| Document | Document Title |
|---|---|
| US08319391B2 |
Flux-concentrating stator assembly
A stator assembly for an electric motor includes an annular core centered about an axis of rotation of an inner rotor which the stator assembly surrounds. The stator assembly has a plurality of electrical windings, each wound in a respective spiral around the outer surface of the core and arranged for current to flow in the windings. In some embodiments, the respective spirals are spaced from and parallel with one another. The stator assembly may have pole pieces that substantially enclose the core and windings. The pole pieces may be configured to taper both radially outward and axially inward to thereby concentrate flux from the core to an inner surface of the pole pieces facing the rotor. |
| US08319389B2 |
Segmented stator assembly
An electric machine and stator assembly includes a segmented stator having stator portions. Each stator portion includes stator laminations, end plates arranged axially on opposing sides of the stator portion, and structural plates arranged interior to the end plates. Each of the support plates has a portion with notch-like structures that is embedded within the stator laminations. Stabilizing couple the end plates and the structural plates together. Connectors are provided to connect the stator portions together. |
| US08319388B2 |
Induction motor and hermetic compressor
The present invention is directed to provide an induction motor having an ideal efficiency at the normal operation time, while obtaining a high locked-rotor torque without having to use a special drive circuit. According to the induction motor related to the present invention, the induction motor has a rotor 11 having a double squirrel-cage secondary conductor, wherein the rotors 11 includes a rotor core 11a formed by laminating a plurality of electromagnetic steel plates, outer layer slots 40a filled with conductive material, installed along an outer peripheral edge of the rotor core 11a, inner layer slots 40b filled with conductive material, disposed inside of the outer layer slot 40a in the radial direction, and inner peripheral thin bridges 82 made of electromagnetic steel plate, installed in between the outer layer slots 40a and the inner layer slots 40b. |
| US08319387B2 |
Rotor for use in IPM rotating electric machine, and IPM rotating electric machine provided with the rotor
A rotor includes a rotor core; and first permanent magnets and second permanent magnets arranged in the rotor core so that, on a cross-sectional plane of the rotor core perpendicular to the rotation axis thereof, the first and second magnets corresponding to each other define the letter V having an apex pointing toward the rotation axis. The first and second magnets corresponding to each other are arranged so that a straight line interconnecting the rotation axis and the apex of the letter V is interposed therebetween, an angle of the first magnet relative to the straight line being smaller than that of the second magnet relative to the straight line, a width of the first magnet in the direction parallel to the first side of the letter V being smaller than that of the second magnet in the direction parallel to the second side of the letter V. |
| US08319382B2 |
Electric motor having wire connection structure and wire connection method for the same
An electric motor includes a stator having a stator coil, a rotor, a motor housing having a through hole, a fixing portion extending from the stator within the motor housing towards the through hole, a load receiving member inserted into the through hole and having a through bore, a conductive member connected to an electric power supply wire member and arranged at a first end portion of the load receiving member, a first terminal connected to the stator coil and provided between a second end portion of the load receiving member and the fixing portion, and a screw bolt fixing the conductive member, the load receiving member and the first terminal on the fixing portion, so that the load receiving member is press-fixedly sandwiched by the conductive member and the first terminal so that an electric power flows therebetween via the load receiving member. |
| US08319380B2 |
Method of tuning bending and torsion stiffness of ducted rotor core of an induction motor
Electrodymamic machine rotating mass, including for example induction motor rotors, stiffness tuning methods include selective orientation and compression of modular tie rod assemblies into through bores formed in the rotor lamination core outboard of the rotor shaft during motor manufacture, repair or refurbishment. Stiffness tuning enables a motor manufacturer to tune a rotor's rotordynamic stability, and hence the assembled motor's critical vibration speed. Electrodynamic machine rotating mass tuning can be adjusted in response to machine physical design, operational application and manufacturing variation attributes that impact the assembled machine's critical vibration frequency. Thus the present invention offers a systematic, holistic approach to motor vibration refinement through use of a simple kit of modular tie rod assemblies oriented and tightened in a selected array. Rotor stiffness tuning can be tested virtually on computer work stations. Additional actual rotor stiffness tuning can be performed during manufacture. |
| US08319377B2 |
Fuse for disconnecting an inverter from a photovoltaic generator
A photovoltaic system includes an inverter, a photovoltaic generator with a plurality of serially connected photovoltaic modules, said photovoltaic generator connected to the inverter by an electrical supply line, a controllable fuse interconnected in the electrical supply line between the inverter and the photovoltaic generator and having a signal input, and a voltage-dependent resistor connected between the signal input of the controllable fuse and the electrical supply line and generating a control signal which triggers the controllable fuse responsive to the control signal and interrupts the electrical supply line. The controllable fuse can be used to disconnect the electrical connection of the photovoltaic system to the inverter when a switch short-circuiting one or more modules of the photovoltaic generator malfunctions. The arrangement permits operation of photovoltaic system at an operating voltage of close to 1000 V, thereby allowing use of thinner cables. |
| US08319373B2 |
System, socket and plug apparatus for DC power distribution and usage
A power supply system comprises an electrical power generating device producing DC electrical power in the form of a DC electrical current, a DC current conductor receiving the DC electrical current from the electrical power generating device and carrying the DC electrical current to a socket, and an AC power system transmitting AC electrical current to the socket so that the socket can be accessed by a plug inserted therein to receive the DC current or the AC current from it. The socket has four recesses in it, and each recess has a respective contact therein. Each recess is configured to receive a respective prong and make a respective electrical contact with the plug therein. A first of the contacts transmits the DC current, a second and third of the contacts transmit complementary poles of the AC electrical current, and a fourth contact connects with a grounded connection. A DC-powered electrical device has a plug with a plug body and three prongs supported on and extending from the plug body. The prongs include two AC connection prongs and a ground connection prong corresponding to prongs of a standard three-prong plug. The plug further has a fourth prong supported on the plug body into the socket to contact the DC current recess. The fourth prong is removable from the plug body, or is movably supported on the plug body so that the fourth prong may be removed or moved so that the plug can be plugged into a standard three-recess AC socket. |
| US08319370B2 |
Grid interconnection device and power control system
A grid interconnection device 100 comprises a receiver configured to receive an adjustment instruction and a controller configured to control a backward flow power on the basis of the adjustment instruction. The adjustment instruction includes group information indicating an application group to which the adjustment instruction is applied among a plurality of groups G. Customers 30 (each includes a power supply device) are grouped depending on the distance from a substation. |
| US08319367B2 |
Fluid whirl lighting apparatus
This disclosure provides a fluid whirl lighting apparatus, which comprises: a housing; a coil module, disposed on an inner wall of the housing; a rotor, disposed in the housing, provided with a plurality of blades on an inner wall thereof and a magnetic module on an outer wall corresponding to the coil module; a lighting module, disposed on the outer wall of the housing while electrically coupled to the coil module; and an alarm element, electrically connected to the coil module for issuing an alarm; wherein the outer wall of the rotor and the inner wall of the housing define an air-tight space for accommodating a liquid, and the rotor is rotated by a flowing fluid propelling the plural blades for enabling a relative movement between the coil module and the magnetic module for generating electricity; and the lighting module is used for providing illumination in response to the electricity. |
| US08319365B2 |
System and method to provide constant speed mechanical output in a machine
A system to provide constant speed mechanical output in a wind turbine is provided. The system includes at least one electrical machine configured to convert a rotary mechanical power received from a main gear to a machine electrical power. The system further includes one or more electrical converters electrically coupled to the machine and configured to convert the machine electrical power from a direct current (DC) power to an alternate current (AC) power or from the alternate current (AC) power to the direct current (DC) power, where the converters generate a differential electrical power. A torque converter is electrically coupled to the electrical converters and generates a constant speed mechanical output employing the differential electrical power received from the one or more electrical converters. |
| US08319362B2 |
Wind power turbine with a cooling system
A wind power turbine having a pylon; a nacelle; an electric generator fitted to the nacelle to produce electric energy; a frequency converter housed inside the pylon; and a cooling system for cooling the frequency converter, and which has an open-loop circuit provided with a conduit, and at least one cooling fin thermally connected to the frequency converter and housed in the conduit. |
| US08319361B2 |
Collision warning system for a wind energy installation
The invention relates to a device for monitoring a wind energy installation (1) comprising a tower (2) and a rotor provided with rotor blades (5) and arranged on the tower, in terms of a possible collision of a rotor blade (5) with the tower (2). Said device comprises at least one distance sensor (7a, 7b) which is arranged on the wind energy installation (1) and used for the non-contact measurement of the distance between the rotor blades (5) and a pre-determined point on the wind energy installation (1). The device also comprises an electronic evaluation system in which the distance data measured by the at least one distance sensor (7a, 7b) is evaluated, said system emitting a collision warning in the event of a critical distance not being reached. |
| US08319359B2 |
Device for wave-powered generator
A device for a wave-powered generator which is provided with at least one energy generator and lines for transferring energy to a consumer, the wave-powered generator comprising a main module provided with a running rod which is substantially vertical in its longitudinal extent, several supporting devices arranged around a portion of the running rod and arranged for sliding or rolling movement on surface portions extending in the longitudinal direction of the running rod, at least one sheave which is arranged to roll on the running rod, and transmission means which are arranged to translate the rotating motion of the at least one sheave into rotation of the drive shaft of the at least one generator; and a first float which is floatingly disposed in an area affected by waves and which is connected to the running rod by a primary driving line substantially of tensile strength. |
| US08319358B2 |
Electric vehicle charging methods, battery charging methods, electric vehicle charging systems, energy device control apparatuses, and electric vehicles
Electric vehicle charging methods, battery charging methods, electric vehicle charging systems, energy device control apparatuses, and electric vehicles are described. In one arrangement, an electric vehicle charging method includes receiving information regarding charging of an electric vehicle with energy from an electric power grid, determining an amount of energy stored by an energy storage device coupled to the electric power grid, and controlling a transfer of the energy stored by the energy storage device to the electric power grid using the information regarding the charging of the electric vehicle. Other arrangements are described. |
| US08319356B2 |
System for starting power systems with multiple generator units
A control system and strategy for starting power systems having a plurality of power modules. For example, a multi-engine generator set switcher locomotive has three power modules each of which have an engine associated therewith. Upon receiving a command from the locomotive indicating to the engine control module to start at least one power module, i.e., engine, the control strategy determines whether to start the engine with an air or electric start. The control strategy starts only a single engine at a time, thereby avoiding overloading the airflow capacity of the compressed air source or the electric power capacity of the electric source. The control strategy also implements a command to start every engine with an air starter, if possible, to preserve the electric starter motor and the electric power capacity of the electric source. |
| US08319354B2 |
Semiconductor chip with post-passivation scheme formed over passivation layer
The invention provides a semiconductor chip comprising an interconnecting structure over said passivation layer. The interconnecting structure comprises a first contact pad connected to a second contact pad exposed by an opening in a passivation layer. A metal bump is on the first contact pad and over multiple semiconductor devices, wherein the metal bump has more than 50 percent by weight of gold and has a height of between 8 and 50 microns. |
| US08319351B2 |
Planar multi semiconductor chip package
Provided are a planar multi semiconductor chip package in which a processor and a memory device are connected to each other via a through electrode and a method of manufacturing the planar multi semiconductor chip package. The planar multi semiconductor chip package includes: a substrate comprising a plurality of first circuit patterns on a first surface and a plurality of second circuit patterns on a second surface; a first semiconductor chip comprising a plurality of memory devices arranged on the substrate, wherein first memory devices surround at least a portion of second memory devices; a second semiconductor chip stacked on the first semiconductor chip and corresponding to the second memory devices; and a plurality of through electrodes arranged on the second memory devices and connecting the first and second semiconductor chips to the second circuit pattern of the substrate. |
| US08319343B2 |
Routing under bond pad for the replacement of an interconnect layer
The present invention provides a solder bump structure. In one aspect, the solder bump structure is utilized in a semiconductor device, such as an integrated circuit. The semiconductor device comprises active devices located over a semiconductor substrate, interconnect layers comprising copper formed over the active devices, and an outermost metallization layer positioned over the interconnect layers. The outermost metallization layer comprises aluminum and includes at least one bond pad and at least one interconnect runner each electrically connected to an interconnect layer. An under bump metallization layer (UBM) is located over the bond pad, and a solder bump is located over the UBM. |
| US08319340B2 |
Lead frame and method of manufacturing the same
A lead frame having improved connectivity with a molded portion and a method of manufacturing the lead frame are provided. The lead frame includes a die pad on which a semiconductor chip is to be disposed; at least one lead portion arranged to be connected to the semiconductor chip; and at least one plating layer formed on at least one of the at least one lead portion and the die pad, wherein a top surface of the at least one plating layer has an uneven portion having a first average surface roughness. |
| US08319339B2 |
Surface-mounted silicon chip
A silicon chip surface mounted via balls attached to its front surface, wherein the front and rear surfaces of the chip are covered with a thermosetting epoxy resin having the following characteristics: the resin contains a proportion ranging from 45 to 60% by weight of a load formed of carbon fiber particles with a maximum size of 20 μm and with its largest portion having a diameter ranging between 2 and 8 μm, on the front surface side, the loaded resin covers from 45 to 60% of the ball height, on the rear surface side, the loaded resin has a thickness ranging between 80 and 150 μm. |
| US08319334B2 |
Embedded laminated device
An electronic device includes at least one semiconductor chip, each semiconductor chip defining a first main face and a second main face opposite to the first main face. A first metal layer is coupled to the first main face of the at least one semiconductor chip and a second metal layer is coupled to the second main face of the at least one semiconductor chip. A third metal layer overlies the first metal layer and a fourth metal layer overlies the second metal layer. A first through-connection extends from the third metal layer to the fourth metal layer, the first through-connection being electrically connected with the first metal layer and electrically disconnected from the second metal layer. A second through-connection extends from the third metal layer to the fourth metal layer, the second through-connection being electrically connected with the second metal layer and electrically disconnected from the first metal layer. |
| US08319333B2 |
Power semiconductor module
In the power semiconductor module, a wiring metal plate electrically connects between power semiconductor elements joined to the circuit pattern, and between the power semiconductor elements and the circuit pattern. Cylindrical main terminals are joined, substantially perpendicularly, to the wiring metal plate and the circuit pattern, respectively. A cylindrical control terminal is joined, substantially perpendicularly, to one of the power semiconductor elements. |
| US08319331B2 |
Semiconductor device
Disclosed is a semiconductor device having improved heat dissipation efficiency. The semiconductor device includes a silicon interposer having a first surface and a second surface opposite the first surface. A plurality of semiconductor chips are provided on the first surface side of the silicon interposer. The silicon interposer has a plurality of via holes extending from the first surface to the second surface. An N type semiconductor and a P type semiconductor constituting a Peltier element are provided in each two of the via holes. |
| US08319330B2 |
Semiconductor package having exterior plating films formed over surfaces of outer leads
A semiconductor device having an improved whisker resistance in an exterior plating film is disclosed. The semiconductor device includes a tab with a semiconductor chip fixed thereto, plural inner leads, plural outer leads formed integrally with the inner leads, a plurality of wires for coupling electrode pads of the semiconductor chip and the inner leads with each other, and a sealing body for sealing the semiconductor chip. The outer leads project from the sealing body and an exterior plating film, which is a lead-free plating film, is formed on a surface of each of the outer leads. In the exterior plating film, the number of grains not larger than 1 μm in diameter and present on an interface side in the thickness direction of the exterior plating film is larger than the number of grains not larger than 1 μm and present on a surface side of the exterior plating film, whereby the difference in linear expansion coefficient between the exterior plating film and the outer lead is made small, thus making it possible to suppress the growth of whisker. |
| US08319325B2 |
Intra-die routing using back side redistribution layer and associated method
A semiconductor die includes: a body portion with a plurality of circuit components, a front side including electrical couplings to the plurality of circuit components, a back side having a redistribution layer with a first electrical terminal coupled to the plurality of circuit components by a first through-silicon via, and a second through-silicon via electrically coupled to a third through-silicon via by a trace on the back side redistribution layer. Also, disclosed is a method of coupling circuit components on a die using through-silicon vias and a back side redistribution layer. |
| US08319324B2 |
High I/O semiconductor chip package and method of manufacturing the same
Provided are a high I/O semiconductor chip package in which a processor and a memory device are connected to each other via through electrodes and a method of manufacturing the high I/O semiconductor chip package. The high I/O semiconductor chip package includes: a substrate comprising a plurality of first circuit patterns on a first surface and a plurality of second circuit patterns on a second surface; a first semiconductor chip comprising a plurality of memory devices arranged on the substrate, each memory device being arranged in a matrix in chip regions partitioned by a scribe region; a second semiconductor chip stacked on the first semiconductor chip; and a plurality of through electrodes arranged along peripheral portions of the memory devices and connecting the first and second semiconductor chips to the second circuit patterns of the substrate. |
| US08319321B2 |
Leadless package for high current devices
Some exemplary embodiments of a direct contact leadless package and related structure and method, especially suitable for packaging high current semiconductor devices, have been disclosed. One exemplary structure comprises a first contact lead frame portion, a paddle portion, and an extended contact lead frame portion held together by a mold compound. A first semiconductor device is attached to a top side of the paddle portion and is enclosed by said mold compound, while a second semiconductor device is attached to a bottom side of said paddle portion and is in electrical contact with said the first semiconductor device. The extended contact lead frame portion is in direct electrical contact with the second semiconductor device without using a bond wire. Alternative exemplary embodiments may include additional extended lead frame portions, paddle portions, and semiconductor devices in various configurations. |
| US08319317B2 |
Mesa type semiconductor device and manufacturing method thereof
Problems with a conventional mesa type semiconductor device, which are deterioration in a withstand voltage and occurrence of a leakage current caused by reduced thickness of an insulation film on an inner wall of a mesa groove corresponding to a PN junction, are solved using an inexpensive material, and a mesa type semiconductor device of high withstand voltage and high reliability is offered together with its manufacturing method. A stable protection film made of a thermal oxide film is formed on the inner wall of the mesa groove in the mesa type semiconductor device to cover and protect the PN junction, and an insulation film having negative electric charges is formed to fill a space in the mesa groove covered with the thermal oxide film so that an electron accumulation layer is not easily formed at an interface between an N− type semiconductor layer and the thermal oxide film. With the structure described above, an influence of the positive electric charges in the thermal oxide film is weakened and an extension of a depletion layer into the N− type semiconductor layer at the interface with the thermal oxide film is secured. |
| US08319315B2 |
Bipolar junction transistor devices
A bipolar junction transistor (BJT) device including a base region, an emitter region and a collector region comprises a substrate, a deep well region in the substrate, a first well region in the deep well region to serve as the base region, a second well region in the deep well region to serve as the collector region, the second well region and the first well region forming a first junction therebetween, and a first doped region in the first well region to serve as the emitter region, the first doped region and the first well region forming a second junction therebetween, wherein the first doped region includes a first section extending in a first direction and a second section extending in a second direction different from the first direction, the first section and the second section being coupled with each other. |
| US08319314B2 |
Semiconductor device
A semiconductor device comprises a first base layer of a first conductivity type; a plurality of second base layers of a second conductivity type, provided on a part of a first surface of the first base layer; trenches formed on each side of the second base layers, and formed to be deeper than the second base layers; an emitter layer formed along the trench on a surface of the second base layers; a collector layer of the second conductivity type, provided on a second surface of the first base layer opposite to the first surface; an insulating film formed on an inner wall of the trench, the insulating film being thicker on a bottom of the trench than on a side surface of the trench; a gate electrode formed within the trench, and isolated from the second base layers and the emitter layer by the insulating film; and a space section provided between the second base layers adjacent to each other, the space section being deeper than the second base layers and being electrically isolated from the emitter layer and the second base layers. |
| US08319312B2 |
Devices for fabricating tri-layer beams
Methods and devices for fabricating tri-layer beams are provided. In particular, disclosed are methods and structures that can be used for fabricating multilayer structures through the deposition and patterning of at least an insulation layer, a first metal layer, a beam oxide layer, a second metal layer, and an insulation balance layer. |
| US08319309B2 |
Semiconductor device and method for manufacturing of the same
The present invention provides a semiconductor device including: a base substrate; a semiconductor layer which is disposed on the base substrate and has a 2-Dimensional Electron Gas (2DEG) formed therewithin; a first ohmic electrode disposed on a central region of the semiconductor layer; a second ohmic electrode which is formed on the edge regions of the semiconductor layer in such a manner to be disposed to be spaced apart from the first ohmic electrodes, and have a ring shape surrounding the first ohmic electrode; and a Schottky electrode part which is formed on the central region to cover the first ohmic electrode and is formed to be spaced apart from the second ohmic electrode. |
| US08319306B2 |
Method of fabricating image sensor and image sensor thereof
A method of fabricating an image sensor and an image sensor thereof are provided. The method comprises: providing a mask; utilizing the mask at a first position to form a first group of micro-lenses having a first height on a first group of color filters of a color filter array on a pixel array; shifting the mask from the first position to a second position, wherein a distance between the first position and the second position is substantially equal to a width of a pixel of the pixel array; and utilizing the mask at the second position to form a second group of micro-lenses having a second height, different from the first height, on a second group of color filters of the color filter array. |
| US08319301B2 |
Self-aligned filter for an image sensor
An image sensor includes at least one photosensitive element disposed in a semiconductor substrate. Metal conductors may be disposed on the semiconductor substrate. A filter may be disposed between at least two individual metal conductors and a micro-lens may be disposed on the filter. There may be insulator material disposed between the metal conductors and the semiconductor substrate and/or between individual metal conductors. The insulator material may be removed so that the filter may be disposed on the semiconductor substrate. |
| US08319298B2 |
Integrated circuit module
An integrated circuit module includes a carrier substrate, a semiconductor die disposed in the carrier substrate, a ground pad disposed on the carrier substrate, and an antenna partially embedded in the carrier substrate. The antenna includes a ground layer in thermal contact with the ground pad for dissipating heat generated from the semiconductor die. |
| US08319293B2 |
Semiconductor device and production method therefor
It is an object to allow an inverter to be made up using a single island-shaped semiconductor, so as to provide a semiconductor device comprising a highly-integrated SGT-based CMOS inverter circuit. The object is achieved by a semiconductor device which comprises an island-shaped semiconductor layer, a first gate dielectric film surrounding a periphery of the island-shaped semiconductor layer, a gate electrode surrounding a periphery of the first gate dielectric film, a second gate dielectric film surrounding a periphery of the gate electrode, a tubular semiconductor layer surrounding a periphery of the second gate dielectric film, a first first-conductive-type high-concentration semiconductor layer disposed on top of the island-shaped semiconductor layer, a second first-conductive-type high-concentration semiconductor layer disposed underneath the island-shaped semiconductor layer, a first second-conductive-type high-concentration semiconductor layer disposed on top of the tubular semiconductor layer, and a second second-conductive-type high-concentration semiconductor layer disposed underneath the tubular semiconductor layer. |
| US08319290B2 |
Trench MOS barrier schottky rectifier with a planar surface using CMP techniques
High Efficiency Diode (HED) rectifiers with improved performance including reduced reverse leakage current, reliable solderability properties, and higher manufacturing yields are fabricated by minimizing topography variation at various stages of fabrication. Variations in the topography are minimized by using a CMP process to planarize the HED rectifier after the field oxide, polysilicon and/or solderable top metal are formed. |
| US08319289B2 |
Power MISFET, semiconductor device and DC/DC converter
A technique for suppressing lowering of withstand voltage and lowering of breakdown resistance and reducing a feedback capacitance of a power MISFET is provided. A lateral power MISFET that comprises a trench region whose insulating layer is formed shallower than an HV-Nwell layer is provided in the HV-Nwell layer (drift region) formed on a main surface of a semiconductor substrate in a direction from the main surface to the inside. The lateral power MISFET has an arrangement on a plane of the main surface including a source layer (source region) and a drain layer (drain region) arranged at opposite sides to each other across a gate electrode (first conducting layer), and a dummy gate electrode (second conducting layer) that is different from the gate electrode is arranged between the gate electrode and the drain layer. |
| US08319287B2 |
Tunable gate electrode work function material for transistor applications
Described herein are metal gate electrode stacks including a low resistance metal cap in contact with a metal carbonitride diffusion barrier layer, wherein the metal carbonitride diffusion barrier layer is tuned to a particular work function to also serve as a work function metal for a pMOS transistor. In an embodiment, the work function-tuned metal carbonitride diffusion barrier prohibits a low resistance metal cap layer of the gate electrode stack from migrating into the MOS junction. In a further embodiment of the present invention, the work function of the metal carbonitride barrier film is modulated to be p-type with a pre-selected work function by altering a nitrogen concentration in the film. |
| US08319286B2 |
System and method for input pin ESD protection with floating and/or biased polysilicon regions
A system and method for electrostatic discharge protection. The system includes a first transistor including a first drain, a second transistor including a second drain, and a resistor including a first terminal and a second terminal. The first terminal is coupled to the first drain and the second drain. Additionally, the system includes a third transistor coupled to the second terminal and a protected system. The third transistor includes a first gate, a first dielectric layer located between the first gate and a first substrate, a first source, and a third drain. The protected system includes a fourth transistor, and the fourth transistor includes a second gate, a second dielectric layer located between the second gate and a second substrate, a second source, and a fourth drain. |
| US08319280B2 |
Recessed access device for a memory
Semiconductor memory devices having recessed access devices are disclosed. In some embodiments, a method of forming the recessed access device includes forming a device recess in a substrate material that extends to a first depth in the substrate that includes a gate oxide layer in the recess. The device recess may be extended to a second depth that is greater that the first depth to form an extended portion of the device recess. A field oxide layer may be provided within an interior of the device recess that extends inwardly into the interior of the device recess and into the substrate. Active regions may be formed in the substrate that abut the field oxide layer, and a gate material may be deposited into the device recess. |
| US08319267B2 |
Device including nonvolatile memory element
A device including a novel nonvolatile memory element is provided. A device including a nonvolatile memory element in which an oxide semiconductor is used as a semiconductor material for a channel formation region. The nonvolatile memory element includes a control gate, a charge accumulation layer which overlaps with the control gate with a first insulating film provided therebetween, and an oxide semiconductor layer formed using an oxide semiconductor material, which overlaps with the charge accumulation layer with a second insulating film provided therebetween. |
| US08319266B1 |
Etch stop layer for memory cell reliability improvement
A memory device and a method of making the memory device are provided. A first dielectric layer is formed on a substrate, a floating gate is formed on the first dielectric layer, a second dielectric layer is formed on the floating gate, a control gate is formed on the second dielectric layer, and at least one film, including a conformal film, is formed over a surface of the memory device. |
| US08319258B2 |
Electro-static discharge (ESD) clamping device
An ESD clamping device comprises a plurality of fingers each comprising a source region of first conductivity type formed in a substrate of second conductivity type, a drain region of said first conductivity type formed in the substrate, and a gate formed over the substrate and between the source and drain regions. At least one of the fingers each has an ESD implantation region formed in the substrate and partially underlying the drain region of the finger, the ESD implantation region being a heavily doped region of said second conductivity type. Furthermore, at least one of the fingers has a gate extension portion projecting from the gate and demarcating an additional region in at least the drain region of the finger, the additional region of said second conductivity type being electrically connected to at least one of the gate and the substrate of each of the fingers. |
| US08319254B2 |
Micro-electromechanical system devices
A micro-electromechanical system (MEMS) device includes a substrate, a first beam, a second beam, and a third beam. The first beam includes first and second portions separated by an isolation joint. The first and second portions each comprise a semiconductor and a first dielectric layer. An electrically conductive trace is mechanically coupled to the first beam and electrically coupled to the second portion's semiconductor but not the first portion's semiconductor. The second beam includes a second dielectric layer. The profile of each of the first second, and third beams has been formed by a dry etch. A cavity separates a surface of the substrate from the first, second, and third beams. The cavity has been formed by a dry etch. A side wall of each of the first, second, and third beams has substantially no dielectric layer disposed thereon, and the dielectric layer has been removed by a vapor-phase etch. |
| US08319250B2 |
Radiation-emitting semiconductor chip
A radiation-emitting semiconductor chip (1) is provided, which comprises a carrier (5), a semiconductor body (2) with a semiconductor layer sequence, a first contact (35) and a second contact (36). The semiconductor layer sequence comprises an active region (20) provided for generating radiation, which is arranged between a first semiconductor layer (21) and a second semiconductor layer (22). The carrier (5) comprises a major surface (51) facing the semiconductor body (2). The first semiconductor layer (21) is arranged on the side of the active region (20) facing the major surface (51) of the carrier (5) and is electrically contactable by means of the first contact (35). The second semiconductor layer (22) is electrically contactable by means of the second contact (36). A protection diode (4) is formed in a current path extending between the first contact (35) and the second contact (36) through the carrier (5). |
| US08319248B2 |
Slim LED package
Disclosed herein is a slim LED package. The slim LED package includes first and second lead frames separated from each other, a chip mounting recess formed on one upper surface region of the first lead frame by reducing a thickness of the one upper surface region below other upper surface regions of the first lead frame, an LED chip mounted on a bottom surface of the chip mounting recess and connected with the second lead frame via a bonding wire, and a transparent encapsulation material protecting the LED chip while supporting the first and second lead frames. |
| US08319245B2 |
Lead frame, and light emitting diode module having the same
A light emitting diode (LED) module includes a lead frame having a number (N) of conducting arms spaced apart from each other, where N≧3, and at least one LED die mounted on one of any two neighbor conducting arms. Any two neighbor conducting arms are electrically coupled each other. |
| US08319238B2 |
Light emitting device with improved light extraction efficiency
A light emitting device having a high degree of light extraction efficiency includes a substrate, and a light emitting structure disposed on one surface of the substrate, the substrate having an internal reformed region where the index of refraction differs from the remainder the substrate. The ratio of the depth of the reformed region (distance between the other surface of the substrate and the reformed region) to the thickness of the substrate is in a range of between 1/8 and 9/11. |
| US08319236B2 |
Low creep metallization for optoelectronic applications
A metallization on a semiconductor substrate is disclosed in the form of a laminate comprising a plurality of layers of a “conducting” metallization for providing electrical conductivity, interspersed with a plurality of layers of another metallization. By providing many layers the thickness of each individual layer can be reduced. Reduction in thickness of each layer leads to a reduction in grain size and a consequent reduction in creep over the lifetime of a device. |
| US08319235B2 |
Nitride semiconductor light-emitting device and method of manufacturing nitride semiconductor light-emitting device
A nitride semiconductor light-emitting device including a coating film and a reflectance control film successively formed on a light-emitting portion, in which the light-emitting portion is formed of a nitride semiconductor, the coating film is formed of an aluminum oxynitride film or an aluminum nitride film, and the reflectance control film is formed of an oxide film, as well as a method of manufacturing the nitride semiconductor light-emitting device are provided. |
| US08319231B2 |
Display device
A display device includes a first organic electroluminescent element and a second organic electroluminescent element. The first and second organic electroluminescent elements have different luminescent colors. The first and second organic electroluminescent elements each include, in series, a first electrode, a first charge transport layer, a second charge transport layer, a light-emitting layer, and a second electrode. The first charge transport layer is common to the first and second organic electroluminescent elements. The second charge transport layer of the first organic electroluminescent element is different in thickness from the second charge transport layer of the second organic electroluminescent element. The concentration of a dopant material contained in the first charge transport layer is less than that of the second charge transport layer. |
| US08319230B1 |
Stackable optoelectronics chip-to-chip interconnects and method of manufacturing
An optoelectronics chip-to-chip interconnects system is provided, including at least one packaged chip to be connected on the printed-circuit-board with at least one other packaged chip, optical-electrical (O-E) conversion mean, waveguide-board, and (PCB). Single to multiple chips interconnects can be interconnected provided using the technique disclosed in this invention. The packaged chip includes semiconductor die and its package based on the ball-grid array or chip-scale-package. The O-E board includes the optoelectronics components and multiple electrical contacts on both sides of the O-E substrate. The waveguide board includes the electrical conductor transferring the signal from O-E board to PCB and the flex optical waveguide easily stackable onto the PCB to guide optical signal from one chip-to-other chip. Alternatively, the electrode can be directly connected to the PCB instead of including in the waveguide board. The chip-to-chip interconnections system is pin-free and compatible with the PCB. The main advantages of this invention are to use the packaged chip for interconnection and the conventional PCB technology can be used for low speed electrical signal connection. Also, the part of the heat from the packaged chip can be transmitted to the PCB through the conductors, so that complex cooling system can be avoided. |
| US08319219B2 |
Light-emitting device
According to present invention, system on panel without complicating the process of TFT can be realized, and a light-emitting device that can be formed by lower cost than that of the conventional light-emitting device can be provided. A light-emitting device is provided in which a pixel portion is provided with a pixel including a light-emitting element and a TFT for controlling supply of current to the light-emitting element; a TFT included in a drive circuit and a TFT for controlling supply of current to the light-emitting element include a gate electrode, a gate insulating film formed over the gate electrode, a first semiconductor film, which overlaps with the gate electrode via the gate insulating film, a pair of second semiconductor films formed over the first semiconductor film; the pair of second semiconductor films are doped with an impurity to have one conductivity type; and the first semiconductor film is formed by semiamorphous semiconductor. |
| US08319217B2 |
Oxide semiconductor thin film transistor, method of manufacturing the same, and organic electroluminescent device including the same
A thin film transistor including: a substrate; a gate electrode formed on the substrate; a gate insulating layer formed on the gate electrode and exposed portions of the substrate; an oxide semiconductor layer formed on the gate insulating layer to correspond to the gate electrode, and comprising an HfInZnO-based oxide semiconductor, wherein the oxide semiconductor layer has a Zn concentration gradient; and source and drain regions respectively formed on both sides of the oxide semiconductor layer and the gate insulating layer. |
| US08319214B2 |
Thin film field effect transistor with amorphous oxide active layer and display using the same
A TFT is provided which includes on a substrate, at least a gate electrode, a gate insulating layer, an active layer containing an amorphous oxide semiconductor, a source electrode, and a drain electrode, wherein a mean square interface roughness between the gate insulating layer and the active layer is less than 2 nm, a carrier concentration of the active layer is 1×1015 cm−3 or more, and a film thickness of the active layer is 0.5 nm or more and less than 20 nm. A TFT is provided which has high field effect mobility and a high ON-OFF ratio, and is improved in environmental temperature dependency. Also, a display using the TFT is provided. |
| US08319212B2 |
Light-emitting device and electronic device
The present invention provides a light-emitting element and a light-emitting device which have high contrast, and specifically, provides a light-emitting device whose contrast is enhanced, not by using a polarizing plate but using a conventional electrode material. Reflection of external light is suppressed by provision of a light-absorbing layer included between a non-light-transmitting electrode and a light-emitting layer. As the light-absorbing layer, a layer is used, which is obtained by adding a halogen atom into a layer including an organic compound and a metal oxide. Further, the light-absorbing layer is formed also over a region in which a thin film transistor for driving a light-emitting element is formed, a region in which a wiring is formed, and the like, and thus light is extracted from the side opposite to the region in which the TFT is formed, thereby reducing reflection of external light. |
| US08319209B2 |
Organic electroluminescent device and electronic apparatus that can effectively release gas that is generated
An organic electroluminescent device includes a substrate; a plurality of light-emitting elements disposed on the substrate and including first transparent electrodes, a second transparent electrode, and light-emitting layers held therebetween; reflective layers disposed opposite the light-emitting layers with the first electrodes therebetween; a first insulating film disposed between the substrate and the reflective layers and formed of an organic material; and a second insulating film disposed between the first electrodes and the reflective layers so as to cover the reflective layers and the first insulating film. The second insulating film has a first through-hole at a position not overlapping the first electrodes in plan view. The first through-hole extends through the second insulating film to reach the first insulating film. |
| US08319208B2 |
Methods of forming thin films for molecular based devices
The invention generally encompasses methods of forming thin films molecular based devices, and devices formed therefrom. Some embodiments relate to molecular memory cells, molecular memory arrays, electronic devices including molecular memory, and processing systems and methods for producing molecular memories. More particularly, the present invention encompasses methods and molecular based devices comprising a wetting layer and redox-active molecules. |
| US08319205B2 |
Nonvolatile nanotube programmable logic devices and a nonvolatile nanotube field programmable gate array using same
Field programmable device (FPD) chips with large logic capacity and field programmability that are in-circuit programmable are described. FPDs use small versatile nonvolatile nanotube switches that enable efficient architectures for dense low power and high performance chip implementations and are compatible with low cost CMOS technologies and simple to integrate. |
| US08319202B2 |
Color registration strategy for preprinted forms
A computer-implemented method for performing color registration on template media having template markings thereon. The method comprising sensing the template media using a linear array sensor to obtain first image data; printing a test pattern on the template media; sensing the template media along with the test pattern printed thereon to obtain second image data; transforming the first image data and the second image data into an absorbance space to obtain a first absorbance and a second absorbance, respectively; calculating a difference between the first and the second absorbances to obtain an output absorbance; transforming the output absorbance into a reflectivity space to obtain an output data; determining a process direction misregistration and a cross-process direction misregistration from the output data; and adjusting a cross-process position and a process position of print heads based on the process and cross-process direction misregistration to provide accurate color registration on subsequent template media. |
| US08319195B2 |
Methods and apparatus for sterilization of air and objects
A portable air sterilization apparatus includes a portable chamber forming an interior volume, a portable source for producing a single beam of collimated light energy, and a rotating beam redirector. The portable chamber includes a first end for introducing air into the chamber, a second end for permitting air to exit from the chamber, a transparent orifice through which a single beam of collimated light energy can be introduced into the interior volume of the chamber; and at least one reflective wall. The rotating beam redirector is adapted to rotate through a complete revolution about a rotational axis and to redirect the single beam of collimated light energy within the chamber during said revolution. |
| US08319186B2 |
Silicon photomultiplier trigger network
An apparatus (208) includes a plurality of photosensors (310). Photon trigger signals produced in response to signals from the sensors are received by a trigger line network that includes segment (302), intermediate (304), and master (306) lines. The trigger network is configured to reduce a temporal skew introduced by the trigger line network. Validation logic (324) provides a trigger validation output signal (610). |
| US08319183B2 |
Methods of characterizing and measuring particulate filter accumulation
Methods of characterizing and measuring particulate accumulation in a family of particulate filters (10) are disclosed. The disclosure can be applied to diesel, gasoline and natural gas fueled engines, fluid streams bearing dust, and chemical and biological substances such as may be found in laboratory fluids, for example, air. In one embodiment, the disclosure is directed to measuring diesel particulate accumulation in a family of diesel particulate filters. The methods include measuring calibration complex terahertz transmission spectra (PC(f)) of at least a portion (17) of at least one particulate or diesel particulate filter in the family for different known particulate or diesel particulate amounts (ADP). The method also involves performing a partial least squares (PLS) analysis on the calibration complex terahertz transmission spectra to establish a calibration relationship between the complex terahertz transmission spectra and the particulate or diesel particulate amounts. The complex transmission spectrum of a subject particulate filter or diesel particulate filter having an unknown amount of particulate or diesel particulate accumulation is then determined and compared to the linear calibration relationship to establish a measured amount of particulates or diesel particulates. The methods include using a terahertz (THz) system (100) to obtain the complex terahertz transmission spectra for the calibration and subject particulate or diesel particulate filters. |
| US08319181B2 |
System and method for localization of large numbers of fluorescent markers in biological samples
A method and system for the imaging and localization of fluorescent markers such as fluorescent proteins or quantum dots within biological samples is disclosed. The use of recombinant genetics technology to insert “reporter” genes into many species is well established. In particular, green fluorescent proteins (GFPs) and their genetically-modified variants ranging from blue to yellow, are easily spliced into many genomes at the sites of genes of interest (GoIs), where the GFPs are expressed with no apparent effect on the functioning of the proteins of interest (PoIs) coded for by the GoIs. One goal of biologists is more precise localization of PoIs within cells. The invention is a method and system for enabling more rapid and precise PoI localization using charged particle beam-induced damage to GFPs. Multiple embodiments of systems for implementing the method are presented, along with an image processing method relatively immune to high statistical noise levels. |
| US08319180B2 |
Kingdon mass spectrometer with cylindrical electrodes
The invention relates to measuring devices of an electrostatic Fourier transform mass spectrometer and measurement methods for the acquisition of mass spectra with high mass resolution. The measuring device includes electrostatic measuring cells according to the Kingdon principle, in which ions can, when appropriate voltages are applied, orbit on circular trajectories around the cylinder axis between two concentric cylindrical surfaces, which are composed of specially shaped sheath electrodes, insulated from each other by parabolic gaps, and can harmonically oscillate in the axial direction, independently of their orbiting motion. In the longitudinal direction, the two cylindrical surfaces of the measuring cell are divided by the parabolic separating gaps into different types of double-angled and tetragonal sheath electrode segments. Appropriate voltages at the sheath electrode segments generate a potential distribution between the two concentric cylindrical surfaces which forms a parabolic potential well in the axial direction for orbiting ions. The ion clouds oscillating harmonically in the axial direction in this potential well induce image currents in suitable electrodes, from which the oscillation frequencies can be determined by Fourier analyses. |
| US08319179B2 |
Sample pretreatment apparatus and mass spectrometer provided with the same
The present invention relates to a pretreatment apparatus that performs concentration and separation of a sample, and in particular, in order to provide a sample pretreatment apparatus using a solid-phase extraction column, and a mass spectrometer using the same, which is particularly suitable for clinical analysis in which qualitative/quantitative analysis of a biological sample such as blood is performed, according to each operational step for a solid-phase extraction treatment, for example, a collection device serving as flow passages or containers for collection of waste liquid or extracted matter is installed on a bottom face of the solid-phase extraction column, and the extracted matter is separately collected without being mixed with waste liquid by switching the positions of the collection device. |
| US08319169B2 |
Optical filter and optical module provided with same
An optical filter comprising: a first substrate; a second substrate facing the first substrate, the second substrate including a first surface and a second surface, a first height of the first surface being different from a second height of the second surface; a first mirror formed on the first surface of the second substrate; a second mirror formed on the second surface of the second substrate; a third mirror formed on the first substrate, the third mirror facing the first mirror; a fourth mirror formed on the first substrate, the fourth mirror facing the second mirror; a first electrode formed on the first substrate; and a second electrode formed on the second substrate, the second electrode facing the first electrode. |
| US08319167B2 |
Solid state imaging device and electronic apparatus
A solid state imaging device includes: a sensor unit that has a semiconductor substrate in which pixels including photoelectric conversion parts are disposed in an array on a light receiving surface; a lens module which has a plurality of optical members including a lens and which is disposed such that light including information on an image to be imaged is incident on the light receiving surface of the sensor unit; and a phase shift mask in which regions for dividing all light beams into a plurality of groups are set and which makes a different phase shift occur in each of the regions for the light. |
| US08319165B2 |
Variable rate chemical management for agricultural landscapes
An apparatus for applying agrochemicals within a geographical area includes a dispensing system configured for dispensing the agrochemicals and a variable rate controller operatively connected to the dispensing system and configured to control dispensement of agrochemicals from the dispensing system. The variable rate controller is programmed with an algorithm which uses a plant growth stage appropriate plug value for an initial calibration. A method for applying agrochemicals within a geographical area includes acquiring a growth stage appropriate plug value for an initial calibration, using the growth state appropriate plug value in the initial calibration, and applying agrochemicals to the geographical area according to the initial calibration. |
| US08319162B2 |
Steerable spin-stabilized projectile and method
A spin-stabilized projectile has its course controlled by counter rotation of an internal mass about a longitudinal axis of the projectile. The internal mass may be a boom within a cavity of an external body of the projectile. The internal mass may be tiltable relative to the hull, and may be configured to counter rotate relative to the hull about the axis of the hull. The counter-rotation may keep the boom in a substantially same orientation relative to the (non-spinning) environment outside of the projectile. The positioning of the boom or other weight within the projectile thus may be used to steer the projectile, by providing an angle of attack to the projectile hull. A magnetic system may be used to counter rotate the boom or other weight. The projectile may have a laser guidance system to aid in steering the projectile toward a desired aim point. |
| US08319158B2 |
Electric heating radiator device
The present invention relates to a method of manufacturing an electric heating device, comprising a housing in which a heating block is held with the pretensioning force of at least one spring element located approximately at the same level as the heating block in its post assembly position and which defines opposite housing apertures between which the heating block is exposed, wherein the heating block is introduced into a housing part and the heating block is enclosed in the housing by another housing part. The spring element is brought into its assembled position and pretensioned when the housing is being closed to enclose the heating block. |
| US08319152B2 |
Shaver with hair preheating
A hair cutting head, for use in a hair cutting apparatus having an elongated heated wire suitable for heating hair growing from a skin surface, and at least one blade placed at one side of the elongated heated wire, the blade being configured to cut the hair which has been heated by the heated wire. The wire is heated to a temperature of at least 50° C. |
| US08319149B2 |
Radiant anneal throughput optimization and thermal history minimization by interlacing
The time between illumination of adjacent zones of a workpiece edge is extended by a long cool-down period or delay, by interlacing a radiation beam scanning pattern. During the cool-down period, the beam successively scans (along the fast axis) two rows separated by about half the wafer diameter, and travels back and then forth (along the slow axis) across the distance between the two rows, while the radiation beam source continuously generates the beam. |
| US08319147B2 |
Laser machining method and laser machining apparatus
There is provided a laser machining method and a laser machining apparatus whose machining accuracy and quality excel without lowering machining efficiency. One hole is machined by a split beam that is a first pulsed laser beam and another split beam that is a second pulsed laser beam whose irradiation position is determined based on irradiation position of the first laser beam. In this case, the machining quality may be improved by machining the circular hole by equalizing circling directions and angular velocity of the split beams. A beam splitter splits a laser beam outputted out of one laser oscillator into the split beams and AOMs can time-share them. |
| US08319146B2 |
Method and apparatus for laser cutting a trench
A system for producing at least one trench to improve film cooling in a sample is provided. The system includes at least one laser source outputting at least one pulsed laser beam. The pulsed laser beam includes a pulse duration including a range less than about 50 μs, an energy per pulse having a range less than about 0.1 Joule, and a repetition rate with a range greater than about 1000 Hz. The system also includes a control subsystem coupled to the laser source, the control subsystem configured to synchronize a position of the sample with the pulse duration and energy level in order to selectively remove at least one of a thermal barrier coating, a bondcoat and a substrate metal in the sample to form the at least one trench. |
| US08319145B2 |
System and method for gemstone micro-inscription
A gemstone micro-inscription system, comprising an energy source, a spatial light modulator, and a control, the control controlling a spatial light pattern modulation of the spatial light modulator, wherein the spatial light modulator exposes a photoresist on the gemstone, which selectively impedes an etching process to produce a pattern on the gemstone corresponding to the spatial light modulation pattern. |
| US08319144B2 |
Apparatus and method for constructing three-dimensional laminated shapes for field pole structures
A method for constructing a three-dimensional laminated shape includes selecting a first lamination strip from a plurality of lamination strips with different widths assembled on a spool. The first lamination strip is stacked on a stacking device and is cut at a first lamination length. A second lamination strip is selected from the spool. The second lamination strip is stacked and cut at a second lamination length different than the first lamination length. The process is repeated to construct a three-dimensional laminated shape of an electrodynamic device. In another embodiment, a computer readable storage medium includes executable instructions to collect design information characterizing a three-dimensional laminated shape and compute lamination parameters based on the design information. The computer readable storage medium further includes executable instructions to direct a plurality of components to construct a three-dimensional laminated shape of an electrodynamic device based on the lamination parameters. The three-dimensional laminated shape comprises a plurality of lamination strips of different lamination widths and different lamination lengths. |
| US08319141B2 |
Cooling block forming electrode
The present invention is a cooling block that forms an electrode for generating a plasma for use in a plasma process, and includes a channel for a cooling liquid, the cooling block comprising: a first base material and a second base material respectively made of aluminum, at least one of the first and second base materials having a recess for forming a channel for a cooling liquid; and a diffusion bonding layer, in which zinc is diffused in aluminum, and an anti-corrosion layer of a zinc oxide film, the layers being formed by interposing zinc between the first and second base materials, and by bonding the first and second base materials with zinc interposed therebetween in a heating atmosphere containing oxygen. |
| US08319136B2 |
Arcing fault and arc flash protection system having a high-speed switch
A high-speed arc terminator for an electrical power distribution system includes a sealed, evacuated housing, and a controllable mechanical switch having first and second electrically conductive contacts enclosed within the housing and adapted to be coupled to the power distribution system outside the housing. A trigger conductor extends into the housing and has an exposed end near the gap between the contacts when the contacts are in the open position. At least one of the contacts is movable between an open position in which the contacts are separated by a gap, and a closed position in which the contacts engage each other, and an operating mechanism is provided for moving the at least one contact between the open and closed positions. A high voltage source is controllably coupled to the trigger conductor for supplying a high-voltage pulse to the trigger conductor in response to the detection of an arcing fault. The high-voltage pulse produces an arc within the gap between the contacts, to shunt fault current from the power distribution system across the gap, from one of the contacts to the other, before the contacts engage each other. |
| US08319131B2 |
Device for switching an electrical switch on and off
A device is disclosed for switching an electrical switch on and off, with a drive shaft and an output shaft. The drive shaft and the output shaft run transversely with respect to one another and interact in such that a rotation of the drive shaft entails a rotation of the output shaft, the drive shaft being rotatable between an ON position and an OFF position, and the output shaft being rotatable between a switch-on position and a switch-off position. The output shaft is connected to the switch which can be switched to the switch-on and the switch-off position as a result of the rotation of the output shaft. The drive shaft and the output shaft are connected to one another via a displaceable sliding element which, during the rotation of the drive shaft, is displaced, and the output shaft is rotated by the sliding element in the course of displacement. |
| US08319130B2 |
Light emitting key structure
A light emitting key structure is provided. The key structure includes a base, a reflective sheet, a circuit board, an elastic member, a linkage mechanism, and a key cap sequentially disposed one on another in order. The reflective sheet is disposed on the base. The circuit board is made of a light guide material. At least one light source is bonded to a lateral side of the circuit board. The circuit board, together with the light source bonded to the lateral side thereof is disposed on the reflective sheet. The elastic member is directly coupled to the circuit board. The key cap is featured with a light transmission characteristic. Therefore, in operation, the light emitted from the light source can be directly guided into the circuit board, and then outputted from the light transmissive key cap, thus achieving the light emitting effect. |
| US08319129B2 |
Keyboard having backlight function
A keyboard having a backlight function, the keyboard includes a key top having a light permeating region, the key top being where one end of a link member is provided; a membrane sheet having a contact, the contact being conductive when the key top is pushed; a support panel made of metal, the support panel being where another end of the link member is provided; and a light guide plate where a light is guided from a light source. The key top, the membrane sheet, the support panel, and the light guide plate are stacked from a top side; the light guide plate is formed of a member having an elasticity higher than an elasticity of the support panel; and a part of an external edge part of the light guide plate, seen from the top side, projects outside the support panel. |
| US08319127B2 |
Electronic apparatus
An electronic apparatus includes an operation member which includes an operation portion, a substrate which includes a switch detecting pattern and a ground pattern, and a sheet member which is disposed between the operation member and the substrate and provided with a metal piece for causing the switch detecting pattern to be electrically continuous to the ground pattern according to an operation to the operation portion, wherein the metal piece is in contact with the ground pattern, and the sheet member covers the metal piece with an insulating member in such a manner that at least a part of a surface of the metal piece is exposed. |
| US08319126B2 |
Liquid switches and switching devices and systems and methods thereof
A dispensing apparatus includes a housing defining a channel, a plunger slidably engaged with an inner surface of the channel, a substrate with one or more passages each having two or more openings, a liquid in each of the one or more passages, at least one fluid, and a force application system. The substrate is disposed in the channel on one side of the plunger. The liquid in each of the one or more passages has a volume which exceeds an internal volume of each the one or more passages and forms a liquid drop around each of the openings. The liquid drops are fluidly connected to one another and each of the liquid drops is individually adjustable between two or more sizes. Each of the sizes and a location of each of the liquid drops define one of two or more switch positions. The fluid is located in the channel on the one side of the plunger and substantially surrounding the liquid drops. The force application system is configured to individually and selectively apply a force on the liquid in each of the one or more passages to control switching between the two or more switch positions of each of the liquid drops. Engaging one or more of the switch positions moves the plunger along the inner surface of the channel away from the substrate. |
| US08319125B2 |
Pedal input device with three rotational degrees of freedom
A pedal input device includes a base plate; a rotation center portion provided at the center of the base plate; a contacting plate having a yaw switch contacting portion protruding downwards from lower surface of the contacting plate; a pedal plate carried by the contacting plate and foot-operated so as to cause a drive member to make three-degree-of-freedom movement; a pair of pitch switches installed on the base plate in an opposing relationship with each other; a pair of roll switches installed on the base plate in an perpendicular relationship to the pitch switches so that the roll switches can be alternately contacted to the contacting plate of the pedal plate; and a pair of yaw switches installed on the base plate in an spaced-apart relationship with each other so that the yaw switches can be alternately contacted to the yaw switch contacting portion as the pedal plate rotates. |
| US08319121B2 |
Server enclosure
A server enclosure includes a bottom wall, two sidewalls extending from opposite sides of the bottom wall, a backboard to electrically connected to a number of hard disk drives, and two fixing elements. The fixing elements are fixed on opposite ends of the backboard. Each fixing element includes a connection board fixed on the backboard, a first fixing portion extending from a bottom of the connection board along a first direction, and a positioning arm extending from a side of the connection board along the first direction. The first fixing portion is fixed on the bottom wall. The positioning arm is slidably positioned on the corresponding sidewall to fix the backboard. |
| US08319120B2 |
Compact spillover fitting and method of use thereof
A spillover fitting is positioned on an upstanding side of a lateral cable trough. The spillover fitting includes a first exit path having a first curved surface that extends at least partially over a base of the lateral cable trough, and a bottom wall having a second curved surface intersecting with the first curved surface. The first surface curves upward relative to the base of the lateral cable trough and defines a top surface of a cable path, and the second surface is convexly curved and defines a bottom surface of the cable path. The radius of curvature of the first curved surface is equal to the radius of curvature of the second curved surface. |
| US08319119B2 |
Section for a window, door or facade element comprising an electric cable
The present disclosure relates to a frame section for a window or casement frame of a window, door or facade. The frame section includes an undercut cable groove, which is situated on the outer periphery of the frame section and is designed to hold an electric cable including two or more electric conductors in a positive fit. The frame section has a centering frame for the cable, which can be placed over the cable. |
| US08319117B2 |
Printed circuit board
A printed circuit board includes signal layers, ground layers, and a power layer, which are superposed. A closed trace is set along edges of each of the signal layers and the power layers. A number of vias are defined in each trace at intervals. Each via extends through the signal layers, the ground layers, and the power layer. Each via is electrically connected to the traces of the signal layers and the power layer, and electrically connected to the ground layers. |
| US08319110B2 |
Dual-layer flexible printed circuit
A dual-layer flexible printed circuit is disclosed. The dual-layer flexible printed circuit includes an inner flexible printed circuit and an outer flexible printed circuit which overlaps the inner flexible printed circuit. The inner flexible printed circuit can be bent and forms a protrusion offset from the outer flexible printed circuit. The dual-layer flexible printed circuit further includes a fixing element to secure the protrusion to prevent the protrusion from extruding along a longitudinal direction of the dual-layer flexible printed circuit. |
| US08319109B2 |
Electro-optical device and electronic apparatus
An electro-optical device includes an electro-optical panel, a first wiring board and a second wiring board. The first wiring board having a one-side first connection terminal electrically connected to the panel-side connection terminal at one end of a first wiring forming surface and having an other-side first connection terminal at the other end of the first wiring forming surface. The second wiring board having one-side second connection terminal electrically connected to the other-side first connection terminal at one end of a second wiring forming surface and having the other-side second connection terminal at the other end of the second wiring forming surface. |
| US08319101B2 |
Polymer bushing and cable termination using the same
A polymer bushing includes a conductor bar, a conductor insertion hole at a lower end, a rigid insulator around the outer circumference of the conductor bar and having a receiving port for a cable termination, a polymer covering around the outer circumference of the insulator and a number of shades 4a formed separately along the longer dimension at the outer circumference. A large diameter part is provided above the conductor insertion hole which is in the vicinity of the lower end part of the insulator. A cylindrical shielding metal fitting is concentrically embedded together with the conductor bar in the large diameter part. An electric-field stress-control layer is provided at the interface between the large diameter part and the polymer covering. |
| US08319098B2 |
Porous semiconductor film on a substrate
The invention relates to a method of producing a porous semiconductor film and the film resulting from such production. It furthermore relates to an electronic device incorporating such film and to potential uses of such film. |
| US08319097B2 |
Substrate and collector grid structures for integrated series connected photovoltaic arrays and process of manufacture of such arrays
The invention teaches novel structure and methods for producing electrical current collectors and electrical interconnection structure. Such articles find particular use in facile production of modular arrays of photovoltaic cells. The current collector and interconnecting structures may be initially produced separately from the photovoltaic cells thereby allowing the use of unique materials and manufacture. Subsequent combination of the structures with photovoltaic cells allows facile and efficient completion of modular arrays. Methods for combining the collector and interconnection structures with cells and final interconnecting into modular arrays are taught. |
| US08319095B2 |
Method of making an antireflective silica coating, resulting product, and photovoltaic device comprising same
A low-index silica coating may be made by forming silica sol comprising a silane and/or a colloidal silica. The silica precursor may be deposited on a substrate (e.g., glass substrate) to form a coating layer. The coating layer may then be cured and/or fired using temperature(s) of from about 550 to 700° C. A capping layer composition comprising an antifog composition including a siloxane and/or hydrofluororether may be formed, deposited on the coating layer, then cured and/or fired to form a capping layer The capping layer improves the durability of the coating. The low-index silica based coating may be used as an antireflective (AR) film on a front glass substrate of a photovoltaic device (e.g., solar cell) or any other suitable application in certain example instances. |
| US08319090B2 |
Organic photoelectric conversion material and organic thin-film photoelectric conversion device
An organic photoelectric conversion material for use in an organic thin-film photoelectric conversion device, containing a compound represented by formula 1; and an organic thin-film photoelectric conversion device having a photoelectric conversion layer which containing the organic photoelectric conversion material: wherein D represents an electron-donating aromatic substituent whose bonding site atom is a sp2 carbon atom; and a plurality of D may be the same or different from each other. |
| US08319087B2 |
System and method for dynamic, feature-based playlist generation
Methods and systems for generating playlists of media items with audio data are disclosed. Based on two received feature sets, media items corresponding to each feature set are identified. Transition characteristics are also received. Based on the identified media items and transition characteristics, a dynamic playlist is generated that transitions from media items having characteristics of the first feature set to media items having characteristics of the second feature set. Each time the playlist is generated, it may include a different set of media items. |
| US08319083B2 |
Electronic system, methods and apparatus for teaching and examining music
Electronic systems, methods and apparatus for teaching and examining music are presented. The method includes presenting a user with one or more musical tasks and providing a menu with one or more selectable icons. Selection of one of the icons activates functionality to enable the user to form an element of musical notation. The method includes comparing one or more characteristics of the element of musical notation with one or more predetermined thresholds in response to a user request and generating a mark, score or grade based on the result of the comparison. |
| US08319082B1 |
Stringed instrument keyboard
A stringed instrument keyboard consists of a plate secured above a fingerboard of an instrument with multiple keys uniquely arranged on that plate. Each key consists of a rectangular key top, a key shaft extending downward from the key top through an access hole in the plate toward the fingerboard, and a key tip attached to the opposite end of the key shaft suitable for depressing an instrument string against a particular fret on the fingerboard. Pressing the key top causes the associated key tip to apply pressure to the string beneath that key in an opportune position to hold the string against an adjacent fret. Thumb levers may be used to depress certain keys. The keyboard facilitates learning how to play a stringed instrument, by simplifying the manipulation required to hold strings in appropriate positions and minimizing the pain associated with holding strings with finger tips. |
| US08319081B1 |
Combination banjo, bass, and guitar
This invention is a combination stringed musical instrument like a banjo, bass, and guitar. The invention can be either acoustic or electric. A combination banjo, bass, and guitar and method of playing is provided in which the sixth string is set as a bass string, the fifth string is setup as a banjo fifth string, and the remaining four strings are configured as guitar strings which can be plucked substantially simultaneously by a player, resulting in the simultaneous playing of banjo, bass, and guitar by a single player. Various combinations of string diameters for each part of the combination are disclosed along with options for using a capo or “tunneling” the fifth string at the fifth fret. |
| US08319079B2 |
Plants and seeds of hybrid corn variety CH039233
According to the invention, there is provided seed and plants of the hybrid corn variety designated CH039233. The invention thus relates to the plants, seeds and tissue cultures of the variety CH039233, and to methods for producing a corn plant produced by crossing a corn plant of variety CH039233 with itself or with another corn plant, such as a plant of another variety. The invention further relates to genetic complements of plants of variety CH039233. |
| US08319077B1 |
Inbred maize variety PH13C5
A novel maize variety designated PH13C5 and seed, plants and plant parts thereof. Methods for producing a maize plant that comprise crossing maize variety PH13C5 with another maize plant. Methods for producing a maize plant containing in its genetic material one or more traits introgressed into PH13C5 through backcross conversion and/or transformation, and to the maize seed, plant and plant part produced thereby. Hybrid maize seed, plant or plant part produced by crossing the variety PH13C5 or a locus conversion of PH13C5 with another maize variety. |
| US08319076B1 |
Inbred maize variety PH18T0
A novel maize variety designated PH18T0 and seed, plants and plant parts thereof. Methods for producing a maize plant that comprise crossing maize variety PH18T0 with another maize plant. Methods for producing a maize plant containing in its genetic material one or more traits introgressed into PH18T0 through backcross conversion and/or transformation, and to the maize seed, plant and plant part produced thereby. Hybrid maize seed, plant or plant part produced by crossing the variety PH18T0 or a locus conversion of PH18T0 with another maize variety. |
| US08319069B2 |
Plants and seeds of hybrid corn variety CH809540
According to the invention, there is provided seed and plants of the hybrid corn variety designated CH809540. The invention thus relates to the plants, seeds and tissue cultures of the variety CH809540, and to methods for producing a corn plant produced by crossing a corn plant of variety CH809540 with itself or with another corn plant, such as a plant of another variety. The invention further relates to genetic complements of plants of variety CH809540. |
| US08319067B2 |
Plants and seeds of hybrid corn variety CH793575
According to the invention, there is provided seed and plants of the hybrid corn variety designated CH793575. The invention thus relates to the plants, seeds and tissue cultures of the variety CH793575, and to methods for producing a corn plant produced by crossing a corn plant of variety CH793575 with itself or with another corn plant, such as a plant of another variety. The invention further relates to genetic complements of plants of variety CH793575. |
| US08319055B2 |
Plants and seeds of hybrid corn variety CH867615
According to the invention, there is provided seed and plants of the hybrid corn variety designated CH867615. The invention thus relates to the plants, seeds and tissue cultures of the variety CH867615, and to methods for producing a corn plant produced by crossing a corn plant of variety CH867615 with itself or with another corn plant, such as a plant of another variety. The invention further relates to genetic complements of plants of variety CH867615. |
| US08319053B2 |
Plants and seeds of hybrid corn variety CH035204
According to the invention, there is provided seed and plants of the hybrid corn variety designated CH035204. The invention thus relates to the plants, seeds and tissue cultures of the variety CH035204, and to methods for producing a corn plant produced by crossing a corn plant of variety CH035204 with itself or with another corn plant, such as a plant of another variety. The invention further relates to genetic complements of plants of variety CH035204. |
| US08319049B2 |
Plants and seeds of hybrid corn variety CH714201
According to the invention, there is provided seed and plants of the hybrid corn variety designated CH714201. The invention thus relates to the plants, seeds and tissue cultures of the variety CH714201, and to methods for producing a corn plant produced by crossing a corn plant of variety CH714201 with itself or with another corn plant, such as a plant of another variety. The invention further relates to genetic complements of plants of variety CH714201. |
| US08319046B1 |
Inbred corn line SLM07
An inbred corn line, designated SLM07, the plants and seeds of the inbred corn line SLM07, methods for producing a corn plant, either inbred or hybrid, produced by crossing the inbred corn line SLM07 with itself or with another corn plant, and hybrid corn seeds and plants produced by crossing the inbred line SLM07 with another corn line or plant and to methods for producing a corn plant containing in its genetic material one or more transgenes and to the transgenic corn plants produced by that method. This invention also relates to inbred corn lines derived from inbred corn line SLM07, to methods for producing other inbred corn lines derived from inbred corn line SLM07 and to the inbred corn lines derived by the use of those methods. |
| US08319044B2 |
Potato cultivar FF X RG 387
A potato cultivar designated FF X RG 387 is disclosed. The invention relates to the tubers of potato cultivar FF X RG 387, to the seeds of potato cultivar FF X RG 387, to the plants of potato FF X RG 387, to the plant parts of potato cultivar FF X RG 387 and to methods for producing a potato plant produced by crossing potato cultivar FF X RG 387 with itself or with another potato variety. The invention also relates to methods for producing a potato plant containing in its genetic material one or more transgenes and to the transgenic potato plants and plant parts produced by those methods. This invention also relates to potato cultivars or breeding cultivars and plant parts derived from potato variety FF X RG 387, to methods for producing other potato cultivars, lines or plant parts derived from potato cultivar FF X RG 387 and to the potato plants, varieties, and their parts derived from use of those methods. The invention further relates to hybrid potato tubers, seeds, plants and plant parts produced by crossing potato cultivar FF X RG 387 with another potato cultivar. |
| US08319040B2 |
Soybean variety A1024255
The invention relates to the soybean variety designated A1024255. Provided by the invention are the seeds, plants and derivatives of the soybean variety A1024255. Also provided by the invention are tissue cultures of the soybean variety A1024255 and the plants regenerated therefrom. Still further provided by the invention are methods for producing soybean plants by crossing the soybean variety A1024255 with itself or another soybean variety and plants produced by such methods. |
| US08319037B1 |
Soybean variety XBP27004
A novel soybean variety, designated XBP27004 is provided. Also provided are the seeds of soybean variety XBP27004, cells from soybean variety XBP27004, plants of soybean XBP27004, and plant parts of soybean variety XBP27004. Methods provided include producing a soybean plant by crossing soybean variety XBP27004 with another soybean plant, methods for introgressing a transgenic, mutant trait, and/or native trait into soybean variety XBP27004, methods for producing other soybean varieties or plant parts derived from soybean variety XBP27004. Soybean seed, cells, plants, germplasm, breeding lines, varieties, and plant parts produced by these methods and/or derived from soybean variety XBP27004 are further provided. |
| US08319036B1 |
Soybean variety XBP09004
A novel soybean variety, designated XBP09004 is provided. Also provided are the seeds of soybean variety XBP09004, cells from soybean variety XBP09004, plants of soybean XBP09004, and plant parts of soybean variety XBP09004. Methods provided include producing a soybean plant by crossing soybean variety XBP09004 with another soybean plant, methods for introgressing a transgenic, mutant trait, and/or native trait into soybean variety XBP09004, methods for producing other soybean varieties or plant parts derived from soybean variety XBP09004. Soybean seed, cells, plants, germplasm, breeding lines, varieties, and plant parts produced by these methods and/or derived from soybean variety XBP09004 are further provided. |
| US08319034B2 |
Soybean variety A1016511
The invention relates to the soybean variety designated A1016511. Provided by the invention are the seeds, plants and derivatives of the soybean variety A1016511. Also provided by the invention are tissue cultures of the soybean variety A1016511 and the plants regenerated therefrom. Still further provided by the invention are methods for producing soybean plants by crossing the soybean variety A1016511 with itself or another soybean variety and plants produced by such methods. |
| US08319033B2 |
Soybean variety A1016136
The invention relates to the soybean variety designated A1016136. Provided by the invention are the seeds, plants and derivatives of the soybean variety A1016136. Also provided by the invention are tissue cultures of the soybean variety A1016136 and the plants regenerated therefrom. Still further provided by the invention are methods for producing soybean plants by crossing the soybean variety A1016136 with itself or another soybean variety and plants produced by such methods. |
| US08319030B2 |
Soybean cultivar 3317361
A soybean cultivar designated 3317361 is disclosed. The invention relates to the seeds of soybean cultivar 3317361, to the plants of soybean 3317361, to plant parts of soybean cultivar 3317361, and to methods for producing a soybean plant produced by crossing soybean cultivar 3317361 with itself or with another soybean variety. The invention also relates to methods for producing a soybean plant containing in its genetic material one or more transgenes and to the transgenic soybean plants and plant parts produced by those methods. This invention also relates to soybean cultivars, or breeding cultivars, and plant parts derived from soybean variety 3317361, to methods for producing other soybean cultivars, lines or plant parts derived from soybean cultivar 3317361, and to the soybean plants, varieties, and their parts derived from use of those methods. The invention further relates to hybrid soybean seeds, plants, and plant parts produced by crossing the cultivar 3317361 with another soybean cultivar. |
| US08319024B2 |
Soybean cultivar S080021
A soybean cultivar designated S080021 is disclosed. The invention relates to the seeds of soybean cultivar S080021, to the plants of soybean S080021, to plant parts of soybean cultivar S080021, and to methods for producing a soybean plant produced by crossing soybean cultivar S080021 with itself or with another soybean variety. The invention also relates to methods for producing a soybean plant containing in its genetic material one or more transgenes and to the transgenic soybean plants and plant parts produced by those methods. This invention also relates to soybean cultivars, or breeding cultivars, and plant parts derived from soybean variety S080021, to methods for producing other soybean cultivars, lines or plant parts derived from soybean cultivar S080021, and to the soybean plants, varieties, and their parts derived from use of those methods. The invention further relates to hybrid soybean seeds, plants, and plant parts produced by crossing the cultivar S080021 with another soybean cultivar. |
| US08319016B1 |
Maize variety hybrid X8M172
A novel maize variety designated X8M172 and seed, plants and plant parts thereof, produced by crossing Pioneer Hi-Bred International, Inc. proprietary inbred maize varieties. Methods for producing a maize plant that comprises crossing hybrid maize variety X8M172 with another maize plant. Methods for producing a maize plant containing in its genetic material one or more traits introgressed into X8M172 through backcross conversion and/or transformation, and to the maize seed, plant and plant part produced thereby. This invention relates to the maize variety X8M172, the seed, the plant produced from the seed, and variants, mutants, and minor modifications of maize variety X8M172. This invention further relates to methods for producing maize varieties derived from maize variety X8M172. |
| US08319014B1 |
Maize variety hybrid X08A201
A novel maize variety designated X08A201 and seed, plants and plant parts thereof, produced by crossing Pioneer Hi-Bred International, Inc. proprietary inbred maize varieties. Methods for producing a maize plant that comprises crossing hybrid maize variety X08A201 with another maize plant. Methods for producing a maize plant containing in its genetic material one or more traits introgressed into X08A201 through backcross conversion and/or transformation, and to the maize seed, plant and plant part produced thereby. This invention relates to the maize variety X08A201, the seed, the plant produced from the seed, and variants, mutants, and minor modifications of maize variety X08A201. This invention further relates to methods for producing maize varieties derived from maize variety X08A201. |
| US08319012B2 |
Plants and seeds of hybrid corn variety CH337710
According to the invention, there is provided seed and plants of the hybrid corn variety designated CH337710. The invention thus relates to the plants, seeds and tissue cultures of the variety CH337710, and to methods for producing a corn plant produced by crossing a corn plant of variety CH337710 with itself or with another corn plant, such as a plant of another variety. The invention further relates to genetic complements of plants of variety CH337710. |
| US08319008B2 |
Categorically ranking animals for feed efficiency
The invention provides methods for managing livestock for breeding or production based on one or more measurements of mitochondrial function. Measurement of mitochondrial function may also be correlated with a calculated or known feed efficiency of livestock animals to yield a predicted feed efficiency for the animal. The invention overcomes deficiencies associated with phenotypic assays for predicted breeding and production value. |
| US08319007B2 |
Mouse models with enhanced essential tremor and preparation method thereof
Disclosed herein are an α1/CaV3.1 double knockout mouse or α1−/−; Emx1-Cre mouse with enhanced essential tremor and a screening method of therapeutic agents for essential tremor by using the same. The α1/CaV3.1 double knockout mouse or α1−/−; Emx1-Cre mouse of the present invention may be usefully used for development of therapeutic agents for essential tremor because the mouse exhibits essential tremor strong and evident enough to be visually confirmed, compared to an α1 knockout mouse. |
| US08319005B2 |
Comfortable diaper
An absorbent article, preferably a disposable absorbent article such as a diaper, is disclosed that provides an improved immobilization of absorbent polymer material when the article is fully or partially urine loaded. This absorbent core is useful for providing an absorbent article of increased wearing comfort. Specifically disclosed is an absorbent core useful for an absorbent article comprising a substrate layer and absorbent material, the absorbent material comprising an absorbent polymer material, the absorbent material optionally comprising absorbent fibrous material, the absorbent fibrous material not representing more than 20% of the weight of absorbent polymer material, wherein the absorbent material is immobilized when wet such that the absorbent core achieves a wet immobilization of more than 50%, preferably of more than 60%, 70%, 80% or 90% according to the Wet Immobilization Test described herein. |
| US08319002B2 |
Nanostructure-enhanced platelet binding and hemostatic structures
Methods, systems, and apparatuses for nanomaterial-enhanced platelet binding and hemostatic medical devices are provided. Hemostatic materials and structures are provided that induce platelet binding, including platelet binding and the coagulation of blood at a wound/opening caused by trauma, a surgical procedure, ulceration, or other cause. Example embodiments include platelet binding devices, hemostatic bandages, hemostatic plugs, and hemostatic formulations. The hemostatic materials and structures may incorporate nanostructures and/or further hemostatic elements such as polymers, silicon nanofibers, silicon dioxide nanofibers, and/or glass beads into a highly absorbent, gelling scaffold. The hemostatic materials and structures may be resorbable. |
| US08319001B2 |
Process for reacting ISO-alkane to make naphtha and middle distillate
A process for reacting an iso-pentane, comprising:a) partially converting an olefinic feedstock comprising at least 15 wt % iso-pentene to make a converted olefinic feedstock, wherein the iso-pentene is reduced and an amount of 2-pentene is retained; andb) alkylating the iso-pentane with the converted olefinic feedstock to make a naphtha and a middle distillate. |
| US08318987B2 |
Process for the preparation of lithium alcoholate solutions
The present invention relates to a process for the preparation of lithium alcoholates solution. |
| US08318984B2 |
Inducing cyathin A3 production
This invention provides a method of producing cyathin A3 in a culture of Cyathus helenae. It employs added bacteria to stimulate production of cyathin A3. |
| US08318978B2 |
Process for producing acrylic acid
The invention offers an improvement in a process for start-up in the occasion of producing acrylic acid by catalytically oxidizing acrolein at vapor phase under high load conditions, the start-up meaning the step of increasing the acrolein supply rate (loading) from the non-reacting condition to the prescribed reaction conditions. This process is characterized in that the acrolein supply rate is increased in the start-up stage of the reaction until the prescribed composition of starting reactant gas and the flow rate of the starting reactant gas are obtained, while adjusting at least one of the reaction temperature, the composition of the starting reactant gas and the flow rate of the starting reactant gas, so as to maintain the acrolein conversion at not lower than 90 mol %, the maximum peak temperature of the catalyst layer in each reaction zone at no higher than 400° C., and the sum of each ΔT (maximum peak temperature of a catalyst layer-reaction temperature) at the catalyst layer in each of the reaction zones to be no more than 150° C., respectively. According to this process, the reaction speedily reaches the steady state (standard operating conditions) and a high acrylic acid yield is stably achieved from the start of the reaction. |
| US08318976B2 |
Salts, aqueous liquid compositions containing salts of S-(+)-abscisic acid and methods of their preparation
The present invention generally relates to salts of S-(+)-abscisic acid, aqueous liquid compositions containing salts of S-(+)-abscisic acid and methods of their preparation for agricultural use. |
| US08318975B2 |
Methods for producing phenylalanine derivatives having a quinazolinedione skeleton and intermediates for production thereof
The present invention provides a method for producing a phenylalanine derivative(s) having a quinazolinedione ring of formula (5), including steps comprising of reacting an acylphenylalanine derivative(s) of formula (1) with a carbonyl group-introducing reagent(s) and a derivative(s) of anthranilic acid to form an asymmetric urea intermediate(s); making the asymmetric urea intermediate(s) into a quinazolinedione compound(s) of formula (4) in the presence of a base(s); and N-alkylating quinazolinedione ring amide of the obtained quinazolinedione compounds with N-alkylation agents. This production method is an industrially applicable method for producing phenylalanine derivatives having a quinazolinedione skeleton, which are compounds highly useful as drugs having α 4 integrin inhibiting activity. In the formulae (1) and (5), R1 represents a phenyl group having a substituent(s) and the like, R2 represents an alkyl group and the like, R3 represents a dialkylamino group and the like, and R4 represents an alkyl group and the like. |
| US08318971B2 |
Process for preparing methylenediphenyl diisocyanates
The invention relates to a process for preparing methylenediphenyl diisocyanates which comprises at least the steps: A) reaction of aniline with formaldehyde in the presence of hydrochloric acid as catalyst to give a mixture of diamines and polyamines of the diphenylmethane series (MDA) and subsequent at least partial neutralization of the hydrochloric acid by means of alkali metal hydroxide, B) reaction of the mixture of diamines and polyamines of the diphenylmethane series obtained in step A) with phosgene to give a mixture of diisocyanates and polyisocyanates of the diphenylmethane series (MDI) and hydrogen chloride, wherein C) the hydrochloric acid which has been neutralized in step A) is separated off in the form of a solution containing alkali metal chloride and is subsequently at least partly fed to an electrochemical oxidation to form chlorine, alkali metal hydroxide and optionally hydrogen and D) at least part of the chlorine produced in step C) is used for preparing the phosgene used in step B). |
| US08318969B2 |
Alignment material for liquid crystal display device of vertical alignment mode and method of preparing the same
This invention provides alignment materials for liquid crystal display device of vertical alignment mode and methods for the preparation of the same, and more particularly, it provides diaminobenzene derivatives represented by the following formula 1: wherein n is an integer of 1 to 5 and R is an alkyl or alkoxy group of 3 to 5 carbon atoms, which align liquid crystal in uniform and vertical way, have not only excellent mechanical properties such as heat resistance and surface strength but also high pretilt angles of liquid crystal and in particular, can make response rate of liquid crystal fast, methods for the preparation of the same and liquid crystal alignment films using the same. |
| US08318967B2 |
Polysilane-supported transition metal catalyst for liquid phase reaction
The present invention provides a polysilane-supported transition metal catalysts or a polysilane/inorganic compound-supported transition metal catalysts, wherein various types of transition metals are supported by polysilane compounds, or combination of polysilanes and inorganic compounds. The catalysts of the present invention are hardly soluble in hydrocarbons and alcohols and are useful as catalysts in heterogeneous system for various organic synthetic reactions using the above solvents. Polysilanes supporting transition metals are easily crosslinkable by thermal treatment, microwave irradiation, UV irradiation or chemical methods such as hydrosilylation reaction and are changed to be insoluble in various solvents keeping high catalytic activity. Moreover, the stability and operability of polysilane-supported transition metal catalysts will be improved by the support thereof on inorganic compounds. These polysilane-supported transition metal catalysts show a high catalytic activity in hydrogenation reaction, hydrosilylation reaction, Heck reaction, Suzuki-Miyaura coupling reactions and the like. The catalyst is easily recoverable and reusable and the leakage of metals is extremely few. |
| US08318966B2 |
Organometallic compounds
This invention relates to organometallic compounds represented by the formula HaM(NR1R2)x(NR3H)y(NH2)z wherein M is a metal or metalloid, each of R1, R2 and R3 is the same or different and is independently a hydrocarbon group or a heteroatom-containing group, a is a value from 0 to 3, x is a value from 0 to 3, y is a value from 0 to 4, z is a value from 0 to 4, and a+x+y+z is equal to the oxidation state of M, provided that at least one of y and z is a value of at least 1, a process for producing the organometallic compounds, and a method for producing a film or coating from organometallic precursor compounds. |
| US08318964B2 |
Process for producing ester compound
ProblemTo provide an environmentally-friendly method for producing industrially an ester compound.SolutionThe present invention is a method for producing an ester compound which comprises subjecting a carboxylic acid and an alcohol to dehydration-condensation reaction using an involatile acid catalyst and then removing the residual acid catalyst by bringing a weak basic substance into contact with the residual acid catalyst. |
| US08318959B1 |
Synthesis and polymerization of glycidyl ethers
The method of preparing novel allyl ethers.Novel glycidyl ethers and their preparation.Polyfunctional poly(glycidyl ethers) their methods of preparation.Novel polyurethanes based on the polyfunctional glycidyl ethers and their method of preparation. |
| US08318958B2 |
Oxidizing agent composition for epoxidation and oxidation method thereof
Disclosed is a method for epoxidizing olefins, which enables an epoxy compound containing no halogen atom with high yield. Specifically disclosed is an oxidizing agent composition for epoxidation of olefins, which is characterized by containing peroxide which exhibits basicity when dissolved in water and an acid anhydride. |
| US08318956B2 |
Spiroheterocyclic tetronic acid derivatives
The present invention relates to novel compounds of the formula (I), in which W, X, Y, Z, G, A and t have the meanings given above, to a plurality of processes and intermediates for their preparation and to their use as pesticides and/or herbicides. Moreover, the invention relates to selective herbicidal compositions comprising, firstly, the spiroheterocyclic tetronic acid derivates and, secondly, a crop plant compatibility-improving compound.The present invention furthermore relates to increasing the activity of crop protection compositions comprising in particular phenyl-substituted bicyclooctane-1,3-dione derivates by adding ammonium salts or phosphonium salts and, if appropriate, penetrants, to the corresponding compositions, to processes for their preparation and to their use in crop protection as insecticides and/or acaricides and/or for preventing unwanted plant growth. |
| US08318954B2 |
Cleavable carnitine compound
The invention includes novel compounds, including but not limited to formula A and formula B, and an improved delivery method. These compounds and methods are useful in preventing or treating diseases or conditions associated with or caused by the presence of free radicals, and are useful for increasing cellular metabolism while simultaneously alleviating the resultant increase in oxidative stress. Specifically, a carnitine is bound to a lipoic acid derivative or to dihydrolipoic acid or its derivatives using a hydrolysable linker to form a single compound. |
| US08318952B2 |
Substituted indole derivatives for the treatment of respiratory diseases
The present invention relates to a compound of formula (I) (wherein all symbols have the same meanings as described hereinbefore). The compound antagonizes cysLT2 and therefore, it is useful as an agent for the prevention and/or treatment of respiratory diseases such as bronchial asthma, bronchial asthma, chronic obstructive pulmonary disease, pneumonectasia, chronic bronchitis, pneumonia (e.g. interstitial pneumonitis etc.), severe acute respiratory syndrome (SARS), acute respiratory distress syndrome (ARDS), allergic rhinitis, sinusitis (e.g. acute sinusitis, chronic sinusitis, etc.), and the like, or as an expectorant or antitussives. |
| US08318947B2 |
Comestible compositions comprising high potency savory flavorants, and processes for producing them
The present invention relates to the use of certain high potency savory (‘umami’) taste modifiers, as savory flavoring agents and/or enhancers of monosodium glutamate, for the preparation of foods, beverages, and other comestible compositions, and to processes for preparing food flavorant compositions for use in the preparation of comestible food and drink. |
| US08318946B2 |
Process for the preparation of 2-substituted-5-(1-alkylthio)alkylpyridines
2-Substituted-5-(1-alkylthio)alkylpyridines are produced efficiently and in high yield. |
| US08318945B2 |
Metalloprotein inhibitors
The present invention relates to metalloprotein inhibitors comprising: a. an organic substituent and at least one zinc binding group (ZBG) covalently attached thereto; or b. a ZBG substituted by a side chain wherein the ZBG is of formula (I): wherein X is O or S and each R1, R2, R3, and R4 is individually hydrogen or an organic radical. The metalloprotein inhibitors are useful for preventing or treating a pathological disease, condition, or symptom that is associated with pathological metalloprotein activity and/or that is alleviated by inhibition of said activity. |
| US08318939B2 |
Kinase inhibitors
Compounds, pharmaceutical compositions, kits and methods are provided for use with kinases that comprise a compound selected from the group consisting of: wherein the variables are as defined herein. |
| US08318938B2 |
Trans-fused chromenoisoquinolines synthesis and methods for use
Optionally substituted chromenoisoquinolines and analogs and derivatives thereof are described herein. In addition, syntheses of these compounds are described herein. In addition, uses of these compounds as dopamine receptor binding compounds are described herein. |
| US08318936B2 |
Method for producing N-methylnaltrexone bromide
Process for the preparation of N-methylnaltrexone bromide, wherein a compound of the general formula (I): wherein X− represents an anion other than the bromide anion, and R represents hydrogen or a leaving group, is dissolved or dispersed in a suitable polar solvent, the solution or dispersion is mixed with a compound containing bromide anions, and the resulting reaction mixture is stirred until N-methylnaltrexone bromide has formed and crystallized, wherein, in the case where R represents a leaving group, that group is removed during or after the reaction. |
| US08318934B2 |
Process for chiral resolution of 2-substituted 4-substituted 1,3-oxathiolanes
The present invention relates to a novel process for the chiral resolution of 2-substituted 4-substituted 1,3-oxathiolanes and derivatives thereof. The present invention also relates to novel 2-substituted 4-substituted 1,3-oxathiolanes derivatives. |
| US08318932B2 |
Process for producing 4-aminoquinazoline compound
A 4-aminoquinazoline derivative can be obtained by the steps of reacting quinazolin-4-one or its derivative with a chlorinating agent in a first organic solvent in the presence of an organic base, and subsequently reacting the reaction product with an amine compound represented by the formula R5—NH—R6 (each of R5 and R6 represents hydrogen or an optionally substituted hydrocarbyl group) in the presence of a second organic solvent. |
| US08318931B2 |
Chemokine receptor antagonists and use thereof
The present invention relates to a compound represented by formula (I): wherein all symbols are as defined here, a salt thereof, a solvate thereof, or a prodrug thereof. The compound of the present invention has an antagonistic activity against CXCR4 and is therefore useful as a preventive and/or therapeutic agent for CXCR4-mediated diseases, for example, inflammatory and immune diseases (for example, rheumatoid arthritis, arthritis, retinopathy, pulmonary fibrosis, rejection of transplanted organ, etc.), allergic diseases, infections (for example, human immunodeficiency virus infection, acquired immunodeficiency syndrome, etc.), psychoneurotic diseases, cerebral diseases, cardiovascular disease, metabolic diseases, and cancerous diseases (for example, cancer, cancer metastasis, etc.), or an agent for regeneration therapy. |
| US08318927B2 |
6-(4-cyclopropylpiperazin-1-yl)-2′-methyl-[3, 4′]-bipyridine and its uses as a medicament
6-(4-Cyclopropylpiperazin-1-yl)-2′-methyl-[3,4′]bipyridinyl and salts and hydrates thereof interact with the histamine H3 receptor are defined. |
| US08318926B2 |
Anti-MicroRNA oligonucleotide molecules
The invention relates to isolated anti-microRNA molecules. In another embodiment, the invention relates to an isolated microRNA molecule. In yet another embodiment, the invention provides a method for inhibiting microRNP activity in a cell. |
| US08318922B2 |
Treatment and prevention of hyperproliferative conditions in humans and antisense oligonucleotide inhibition of human replication-initiation proteins
Antisense oligonucleotides that inhibit expression of human replication-initiation protein as well as methods of preventing or treating hyperproliferative conditions using said oligonucleotides are disclosed. One aspect provides an antisense oligonucleotide that inhibits the expression of human replication-initiation protein and has a sequence complementary to at least a portion of a target sequence encoding a human replication-initiation gene. By administering a therapeutically effective amount of an antisense oligonucleotide or by contacting the hyperproliferating cells with an effective amount of one or more antisense oligonucleotides, expression of replication-initiation protein is inhibited. Methods of screening and testing active antisense oligonucleotides for their ability to inhibit gene expression are also disclosed. |
| US08318920B2 |
Therapeutic nucleic acid-3′-conjugates
Methods are described for improvement of the serum half life of therapeutic nucleic acids by 3′ conjugation to useful target proteins, or other large molecules with useful function. In one embodiment, a 3′ A, C or G overhang is added to ds-DNA and the primary amines conjugated using biocompatible bifunctional linkers to proteins. The resulting nucleic acid-3′-conjugates are serum nuclease-resistant and retained in vivo for long periods without rapid kidney clearance. Further, the choice of conjugate imparts additional functionality to the nucleic acid-3-conjugate. |
| US08318917B2 |
Nucleic acids encoding antibodies having altered effector function and methods for making the same
The invention provides a method of producing aglycosylated Fc-containing polypeptides, such as antibodies, having desired effector function. The invention also provides aglycosylated antibodies produced according to the method as well as methods of using such antibodies as therapeutics. |
| US08318916B2 |
Human CTLA-4 antibodies and their uses
The present invention provides novel human sequence antibodies against human CTLA-4 and methods of treating human diseases, infections and other conditions using these antibodies. |
| US08318906B2 |
EMP2 antibodies and their therapeutic uses
The present invention provides methods and compositions useful in the treatment or prevention of Chlamydia infections and cancer. The methods and compositions inhibit the entry of Chlamydia into a host cell expressing EMP2 by interfering with the interaction between the Chlamydia and EMP2. The methods and compositions target cancers which express or overexpress EMP2 nucleic acids and polypeptides by targeting EMP2. |
| US08318904B2 |
Liquid, aqueous pharmaceutical compositions of factor VII polypeptides
The present invention is directed to liquid, aqueous pharmaceutical compositions stabilized against chemical and/or physical degradation containing Factor VII polypeptides, and methods for preparing and using such compositions, as well as vials containing such compositions, and the use of such compositions in the treatment of a Factor VII-responsive syndrome. The main embodiment is represented by a liquid, aqueous pharmaceutical composition comprising at least 0.01 mg/mL of a Factor VII polypeptide (i); a buffering agent (ii) suitable for keeping pH in the range of from about 4.0 to about 9.0; and at least one stabilizing agent (iii) comprising a —C(═N—Z1—R1)—NH—Z2—R2 motif, e.g. benzamidine compounds and guanidine compounds such as arginine. |
| US08318900B2 |
Pesticidal proteins and methods for their use
Compositions and methods for conferring pesticidal activity to bacteria, plants, plant cells, tissues and seeds are provided. Compositions comprising a coding sequence for a toxin polypeptide are provided. The coding sequences can be used in DNA constructs or expression cassettes for transformation and expression in plants and bacteria. Compositions also comprise transformed bacteria, plants, plant cells, tissues, and seeds. In particular, isolated toxin nucleic acid molecules are provided. Additionally, amino acid sequences corresponding to the polynucleotides are encompassed, and antibodies specifically binding to those amino acid sequences. In particular, the present invention provides for isolated nucleic acid molecules comprising nucleotide sequences encoding the amino acid sequence shown in SEQ ID NO:50-96, or the nucleotide sequence set forth in SEQ ID NO:1-47, as well as variants and fragments thereof. |
| US08318898B2 |
Synthetic peptides for use as inhibitors of neurotransmitter secretion and as inducers of cellular relaxation
The present invention describes materials and methods related to synthetic peptides which block the secretion of neurotransmitters and induce muscle relaxation, and use of said peptides as inhibitors of neurotransmitter secretion and muscle contraction, and as inducers of muscle relaxation. |
| US08318894B2 |
Charged polymers and their uses in electronic devices
The present invention generally relates to compositions and methods comprising charged polymers. The compositions can be used in a variety of applications, for example, in photovoltaic cells, field-effect transistors, and light emitting diodes. In some embodiments, the backbone of a charged polymer comprises at least one quaternary nitrogen and/or is conjugated. |
| US08318893B2 |
Aliphatic polyester resin and its production method
An aliphatic polyester resin having excellent moldability and its production method are provided. When the amount of specific structural units contained in an aliphatic polyester resin is adjusted to an optimum amount, an aliphatic polyester resin having sufficient melt tension at the time of molding and excellent moldability than in the past and its production method is provided. |
| US08318888B1 |
Two-photon absorbing cross-linked polyurethanes containing delphenylamino-dialkyffluorene-1,3,5-triazine units
Two-photon absorbing (2PA), cross-linked polyurethanes were prepared from bis(isocyanato) monomers, tris(isocyanato) monomers or a mixture of bis(isocyanato) and tris(isocyanato) monomers, in conjunction with a novel polyol molecules with donor-acceptor octupolar geometry, whose generic structure is comprised of an electron-accepting 1,3,5-triazine hub with three spokes constituted by electron-donating triarylalkylamine end-groups, which are polyfunctionalized with thermally reactive alcohol functions. The resulting neat glassy or rubbery solids are applicable in a wide range of linear & nonlinear optical applications. |
| US08318884B2 |
Process for producing coloured polypropylene composition having a high content of β-modification
The invention relates to a novel process for producing coloured polypropylene compositions having a high content of β-modification, wherein polypropylene is melt blended with at least one inorganic pigment and at least one β-nucleating agent, wherein a1) polypropylene is melt blended with at least one inorganic pigment or with a first concentrate comprising the at least one inorganic pigment to obtain a coloured polypropylene and a2) the coloured polypropylene is melt blended with at least one β-nucleating agent or with a second concentrate comprising the at least one β-nucleating agent to obtain the coloured β-nucleated polypropylene composition or b1) polypropylene is melt blended with at least one β-nucleating agent or with a second concentrate comprising the at least one β-nucleating agent to obtain a β-nucleated polypropylene and b2) the β-nucleated polypropylene is melt blended with at least one inorganic pigment or with a first concentrate comprising the at least one inorganic pigment to obtain the coloured β-nucleated polypropylene composition or c) a third concentrate is produced by melt blending a first concentrate comprising the at least one inorganic pigment and a second concentrate comprising the at least one β-nucleating agent and the polypropylene is melt blended with the third concentrate to produce the coloured β-nucleated polypropylene composition or d) a first concentrate comprising the at least one inorganic pigment and a second concentrate comprising the at least one β-nucleating agent are melt blended with the polypropylene to obtain the coloured β-nucleated polypropylene composition. |
| US08318883B1 |
Polymer compositions for blow molding applications
A polymer having a density of from about 0.960 g/cc to about 0.965 g/cc and a melt index of from about 0.2 g/10 min. to about 0.6 g/10 min. wherein an article formed from the polymer has an environmental stress crack resistance of equal to or greater than about 150 hours when measured in accordance with ASTM D 1693 condition B, 100% Igepal. A polymer having a density of from about 0.955 g/cc to about 0.960 g/cc and a melt index of from about 0.2 g/10 min. to about 0.6 g/10 min. wherein an article formed from the polymer has an environmental stress crack resistance of equal to or greater than about 500 hours when measured in accordance with ASTM D 1693 condition B, 100% Igepal. |
| US08318880B2 |
Anionic water-soluble additives
The invention relates to anionically modified copolymers that can be produced by the polymerization of monomers (A), (B) and (C) to obtain non-ionic polymers with reactive terminal OH groups and by the subsequent reaction of the terminal OH groups to form anionic end groups. According to the invention, (A) is a monomer of formula (I), in which A represents C2-C4 alkene and B represents a C2-C4 alkene that is different from A, R represents hydrogen or methyl, m is a number between 1 and 500, n is a number between 1 and 500, (B) is an ethylenically unsaturated monomer containing an aromatic group and (C) is a ethylenically unsaturated monomer. |
| US08318879B2 |
High solids content solutions of organosilicone copolymers with high silicone content and high solids content, and process for preparation thereof, and use thereof
The invention relates to soliconorganocopolymers with high silicon content, with a silicon content of ≧25 wt. % in form of a high solid content solution thereof, with a solid content of >30 wt. %, obtainable with radically initiated solution polymerization of a) 20 to 75 wt. % of one or more ethylenic unsaturated monomers, and b) 25 to 80 wt. % of one or more silicones of the general formula R1aR3−aSiO(SiR2O)nSiR3−aR1a, wherein R is equal or different, and refers to a monovalent, possibly substitutes, alkyle- or alkoxy group with 1 to 18 C-atoms, R1 refers to a polymerizable group, a is 0 or 1 and n=10 to 1000, wherein 85 to 100 wt. % of the silicones b) contain one or two polymerizable groups, wherein silicones b) with only one polymerizable group only in the mixture with silicones b) with two polymerizable groups and in a weight ratio <50/50 are used, wherein the wt. %-indications for the components a) to b) refer to the whole weight of the used monomers and add up to 100 wt. %, characterized in that the polymerization is carried out in a solvent or solvent mixture, wherein silicon b) comprises a solubility of less than 5 wt. % under normal conditions. |
| US08318878B2 |
Benzoxazine-containing formulations polymerizable/curable at low temperature
The present invention relates to a catalyst, which is an organic component with electron withdrawing substituents and to compositions with such catalyst and at least one benzoxazine component, and the use of such compositions in adhesives, sealants and coatings. |
| US08318877B2 |
Ethylene tetrafluoroethylene (meth)acrylate copolymers
A copolymer composition comprising monomers copolymerized in the following percentages by weight: (a) from about 20% to about 95% of a monomer, or mixture of monomers, of formula (I): CnF2n+1(CH2)x[(CF2CF2)y(CH2CH2)z]m-L-C(O)—C(R)═CH2 (I) wherein R is H, Cl, F or CH3, L is O, S, NH, S—(CH2)rO, S—(CH2)rNH, OC(O)NH—CH2CH2O, NHC(O)NHCH2CH2O, S—(CH2)rOC(O)NHCH2CH2O, or S(CH2)rNHC(O)NHCH2CH2O, and (b) from about 5% to about 80% of at least one of: (i) an alkyl (meth)acrylate monomer having a linear, branched or cyclic alkyl group of from about 6 to about 18 carbons; or (II) a monomer of formula (II) (R2)2N—R3—O—C(O)—C(R)═CH2 (II) wherein R is H, Cl, F or CH3, each R2 is independently a C1 to C4 alkyl; and R3 is a divalent linear or branched C1 to C4 alkylene; and wherein the nitrogen is from about 40% to 100% salinized; or (iii) a mixture thereof. |
| US08318875B2 |
Super-solution homogeneous propylene polymerization and polypropylenes made therefrom
This invention relates to processes for producing an isotactic propylene homopolymer having more than 15 and less than 100 regio defects (sum of 2,1-erythro and 2,1-threo insertions and 3,1-isomerizations) per 10,000 propylene units; a weight-averaged molecular weight of 35000 g/mol or more; a peak melting temperature of greater than 149° C.; an mmmm pentad fraction of 0.85 or more; a heat of fusion of 80 J/g or more; and a peak melting temperature minus peak crystallization temperature (Tmp−Tcp) of less than or equal to (0.907 times Tmp) minus 99.64 (Tmp−Tcp<(0.907×Tmp)−99.64), as measured in ° C. on the homopolymer having 0 wt % nucleating agent. |
| US08318870B2 |
Epoxide (meth) acrylate composition
The disclosure relates to a composition having at least one radically polymerisable monomer M; at least one radical former, at least one epoxide resin A including an average of more than one epoxide group per molecule, and at least one compound of formula (I). Such compositions are suitable as adhesives, sealants or coatings. Shortly after the application thereof, they have a high initial strength and, after further hardening at room temperature, they reach a high level of final strength. |
| US08318869B2 |
Fluorinated polyurethane composition
A composition useful for imparting durable stain repellence and soil release properties to textile substrates, a method for treating textile substrates using such composition, and the textile substrates obtained therefrom. The composition comprises: (A) at least one fluorinated ionisable polyurethane polymer (PUR) being free from perfluoroalkyl chains and comprising at least one fluorinated block comprising a fluoropolyoxyalkene chain, and at least one functional block comprising an hydrocarbon chain (RHC) having from 2 to 14 carbon atoms, said chain (RHC) comprising at least one ionisable group, said blocks being linked by urethane moieties of formula (I), wherein E is a divalent hydrocarbon carbon group; (B) at least one fluorocarbon polymer (F) comprising at least one perfluoroalkyl chain (Rf) linked by one or more ester moiety of formula (II) and/or urethane moiety of formula (III) and/or urea moiety of formula (IV); and (C) at least one crosslinking agent. |
| US08318867B2 |
Thermally stable biuret and isocyanurate based surface modifying macromolecules and uses thereof
The invention relates to surface modifying macromolecules (SMMs) having high degradation temperatures and their use in the manufacture of articles made from base polymers which require high temperature processing. The surface modifier is admixed with the base polymer to impart alcohol and water repellency properties. |
| US08318866B2 |
Polyoxymethylene molding materials and moldings and the use thereof
Molding materials and the moldings produced therefrom, containing a) polyoxymethylene in which at least 50% of the terminal groups are hydroxyl groups, which has a melt volume rate MVR of less than 20 cm3/10 minutes, measured according to ISO 1133 at 190° C. and 2.16 kg, and whose proportion of low molecular weight constituents having low molecular weights below 10 000 dalton is less than 15% by weight, based on the total mass of the polyoxymethylene, and b) a thermoplastic elastomer, are described.The moldings produced from these molding materials are distinguished by a very high notch impact strength. |
| US08318864B2 |
Functionalized ethylene/α-olefin interpolymer compositions
The invention relates to functionalized interpolymers derived from base olefin interpolymers, which are prepared by polymerizing one or more monomers or mixtures of monomers, such as ethylene and one or more comonomers, to form an interpolymer products having unique physical properties. The functionalized olefin interpolymers contain two or more differing regions or segments (blocks), resulting in unique processing and physical properties. |
| US08318857B2 |
Impact-modified polycarbonate compositions
The present invention relates to filled, impact-modified polycarbonate compositions containing A) aromatic polycarbonate and/or aromatic polyester carbonate, B) a first graft polymer of B.1 from 0.1 to 30 wt. % of at least one vinyl monomer on B.2 from 99.9 to 70 wt. % of one or more graft bases having glass transition temperatures <10° C., the graft base consisting of at least 50 wt. % of a silicone rubber, C) a second graft polymer, which is different from component B, of C.1 from 5 to 95 wt. % of at least one vinyl monomer on C.2 from 95 to 5 wt. % of one or more graft bases having glass transition temperatures <10° C., the graft base consisting of at least 50 wt. % of an EPDM rubber, D) rubber-free vinyl (co)polymer and/or polyalkylene terephthalate, and E) polymer additives, wherein components B and C are present in a ratio (B:C) in the range from 20:80 to 80:20 and wherein the composition contains from 10 to 92 parts by weight of component A, from 8 to 90 parts by weight of the sum of components B and C, from 0 to 35 parts by weight of component D, and from 0 to 30 parts by weight of component E, which have good stability to ageing and which are distinguished by high low-temperature strength and by low gloss, to a process for their production and to their use in the production of molded bodies. |
| US08318856B2 |
Nucleic acid delivery system comprising conjugates of PEI and hyaluronic acid
The present invention relates to a delivery system for nucleic acid using a cationic polymer conjugate, and more specifically relates to a delivery system for nucleic acid comprising a cationic polymer conjugate prepared by conjugating hyaluronic acid or its derivative and polyethyleneimine, and a composition of delivering a nucleic acid into mammalian cell comprising a complex of the nucleic acid and a cationic polymer conjugate with electrostatic binding. |
| US08318854B2 |
Composition for thermosetting silicone resin
The present invention relates to a composition for a thermosetting silicone resin, including: (1) an organopolysiloxane having a silanol group at an end thereof; (2) an alkenyl group-containing silicon compound; (3) an epoxy group-containing silicon compound; (4) an organohydrogensiloxane; (5) a condensation catalyst; (6) a hydrosilylation catalyst; and (7) a silica particle, in which the (7) silica particle has a 50% volume cumulative diameter of from 2 to 50 μm, a content of particles having a particle size of 1 μm or less of 15% by number or less and a content of particles having a particle size of 60 μm or more of 15% by number or less. |
| US08318852B2 |
Acrylic pressure-sensitive adhesive composition for polarizing film
The present invention relates to an acrylic pressure sensitive adhesive composition comprising (meth)acrylic copolymers including alkyl(meth)acrylic acid ester monomer having 2˜14 carbon atoms of alkyl group, characterized in that the gel fraction is 10˜55%, the swelling ratio is 30˜110, the weight average molecular weight of sol eluted from the final adhesive by ethyl acetate is at least 800,000, comprising low molecular weight molecule having the maximum 100,000 of weight average molecular weight by 10 ˜40 wt % of the total sol component; and the above composition show excellent durability under a high temperature and/or humidity condition, and can improve the light leakage phenomenon and provide excellent operability at the time of manufacturing polarizer by effectively providing high modulus and stress release property. |
| US08318850B2 |
Cured perfluoroelastomer article
Cured perfluoroelastomers that contain high levels (i.e. at least 65 phr carbon black) and 1 to 15 phr of a perfluoropolyether exhibit good resistance to explosive decompression while maintaining good sealing properties. |
| US08318843B2 |
Laser-transparent polyesters
Use of thermoplastic molding compositions comprising, as essential components, A) from 29 to 99.95% by weight of a polyester, B) from 0.05 to 2.0% by weight of Na2CO3, K2CO3, NaHCO3, KHCO3, or a mixture of these, based on 100% by weight of A) and B), and also C) from 0 to 70% by weight of further additives, where the total of the % by weight values for A) to C) is 100%, for producing laser-transparent moldings of any type. |
| US08318838B2 |
Method of forming polymer nanocomposite
A method for making a polymer composite comprises mixing, a thermosetting polymer precursor, and 0.01 to 30 wt % of a derivatized nanoparticle based on the total weight of the polymer composite, the derivatized nanoparticle including functional groups comprising carboxy, epoxy, ether, ketone, amine, hydroxy, alkoxy, alkyl, aryl, aralkyl, alkaryl, lactone, functionalized polymeric or oligomeric groups, or a combination comprising at least one of the forgoing functional groups. |
| US08318836B2 |
Liquid hardening
Curing agents for air-drying alkyd-based resins, coatings, such as paint, varnish or wood stain, inks and linoleum floor coverings, based on an iron/manganese complex containing tetradentat, pentadentate or hexadentate nitrogen donor ligands are disclosed. |
| US08318835B2 |
Material to be injection molded, process thereof, and use therefore
The present invention refers to an adequate composite material to be prepared by an injection process and to an injection process of a composite material. In accordance with the process of the present invention, the composite material is prepared by carrying out the steps of (i) making the length of the natural fibers uniform; (ii) treating the surface of the natural fibers and of the lignocellulosic residues, if present; (iii) premixing the components of the composite; (iv) extruding and granulating the composite material; and (v) injection molding the material of the composite for the conformation of the parts. |
| US08318831B2 |
Hydrophilized curable silicone impression materials with improved storage behavior
The invention relates to hydrophilized curable silicone compositions which contain organopolysiloxanes, hydrophilizers and at least one stabilizing phosphorous compound. The compositions are particularly suitable as curable impression materials in dental applications, especially as wash impression materials. |
| US08318826B2 |
Ortho-cyclohexanediamine-initiated polyols and rigid polyurethane foam made therefrom
Polyether polyols are initiated with orthocyclohexanediamines such as 1,2-diaminocyclohexane. The polyols are useful in making rigid polyurethane foams, especially foams for pour-in-place applications, where they give a good combination of low k-factor and short demold times. |
| US08318825B2 |
Polishing pad and method of producing the same
The invention provides a polishing pad by which optical materials such as lenses, reflecting mirrors etc., or materials requiring a high degree of surface planarity, as in the polishing of silicone wafers, glass substrates or aluminum substrates for hard disks, or general metal polishing, can be flattened with stability and high polishing efficiency. The invention also provides a polishing pad for semiconductor wafers, which is superior in planarizing characteristic, is free from scratches and can be produced at low cost. There is provided a polishing pad which is free from dechucking error so that neither damage to wafers nor decrease in operating efficiency occurs. There is provided a polishing pad which is satisfactory in planarity, within wafer uniformity, and polishing rate and produces less change in polishing rate. There is provided a polishing pad which can make planarity improvement and scratch decrease compatible. |
| US08318819B2 |
Compositions for compounding foamable, fluropolymer pellets for use in melt processing cellular or foamed fluoropolymer applications
The disclosure provides a composition as well as a set of compositions and method for producing cellular or foamed or blown fluoropolymers such as perfluoropolymers and other thermoplastics articles allowing for the creation of a lower cost communications cable, conductor separator, conductor support-separator, jacketing, tape, wire insulation and in some cases a conduit tube as individual components or combined configurations that exhibit improved electrical, flammability and optical properties. Specifically, the foamable or blown fluoropolymer such as a perfluoropolymer cellular insulation composition comprises; talc and the selected fluoropolymer such as perfluoropolymers. Compounded pellets or products resulting in cellular or foamable products using these pellets has also been realized by providing the melt combination in the pellets of only talc and a perfluoropolymer. |
| US08318817B2 |
Controlled release antimicrobial compositions and methods for the treatment of otic disorders
Disclosed herein are compositions and methods for the treatment of otic diseases or conditions with antimicrobial agent compositions and formulations administered locally to an individual afflicted with an otic disease or condition, through direct application of these compositions and formulations onto or via perfusion into the targeted auris structure(s). |
| US08318816B2 |
Enhanced transport using membrane disruptive agents
Compositions and methods for transport or release of therapeutic and diagnostic agents or metabolites or other analytes from cells, compartments within cells, or through cell layers or barriers are described. The compositions include a membrane barrier transport enhancing agent and are usually administered in combination with an enhancer and/or exposure to stimuli to effect disruption or altered permeability, transport or release. In a preferred embodiment, the compositions include compounds which disrupt endosomal membranes in response to the low pH in the endosomes but which are relatively inactive toward cell membranes (at physiologic pH, but can become active toward cell membranes if the environment is acidified below ca. pH 6.8), coupled directly or indirectly to a therapeutic or diagnostic agent. Other disruptive agents can also be used, responsive to stimuli and/or enhancers other than pH, such as light, electrical stimuli, electromagnetic stimuli, ultrasound, temperature, or combinations thereof. The compounds can be coupled by ionic, covalent or H bonds to an agent to be delivered or to a ligand which forms a complex with the agent to be delivered. Agents to be delivered can be therapeutic and/or diagnostic agents. Treatments which enhance delivery such as ultrasound, iontopheresis, and/or electrophereis can also be used with the disrupting agents. |
| US08318813B2 |
Method of treating binge eating disorder
The invention provides methods of treating binge eating disorders, obesity resulting from binge eating behavior, and depression. The invention includes methods of treating certain co-morbidities in ADHD and ADD patients; for example the invention includes methods of treating generalized anxiety disorder, obsessional and ruminative thought disorders, and obsessive/compulsive behavior in ADHD and ADD patients. The invention also includes combination methods of treatment in which an amphetamine prodrug, methylphenidate prodrug, or methylphenidate analog is administered with one or more other active agents. Packaged pharmaceutical compositions containing an amphetamine or methylphenidate prodrug, instructions for using the prodrug to treat certain disorders, and optionally one or more other active agents are provided by the invention. |
| US08318810B2 |
Methods for treating neural cell swelling
A composition comprising a novel Ca2+-activated, [ATP]i-sensitive nonspecific cation (NCCa-ATP) channel is described. The channel is found in mammalian neural cells and exhibits a different sensitivity to block by various adenine nucleotides, and is activated by submicromolar [Ca]i. The NCCa-ATP channel is activated under conditions of ATP depletion, which causes severe cell depolarization, followed by cell swelling. The NCCa-ATP channel is regulated by a sulfonylurea receptor and is inhibited by sulfonylurea compounds glibenclamide and tolbutamide. Methods employing compositions comprising the NCCa-ATP channel to screen for compounds that block the channel and the use of such antagonists as therapeutics in preventing brain swelling and damage are described. In addition, methods employing compositions comprising the Kir2.3 channel to screen for compounds that open the channel and the use of such antagonists as therapeutics in preventing brain swelling and damage are described. |
| US08318809B2 |
Compositions and methods for treating jellyfish stings
Methods and compositions for treating skin conditions, in particular jellyfish stings, are provided. |
| US08318802B2 |
Epoprostenol formulation and method of making thereof
This invention relates to a stable epoprostenol composition that can be combined with commercially available IV fluids and can be administered in its reconstituted and/or diluted form under ambient conditions of about 15-30° C. for greater than 24 hours. The composition preferably contains (a) epoprostenol or a salt thereof; (b) a alkalinization agent; and (c) a base, such that when reconstituted or in solution, the solution has a pH>11. Methods for making the lyophilized composition are also disclosed. |
| US08318801B2 |
Cinnamic compounds and derivatives therefrom for the inhibition of histone deacetylase
The invention relates to a compound represented by the following formula (I): and pharmaceutically acceptable salts, stereoisomers, enantiomers, prodrugs and solvates thereof. The compounds are useful as an agent for enhancing the neurite outgrowth and preventing or treating of diseases associated with HDAC in particular, tumor or cell proliferative diseases. In particular, the compounds of the invention can be used as an agent for anti-cancer, anti-diabetic, and anti-neurodegenerative diseases such as Alzheimer's disease, Huntington's disease, Spinocerebellar Ataxias (SCA), and human spinal muscular atrophy (SMA). |
| US08318800B2 |
Solid pharmaceutical compositions containing benzofuran derivatives
The present invention relates to a solid pharmaceutical composition for oral administration characterized in that it comprises a benzofuran derivative with antiarrhythmic activity, or one of the pharmaceutically acceptable salts thereof, as an active principle, and a pharmaceutically acceptable nonionic hydrophilic surfactant optionally in combination with one or more pharmaceutical excipients. |
| US08318797B2 |
Composition and methods for the protection of hair from treated pool water
Compositions for treating hair are disclosed. Methods of making and using compositions for treating hair are also disclosed. |
| US08318795B2 |
Antioxidant polymers containing [1,2]-dithiolane moieties and uses thereof
The present invention describes polymers containing 1,2-dithiolanes capable of acting as scavengers of free radicals, metals and reactive oxygen species. Also described are methods of synthesizing the antioxidant 1,2-dithiolane derivatives and polymerization thereof to produce biodegradable antioxidant polymers. The antioxidant polymers of the present invention may be used to treat diseases or conditions caused by oxidative stress and other free radical mediated conditions. The antioxidant polymers may also be used for the preparation of antioxidant particulate delivery devices of therapeutic agents. |
| US08318791B2 |
Substituted imidazole derivatives
The present invention relates to new substituted imidazole compounds and pharmaceutically acceptable salts, esters or prodrugs thereof, compositions of the new compounds together with pharmaceutically acceptable carriers, and uses of the new compounds. The compounds of the invention have the following general formula: |
| US08318789B2 |
Co-crystals of propiconazole
The present invention relates to co-crystals of propiconazole and a co-crystal forming compound. |
| US08318787B2 |
Prodrugs of (3,5-bis(4-fluorophenyl)tetrahydro-1H-oxazolo[3,4-C]oxazol-7A-yl)methanol and derivatives thereof
A prodrug that has a prodrug moiety that degrades into a compound having the general Formula I with R3 being an alcoholic moiety can be useful in therapies for neurodegenerative diseases as well as cancer. Accordingly, the prodrug compounds can have a structure of Formula I, analogs thereof, derivatives thereof, or salts thereof, wherein: A and B are sulfur or oxygen; R1 and R2, in para, meta, or ortho position, are independently halogen, alkyl, alkoxy, haloalkyl, where R1 and R2 independently are straight chain, branched, substituted or unsubstituted; and R3 is a prodrug moiety. As examples, the prodrug can have a structure of any of Formulas I-V, which as shown in the specification. |
| US08318786B2 |
Plant pathogen resistance
Azelaic acid or its derivatives or analogs induce a robust and a speedier defense response against pathogens in plants. Azelaic acid treatment alone does not induce many of the known defense-related genes but activates a plant's defense signaling upon pathogen exposure. |
| US08318780B2 |
Methods of administering pirfenidone therapy
The present invention relates to methods involving avoiding adverse drug interactions with fluvoxamine and pirfenidone or other moderate to strong inhibitors of CYP enzymes. |
| US08318778B2 |
Urea glucokinase activators
This application relates to novel urea glucokinase activators and use of the compounds of the invention for preparation of a medicament for the treatment of various diseases, e.g. for the treatment of type 2 diabetes. Further encompassed is a pharmaceutical composition comprising a compound according to the invention and a process for preparing such. |
| US08318776B2 |
Pyridine compound, pesticidal composition and method of controlling pests
A pyridine compound represented by the following general formula (1); the pyridine compound in which R1 is a C1-C3 fluoroalkyl group or a C1-C3 fluoroalkoxy group; the pyridine compound in which R2 is a hydrogen atom; the pyridine compound in which R2 is a group represented by Q1; a pesticidal composition containing the pyridine compound as an active ingredient; and a method of controlling a pest including applying an effective amount of the pyridine compound to the pest or a place where the pest inhabits, are provided. |
| US08318774B2 |
Compounds involving mGluR5 receptor regulation and methods of making the compounds
3-((Thiazol-2-yl)amino)propylproiolamide compounds of the formula I: wherein the variables are as defined herein, are useful to prevent or treat a disease or disorder involving mGluR5 receptor regulation. Also disclosed are pharmaceutical compositions containing the compounds and methods of making the compounds. |
| US08318773B2 |
Isoindoline compounds and methods of their use
Provided herein are isoindoline compounds, pharmaceutical compositions comprising one or more of such compounds, and methods of their use for treating, preventing, or managing various diseases. |
| US08318771B2 |
Method of treatment of nephrogenic diabetes insipidus
Nephrogenic diabetes insipidus is treated with statins. |
| US08318764B2 |
Macrocyclic inhibitors of JAK
The present invention relates to the use of novel macrocyclic compounds of Formula I, wherein the variables Q, Q1, Q2, Q3, and Q4 are defined as described herein, which inhibit JAK and are useful for the treatment of auto-immune and inflammatory diseases. |
| US08318761B2 |
Substituted arylsulfonamides as antiviral agents
The invention relates to substituted arylsulfonamides of formula (I) and methods for their preparation as well as their use for the production of medicaments for the treatment and/or prophylaxis of diseases, especially for use as antiviral agents, particularly against cytomegaloviruses. |
| US08318757B2 |
Substituted isoxazoline compound and pest control agent
There is provided a novel pest control agent, particularly an insecticide or miticide. A substituted isoxazoline compound of General Formula (1): where A1, A2 and A3 independently are CH or N, etc., X1, X2 and X3 are independently are H, a halogen atom, etc., Y1 is H, etc., R1 is —C(O)R1a, —C(S)R1a, R1a is —C(R9)(R9a)—S(O)rR10, —C(R9)(R9a)—S(O)t(R10)═NR11, etc., R2 is H, etc., R3 is CF3, CClF2, etc., R4 is H, etc., R9 is H, etc., R9a is H, etc., R10 is C1-2 alkyl, etc., R11 is H, etc., r is an integer of 0-2, t is an integer of 0 or 1; and a pest control agent comprising the compound or the salt thereof. |
| US08318756B2 |
Methods for administering DPD inhibitors in combination with 5-FU and 5-FU prodrugs
Methods for improved administration and dosing of DPD inhibitors in combination with 5-FU and/or 5-FU prodrugs are provided, comprising first administering to a patient in need thereof a DPD inhibitor that substantially eliminates activity of the enzyme and thereafter administering 5-FU or a 5-FU prodrug, wherein the level of 5-FU or 5-FU prodrug is in substantial excess of DPD inhibitor in the patient. |
| US08318755B2 |
Inhibitors of SYK and JAK protein kinases
The present invention is directed to compounds of formula I-V and tautomers thereof or pharmaceutically acceptable salts, esters, and prodrugs thereof which are inhibitors of syk kinase. The present invention is also directed to intermediates used in making such compounds, the preparation of such a compound, pharmaceutical compositions containing such a compound, methods of inhibition syk kinase activity, methods of inhibition the platelet aggregation, and methods to prevent or treat a number of conditions mediated at least in part by syk kinase activity, such as undesired thrombosis and Non Hodgkin's Lymphoma. |
| US08318753B2 |
Farnesyl transferase inhibiting 1,2-annelated quinoline enantiomer
(−)-5-(3-Chlorophenyl)-α-(4-chlorophenyl)-α-(1-methyl-1H-imidazol-5-yl)tetrazolo-[1,5-a]quinazoline-7-methanamine and its pharmaceutically acceptable acid addition salts, and the use of such compounds in medicine especially for the treatment of cancer. |
| US08318752B2 |
4-(3-chloro-2-fluoroanilino)-7-methoxy-6-{[1-(N-methylcarbamoyl-methyl)piperidin-4-yl]oxy}quinazoline, its pharmaceutically acceptable salts, and pharmaceutical compositions comprising the same
The invention concerns quinazoline derivatives of Formula (I): wherein each of R1, X1, R2, R3, R5, n and m have any of the meanings defined in the description; processes for their preparation, pharmaceutical compositions containing them and their use in the manufacture of a medicament for use as an antiproliferative agent in the prevention or treatment of tumors which are sensitive to inhibition of EGF and erbB receptor tyrosine kinases. |
| US08318749B2 |
Quinazoline derivatives as NK3 receptor antagonists
The present invention relates to a compounds of formula I wherein R1, R2, R3, R4, R5, and n are as defined herein and to a pharmaceutically active salt, a racemic mixture, an enantiomer, an optical isomer or a tautomeric form thereof. The present compounds are high potential NK-3 receptor antagonists for the treatment of depression, pain, psychosis, Parkinson's disease, schizophrenia, anxiety and attention deficit hyperactivity disorder (ADHD). |
| US08318748B2 |
Cathepsin cysteine protease inhibitors
This invention relates to a novel class of compounds which are cysteine protease inhibitors, including but not limited to, inhibitors of cathepsins K, L, S and B. These compounds are useful for treating diseases in which inhibition of bone resorption is indicated, such as osteoporosis. |
| US08318743B2 |
Medicament for the enhancement of cognitive function and neuroprotection
The invention relates the use of 4-chloro-5-{2-[4-(6-fluoro-1,2-benz[d]isoxazole-3-yl)piperidin-1-yl]ethyl-amino}-2-methyl-3-(2H)pyridazinone of the Formula (I) or pharmaceutically acceptable salts thereof for the preparation of medicaments suitable for the improvement of cognitive function or obtaining neuroprotective effect. The medicaments containing 4-chloro-5-{2-[4-(6-fluoro-1,2-benz[d]isoxazol-3-yl)piperidin-1-yl]ethyl-amino}-2-methyl-3-(2H)pyridazinone of the Formula (I) or therapeutically acceptable salt thereof can be used for the treatment or prevention of neuronal death, mental decline, sclerosis multiplex, Creuzfeld-Jacobs disease, Huntington-syndrome, amyotrophic lateral sclerosis, Parkinson-disease, memory disturbance, loss of memory, amnesia, stroke or for the improvement of memory function or learning ability. |
| US08318742B2 |
Bicyclic benzamides of 3- or 4-substituted 4-(aminomethyl)-piperidine derivatives
The present invention of compounds of formula (I) a stereochemically isomeric form thereof, an N-oxide form thereof or a pharmaceutically acceptable acid addition salt thereof. Processes for preparing said products, formulations comprising said products and their use as a medicine are disclosed, in particular for treating conditions which are related to impairment of gastric emptying. |
| US08318736B2 |
HIV inhibiting 5,6-substituted pyrimidines
HIV replication inhibitors of formula wherein R1, R2, R3, R4, R5, R6, R7, R8, R9 and X have specific definitions, and pharmaceutical compositions containing these compounds as active ingredient and processes for preparing said compounds and compositions. |
| US08318733B2 |
Modulators of ATP-binding cassette transporters
Compounds of the present invention, and pharmaceutically acceptable compositions thereof, are useful as modulators of ATP-Binding Cassette (“ABC”) transporters or fragments thereof, including Cystic Fibrosis Transmembrane Conductance Regulator (“CFTR”). The present invention also relates to methods of treating ABC transporter mediated diseases using compounds of the present invention. |
| US08318732B2 |
Compounds having antiviral properties
The present invention provides a compound of formula (I) or a pharmaceutically acceptable derivative, salt or prodrug thereof. The present invention further provides a method of treatment or prophylaxis of a viral infection in a subject comprising administering to said subject an effective amount of a compound of formula (I) or a pharmaceutically acceptable derivative, salt or prodrug thereof. Pharmaceutical compositions comprising a compound of formula (I) are also provided. |
| US08318731B2 |
Pyrrolopyrimidines
The present invention relates to compounds or pharmaceutically-acceptable salts thereof, processes for preparing them, pharmaceutical compositions containing them and their use in therapy. The invention particularly relates to compounds that are polo-like kinase (PLKs) inhibitors useful for the treatment of disease states mediated by PLK, especially PLK4, in particular such compounds that are useful in the treatment of pathological processes which involve an aberrant cellular proliferation, such as tumor growth, rheumatoid arthritis, restenosis and atherosclerosis. |
| US08318729B2 |
Phenylacetic acid compound
A compound represented by formula (I), wherein R1 represents a hydrogen atom, etc., R2 and R3 each independently represents a hydrogen atom, optionally oxidized C1-4 alkyl group or optionally protected hydroxyl group, or R2 and R3 taken together represent optionally oxidized C2-5 alkylene group, R4 represents an optionally oxidized C1-6 alkyl group, etc., R5 represents an optionally oxidized C1-6 alkyl group, etc., R6 represents an optionally oxidized C1-6 alkyl group, etc., m represents 0 or an integer from 1 to 3, n represents 0 or an integer from 1 to 4, and i represents 0 or an integer from 1 to 7. |
| US08318728B2 |
Compounds and compositions for treating chemical warfare agent-induced injuries
Compounds and compositions for treating injuries caused by exposure to chemical warfare agents are described herein. |
| US08318725B2 |
Aryl indolyl sulfonamide compounds and their use as 5-HT6 ligands
The present invention relates to novel aryl indolyl sulfonamide compounds of the formula (I), their tautomeric forms, their stereoisomers, their polymorphs, their pharmaceutically acceptable salts, their pharmaceutically acceptable solvates described herein and pharmaceutically acceptable compositions containing them. |
| US08318721B2 |
Topical pharmaceutical composition comprising a cholinergic agent or a calcium channel blocker
A method and composition are provided for the treatment of an anorectal disorder and for controlling the pain associated therewith. The method comprises administering to a subject in need of such treatment therapeutically effective amounts of a calcium channel blocker either alone or together with a nitric oxide donor. Amlodipine, anipamil, barnidipine, benidipine, bepridil, darodipine, diltiazem, efonidipine, felodipine, isradipine, lacidipine, lercanidipine, lidoflazine, manidipine, mepirodipine, nicardipine, nifedipine, niludipine, nilvadipine, nimodipine, nisoldipine, nitrendipine, perhexiline, tiapamil, verapamil and pharmaceutically acceptable salts thereof, are suitable calcium channel blockers. |
| US08318719B2 |
Inhibitors of Bruton's tyrosine kinase
This application discloses 5-phenyl-1H-pyridin-2-one, 6-phenyl-2H-pyridazin-3-one, and 5-phenyl-1H-pyrazin-2-one derivatives according to generic Formulae I-II: wherein, variables Q1, Q2, R, X, Y1, Y2, Y2′, Y3, Y4, Y5, m, and p are defined as described herein, which inhibit Btk. The compounds disclosed herein are useful to modulate the activity of Btk and treat diseases associated with excessive Btk activity. The compounds are further useful to treat inflammatory and auto immune diseases associated with aberrant B-cell proliferation such as rheumatoid arthritis. Also disclosed are compositions containing compounds of Formulae I-II and at least one carrier, diluent or excipient. |
| US08318714B2 |
Liquid ganaxolone formulations and methods for the making and use thereof
In certain embodiments, the invention is directed to composition comprising stable particles comprising ganaxolone, wherein the volume weighted median diameter (D50) of the particles is from about 50 nm to about 500 nm. |
| US08318713B2 |
Potentiation of cancer chemotherapy by 7-(2, 5-dihydro-4-imidazo [1, 2-A] pyridine-3-yl-2,5-Dioxo-1H-pyrrol-3-yl)-9-fluoro-1,2,3,4 tetrahydro-2-(1-piperidinyl-carbonyl)-pyrrolo [3,2,1-jk] [1,4] benzodiazepine
A method for treating gastric cancer, ovarian cancer, non-small cell lung cancer, or colorectal cancer in a patient is described, as well as pharmaceutical compositions comprising 7-(2,5-dihydro-4-imidazo[1,2-a]pyridine-3-yl-2,5-dioxo-IH-pyrrol-3-yl)-9-fluoro-1,2,3,4-tetrahydro-2-(1-piperidinyl-carbonyl)-pyrrolo[3,2,1-jk][1,4]benzodiazepine, useful for the method and a process for preparing said compositions. |
| US08318709B2 |
Combination of azelastine and mometasone for nasal administration
A pharmaceutical product or formulation, which comprises azelastine or a pharmaceutically acceptable salt, solvate or physiologically functional derivative thereof, and a steroid, or a pharmaceutical acceptable salt, solvate or physiologically functional derivative thereof, preferably the product or formulation being in a form suitable for nasal or ocular administration. |
| US08318707B2 |
Administration of (S)-roscovitine for protection against and/or treatment of neurological diseases
The present invention relates to the use of 6-(benzyl-amino)-2(S)-[[1-(hydroxymethyl) propyl]amino]-9-isopropylpurine) or at least one of its pharmaceutical acceptable salts for manufacturing a medication intended for the prevention and/or treatment of neurological diseases, in particular associated with neurological lesions. |
| US08318706B2 |
Substituted tetracycline compounds
The present invention pertains, at least in part, to novel substituted tetracycline compounds. These tetracycline compounds can be used to treat numerous tetracycline compound-responsive states, such as bacterial infections and neoplasms. |
| US08318705B2 |
Nitroso compounds as nitroxyl donors and methods of use thereof
The invention relates to nitroso derivatives including carboxylic acid and phosphoric acid esters of hydroxy nitroso compounds that donate nitroxyl (HNO) under physiological conditions. The compounds and compositions of the invention are useful in treating and/or preventing the onset and/or development of diseases or conditions that are responsive to nitroxyl therapy, including heart failure, ischemia/reperfusion injury and cancer. |
| US08318701B2 |
Phosphonate analogs of HIV inhibitor compounds
The invention is related to phosphorus substituted anti-viral inhibitory compounds, compositions containing such compounds, and therapeutic methods that include the administration of such compounds, as well as to processes and intermediates useful for preparing such compounds. |
| US08318697B2 |
Prophylactic and therapeutic treatment of infectious and other diseases with mono- and disaccharide-based compounds
Methods and compositions for treating or ameliorating diseases and other conditions, such as infectious diseases, autoimmune diseases and allergies are provided. The methods employ mono- and disaccharide-based compounds for selectively stimulating immune responses in animals and plants. |
| US08318695B2 |
Tunably crosslinked polysaccharide compositions
The present invention generally relates to novel biocompatible crosslinked polysaccharide gel compositions, methods of their manufacture and use, and the novel crosslinkers used to make them. In one aspect of the invention, a novel polyethylene glycol crosslinking agent is described for crosslinking hyaluronic acid. In another aspect of the invention, novel crosslinking agents comprising more than two functional groups are described. These multifunctional crosslinking agents can be used on their own to crosslink hyaluronic acid, or they may be combined with bifunctional crosslinking agents in varying ratios to make hyaluronic acid of tunable mechanical strength and hardness. The present invention also discloses novel hyaluronic acid compositions that have been coated with polyethylene glycol and methods of their use. |
| US08318694B2 |
Process for producing sugar chain derivative, structure analysis method, and sugar chain derivative
A process for preparing an oligosaccharide derivative from an oligosaccharide mixture, the process being characterized in that the process comprises the steps of (a) introducing a lipophilic group into oligosaccharides of the mixture to obtain a mixture of oligosaccharide derivatives, and (b) treating the oligosaccharide derivative mixture by serotonin affinity column chromatography. |
| US08318684B2 |
Antibiotics, bispolides A1, A2, and A3 as well as bispolides B1, B2a, B2b and B3 and processes for producing said antibiotics
Seven novel antibiotic substances can be produced by cultivation of a microbial strain which has been isolated from a soil sample and which is designated as Microbispora sp. A 34030 (deposited under an access number FERM BP-10505 in terms of Budapest Treaty). These seven antibiotic substances are named as bispolide A1, bispolide A2, bispolide A3, bispolide B1, bispolide B2a, bispolide B2b and bispolide B3, respectively. These bispolides are each novel compounds which have a chemical structure as collectively represented by the general formula (III) shown below: These bispolides have each a high antibacterial activity against a variety of bacteria, particularly Gram-positive bacteria and their antibiotic-resistant strains, and hence these bispolides each are effective and useful for therapeutically treating bacterial infections of Gram-positive bacteria in humans and animals. |
| US08318682B2 |
1′substituted carba-nucleoside analogs for antiviral treatment
Provided are pyrrolo[1,2-f][1,2,4]triazinyl, imidazo[1,5-f][1,2,4]triazinyl, imidazo[1,2-f][1,2,4]triazinyl, and [1,2,4]triazolo[4,3-f][1,2,4]triazinyl nucleosides, nucleoside phosphates and prodrugs thereof, wherein the 1′ position of the nucleoside sugar is substituted with a cyano group. The compounds, compositions, and methods provided are useful for the treatment of Flaviviridae virus infections, particularly hepatitis C infections. |
| US08318675B2 |
Crustacean androgenic gland hormone, associated peptides, and use thereof
The invention relates to a crustacean androgenic gland hormone. More specifically, described are an androgenic gland hormone and associated peptides derived from Penaeus monodon, and their use to influence the sex ratio in prawn and shrimp cultures, and to set up monosex cultures. It is also related to the use of the hormone and associated peptides, associated gene or fragments thereof in sex determination. |
| US08318670B2 |
Antigens targeted by pathogenic AI4 T cells in type 1 diabetes and uses thereof
Provided are oligopeptide antigens to AI4-like T cells, and mouse proteins comprising those antigens. The oligopeptide antigens comprise the amino acid sequence XX(I/D/F/L)ENY(I/L)(E/W/Y)(L/M) or VMLENYTHL. Additionally provided are methods for treating a mammal having or at risk for type 1 diabetes using these antigens, or compounds which reduce or eliminate expression of these antigens. Kits comprising these antigens, and methods for determining whether a mammal is at risk for or has type 1 diabetes are also provided. |
| US08318669B2 |
Method of regulating glucose metabolism, and reagents related thereto
The present invention provides methods for modification and regulation of glucagon-like peptide 1 (GLP-1) metabolism by administering therapeutically effective amounts of an inhibitor of dipeptidylpeptidase IV (DPIV) or a pharmaceutically acceptable salt thereof, where the inhibitor has a Ki for inhibition of DPIV of 10 nM or less; and the inhibitor is administered in an amount sufficient to inhibit DPIV proteolysis of GLP-1 but not sufficient to suppress the immune system of the animal. |
| US08318667B2 |
Glucagon receptor antagonist compounds, compositions containing such compounds and methods of use
Glucagon receptor antagonist compounds are disclosed. The compounds are useful for treating type (2) diabetes and related conditions. Pharmaceutical compositions and methods of treatment are also included. |
| US08318666B2 |
Use of leptin to treat metabolic abnormalities associated with lipoatrophy
Leptin, leptin analogs, and leptin derivatives are used to treat patients with lipoatrophy. Leptin is effective against conditions of lipoatrophy for both genetic and acquired forms of the disease. A therapeutically effective amount of leptin can be administered in a variety of ways, including subcutaneously and using gene therapy methods. Methods of the present invention contemplate administration of leptin, leptin analogs, and leptin derivatives to patients having a leptin level of approximately 4 ng/ml or less before treatment. |
| US08318663B2 |
Methods of treating diabetes and/or obesity using an enteroendocrine peptide secretion enhancing agent
Provided herein are methods and compositions for treating metabolic diseases and conditions associated with metabolic diseases. |
| US08318662B2 |
Protein increasing cell infectivity of herpes simplex virus and use thereof
Provided are an isolated protein derived from an N-terminal of HveA/HVEM and having activity of increasing the cell infectivity of herpes simplex virus (HSV) and use thereof. |
| US08318660B2 |
Method of treating a disease by administering caspase-8
The invention relates to caspases and to extracellular use of caspases for regulating cell functions. |
| US08318652B2 |
Colored speckles comprising a porous carrier and a releasing agent layer
This invention relates to non-bleeding and quick color releasing colored speckles for use in granular laundry detergents and other consumer products. The speckles are comprised of a porous carrier, a releasing agent, and a coloring agent. |
| US08318644B2 |
Lubricating oil
The invention provides a lube oil which exhibits low vapor pressure despite having low viscosity, is non-flammable, exhibits excellent heat resistance, has tribological characteristics equivalent to those of conventional hydrocarbon-based lube oils, and can be used for a long time under very severe conditions such as high temperature and vacuum.The lube oil contains, as a base oil, an ionic liquid formed of a cation and an anion and having an ion concentration of 1 mol/dm3 or more. |
| US08318643B2 |
Trunk piston engine lubricating oil compositions
A trunk piston engine lubricating oil composition is disclosed comprising (a) a major amount of a base stock containing at least 90% by weight saturated hydrocarbons; and (b) a base stock selected from the group consisting of (i) an ester base stock wherein the ester base stock is present in an amount greater than 10% by weight and no greater than about 45% by weight, based on the total weight of the lubricating oil composition, (ii) an alkylated aromatic base stock, (iii) a base stock having an aromatic content of at least about 50% by weight wherein the base stock having an aromatic content of at least about 50% by weight is not an aromatic extract, and mixtures thereof. |
| US08318641B2 |
Systems and methods for the detection of biomarkers
Systems and methods for the detection of biomarkers. In at least one embodiment of a microarray system of the present disclosure, the microarray system comprises a microarray product comprising at least 100 diagnostic markers/cm2, a microarray identifier, and a stabilizing agent, a control microarray product comprising a first specific binding pair member that binds to a first detectable label, and a processor for providing information regarding the identification and concentration of markers on the microarray based on the identity of the array provided by the microarray identifier. |
| US08318640B2 |
Methods for selective targeting
A selective targeting method is disclosed comprising contacting a library of ligands, particularly a peptide library, with an anti-target to allow the ligands to bind to the anti-target; separating the non-binding ligands from the anti-target bound ligands, contacting the non-binding anti-target ligands with a target allowing the unbound ligands to bind with the target to form a target-bound ligand complex; separating the target-bound ligand complex from ligands which do not bind to the target, and identifying the target-bound ligands on the target-bound ligand complex wherein the target-bound ligands have a KD in the range of about 10−7 to 10−10 M. Additionally claimed are the ligands identified according to the method. |
| US08318639B2 |
Superconducting composite, preliminary product of superconducting composite and method for producing same
Disclosed herein are superconducting composites, and preliminary products therefor, having a core comprising a superconducting phase, a first casing surrounding the core, and having an inner area abutting the core and having a first magnesium concentration and an outer area having a second magnesium concentration greater than the first magnesium concentration, wherein the second magnesium concentration is, on average, between 5 and 40 atomic percent. Desirably, the superconducting phase comprises a MgB2 phase. This arrangement allows for methods for producing the composites that reduce or eliminate subjecting the superconducting phase to mechanical stresses. |
| US08318638B2 |
Plant activator
An object of the present invention is to determine novel means of activating plants; more particularly, means of controlling plant growth, such as means of promoting growth, means of controlling dormancy, means of imparting tolerance against stress for plants (dryness, high or low temperatures, osmotic pressure, etc.), and means of preventing aging. The present inventors have found that the above object can be achieved by providing plant activators containing, as an active ingredient, C4-C24 ketol fatty acids, in particular, 9-hydroxy-10-oxo-12(Z),15(Z)-octadecadienoic acid. |
| US08318637B2 |
Herbicide/azole combination
Herbicide/azole combination comprising components (A) and (B) having improved effects, where (A)is one or more herbicidally active compounds from the group of the ALS inhibitors, and (B)is one or more agrochemically active azole compounds, preferably from the group of the triazoles, pyrazoles and triazolinethiones. |
| US08318635B2 |
Phytotoxicity controlling agent for upland farming and phytotoxicity controlling method using the same
It is intended to provide a phytotoxicity controlling agent usable as a herbicide for upland farming, which exerts a sufficient herbicidal effect on weeds growing together with upland crops, for example, wheat, rye, barley, oat, corn, sorghum, cotton, soybean, adzuki bean, oilseed rape, beet, upland rice and so on but causes no phytotoxic phenomenon (for example, growth inhibition, growth suppression, tiller inhibition or yellowing) in cultivated plants, comprising a nuclear-substituted benzoic acid represented by the following general formula: wherein R1 represents linear or branched C4-15 alkyl; a salt thereof or an alkyl ester thereof. |
| US08318631B2 |
Process for preparing a catalyst consisting of a support body and a catalytically active composition applied on the surface of the support body
A process for preparing a coated catalyst in which a finely divided mixture of a multielement oxide comprising the elements Mo and V and a molybdenum oxide or a molybdenum oxide former is applied to the surface of a support body as an active composition. |
| US08318628B2 |
Hydrotreatment catalyst, method for production and use thereof
The invention relates to a catalyst for hydroconversion of hydrocarbons, comprising a support made from at least one refractory oxide, at least one group VIII metal and at least one group VIB metal, characterized in further comprising at least one organic compound with at least two thiol functions separated by at least one oxygenated group of formula (I): HS—CxHyOz—SH (I), where x=1 to 20, preferably 2 to 9 and for example x=6, y=2 to 60, preferably 4 to 12 and z=1 to 10, preferably 1 to 6. The invention further relates to a method for preparation, a method for activation of said catalyst and use of the catalyst for the hydrotreatment and/or hydrocracking of hydrocarbons. |
| US08318627B2 |
Process for preparation of a catalyst carrier
This invention relates to catalyst carriers to be used as supports for metal and metal oxide catalyst components of use in a variety of chemical reactions. More specifically, the invention provides a process of formulating a low surface area alpha alumina carrier that is suitable as a support for silver and the use of such catalyst in chemical reactions, especially the epoxidation of ethylene to ethylene oxide. A precursor for a catalyst support comprises an admixture of an alpha alumina and/or a transition alumina; a binder; and either a solid blowing agent which expands, or propels a gas upon the application of sufficient heat, and optionally contains talc and/or water soluble titanium compound. |
| US08318624B2 |
Dielectric ceramic and laminated capacitor
A dielectric ceramic containing a BaTiO3 based material as its main constituent, and, as accessory constituents, a rare-earth element R(R is at least one selected from Nd, Eu, Gd, Tb, Dy, Ho, Er, Yb, and Y), M (M is at least one selected from Mg, Mn, Ni, Co, Cu, Al, Mo, W, and V), SiO2, and CaO. Among crystal grains included in this dielectric ceramic, the ratio of the number of crystal grains 11 in which Si is present in solid solution is 5% or more. |
| US08318621B2 |
Silico-sodo-calcic glass sheet
The invention relates to a glass sheet, the composition of which is of the soda-lime-silica type and comprises the following constituents in contents varying within the weight limits defined below: Fe2O3 (total iron) 0 to 0.02%; and WO3 0.1 to 2%. |
| US08318619B2 |
Transparent, colorless low-titania β-quartz glass-ceramic material
The invention mainly relates to a transparent, essentially colorless/?β-quartz glass-ceramic material, the composition of which is free of As2O3 and of Sb2O3 and contains a specific combination of three nucleating agents: TiO2, ZrO2 and SnO2; TiO2 being present in low quantity. |
| US08318616B2 |
Salt water swellable compositions and articles
The compositions, articles and methods described herein remain intact for sealing between and around structures that contact salt water. The compositions include: (i) a partially cross-linked polyacrylamide/partially neutralized polyacrylic acid copolymer; (ii) a smectite clay; (iii) an elastomer, e.g., butyl rubber; (iv) a polyolefin polymer or copolymer; and (v) a cationic flocculant, the compositions have exceptional and unexpected free swell and cohesiveness when in contact with high conductivity water or multivalent ion-containing-contaminated water. The articles of manufacture described herein all include a combination of (i) a partially cross-linked acrylamide/acrylate/acrylic acid copolymer; (ii) a smectite clay; (iii) an elastomer, e.g., butyl rubber; (iv) polyisobutene or polyisopropene; and (v) a cationic flocculent, and are used for waterproofing against high conductivity salt-containing water preferably when used in putty-like or paste-like consistency to fill areas between and around structures, e.g., to surround a pipe inserted in a concrete wall, or to seal between two concrete sections. |
| US08318615B1 |
Launderable, leak-proof, breathable fabric and articles made therefrom
A launderable and reusable, leak-proof, breathable fabric and, more specifically, a composite fabric comprised of a liquid absorptive layer and a liquid impervious but vapor permeable layer. Such fabric is useful in drawing fluids, such as bodily fluids, away from a source, such as the body, and retaining them within the absorptive layer while evaporation thereof takes place though the vapor permeable layer. This material consists of two juxtaposed layers. The inner layer has the characteristic of being liquid permeable so as to allow the body fluids to flow into it and be absorbed. The outer layer has the characteristic of being liquid impermeable but air or vapor permeable, so that the liquid absorbed in the inner layer does not strike through the outer layer. |
| US08318612B2 |
Methods for improving the quality of group III-nitride materials and structures produced by the methods
The invention provides methods which can be applied during the epitaxial growth of two or more layers of Group III-nitride semiconductor materials so that the qualities of successive layer are successively improved. In preferred embodiments, surface defects interact with a protective layer of a protective material to form amorphous complex regions capable of preventing the further propagation of defects and dislocations. The invention also includes semiconductor structures fabricated by these methods. |
| US08318611B2 |
Combinatorial plasma enhanced deposition techniques
Combinatorial plasma enhanced deposition techniques are described, including designating multiple regions of a substrate, providing a precursor to at least a first region of the multiple regions, and providing a plasma to the first region to deposit a first material on the first region formed using the first precursor, wherein the first material is different from a second material formed on a second region of the substrate. |
| US08318609B2 |
Method of depositing materials on a non-planar surface
A carrier for effectuating semiconductor processing on a non-planar substrate is disclosed. The carrier is configured for holding at least one non-planar substrate throughout a semiconductor processing step and concurrently rotating non-planar substrates as they travel down a translational path of a processing chamber. As the non-planar substrates simultaneously rotate and translate down a processing chamber, the rotation exposes the whole or any desired portion of the surface area of the non-planar substrates to the deposition process, allowing for uniform deposition as desired. Alternatively, any predetermined pattern is able to be exposed on the surface of the non-planar substrates. Such a carrier effectuates manufacture of non-planar semiconductor devices, including, but not limited to, non-planar light emitting diodes, non-planar photovoltaic cells, and the like. |
| US08318608B2 |
Method of fabricating a nonvolatile charge trap memory device
A method for fabricating a nonvolatile charge trap memory device is described. The method includes providing a substrate having a charge-trapping layer disposed thereon. A portion of the charge-trapping layer is then oxidized to form a blocking dielectric layer above the charge-trapping layer by exposing the charge-trapping layer to a radical oxidation process. |
| US08318604B2 |
Substrate comprising a nanometer-scale projection array
A method for forming a substrate comprising nanometer-scale pillars or cones that project from the surface of the substrate is disclosed. The method enables control over physical characteristics of the projections including diameter, sidewall angle, and tip shape. The method further enables control over the arrangement of the projections including characteristics such as center-to-center spacing and separation distance. |
| US08318602B2 |
Nonvolatile semiconductor storage apparatus and method for manufacturing the same
According to an aspect of the present invention, there is provided a nonvolatile semiconductor storage apparatus including: a substrate; a columnar semiconductor disposed perpendicular to the substrate; a charge storage laminated film disposed around the columnar semiconductor; a first conductor layer that is in contact with the charge storage laminated film and that has a first end portion having a first end face; a second conductor layer that is in contact with the charge storage laminated film, that is separated from the first conductor layer and that has a second end portion having a second end face; a first contact plug disposed on the first end face; and a second contact plug disposed on the second end face. |
| US08318599B2 |
Resin layer formation method and semiconductor device fabrication method
The resin layer formation method comprises the step of forming on a substrate 10 a resin layer 34 for containing a substance for decreasing the thermal expansion coefficient to thereby forming a resin layer 34 having said substance localized in the side thereof nearer to the substrate 10; and the step of cutting the surface of the resin layer 34 with a cutting tool 40 to planarize the surface of the resin layer 34. The resin layer 34 as said substance for decreasing the thermal expansion coefficient localized in the side thereof nearer to the substrate 10, and the surface of the resin layer 34 is cut to planarize the surface of the resin layer 34, whereby the extreme abrasion and breakage of the cutting tool 40 by said substance for decreasing the thermal expansion coefficient can be prevented. |
| US08318595B2 |
Self-assembled electrical contacts
Self-assembling microscale electrical and mechanical connections includes a part binding site and a part electrical binding site; and a template binding site comprising a template electrical conductor layer; a metallization layer on the template electrical conductor layer; a bump structure comprising a solder alloy positioned on the metallization layer, wherein the solder alloy is liquefied to allow the bump structure to self-assemble and align with the part electrical binding site using capillary forces, and wherein the solder alloy only liquefies at a temperature above that at which the self-assembly and alignment is performed; and a fluid on the template electrical conductor layer, wherein the fluid comprises a melting point lower than that of the solder alloy, wherein the fluid binds with the part binding site. |
| US08318594B2 |
Method for fabricating nitride-based semiconductor device having electrode on m-plane
A nitride-based semiconductor light-emitting device 100 includes: a GaN substrate 10 with an m-plane surface 12; a semiconductor multilayer structure 20 provided on the m-plane surface 12 of the GaN substrate 10; and an electrode 30 provided on the semiconductor multilayer structure 20. The electrode 30 includes an Mg layer 32 and an Ag layer 34 provided on the Mg layer 32. The Mg layer 32 is in contact with a surface of a p-type semiconductor region of the semiconductor multilayer structure 20. |
| US08318593B2 |
Method for electron beam induced deposition of conductive material
The invention relates to a method for electron beam induced deposition of electrically conductive material from a metal carbonyl with the method steps of providing at least one electron beam at a position of a substrate, storing at least one metal carbonyl at a first temperature, and heating the at least one metal carbonyl to at least one second temperature prior to the provision at the position at which the at least one electron beam impacts on the substrate. |
| US08318592B2 |
Gate patterns of nonvolatile memory device and method of forming the same
A method of forming gate patterns of a nonvolatile memory device comprises forming stack patterns each having an insulating layer and a conductive layer stacked over a semiconductor substrate, and forming an anti-oxidation layer on sidewalls of the insulating layer by selectively nitrifying the insulating layer. |
| US08318590B2 |
Methods and systems for forming thin films
A method and apparatus for the deposition of thin films is described. In embodiments, systems and methods for epitaxial thin film formation are provided, including systems and methods for forming binary compound epitaxial thin films. Methods and systems of embodiments of the invention may be used to form direct bandgap semiconducting binary compound epitaxial thin films, such as, for example, GaN, InN and AlN, and the mixed alloys of these compounds, e.g., (In, Ga)N, (Al, Ga)N, (In, Ga, Al)N. Methods and apparatuses include a multistage deposition process and system which enables rapid repetition of sub-monolayer deposition of thin films. |
| US08318589B2 |
Method for forming transparent conductive oxide
Embodiments disclosed herein generally relate to a process of depositing a transparent conductive oxide layer over a substrate. The transparent oxide layer is sometimes deposited onto a substrate for later use in a solar cell device. The transparent conductive oxide layer may be deposited by a “cold” sputtering process. In other words, during the sputtering process, a plasma is ignited in the processing chamber which naturally heats the substrate. No additional heat is provided to the substrate during deposition such as from the susceptor. After the transparent conductive oxide layer is deposited, the substrate may be annealed and etched, in either order, to texture the transparent conductive oxide layer. In order to tailor the shape of the texturing, different wet etch chemistries may be utilized. The different etch chemistries may be used to shape the surface of the transparent conductive oxide and the etch rate. |
| US08318584B2 |
Oxide-rich liner layer for flowable CVD gapfill
The formation of a gap-filling silicon oxide layer with reduced volume fraction of voids is described. The deposition involves the formation of an oxygen-rich less-flowable liner layer before an oxygen-poor more-flowable gapfill layer. However, the liner layer is deposited within the same chamber as the gapfill layer. The liner layer and the gapfill layer may both be formed by combining a radical component with an unexcited silicon-containing precursor (i.e. not directly excited by application of plasma power). The liner layer has more oxygen content than the gapfill layer and deposits more conformally. The deposition rate of the gapfill layer may be increased by the presence of the liner layer. The gapfill layer may contain silicon, oxygen and nitrogen and be converted at elevated temperature to contain more oxygen and less nitrogen. The presence of the gapfill liner provides a source of oxygen underneath the gapfill layer to augment the gas phase oxygen introduced during the conversion. |
| US08318583B2 |
Method of forming isolation structure of semiconductor device
Provided is a method of forming an isolation structure of a semiconductor device capable of minimizing the number of performing a patterning process and having trenches of various depths. The method includes partially etching the semiconductor substrate using a first patterning process to form first trenches and second trenches having a first depth. The semiconductor substrate has first to third regions. The first trenches are formed in the first region, and the second trenched are formed in the second region. The semiconductor substrate is partially etched using a second patterning process, so that third trenches are formed in the third region, and fourth trenches are formed in the second region. The fourth trenches extend from bottoms of the second trenches. The third trenches have a second depth, and the fourth trenches have a third depth. An isolation layer filling the first to fourth trenches is formed. |
| US08318575B2 |
Compressive polycrystalline silicon film and method of manufacture thereof
In one embodiment a method of forming a compressive polycrystalline semiconductive material layer is disclosed. The method comprises forming a polycrystalline semiconductive seed layer over a substrate and forming a silicon layer by depositing silicon directly on the polycrystalline silicon seed layer under amorphous process conditions at a temperature below 600 C. |
| US08318567B2 |
Thermal treatment equipment and method for heat-treating
The invention provides a method for activating impurity element added to a semiconductor and performing gettering process in shirt time, and a thermal treatment equipment enabling to perform such the heat-treating. The thermal treatment equipment comprises treatment rooms of n pieces (n>2) performing heat-treating, a preparatory heating room, and a cooling room, and heating a substrate using gas heated by heating units of n pieces as a heating source, wherein a gas-supplying unit is connected to a gas charge port of the cooling room, a discharge port of the cooling room is connected to a first gas-heating unit through a heat exchanger, a charge port of an m-th (1≦m≦(n−1)) treatment room is connected to a discharge port of an m-th gas-heating unit, a charge port of an n-th treatment room is connected to a discharge port of an n-th gas-heating unit, a discharge port of the n-th treatment room is connected to the heat exchanger, and discharge port of the heat exchanger is connected to gas charge port of the preparatory heating room. |
| US08318566B2 |
Method to seperate storage regions in the mirror bit device
Devices and methods for isolating adjacent charge accumulation layers in a semiconductor device are disclosed. In one embodiment, a semiconductor device comprises a bit line formed in a semiconductor substrate, a charge accumulation layer formed on the semiconductor substrate, a word line formed on the charge accumulation layer across the bit line, and a channel region formed in the semiconductor substrate below the word line and between the bit line and its adjacent bit line. For the semiconductor device, the charge accumulation layer is formed above the channel region in a widthwise direction of the word line, and a width of the word line is set to be narrower than a distance between an end of the channel region and a central part of the channel region in a lengthwise direction of the word line. |
| US08318565B2 |
High-k dielectric gate structures resistant to oxide growth at the dielectric/silicon substrate interface and methods of manufacture thereof
Methods for fabricating gate electrode/high-k dielectric gate structures having an improved resistance to the growth of silicon dioxide (oxide) at the dielectric/silicon-based substrate interface. In an embodiment, a method of forming a transistor gate structure comprises: incorporating nitrogen into a silicon-based substrate proximate a surface of the substrate; depositing a high-k gate dielectric across the silicon-based substrate; and depositing a gate electrode across the high-k dielectric to form the gate structure. In one embodiment, the gate electrode comprises titanium nitride rich in titanium for inhibiting diffusion of oxygen. |
| US08318561B2 |
Semiconductor device and method of manufacturing the same
According to an aspect of the invention, there is provided a semiconductor device including a plurality of memory cells, comprising a plurality of floating gate electrodes which are formed on a tunnel insulating film formed on a semiconductor substrate and have an upper portion which is narrower in a channel width direction than a lower portion, an interelectrode insulating film formed on the floating gate electrodes, and a control gate electrode which is formed on the interelectrode insulating film formed on the floating gate electrodes and partially buried between the floating gate electrodes opposing each other. |
| US08318560B2 |
Methods of forming integrated circuit devices including a capacitor
Methods of forming a capacitor of an integrated circuit device include forming a lower electrode of the capacitor on an integrated circuit substrate without exposing a contact plug to be coupled to the lower electrode. A supporting conductor is formed coupling the lower electrode to the contact plug after forming the lower electrode. A capacitor dielectric layer is formed on the lower electrode and an upper electrode of the capacitor is formed on the capacitor dielectric layer. |
| US08318559B2 |
Method of fabricating CMOS transistor
The Complementary Metal-Oxide Semiconductor (CMOS) transistor of the present invention includes deep halo doped regions in the substrate. The fabrication of the deep halo doped regions is integrated into the process of making the lightly doped drains or the source/drain doped regions, and therefore no extra mask is required. |
| US08318554B2 |
Method of forming gate insulating film for thin film transistors using plasma oxidation
In forming a thin film transistor, to form a film superior in quality to a film formed by a conventional CVD method and to form a film equal or superior in quality to a film formed by a thermal oxidation method at a temperature which does not affect a substrate. Plasma oxidation or plasma nitridation with a low electron temperature and a high electron density is performed to at least one of a glass substrate, a semiconductor film containing amorphous silicon formed into a predetermined pattern, a gate electrode and a wire pulled from the gate electrode, an insulating film to be a gate insulating film, and a protective film with a temperature of the glass substrate set at a temperature 100° C. or more lower than a strain point of the glass substrate. |
| US08318551B2 |
Semiconductor device and manufacturing method thereof
A gate electrode layer over a substrate; a gate insulating layer over the gate electrode layer; a first source electrode layer and a first drain electrode layer over the gate insulating layer; an oxide semiconductor layer over the gate insulating layer; and a second source electrode layer and a second drain electrode layer over the oxide semiconductor layer. A first part, a second part, and a third part of a bottom surface are in contact with the first source electrode layer, the first drain electrode layer, and the gate insulating layer respectively. A first part and a second part of the top surface are in contact with the second source electrode layer and the second drain electrode layer respectively. The first source electrode layer and the first drain electrode layer are electrically connected to the second source electrode layer and the second drain electrode layer respectively. |
| US08318550B2 |
Multilayer select devices and methods related thereto
Methods of forming and tuning a multilayer select device are provided, along with apparatus and systems which include them. As is broadly disclosed in the specification, one such method can include forming a first region having a first conductivity type; forming a second region having a second conductivity type and located adjacent to the first region; and forming a third region having the first conductivity type and located adjacent to the second region and, such that the first, second and third regions form a structure located between a first electrode and a second electrode, wherein each of the regions have a thickness configured to achieve a current density in a range from about 1×e4 amps/cm2 up to about 1×e8 amps/cm2 when a voltage in a selected voltage range is applied between the first electrode and the second electrode. |
| US08318547B1 |
Integrated circuit package with electrically isolated leads
In one embodiment, an integrated circuit package includes a lead frame with a die paddle and several leads. Portions of the lead frame not having an external electrical connection may be thinned such that they may be encapsulated by an electrically insulating packaging material on the back of the lead frame. Portions of the lead frame having external electrical connections may have a thickness such that they are exposed through the packaging material. The lead frame may be covered by an electrically insulating cover to protect components on the lead frame from erroneous electrical contact or electro-static discharge (ESD) damage. |
| US08318545B2 |
Method of making a mounted gallium nitride device
A method of making a mounted gallium nitride (GaN) device includes obtaining a device structure comprising a silicon layer, a silicon carbide (SiC) layer over the silicon layer, and a GaN layer over the SiC layer. The GaN layer is processed to form an active layer of active devices and interconnect over the GaN layer. After the step of processing the GaN layer, a gold layer is formed on the silicon layer. The device structure is attached to a heat sink structure using the gold layer. The mounted GaN device includes the SiC layer over the polysilicon layer and the GaN layer over the SiC layer. The active layer is over the GaN layer. |
| US08318540B2 |
Method of manufacturing a semiconductor structure
A method of manufacturing a semiconductor structure. One embodiment produces a substrate having at least two semiconductor chips embedded in a molded body. A layer is applied over at least one main surface of the substrate by using a jet printing process. |
| US08318539B2 |
Method of manufacture of integrated circuit packaging system with multi-tier conductive interconnects
A method of manufacture of an integrated circuit packaging system includes: providing a carrier having a planar surface and a cavity therein, a first barrier between the planar surface and a first interconnect, and a second barrier between the cavity and a second interconnect; providing a substrate; mounting an integrated circuit over the substrate; mounting the carrier to the substrate with the first interconnect and the second interconnect attached to the substrate and with the planar surface over the integrated circuit; forming an encapsulation between the substrate and the carrier covering the integrated circuit, the encapsulation having an encapsulation recess under the planar surface and over the integrated circuit; and removing a portion of the carrier to expose the encapsulation, a portion of the first barrier to form a first contact pad, and a portion of the second barrier to form a second contact pad. |
| US08318535B2 |
Method of fabricating a memory card using SiP/SMT hybrid technology
A portable memory card formed from a multi-die assembly, and methods of fabricating same, are disclosed. One such multi-die assembly includes an LGA SiP semiconductor package and a leadframe-based SMT package both affixed to a PCB. The multi-die assembly thus formed may be encased within a standard lid to form a completed portable memory card, such as a standard SD™ card. Test pads on the LGA SiP package, used for testing operation of the package after it is fabricated, may also be used for physically and electrically coupling the LGA SiP package to the PCB. |
| US08318530B2 |
Solar cell buffer layer having varying composition
Described is a continuous electroless deposition method and a system to form a solar cell buffer layer with a varying composition through its thickness are provided. The composition of the buffer layer is varied by varying the composition of a chemical bath deposition solution applied onto an absorber surface on which the buffer layer with varying composition is formed. In one example, the buffer layer with varying composition includes a first section containing CdS, a second section containing CdZnS formed on top of the already deposited CdS, and a third section containing ZnS is formed on the second section All the process steps are applied in a roll-to-roll fashion. In another example, a transparent conductive layer including a first transparent conductive film such as aluminum doped zinc oxide and a second transparent conductive film such as indium tin oxide is deposited over the buffer layer with the varying composition. |
| US08318527B2 |
Manufacturing method of display device
Disclosed is a manufacturing method of a liquid crystal display device where first color filters, second color filters and third color filters which are formed adjacent to each other are provided, the first color filter and the second color filter are patterned in such a manner that one edge portion of the second color filter overlaps an edge portion of the first color filter, and the second color filter and the third color filter are patterned in such a manner that an edge portion of the third color filter overlaps the other edge portion of the second color filter wherein in an exposure step for patterning the second color filter, an exposure quantity in a region corresponding to one edge portion and an exposure quantity in a region corresponding to the other edge portion differ from each other. |
| US08318526B2 |
Manufacturing method for light-sensing structure
A manufacturing method for manufacturing a light-sensing structure is provided. The manufacturing method includes the steps as follows. (a) A circuit layer is formed on an upper surface of a first substrate, wherein the first substrate includes at least one light-sensing device and the circuit layer includes at least one device structure and at least one release feature that is made of metal and is formed on part of the light-sensing device and the device structure. (b) A first light-filtering layer is formed on part of the circuit layer. (c) The release feature is removed by a wet-etching process. |
| US08318520B2 |
Method of microminiaturizing a nano-structure
The present invention provides a “microminiaturizing method of nano-structure” with fabricating process steps as follows:First deposit the material of molecule or atom state on the top-opening of the nano cylindrical pore, which having formed on the substrate, so that the diameter of said top-opening gradually reduce to become a reduced nano-aperture, whose opening diameter is smaller than that of said top-opening;Then, directly pass the deposit material of gas molecule or atom state through said reduced nano-aperture; thereby a nano-structure of nano quantum dot, nano rod or nano ring with smaller nano scale is directly formed on the surface of said substrate, which being laid beneath the bottom of said nano cylindrical pore. |
| US08318519B2 |
Method for handling a semiconductor wafer assembly
Systems and methods for fabricating a light emitting diode include forming a multilayer epitaxial structure above a carrier substrate; depositing at least one metal layer above the multilayer epitaxial structure; removing the carrier substrate. |
| US08318518B2 |
Light emitting device and manufacturing method thereof
A light emitting device including a sapphire layer and a light emitting layer formed on the sapphire layer. The sapphire layer has a polygonal sectional shape whose internal angle is an obtuse angle, such as a regular hexagonal shape. Light emitted from the light emitting layer is totally reflected on one side surface of the sapphire layer and next transmitted through another side surface of the sapphire layer. |
| US08318516B2 |
Method of wafer level purifying light color emitting from a light emitting semiconductor wafer
A method of wafer level purifying light color of a LED semiconsuctor is disclosed. After a LED wafer is fabricated, multi-transparent films formed of first layer and a second layer alternatively until reaching a predetermined number deposited by e-gun deposition with an aid of ion plasma beam. The first layer is formed of an oxide layer and the second layer is formed of a metal oxide layer. The two materials, one has a high index of refraction and the other has a low index of refraction. The total multi-transparent films are about 80 to 120 layer which can narrow wave width about a central wavelength. |
| US08318515B2 |
Growth methodology for light emitting semiconductor devices
A method of manufacturing an optoelectronic light emitting semiconductor device is provided where a Multi-quantum Well (MQW) subassembly is subjected to reduced temperature vapor deposition processing to form one or more of n-type or p-type layers over the MQW subassembly utilizing a plurality of precursors and an indium surfactant. The precursors and the indium surfactant are introduced into the vapor deposition process at respective flow rates with the aid of one or more carrier gases, at least one of which comprises H2. The indium surfactant comprises an amount of indium sufficient to improve crystal quality of the p-type layers formed during the reduced temperature vapor deposition processing and the respective precursor flow rates and the H2 content of the carrier gas are selected to maintain a mole fraction of indium from the indium surfactant to be less than approximately 1% in the n-type or p-type layers. In another embodiment, the reduced temperature vapor deposition processing is executed at a reduced temperature TG, where TG≦TB±5% and TB is the MQW barrier layer growth temperature. Additional embodiments are disclosed and claimed. |
| US08318513B2 |
Method of encapsulating light-emitting diode devices using bent frames
A method for manufacturing light-emitting diode devices. Multiple metal frames are provided. The metal frames are adjacent to each other and are arranged on a same plane. Each metal frame includes a first connection pin and a second connection pin. A light-emitting diode chip is disposed on and electrically connected to each metal frame. The metal frames are respectively bent, enabling the adjacent metal frames to separate from each other. A moldboard formed with a plurality of mold cavities is provided. The bent metal frames are respectively disposed in the mold cavities, locating each light-emitting diode chip in each mold cavity. The mold cavities are respectively filled with package gel. The package gel filled in each mold cavity covers each light-emitting diode chip. The package gel is solidified. The mold cavities are separated from the package gel. The metal frames are separated from each other, forming the light-emitting diode devices. |
| US08318512B2 |
Automated substrate handling and film quality inspection in solar cell processing
The present invention generally provides an apparatus and a method for automatically calibrating the placement of fragile substrates into a substrate carrier. Embodiments of the present invention also provide an apparatus and a method for inspecting the fragile substrates prior to processing to prevent damaged substrates from being further processed or broken in subsequent transferring steps. Embodiments of the invention also generally provide an apparatus and a method for determining the alignment and orientation substrates that are to be delivered into or removed from a substrate carrier. Embodiments of the invention further provide an apparatus and method for accurately positioning the substrate carrier for substrate loading. The substrate carriers are generally used to support a batch of substrates that are to be processed in a batch processing chamber. |
| US08318510B2 |
Method and apparatus for manufacturing magnetoresistive element
A method of manufacturing a magnetoresistive element includes a tunnel barrier forming step. The tunnel barrier forming step comprises a metal layer forming step of forming a metal layer to have a first thickness, a plasma processing step of performing a plasma treatment which exposes the metal layer to a plasma of an inert gas to etch the metal layer to have a second thickness smaller than the first thickness, and an oxidation step of oxidizing the metal layer having undergone the plasma treatment to form a metal oxide which forms a tunnel barrier. |
| US08318509B2 |
Two-phase optical assays for analytes of no intrinsic opitcal contrast
Methods and kits for performing a two-phase optical assay for one or more than one analyte without intrinsic optical contrast in a sample are disclosed. The method requires use of a functionalized microparticle immobilized with two or more than functional components and an additional set of one or more than one functional component. The assay can be performed in one single container and does not need a wash step. |
| US08318507B2 |
Method for the fractionation and separation of particles by step-wise gradient density extraction
A method for the separation of particles of different densities using a step-wise gradient density extraction method as described herein where a sample is suspended in a liquid volume of an extracting medium of specific density and the particles that have a density less than or equal to that of the extracting medium of specific density can be recovered from a horizonatally rotatable hollow disk or a removable receptacle within a horizontally rotatable hollow disk designed for such purposes while the particles that have a density greater than the extracting medium of specific density form a deposit which can be cycled through the extraction process in an iterative fashion by varying the density of the extracting medium allowing the recovery of discrete particles of differing densities from a test sample. |
| US08318501B2 |
Methods for assaying percentage of glycated hemoglobin
The invention provides enzymatic methods for direct determination of percentage of glycated hemoglobin in blood samples without the need of a separated measurement of total hemoglobin content in blood samples. The methods utilizes one or two different types of oxidizing agents which selectively oxidize low-molecular weight reducing substances and high-molecular weight (mainly hemoglobin) reducing substances in blood samples, coupled with enzymatic reactions catalyzed by proteases, fructosyl amino acid oxidase, and peroxidase. The invention provides kits for performing the methods of the invention. |
| US08318498B2 |
Luminescent protein staining
The present invention relates to the use of cyclometalated iridium complexes for detecting poly(amino acids) including peptides, polypeptides, and proteins. Poly(amino acids) are detected in solution, in electrophorectic gels, and on solid supports, including blots. The method of the present invention is rapid, highly sensitive, and extremely facile. |
| US08318495B1 |
Hematopoietic progenitor cell gene transduction
Genetically engineered hematopoietic progenitor cells that carry within them genes of interest, particularly for the expression of physiologically or pharmacologically active proteins. The hematopoietic progenitor cells are transduced in the presence of human mesenchymal stem cells which enhance transduction efficiency. |
| US08318490B2 |
Prelamin A pre peptide as a universal stem cell differentiation signal
Disclosed is the use of prelamin A pre peptide and homologues or analogs thereof for the induction of cell differentiation and tissue or organ growth and repair processes. The invention extends to virtually any cell, including both embryonic and non-embryonic stem cells, such as stem cells that are progenitors for a wide variety of cell and tissue types. Also disclosed is the use of prelamin A pre peptide and prelamin A to determine and establish cell morphology and tissue architecture. Treatment of a variety of diseases and conditions, as well as cosmetic, general health, and anti-aging applications are described. |
| US08318489B2 |
Prostacyclin directed differentiation of cardiomyocytes from human embryonic stem cells
The present invention relates to the induction of differentiation in stem cells to cardiomyocytes and factors such as prostaglandin alone or in combination with other factors including essential minerals selected from the group including transferrin and selenium, small molecules selected from the group including a p38 MAPK inhibitor such as SB203580 and protein growth factors of the FGF, IGF and BMP families such as but not limited to IGF1, FGF2, BMP2, BMP4 and BMP6. and insulin that influence the process of differentiation to cardiomyocytes. Media that is appropriate for the induction of differentiation of cardiomyocytes from stem cells is also provided wherein the media contains these factors. The use of cardiomyocytes and cardiac progenitors produced by the directed differentiation in transplantation and screening for cardiac compounds is also provided. |
| US08318486B2 |
Co-culturing mammalian embryonic stem cells with human foreskin fibroblasts
A cell culture comprising human foreskin cells, the human foreskin cells being capable of maintaining stem cells in an undifferentiated state when co-cultured therewith. |
| US08318481B2 |
High copy number self-replicating plasmids in pseudomonas
Provided herein are improved copy number plasmids, particularly those plasmids capable of replication in a bacterial cell. The improved copy number plasmid contain a deletion, insertion, or substitution in the replication control region, particularly a Pseudomonas-specific replication control region, that results in an increase in plasmid copy number in comparison to a control plasmid. Also provided are host cells containing the improved copy number plasmids, as well as methods of using the improved copy number plasmids for the recombinant production of a protein of interest. Further provided are methods for generating plasmids with improved copy number. The methods disclosed herein involve the reiterative selection of improved copy number plasmids by the growth and selection of plasmids capable of growth under increasing selective pressure, wherein the selective pressure is applied utilizing a selection agent to which the control plasmid confers resistance. |
| US08318479B2 |
Perfused three-dimensional cell/tissue disease models
A system has been constructed that recapitulate the features of a capillary bed through normal human tissue. The system facilitates perfusion of three-dimensional (3D) cell monocultures and heterotypic cell co-cultures at the length scale of the capillary bed. A major feature is that the system can be utilized within a “multiwell plate” format amenable to high-throughput assays compatible with the type of robotics commonly used in pharmaceutical development. The system provides a means to conduct assays for toxicology and metabolism and as a model for human diseases such as hepatic diseases, including hepatitis, exposure-related pathologies, and cancer. Cancer applications include primary liver cancer as well as metastases. The system can also be used as a means of testing gene therapy approaches for treating disease and inborn genetic defects. |
| US08318474B1 |
Engineered yeast cells and uses thereof
The present application provides engineered yeast cells and uses thereof. In specific embodiments, the yeast cells have a mutation in the GAL2 gene. In specific embodiments, the yeast cells can be used for producing a protein or compound of interest. |
| US08318473B2 |
Biofuel production
Methods, enzymes, recombinant microorganism, and microbial systems are provided for converting polysaccharides, such as those derived from biomass, into suitable monosaccharides or oligosaccharides, as well as for converting suitable monosaccharides or oligosaccharides into commodity chemicals, such as biofuels. Commodity chemicals produced by the methods described herein are also provided. Commodity chemical enriched, refinery-produced petroleum products are also provided, as well as methods for producing the same. |
| US08318469B2 |
Thermus brockianus nucleic acid polymerases
The invention provides nucleic acids and polypeptides for nucleic acid polymerases from a thermophilic organism, Thermus brockianus. The invention also provides methods for using these nucleic acids and polypeptides. |
| US08318465B2 |
Process for intergrated utilization of the energy and material contents of hydrolysates
A process for integrated utilization of the energy and material contents of hydrolysates and solids obtained in the enzymatic hydrolysis of renewable raw materials, in which the resulting hydrolysis solution is used as a carbon source in fermentations and the unhydrolysed solids are sent to biogas production. |
| US08318450B2 |
Optically-detectable enzyme substrates and their method of use
The present invention relates to compounds that are substrates for an enzyme, and upon reaction with the enzyme provide a detectable response, such as an optically detectable response. In particular, the compounds have utility in detecting the presence of a β-lactamase in a sample. In addition to the compounds, methods are disclosed for analyzing a sample for the presence of a β-lactmase, for example, as an indicator of expression of a nucleic acid sequence including a sequence coding for a β-lactmase. Kits are disclosed that include the disclosed compounds and additional components, for example, cells, antibodies, a β-lactmase or instructions for using the components in an assay. |
| US08318448B2 |
Diagnosis of candidiasis and candidemia or invasive Candida infection
The use of an antibody to a C. albicans cell wall antigen or to a solubilized phosphopeptidomannan (PPM) fraction of the cell wall of C. albicans, or preferably a combination of an IgG2 antibody to a phosphopeptidomannan (PPM) fraction of the cell wall of C. albicans, and an IgG1 or IgG3 antibody to a C. albicans cell wall antigen in the diagnosis of candidiasis or invasive candidiasis is disclosed. Also diagnostic tests are disclosed. |
| US08318446B2 |
DNA-damage-induced proteolysis
The present application provides methods for identifying compounds for inhibiting DNA damage-induced Htt proteolysis, and methods and compositions for protecting cells from DNA damage-induced cleavage of Htt. |
| US08318444B2 |
Methods and kits for measuring von Willebrand factor
Methods and kits for measuring levels of von Willebrand factor function in a sample without using a platelet aggregation agonist, such as ristocetin, comprising recombinant glycoprotein Ibα having at least two of a G233V, D235Y and M239V mutations and an agent to detect a complex between the recombinant glycoprotein Ibα and von Willebrand factor. |
| US08318437B2 |
USP47 inhibitors and methods to induce apoptosis
The present invention relates to USP47 (ubiquitin specific protease 47) inhibitors and methods for inducing apoptosis or cell death in a target cell. In certain embodiments, the invention relates to methods and kits to screen for related agents that induce apoptosis. Additionally, the invention relates to assays for screening compounds capable of acting as USP47 inhibitors. |
| US08318436B2 |
Use of genetically modified organisms to generate biomass degrading enzymes
The present invention provides a method and compositions for high throughput screening of genetically modified photosynthetic organisms for plasmic state. The present invention provides methods of producing one or more proteins, including biomass degrading enzymes in a plant. Also provided are the methods of producing biomass degradation pathways in alga cells, particularly in the chloroplast. Single enzymes or multiple enzymes may be produced by the methods disclosed. The methods disclosed herein allow for the production of biofuel, including ethanol. |
| US08318429B2 |
Genetic markers of schizophrenia
The invention includes method of determining if a subject has a genetic predisposition to clinically diagnosed schizophrenia (SZ), schizotypal personality disorder (SPD), and/or schizoaffective disorder (SD). |
| US08318426B2 |
Polymorphisms in voltage-gated sodium channel alpha 1-subunit as markers for therapy selection
A method for determining whether a patient in need thereof will respond to chemotherapy by screening a suitable sample isolated from the patient for a pre-selected polymorphism present in the VGSC gene. |
| US08318422B2 |
Antibacterial treatment of osteoarthritis
The present invention relates to use of an antibacterial agent in the manufacture of a medicament for the treatment of osteoarthritis, more particularly for the treatment of a bacterial infection which is responsible for osteoarthritis. Also described are methods for the diagnosis of osteoarthritis through the detection of certain bacteria in an affected joint of a patient with osteoarthritis. |
| US08318420B2 |
Heated assays for influenza
Methods of increasing specific binding, decreasing non-specific binding, and reducing false-positive interaction in solid phase assays for influenza are disclosed. In the methods, the solid phase apparatus (lateral flow solid phase apparatus or capillary flow solid phase apparatus) is subjected to elevated heat subsequent to application of a test sample to the solid phase apparatus. |
| US08318415B2 |
Method of determining transport and/or storage parameters for maintaining viability of an organ
An organ perfusion apparatus and method monitor, sustain and/or restore viability of organs and preserve organs for storage and/or transport. Other apparatus include an organ transporter, an organ cassette and an organ diagnostic device. The method includes perfusing the organ at hypothermic and/or normothermic temperatures, preferably after hypothermic organ flushing for organ transport and/or storage. The method can be practiced with prior or subsequent static or perfusion hypothermic exposure of the organ. Organ viability is restored by restoring high energy nucleotide (e.g., ATP) levels by perfusing the organ with a medical fluid, such as an oxygenated cross-linked hemoglobin-based bicarbonate medical fluid, at normothermic temperatures. In perfusion, organ perfusion pressure is preferably controlled in response to a sensor disposed in an end of tubing placed in the organ, by a pneumatically pressurized medical fluid reservoir, providing perfusion pressure fine tuning, overpressurization prevention and emergency flow cut-off. In the hypothermic mode, the organ is perfused with a medical fluid, preferably a simple crystalloid solution containing antioxidants, intermittently or in slow continuous flow. The medical fluid may be fed into the organ from an intermediary tank having a low pressure head to avoid organ overpressurization. Preventing overpressurization prevents or reduces damage to vascular endothelial lining and to organ tissue in general. Viability of the organ may be automatically monitored, preferably by monitoring characteristics of the medical fluid perfusate. The perfusion process can be automatically controlled using a control program. |
| US08318414B2 |
System and method to simulate hemodynamics
A system for hemodynamic simulation comprises a vessel having properties of a blood vessel, a reservoir containing a quantity of fluid, tubing connecting the vessel and reservoir, and at least one pump for circulating the fluid within the system. Fluid can be tissue culture medium or blood analog fluid, and the vessel may include mammalian cells attached to its inside. A drive system, comprising two reciprocating drive shafts that are coupled by a cam, enables the uncoupling of pulsatile flow and pulsatile pressure to provide independent control over wall shear stress and circumferential strain. The shaft drives two pumps that are 180 degrees out-of-phase and are connected upstream and downstream of the vessel, and effect this uncoupling. |
| US08318411B2 |
Method for fabricating an interposer
Method for fabricating an interposer is provided. A substrate is provided having thereon at least a conductive via and at least a flange. The flange is bonded on the substrate and shades a portion of the via. A photoresist layer is formed on the interior surface of the via, on a contact surface of the flange and on an inner surface of the flange opposite to the contact surface. An opening is formed in the photoresist layer to expose a portion of the contact surface of the flange, while the photoresist layer still covers the interior surface of the via and the inner surface of the flange. A plating layer is formed on the exposed contact surface of the flange. The photoresist layer is then removed. |
| US08318409B2 |
Dynamic masking method for micro-truss foam fabrication
A system for fabricating a radiation-cured structure is provided. The system includes a radiation-sensitive material configured to at least one of initiate, polymerize, crosslink and dissociate with exposure to radiation. At least one radiation source is configured to project a radiation beam toward the radiation-sensitive material. A smart glass device is disposed between the radiation-sensitive material and the at least one radiation source. The smart glass device includes at least one switchable layer selectively operable from an active state to an inactive state. The smart glass device is configured to expose the radiation-sensitive material to a desired exposure pattern when in one of the active state and the inactive state. A method for fabricating the radiation-cured structure is also provided. |
| US08318407B2 |
Solution processed thin films and laminates, devices comprising such thin films and laminates, and method for their use and manufacture
Devices having a thin film or laminate structure comprising hafnium and/or zirconium oxy hydroxy compounds, and methods for making such devices, are disclosed. The hafnium and zirconium compounds can be doped, typically with other metals, such as lanthanum. Examples of electronic devices or components that can be made include, without limitation, insulators, transistors and capacitors. A method for patterning a device using the materials as positive or negative resists or as functional device components also is described. For example, a master plate for imprint lithography can be made. An embodiment of a method for making a device having a corrosion barrier also is described. Embodiments of an optical device comprising an optical substrate and coating also are described. Embodiments of a physical ruler also are disclosed, such as for accurately measuring dimensions using an electron microscope. |
| US08318406B2 |
Method for fixing a flexographic plate
A method includes removing the previously imaged area (120) from the flexographic plate (104) to create an opening in the flexographic plate; providing a portion (108) from a flexographic plate built from similar material of the previously imaged flexographic plate; adding adhesive material (116) to the portion or to the opening or to the portion and to the opening; placing the opening within the portion; curing the adhesive material to permanently fix the portion to the flexographic plate; polishing the top (508) of the portion to match to the top surface (504) of the flexographic plate; and imaging the portion. |
| US08318405B2 |
Negative-working imageable elements with overcoat
Negative-working imageable element can be used to provide lithographic printing plates. The imageable element has a suitable radiation-sensitive imageable layer and a water-soluble overcoat disposed on the imageable layer. This overcoat comprises at least one poly(vinyl alcohol) having a saponification degree of at least 90%, an alkoxylation product of an alkanol, and either a 2-sulfonato succinic acid dialkylester or an alkoxylation product of a 1,4-butanediol. |
| US08318400B2 |
Method of preparing toner and the toner, and developer and image forming method using the toner
A method of preparing a toner, including periodically discharging a toner constituent liquid from plural nozzles having the same aperture diameter with a mechanical oscillator, wherein the toner constituent liquid includes: a binder resin, a colorant, and an organic solvent, wherein the binder resin and the colorant are dissolved or dispersed in the organic solvent; forming a droplet of the toner constituent liquid in a gas phase; and solidifying the droplet, wherein the aperture diameter is from 3 to 30 μm, and the binder resin has a ratio (Mw/Mn) of a weight-average molecular weight (Mw) to a number-average molecular weight (Mn) of THF (tetrahydrofuran)-soluble components therein of from 1.5 to 15 in a molecular weight distribution measured by GPC (gel permeation chromatography), and a ½ flow temperature (Tm) of from 114 to 149° C. |
| US08318399B2 |
Electrostatic charge image development carrier, electrostatic charge image developer, process cartridge, image forming apparatus, and image forming method
An electrostatic charge image development carrier includes magnetic core particles and a resin coating layer that contains titanium dioxide particles doped with niobium and coats each of the magnetic core particles. |
| US08318394B2 |
Sulfonamide containing photoconductors
A photoconductor that includes a supporting substrate, an optional ground plane layer, an optional hole blocking layer, an optional adhesive layer, a photogenerating layer, and at least one charge transport layer, and where the charge transport layer or layers contains a sulfonamide. |
| US08318393B2 |
Optical-image-intensity calculating method, pattern generating method, and manufacturing method of semiconductor device
According to the embodiment, an optical image intensity distribution to be formed in a resist arranged on a lower layer side of a diffraction pattern is calculated by performing a whole image exposure from an upper surface side of the diffraction pattern formed on a substrate. The optical image intensity distribution is calculated by using a multimode waveguide analysis model or a fractional Fourier transform with respect to the diffraction pattern. |
| US08318392B2 |
Alignment method and method for manufacturing flat panel display
An alignment method is disclosed, in which a distance between a substrate and a photomask is set at a predetermined exposure gap. The photomask is rectangular, and includes a first side, and a second side opposite to the first side. A distance between a midpoint of the first side and the substrate is matched with the exposure gap. The photomask is rotated about, as an axis, a line that connects the midpoint of the first side and a midpoint of the second side to each other, whereby distances between both ends of the first side and the substrate are individually matched with the exposure gap. The photomask is rotated about the first side taken as an axis, whereby a distance between the midpoint of the second side and the substrate is matched with the exposure gap. |
| US08318390B2 |
Halftone mask having shielding parts and plural overapping halftone patterns of different widths
A halftone mask includes shielding parts partially formed on a transparent substrate; a lower portion halftone transmission pattern partially formed between the shielding parts on the transparent substrate; and an upper potion halftone transmission pattern partially formed on the lower portion halftone transmission layer pattern, where the lower portion halftone transmission pattern is partially exposed in a gap between the shielding parts and the upper portion halftone transmission pattern. |
| US08318385B2 |
Process for producing fuel cell electrode
Disclosed are processes for producing a fuel cell electrode and a membrane electrode assembly. In one preferred embodiment, the process comprises (a) preparing a suspension of catalyst particles dispersed in a liquid medium containing a polymer dissolved or dispersed therein; (b) dispensing the suspension onto a primary surface of a substrate selected from an electronically conductive catalyst-backing layer (gas diffuser plate) or a solid electrolyte membrane; and (c) removing the liquid medium to form the electrode that is connected to or integral with the substrate, wherein the polymer is both ion-conductive and electron-conductive with an electronic conductivity no less than 10−4 S/cm and ionic conductivity no less than 10−5 S/cm and the polymer forms a coating in physical contact with the catalyst particles or coated on the catalyst particles. |
| US08318380B2 |
Fuel cell and vehicle having fuel cell
A fuel cell has: an electrolyte; an anode provided on one side of the electrolyte and having a fuel-gas consuming face at which fuel gas is consumed; a cathode provided on the other side of the electrolyte and having an oxidizing-gas consuming face at which oxidizing gas is consumed; and a fuel-gas passage portion forming a passage through which fuel gas is supplied to predetermined regions of the fuel-gas consuming face of the anode. The fuel cell has an operation mode in which almost the entire amount of the supplied fuel gas is consumed at the fuel-gas consuming face of the anode. |
| US08318377B2 |
Membrane-electrode junction agent, proton conducting membrane having junction layer, membrane-electrode assembly, polymer electrolyte fuel cell, and manufacturing method of the membrane-electrode assembly
A membrane-electrode junction agent, a proton conducting membrane having a junction layer, a membrane-electrode assembly, a polymer electrolyte fuel cell, and a manufacturing method of the membrane-electrode assembly, which enhance the power generation performance, realize the high fuel barrier property, and are capable of enhancing the joint strength between the membrane and the electrodes, is provided. A membrane-electrode junction agent that joins a proton conducting membrane and electrodes arranged on both surfaces of the proton conducting membrane to each other, the membrane-electrode junction agent including: a cross-linked compound (X) having a silicon-oxygen bond; a polymer material (Y) containing an acid group; and a hydrophilic resin (Z) containing no acid group. |
| US08318375B2 |
Cathode for electrochemical reactor, electrochemical reactor incorporating such cathodes and method for making said cathode
A cathode for an electrochemical reactor including a diffusion layer and a catalyst layer. The cathode has bimetallic or multimetallic nanoparticles, dispersed in direct contact with the diffusion layer, at least one of the metals being chromium (Cr) wholly or partly in oxidized form. The cathode is fabricated by depositing the bimetallic or multimetallic nanoparticles on the diffusion layer by DLI-MOCVD in the presence of O2. |
| US08318373B2 |
Fuel cell assembly
An MEA comprising: (i) a central first conductive gas diffusion substrate having a first face and a second face; (ii) first and second catalyst layers each having a first and second face and wherein the first face of the first catalyst layer is in contact with the first face of the gas diffusion substrate and the first face of the second catalyst layer is in contact with the second face of the gas diffusion substrate; (iii) first and second electrolyte layers each having a first and second face and wherein the first face of the first electrolyte layer is in contact with the second face of the first catalyst layer and the first face of the second electrolyte layer is in contact with the second face of the second catalyst layer; (iv) third and fourth catalyst layers each having a first and second face and wherein the first face of the third catalyst layer is in contact with the second face of the first electrolyte layer and the first face of the fourth catalyst layer is in contact with the second face of the second electrolyte layer; and (v) first and second porous current collecting means each having a thickness of less than 400 m, and each having a first and second face and wherein the first face of the first current collecting means is in contact with the second face of the third catalyst layer and the first face of the second current collecting means is in contact with the second face of the fourth catalyst layer is disclosed and a fuel cell comprising such an MEA. |
| US08318370B2 |
Periodic flow heat exchanger
A heat exchanger includes a first regenerator core and a second regenerator core and a four-way valve coupled to a cold section of the first regenerator core and to a cold section of the second regenerator core. The four-way valve directs input air to the first regenerator core or to the second regenerator core. A high-temperature passive check valve is coupled to a hot section of the first regenerator core and to a hot section of the second regenerator core. The high-temperature passive check valve comprises an inlet header coupled to the hot section of the first regenerator core or the second regenerator core, a valve poppet coupled to a valve stem and a valve seat located on a surface parallel to a surface of the valve poppet. Air entering the inlet header moves the valve poppet away from the valve seat, creating an opening through which air passes. |
| US08318368B2 |
Portable systems for engine block
Described herein are portable fuel cell systems for producing electrical energy. The portable fuel cell systems include a fuel processor including a reformer and a burner. The reformer receives fuel and outputs hydrogen using the fuel. The burner processes fuel to generate heat. The system also includes a fuel cell configured to produce electrical energy using hydrogen output by the reformer. The system also includes a heat exchanger configured to transfer heat generated in the fuel cell or generated in the fuel processor to a reactant fluid. |
| US08318366B2 |
Hydrogen generator and fuel cell using the same
A hydrogen generator and a fuel cell using the same includes: a first container containing an aqueous solution of alkaline metal carbonate or bicarbonate; a second container containing a metal hydride; and a supply unit disposed between the first container and the second container. The hydrogen generator has a high hydrogen generating rate, can provide a fuel cell with a high energy density, and the amount of hydrogen generated thereby is easy to control. |
| US08318364B2 |
Fuel cell system
A fuel cell system includes a fuel cell stack for generating power and power generation control means. The fuel cell stack has at least one cell that includes a cathode to which an oxidant is supplied, an anode to which a fuel is supplied, and a polymer electrolyte membrane sandwiched between the cathode and the anode. The power generation control means has dryness degree determination means for determining the degree of dryness of the fuel cell stack based on shut-down period. When the shut-down period is shorter than a predetermined period of time, the power generation control means supplies a gas for drying to the cathode for a predetermined period of time, to remove water remaining in the cathode. When the shut-down period is equal to or longer than the predetermined period of time, such a drying operation is not performed. |
| US08318362B2 |
Fuel cell with electrolyte condensation zone
A fuel cell 12 has a liquid electrolyte 20, a cathode electrode 28, and an anode electrode 26. The fuel cell includes an electrolyte condensation zone 58 extending from an edge 56 of a first catalyst layer 36 on the cathode electrode to an outer edge 48 of an edge seals 52 and 49. An anode electrode has an anode catalyst layer 30 with an end substantially coinciding with an inner edge 53 of the edge seals. The acid condensation zone is located near the reactant exit, so that electrolyte that has evaporated into the reactant stream can condense out before leaving the fuel cell for re-absorption back into the fuel cell. |
| US08318361B2 |
Gel polymer electrolyte and electrochemical device comprising the same
Disclosed is a composition for a gel polymer electrolyte, the composition comprising: (i) a cyclic compound as a first crosslinking agent, the cyclic compound containing a cyclic group at the center thereof and having at least three double bonds at the end thereof; (ii) a linear or branched compound as a second crosslinking agent, the linear or branched compound containing an oxyalkylene group at the center thereof and having at least two (meth)acryl groups at the end thereof; (iii) an electrolyte solvent; (iv) an electrolyte salt; and (v) a polymerization initiator. Also, disclosed are a gel polymer electrolyte formed by polymerizing the composition for a gel polymer electrolyte, and an electrochemical device comprising the gel polymer electrolyte. |
| US08318360B2 |
Organic/inorganic composite porous membrane and electrochemical device using the same
The present invention provides an organic/inorganic composite porous separator, which comprises: (a) a porous substrate having pores; and (b) an organic/inorganic composite layer formed by coating at least one region selected from the group consisting of a surface of the substrate and a part of pores present in the substrate with a mixture of inorganic porous particles and a binder polymer, wherein the inorganic porous particles have a plurality of macropores with a diameter of 50 nm or greater in the particle itself thereby form a pore structure, a manufacturing method thereof, and an electrochemical device using the same. As an additional pathway for lithium ions is created due to a number of pores existing in the inorganic porous particle itself, degradation in the battery performance can be minimized, and energy density per unit weight can be increased by the weight loss effect. |
| US08318355B2 |
Carbon-carbon composite particles, their preparation and use therefore as negative electrode for li-ion batteries
A composite of particles comprising a high crystallinity carbon and a low crystallinity carbon, wherein the low crystallinity carbon exhibits an average lattice constant d=(002) of 0.350 nm or more and a crystallite size L=(002) in the diffraction of C axis of 25 nm or less, as characterized by wide-angle X ray diffraction measurements, the high crystallinity carbon exhibits an average lattice constant d=(002) of 0.338 nm or less and a crystallinity size L=(002) in the diffraction of C axis of 40 nm or more, as characterized by wide-angle X-ray diffraction measurements, the high crystallinity carbon having at least 50% of its external surface embedded within or surrounded by a matrix of low crystallinity carbon. |
| US08318351B2 |
Nonaqueous electrolyte battery containing a negative electrode of lithium-titanium composite oxide, battery pack and vehicle
A nonaqueous electrolyte battery, containing a case and provided in the case, a positive electrode, a negative electrode and a nonaqueous electrolyte. The negative electrode comprises a lithium-titanium composite oxide, wherein a crystallite diameter of the lithium-titanium composite oxide is not larger than 6.9×102 Å. The lithium-titanium composite oxide comprises: rutile TiO2; anatase TiO2; Li2TiO3; and a lithium titanate having a spinel structure. A main peak intensity relative to lithium titanate set at 100, as determined by X-ray diffractometry, of each of lithium titanate having a spinel structure, the rutile TiO2, the anatase TiO2 and Li2TiO3 is not larger than 7. |
| US08318349B2 |
Negative electrode active material for nickel-metal hydride battery and nickel-metal hydride battery using the same, and method for treating negative electrode active material for nickel-metal hydride battery
A negative electrode active material for a nickel-metal hydride battery of the present invention includes a hydrogen storage alloy, the hydrogen storage alloy containing La, Mg, Ni, Co, Al, and element M. The molar ratio y of Ni to the total of La and Mg is 2≦y≦3, the molar ratio z of Co to the total of La and Mg is 0.25≦z≦0.75, the molar ratio α of Al to the total of La and Mg is 0.01≦α≦0.05, and the molar ratio x of Mg to the total of La and Mg is 0.01≦x≦0.5. Element M represents at least one selected from the group consisting of Y and Sn, and the content of element M in the hydrogen storage alloy is 0.4 wt % or less. |
| US08318348B2 |
Pouch-type secondary battery
A pouch-type secondary battery including: an electrode assembly comprising a positive electrode plate, a negative electrode plate and a separator; a negative electrode tab electrically connected to the negative electrode plate and having a first tab tape; and a positive electrode tab electrically connected to the positive electrode plate and having a second tab tape wherein one or two of end portions which the positive electrode tab crosses are located inside a sealing portion. |
| US08318345B2 |
Electrode assembly and lithium rechargeable battery using the same
An electrode assembly comprising an electrode tab or an electrode plate substrate which has an identification mark formed thereon and a lithium rechargeable battery using the same are disclosed. This identification mark makes it possible to easily check the record of the manufacturing processes of the battery, including production equipment, production date, line operators, and production lines when a battery malfunctions. This identification mark may prevent a replica of the defective component from being manufactured. |
| US08318344B2 |
Negative electrode for lithium battery and lithium battery including the same
A negative electrode for a lithium battery includes an active material layer and a current collector. The active material layer has a plurality of crystal grains and the plurality of crystal grains include a plurality of pores. A first pore of the plurality of pores has a first length and a second length, the first length being the maximum length orthogonal to the current collector and the second length being the maximum length orthogonal to the first length, and the first length is greater than the second length. |
| US08318341B2 |
Pouch-type secondary battery
A pouch-type secondary battery including: an electrode assembly having a first electrode plate, a second electrode plate, and a separator disposed therebetween; and a pouch case including a first case part having a pouch to house the electrode assembly, a second case part disposed over an open end of the pouch, and sealing portions to seal the second case part to the first case part. The sealing portions include wing portions that are bent to cover opposing sides of the pouch, and bent portions that are bent from the wing portions, to cover a bottom surface of the pouch. |
| US08318340B2 |
Alkaline electrochemical cell with reduced gassing
Electrochemical cells including a casing or cup for direct electrical contact with a negative electrode or counter electrode and serving as the current collector for the electrode. The casing includes a substrate having a plated coating of an alloy including copper, tin and zinc, the coating having a composition gradient between the substrate and the external surface of the coating wherein the copper content is greater adjacent the substrate than at the external surface of the coating and the tin content is greater at the external surface of the coating than adjacent the substrate. Methods for forming a coated casing and an electrochemical cell including a coated casing are disclosed, preferably including providing an electrode casing with a coating utilizing variable current density plating that reduces discoloration of a surface exposed to the ambient atmosphere. |
| US08318334B2 |
Battery casing for electrical device
A battery casing used in an electrical device includes a box body, an electric sheet, a resilient electric portion and a switch apparatus. The box body for receiving a battery has a first sidewall and a second sidewall opposite to the first sidewall. The electric sheet mounted on an inner surface of the first sidewall is capable of electrically connecting with a first electrode of the battery. The resilient electric portion mounted on an inner surface of the second sidewall is capable of electrically connecting with a second electrode of the battery, and compressible to generate restoring forces. The switch apparatus mounted on an outer side of the first sidewall switches between a first position and a second position. When the switch apparatus is in the first position, the first electrode of the battery is detached from the electric sheet. |
| US08318333B2 |
Battery pack and method for producing the same
A battery pack includes a battery including a battery element covered with a packaging member, a battery protection circuit board, a covering material, and a rippable portion formed in a part of the covering material. The battery element includes a positive electrode and a negative electrode which are spirally wound or stacked through a separator. The covering material collectively covers the battery and the battery protection circuit board. The rippable portion rips open due to a gas generated from the battery in the event of an abnormal condition to form a gas release hole for releasing the gas outside the battery pack. |
| US08318326B2 |
Fused polycyclic compounds and organic light-emitting device using the same
A fused polycyclic compounds is represented by the general formula (I): wherein X1 to X18 each represent, independently of one another, a hydrogen atom, a halogen atom, a cyano group, a nitro group, a substituted or unsubstituted alkyl group, a substituted or unsubstituted alkoxy group, a substituted or unsubstituted alkenyl group, a substituted or unsubstituted alkynyl group, a substituted or unsubstituted aralkyl group, a substituted amino group, a substituted or unsubstituted aryl group, or a substituted or unsubstituted heterocyclic group. |
| US08318320B2 |
Adhesiveless copper clad laminates and method for manufacturing thereof
An adhesiveless copper clad laminate, which does not have defects on a copper film part due to a pin hole generated at the time of forming a base metal layer on an insulating film by dry plating process, has excellent adhesion between the insulating film and the base metal layer and corrosion resistance, and has a copper film layer having high insulation reliability The adhesiveless copper clad laminate is provided by forming a base metal layer directly at least on one plane of an insulating film without having an adhesive in between, and then by forming a copper film layer on the base metal layer, the base metal layer having a film thickness of 3 to 50 nm is formed by dry plating method and mainly contains a chrome-molybdenum-nickel alloy wherein the chrome ratio is 4 to 22 weight %, the molybdenum ratio is 5 to 40 weight %, and the balance is nickel. |
| US08318318B2 |
Lyocell web product
A web comprising a layer of crosslinked cellulosic fiber overlaid on and integral with at least one layer of regenerated cellulose fiber. The crosslinked cellulosic fiber can be sandwiched between two regenerated cellulose fiber layers. The regenerated cellulose can be viscose or lyocell. |
| US08318314B2 |
Barrier film for flexible copper substrate and sputtering target for forming barrier film
A barrier film for a flexible copper substrate comprising a Co—Cr alloy film containing 5 to 30 wt % of Cr and a balance of unavoidable impurities and Co is provided. The barrier film has a thickness of 3 to 150 nm and a film thickness uniformity of 10% or less at 1σ. A sputtering target for forming a barrier film comprising a Co—Cr alloy containing 5 to 30 wt % of Cr and a balance of unavoidable impurities and Co is also provided. The relative magnetic permeability in the in-plane direction of the sputtered face of the target is 100 or less. The barrier film for a flexible copper substrate and the sputtering target for forming such barrier film have a film thickness that is thin enough to prevent film peeling and inhibiting the diffusion of copper to a resin film such as polyimide, is capable of obtaining a sufficient barrier effect even in a minute wiring pitch and has barrier characteristics that will not change even when the temperature rises due to heat treatment or the like. |
| US08318310B2 |
Polyisocyanate coating compositions cross-linkable into enhanced anti-shock coatings
Polyisocyanate coating compositions, the polyisocyanates of which include dimer structural units (patterns) and imino-trimer structural units (patterns), are converted, via cross-linking, into useful such coatings as paints or varnishes having enhanced shock-resistant properties, notably chip-resistant properties for vehicle body parts. |
| US08318306B2 |
Superabsorbent polymer compositions having a triggering composition
The present invention relates to absorbent compositions which exhibit swelling, deswelling, and reswelling behavior. More specifically, absorbent compositions of this invention swell and absorb fluids after exposure to aqueous fluids, deswell and release fluids from the swollen absorbent compositions, and may also reswell and absorb fluids. The swelling-deswelling-reswelling behavior allows enhanced liquid distribution in absorbent composites. |
| US08318299B2 |
Fire resistance for optically transparent thermoplastics
A fire retardant, transparent panel and method of making the panel, that is especially well suited for use on mobile platforms, and particularly on aircrafts. The panel is a composite of a transparent matrix and a plurality of fire-retardant nanoparticles. The nanoparticles have a diameter less than the visible spectrum of light, and in one form between about 0.1 nm to about 400 nm in diameter. The nanoparticles may be arranged randomly or in predetermined patterns within the matrix during manufacturing of the panel. The panel is lightweight, transparent and yet highly fire retardant. |
| US08318298B2 |
Layered sheets and processes for producing the same
Provided herein is a process for producing a layered sheet. The process involves preparing a cell dispersed urethane composition by a mechanical foaming method. The cell dispersed urethane composition is applied to a base material sheet and cured to produce a polyurethane foam layer of uniform thickness. A releasing sheet may be utilized to make the thickness of the polyurethane foamed layer uniform. Also, provided herein is a layered sheet produced by the above process. The polyurethane foamed layer may have spherical fine cells having an average cell diameter of 20 to 300 μm. The polyurethane foamed layer may have a specific gravity of 0.2 to 0.5. The polyurethane foamed layer may also have a Asker C hardness of 10 to 50 degrees. |
| US08318297B2 |
Titanate nanowire, titanate nanowire scaffold, and processes of making same
In one aspect, the present invention relates to a synthetic nanostructure. In one embodiment, the synthetic nanostructure has a top region substantially comprising titanate nanowires, a middle region substantially comprising titanate nanoparticles and titanate nanowires, and a bottom region substantially comprising titanium, wherein some of the titanate nanowires of the top region are extending into the middle region, wherein the middle region is between the top region and the bottom region, and wherein some of the titanate nanowires of the top region are substantially perpendicular to the bottom surface of the titanium substrate. At least some of the titanate nanowires in the top region form 3D macroporous scaffolds with interconnected macropores. |
| US08318295B2 |
Carbon nanotube composite structure
A carbon nanotube composite structure includes a matrix and a carbon nanotube structure. The matrix has a surface. The carbon nanotube structure is incorporated in the matrix. A distance between the carbon nanotube structure and the surface is less than 10 micrometers. The carbon nanotube structure includes a plurality of carbon nanotubes joined with each other by van der Waals attractive force. |
| US08318292B2 |
Resin sheet with copper foil, multilayer printed wiring board, method for manufacturing multilayer printed wiring board and semiconductor device
A resin sheet with a copper foil, comprising: a carrier layer; a copper foil layer having a thickness 0.5 to 5 μm provided over the carrier layer; and an insulating resin layer formed over the copper foil layer, wherein the insulating resin layer is once abutted with base material, and then the carrier layer is delaminated from the copper foil layer, and wherein the insulating resin layer contains a cyanate ester resin having phenolic novolac backbone and a polyfunctional epoxy resin. |
| US08318291B2 |
Composite member defining a contour surface
A composite member and an associated method for forming the composite member are provided. The composite member is formed of a plurality of elongate tapes. Each tape is disposed a path defined by a plurality of natural path segments, each of which defines a non-natural offset angle relative to the adjacent segments. |
| US08318288B2 |
Optical element, lithographic apparatus including such optical element and device manufacturing method, and device manufactured thereby
An optical element includes a top layer which is transmissive for EUV radiation with wavelength λ in the range of 5-20 nm, and a structure of the top layer is a structure having an rms roughness value equal to or larger than λ/10 for spatial periods equal to or smaller than λ/2. The structure promotes transmission through the top layer to the optical element. |
| US08318284B2 |
Capped tufted laminate web
A laminate web having a nonwoven web in facing relationship with a polymer film. The laminate web has a first side comprising the polymer film and a plurality of discrete tufts including fibers integral with and extending from the nonwoven web. Each of the tufts has a tuft base proximal to the nonwoven web and a distal portion opposing the tuft base. At least part of the distal portion of each of the tufts is covered by a cap, each cap being an integral extension of said polymer film extending over the distal portion of a discrete tuft. The cap has a first opening including a location of rupture in the polymer film above which the tuft extends. |
| US08318280B2 |
Sealing tape of soft foam and method for its production
A compressed and re-expandable soft foam sealing tape, which is provided on one side with a self-adhesive layer covered by a cover film, and rolled up into a roll, is provided. A flexible film strip is inserted between the adhesive surface and the cover film at least along its edge on one side of the sealing tape roll and is adhered to the adhesive surface. The remaining film strip is folded over the sealing tape roll and inserted between the soft foam layer, to which the portion of the film strip has been adhered, and the cover film adhering to the adjacent soft foam layer. |
| US08318279B1 |
Vehicle sticker film intermediary
A sticker assembly includes an indicia-bearing sticker (30) having an adhesive layer (34). A vinyl film (20) is provided having a first side (22) and a second side (24), the second side (24) having a low-tack adhesive (25) thereon. The first side (22) of the vinyl film (20) is adhered to the adhesive layer (34) of the sticker (30). The second side (24) of the vinyl film (20) is applied to a receiving surface (12) and held against the surface (12) by the low-tack adhesive (25) wherein the vinyl film (20) and the sticker (30) are releasably adhered to the receiving surface (12) and wherein the indicia-bearing sticker (30) is displayed for viewing. In one embodiment, the sticker (30) is a vehicle windshield sticker and the receiving surface (12) is a vehicle windshield. |
| US08318278B2 |
Adhesive attachment and method
An easy to use epoxy-mount base plate assembly has components of a two-part epoxy adhesive pre-dispensed on the assembly's base plate in a plurality of alternating segments and prepackaged with a protective adhesive cover that keeps each epoxy component segment separated from one another until ready for use. To attach the base plate of the assembly to a surface, the adhesive cover is removed exposing the epoxy segments. The base plate is then pressed against a mounting surface and twisted thus mixing the epoxy components and initiating a curing process for the epoxy. |
| US08318276B2 |
Substrates with barrier properties at high humidity
The invention relates to a substrate comprising a layer of crystalline triazine with a protective compound having a retention of oxygen barrier at 85% RH of about 50% or better. The protective compound preferably contains an azine-formaldehyde or phenol-formaldehyde resin, preferably with an hydroxy-functional polymer, and is cured. |
| US08318273B2 |
Glassware structure with metal cladding
A glassware structure with metal cladding for decorative effect having a main body and a metal cladding incorporated onto the surface of the main body by means of vacuum vapor deposition. The main body has an assembly portion and an acting portion. The metal cladding is distributed at least within the range of the acting portion. The tensile strength of the main body ranges between 120 and 200MPa (N/mm2), the thickness of the metal cladding between 0.1 and 1.0μm, and the coverage ratio between 95% and 100%. The metal cladding material is selected from zirconium nitride, nickel nitride, molybdenum nitride, titanium nitride, chromium nitride and silicon nitride. As the metal cladding and the main body can be securely fixed, the present invention can be used instead of metal castings and tubes. The glassware produces light transmittance effect, improving shape design flexibility, novelty and value of the glassware. |
| US08318271B2 |
Heat transferable material for improved image stability
A heat transferable material includes a heat transferable polymeric binder and a light stabilizer that is an N-oxyl radical derived from a hindered amine, the N-oxyl radical having the following formula, wherein R1, R2, R5, and R6 are each independently selected from a straight or branched C1-C6 alkyl, and R3 and R4 are each independently selected from H, OH, OR, COOH, or COOR, wherein R is a straight or branched C1-C6 alkyl or alkene, and having a molecular weight of 600 or less, is described. The heat transferable material can be in one or more sections or patches on a thermal donor element to provide a protective overcoat material. Optionally, a patch in the donor element can also include a dye. The heat transferable material provides better image stability and improved iridescence when applied to a thermal, inkjet, electophotographic, or silver halide receiver. |
| US08318266B2 |
Enhanced copper growth with ultrathin barrier layer for high performance interconnects
A method for depositing a refractory metal nitride barrier layer having a thickness of about 20 angstroms or less is provided. In one aspect, the refractory metal nitride layer is formed by introducing a pulse of a metal-containing compound followed by a pulse of a nitrogen-containing compound. The refractory metal nitride barrier layer provides adequate barrier properties and allows the grain growth of the first metal layer to continue across the barrier layer into the second metal layer thereby enhancing the electrical performance of the interconnect. |
| US08318260B2 |
Method for electroless deposition of nano metallic silver and reflector of high reflectance deposited by nano metallic silver using the same
The present invention relates to an electroless deposition of metallic silver on various plates. More particularly, in the present invention, by spraying a silver solution including ionic silver to be reduced into metallic silver and a reducing solution a reducing agent for reducing the silver solution at the same time to a predetermined region above a substrate, metallic silver particles having a diameter less than 30 Å are formed, and a silver layer is formed by a deposition of the nano-sized metallic silver.Since the silver layer includes nano-sized silver particles having a diameter less than 3 nm, a reflector having a high density, that is, surface roughness, can be manufactured. The reflector has a considerably excellent reflectance. |
| US08318258B2 |
Silsesquioxane resins
Silsesquioxane resins useful in antireflective coatings wherein the silsesquioxane resin has the formula (PhSiO(3−x)/2(OR′)x)m(HSiO(3−x)/2(OR′)x)n(MeSiO(3−x)/2(OR′)x)o(RSiO(3−x)/2(OR′)x)p(R2SiO(3−x)/2(OR′)x)q where Ph is a phenyl group, Me is a methyl group; R is selected from a sulfur-containing organic functional group; R′ is hydrogen atom or a hydrocarbon group having from 1 to 4 carbon atoms; R2 is selected from ester groups, polyether groups; and polyethylene oxide groups; x has a value of 0, 1 or 2; m has a value of 0.01 to 0.97; n has a value of 0.01 to 0.97; o has a value of 0.01 to 0.97; p has a value of 0.01 to 0.97; q has a value of 0 to 0.96; and m+n+o+p+q≈1. |
| US08318256B2 |
Metallic material and method of manufacturing the same
A metallic material is provided that is superior to an iron-based metallic material in all of adhesion, heat resistance, electrical conductivity, and corrosion resistance, and a method of manufacturing the metallic material is also provided. A metallic material is provided that includes an iron-based metallic material and an oxide layer formed on the surface of the iron-based metallic material. The oxide layer includes Fe and at least one kind of metal (A) selected from a group consisting of Zr, Ti, and Hf. There is also provided a method of manufacturing the metallic material. |
| US08318254B2 |
Metallization on a surface and in through-holes of a substrate and a catalyst used therein
A copolymer deposited with particles of catalytic metal is disclosed in the present invention, which is formed from an ethylenically unsaturated monomer and a hydrophilic monomer, and the catalytic metal is Au, Ag, Pd, Pt or Ru. The copolymer is hydrophilic when the temperature is lower than a specific temperature, and will become hydrophobic when the temperature is greater than the specific temperature. The present invention also discloses a method for forming a metal layer on a substrate via electroless plating, which includes contacting the substrate with an ink composition, drying the ink composition on the substrate, and contacting the dried ink composition with an electroless plating solution, wherein the ink composition contains the copolymer of the present invention in an aqueous phase. The present invention further discloses a method for forming metal conductors in through holes of a substrate. |
| US08318249B2 |
Method for selective deposition and devices
A chemical vapor deposition method such as an atomic-layer-deposition method for forming a patterned thin film includes applying a deposition inhibitor material to a substrate. The deposition inhibitor material is a hydrophilic poly(vinyl alcohol) having a degree of hydrolysis of less than 95%. The deposition inhibitor material is patterned simultaneously or subsequently to its application to the substrate, to provide selected areas of the substrate effectively not having the deposition inhibitor material. A thin film is substantially deposited only in the selected areas of the substrate not having the deposition inhibitor material. |
| US08318241B2 |
Method of manufacture of an electrode for a fuel cell
A method of manufacture of an electrode for a fuel cell, the method comprising at least the steps of: (a) providing an electrode substrate; (b) contacting at least a part of the electrode substrate with an electroless plating solution comprising a reducing agent, a metal precursor and a suspension of particulate material; and (c) electrolessly plating the metal from the metal precursor onto the contacted part of the electrode substrate, thereby co-depositing the particulate material on the contacted part of the electrode substrate to provide the electrode. |
| US08318240B2 |
Method and apparatus to remove a segment of a thin film solar cell structure for efficiency improvement
The present inventions relate to methods and apparatus for detecting and mechanically removing defects and a surrounding portion of the photovoltaic layer and the substrate in a thin film solar cell such as a Group IBIIIAVIA compound thin film solar cell to improve its efficiency. |
| US08318237B2 |
Pixel observation system, drawing system, liquid material drawing method, color filter manufacturing method, and organic EL element manufacturing method
A pixel observation system includes a memory unit, a coordinate generation unit, and an observation unit. The memory unit is configured to store at least nozzle information indicative of discharge states of a liquid material in a plurality of nozzles and arrangement information indicative of an arrangement of each of the nozzles with respect to each of a plurality of pixel regions in relative movement of the nozzles and a substrate. The coordinate generation unit is configured to generate observation coordinates of observation regions on the substrate based on the nozzle information and the arrangement information, and to include coordinates of at least some of the pixel regions over which the nozzles scan through one cycle of the relative movement in the observation coordinates. The observation unit is configured and arranged to observe the pixel regions positioned at the observation coordinates generated by the coordinate generation unit. |
| US08318230B2 |
Use of debranched starch in extrusion-spheronization pharmaceutical pellets
This patent pertains to the use of debranched starch in the preparation of pharmaceutical pellets by extrusion spheronization. Such excipients are useful in any dry dosage form, including tablets and capsules, for either immediate or sustained release. |
| US08318229B2 |
Method for controlling bulk density of fried snack pieces
A method and apparatus to impart a random curvature to frying pre-formed snack pieces in a multi-layer fryer through the use of a contoured submerger. The shape of the contours of a contoured submerger imparts a random final curvature to each snack piece as snack pieces pass through a glass transition during frying. The contours are chosen so as to achieve a desired bulk density for the packaged fried snack products. Such method and apparatus are also useful in controlling the amount of change in bulk density or amount of settling of a packaged product during shipping or handling. |
| US08318228B2 |
Method for production of processed and roasted coffee bean
The present invention provides refined roasted coffee beans having a Hunter L value of 10 to 30 and a hydroxyhydroquinone content of not higher than 30 mg/kg by contacting an aqueous solvent with raw material roasted coffee beans. The invention also provides a process for producing refined roasted coffee beans, which includes contacting raw material roasted coffee beans having a Hunter L value of 12 to 35, with coffee bean-derived extract-containing water selected from water containing an extract derived from roasted coffee beans having a Hunter L value of 40 or more and water containing an extract derived from raw coffee beans. |
| US08318224B2 |
Composition for enhancing physical performance
This invention relates to a composition that contains quercetin, vitamin B1, vitamin B2, vitamin B3, vitamin B6, vitamin B12, vitamin C, caffeine, epigallocatechin gallate, epicatechin, epicatechin gallate, and epigallocatechin. |
| US08318217B2 |
Compositions comprising an anti-inflammatory blend
The present invention relates to a composition comprising an NFκB-inhibitor and an anti-inflammatory compound. The anti-inflammatory compound is not an NFκB-inhibitor and has an IC50 of about 70 μg/ml or less. |
| US08318215B1 |
Composition and method of preparing a tomato-based topical formulation for enhanced healing of burns, ultraviolet and radiation erythema
The present invention is a topical treatment. which can be in the form of cream, ointment, spray or other topically administered composition, which is used to enhance healing of burns, ultraviolet and radiation erythema. The treatment not only reduces pain and inflammation, prevents blistering, and maintains flexibility of the skin, but also accelerates the normal healing process. |
| US08318213B2 |
Plant extract mixtures and their uses
A composition comprising an effective amount of Cissus quadrangularis to reduce fat and cause weight loss in a mammal. Such compositions have beneficial activity principally in controlling weight gain and obesity. |
| US08318212B2 |
Cartilage composition and process for producing the cartilage composition
Disclosed is a method for regenerating articular cartilage in an animal comprising administering a therapeutically effective amount of a non-demineralized particulate articular cartilage having a distribution of particle sizes within the range of from about 60 microns to about 500 microns. |
| US08318210B2 |
Compositions and methods of making sustained release liquid formulations
The present invention includes compositions and methods for the controlled release of active agents in a shelf-stable liquid formulation by blending one or more controlled release microbeads comprising one or more active agents, preparing a dense, thixotropic solution having a density that is at, or about, the density of the one or more microbeads comprising a thixotropic agent, water and one or more preservatives under conditions that reduce bubble formation and mixing the microbeads and the thixotropic solutions in a mixer that lacks scraping paddles. |
| US08318208B1 |
Drug loaded polymeric nanoparticles and methods of making and using same
The present disclosure generally relates to nanoparticles having about 0.2 to about 35 weight percent of a therapeutic agent; and about 10 to about 99 weight percent of biocompatible polymer such as a diblock poly(lactic) acid-poly(ethylene)glycol. Other aspects of the invention include methods of making such nanoparticles. |
| US08318205B2 |
Polyethylene glycol/polycation block copolymers
The invention provides block copolymers formed of poly(ethylene glycol) segments and poly(amino acid derivative) segments having side chains of at least one kind of specific amine residue. The invention also provides polyion complexes of such copolymers with polynucleotides and the like. These block copolymers are useful as carriers for in vivo delivery of active substances such as DNA. |
| US08318202B2 |
Stable compositions of famotidine and ibuprofen
Stable pharmaceutical compositions of famotidine and ibuprofen in a single unit dosage form are disclosed herein. The compositions comprise a famotidine core having a reduced or minimal surface area surrounded by a layer of ibuprofen. In some embodiments, the ibuprofen is in direct physical contact with the famotidine. |
| US08318201B2 |
Method of stabilizing diarylvinylene compound
(wherein Y1 and Y2 may be the same or different and each represents a hydrogen atom, halogen or lower alkyl; and Z and A may be the same or different and each represents substituted or unsubstituted aryl, or substituted or unsubstituted heteroaryl) The present invention provides, for example, a method for stabilization of a diarylvinylene compound such as a compound represented by the above formula (I) or the like, or a pharmaceutically acceptable salt thereof in a solid formulation containing the diarylvinylene compound or the pharmaceutically acceptable salt thereof, which comprises allowing an inorganic substance and/or a colorant to exist in the solid formulation, and the like. |
| US08318200B1 |
Pharmaceutical composition of nanoparticles
The invention discloses a pharmaceutical composition of liposome nanoparticles for lodging in a target tissue cell in situ of an animal subject, the nanoparticles comprising at least one thermal triggered phase-transition compound as a targeting drug delivery system for physical cancer therapy. |
| US08318198B1 |
Pharmaceutical composition of nanoparticles
The invention discloses a pharmaceutical composition of liposome nanoparticles for lodging in a target tissue cell in situ of an animal subject, the nanoparticles comprising at least one thermal triggered phase-transition compound as a targeting drug delivery system for physical cancer therapy. |
| US08318197B2 |
Wound healing device and method
The invention is directed to a novel wound healing device. In particular, the invention is directed to a novel wound healing device comprising a suture or knitted mesh that has adsorbed onto it novel cellular factor-containing compositions (referred to herein as CFC), including Amnion-derived Cellular Cytokine Solution (referred to herein as ACCS) or Physiologic Cytokine Solutions (herein referred to as PCS), as well as methods of making and uses thereof. |
| US08318196B2 |
Formulations comprising a vitamin and the use thereof to make fortified feed and personal care formulations
The invention relates to aqueous formulations comprising alkoxylated castor oils with 15-25 ethyleneoxy units and a vitamin, preferably a fat-soluble vitamin, as well as to the use of such formulations in the process to administer the vitamin to an animal, or to make personal care formulations comprising the vitamin. |
| US08318191B2 |
Porous material having hierarchical porous structure and preparation method thereof
Disclosed are porous ceramic balls with a hierarchical porous structure ranging in size from nanometers to micrometers, and preparation methods thereof. Self-assembly polymers and sol-gel reactions are used to prepare porous ceramic balls in which pores ranging in size from ones of nanometers to tens of micrometers are hierarchically interconnected to one another. This hierarchical porous structure ensures high specific surface areas and porosities for the porous ceramic balls. Further, the size and distribution of the pores can be simply controlled with hydrophobic solvent and reaction time. The pore formation through polymer self-assembly and sol-gel reactions can be applied to ceramic and transition metals. Porous structures based on bioceramic materials, such as bioactive glass, allow the formation of apatite therein and thus can be used as biomaterials of bioengineering, including bone fillers, bone reconstruction materials, bone scaffolds, etc. |
| US08318189B2 |
Capsule medication administration system and medication administration method
A capsule medication administration system includes: a first capsule for internal body marking; a second capsule for medication; a marking device which makes a marking within a living body; a drug retention section which retains a drug; a release device which releases the drug; a detection device which detects the marking; a decision device which decides whether or not a marking which has been detected by the detection device is a specified marking; and a release control device which operates the release device, if it has been decided by the decision device that it is the specified marking; wherein the first capsule comprises the marking device. The second capsule comprises the drug retention section and the release device. |
| US08318188B2 |
Medium chain peroxycarboxylic acid compositions
The present invention relates to compositions including medium chain peroxycarboxylic acid, methods for making these compositions, and methods for reducing the population of a microorganism. The compositions can include advantageously high levels of the medium chain peroxycarboxylic acid, can be readily made, and/or can exhibit reduced odor. |
| US08318184B2 |
MGLU2 agonists
The present invention provides novel mGlu2 agonists useful in the treatment of bipolar disorder, schizophrenia, depression, and generalized anxiety disorder. |
| US08318179B2 |
Neisserial vaccines
The present invention relates to compositions comprising at least one purified PorA protein antigen and at least one purified FetA protein antigen. In particular, said PorA/FetA antigens are antigenically variable antigens comprising the variable regions of PorA/FetA. Specific combinations of PorA/FetA epitopes are presented for example in Table 3. The invention also relates to methods of immunization comprising administering said compositions, and to methods for producing compositions. Preferably the compositions are purified protein compositions. Preferably the compositions are vaccine compositions. |
| US08318177B2 |
Viral chemokine-antigen fusion proteins
The present invention relates to a vaccine for increasing the immunogenicity of a tumor antigen thus allowing treatment of cancer, as well as a vaccine that increases the immunogenicity of a viral antigen, thus allowing treatment of viral infection, including immunodeficiency virus (HIV) infection. In particular, the present invention provides a fusion protein comprising a viral chemokine fused to either a tumor antigen or viral antigen which is administered as either a protein or nucleic acid vaccine to elicit an immune response effective in treating cancer or effective in treating or preventing viral infection. |
| US08318176B2 |
Immunosuppressive polypeptides and nucleic acids
The invention provides immunosuppressive polypeptides and nucleic acids encoding such polypeptides. In one aspect, the invention provides mutant CTLA-4 polypeptides and nucleic acids encoding mutant CTLA-4 polypeptides. Compositions and methods for utilizing such polypeptides and nucleic acids are also provided. |
| US08318175B2 |
Method for treating amyloid disease
Disclosed herein are methods for treating amyloid disease in humans by clearing amyloid peptides from one or more bodily fluids such as, e.g. blood, of a patient. In particular, the methods are based on the administration of compounds capable of binding to amyloid-beta (Aβ) or on dialysis of blood or plasma exchange in order to remove Aβ peptides from the blood circulation, and/or brain or other affected organs. |
| US08318170B2 |
Methods for prevention and treatment of inflammation using anti-chemokine antibodies
It is possible to inhibit inflammatory processes by administration of antibodies to chemokines. Identification of chemokines which are over-produced makes it possible to block specific chemokine activity using antibodies to the over-expressed chemokines. |
| US08318168B2 |
Antigenic GM-CSF peptides and antibodies to GM-CSF
Hybridoma lines that secrete human monoclonal antibodies with high binding specificity and biological activity, particularly neutralizing activity against granulocyte-macrophage colony stimulating factor, and methods of generating the hybridoma lines are provided. Target antigens and epitopes are also provided. The antibodies may be used in therapeutic methods, for example in the treatment of cancer, infectious disease, or autoimmune disease. |
| US08318167B2 |
Methods and compositions for regulating iron homeostasis by modulation of BMP-6
Modulation of iron homeostasis by regulating BMP-6 activity is provided. Methods of using BMP-6 and BMP-6 protein-specific reagents, such as antibodies, for altering serum iron levels in humans are provided. Such antibodies are useful in pharmaceutical compositions for the prevention and treatment of hemochromatosis and anemia of inflammation. |
| US08318165B2 |
Antibodies against human melanoma-associated chondroitin sulphate proteoglycan (MCSP)
The present invention provides isolated antibodies (e.g., humanized or human antibodies) that bind to the membrane-proximal domain (MP) of human Melanoma-Associated Chondroitin Sulphate Proteoglycan (MCSP), and are capable of mediating cytolysis of a cell expressing MCSP in the presence of human effector cells or complement. Methods of using such antibodies to induce cytolysis (e.g., ADCC or CDCC) of cells expressing MP-MCSP are also provided. |
| US08318159B2 |
Anti-IGF antibodies
Antibody molecules, in particular fully human antibodies that bind to human IGF-1 and cross-react with IGF-2 such that binding of IGF-1 and IGF-2 to the IGF-1 receptor is prevented and IGF-1 receptor-mediated signaling is inhibited. The antibodies do not bind to insulin and thus do not affect the mitogenic properties of insulin that are mediated by its binding to the insulin receptors. The antibodies are useful for the treatment of hyperproliferative diseases, in particular cancer. |
| US08318157B2 |
Trichoderma reesei α-amylase enhances saccharification of corn starch
A maltogenic α-amylase from Trichoderma reesei (TrAA) and variants thereof in the presence of a glucoamylase are useful in the production of high-glucose syrups from liquefied starch, where the high-glucose syrups produced thereby contain at least about 97% glucose. In this process, TrAA advantageously suppresses the reversion of glucose to malto-oligosaccharides. Expression hosts and encoding nucleic acids useful for producing TrAA and its variants also are provided. |
| US08318154B2 |
Super fast-acting insulin compositions
Provided are combinations, compositions and kits containing an fast-acting insulin composition and a hyaluronan degrading enzyme composition formulated for parenteral administration. Such products can be used in methods of treating insulin-treatable diseases or conditions. Also provided are methods for administration of a fast-acting insulin and a hyaluronan degrading enzyme. |
| US08318153B2 |
Method of medically treating an individual
A method immunizing an individual that minimizes the amount of antigen or attenuated organism needed and the number of doses and clinic visits required, while making possible polyvalent simultaneous immunizations. The method comprises the steps of obtaining a sample of blood. Exposing at least a portion of this sample to at least one immunogenic antigen, attenuant or other immunogen. Incubating the exposed sample under specified optimal conditions and introducing this exposed sample into the individual to effect immunization thereof. The method of the invention also provides a method of delivery of materials, other than antigens, throughout an individual's body such as therapeutic drugs, virus vectors, genes, DNA, RNA, isotopes, and other therapeutic substances. A method for the delivery of treatment material to an individual is also provided by this method. |
| US08318149B2 |
Replication competent viruses capable of silencing virus inhibitory factor expression
Described is a replication-competent virus capable of replication and having lytic capacity in target cells. The virus comprises in the genome thereof, at least one DNA sequence coding for a silencing factor functional in reducing expression of a target gene in the target cells, operably linked to one or more expression control sequences, functional in the target cells. The use thereof in the preparation of a medicament and the use thereof in a method for lysing target cells expressing a virus inhibitory factor are also described. |
| US08318148B2 |
Attenuated bacteria useful in vaccines
The invention provides strains of bacteria, especially enterotoxigenic E. coli, attenuated by mutations in the genes encoding enterotoxins (LT, ST, EAST1) and optionally further attenuated by deletion of additional chromosomal genes. In addition the invention provides strains of attenuated bacteria expressing immunogenic but non-toxic variants of one or more of these enterotoxins. These bacteria are useful as a vaccine against diarrhoeal disease. |
| US08318146B1 |
Ascarosides as nematode sex pheromones
A pheromonal compound produced by Caenorhabditis elegans has been identified as 5R-(3′-O-[β-D-glucosyl]-tetrahydro-3′R,5′R-dihydroxy-6′S-methyl-2H-pyran-2′R-yloxy)-2-hexanone. The novel compound, in combination with other ascarosides, elicit a synergistic signaling response from various adult male Caenorhabditis spp. |
| US08318144B2 |
Use of PEO-PBO block copolymers in ophthalmic compositions
The use of poly(oxyethylene)-poly(oxybutylene) block copolymers in pharmaceutical compositions useful for modifying the surfaces of contact lenses and other medical devices is disclosed. The present invention is based in-part on a discovery that this class of compounds is particularly efficient in wetting hydrophobic surfaces, such as the surfaces of silicone hydrogel contact lenses and other types of ophthalmic lenses. Such compounds are also useful for cleaning purposes. The use of the compounds as surfactants in various types of compositions for treating contact lenses therefore represents a preferred embodiment of the present invention. |
| US08318143B2 |
Compositions for treating keratin-containing fibers and maintaining dyed fiber color integrity
Disclosed are compositions, inter alia, shampoos, conditioners, and restoratives that are effective in preventing further damage to keratin-containing fibers damaged by exposure to oxidative dyeing catalysts, mechanical damage, exposure to UV and visible radiation, and the like. |
| US08318141B2 |
Cosmetic depilatory composition
A cosmetic cold-wax depilatory composition is provided The depilatory composition comprises a hydrocarbon resin, from 50% to 99% by weight and a flexibilizer or plasticizer, from 0.5% to 10% by weight Methods of applying the composition to a strip of material for removal of hair without the need for heating are also provided. |
| US08318139B2 |
Composition for oral cavity
There is provided a composition for oral cavity containing a monofluorophosphoric acid, which can supply calcium ions in a stable manner. The composition comprises (A) a calcium ion-supplying compound which supplies calcium ions at 100 to 16000 ppm, (B) a monofluorophosphate ion-supplying compound which supplies monofluorophosphate ions at 250 to 25000 ppm, and (C) one or more acids selected from the group consisting of lactic acid, malic acid, and tartaric acid, and the composition has a pH of 4 to 6.2. |
| US08318134B2 |
Responsive paramagnetic MRI contrast agents
A method is claimed based on CEST procedure for the in vivo or in vitro determination of physical or chemical parameters which includes the use of a responsive paramagnetic CEST contrast agent. |
| US08318131B2 |
Chemical processes and reactors for efficiently producing hydrogen fuels and structural materials, and associated systems and methods
Chemical processes and reactors for efficiently producing hydrogen fuels and structural materials and associated systems and methods. A representative process includes dissociating a hydrogen donor into dissociation products by adding energy to the hydrogen donor, wherein the energy includes waste heat generated by a process other than dissociating the hydrogen donor. The process can further include providing, from the dissociation products, a structural building block and/or a hydrogen-based fuel, with the structural building block based on carbon, nitrogen, boron, silicon, sulfur, and/or a transition metal. |
| US08318129B2 |
Hydrotalcite imparting improved thermoresistance to resins and preparation method thereof
This invention relates to a partially dehydrated hydrotalcite obtained by heat-treating a hydrotalcite under a specific condition so that its weight is reduced by 1.5 to 5%, which is capable of imparting improved thermoresistance to a synthetic resin. |
| US08318127B1 |
Methods for preparing high crystallinity and surface area porous metal oxides
Exemplary embodiments provide materials and methods of forming a metal oxide composite and a porous metal oxide, which can be used for applications including catalysis, sensors, energy storage, solar cells, heavy metal removal and separations, etc. In one embodiment, a one-step solvothermal process can be used to form the metal oxide phase with high crystallinity and high surface area. |
| US08318124B2 |
Producing method and apparatus of carbon nanofibers
The present invention is provided with a reaction apparatus (12) that supplies carbon raw material (11) and fine particles (50) to cause carbon nanofibers to grow on surfaces of the fine particles (50), a heating apparatus (20) that heats the reaction apparatus 12, a recovery line (23) that recovers fine particles on which the carbon nanofibers have grown from the reaction apparatus, and a carbon nanofiber separating apparatus (24) that separates carbon nanofibers (52) from the recovered fine particles on which carbon nanofibers have been grown. |
| US08318122B2 |
Preparation of a carbon nanomaterial using a reverse microemulsion
Powdered, amorphous carbon nanomaterials are formed from a carbon precursor in reverse microemulsion that includes organic solvent, surfactant and water. Methods for manufacturing amorphous, powdered carbon nanomaterials generally include steps of (1) forming a reverse microemulsion including at least one non-polar solvent, at least one surfactant, and at least one polar solvent, (2) adding at least one carbon precursor substance to the reverse microemulsion, (3) reacting the at least one carbon precursor substance so as to form an intermediate carbon nanomaterial, (4) separating the intermediate amorphous carbon nanomaterial from the reverse microemulsion, and (5) heating the intermediate amorphous carbon nanomaterial for a period of time so as to yield an amorphous, powdered carbon nanomaterial. Amorphous, powdered carbon nanomaterials manufactured according to the present disclosure typically have a surface area of at least 500 m2/g, a graphitic content of at least 25%, and a conductivity of at least 150 S/m. |
| US08318121B2 |
Device and method for the processing of non-ferrous metals
In a device and a method for the processing of non-ferrous metals for simple and economic reduction of the concentration of impurity elements and/or impurity compounds contained in the non-ferrous metal, it is provided to gas the non-ferrous metal in a processing column with at least one gas at a low pressure, causing the impurity elements and/or impurity compounds to evaporate. |
| US08318117B2 |
Absorption medium and method for removing sour gases from fluid streams, in particular from flue gases
Absorption medium for acid gases comprising an oligoamine (A) of the general formula (I) and a primary or secondary alkanolamine (B) of the general formula (II) in which the weight ratio of oligoamine (A) to the primary or secondary alkanolamine (B) is 0.2 to 4, and also the process for removing acid gases from a gas stream by contacting the gas stream at a pressure of 0.05 to 10 MPa abs with an aqueous solution brought to and maintained at a temperature of 20 to 80° C. of said absorption medium. |
| US08318112B2 |
System and process of light chain hydrocarbon synthesis
The invention relates to a system and process for producing liquid hydrocarbons from a calcium carbonate feed-stock involving (i) liberation of a carbon dioxide gas from the heated calcium carbonate feedstock; (ii) filtering impurities from the extracted carbon dioxide of step (i); (iii) reacting the extracted carbon dioxide obtained in step (i) with a dihydrogen gas to form a methanol feedstock; (iv) isolating the cooled methanol feedstock formed in step (iii); (v) catalytically converting at least part of the methanol feedstock obtained in step (iii) at elevated temperature and pressure into aliphatic and aromatic liquid hydrocarbons; and (vi) isolating the decompressed liquid hydrocarbon product obtained in step (v). |
| US08318111B2 |
Packaging closures integrated with disposable RFID devices
A packaging system (20), has a container (22) which delimits a container volume which can hold at least one unit-measure or unit-quantity of a selected commodity or article (24). The container includes at least one access portion (26) that can provide a selective closed arrangement and a selective open arrangement. An electronic data mechanism (28) can be operatively connected to the container (22), and can be operatively configured to electronically transpond or otherwise transmit data to a reader mechanism (30). A deactivation mechanism (32) can be operatively connected to the container (22) and to the electronic data mechanism (28), and can be operatively configured to selectively disable the electronic data mechanism. |
| US08318110B2 |
Device for the manipulation of limited quantities of liquids
Holding device for the arrangement of at least one optical component in front of a laser light source of a laser unit, including a first holding part to which at least one optical component is attached, the holding device furthermore including a second holding part which is attached to one part of the laser unit, and the first holding part being attached to the second holding part. Furthermore this invention relates to an arrangement with such a holding device and a process for producing this arrangement. |
| US08318109B2 |
Microfluidic devices for fluid manipulation and analysis
The present invention relates to microfluidic devices and methods for manipulating and analyzing fluid samples. The disclosed microfluidic devices utilize a plurality of microfluidic channels, inlets, valves, filter, pumps, liquid barriers and other elements arranged in various configurations to manipulate the flow of a fluid sample in order to prepare such sample for analysis. |
| US08318108B2 |
Suction device
This invention relates to plunger operated liquid dispensers, such as hand held pipettors, which are used to portion liquids. Specifically the invention relates to a reliable removal of a liquid from the liquid dispenser. According to the invention the plunger of the liquid dispenser is arranged into a speeded up movement while removing the liquid. This change in speed is preferably sudden. |
| US08318104B2 |
Waste treatment apparatus and method
An apparatus for treating waste comprises a gravity drop steam heating tower for heating the waste to the biological kill temperature using pressurized steam, a first feed member for feeding the waste to be sterilized to the gravity drop steam heating tower, and a vaporization system. The vaporization system includes a heating chamber for facilitating vaporization of liquids in the waste, a conveying member for conveying the waste from the lower end portion of the gravity drop steam heating tower into and through the heating chamber, and a vaporization chamber for receiving the waste from the heating chamber and for releasing vapor entrained in the waste into the vaporization chamber. |
| US08318103B2 |
Catalytic converter assembly in an exhaust gas posttreatment system
The invention relates to a catalyst arrangement in an exhaust gas after-treatment system of an internal combustion engine comprising an exhaust gas line in which an SCR catalyst is positioned in the direction of flow of the exhaust gas. A reducing agent production system has an NOx and CO/H2 production unit and a combined NOx storage/ammonia production unit in the standard gas-carrying path of the reducing agent production system which supplies ammonia as the reducing agent. The NOx and CO/H2 production unit is at least temporarily supplied via a fuel supply and an air supply with starting products for producing ammonia. The combined NOx storage/ammonia production unit has a plurality catalyst sections having different characteristic properties or functionalities, enabling a higher ammonia yield in the combined NOx storage/ammonia production unit. The catalyst formulations make it possible to adjust a temperature profile that additionally influences the ammonia production rate and contributes to higher ammonia yields. |
| US08318102B2 |
Process for increasing the efficiency of heat removal from a Fischer-Tropsch slurry reactor
The present invention is directed to a cooling system for removing heat from a Fischer-Tropsch (F-T) slurry reactor. The cooling system including at least one downcomer having an upper portion, a lower portion, and a diameter; the at least one downcomer disposed within the F-T reactor to deliver a coolant downward through the F-T reactor at a predetermined velocity, the at least one downcomer extending a length within the F-T reactor wherein the coolant is introduced into the upper portion of the at least one downcomer in a substantially liquid phase; the diameter of the at least one downcomer and the pressure of the introduced coolant cooperate to increase the coolant velocity thereby generating backpressure in the at least one downcomer to maintain the coolant in the substantially liquid phase along the length of the at least one downcomer. The cooling system further including a plenum connected to the lower portion of the at least one downcomer; the plenum in fluid communication with the at least one downcomer wherein the coolant remains in the substantially liquid phase. Additionally, the cooling system includes at least one riser having a length and extending upward from the plenum; the at least one riser in fluid communication with the plenum wherein a portion of the coolant vaporizes to provide a boiling heat transfer surface on the at least one riser. |
| US08318099B2 |
Chemical and biological sensors, systems and methods based on radio frequency identification
Embodiments of the invention include a wireless sensor, such as an RFID tag, that includes a substrate, an antenna disposed on the substrate, and an environmentally sensitive sensor material disposed over at least a portion of said substrate. Other embodiments an RFID tag and at least one antibody coupled to the RFID tag. The RFID tag includes a substrate, circuitry disposed on the substrate, and an antenna coupled to the substrate. The at least one antibody is capable of affecting the signals emanating from the RFID tag. Further embodiments include a detection system that includes a reader. Yet other embodiments include a method for detecting specific analytes. The method includes providing an RFID tag which emanates a first signal having a first frequency, and enabling the REID tag to emanate a second signal having a second frequency upon attraction of a specific analyte to the RFID tag. |
| US08318092B2 |
Oxygenator with integrated arterial filter
An oxygenator combines, in a single structure, a heat exchanger, a gas exchanger and an arterial filter. Such an oxygenator permits fewer fluid connections and thus may simplify an extracorporeal blood circuit, including a heart-lung machine and a blood reservoir, in which it is used. In some cases, the oxygenator may be configured to include multiple purge ports for purging bubbles both before and after filtering the blood. |
| US08318091B2 |
Transfer port and method for transferring sterile items
A sterile enclosure contains a transfer module defining a window. A port covers the window to maintain the inside of the enclosure as a sealed and sterile environment. A sliding, heated cutting element mounted on the port serves to sterilize and sever a portion of a sterile transfer bag assembly attached to the port. Preferably, the excised portion of the sterile transfer bag assembly is affixed to the port when the port opens. The sliding cutting element remains extended and heated to prevent contamination when the port is open. Further, a heating element is mounted about the window in order to sterilize around the opening when the port is open. |
| US08318084B2 |
Method and device for cleaning air
A method and device for cleaning air. The air to be cleaned is directed as a continuous flow in succession through a) a first zone wherein the air is treated with ozone and possibly also water, ammonia or other aerosol growth promoters; b) a second zone wherein the air is subjected to ultraviolet light; c) a third zone wherein the air is maintained for a sufficient time to allow aerosol growth; d) a fourth zone where particles in the air are given an electrical charge; e) a fifth zone wherein the air is passed through an electrostatic filter; and f) a sixth zone wherein the air flows over a catalyst to break down residual ozone. |
| US08318079B2 |
Hydractive recipe
The invention relates to a method for assembling an adhesive device comprising a first matrix-forming material with holes and a second material, the method comprising: (a) compose the first matrix-forming material with holes; (b) compose the second material with a Tm lower than the Tm of the first material, while enabling increase in the Tm of the second material; (c) assemble the adhesive device by filling the holes of the first matrix-forming material of step (a) with the deformable second material of step (b) at a temperature where the second material is deformable and the first material is non-deformable; (d) increase the Tm of the second material. |
| US08318077B2 |
Collection tubes apparatus, systems, and methods
Methods of producing collection tubes are presented. The methods include providing a separator substance that can rapidly polymerize in a short time to a desired hardness and disposing the separator substance within the lumen of the tube. The separator substance is formulated to have a density between an average density of a serum fraction of whole blood and a cell-containing fraction of whole blood, and to be flowable with whole blood. Upon centrifugation of a tube having blood, the separator substance forms a barrier between the whole blood fractions. The barrier rapidly hardens forming a solid barrier when triggered by a suitable energy source. |
| US08318074B2 |
Transfer apparatus having gimbal mechanism and transfer method using the transfer apparatus
A transfer apparatus includes a table on which a molding material is placed, a mold holding body that fixes and holds a mold disposed such as to be opposed to a surface of the table, a gimbal member which holds the mold holding body and which forms a convex spherical surface portion, a gimbal member formed with a concave spherical surface portion which is opposed and in contact with the convex spherical surface portion, a movable body that holds the gimbal member and which can advance and retreat in the vertical direction with respect to the table surface, and an attitude adjusting/holding unit that adjusts and holds attitude of the gimbal member. |
| US08318071B2 |
Method for imparting elasticity to a non-woven material/elastomer laminate
Method for imparting elasticity to a laminate comprising at least one elastic film having a width and at least one ply of non-woven material secured to the film, particularly through interposition of a bonding material, particularly glue, which comprises the following steps in which: the laminate is unrolled in the form of a web in order to pass it between two sets of toothing, of which the teeth engage in each other in a direction perpendicular to the plane of the laminate in order to thus stretch the laminate in the direction of its width, characterized in that: a tension is imparted to the web in the longitudinal direction or machine direction during its unrolling between the toothing, particularly by providing a tensioner roll, particularly downstream of the sets of toothing. |
| US08318070B2 |
Ocular implant made by a double extrusion process
The invention provides biodegradable implants sized for implantation in an ocular region and methods for treating medical conditions of the eye. The implants are formed from a mixture of hydrophilic end and hydrophobic end PLGA, and deliver active agents into an ocular region without a high burst release. |
| US08318066B2 |
Step and repeat imprint lithography process
The present invention is directed to methods for patterning a substrate by imprint lithography. Imprint lithography is a process in which a liquid is dispensed onto a substrate. A template is brought into contact with the liquid and the liquid is cured. The cured liquid includes an imprint of any patterns formed in the template. In one embodiment, the imprint process is designed to imprint only a portion of the substrate. The remainder of the substrate is imprinted by moving the template to a different portion of the template and repeating the imprint lithography process. |
| US08318064B2 |
Method for manufacturing combustible products
This present invention is for an improved method of recycling waste materials consisting substantially of cellulosic fiber and thermoplastic resin to make combustible products useful as industrial fuel with high heat output. The preferred method utilizes a low-speed and high-torque grinder to facilitate the continuous processing of feedstock. One advantage of the present invention over the prior art is the ability to continuously process feedstock while reducing the risk of fire. |
| US08318063B2 |
Injection molding fabrication method
A method of forming a composite article by injecting at least two composite materials comprising metal carbides into a mold to form a green compact is disclosed. The composite materials may be metal powders comprising a binder metal, a hard particle. The composite material may further comprise a plastic binder. The two different composite materials are injected into the mold to form the green compact. Additionally, the composite materials may be injected through a die before entering the mold. In a specific embodiment, the die forms at least one internal channel within the green compact. |
| US08318062B2 |
Industrial absorbents and methods of manufacturing the same
An industrial absorbent and methods of manufacturing the same. In one embodiment, the industrial absorbent includes a first scrim made from at least one thermoplastic material; a second scrim made from at least one thermoplastic material; and a middle layer positioned between the first and second scrims. The middle layer includes a dry-laid web of fire-retardant treated cellulose and opened, individuated staple bicomponent fiber. At least some of the bicomponent fiber in the middle layer is thermally bonded to at least some of the cellulose in the middle layer, and the first and second scrims are thermally bonded to the middle layer. |
| US08318048B2 |
Process for preparing substituted pentacenes
The invention relates to a process of preparing substituted pentacenes, to novel pentacenes prepared by this process, to the use of the novel pentacenes as semiconductors or charge transport materials in optical, electrooptical or electronic devices including field effect transistors (FETs), electroluminescent, photovoltaic and sensor devices, and to FETs and other semiconducting components or materials comprising the novel pentacenes. |
| US08318044B2 |
Light emitting device
A light emitting device is disclosed. The light emitting device may include a light emitting diode (LED) for emitting light and phosphor adjacent to the LED. The phosphor may be excitable by light emitted by the LED and may include a first compound having a host lattice comprising first ions and oxygen. In one embodiment, the host lattice may include silicon, the copper ions may be divalent copper ions and first compound may have an Olivin crystal structure, a β-K2SO4 crystal structure, a trigonal Glaserite (K3Na(SO4)2) or monoclinic Merwinite crystal structure, a tetragonal Ackermanite crystal structure, a tetragonal crystal structure or an orthorhombic crystal structure. In another embodiment, the copper ions do not act as luminescent ions upon excitation with the light emitted by the LED. |
| US08318038B2 |
Nonflammable compositions comprising fluorinated compounds and use of these compositions
The invention relates to non-flammable compositions comprising fluorinated compounds selected from the group consisting of hydrofluoroalkanes, hydrofluoroalkenes, partially or perfluorinated aromatic compounds, hydrofluoroethers or fluoroketones, 1,2-dichloroethylene, especially trans-1,2-dichloroethylene, and a stabilizer. These non-flammable compositions which preferably contain 1,1,1,3,3-pentafluorobutane, can be used especially as solvents for cleaning and defluxing electronic components and for degreasing metals. The compositions further may comprise a propellant, e.g. 1,1,1,2-tetrafluoroethane. These compositions are especially suitable as flushing agent. |
| US08318036B2 |
Sizing composition for an insulating product based on mineral wool, and resulting products
The invention relates to a sizing composition for a thermal and/or acoustic insulation product, based on mineral wool, comprising an epoxy resin of the glycidyl ether type, an amine hardener and an accelerator chosen from imidazoles, imidazolines and mixtures thereof.Application to the manufacture of thermal and/or acoustic insulation products having improved mechanical properties after aging, especially in a wet environment. |
| US08318031B2 |
Method for manufacturing a perpendicular magnetic write head having a tapered write pole
A method for manufacturing a magnetic write head having a write pole with a tapered leading edge and a tapered trailing edge. The method includes forming a non-magnetic bump player over a surface, forming a mask over the non-magnetic bump layer and performing a first ion milling to form a tapered back edge on the non-magnetic bump layer. A magnetic write pole material is then deposited over the surface and over the non-magnetic bump layer. Then a non-magnetic step structure is formed over the magnetic write pole material and an ion milling is performed to form a taper on the upper surface of the write pole. The write pole lateral dimensions can then be defined, and a non-magnetic bump formed over the tapered portion of the upper surface of the write pole. Another ion milling can then be performed to extend the taper of the surface of the write pole. |
| US08318028B2 |
Infiltration/inflow control for membrane bioreactor
A method and system for wastewater treatment comprising a first treatment zone (11) fluidly connected to one or more further treatment zones (12, 13, 14), a membrane module (16) comprising a filter membrane positioned in or fluidly connected to the further treatment zone (14), a gravity settling device (15) fluidly connected to the first treatment zone (11) to receive overflow therefrom; and a flow control device (23) between the first treatment zone (11) and the gravity settling device (15) to control the flow of liquid therebetween. |
| US08318025B2 |
Processing rich ores using magnetic particles
The present invention relates to a process for separating at least one first material from a mixture comprising this at least one first material and at least one second material, which comprises the following steps: (A) contacting of the mixture comprising at least one first material and at least one second material with at least one surface-active substance, if appropriate in the presence of at least one dispersant, resulting in the surface-active substance becoming attached to the at least one first material, (B) if appropriate, addition of at least one dispersant to the mixture obtained in step (A) to give a dispersion having a suitable concentration, (C) treatment of the dispersion from step (A) or (B) with at least one hydrophobic magnetic particle so that the at least one first material to which the at least one surface-active substance is bound and the at least one magnetic particle become attached to one another, (D) separation of the addition product from step (C) from the mixture by application of a magnetic field, (E) cleavage of the addition product which has been separated off in step (D) to obtain the at least one first material and the at least one magnetic particle separately. |
| US08318023B2 |
Heated air assisted membrane separation of water and fuel from engine oil in an internal combustion engine
Contaminating water and/or fuel material may be removed from a stream of internal combustion engine lubricating oil being circulated over parts of an operating engine. A suitable membrane material is supported in a suitable housing. At least a portion of the oil stream is flowed over one side of the membrane and water and/or fuel material diffuses through the membrane to its other side where they are gathered and removed from the housing. The water and fuel material may be recovered separately using different membranes or different regions of a membrane. They may be swept from the membranes and housings using streams of flowing air heated to a pre-selected temperatures using waste engine heat for disposition outside the housing. Application of this practice to other membrane-separable mixtures is described. |
| US08318018B2 |
Methods of extracting neutral lipids and recovering fuel esters
Methods for selective extraction and fractionation of algal lipids and algal products are disclosed. A method of selective removal of products from an algal biomass provides for single and multistep extraction processes which enable efficient separation of algal components. Among these components are neutral lipids synthesized by algae, which are extracted by the methods disclosed herein for the production of renewable fuels. |
| US08318017B2 |
Contaminated inflow treatment with membrane distillation bioreactor
A membrane distillation bioreactor (100) is provided for treating contaminated inflow such as wastewater. A contaminated inflow may be treated by biodegrading a contaminant in the inflow with a biological agent in the bioreactor to produce a lower contaminant inflow, which may be distilled, by membrane distillation, through a distillation membrane (108) in fluid communication with the bioreactor, to produce an outflow. The inflow may be wastewater. The outflow may be purified water. In one embodiment, the membrane may be located in the reaction chamber of the bioreactor vessel (102) and may be submerged in the mixed liquor. In a different embodiment suitable for wastewater treatment, the membrane may be located external to the bioreactor. The bioreactor may be aerobic or anaerobic. |
| US08318005B2 |
Tetra-sulfo iron-phthalocyanine and related methods
The present invention relates to making tetra-sulfo iron-phthalocyanine by reacting sulfonated reactant(s) in the presence a boron-containing promoter. The present invention also relates to making tetra-sulfo iron phthalocyanine more tolerant to oxygen by combining the tetra-sulfo iron-phthalocyanine with a stabilizing amount of a complexing agent (e.g., a stabilizing amine) and/or contacting the tetra-sulfo iron-phthalocyanine with steam. |
| US08318001B2 |
110 neutral base oil with improved properties
We provide a base oil comprising hydrocarbons with consecutive numbers of carbon atoms. The base oil has a boiling range from 700 to 925° F. (371 to 496° C.), a VI from 105 to 119, and either a Noack volatility less than 18 wt % or a CCS VIS at −25° C. less than 1500 mPa·s. The base oil may have a ratio of Noack Volatility to CCS VIS at −25° C. multiplied by 100 from 0.80 to 1.55. |
| US08317998B2 |
Methods of operation of electrochemical gas sensors
A method of operating an electrochemical gas sensor includes: a) exposing, for a first predetermined duration, the electrochemical gas sensor to an atmosphere containing a target gas while the gas reaction capability of the electrode assembly is substantially reduced from a working level, such that target gas is collected within the housing; b) increasing the gas reaction capability of the electrode assembly to a level at which it consumes collected target gas and thereby outputs a signal to the sensing circuit, including an initial transient decay signal; c) monitoring the transient decay signal; and d) analysing the rate of decay of the transient decay signal to determine whether the performance of at least one component of the electrochemical gas sensor is within acceptable limits. An apparatus for operating an electrochemical gas sensor, adapted for connection to an electrochemical gas sensor via a sensing circuit for control thereof, can carry out the disclosed method(s). |
| US08317996B2 |
Auxiliary device, a marine surface vessel and a method for a sacrificial anode in a marine construction
A method is provided for corrosion protection in a marine construction, such as a marine surface vessel or a marine structure, the marine construction including at least one metal element and a sacrificial anode adapted to be at least partly immerged in an electrolyte in the form of water, in which the marine construction is at least partly immerged, the at least one metal element including a metal part, the sacrificial anode being provided for corrosion protection of the metal part. The method includes connecting at least one of the at least one metal element and the sacrificial anode to a DC electrical power outlet so as to allow an electric de-passivation current through an electrical circuit including the sacrificial anode, the metal element and the electrolyte. |
| US08317995B2 |
Electrode tool for electrochemical machining and method of manufacturing the same
Disclosed herein is a highly-durable electrode tool for electrochemical machining, which can prevent the corrosion and abrasion of a conductive pattern at the time of electrochemical machining for forming dynamic pressure-generating grooves of a fluid dynamic bearing, and a method of manufacturing the same. The electrode tool for electrochemical machining includes: an electrode substrate on which a conductive pattern is formed to have protrusions corresponding to the fine grooves and to which negative current is applied; a nonconductive insulating layer, covering an entire top surface of the electrode substrate excluding the conductive pattern; and a conductive layer, which is formed on the conductive pattern to protect the conductive pattern, and a top surface of which is the same height as a top surface of the nonconductive insulating layer. |
| US08317994B2 |
Method of concentrating an aqueous caustic alkali using a catholyte heat recovery evaporator
A method for concentrating an aqueous caustic alkali produced by a membrane cell process by using a single or multiple effect evaporator system in which the vapor flows in a counter direction to the aqueous caustic alkali flow and the heat recovered from the catholyte circulation line is used as part of the concentration process. In one embodiment, a catholyte heat recovery heat exchanger and evaporation chamber are located after the last effect of a multiple effect evaporator system. In another embodiment, the catholyte heat recovery heat exchanger and evaporation chamber are located prior to the single or multiple effect evaporator system. In yet another embodiment, the catholyte heat recovery process is used in conjunction with additional heat exchanger processes to further concentrate the final product as desired. |
| US08317992B2 |
Modular apparatus for a saltwater desalinating system, and method for using same
The present disclosure is directed at a modular apparatus for a saltwater desalinating system, and a method for using same. The apparatus includes multiple internal modules that are compressively coupled to each other. Each of the internal modules includes a pair of rigid end plates located at opposing ends of the internal module, and a stack of membrane bounded compartments that are layered from one of the end plates to the other. The modular apparatus can be used in a membrane based desalination system, which includes concentration difference energy systems, electrodialysis reversal systems, and membrane distillation systems. The modular apparatus helps to mitigate problems such as leakage and buckling in such systems, and can be used to increase membrane packing density and, accordingly, desalination efficiency. |
| US08317991B2 |
Process for electrokinetic migration through liquid membranes
Device and Process for isolating, purifying, concentrating and/or enriching at least one organic compound by electrokinetic migration through liquid membranes by use of an electronic potential and chambers with a preset pH value is described in the present application. The liquid membranes contain an organic solvent capable of transporting an ionized form of said at least one organic compound. |
| US08317986B2 |
High temperature electrolyser with hydrogen recovery device
An electrolyser for generating hydrogen including a plurality of elementary electrolysis cells including a cathode, an anode, and an electrolyte provided between the cathode and the anode. An interconnection plate is interposed between the anode of an elementary cell and a cathode of a following elementary cell, in electric contact with the anode and the cathode, and includes a cathodic compartment, an anodic compartment for circulation of fluid to the cathode and the anode respectively, and a chamber for collecting a gas generated at the cathode, separated from the cathodic compartment and the anodic compartment by first and second walls respectively, the first wall at least having a thickness allowing diffusion of the gas through the first wall from the cathodic compartment to the chamber. |
| US08317981B2 |
Support structure of a coke drum
A support structure of a coke drum including a cylindrical drum body, an inverted-cone-shaped bottom plate connected to a bottom of the drum body, and a cylindrical skirt supporting the drum body includes an annular joining piece joining the drum body, the bottom plate, and the skirt to one another. The joining piece is a unitary member including an upper body part joined to a lower end of the drum body, a lower inner leg part joined to an upper end of the bottom plate, and a lower outer leg part joined to an upper end of the skirt. |
| US08317979B2 |
Papermaking pickup fabric
A papermaking pickup fabric having two ends seamed together with a pintle. The fabric including a first plurality of monofilament yarns directed in a machine direction, a second plurality of monofilament yarns directed in a cross machine direction, and a plurality of multifilament filler yarns. The first plurality of monofilament yarns and the second plurality of monofilament yarns being woven together to form a weave pattern. The plurality of multifilament filler yarns are captivated in the weave pattern. The first plurality of monofilament yarns forming seam loops on each of the ends in a seam loop area, said multifilament filler yarns not extending into said seem loop area. |
| US08317976B2 |
Cut resistant paper and paper articles and method for making same
The specification discloses a method for making a paper material having a reduced tendency to cut human skin. The method includes providing a papermaking furnish containing cellulosic fibers and from about 0.5 to about 5.0 wt % by weight dry basis expandable microspheres, forming a paperboard web from the papermaking furnish, drying the web, and calendaring the web to a caliper of from about 11.0 to about 18.0 mils and a density ranging from about 7.0 to about 12.0 lb/3000 ft2/mil. Papers formed according to the method and articles formed therefrom are also disclosed. |
| US08317974B2 |
Deinking a cellulosic substrate using magnesium hydroxide
A composition and method for deinking is disclosed. The composition and method contain an activated magnesium hydroxide or a magnesium hydroxide. |
| US08317973B2 |
Polyester surfactants for deinking
The present invention relates to cost-effective and environmentally friendly polyester surfactants containing a condensation esterification product of a polyhydric alcohol, a multimeric acid, and at least one polyalkylene glycol for use in flotation deinking under traditional alkaline, reduced alkali, and true neutral deinking conditions. The polyester deinking surfactants of the present invention will effectively exhibit greater selectivity than traditional flotation deinking surfactants. In particular, the polyester deinking surfactants can give better foam control, improved yield, and no loss in ERIC reduction. |
| US08317971B2 |
Plasma processing apparatus and method of manufacturing magnetic recording medium
A plasma processing apparatus includes a discharge window made of a dielectric material, a discharge chamber which is grounded and includes an opening formed at its one end and the discharge window provided at its other end facing the opening, a gas supply system which supplies a gas into the discharge chamber, a high-frequency power application mechanism which applies a high-frequency power to the gas to generate a plasma inside the discharge chamber, a substrate holder which can hold a substrate while facing the discharge window on the outer side of the discharge chamber, a shielding member which partially shields the plasma that impinges on the substrate, and a supporting member which supports the shielding member. The supporting member is grounded and fixed on the shielding member at a position which is farther from the substrate than the shielding member and different from that of the discharge window. |
| US08317969B2 |
Plasma processing apparatus
A plasma processing apparatus includes a processing chamber; a lower center electrode mounting thereon a target substrate; a lower peripheral electrode; an upper electrode disposed above the lower center electrode; a gas supplying unit supplying a processing gas into the processing chamber; a first RF power supply outputting a first RF power for generating a plasma of the processing gas; a second RF power supply for outputting a second RF power for introducing ions into the substrate; and a central feed conductor connected to a rear surface of the lower center electrode. The apparatus further includes a circumferential feed conductor connected to a rear surface of the lower peripheral electrode to bypass and supply some of the first RF power to the lower peripheral electrode; and a movable feed conductor electrically connecting the central feed conductor and the circumferential feed conductor for the first RF power by capacitance coupling. |
| US08317968B2 |
Apparatus including gas distribution member supplying process gas and radio frequency (RF) power for plasma processing
A plasma processing apparatus includes a gas distribution member which supplies a process gas and radio frequency (RF) power to a showerhead electrode. The gas distribution member can include multiple gas passages which supply the same process gas or different process gases at the same or different flow rates to one or more plenums at the backside of the showerhead electrode. The gas distribution member provides a desired process gas distribution to be achieved across a semiconductor substrate processed in a gap between the showerhead electrode and a bottom electrode on which the substrate is supported. |
| US08317967B2 |
Structural urethane adhesives comprising amide polyols
Urethane adhesive compositions comprising amide based polyols. The amide polyols comprise the reaction product of a reactant selected from the group consisting of lactic acid, lactic acid esters, lactone, glycolic acid, glycolic acid esters, and combinations thereof with one or more amines. The urethane adhesive compositions may be applied in methods of manufacturing a tile installation. |
| US08317965B2 |
Method of joining surfaces
The present invention relates to a method of a method of producing a wood-based product, comprising, in the following order: applying an adhesive composition comprising a solvent, onto the first surface only, drying and heating the adhesive composition applied to the first surface, wherein the solvent is partially dried off, and bringing together the first surface with the second surface, and pressing the two surfaces against each other. |
| US08317960B2 |
Process for improving the reflectivity of reflective surfaces of antennas
A process for improving the reflectivity of reflective surfaces made of a composite.The process includes laminating a layer of metalized plastic on at least one layer of composite, bonding the metalized plastic to a substrate in a preimprgenated state; cutting strips or patterns of an assembly of the layer of composite and the layer of metalized plastic; laminating strips or patterns of the assembly as a first layer on a molding jig; adding additional composite layers to the first layer; preparing a vacuum and curing bag; introducing the assembly in an autoclave; performing a curing cycle, bonding the layer of metalized plastic to the rest of the substrate by polymerization of a resin in the composite. |
| US08317957B2 |
Adhesive masking article for corners and door hinges
An adhesive tape masking article that can be used to mask both a door hinge or a corner includes a thin flexible sheet of material having opposed first and second major surfaces, first and second side edges, first and second end edges, and arcuate corners extending between at least one of the first and second side edges and the first and second end edges, and adhesive on at least a portion of at least one of the first and second major surfaces, thereby defining an adhesive surface for adhering the sheet to a surface to be masked. The sheet includes a frangible connection that allows the sheet to be separated into two masking articles, each of which can be used to mask corners. |
| US08317954B2 |
Label affixing system
A label affixing system with which a signal can be supplied to a label affixing machine from an image capturing unit which detects a conveyed object to be labeled. The label affixing system includes a plurality of conveyance lines, a CCD for capturing an image of the conveyed object, and a label affixing machine that includes a plurality of printing formats and affixes a printed label to the conveyed object. The system measures a distance to the conveyed object subjected to image capture by the CCD; selects one printing format from the plurality of printing formats on the basis of the measured distance to the conveyed object; prints the label on the basis of the selected printing format; and affixes the printed label to the conveyed object. |
| US08317952B2 |
High performance electrically controlled solution solid propellant
The present invention is an electrically controlled propellant comprising a binder, an oxidizer, and a cross-linking agent. The boric acid (the cross-linking agent) has been found to function as a cross-linking agent for the high molecular binder used to make the propellant, thereby improving the composition's ability to withstand combustion without melting. The present invention also may include 5-aminotetrazole (5-ATZ) as a stability-enhancing additive. The binder of the present invention may include polyvinylalcohol (PVA) and/or the co-polymer of polyvinylalcohol/polyvinylamine nitrate (PVA/PVAN). |
| US08317951B2 |
Micro gas generator
The micro gas generator employs a liquid propellant, e.g. 50% to 60% by weight hydroxyl ammonium nitrate as an oxidizer, 16% to 22% triethyl ammonium nitrate as fuel, 21% to 28% water as a diluent to provide stability and 1% to 3% additives. The liquid propellant is housed in a can mounted in sealed relation on a retainer in which an initiator is also mounted. |
| US08317941B2 |
R-T-B-type sintered magnet and method for production thereof
An R-T-B based sintered magnet according to the present invention has a composition including: 27.3 mass % to 29.5 mass % of R; 0.92 mass % to 1 mass % of B; 0.05 mass % to 0.3 mass % of Cu; 0.02 mass % to 0.5 mass % of M; and T as the balance, and has an oxygen content of 0.02 mass % to 0.2 mass %. The main phase of the sintered magnet is an R2T14B type compound. The crystal grain size of the main phase is represented by an equivalent circle diameter of 8 μm or less. And crystal grains with equivalent circle diameters of 4 μm or less account for at least 80% of the overall area of the main phase. |
| US08317937B2 |
Alloy for sintered R-T-B-M magnet and method for producing same
In order to make a sintered R-T-B-M magnet so that R2T14B phases that include a lot of Dy in the surface region of the main phase are distributed over the entire magnet, a region including a heavy rare-earth element RH at a high concentration is formed continuously beforehand at an interface between the crystals of an R2T14B compound that is the main phase of the sintered R-T-B-M magnet and the other phases. |