Document Document Title
US08125061B2 Semiconductor package and method of manufacturing the same
A semiconductor package is provided. The semiconductor package includes a carrier, a die, a metal sheet and a molding compound. The die is disposed on the carrier. The metal sheet has a first portion and a second portion, wherein a receiving space is defined by the first portion and the second portion, and the second portion is electrically connected to the carrier. The molding compound covers the die and the receiving space is filled by at least part of the molding compound.
US08125060B2 Electronic component with layered frame
An electronic component is disclosed. In one embodiment, the electronic component includes a frame having a base layer, a first layer, a second layer including palladium placed on the first layer, and a third layer including gold placed on the second layer. A semiconductor chip is positioned on the frame.
US08125058B2 Faraday cage for circuitry using substrates
An apparatus and method uses a first Faraday cage portion and a second Faraday cage portion to provide a Faraday cage enclosure surrounding at least one circuit device. For example, the first Faraday cage portion may include a first conductive portion of a Faraday cage enclosure surrounding the at least one circuit device, and a second Faraday cage portion may include a second conductive portion of the Faraday cage enclosure surrounding the at least one circuit device. Further, for example, the first Faraday cage portion may include a connection surface having one or more conductive contact portions terminating the first conductive portion of the Faraday cage enclosure the second Faraday cage portion may include a connection surface having one or more conductive contact portions terminating the second conductive portion of the Faraday cage enclosure. An electrical connection may be provided between the conductive contact portions of the first and second Faraday cage portions.
US08125056B2 Double trench rectifier
A high power density or low forward voltage rectifier which utilizes at least one trench in both the anode and cathode. The trenches are formed in opposing surfaces of the substrate, to increase the junction surface area per unit surface area of the semiconductor die. This structure allows for increased current loads without increased horizontal die space. The increased current handling capability allows for the rectifier to operate at lower forward voltages. Furthermore, the present structure provides for increased substrate usage by up to 30 percent.
US08125054B2 Semiconductor device having enhanced scribe and method for fabrication
In a semiconductor device for use in a wafer level chip scale package (WLCSP) and a method for fabrication, an inner scribe seal is formed around a functional circuit area that does not extend all the way into the corners of the rectangular die, and an outer scribe seal follows the perimeter of the die and into the corners, with the outer scribe seal having a continuous barrier wall towards the die edges so that moisture penetration in dielectric layers of the die is minimized, and cracks and delamination are stopped near the die edges. Limiting the extent of the insulating layer or layers in the WLCSP to cover the functional circuit area also reduces the stresses caused by these layers near the die corners.
US08125049B2 MIM capacitor structure in FEOL and related method
A capacitor structure includes a semiconductor substrate; a first capacitor plate positioned on the semiconductor substrate, the first capacitor plate including a polysilicon structure having a surrounding spacer; a silicide layer formed in a first portion of an upper surface of the first capacitor plate; a capacitor dielectric layer formed over a second portion of the upper surface of the first capacitor plate and extending laterally beyond the spacer to contact the semiconductor substrate; a contact in an interlayer dielectric (ILD), the contact contacting the silicide layer and a first metal layer over the ILD; and a second capacitor plate over the capacitor dielectric layer, wherein a metal-insulator-metal (MIM) capacitor is formed by the first capacitor plate, the capacitor dielectric layer and the second capacitor plate and a metal-insulator-semiconductor (MIS) capacitor is formed by the second capacitor plate, the capacitor dielectric layer and the semiconductor substrate.
US08125042B2 Semiconductor package and method of manufacturing the same
Provided are a semiconductor package and a method of manufacturing the same. The semiconductor package includes a semiconductor chip, a transparent substrate, an adhesive pattern, and at least one dew-proofer. The semiconductor includes a pixel area. The transparent substrate is disposed on the semiconductor chip. The adhesive pattern is disposed between the semiconductor chip and the transparent substrate and provides a space on the pixel area. At least one dew-proofer is disposed between the semiconductor chip and the transparent substrate and spaced from the adhesive pattern.
US08125041B2 Semiconductor device
A semiconductor device includes: a semiconductor substrate 1; a through electrode 7 extending through the semiconductor substrate 1; a diffusion layer 24 formed in a region of an upper portion of the semiconductor substrate 1 located on a side of the through electrode 7; and a diffusion layer 22 formed in an upper portion of the diffusion layer 24. A portion of the side surface of the through electrode 7 facing the diffusion layer 24 is curved, and a portion of the surface of the diffusion layer 24 facing the through electrode 7 is curved.
US08125040B2 Two mask MTJ integration for STT MRAM
A method for forming a magnetic tunnel junction (MTJ) for magnetic random access memory (MRAM) using two masks includes depositing over an interlevel dielectric layer containing an exposed first interconnect metallization, a first electrode, a fixed magnetization layer, a tunneling barrier layer, a free magnetization layer and a second electrode. An MTJ structure including the tunnel barrier layer, free layer and second electrode is defined above the first interconnect metallization by a first mask. A first passivation layer encapsulates the MTJ structure, leaving the second electrode exposed. A third electrode is deposited in contact with the second electrode. A second mask is used to pattern a larger structure including the third electrode, the first passivation layer, the fixed magnetization layer and the first electrode. A second dielectric passivation layer covers the etched plurality of layers, the first interlevel dielectric layer and the first interconnect metallization.
US08125039B2 One-time programmable, non-volatile field effect devices and methods of making same
One-time programmable, non-volatile field effect devices and methods of making same. Under one embodiment, a one-time-programmable, non-volatile field effect device includes a source, drain and gate with a field-modulatable channel between the source and drain. Each of the source, drain, and gate has a corresponding terminal. An electromechanically-deflectable, nanotube switching element is electrically coupled to one of the source, drain and gate and has an electromechanically-deflectable nanotube element that is positioned to be deflectable in response to electrical stimulation to form a non-volatile closed electrical state between the one of the source, drain and gate and its corresponding terminal.
US08125038B2 Nanolaminates of hafnium oxide and zirconium oxide
A dielectric film containing a HfO2/ZrO2 nanolaminate and a method of fabricating such a dielectric film produce a reliable dielectric layer having an equivalent oxide thickness thinner than attainable using SiO2. A dielectric layer containing a HfO2/ZrO2 nanolaminate may be realized in a wide variety of electronic devices and systems.
US08125037B2 Field effect transistor with channel region edge and center portions having different band structures for suppressed corner leakage
Disclosed are embodiments of field effect transistors (FETs) having suppressed sub-threshold corner leakage, as a function of channel material band-edge modulation. Specifically, the FET channel region is formed with different materials at the edges as compared to the center. Different materials with different band structures and specific locations of those materials are selected in order to effectively raise the threshold voltage (Vt) at the edges of the channel region relative to the Vt at the center of the channel region and, thereby to suppress of sub-threshold corner leakage. Also disclosed are design structures for such FETs and method embodiments for forming such FETs.
US08125034B2 Graded ARC for high NA and immersion lithography
A method of forming a device using a graded anti-reflective coating is provided. One or more amorphous carbon layers are formed on a substrate. An anti-reflective coating (ARC) is formed on the one or more amorphous carbon layers wherein the ARC layer has an absorption coefficient that varies across the thickness of the ARC layer. An energy sensitive resist material is formed on the ARC layer. An image of a pattern is introduced into the layer of energy sensitive resist material by exposing the energy sensitive resist material to patterned radiation. The image of the pattern introduced into the layer of energy sensitive resist material is developed.
US08125031B2 Low on-resistance lateral double-diffused MOS device
A lateral-double diffused MOS device is provided. The device includes: a first well having a first conductive type and a second well having a second conductive type disposed in a substrate and adjacent to each other; a drain and a source regions having the first conductive type disposed in the first and the second wells, respectively; a field oxide layer (FOX) disposed on the first well between the source and the drain regions; a gate conductive layer disposed over the second well between the source and the drain regions extending to the FOX; a gate dielectric layer between the substrate and the gate conductive layer; a doped region having the first conductive type in the first well below a portion of the gate conductive layer and the FOX connecting to the drain region. A channel region is defined in the second well between the doped region and the source region.
US08125026B2 Gate of trench type MOSFET device and method for forming the gate
A gate of a trench type MOSFET device and a method of forming a gate. A gate of a trench type MOSFET device may include a gate oxide film formed on and/or over a trench type gate poly such that parasitic capacitance may be produced in a gate poly. An electric field may be substantially uniformly formed in a MESA region surrounding a gate poly. An overcurrent may be substantially prevented from flowing into a MOS channel around a gate. A gate oxide film may be substantially prevented from being destroyed and/or leakage may be substantially prevented. Reliability of a device may be maximized.
US08125025B2 Semiconductor device
A semiconductor device (such as a MOSFET) can prevent a lowering in the reliability of a gate insulating film and can cope with a finer trench pattern. The MOSFET has a plurality of trenches penetrating a p−-type doped region and a gate electrode formed on the interior surface of each trench with a silicon oxide film (gate insulating film) interposed. The gate electrode is embedded inside the trench such that the upper surface of the former is located above the p−-type doped region, and includes a polysilicon layer facing the p−-type doped region with the silicon oxide film sandwiched therebetween and a low-resistance layer formed on the upper surface of the polysilicon layer and having a lower electrical resistivity than that of the polysilicon layer. An SiN film is formed between the silicon oxide film and the side surface of the low-resistance layer above the p−-type doped region.
US08125022B2 Semiconductor device and method of manufacturing the same
A semiconductor device 1 includes a first semiconductor region 2B and a second semiconductor region 5 provided on a main surface of a substrate 2, being apart from each other and having first conductivity; a third semiconductor region 4 provided between the first semiconductor region 2B and the second semiconductor region 5 and having second conductivity opposite to the first conductivity; a fourth semiconductor region 41 provided on a main surface of the substrate 2, connected to the third semiconductor region 4, manufactured together with the third semiconductor region 4 in the same manufacturing process, and having the conductivity same as that of the third semiconductor region 4; and trenches 42 made on the main surface of the fourth semiconductor region 41 and having a depth smaller than a junction depth of the fourth semiconductor region 41.
US08125018B2 Memory device having trapezoidal bitlines and method of fabricating same
A memory device and a method of fabrication are provided. The memory device includes a semiconductor substrate and a charge trapping dielectric stack disposed over the semiconductor substrate. A gate electrode is disposed over the charge trapping dielectric stack, where the gate electrode electrically defines a channel within a portion of the semiconductor substrate. The memory device includes a pair of bitlines, where the bitlines have a lower portion and a substantially trapezoidal shaped upper portion.
US08125011B2 Vertical cell edge junction magnetoelectronic device family
Magnetoelectronic devices are fabricated by joining the edge of one ferromagnetic thin film element with the top, or bottom, portion of a second ferromagnetic, or nonmagnetic, thin film element. The devices also employ a new operational geometry in which the transport of bias current is in the film plane of at least one of the thin film elements, but is substantially perpendicular to the film plane of at least one of the thin film elements. Additionally, any of the variety magnetoelectronic devices (e.g., current-in-plane spin valves, current-perpendicular-to-the-plane spin valves, magnetic tunnel junctions, and lateral spin valves can be fabricated using these features.
US08125009B2 Mounting circuit substrate
A semiconductor package containing a field effect transistor (FET) used in a high frequency band includes a mounting circuit substrate on which the semiconductor device is mounted. The mounting circuit substrate has a gate wiring conductor, a drain wiring conductor, and a source wiring conductor, which are connected to the gate electrode, the drain electrode, and the source electrode, respectively, of the semiconductor device. The gate wiring conductor and the drain wiring conductor extend toward each other so that their adjacent or facing ends are in close proximity to each other, thereby increasing the capacitance between the gate wiring conductor and the drain wiring conductor.
US08125008B2 Schottky device and process of making the same comprising a geometry gap
A Schottky device and a semiconductor process of making the same are provided. The Schottky device comprises a substrate, a deep well, a Schottky contact, and an Ohmic contact. The substrate is doped with a first type of ions. The deep well is doped with a second type of ions, and formed in the substrate. The Schottky contact contacts a first electrode with the deep well. The Ohmic contact contacts a second electrode with a heavily doped region with the second type of ions in the deep well. Wherein the deep well has a geometry gap with a width formed under the Schottky contact, the first type of ions and the second type of ions are complementary, and the width of the gap adjusts the breakdown voltage.
US08125005B2 Semiconductor element and method for manufacturing same
A semiconductor device includes: a semiconductor layer 10; a semiconductor region 15s of a first conductivity type defined on the surface 10s of the semiconductor layer; a semiconductor region 14s of a second conductivity type defined on the surface 10s of the semiconductor layer to surround the semiconductor region 15s; and a conductor 19 with a conductive surface 19s to contact with the semiconductor regions 15s and 14s. The semiconductor layer 10 includes silicon carbide. At least one of the semiconductor region 15s and the conductive surface 19s is not circular. The semiconductor region 15s and the conductive surface 19s are shaped such that as the degree of misalignment between the conductive surface 19s and the semiconductor region 15s increases from zero through one-third of the width of the conductive surface 19s, a portion of the profile of the conductive surface 19s that crosses the semiconductor region 15s has smoothly changing lengths.
US08125003B2 High-performance one-transistor memory cell
One aspect of this disclosure relates to a memory cell. In various embodiments, the memory cell includes an access transistor having a floating node, and a diode connected between the floating node and a diode reference potential line. The diode includes an anode, a cathode, and an intrinsic region between the anode and the cathode. A charge representative of a memory state of the memory cell is held across the intrinsic region of the diode. In various embodiments, the memory cell is implemented in bulk semiconductor technology. In various embodiments, the memory cell is implemented in semiconductor-on-insulator technology. In various embodiments, the diode is gate-controlled. In various embodiments, the diode is charge enhanced by an intentionally generated charge in a floating body of an SOI access transistor. Various embodiments include laterally-oriented diodes (stacked and planar configurations), and various embodiments include vertically-oriented diodes. Other aspects and embodiments are provided herein.
US08124997B2 Nitride semiconductor light emitting device and method of manufacturing the same
There are provided a method of manufacturing a nitride semiconductor light emitting device and the nitride semiconductor light emitting device manufactured by the method, the method including: forming a light emitting structure by sequentially growing a first conductivity nitride layer, an active layer and a second conductivity type nitride layer on a preliminary substrate for nitride single crystal growth; separating the light emitting structure in accordance with a size of final light emitting device; forming a conductive substrate on the light emitting structure; polishing a bottom surface of the preliminary substrate to reduce a thickness of the preliminary substrate; forming uneven surface structures by machining the preliminary substrate; selectively removing the preliminary substrate to expose portions of the first conductivity type nitride layer; and forming electrodes on the portions of the first conductivity type nitride layer exposed by selectively removing the preliminary substrate.
US08124995B2 Semiconductor light-emitting device
A semiconductor light-emitting device includes a semiconductor light-emitting element emitting light in a region ranging from ultraviolet to visible, and a visible-light luminescent element absorbing light emitted from the semiconductor light-emitting element and outputting visible light. The visible-light luminescent element includes a substrate, a light-reflecting layer formed on the substrate and containing light scattering particles, and a luminescent layer containing phosphor particles. The luminescent layer absorbs light emitted from the semiconductor light-emitting element and output visible light. The luminescent layer further absorbs light that is emitted from the semiconductor light-emitting element, arrives at and is reflected from the light scattering particles, and output the visible light.
US08124982B2 Semiconductor light-emitting element and method for fabrication the same
The semiconductor light-emitting element includes a group III nitride semiconductor multilayer structure having an active layer containing In as well as a p-type layer and an n-type layer stacked to hold the active layer therebetween. The group III nitride semiconductor multilayer structure is made of a group III nitride semiconductor having a major surface defined by a nonpolar plane whose offset angle in a c-axis direction is negative. A remarkable effect is attained when the emission wavelength of the active layer is not less than 450 nm. In the group III nitride semiconductor constituting the group III nitride semiconductor multilayer structure, the offset angle θ in the c-axis direction preferably satisfies −1°<θ<0°.
US08124979B2 Thin film transistor and method of manufacturing the same
Provided are a thin film transistor and a method of manufacturing the same. The thin film transistor includes: a lower structure; a semiconductor layer formed on the lower structure and including a plurality of doping regions; a first insulating layer and a second insulating layer formed on the semiconductor layer and separated from each other; a third insulating layer formed on the first insulating layer and the second insulating layer; and a gate electrode layer formed between regions of the third insulating layer respectively corresponding to the first insulating layer and the second insulating layer.
US08124978B2 Capacitor and method of manufacturing the same
A capacitor and method of manufacturing the same include an insulating interlayer, a lower electrode, a protection structure, a dielectric layer and an upper electrode. The insulating interlayer may include a conductive pattern formed on a substrate. The lower electrode may be electrically connected to the conductive pattern. The protection structure may be formed on an outer sidewall of the cylindrical lower electrode and on the insulating interlayer.
US08124977B2 Localized compressive strained semiconductor
One aspect of the present subject matter relates to a method for forming strained semiconductor film. According to an embodiment of the method, a crystalline semiconductor bridge is formed over a substrate. The bridge has a first portion bonded to the substrate, a second portion bonded to the substrate, and a middle portion between the first and second portions separated from the substrate. The middle portion of the bridge is bonded to the substrate to provide a compressed crystalline semiconductor layer on the substrate. Other aspects are provided herein.
US08124972B2 Thin film transistor
The thin film transistor includes a gate insulating layer covering a gate electrode, over a substrate having an insulating surface; a semiconductor layer forming a channel formation region, in which a plurality of crystal regions is included in an amorphous structure; an impurity semiconductor layer imparting one conductivity type which forms a source region and a drain region; and a buffer layer formed from an amorphous semiconductor, which is located between the semiconductor layer and the impurity semiconductor layer. The thin film transistor includes the crystal region which includes minute crystal grains and inverted conical or inverted pyramidal grain each of which grows approximately radially from a position away from an interface between the gate insulating layer and the semiconductor layer toward a direction in which the semiconductor layer is deposited in a region which does not reach the impurity semiconductor layer.
US08124970B2 Phase change memory device having buried conduction lines directly underneath phase change memory cells and fabrication method thereof
A phase change memory device having buried conduction lines directly underneath phase change memory cells is presented. The phase change memory device includes buried conduction lines buried in a semiconductor substrate and phase change memory cells arranged on top of the buried conductive lines. By having the buried conduction lines directly underneath the phase change memory cells, the resultant device can realize a considerable reduction in size.
US08124968B2 Non-volatile memory device
Provided are a non-volatile memory device which can be extended in a stack structure and thus can be highly integrated, and a method of manufacturing the non-volatile memory device. The non-volatile memory device includes: at least one first electrode, at least one second electrode crossing the at least one first electrode, at least one data storing layer interposed between the at least one first electrode and the second electrode, at a region in which the at least one first electrode crosses the at least one second electrode and at least one metal silicide layer interposed between the at least one first electrode and the at least one second electrode, at the region in which the at least one first electrode crosses the at least one second electrode.
US08124966B2 Anisotropic semiconductor film and method of production thereof
The present invention relates generally to the field of macro- and microelectronics with the potential for large-scale integration, optics, communications, and computer technology and particularly to the materials for these and other related fields. The present invention provides an anisotropic semiconductor film on a substrate, comprising at least one solid layer of material that comprises predominantly planar graphene-like carbon-based structures and possesses anisotropy of conductivity, and wherein the layer thickness is in a range from approximately 5 nm to 1000 nm.
US08124965B2 Opto-electrical devices and methods of making the same
An opto-electrical device comprising: a first electrode for injecting charge carriers of a first polarity; a second electrode for injecting charge carriers of a second polarity; and a layer of organic material disposed between the first and second electrodes, the layer of organic material comprising a blend of a first charge transporting and/or light-emissive polymer and a second charge transporting and/or light-emissive polymer, wherein at least the first polymer is cross-linked providing a first cross-linked matrix in which the second polymer is disposed.
US08124961B2 Single electron transistor
A single electron transistor includes source/drain layers disposed apart on a substrate, at least one nanowire channel connecting the source/drain layers, a plurality of oxide channel areas in the nanowire channel, the oxide channel areas insulating at least one portion of the nanowire channel, a quantum dot in the portion of the nanowire channel insulated by the plurality of oxide channel areas, and a gate electrode surrounding the quantum dot.
US08124943B1 Methods and systems for altering fluorescent intensities of a plurality of particles
A method for altering fluorescent emissions of particles includes setting the particles in motion and exposing the moving particles to light such that fluorescent intensities of the particles are lessened isotropically and substantially simultaneously. Another method includes measuring fluorescent emissions of particles, determining the measured fluorescent emissions do not collectively fit within a first predetermined range of fluorescent values, and exposing the particles to one or more incidents of light that are configured to cooperatively alter the fluorescent emissions of the particles to be within a second predetermined range of fluorescent values. An embodiment of an apparatus includes a vessel configured to contain a plurality of particles and a means for setting the particles in motion. The apparatus further includes an illumination subsystem configured to direct light toward the vessel and at a spectral window (i.e., wavelength or band of wavelengths) which is configured to isotropically and substantially simultaneously lessen the fluorescent emissions of each of the particles.
US08124936B1 Stand-off chemical detector
A stand-off chemical detector has an array of charge-coupled-device electromagnetic radiation sensing elements. One or more first charge-coupled-device electromagnetic radiation sensing elements of the array are selectively responsive to non-visible electromagnetic radiation having at least a first wavelength, and one or more second charge-coupled-device electromagnetic radiation sensing elements of the array are selectively responsive to non-visible electromagnetic radiation having at least a second wavelength that is different that the at least first wavelength.
US08124935B2 Procedure for the detection of ionizing radiation
The present invention relates to a procedure for detection of ionizing radiation and its sources whereby living biosensors are spread-out over a terrain to be examined and which are able by the ionizing radiation to stimulate the production of fluorescent substances whereby their fluorescent radiation is detected from the distance.
US08124934B2 Scanning electron microscope
It is facilitated in a scanning electron microscope to save the labor of executing the reproduction test, conduct basic analysis on a problem caused in execution of the automatic observation process, and confirm details resulting in the error. Upon detecting an error from an abnormality, the scanning electron microscope extracts a sample image lm(t2) obtained by retroceding from a sample image lm(te) stored so as to be associated with time te of error occurrence by a predetermined video quantity (for example, total recording time period t2) previously set and registered by an input-output device, from sample images stored in a recording device while being overwritten, and stores a resultant sample image in another recording device.
US08124933B2 Mapping-projection-type electron beam apparatus for inspecting sample by using electrons emitted from the sample
An apparatus capable of detecting defects of a pattern on a sample with high accuracy and reliability and at a high throughput, and a semiconductor manufacturing method using the same are provided. The electron beam apparatus is a mapping-projection-type electron beam apparatus for observing or evaluating a surface of the sample by irradiating the sample with a primary electron beam and forming on a detector an image of reflected electrons emitted from the sample. An electron impact-type detector such as an electron impact-type CCD or an electron impact-type TDI is used as the detector for detecting the reflected electrons. The reflected electrons are selectively detected from an energy difference between the reflected electrons and secondary electrons emitted from the sample. To eliminate charge-up caused on the sample surface by irradiation with the primary electron beam, the surface of the sample is covered with a cover placed above the sample and a gas is supplied to the space above the sample covered with the cover. The gas is brought into contact with the sample surface to reduce charge-up on the sample surface.
US08124932B2 Charged particle beam apparatus and method adjusting axis of aperture
A charged particle beam apparatus includes a charged particle source, an aperture, an object lens, an observing unit, an aperture driving portion, and a control portion. The control portion includes a spot pattern forming portion that forms a plurality of spot patterns on a surface of a sample by irradiating a charged particle beam, an analyzing portion that calculates a position of a spot center of the spot pattern and a geometrical center position of a halo, and an adjusting position determining portion that calculates an adjusting position based on a position of intersecting lines connecting the positions of the spot centers of the respective spot patterns and the center position of the halo. In this manner, the position of the aperture can be easily and accurately adjusted in a short period of time by moving the center axis of the aperture to the adjusting position.
US08124927B2 Detecting light in whispering-gallery-mode resonators
An optical device including a whispering gallery mode (WGM) optical resonator configured to support one or more whispering gallery modes; and a photodetector optically coupled to an exterior surface of the optical resonator to receive evanescent light from the optical resonator to detect light inside the optical resonator.
US08124924B2 Photoelectric conversion device and electronic device provided with the photoelectric conversion device
An output terminal of a photoelectric conversion element included in the photoelectric conversion device is connected to a drain terminal and a gate terminal of a MOS transistor which is diode-connected, and a voltage Vout generated at the gate terminal of the MOS transistor is detected in accordance with a current Ip which is generated at the photoelectric conversion element. The voltage Vout generated at the gate terminal of the MOS transistor can be directly detected, so that the range of output can be widened than a method in which an output voltage is converted into a current by connecting a load resistor, and so on.
US08124923B2 Wireless remote detector systems and methods
A system for an embodiment includes a sensor device having at least one sensor adapted to monitor at least one parameter associated with a circuit and selectively provide measurement information on the at least one parameter. The at least one sensor may include an electrical sensor adapted to monitor an electrical parameter of the circuit for the sensor device to selectively provide as the measurement information, and wherein the sensor device includes a wireless transceiver within the sensor device and is adapted to transmit the measurement information and receive control information. The system may further include a receiver indicator device having a wireless transceiver and adapted to wirelessly receive the measurement information from the sensor device, provide the control information to the sensor device, and provide an indication based on the measurement information to a user operating the receiver indicator device.
US08124922B2 Photoelectric conversion device including photoelectric conversion element and amplifier circuit having a thin film transistor
Objects are to accumulate electric charge in a capacitor so that light intensity can be detected even when the amount of incident light is small, and to operate a photoelectric conversion device without increasing the number of elements such as a constant current source or a switch. The photoelectric conversion device includes a photoelectric conversion circuit, a capacitor, and a comparator for comparing a potential of one electrode of the capacitor with a second potential. The photoelectric conversion circuit includes a photoelectric conversion element and an amplifier circuit for amplifying an output current from the photoelectric conversion element In the capacitor, a first potential is supplied through a first switch, and charging or discharging is performed through a second switch in accordance with the current amplified by the amplifier circuit.
US08124917B2 Accurate temperature measurement in household kettles
A vessel for preparing heated water or other liquid includes a container, an electric heater and a temperature sensing probe mounted through a wall of the container. The probe includes an efficient heat transferring structure in direct thermal contact with and wet by the liquid. An electrical sensor within the probe is in intimate thermal contact with the transferring structure and has electrical properties directly correlating with the temperature of the transferring structure. The transferring structure is attached to a supporting structure mounted to the wall by an elastomeric efficient thermal insulating material held in compression providing physical support for the probe and sealing the wall from leaking and insuring that the sensor is primarily thermally responsive to the temperature of the transferring surface and to the liquid but is thermally insulated from variations in the temperature of the supporting wall.
US08124914B2 Hair iron with dimpled face plates and method of use in styling hair
An iron for styling hair containing opposed plates having confronting surfaces for clamping a section of hair therebetween wherein surface one or both of the plates, is formed with a plurality of depressions, e.g., dimples, distributed over its surface. The depressions are of sizes that decrease from opposite outer edges of the plate toward the centerline of the plate. At least one of the plates is heated to a temperature in the range of 380° to 450° F. whereby heat can be applied to the section of hair while clamped between the plates. The plates are preferably formed of zeolite and coated with tourmaline. The hair iron is used to facilitate coloring of hair in which coloring is applied to the hair following which the hair is rinsed and is wet, in which the hair iron is used on the wet hair so as to dry the hair, in lieu of a hair dryer, thereby putting an end to all reactions in the coloring process.
US08124911B2 On-the-fly manipulation of spot size and cutting speed for real-time control of trench depth and width in laser operations
Systems and methods cut trenches of multiple widths in a material using a single pass of a laser beam. A first series of laser pulses cut a work surface of the material at a first cutting speed using a first spot size. In a transition region from a first trench width to a second trench width, a second series of laser pulses sequentially change spot sizes while gradually changing from the first cutting speed to a second cutting speed. Then, a third series of laser pulses continue to cut the work surface at the second cutting speed using a second spot size. The method provides for increased depth control in the transition region. A system uses a selectively adjustable optical component in the laser beam path to rapidly change spot size by adjusting a position of a focal plane with respect to the work surface.
US08124909B2 Laser processing apparatus
A laser processing apparatus including a height detecting device for detecting the height of a workpiece held on a chuck table. The height detecting device includes an annular spot forming unit for forming the spot shape of a detecting laser beam into an annular spot shape, a pinhole mask for passing the reflected light reflected on the upper surface of the workpiece held on the chuck table, but blocking the reflected light reflected on the lower surface of the workpiece, and a reflected light analyzing unit for analyzing the reflected light passed through the pinhole mask and transmitting the result of analyzation to a control unit. The laser processing apparatus further includes a focusing unit having an objective lens for focusing a processing laser beam having a circular spot shape and the detecting laser beam having the annular spot shape and a window lens for focusing the detecting laser beam focused by the objective lens without focusing the processing laser beam.
US08124908B2 Laser welding method, laser-welded joint, outside sheathing panel, and body structure for rolling stock
A side construction 302 has an outside sheathing 306 and outside sheathing reinforcement members 307A and 307B joined to the outside sheathing 306 interiorly of the outside sheathing 306. The reinforcement member 307A (307B) is shaped like a hat in section. The reinforcement members 307A provided in the vicinity of a window opening portion have a laser welding spacing L1 of 80 mm and each have a hat width of 50 mm, while the reinforcement members 307B provided on other part have a laser welding spacing L1 of 100 mm and each have a hat width of 70 mm. The reinforcement members 307A and 307B each have a height of 25 mm.
US08124903B2 Input device and manufacturing method thereof
An input device for constructing an inputting operation unit for various electronic apparatus and a method of manufacturing the input device are provided. The input device allows push-down inputting operation and position inputting operation using the same operating unit. The input device has a position input sensor provided under a key, and a base sheet having a movable contact joined to its bottom face depending on the location where the key is disposed, and a columnar section is disposed in a manner sandwiched between the position input sensor and the base sheet at the center of the movable contact.
US08124902B2 Push button switch
A push button switch includes a base part (22) provided with a snap dome (23b) and a fixed contact (23a), a cover member (24) disposed to cover the base part (22) and having at one side surface an opening (42), an operating controller (25) disposed to slide inside the opening (42) in a lateral direction and configured to press the snap dome (23b) downwardly. The cover member (24) includes side extended potions (36) provided to extend downwardly from the cover member (24) along side surfaces of the base part across the operating controller (25) in a direction perpendicular to a sliding direction of the operating controller (25). Lower end portions of the side plate portions (36) are provided with extensions (38) disposed adjacent to some of the solder pad portions (41) provided on a lower surface of the base part (22).
US08124901B2 Energy storage mechanism for switching device
There is obtained an energy storage mechanism, for a switching device, that has a structure requiring no high-accuracy components and can perform release of driving-power transmission and re-engagement. In the case where the closing spring 22 is energized, the main gear 5 is rotated by the energy storage motor 3 or manually, via the output gear 16 and the intermediate gear 33; in the case where the closing spring 22 has been energized, the engagement between the intermediate gear 33 and the main gear 5 is released at a missing-tooth portion 34 of a gear B; in the case where the switching device is closed, the main gear 5 is rotated by restoration force exerted by the closing spring 22, and the intermediate gear 33 is separated from the main gear 5 due to the elongated hole 35 that supports the rotation axle 25 thereof; and in the case where the closing spring 22 is energized again, the intermediate gear 33 is again engaged with the main gear 5 due to the elongated hole 35 that supports the rotation axle 25 thereof.
US08124898B2 Electrical device controller having a switch and a thumbwheel dimmer
An electrical device controller is provided for controlling power to a load. The controller includes a housing having an open face and a plate having a unitary aperture secured to the housing and disposed over the open face. The controller further includes an electrical power controller component positioned within the housing for coupling to a power source and a load, a first actuator coupled to the electrical component, and an adjacent second actuator coupled to the electrical component. The first actuator has a movable user operable portion that is user accessible via the unitary aperture for controlling power ON/OFF to the load. The second actuator has a movable user operable portion that is user accessible via the unitary aperture for adjusting magnitude of power delivered to the load. The movement and position of the respective user operable portions of the first and second actuators are mutually independent.
US08124896B2 Sliding contact switch
An electrical sliding contact switch having a housing in which a common contact body and at least one selective contact body having a contact surface are arranged. A sliding area including electrically insulating material is arranged adjacent to the contact area of the selective contact body. A contactor that is in continuous electrically conducting connection with the common contact body and has at least one sliding contact is either in electrically conducting connection with the selective contact body or touches the sliding area. An actuating member is furthermore arranged in the housing such that upon actuation, it slidingly moves the at least one sliding contact of the contactor on a sliding path from the contact surface of the selective contact body into the sliding area and/or out of the sliding area to the contact surface of the selective contact body. Furthermore, embodied in the sliding path, are zones that are not touched by the sliding contacts during transit of the sliding area.
US08124895B2 Planar microelectromechanical device having a stopper structure for out-of-plane movements
A microelectromechanical device has a mobile mass that undergoes a movement, in particular a spurious movement, in a first direction in response to an external event; the device moreover has a stopper structure configured so as to stop said spurious movement. In particular, a stopper element is fixedly coupled to the mobile mass and is configured so as to abut against a stopper mass in response to the spurious movement, thereby stopping it. In detail, the stopper element is arranged on the opposite side of the stopper mass with respect to a direction of the spurious movement, protrudes from the space occupied by the mobile mass and extends in the space occupied by the stopper mass, in the first direction.
US08124889B2 Electronic device with opening/closing door
An electronic device with an opening/closing door according to the present invention includes a device body in which an opening is defined, and a shutter system capable of covering and exposing the opening. The shutter system includes a door for covering the opening, an arm, a driving member for driving the arm, and a mounting table having a front surface and a rear surface. The arm and the driving member are arranged on the front surface, and the door is arranged on the rear surface. The door is capable of sliding along the rear surface of the mounting table. The arm has a root end and a front end. The root end is pivotably supported on the front surface of the mounting table at a position closer to one side edge portion of the door than a center line of the width of the door. The front end engages with the other side edge portion of the door without holding the mounting table therebetween.
US08124884B2 Printed circuit board
A printed circuit board (PCB) includes a positive differential signal line including first and second segments, a negative differential signal line including third and fourth segments, first and second connecting elements soldered on opposite surfaces of the PCB. The first segment and the fourth segment are located in a first straight line which has a first permittivity. The third segment and the second segment are located in a second straight line which has a second permittivity different from the first permittivity. The first connecting element is connected between the first segment and the second segment. The second connecting element is connected between the third segment and the fourth segment.
US08124883B2 Ceramic multilayer substrate and method for manufacturing the same
In a method for manufacturing a ceramic multilayer substrate, when a green ceramic stack prepared by stacking a plurality of ceramic green sheets is fired simultaneously with a ceramic chip electronic component disposed inside the green ceramic stack and including an external terminal electrode to produce a ceramic multilayer substrate having the ceramic chip electronic component inside, a paste layer is disposed in advance between the ceramic chip electronic component and the green ceramic stack, and these three are fired.
US08124881B2 Printed board and portable electronic device which uses this printed board
A printed board comprising a packaging surface on which an electronic component is packaged, an adhesion prohibited portion which is provided at a region of the printed board different from a region where the electronic component is provided, and to which adhesion of the adhesive material is prohibited, and a blocking step portion which is formed at a region between the region where the electronic component is provided and the region where the adhesion prohibited portion is provided, which blocks any adhesive material which has spilled out from between the bottom surface of the electronic component and the packaging surface from reaching the adhesion prohibited portion.
US08124880B2 Circuit board and method for manufacturing thereof
A method of manufacturing a circuit board that includes: forming a conductive relievo pattern, including a first plating layer, a first metal layer, and a second plating layer stacked sequentially in correspondence with a first circuit pattern, on a seed layer stacked on a carrier; stacking and pressing together the carrier and an insulator, such that a surface of the carrier having the conductive relievo pattern faces the insulator; transcribing the conductive relievo pattern into the insulator by removing the carrier; forming a conduction pattern, including a third plating layer and a second metal layer stacked sequentially in correspondence with a second circuit pattern, on the surface of the insulator having the conductive relievo pattern transcribed; removing the first plating layer and seed layer; and removing the first and second metal layers, can provide a circuit board that has high-density circuit patterns without an increased amount of insulator.
US08124877B2 Semiconductive polymer composition
The invention relates to a semiconductive polymer composition for use in power cables. The composition comprises a multimodal ethylene homo- or copolymer produced in a polymerization process comprising a single site catalyst whereby the polymer composition has a density of 870 to 930 kg/m3, a MFR2 of 1 to 30 g/10 min and a Mw/Mn of less than or equal to 10.
US08124871B2 Solar cell and its transparent light conversion film
The present invention discloses a solar cell which can enhance the absorption of the short-wavelength range radiation λ<400 nm of the sun and re-radiate in the wavelength range λ=500˜780 nm to enhance the solar cell's capability in absorbing more long-wavelength radiation and form separate electron-hole pairs so as to increase the output power of the solar cell assembly. Furthermore, the present invention also provides a transparent light conversion film for solar cells.
US08124865B2 Method of fabrication of plastic film supported single crystal silicon photovoltaic cell structure
A method of fabricating a wafer-size photovoltaic cell module includes defining an integrated cellular structure of a light converting monolateral or bilateral junction diode in an epitaxially grown detachable layer including a first deposited metal current collecting terminal of the diode. The method also includes laminating onto the surface of the processed epitaxially grown detachable layer a film of an optical grade plastic material resistant to hydrofluoric acid solutions. The method further includes immersing the wafer in a hydrofluoric acid solution causing detachment of the epitaxially grown silicon layer laminated with the film, and polishing the surface of separation of the detached epitaxially grown layer and forming a second metal current collecting terminal of the diode by masked deposition of a metal at a temperature tolerable by the film.
US08124859B2 Plants and seeds of hybrid corn variety CH845645
According to the invention, there is provided seed and plants of the hybrid corn variety designated CH845645. The invention thus relates to the plants, seeds and tissue cultures of the variety CH845645, and to methods for producing a corn plant produced by crossing a corn plant of variety CH845645 with itself or with another corn plant, such as a plant of another variety. The invention further relates to genetic complements of plants of variety CH845645.
US08124854B2 Plants and seeds of hybrid corn variety CH892646
According to the invention, there is provided seed and plants of the hybrid corn variety designated CH892646. The invention thus relates to the plants, seeds and tissue cultures of the variety CH892646, and to methods for producing a corn plant produced by crossing a corn plant of variety CH892646 with itself or with another corn plant, such as a plant of another variety. The invention further relates to genetic complements of plants of variety CH892646.
US08124853B2 Plants and seeds of hybrid corn variety CH897363
According to the invention, there is provided seed and plants of the hybrid corn variety designated CH897363. The invention thus relates to the plants, seeds and tissue cultures of the variety CH897363, and to methods for producing a corn plant produced by crossing a corn plant of variety CH897363 with itself or with another corn plant, such as a plant of another variety. The invention further relates to genetic complements of plants of variety CH897363.
US08124851B2 Alteration of tobacco alkaloid content through modification of specific cytochrome P450 genes
Compositions and methods for reducing the level of nornicotine and N′-nitrosonornicotine (NNN) in Nicotiana plants and plant parts thereof are provided. The compositions comprise isolated polynucleotides and polypeptides for cytochrome P450s that are involved in the metabolic conversion of nicotine to nornicotine in these plants. Expression cassettes, vectors, plants, and plant parts thereof comprising inhibitory sequences that target expression or function of the disclosed cytochrome P450 polypeptides are also provided. Methods for the use of these novel sequences to inhibit expression or function of cytochrome P450 polypeptides involved in this metabolic conversion are also provided. The methods find use in the production of tobacco products that have reduced levels of nornicotine and its carcinogenic metabolite, NNN, and thus reduced carcinogenic potential for individuals consuming these tobacco products or exposed to secondary smoke derived from these products.
US08124850B1 Soybean variety XB29AJ09
According to the invention, there is provided a novel soybean variety designated XB29AJ09. This invention thus relates to the seeds of soybean variety XB29AJ09, to the plants of soybean XB29AJ09 to plant parts of soybean variety XB29AJ09 and to methods for producing a soybean plant produced by crossing plants of the soybean variety XB29AJ09 with another soybean plant, using XB29AJ09 as either the male or the female parent.
US08124849B2 Squash line YPC 130-1035T
The invention provides seed and plants of the squash line designated YPC 130-1035T. The invention thus relates to the plants, seeds and tissue cultures of squash line YPC 130-1035T, and to methods for producing a squash plant produced by crossing a plant of squash line YPC 130-1035T with itself or with another squash plant, such as a plant of another line. The invention further relates to seeds and plants produced by such crossing. The invention further relates to parts of a plant of squash line YPC 130-1035T, including the fruit and gametes of such plants.
US08124843B2 Methods and genetic compositions to limit outcrossing and undesired gene flow in crop plants
The present invention relates to methods to control the spread of recombinant DNA molecules between sexually compatible plants of differing genetic composition. The invention describes the production of transgenic plants that comprise recombinant traits of interest or concern linked to repressible lethal genes. The lethal genes are blocked by the action of repressor molecules produced by the expression of repressor genes located at a different genetic locus. The lethal phenotype is only expressed after the segregation of the repressible lethal gene construct and the repressor gene following meiosis. The present invention may be employed for both open-pollinated and hybrid seed production systems and may be used to maintain genetic purity by blocking unintended introgression of genes from plants devoid of the specific repressor gene. The invention includes methods that impart traits that are desirable for environmentally responsible heterologous protein production, to genetic material used to impart said traits and to new plants and products derived by said methods.
US08124841B2 Truncation of the C-terminal end of alpha-amylase
The present invention is directed to C-terminal truncated α-amylase polypeptides, nucleic acid sequences encoding the truncated α-amylase polypeptides, and methods of using the same. Further provided are expression cassettes, plants and plant parts expressing the nucleic acid sequence encoding the truncated α-amylase. Expression of the truncated α-amylase in a plant cell results in enhanced accumulation of biologically-active α-amylase, or enhanced secretion of the α-amylase from the plant cell, compared to the accumulation or secretion of a full length α-amylase.
US08124840B2 Regulating metabolism by modifying the level of trehalose-6-phosphate
Method for the inhibition of carbon flow in the glycolytic direction in a cell by increasing the intracellular availability of trehalose-6-phosphate.
US08124839B2 Identification of terpenoid-biosynthesis related regulatory protein-regulatory region associations
Materials and methods for identifying terpenoid regulatory region-regulatory protein associations are disclosed. Materials and methods for modulating expression of a sequence interest are also disclosed.
US08124832B2 Method for producing cloned dog
Provided is a method for producing a cloned dog by enucleating an oocyte of a dog to produce an enucleated oocyte, transferring a somatic cell of the dog into the enucleated oocyte, carrying out electrofusion under optimized conditions to produce a nuclear transfer embryo, and transferring the nuclear transfer embryo into its surrogate mother.
US08124820B2 Process for the manufacture of polyolefins
The present invention relates to a process for producing polyolefins wherein a feedstock comprising n-olefin or a mixture of n-olefins is dimerized in the presence of a solid acidic catalyst by passing the feedstock to a catalytic distillation apparatus comprising either a) a combination of a distillation column and a reactor comprising at least one catalyst bed, or b) a distillation column connected to one or more side reactors comprising at least one catalyst layer, recovering the unreacted n-olefin from the distillation column or the combination of the distillation column and the reactor at the upper part thereof as a side-stream to be combined with the feedstock, and the reaction product from the dimerization is hydrogenated.
US08124816B2 Hydrogenation of esters with Ru/tetradentate ligands complexes
The present invention relates to the field of catalytic hydrogenation and, more particularly, to the use of Ru complexes with tetradentate ligands having at least one amino or imino coordinating group and at least one phosphino coordinating group in hydrogenation processes for the reduction of esters or lactones into the corresponding alcohol or diol respectively.
US08124813B2 Method of producing 2-phenoxyacetals and the corresponding 2-phenoxy-carbaldehydes therefrom
The invention relates to a novel process for preparing 2-phenoxyacetals and the corresponding 2-phenoxycarbaldehydes. These compounds are important intermediates for the preparation of active pharmaceutical ingredients.
US08124806B2 Contrast agents
The present invention relates to a class of compounds and to diagnostic compositions containing such compounds where the compounds are iodine containing compounds. More specifically the iodine containing compounds are chemical compounds containing an aliphatic central moiety containing amide functions allowing for the arrangement of three iodinated phenyl groups bound thereto. The invention also relates to the use of such diagnostic compositions as contrast agents in diagnostic imaging and in particular in X-ray imaging and to contrast media containing such compounds.
US08124801B2 Process of manufacturing of fatty acid alkyl esters
Processes for preparation of fatty acid alkyl esters are described herein. The processes include contacting fatty acid glycerides with alcohols in the presence of a catalyst separating the reaction products from the catalyst, and separating the fatty acid alkyl esters from the reaction products. The catalyst includes a metal from Group VIB of the Periodic Table and an element from Group VA of the Periodic Table.
US08124798B2 Direct epoxidation catalyst and process
A catalyst, useful for the direct epoxidation of olefins, is disclosed. The catalyst comprises palladium nanoparticles, support nanoparticles, and a titanium zeolite having a particle size of 2 microns or greater. The palladium nanoparticles are deposited on the support nanoparticles to form supported palladium nanoparticles, and the supported palladium nanoparticles are deposited on the titanium zeolite; or the supported palladium nanoparticles are deposited on a carrier having a particle size of 2 microns or greater. The invention also includes a process for producing an epoxide comprising reacting an olefin, hydrogen and oxygen in the presence of the catalyst. The catalysts are more active in epoxidation reactions, while demonstrating the same or better selectivity.
US08124796B2 Method for preparing 3-hydroxytetrahydrofuran using cyclodehydration
Disclosed is a method of preparing 3-hydroxytetrahydrofuran using cyclodehydration. More particularly, this invention relates to a method of preparing 3-hydroxytetrahydrofuran, including subjecting 1,2,4-butanetriol to cyclodehydration under reaction conditions of a reaction temperature of 30˜180° C. and reaction pressure of 5000 psig or less in the presence of a strong acid cation exchange resin catalyst having a sulfonic acid group as an exchange group. According to the method of this invention, 3-hydroxytetrahydrofuran can be economically prepared at higher yield and productivity than when using conventional methods.
US08124791B2 Active energy ray curable liquid composition and liquid cartridge
The invention provides an active energy ray curable liquid composition containing a compound represented by a general formula (I): wherein A is a hydrogen atom or a monovalent organic residue which may be substituted, R1 and R2 are, independently of each other, a divalent organic group which may be substituted, E is an amide bond, Rn is a cyclic linking group having a carbonyl group and an unsaturated carbon-carbon bond adjacent to the carbon atom of the carbonyl group, m is a number of 0 or greater, n is a number of 2 or greater, m+n is 3, and Z is a secondary or tertiary amino bond structure, with the proviso that the amino bond may be a salt of a secondary or tertiary amine, and a liquid cartridge.
US08124787B2 Process for the production of pyrazoles
A process for the production of a compound of formula (I), which comprises a) reacting a compound of formula (II), wherein R1 and R2 are both independently C1-C6 alkyl, with methylhydrazine in the presence of water and a water-immiscible organic solvent being inert in saponification reactions, to form a compound of formula (III) wherein R1 is as defined for formula (II) and b) saponifying that compound in situ leading to the formation of the compound of formula (I) by b1) adding a base to form the anion of the compound of formula (I) and then adding an; acid to form the compound of formula (I); or b2) adding an acid to form the compound of formula (I).
US08124784B2 Palladium metal complex
Disclosed is a metal complex containing a composition represented by the following formula (a). [(PdII)2(MI)2(X)2(L)4(L′)2] (In the formula (a), MI represents AgI, AuI or CuI; X represents Cl, Br or I; L represents a group represented by formula (1); L′ represents a group represented by formula (2); two MIs may be the same as or different from each other; four Ls may be the same as or different from each other; and two L's may be the same as or different from each other.) (In the formulae (1) and (2), R1, R2 and R3 independently represent a hydrogen atom, a halogen atom, a hydroxy group, an optionally substituted alkyl group, an optionally substituted aryl group or an optionally substituted monovalent heterocyclic group.)
US08124780B2 Benzimidazole compound
A novel chemical compound useful as a therapeutic or prophylactic agent for acid-related diseases is provided, which has an excellent inhibitory effect against gastric acid secretion, an excellent effect of maintaining the inhibitory effect against gastric acid secretion, thereby maintaining intragastric pH high for a long time, and having more safety and appropriate physicochemical stability. Provided is a compound represented by where R1 and R3 may be the same or different and each represent a hydrogen atom or a C1-C6 alkyl group; R2 represents (5,5-dimethyl-1,3-dioxan-2-yl)methoxy group, 5,7-dioxaspiro[2.5]oct-6-ylmethoxy group, 1,5,9-trioxaspiro[5.5]undec-3-ylmethoxy group, or (2,2-dimethyl-1,3-dioxan-5-yl)methoxy group; R4, R5, R6 and R7 represent a hydrogen atom, halogen atom, C1-C6 alkyl group, C1-C6 haloalkyl group, C1-C6 alkoxy group or C1-C6 haloalkoxy group; and W1 represents a single bond, methylene or ethylene group, a salt thereof or a solvate of these.
US08124776B2 Process and intermediates for preparing arzoxifene
The present invention provides for novel compounds of formula I wherein X is S or S(O); R1 and R2 are each independently selected from the group consisting of —CH2CH3 and phenyl; or R1 and R2 combine to form morpholino; and processes to prepare arzoxifene.
US08124772B2 Intermediate products for producing oxazolidinone-quinolone hybrids
The present invention describes intermediates (ZP) for a novel and efficient synthesis of compounds in which the pharmacophores of quinolone and oxazolidinone are linked to one another by way of a chemically stable linker.
US08124771B2 Pyridine classical cannabinoid compounds and related methods of use
Disclosed are compounds of the formula I: wherein R1, R2, V, W, X, Y and Z can be as defined herein. The compounds can be used in the treatment of disorders mediated by the cannabinoid receptors.
US08124767B2 Luminescence biotin-transition metal complex conjugate, and method of amplifying signal using the same
Disclosed are a luminescence biotin-transition metal complex conjugate and a method of amplifying signals using the same. More particularly, disclosed herein are a luminescence biotin-transition metal complex conjugate comprising an energy acceptor and biotin, and optionally an energy donor and a method of amplifying signals using the biotin-transition metal complex conjugate using intramolecular energy transfer. The luminescence biotin-transition metal complex conjugate using a transition metal probe provides a phosphorescence detection system capable of improved sensitivity.
US08124762B2 Diphenyl amine derivatives having luminescence property
The present invention relates to diphenyl amine derivatives having luminescent properties, and particularly to diphenyl amines substituted with various electron-donating or electron-withdrawing groups. The compounds of the present invention show blue or blue-green luminescence, and luminescence of the compounds herein can be achieved by UV or visible light, thus being useful as a fluorescent dye or fluorescent material for an organic electroluminescence device or display.
US08124760B2 Pyridyl-triazolopyrimidine derivative or its salt, pesticide containing it and its production process
To provide a novel pesticide. The present invention provides a pesticide containing a pyridyl-triazolopyrimidine derivative represented by the formula (I) or its salt as an active ingredient: wherein R1 is substitutable alkyl, substitutable cycloalkyl, substitutable alkenyl, substitutable alkynyl, halogen, cyano, aryl, a heterocyclic group which may be substituted by alkyl, OR2, S(O)n#191R3? or NR4R5; R2 is hydrogen, alkyl, alkenyl, alkynyl, haloalkyl, alkoxyalkyl, acetyl or aryl; R3 is alkyl or acetyl; R4 is hydrogen or alkyl; R5 is hydrogen, alkyl or the like; X is alkyl, alkenyl, alkynyl, halogen, haloalkyl, cyano, nitro or the like; m is an integer of from 1 to 4; and n is an integer of from 0 to 2.
US08124759B2 Inhibitors of protein kinases
Compounds that inhibit Aurora-kinases, compositions containing the compounds and methods of treating diseases using the compounds are disclosed.
US08124758B2 Process for the preparation of N-Acetyl-D-mannosamine monohydrate
A process is described for the preparation of N-Acetyl-D-mannosamine monohydrate of formula (I) a specific intermediate in the synthesis of N-Acetyl-neuraminic acid, that is an important starting product for the synthesis of various pharmaceutically active products.
US08124753B2 Compositions and methods for inhibiting translation of a Mect1-MAML2 chimeric gene
Composition for the inhibition of the translation of a Mect1-MAML2 chimeric gene consisting essentially of: (a) a fragment of the nucleic acid encoding the chimeric gene, and (b) a nucleic acid complementary to the fragment, and a method of inhibiting the translation of a Mect1-MAML2 chimeric gene comprising contacting a cell expressing the chimeric gene with the composition, whereupon the translation of the chimeric gene is inhibited.
US08124751B2 Hybridization chain reaction amplification for in situ imaging
The present invention relates to the use of fluorescently labeled nucleic acid probes to identify and image analytes in a biological sample. In the preferred embodiments, a probe is provided that comprises a target region able to specifically bind an analyte of interest and an initiator region that is able to initiate polymerization of nucleic acid monomers. After contacting a sample with the probe, labeled monomers are provided that form a tethered polymer. Triggered probes and self-quenching monomers can be used to provide active background suppression.
US08124742B2 Rh(D)-binding proteins
The invention includes Rh(D) binding proteins, including antibodies, and DNA encoding such proteins. Methods of generating such proteins and DNAs are also included.
US08124737B2 Stabilized preparations of serine endopeptidases, their preparation and use
The invention relates to stabilized preparations of serine endopeptidases which are suitable for use as a test reagent in a diagnostic procedure or for a therapeutic use. As a result of the addition of various additives, the preparations have improved stability and shelf life.
US08124736B2 Alpha-1-antitrypsin compositions
A streamlined method for purifying alpha-1-antitrypsin (AAT) from an AAT-containing protein mixture, such as a Cohn fraction IV precipitate, is provided. In the method of the invention, contaminating proteins are destabilized by cleavage of disulfide bonds with a reducing reagent, such as a dithiol, which does not affect AAT. The destabilized proteins are then preferentially adsorbed on a solid protein-adsorbing material, without the addition of a salt as a precipitant. Separation of the solid adsorbent from the solution leaves a purified AAT solution that is directly suitable for chromatographic purification, without the need for extensive desalting as in prior art processes. A process incorporating this method, which provides pharmaceutical grade AAT in high yield on a commercial scale, is also described.
US08124727B2 Use of modified metal oxides for enrichment of phosphopeptides
Use of modified metal oxides for the purification and enrichment of negatively charged biomolecules such as peptides, proteins, DNA, RNA, Lipids, carbohydrates, glyco molecules. These metal oxides are modified in such a way that the density of the Lewis acid group is reduced due to modification.
US08124726B2 Contoxin analogues and methods for synthesizing same
According to the present invention, there is provided a range of new conotoxin derivatives and methods for synthesizing these analogues and other intramolecular dicarba bridge-containing peptides, including dicarba-disulfide bridge-containing peptides.
US08124724B2 Peptides and related molecules that modulate nerve growth factor activity
The present invention relates to certain biologically active peptides and polypeptides which can be used as therapeutics or prophylactics against diseases or disorders linked to NGF as the causative agent. In one aspect of the present invention, pharmacologically active polypeptides comprising peptides linked to one or more Fc domains are provided.
US08124722B2 Soluble CD14 antigen
There are provided a soluble CD14 antigen which is a novel in vivo protein useful as a marker for diagnosing sepsis and has the following characteristic features 1) to 3): 1) a molecular weight of 13±2 kDa when measured by SDS-PAGE under non-reducing conditions; 2) an amino acid sequence in which the amino acid sequence of SEQ ID NO:1 is present on its N terminal; and 3) ability to specifically bind to an antibody prepared by using a peptide comprising 16 amino acid residues described in SEQ ID NO:2 for the antigen; and a recombinant soluble CD14 fragment.
US08124719B2 Furan resin composition for production of molds
A furan resin composition for production of molds has a urea content of 1 to 10 wt-% and a pH value (25° C.) of 7 to 10.
US08124718B2 Aminoplast resin of high performance for lignocellulosic materials
A process for preparing an aqueous aminoplastic urea-formaldehyde resin suitable for use in bonding lignocellulosic materials, which provides products of very low formaldehyde emission while maintaining superior performance.
US08124717B2 Morpholine-substituted poly(arylene ether) and method for the preparation thereof
A poly(2,6-dimethyl-1,4-phenylene ether) prepared using a morpholine-containing polymerization catalyst has a monomodal molecular weight distribution with a reduced content of very high molecular weight species. It also exhibits increased morpholine incorporation in the high molecular weight fraction. Compared to commercially available poly(2,6-dimethyl-1,4-phenylene ether) prepared using a di-n-butylamine-containing polymerization catalyst, the poly(2,6-dimethyl-1,4-phenylene ether) of the invention exhibits reduced odor. Compared to other poly(2,6-dimethyl-1,4-phenylene ether) prepared using a morpholine-containing polymerization catalyst, the poly(2,6-dimethyl-1,4-phenylene ether) of the invention exhibits improved molecular weight build during compounding and improved compatibilization with polyamides.
US08124716B2 Reacting compound having H-P=O, P-H or P-OH group with functional group-containing organic compound
Phosphorus-containing compounds are disclosed which are obtainable by reacting: (A) at least one organophosphorus compound having a group selected from the group H—P═O; the group P—H and the group P—OH; and (B) at least one compound having the following Formula (I): [R′(Y)m′]m(X—O—R″)n  Formula (I) wherein R′ is an organic group; Y is a functional group selected from the group consisting of hydroxy, carboxylic acid, and amine; X is a hydrocarbylene group; R″ is hydrogen or a hydrocarbyl group having from 1 to 8 carbon atoms, R is alkyl or aryl group having from 1 to 12 carbon atoms; m′, m and n are, independently, numbers equal to or greater than 1. These compounds are useful for making flame retardant epoxy and polyurethane resins and ignition resistant thermoplastic resins, each of which is useful for a variety of end uses requiring flame retardancy or ignition resistance. Flame retardant epoxy resins may be used to make electrical laminates. Flame retardant polyurethane is useful for making rigid polyurethane foam used in construction and flexible polyurethane foam used to make vehicle upholstery. Ignition resistant thermoplastic resins are useful for making television cabinets, computer monitors, printer housings, automotive parts, and housings and parts for appliances. This invention is particularly useful in end use applications in which a low bromine or low halogen content is required or desired.
US08124712B2 Filler for optical isomer separation
A filler for optical isomer separation which: allows a polymer compound derivative to be immobilized on the surface of a carrier at a high ratio and is excellent in optical separation ability. The filler is characterized in that the filler is obtained by modifying part of the hydroxy or amino groups of a polymer compound having the hydroxy or amino groups with molecules of a compound represented by the following general formula (I): A-X—Si(Y)nR3-n, and is carried by a carrier through chemical bonding.
US08124710B2 MQ-T propyl siloxane resins
MQ-T propyl siloxane resins comprising (R13SiO1/2)a, (R22SiO2/2)b, (R3SiO3/2)c, and (SiO4/2)d units, where at least 40 mole % of the R3 groups are propyl are disclosed. A method of preparing such siloxane resins by reacting a MQ siloxane resin with a T propyl siloxane resin is also disclosed. These siloxane resins are useful in a variety of personal, household, and medical care applications, and in particular, as a resin additive in pigmented cosmetic formulations.
US08124708B2 Polyolefin powder
Uncompounded polyolefin powder which is multimodal and has a particle size distribution such that D95 is less than 355 μm, D5 is at least 60 μm, and (D90−D10)/D50 is less than 1.2, where D95, D90, D50 and D10 are defined such that 95 wt %, 90 wt %, 50 wt % and 10 wt % of the polymer particles have a diameter of less than D95, D90, D50 and D10 respectively.
US08124697B2 Method of preventing or reducing agglomeration on grid in fluidized-bed vessel
A method for preventing or reducing agglomeration and/or accumulation on or around the gas distribution grid in a fluidized-bed vessel. The method involves introducing one or more scouring balls into the vessel above the gas distribution grid, and carrying out a fluidized-bed process in the presence of the scouring balls.
US08124696B2 Method of using an upper discharge in a fluidized bed reactor and system thereof
A method according to one embodiment includes operating a reactor or providing a reactor after operation, wherein the reactor includes a bottom section, a bed section above the bottom section, a distributor plate between the bottom section and the bed section, an expanded section above the bed section, and an upper section above the bed section, wherein the bed section has a height H measured from the distributor plate to the expanded section; measuring a concentration of particulates in the upper section of the reactor to obtain a first determined level of particulates in the upper section; and discharging at least some of the particulates from the reactor at an upper discharge point located above 0.55H as measured vertically from the distributor plate based on the first determined level. Additional systems and methods are also provided.
US08124691B2 Shape memory polymer with polyester and polyacrylate segments and process for its production and programming
The invention relates to a shape memory polymer, to a process for its production and to a process for its programming. The inventive shape memory polymer has at least two switching segments with different transition temperatures (Ttrans,1, Ttrans,2) such that the polymer, depending on the temperature, as well as a permanent shape (PF), can also assume at least two temporary shapes (TF1, TF2). The first switching segment is based essentially on a polyester of the general formula (I) where n=1 . . . 6 or a copolyester of the general formula (I) with different n or a derivative thereof. The second switching segment is based essentially on a polyacrylate of the general formula (II) in which R is H or CH3, and R1 is a saturated or unsaturated, cyclic or aliphatic, unsubstituted or substituted C1-C10 radical.
US08124690B2 Moisture curable polymer having SiF group, and curable composition containing the same
A moisture curable polymer and a curable composition having superior curability are provided. A polymer having a silicon group represented by the general formula: —SiFaR1bZc (wherein, R1 represents any one of a substituted or unsubstituted hydrocarbon group having 1 to 20 carbon atoms, or an organosiloxy group represented by R23SiO— (R2 is each independently, a substituted or unsubstituted hydrocarbon group having 1 to 20 carbon atoms). Z is a hydroxyl group or a hydrolyzable group other than fluorine. a is any one of 1, 2, or 3; b is any one of 0, 1, or 2; c is any one of 0, 1, or 2; and a+b+c is 3. When b or c is 2, two R1 or two Z may be each the same or different) and a curable composition including this polymer, and a sealant and an adhesive in which the curable composition is used.
US08124687B2 Random ethylene oxide copolymer and non-random alkylene oxide(s) polymer with bioactive agent
A polymeric material comprised of (i) at least one random copolymer comprised of ethylene oxide and one or more other alkylene oxide(s) and (ii) at least one non-random polymer comprised of one or more poly(alkylene oxide)s has been discovered. Preferably, it is a polymer alloy. Alkylene oxide homopolymers or block copolymers may be the non-random polymer. In a related discovery, an adhesive material can be made by suspending (a) particles in (b) a matrix of at least one poly(ethylene oxide) copolymer of ethylene oxide and propylene oxide, or a combination thereof. The handling characteristics may be adjusted for different utilities (e.g., from runny oil to hard wax). Applications include use as adhesive, cohesive, filler, lubricant, surfactant, or any combination thereof. In particular, the hard materials may be used for cleaning or waxing.
US08124686B2 Process for the manufacture of polyamide-12 powder with a high melting point
The present invention relates to a process for the preparation of polyamide-12 powder by anionic polymerization of lauryllactam in solution in a solvent of the lactam, the polyamide-12 powder being insoluble in this solvent, the polymerization being carried out: in the presence of a catalyst and of an activator; in the presence of a finely divided organic or inorganic filler, the proportion of this filler being less than or equal to 1.5 g per 1000 g of lauryllactam; and in the presence of an amide of formula R1—NH—CO—R2 in which R1 can be replaced by an R3—CO—NH— or R3—O— radical and in which R1, R2 and R3 denote an aryl, alkyl or cycloalkyl radical, the proportion of this compound being between 0.001 mol and 0.030 mol per 1000 g of lauryllactam.
US08124685B2 Adhesive composition and film adhesive
An adhesive composition of the present invention is an adhesive composition including a polymer obtained by copolymerizing a monomer composition containing a (meth)acrylic acid ester and a monomer having a maleimide group, the (meth)acrylic acid ester has a structure represented by General Formula (1): wherein R1 is a hydrogen atom or a methyl group, and R2 is a C4 to C20 alkyl group, and the (meth)acrylic acid ester is contained in the monomer composition by 10 to 50 parts by mass where an amount of the monomer composition is 100 parts by mass. With the arrangement, it is possible to provide an adhesive agent and a film adhesive each of which can be suitably used in high temperature processing.
US08124684B2 Friction composition for a seat belt and a seat belt coated with such a composition
The present invention relates to a low friction composition for a seat belt, characterized in that it comprises the following components: a polyether polyurethane; a low molecular weight polyurethane, with free NCO groups, and containing an aliphatic chain; a polyurethane without free NCO groups; a polyethylene; a polydimethylsiloxane. It also deals with a seat belt which is coated with such a composition.
US08124683B2 Polycarbonate resin composition with high weld line strength
A polycarbonate resin composition of the present invention comprises (A) about 30 to about 95 parts by weight of thermoplastic polycarbonate resin; (B) about 1 to about 50 parts by weight of rubber-modified-vinyl graft copolymer; (C) about 0 to about 50 parts by weight of vinyl copolymer; and (D) about 1 to about 50 parts by weight of amorphous thermoplastic polyester copolymer. The resin composition of the present invention can have excellent physical properties such as weld line strength, fluidity, impact resistance, and heat resistance.
US08124680B2 Coating compositions comprising a polyurethane polyol composition and nanoparticles, and process for preparing the same
The invention relates to a coating composition comprising a polyurethane polyol composition comprising the reaction product of a polyisocyanate and a polyol, and modified nanoparticles of silica and/or alumina, and to a process for preparing such coating composition.
US08124675B2 Adhesive composition
The invention relates to an adhesive composition comprising hydrophilic silicone elastomers and hydrophobic silicone elastomers and optionally water absorbent material, wherein the ratio between the hydrophilic silicone elastomers and the hydrophobic silicone elastomers is from 95:5 to 5:95. The adhesive is suited for medical use due to its skin-friendliness. The invention further relates to a medical device comprising said adhesive composition.
US08124672B2 Solid pigment preparations containing water-soluble anionic surface-active additives that comprise carboxylate groups
Disclosed are solid pigment preparations containing (A) 60 to 95 per weight of at least one pigment, (B) 5 to 40 percent by weight of at least one water-soluble anionic surface-active additive from the group of the homopolymers and copolymers of ethylenically unsaturated monocarboxylic acids and/or ethylenically unsaturated dicarboxylic acids which can additionally contain monopolymerized vinyl monomers having no acid function, the alkoxylation products of said homopolymers and copolymers, and the salts of said homopolymers and copolymers and the alkoxylation products thereof, and (C) 0 to 20 percent by weight of at least one nonionic surface-active polyether-based additive as essential components. Also disclosed are a method for the production thereof and methods for dyeing macromolecular organic and inorganic materials.
US08124668B2 Silicone-containing ocular lens material with high safety and preparing method thereof
[Problem] To provide a safe ocular lens material having high oxygen permeability, excellent surface wettability, the excellent lubricity/easy lubricating property of surface, little in surface adhesive and superior flexibility and stress relaxation, in addition, suppressing elution of a monomer from the final product.[Means for Solving the Problem] An ocular lens comprising a compound (A) having an ethylenically unsaturated group and polydimethylsiloxane structure through a urethane bond and an 1-alkyl-3-methylene-2-pyrrolidone (B).[Selected Figure] None
US08124666B2 Energy ray-curable ink composition
An object of the present invention is to provide an energy ray-curable ink composition which is excellent in curability and adhesion, and is also excellent in storage stability.The present invention relates to an energy ray-curable ink composition comprising a coloring material; a polyfunctional monomer having three or more ethylenical double bonds in one molecule as a polymerizable compound; an α-aminoalkylphenone-based compound and a thioxanthone-based compound as photopolymerization initiators; and a hindered amine-based compound having a 2,2,6,6-tetramethylpiperidinyl group as an antigelling agent.
US08124663B2 Foamed isocyanate-based polymer having improved hardness properties and process for production thereof
The invention relates to the surprising and unexpected discovery that a sub-group of phenolic resins (i.e., those which are substantially completely free of ether moieties) is particularly advantageous to confer load building properties to an isocyanate-based foam (e.g., a polyurethane foam). Indeed, its possible to utilize the sub-group of phenolic resins to partially or fully displace copolymer polyols conventionally used to confer load building characteristics to isocyanate-based polymer foams. Further, the invention relates to the surprising and unexpected discovery that a sub-group of phenolic resins (i.e., those which are substantially completely free of ether moieties) is particularly advantageous to confer energy absorption properties in an isocyanate-based foam.
US08124655B2 Use of LR-90 and LR-102 to overcome insulin resistance
The present invention provides methods for ameliorating, overcoming, or inhibiting insulin resistance in a subject, comprising administering to the subject an effective amount of a compound selected from the group consisting of LR-90 and LR-102, or a pharmaceutically acceptable salt or derivative thereof. Methods of treating type 2 diabetes and diabetic nephropathy, or preventing or slowing their development are also encompassed by the invention.
US08124653B2 Methods and compositions for the treatment of attention deficit hyperactivity disorder and hyperphenylalanemia
Disclosed is a composition that includes a tetrahydrobiopterin in a controlled-release pharmaceutical preparation. Also disclosed is a method of treating a patient with phenylketonuria that includes administering, to the patient, a composition that contains tetrahydrobiopterin in a controlled-release pharmaceutical preparation. Also disclosed is a method of treating a patient with ADHD that includes administering a tetrahydropterin to the patient. Compositions for the treatment of ADHD are also described.
US08124652B2 Use of parthenolide derivatives as antileukemic and cytotoxic agents
The present invention provides compounds of the formula (I) wherein: X1, X2 and X3 are heteroatoms; R4, R5, R6, R7, R8, R9 and R10 are independently selected from H, halo, —OH, —NO2, —CN and optionally substituted aliphatic, cycloalkyl, heterocycloalkyl, aryl or heteroaryl; and Z is optionally substituted C1-8 straight-chained or branched aliphatic, optionally containing 1 or more double or triple bonds, wherein one or more carbons are optionally replaced by R* wherein R* is optionally substituted cycloalkyl, heterocycloalkyl, aryl or heteroaryl; an amino acid residue, H, —CN, —C(O)—, —C(O)C(O)—, —C(O)NR1—, —C(O)NR1NR2—, —C(O)O—, —OC(O)—, —NR1CO2—, —O—, —NR1C(O)NR2—, —OC(O)NR1—, —NR1NR2—, —NR1C(O)—, —S—, —SO—, —SO2—, —NR1—, —SO2NR1—, —NR1R2, or —NR1SO2—, wherein R1 and R2 are independently selected from H and optionally substituted aliphatic, cycloalkyl, heterocycloalkyl, aryl or heteroaryl; or where R* is NR1R2, R1 and R2 optionally together with the nitrogen atom form an optionally substituted 5-12 membered ring, said ring optionally comprising 1 or more heteroatoms or a group selected from —CO—, —SO—, —SO2— and —PO—; or a pharmaceutically acceptable salt, ester or prodrug thereof.
US08124650B2 Antitumor combinations containing taxane derivatives and epidophyllotoxins
Antitumor combinations comprising a taxane and at least one epidophllotoxin for treating neoplastic diseases are described.
US08124646B2 Substituted isoindoline-1,3-dione derivatives
This invention relates to novel substituted isoindoline-1,3-dione derivatives and pharmaceutically acceptable salts thereof. More specifically, the invention relates to novel substituted isoindoline-1,3-dione derivatives that are analogues of apremilast. This invention also provides compositions comprising a compound of this invention and a carrier and the use of disclosed compounds and compositions in methods of treating diseases and conditions that are beneficially treated by administering apremilast.
US08124645B2 LPA receptor antagonist
A compound of the general formula (I): (wherein the symbols are as defined in the description), or a non-toxic salt thereof. This compound engages in LPA receptor bonding and antagonism and hence is useful in the prevention and/or treatment of urinary system disease (symptom with prostatic hypertrophy or neurogenic bladder dysfunction disease, symptom to be caused by spinal cord neoplasm, nucleous hernia, spinal canal stenosis or diabetes, occlusion disease of lower urinary tract, inflammatory disease of lower urinary tract, polyuria), carcinoma-associated disease (solid tumor, solid tumor metastasis, angiofibroma, myeloma, multiple myeloma, Kaposi's sarcoma, leucemia and carcinomatous infiltration transition), proliferative disease (disorder with aberrant angiogenesis, artery obstruction and pulmonary fibrosis), inflammation/immune system disease (psoriasis, nephropathy, hepatitis and pneumonitis symptom), disease caused by secretory dysfunction (Sjogren syndrome), brain-related disease (brain infarction, cerebral apoplexy and brain or peripheral neuropathy) or chronic disease (chronic asthma, glomerulonephritis, obesity, prostate hyperplasia, diseases caused by arteriosclerosis process, rheumatism or atopic dermatitis).
US08124642B2 Pesticidal N-phenylpyrazole derivatives
The invention relates to 5-(substituted dithio- or dioxy-alkylamino)pyrazole derivatives of formula (I) or salts thereof: wherein the various symbols are as defined in the description, to processes for their preparation, to compositions thereof, and to their use for the control of pests (including arthropods and helminths).
US08124639B2 Bicyclic [3.1.0] heteroaryl amides as type 1 glycine transport inhibitors
The present invention relates to a series of substituted bicyclic[3.1.0]heteroaryl amides of the Formula I, wherein A, Q, X, Y, Z and R1-R5 groups are defined as in the specification, that exhibit activity as glycine transport inhibitors, their pharmaceutically acceptable salts, pharmaceutical compositions containing them, and their use for the enhancement of cognition and the treatment of the positive and negative symptoms of schizophrenia and other psychoses in mammals, including humans.
US08124638B2 Tricyclic compounds useful as angiotensin II agonists
There is provided compounds of formula (I), wherein X1, X2, X3, Y4, Y1, Y2, Y3, Y4, Z1, Z2, R4 and R5 have meanings given in the description, and pharmaceutically-acceptable salts thereof, which compounds are useful as selective agonists of the AT2 receptor, and thus, in particular, in the treatment of inter alia gastrointestinal conditions, such as dyspepsia, IBS and MOF, and cardiovascular disorders.
US08124637B2 Anthra [1, 2-d]imidazole-6,11-dione derivatives, preparation method and application thereof
A series of novel anthra[1,2-d]imidazole-6,11-dione derivatives, and the preparation method and application of said derivatives, wherein said application includes a pharmaceutical composition containing said derivatives for treating cancer, and said application involves effects of said derivatives for inhibiting telomerase activity, inhibiting the growth of cancer cell, treating cancer and the like.
US08124635B2 Antimicrobial composition useful for preserving wood
Antimicrobial compositions useful for preserving wood, and comprising a variety of antimicrobial compounds.
US08124627B2 Biphenyl compounds useful as muscarinic receptor antagonists
The invention provides compounds of formula I: wherein a, b, c, m, n, q, r, W, Z1, Ar1, Z2, R1, R2, and R3 are as defined in the specification. The compounds of formula I are muscarinic receptor antagonists. The invention also provides pharmaceutical compositions containing such compounds, processes and intermediates for preparing such compounds and methods of using such compounds to treat pulmonary disorders.
US08124618B2 3-substituted-2(arylalkyl)-1-azabicycloalkanes and methods of use thereof
The present invention relates to pharmaceutical compositions incorporating compounds capable of affecting nicotinic acetylcholinergic receptors (nAChRs), for example, as modulators of specific nicotinic receptor subtypes (specifically, the α7 nAChR subtype). The present invention also relates to methods for treating a wide variety of conditions and disorders, particularly those associated with dysfunction of the central and autonomic nervous systems.
US08124617B2 Imidazopyridine compounds
Compounds, pharmaceutical compositions, kits and methods are provided for use with glucokinase that comprise a compound selected from the group consisting of formula (I) wherein the variables are as defined herein.
US08124615B2 Diketo substituted pyrrolo[2,3-C]pyridines
Compounds having drug and bio-affecting properties, their pharmaceutical compositions and methods of use are set forth. In particular, diketo fused azolopiperidine and azolopiperazine derivatives of Formula I: that possess unique antiviral activity are provided. These compounds are useful for the treatment of HIV and AIDS.
US08124614B2 Steroidal compounds for inhibiting steroid sulphatase
There is provided a compound having Formula (I) wherein G is H or a substituent, and wherein R1 is any one of a sulphamate group, a phosphonate group, a thiophosphonate group, a sulphonate group or a sulphonamide group, capable of inhibiting steroid sulphatase.
US08124612B2 Treating neurological disorders using selective antagonists of persistent sodium current
The present invention provides methods of treating neurological disorders in a mammal by administering to the mammal an effective amount of a selective persistent sodium channel antagonist that has at least 20-fold selectivity for persistent sodium current relative to transient sodium current.
US08124610B2 Sodium channel inhibitors
Compounds, compositions and methods are provided which are useful in the treatment of diseases through the inhibition of sodium ion flux through voltage-gated sodium channels. More particularly, the invention provides substituted sulfonamides, compositions comprising these compounds, as well as methods of using these compounds or compositions in the treatment of central or peripheral nervous system disorders, particularly pain and chronic pain by blocking sodium channels associated with the onset or recurrence of the indicated conditions. The compounds, compositions and methods of the present invention are of particular use for treating neuropathic or inflammatory pain by the inhibition of ion flux through a voltage-gated sodium channel.
US08124608B2 Stable pharmaceutical composition of freeze-dried tetrodotoxin powder
This invention relates to a stable pharmaceutical composition of freeze-dried tetrodotoxin powder which contains trace amount of tetrodotoxin, substances which can stabilizes tetrodotoxin, including disaccharide(s) or polyglucose(s) or analogues thereof and solvent(s), and solvents which can help tetrodotoxin dissolve.
US08124605B2 Compositions and methods for modulating a kinase cascade
The invention relates to compounds and methods for modulating one or more components of a kinase cascade.
US08124604B2 Inhibitors of bruton's tyrosine kinase
This application discloses 5-phenyl-1H-pyridin-2-one and 6-phenyl-2H-pyridazin-3-one derivatives according to generic Formulae I-IV: wherein, variables R, X, Y1, Y2, Y2′, Y3, Y4, n and m are defined as described herein, which inhibit Btk. The compounds disclosed herein are useful to modulate the activity of Btk and treat diseases associated with excessive Btk activity. The compounds are further useful to treat inflammatory and auto immune diseases associated with aberrant B-cell proliferation such as rheumatoid arthritis. Also disclosed are compositions comprising compounds of Formulae I-IV and at least one carrier, diluent or excipient.
US08124603B2 In vivo studies of crystalline forms of meloxicam
The invention is directed to novel crystalline forms of meloxicam. These novel crystalline forms of meloxicam have improved bioavailability, an enhanced rate of dissolution and shorter time to Cmax in blood, as compared to pure meloxicam.
US08124601B2 Compounds for the treatment of Hepatitis C
The invention encompasses compounds of formula I as well as compositions and methods of using the compounds. The compounds have activity against hepatitis C virus (HCV) and are useful in treating those infected with HCV.
US08124596B2 Demethylpenclomedine analogs and their use as anti-cancer agents
This disclosure concerns novel demethylpenclomedine analogs. Also disclosed are pharmaceutical compositions and methods for using such compositions to treat hyperproliferative disorders. In one embodiment the analogs are represented by the formula (1).
US08124594B2 Methods using phosphatidylserine, lysophosphatidylserine, and/or salts thereof to increase testosterone levels
Methods using phosphatidylserine, lysophosphatidylserine, and/or salts thereof to increase testosterone levels in subjects in need thereof are disclosed herein. The methods can be useful for subjects having age related decline in testosterone, exercise induced decline in testosterone, and/or hypogonadism.
US08124593B2 Methods of treatment using sapacitabine
A first aspect of the invention relates to a method of treating leukaemia or myelodysplastic syndromes (MDS), said method comprising administering a therapeutically effective amount of sapacitabine, or a metabolite thereof, to a subject in accordance with a dosing regimen comprising at least one treatment cycle, wherein said treatment cycle comprises administering a therapeutically effective amount of sapacitabine, or a metabolite thereof, for 7 consecutive days every 21 days or 14 consecutive days every 21 days.A second aspect of the invention relates to a method of treating a proliferative disorder, said method comprising administering a therapeutically effective amount of sapacitabine, or a metabolite thereof, to a subject in accordance with a dosing regimen comprising at least one treatment cycle, wherein said treatment cycle comprises administering a therapeutically effective amount of sapacitabine, or a metabolite thereof, for 7 consecutive days every 21 days or 14 consecutive days every 21 days, wherein the sapacitabine, or metabolite thereof, is administered in the form of a liquid filled capsule.A third aspect of the invention relates to a method of treating a proliferative disorder, said method comprising administering a therapeutically effective amount of sapacitabine, or a metabolite thereof, to a subject in accordance with a dosing regimen comprising at least one treatment cycle, wherein said treatment cycle comprises administering a therapeutically effective amount of sapacitabine, or a metabolite thereof, for 7 consecutive days every 21 days.Further aspects of the invention relate to kits directed to the same.
US08124592B2 Development of a preventive vaccine for filovirus infection in primates
The present invention relates generally to viral vaccines and, more specifically, to filovirus vaccines and methods of eliciting an immune response against a filovirus or disease caused by infection with filovirus.
US08124589B2 Use of ketogenic compounds for treatment of age-associated memory impairment
This invention relates to the field of therapeutic agents for the treatment of Age-Associated Memory Impairment (AAMI). In particular, the present invention utilizes compositions comprising at least one compound capable of elevating ketone body concentrations in a mammal (e.g., ketogenic compounds), administered in an amount effective for treatment or prevention of loss of cognitive function caused by reduced neuronal metabolism in AAMI. In one embodiment, the composition includes medium chain triglycerides (MCT). In another embodiment, the compositions are administered in the presence of carbohydrate. The present invention also relates to oral dosage forms, in particular, a nutritional drink comprising at least one compound capable of elevating ketone body concentrations in a mammal.
US08124588B2 Chimeric plasminogen activators and their pharmaceutical use
The present invention relates to recombinant chimeric proteins comprising a surfactant protein precursor N-terminally fused to a plasminogen activator or comprising a mature surfactant protein N-terminally or C-terminally fused to a plasminogen activator. The invention is also directed to the corresponding nucleic acid molecules encoding such fusion proteins as well as to a method for their production. The invention further refers to a pharmaceutical composition comprising such a fusion protein and to pharmacological uses of an inventive fusion protein for the prevention and/or treatment of inflammatory and interstitial lung diseases.
US08124584B2 Macrocyclic hepatitis C serine protease inhibitors
The present invention relates to compounds of Formula I, II or III, or a pharmaceutically acceptable salt, ester, or prodrug, thereof: wherein W is a substituted or unsubstituted heterocyclic ring system. The compounds inhibit serine protease activity, particularly the activity of hepatitis c virus (HCV) NS3-NS4A protease. Consequently, the compounds of the present invention interfere with the life cycle of the hepatitis c virus and are also useful as antiviral agents. The present invention further relates to pharmaceutical compositions comprising the aforementioned compounds for administration to a subject suffering from HCV infection. The invention also relates to methods of treating an HCV infection in a subject by administering a pharmaceutical composition comprising the compounds of the present invention.
US08124581B2 Methods for treating breast cancer using NRIF3 related molecules
Disclosed herein is the discovery that administration of the NRIF3 family of transcriptional coregulators (NRIF3 and related molecules) to breast cancer cells induce rapid and profound apoptosis (nearly 100% cell death within 24 h). A novel death domain (DD1) was mapped to a short 30 amino acid region common to all members of the NRIF3 family. Two other death domains (DD2 and DD3) were also found to have effective breast cancer killing activities. Mechanistic studies showed that DD1-induced apoptosis occurred through a novel caspase-2 mediated pathway that involved mitochondria membrane permeabilization but did not require other caspases. Interestingly, cytotoxicity of NRIF3 related molecules was cell-type specific, as they selectively killed breast cancer or related cells but not other examined cells of different origins, suggesting the presence in breast cancer cells of a specific death switch that can be selectively triggered by NRIF3 and related molecules. Also disclosed are strategies utilizing NRIF3 related molecules and/or targeting this death switch for the development of novel and more selective therapeutics against breast cancer.
US08124576B2 Detergent composition comprising a 2-phenyl isomer alkyl benzene sulfonate and an amino alcohol
The present invention relates to a liquid detergent comprising less than 40% total water or non-amino functional solvent, alkyl benzene sulphonate surfactant comprising greater than 20% of the 2 phenyl isomer and a gel breaker selected from the group consisting of amino alcohol compounds having a molecular weight above 61 g/mol, wherein the composition has a ratio of total surfactant to total solvent of greater than 1:1.
US08124574B2 Mild, foaming liquid cleansers comprising low levels of fatty isethionate product and low total fatty acid and/or fatty acid soap content
The present invention relates to liquid personal care composition comprising both low levels of specific fatty isethionate product (e.g., less than 4%) and low overall fatty acid content (less than 4%) which, quite surprisingly, maintain excellent foaming profile relative to identical composition having high overall fatty acid content.
US08124569B2 Control of the properties of cement slurries of normal densities with optimized polymers combination
The invention discloses a cement slurry composition for cementing a well comprising: an hydraulic cement, water and a combination made of a cellulosic polymer and an acrylamido-methyl-propane sulfonate co- or ter-polymer, wherein the density of said cement slurry is above 1700 kg/m3.
US08124568B2 Oxide superconductor and method of fabricating same
An oxide superconductor with superconduction properties being improved by effectively introducing a pinning center thereinto and its fabrication method are disclosed. The superconductor has a high-crystallinity oxide superconductor film which is formed on a substrate with a <001> direction of crystal grain being oriented almost perpendicularly to the substrate and with (100) planes of neighboring crystal grains being oriented to form an oblique angle ranging from 0 to 4 degrees or 86 to 90 degrees. The film has a multilayer structure including a plurality of high-density magnetic field trap layers stacked in almost parallel to the substrate and a low-density magnetic field trap layer sandwiched therebetween. An average grain boundary width of the high-density trap layers in a cross-section horizontal to the substrate is 80 nm or less. The width is less than an average grain boundary width of the low-density trap layer in its cross-section horizontal to the substrate.
US08124565B2 Method of protecting a plant propagation material, a plant, and/or plant organs
A method of controlling or preventing pathogenic damage or pest damage in a plant propagation material, a plant, and/or plant organs that grow at a later point in time, which comprises applying on the plant propagation material a compound of formula (I) and stereoisomers, diastereomers, and agronomically acceptable salts thereof.
US08124564B2 Use of alkyl carboxylic acid amides as penetration enhancers
Use of carboxamides of the formula (I) R1—CO—NR2R3  (I), in which R1 represents C3-C19-alkyl, R2 represents C1-C6-alkyl and R3 represents H or C1-C6-alkyl for promoting the penetration of agrochemical active substances into plants.
US08124554B2 Fused cast refractory block with high zirconia content
The present invention provides a fused cast refractory block comprising a mean zirconia (ZrO2+HfO2) content of more than 85% as a percentage by weight based on the oxides, and with a standard deviation σ of the local zirconia content divided by the volume of the block of less than 7.5.
US08124549B2 Non-woven fabric
This invention provides a composition for forming a fabric by spraying onto a supporting surface, the composition comprising fibers, a binder and a diluent. Further aspects of the invention include the fabric formed by spraying the composition and an article comprising the fabric, an apparatus and a method for spraying the composition.
US08124548B2 Low weight and high durability soft body armor composite using silicone-based topical treatments
Ballistic resistant articles having abrasion resistance. Particularly, abrasion resistant, ballistic resistant articles and composites having a silicone-based topical treatment.
US08124545B2 Methods of etching oxide, reducing roughness, and forming capacitor constructions
The invention includes methods in which one or more components of a carboxylic acid having an aqueous acidic dissociation constant of at least 1×10−6 are utilized during the etch of oxide (such as silicon dioxide or doped silicon dioxide). Two or more carboxylic acids can be utilized. Exemplary carboxylic acids include trichloroacetic acid, maleic acid, and citric acid.
US08124541B2 Etchant gas and a method for removing material from a late transition metal structure
An etchant gas and a method for removing at least a portion of a late transition metal structure. The etchant gas includes PF3 and at least one oxidizing agent, such as at least one of oxygen, ozone, nitrous oxide, nitric oxide and hydrogen peroxide. The etchant gas provides a method of uniformly removing the late transition metal structure or a portion thereof. Moreover, the etchant gas facilitates removing a late transition metal structure with an increased etch rate and at a decreased etch temperature. A method of removing a late transition metal without removing more reactive materials proximate the late transition metal and exposed to the etchant gas is also disclosed.
US08124539B2 Plasma processing apparatus, focus ring, and susceptor
A plasma processing apparatus having a focus ring, enables the efficiency of cooling of the focus ring to be greatly improved, while preventing an increase in cost thereof. The plasma processing apparatus is comprised of a susceptor which has an electrostatic chuck and the focus ring. A wafer W to be subjected to plasma processing is mounted on the electrostatic chuck. The focus ring has a dielectric material portion and a conductive material portion. The dielectric material portion forms a contact portion disposed in contact with the electrostatic chuck. The conductive material portion faces the electrostatic chuck with the dielectric material portion therebetween.
US08124537B2 Method for etching integrated circuit structure
A method is disclosed for etching an integrated circuit structure within a trench. A layer to be etched is applied over the structure and within the trench. A CF-based polymer is deposited over the layer to be etched followed by deposition of a capping layer of SiOCl-based polymer. The CF-based polymer reduces the width of the trench to such an extent that little or no SiOCl-based polymer is deposited at the bottom of the trench. An O2 plasma etch is performed to etch through the CF-based polymer at the bottom of the trench. The O2 plasma etch has little effect on the SiOCl-based polymer, the thus the upper surfaces of the structure remain covered with polymer. Thus, these upper surfaces remain fully protected during subsequent etching of the layer to be etched.
US08124535B2 Method of fabricating solar cell
A method of fabricating a solar cell is provided. A saw damage removal process is performed on a silicon substrate. A dry surface treatment is performed to a surface of the silicon substrate on form an irregular surface. A metal-activated selective oxidation is performed to the irregular surface. By using an aqueous solution, the irregular surface is etched to form a nanotexturized surface of the silicon substrate. A dopant diffusion process is performed on the silicon substrate to form a P-N junction. An anti-reflection layer is formed on the silicon substrate. An electrode is formed on the silicon substrate.
US08124532B2 Semiconductor device comprising a copper alloy as a barrier layer in a copper metallization layer
By forming a tin and nickel-containing copper alloy on an exposed copper surface, which is treated to have a copper oxide thereon, a reliable and highly efficient capping layer may be provided. The tin and nickel-containing copper alloy may be formed in a gaseous ambient on the basis of tin hydride and nickel, carbon monoxide in a thermally driven reaction.
US08124530B2 Method of preventing generation of arc during rapid annealing by joule heating
Disclosed herein is a rapid annealing method in a mixed structure composed of a heat treatment-requiring material, dielectric layer and conductive layer, comprising that during rapid annealing on a predetermined part of the heat treatment-requiring material, by instantaneously generated intense heat due to Joule heating by application of an electric field to the conductive layer, the potential difference between the heat treatment-requiring material and the conductive layer is set lower than the dielectric break-down voltage of the dielectric layer, thereby preventing generation of arc by dielectric breakdown of the dielectric layer during the annealing.
US08124527B2 CMP process flow for MEMS
The present invention generally relates to the formation of a micro-electromechanical system (MEMS) cantilever switch in a complementary metal oxide semiconductor (CMOS) back end of the line (BEOL) process. The cantilever switch is formed in electrical communication with a lower electrode in the structure. The lower electrode may be either blanket deposited and patterned or simply deposited in vias or trenches of the underlying structure. The excess material used for the lower electrode is then planarized by chemical mechanical polishing or planarization (CMP). The cantilever switch is then formed over the planarized lower electrode.
US08124525B1 Method of forming self-aligned local interconnect and structure formed thereby
Embodiments of the present invention provide a method of forming local interconnect for semiconductor devices. The method includes depositing a blanket layer of conductive material over one or more semiconductor devices; creating a pattern of local interconnect covering a portion of the blanket layer of conductive material; removing rest of the blanket layer of conductive material that is not covered by the pattern of local interconnect; forming the local interconnect by the portion of the blanket layer of conductive material to connect the one or more semiconductor devices.
US08124523B2 Fabrication method of a semiconductor device and a semiconductor device
A method for fabricating a semiconductor device includes the steps of (a) forming a plasma of a gas having carbon and fluorine, and forming an internal insulation film provided with a fluorine-doped carbon film formed on a substrate using the plasma; (b) forming a metal film on the internal insulation film; (c) etching the metal film according to a pattern to form a hard mask; (d) forming a concave part in the fluorine-doped carbon film by etching the fluorine-doped carbon film using the hard mask; (e) forming a film formation of a wiring material on the substrate for filling the concave part with the wiring material; (f) removing an excess part of the wiring material and the hard mask on the fluorine-doped carbon film for exposing a surface of the fluorine-doped carbon film; and (g) removing an oxide formed on the surface of the fluorine-doped film.
US08124520B2 Integrated circuit mount system with solder mask pad
An integrated circuit mount system includes an integrated circuit, a solder mask for the integrated circuit, and a solder mask pad on the substrate with the solder mask.
US08124517B2 Method of forming an interconnect joint
A method of forming an interconnect joint includes providing a first metal layer (210, 310), providing a film (220, 320) including metal particles (221, 321) and organic molecules (222, 322), placing the film over the first metal layer, placing a second metal layer (230, 330) over the film, and sintering the metal particles such that the organic molecules degrade and the first metal layer and the second metal layer are joined together.
US08124514B2 Nonvolatile semiconductor storage device and method for manufacturing same
A nonvolatile semiconductor storage device includes: a plurality of stacked units juxtaposed on a major surface of a substrate, each stacked unit aligning in a first direction parallel to the major surface of the substrate; and a gate electrode aligning parallel to the major surface in a second direction non-parallel to the first direction. Each of the plurality of stacked units includes a plurality of stacked semiconductor layers via an insulating layer. The plurality of stacked units are juxtaposed so that the spacings between adjacent stacked units are alternately a first spacing and a second spacing larger than the first spacing. The second spacing is provided at a periodic interval four times a size of a half pitch F of the bit line. The gate electrode includes a protruding portion that enters into a gap of the second spacing between the stacked units. A first insulating film, a charge storage layer, and a second insulating film are provided between a side face of the semiconductor layer and the protruding portion.
US08124512B2 Methods of forming integrated circuit devices having different gate electrode cross sections
A semiconductor device includes a first conductive structure and a second conductive structure. The first conductive structure is formed in a first region of a substrate, and includes a first polysilicon layer pattern, a first conductive layer pattern having a resistance smaller than that of the first polysilicon layer pattern, and a first hard mask. The second conductive structure is formed in a second region of the substrate and has a thickness substantially the same as that of the first conductive structure. The second conductive structure includes a second polysilicon layer pattern, a second conductive layer pattern having a resistance smaller than that of the second polysilicon layer pattern and having a thickness different from that of the first conductive layer pattern, and a second hard mask.
US08124510B2 Method of manufacturing a silicon carbide semiconductor device
A method of manufacturing a silicon carbide semiconductor device is disclosed in which a trench and a hole are controlled to have a predetermined configuration even if the silicon carbide semiconductor device is subjected to a heat treatment at a temperature of not lower than 1,500° C. A heat treatment step(s) of a method of the invention includes a step of heat treatment in an argon atmosphere at a temperature in a range of 1,600° C. to 1,800° C. under a pressure of at most 10 Torr for a time duration in a range of 0.1 min to 10 min to evaporate silicon atoms from a surface of the silicon carbide semiconductor substrate or the silicon carbide epitaxial layer and to obtain a silicon carbide surface with a carbon atom concentration of at least 95%. The method can further comprise a step of ion implantation of nitrogen ions or phosphorus ions in a dose amount of 8×1014 cm−2 into a surface of the silicon carbide semiconductor substrate or into the silicon carbide epitaxial layer, followed by the step of heat treatment at a temperature of 1,500° C. or higher. The method can comprise a step of heat treatment in an atmosphere of argon gas at a temperature in a range of 1,600° C. to 1,800° C. containing monosilane in an amount of at least 0.2%.
US08124502B2 Semiconductor device manufacturing method, semiconductor device and semiconductor device manufacturing installation
A semiconductor device manufacturing method is provided, including: providing a semiconductor substrate, forming on the semiconductor substrate a layer including a semiconductor compound and a dope additive, and thereafter forming an emitter region and gettering impurities by annealing the semiconductor substrate including the layer.
US08124495B2 Semiconductor device having enhanced photo sensitivity and method for manufacture thereof
Provided are a semiconductor device and a method for its manufacture. In one example, the method includes forming an isolation structure having a first refraction index over a sensor embedded in a substrate. A first layer having a second refraction index that is different from the first refraction index is formed over the isolation structure. The first layer is removed from at least a portion of the isolation structure. A second layer having a third refraction index is formed over the isolation structure after the first layer is removed. The third refraction index is substantially similar to the first refraction index.
US08124490B2 Semiconductor device and method of forming passive devices
A flip chip semiconductor device has a substrate with a plurality of active devices formed thereon. A passive device is formed on the substrate by depositing a first conductive layer over the substrate, depositing an insulating layer over the first conductive layer, and depositing a second conductive layer over the insulating layer. The passive device is a metal-insulator-metal capacitor. The deposition of the insulating layer and first and second conductive layers is performed without photolithography. An under bump metallization (UBM) layer is formed on the substrate in electrical contact with the plurality of active devices. A solder bump is formed over the UBM layer. The passive device can also be a resistor by depositing a resistive layer over the first conductive layer and depositing a third conductive layer over the resistive layer. The passive device electrically contacts the solder bump.
US08124488B2 Method of fabricating memory
A method of fabricating a memory is provided. A substrate comprising a memory region and a periphery region is provided. A plurality of gates is formed on the substrate and a first spacer is formed on a sidewall of each gate, where a plurality of openings is formed between the gates in the memory region. A first material layer formed on the substrate in the memory region covers the gates in the memory region and fills the openings. A process is performed to the periphery region. The first material layer is partially removed to form a first pattern in each opening respectively. A second material layer formed on the substrate covers the memory region and the periphery region to expose the first patterns. The first patterns are removed to form a plurality of contact openings in the second material layer. The contact plugs are formed in the contact openings.
US08124472B2 Manufacturing method of a semiconductor device
A semiconductor device includes a first pMISFET region having an Si channel, a second pMISFET region having an Si channel and an nMISFET region having an Si channel. First SiGe layers which apply first compression strain to the Si channel are embedded and formed in the first pMISFET region to sandwich the Si channel thereof and second SiGe layers which apply second compression strain different from the first compression strain to the Si channel are embedded and formed in the second pMISFET region to sandwich the Si channel thereof.
US08124471B2 Method of post-mold grinding a semiconductor package
A method of grinding a molded semiconductor package to a desired ultra thin thickness without damage to the package is disclosed. Prior to grinding a molded package to a desired package thickness, the package may be protected from excessive mechanical stress generated during grinding by applying a protective tape to enclose interconnects formed on the package. This way, the protective tape provides support to the semiconductor package during package grinding involving the mold material as well as the die. In the post-grind package, the grinded die surface may be exposed and substantially flush with the mold material. The protective tape may then be removed to prepare the post-grind package for connection with an external device or PCB.
US08124470B1 Strained thin body semiconductor-on-insulator substrate and device
A method of forming a strained, semiconductor-on-insulator substrate includes forming a second semiconductor layer on a first semiconductor substrate. The second semiconductor is lattice matched to the first semiconductor substrate such that the second semiconductor layer is subjected to a first directional stress. An active device semiconductor layer is formed over the second semiconductor layer such that the active device semiconductor layer is initially in a relaxed state. One or more trench isolation structures are formed through the active device layer and through the second semiconductor layer so as to relax the second semiconductor layer below the active device layer and impart a second directional stress on the active device layer opposite the first directional stress.
US08124469B2 High-efficiency filler cell with switchable, integrated buffer capacitance for high frequency applications
A cell based integrated circuit chip includes a top voltage supply rail and a bottom voltage supply rail and a plurality of metal layers defining at least one filler cell. The filler cell is formed by a first field effect transistor of a first type conductivity, typically an n-channel MOSFET. The source or drain electrodes of the n-channel MOSFET are arranged to as act as a capacitor with respect to the bottom voltage supply rail and to which at least one of the source and drain electrodes is connected. A second field effect transistor of an opposite-type conductivity to the first field effect transistor, typically a p-channel MOSFET, is also provided. The source or drain electrodes of the p-channel MOSFET are connected in series between the top voltage supply rail and a gate electrode of the n-channel MOSFET. The gate electrode of the p-channel MOSFET is connected to a source of ground potential via a resistor.
US08124468B2 Process of forming an electronic device including a well region
An electronic device including an integrated circuit can include a buried conductive region and a semiconductor layer overlying the buried conductive region, and a vertical conductive structure extending through the semiconductor layer and electrically connected to the buried conductive region. The integrated circuit can further include a doped structure having an opposite conductivity type as compared to the buried conductive region, lying closer to an opposing surface than to a primary surface of the semiconductor layer, and being electrically connected to the buried conductive region. The integrated circuit can also include a well region that includes a portion of the semiconductor layer, wherein the portion overlies the doped structure and has a lower dopant concentration as compared to the doped structure. In other embodiment, the doped structure can be spaced apart from the buried conductive region.
US08124466B2 Process for manufacturing voltage-controlled transistor
The present invention provides a self-driven LDMOS which utilizes a parasitic resistor between a drain terminal and an auxiliary region. The parasitic resistor is formed between two depletion boundaries in a quasi-linked deep N-type well. When the two depletion boundaries pinch off, a gate-voltage potential at a gate terminal is clipped at a drain-voltage potential at said drain terminal. Since the gate-voltage potential is designed to be equal to or higher than a start-threshold voltage, the LDMOS is turned on accordingly. Besides, no additional die space and masking process are needed to manufacture the parasitic resistor. Furthermore, the parasitic resistor of the present invention does not lower the breakdown voltage and the operating speed of the LDMOS. In addition, when the two depletion boundaries pinch off, the gate-voltage potential does not vary in response to an increment of the drain-voltage potential.
US08124465B2 Method for manufacturing a semiconductor device having a source extension region and a drain extension region
There is provided a semiconductor device including: convex semiconductor layers formed on a semiconductor substrate via an insulating film; gate electrodes formed on a pair of facing sides of the semiconductor layers via a gate insulating film; a channel region formed of silicon between the gate electrodes in the semiconductor layers; a source extension region and a drain extension region formed of silicon germanium or silicon carbon on both sides of the channel region in the semiconductor layers; and a source region formed of silicon so as to adjoin to the opposite side of the channel region in the source extension region, and a drain region formed of silicon so as to adjoin to the opposite side of the channel region in the drain extension region in the semiconductor layers.
US08124460B2 Integrated circuit package system employing an exposed thermally conductive coating
An integrated circuit package system includes providing a leadframe that is coplanar with a bottom surface of the integrated circuit package system to which is attached a device with a thermally conductive coating that is coplanar with the bottom surface of the integrated circuit package system to the leadframe, the device having the characteristics of being singulated from a wafer and the thermally conductive coating having the characteristics of being singulated from a wafer level thermally conductive coating and encapsulating the device with an encapsulation material that leaves the thermally conductive coating exposed for thermal dissipation.
US08124436B2 MEMS switch capping and passivation method
A MEMS switch with a platinum-series contact is capped through a process that also passivates the contact by controlling, over time, the amount of oxygen in the environment, pressures and temperatures. Some embodiments passivate a contact in an oxygenated atmosphere at a first temperature and pressure, before hermetically sealing the cap at a higher temperature and pressure. Some embodiments hermetically seal the cap at a temperature below which passivating dioxides will form, thus trapping oxygen within the volume defined by the cap, and later passivate the contact with the trapped oxygen at a higher temperature.
US08124431B2 Nitride semiconductor laser device and method of producing the same
A method of producing a nitride semiconductor laser device includes: forming a wafer including a nitride semiconductor layer of a first conductivity type, an active layer of a nitride semiconductor, a nitride semiconductor layer of a second conductivity type, and an electrode pad for the second conductivity type stacked in this order on a main surface of a conductive substrate and also including stripe-like waveguide structures parallel to the active layer; cutting the wafer to obtain a first type and a second type of laser device chips; and distinguishing between the first type and the second type of chips by automatic image recognition. The first type and the second type of chips are different from each other in position of the stripe-like waveguide structure with respect to a width direction of each chip and also in area ratio of the electrode pad to the main surface of the substrate.
US08124430B2 Method for forming quantum well structure and method for manufacturing semiconductor light emitting element
A method for forming a quantum well structure that can reduce the variation in the In composition in the thickness direction of a well layer and a method for manufacturing a semiconductor light emitting element are provided. In a step of forming a quantum well structure (active layer) by alternately growing barrier layers and well layers on a primary surface of a GaN substrate, the well layers are each formed by growing InGaN, the barrier layers are each grown at a first temperature, the well layers are each grown at a second temperature which is lower than that of the first temperature, and when the well layers are each formed, before a starting material gas for Ga (trimethylgallium) is supplied, a starting material gas for In is supplied.
US08124427B2 Method of creating an extremely thin semiconductor-on-insulator (ETSOI) layer having a uniform thickness
A method for creating an extremely thin semiconductor-on-insulator (ETSOI) layer having a uniform thickness includes: measuring a thickness of a semiconductor-on-insulator (SOI) layer at a plurality of locations; determining a removal thickness at each of the plurality of locations; and implanting ions at the plurality of locations. The implanting is dynamically based on the removal thickness at each of the plurality of locations. The method further includes oxidizing the SOI layer to form an oxide layer, and removing the oxide layer.
US08124424B2 Single molecule-format bioluminescent probe
The claimed invention comprises a single molecule-format bioluminescent probe for detecting a target-specific ligand in a living cell, which comprises, a ligand-binding molecule of which conformation is changed upon binding to the ligand, wherein the ligand-binding molecule comprises a ligand-binding domain (LBD) of a nuclear receptor and an LBD-interacting domain that is a co-activator peptide of said nuclear receptor, and an N-terminal polypeptide and a C-terminal polypeptide of a click beetle luciferase (N-CBLuc and C-CBLuc), which flank each end of the ligand-binding molecule, respectively, wherein the N-CBLuc and the C-CBLuc self-complement to generate a luminescent signal only upon binding of the ligand to the ligand-binding molecule.
US08124423B2 Method and apparatus for controlling the flow resistance of a fluid on nanostructured or microstructured surfaces
A method and apparatus is disclosed wherein the flow resistance of a droplet disposed on a nanostructured or microstructured surface is controlled. A closed-cell feature is used in a way such that, when the pressure of at least a first fluid within one or more of the cells of said surface is decreased to or below a desired level, a droplet disposed on that surface is caused to at least partially penetrate the surface. In another illustrative embodiment, the pressure within one or more of the cells is increased to or above a desired level in a way such that the droplet of liquid is returned at least partially to its original, unpenetrated position. In yet another embodiment, a closed-cell structure feature pattern is used to prevent penetration of the nanostructured or microstructured surface, even when the pressure of the fluid disposed on the surface is relatively high.
US08124422B2 Sample collection system and method
An apparatus or method for removing water and concentrating an analyte in solution, wherein the concentrated analyte sample is delivered directly to a vial, such as an autosampler vial that is capable of use in a gas chromatography autosampler.
US08124419B2 Gas sensor devices comprising organized carbon and non-carbon assembly
This invention relates generally to gas sensors comprising organized assemblies of carbon and non-carbon compounds. The invention also relates to devices containing such gas sensors and analysis units. In preferred embodiments, the organized assemblies of the instant invention take the form of nanorods or their aggregate forms. More preferably, a nanorod is made up of a carbon nanotube filled, coated, or both filled and coated by a non-carbon material.
US08124416B2 Selective and sensitive detection of mercuric ion by novel dansyl-appended calix[4] arene molecules, via fluorescence quenching
In particular, Compounds of Formula I or Formula II, generally known as calix[4]arenes, may be prepared. The compounds may be used to test samples for the presence of Hg2+ by fluorescence quenching. The compounds may also be used to selectively detect Hg2+ in samples containing other mono- or divalent metals.
US08124413B2 Thermocycler and sample port
The invention relates to continuous flow systems, in particular thermocyclers for the automated and continuous cycling of fluid between a plurality of temperature zones in the amplification of nucleic acids. The invention also relates to an improved sample port for introducing a volume of a liquid sample into a continuous flow system.
US08124408B2 Preparation of inactivated artificial antigen presenting cells and their use in cell therapies
Methods of processing inactivated artificial antigen presenting cells (aAPCs) and artificial antigen presenting cells with specificity for selected antigenic peptides are described, including their generation and use in cell therapy compositions comprising activated cytotoxic T lymphocytes. Inactivated aAPCs are advantageously generated through crosslinking, such as via a photoreaction involving a psoralen derivative and UVA irradiation.
US08124406B2 Method for modifying chromosomes
The present invention relates to a method for producing a modified foreign chromosome(s) or a fragment(s) thereof, which comprises the steps of: (a) preparing a microcell comprising a foreign chromosome(s) or a fragment(s) thereof, and transferring said foreign chromosome(s) or a fragment(s) into a cell with high homologous recombination efficiency through its fusion with said microcell; (b) in said cell with high homologous recombination efficiency, inserting a targeting vector by homologous recombination into a desired site of said foreign chromosome(s) or a fragment(s) thereof, and/or a desired site of a chromosome(s) derived from said cell with high homologous recombination efficiency, thereby marking said desired site; and (c) in said cell with high homologous recombination efficiency, causing deletion and/or translocation to occur at the marked site of said foreign chromosome(s) or a fragment(s) thereof.
US08124403B2 Tube ports and related container systems
A tube port includes a tubular first stem having an interior surface and an exterior surface extending between a first end and a longitudinally spaced apart second end. The interior surface bounds a passage that longitudinally extends through the first stem. The tube port also includes a flange encircling and radially outwardly projecting from the first end of the first stem. The flange and the first stem are integrally formed as a unitary member comprised of a flexible elastomeric material having a durometer on a Shore A scale with a value of less than 90.
US08124402B2 Encoded beads having oligonucleotides attached in arrays on a patterned surface
A method and apparatus for the manipulation of colloidal particles and biomolecules at the interface between an insulating electrode such as silicon oxide and an electrolyte solution. Light-controlled electrokinetic assembly of particles near surfaces relies on the combination of three functional elements: the AC electric field-induced assembly of planar aggregates; the patterning of the electrolyte/silicon oxide/silicon interface to exert spatial control over the assembly process; and the real-time control of the assembly process via external illumination. The present invention provides a set of fundamental operations enabling interactive control over the creation and placement of planar arrays of several types of particles and biomolecules and the manipulation of array shape and size. The present invention enables sample preparation and handling for diagnostic assays and biochemical analysis in an array format, and the functional integration of these operations. In addition, the present invention provides a procedure for the creation of material surfaces with desired properties and for the fabrication of surface-mounted optical components.
US08124396B2 Asparaginases and method of preparing a heat-treated product
The formation of acrylamide during heat treatment in the production of a food product is reduced by treating the raw material with an enzyme before the heat treatment. The enzyme is capable of reacting on asparagine or glutamine (optionally substituted) as a substrate or is a laccase or a peroxidase.
US08124394B2 Polypeptides having cellobiohydrolase II activity and polynuleotides encoding same
The present invention relates to isolated polypeptides having cellobiohydrolase activity and isolated polynucleotides encoding the polypeptides. The invention also relates to nucleic acid constructs, vectors, and host cells comprising the polynucleotides as well as methods of producing and using the polypeptides.
US08124392B2 Crystal structure of Aurora-2 protein and binding pockets thereof
The present invention provides crystalline molecules or molecular complexes which comprise binding pockets of Aurora-2 or its homologues. The invention also provides crystals comprising Aurora-2. The present invention also relates to a computer comprising a data storage medium encoded with the structural coordinates of Aurora-2 binding pockets and methods of using a computer to evaluate the ability of a compound to bind to the molecule or molecular complex. This invention also provides methods of using the structure coordinates to solve the structure of homologous proteins or protein complexes. In addition, this invention provides methods of using the structure coordinates to screen for and design compounds, including inhibitory compounds, that bind to Aurora-2 or homologues thereof.
US08124386B2 Methods and systems for biomass conversion to carboxylic acids and alcohols
The disclosure includes a method, process and apparatus for the conversion of biomass to carboxylic acids and/or primary alcohols. The system may include a pretreatment/fermentation subsystem operable to produce a fermentation broth containing carboxylic acid salts from biomass, such as lignocellulosic biomass. The system may also include a dewatering subsystem operable to remove excess water from the fermentation broth to produce a concentrated product. The system may also includes an acid springing subsystem operable to produce a mixed carboxylic acid product. The system may also include a hydrogenation subsystem operable to produce an alcohol mixture, such as a mixture containing primary alcohols. Methods of operating this system or other systems to obtain a carboxylic acid or alcohol mixture are also provided.
US08124384B2 Enhanced production of lipids containing polyenoic fatty acid by very high density cultures of eukaryotic microbes in fermentors
The present invention provides a process for growing eukaryotic microorganisms which are capable of producing lipids, in particular lipids containing polyenoic fatty acids. The present invention also provides a process for producing eukaryotic microbial lipids.
US08124382B2 Methods, microarray, and kits for detection of drug resistance genes in gram-negative bacteria
The present invention provides kits and microarrays containing primer pairs for amplifying drug resistance genes and/or probes for detection of drug resistance genes. Also provided are methods of detecting drug resistance genes using kits and microarrays described herein.
US08124378B2 Murine zcytor17 ligand polynucleotides
The present invention relates to zcytor17lig polynucleotide, polypeptide and anti-zcytor17 antibody molecules. The zcytor17lig is a novel cytokine. The polypeptides may be used within methods for stimulating the immune system, and proliferation and/or development of hematopoietic cells in vitro and in vivo. The present invention also includes methods for producing the protein, uses therefor and antibodies thereto.
US08124374B2 Method of producing recombinant protein
An object of the present invention is to provide a method of mass-producing recombinant protein by the liquid culture method with koji molds as host. According to the present invention, it is provided a method of producing recombinant protein by using the recombinant koji molds which are obtained by transforming koji molds as host comprising: culturing the recombinant koji molds in a liquid medium which contains as culture raw material at least one selected from the group consisting of the cereal of which surface is entirely or partly covered with at least husks, the bean and/or the tuber of which surface is covered with hulls and the amaranthus and/or the quinoa without pre-treatment such as grinding or crushing; and collecting the recombinant protein from the culture product.
US08124373B2 Isomaltulose synthases, polynucleotides encoding them and uses therefor
The invention is directed to novel enzymes that convert sucrose to isomaltulose. More particularly, the present invention discloses novel sucrose isomerases, polynucleotides encoding these sucrose isomerases, methods for isolating such polynucleotides and nucleic acid constructs that express these polynucleotides. Also disclosed are cells, including transformed bacterial or plant cells, and differentiated plants comprising cells, which contain these sucrose isomerase-encoding polynucleotides, as well as extracts thereof. Methods of producing isomaltulose are also disclosed which use the polypeptides, polynucleotides, cells, cell extracts and plants of the invention.
US08124372B2 Selective enzymatic amidation of C-terminal esters or acids of peptides
The present invention relates to a process for the amidation of C-terminal esters or acids of peptide substrates in solution-phase synthesis of peptides, comprising amidating one or more peptide substrates comprising C-terminal esters or acids using the protease subtilisin in any suitable form in the presence of an ammonium salt derived from an acid having a pKa above 0.This process is useful in the production of protected or unprotected peptides.
US08124371B2 Compositions and methods for destabilizing lysosomes to increase oncogenic or aberrant protein degradation
The present invention relates to compositions for destabilizing lysosomes to increase the degradation of oncogenic or aberrant proteins for the prevention or treatment of disease. Methods for identifying agents which destabilize lysosomes are also provided as are agents identified in accordance with the screening method.
US08124369B2 Method of cleaving DNA with rationally-designed meganucleases
Rationally-designed LAGLIDADG meganucleases and methods of making such meganucleases are provided. In addition, methods are provided for using the meganucleases to generate recombinant cells and organisms having a desired DNA sequence inserted into a limited number of loci within the genome, as well as methods of gene therapy, for treatment of pathogenic infections, and for in vitro applications in diagnostics and research.
US08124367B2 Device for applying a detector reagent to the skin for measuring cholesterol
The present invention provides a method and apparatus for non-invasive measurement of skin cholesterol. More particularly, one aspect of the invention provides for a device to apply a detector reagent to a selected area of skin. Another aspect of the invention provides for an indicator device to produce a visual change corresponding to the amount of detector reagent that is bound in the skin. The method and apparatus of this invention typically do not require any instrumentation for certain embodiments, allowing the invention to be suitable for self-testing, for example, but not limited to, in the home environment. As such the invention is particularly useful to allow individuals to assess their risk of atherosclerosis and related vascular diseases.
US08124366B2 Method for the determination of the formation of endothelins for medical diagnostic purposes, and antibodies and kits for carrying out such a method
The invention relates to an in vitro method for detecting the formation of endothelins during serious illnesses, especially cardiovascular diseases, inflammations, sepsis and cancer, in whole blood, plasma or serum of a human patient for medical diagnosis. Using this method, relatively long-lasting peptide fragments, especially a C-terminal peptide fragment, of the processed primary prepro- or proendothelins that contain neither the actual biologically active endothelin nor its direct precursor, big endothelin, can be detected.
US08124354B2 Method and immunoabsorbents for specific detection and absorption of antibodies associated with celiac disease and dermatitis herpetiformis
The present invention relates to fusion peptides that are derived from components of gliadin, to a method and reagents for the serological diagnosis of celiac disease or dermatitis herpetiformis by way of assaying antibodies that are directed against modified gliadin. The invention also relates to methods and pharmaceutical compositions for treating said diseases by specific immunoabsorption of these antibodies.
US08124352B2 Methods and compositions for targeting HEPSIN
Anti-HEPSIN monoclonal antibodies, and methods for using the antibodies, are provided.
US08124347B2 Photosynthetic hydrogen production from the green alga chlamydomonas reinhardth
The present invention relates generally to hydrogen production for use in fuel cells, foodstuffs and chemical production, and more particularly, to biologically and photosynthetically produced hydrogen. Specifically, disclosed is a method for producing bacteria and green alga that can produce hydrogen in quantities that exceed four hundred percent of the hydrogen produced by green alga in nature; thus, producing organisms which can serve as hydrogen generators for fuel cells, chemical production and numerous other applications.
US08124346B2 Annealing control primer and its uses
The present invention relates to an annealing control primer for improving annealing specificity in nucleic acid amplification and its applications to all fields of nucleic acid amplification-involved technology. The present primer comprises (a) a 3′-end portion having a hybridizing nucleotide sequence substantially complementary to a site on a template nucleic acid to hybridize therewith; (b) a 5′-end portion having a pre-selected arbitrary nucleotide sequence; and (c) a regulator portion positioned between said 3′-end portion and said 5′-end portion comprising at least one universal base or non-discriminatory base analog, whereby said regulator portion is capable of regulating an annealing portion of said primer in association with annealing temperature.
US08124344B2 Method of determining an amount of fatty acid contents in bovine intramuscular fat on the basis of genotype of fatty acid synthase gene and method of determining goodness of eating quality of beef on the basis of the results thereof
The present invention has an object to provide a method of determining fatty acid composition in intramuscular fat on the basis of bovine genotype, in particular a method of simply determining an amount of an oleic acid content with a high degree of accuracy, and a method of objectively determining the goodness of eating quality of beef on the basis of the results of the determination. The present invention provides a method of determining an amount of fatty acid content in bovine intramuscular fat on the basis of the genotype of fatty acid synthase determined by determining base <1> and/or base <2> described below, and a method of determining whether cattles are those from which beef with an excellent eating quality is obtained on the basis of the results thereof. <1> A 16,024th base corresponding to a polymorphic site which is either adenine (A) or guanine (G) in a base sequence represented by SEQ ID NO. 1 of a sequence list. <2> A 16,039th base corresponding to a polymorphic site which is either thymine (T) or cytosine (C) in the same base sequence.
US08124343B2 IRE-1α substrates
IRE-1α substrates useful for identifying agonists and antagonists of IRE-1α RNase activity.
US08124342B2 Methods for nucleic acid manipulation
A method for replicating and amplifying a target nucleic acid sequence is described. A method of the invention involves the formation of a recombination intermediate without the prior denaturing of a nucleic acid duplex through the use of a recombination factor. The recombination intermediate is treated with a high fidelity polymerase to permit the replication and amplification of the target nucleic acid sequence. In preferred embodiments, the polymerase comprises a polymerase holoenzyme. In further preferred embodiments, the recombination factor is bacteriophage T4 UvsX protein or homologs from other species, and the polymerase holoenzyme comprises a polymerase enzyme, a clamp protein and a clamp loader protein, derived from viral, bacteriophage, prokaryotic, archaebacterial, or eukaryotic systems.
US08124341B2 Genes and polypeptides relating to hepatocellular or colorectal carcinoma
The present application provides novel human genes WDRPUH and KRZFPUH, and PPIL1 whose expression is markedly elevated in a great majority of HCCs and colorectal cancers, respectively, compared to corresponding non-cancerous tissues, as well as novel human gene APCDD1 whose expression is elevated in primary colon cancers and down-regulated in response to the transduction of wild-type APC1 into colon-cancer cells. The genes and polypeptides encoded by the genes can be used, for example, in the diagnosis of a cell proliferative disease, and as target molecules for developing drugs against the disease.
US08124339B2 Assays and methods using biomarkers
Methods and assays examining expression of one or more biomarkers in a mammalian tissue or cell sample are provided. According to the disclosed methods and assays, detection of the expression of one or more such biomarkers is predictive or indicative that the tissue or cell sample will be sensitive to apoptosis-inducing agents such as Apo2L/TRAIL and anti-DR5 agonist antibodies. Certain biomarkers which may be examined include fucosyltransferases, in particular fucosyltransferase 3 (FUT3) and/or fucosyltransferase 6 (FUT6), as well as sialyl Lewis A and/or X antigens. Kits and articles of manufacture are also provided.
US08124337B2 Hereditary cataract status in canines based on HSF4 gene marker
The invention provides methods for assessing the Hereditary cataract (HC) status of a canine mammal, which methods comprise use of an HSF4 marker to assess the status. Preferred canine mammals are dogs selected from the following breeds: Staffordshire bull terrier, Boston terrier, French bulldog, Mastiff, Bulldog, Boxer, Bullmastiff, Miniature bull terrier.
US08124336B2 Methods and compositions for reducing the complexity of a nucleic acid sample
Aspects of the present invention are drawn to methods and compositions for sorting nucleic acid molecules into physically separate compartments according to the identity of a nucleotide base or sequence of bases at a specific location, resulting in the production of reduced complexity samples that find use in any number of downstream genetic analyses. Aspects of the methods of the invention include fragmenting a nucleic acid sample, e.g., with a restriction enzyme, ligating an adaptor (or adaptors), and sorting the fragments based on the identity of the nucleotide base(s) positioned adjacent to the fragmentation site (e.g., the restriction enzyme cut site/or recognition site). Each round of sorting produces binned samples having reduced complexity over the parent sample.
US08124334B2 Selective detection of oncogenic HPV
Compositions and methods for discriminately detecting the presence of a set of related genes from target organisms while avoiding detection of closely similar genes in non-target organisms. The present invention achieves this objective by a variety of novel nucleic acid constructs and methods. The nucleic acid constructs of the present invention are able to carry out this objective by virtue of the selected sequences of the compositions and by methods of use of such compositions.
US08124332B2 Methods of using sIP-10, CD26 inhibitors and CXCR3 levels in a sample to assess clearance of infection, response to interferon therapy, and treating chronic infections
The present invention relates to methods for the treatment of infection, a disease, or a condition using CD26 (DPIV) inhibitors. The present invention also relates to an antibody that binds to the IP-10 protein and a method of monitoring the necessity for administering a CD26 inhibitor to a patient, comprising evaluating a level of sIP-10, a activity of CD26, and/or a level of CXCR3 cells in a sample.
US08124331B2 In vitro method to detect bladder transitional cell carcinoma
The present invention refers to an in vitro method to detect a bladder transitional cell carcinoma, in an individual, to determine the stage or severity of this cancer in an individual or to monitor the effect of therapy administered to an individual with this cancer; to screen for, identify, develop and evaluate the efficacy of therapeutic compounds against this cancer in order to develop new medicinal products, and also agents that inhibit the expression and/or activity of the FGFR3 protein and/or the effects of this expression.
US08124329B2 Hypothermic preservation of biological tissues and cells
A method for hypothermic preservation of biological tissue for later recovery to a viable state includes flushing the biological tissue with a gas mixture of sulfur hexafluoride or xenon and oxygen. The sulfur hexafluoride or xenon is in a concentration in the mixture between about 75 mole percent to 95 mole percent. The method includes pressurizing the biological tissue, preferably isothermically, with the mixture to a pressure that will form clathrates inside the biological tissue at a desired storage temperature in a range of about +1° C. to about +5° C. The method includes a step of cooling the biological tissue, preferably isobarically, to the desired storage temperature. Optional steps for further cooling to no colder than about −20° C. and for depressurization are provided as well as steps for recovering the hypothermically preserved biological tissue to a viable state, preferably using a recovery gas mixture.
US08124328B2 Methods for imaging and processing positive-working imageable elements
An imaged and developed element, such as a lithographic printing plate, is provided by infrared radiation imaging of a positive-working imagable element having inner and outer imagable layers. One or both layers contain a polymeric binder having pendant 1H-tetrazole groups. The imaged element is developed with a single processing solution having a pH of from about 5 to about 11 to remove predominantly only the exposed regions and to provide a protective layer over the imaged surface.
US08124322B2 Method for manufacturing semiconductor device, and method for processing etching-target film
The present invention provides a method for processing an etching-target film, which can achieve both of a highly precise dry etching process and a reduction of LER. A method for processing an etching-target film, comprises: forming, in sequence from the bottom, an organic mask layer 40, a silicon-containing layer 50 and a resist layer 70, over an etching-target film; forming a predetermined pattern in the resist layer 70 by a photolithography process; etching the silicon-containing layer 50 through a mask of the resist layer 70 by employing a first etching gas; etching the organic mask layer 40 through a mask of the etched silicon-containing layer 50 by employing a second etching gas; and etching the etching-target film through a mask of the etched organic mask layer 40 by employing a third etching gas, wherein the first etching gas contains trifluoroiodomethane (CF3I).
US08124319B2 Semiconductor lithography process
A semiconductor lithography process. A photoresist film is coated on a substrate. The photoresist film is subjected to a flood exposure to blanket expose the photoresist film across the substrate to a first radiation with a relatively lower dosage. The photoresist film is then subjected to a main exposure using a photomask to expose the photoresist film in a step and scan manner to a second radiation with a relatively higher dosage. After baking, the photoresist film is developed.
US08124315B2 Optical recording medium
An optical recording medium contains a recording layer being composed of a phase-change recording material where at least four elements, Ga, Sb, Sn and Ge are contained and the transfer linear velocity is 20 m/s to 30 m/s, and when the wavelength of a recording/reproducing light is within the range of 650 nm to 665 nm and the recording linear velocity is 20 m/s to 28 m/s, the refractive index Nc and the extinction coefficient Kc in a crystalline state and the refractive index Na and the extinction coefficient Ka in an amorphous state in the recording layer respectively satisfy the following numerical expressions: 2.0≦Nc≦3.0, 4.0≦Kc≦5.0, 4.0≦Na≦5.0, and 2.5≦Ka≦3.1, and information is recordable at the range of 20 m/s to 28 m/s of recording linear velocity.
US08124312B2 Method for forming pattern, and material for forming coating film
A novel method for forming a pattern capable of decreasing the number of steps in a double patterning process, and a material for forming a coating film suitably used in the method for forming a pattern are provided. First resist film (2) is formed by applying a first chemically amplified resist composition on support (1), and thus formed film is selectively exposed, and developed to form multiple first resist patterns (3). Next, on the surface of the first resist patterns (3) are formed multiple coating patterns (5) by forming coating films (4) constituted with a water soluble resin film, respectively. Furthermore, a second chemically amplified resist composition is applied on the support (1) having the coating pattern (5) formed thereon to form second resist film (6), which is selectively exposed and developed to form multiple second resist patterns (7). Accordingly, a pattern including the coating patterns (5) and the second resist patterns (7) is formed on the support (1).
US08124309B2 Solvent-free emulsion process
A process for making a resin emulsion suitable for use in forming toner particles is provided. In embodiments, a suitable process includes melt mixing a resin in the absence of an organic solvent, optionally adding a surfactant to the resin, adding to the resin a basic agent and water, and subjecting the resin, basic agent and water to acoustic mixing at a suitable frequency to form an emulsion of resin particles. In embodiments, the resin emulsion thus produced may be utilized to form a toner.
US08124308B2 Toner, vessel with the toner, developer, image forming apparatus and process cartridge and image forming method
Toner and a developer which are excellent in cleaning property and fixing property at low temperature, and capable of forming images with high quality are provided, along with a method for their production. A toner producing method involves dispersing and/or emulsifying an oil phase or a monomer phase containing a toner composition and/or a toner composition precursor in a water-based medium to granulate,wherein the toner has an average circularity of 0.925 to 0.970, and the toner composition and/or the toner composition precursor has a layered inorganic material in which at least a part of interlayer ions in the layered inorganic material has been exchanged with organic ions.
US08124302B2 Optical component for EUVL and smoothing method thereof
The present invention provides a method for smoothing an optical surface of an optical component for EUVL. Specifically, the present invention provides a method for smoothing an optical surface of an optical component for EUVL made of a silica glass material containing TiO2 and comprising SiO2 as a main component with a laser having an oscillation wavelength, to which the optical component for EUVL has an absorption coefficient of 0.01 μm−1 or more, at a fluence of 0.3 to 1.5 J/cm2 in an atmosphere having a water vapor partial pressure of 3.6 mmHg or less.
US08124301B2 Gradated photomask and its fabrication process
The invention provides a gradated photomask for reducing photolithography steps and its fabrication process, which make use of a generally available photomask blank, prevents the reflectance of a light shield film from growing high, makes alignment easy during the formation of a semitransparent film, and enables the semi-transparent film on a light shield pattern with good step coverage. A photomask (100) comprises a mixture of a light shield area including a light shield film (114) having a desired pattern on a transparent substrate wherein a film forming the pattern is substantially opaque to photolithographic light, a semitransparent film (113) that transmits the photolithographic light at a desired transmittance, and the light shield film (114) and the semitransparent film (113) are stacked on the transparent substrate (101) in that order; a semi-transparent area wherein there is only the semitransparent film (113); and a transmissive area there is neither the light shield film (114) nor the semitransparent film (113), and is characterized in that the semitransparent film (113) has an antireflection function with respect to the photolithographic light.
US08124294B2 Polymer electrolyte membrane comprising inorganic nanoparticle bonded with proton-conducting group and solid acid, fuel cell including the same, and method of preparing the polymer electrolyte membrane
Provided is a polymer electrolyte membrane including an inorganic nanoparticle bonded with a proton-conducting group, a solid acid and a proton-conducting polymer. The inorganic nanoparticle bonded with the proton-conducting group may be obtained by reacting a compound including a proton-conducting group with a metal precursor. The polymer electrolyte membrane has significantly enhanced proton conductivity and reduced methanol crossover.
US08124291B2 Fuel cell system and control method thereof
In a fuel cell system, mixture fuel having a certain fuel concentration is supplied to an anode, electric power is output from between the anode and the cathode due to electrochemical reaction when the cathode makes contact with air, and unreacted fuel containing unreacted fuel is discharged from the anode. A fuel circulating path for circulating the unreacted fuel to the anode is connected to the power generating unit and fuel is supplied from the fuel supplying unit to the fuel circulating path depending on a reduction in pressure of the mixture fuel. The temperature of the power generating unit is controlled according to the concentration of the mixture fuel supplied to the anode. Consequently, a fuel cell system, which can achieve reduction of the size thereof without dropping fuel usage efficiency, can be provided.
US08124289B2 Multistage combustor and method for starting a fuel cell system
A multistage combustor is configured for starting a fuel cell system, and includes a partial oxidation (POX) burner having an inlet for receiving a flow of a fuel/oxidant mixture, the POX burner being configured to partially oxidize fuel in the fuel/oxidant mixture to yield a partially oxidized gas; a first output coupled to the fuel cell system and configured to provide a first amount of the partially oxidized gas as first output gas to a first fuel cell system component; a second burner coupled to the POX burner, the second burner being configured to receive a second amount of the partially oxidized gas from the POX burner and to oxidize at least some remaining fuel to yield a second output gas different from the first output gas; and a second output coupled to a second fuel cell system component and configured to provide the second output gas to the second fuel cell system component.
US08124284B2 Nonaqueous electrolytic solution containing additive for increasing capacity of lithium-ion cell and lithium-ion cell using same
Disclosed are an additive for improving charge/discharge characteristics of a lithium-ion cell, a nonaqueous electrolytic solution containing the additive, and a lithium-ion cell using the additive and/or the nonaqueous electrolytic solution. The additive serves as a solvent for a fluorine resin, such as poly(vinylidene fluoride), which is incorporated as an adhesive in a positive electrode containing a lithium-transition metal oxide capable of absorbing and releasing lithium and a negative electrode containing a carbon material capable of absorbing and releasing lithium. The additive comprises three compounds selected, respectively, from a 2-pyrrolidinone compound group, a cyclic alkyl compound group, and a cyclic pentanone compound group.
US08124277B2 Binder for electrode formation, slurry for electrode formation using the binder, electrode using the slurry, rechargeable battery using the electrode, and capacitor using the electrode
Disclosed is a binder for electrode formation, which is obtained by dispersing a polyolefin resin containing 50 to 98% by mass of an unsaturated hydrocarbon having 3 to 6 carbon atoms and 0.5 to 20% by mass of an unsaturated carboxylic acid unit in an aqueous medium together with a basic compound. This binder for electrode formation is also characterized in that the content of a nonvolatile water-compatibilizing agent is 5 parts by mass or less per 100 parts by mass of the polyolefin resin.
US08124276B2 Battery structure, assembled battery, and vehicle mounting these thereon
A bipolar battery includes: a bipolar electrode composed, by forming a positive electrode active material layer 12 an one surface of a current collector and forming a negative electrode active material layer 13 on the other surface; and a separator 14 composed to be stacked alternately with the bipolar electrode, wherein, in a single cell layer 15 composed by including the positive electrode active material layer 12, the separator 14 and the negative electrode active material layer 13, which are adjacent to one another, a thickness of the separator 14 is 0.68 times or more to less than 1.0 times a thickness of the positive electrode active material layer 12, and is 0.68 times or more to less than 1.0 times a thickness of the negative electrode active material layer 13.
US08124273B2 Nonaqueous electrolyte solution and lithium secondary battery using same
The present invention provides a nonaqueous electrolytic solution exhibiting excellent electrical capacity, long-term cycle property, and storage property in a charged state; and a lithium secondary battery using the nonaqueous electrolytic solution.The nonaqueous electrolytic solution in which an electrolyte salt is dissolved in a nonaqueous solvent, comprises 0.001% to 5% by weight of a tin compound represented by the following general formula (I) and/or (II), on the basis of the weight of the nonaqueous electrolytic solution: R1R2R3Sn-MR4R5R6  (I) where R1 to R3 each represent a hydrogen atom, a halogen atom, an alkyl group, an alkenyl group, an alkynyl group, an aryl group, or an aryloxy group; R4 to R6 each represent a hydrogen atom, a halogen atom, an alkyl group, an alkenyl group, an alkynyl group, or an aryl group; M represents Si or Ge; and SnX2  (II) where X represents β-diketonate.
US08124267B2 Lithium secondary battery having partitioned electrolyte
A lithium secondary battery is provided. Electrolytes of the lithium secondary battery are divided between an anode and a cathode into a plurality of regions not to contact with each other, thereby limiting movement paths of lithium ions. In this way, the lithium secondary battery inhibits growth of dendrite and improves energy density. Also, the lithium secondary battery that has a partition wall structure reduces leakage even when liquid electrolytes are used and actively copes with pressure applied to the battery.
US08124266B2 Electric storage device
An electric storage device is provided with a battery cell, a collector foil having a first metal plate and a second metal plate laminated together, and a voltmeter for measuring potential difference between the first metal plate and the second metal plate. The first metal plate and the second metal plate are formed of mutually different metals. The collector foil is arranged to be in contact with the battery cell.
US08124265B2 Power storage device
A power storage device includes: an electrolyte layer; and an electrode consisted of a current collecting portion and an electrode layer, wherein the thickness of the electrolyte layer is larger at a first position in a plane perpendicular to the stacking direction than at a second position where the heat radiation is higher than at the first position, and the thickness of the current collecting portion is smaller at a position corresponding to the first position than at a position corresponding to the second position.
US08124258B2 Glass substrate for magnetic disk
There is provided a glass substrate for a magnetic disk in which a maximum height of bumps forming a roughness pattern at a period of smaller than 2 μm is 6 nm or lower in an annular area having a width of 30 μm on a main surface on which a magnetic recording area is formed, a number of bumps having a height of 3 nm or higher in a unit area having a circular arc length of 30 μm within the annular area is one or less, and a difference in arithmetic average roughness between unit areas within the annular area is 0.2 nm or smaller.
US08124254B2 Heterostructure of ferromagnetic and ferroelectric materials with magneto-optic and electro-optic effects
A heterostructure of multiferroics or magnetoelectrics (ME) was disclosed. The film has both ferromagnetic and ferroelectric properties, as well as magneto-optic (MO) and electro-optic (EO) properties. Oxide buffer layers were employed to allow grown a cracking-free heterostructure a solution coating method.
US08124250B2 Organic electronic device
An organic electronic device includes: a pair of electrodes, an organic film layer containing an organic substance having a benzothiadiazole skeleton, a metal oxide layer provided on the organic film layer by vacuum vapor deposition, and an interface formed between the pair of electrodes out of the organic film layer and the metal oxide layer.
US08124249B2 Materials for organic electroluminescent devices
The present invention relates to novel materials which can be used in organic electronic devices, in particular electroluminescent devices, and are derivatives of fused aromatic systems.
US08124248B2 Light-emissive polymer blends and light-emissive devices made from the same
A polymer blend comprising a first, light-emissive polymer comprising substituted or non-substituted units according to formulae (I) and (II) and a second, hole transport polymer comprising substituted or non-substituted fluorene units according to formula (I) and substituted or non-substituted triarylamine units, wherein the molecular weights of the first and second polymers and the blending ratio of the first and second polymers are selected such that, in use in a light-emissive device, the luminance of the emitted light at a bias of 5V is no less than 20,000 cd/m2. wherein R′ is independently in each occurrence H, C1-C20 hydrocarbyl or C1-C20 hydrocarbyl containing one or more S, N, O, P or Si atoms, C4-C16 hydrocarbyl carbonyloxy, C4-C16 aryl(trialkylsiloxy) or both R′ may form together with the 9-carbon on the fluorene ring a C5-C20 cycloaliphatic structure containing one or more heteroatoms of S, N or O.
US08124247B2 High-strength welded steel pipe including weld metal having high cold-cracking resistance and method for manufacturing the same
A high-strength steel pipe has a tensile strength of 800 MPa or more and includes a weld metal having high cold-cracking resistance and high low-temperature toughness, wherein the weld metal contains C: 0.04% to 0.09% by mass, Si: 0.32% to 0.50% by mass, Mn: 1.4% to 2.0% by mass, Cu: less than 0.5% by mass, Ni: more than 0.9% by mass but not more than 4.2% by mass, Mo: 0.4% to 1.5% by mass, Cr: less than 0.5% by mass, V: less than 0.2% by mass, and the remainder of Fe and incidental impurities, and CS values calculated from the weld metal components using the equation CS=5.1+1.4[Mo]−[Ni]−[Mn]−36.3[C] are equal to zero or more at both an internal surface and an external surface.
US08124246B2 Coated components and methods of fabricating coated components and coated turbine disks
Coated components and methods of fabricating coated components and coated turbine disks are provided. In an embodiment, by way of example only, a coated component includes a substrate comprising a superalloy in an unmodified form and a coating disposed over the substrate, where the coating comprises the superalloy in a modified form. The modified form of the superalloy includes, by weight, at least 10% more chromium and at least 10% more of one or more noble metals than the unmodified form of the superalloy, and the modified form of the superalloy is substantially free of aluminum.
US08124237B2 Coated article with low-E coating including tin oxide interlayer
A coated article is provided which may be heat treated thermally tempered) in certain instances. In certain example embodiments, an interlayer of or including a metal oxide such as tin oxide is provided under an infrared (IR) reflecting layer so as to be located between respective layers comprising silicon nitride and zinc oxide. It has been found that the use of such a tin oxide inclusive interlayer results in significantly improved mechanical durability, thermal stability and/or haze characteristics.
US08124234B2 Polyurethane compositions and articles prepared therefrom, and methods for making the same
The invention provides a composition comprising the following: at least one olefin-based polymer, at least one halogenated ethylene-based polymer, or at least one elastomer rubber; at least one thermoplastic polyurethane; and at least one polydiene- or polydiol-based polyurethane. These compositions are well-suited for promoting the adhesion between polar (for example, polyester, polycarbonate and polylactic acid) and non-polar materials and for the manufacture of, among other things, films, fibers, sheets and tie layers, tubes, adhesives, dispersions, protective apparel, footwear, coatings, laminates and foams.
US08124233B2 Anti-reflection film, and polarizing plate and image display device using the same
An anti-reflection film, which comprises: a low refractive index layer that is formed by curing a coating solution composition comprising: a fluorine-free copolymer containing a constituent having a polysiloxane structure represented by formula (1) as defined in the specification in a main chain and a constituent containing a hydroxyl group in a side chain; and a fluorine-containing copolymer; a polarizing plate wherein the anti-reflection film is used as one of two protective films for a polarizing film; and an image display device wherein the anti-reflection film or the polarizing plate is used in the outermost surface of the display.
US08124231B2 Dust suppressants
The present application is directed to an article comprising a dusty surface and a coating on the dusty surface comprising a coating polymer having a Tg less −20° C. and a method of reducing dust. In some embodiments, the polymer has a Tg less than −30° C., and in specific embodiments, the polymer has a Tg less than −45° C. The dusty surface may be, for example, crushed stone, coal, iron ore, gravel, sand or other aggregates (e.g. a roofing granule,) or a soil surface.Generally, the coating polymer comprises a polyacrylate, polyurethane, synthetic and natural rubber, silicone and other organic polymers. In specific embodiments, the coating polymer comprises an acrylic emulsion polymer.
US08124229B2 Method for producing water-absorbent polymer particles with a higher permeability by polymerising droplets of a monomer solution
A process for preparing water-absorbing polymer beads with high permeability by polymerizing droplets of a monomer solution in a gas phase surrounding the droplets, wherein the monomer solution comprises at least 0.5% by weight of a crosslinker, based on the monomer, the polymerization in the droplet takes place in homogeneous phase, and the polymer beads have a mean diameter of at least 150 μm.
US08124227B2 Carbon nanofibers and procedure for obtaining said nanofibers
The object of the present invention is carbon nanofibers mainly characterized by their high specific volume of mesopores, their high gas adsorption capacity and presenting a graphitic hollow structure. A second object of this invention is a procedure for obtaining such carbon nanofibers, which makes use of a metallic nickel catalyst and specific process furnace parameters that combined with the chemical composition of the furnace atmosphere and the fluidodynamic conditions of the gas stream inside the furnace, result in a faster growth of the carbon nanofibers and also in a higher quality of the carbon nanofibers obtained.
US08124220B2 Inkjet recording element
An ink jet recording element having very good dye keeping properties in time. The recording element comprises a support and at least one ink-receiving layer, the ink-receiving layer comprising at least one hydrosoluble binder and at least one aluminosilicate polymer obtained by a preparation method consisting in treating an aluminum halide with a mixture of at least one silicon alkoxide only having hydrolyzable substituents and at least one silicon alkoxide having a non-hydrolyzable substituent, with an aqueous alkali in the presence of silanol groups, the aluminum concentration being maintained less than 0.3 mol/l, the Al/Si molar ratio being maintained between 1 and 3.6 and the alkali/Al molar ratio being maintained between 2.3 and 3; and then stirring the resulting mixture at a temperature of from 15° C. to 35° C. in the presence of silanol groups for long enough to form the hybrid aluminosilicate polymer.
US08124219B2 Resin panel and manufacturing method therefor
A resin panel for an automobile includes a skin layer formed on sides of a package tray along the direction of the thickness of the package tray and both surfaces of the package tray substantially orthogonal to the sides. An expanded layer is formed in an inner part of the package tray surrounded by the skin layer having voids by enlarging the volume of the cavity of a mold assembly during molding of the package tray to expand a thermoplastic resin in the cavity. Hollow ribs are formed of solid layers in the expanded layer to extend along the surfaces, each have a hollow formed inside over the entire length so that ends of the hollow rib continue out to the skin layer at the opposed sides of the panel. Openings in communication with the hollow rib are formed through the skin layer at the opposed sides, respectively.
US08124218B2 Microfabricated elastomeric valve and pump systems
A method of fabricating an elastomeric structure, comprising: forming a first elastomeric layer on top of a first micromachined mold, the first micromachined mold having a first raised protrusion which forms a first recess extending along a bottom surface of the first elastomeric layer; forming a second elastomeric layer on top of a second micromachined mold, the second micromachined mold having a second raised protrusion which forms a second recess extending along a bottom surface of the second elastomeric layer; bonding the bottom surface of the second elastomeric layer onto a top surface of the first elastomeric layer such that a control channel forms in the second recess between the first and second elastomeric layers; and positioning the first elastomeric layer on top of a planar substrate such that a flow channel forms in the first recess between the first elastomeric layer and the planar substrate.
US08124214B2 Fault tolerant transport mechanism in storage and method of controlling the same
A method of controlling a transport mechanism allows a first mobile carrier to move based on a power source incorporated in the first mobile carrier when an instructions signal specifying an access to a cell defined in a storage is supplied to a controller. When a fault is detected in the first mobile carrier, the first mobile carrier is moved based on the action of a second mobile carrier. The method ensures the movement of the first mobile carrier with the assistance of the second mobile carrier even when the first mobile carrier suffers from a fault. The first mobile carrier can be moved out of the movable range of the second mobile carrier. The second mobile carrier is allowed to move in the own movable range without an interference to the first mobile carrier. The second mobile carrier keeps operating without an interruption.
US08124212B2 Sputtering target and manufacturing method therefor, and recordable optical recording medium
To provide a sputtering target for preparing a recordable optical recording medium characterized by comprising Bi and B and a manufacturing method thereof, a recordable high density optical recording medium using the sputtering target, and a sputtering target which is capable of improving a speed of the film formation for the improvement of productivity, which has a high intensity at the time of the film formation and which has a heightened packing density.
US08124206B2 Sulfur-containing cycloaliphatic compound, filled sulfur-vulcanizable elastomer composition containing sulfur-containing cycloaliphatic compound and articles fabricated therefrom
A sulfur-containing cycloaliphatic compound, useful as a crosslinker for filled sulfur-vulcanizable elastomer compositions, is represented by the general formula: G[-CaH2a—S[C(═O)]bR]n wherein G is selected from the group consisting of: saturated, monocyclic aliphatic group of valence n containing from 5 to 12 carbon atoms and optionally containing at least one halogen, and saturated monocyclic silicone [RsiO—]n[R2SiO—]p group of valence n; wherein each R independently is a hydrogen or monovalent hydrocarbon of up to 20 carbon atoms; each occurrence of subscripts a and b independently is an integer wherein a is 2 to 6 and b is 0 or 1; p is an integer of from 0 to 3; and, n is an integer of from 3 to 6, with the provisos that when b is 0, R is a hydrogen atom, and when G is a non-halogenated, saturated monocyclic aliphatic group of 6 carbon atoms, n cannot be 3.
US08124205B2 Decorated ferrule and golf club using the same
A ferrule includes a brilliant three-dimensional decoration member fixed to a surface of the ferrule.
US08124200B2 Food packaging
Food packaging is described herein that is capable of being heated inductively to thereby heat one or more food products.
US08124196B2 Fluorobicyclo[2.2.2]octane compound, method of producing the same, and applications thereof
A liquid crystal composition comprising at least one compound having a fluorobicyclo[2.2.2]octane skeleton represented by formula (I) below is disclosed. A fluorobicyclo[2.2.2]octane compound represented by formula (II) below is also disclosed. In the formulae, Y represents a hydrogen atom or fluorine atom.
US08124192B2 Layer application device for an electrostatic layer application of a building material in powder form and device and method for manufacturing a three-dimensional object
A device and a method for applying powder onto an application surface has a powder container (35) and a voltage source (32) for applying a voltage between the powder container and the application surface, wherein the powder container (35) at least partially consists of a conductive material and the powder container (35) has an opening (35a) or is completely open at its side facing the application surface when the voltage is applied.
US08124190B2 Method for discharging liquid material, method for manufacturing color filter, and method for manufacturing organic EL element
A method for discharging a liquid material includes performing a scan by moving a discharge target having a film formation area and a plurality of nozzles forming a nozzle row with respect to each other, and discharging a liquid material as droplets from the nozzles onto the film formation area by selectively applying one of drive waveforms generated using time division to an energy generation element of each of the nozzles in synchronization with the scan. The discharging of the liquid material includes applying a first drive waveform to a first nozzle of the nozzle row and a second drive waveform having a different discharge timing from the first drive waveform to a second nozzle of the nozzle row with the second nozzle being adjacent to the first nozzle, and changing a combination of the first and second drive waveforms selected from the drive waveforms at least once.
US08124188B2 Polymeric coatings and methods for forming them
The present invention relates to a controllable polymeric surface coating including a macromolecule, which is covalently bound to the surface of a substrate, the macromolecule including a plurality of polymerization initiators and a plurality of surface binding groups; and pendant polymers grafted from at least some of the polymerization initiators.
US08124186B2 Method of forming a shelf liner
A shelf liner (10) with a natural appearance includes a skid-resistant first major surface and a decorative second major surface. The shelf liner includes a scrim (12) and a foamed resin (14), which is in contact with the scrim. The resin leaves at least a portion of the scrim exposed on the second major surface.
US08124183B2 Fast drying emulsion systems
The drying time for aqueous asphalt emulsions used in the roofing and other waterproofing industries is shortened by separately applying an emulsion breaking agent to the substrate to be waterproofed, to the aqueous asphalt emulsion after it is applied, or both.
US08124176B2 Polymer-assisted deposition of films
A polymer assisted deposition process for deposition of metal nitride films and the like is presented. The process includes solutions of one or more metal precursor and soluble polymers having binding properties for the one or more metal precursor. After a coating operation, the resultant coating is heated at high temperatures under a suitable atmosphere to yield metal nitride films and the like. Such films can be conformal on a variety of substrates including non-planar substrates. In some instances, the films can be epitaxial in structure and can be of optical quality. The process can be organic solvent-free.
US08124162B2 Pea protein composition
The invention relates to a pea protein whose protein content is equal to or greater than 60% by dry weight, preferably ranging from 60 to 95% by weight, a molecular weight distribution profile is of 1.0-1.8%, preferably of 1.5-3.0% of proteins of greater than 100 000 Da, preferably 20-55% of proteins greater than 15 000 and 100 000 Da, 15-30% of proteins of greater than 5 00 and 15 00 Da and 25-50%, preferably 25-45% of proteins greater than 5 000 Da and whose soluble protein content determined by a method for measuring the protein solubility in water ranging from 20 to 85%, preferably 25 to 65%.
US08124160B2 Method for reducing acrylamide formation in thermally processed foods
A process and apparatus for a method for reducing the amount of acrylamide in thermally processed foods. This invention permits the production of foods having significantly reduced levels of acrylamide. The method relies on the manipulation of various unit operations used in the production of food products, particularly the washing and cooking unit operations. For example, the washing unit operation can be modified to provide a contacting step at an increased time and temperature, and adding components such as calcium chloride and L-cysteine to an aqueous solution used for the contacting. The cooking unit operation can be modified by dividing it into at least a higher-temperature first heating step and a lower-temperature second heating step in order to avoid the high-temperature/low-moisture conditions most favorable for acrylamide formation.
US08124159B2 Method of making bean curd using rice
The present invention relates to a method of making bean curd using rice in which 65-70 wt % of soya beans and 30-35 wt % of parched rice in about a total weight of 5 kg for one block of bean curd are soaked, and in which the soya beans are soaked for about 8-12 hours and the parched rice is soaked for about 2 hours in water. The soya beans and parched rice are then mixed and ground into a powder with the addition of 15 g of a defoaming agent and 60 g of water. Bean curd refuse is filtered by passing the mixture through a filter, and then the remaining parched rice/soya bean milk is boiled at 80-99° C. Water and 42 g of magnesium chloride added to the heated parched rice/bean curd milk, 14 g of salt or JukYum (salt roasted in bamboo) is added and the mixture is coagulated. The coagulated mixture is then mashed to a diameter or 3-4 cm and then pressed. Accordingly, consumers' health can be improved by the bean curd containing rice, and it is possible to satisfy various tastes of the consumers by providing high-quality bean curd.
US08124157B2 Noodles and noodle skins comprising soybean protein composition and the method of making same
It is intended to prepare noodles and noodle skins, in particular, wheat flour-free noodles and noodle skins, which comprise a soybean protein composition at a high ratio. By adding a water-extracted less denatured soybean protein to noodles and noodle skins, noodles and noodle skins containing a large amount of the soybean protein can be obtained. Further, it is possible to obtain wheat flour-free noodles and noodle skins and starch-free noodles and noodle skins.
US08124148B2 Method of obtaining smoked food products with marks and product thus obtained
The present invention basically consists of printing proofing marks on a film, placing it in contact with a food product, followed by an intense drying at low relative moisture and a smoking step which also occurs at low relative moisture for obtaining areas having a more smoked color in the food product under the proofing marks than in the areas not protected by said proofing marks.
US08124145B2 Sugar alcohol sanded chewing gum and process for making same
A chewing gum comprising a solid shaped chewing gum composition sanded with a sugar alcohol having a negative heat of solution and a method of mixing same. The method involves coating solid pieces of chewing gum composition with a wetting syrup and sanding the wetted pieces with sugar alcohol crystals. The chewing gum is characterized by intense initial cooling and flavor release.
US08124144B2 Method of producing blood type checking reagent containing lectin
Lectin is extracted from seeds of bitter gourd (also known as balsam pear or Momordica charantia). A blood type checking reagent for checking a blood type includes the lectin. The lectin extracted from seeds of bitter gourd preferably has a molecular weight between 100,000 and 170,000 measured with polyacrylamide gel electrophoresis in existence of sodium dodecyl sulfate (SDS-PAGE). A method of checking a blood type includes the steps of: extracting lectin from seeds of bitter gourd (also known as balsam pear or Momordica charantia); preparing a blood type checking reagent containing the lectin; and checking a blood type using the blood type checking reagent.
US08124137B2 Composition for prevention and/or treatment of tumors containing acacia bark derivative
It is intended to provide a composition which is useful in preventing or treating a tumor. The composition is a composition for the prevention and/or treatment of a tumor, containing an acacia bark derivative.
US08124136B2 Tablet with remedial composition and methods for treating medical disorders and ailments
The invention discloses a pharmaceutical composition useful for treatment and prevention of medical disorders and ailments. The aforesaid composition comprises active ingredients comprising; Turmeric extract, Turmeric powder, optionally, Selenium or source of Selenium, especially Selenomethionine, optionally, Green tea extract. The pharmaceutical composition further comprises enteric coating encapsulating the same. The disclosed pharmaceutical composition is especially adapted for treatment of inflammatory bowel disease (IBD) and colorectal cancer (CRC).
US08124132B2 Method and composition for inhibition of microbial growth in aqueous food transport and process streams
The present invention relates to compositions including peroxyacetic acid and peroxyoctanoic acid and methods for preventing microbial growth in aqueous streams including the step of applying a composition of the invention to the stream. The compositions and methods can control microbial growth in aqueous streams used for transporting or processing food products.
US08124127B2 Hydrophobic cross-linked gels for bioabsorbable drug carrier coatings
Coatings for medical devices, methods of making the coatings, and methods of using them are described.
US08124124B2 Compressed tablet formulation comprising non-steroidal anti-inflammatory drugs and methods
A compressed tablet composition comprising: a granular component comprising a plurality of solidified melt granules of a non-steroidal anti-inflammatory drug (NSAID) having a melting point in the range 30-300° C. and incorporating a disintegrant uniformly dispersed therein; characterised in that the granules comprise a continuous phase of said non-steroidal anti-inflammatory drug and further characterised in that the tablet composition comprises silicon dioxide present in an amount of 0.05-5.0% by weight of the composition. Preferably, the composition also contains an extra-granular component comprising the silicon dioxide and a lubricant. Further preferably the NSAID is ibuprofen which has a melting point in the range 75-77° C. Optionally the melting process can be carried out in an extruder. Tablets containing advantageous processing properties and dissolution characteristics are obtained.
US08124121B2 Flavors, flavor modifiers, tastants, taste enhancers, umami or sweet tastants, and/or enhancers and use thereof
The present invention relates to the discovery that certain non-naturally occurring, non-peptide amide compounds and amide derivatives, such as oxalamides, ureas, and acrylamides, are useful flavor or taste modifiers, such as a flavoring or flavoring agents and flavor or taste enhancer, more particularly, savory (the “umami” taste of monosodium glutamate) or sweet taste modifiers, —savory or sweet flavoring agents and savory or sweet flavor enhancers, for food, beverages, and other comestible or orally administered medicinal products or compositions.
US08124120B2 Crosslinked hyaluronic acid compositions for tissue augmentation
Disclosed are hyaluronic acid (HA) compositions including crosslinked, water-insoluble, hydrated HA gel particles. Also disclosed are methods of making the HA compositions, and methods of using the HA composition to augment tissue in a subject.
US08124117B2 One step fire ant control
The present invention relates to a method for controlling fire ants with a single step application of a combination of a bait and a controlled release treatment composition, and to the novel bait/controlled release treatment composition combination used in the method of the present invention.
US08124115B2 Alcoholic pump foam
An alcoholic foam composition, which can be dispensed as a foam via a pump-foam system contains a) at least 52 to ≦99 wt % of an alcohol or mixture of alcohols, b) a surfactant or a surfactant mixture, c) at least one polyalkylene glycol, d) optionally, at least one foam stabilizer, e) optionally, at least one member selected from the group consisting of cosmetic auxiliaries, adjuvants, active ingredients, and mixtures thereof, and f) optionally water. The surface tension of component b) lies in the range of ±15 dyn/cm of the surface tension of component a) or corresponds to the surface tension of component a), and the sum of components a) to f) is 100 wt % relative to the total quantity of the foam composition.
US08124114B2 Fragranced polymer with malodor counteractant
A malodor counteractant composition comprising beads of a water absorbent polymer and an aromachemical comprising at least two aldehydes. Optional ingredients include a solvent for the aromachemical and one or more surfactants.
US08124109B2 Vault compositions for immunization against chlamydia genital infection
Methods and compositions are provided herein for immunizing a subject against Chlamydial genital infection by administering to the subject an effective amount of a Chlamydial immunogenic peptide or an immunogenic fragment or variant thereof incorporated within a vault-like particle carrier. In some aspects, the vault-like-particles are administered to the nasal mucosa. The methods and compositions advantageously exhibit enhanced ability to induce cell-mediated immunity and/or antibody-based immunity at mucosal surfaces while reducing inflammation associated with Chlamydia infection.
US08124108B2 Polypeptides for inducing a protective immune response against Staphylococcus epidermidis
The present invention features polypeptides comprising an amino acid sequence structurally related to SEQ ID NO: 1 and uses of such polypeptides. SEQ ID NO: 1 is a truncated derivative of a full-length S. epidermidis polypeptide. The full-length naturally occurring polypeptide is referred to herein as full-length ORF1319e. A His-tagged derivative of SEQ ID NO: 1 was found to produce a protective immune response against S. epidermidis.
US08124106B2 Virus purification methods
Provided is a method for purifying a virus from a host cell, the method comprising: a) culturing host cells, b) infecting the host cells with a virus, c) treating the cell culture with nuclease, and d) lysing the host cells to provide a lysate comprising the virus. The virus may be recombinant adenovirus. Further provided are methods for purifying a recombinant virus expressing a heterologous protein capable of binding nucleic acid, comprising: a) culturing host cells, b) infecting the host cells with recombinant virus, c) lysing the host cells to provide a lysate comprising the recombinant virus, d) subjecting the recombinant virus to anion exchange chromatography and size exclusion chromatography, wherein the virus-containing mixture is buffer exchanged at least once with a solution comprising at least 2 M NaCl, or another salt providing an equivalent ionic strength.
US08124105B2 Compositions, methods and kits relating to poxvirus subunit vaccines
The invention is directed to a poxvirus vaccine comprising a soluble truncated poxvirus envelope protein. The invention is also directed to a vaccine comprising a nucleic acid encoding such proteins. Also included is an antibody which specifically binds to the proteins and nucleic acid encoding the same, as well as methods of preventing and treating a poxvirus infection using the afore-mentioned vaccine, antibody, protein, and nucleic acid encoding them.
US08124103B2 Influenza antigens, vaccine compositions, and related methods
The present invention relates to the intersection of the fields of immunology and protein engineering, and particularly to antigens and vaccines useful in prevention of infection by influenza virus. Provided are recombinant protein antigens, compositions, and methods for the production and use of such antigens and vaccine compositions.
US08124102B2 Method for the reduction of viral loads in patients comprising the administration of nef-deficient human immunodeficiency virus (HIV)
A therapeutic suspension for the treatment of human immunodeficiency virus type I (HIV-1) infection in humans using isolated and purified HIV-1 nef-deficient viral particles having a nef-deletion between the endonuclease cleavage sites Nco I and Xho I.
US08124100B2 Inactivated nodavirus vaccine
A vaccine against nodavirus infection in fish can be produced by inactivating the virus using an aziridine compound. This vaccine can be used to prevent Viral Nervous Necrosis (VNN) in a variety of fish species.
US08124097B2 Hybrid and chimeric polypeptides that regulate activation of complement
A hybrid complement-regulating protein comprises a first functional unit of a first complement regulatory protein having complement regulating properties, a first spacer sequence of at least about 200 amino acids encoding a polypeptide that does not exhibit complement regulating properties and at least a second functional unit attached to the spacer sequence. The second functional unit may be a polypeptide providing a functional unit of a second complement regulatory protein, a polypeptide derived from an immunoglobulin, or a polypeptide that enhances binding of the protein to an animal cell. The hybrid protein may also contain a second spacer sequence and a third functional unit of a complement regulatory protein, a polypeptide derived from an immunoglobulin, and a polypeptide that enhances binding of the protein to an animal cell. The optional third functional unit may be the same or different from the first or second functional units.
US08124095B2 Fusion proteins for delivery of erythropoietin to the CNS
The invention provides compositions, methods, and kits for increasing transport of a neurotrophin (e.g., erythropoietin (EPO)) across the blood brain barrier while allowing its activity to remain substantially intact. The neurotrophin (e.g., EPO) is transported across the blood brain barrier via one or more endogenous receptor-mediated transport systems.
US08124093B2 Human cytomegalovirus neutralizing antibodies and use thereof
The invention relates to neutralizing antibodies, and antibody fragments thereof, having high potency in neutralizing hCMV, wherein said antibodies and antibody fragments are specific for one, or a combination of two or more, hCMV gene UL products. The invention also relates to immortalized B cells that produce, and to epitopes that bind to, such antibodies and antibody fragments. In addition, the invention relates to the use of the antibodies, antibody fragments, and epitopes in screening methods as well as in the diagnosis, prevention, and therapy of disease.
US08124087B2 Methods of controlling bone loss by inhibiting DKK1
The present invention is drawn to understanding lytic bone diseases. In this regard, the present invention discloses mechanism by which Wnt signaling antagonist inhibits bone differentiation. Also disclosed herein are methods to control bone loss, treat bone disease and prevent tumor growth in bones of individual.
US08124086B2 Antibodies that bind cell-associated CA 125/O772P and methods of use thereof
The present invention provides antibodies, and antigen-binding fragments of antibodies, fusion polypeptides and analogs that preferentially bind cell-associated CA 125/O772P polypeptides relative to shed CA 125/O772P polypeptides. The present invention further provides methods of preventing, managing, treating or ameliorating one or more symptoms associated with a CA 125/O772P-related disorder. In particular, the present invention provides methods of preventing, managing, treating, or ameliorating one or more symptoms associated with a cell proliferative disorder, such as cancer, e.g., ovarian cancer. The present invention still further provides methods for diagnosing a CA 125/O772P-related disorder or predisposition to developing such a disorder, as well as methods for identifying antibodies, and antigen-binding fragments of antibodies, that preferentially bind cell-associated CA 125/O772P polypeptides relative to shed CA 125/O772P polypeptides.
US08124084B2 Compositions and methods for immunomodulation in an organism using IL-15 and soluble IL-15Ra
The present invention relates to a therapeutic polypeptide and methods for its creation and use for modulating an immune response in a host organism in need thereof. In particular, the invention relates to the administration to an organism in need thereof, of an effective amount of a pre-coupled polypeptide complex comprising a lymphokine polypeptide portion, for example IL-15 (SEQ ID NO: 5, 6), IL-2 (SEQ ID NO: 10, 12) or combinations of both, and an interleukin receptor polypeptide portion, for example IL-15Ra (SEQ ID NO: 7, 8), IL-2Ra (SEQ ID NO: 9, 11) or combinations of both, for augmenting the immune system in, for example, cancer, SCID, AIDS, or vaccination; or inhibiting the immune system in, for example, rheumatoid arthritis, or Lupus. The therapeutic complex of the invention surprisingly demonstrates increased half-life, and efficacy in vivo.
US08124082B2 Humanized anti-beta7 antagonists and uses therefor
The invention provides therapeutic anti-beta7 antibodies, compositions comprising, and methods of using these antibodies.
US08124080B2 Human monoclonal antibody having fat-reducing effect
A purified polypeptide having an amino acid sequence that is substantial identical with the amino acid sequence of SEQ ID NO:1, SEQ ID NO:3, or both, in which the polypeptide binds low density lipoproteins (LDL) or oxidized LDL (oxLDL), or both, and particularly binds well to LDL cholesterol and oxidized LDL cholesterol. The polypeptide may be used in combination with conventional adjuvants or carrier substances for producing a drug having a fat-reducing effect and for producing drugs for aiding in the treatment of renal diseases.
US08124079B2 Anti-IGF-IR antibodies and uses thereof
The present invention relates to novel antibodies capable of binding specifically to the human insulin-like growth factor I receptor IGF-IR and/or capable of specifically inhibiting the tyrosine kinase activity of said IGF-IR, especially monoclonal antibodies of murine, chimeric and humanized origin, as well as the amino acid and nucleic acid sequences coding for these antibodies. The invention likewise comprises the use of these antibodies as a medicament for the prophylactic and/or therapeutic treatment of cancers overexpressing IGF-IR or any pathology connected with the overexpression of said receptor as well as in processes or kits for diagnosis of illnesses connected with the overexpression of the IGF-IR. The invention finally comprises products and/or compositions comprising such antibodies in combination with anti-EGFR antibodies and/or anti-VEGF antibodies and/or antibodies directed against other growth factors involved in tumor progression or metastasis and/or compounds and/or anti-cancer agents or agents conjugated with toxins and their use for the prevention and/or the treatment of certain cancers.
US08124078B2 Method for treating idiopathic thrombocytopenic purpura using monoclonal antibodies
The invention concerns a method for obtaining and selecting monoclonal antibodies by an ADDC-type test, said antibodies capable of activating type III Fcγ receptors and having a particular glycan structure. The inventive anti-D antibodies can be used for preventing Rhesus isoimmunization in Rh negative persons, in particular for haemolytic disease in a new-born baby or for uses such as idiopathic thrombocytopenic purpura (ITP).
US08124076B2 Single chain antibodies against β-amyloid peptide
Anti-AβP scFvs and single domain antibodies were generated, and when these antibodies were displayed on filamentous phage or as soluble protein molecules, stabilized by the maltose binding protein, they could prevent the fibrilization of Abp 1-40 and disaggregate Abp 1-40 fibrils generated in vitro. The anti-Aβp scFv antibodies also stained amyloid neuritic plaques on slices from transgenic mice. The anti-AβP scFv and single domain antibodies can be used for inhibiting or treating Alzheimer's disease.
US08124075B2 Enhanced biological autologous tissue adhesive composition and methods of preparation and use
The invention includes a composition useful for preparing a tissue sealant for use on a patient, comprising: autologous fibrinogen, an activating agent and at least one supplement. The invention includes a method of treating a disc having at least one defect, comprising: introducing a composition into the disc, wherein the composition comprises autologous fibrinogen and an activating agent, and wherein the composition forms fibrin.
US08124068B2 Recombinant intracellular pathogen immunogenic compositions and methods of use
Immunogenic compositions comprising recombinant attenuated intracellular pathogens that have been transformed to express recombinant immunogenic antigens of the same or other intracellular pathogens are provided. Exemplary immunogenic compositions include, but are not limited to attenuated recombinant Mycobacteria expressing the major extracellular non-fusion proteins of Mycobacteria and/or other intracellular pathogens. Other embodiments are provided wherein the recombinant attenuated intracellular pathogen is auxotrophic.
US08124065B2 Cytokine Protein Family
The present invention relates to polynucleotide and polypeptide molecules for zcyto20, zcyto21, zcyto22, zycto24, and zcyto25 proteins which are most closely related to interferon-α at the amino acid sequence level. The receptor for this protein family is a class II cytokine receptor. The present invention includes methods of reducing viral infections and increasing monocyte counts. The present invention also includes antibodies to the zcyto20 polypeptides, and methods of producing the polynucleotides and polypeptides.
US08124063B2 Method for moisturizing human skin using dihydroxypropyltri(C1-C3 alkyl) ammonium salts
A personal care product is provided which includes a composition containing dihydroxypropyltri(C1-C3 alkyl)ammonium salt in a carrier. The composition is packaged for delivery to a consumer and includes instructions printed on or associated with the packaging indicating topical use of the composition on skin, hair or the oral mucosae. Particularly useful is dihydroxypropyltrimonium chloride which operates as a humectant to moisturize both at high and low relative humidity environments.
US08124060B2 Compositions containing a bimodal film former and cross-linked starch
The invention relates to compositions containing (a) at least one bimodal film former; and (b) at least one cross-linked starch as well as to methods of using such compositions and kits containing such compositions.
US08124059B2 Stabilized aqueous aluminum zirconium solutions
The present invention describes a method and compositions by which introducing PO4−3 ion at particular stage in the preparation of aluminum/zirconium solutions surprisingly results in significantly improved zirconium molecular weight stability.
US08124053B2 Compositions comprising chitin microparticles and their medical uses
The present invention relates to compositions comprising chitin microparticles and their medical uses, and in particular to compositions for use as vaccines which comprise antigen from an infectious agent, a chitin microparticle preparation, and a further adjuvant.
US08124052B2 Method for identifying targeting domains and methods and compositions comprising the same
The present invention is directed to a method of identifying tissue targeting domains. In particular, the invention relates to methods for identifying a polynucleotide encoding a targeting domain which directs tumor cell localization to secondary sites, to methods of utilizing the polynucleotide and corresponding polypeptide or fragments thereof and compositions comprising the same.
US08124045B2 Method of selective purification of armchair carbon
The present invention provides a method of selectively extracting metallic armchair carbon nanotubes alone from the mixture of carbon nanotubes of mixed chiralities, wherein vacant lattice defects are removed from armchair carbon nanotubes alone using the fact that the vacant lattice defects of zigzag carbon nanotubes are hard to diffuse in the axial direction of nanotubes compared with those of armchair carbon nanotubes. Since vacant lattice defects remaining on zigzag carbon nanotubes are active, the tube structures are easily destroyed and decomposed by oxidation etc. Thus it is possible to extract armchair carbon nanotubes alone from the mixture of carbon nanotubes of mixed chiralities.
US08124044B2 Carbon nanotubes, a method of preparing the same and an element using the same
Carbon nanotubes, a method for preparing the same and an element using the same are provided. The method for preparing carbon nanotubes includes synthesizing carbon nanotubes from carbon source using an arc-discharge method in the presence of catalysts and promoter, wherein the promoter contains an element capable of reducing the surface energy of carbon nanotubes. Carbon nanotubes with high purity and narrow diameter distribution can thus be prepared.
US08124042B2 Nonwovens bonded with acrylamide/N-alkylolacrylamide crosslinking mixture with C2-C10 alkylol
An aqueous dispersion includes a self-crosslinking alkylolacrylamide containing interpolymer, the interpolymer being prepared in an emulsion polymerization medium by way of interpolymerizing in the medium: (a) acrylamide monomer; (b) N—C2 to C10 alkylolacrylamide monomer, wherein the molar ratio of acrylamide:N—C2 to C10 alkylolacrylamide interpolymerized is at least 0.5; and (c) at least one or more additional ethylenically unsaturated monomers added to the medium in an amount of from about 80 weight % to about 98 weight % based on the dry weight of monomer interpolymerized in the medium. The dispersions are particularly useful as binders for fibrous webs.
US08124041B2 Process for producing silicon
A process for producing silicon comprises the steps of a reduction step [1] of depositing silicon by reacting chlorosilanes and hydrogen in a reactor under heat and discharging an exhaust gas that contains hydrogen, oligomers of silanes, and a silicon powder; a carring step [2] of carrying the exhaust gas that has been exhausted in the step [1] while keeping a temperature of the exhaust gas at not less than 105° C.; a removal step [3] of supplying the exhaust gas that has been carried in the step [2] to a filter at a temperature of not less than 105° C. and discharging the exhaust gas from the filter at a temperature of not less than 105° C. to remove the silicon powder from the exhaust gas and give a mixed gas that contains the hydrogen and the oligomers of silanes; and a separation step [4] of cooling the mixed gas that has been obtained in the step [3] to separate the hydrogen as a gas phase from the mixed gas.
US08124040B1 Methods of making silane compositions
A method of making hydrogenated Group IVA compounds having reduced metal-based impurities, compositions and inks including such Group IVA compounds, and methods for forming a semiconductor thin film. Thin semiconducting films prepared according to the present invention generally exhibit improved conductivity, film morphology and/or carrier mobility relative to an otherwise identical structure made by an identical process, but without the washing step. In addition, the properties of the present thin film are generally more predictable than those of films produced from similarly prepared (cyclo)silanes that have not been washed according to the present invention. The present invention advantageously provides semiconducting thin film structures having qualities suitable for use in electronics applications, such as display devices or RF ID tags, while enabling high-throughput manufacturing processes that form such thin films in seconds or minutes, rather than hours or days as with conventional photolithographic processes.
US08124039B2 Process of silicon tetrafluoride gas synthesis
A process of producing silicon tetrafluoride from fluoride containing feedstocks. The process calcines the fluoride containing feedstock and a silica containing feedstock before reacting the mixture with sulfuric acid to produce silicon tetrafluoride. The silicon tetrafluoride is scrubbed with sulfuric acid. Excess sulfuric acid is recycled to the process. The process demonstrates an economic and environmentally friendly way to produce high quality silicon tetrafluoride.
US08124035B2 Process and apparatus for alkylation of aromatic compound with aliphatic mono-olefin compound of 8 to 18 carbon atoms
Continuous processes for monoalkylating aromatic compound with an aliphatic feedstock comprising aliphatic olefin of 8 to 18 carbon atoms per molecule are effected using at least 3 reaction zones in series, each containing solid alkylation catalyst with effluent cooling between reaction zones, each of which reaction zones is supplied a portion of the fresh aliphatic feedstock, such that the Reaction Zone Delta T in each reaction zone is less than about 15° C. The overall aromatic compound to olefin molar ratio is less than about 20:1. The alkylation product has desirable linearity and low amounts of dimers, dealkylated compounds and diaryl compounds even though a low aromatic compound to olefin molar ratio is used.
US08124034B2 Alkylation unit and method of modifying
One exemplary embodiment can be a method of modifying an alkylation unit to increase capacity. The method may include combining a first alkylation zone with a second alkylation zone. Generally, the first alkylation zone includes a first settler having a height and a width. Typically, the width is greater than the height. In addition, the second alkylation zone may have a second settler having a height and a width. Usually, the height is greater than the width.
US08124032B2 Microfluidic device and method of using same
The invention relates to a microfluidic device comprising one or more fluid channels, one or more fluid ports, and a V-shaped particle retention structure. The fluid channel is generally opposite the particle retention structure, fluid ports are located between the fluid channel and the particle retention structure, and the particle retention structure has sloped side walls. Fluid, including reagents, can be delivered to the microfluidic device through the one or more fluid channels or the fluid ports. The invention also relates to methods of using the microfluidic device to monitor, observe, measure, or record a biological parameter of a particle, to separate a single particle from a group of particles, to culture a cell, to treat a particle, and to move a particle back and forth in the device.
US08124030B2 Microfluidic device having regulated fluid transfer between elements located therein
A centrifugal microfluidic device includes a substrate configured for rotation about an axis, the substrate having a start chamber disposed therein, the start chamber configured to hold a liquid. The device includes an output chamber disposed in the substrate and located radially outward of the start chamber. A fluid transfer channel connects the start chamber to the output chamber. A ventilation channel connects the output chamber to the start chamber, the ventilation channel connecting at one end to a radially inward portion of the start chamber and at an opposing end to a junction point on the output chamber. A vent hole is provided in the substrate that is operatively connected to the output chamber. The location of the junction between the ventilation channel and the output chamber is located radially outward with respect to the level of fluid in the start chamber so as to prevent cross-contamination.
US08124025B2 Membrane system for blood coagulation testing
Articles for testing a coagulation process in whole blood.
US08124024B2 Cassette for sample preparation
A cassette for preparing a sample is disclosed herein. The cassette includes a housing, which encloses the structures and the processes used to prepare the sample.
US08124020B2 Apparatus for preventing metal catalyzed coking
A process and apparatus is described in which a sulfiding agent is added to a catalytic conversion reactor to prevent metal catalyzed coking. The catalytic reactor may be downstream from a first fluid catalytic cracking reactor that provides C10— hydrocarbons as feed to the downstream catalytic reactor.
US08124017B2 Systems and methods for high efficiency regenerative selective catalytic reduction
The invention provides a system for regenerative selective catalytic reduction including a catalyst chamber that contains a catalyst for reducing NOX in a gas stream passing therethrough. The system also includes a reactant injector, first and second heat exchangers, and a valve manifold adapted to direct a substantially continuous gas stream through the heat exchangers and catalyst chamber in such a manner as to flow through the catalyst chamber in the same flow direction during each cycle of the system. The invention also provides a process of regenerative selective catalytic reduction wherein the gas stream through the catalyst chamber flows in the same flow direction during each cycle of the process.
US08124016B2 Articles with antimicrobial property and manufacturing method thereof
The present invention discloses an article with an antimicrobial property, and a manufacturing method thereof which gives the antimicrobial property to a surface of the article in which bacteria or viruses may contact to proliferate themselves. The antimicrobial property is obtained by coating Kimchi lactic acid bacteria culture fluid with a wide antibacterial spectrum singly or in combination with nano metal particles on the surface of the article.
US08124015B2 Multiplexed, microfluidic molecular assay device and assay method
Microfluidic systems are disclosed, including microfluidic devices and methods, useful for simultaneously analyzing multiple analytes in each of a plurality of distinct nanoliter-volume samples.
US08124013B1 System and method for large scale atmospheric plasma generation
A plasma generating system and a method of generating a plasma on a surface is provided. A surface-wave medium is laminated to a surface for propagating electromagnetic surface waves. The surface-wave medium includes a dielectric and a metallic pattern on the dielectric for increasing an inductive reactance of the surface-wave medium. The plasma generating surface further includes a microwave power source. A coupler couples the microwave power source to the surface-wave medium. A plurality of field enhancement points are located on the surface-wave medium. The plurality of field enhancement points include microwave resonant structures that couple to the electromagnetic surface waves.
US08124009B2 Method of aeration disinfecting and drying grain in bulk and pretreating seeds and a transverse blow silo grain dryer therefor
Aeration drying and disinfecting grain crops in bulk and pretreating seeds includes passing through a bulk of grain crops and seeds disinfecting and drying agents including an ozone and air mixture and surrounding air, subdividing the disinfecting and drying agents into a plurality of streams spaced from one another in a vertical direction, and passing the streams at different heights through levels located at corresponding heights of the bulk of grain crops and seeds transversely in a substantially horizontal direction.
US08124008B2 Free cutting steel
A low carbon free cutting steel can be obtained by allowing the steel to contain 0.02 to 0.15 mass % of C, 0.05 to 1.8 mass % of Mn, 0.20 to 0.49 mass % of S, more than 0.01 mass % and not more than 0.03 mass % of O, 0.3 to 2.3% of Cr, and the balance consisting of Fe and inevitable impurities, the Cr/S ratio falling within a range of between 2 and 6.
US08124005B2 Process and apparatus for producing sponge iron
A process and an apparatus for producing sponge iron from iron-oxide-containing material in lump form by direct reduction in a reduction shaft using a reducing gas, wherein the entire reducing gas is introduced by means of a number of reducing gas distribution ducts in a star-like arrangement or arranged parallel to one another, preferably into the lower quarter of the reduction shaft, and evenly distributed over the entire cross-section of the reduction shaft.
US08124003B2 Method and apparatus for remote controlling monitoring and/or servicing heat-treatment equipment via wireless communications
A method and apparatus provide for remote control, monitoring and/or servicing of heat-treatment equipment via wireless communications networks. Specifically, the method and apparatus can be used in pre and post-weld heat-treatment applications for steel pipes in a variety of industries, including, but not limited to, power plants, chemical and petrochemical plants and refineries. Importantly, the embodiment generates and manages all the documentation necessary to input and verify the specified heat-treatment process. It will produce and deliver to the customer the reports and certificates required by the applicable quality control standards, requirements and regulatory authorities.
US08124002B2 Extrusion-molding machine, extrusion-molding method, and method for manufacturing honeycomb structured body
An extrusion-molding machine according to the present invention comprises: a screw having a blade portion for extruding a molding material, the screw disposed in a tightly-closed space; and a die for molding an extruded molding material, wherein the space is maintained in a reduced-pressure atmosphere, and a high-hardness coat layer is formed at least on the blade portion.
US08124000B2 Substrate manufacturing method including protrusion removing step
A method for removing and modifying a protrusion by using a short pulse laser is provided for modifying a color filter. In a color filter modifying method, a transparent substrate (2) is scanned with a beam in a parallel direction, while irradiating a protrusion (8) generated on the color filters (3-1, 3-2, 3-3) formed on a transparent substrate (2) with a beam collected by a high NA condensing lens (18), and a protrusion (8) is removed or modified.
US08123998B2 Injection molding method and injection molding die
An injection molding method for a plate-shaped resin substrate, wherein a through-hole whose diameter gradually becomes smaller from one surface to the other surface is provided thereon and fine flow path that connects to the through-hole is provided on the other surface. A cavity is formed by joining one molding die forming one surface with the other molding die forming the other surface. A part of the one molding die that forms the through-hole includes a taper pin that protrudes from the one molding die toward the other molding die. The substrate is formed by filling the cavity with resin material, and the substrate is released from the other molding die by separating the one molding die from the other molding die. By pushing the inner wall of the through-hole with the taper pin projected further toward the other molding die, the substrate is released from the one molding die.
US08123996B2 Wrinkle control for composite tubes
In one step of a method of fabricating a composite tube, layers of uncured composite material may be laid over a surface. In another step, spaced-apart strips of at least one of uncured, partially cured, and completely cured composite material may be laid lengthwise over the laid layers of composite material. In still another step, the spaced-apart strips may be compacted against the layers of uncured composite material. In an additional step, the compacted spaced-apart strips and the layers of uncured composite material may be further consolidated and/or cured to form a composite tube.
US08123994B2 Method of making catheter including a unibody distal guidewire port
Methods and devices incorporating a guidewire entry port subassembly for use in rapid exchange catheters. The use of a subassembly allows for stronger quality control and simpler fabrication of a rapid exchange device. In several embodiments, methods of making a molded guidewire entry port using a mold, often in conjunction with one or more mandrels, are disclosed. Several device embodiments include a separate molded guidewire port as well as molded guidewire ports which are attached, during a molding step, to segments of a catheter.
US08123992B2 Process of forming multilayered structures
The present invention provides for a method of producing an integral multilayered porous membrane by simultaneously co-casting a plurality of polymer solutions onto a support to form a multilayered liquid sheet and immersing the sheet into a liquid coagulation bath to effect phase separation and form a porous membrane. The support can be a temporary support or form an integrated support for the membrane. The plurality of layers may be of the same polymer or different, same concentration or viscosity or different and may be subjected to the same processing conditions or different ones to form unique structures.
US08123990B2 Method for producing fiber composite
The object of the present invention is to provide a method for producing a fiber composite excellent in lightweight and rigidity. The present method is one for producing fiber composite having a structure in which reinforcing fibers are bonded with a thermoplastic resin, is characterized in that said reinforcing fiber is at least one of a plant fiber and an inorganic fiber, and comprises a feeding process in which a thermally expandable capsule (20) having a shell wall composed of a thermoplastic resin is fed to one of either front side or back side of a mat (10a) comprising the reinforcing fiber and a thermoplastic resin fiber, a dispersing process in which one side of the mat is subjected to vibration from another side of the mat while pressing the one surface side of the mat (10a) to disperse the capsule (20) towards another side of the mat, a melting process in which the thermoplastic resin fiber constituting the mat is molten, and an expanding process in which the capsule (20) dispersed in the mat is heated to expand.
US08123989B2 Method and device for controlling a linear motion axis
The invention relates to a method and device for controlling a linear motion axis, particularly of the injection screw (43) or a melt piston for an injection molding machine. Said device comprises a hydraulically driven piston (45) having a piston chamber (A) and a rod chamber (B). According to the solution proposed by the invention, at least one process phase is controlled/regulated by means of two parallel proportional valves, an injection valve (1) and a metering valve (2). The two proportional valves can be connected in parallel or in combination. The control/regulation of the driven piston (45) preferably uses digital technology. An enormous reduction in energy consumption and smooth transitions between the process phases are achieved with a hydraulic linear drive.
US08123976B2 Alkaline aqueous solution composition used for washing or etching substrates
As a washing liquid and an etching solution for semiconductor substrates and glass substrates, alkaline aqueous solutions are used; however, since metal impurities are adsorbed on the substrate surface during processing, a next process for removing the adsorbed metal impurities is required. In addition, when a washing liquid is used, it cannot wash off metal impurities; therefore an acid washing process is required. The present invention provides an aqueous solution composition, which is an alkaline aqueous solution but is able to prevent adsorption of metal impurities, which also has cleaning capability.By means of an alkaline aqueous solution composition used for washing or etching a substrate, the composition comprising a chelating agent represented by the general formula (1): and an alkaline component, the adsorption of metal impurities on the substrate is prevented, and metal impurities adsorbed on the substrate are washed off.
US08123975B2 Methods of preventing frost formation and facilitating the removal of winter precipitation relative to a windshield and compositions for use therein
Disclosed herein is a winter precipitation barrier composition, comprising: a retaining agent, a solvent, and optionally, an auxiliary component, such as a rheology/viscosity modifier, surfactant, detergent, foaming/defoaming additive, humectant, dye, colorant, fragrance, or a combinations thereof. In one embodiment, the retaining agent comprises a primarily hydrophobic monomer or a hydrophilic monomer.
US08123973B2 Method of manufacturing magnetic material
A method of manufacturing magnetic material is described hereinafter. Firstly, Fe(NO3)3.9H2O and other metal nitrate compounds are dissolved in an alcohol solvent to form a mixed solution. Secondly, the mixed solution is heated to 60˜100 degrees Centigrade. Next, citric acid is added into the mixed solution for being reacted with each other under the temperature of 60˜100 degrees Centigrade so that can make the alcohol solvent volatilized and further obtain brown solid powder. Lastly, the solid powder is further heated for a period of time so as to obtain the magnetic material having a fluffy powdery form.
US08123972B2 Sheet-like soft-magnetic material and production method thereof
The present invention is to impart, to a sheet-like soft magnetic material, a configuration in which sheet thickness change is suppressed and in which fluctuation in magnetic permeability is small even under a high-temperature or a high-temperature, high-humidity environment, even when a plurality of thin curable soft magnetic sheets produced by a coating method are laminated. The sheet-like soft magnetic material is formed from a soft magnetic composition which is formed by mixing at least a flat soft magnetic powder, an acrylic rubber, an epoxy resin, a curing agent for the epoxy resin, and a solvent. The flat soft magnetic powder is arranged in an in-plane direction of the sheet-like soft magnetic material. An acrylic rubber having a glycidyl group is used for the acrylic rubber. The weight ratio of the flat soft magnetic powder with respect to the total amount of the acrylic rubber, the epoxy resin, and the curing agent for the epoxy resin is 3.7 to 5.8.
US08123971B2 Magnetorheological elastomers (MREs) with polynorbornene as a carrier medium, processes for producing such elastomer composites and their use
The invention relates to composites made of an elastic carrier medium comprising polynorbornene (PNR) and magnetisable particles which are polarized reversibly in a magnetic field. Thus the mechanical properties, such as e.g. storage modulus G′ (describes the elastic behavior or the energy storage) and loss modulus G″ (describes the viscous behavior or the energy dissipation), of such elastomer composites can be increased rapidly and reversibly within wide limits (up to approx. two orders of magnitude) as a function of an external magnetic field. Wide-ranging application possibilities are produced herefrom, e.g. for adaptive damping systems, in which the damping force can be adjusted via the strength of the magnetic field.
US08123970B2 Potassium monopersulfate solutions
A composition comprising a solution of potassium monopersulfate having an active oxygen content of from about 3.4% to about 6.8% and a process for its preparation including neutralization with an alkaline material is disclosed.
US08123968B2 Multiple deposition for integration of spacers in pitch multiplication process
Pitch multiplication is performed using a two step process to deposit spacer material on mandrels. The precursors of the first step react minimally with the mandrels, forming a barrier layer against chemical reactions for the deposition process of the second step, which uses precursors more reactive with the mandrels. Where the mandrels are formed of amorphous carbon and the spacer material is silicon oxide, the silicon oxide is first deposited by a plasma enhanced deposition process and then by a thermal chemical vapor deposition process. Oxygen gas and plasma-enhanced tetraethylorthosilicate (TEOS) are used as reactants in the plasma enhanced process, while ozone and TEOS are used as reactants in the thermal chemical vapor deposition process. The oxygen gas is less reactive with the amorphous carbon than ozone, thereby minimizing deformation of the mandrels caused by oxidation of the amorphous carbon.
US08123965B2 Interconnect structure with stress buffering ability and the manufacturing method thereof
An interconnect structure with stress buffering ability is disclosed, which comprises: a first surface, connected to a device selected form the group consisting of a substrate and an electronic device; a second surface, connected to a device selected form the group consisting of the substrate and the electronic device; a supporting part, sandwiched between and interconnecting the first and the second surfaces while enabling the areas of the two ends of the supporting part to be small than those of the first and the second surfaces in respective; and a buffer, arranged surrounding the supporting part for absorbing and buffering stresses.
US08123964B2 Image sensor and method for fabricating the same
An image sensor and a method for fabricating the same are provided. The image sensor includes a first conductive type substrate including a trench formed in a predetermined portion of the first conductive type substrate, a second conductive type impurity region for use in a photodiode, formed below a bottom surface of the trench in the first conductive type substrate, and a first conductive type epitaxial layer for use in the photodiode, buried in the trench.
US08123961B2 Extensions of self-assembled structures to increased dimensions via a “bootstrap” self-templating method
Methods for fabricating sublithographic, nanoscale arrays of openings and linear microchannels utilizing self-assembling block copolymers, and films and devices formed from these methods are provided. Embodiments of the invention use a self-templating or multilayer approach to induce ordering of a self-assembling block copolymer film to an underlying base film to produce a multilayered film having an ordered array of nanostructures that can be removed to provide openings in the film which, in some embodiments, can be used as a template or mask to etch openings in an underlying material layer.
US08123957B2 Method and apparatus of submersible intake equipment
An apparatus having flotation ballasts, a flotation platform and on the flotation platform, an intake equipment, such as a screen, check valve and/or pump intake and a coupling for a discharge pipe. In an embodiment of the present invention comprises, there are a plurality of substantially symmetrical flotation ballasts, each having a ballast chamber. The composition of the flotation ballast may be made of a material having a density appropriate for the fluid in which it is to be submerged. The method includes the steps of using an apparatus as herein described to ascend and descend intake equipment.
US08123951B2 Process and apparatus for simulated moving bed separation comprising bypass lines in every other bed and with controlled flushing flow rates during injections and withdrawals
A process for separating a feed F by simulated moving bed adsorption in a SMB device comprises external bypass lines Li/i+1 which directly connect two successive plates, Pi, Pi+1, the index “i” being either even or (exclusive of the foregoing) odd, along the whole length of the column, allowing said plates to be flushed, in which each of the bypass lines Li/i+1 comprises automated means for regulating the flow rate in the bypass lines, the bypass lines in certain cases being subject to a flushing flow during injection or withdrawal operations.
US08123950B2 Process and apparatus for simulated moving bed separation comprising bypass lines in every other bed and with a modulated bypass fluid flow rate
A process for separating a feed F by simulated moving bed adsorption in a SMB device is described, the device comprising external bypass lines Li/i+1 which directly connect two successive plates Pi, Pi+1, the index i being either even or (exclusive of the foregoing) odd, along the whole length of the column, in order to flush said plates, in which each of the bypass lines Li/i+1 comprises automated means for regulating the flow rate in the bypass lines, the degree of opening of said regulating means being defined by the following three rules: a) establishing a flow rate corresponding to an oversynchronicity in the range 15% to 30% in all of the open bypass lines of zone 1; b) establishing a flow rate corresponding to the synchronicity to within plus or minus 8% in all of the open bypass lines of zones 2 and 3; c) establishing a flow rate corresponding to an oversynchronicity in the range 20% to 40% in all of the open bypass lines of zone 4.
US08123948B2 Biomimetic water membrane comprising aquaporins used in the production of salinity power
The present invention provides methods for producing salinity power using pressure retarded osmosis and a biometric membrane (e.g., a liquid bilayer membrane or a lipid membrane containing multiple bilayers of fused deposited lipid vesicles) containing aquaporin water channels. The invention also provides power plants for producing salinity energy using pressure retarded osmosis and a biometric water membrane containing functional aquaporin channels.
US08123945B2 Method for making high flux, high salt rejection cellulose desalting membranes
A method is provided for producing a high flux, high salt rejection cellulose acetate desalination membrane. In this method, cellulose acetate polymer is dissolved in a first solvent such as methylene chloride or 2-methyltetrahydrofuran to produce a solution. Further steps involve stirring the solution, and thereafter permitting the solution to settle, for a time sufficient for a majority of the cellulose acetate to precipitate out of the solution to form a cellulose acetate precipitate. Next, the cellulose acetate precipitate is stirred into an excess methanol. Thereafter, the cellulose acetate is filtered out and used in making the desalination membrane.
US08123944B2 Processes of aqueous solids treatment
In the field of water treatment, this invention relates to economical methods, processes and apparatus for preparing Class A bio-solids wherein: dewatering costs and energy costs are efficient, the solids product has reduced ammonia and sulfide odor, and the concentration of solids in the aqueous solids may vary from approximately 3 to approximately 90 percent.This invention presents mesMophilic and thermophilic digestion in concert, wherein mesophilic digestion incorporates strains of Thiobacillus with nitrifiers to remove sulfide(s) and ammonia from bio-solids. Chemical dewatering of thermophilic digested bio-solids is accomplished incorporating a cationic, quatemized or an anionic polyacrylamide with at least one selected from a list consisting of: an aluminum salt, an iron salt, an amine comprising a quatemized nitrogen moiety and any combination therein. A quatemized polyacrylamide is presented alone. The use of magnesium oxide and/or magnesium hydroxide as a disinfectant/preservative for said bio-solids Is also presented.
US08123941B2 Sand filter and method of constructing same
A sand filter apparatus (10) for treating water includes a filter retention vessel (16) having an outlet (18) from which filtrate can be supplied. An inlet arrangement (48) is in fluid communication with the filter retention vessel and is connectable to a supply of waste water. A filter is interposed between the inlet arrangement and the outlet. The filter includes two layers of aggregate (12, 36) and a layer of sand (26) interposed between the two layers of aggregate. The sand is at least one of, or a mixture of, granite-based sand and substantially pure silica based sand.
US08123934B2 System and method for pretreatment of solid carbonaceous material
This invention encompasses systems and methods for pretreating a carbonaceous material, comprising heating to a suitable temperature and for a suitable reaction time, a mixture comprising the carbonaceous material, one or more catalysts or catalyst precursors, and a hydrocarbonaceous liquid.
US08123933B2 Process for using iron oxide and alumina catalyst for slurry hydrocracking
A process and apparatus is disclosed for converting heavy hydrocarbon feed into lighter hydrocarbon products. The heavy hydrocarbon feed is slurried with a catalyst comprising iron oxide and alumina to form a heavy hydrocarbon slurry and hydrocracked to produce lighter hydrocarbons. The iron oxide and alumina catalyst does not require as much iron content relative to non-gaseous material in the reactor to obtain useable products.
US08123930B2 Additives for crude oils
The invention thus provides crude oils and products which have been produced therefrom and comprise distillation residues, comprising at least one alkylphenol-aldehyde resin having a repeat structural unit of the formula where R1 is a branched alkyl or alkenyl radical which has from 10 to 40 carbon atoms and bears at least one carboxyl, carboxylate and/or ester group, R2 is hydrogen or R1 R3 is hydrogen or an alkoxy group of the formula -(A-O)m—H, A is a C2- to C4-alkylene group, m is from 1 to 100, R4 is hydrogen, a C1- to C11-alkyl radical or a carboxyl group, R5 is C1-C200-alkyl or -alkenyl, O—R6 or O—C(O)—R6, R6 is C1-C200-alkyl or -alkenyl, n is from 1 to 100 and k is 1 or 2, the use of the alkylphenol-aldehyde resin for splitting emulsions of water and crude oils or products derived therefrom, the use of the alkylphenol-aldehyde resin for improving the cold flowability of crude oils and products derived therefrom, and the use of the alkylphenol-aldehyde resin as an asphaltene dispersant in crude oils and products derived therefrom.
US08123928B2 Shut-down and start-up procedures of an electrolytic cell
A process for shutting down an operating electrolytic cell for the production of aluminium is described. The process includes: lowering anodes until a lower portion of the anodes is immersed in an aluminium layer; allowing the aluminium layer and an electrolyte bath to cool down with the lower portion of the anodes immersed in the aluminium layer; determining if the electrolyte bath is solidified, and if the electrolyte bath is solidified, raising the anodes before solidification of the aluminium layer to create a space between the solidified electrolyte bath and the anodes and the aluminium layer.
US08123925B2 Electrophoretic apparatus
An electrophoretic apparatus that allows bubbles to be readily removed out of an electrophoretic passage. The passage for electrophoretic medium, at a connecting section where capillaries filled with electrophoretic medium are connected with a pumping mechanism for filling the electrophoretic medium, is arranged such that the side of the pumping mechanism is disposed below the side of the capillaries, so that the electrophoretic medium flows from down to up at the connecting section when filling the electrophoretic medium into the capillaries. Preferably, the passage between the capillary array and the buffer solution is controlled by using a rotary-type valve having high withstand pressure to simplify the passage structure. The dead volume of the passage can be reduced and the valuable electrophoretic medium can be efficiently used. The amount of used electrophoretic medium required for the removal of the bubble can be also reduced.
US08123918B2 Method and a system for operating a physical vapor deposition process
A method for fabricating semiconductor wafers using physical vapor deposition. The method includes maintaining a substrate on a susceptor in a chamber. The substrate has a face positioned within a vicinity of a target material, which is within the chamber. The target member comprises a first side and a second side. Preferably, the first side is positioned toward the face of the substrate. The method includes operating a magnet device fixed about a rotating member, which is coupled to the chamber and is coupled to a drive motor, which is coupled to a driver. A magnet device is positioned from a center region of the rotating member by a predetermined dimension. The method includes moving the magnet device in an annular manner about the center region using the rotating member. The magnet device is rotated at a velocity v and influences a spatial region, which is positioned overlying the second side of the target. The method also includes capturing information associated with an electromagnetic energy field associated with the moving magnet device at the velocity v. The method includes processing at least a portion of the information to determine if the electromagnetic energy field is within one or more predetermined parameters. The method transfers one or more signals to the driver to adjust the velocity of the moving magnetic device to cause a change to the electromagnetic energy field.
US08123915B2 Alkaline electrolyzer
An Alkaline Electrolyzer Cell Configuration (AECC) has a hydrogen half cell; an oxygen half cell; a GSM (Gas Separation Membrane); two inner hydrogen half cell spacer screens; an outer hydrogen half cell spacer screen; a hydrogen electrode; two inner oxygen half cell spacer screens; an outer oxygen half cell spacer screen; and an oxygen electrode. The hydrogen half cell includes the hydrogen electrode which is located between said two inner hydrogen half cell spacer screens and said outer hydrogen half cell spacer screen. The oxygen half cell includes the oxygen electrode which is located between said two inner oxygen half cell spacer screens and said outer oxygen half cell spacer screen. The GSM is provided between said two inner hydrogen half cell spacer screens of the hydrogen half cell and said two inner oxygen half cell spacer screens of the oxygen half cell to from the electrolyzer.
US08123913B2 Process for separating diisopropylbenzene (DIPB) and triisoproplybenzene (TIPB) from a feed comprising DIPB, TIBP, and polyalkylate heavies
Processes and apparatuses for separating diisopropylbenzene (DIPB) and triisopropylbenzene (TIPB) from a feed including DIPB, TIPB, and polyalkylate heavies are disclosed. The disclosed processes include introducing the feed into a distillation column having a column top pressure of less than 5 psia, a column bottoms pressure of less than 3 psi, and preferably 2 psi or less above the column top pressure with a bottoms temperature ranging from about 435° F. to about 465° F. The processes also include taking off a side draw including at least 99.8 wt % of the DIPB and at least 50 wt % of the TIPB present in the feed and a bottoms stream including at least 95 wt % of the heavies contained in the distillation feed. The low temperature bottoms temperature enables high pressure steam to be used as the bottoms reboiler heat source.
US08123911B2 Press felt and method for its production
The invention relates to a felt belt, especially a press felt for a paper—, cardboard or tissue machine, with a basic structure that is formed by (a) a longitudinal reinforcement module extending on the width and length of the felt belt, including (1) a laid longitudinal thread structure on the width and the length of the felt belt which is formed by at least one longitudinal thread extending essentially in longitudinal direction of the belt, and (2) one carrying layer which is bonded with the laid longitudinal thread structure and extends on the width and the length of the felt belt, as well as (b) one cross reinforcement module which has the same length and width as the felt belt which is located on and bonded with the longitudinal reinforcement module which is formed by a plurality of cross reinforcement module segments, each of which extend on the width of the felt belt, and only on part of the length of the felt belt and which are arranged in tandem in longitudinal direction of the felt belt and which together complete the length of the felt belt, whereby each cross reinforcement segment includes a group of first threads and a group of second threads, whereby the first and the second threads cross each other at thread crossing points and together form a textile surface structure.
US08123910B2 Forming fabrics
A papermaker's fabric for use as a forming fabric. The fabric may include bondable or meltable monofilament yarns which may be formed from materials that retain substantial strength and tenacity after thermal treatment. Further, the remaining yarns in the forming fabric may be formed from materials that have a higher melting temperature than the monofilament material that will be thermally bonded or melted.
US08123902B2 Gas flow diffuser
A method and apparatus for providing flow into a processing chamber are provided. In one embodiment, a vacuum processing chamber is provided that includes a chamber body having an interior volume, a substrate support disposed in the interior volume and a gas distribution assembly having an asymmetrical distribution of gas injection ports. In another embodiment, a method for vacuum processing a substrate is provided that includes disposing a substrate on a substrate support within in a processing chamber, flowing process gas into laterally into a space defined above a gas distribution plate positioned in the processing chamber over the substrate, and processing the substrate in the presence of the processing gas.
US08123898B2 Methods of bonding optical structures, bonding and silylation of optical structures, bonded optical structures, and silylated bonded optical structures
Methods of bonding optical structures, bonded optical structures, silylated bonded optical structures, and the like, are disclosed.
US08123897B2 Room temperature fast-curing organopolysiloxane composition and its curing method
A room temperature fast-curing organopolysiloxane composition which has excellent fast curability as well as deep curability is provided without using an organic compound having C═O group and the organic compound having NH2 group which are the volatile components. A method for curing such composition is also provided. The room temperature fast-curing organopolysiloxane composition comprises: (A) 100 parts by weight of a diorganopolysiloxane having both ends terminated with hydroxy group and/or a hydrolyzable group; (B) 0.5 to 10 parts by weight of a silane and/or a siloxane having at least 3 alkenoxysilyl groups in its molecule and being capable of forming a compound having —NH2 group by hydrolysis; (C) 0.5 to 10 parts by weight of a silane and/or a siloxane having at least 3 aminosilyl groups in its molecule and being capable of forming a compound having —NH2 group by hydrolysis; and (D) 0.01 to 10 parts by weight of a curing catalyst.
US08123894B2 3-dimensional curved substrate lamination
A method of laminating a surface of a flexible material to a surface of a rigid, curved material. The method includes pressing an area of the surface of the flexible material into the surface of the rigid, curved material with a holder to create a contact area while the flexible material is conformed to the holder, which has a curvature greater than a curvature of the rigid, curved material surface; and changing the contact area between the surface of the flexible material and the surface of the rigid, curved material while maintaining pressure on the contact area until the surface of the flexible material and the surface of the rigid curved material are laminated.
US08123890B2 Process for preparing an elastic nonwoven web
A process of preparing an elastic thermally bonded nonwoven web, whereby the process is characterized by the following steps: (i) providing a thermally bonded nonwoven precursor web containing thermoplastic fibers, (ii) subjecting the precursor web of step (i) to a drawing treatment in a machine direction at a drawing rate of from 45 to 70%, and a strain rate within a range of from 1000 to 2400%/min at a temperature between the softening point and the melting point of the fibers for preparing the elastic thermally bonded nonwoven web.
US08123884B2 Implantable prosthesis having reinforced attachment sites
The present invention provides an implantable graft that includes an elongate graft tube having opposing ends defining an attachment site for attaching the graft to a stent. The graft further includes a reinforcement member attached adjacent to at least one of the ends of the graft for establishing a reinforced attachment site for the graft, thereby preventing elongation of a suture hole in the material. Furthermore, the present invention provides a graft wherein at least one end of the graft is folded over itself and glued or sutured to itself and/or the stent, thereby forming a reinforcement thereto.
US08123881B2 Die-to-robot alignment for die-to-substrate bonding
A method, a system and a computer readable medium having a set of instructions stored thereon for die-to-robot alignment for die-to-substrate bonding are described. First, a robot is aligned with a substrate to provide a pre-aligned robot. Next, a die is aligned with the pre-aligned robot to provide a robot-aligned die. Finally, the robot-aligned die is bonded to a region of the substrate. The substrate is held stationary immediately following the aligning of the robot with the substrate and at least until the robot-aligned die is bonded to the region of the substrate.
US08123876B2 Method for bonding components of medical devices
A method of bonding a first component of a medical device to a second component of the medical device, where at least one of the components comprises a shape memory material, includes positioning the components in close proximity to each other to obtain an assembled configuration, and heating the assembled configuration at a temperature in the range of from about 800° C. to about 1100° C. to obtain a diffusion bond at a region of contact between the two components. The assembled configuration is formed into a desired set shape and heat-set at a temperature in the range of from about 350° C. to about 550° C. to impart a memory of the desired set shape to the shape memory materials without substantially impairing the diffusion bond.
US08123874B2 Soft magnetic material, dust core, method for manufacturing soft magnetic material, and method for manufacturing dust core
A soft magnetic material, a dust core, a method for manufacturing the soft magnetic material, and a method for manufacturing the dust core that can improve DC bias characteristics are provided.A soft magnetic material includes a plurality of metal magnetic particles 10 whose coefficient of variation Cv (σ/μ), which is a ratio of a standard deviation (σ) of a particle size of the metal magnetic particles 10 to an average particle size (μ) thereof, is 0.40 or less and whose circularity Sf is 0.80 or more and 1 or less. The metal magnetic particles 10 preferably have an average particle size of 1 μm or more and 70 μm or less. The soft magnetic material preferably further includes an insulating coated film that surrounds a surface of each of the metal magnetic particles 10.
US08123873B2 Method for manufacturing carburized part, and steel part
A method for manufacturing a carburized part that includes vacuum carburizing a steel under a reduced pressure of 2 kPa or less, so that a surface carbon concentration after slow cooling performed after carburizing falls in a range of 0.9 to 1.5%, performing the slow cooling by air cooling at such a cooling rate that causes pearlite transformation, to transform a surface structure into pearlite; and thereafter, performing induction hardening under such heating and cooling conditions that produce fine carbides in a range of up to 0.1 mm from a surface by finely dividing cementite in the pearlite structure, where the fine carbides contain 90% or more of carbides of 1 μm or less.
US08123869B2 Dishwasher having sorption drying device
A dishwasher comprising a washing container, devices for washing dishes by means of rinsing liquor, and a sorption drying device which is connected in an air-conducting manner to the washing container via an outlet of the washing container and an inlet of the washing container. The sorption drying device is provided with a sorption column encompassing reversibly dehydratable material. The outlet and the inlet of the washing container are connected to the sorption drying device without mounting an air duct therebetween.
US08123868B2 Method and apparatus for in-line processing and immediately sequential or simultaneous processing of flat and flexible substrates through viscous shear in thin cross section gaps for the manufacture of micro-electronic circuits or displays
A method and apparatus for cleaning, drying, coating, baking etching and deposition of surfaces on glass substrate as it transitions thru and between small gaps between hydro-static porous media bearings. Due to the non-contact nature of the device extremely high pressures can be induced upon the work piece through various fluids without damage to the substrate, allowing the system to utilize the viscous nature of fluids to accomplish the desired cleaning, drying, coating, etching or baking. The process also allows for simultaneous and immediately sequential ordering of processes.
US08123865B2 Method and composition for starch extraction and modification
A method of starch extraction, starch modification, and/or malting comprising (a) steeping a starch source in the presence of an aqueous anolyte product, (b) adding an aqueous anolyte product to an intermediate product extraction slurry comprising starch and gluten, (c) adding an aqueous anolyte product to a starch product slurry produced by separating the starch and gluten, (d) contacting an extracted starch product with a type and amount of an aqueous anolyte product effective for modifying the starch product and/or (e) steeping the starch source in the presence of an aqueous catholyte product.
US08123864B2 Method and apparatus for conversion of cellulosic material to ethanol
The present invention provides an apparatus and a method for conversion of cellulosic material, such as chopped straw and corn stover, and household waste, to ethanol and other products. The cellulosic material is subjected to continuous hydrothermal pre-treatment without addition of chemicals, and a liquid and a fiber fraction are produced. The fiber fraction is subjected to enzymatic liquefaction and saccharification. The method of the present invention comprises: performing the hydrothermal pre-treatment by subjecting the cellulosic material to at least one soaking operation, and conveying the cellulosic material through at least one pressurized reactor, and subjecting the cellulosic material to at least one pressing operation, creating a fiber fraction and a liquid fraction; selecting the temperature and residence time for the hydrothermal pretreatment, so that the fibrous structure of the feedstock is maintained and at least 80% of the lignin is maintained in the fiber fraction.
US08123862B2 Deposition apparatus and manufacturing apparatus
An object of the present invention is to carry out stable film deposition for a long stretch of time without an evaporation material being stuck in a manufacturing apparatus that carries out evaporation. A driving portion that can move a crucible up and down is provided for an evaporation source of an evaporation apparatus. When the opening of the crucible is clogged with the evaporation material, the crucible is moved down and sealed in the evaporation source. The heater of the evaporation source can heat the opening efficiently; therefore, the evaporation material with which the opening is filled is evaporated; therefore, the blockage can be dissolved. Thereafter, the crucible is moved above and heated to carry out evaporation. It is possible to carry out film deposition without exposure to the atmosphere for a long stretch of time, which can improve the productivity of an organic EL element.
US08123854B2 Method of treating marine sediments and use of the resulting solid product in mortars or concretes
A method of treating marine or river dredging sediments, especially harbour zone sediments, whose free water content is between 40% and 80% by weight, for the purpose of obtaining a solid material which is easy to handle, includes the following successive steps: mixing the sediments with a treatment composition including a sulphoaluminate binder and at least one other component selected from a sulphate source and a catalyst of the hydration reactions of the sulphoaluminate binder; a step of setting of the mixture, leading to a compact mixture having a free water content of less than 20% by weight; then fractionating the compact mixture. The sediment thus treated may be incorporated into concrete or mortar formulas, which then have leachable fractions of less than 1% by weight.
US08123852B2 Cement compositions comprising high aspect ratio materials and methods of use in subterranean formations
The present invention relates to subterranean well cementing operations, and more particularly, to cement compositions that include high aspect ratio materials, and methods for using such cement compositions in subterranean formations. An example of a method of the present invention is a method of cementing in a subterranean formation. An example of a composition of the present invention is a cement composition for use in a subterranean formation.
US08123851B2 Method of finishing organic pigments
A method of finishing an organic pigment by dry-comminuting said pigment in the presence of a sulfonato-functional condensation product of an arylsulfonic acid and at least one aliphatic aldehyde having 1 to 6 C atoms as crystallization modifier, dispersing the resulting mixture of pigment and crystallization modifier in mineral acid, and swelling the pigment in the presence of the crystallization modifier in mineral acid.
US08123848B2 Fluorescent ink compositions and fluorescent particles
A fluorescent solid ink, and a method for making such ink, including an ink vehicle and a fluorescent particle. The fluorescent particle includes a fluorescent pigment, such as a trans-dicarboxylic-indenofluorenone, and at least one stabilizing wax chemically attached to the fluorescent pigment. The stabilizing wax includes an amine group at its terminal end and the fluorescent pigment includes at least one carboxylic acid group, where the amine group reacts with the carboxylic acid group to form an amide bond.
US08123847B2 Water base ink for ink-jet recording, ink cartridge, and ink-jet recording apparatus
The water base ink for ink jet recording of the present invention is a water base ink for ink-jet recording containing a coloring agent, water, a penetrant, and a surfactant; wherein the penetrant includes diethylene glycol n-hexyl ether (A); the surfactant includes at least one surfactant (B) selected from the group consisting of alkyl sulfonate, alkylbenzene sulfonate, alkyl carboxylate, and polyoxyethylene alkyl ether sulfate; a weight ratio (B/A) of (B) with respect to (A) is not less than 0.10; and the (A) is contained in the ink in an amount of 1.0% by weight to 2.5% by weight.
US08123846B2 Ink jet ink, ink jet recording method, ink cartridge, recording unit and ink jet recording apparatus
An ink jet ink providing an image having excellent lightfastness and having sticking resistance and intermittent ejection stability. The ink jet ink is characterized by containing at least a compound represented by the following general formula (I) and a compound represented by the following general formula (II).
US08123844B2 Plugging resistant mist eliminator for horizontal gas flow built from tubular elements and vane type lamella
The invention is directed at a mist eliminator for horizontal gas flow applications which is built as a combination of tubular and vane type elements and which is used to separate droplets from flue gas flows in a flue gas desulphurization (FGD).
US08123839B2 Porous polytetrafluoroethylene membrane and method of producing the same, and filter medium
First, a mixture of a polytetrafluoroethylene fine powder and a liquid lubricant into a sheet-form body extending in a first direction. Next, the liquid lubricant is removed from the sheet-form body. Then, the sheet-form body is stretched by a factor of 40 to 250 in the longitudinal direction at a temperature equal to or higher than a melting point of polytetrafluoroethylene, and the stretched sheet-form body is further stretched by a factor of 3 to 40 in the width direction. Thus, a highly air-permeable porous polytetrafluoroethylene membrane is obtained.
US08123834B2 High gain selective metal organic framework preconcentrators
Novel metal organic framework (MOF) molecules and methods of synthesizing them are described. MOFs are organometallic crystalline structures that have high sorption capacity due to high surface area, tailorable selectivity, an inert nature, and thermal stability at high temperatures. MOFs may be used as sorbents in preconcentrators for analytical devices to provide orders of magnitude of improved sensitivity in analyte detection. MOFs are also useful as sorbents in new compact and portable micropreconcentrator designs such as a modified purge and trap system and a multi-valve microelectromechanical system (MEMS) to achieve high gain in analyte detection. Further, MOFs may be used as coatings for novel microstructure arrays in micropreconcentrators where the microstructures are designed to increase the surface area to volume ratio inside the micropreconcentrator while minimizing the pressure drop across the micropreconcentrator.
US08123830B2 Filter element with particle-trapping crevice
A filter element includes a flow-through element and a floor element that abut one another to form a crevice along a crevice length between the flow-through element and the floor element. The crevice traps a portion of particles that become dislodged from the flow-through element.
US08123825B2 Microreactor and production method thereof
A microreactor is configured to have a metal substrate having a microchannel portion on one surface thereof, a heater provided on the other surface of the metal substrate via an insulating film, a catalyst supported on the microchannel portion, and a cover member having a feed material inlet and a gas outlet and joined to the metal substrate so as to cover the microchannel portion. Since the microreactor uses the metal substrate having a high thermal conductivity and a small heat capacity, the efficiency of heat conduction from the heater to the supported catalyst becomes high, and the processing of the metal substrate is easy to facilitate the production.
US08123823B2 High solids content dispersions
The present invention provides a dispersion composition containing (a) a metal base selected from the group consisting of: (i) a metal hydroxide with a solids content of greater than about 51 wt % of the composition; (ii) a metal base other than a metal hydroxide with a solids content of greater than about 15 wt % of the composition; and (iii) mixtures thereof; (b) a surfactant; and (c) an organic medium containing less than about 2 wt % of water. The invention further provides a process for preparing the composition and a method for its use.
US08123822B2 Production of biodiesel fuels which are low in glycerin and sulfur
The present invention relates to a process and apparatus for the production of carboxylic acid esters and/or biodiesel fuel from feedstocks containing fatty acids, glycerated fatty acids, and glycerin by reactive distillation. Specifically, in one embodiment, the present invention relates to the production of biodiesel fuels having low glycerin, water, and sulfur content on an industrial scale.
US08123819B2 System and method for dry cleaning articles
Systems and methods for dry cleaning articles using siloxane solvents are provided. In the systems and methods according to the present invention, the siloxane solvent suspends impurities extracted from the articles being cleaned, and the system filters off the impurities, thereby cleaning the articles.
US08123809B2 Deployment system and method for an expandable vertebral implant
Embodiments of the invention include expandable implants incorporated into a system for deploying the expandable implants to replace skeletal structures such as one or more vertebrae or portions of the spine or vertebrae. Some embodiments include related methods of implanting devices using deployment systems.
US08123807B2 Systems and methods for posterior dynamic stabilization of the spine
Devices, systems and methods for dynamically stabilizing the spine are provided. The devices include an expandable spacer or member having an unexpanded configuration and an expanded configuration, wherein the expandable member in an expanded configuration has a size, volume and/or shape configured for positioning between the spinous processes of adjacent vertebrae in order to distract the vertebrae relative to each other. The systems include one or more expandable members and a mechanical actuation means for expanding the expandable member or an expansion medium for injection within or for filling the interior of the expandable member via the port. The methods involve the implantation of one or more devices or expandable spacers.
US08123803B2 System and device for correcting hyperopia and presbyopia
The present invention includes an ophthalmic device and system of mounting for correcting hyperopia and presbyopia. The present invention includes a limbus ring mountable in an encircling relation to a central optic zone of a cornea on a limbus annulus surrounding the cornea. In the limbus ring defines a substantially annular toroid defining a first average diameter that is selectable and has a hydrophilic coating disposed thereon. The inner radius of the limbus ring is selectable such that, upon mounting on the limbus annulus, the limbus ring causes the limbus annulus to contract thereby causing the curvature of the cornea and the eye length to increase. The mounting system of the present invention is adapted to receive a limbus ring and further adapted to selectively place the limbus ring on a limbus annulus.
US08123802B2 Saddle-shaped mitral valve annuloplasty prostheses with asymmetry, and related methods
A mitral valve annuloplasty prosthesis (ring or C) has a generally saddle shape, i.e., portions of the prosthesis that are or will be adjacent the anterior and posterior commissures of the valve are relatively low as compared to at least some other portions of the prosthesis that are or will be between the commissures. However, the saddle shape is asymmetrical, in that the portion that is or will be adjacent the posterior commissure is lower than the portion that is or will be adjacent the anterior commissure.
US08123795B1 System for attaching an abdominal aortic stent or the like
A surgical tool useful for connecting an abdominal aortic stent or the like to tissue may include a head holding at least one fastener, a shaft, and a joint connecting the head to the shaft, the joint allowing the head to rotate in at least one direction relative to the shaft. That surgical tool may be used to connect a graft assembly to tissue, where the graft assembly may include a graft connected to a stent. The graft, stent and surgical tool may be inserted into a body lumen; and the head of the surgical tool may be pivoted relative to the shaft such that the distal end of the head contacts the interior of the stent. At least one fastener is then deployed to connect the stent to the body lumen.
US08123794B2 Intraluminal support frame
Intraluminal support frames for placement within a body vessel are provided. The support frames include a plurality of ring structures and first and second sets of connector segments. Connector segments of the first set join adjacent pairs of ring structures while connector segments of the second set join at least three ring structures. Medical devices are also provided that include a support frame and an additional component, such as a graft member or valve member.
US08123792B2 Perioperative warming device
A perioperative warming device includes a clinical garment having an inside surface supporting a convective apparatus with stacked sections. One section of the convective apparatus is adapted to provide comfort warming by convection. Another section of the convective apparatus is adapted to provide therapeutic warming by convection.
US08123790B2 Clinical garment for comfort warming and prewarming
A clinical garment having a lower hem and sleeves includes permeable surfaces inside near peripheral portions, a duct in communication with the permeable surfaces, and at least one inlet port opening into the duct. When worn by a patient, the permeable surfaces are positioned adjacent the patient's limbs. Warmed pressurized air may be introduced into the duct and conducted to the permeable surfaces. The warmed pressurized air circulates through the permeable surfaces to warm the adjacent limbs.
US08123787B2 Method of treating scoliosis using a biological implant
The present invention is a bone growth stimulating and promoting cytokine type biological implant preferably comprising PTH coated with a controlled release biodegradable coating that is implanted preferably in the concave side of a scoliotically curved spine in combination with a bone growth inhibiting type biological implant preferably comprising methotrexate or like anti-metabolite coated with a controlled release biodegradable coating that is implanted preferably in the convex side of a scoliotically curved spine. The insertion of the biological implant is highly non-invasion, especially as compared to more conventional spine surgical methods, and the biological implant does not decrease spinal mobility or spinal range of motion.
US08123785B2 Minimally invasive spinal stabilization system
A spinal stabilization system includes an implant and instrumentation for stabilizing the spine. In one embodiment, the system includes a plate having a side rail and a channel extending adjacent the side rail. A pedicle screw assembly is positioned in the channel in releasable engagement with the side rail. The pedicle screw assembly includes a polyaxial screw seated in a lower housing having a lower locking flange. An upper housing having an upper locking flange secures the plate to the lower housing. The side rail of the plate is releasably engaged between the upper locking flange and the lower locking flange. The upper and lower housings include on-board locking mechanisms for fixing components in the screw assembly. The screw assembly and plate are inserted and oriented by remote manipulation. Minimally invasive techniques for inserting the implant are performed with the instrumentation, and cause minimal disturbance to surrounding tissue.
US08123781B2 Screen devices and methods for closing tissue separations
A medical closure screen device for a separation of first and second tissue portions is provided, which includes a mesh screen comprising tubular vertical risers, vertical strands with barbed filaments, and horizontal spacers connecting the risers and strands in a grid-like configuration. An optional perimeter member partly surrounds the screen and can comprise a perimeter tube fluidically coupled with the vertical risers to form a tubing assembly. Various input/output devices can optionally be connected to the perimeter tube ends for irrigating and/or draining the separation according to methodologies of the present invention. Separation closure, irrigation and drainage methodologies are disclosed utilizing various combinations of closure screens, tubing, sutures, fluid transfer elements and gradient force sources. The use of mechanical forces associated with barbed strands for repositionably securing separated tissues together is disclosed. The use of same for eliminating or reducing the formation of subcutaneous voids or pockets, which can potentially form hematoma and seroma effects, is also disclosed.
US08123777B2 Apparatus and methods for aspirating emboli
Apparatus and methods for aspirating emboli from a vascular filter or stent within a patient's circulatory system are provided. A filter sac of the vascular filter permits blood flow and captures emboli from the flow. The aspiration device removes emboli from within or proximal to the vascular filter or stent to reduce the risk to the ischemia during retrieval of the vascular filter and during a treatment procedure. Retrieval of the vascular filter may be accomplished using either the aspiration catheter or a separate retrieval catheter.
US08123771B2 Lancing unit, lancing member removal tool and lancing apparatus
A lancing unit (U) includes a support member (1) provided with engagement means (19A) which is inserted into a housing (4) of a lancing apparatus (A) for engagement with an engagement surface (24a) of a lancing member (2) when the lancing member (2) is mounted to a movable member (5) of the lancing apparatus. The removal of the lancing member (2) from the movable member (5) after the lancing member (2) is mounted to the movable member (5) can be easily and reliably performed by inserting the engagement means (19A) into the housing (4) and then pulling the engagement means out of the housing (4).
US08123770B2 Angioplasty cutting device and method for treating a stenotic lesion in a body vessel
An integrally formed angioplasty cutting device for balloon angioplasty of a stenotic lesion in a body vessel. The device comprises a distal collar and a proximal collar. The device further comprises at least one strut integrally formed with the distal collar and the proximal collar. At least one of the collars has a slot formed therethrough defining a C-shaped configuration. The strut is configured to be disposed at the stenotic lesion to engage the stenotic lesion for dilatation of the body vessel during angioplasty.
US08123769B2 Thrombus removal device
A thrombi removal device includes a shaft with a distal end and a proximal end and a helical coil attached at one end to the distal end of the shaft and extending in the distal direction from the shaft. The coil has a plurality of body portions with turns or winding spaced apart longitudinally and laterally to facilitate screwing the coil into the thrombus and to provide a sufficient open area into which the thrombus can be captured. The distal end of the coil is provided with a loop. The angle of the loop relative to a longitudinal axis extending through the helical coil is about the same as the angle of at least one body portion.
US08123762B2 Suturing instrument
The suturing instrument includes an elongate member having an articulating distal portion biased offset from the elongate member, and a sheath slideably disposed about the elongate member. The user positions the sheath in contact with the articulating distal portion to actuate the distal portion relative to the elongate member. The articulating distal portion is pivotally coupled to the elongate member for improved maneuverability within the body of a patient during surgical procedures.
US08123761B2 Device for removing a tick
The invention relates to a device for removing a parasite from the skin of a host, wherein the device comprises engaging means for engaging the parasite and removing the parasite from the skin of the host, and wherein the device comprises fixation means for fixing the device on the skin of the host, wherein the engaging means are adapted for movement. The device is preferably provided with administering means for the purpose of supplying a cooling medium to at least the parasite. The invention also relates to a method for removing a parasite from the skin, comprising of engaging the parasite, removing the parasite from the skin of the host, supplying a cooling medium to the parasite, fixing the device on the skin of the host and moving the engaging means for the purpose of engaging the parasite.
US08123757B2 Inserter instrument and implant clip
A method and apparatus assisting safe one-handed insertion of an implant. An implant implantation device has a frame which includes a trigger mechanism, an outer sleeve mechanically coupled to the frame, an inner shaft having a grabber for mechanically engaging an implant, the inner shaft slidably disposed within the outer sleeve, and a retaining element disposed over the inner shaft for directing the grabber toward a closed position. An implant clip has a first member, a second member pivotally coupled to the first member, a first implant holder pivotally coupled to the first member, the coupling causing the implant clip to have a closed position and an open position, and a second implant holder, the second implant holder pivotally coupled to the second member, a surface of the first implant holder and a surface of the second implant holder remaining substantially parallel to each other while the first member and the second member pivot between the closed position and the open position.
US08123756B2 High pressure delivery system
This relates to an improved delivery system for accurately loading and controlling the delivery of flowable material to a patient. Particularly, the system may be used in the injection of hard tissue implant materials such as PMMA under pressures up to about 4000 psi. The system includes an applicator with a first column having an implant material introduction section adapted to provide for effective loading of the implant material and a second column housing a piston. The introduction section has a larger size than that of a vessel section or bore in which the requisite pressure seal between the piston and bore wall is formed. The first column may include an introduction section flared open to an included larger funnel-like opening or a separate funnel may be used that interfaces with the introduction section to facilitate the introduction of implant material. Handles on the first and second columns to be turned relative to each other to advance the columns toward each other may be provided for manual actuation of the applicator to drive implant material through a cannula and deliver implant material to a desired site.
US08123755B2 Tissue distraction device
An apparatus and method is provided for interbody fusion including distracting, in a given direction, and supporting opposing vertebral bodies. A plurality of wafers are consecutively inserted between the vertebral bodies to create a column of wafers. The column of wafers is oriented between the vertebral bodies so as to expand in the given direction as the wafers are consecutively added to the column.
US08123752B2 Systems and methods for injecting bone filler into the spine
A method for strengthening a spinous process comprises positioning a framework over an outer surface of the spinous process, the framework comprising a mesh connected to a frame. Bone filler is distributed over the mesh so that the bone filler contacts the mesh and contacts the spinous process. The bone filler is allowed to cure. A jig is positioned at the spinous process so that a slot through the jig is exposed to a side of the spinous process. A cannula is oriented so that the cannula is receivable in the slot, and insertable into the spinous process through the slot. Bone filler is injected into the spinous process by way of the cannula, with the injection terminating when a desired amount of bone filler has been injected into the spinous process. The cannula is then removed and the bone filler allowed to cure within the vertebra. The above steps can also be accomplished simultaneously or in any order. Further, bone filler injected into the spinous process can also contact the mesh as the bone filler passes at least partially through the spinous process.
US08123750B2 Apparatus and methods for removal of intervertebral disc tissues
Apparatus and methods for removing tissue from an intervertebral disc are disclosed. The apparatus can include an elongated guide tube, a rotary cutting member and a drive shaft. Other apparatus can include an elongated guide tube, an inner guide tube, a cutting head, a rotary cutting member and a drive shaft. The elongated guide tube has a bendable end. The apparatus are generally configured to extend and withdraw a rotary cutting member while controllably bending the bendable end of the guide tube.
US08123749B2 Low profile spinal tethering systems
Methods and devices for treating spinal deformities are provided. In one exemplary embodiment, a low-profile spinal anchoring device is provided for receiving a spinal fixation element, such as a tether, therethrough. The device generally includes a staple body that is adapted to seat a spinal fixation element, a fastening element for fixing the staple body to bone, and a locking assembly for coupling a spinal fixation element to the staple body. In one embodiment, the locking assembly includes a washer that is adapted to couple to the staple body such that the spinal fixation is disposed therebetween, and a locking nut that is adapted to engage the staple body to mate the washer to the staple body.
US08123745B2 Ablation catheter with optically transparent, electrically conductive tip
A catheter enables real-time light measurements, for example, without limitation, diffuse reflectance, fluorescence, etc., from biological materials, such as tissue (including blood), while performing RF ablation. The catheter tip design isolates illumination and collection paths such that light exits the catheter tip and travels through the tissue of interest (e.g., cardiac tissue or blood) before returning to the catheter tip. Such a design advantageously avoids saturation of the optical detector, and ensures diffusion of the illumination light within the medium of interest. The catheter has a catheter body and a tip electrode. The tip electrode has an exterior shell, an inner layer of diffuse material and a hollow cavity, wherein the inner layer is configured to transmit light outside the tip electrode to a tissue via a set of illumination openings in the shell wall and the hollow cavity is configured to receive light from the tissue via a set of collection openings in the shell wall and the inner layer. An inner surface of the inner layer has a reflective coating to isolate light injected into the inner layer from light collected in the hollow cavity. There are a first optical waveguide extending between the catheter body and the tip electrode to inject light into the inner layer and illuminate the tissue, and a second optical waveguide extending between the catheter body and the tip electrode to collect the recaptured light in the hollow cavity.
US08123742B2 Catheter and method for ablation of atrial tissue
Featured is a catheter device for ablating tissue that includes an elongated body member having a distal portion and a deflection mechanism operably coupled to the distal portion so as to cause the distal portion to deflect with respect to a longitudinal axis of the elongated body member. Such a catheter device also includes a guide member and a guiding mechanism that is coupled to the elongated body member and is configured so as to guide the guide member. The guiding mechanism includes an exit portion from which the guide member exits during deployment. The exit portion is disposed with respect to the distal portion end so the distal portion deflects from and with respect to the guide member as well as rotating about the guide member. Also featured are systems and methods related thereto.
US08123739B2 Drainage catheter and method for catheterizing a patient
In at least one embodiment of the present invention, a drainage catheter for draining part of patient's body is provided. The catheter comprises an elongated member having a proximal portion extending to a distal portion and a lumen formed therethrough for fluid communication with the patient's body. The distal portion is formed of a polymer material having a first phase transition temperature and a second phase transition temperature that is less than the first phase transition temperature but is greater than about body temperature. The distal portion has a first configuration when at about body temperature for at least one of moving and anchoring the distal portion within the patient's body. The distal portion self-configures to a second configuration when at a temperature of at least the second phase transition temperature for retrieval of the distal portion from the patient's body.
US08123737B2 Multichannel catheter
This invention is a single, multichannel catheter useful for extracorporeal circulation of blood to a patient undergoing cardiovascular treatments or surgery. The catheter has three independent channels and an expandable balloon at one end of the catheter. The first channel (34) is the largest and is of a size that allows for delivery of blood to a patient in an amount sufficient to maintain the patient's metabolism and perfusion throughout the treatment or surgery. A second channel (36), smaller than the first, is integrated into the wall of the first channel, and is suitable for delivering a biologically active fluid (e.g., for cardioplegia) to the heart and/or venting the left heart. A third channel (38), also smaller than the first, is integrated into the wall of the first channel, and suitable for delivering a fluid to the balloon for its expansion when positioned in the ascending aorta to occlude the flow of blood to the heart. It is important that the first channel accounts for at least about 70% of the total channel volume. The catheter provides an improved means of performing cardiovascular surgery on a patient using a cardiopulmonary machine for extracorporeal circulation of blood. The catheter is particularly useful for cardiac surgery. The multichannel catheter is best prepared using an extrusion molding technique.
US08123732B2 Bowel management system
A bowel management system includes a waste collection catheter having at least two distinct sections. The first section is patient proximal when disposed in the patient's rectum and has durometer hardness in the range of about 50 A to about 90 A. The second catheter section is connected to the first section and has durometer hardness in the range of about 5 A to about 49 A. A selectively collapsible, substantially spherical retention balloon is attached coaxially and exterior of the first catheter section such that the proximal-most end of the retention balloon is coincident to the proximal-most end of the first section of the waste collection catheter, the substantially spherical retention balloon having an inflated size so as to be sufficiently large enough to retain the patient proximal end of the catheter in the patient's rectum without being so large as to trigger a defecatory response in the patient.
US08123731B2 Method and apparatus for disposing of liquid surgical waste for protection of healthcare workers
An improved method for measuring and automatically disposing of infectious waste generated during and after surgical and clinical procedures is provided. The infectious waste removal device includes a suction source, a method for pressure verification, separation chamber for isolating fluids, containment reservoir, measurement chamber for determining fluid received, an information source for such fluid volumes, a quantitative method for calculating fluid dynamics, a post use cleaning method, and other attributes for use by the surgical team or healthcare staff in order to minimize health care worker handling of said infectious waste and to limit their possible exposure.
US08123730B2 Medicinal composition and wound contact layer with a composition
The invention relates to a wound dressing, a wound contact layer and a medicinal composition comprising a hydrophilic base in which hydrocolloids are dispersed, wherein the hydrophilic base comprises at least one emulsifier and the use of said composition is for the treatment of wounds.
US08123725B2 Portable infusion pump of the skin patch type with spiral collapsible reservoir
An ambulatory pump comprising a reservoir (1) for holding the fluid to be pumped and having an outlet (7) through which fluid is expelled in use; a closure (8) device movable relative to the reservoir; and an actuator (14) for moving the closure device relative to the reservoir, wherein the reservoir is arranged in a spiral pattern.
US08123722B2 Devices, systems and methods for treating disorders of the ear, nose and throat
Sinusitis, mucocysts, tumors, infections, hearing disorders, choanal atresia, fractures and other disorders of the paranasal sinuses, Eustachian tubes, Lachrymal ducts and other ear, nose, throat and mouth structures are diagnosed and/or treated using minimally invasive approaches and, in many cases, flexible catheters as opposed to instruments having rigid shafts. Various diagnostic procedures and devices are used to perform imaging studies, mucus flow studies, air/gas flow studies, anatomic dimension studies and endoscopic studies. Access and occluding devices may be used to facilitate insertion of working devices such asendoscopes, wires, probes, needles, catheters, balloon catheters, dilation catheters, dilators, balloons, tissue cutting or remodeling devices, suction or irrigation devices, imaging devices, sizing devices, biopsy devices, image-guided devices containing sensors or transmitters, electrosurgical devices, energy emitting devices, devices for injecting diagnostic or therapeutic agents, devices for implanting devices such as stents, substance eluting or delivering devices and implants, etc.
US08123721B2 Catheter having independently-deflectable segments and method of its manufacture
A catheter shaft includes a wall defining a lumen, a distal segment, and a proximal segment. At least one distal segment deflection wire extends through the proximal segment and terminates in the wall in the distal segment, while at least one proximal segment deflection wire extends through the proximal segment and terminates in the wall in the proximal segment. The proximal and distal segment deflection wires respectively permit the proximal and distal segments of the catheter shaft to deflect independently of each other. The catheter shaft may also include one or more wire reinforcing layers embedded in the wall.
US08123717B2 Therapy delivery system having an open architecture and a method thereof
A therapy delivery system having an open architecture and method of providing thereof are disclosed. The present invention provides a therapy dosage module having a control algorithm that can be replaced with a predefined or independently defined control algorithm. The tools necessary to create and test such control algorithms in the therapy dosage module in a simulated environment before implementing it in a live therapy system are also disclosed.
US08123713B2 System and method for collecting plasma protein fractions from separated blood components
Method and apparatus for separating plasma from blood in a separation vessel and further separator the separated plasma into desired plasma proteins in a plasma separator fluidly connected to the separation vessel to receive the separated plasma.
US08123710B2 Limiting connector for knee brace
A limiting connector for a knee brace has a first arm, a second arm and an angle adjusting assembly. The second arm is connected pivotally to the first arm. The angle adjusting assembly is mounted between the first arm and the second arm, and has a positioning gear, a gear cap, two buttons and a rotating cap. The gear cap is mounted through the positioning gear and the second arm, and is mounted on the first arm to hold the positioning gear between the second arm and the gear cap. The buttons are selectively slid to engage the positioning gear and define a range of rotation between the first and second arms. The rotating cap is rotatably mounted through the gear cap, and pushes the positioning gear toward the first arm to disengage the positioning gear from the buttons for adjusting the range of rotation.
US08123707B2 Method and apparatus for connective tissue treatment
The invention relates to methods and apparatus for therapeutically treating connective tissue or increasing vascularization in tissue using ultrasound. More particularly, the present invention relates to methods and apparatus which use ultrasound to stimulate growth or healing, or to treating pathologies, of connective tissue, or to increase vascularization in ischaemic or grafted tissue using ultrasound.
US08123705B2 Adjustable profile probe
An adjustable profile probe for insertion in a body cavity to sense a biological parameter includes an elongated shaft having a sensor panel and a resiliently expandable portion substantially opposing the sensor panel. An expansion mechanism is at least partially housed within the elongated shaft for varying the profile of the probe. The expansion mechanism includes a base plate adjacent to the resiliently expandable portion and a plurality of lever arms pivotally mounted to the base plate and the sensor panel. An actuating member pivotally connects to the lever arms such that upon movement of the actuating member, the resiliently expandable portion is selectively collapsed or expanded by the plurality of lever arms pivoting between a minimal profile position near parallel with the elongated shaft and an expanded profile position with the lever arms being near perpendicular to the elongated shaft.
US08123702B2 Composite guide wire with drawn and filled tube construction
The present invention is directed to an intracorporeal device, preferably a guidewire, and method for making the device. The guidewire of the present invention is formed, at least in part, of a composite elongate core formed, at least in part, of precipitation hardened material. The elongate core members of the present invention will have an ultimate tensile strength and modulus of elasticity greater than the same for an identically dimensioned elongate member formed from superelastic NITINOL alone.
US08123701B2 Methods and apparatus for sampling and analyzing body fluid
A sampling device for sampling body fluid includes a lancet for making an incision, a capillary tube for drawing-up body fluid from the incision, and a test strip affixed to an upper end of the capillary tube for receiving the fluid. An absorbent pad can be disposed between the test strip and capillary tube for spreading-out the fluid being transferred to the test strip. An onsite analyzer such as an optical analyzer and/or an electrochemical analyzer can be mounted in the device for analyzing the fluid. Alternatively, a test strip can be slid through a slot formed in the bottom end of the device so that by passing the device against the skin after an incision has been formed, the test strip will directly contact body fluid emanating from the incision.
US08123700B2 Method and apparatus for lancet launching device integrated onto a blood-sampling cartridge
A method and apparatus (2) for obtaining a sample of blood. An embodiment includes an apparatus (2) which integrates lancing (12), sample collection, and analysis. The presence of patients finger on the active sampling area can be sensed by monitoring the pressure applied by the finger on the device (2).
US08123694B2 Electro pneumatic interface for blood pressure system
A blood pressure system that includes a compact monitor housing that contains a pneumatic circuit and an electrical circuit and a processor for inflating and deflating a cuff to provide blood pressure related data. A split connector allows the housing to interface both pneumatically and electronically with one or more independent cuffs and/or with one or more host stations. Each host station contains a dependent cuff and further electrical components to expand and enhance the systems output of related blood pressure data that is generated by either the independent or dependent cuffs.
US08123693B2 Methods and devices for determining lumen occlusion
Embodiments of the present invention describe methods of determining the occlusion of body lumens and apparatuses for doing so. In one particular embodiment, the occlusion of the fallopian tubes by an intrafallopian contraceptive device may be confirmed by contrast enhanced ultrasonography (also known as stimulated acoustic emission hysterosalpingo-contrast sonography). In these embodiments a contrast agent containing microbubbles is used.
US08123690B2 Ultrasound observation apparatus
An ultrasound observation apparatus of the present invention is an ultrasound observation apparatus capable of creating a blood flow image of a subject by receiving a reflection signal of a sound output signal transmitted to the subject as an electric signal, and performing various kinds of signal processing for the electric signal, and includes a transmission frequency switching section switching a frequency band of the sound output signal which is transmitted to the subject to a frequency band corresponding to an instruction signal which is outputted from an operation instructing section, and a blood flow color creating section changing a color at a time of visualizing the blood flow image by linking with switching of the frequency band by the transmission frequency switching section.
US08123688B2 Ultrasound diagnosis apparatus
An angle calculating unit calculates a bending angle of a bone based on a plurality of surface points. A characteristic data calculating unit determines an indication value which reflects a load applied on the bone, a bone length of the bone, and a position of a fractured part. The characteristic data calculating unit calculates, as characteristic data reflecting a mechanical characteristic of the bone, a proportionality constant indicating a ratio between the indication value and the bending angle of the bone.
US08123687B2 Intraocular pressure sensor
An implantable intraocular pressure sensor system has a sealed geometric shape with an internal pressure at a first value. The sealed geometric shape has a first light permitting surface and a second flexible surface. A pair of photocells is located in the sealed geometric shape. A light shield is coupled to the second flexible surface. When the second flexible surface is deflected, a light measurement by the pair of photocells indicates an intraocular pressure condition.
US08123686B2 Method and apparatus for providing rolling data in communication systems
Methods and systems for providing data communication in medical systems are disclosed.
US08123678B2 Endoscope apparatus, actuators, and methods therefor
The present invention provides, in part, a dexterous endoscope apparatus, referred to herein as a MicroFlex Scope (MFS). The MFS is an novel, small diameter, e.g., less about 1 mm to about 4 mm, about 1 mm to about 3 mm, etc., dexterous endoscope that allows for access, direct visualization, tissue sampling, treatment, etc. of body lumens. In one embodiment, the distal end of the MFS of the invention is an ultra-flexible tip that comprises a plurality of thin, curved shape memory alloy (SMA) actuator elements attached to at least one structural skeleton, e.g., a coil spring skeleton or hinge structure. The SMA actuator elements in each structural skeleton segment are indirectly heated by a heater element and produce force in response to their temperature relative to specific thresholds. In certain embodiments, the heater element may include an integrated heater/sensor element adapted to heat the actuator element and to sense the temperature and bend state of the actuator element. In configurations comprising a plurality of actuator elements, multiplexing/demultiplexing of heating currents and sensor voltages may be accomplished via a parallel bus and demulitplexing circuit. In this regard, a demultiplexing circuit using standard microelectronic fabrication techniques may be designed to achieve individual sensing and control over each actuator element.
US08123675B2 System and method for augmentation of endoscopic surgery
A robotic device for use in surgery includes a first surgical instrument having a proximal end, a distal end, and a shaft extending therebetween, the distal end of the first instrument and adjacent shaft being insertable distally into a first incision; a first manipulator movably supporting the first instrument; a plurality of motorized drives coupled to the manipulator; an input device having an input movable in two degrees of freedom; and a computer coupling the input device to the motorized drives so that the motorized drives effect a motion of the first surgical instrument in response to movement of the input, a center of the motion located along the shaft at the incision when the first instrument is used during surgery.
US08123667B2 Centrifuge, in particular separator, having a feed line for control fluid
A separator includes a rotatable centrifugal drum having a vertical axis of rotation. The separator includes a rotatable drive spindle to drive the drum, an hydraulic system located in an interior of the drum and at least one feed line to feed a control fluid to the drum, the at least one feed line having an outlet region. Further included is a ring non-rotatably connected to the drum, a gap located between one of the drive spindle and the drum and the drive spindle and the ring. The feed line leads out radially in front of the drive spindle in the outlet region. The outlet region is oriented and configured such that emerging control fluid is spread directly against the drive spindle, and a portion of the control fluid enters through the gap into the hydraulic system.
US08123655B2 Power output apparatus, drive system, and control method of power output apparatus
The technique of the invention is applied to a motor vehicle where an engine and a first motor are linked to a driveshaft via a planetary gear mechanism, a second motor is linked to the driveshaft via a transmission, and a battery is arranged to receive and transmit electric power from and to the first motor and the second motor. In response to a deviation of the charge-discharge state of the battery from an allowable control range set as an allowable charge state range of the battery during an upshift, gear change control of the invention sets a gearshift condition change flag F1 to 1 (step S360) and sets a value N2 having a smaller absolute value than a value N1 to a target rotation speed change ΔNm2* of the second motor (step S380). The gear change control then sets a hydraulic pressure command Pb1* of a brake B1 included in the transmission to make an actual rotation speed change ΔNm2 of the second motor approach to the target rotation speed change ΔNm2* (step S400). This arrangement reduces a rate of change in rotation speed Nm2 of the second motor. The reduced rate of change in rotation speed Nm2 prevents a continuous decrease or a continuous increase in power consumption of the second motor that is caused by, for example, delayed detection, delayed computation, and delayed communication, thus effectively protecting the battery from excessive power input and excessive power output.
US08123653B2 Continuously variable transmission
A continuously variable transmission (CVT) having a main shaft configured to support and position various components of the CVT. Shift cam discs cooperate with ball-leg assemblies to shift the transmission ration of the CVT. Load cam discs, a torsion disc, rolling elements, and a hub cap shell are configured to generate axial force, transmit torque, and manage reaction forces. In one embodiment, a splined input shaft and a torsion disc having a splined bore cooperate to input torque into the variator of the CVT. Among other things, various ball axles, axle-ball combinations, and reaction force grounding configurations are disclosed. In one embodiment, a CVT having axial force generation means at both the input and output elements is disclosed.
US08123650B2 Multi-speed transaxle for a front wheel drive vehicle
A front wheel drive transmission is provided having an input member, an output member, four planetary gear sets, a plurality of coupling members and a plurality of torque transmitting devices. Each of the planetary gear sets includes a sun gear member, a planet carrier member, and a ring gear member. The torque transmitting devices include clutches and brakes arranged within a transmission housing.
US08123646B2 Vehicle transmission with continuously variable transmission ratio
A first embodiment of a vehicle transmission with continuously variable transmission ratio contains a CVT variator with two variator shafts, an input shaft that can optionally be brought into rotational engagement with one or the other of the variator shafts, and an output shaft that can optionally be brought into rotational engagement with one or the other of the variator shafts, such that two forward driving ranges with opposite torque transmission directions of the CVT variator are present, whose transmission ratio ranges are constantly contiguous with each other.
US08123644B2 Traction-drive type driving-force transmission mechanism and image forming apparatus equipped therewith
A traction-drive type driving-force transmission mechanism has a sun roller. Planetary roller units are orbitally movable along an outer surface of the sun roller. A pressing member presses the planetary roller units toward the outer surface of the sun roller and allows a driving force to be transmitted by a traction force between the sun roller and the planetary roller units. Each planetary roller unit includes a first planetary roller rotatably supported by a first shaft and adapted to move orbitally along the outer surface of the sun roller, and a second planetary roller rotatably supported by a second shaft while allowing an outer surface thereof to contact an outer surface of the first planetary roller and the pressing surface, and adapted to press the outer peripheral surface of the first planetary roller against the outer peripheral surface of the sun roller during orbital movement of the planetary roller unit.
US08123643B2 Control device for vehicular drive system
A control device for a vehicular drive system including a differential portion having a differential mechanism operable to distribute an output of an engine to a first electric motor and a power transmitting member, and a second electric motor disposed in a power transmitting path between the power transmitting member and a drive wheel of a vehicle, the control device including a differential limiting device provided in the differential mechanism and operable to limit a differential function of the differential mechanism for thereby limiting a differential function of the differential portion, and a torque-response control portion for controlling a response of a change of an input torque of the differential portion to an operation of a manually operable vehicle accelerating member, depending upon whether the differential function of the differential mechanism is limited or not.
US08123638B2 High bounce structure: sky ball
A play ball having a high bounce capacity of at least 20 vertical feet and as much as 50 or 75 vertical feet is formed of a solid, elastomer thermoplastic polyurethane having a wall thickness of 3-5 mm, containing gas at a pressure preferably greater than 0.65 kfg/cm2.
US08123636B1 Hunting arrow with phosphorescent indicator
A device and method by which hunting arrows are provided with a plurality of phosphorescent vanes to aid in their location and retrieval, particularly during times of limited visibility is herein disclosed. The plurality of vanes of the arrow are coated with a phosphorescent paint which will self-luminescence at night and give off radiation in the form of visible light. Additionally, the phosphorescent nature of the paint makes finding the arrow easier during the day.
US08123635B2 Arm extension apparatus
An arm extension apparatus includes a base having an elongate configuration. The apparatus includes a paddle coupled to the base and having proximal and distal portions, the paddle being slidably movable relative to the base between a retracted configuration in which the proximal portion is substantially received adjacent the base and an extended configuration in which the proximal portion is substantially extended from the base. An attachment member is coupled to the base and having a configuration complementary to the person's arm, the attachment member having a strap extending therefrom for removably securing the attachment member to the person's arm.
US08123634B1 Programmable basketball shot setup and return device
An automatic or manually operated basketball return unit with remote control device that is placed under a basketball hoop having a hopper at its top distal end that funnels down to a return tube allowing basketballs to engage a motorized return mechanism which expels the basketball out a return chute and too the user. The return unit comprises a support housing with rotating compression wheels, each having a motor which ejects the ball out an aperture. The unit rotates 180 degrees manually or automatically.
US08123633B2 Multi-layer golf ball
Golf balls consisting of a dual core and a dual cover are disclosed. The dual core consists of an inner core layer formed from a rubber composition and an outer core layer formed from a highly neutralized polymer composition.
US08123632B2 Multi-layer golf ball
Golf balls consisting of a dual core and a dual cover are disclosed. The dual core consists of an inner core layer formed from a rubber composition and an outer core layer formed from a highly neutralized polymer composition.
US08123630B2 Multi-piece solid golf ball
The present invention provides a multi-piece solid golf ball having a core, an envelope layer, an intermediate layer, and a cover, in this order, and has formed on a surface thereof a plurality of dimples. The core has a hardness which gradually increases from a center to a surface thereof, the hardness difference in JIS-C hardness units between the core center and the core surface being at least 15 and, letting (I) be the average value for cross-sectional hardnesses at a position about 15 mm from the core center and at the core center and letting (II) be the cross-sectional hardness at a position about 7.5 mm from the core center, the hardness difference (I)−(II) in JIS-C units being not more than ±2. The envelope layer, intermediate layer and cover have hardnesses which satisfy the condition: cover hardness>intermediate layer hardness>envelope layer hardness.
US08123628B2 Multi-piece solid golf ball
The invention provides a multi-piece solid golf ball composed of a solid core encased by a cover of one or more layer, which solid core has an inner core layer and an outer core layer. The inner core layer is formed primarily of a thermoplastic resin, has a diameter of from 3 to 20 mm, and has a cross-sectional hardness difference of within ±5 between any two points on a cross-section obtained by cutting the inner core layer in half. The outer core layer is formed of a rubber composition made primarily of polybutadiene rubber. The solid core has a diameter of from 35 to 42 mm. The ball has specific relationships between the hardness of the inner core layer 1 mm inside a boundary between the inner core layer and the outer core layer, the hardness of the outer core layer 1 mm outside the boundary, and the surface hardness of the outer core layer. Such a golf ball is able to achieve an increased distance and has a good feel on impact.
US08123621B2 Storing data in wagering game systems
Systems, methods, and apparatus for storing wagering game data are described herein. In one embodiment, an apparatus includes a wagering game unit configured to begin presentation of a wagering game and to request that wagering game data be stored. The wagering game can also be configured to wait for an indication that the wagering game data has been stored, and, after receipt of the indication, to resume presentation of the wagering game. The apparatus can also include a non-volatile random access memory (NVRAM) configured to store the wagering game data. The apparatus can also a hard disk drive configured to store the wagering game data. The apparatus can also include a storage controller configured to direct storage of the wagering game data in the NVRAM in response to the wagering game unit's request, to provide to the wagering game unit an indication that the wagering game data has been stored, and to direct storage of the wagering game data to the hard disk drive.
US08123615B2 Multiplayer gaming machine capable of changing voice pattern
Herein disclosed is a gaming machine executing a game and paying out a predetermined amount of credits according to a game result; generating voice data based on a player's voice; identifying a voice pattern corresponding to the voice data by retrieving the dialogue voice database and identifying a type of voice corresponding to the voice data, so as to store the voice data along with the voice pattern into the memory; calculating a value indicative of a game result, and updating the play history data stored in the memory using the result of the calculation; comparing the play history data thus updated with a predetermined threshold value data; generating voice data according to the voice pattern based on the play history data if the play history data thus updated exceeds the predetermined threshold value data; and outputting voices from the speaker.
US08123614B2 Gamepiece controller using a movable position-sensing display device including a movement currency mode of movement
Embodiments of the invention provide a method and apparatus for moving a gamepiece in an electronic game where gamepieces are moved by user movement of devices. For example, cell phones may be used to control gamepiece movement on a table top or other surface. Each user moves their respective cell phone to control the movement of their gamepiece. Other user controls can be used to provide additional interaction. One embodiment discloses a tank game where each user operates a tank that is used to shoot at other user gamepieces in real time as the users move about a table top surface. Details are provided of two specific types of movement, but other types of movement are possible.
US08123613B2 Method and apparatus for integrated customer tracking and browsing
A system and method for tracking customer activity without need for an extensive interconnecting network. The system includes a plurality of gaming devices that are communicatively isolated from one another. Information, including tracked customer activity, bonus requirements, and in one embodiment, personal information, is stored on a memory device communicable with the gaming devices. This allows implementation of an incentive program at reduced cost because the service devices themselves need not be networked together.
US08123610B2 Wagering game with group free-spin bonus
A method of conducting a wagering game on a plurality of gaming machines. The method includes receiving wagers from players at the plurality of gaming machines to play a basic game. A plurality of symbols is displayed on each of the plurality of gaming machines. The plurality of symbols indicate a randomly selected outcome at each of the plurality of gaming machines. The method also includes aggregating a plurality of special-game triggering events at the plurality of gaming machines. In response to a predetermined number of the plurality of special-game triggering events being achieved, a community-based special event involving eligible of the plurality of gaming machines is initiated.
US08123604B2 Gaming system with card game and post round of play display of tracked cards
A gaming device having a primary game and a secondary game is provided. The gaming device includes a primary game, such as blackjack or 21 operable on a wager by a player, and an optional secondary game that is operable on a secondary game wager by a player. After placing a secondary game wager and satisfying certain criteria in the primary game, one or more players are provided with a secondary game card to be used in the secondary game. The secondary game is resolved after a player has accumulated a plurality of secondary game cards over the course of several sequentially played rounds of the primary game.
US08123603B2 Gaming machine allowing player to select dealer and control method thereof
A gaming machine of the present invention displays a dealer image selected from a plurality of types of dealer images to a display, and offers a profit (e.g. a game support advantageous for the player) in accordance with the dealer image to a station where an additional BET has been placed. Then, the gaming machine calculates and compares a total number of BETs in each station over a unit number of games, and accepts a selection of a dealer image at the station where the total number of BETs is the largest.
US08123602B2 Game device and program
A game device for performing a game such that, when a first-choice display object is freely chosen via a pointing operation performed by a player from among a large number of display objects, a second-choice object is then required to be determined as a correct choice. The game device includes a determining means determining whether or not the display object of interest has been chosen based on position coordinates input from an input means and a choice determination range. The game device also includes a correcting means performing, when the correct second-choice object has been determined, correction processing for changing the size of a choice determination range for a display object of interest used for the determination processing so that the choice determination range for a correct choice display object becomes relatively larger than the choice determination range for an incorrect choice display object.
US08123600B2 Storage medium storing game program and game apparatus
A game apparatus causes a character object to perform a first hitting motion on the necessary condition that a to-be-hit object is present in a first area 104a which is set based on a position of the character object in a virtual game space, and causes the character object to perform a second hitting motion on the necessary condition that the to-be-hit object is present in a second area 104b, 104c, or 104d. Furthermore, the game apparatus adjusts a position of at least one of at least a part of the character object and the to-be-hit object, such that when the character object is caused to perform the second hitting motion, the character object and the to-be-hit object are in a predetermined positional relationship.
US08123591B2 Abrasive pump for an abrasive jet cutting machine
An abrasive supply system may, for example, be used to supply abrasive particles such as garnet to a cutting nozzle of an abrasive jet cutter. According to an embodiment, the abrasive is propelled by a substantially constant flow rate gas source. According to an embodiment, the system may be supplied with abrasive from an atmospheric pressure abrasive hopper. According to an embodiment, a controller automatically actuates refilling of an abrasive tank from the abrasive hopper, and then automatically closes an abrasive supply valve and restarts abrasive propulsion. According to an embodiment, the controller may include or consist of pneumatic logic.
US08123590B2 Double-layer fabric garment and production method
Described is a double-layer fabric garment. The garment is formed of a tubular fabric element that comprises a first portion and a second portion. The first portion includes an initial edge portion. The second portion has specific areas of fabric with increased compression strength and an end portion. The initial edge of the first portion is connected with the end portion of the second portion, thereby creating a space between the first portion and the second portion and forming a seamless double-layer fabric garment. Thus, the first portion operates as an outer fabric layer and the second portion operates as an inner fabric layer, whereby the specific areas of fabric with increased compression strength of the second portion provide an increased shaping effect to a user while wearing the double-layer fabric garment. Therefore, the inner fabric layer provides a shaping effect while concealed by the overlaid outer layer.
US08123587B2 Convertible bra
An intimate apparel apparatus includes a brassiere frame with a chest band for securing the brassiere frame to the wearer, and a first arcuate recess in the brassiere frame for receiving a first detachable brassiere cup. A first arcuate channel is located along the edge of first arcuate recess. A first detachable brassiere cup has a first arcuate latch at a perimeter thereof. The first arcuate latch and the first arcuate channel are slidably engageable with one another, and have substantially identical cross sections, such that the substantially identical cross sections resist transverse separation from each other when slidably engaged. An intimate apparel set includes at least one brassiere garment as described above, and additionally further pair or pairs of detachable brassiere cups, interchangeable with those already described.
US08123582B2 Manufacturing method of airtight container and image displaying apparatus
An airtight container manufacturing method includes the steps of exhausting an inside of a container through a through-hole provided in the container, arranging a plate member having, at its periphery, grooves penetrating the plate member in its plate thickness direction, on an outer surface of the exhausted container, so as to close up the through-hole, and providing a sealant on the plate member. In addition, a cover member covers the plate member via the sealant, and the container is sealed by closing the cover member on the plate member. In the sealing step the sealant is deformed and flows from the adjacent grooves to form a continuous shape and fill a space between the cover member and the outer surface of the container and along the periphery of the plate member.
US08123580B1 Interface system for segmented surfboard
A waterboard includes a head segment having a concave rear edge, a tail segment having a convex front edge, an interface system adapted to removably connect the head and tail segments together. The interface system includes a head interface connecter having a convex first surface attached to the concave rear edge of the head segment and having a first blade element extending from a second surface thereof, and includes a tail interface connecter having a concave first surface mating attached to the convex front edge of the tail segment and having a second surface mating with and removably attached to the second surface of the first interface connecter, wherein the tail interface connecter includes a slot to receive the blade element.
US08123578B2 Device for reducing the power demand for the propulsion of a ship
A device for reducing the power demand for the propulsion of a ship, and for broad-built or non-broad-built not-very-fast ships of any type which is affixed to the hull at a short distance upstream of the propeller, comprises a fore-nozzle with fins or hydrofoils that are arranged within the fore-nozzle, wherein the fore-nozzle, at the top, can be tilted forwards by up to 8°, on a horizontal transverse axis that extends through the centre of the fore-nozzle.
US08123576B2 Connecting structure of snap electrode and electric wire
A structure of electrically connecting a snap electrode for medical purposes is easily attached/detached to/from various monitoring pads attached to a human body to measure electrocardiogram (ECG), electromyogram (EMG), brain wave and nervous system signals and electrically connected to medical equipment, to an electric wire using a pressing method instead of welding. The connecting structure of a snap electrode and an electric wire includes a body having a convex portion, which is formed on the top of the body and has a groove formed on the circumference thereof, in which a combining part is fitted, and the combining protrusion having a ring shape and including a predetermined number of elastic fixing pieces protruded from the inner side thereof and a pair of first pressing pieces protruded from one side thereof and combined with an electric wire. A combining protrusion of a pad is inserted into the body.
US08123575B2 Crimping terminal fitting, method of forming it and wire with terminal fitting
A crimping terminal fitting has a wire barrel (21) to be crimped and connected to core strands (31) of a wire (30). The wire barrel (21) has a base plate (23) continuously extending from a ground terminal (11) in a longitudinal direction. Two core crimping pieces (25) extend from the opposite sides of the base plate (23). A thinned portion (27) is formed at least at a leading end of each core crimping piece (25) and is thinner than the base plate (23).
US08123574B2 Contact having increased resilience for use with electrical connector
A contact adapted for electrically connecting with an IC package and a printed circuit board, comprises a base portion adapted for being retained to an insulating housing, a solder portion extending from a lower end of the base portion and a turned portion bent downwardly from one end of the base portion. The solder portion is adapted for soldering the contact to the printed circuit board. The contact further includes a resilient arm extending upwardly from a bottom end of the turned portion. The resilient arm has an inclined portion and a cantilever beam. The inclined portion is connecting with the turned portion. The cantilever extends upwardly from a top end of the inclined portion and toward the turned portion to lengthen the resilient arm of the contact. Housing cavities may be formed to cause pre-loading of the resilient arms as they are inserted into the cavities.
US08123562B2 Electrical connector assembly with improved contact soldering ends
An electrical connector assembly (100) includes an insulative housing (1), a number of contacts (2) assembled in the insulative housing, a cable (4) welded with the contacts. The insulative housing includes a base portion (11), a tongue portion (12) integral with the base portion for defining a mating direction. The contacts has a number of contacting portions (212, 222) received in the tongue portion and partly extending beyond the tongue portion and a number of soldering portions (211, 221) extending rearward out of the base portion. The soldering portions include at least one pair of upper-and-lower soldering portions (26, 28, 27, 29). Each upper soldering portion opposingly faces a corresponding lower soldering portion in a vertical direction perpendicular to the mating direction. The cable is connected with respective soldering portions of the contacts.
US08123561B2 Electrical connector shielding shell
An electrical connector having a shielding shell, an insulation body clad with the shielding shell, and signal terminals received in the insulation body. The shielding shell has a first wall, and ground terminals extend towards the insertion interface and are bent towards the interior of the shielding shell from a mating side of the first wall close to the mating surface. A protection body corresponding to each ground terminal is disposed on the rust wall, and each protection body includes a guide portion located on one side of each protection body close to the insertion interface and a stopping portion extended from the guide portion. The guide portion is closer to the insertion interface than the contact portion of the ground terminal, and the height of the stopping portion is lower than that of the contact portion.
US08123555B2 Coaxial electrical connector with anti-wick system
A coaxial electrical connector includes a metallic shell having a tubular section with an axial direction and a soldering leg, a central contacts having a contacting section extending in the axial direction within the tubular section and a dielectric seat molded so as to hold together said metallic shell and the central contact as a unit. The metallic shell defines a filled groove around an inner face thereof and perpendicular to the axial direction. The filled groove is to receive a projection of the dielectric seat during a cool process of a molded process to form the coaxial electrical connector.
US08123546B2 Connector for large power transmission
A connector includes a male terminal housing with a plurality of first connecting terminals aligned and accommodated therein, a female terminal housing with a plurality of second connecting terminals aligned and accommodated therein, a plurality of isolating plates aligned and accommodated in the male terminal housing, a connecting member, and a lever mechanism including a lever to rotate a head of the connecting member so as to press the head of the connecting member against the adjacent one of the plurality of insulation plates. The lever mechanism further includes an operation permitting means that permits the connecting member to collectively fix the plurality of first connecting terminals and the plurality of second connecting terminals at the contacts, when the male terminal housing and the female terminal housing are in a predetermined fitting state.
US08123544B2 Electrical connector assembly adapted to withstand rotational movement
An electrical connector assembly, which can easily disengage a first connector from a second connector without damaging constructional elements when excessive rotational moment is exerted on the one connector when connected to the second connector, is provided. The electrical connector assembly includes a first connector and a second connector that connect with each other. The first connector includes a first housing, a first contact, and a latch. The second connector includes a second housing having a second contact and a shell attached to the second housing so as to cover the second housing.
US08123538B2 Electronic card connector
The present invention provides an electronic card connector, and intends to arrange one single testing terminal which forms a testing circuit together with an inherent conductive terminal of the electronic card connector, thereby obtaining a testing function which must be done by using two insertion pins in the prior art. Due to omitting one testing terminal, the volume of the electronic card connector is further reduced, and product assembly becomes more simply and opera table, thereby improving product efficiency, and greatly lowing manufacturing cost.
US08123535B1 Charging connector for electric vehicle
Provided is a charging connector for an electric vehicle including a connector housing having at least two terminal pin mounting openings, at least two terminal pins inserted into the terminal pin mounting openings such that front ends of the terminal pins are exposed through a front end of the connector housing, a sealing member arranged at the rear of the terminal pins in the connector housing, a support member arranged in front of the sealing member to prevent the sealing member from moving toward the front ends of the terminal pins, the support member having an outer diameter greater than an inner diameter of the sealing member, and a rear holder connected to a rear end of the connector housing in a close contact with a rear end of the sealing member, and having cable insertion openings corresponding to the terminal pins, through which a power cable is inserted.
US08123534B1 Mounting features for straddle mount connectors
A straddle mount connector includes a housing that has a mating end and a mounting end configured to be mounted to an edge of a circuit board. The housing has a top and a bottom. The housing has an upper mounting feature extending from the mounting end proximate to the top and a lower mounting feature extending from the mounting end proximate to the bottom. The upper and lower mounting features are configured to extend into an opening through the circuit board to secure the housing to the circuit board. Contacts are held by the housing and extend from the mounting end and are configured to be terminated to both sides of the circuit board. The contacts are arranged at the mating end and are configured for mating with a corresponding mating component.