peak intensity at 1470 cm−1 of 50% or less (but not including 0%).
US08383725B2 Polyester based degradable materials and implantable biomedical articles formed therefrom
A method of making an aliphatic polyester prepolymer, comprising: reacting, alone or in combination with other reactants, a diol with at least a first diacid (or a diester of said first diacid) to produce an aliphatic polyester prepolymer. The first diacid is preferably a trans-beta-hydromuconic acid (HMA). In some embodiments, the diol contains at least one ether linkage. In some embodiments the diol is further reacted with at a second diacid, or a diester of said second diacid, wherein said second diacid is different from said first diacid. Prepolymers produced from such processes and articles formed therefrom are also described.
US08383720B2 Thermoplastic composition
A thermoplastic resin composition comprising: 20 to 60 parts by mass of a styrene-based resin (A) in which a content of an unsaturated nitrile-based monomer is from 32 to 50 mass %; 20 to 60 parts by mass of an aromatic polyester (B) in which an isothermal crystallization time from the molten state is from 25 to 100 sec; and 20 to 60 parts by mass of a filler (C).
US08383719B2 Water-borne polyurethane coatings
Water-borne polyurethane coating compositions are provided. One exemplary water-borne coating composition includes a substantially water-free base component and an activator component. The substantially water-free base component includes at least a hydrophilic polyol, and the activator component includes at least a hydrophobic isocyanate.
US08383712B2 Plastic comprising zinc sulphide
The present invention relates to a plastic comprising zinc sulphide and to its use.
US08383710B2 Waterborne coating compositions containing low-VOC coalescents
Waterborne coating compositions are disclosed that include a latex emulsion polymer, and, as a coalescent, a levulinic acid ester of a monohydric aliphatic alcohol having from 10 to 20 carbon atoms. The coating compositions of the invention have a reduced VOC content, and provide improved coalescing activity compared with esters of polyols such as glycerol.
US08383708B2 Epoxidized soyate diesters and methods of using same
An unhindered polyol is used to react with an epoxidized soyate to make epoxidized soyate diester in the presence of a catalyst. The unhindered polyol can be 1,3-propanediol or any polyol having four or more carbon atoms with no two adjacent carbon atoms having hydroxyl functionality. Preferably, a combination of catalysts is used to promote the transesterification reaction of the epoxidized soyate with the unhindered polyol to yield a high percentage of epoxidized soyate diester with epoxy functionality retained. The primary catalyst is a metallic hydroxide, and the secondary catalyst is a titanate. Bioderived epoxidized soyate diester plasticizers useful for thermoplastics and thermosets result.
US08383704B2 Process for producing molded propylene polymer product containing fibrous inorganic filler
A molded propylene polymer product improved in flexural properties and/or impact resistance is prepared by a process comprising the steps of blending fibrous inorganic filler-containing pellets with a propylene polymer-containing matrix resin composition, in which the pellets comprises 35-80 wt. % of a fibrous inorganic filler, 1-45 wt. % of an olefin polymer, 5-45 wt. % of an elastomer, and 0.3-10.0 wt. % of a specific lubricant; kneading the blended product under molten condition; and molding the kneaded product.
US08383703B2 Making discrete solid particles of polymeric material
A process is provided for producing discrete solid beads of polymeric material e.g. phenolic resin having a mesoporous structure, which process may produce resin beads on an industrial scale without aggregates of resin building up speedily and interrupting production. The process comprises the steps of: (a) combining a stream of a polymerizable liquid precursor e.g. a novolac and hexamine as cross-linking agent dissolved in a first polar organic liquid e.g. ethylene glycol with a stream of a liquid suspension medium which is a second non-polar organic liquid with which the liquid precursor is substantially or completely immiscible e.g. transformer oil containing a drying oil; (b) mixing the combined stream to disperse the polymerizable liquid precursor as droplets in the suspension medium e.g. using an in-line static mixer; (c) allowing the droplets to polymerise in a laminar flow of the suspension medium so as to form discrete solid beads that cannot agglomerate; and (d) recovering the beads from the suspension medium. Also provided is an apparatus for forming discrete solid beads of polymeric material. In other embodiments, a method is provided for carbonizing and activating carbonaceous material, and an externally fired rotary kiln for carbonizing and activating carbonaceous material.
US08383697B2 Systems for self-healing composite materials
A composite material precursor composition includes a matrix precursor, a first plurality of capsules including a liquid polymerizer, an activator, and an accelerant. The liquid polymerizer polymerizes when in contact with the activator, and the accelerant is an accelerant for the polymerization of the liquid polymerizer. The composite material precursor may be used to form a composite material that includes a solid polymer matrix, the first plurality of capsules in the solid polymer matrix, the activator in the solid polymer matrix, and the accelerant in the solid polymer matrix.
US08383694B2 Polymerizable composition comprising perfluoropolyether material having ethylene oxide repeat unit segment
Presently is described a free-radically polymerizable composition comprising a mixture of reaction products of i) at least one polyisocyanate; ii) at least one isocyanate reactive perfluoropolyether compound; iii) at least one isocyanate reactive compound comprising greater than 6 repeat units of ethylene oxide; and iv) at least one isocyanate reactive non-fluorinated crosslinker comprising at least two free-radically polymerizable groups.
US08383693B2 Aerogel, and composition and method for manufacturing the aerogel
An aerogel including a polymeric reaction product of (a) a first monomer including an aromatic compound having at least two unsaturated functional groups, and (b) a second monomer represented by the following Chemical Formula 1 and including at least two groups independently chosen from (meth)acrylate groups and NR″R′ (where R″ and R′ are the same or different and are (meth)acryloyl groups) is provided. Each substituent is as defined in the specification.
US08383687B2 Microemulsion preparation of high concentration propofol for anesthetic uses
The invention provides a method and a composition for enhancing the dissolution and bioavailable properties of propofol (2, 6 diisopropyl phenol) for use as an intravenously administered anesthetic in mammals. The method produces a self-microemulsifiable emulsion base composition that is utilized in the production of a water-based microemulsion preparation. In a preferred two (2) component base composition, the base composition consists of: a surfactant, containing polyethylene glycol; and liquid propofol. The microemulsion is prepared by mixing the base composition with a carrier liquid, which results in the formation of a microemulsion containing concentrations of propofol of up to about 4% by weight of propofol to the volume of the microemulsion. In a four (4) component base composition, the base composition consists of: a surfactant, containing polyethylene glycol; liquid propofol; a water-immiscible solvent; and ethanol. The microemulsion is prepared by mixing the base composition with a carrier liquid, which results in the formation of a microemulsion containing concentrations of propofol of up to about 10% by weight of propofol to the volume of the microemulsion.
US08383669B2 Crystalline form of a 3-phenoxymethylpyrrolidine compound
The invention provides a crystalline hydrochloride salt of (S)-3-[(S)-1-(4-chlorophenoxy)-2-methylpropyl]pyrrolidine. This invention also provides pharmaceutical compositions comprising the crystalline salt, processes and intermediates for preparing the crystalline salt, and methods of using the crystalline salt to treat diseases.
US08383665B2 Immunomodulatory compositions
Isolated immunomodulatory (e.g. immunostimulatory) polyhydroxlated pyrrolizidine compounds having the formula are disclosed. In these compounds R is selected from hydrogen, straight or branched, unsubstituted or substituted, saturated or unsaturated acyl, alkyl (e.g. cycloalkyl), alkenyl, alkynyl and aryl groups. The compounds are useful in therapy and prophylaxis, including increasing the Th1:Th2 response ratio, hemorestoration, alleviation of immunosuppression, cytokine stimulation, treatment of proliferative disorders (e.g. cancer), vaccination, stimulation of the innate immune response and boosting of the activity of endogenous NK cells.
US08383663B2 Bendamustine anionic-catioinic cyclopolysaccharide compositions
The present invention is directed to pharmaceutical compositions including: (a) bendamustine, (b) a first charged cyclopolysaccharide, and (c) a stabilizing agent which is a second charged cyclopolysaccharide having a charge opposite to that of the first charged cyclopolysaccharide. The composition provides unexpectedly desirable stability in reactive environments such as plasma, coupled with unexpectedly desirable anticancer activity. The compositions are suitable for injection or infusion into patients in need for treatment with bendamustine.
US08383662B2 Bicyclic heteroaryl compounds
Bicyclic heteroaryl compounds of formula (I) shown below are disclosed. Each variable in formula (I) is defined in the specification. Also disclosed is treatment of cancer with these compounds.
US08383660B2 Dibenzyl amine compounds and derivatives
Dibenzyl amine compounds and derivatives of Formula I, pharmaceutical compositions containing such compounds and the use of such compounds to elevate certain plasma lipid levels, including high density lipoprotein-cholesterol and to lower certain other plasma lipid levels, such as LDL-cholesterol and triglycerides and accordingly to treat diseases which are exacerbated by low levels of HDL cholesterol and/or high levels of LDL-cholesterol and triglycerides, such as atherosclerosis and cardiovascular diseases in some mammals, including humans.
US08383659B2 Isoxazoline derivatives as pesticides
Novel isoxazoline compounds and compositions containing the compounds are disclosed. The compounds have pesticidal properties and are suitable for use on non-human animals.
US08383658B2 Isoxazole based neuronal nicotinic receptor ligands and methods of use
The invention relates to isoxazole derivatives, compositions comprising such compounds, and methods of preventing or treating conditions and disorders using such compounds and compositions.
US08383654B2 Heterocyclic antagonists of prostaglandin D2 receptors
Described herein are heteroaryl compounds that are antagonists of PGD2 receptors. Also described are pharmaceutical compositions and medicaments that include the heteroaryl compounds described. Also described herein are methods of using such antagonists of PGD2 receptors, alone and in combination with other compounds, for treating respiratory, cardiovascular, and other PGD2-dependent or PGD2-mediated conditions or diseases.
US08383646B2 Therapeutic ((bicylicheteroaryl)imidazolyl) methylheteroaryl compounds
Disclosed herein is a compound of the formula (I) therapeutic methods, compositions, and medicaments related thereto are also disclosed.
US08383644B2 Substituted azoanthracene derivatives, pharmaceutical compositions, and methods of use thereof
The present invention is directed to substituted azoanthracene derivatives or pharmaceutically acceptable salts thereof that modulate the human GLP-1 receptor and that may be useful in the treatment of diseases, disorders, or conditions in which modulation of the human GLP-1 receptor is beneficial, such as diabetes mellitus type 2. The invention is also directed to pharmaceutical compositions comprising these compounds and to the use of these compounds and compositions in the treatment of such diseases, disorders, or conditions in which modulation of the human GLP-1 receptor is beneficial.
US08383643B2 Spiro compounds useful as inhibitors of stearoyl-coenzyme A delta-9 desaturase
Heteroaromatic compounds of structural formula (I) are selective inhibitors of stearoyl-coenzyme A delta-9 desaturase (SCD1) relative to other known stearoyl-coenzyme A desaturases. The compounds of the present invention are useful for the prevention and treatment of conditions related to abnormal lipid synthesis and metabolism, including cardiovascular disease, such as atherosclerosis; obesity; diabetes; neurological disease; metabolic syndrome; insulin resistance; and liver steatosis.
US08383641B2 Aryloxyethylamine compounds suitable for treating disorders that respond to modulation of the dopamine D3 receptor
The present invention relates to aryloxyethylamine compounds of the formula I and the physiologically tolerated acid addition salts thereof. The variables have the meanings given in the claims and the description. The invention also relates to the use of a compound of the formula I or a pharmaceutically acceptable salt thereof for preparing a pharmaceutical composition for the treatment of a medical disorder susceptible to treatment with a dopamine D3 receptor ligand.
US08383640B2 Substituted pyrimidine ether compounds and use thereof
The invention relates to substituted pyrimidine ether compounds having general formula I: The groups are as defined as specification.The compounds of formula I show high insecticidal activities for imagoes, larvae and nits of harmful acari and insects in the agricultural, civil and zoic fields, especially show excellent insecticidal activities for harmful acari such as Tetranychus cinnabarinus. Good effects can be obtained at very low dose. The compounds also exhibit preferably fungicidal activity. Wherefore, the invention also comprises the uses of compounds of formula I as insecticides, acaricides and/or fungicides in agricultural and other fields.
US08383639B2 HIV integrase inhibitors
The disclosure generally relates to the novel compounds of formula I, including their salts, which inhibit HIV integrase and prevent viral integration into human DNA. This action makes the compounds useful for treating HIV infection and AIDS. The invention also encompasses pharmaceutical compositions and methods for treating those infected with HIV.
US08383638B2 Aminobenzoquinazolinone M1 receptor positive allosteric modulators
The present invention is directed to aminobenzoquinazolinone compounds of formula (I) which are M1 receptor positive allosteric modulators and that are useful in the treatment of diseases in which the M1 receptor is involved, such as Alzheimer's disease, schizophrenia, pain or sleep disorders. The invention is also directed to pharmaceutical compositions comprising the compounds, and to the use of the compounds and compositions in the treatment of diseases mediated by the M1 receptor.
US08383635B2 Chemical compounds
The invention is directed to pyrido[4,3-d]pyrimidin-5(6H)-one derivatives. Specifically, the invention is directed to compounds according to Formula I: wherein R1, R2, R3, and R4 are defined below. The compounds of the invention are inhibitors of PDK1 and can be useful in the treatment of disorders characterized by constitutively activated ACG kinases such as cancer and more specifically cancers of the breast, colon, and lung. Accordingly, the invention is further directed to pharmaceutical compositions comprising a compound of the invention. The invention is still further directed to methods of inhibiting PDK1 activity and treatment of disorders associated therewith using a compound of the invention or a pharmaceutical composition comprising a compound of the invention.
US08383633B2 Aminopyrimidines useful as kinase inhibitors
The present invention relates to compounds useful as inhibitors of Aurora protein kinases. The invention also provides pharmaceutically acceptable compositions comprising those compounds and methods of using the compounds and compositions in the treatment of various disease, conditions, and disorders. The invention also provides processes for preparing compounds of the invention.
US08383631B2 1,6-disubstituted-3-amino-4,5,6,7-tetrahydro-1H-pyrazolo[3,4-C]pyridin-7-one compounds and preparation thereof
Provided are a novel 1,6-disubstituted-4,5,6,7-tetrahydro-1H-pyrazolo[3,4-c]pyridin-7-one compound, a pharmaceutically acceptable salt compound thereof, a method for preparing the compound, and an anticancer pharmaceutical composition including the compound as an effective ingredient.
US08383627B2 Crystalline polymorph of doxazosin mesylate (form IV) and process for preparation thereof
Crystalline Form IV of doxazosin mesylate, a process for its preparation and uses thereof.
US08383621B2 Acylpiperazinones and their use as pharmaceuticals
The invention relates to novel acylpiperazinone compounds, to the preparation of the compounds and intermediates used therein, to the use of the compounds as antibacterial medicaments and pharmaceutical compositions containing the compounds.
US08383611B1 Ciclesonide containing aqueous pharmaceutical composition
The present invention provides an aqueous pharmaceutical composition containing ciclesonide and hydroxypropyl-methylcellulose, wherein the ciclesonide is dispersed in an aqueous medium in the form of solid particles. The composition is able to avoid variations in the concentrations of ciclesonide during production as well as avoid decreases in the recovery rate of ciclesonide.
US08383608B2 Imidazolidine compounds as androgen receptor modulators
Novel compounds are disclosed that have a Formula represented by the following: wherein X, R1, R2a, R2b, R2c, R3a R3b, R4a, R4b, R4c, and m1 are as described herein. The compounds may be prepared as pharmaceutical compositions, and may be used for the prevention and treatment of a variety of conditions in mammals including humans, including by way of non-limiting example, cachexia, osteoporosis, sarcopenia, a decline in libido and/or sexual dysfunction.
US08383602B2 Use of TRIM72 as a target for muscle and heart enhancer
The present invention relates to a new use of TRIM72 as a target for muscle enhancer and heart enhancer, more particularly to a composition for enhancing muscle or heart comprising an expression or action inhibitor of TRIM72 protein. The present invention further relates to a new TRIM mutant protein inducing muscle differentiation and hypertrophy and its gene. The inventors of the present invention have identified that TRIM72 overexpression inhibits myogenesis whereas TRIM72 knockdown enhances myogenesis, and first elucidated that TRIM72 is a negative regulator of skeletal muscle differentiation. Accordingly, the inhibition of TRIM72 acts exclusively on skeletal muscle and heart muscle, but does not affect IGF-I signaling pathway in other tissues. Therefore, a drug or gene therapy using TRIM72 as a target may be helpful in treating obesity and type 2 diabetes by promoting skeletal muscle differentiation, hypertrophy and energy consumption in adipose tissue and inducing strong muscle by promoting physiological hypertrophy of heart muscle, without cancer or other side effects.
US08383600B2 Increasing glucose transport and insulin-stimulated glucose uptake
Methods and compositions for modulating glucose transport are provided herein.
US08383599B2 Methods and compositions for RNA interference
The present invention provides methods for attenuating gene expression in a cell using gene-targeted double stranded RNA (dsRNA). The dsRNA contains a nucleotide sequence that hybridizes under physiologic conditions of the cell to the nucleotide sequence of at least a portion of the gene to be inhibited (the “target” gene).
US08383596B2 Antibacterial aminoglycoside analogs
Compounds having antibacterial activity are disclosed. The compounds have the following structure (I): including stereoisomers, pharmaceutically acceptable salts and prodrugs thereof, wherein Q1, Q2, Q3, R8 and R9 are as defined herein. Methods associated with preparation and use of such compounds, as well as pharmaceutical compositions comprising such compounds, are also disclosed.
US08383589B2 Aegyptin and uses thereof
The present invention relates to the discovery of the Aegyptin gene and Aegyptin protein, a molecule that interacts with collagen and inhibits platelet adhesion, activation and aggregation. Novel biological tools, prophylactics, therapeutics, diagnostics, and methods of use of the foregoing are also disclosed.
US08383587B2 Prevention of allergy at weaning
A nutritional composition comprising a partially hydrolysed milk protein having a degree of hydrolysis between 15 and 25% and 50 to 1000 nanograms of TGF-β per 100 ml of ready to consume composition and methods for the primary prevention of allergic reactions to newly introduced dietary protein at weaning and the prevention of development of atopic diseases in a young mammal at weaning comprising feeding to the young mammal a therapeutic amount of the composition are disclosed.
US08383585B2 Biomarkers for cardiodiabetes
The invention provides compositions and methods for determining cardiodiabetes status in a subject. The invention also provides compositions and methods for treating a subject experiencing cardiodiabetes.
US08383583B2 Macrocyclic, pyridazinone-containing hepatitis C serine protease inhibitors
The present invention relates to compounds of Formula I, II, or III, or pharmaceutically acceptable salts, esters, or prodrugs thereof: which inhibit serine protease activity, particularly the activity of hepatitis C virus (HCV) NS3-NS4A protease. Consequently, the compounds of the present invention interfere with the life cycle of the hepatitis C virus and are also useful as antiviral agents. The present invention further relates to pharmaceutical compositions comprising the aforementioned compounds for administration to a subject suffering from HCV infection. The invention also relates to methods of treating an HCV infection in a subject by administering a pharmaceutical composition comprising a compound of the present invention.
US08383580B2 Methods of administering lipocalins to treat metabolic disorders and cardiovascular diseases
A method of treating an LCN13-related condition is provided comprising administering to a patient in need thereof a therapeutically effective amount of a lipocalin or a physiologically active fragment thereof.
US08383576B2 LKKTET and/or LKKTNT peptide compositions which are lyophilized or in a form capable of being lyophilized
A composition including a peptide agent including amino acid sequence LKKTET [SEQ ID NO: 1] or LKKTNT [SEQ ID NO: 2], a conservative variant thereof, or a stimulating agent that stimulates production of an LKKTET [SEQ ID NO: 1] or LKKTNT [SEQ ID NO: 2] peptide, or a conservative variant thereof, the composition including at least one amino acid stabilizing agent or lyophilization bulking agent, the composition being in lyophilized form, or in a form capable of being lyophilized.
US08383571B2 Dual character polymer useful in fabric care products
New fabric care compositions including soil release polymers containing anionic substitution, nitrogen containing substitution, and alkoxy substitution are disclosed. In particular, fabric care compositions containing modified polysaccharides having anionic substitution, nitrogen containing substitution, and alkoxy substitution and methods of forming the same are disclosed.
US08383566B2 Highly acidic hard surface treatment compositions featuring good greasy soil and soap scum removal
Disclosed are aqueous, acidic hard surface cleaning compositions particularly effective in the removal of greasy stains and soapscum from hard surfaces. The compositions have a pH of not more than 2, preferably not more than 1, comprising: one or more anionic surfactants; a nonioinic surfactant constituent which preferably comprises both a first alcohol ethoxylate nonionic surfactant derived from monobranched alkoxylated C10-fatty alcohols and/or C11-fatty alcohols and about a second alcohol ethoxylate nonionic surfactant, preferably a C10-C14 linear alcohol ethoxylated surfactant having at least about 8 mols ethoxylation, an organic solvent constituent, which preferably comprises or consists of a phenyl containing glycol ether solvent, an acid constituent, which most preferably comprises, or consists of, a ternary acid system comprising each of: sulfamic acid, formic acid and oxalic acid in a respective weight ratio of sulfamic acid:formic acid:oxalic acid of 1-8:1-5:1-3. Methods for providing a cleaning treatment of hard surfaces utilizing the said compositions are also disclosed.
US08383565B2 Color changing paint and varnish remover
A color change paint and varnish removal formulation is provided. The formulation comprises: at least one penetrant, at least one water insoluble carrier and at least one color visible colorant whereby the formulation is applied to the target area and as the surface of the formulation dries, the penetrant migrates away from the dehydrating surface and a surface crust of beads is formed; the beads have a particle size that allows the scattering of visible light into white light and produces the whitening and dilution of the visible color and thus, there is a color change to indicate that the stripping action of the formulation has ceased and is ready for the scraping and removal step.
US08383563B2 Method for enhancing the oxidation and nitration resistance of natural gas engine oil compositions and such compositions
The resistance to oxidation and nitration of a gas engine oil is improved by the use of a combination of a hindered phenolic antioxidant and an (alkylated) phenyl-α-naphthylamine antioxidant. The additional use of an organo molybdenum compound further enhances the resistance to oxidation and nitration.
US08383562B2 System oil formulation for marine two-stroke engines
In one aspect of the present invention, a marine system oil composition is provided for lubrication of mechanical components in marine engines, for example, two-stroke, cross-head marine diesel engines and methods/additives for using the marine system oil composition in the same. In one aspect of the present invention, a marine system oil composition is provided that has salt of a carboxylate-containing detergent comprising at least one alkyl-substituted hydroxyaromatic carboxylic acid, wherein at least 50 mole % of, the alkyl groups are C20 or greater.
US08383561B2 Inert wear resistant PTFE-based solid lubricant nanocomposite
A PTFE-based composite material includes a PTFE major phase filled with a metal oxide minor phase. The major phase is intermixed with the metal oxide minor phase, wherein the minor phase includes a plurality of irregularly shaped metal oxide nanoparticles. The irregularly shaped nanoparticles provide substantial reductions in steady state wear rate over otherwise similar nanocomposites. The metal oxide can comprise aluminum oxide.
US08383560B2 Method of continuous dissolution of polyacrylamide emulsions for enhanced oil recovery (EOR)
Enhanced oil recovery method consisting in continuously dissolving, in the injection water, a stable invert emulsion of acrylamide (co)polymer containing at least one inverting agent, and a water soluble polymer, whereby: in a first step, the emulsion is prediluted in a first static mixer to a (co)polymer concentration of at least 5 g/l, the difference of pressure between the mixer outlet and inlet being at least 2 bar, in a second step, the suspension from the first mixer is diluted in a second static mixer to a concentration corresponding to the injection concentration of the water in the well of between 500 and 3000 ppm, the difference of pressure between the mixer outlet and inlet being at least 1 bar.
US08383557B2 Dual-functional breaker for hybrid fluids of viscoelastic surfactant and polymer
Incorporating water-based polymer breakers, such as oxidizers, enzymes and/or acids, into a mixture of an oil and oil-soluble surfactants creates an emulsion that can then perform as a dual-functional breaker for reducing the viscosity of hybrid fluids gelled with both a viscoelastic surfactant (VES) and a polymer. The outer phase of the dual-functional breaker emulsion is oil, e.g. a mineral oil, containing an oil-soluble surfactant that will, over time and with heat, break the VES portion of the gel. As it does so, the polymer breaker in the internal aqueous phase will be released to then break the polymer portion of the gel. The polymer breaker will not start to break the polymer gel before the oil-soluble surfactant starts to break the VES gel. The overall breaking using the emulsion is slower as compared to introducing the polymer breaker and the oil-soluble surfactant in a non-emulsified form.
US08383552B1 Flux pinning of cuprate superconductors with nanoparticles
The present invention provides a method of making a high temperature superconductor having a doped, nanoparticulate pinning structure. The method includes providing a nanoparticulate pinning material, providing a cuprate material, doping the nanoparticulate pinning material with a dopant to form a doped nanoparticulate material, depositing a layer of the cuprate material on a substrate, and depositing a layer of the doped nanoparticulate material on the layer of cuprate material. The invention also provides a high temperature superconductor (HTS) having a doped, nanoparticulate pinning structure including a plurality of layers of a cuprate material and a plurality of layers of a doped nanoparticulate pinning material. At least one layer of the doped nanoparticulate pinning material is stacked between two layers of the cuprate material.
US08383551B2 Thienodithiine derivatives
The present invention relates to new thienodithiine derivatives, to processes for preparing them, to their use for controlling unwanted microorganisms, more particularly phytopathogenic fungi, in crop protection, in the household and hygiene sector and in the protection of materials, and also to crop protection compositions comprising these thienodithiine derivatives.
US08383550B2 Defoliant
A mixture, comprising (A) thidiazuron (or thidiazuron and diuron), and (B) one or more compounds from the group of the herbicidal 1,2,4-triazinone, preferably metribuzin and/or metamitron, is suitable for use as a defoliant and/or a composition for reducing regrowth, in particular in crops of cotton.
US08383549B2 Methods of increasing crop yield and controlling the growth of weeds using a polymer composite film
Methods of protecting a crop from weed infestation, controlling weed growth, reducing fumigant dosage in crop protection, and reducing the growth of weeds by applying a polymer composite material with or without a biocide to soil, a crop, a vegetable, a weed, or combinations thereof are provided. In an aspect, the disclosure provides for a polymer composite material including a base polymer coated with: (1) a first barrier layer; (2) a second layer with our without a biocide; and (3) a third protective layer.
US08383544B2 Dual-stage method for the reactivation of thermally aged nitrogen oxide storage catalysts
Nitrogen oxide storage catalysts are used to remove the nitrogen oxides present in the lean exhaust gas of lean-burn engines. As a result of the stress due to high temperatures in vehicle operation, they are subject to thermal aging processes which affect both the nitrogen oxide storage components and the noble metals present as catalytically active components. The present invention provides a process with which the catalytic activity of a nitrogen oxide storage catalyst which comprises, in addition to platinum as a catalytically active component, basic compounds of strontium and/or barium on a support material comprising cerium oxide, said catalytic activity being lost owing to the thermal aging process, can be at least partly restored. The two-stage process is based on the fact that strontium and/or barium compounds formed during the thermal aging with the support material, which also comprise platinum, are recycled to the catalytically active forms by controlled treatment with specific gas mixtures.
US08383534B2 Process for producing aluminum magnesium titanate
The invention is to provide a process capable of producing aluminium magnesium titanate having a small coefficient of thermal expansion at a firing temperature lower than 1500° C. The production process of the invention comprises maintaining a pre-mixture containing a titania source powder, an alumina source powder, a magnesia source powder and a silica source powder within a temperature range of from 1100° C. to 1350° C. for at least 3 hours, followed by heating up to a temperature not lower than 1400° C. and firing at the temperature. The silica source powder is preferably a powder of alkali feldspar. Aluminium magnesium titanate is prepared according to the production process of the invention, and the resulting aluminium magnesium titanate is ground to give an aluminium magnesium titanate powder.
US08383532B2 Glass flake
The glass flake of the present invention has a composition that includes, in terms of mass %, 60
US08383520B2 Method of etching organosiloxane dielectric material and semiconductor device thereof
In some embodiments, a method of etching an organosiloxane dielectric material can include: (a) providing the organosiloxane dielectric material; (b) providing a patterned mask over the organosiloxane dielectric material; and (c) reactive ion etching the organosiloxane dielectric material. Other embodiments are disclosed in this application.
US08383519B2 Etching method and recording medium
An etching method by which a fluorine-added carbon film formed on a substrate is etched by plasma includes a first step of etching the fluorine-added carbon film with plasma of an oxygen-containing processing gas, and a second step of etching the fluorine-added carbon film with plasma of a fluorine-containing processing gas.
US08383517B2 Substrate processing method and substrate processing apparatus
A substrate processing method that can selectively remove deposit produced through dry etching of silicon. A substrate has a silicon base material and a hard mask that is made of a silicon nitride film and/or a silicon oxide film and formed on the silicon base material, the hard mask having an opening to which at least part of the silicon base material is exposed. A trench corresponding to the opening is formed in the silicon base material through dry etching using plasma produced from halogenated gas. After the dry etching, the substrate is heated to a temperature of not less than 200° C., and then hydrogen fluoride gas and helium gas are supplied toward the substrate.
US08383514B2 Method for stacking serially-connected integrated circuits and multi-chip device made from same
A multi-chip device and method of stacking a plurality substantially identical chips to produce the device are provided. The multi-chip device, or circuit, includes at least one through-chip via providing a parallel connection between signal pads from at least two chips, and at least one through-chip via providing a serial or daisy chain connection between signal pads from at least two chips. Common connection signal pads are arranged symmetrically about a center line of the chip with respect to duplicate common signal pads. Input signal pads are symmetrically disposed about the center line of the chip with respect to corresponding output signal pads. The chips in the stack are alternating flipped versions of the substantially identical chip to provide for this arrangement. At least one serial connection is provided between signal pads of stacked and flipped chips when more than two chips are stacked.
US08383508B2 Method for fabricating opening
The present invention provides a fabrication method of an opening. The method includes providing a substrate having a conductive region therein. Thereafter, a dielectric layer is formed over the substrate and then a stacked layer is formed on the dielectric layer. The stacked layer includes a patterned metal hard mask layer, a patterned silicon oxynitride layer and a patterned silicon oxide layer on the dielectric layer in sequence. Afterward, a first portion of the dielectric layer is removed using the stacked layer as a first mask to form a first opening that exposes a surface of the conductive region.
US08383507B2 Method for fabricating air gap interconnect structures
A metal interconnect structure includes at least a pair of metal lines, a cavity therebetween, and a dielectric metal-diffusion barrier layer located on at least one portion of walls of the cavity. After formation of a cavity between the pair of metal lines, the dielectric metal-diffusion barrier layer is formed on the exposed surfaces of the cavity. A dielectric material layer is formed above the pair of metal lines to encapsulate the cavity. The dielectric metal-diffusion barrier layer prevents diffusion of metal and impurities from one metal line to another metal line and vice versa, thereby preventing electrical shorts between the pair of metal lines.
US08383506B1 Method of forming a compliant monopolar micro device transfer head with silicon electrode
A compliant monopolar micro device transfer head array and method of forming a compliant monopolar micro device transfer array from an SOI substrate are described. In an embodiment, the micro device transfer head array including a base substrate and a patterned silicon layer over the base substrate. The patterned silicon layer may include a silicon interconnect and an array of silicon electrodes electrically connected with the silicon interconnect. Each silicon electrode includes a mesa structure protruding above the silicon interconnect, and each silicon electrode is deflectable into a cavity between the base substrate and the silicon electrode. A dielectric layer covers a top surface of each mesa structure.
US08383504B2 Method for providing electrical connections to spaced conductive lines
An integrated circuit and a method of formation provide a contact area formed at an angled end of at least one linearly extending conductive line. In an embodiment, conductive lines with contact landing pads are formed by patterning lines in a mask material, cutting at least one of the material lines to form an angle relative to the extending direction of the material lines, forming extensions from the angled end faces of the mask material, and patterning an underlying conductor by etching using said material lines and extension as a mask. In another embodiment, at least one conductive line is cut at an angle relative to the extending direction of the conductive line to produce an angled end face, and an electrical contact landing pad is formed in contact with the angled end face.
US08383498B2 Method for formation of tips
The present invention provides a method (80) for manufacturing a semiconductor tip. The method comprises obtaining (81) a substrate provided with a layer of tip material, providing (82) a doping profile in the layer of tip material, the doping profile comprising a tapered-shaped region of a first dopant concentration, undoped or lightly doped, e.g. having a dopant concentration of 1017 cm−3 or lower, surrounded by a region of a second dopant concentration, highly doped, e.g. having a dopant concentration above 1017 cm−3, the first dopant concentration being lower than the second dopant concentration, and isotropically etching (83) the layer of tip material by using an etch chemistry for which the etch rate of tip material with the second dopant concentration is substantially higher than the etch rate of the tip material with the first dopant concentration.
US08383494B2 Method for forming buffer layer for GaN single crystal
Disclosed is a method for forming a buffer layer for growing gallium nitride single crystals on a sapphire substrate using hydride vapor phase epitaxy (HVPE), wherein the buffer layer is formed in the form of a doped vertical gallium nitride (GaN) single crystal film with a nanoporosity of 0.10 to 0.15 μm on the sapphire substrate by reacting HCl and NH3 as a Group III/V mix gas.The nanoporous buffer layer interposed on the interface between the sapphire substrate and gallium nitride reduces tensile stress generated by the difference in thermal expansion coefficient between gallium nitride and the sapphire substrate, enables growth of the gallium nitride layer to a thickness of 1 micrometer (μm) to several millimeters (mm) without causing cracks, and reduces the lattice constant difference to improve crystallinity.
US08383493B2 Production of semiconductor devices
A method of producing a layered semiconductor device comprises the steps of: (a) providing a base comprising a plurality of semiconductor nano-structures, (b) growing a semiconductor material onto the nano-structures using an epitaxial 5 growth process, and (c) growing a layer of the semiconductor material using an epitaxial growth process.
US08383491B2 Method for manufacturing semiconductor substrate
A step of forming an insulating film over a semiconductor substrate and forming an embrittled region in the semiconductor substrate by irradiating the semiconductor substrate with accelerated ions through the insulating film; a step of disposing a surface of the semiconductor substrate and a surface of a base substrate opposite to each other and bonding the surface of the insulating film to the surface of the base substrate; a step of forming a semiconductor layer over the base substrate with the insulating film interposed therebetween by causing separation along the embrittled region by performing heat treatment after the surface of the insulating film and the surface of the base substrate are bonded to each other; a step of performing etching treatment on the semiconductor layer; a step of irradiating the semiconductor layer subjected to the etching treatment with a laser beam; and a step of irradiating the semiconductor layer irradiated with the laser beam with plasma.
US08383489B2 SOI wafer and method for forming the same
An SOI wafer and a method for forming the same, where the method for forming an SOI wafer includes: preparing a monocrystalline silicon wafer on which a mask layer is formed; etching the mask layer and the monocrystalline silicon wafer to form several trenches; forming a first insulating layer on the sidewalls and the bottoms of the trenches; etching and removing the first insulating layer on the bottoms of the trenches; etching along the trenches the monocrystalline silicon wafer beneath the trenches to form cavities; processing the inner walls of the cavities to form a second insulating layer; and filling up the trenches and the cavities with an insulating material layer. The process of the invention is easy to be implemented at a low manufacturing cost and an SOI wafer being formed is of high quality while being capable of being compatible with a standard process of manufacturing a bulk silicon CMOS.
US08383488B2 Method for producing a semiconductor component with two trenches
A method, in which a first isolating trench, filled with a dielectric material, and a second conducting trench, filled with an electrically conductive material, can be produced. To this end, the first and second trenches are etched with different trench widths, so that the first trench is filled completely with the dielectric material after a deposition of a dielectric layer over the entire surface with the edges covered, whereas the wider second trench is covered by the dielectric layer only on the inside walls. By anisotropic back-etching of the dielectric layer, the semiconductor substrate is exposed at the bottom of the second trench. Subsequently, the second trench is filled with an electrically conductive material and then represents a low-ohmic connection from the substrate surface to the buried structure located below the second trench.
US08383485B2 Epitaxial process for forming semiconductor devices
A method for forming a semiconductor device such as a MOSFET. The method includes forming gate electrode pillars on a silicon substrate via material deposition and etching. Following the etching step to define the pillars, an epitaxial silicon film is grown on the substrate between the pillars prior to forming recesses in the substrate for the source/drain regions of the transistor. The epitaxial silicon film compensates for substrate material that may be lost during formation of the gate electrode pillars, thereby producing source/drain recesses having a configuration amenable to be filled uniformly with silicon for later forming the source/drain regions in the substrate.
US08383478B2 High-density nonvolatile memory and methods of making the same
Nonvolatile memory cells and methods of forming the same are provided, the methods including forming a first conductor at a first height above a substrate; forming a first pillar-shaped semiconductor element above the first conductor, wherein the first pillar-shaped semiconductor element comprises a first heavily doped layer of a first conductivity type, a second lightly doped layer above and in contact with the first heavily doped layer, and a third heavily doped layer of a second conductivity type above and in contact with the second lightly doped layer, the second conductivity type opposite the first conductivity type; forming a first dielectric antifuse above the third heavily doped layer of the first pillar-shaped semiconductor element; and forming a second conductor above the first dielectric antifuse.
US08383476B2 EEPROM cell
A method of forming a device is disclosed. The method includes providing a substrate prepared with a cell area and forming first and second gates of first and second transistors in the cell area. The first gate includes a second sub-gate surrounding a first sub-gate. The first and second sub-gates of the first gate are separated by a first intergate dielectric layer. The second gate includes a second sub-gate surrounding a first sub-gate. The first and second sub-gates of the second gate are separated by a second intergate dielectric layer. The method also includes forming first and second junctions of the first and second transistors. A first gate terminal is formed and coupled to the second sub-gate of the first transistor. A second gate terminal is formed and coupled to at least the first sub-gate of the second transistor.
US08383472B2 Inverter, method of manufacturing the same, and logic circuit including the inverter
Provided are an inverter, a method of manufacturing the inverter, and a logic circuit including the inverter. The inverter may include a first transistor and a second transistor having different channel layer structures. A channel layer of the first transistor may include a lower layer and an upper layer, and a channel layer of the second transistor may be the same as one of the lower layer and the upper layer. At least one of the lower layer and the upper layer may be an oxide layer. The inverter may be an enhancement/depletion (E/D) mode inverter or a complementary inverter.
US08383468B2 Display device and manufacturing method thereof, and semiconductor device and manufacturing method thereof
A method of forming a display device including source/drain electrodes on a substrate, a pixel electrode, an insulating partition wall layer, a channel-region semiconductor layer. Source/drain electrodes of a thin-film transistor are formed on the substrate, while a pixel electrode is connected to the source/drain electrodes. The insulating partition wall layer is formed on the substrate, where the partition wall layer has a first opening extending to between the source electrode and the drain electrode. Furthermore, a channel-region semiconductor layer is formed by depositing a semiconductor layer over the partition wall layer. The channel-region semiconductor layer is on the bottom of the first opening to be separate from a upper part of the partition wall layer.
US08383460B1 Method for fabricating through substrate vias in semiconductor substrate
Methods are provided for fabricating integrated circuit systems that include forming integrated circuits in and on a semiconductor substrate. Via holes are etched into a front surface of the semiconductor substrate and are filled with a conductive material. A carrier wafer having a layer of adhesive thereon is provided and an imprinted pattern is formed in the layer of adhesive. The front surface of the semiconductor substrate is bonded to the carrier wafer with the patterned layer of adhesive. A portion of a back surface of the semiconductor substrate is removed to expose a portion of the conductive material and the thinned back surface is attached to a second substrate. The semiconductor substrate is then de-bonded from the carrier wafer.
US08383459B2 Methods of processing a thermal interface material
Methods are disclosed to process a thermal interface material to achieve easy pick and placement of the thermal interface material without lowering thermal performance of a completed semiconductor package. One method involves applying a non-adhesive layer on one or more surfaces of the thermal interface material, interfacing the thermal interface material with one or more components to interface the non-adhesive layer therebetween, and applying heat to alter the non-adhesive layer to increase thermal contact between the thermal interface material and the interfacing component(s).
US08383456B2 Semiconductor device and manufacturing method therefor
A multilayer wiring substrate has an upper surface with multiple bonding leads and a lower surface with multiple lands. Multiple wiring layers and insulating layers are alternately formed on the upper surface side and on the lower surface side of the core material of the wiring substrate. The bonding leads are formed of part of the uppermost wiring layer and the lands are formed of part of the lowermost wiring layer. The insulating layers include second insulating layers containing fiber and resin and third insulating layers smaller in fiber content than the second insulating layers. The second insulating layers are formed on the upper and lower surface sides of the core material. The third insulating layers are formed on the upper and lower surface sides of the core material with the second insulating layers in-between. The uppermost and lowermost wiring layers are formed over the third insulating layers.
US08383453B2 Method of manufacturing organic light emitting display apparatus and organic light emitting display apparatus
A method of manufacturing an organic light emitting display apparatus includes forming first electrodes on a substrate, forming a pixel defining layer (PDL) on the substrate and first electrodes, the PDL including openings exposing predetermined areas of the first electrodes, forming a charge transport layer on the PDL and inside the openings of the PDL, performing a hydrophobic process on the charge transport layer, performing a hydrophilic process on the charge transport layer, such that portions of the charge transport layer corresponding to the openings are made hydrophilic, forming organic light emitting layers on the charge transport layer, and forming a second electrode electrically connected to the organic light emitting layers.
US08383447B2 Reverse image sensor module and method for manufacturing the same
A reverse image sensor module includes first and second semiconductor chips, and first and second insulation layers. The first semiconductor chip includes a first semiconductor chip body having a first surface and a second surface facing away from the first surface, photodiodes disposed on the first surface, and a wiring layer disposed on the second surface and having wiring lines electrically connected to the photodiodes and bonding pads electrically connected to the wiring lines. The second semiconductor chip includes a second semiconductor chip body having a third surface facing the wiring layer, and through-electrodes electrically connected to the bonding pads and passing through the second semiconductor chip body. The first insulation layer is disposed on the wiring layer, and the second insulation layer is disposed on the third surface of the second semiconductor chip body facing the first insulation layer and is joined to the first insulation layer.
US08383446B2 Manufracturing method of solid-state imaging device
A solid-state imaging device includes: a photoelectric conversion portion that receives an incident light from a back surface side of a silicon layer to perform photoelectric conversion on the incident light; and a pixel transistor portion that outputs signal charges generated in the photoelectric conversion portion towards a front surface side of the silicon layer, wherein a gettering layer having internal stress is provided on the front surface side of the silicon layer at a position to overlap the photoelectric conversion portion on a plan view layout thereof.
US08383443B2 Non-uniform gate dielectric charge for pixel sensor cells and methods of manufacturing
A non-uniform gate dielectric charge for pixel sensor cells, e.g., CMOS optical imagers, and methods of manufacturing are provided. The method includes forming a gate dielectric on a substrate. The substrate includes a source/drain region and a photo cell collector region. The method further includes forming a non-uniform fixed charge distribution in the gate dielectric. The method further includes forming a gate structure on the gate dielectric.
US08383441B2 Method for manufacturing a micromachined device and the micromachined device made thereof
Methods for manufacturing micromachined devices and the devices obtained are disclosed. In one embodiment, the method comprises providing a structural layer comprising an amorphous semiconductor material, forming a shielding layer on a first portion of the structural layer and leaving exposed a second portion of the structural layer, and annealing the second portion using a first fluence. The method further comprises removing the shielding layer, and annealing the first portion and the second portion using a second fluence that is less than half the first fluence. In an embodiment, the device comprises a substrate layer, an underlying layer formed on the substrate layer, and a sacrificial layer formed on only a portion of the underlying layer. The device further comprises a structural layer that is in contact with the underlying layer and comprises a first region annealed using a first fluence and a second region annealed using a second fluence.
US08383437B2 Echtant and method for manufacturing display device using the same
An etchant according to exemplary embodiments of the present invention includes about 0.5 wt % to about 20 wt % of persulfate, about 0.01 wt % to about 2 wt % of a fluorine compound, about 1 wt % to about 10 wt % of inorganic acid, about 0.5 wt % to about 5 wt % of a cyclic amine compound, about 0.1 wt % to about 5 wt % of a chlorine compound, about 0.05 wt % to about 3 wt % of copper salt, about 0.1 wt % to about 10 wt % of organic acid or organic acid salt, and water.
US08383436B2 Manufacturing method for semiconductor chips, and semiconductor chip
By performing plasma etching on the second surface of a semiconductor wafer on the first surface of which an insulating film is placed in dividing regions and on the second surface of which a mask for defining the dividing regions are placed, the second surface being located opposite from the first surface, the insulating film is exposed from an etching bottom portion by removing portions that correspond to the dividing regions. Subsequently, by continuously performing the plasma etching in the state in which the exposed insulating film is surface charged with electric charge due to ions in the plasma, corner portions put in contact with the insulating film are removed in the device-formation-regions. Consequently, individualized semiconductor chips having a high transverse rupture strength are manufactured.
US08383433B2 Light emitting diode and method of fabricating the same
Exemplary embodiments of the present invention disclose a light emitting diode (LED) and a method of fabricating the same. The LED includes a substrate, a semiconductor stack arranged on the substrate, the semiconductor stack including an upper semiconductor layer having a first conductivity type, an active layer, and a lower semiconductor layer having a second conductivity type, isolation trenches separating the semiconductor stack into a plurality of regions, connectors disposed between the substrate and the semiconductor stack, the connectors electrically connecting the plurality of regions to one another, and a distributed Bragg reflector (DBR) having a multi-layered structure, the DBR disposed between the semiconductor stack and the connectors. The connectors are electrically connected to the semiconductor stack through the DBR, and portions of the DBR are disposed between the isolation trenches and the connectors.
US08383431B2 Organic light-emitting diode and method of manufacturing the same
An organic light emitting diode (OLED) including: a substrate; a reflection layer on the substrate and including metal; a first electrode on the reflection layer and including a light transparent aluminum zinc oxide (AZO); an organic layer on the first electrode and including an emitting layer; and a second electrode on the organic layer and including a semi-transparent reflection layer.
US08383430B2 Methods of combinatorial processing for screening multiple samples on a semiconductor substrate
In embodiments of the current invention, methods of combinatorial processing and a test chip for use in these methods are described. These methods and test chips enable the efficient development of materials, processes, and process sequence integration schemes for semiconductor manufacturing processes. In general, the methods simplify the processing sequence of forming devices or partially formed devices on a test chip such that the devices can be tested immediately after formation. The immediate testing allows for the high throughput testing of varied materials, processes, or process sequences on the test chip. The test chip has multiple site isolated regions where each of the regions is varied from one another and the test chip is designed to enable high throughput testing of the different regions.
US08383426B1 Double-masking technique for increasing fabrication yield in superconducting electronics
An improved microfabrication technique for Josephson junctions in superconducting integrated circuits, based on the use of a double-layer lithographic mask for partial anodization of the side-walls and base electrode of the junctions. The top layer of the mask is a resist material, and the bottom layer is a dielectric material chosen so to maximize adhesion between the resist and the underlying superconducting layer, be etch-compatible with the underlying superconducting layer, and be insoluble in the resist and anodization processing chemistries. The superconductor is preferably niobium, under a silicon dioxide layer, with a conventional photoresist or electron-beam resist as the top layer. This combination results in a substantial increase in the fabrication yield of high-density superconducting integrated circuits, increase in junction uniformity and reduction in defect density. A dry etch more compatible with microlithography may be employed.
US08383425B2 Method and compositions for the detection of protein glycosylation
The invention provides methods and compositions for the rapid and sensitive detection of post-translationally modified proteins, and particularly of those with post-translational glycosylations. The methods can be used to detect O-GlcNAc posttranslational modifications on proteins on which such modifications were undetectable using other techniques. In one embodiment, the method exploits the ability of an engineered mutant of β-1,4-galactosyltransferase to selectively transfer an unnatural ketone functionality onto O-GlcNAc glycosylated proteins. Once transferred, the ketone moiety serves as a versatile handle for the attachment of biotin, thereby enabling detection of the modified protein. The approach permits the rapid visualization of proteins that are at the limits of detection using traditional methods. Further, the preferred embodiments can be used for detection of certain disease states, such as cancer, Alzheimer's disease, neurodegeneration, cardiovascular disease, and diabetes.
US08383424B2 Methods for detection of cyclosporin A
Methods and reagents are disclosed for determining the presence and/or amount of cyclosporin A in a medium suspected of containing cyclosporin A. In the method a combination is provided in a medium. The combination comprises (i) the sample, (ii) a first member of a signal producing system (sps) associated with a first support wherein the first sps member is capable of activating a second member of the sps and wherein the first support is associated with a first member of a specific binding pair, and (iii) the second sps member associated with a second support wherein the second sps member is activatable by the first sps member. The second support comprises either (I) cyclosporin C or cyclosporin A and the combination further comprises a conjugate of an antibody for cyclosporin A and a second member of the specific binding pair or (II) antibody for cyclosporin A and the combination further comprises a conjugate of cyclosporin A and a second member of the specific binding pair. The combination is subjected to conditions for binding of cyclosporin A to the antibody for cyclosporin A. The first sps member is activated and the amount of signal generated by the second sps member is detected. The amount of signal is related to the presence and/or amount of cyclosporin A in the sample.
US08383423B2 Peptide-coated nanoparticles with graded shell compositions
A peptide-coated nanoparticle that includes a nanocrystal surrounded by a graded shell that is composed of at least two different semiconductor molecules. At least one peptide is attached to the surface of the graded shell to render the nanoparticle biocompatible. The nanocrystal core and graded shell are optionally annealed with ultra violet radiation prior to and/or after attachment of the peptide(s).
US08383422B2 Immunochromatographic device
The present invention provides an immunochromatographic device, which contains the following (a) and (b): (a) a first device part holding a first insoluble carrier used for developing a complex formed with an analyte and a labeling substance comprising a metal labeled with a first binding substance that can bind to the analyte and capturing the analyte and the labeling substance at a reaction portion containing a second binding substance that can bind to the analyte, and (b) a second device part holding a second insoluble carrier used for developing a liquid and a third insoluble carrier used for absorbing a liquid, in such a way that the first insoluble carrier does not come into contact with the second insoluble carrier and the third insoluble carrier.
US08383421B2 Cartridge for automatic measurement and measuring device using the same
An object of the present invention is to provide a cartridge for automatic measurement used in an automatic measuring device, capable of automatically performing measurement including heat treatment of a sample, and a measuring device using the cartridge.The present invention relates to a cartridge for use in measuring a component to be measured contained in a sample, comprising: at least a heat-treatment well for performing heat treatment of the sample; and a reaction well for reacting the component to be measured in the sample with a material specifically reacting therewith.
US08383418B2 Method for operating a tissue processor
A method for operating a tissue processor is described. During the operation of a tissue processor a reagent is fed from a container into a retort of the tissue processor, which retort does not contain any tissue samples. Thereafter, the reagent is returned into the container. During feeding, returning and/or in between feeding and returning a measured value is detected by a sensor of the tissue processor. This value is representative of a concentration of the reagent. During this feeding, this returning and/or in between no tissue sample is placed in the retort.
US08383406B2 Method for stimulating the proliferation of differentiated cells belonging to the chondrogenic lineage
A method for stimulating the proliferation of differentiated cells belonging to the chondrogenic lineage, includes the step of culturing the differentiated cells in a culture medium comprising glycylglycine in an amount sufficient to stimulate the proliferation of the cells.
US08383405B2 Methods of using ideotypically modulated pharmacoeffectors for selective cell treatment
In a method embodiment, a method includes introducing a plurality of Ideotypically Modulated Pharmacoeffectors (IMP) into a population of cells. Each IMP may include a detection domain and an activation domain. One or more epitopes is bound by the detection domain. The activation domain is activated in response to the binding. Applications may include but are not limited to viral infections, other intracellular infections, cancers, vector-borne diseases, autoimmune diseases, cellular diseases, cellular enhancement, and research.
US08383388B2 Modified coagulation factor IX polypeptides and use thereof for treatment
Provided are modified factor IX (FIX) polypeptides and methods of generating modified FIX polypeptides. Also provided are pharmaceutical compositions, including compositions formulation for oral administration, that contain the modified FIX polypeptides, and methods of treatment using modified FIX polypeptides.
US08383385B2 Variants of glycoside hydrolases
The present invention relates to variants of a parent glycoside hydrolase, comprising a substitution at one or more positions corresponding to positions 21, 94, 157, 205, 206, 247, 337, 350, 373, 383, 438, 455, 467, and 486 of amino acids 1 to 513 of SEQ ID NO: 2, and optionally further comprising a substitution at one or more positions corresponding to positions 8, 22, 41, 49, 57, 113, 193, 196, 226, 227, 246, 251, 255, 259, 301, 356, 371, 411, and 462 of amino acids 1 to 513 of SEQ ID NO: 2 a substitution at one or more positions corresponding to positions 8, 22, 41, 49, 57, 113, 193, 196, 226, 227, 246, 251, 255, 259, 301, 356, 371, 411, and 462 of amino acids 1 to 513 of SEQ ID NO: 2, wherein the variants have glycoside hydrolase activity. The present invention also relates to nucleotide sequences encoding the variant glycoside hydrolases and to nucleic acid constructs, vectors, and host cells comprising the nucleotide sequences.
US08383384B2 Polypeptide having glycosylation activity on a flavonoid
The present invention provides novel glycosyltransferase proteins produced by ascomycetous filamentous fungi (preferably species belonging to the genus Trichoderma, more preferably Trichoderma viride), as well as genes encoding the same. Among novel enzyme proteins provided by the present invention, particularly preferred is an enzyme protein obtained from the culture supernatant of Trichoderma viride strain IAM5141. The novel enzymes of the present invention allow glycosylation of flavonoid compounds to thereby improve their water solubility.
US08383383B2 Polypeptides having lipase activity and polynucleotides encoding same
The present invention relates to isolated polypeptides having lipase activity and isolated polynucleotides encoding the polypeptides. The invention also relates to nucleic acid constructs, vectors, and host cells comprising the polynucleotides as well as methods for producing and using the polypeptides.
US08383378B2 Micro-bubble plate for patterning biological and non-biological materials
Systems and methods are provided for patterning biological and non-biological material at specific sites on a plate, as well as growing three dimensional structures. Preferred embodiments comprise a plate with regions that will trap gas, usually in the form of bubbles, when the plate is submerged in liquid. Other embodiment of the present invention include a method for placing materials on the plate at pre-determined locations through the use of trapped gas to prevent materials from collecting at unwanted regions. The plate has great utility for plating cells and tissues at specific sites, such as on an array. The disclosed method can also be used to coat the surface of a plate with coatings at specific locations for patterned coating applications and to build up materials to produce three dimensional structures, including micro-mechanical structures—where the structures may be formed from living or non-living material, tissue or non-tissue, organic or inorganic, and the like.
US08383377B2 Bacterium capable of fermenting glucose, mannose and xylose simultaneously, and method for production of bioethanol using the bacterium
The object is to develop a bacterium capable of fermenting glucose, mannose and xylose simultaneously, which can ferment a saccharified solution of a cellulose-type or lignocellulose-type biomass resource to produce ethanol, and to construct an energy-saving high-efficiency bioethanol conversion process. Thus, disclosed is Zymomonas mobilis bacterium which is prepared by integrating a gene encoding a phosphomannose isomerase derived from Escharichia coli into a levansucrase gene located on the chromosome by the double cross-over by means of a homologous recombsination method, and then introducing recombinant DNA prepared by binding a DNA fragment containing genes encoding a xylose isomerase, a xylulokinase, a transaldolase and a transketolase, respectively, all derived from Escherichia coli to a vector. Also disclosed is a method for producing ethanol by continuously fermenting a saccharified solution of a cellulose-type biomass resource in a system on which the Zymomonas mobilis bacterium is immobilized.
US08383369B2 Intermittent detection during analytical reactions
Methods, devices, and systems for performing intermittent detection during analytical reactions are provided. Such methods facilitate collection of reaction data from disparate reaction times. Further, such methods are useful for reducing photo-induced damage of one or more reactants in an illuminated analytical reaction at a given reaction time. In preferred embodiments, the reaction mixture is subjected to at least one illuminated and non-illuminated period and allowed to proceed such that the time in which the reaction mixture is illuminated is less than a photo-induced damage threshold period.
US08383368B2 Method for fermentative production of N-acetyl-D-glucosamine by microorganism
N-Acetyl-D-glucosamine can be produced by cultivating a fungus capable of producing N-acetyl-D-glucosamine, such as Trichoderma hamatum AB 10282 strain (FERM BP-10623) or Trichoderma harzianum AB10283 strain (FERM BP-10624), in a culture medium supplemented with a carbon source other than chitin and chitin oligosaccharide and a nitrogen source to produce and accumulate N-acetyl-D-glucosamine in the culture medium and then collecting N-acetyl-D-glucosamine from the culture medium.
US08383367B2 IL-21 variant nucleic acids
IL-21 variants nucleic acid sequences are provided that encode a peptide having deletions and zero to ten conservative amino acid substitutions in the region of amino acid residues 65-96 of SEQ ID. NO:2.
US08383366B2 Enhanced protein expression in Bacillus
The present invention provides cells that have been genetically manipulated to have an altered capacity to produce expressed proteins. In particular, the present invention relates to Gram-positive microorganisms, such as Bacillus species having enhanced expression of a protein of interest, wherein one or more chromosomal genes have been inactivated, and preferably wherein one or more chromosomal genes have been deleted from the Bacillus chromosome. In some further embodiments, one or more indigenous chromosomal regions have been deleted from a corresponding wild-type Bacillus host chromosome.
US08383364B2 Inducible expression systems
Provided is an rtTA and single chain rtTA variants and uses thereof for inducible expression of a nucleic acid of interest. Nucleic acid molecules comprising an improved rtTA and/or sc rtTA sequence according to the invention are also provided, as well as vectors, replicons and cells comprising such nucleic acid molecules.
US08383361B2 Method for determining analyte concentration in biological fluid using electrochemical sensor
A polymer matrix that may coated on an electrode is created by co-crosslinking (1) an adduct of a polyaniline formed by templated oxidative polymerization on a polymer acid; (2) a water-soluble crosslinker; and (3) a redox enzyme. The polymer matrix may be hydrated, and the absorbed water may make it permeable to, for example, glucose. The polyaniline may be polyaniline itself or a substituted polyaniline; the water-soluble crosslinker may be poly(ethylene glycol)diglycidyl ether, and the redox enzyme may be glucose oxidase. The polymer matrix may be produced by co-crosslinking (1) an adduct of an electrically conductive polymer and a polymer acid; (2) a water-soluble crosslinker; and (3) a redox enzyme in a single step at an about neutral pH, curing by drying. After hydration, the crosslinked polymer matrix may form a 3-dimensional glucose-permeable bioelectrocatalyst, catalyzing the electrooxidation of glucose.
US08383359B2 Use of lymphocytes to measure anthrax lethal toxin activity
It is disclosed herein that isolated lymphocytes, such as human B-cells and CD4+ T-cell can be used to determine an amount of lymphocyte-associated anthrax lethal toxin activity present. Methods of using isolated lymphocytes to identify anthrax therapeutic agents and to determine the efficacy of a potential anthrax therapeutic are disclosed. Methods are also provided for diagnosing and treating anthrax infections.
US08383353B2 Method for in vitro detection and/or quantification and/or identification of infectious compounds in a biological material
Method for in vitro detection and/or quantification and/or identification of bacteria present in a fluid medium M constituting a biological material, in which method a suspension of microbeads of solid polymer material capable of binding proteins is prepared; the microbeads are loaded with β2GPI proteins; said loaded microbeads are brought into contact with the fluid medium M, in the presence of ions of an oxidizing metal, so as to bind the bacteria to the β2GPI proteins; the microbeads thus prepared are separated from their suspension medium, so as to obtain a residue; and the bacteria of the residue are detected and/or quantified and/or identified.
US08383352B2 Detection of maternal alcohol exposure
The present invention provides methods, compositions, and systems for detecting in utero alcohol exposure by detecting expression level changes in certain biomarkers (e.g., in placental tissue). In certain embodiments, the biomarkers are selected from glucocorticoid receptor (GR), thyroid hormone receptor alpha (TRα), iodothyronine deiodinase III (Dio3) and G-protein α-subunit (Gsα).
US08383351B2 Antibody to inhibin/ activin β-B subunit
The present invention provides an improved antibody specific for the inhibin/activin beta-B subunit polypeptide. The antibody is highly specific for the beta-B subunit in a sample, and does not require processing of the sample with heat or oxidizing agents. Thus, discovery of the new antibody provides for simpler, more accurate immunoassays for a wider range of sample types.
US08383350B1 Assay for detection of IL-10 antibodies
Provided are assays to measure the presence and quantity of an antibody of interest in a patient's bloodstream or other biological sample. ECL and ELISA methods, and kits for such assays, as well as anti-idiotypic antibodies provided to detect levels of the antibody in biological samples, which are from, for example, animal models and human patients.
US08383345B2 Sequence tag directed subassembly of short sequencing reads into long sequencing reads
The invention provides methods for preparing DNA sequencing libraries for assembling short read sequencing data into longer contiguous sequences and providing for genome assembly, full length cDNA sequencing, metagenomics, and the analysis of repetitive sequences of assembled genomes. The methods generally comprise incorporating adaptor or vector sequences into at least one member of a target fragment library, amplifying the population of target fragment library members to produce a plurality of copies of amplified DNA molecules, fragmenting the plurality of amplified DNA molecules, incorporating additional adaptor sequences, and amplifying a region of at least one of the plurality of amplified DNA molecules. At least one resulting amplicon comprises a sequence identical to or complementary to at least a portion of a sequence tag and a sequence identical to or complementary to a portion of a target fragment library member.
US08383344B2 Methods for quantification of microRNAs and small interfering RNAs
The invention relates to ribonucleic acids, probes and methods for detection, quantification as well as monitoring the expression of mature microRNAs and small interfering RNAs (siRNAs). The invention furthermore relates to methods for monitoring the expression of other non-coding RNAs, mRNA splice variants, as well as detecting and quantifying RNA editing, allelic variants of single transcripts, mutations, deletions, or duplications of particular exons in transcripts, e.g., alterations associated with human disease such as cancer. The invention furthermore relates to methods for detection, quantification as well as monitoring the expression of deoxy nucleic acids.
US08383342B2 Compositions, products, methods and systems to monitor water and other ecosystems
Disclosed are compositions, products, methods and systems for monitoring ecosystems, such as bodies of water, for a parameter of the ecosystems, such as the presence or absence of mercury. In one embodiment, the product may include a plurality of oligonucleotides immobilized at known locations on a substrate as an array, such that each location on the array is an oligonucleotide having a sequence derived from a single, predetermined operational taxonomic unit (OTU) and wherein at least one sequence on the array is associated with the presence or absence of mercury. The sequences immobilized on the array may be from known, or unknown organisms. Also disclosed are methods for identifying and isolating bioindicators diagnostic of ecosystem parameters, such as whether mercury is present. The compositions, products, methods and systems of the invention may be used for rapid, and continual monitoring of ecosystems for parameters of interest, such as the presence or absence of mercury.
US08383341B2 Method for non-invasive prenatal diagnosis
Method for non-invasive prenatal diagnosis comprising the following steps: a. obtain a sample of an organic fluid having a high probability of containing foetal cells from a pregnant woman; b. enrich said sample of organic fluid in at least one population of cells comprising at least one type of foetal nucleated cells; c. isolate at least one cell from among said at least one type of foetal nucleated cells; d. perform a genetic analysis on said at least one cell isolated from among said at least one type of foetal nucleated cells in order to highlight at least one genetic characteristic of said at least one foetal nucleated cell suitable for permitting said diagnosis; wherein the step of isolating at least one cell from among said at least one type of foetal nucleated cells is performed by individually selecting single cells in a microfluidic device designed for said purpose.
US08383340B2 Method for purifying RNA on a preparative scale by means of HPLC
The application describes a method for the preparative purification of RNA, which method is distinguished in that the RNA is purified by means of HPLC using a porous reversed phase as the stationary phase. The use of the porous reversed phase in this HPLC method is also described.
US08383335B2 Method for diagnosis and monitoring of viral infection by analysis of viral transrenal nucleic acids in urine
The present invention relates to methods for diagnosis or monitoring of viral infection by detecting the presence of transrenal viral nucleic acids or nucleic acids of viral origin in urine sample, with or without isolation of nucleic acids from a urine sample. The analysis of the nucleic acids is performed through hybridization of the nucleic acids with specific probes, or through a chain amplification reaction with specific primers. The methods are applicable to all viral pathogenic agents, including RNA, DNA, episomal, or integrated viruses.
US08383333B2 HBV precore protein capable of forming particles
There is provided a HBV precore protein having an ability of forming particles, and a means for determining it. A novel HBV precore protein that forms the virus (like) particles of HBV was identified. The present invention provides this novel HBV precore protein. Furthermore, there are provided core-like particles and virus-like particles formed by this HBV precore protein. These virus-like particles can be used for vaccines and therapeutic agents. The present invention also provides a method of determining the HBV precore protein and a method of determining the anti-HBV precore protein antibody.
US08383328B2 Method for producing optical part
A method for producing an optical part includes an irradiation process for irradiating a radiation-sensitive polymerizable composition with a radiation. The radiation-sensitive polymerizable composition includes at least a polymerizable compound (a) and a polymerizable or non-polymerizable component (c). The irradiation process includes at least a first step of irradiating with a radiation only a first irradiation region that is a portion of the radiation-sensitive polymerizable composition and a second step of irradiating with a radiation only a second irradiation region that is a portion of the radiation-sensitive polymerizable composition and is different from the first irradiation region in at least one of size and position. When the component (c) is polymerizable, the polymerization rate of the component (c) is controlled to be lower than that of the polymerizable compound (a) in the first and the second steps.
US08383326B2 Optical device and method of making the same using combination of light energy sensitive materials
A method of making optical devices includes applying an energy sensitive protective material and an energy sensitive advanced optical material to a surface. The surface can be on the optical device or on a carrier, such as a thin sheet, to be applied to the optical device. Light energy is applied through a special production filter to cure the energy sensitive protective material on the surface while blocking light energy outside a selected wavelength spectrum from reaching the material. A portion of the optical device can then be masked, and light energy outside the spectrum filtered by the special production filter can be applied to activate the unmasked portion of the advanced optical material. The special production filter allows curing of the protective material using light energy in a limited (e.g., visible) spectrum so that the advanced optical material can be activated using light energy in the ultraviolet spectrum.
US08383322B2 Immersion lithography watermark reduction
A method of performing immersion lithography on a semiconductor substrate includes providing a layer of resist onto a surface of the semiconductor substrate and exposing the resist layer using an immersion lithography exposure system. The immersion lithography exposure system utilizes a fluid during exposure and may be capable of removing some, but not all, of the fluid after exposure. After exposure, a treatment process is used to neutralize the effect of undesired elements that diffused into the resist layer during the immersion exposure. After treatment, a post-exposure bake and a development step are used.
US08383316B2 Resists for lithography
New routes involving multi-step reversible photo-chemical reactions using two-step techniques to provide non-linear resist for lithography are described in this disclosure. They may provide exposure quadratically dependant on the intensity of the light. Several specific examples, including but not limited to using nanocrystals, are also described. Combined with double patterning, these approaches may create sub-diffraction limit feature density.
US08383313B2 Toner
Provided is a toner including toner particles each containing a binder resin, a colorant, and a wax, and inorganic fine particles, the toner having such a characteristic that a temperature-storage elastic modulus curve at a high frequency shows a characteristic change in its behavior in a specific temperature region with respect to a temperature-storage elastic modulus curve at a low frequency.
US08383310B2 Toner compositions
The present disclosure relates to a binder resin system suitable for use in forming toner compositions. In embodiments, the binder resin system includes at least one amorphous resin, at least one crystalline resin, and at least one fatty acid salt. The presence of the fatty acid salt reduces plasticization which may otherwise occur upon combining the amorphous and crystalline resins, thereby increasing the glass transition temperature of the binder resin, as well as any toner produced with such binder resin. Toners produced with the disclosed binder resin may also include one or more optional ingredients such as optional colorants, optional waxes, and combinations thereof.
US08383304B2 Gallium phthalocyanine compound, and image bearing member, image forming method, image forming apparatus, and process cartridge using the gallium phthalocyanine compound
A gallium phthalocyanine compound represented by the following chemical structure I, where X represents a substituted or non-substituted alkyl group, a substituted or non-substituted alkenyl group, a substituted or non-substituted alkynyl group, a substituted or non-substituted aralkyl group, a substituted or non-substituted cycloalkyl group, a substituted or non-substituted aryl group, or a hydrogen atom, where substitution groups thereof are an alkoxy group, an alkylthio group, an alkyl group, a halogen atom, nitro group, amino group, an aryl group, carboxylic group, and cyano group, R1 to R16 independently represent a hydrogen atom, an alkoxy group, an alkylthio group, an alkyl group, a halogen atom, nitro group, or aryl group, n represents an integer of from 1 to 3 but excluding a combination in which n is 1 and X is methyl group.
US08383298B2 Substrate processing method, manufacturing method of EUV mask, and EUV mask
According to the substrate processing method in the embodiments, as a mask substrate used for forming an EUV mask, a mask substrate in which a first film having a first hydrophilicity is formed on one main surface and a resist is applied to another main surface is exposed from a side of the resist. Then, a hydrophilic treatment is performed on a surface of the first film to make the surface of the first film have a second hydrophilicity larger than the first hydrophilicity. Then, a development treatment of the resist is performed with respect to the mask substrate in which the hydrophilic treatment is performed on the surface of the first film to have the second hydrophilicity.
US08383292B2 Fuel cell
In a fuel cell that includes an electrolyte (10), and an anode (20) and a cathode (30) which constitute a pair of electrodes that are arranged sandwiching the electrolyte (10), the cathode (30) includes catalyst particles (24) and trapping particles (38). The catalyst particles (24) operate as catalysts for a reaction that creates hydroxide ions from oxygen, and the trapping particles (38) trap hydrogen peroxide ions.
US08383289B2 Electronics cabinet with air feed system for backup power fuel cell
An air feed system for a fuel cell cabinet is provided. The air feed system supplies temperature controlled air to a fuel cell. The air feed system includes a controller that controls the air feed system for maintaining a predetermined temperature range of the temperature controlled air entering the fuel cell.
US08383285B2 Gas diffusion unit
A gas diffusion unit for a fuel cell, having at least two planar gas diffusion layers on whose edges seals are configured, at least two gas diffusion layers being joined together in an articulated manner.
US08383269B2 Negative-limited lithium-ion battery
A rechargeable lithium-ion battery includes a positive electrode having a first capacity and a negative electrode having a second capacity that is less than the first capacity such that the battery has a negative-limited design. The negative electrode includes a lithium titanate active material. A liquid electrolyte that includes a lithium salt dissolved in at least one non-aqueous solvent a porous polymeric separator are located between the positive electrode and negative electrode. The separator is configured to allow lithium ions to flow through the separator.
US08383266B2 Zirconium oxide and method for the production thereof
The invention relates to a pulverulent zirconium oxide containing metal oxides from the group consisting of scandium, yttrium, rare earths and mixtures thereof, processes for producing them and their use in fuel cells, in particular for the production of electrolyte substrates for ceramic fuel cells.
US08383261B2 Film-packaged electric device
To provide a film-packaged battery 1 in which battery element 2 formed by collectively joining a plurality of positive and negative extending portions 2a and 2b to positive and negative electrode leads 3a and 3b for each polarity, is surrounded by laminate films 5 and 6 which are formed by laminating at least heat fusion layer 10 and metal layer 11. Protection member 4a having a melting point lower than that of heat fusion layer 10 is arranged at least between each of joining portions 20a and 20b of positive and negative electrode extending portions 2a and 2b, and heat fusion layer 10 of laminate film 5 which layer face the each of joining portions 20a and 20b.
US08383259B2 Safety device for an accumulator cell
In the case of a safety device for an accumulator cell, which has an electrode assembly disposed in an elastic cell sheath and at least one electrical connector, a blocking element is provided which blocks at least a first electrical contact associated with the electrical connector with at least a second electrical contact in a releasable electrical connection, the blocking element being configured for the purpose of releasing the releasable electrical connection when the cell sheath expands as a result of a change in volume of the accumulator cell during operation. A separation of the second contact from the first contact is thereby made possible.
US08383255B2 Closure assembly for electrochemical cells
An end assembly seals a cylindrical electrochemical cell. The assembly includes a positive temperature coefficient (PTC) device and a gasket having a protrusion that cooperates with the end assembly isolates the PTC device from primary axial compression forces present in the closure assembly. In further embodiments of the present invention, the end assembly may be produced by insert molding a seal element about the terminal cover and the gasket itself has an E or F shaped cross section.
US08383251B2 Substituted pyrenes and associated production methods for luminescent applications
A substituted pyrene for electroluminescent applications and a method to produce the substituted pyrenes.
US08383250B2 Light-emitting element, light-emitting apparatus, display apparatus, and electronic device
A light-emitting element includes a cathode, an anode, a red-light-emitting layer that is disposed between the cathode and the anode and emits red light, a blue-light-emitting layer that is disposed between the red-light-emitting layer and the cathode and emits blue light, a green-light-emitting layer that is disposed between the blue-light-emitting layer and the cathode and emits green light, and an intermediate layer that is disposed between and in contact with the red-light-emitting layer and the blue-light-emitting layer and functions so as to control the transfer of positive holes and electrons between the red-light-emitting layer and the blue-light-emitting layer, wherein the intermediate layer contains a first material and a second material different from the first material, the red-light-emitting layer contains a material of the same type as the first material, and each of the blue-light-emitting layer and the green-light-emitting layer contains a material of the same type as the second material.
US08383249B2 Complexes with tridentate ligands
The present invention relates to organic light emitting devices (OLEDs), and more specifically to phosphorescent organic materials used in such devices. More specifically, the present invention relates to emissive phosphorescent material which comprise at least one tridentate ligand bound to a metal center, wherein at least one of the bonds to the tridentate ligand is a carbon-metal bond.
US08383248B2 Coated article
A coated article is described. The coated article includes a substrate, a combining layer formed on the substrate, a plurality of titanium dioxide layers and a plurality of copper-zinc alloy layers formed on the combining layer. The combining layer is a titanium layer. Each titanium dioxide layer interleaves with one copper-zinc alloy layer. A method for making the coated article is also described.
US08383247B2 Lightweight composite article with controlled biodegradation
A lightweight composite article with controlled biodegradation includes a fibrous substrate and one or more additives applied to the fibrous substrate to control the rate of biodegradation of the composite article. The composite article has a weight of less than about 57 grams per square meter, and a biodegradation within a range of from about 30 days to about 150 days. In some embodiments, the additives include one or more of water repellent, antimicrobial agent and biodegradable binder.
US08383245B2 Gas barrier multilayer structure precursor,gas barrier multilayer structure and processes for producing the same
Gas barrier multilayer structure precursors are not clouded even when exposed to cold water and have excellent abuse resistance. Gas barrier multilayer structures are obtained from the gas barrier multilayer structure precursors.A gas barrier multilayer structure precursor includes a support and a gas barrier layer precursor formed on the support, the gas barrier layer precursor including a layer (A) and a layer (B), the layer (A) including a polycarboxylic acid polymer and a silicon-containing compound (i) derived from a silane coupling agent represented by Formula (1) below, the weight ratio of the polycarboxylic acid polymer and the silicon-containing compound (i) being in the range of 99.5:0.5 to 80.0:20.0, the layer (B) including a polyvalent metal compound, the layer (A) analyzed by a transmission method showing an infrared absorption spectrum in which the maximum peak height (α) in the range of 1490 to 1659 cm−1 and the maximum peak height (β) in the range of 1660 to 1750 cm−1 have a ratio (α/β) of less than 1. A gas barrier multilayer structure is obtained by subjecting the gas barrier multilayer structure precursor to retort treatment, boil treatment or humidity conditioning treatment. Si(OR)3Z  (1)
US08383244B2 Semiaromatic molding compounds and uses thereof
Disclosed is a polyamide molding compound having heat aging resistance for use as automobile or electrical components and composed of: (A) 27-84.99 wt % of a polyamide mixture consisting of (A1) at least one semiaromatic, semicrystalline polyamide having a melting point of 255° C. to 330° C., (A2) at least one caprolactam-containing polyamide that is different from (A1) and that has a caprolactam content of at least 50 wt %, where the total caprolactam content is 22-30 wt %, with respect to the polyamide mixture, (B) 15-65 wt % of at least one filler and reinforcing agent, (C) 0.01-3.0 wt % of at least one thermal stabilizer, and (D) 0-5.0 wt % of at least one additive, where the components (A)-(D) add up to 100 wt %.
US08383237B2 Preparation of silica stabilized biological templates for the production of metal and layered nanoparticles
The present invention relates to a system and method providing for increased silica growth on a bio-template, wherein the bio-template is pretreated with aniline to produce a uniform silica attractive surface and yielding a significant silica layers of at least 10 nm, and more preferably at least 20 nm in thickness, thereby providing for a high degree of stability to the bio-template.
US08383236B2 Zirconia sintered body and production method the same
Provided are a zirconia sintered body that has excellent mechanical characteristics, as well as semiconductivity that can allow static electricity to escape at an appropriate rate, and a manufacturing method that can manufacture the same at lower cost than in the past. The zirconia sintered body is made of 66-90 parts by weight of zirconia that contains a stabilizer, and a total of 10-34 parts by weight of iron, chromium and titanium oxides. Of the iron, chromium and titanium oxides, the proportion of iron oxide is 70-99.5 wt %, the proportion of chromium oxide is 0.4-20 wt % and the proportion of titanium oxide is 0.1-10 wt %. The combined proportion of tetragonal and cubic crystals in the zirconia crystal phase is 90% or more and the mean crystal grain size of the zirconia is 0.3-0.5 μm. The mean crystal grain size of the iron, chromium and titanium oxides is 0.5-2.0 μm. It has excellent mechanical characteristics, as well as semiconductivity.
US08383235B2 Fibrous structures
Fibrous structures that exhibit a Dry Burst of greater than 100 g and a Cross-Machine Direction Flexural Rigidity (CD Flexural Rigidity) of greater than 56 mg*cm2/cm as measured according to the Flexural Rigidity Test Method and/or a Total Dry Tensile (TT or TDT) of less than 3000 g/76.2 mm as measured according to the Tensile Strength Test Method and/or a Geometric Mean Tensile (GM Tensile or GMT) of less than 750 g/76.2 mm as measured according to the Tensile Strength Test Method and/or a Machine Direction Modulus (MD Modulus) of less than 900 g/cm as measured according to the Modulus Test Method are provided.
US08383233B2 Ceiling tile base mat
A water felted base mat for a suspended ceiling tile comprising on a weight basis about ½ mineral wool, starch binder, limited to about ⅛, newsprint, limited to about ⅛, and about ¼ expanded glass beads.
US08383232B2 Foamboard substrate for use with digital imaging systems
A printing substrate is provided, wherein the printing substrate includes a top layer; a middle layer, wherein the middle layer is attached to the top layer, and wherein the middle layer further includes a material that is different than the material of the top layer; and a bottom layer, wherein the bottom layer is attached to the middle layer, and wherein the bottom layer further includes a material that is different than the material of the middle layer and a material that is the same as the material of the top layer; and wherein the printing substrate is adapted specifically for use with use with digital imaging systems such as large, flatbed digital printers and the like.
US08383229B2 Protective pad for use during athletic activities
A protective pad to be employed by a person engaged in athletic activity utilizes to protect the user's hands formed from a very thin rectangular piece of rubber having a thickness of approximately 0.032 inch. On the top side of the protective pad are located treads upraised from the top surface of the pad. The treads are evenly spaced and approximately ½ inch apart and have triangular cross sections. The bottom side of the protective, which is the side placed against the grip portion of the piece of athletic equipment, is generally flat and has a tacky surface. The user wraps the protective pad around the grip portion of the piece of athletic equipment with the bottom tacky side of the pad adjacent to the grip.
US08383227B2 Transfer layer for absorbent article
A composite particularly suited for use as a transfer layer in an absorbent article has a first layer comprising a formed film having a plurality of capillary-sized apertured protuberances and a plurality of two-dimensional drains, and a second layer in intimate contact with an apertured end of said capillary-sized protuberances and spaced from the first layer in a z-direction, the second layer is either a three-dimensional apertured formed film or a nonwoven web. In embodiments where the second layer is a three-dimensional formed film, the film contains a plurality of capillary sized protuberances that are of smaller diameter compared to the protuberances in the first layer and optionally also contains a plurality of drains, which can be either two-dimensional or three-dimensional, or combinations thereof.
US08383222B2 Self-laminating card and assembly
A self-laminating assembly for providing information, such as emergency medical or contact information, or a temporary identification card, for general purposes. Medical data or contact information is entered on a card which is predisposed within the assembly. The card can then be covered with a transparent plastic sheet and folded in half, along a perforation in its center to permanently seal the card within the transparent plastic enclosure.
US08383216B1 Case for a portable electronic device with over-molded thermo-formed film
The present disclosure relates to a case for a personal electronic device comprising one or more layers formed from a thin-film thermo-formed material and methods to manufacture the same. In a disclosed embodiment, the case for the personal electronic device comprises a flexible inner layer and a thin-film thermo-formed outer-layer.
US08383214B2 Diffusion barrier coatings having graded compositions and devices incorporating the same
A composite article comprises a substrate having at least a substrate surface and a graded-composition coating disposed on a substrate surface. The composition of the coating material varies substantially continuously across its thickness. The coating reduces the transmission rates of oxygen, water vapor, and other chemical species through the substrate such that the composite article can be used effectively as a diffusion barrier to protect chemically sensitive devices or materials. An organic light-emitting device incorporates such a composite article to provide an extended life thereto.
US08383209B2 Magnetic recording medium manufacturing method and laminate manufacturing method
[Problems] To have a thin film suitably function even when the thickness of the thin film is reduced.[Means for Solving Problems] Provided is a method for manufacturing a magnetic recording medium by forming a thin film on a substrate (12). The method is provided with a thin film forming step of forming the thin film by using a substance brought into the plasma state as a material. In the thin film forming step, the thin film is formed by using a material substance gathering means (30) for gathering the substance brought into the plasma state to the periphery of the substrate. The material substance gathering means (30) gathers the substance brought into the plasma state, for instance, to the periphery of the substrate (12) by generating a magnetic field at the periphery of the substrate (12).
US08383208B2 Method of fabricating organic light emitting device
Methods of fabricating an organic light emitting device using plasma and/or thermal decomposition are provided. An insulating layer is formed by reacting first and second radicals. The first radical is formed by passing a first gas through a plasma generating region and a heating body, and the second radical is formed by passing a second gas through the heating body. The methods improve the characteristics of the resulting insulating layer and increase the use efficiency of the source gas by substantially decomposing the source gas. The insulating layer can be a passivation layer formed on an organic light emitting device. The methods use plasma apparatuses such as an inductively coupled plasma chemical vapor deposition (ICP-CVD) apparatuses or plasma enhanced chemical vapor deposition (PECVD) apparatuses.
US08383204B2 Siloxane oligomer treatment for metals
A method of applying to a clean metal surface an aqueous solution comprised of a small percentage of organofunctional siloxane oligomers. The organofunctional siloxane oligomers used in this method include silsesquioxanes. The organofunctional siloxane oligomers are applied to a metal surface prior to the application of a topcoat and function to inhibit corrosion of the metal surface.
US08383203B2 Imparting high-temperature degradation resistance to components for internal combustion engine systems
A method of imparting high-temperature, degradation resistance to a component associated with an internal combustion engine involving applying a metal slurry comprising a Co-based metallic composition, a binder, and a solvent to a surface of the component, and sintering the Co-based metallic composition to form a substantially continuous Co-based alloy coating on the surface of the body. An internal combustion engine component comprising a metallic substrate and a Co-based metallic coating thereon which has a thickness between about 100 and about 1000 microns.
US08383201B2 Method and apparatus for coating a thin film substrate
A method including passing a substrate by at least one slot die in at least a first direction and applying at least one coating to the substrate with the slot die, where the slot die is moved in a direction transverse to the at least first direction.
US08383196B2 Method for producing glass substrate for magnetic disk and method for producing magnetic disk
In a method in which a cut line is formed on one surface of a planar glass material, and the cut line is allowed to extend in the thickness direction of the glass material, thereby cutting a glass substrate from the glass material, the cut line is selectively formed on a surface having relatively small surface waviness out of two opposing surfaces of the glass material. In the case of a glass material formed into a planar shape on a molten metal, the surface which has come into contact with the molten metal is selected as the surface having relatively small surface waviness. When a disk-shaped glass substrate is cut from the glass material, cutting is performed under conditions where either one of the thickness and the radius of the glass material and the maximum height of surface waviness of the glass material satisfy a predetermined relationship.
US08383193B2 Film formation method and method for manufacturing light-emitting element
There is a problem in a method for forming an EL layer by heating with light and transferring an organic material in that the organic material is not uniformly transferred. The present invention relates to a film formation method including the steps of forming a metal film over a first surface of an elastic substrate; forming an organic material layer onto a second surface of the elastic substrate which is opposite to the first surface; placing the second surface of the elastic substrate and a substrate on which a film is to be formed, with a space between the second surface of the elastic substrate and the substrate on which a film is to be formed; heating locally and rapidly the metal film from a first surface side of the elastic substrate to deform the elastic substrate by expansion of the metal film; and transferring the organic material layer from the elastic substrate onto the substrate on which a film is to be formed.
US08383192B2 Process for making contained layers and devices made with same
There is provided a process for forming a contained second layer over a first layer, including the steps: forming the first layer having a first surface energy; treating the first layer with a reactive surface-active composition to form a treated first layer having a second surface energy which is lower than the first surface energy; exposing the treated first layer with radiation; and forming the second layer. There is also provided an organic electronic device made by the process.
US08383190B2 Method of chemical protection of metal surface
A process for forming a protective layer on a metal surface includes the steps of: providing a metal material having an oxygen containing layer; applying at least two compounds to the oxygen containing layer of the metal material wherein a first compound applied is a molecularly large compound; and applying at least a second compound to the oxygen containing layer of the metal material wherein the second compound is molecularly small.
US08383188B2 High strength suture coated with RGD peptide
A high strength surgical suture material with improved tie down characteristics and tissue compliance formed of ultrahigh molecular weight polyethylene (UHMWPE) yarns, the suture being coated with arginine-glycine-aspartate (RGD) peptide. The suture has exceptional strength, is ideally suited for most orthopedic procedures, and can be attached to a suture anchor or a curved needle.
US08383182B2 Tofu prepper
An apparatus for easily removing excess moisture from blocks of tofu. The apparatus comprises a container which holds the tofu. A first substantially flat plate member is disposed within such container and placed on top of the tofu. A second substantially flat plate member which has a spring attached thereon engages a pair of arm like projections disposed on upper surfaces and on opposite sides of the container member. The other end of the spring engages the upper surface of the first flat plate member that sits on the top of the tofu so that as the spring exerts pressure on the first flat plate member water is removed from the tofu.
US08383178B2 Stabilisation of pigments and polyunsaturated oils and oil concentrates
The present invention relates to a method for stabilizing vegetable, marine and single cell oils/oil concentrates as well as pigments like astaxanthin and canthaxanthin with regard to oxidation. It also relates to a feed for salmonids, and a method for optimising the effect of the pigment in feed for salmonids. Furthermore, the invention relates to a health care product and a composition for prophylaxis or therapeutical treatment. Essential features by the invention are treatment by or presence of amines/amides.
US08383177B2 Method and system for reducing pathogens
A method and system is provided whereby pathogens in food are reduced by first sealing food in a package and then applying high hydrostatic pressure to the sealed package. The package is moved to a clean area having pathogen-reducing treatment such as a cleansing plasma. The food is removed from the sealed package and then transferred to a food processor such as a grinder or dicer having internal pathogen reducing treatment. The food may then be transferred to a patty maker having internal cleansing plasma. The food may then be transferred to a freezer or freeze dryer having internal cleansing plasma.
US08383173B2 Method of making bread
A method of making bread is provided. The method includes a thermally treated dough making process of forming a thermally heated dough, a dough mixing process of mixing the thermally treated dough of the thermally treated dough making process with wheat flour, dried yeast, refined sugar, refined salt, whole milk powder, bread improver, processed butter, milk, egg, and water to form a dough mixture, and stirring the dough mixture, a deep-freezing process of dividing the dough mixture into equal-sized dough pieces and deep-freezing the divided dough pieces, a thawing process of thawing the deep-frozen dough pieces, a fermentation process of fermenting the thawed dough pieces, and a baking process of heating the fermented dough pieces.
US08383171B2 Oregano oral care compositions and methods of use thereof
A multi-benefit oral composition is provided. The oral composition is efficacious as an antibacterial, antiplaque, anti-inflammatory, anti-oxidant, and anti-halitosis oral composition. The active ingredient has one or more active compounds from an extract of oregano. The oral composition can be in the form of a mouth rinse; a dentifrice, including toothpaste, gels, powders; animal products; a film; or confectionaries, such as lozenges, and the like. Methods of making and using the oral composition are also provided.
US08383169B1 Hard or chewable candies, beverage, and dietary supplement containing kava root extract, lemon balm, and chamomile
A hard or chewable candy, beverage, effervescent powder or tablet, or dietary supplement composition serves as a relaxant and mind energizer. The combination affords the benefit of reduction in the incidence or severity of stomach upset and/or hangover sometimes associated with the primary ingredient, kavalactones. The composition comprises kava root extract and at least one additional component of lemon balm or chamomile extract.
US08383168B2 Antioxidant complex, cosmetic and pharmaceutical compositions containing said complex and use of said complex
The present application describes an antioxidant complex having a synergistic effect between its ingredients. Said mixture comprises: a) vitamin E and/or derivatives thereof; b) green tea extract and/or derivatives thereof; and c) cacao extract. Examples of cosmetic and pharmaceutical compositions comprising said antioxidant complex and a physiologically acceptable carrier are also described. The antioxidant complex of the present invention, as well as the aforementioned compositions, aid in preventing and protecting against cell and skin damages resulting from the action of free radicals, and also provide DNA, protein and cell membrane protection.
US08383163B2 Fluoride varnish compositions including an organo phosphoric acid adhesion promoting agent
Fluoride varnish compositions for temporary application and adhesion to a person's teeth. The composition includes a carrier comprising a resin and an adhesion promoting agent comprising an alkyl phosphoric acid. A fluoride ion source (e.g., a fluoride salt such as sodium fluoride) is dispersed within the carrier so as to provide biologically available fluoride ions to the tooth tissue being treated. The composition adheres only temporarily to tooth tissue (e.g., for a period of at least about 4 minutes, but not more than about 1 year), after which the composition spontaneously wears away as a natural result of the action of the tongue, saliva and/or other factors.
US08383162B2 PHα1B toxin, CDNA of PHα1B toxin gene, pharmaceutical composition containing PHα1B toxin, process for their production and product
Methods and compositions for blocking calcium channels with a spider toxin from Phoneutria nigriventer are provided. For easy identification the toxin will be sometimes generally referred to as Phα-1B herein. The toxin comprises a 55-amino acid sequence having a molecular weight of approximately 6,017. This Phα-1B spider toxin was found to block calcium channels within the nervous system. The synthetic gene responsible for producing this toxin has been designed and cloned. This gene and/or its derivative provide a mechanism by which the toxin can be produced using recombinant DNA expression technologies. The present invention further relates to methods of treating neurological diseases and pain by applying the isolated and identified toxins. The toxin Phα-1B may provide beneficial effects on pain and certain neurological conditions including seizures, ischemic- hypoxic, CNS damage, and neurodegenerative disorders. It was also found that the toxins are effective as tags in probing calcium channels.
US08383158B2 Methods and compositions to treat myocardial conditions
Methods, devices, kits and compositions to treat a myocardial infarction. In one embodiment, the method includes the prevention of remodeling of the infarct zone of the ventricle. In other embodiments, the method includes the introduction of structurally reinforcing agents. In other embodiments, agents are introduced into a ventricle to increase compliance of the ventricle. In an alternative embodiment, the prevention of remodeling includes the prevention of thinning of the ventricular infarct zone. In another embodiment, the prevention of remodeling and thinning of the infarct zone involves the cross-linking of collagen and prevention of collagen slipping. In other embodiments, the structurally reinforcing agent may be accompanied by other therapeutic agents. These agents may include, but are not, limited to pro-fibroblastic and angiogenic agents.
US08383155B2 Swellable dosage form comprising gellan gum
A novel dosage form. The dosage form is presented in particulate form and before oral ingestion the particulate material is subjected to an aqueous medium, whereby it is converted to a semi-solid form by swelling or gelling of one or more of the components, especially of a gellan gum, of the particulate matter. The invention also relates to a vehicle for oral administration of one or more active substances, the vehicle comprising a gellan gum arranged in a configuration allowing optimal water diffusion so that upon addition of a predetermined amount of an aqueous medium, without the necessity of applying shear forces or other mixing forces, within a time period of 5 minutes or less swells and/or gels and the texture of the swelled vehicle being similar to that of a soft pudding and having a viscosity of at least about 10,000 cps as measured by a Brookfield Viscometer with a #4 LV spindle at 6 rpm and at 20-25° C. In one embodiment of the invention, the particulate matter can be molded into a desired shape or pressed onto a dispensing unit such as a spoon.
US08383154B2 Swellable dosage form comprising gellan gum
A novel dosage form. The dosage form is presented in particulate form and before oral ingestion the particulate material is subjected to an aqueous medium, whereby it is converted to a semi-solid form by swelling or gelling of one or more of the components, especially of a gellan gum, of the particulate matter. The invention also relates to a vehicle for oral administration of one or more active substances, the vehicle comprising a gellan gum arranged in a configuration allowing optimal water diffusion so that upon addition of a predetermined amount of an aqueous medium, without the necessity of applying shear forces or other mixing forces, within a time period of 5 minutes or less swells and/or gels and the texture of the swelled vehicle being similar to that of a soft pudding and having a viscosity of at least about 10,000 cps as measured by a Brookfield Viscometer with a #4 LV spindle at 6 rpm and at 20-25° C. In one embodiment of the invention, the particulate matter can be molded into a desired shape or pressed onto a dispensing unit such as a spoon.
US08383153B2 Poly(amidoamine) oligomer hydrogel for drug delivery and drug carrier using the same
Disclosed is a temperature- and pH-sensitive hydrogel composed of a poly(amidoamine) oligomer only. The hydrogel is prepared in a simple manner and is readily released from the body. Further disclosed are a method for preparing the hydrogel and a drug carrier using the hydrogel.
US08383150B2 Granulate formulation of pirfenidone and pharmaceutically acceptable excipients
A capsule formulation of pirfenidone is provided that includes pharmaceutically acceptable excipients. In one embodiment, this capsule formulation is capable of sustaining desirable pharmacokinetic responses in a patient. Further provided are methods of treating fibrotic conditions and other cytokine-mediated disorders by administering pirfenidone capsules of such formulation to a patient in need.
US08383147B2 Reinforced absorbable synthetic matrix for hemostatic applications
The present invention is directed to a reinforced absorbable hemostat comprising at least one hemostatic agent in a single layer of nonwoven synthetic fabric having a mixture of compressed fiber staples of a polyglycolide/polylactide copolymer and a polydioxanone.
US08383146B2 Compositions for oral adminstration of active principles requiring masking of taste
A process for the preparation of a composition intended for the oral administration of active principles with unacceptable taste, which comprises from about 15% to about 30% of organoleptically unpleasant active ingredient (principle) that is mixed with from about 60% to about 80% of an ester of glycerol or of a fatty acid, to which a wax is optionally added and to which a surfactant is added, and in that it is prepared by a spray-cooling process which can produce a particle size of less than 350 μm.
US08383144B2 Tissue adhering compositions
A method mixes a first component, a second component, and a buffer material. The first component includes an electrophilic polymer material comprising poly(ethylene glycol) having a functionality of at least three. The second component includes a nucleophilic material comprising a natural or synthetic protein at a concentration of about 25% or less that, when mixed with the first component within a reaction pH range, cross-links with the first component to form a non-liquid, three-dimensional barrier. The buffer material includes tris-hydroxymethylaminomethane having a pH within the reaction pH range. The method applies the mixture to adhere to a tissue region.
US08383139B2 Thiadiazolyloxyphenylamidines and use thereof as fungicides
The present invention relates to thiadiazolyloxyphenylamidines of the general formula (I), to a process for the preparation thereof, to the use of the amidines according to the invention in combating undesirable microorganisms and to a composition for this purpose comprising the thiadiazolyloxyphenylamidines according to the invention. The invention furthermore relates to a method for combating undesirable microorganisms by application of the compounds according to the invention to the microorganisms and/or to the habitat thereof.
US08383138B2 Shark repelling method
A method of repelling sharks for limiting their attacking a surfboard user comprises applying a conventional surfboard traction improving solid wax that also incorporates a shark repellent such as a surfactant, a capsaicinoid or a semiochemical in a concentration based on the “Johnson & Baldridge Test”. The extent of application is consequently sufficient to render the coated surfboard foul tasting when bitten by a shark but insufficient to reliably repel a shark in response to the dispersion in the water of the repellent. The invention extends to a shark repellent incorporating surfboard coating wax.
US08383137B2 Agricultural adjuvant compositions, herbicide compositions, and methods for using such compositions
Pesticide compositions that contain, based on 100 pbw of such composition, (a) greater than or equal to about 0.006 parts by weight of a betaine surfactant, (b) greater than or equal to about 0.02 parts by weight of a humectant selected from polyhydric alcohols, polysaccharide humectants, and mixtures thereof, and (c) an effective amount of a pesticide, exhibit reduced foaming and high efficacy.
US08383136B2 Micelle encapsulation of therapeutic agents
The invention provides active agents, such as paclitaxel, rapamycin, or 17-AAG, encapsulated by safe poly(ethylene glycol)-block-poly(lactic acid) (“PEG-b-PLA”) micelles. The compositions provide effective solubilization of drug combinations, such as paclitaxel, rapamycin, and 17-AAG, as well as others described herein. A significant advantage of PEG-b-PLA as a carrier is that it is less toxic than Cremophor® EL or DMSO, which are used in currently known compositions. Additionally, PEG-b-PLA micelles are easier to handle than DMSO and they do not possess a foul odor, which is a problem with formulations currently in clinical trials. Accordingly, the invention provides stable and biocompatible drug formulations that improve bioavailability without causing toxicity. It was also found that larger doses of individual drugs in micelle formulations can be administered compared to non-micelle formulations.
US08383134B2 Biodegradable material based on opened starch
The present application relates to a biodegradable material comprising opened starch or a mixture of opened starch and destructurised starch. The biodegradable material comprises about 50 to about 100 wt. % of opened starch or of a mixture of opened starch and destructurized starch, based on the total weight of the biodegradable material, said biodegradable material having a bulk density of 1.0 to 1.5 kg/dm. The biodegradable material is used for manufacturing biodegradable shaped articles, wherein said biodegradable shaped articles are suitable for delivery of a biologically or pharmaceutically active component in or to a vertebrate, e.g. a mammal.
US08383131B2 Porcine reproductive and respiratory syndrome isolates and methods of use
A method of predicting the virulence of a new or uncharacterized PRRS virus strain is provided wherein the strain is injected into swine and allowed to replicate for a period of from about 3-15 days. During this period, the rate of virus growth and/or the magnitude of viremia is determined, and this data is compared with a corresponding growth rate and/or viremia magnitude of a PRRS virus strain of known virulence, as a measure of the virulence of the new or uncharacterized strain.
US08383124B2 Mobilization of hematopoietic stem cells
Methods, processes, uses, and pharmaceutical compositions are provided herein for mobilizing hematopoietic progenitor cells and/or cancer stem cells from bone marrow into peripheral blood, comprising the administration of an effective amount of an inhibitor of GTPases, such as a Cdc-42 specific inhibitor alone or in combination with one or more additional agents. Specifically, methods are disclosed for mobilizing hematopoietic stem cells into a subject's peripheral blood. In particular, embodiments of the method involve specific inhibition of the Cdc42 GTPase to increase the numbers of hematopoietic stem cells into a subject's peripheral blood of a subject.
US08383123B2 Method of treatment targeting HEPSIN
Anti-HEPSIN monoclonal antibodies, and methods for using the antibodies, are provided.
US08383122B2 Process for preparing purified drug conjugates
The invention provides a process for preparing a cell-binding agent chemically coupled to a drug. The process comprises covalently attaching a linker to a cell-binding agent, a purification step, conjugating a drug to the cell-binding agent and a subsequent purification step.
US08383116B2 Anti-leukocyte recruitment therapy for the treatment of seizures and epilepsy
Methods are provided for the prevention and treatment of seizures and epilepsy. It is shown herein that leukocyte recruitment plays a key role in the pathogenesis of epilepsy. Treatment with an agent that inhibits leukocyte recruitment has therapeutic and preventative effects in blocking recurrent seizures and epilepsy.
US08383112B2 Targeting VEGF-B regulation of fatty acid transporters to modulate human diseases
The present invention provides materials and methods for modulating FATP expression and/or activity in vivo. The materials and methods have numerous diagnostic, prophylactic, and therapeutic applications for various diseases and conditions that are influenced by FATPs, or characterized by excessive or inadequate FATP expression or activity.
US08383111B2 Inotropic antibodies and therapeutic uses thereof
Antibodies binding to sites on the alpha-subunit of the (Na++K+)-ATPase increase cardiac contraction of both ventricular myocytes and mouse heart. In particular, antibodies binding to the RSATEEEPPNDD (SEQ ID NO: 1) or DVEDSYGQQWTYEQR (SEQ ID NO: 2) peptides (or isoforms/derivatives thereof) of the alpha-subunit of the (Na++K+)-ATPase, have been found to be highly inotropic. Both the antibodies and the peptides are important for the treatment of human heart failure and other contractile disorders.
US08383109B2 Optimized Fc variants and methods for their generation
The present invention relates to optimized Fc variants, methods for their generation, and antibodies and Fc fusions comprising optimized Fc variants.
US08383106B2 Materials and methods for improved immunoglycoproteins
Immunoglycoproteins, including antibodies, with improved ADCC and altered glycosylation patterns are provided. Also provided are cell culturing methods and media for producing such immunoglycoproteins, and therapeutic uses of such immunoglycoproteins.
US08383101B2 Compositions and methods comprising serratia peptidase for inhibition and treatment of biofilms related to certain conditions
Physiologically acceptable anti-biofilm compositions comprising Serratia peptidase and optionally one or more of bromelain, papain and a fibrinolytic enzyme. Additional components can include antimicrobials, antibiotics, antifungals, herbals, chelating agents, lactoferrin and related compounds, minerals, surfactants, binders, and fillers useful for the inhibition and treatment of gastrointestinal biofilms in humans. Physiologically acceptable anti-biofilm compositions containing these enzymes are useful in the inhibition, reduction and/or treatment of biofilms such as in the ear, vagina, joints, bones, gut, surgical sites and other locations, and are useful for the inhibition, reduction and/or treatment of associated systemic symptoms caused by biofilm associated microorganisms.
US08383093B1 Subcutaneous delivery of poly(oxazoline) conjugates
The present disclosure provides polymer conjugates comprising a polymer and an agent, the agent linked to the polymer via a linking group containing a hydrolyzable moiety.
US08383081B2 Anti-CD74 immunoconjugates and methods of use
Disclosed are compositions that include anti-CD74 immunoconjugates and optionally a therapeutic and/or diagnostic agent. In preferred embodiments, the immunoconjugates comprise one or more anti-CD74 antibodies or antigen-binding fragments thereof, conjugated to a carrier such as a polymer, nanoparticle, complex or micelle. Also disclosed are methods for preparing the immunoconjugates and using the immunoconjugates in diagnostic and therapeutic procedures. In certain preferred embodiments, the therapeutic methods comprise administering to a subject with a CD74-expressing disease an anti-CD74 immunoconjugate and thereby inducing cell death of CD74-expressing cells. In more preferred embodiments, the CD74 immunoconjugate is capable of inducing cell death in the absence of any other therapeutic agent, although such agents may be optionally administered prior to, together with or subsequent to administration of the anti-CD74 immunoconjugate. The compositions may be part of a kit for administering the anti-CD74 immunoconjugates or compositions.
US08383079B2 Molecular sieves having micro and mesoporosity, their synthesis and their use in the organic conversion reactions
A crystalline molecular sieve comprises at least [AlO4] and [PO4] tetrahedral units and comprising a first framework structure defining a first set of uniformly distributed pores having an average cross-sectional dimension of from about 0.3 to less than 2 nanometers and further comprising a second framework structure defining a second set of uniformly distributed pores having an average cross-sectional dimension of from 2 to 50 nanometers. The first framework structure is preferably of the CHA framework type.
US08383076B2 Formation of silica compositions using low surfactant concentrations
A silica composition and a method for forming the silica composition using low surfactant concentrations are disclosed. A metal silicate precursor including a silica source and a hydroxide MOH is prepared, where M is a cation with a valence of 1. In addition, a surfactant solution including a cationic surfactant and an anionic co-surfactant is prepared. Next, the metal silicate precursor and the surfactant solution are mixed to form a mixture. Then the mixture is crystallized to form the silica composition and the silica composition is isolated. The cationic surfactant can have 10 or more carbon atoms, the anionic co-surfactant can have 4 or more carbon atoms, the molar ratio of the cationic surfactant to the silica source can be less than or equal to 0.1:1, the molar ratio of the anionic co-surfactant to the silica source can be less than or equal to 0.1:1, and the molar ratio of the anionic co-surfactant to the silica source can be less than the molar ratio of the cationic surfactant to the silica source.
US08383074B2 Process and device for simultaneously desulfurizing and denitrating the flue gas with the seawater
A process for simultaneously desulfurizing and denitrating the flue gas with seawater includes the following steps: 1) catalytically scrubbing the flue gas containing SO2 and NOx with the seawater to obtain purified flue gas and acidic seawater, optionally adding a certain quantity of iron ions into the seawater or applying magnetic field during scrubbing; 2) adding seawater into the acidic seawater while blowing air in so as to restore the quality of the acidic seawater up to the environmental standards. Also a device used in the process is provided.
US08383072B2 Gas separation process
A process for the separation of carbon dioxide from gas mixtures is disclosed in which a metal oxide sorbent, which is used to capture and release carbon dioxide, is recycled. The process incorporates the regeneration of the carbon dioxide capture capacity of the metal oxide to maintain a high capture capacity over many cycles. The regeneration involves hydrating the metal oxide and then heating the resulting metal hydroxide under a gas atmosphere that is effective to suppress the dehydration of the hydroxide so that dehydration occurs at an elevated temperature. The regeneration may also be used independently from the carbon dioxide separation process to produce, from a metal hydroxide, a metal oxide having an enhanced resistance to attrition and fragmentation.
US08383071B2 Process for dilute phase injection of dry alkaline materials
The present disclosure is directed to the introduction of an additive to a contaminated gas stream using an additive introduction system including one or more of a compressor, a cooled lance, and an educator nozzle on the lance to inhibit scaling from the additive or a derivative thereof.
US08383070B2 Method for recovering rhenium and other metals from rhenium-bearing materials
A method of recovering rhenium (Re) and other metals from Re-bearing materials in the form of ammonium perrhenate having at least the step of adding Re-bearing materials into a leaching slurry. Additionally, the method has the step of adjusting the pH of the slurry to obtain Re in soluble form in a metal salt solution and insoluble residues; filtering the metal salt solution to remove the insoluble residues; selectively precipitating Re from the metal salt solution; filtering the Re precipitate from the metal salt solution to obtain a Re filtercake; and formulating and drying the Re filtercake to obtain a Re sulfide product. The method further has the step of combining the Re sulfide product with a Molybdenum (Mo) concentrate containing Re to obtain a Mo/Re concentrate; roasting the Mo/Re concentrate to obtain Mo oxide product and a flue gas containing Re; and treating the flue gas containing Re to obtain ammonium perrhenate.
US08383068B2 Apparatus for performing amplicon rescue multiplex PCR
A cassette for performing multiplex PCR is described. The cassette allows for the automated amplification and detection of multiple nucleic acid targets while limiting contamination. The device facilitates a two-amplification, two-primer PCR protocol which results in highly specific, highly sensitive and semi-quantitative amplification of multiple nucleic acid targets. The cassette contains a cavity, a base with a plurality of chambers, a movable pipette for the transfer of reagents and a detection area. The cassettes are single use, disposable devices which may be loaded with reagents needed for the detection of multiple targets. The cassettes may be used in a hospital or clinical setting to quickly screen clinical samples and detect the presence of infectious agents.
US08383067B2 Biopsy support with sectionable resilient cellular material
A histologic tissue sample support device includes a tissue support formed of material that can be successfully sectioned in a microtome and is resistant to degradation from solvents and chemicals used to fix, process and stain tissue. A resilient cellular material is coupled to the tissue support and is configured to engage and retain tissue in place during processing and embedding. The resilient cellular material is also capable of successful sectioning in the microtome and porous to allow infiltration of the solvents and chemicals used to fix, process and stain tissue, and of embedding material used to embed the tissue while the tissue is retained by the resilient cellular material.
US08383066B2 Filter vial
A filter vial and piston are provided where the vial has a cylindrical wall with a closed bottom and open top and with the hollow, tubular piston therein. The piston has a distal end covered by a cup having a proximal cup seal extending outward to engage the walls of the vial to form a fluid tight seal with the vial during use. The distal end of the piston has a piston flange extending outwardly and located adjacent a recess in the piston so the cup forms a snap fit over the piston flange and extends into the recess. The piston flange causes the cup to bulge sufficiently outward to form a fluid tight seal with the vial during use. A filter is placed in the bottom of the cup and abuts an inwardly extending lip on the cup. The filter is held against the lip by a piston support at the distal end of the piston. A cup support at a distal end of the cup also helps support the filter.
US08383063B2 Microchip and microchip manufacturing method
A microchip 1 in which a resinous film can be inhibited from sagging into a channel. The microchip 1 comprises: a resinous substrate 2 having a channel groove formed therein; and a resinous film bonded to a surface of the substrate on which the channel groove has been formed. A micro-channel 3 including channels 3A and channels 3B is formed by the channel groove and the resinous film 10. The total length of the channels 3B, which is parallel to the X direction for the resinous substrate 2, is larger than the total length of the channels 3A, which is parallel to the Y direction for the resinous substrate 2. The resinous substrate 2 has been bonded to the resinous film so that the sides parallel to the channels 3B are parallel to the TD direction of the resinous film and that the sides parallel to the channels 3A are parallel to the MD direction of the resinous film.
US08383055B2 Anchor system for refractory lining
An anchoring system is provided for supporting a double-layered refractory lining of a process vessel. The refractory lining includes a first layer positioned adjacent to an inner surface of the process vessel and a second layer positioned adjacent to the first layer. The anchoring system has a plurality of bifurcated anchors extending from the internal surface of the process vessel through the first layer and into the second layer of the double-layered lining adjacent the first layer wherein the plurality of bifurcated anchors have a bifurcation disposed within the second layer.
US08383051B2 Separating and stripping apparatus for external FCC risers
The present invention provides a compact riser separation system for Fluid Catalytic Cracking reactors possessing an external riser system wherein the riser enters the reactor from outside the reactor vessel.
US08383046B1 Analyzer apparatus for measuring dissolved volatile substances and method
Analyzer apparatus for measuring amounts of a specific analyte dissolved in a liquid includes a measurement cavity block defining a measurement cavity and an analyte inlet in communication with the measurement cavity, an analyte sensor assembly selected to sense the specific analyte being affixed to the block in communication with the measurement cavity and sealing the measurement cavity from environment outside the measurement cavity, and a semipermeable membrane affixed to the measurement cavity block over the analyte inlet with the measurement cavity being sealed from environment outside the measurement cavity except for analyte entering the measurement cavity through the semipermeable membrane.
US08383043B2 Analyzer system
A system relating to sample analyzers, and more particular, to sample analyzers that are simple to operate and have a reduce risk of providing an erroneous result to a user. In some cases, the sample analyzer may be a portable sample analyzer that includes a disposable fluidic cartridge. The operators of the analyzers need not be trained.
US08383041B2 Body fluid testing device
Body fluid testing device for analyzing a body fluid comprises a test media tape adapted to collect the body fluid. The test media tape comprises a tape and test media portions. A free tape portion without test medium is located between successive test media portions. The testing device further comprises a supply portion. The supply portion comprises a housing in which uncontaminated test media tape is contained. The housing further has an opening for withdrawing test media tape from the housing. The testing device further has a sealing means for closing the opening against the surrounding. A free tape portion of the test media tape is located between a wall of the housing and the sealing means when the sealing means closes the opening. Further aspects concern a test media cassette with sealing means and a method for providing test media while holding them sealed against humidity during onboard storage.
US08383040B2 Analytical test tape instrument
An analytical test tape instrument includes an exchangeable test tape unit which comprises a test tape provided with a plurality of test elements to which body fluid can be applied. The test tape instrument also includes a tape drive that can be coupled with the test tape unit to wind the test tape so that the test elements can be successively made available at an application site. The tape drive has a direct current motor and a reduction gear unit arranged between the direct current motor and the test tape unit.
US08383039B2 Self-contained biological assay apparatus, methods, and applications
A self-contained, fully automated, biological assay-performing apparatus includes a housing; a dispensing platform including a controllably-movable reagent dispensing system, disposed in the housing; a reagent supply component disposed in the housing; a pneumatic manifold removably disposed in the housing in a space shared by the dispensing platform, removably coupled to a fluidic transport layer and a plurality of reservoirs, wherein the fluidic transport layer, the reservoirs, and a test sample to be introduced therein are disposed in the housing in the space separate from the dispensing platform; a pneumatic supply system removably coupled to the pneumatic manifold in the housing in a space separate from the dispensing platform; and a control system coupled to at least one of the dispensing platform and the pneumatic supply system, disposed in the housing.
US08383037B2 Gamma hardened pharmaceutical devices
A system and method for implementing embedded electronics in environments where radiation or extreme temperatures are used is disclosed. Embedded electronics are affixed to various components of a pharmaceutical system, thereby enabling the customer to download pertinent information about the component, such as lot number, date of manufacturer, test parameters, etc. Additionally, these electronics allow an array of functions and features to be implemented, such as integrity tests and diagnostics. The electronics in the pharmaceutical components utilize a technology that is not as susceptible to radiation and extreme temperatures as traditional electronics.
US08383036B2 Methods for neutralizing anthrax or anthrax spores
The present invention concerns methods, compositions and apparatus for neutralizing bioagents, wherein bioagents comprise biowarfare agents, biohazardous agents, biological agents and/or infectious agents. The methods comprise exposing the bioagent to an organic semiconductor and exposing the bioagent and organic semiconductor to a source of energy. Although any source of energy is contemplated, in some embodiments the energy comprises visible light, ultraviolet, infrared, radiofrequency, microwave, laser radiation, pulsed corona discharge or electron beam radiation. Exemplary organic semiconductors include DAT and DALM. In certain embodiments, the organic semiconductor may be attached to one or more binding moieties, such as an antibody, antibody fragment, or nucleic acid ligand. Preferably, the binding moiety has a binding affinity for one or more bioagents to be neutralized. Other embodiments concern an apparatus comprising an organic semiconductor and an energy source. In preferred embodiments, the methods, compositions and apparatus are used for neutralizing anthrax spores.
US08383035B2 Removing method of smells
A system and method of removing odors by adsorbing steam vapor and exhausting the odors by generating a forcible flow is provided. The system may include a rotatable drum for receiving items to be deodorized, a steam generator for supplying steam to the drum, and a passage for generating a forcible flow through the drum. The method may include adsorbing steam generated by the steam generator by the items to be deodorized, and exhausting the adsorbed steam using the forcible flow through the drum.
US08383031B2 Method for modifying pore size distribution zones in fiber cement composites and articles of manufacture of the same
A cementitious product and method of modifying the properties of a low or medium density FRC product by providing a predetermined pore size distribution. The pore size distribution is obtained such that in critical zones of the distribution, the pore volume is substantially equivalent to or less than the pore volume in a respective critical zone of a conventional high density FRC product. The resultant material provides improved properties over conventional medium density FRC products, in particular improved freeze/thaw durability and/or improved workability.
US08383030B2 Apparatus and method for making suture packages
Apparatus and method for making a plurality of different types of suture packages employ a mold with first and second opposing mold parts partially defining a mold cavity, at least one of the opposing mold parts has an opening therein communicating with the mold cavity. An insert is removeably inserted into the opening, to complete the mold cavity in a form suitable for molding a first type of suture package. An alternative insert is interchangeable with the first insert for completing the mold cavity in a form suitable for molding a second type of suture package. To make different suture packages, the mold is initially configured and used with one of the inserts to thereby make one type of suture package. The first insert is then replaced with the second, changing the mold cavity to form another type of suture package.
US08383029B2 Manufacture of high strength, high density carrier plate
A carrier plate for supporting electronic components during processing includes hexagonally-arranged holes for supporting the components. Walls of the holes comprise a gripping resilient material. The hexagonal arrangement provides a strong carrier that improves production yield through an increase in per batch processing and improved locational accuracy over conventional carriers.
US08383020B2 Dielectric fluid composition containing vegetable oils and free of antioxidants
A dielectric fluid composition containing of 60% to 63% in weight of mono-unsaturated fatty acid, of 20% to 23% in weight of di-unsaturated fatty acid, of 5% to 7% in weight of tri-unsaturated fatty acid, and of 6% to 8% in weight of saturated fatty acid, such that the dielectric fluid is free of antioxidants and/or external additives and has the following properties: a dielectric strength of 40 kV to 70 kV at a separation of 2 mm, a dielectric constant of 2.5 to 3.1 at 25° C., and a dissipation factor of 0.05% to 0.15% at 25° C. The dielectric fluid composition can be obtained by a combination of 95.5% to 99.25% in weight of at least one high oleic vegetable oil, of 0.25% to 1.5% in weight of grape seed oil, of 0.25% to 1.5% in weight of sesame seed oil, and of 0.25% to 1.5% in weight of rice bran oil.
US08383019B2 Sputtering target, transparent conductive film and transparent electrode
A sputtering target including indium, tin, zinc and oxygen, and including a hexagonal layered compound, a spinel structure compound and a bixbyite structure compound.
US08383018B2 Method of forming nanocomposite solution, and nanocomposite photovoltaic device
Provided is a method of forming a nanocomposite solution, and a nanocomposite photovoltaic device. In the method, a metal oxide nanorod solution is prepared and a nanoparticle solution is prepared. The metal oxide nanorod solution and the nanoparticle solution are mixed to form a nanocomposite solution.
US08383015B2 Copper powder for conductive paste and conductive paste
Copper powder is provided, which, while having fine granularity and resistance to oxidation, does not lose either resistance to oxidation or balance in conductivity, and furthermore, copper powder for conductive paste in which variations in shape and granularity are small and having a low concentration in oxygen content. The copper powder for conductive paste contains 0.05 to 10 atomic % Bi inside each particle.
US08383013B2 Photosensitive paste composition for fabricating the plasma display panel electrode, plasma display panel electrode and plasma display panel thereby
Disclosed herein is a photosensitive paste composition for a plasma display panel (PDP) electrode capable of minimizing edge curl, i.e., a phenomenon in which the edge of an electrode pattern portion is curled during baking and thus improving withstand voltage. The photosensitive paste composition comprises 40 to 55% by weight of a conductive powder, 5 to 15% by weight of an inorganic binder, 35 to 55% by weight of an organic vehicle, and the remaining percentage by weight of a solvent, wherein the inorganic binder is present in an amount of 15 to 35 parts by weight, with respect to 100 parts by weight of the conductive powder. Further disclosed are a plasma display panel (PDP) electrode fabricated using the composition, and a plasma display panel (PDP) comprising the electrode.
US08383011B2 Conductive inks with metallo-organic modifiers
A conductive ink having a glass frit, an organic medium a conductive species and one or more metallo-organic components which form metal oxides upon firing and reduce series resistance to a same or greater degree a ink that do not include metallo-organic components, is provided. Embodiments of conductive ink include metallo-organic components that include a bismuth metallo-organic component and glass frits comprising one or more of bismuth oxide, silica, boron oxide, tellurium dioxide, and combinations thereof. Embodiments of photovoltaic cells with an anti-reflection coating, gridlines formed from conductive ink incorporating one or more metallo-organic components, are also provided.
US08383010B2 Active optical element, method of producing the same
An active element that is based on an electret emulsion and that comprises particles of pre-polarized electret material as emulsion in neutral liquid and both poles of the particles are colored with different colors. For producing a neutral carrier liquid for the active element liquid fluorine carbon is used. For producing electret material for the active element solid polymerised fluorine carbon or electret wax is used. The active element is used for producing visual matrix displays, indicators, surfaces and surface coatings that change color by the application of a control voltage.
US08383009B2 Stabilized compositions of conductive polymers and partially fluorinated acid polymers
There is provided an electrically conductive polymer composition. The composition includes an electrically conductive polymer and a partially-fluorinated acid polymer. At least 50% of acid protons on the partially-fluorinated acid polymer are replaced with cations. The cations can be inorganic cations, organic cations, and combinations thereof.
US08382995B2 Piezoelectric devices and methods for manufacturing same
Methods are disclosed for manufacturing piezoelectric devices. In an exemplary method a base substrate is prepared that defines multiple device bases. Multiple cutting grooves are defined on a surface of the base substrate in a grid pattern to define therebetween the size of the devices. A frame substrate is also prepared from a piezoelectric material. The frame substrate defines multiple frames surrounding respective vibrating pieces and being alignable with respective bases in the base substrate. Also prepared is a lid substrate defining multiple lids being alignable with respective frames and bases. The three substrates are aligned and bonded together such that the frame substrate is between the lid and base substrates and the surface defining the cutting grooves faces outward. The base substrate is mounted on a dicing sheet such that cutting grooves face the dicing sheet. Cutting is performed, using a dicing blade, through the sandwich from the lid substrate to the cutting grooves.
US08382994B2 Method of preparing a composite pressure vessel for use as a water treatment apparatus
The present invention provides a composite pressure vessel containing a distributor plate. The distributor plate comprises a thermoplastic polymeric disk having a top side, a bottom side, a perimeter edge and a central opening. The disk is provided with a plurality of radial slits, which define fluid flow passages through the disk between the central opening and the perimeter edge. The fluid flow passages through the disk are adapted to swirl fluid flowing through the disk from the bottom side to the top side such that it swirls around the central opening. The perimeter edge of the distributor plate is joined to an inner side of a thermoplastic liner during or immediately after the thermoplastic liner is formed by a blow-molding process or a rotational molding process.
US08382993B1 Drain filter apparatus and method
A removable drain filter apparatus (20) with an housing (22) connectable with upstream and downstream drain pipes (40, 46) has a filtering chamber wider than the drain pipes and divided into an upstream portion (78) and a downstream portion (82) by a generally planer filter element (50). A hatch cover (32) carries a downwardly extending central core (76) with an O-ring seal (84), a filter securement member (86) for pressing the filter element (50) against an underlying support ledge (29) and a drain hole plug (88). The location of the O-ring (84) relative to the filter element (50) and the plug (88) being tapered enables the filter housing (22) to be drained of any water during removal of the hatch cover and before the watertight seal is broken to eliminate leakage of drain water out of the housing (22) when the hatch (31) is completely opened. The filter (50) bends out of the way of a plumber's auger (96).
US08382991B2 Method of sorbing discolored organic compounds from water
Discolored organic compounds (DOC) may be extracted from a medium using a sorbent composition derived by sulfidation of red mud, which contains hydrated ferric oxides derived from the Bayer processing of bauxitic ores. In some aspects, the sorbent composition is slurried with the medium. In other aspects, the sorbent composition is formed into pellets or the like, which are contacted with the medium. The red mud (along with adsorbed contaminants) is then separated from the water using any suitable technique, such as filtration, sedimentation, or centrifugation.
US08382989B2 Process for separating a charged species from an aqueous system
The present invention relates to a process for separating a charged species from an aqueous system, wherein the process comprises the following steps: (a) a first aqueous system comprising the charged species is contacted at a first temperature with an ampholytic polymeric 5 system comprising cationic and anionic domains, wherein the charged species is bonded to the ampholytic polymeric system; and (b) the ampholytic polymeric system is contacted with a second aqueous system at a second temperature, wherein the charged species is released to the second aqueous system, wherein the second temperature is higher than the first temperature and wherein the second temperature is higher than the first temperature and wherein the second 10 temperature is less than 60° C.
US08382988B2 Process for the production of ultra pure water using a membrane
The invention is directed to a process for the production of ultra pure water, comprising feeding water containing ions and optionally other impurities to one side of a membrane based on hydroxy sodalite (H-SOD), and recovering ultra pure water from the other side of the membrane.
US08382987B2 Method for harvesting nanoparticles and sequestering biomarkers
Capture particles for harvesting analytes from solution and methods for using them are described. The capture particles are made up of a polymeric matrix having pore size that allows for the analytes to enter the capture particles. The pore size of the capture particles are changeable upon application of a stimulus to the particles, allowing the pore size of the particles to be changed so that analytes of interest remain sequestered inside the particles. The polymeric matrix of the capture particles are made of co-polymeric materials having a structural monomer and an affinity monomer, the affinity monomer having properties that attract the analyte to the capture particle. The capture particles may be used to isolate and identify analytes present in a mixture. They may also be used to protect analytes which are typically subject to degradation upon harvesting and to concentrate low an analyte in low abundance in a fluid.
US08382986B2 Methods of and systems for dewatering algae and recycling water therefrom
A method of dewatering algae and recycling water therefrom is presented. A method of dewatering a wet algal cell culture includes removing liquid from an algal cell culture to obtain a wet algal biomass having a lower liquid content than the algal cell culture. At least a portion of the liquid removed from the algal cell culture is recycled for use in a different algal cell culture. The method includes adding a water miscible solvent set to the wet algal biomass and waiting an amount of time to permit algal cells of the algal biomass to gather and isolating at least a portion of the gathered algal cells from at least a portion of the solvent set and liquid of the wet algal biomass so that a dewatered algal biomass is generated. The dewatered algal biomass can be used to generated algal products such as biofuels and nutraceuticals.
US08382980B2 Household water filter
Apparatus for water purification and used in drinking water supply systems and individual filters. The apparatus allows an increase in quality of the water purification by means of a helical arrangement of a granular filter and an increase of the number of passages in which the water is purified. A household filter comprises a housing with distribution grids at the water inlet and outlet, two and more helical partitions having the form of a flat band or rod twisted around the longitudinal axis and having three or more beam profiles, and, optionally, comprise one or more flat partitions dividing the water inlet and outlet.
US08382978B2 Device and method for cleaning up spilled oil and other liquids
A device and method for cleaning up spilled oil and other liquids that are relatively less dense than water, that have spilled on the water or are borne on water or an other relatively dense liquid, and for separating oil and other liquids that are relatively less dense than water, from water or an other relatively dense liquids including an oil/water separation column having a lower end forming a bottom opening oriented substantially parallel to the surface of the body of water in fluid communication with the water and spilled oil, an air pump in airtight engagement with, and proximate the upper end of the oil/water separation column and adapted to draw water and the spilled oil into the oil/water separation column; and an oil pump in liquid tight engagement with and proximate the upper end of the oil/water separation column and adapted to draw the spilled oil from the oil/water separation column.
US08382973B2 Method and apparatus for controlling multi-gas sensor
A method and apparatus for controlling a multi-gas sensor, including an NOX sensor section and an ammonia sensor section. The NOX sensor section includes a first pumping cell adapted to pump oxygen into or out of a gas under measurement introduced into a first measurement chamber, and a second pumping cell communicating with the first measurement chamber and configured such that a second pumping current Ip2 corresponds to an NOX concentration of the gas under measurement. Oxygen concentration is calculated on the basis of a first pumping current flowing through the first pumping cell, and a corrected ammonia concentration is calculated on the basis of the oxygen concentration and the ammonia concentration output of the ammonia sensor section.
US08382972B2 Method for quantifying a chemical substance with substitutional stripping voltammetry and a sensor chip used therefor
The evaporation of the stripping liquid 6 changes the concentration of the standard electrolyte. This causes the quantification accuracy of the chemical substance to be lowered.In order to solve the above problem, this invention provides a method for quantifying a chemical substance contained in a sample solution, characterized by the following stripping gel.The stripping gel covers the stripping electrode, and contains a standard electrolyte and an ionic liquid; however, the stripping gel contains no water.Furthermore, the ionic liquid is hydrophobic and nonvolatile, and the standard electrolyte is consisted of the anion and a metallic ion.
US08382967B2 Magnetic device and magnetron sputtering device using the same
A magnetron sputtering device includes a base arranged adjacent to a sputtering target, and a plurality of movable magnet assemblies. Each movable magnet assembly includes a support fixed to the base, and a plurality of magnets that are connected to each other, arranged on the support and comprising opposing poles facing the base. Each movable magnet assembly also includes a driving device to drive the plurality of magnets to slide with respect to the support.
US08382966B2 Sputtering system
A sputtering system is disclosed. The sputtering system includes: a first sputter unit including: a first deposition material plate, a second deposition material plate, where the first and second deposition material plates face each other, and a first magnetic field generator disposed behind each of the first deposition material plate and the second deposition material plate, configured to generate a magnetic field, a second sputter unit including: a third deposition material plate, disposed next to the first deposition material plate, a fourth deposition material plate, disposed next to the second deposition plate, where the third and fourth deposition material plates face each other, and a second magnetic field generator disposed behind each of the third deposition material plate and the fourth deposition material plate, configured to generate a magnetic field, a first gas supply pipe disposed between the first and third deposition material plates, configured to discharge gas to the second and fourth deposition material plates, a second gas supply pipe disposed between the second fourth deposition material plates, configured to discharge gas to the first and third deposition material plates, a first substrate support unit, configured to support a first deposition substrate, oriented toward outer edges of the first and second deposition material plates, and a second substrate support unit, configured to support a second deposition substrate, oriented toward outer edges of the third and fourth deposition material plates.
US08382964B1 Solar-powered pool skimmer lid
A solar-powered pool skimmer is disclosed. The solar-powered skimmer may include lid having an upper surface and a lower surface, and a solar cell affixed to the upper surface of the lid. A pair of electrodes is electrically affixed to the terminals of the solar cell, and is each capable of being stored in a retracted position and moved to an extended position.
US08382960B2 Arrangement for guiding a drill stem of a decoking tool
So-called decoking, in other words, the emptying of a container in which coke arising from the operation of a refinery is deposited and carried out using a decoking tool with a free mounting on the end of a drilling bar. The mounting is achieved using a sliding guide on a guide plate, coupled to the container. Distortions in the container and the guide plate therewith as a result of temperature variations during operation of the refinery which could lead to function disturbance of the drilling rod are avoided, wherein the sliding guide and the guide plate are arranged with a spring relative deflection by at least one spring element in the manner of a spring damper.
US08382958B2 Cyclic batch coal devolatilization apparatus
Apparatus and a process are described for compressing superheated steam into porous coal batches in chambers, and, after a time interval, expanding this steam out of the chambers, and repeating this steam cycle of compression followed by expansion. Thusly heated by the steam, volatile matter separates from the solid coke portion of the coal and separate volatile matter and coke products can be produced from coal or biomass fuels. These volatile matter liquids and tars can be used as fuel components in slurry fuels, for internal combustion engines used in our surface transportation industries. These solid coke products can be used as boiler fuel in steam electric plants. In this way our large domestic reserves of coal can be used as a fuel source, not only for electric power generation, but also for our surface transportation needs.
US08382955B2 Method for operating a sheet-forming unit, and sheet forming unit
A method for operating a sheet-forming unit of a papermaking machine. At least one fibrous material suspension is fed to a headbox and is conducted in a plurality of turbulence-generating channels to form sub-flows, and fed to a nozzle. From the nozzle, the at least one fibrous material suspension is in the form of a free jet into the forming unit to define an impingement line. In a final fluidization region of an individual turbulence-generating channel a pressure loss (Δp) of ≧50 mbar is generated within the fibrous material suspension before inlet thereof into the nozzle, and the fibrous material suspension is guided from the final fluidization region as far as the impingement line in such a way that the dwell time of the suspension in the region defined by the final fluidization region as far as the impingement line ranges from >30 ms to ≦300 ms.
US08382952B2 Wet-end manufacturing process for bitumen-impregnated fiberboard
A process for manufacturing fiberboard by preparing a fiber slurry mixture including containing cellulose fibers and water then atomizing a liquid bituminous material, such as asphalt. The liquid bituminous material is atomized by mixing it with a pressurized gas, such as compressed air, forming a mist comprising droplets of bituminous material having a diameter between 20 microns and 50 microns. A water spray solidifies the bituminous material droplets thereby forming bituminous particles which fall into the fiber slurry within the spray chamber. From there the slurry is sheared, dewatered, and dried, forming a finished fiberboard.
US08382949B2 Paper substrates useful in wallboard tape applications
A paper substrate, particularly useful in wallboard tape applications containing PVOH on and/or in at least one surface of the paper, as well as methods of making and using the same. The use of the tape of the invention is used in conjunction with a joint compound that may contain no or reduced amounts of bonding agent.
US08382943B2 Method and apparatus for the selective separation of two layers of material using an ultrashort pulse source of electromagnetic radiation
A direct-write method, apparatus and end use device for selective separation of at least one layer of material from another layer of material at the interface between them using a beam of electromagnetic radiation from an ultrashort pulse source is disclosed.
US08382940B2 Device and method for producing chlorine trifluoride and system for etching semiconductor substrates using this device
A device (6) and a method for generating chlorine trifluoride is described, a high-density plasma (105) being generated in the interior of a plasma reactor (100) using plasma generating means (110, 120, 130, 150, 155, 160, 170, 180), and a first gas and a second gas, which react with one another under the influence of the high-density plasma (105) in the plasma reactor (100) under the formation of chlorine trifluoride, being supplied to the plasma reactor (100) via gas supply means (21, 22, 25, 26). In addition, a gas outlet (20) is provided, via which the generated chlorine trifluoride can be removed from the plasma reactor (100). Finally, a system (5) for etching semiconductor substrates (30), silicon wafers in particular, is described including such an upstream device (6), the system (5) having a process chamber (10) which is connected to the plasma reactor (100) via the gas outlet (20), and the semiconductor substrate (30) being situated in the process chamber (10) and exposed to the gaseous chlorine trifluoride generated by the device (6).
US08382938B2 Gate valve cleaning method and substrate processing system
A gate valve cleaning method that can clean a gate valve that brings an atmospheric transfer chamber and an internal pressure variable transfer chamber that transfer a substrate into communication with each other or shuts them off from each other without bringing about a decrease in the throughput of a substrate processing system. Before the gate valve brings the atmospheric transfer chamber and the internal pressure variable transfer chamber into communication with each other, the pressure in the internal pressure variable transfer chamber is increased so that the pressure in the internal pressure variable transfer chamber can become higher than the pressure in the atmospheric transfer chamber.
US08382937B2 Laminating adhesives based on triglyceride-derived polyols
Natural oils, fats and other fatty acid triglycerides are transesterified with polyalcohols such as trimethylolpropane or glycerol to yield polyhydroxyl-functionalized reaction products which are useful materials in the formulation of two component laminating adhesives.
US08382936B2 Aqueous biopolymer-containing labeling adhesive
Adhesives particularly useful for industrial bottle labeling are provided. The adhesives comprise at least one starch component and at least one protein component (which is not gelatin or casein). The adhesive is also free of synthetic polymer. The label, along with the adhesive, can be easily removed from the bottle during the recycling process. In one embodiment, the starch component does not contain leguminous starch having an amylose content of 25% or more. In another embodiment, the adhesive comprises a crosslinking agent.
US08382934B2 Method for manufacturing electronic component
A triaxial acceleration sensor which has a structure including a cover joined to a substrate including a mechanically operable functional unit to be sealed, is adapted in such a way that the joined state can be reliably obtained so as to not interfere with a displacement of the functional unit. A sealing frame is made of a heated polyimide on a periphery of an upper main surface of a substrate provided with a functional unit, and a sealing layer made of a polyimide is formed over an entire lower main surface of a cover. For integrating the substrate and the cover so as to seal the functional unit, the sealing frame and the sealing layer are joined to each other by heating and pressurizing the sealing frame and the sealing layer at a temperature that is about 50° C. to about 150° C. higher than a glass transition temperature of the polyimide while bringing the sealing frame and the sealing layer into contact with each other. In this case, a recess is formed in the vicinity of a portion of the sealing layer to be brought into contact with the sealing frame so that a bump, generated from the sealing layer which is deformed in the joining step, is prevented from protruding toward the functional unit.
US08382931B2 Method of manufacturing a catheter having an expandable member
A method for manufacturing a catheter includes preparing raw materials and maturing the raw materials in a drier at 50-55° C. for 20 days, preparing the expandable member, and the first and second tubes, in forms, by cutting the raw materials, fitting an index ring on the second tube, welding the expandable member to the first tube, and welding the expandable member with the second tube, connecting the first tube to a first side of the manifold, and connecting the second tube to a second side of the manifold, forming a shape and a size of the expandable member, and drying an interior of the expandable member and the second tube and maturing the expandable member for 24 hours in the drier at 50-55° C., then for 48 hours in the drier at 50-55° C.
US08382928B2 Method for manufacturing pants-type diaper
A method for manufacturing a pants-type diaper of the present invention includes: a step of carrying a diaper body in a longitudinal direction X; a first folding step of folding a side panel 3 along a first line L1 extending in the longitudinal direction; a first attachment step of attaching first end portions 31 of a pair of side panels 3 to end portions 20a (21a), opposing each other in a girth direction Y, of the front portion 20 or the back portion 21; a second folding step of folding the diaper body 2 along a second line L2 extending along the girth direction Y so that the front portion 20 and the back portion 21 lie on each other; and a second attachment step of attaching second end portions 32 of the pair of side panels 3 to end portions, opposing each other in the girth direction Y, of the back portion 21 or the front portion 20, to which the side panel 3 has not been attached in the first attachment step.
US08382924B2 Multi-stage debulk and compaction of thick composite repair laminates
A method for fabricating a repair laminate for a composite part having an exposed surface includes applying a release film to the exposed surface and forming an uncured ply stack assembly on the release film. The uncured ply stack assembly is formed by forming and compacting a series of uncured ply stacks. The release film and ply stack assembly is then removed from the exposed surface. A bonding material is then applied to the exposed surface, and the uncured ply stack assembly is applied to the bonding material. The ply stack assembly and bonding material are then cured.
US08382917B2 Hyperelastic shape setting devices and fabrication methods
Shape-setting methods for fabricating devices made of single crystal shape memory alloys. In particular the methods described may be used to fabricate dental arches of single-crystal shape memory alloys. The methods include drawing a single crystal of a shape memory alloy from a melt of the alloy. This is followed by heating, forming, and quenching the crystal sufficiently rapid to limit the formation of alloy precipitates to an amount which retains hyperelastic composition and properties of the crystal.
US08382915B2 Concrete mixer drum cleaner
The present invention is a concrete mixer drum cleaner system. The system has a multi-axis spray head mounted to a lance. One of the spray head's axes of rotation is coaxial with the lance. An operator uses the lance to position the spray cleaner head within the interior of a concrete mixer drum.
US08382914B2 Dishwasher with comminution device
A dishwasher is provided with a washing container for receiving items to be washed by the dishwasher, a circulatory pump for circulating a rinsing liquid into contact with items received in the washing container, and a comminution device for comminuting rinsing residue. The comminution device and the circulatory pump are operatively interconnected in a manner such that the comminution device is at least temporarily driven by the circulatory pump. As a result, the comminution device can be driven in a simple and efficient manner, enabling the dishwasher to be produced at low cost and also increasing the reliable operability and easy maintenance thereof.
US08382909B2 Use of spectroscopic techniques to monitor and control reactant gas input into a pre-pump reactive gas injection system
The present invention relates to vacuum processing systems in which process gases are introduced in a process chamber and are exhausted through a vacuum processing system exhaust path. Deposits made by the exhausted gas are reduced or eliminated by introducing a reactive gas upstream of the device affected by deposits. The amount of introduced reactive gas is controlled by measuring gas phase concentrations of exhausted gas components upstream and downstream of the affected device, and, from those measurements, determining whether the components are being consumed in deposits on the affected device.
US08382908B2 Methods for cleaning endotracheal tubes
Systems, devices, and methods are disclosed for the cleaning of an endotracheal tube while a patient is being supported by a ventilator connected to the endotracheal tube for the purpose of increasing the available space for airflow or to prevent the build up of materials that may constrict airflow or be a potential nidus for infection. In one embodiment, a method for cleaning endotracheal tubes comprises inserting a cleaning device within an endotracheal tube while a cleaning member is in a compressed position, radially expanding the cleaning member to an expanded position within the endotracheal tube, and withdrawing the cleaning device from the endotracheal tube with the cleaning member in the expanded position.
US08382907B2 System and method for cleaning a grinding machine
A grinding machine cleaning system and method provides a range of human safe products that can easily be introduced into the grinding chamber and cycled through the equipment. Some of the products include corn cobs, walnut shells, pecan shells, nuts, rice, dried corn kernels, corn meal, barley, wheat, bulgur, and other grain, fiber, legume, nut, bark, and shell products in varying shapes and sizes. Organic products have largely been considered ideal. However, inorganic materials also may be used with equal effect.
US08382905B2 Plant-fiber-material transformation method
Cellulose contained in plant fiber material is hydrolyzed with the use of a pseudo-molten cluster acid as a hydrolysis catalyst to produce saccharide, most of which is glucose. After the glucose is produced, the saccharide is precipitated with the use of an organic solvent, and the saccharide including a solidified saccharide during the hydrolysis and the precipitated saccharide is separated from residues and the cluster acid.
US08382903B2 Vaporizer and semiconductor processing system
A vaporizer for generating a process gas from a liquid material includes a container defining a process space of the vaporizer, and an injector having a spray port configured to spray the liquid material in an atomized state downward in the container. A lower block is disposed below the spray port inside the container such that a run-up space for the atomized liquid material is defined between the spray port and the lower block, and an annular space continuous to the run-up space is defined between an inner surface of the container and the lower block. First and second heaters are respectively provided to the container and the lower block, and configured to heat the atomized liquid material flowing through the annular space to generate the process gas. A gas delivery passage is connected to the container to output the process gas from the annular space.
US08382899B2 Method and mould for casting articles with a pre-determined crystalline orientation
Previously a number of techniques have been used in order to form single crystal or pre-determined crystallography components and articles. Each one of these techniques has its own particular problems, including susceptibility to error. By utilization of a bi-crystal experiment to determine melt-back length LM and by consideration of the ingress distance d from potential initiation nucleation points on a perimeter of a seed crystal, it is possible to determine a maximum ingress length d. By ensuring that the maximum ingress length d is less than or equal to a seed crystal diameter R, it is possible to project locus from potential nucleation points C1, C2 in terms of potential radii for stray grain propagation. As the seed crystal will have a known crystalline orientation, it will be possible to consider two divergent growth curves of the crystal in terms of the stray grains propagating from the point C1, C2. In such circumstances, a connector channel can be provided with a radius r=R/4 in an area between the periphery of the seed and the locus of the stray grain maximum ingress distances d. In situations where it is found d exceeds the crystal radius R, it will be understood that the actual crystal diameter R used may be increased or adjustment made with regard to the melt-back length LM in order to alter the maximum ingress distance d.
US08382897B2 Process gas delivery for semiconductor process chambers
Methods for gas delivery to a process chamber are provided herein. In some embodiments, a method may include flowing a process gas through one or more gas conduits, each gas conduit having an inlet and an outlet for facilitating the flow of gas through the gas conduits and into a gas inlet funnel having a second volume, wherein each gas conduit has a first volume less than the second volume, and wherein each gas conduit has a cross-section that increases from a first cross-section proximate the inlet to a second cross-section proximate the outlet but excluding any intersection points between the gas inlet funnel and the gas conduit, and wherein the second cross-section is non-circular; and delivering the process gas to the substrate via the gas inlet funnel.
US08382895B2 Silicon single crystal manufacturing method, silicon single crystal, silicon wafer, apparatus for controlling manufacture of silicon single crystal, and program
A method of manufacturing a silicon monocrystal by FZ method, wherein a P-type or N-type silicon crystal having been pulled up by CZ method is used as a raw material. While impurities whose conductivity type is the same as that of the raw material are supplied by a gas doping method, the raw material is recrystallized by an induction-heating coil for obtaining a product-monocrystal.
US08382893B1 Cementitious compositions
A cementitious composition is formed from a dry mix including a quantity of cement; a quantity of silica and a plurality of fibers. The cementitious composition further includes a quantity of water and a complex admixture of cement additives. The complex admixture includes superplasticizer, shrinkage reduction agent and a non-ionic surfactant in a predetermined quantity per hundred pounds of dry mix.
US08382889B1 Dendritic starch-based dextrin adhesives
A modified starch-based adhesive including a starch-based adhesive and an additive, the additive including a dendron, a sugar unit bound to the dendron, and an antimicrobial agent bound to the dendron and, a method of synthesizing the additive including providing a dendron, binding a linker molecule to the dendron, binding a sugar unit to the linker molecule, and binding an antimicrobial agent to the linker molecule.
US08382885B2 Fluid filtration for substrate processing chamber
A filter for filtering a fluid in a substrate processing apparatus comprises first and second stages that are connected to one another. A delivery system provides a vaporized liquid to the filter. The first stage of the filter comprises a basic compound, and the second stage of the filter comprises a desiccant. A second filter comprises a permeation filter with permeable membrane to filter the fluid. Methods of filtering the fluid to reduce formation of undesirable process residues using the filter(s) are also described.
US08382884B2 Particulate matter detection device
A PM sensor is provided having high responsiveness and capable of long term detection. A PM sensor includes a sensor element that has particulate collection electrodes to which a particulate collection voltage for causing particulate matter contained in exhaust to adhere to a sensor element is applied, and measurement electrodes to which a measurement voltage for measuring an electrical characteristic of the sensor element is applied, in which, after a particulate collection voltage is applied to the particulate collection electrodes application of the particulate collection voltage is stopped in response to a predetermined condition being satisfied, the measurement voltage is applied to the measurement electrodes and the electrical characteristic of the sensor element is measured.
US08382883B2 Membranes comprising amino acid mobile carriers
In one aspect, the present invention provides a curable composition useful in the preparation of a gas separation membrane. The curable composition comprises a polyvinyl alcohol; an aliphatic polyamine; a polyglycidyl ether; and a salt of a C2 to C4 heterocyclic amino acid. In another aspect the present invention provides a composition comprising a crosslinked polyvinyl alcohol comprising structural units derived from a polyglycidyl ether, a polyamine and the salt of a C2 to C4 heterocyclic amino acid. The compositions are useful in the preparation of gas separation membranes in which the C2 to C4 heterocyclic amino acid in the form of its salt functions as a mobile carrier of carbon dioxide.
US08382880B2 Method for solubilizing molybdenum oxide concentrates
A process for digesting molybdenum oxide concentrates includes suspending a molybdenum-containing starting material in an aqueous solution so as to obtain a suspension. While stirring, an oxidizing agent and an alkali solution of at least one alkali metal are metered to the suspension so as to set a pH and produce a product having a molybdenum content of at least 98% of the molybdenum-containing starting material. The alkali metal is selected from the group consisting of Na, K and Li.
US08382879B2 Copper smelting method
A copper smelting method includes: supplying an oxygen-enriched gas, a solvent, and a copper concentrate into a furnace, while not supplying a coke material; and supplying pig iron to slag that is generated in the furnace.
US08382874B2 Air filter having dimensional extending tabs
There is provided herein an air filter that includes one or more foldable extension flaps that can be folded and secured against the frame to provided an extend thickness dimension for the frame of the air filter, which allows the same filter to be used in either a smaller or larger filter slot within an HVAC system.
US08382869B2 System and method for removal of particulate matter from a filter media
A particulate filtration reverse pulse cleaning system is disclosed. The system comprising a housing, a tubesheet disposed within the housing, a filter for fluid communication with a tubesheet aperture, a support frame connectable with the tubesheet, and a cleaning system associated with the support frame. A filter cleaning system is also disclosed, the support frame comprising a plurality of hollow support legs comprising at least one cleaning aperture and a cleaning system associated with the plurality of hollow support legs. A method for cleaning a filter is also disclosed.
US08382867B2 Systems and methods for producing substitute natural gas
Systems and methods for producing synthetic natural gas are provided. The method can include gasifying a carbonaceous feedstock within a gasifier to provide a raw syngas. The raw syngas can be cooled to provide a cooled raw syngas. The cooled raw syngas can be processed in a purification system to provide treated syngas. The purification system can include a flash gas separator in fluid communication with the gasifier and a saturator. The treated syngas can be converted to synthetic natural gas to provide steam, a methanation condensate, and a synthetic natural gas. The methanation condensate can be introduced to the flash gas separator.
US08382865B2 Reaction apparatus, fuel cell system and electronic device
The invention relates to a reaction apparatus having an enhanced connection, and a fuel cell system and an electronic device that include such a reaction apparatus. A reaction apparatus (1) a reformer (4) in which a reforming reaction chamber (31) is formed, a CO remover in which a removing reaction chamber (35) where a chemical reaction is performed at a temperature lower than that in the reforming reaction chamber (31) is formed, and a connecting portion (6) having a communicating path that communicates between the reforming reaction chamber (31) and the removing reaction chamber (35). The reformer (4) and the CO remover (5) are arranged spaced apart from each other, at least one of which (4, 5) is configured by combining ceramic parts (11, 12) and metal components (15, 16), and the ceramic parts (11, 12) and the metal components (15, 16) are connected with connecting members (18, 20) interposed therebetween. The connecting members (18, 20) have thermal conductivities higher than those of the ceramic parts (11, 12).
US08382863B2 Engineered fuel feed stock
Disclosed are novel engineered fuel feed stocks, feed stocks produced by the described processes, and methods of making the fuel feed stocks. Components derived from processed MSW waste streams can be used to make such feed stocks which are substantially free of glass, metals, grit and noncombustibles. These feed stocks are useful for a variety of purposes including as gasification and combustion fuels.
US08382861B2 Method of producing a gel polymer Li-ion battery
The invention relates to a composite gel polymer Li-ion battery and its producing method. The Li-ion battery cell includes a three-layer composite layer of positive electrode current collector, positive electrode active material and gel polymer electrolyte obtained by a two-layer one-step coating process; a two-layer composite layer of negative electrode current collector and negative electrode active material obtained by a single-layer coating process or a negative electrode two-layer composite layer coated with a little polyurethane adhesive(s) on the surface. The gel polymer Li-ion battery cell is obtained by laminating the resultant two composite layers. The gel polymer Li-ion battery cell has a small thickness and a compact structure, and is laminated closely and easy for preparation and industrial automatic production. The Li battery prepared by the method has a uniform structure, a low internal resistance, a high uniformity, a good unity, and a high safety.
US08382849B2 Porous titanium tibial sleeves and their use in revision knee surgery
The invention concerns monolithic foam sleeves that comprises titanium or titanium alloy foam having a porosity of 50 to 85% and possesses a proximal surface, a distal end, an interior wall that defines an interior channel and extends from the proximal surface to the distal end; and a terraced outer surface that tapers such that said sleeve is widest at the proximal surface and most narrow at the distal end.
US08382847B2 Posterior stabilized knee with varus-valgus constraint
A femoral component of a knee prosthesis has spaced condyle surfaces defining a notch therebetween. The notch defines an elongated cam housing having an anterior cam and a posterior cam at opposite ends of the housing. The tibial component of the knee prosthesis includes a platform and a bearing supported on the platform, the bearing defining bearing surfaces configured to articulate with the condyle surfaces. The tibial component includes a spine projecting superiorly from the bearing that defines an anterior face and a posterior face. The posterior face and the posterior cam define complementary curved surfaces configured for cooperative engagement when the femoral component and the tibial component are at a predetermined flexion angle. The cam housing is configured to form a gap between the posterior cam and the spine when the knee is normally extended. In another feature, the spine includes a stiffening pin extending therethrough.
US08382843B2 Intervertebral implant with blades for connecting to adjacent vertebral bodies
An intervertebral implant (300) for insertion into an intervertebral disc space between adjacent vertebral bodies or between two bone portions. The implant includes a spacer portion (310), a plate portion (330) operatively coupled to the spacer portion and one or more blades (350) for securing the implant to the adjacent vertebral bodies. The blades preferably include superior and inferior cylindrical pins (360) for engaging the adjacent vertebral bodies. The implant may be configured to be inserted via a direct lateral transposals approach. Alternatively, the implant may be configured for insertion via an anterior approach.
US08382840B2 Spinal implant delivery methods and devices
Systems and methods for implanting a spinal implant in a spinal column are disclosed. In one example, an illustrative system may include a delivery device including a proximal end region and a distal end region, a spinal implant releasably coupled to the distal end region of the delivery device, and a sleeve disposed about the spinal implant and at least a portion of the delivery device. In some cases, a distal portion of the sleeve may include a predetermined weakened region that may be configured to separate when a force is applied to the weakened region, which in some cases, may be applied with a pull string. In another example, a distal portion of the sleeve may be reverse folded upon itself such that the retractable sleeve rolls off of the spinal implant when the retractable sleeve is retracted.
US08382835B2 Apparatus and method for manipulating a flexible strand and soft tissue replacement during surgery
An apparatus and method is disclosed for performing a surgery, such as an orthopedic surgery. The apparatus can include a guide portion and an alignment portion. The guide portion can assist in positioning the alignment portion to assist in aligning an implant. The implant can be aligned and positioned to hold a graft relative to a bone portion.
US08382832B2 Foldable intraocular lens and method of making
A foldable intraocular lens for providing vision contains an optic body that includes an optical zone and a peripheral zone entirely surrounding the optical zone. The optic body has an anterior face, a substantially opposing posterior face, an optic edge, and an optical axis. The anterior face comprises a central face, a peripheral face, and a recessed annular face therebetween that is disposed posterior to the peripheral face. The intraocular lens further comprises at least one haptic that is integrally formed with the peripheral zone. The haptic comprises a distal posterior face, a proximal posterior face, and a step edge disposed at a boundary therebetween. The haptic further comprises a side edge disposed between the optic edge and the step edge. The proximal posterior face and the posterior face of the optic body form a continuous surface. An edge corner is formed by the intersection of the continuous surface with the optic edge, the side edge, and the step edge.
US08382831B2 Method and apparatus for anchoring an intraocular lens assembly
An intraocular lens assembly for implantation in the posterior chamber of an eye has anchor portions with teeth rigid enough to penetrate the scleral wall of an eye. A method for implanting the lens includes the steps of: introducing the first haptic portion with a first anchor portion that includes a plurality of teeth projecting therefrom, into the posterior chamber of the eye until said teeth are anchored in the scleral wall at a desired location; and moving a second haptic portion with a plurality of teeth projecting therefrom, until said teeth are anchored in the scleral wall on the opposite side of the lens from the first anchor portion.
US08382829B1 Method to reduce mitral regurgitation by cinching the commissure of the mitral valve
Methods of repairing the mitral valve and reducing mitral regurgitation. One method includes securing a first tissue anchor to a position on a posterior portion of the annular tissue of the mitral valve and a second tissue anchor to a position on an anterior portion of the annular tissue of the mitral valve. At least one tensile member spans between the first and second tissue anchors and across the orifice of the mitral valve. When tension is applied to the at least one tensile member, the posterior portion of the annular tissue is pulled toward the anterior portion.
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