| 序号 | 专利名 | 申请号 | 申请日 | 公开（公告）号 | 公开（公告）日 | 发明人 |
|---|---|---|---|---|---|---|
| 161 | Process for the preparation of thioether-substituted aromatic ketones | US88778 | 1998-06-02 | US6100431A | 2000-08-08 | Neil W. Boaz |
| The preparation of aromatic ketones substituted with a thioether group at the ortho position is accomplished by the initial reaction of an aromatic nucleus substituted with a halide and an ortho nitro group with a nitroalkane in the presence of a hydroxide base. The resulting ortho-nitroalkyl nitroarene compound is converted to the corresponding ortho-nitroaryl ketone by an oxidative Nef reaction. The aromatic nitro group of the ortho-nitroaryl ketone is replaced with a thioether group by reaction with a thiolate anion, most preferably under phase-transfer conditions. Aromatic ketones may be used to prepare various pharmaceutical and herbicidal compounds. | ||||||
| 162 | Method for preparing and selecting pharmaceutically useful sulfur-bridged bi- and triaromatic ring compounds from a structurally diverse universal library | US13362 | 1998-01-23 | US6080587A | 2000-06-27 | Michael Raymond Pavia; Harold Vernon Meyers |
| Methods for rapidly generating large rationally designed libraries of structurally-diverse small molecular weight compounds using a multicombinatorial approach. Also disclosed are compounds of the formula ##STR1## | ||||||
| 163 | Chelating agents | US833995 | 1997-04-11 | US6004529A | 1999-12-21 | Shi-Bao Yu; Jasbir Singh |
| The invention provides a complexant compound of formula IR.sup.3 S (CR.sup.1.sub.2).sub.n N(R.sup.2).sub.i (CR.sup.1.sub.2).sub.n X(CR.sup.1.sub.2).sub.n N(R.sup.2).sub.i (CR.sup.1.sub.2).sub.n SR.sup.3(I)(wherein each n, which may be the same or different, is an integer 2, 3 or 4 (preferably 2); each i, which may be the same or different, represents 0 or 1; each R.sup.3, which may be the same or different, is H or a thiol protecting group, preferably a protecting group; X is O, S, N, NR.sup.4 or a substituted phosphorus (eg. oxo substituted phosphorus), preferably S or N; each R.sup.4, which may be the same or different, is hydrogen or an optionally substituted organic group; each R.sup.1, which may be the same or different, is hydrogen or an optionally substituted organic group, or a moiety CR.sup.1.sub.2 may represents a carbonyl group or two, three or four R.sup.1 s on two different carbons together with those carbons and any intervening atoms may represent an optionally substituted saturated or unsaturated homocyclic or heterocyclic ring; and preferably, at least one CR.sup.1.sub.2 moiety is other than CH.sub.2 or CH(CH.sub.3)) or a salt or complex thereof, wherein optionally at least one of the R.sup.1, R.sup.2, R.sup.3 and R.sup.4 moieties is coupled directly or indirectly to a vector moiety. | ||||||
| 164 | Thioether-containing metal chelating compounds | US888398 | 1997-07-07 | US5932707A | 1999-08-03 | Colin Mill Archer; Gary Robert Bower; Harjit Kaur Gill; Anthony Leonard Mark Riley; Anthony Eamon Storey; Lewis Reuben Canning; David Vaughan Griffiths |
| Ligands for radiopharmaceutical use are capable of chelating radiometal species and of being bound to biological targeting molecules. The ligands have the formula (a) and (b), where A, A'=--SZ or Y, B=O or S, Y=(c), Z=H or a thiol protecting group, m=2 or 3, n=2 or 3, q=0 or 1, R=H or unsubstituted or substituted hydrocarbon and pharmaceutically acceptable salts, provided that at least one CR.sub.2 group represents CO and forms, together with an adjacent N atom; a --CONR-- amide group. ##STR1## | ||||||
| 165 | Method for production of sulfide group-containing thiol compound | US987402 | 1997-12-09 | US5919985A | 1999-07-06 | Hirokazu Itoh; Kazuaki Abe; Takashi Tomita |
| An object is to provide a method for the production of a sulfide group-containing thiol compound which comprises using a solvent capable of effecting the ring-opening addition reaction of an alkylene sulfide to a thiol compound without inducing the alkylene sulfide to polymerize. A method for the production of a sulfide group-containing thiol compound, which comprises effecting the ring-opening addition reaction of an alkylene sulfide represented by the general formula (1): ##STR1## (wherein R.sup.1, R.sup.2, R.sup.3, and R.sup.4, which may be identical or different, stand for a hydrogen atom, an alkyl group of 1 to 10 carbon atoms, or an aromatic group of 6 to 15 carbon atoms) to a thiol compound in a solvent of an amide compound or urea substituent-containing compound. | ||||||
| 166 | Process for the preparation of 3-(methylthio)propanal | US667099 | 1996-06-20 | US5905171A | 1999-05-18 | Yung C. Hsu |
| A process for the continuous preparation of 3-(methylthio)propanal. A liquid reaction medium is contacted with a gaseous acrolein feed stream in a gas/liquid contact zone. The reaction medium contains 3-(methylthio)propanal, methyl mercaptan and a catalyst for the reaction between methyl mercaptan and acrolein. The gaseous acrolein feed stream comprises acrolein vapor and non-condensable gas. Acrolein is transferred from the acrolein feed stream to the reaction medium and reacts with methyl mercaptan in that medium to produce a liquid reaction product containing 3-(methylthio)propanal. The non-condensable gas is separated from the liquid reaction product. The reaction product is divided into a product fraction and a circulating fraction, and the circulating fraction is recycled to the gas/liquid contact zone. | ||||||
| 167 | Process for continuous production of methyl mercaptan | US885044 | 1997-06-30 | US5886230A | 1999-03-23 | Willi Hofen; Wolfgang Boeck; Stephan Rautenberg; Joerg Sauer; Dietrich Arntz; Ralf Goedecke; Wolfgang Taugner; Raymund Sonnenschein |
| A process for continuous production of methyl mercaptan by catalytic reaction of methanol and hydrogen sulfide. Significant improvements in the pretreatment of the feed gas mixture and in utilization of the heat of reaction and the heat content of the product gas mixture. The energy required to vaporize the methanol is derived partly from utilization of the heat of compression of the hydrogen sulfide gas and from the heat content of the product gas leaving the reactor. The heat of reaction is utilized to heat the feed gas mixture to the reaction temperature, with the help of an external gas heater. | ||||||
| 168 | Catalytic hydrogenolysis of organic thiocyanates and disulfides to thiols | US629824 | 1996-04-10 | US5728887A | 1998-03-17 | Stephen Ernest Jacobson |
| A process for the preparation of a thiol comprising reacting hydrogen with a thiocyanate or disulfide wherein the reaction with thiocyanate is conducted in the presence of a catalyst comprising a Group VIII metal or a mixture thereof; and the reaction with thiocyanate or with disulfide is conducted in the presence of a catalyst comprising a Group VIII metal or mixture thereof in the presence of a modifier metal selected from a group consisting of Group IB, Group IIB, Group IIIA, Group IVA, Group VA and Group VIA metal or mixture thereof, said catalyst being on a porous insoluble support. | ||||||
| 169 | Process for producing 2-hydroxy-4-methylthiobutanoic acid | US178315 | 1994-01-12 | US5386056A | 1995-01-31 | Kazuyuki Matsuoka |
| Methyl 2-hydroxy-4-methylthiobutanoate and formamide are produced by means of reacting 2-hydroxy-4-methylthiobutanamide obtained by hydration of 2-hydroxy-4-methylthiobutyronitrile with methyl formate. Said methyl 2-hydroxy-4-methylthiobutanoate is hydrolyzed to give 2-hydroxy-4-methylthiobutanoic acid and methanol. No sulfuric acid is employed as a reacting agent, hence exhaustion of a large quantity of ammonium sulfate is prevented. Formamide and methanol thus produced can be recycled as reactants. | ||||||
| 170 | Process for preparing an aqueous solution of an alkali metal salt of methionine | US807664 | 1991-12-16 | US5147664A | 1992-09-15 | Claude Gillonnier; Rene Moisson |
| An aqueous solution of an alkali metal salt of methionine, which can be used as an additive in feedstuffs, is made by hydrolysis of methionine amide with an alkali metal hydroxide. | ||||||
| 171 | Diarylacetylenes, the preparation and use thereof | US561328 | 1990-08-01 | US5087637A | 1992-02-11 | Bernd Janssen; Hans-Heiner Wuest |
| Diarylacetylenes of the formula I ##STR1## where R.sup.1 is hydrogen or C.sub.1 -C.sub.4 -alkyl, R.sup.2 and R.sup.3 are each hydrogen or, when R.sup.1 is hydrogen, together form a --C(CH.sub.3).sub.2 --B--C(CH.sub.3).sub.2 -- group (where B is --CH.sub.2 Ch.sub.2 -- or --CH(CH.sub.3)--) or --OC(Ch.sub.3) (Z)CH.sub.2 CH.sub.2 -- group (where Z is C.sub.1 -C.sub.2 -alkyl) or R.sup.2 is C.sub.1 -C.sub.3 -alkoxy and R.sup.3 is C.sub.1 -C.sub.10 -alkyl or, when R.sup.2 is hydrogen, R.sup.1 and R.sup.3 are each alkyl as defined above, R.sup.4 is C.sub.1 -C.sub.6 -alkyl and n is 0, 1 or 2, are prepared as described and used as active compounds in drugs and cosmetics. | ||||||
| 172 | Preparation of 3-(alkylthio) aldehydes | US483343 | 1990-02-20 | US5015776A | 1991-05-14 | Stanley R. Sandler |
| A process for preparing 3-(C.sub.1 -C.sub.12 alkylthio) C.sub.3 -C.sub.10 aldehydes by reacting a C.sub.1 -C.sub.12 alkyl mercaptan with an .alpha.,.beta.-unsaturated aliphatic aldehyde having from 3 to 10 carbon atoms in the presence of a weakly basic exchange resin having polyamine functionality and being in the free base form, is disclosed herein. | ||||||
| 173 | Synthesis of 2-(perfluoroalkyl) ethanethiols | US141847 | 1988-01-11 | US4845300A | 1989-07-04 | Andre Lantz |
| The subject of the invention is a process for the preparation of 2-(perfluoroalkyl)ethanethiols R.sub.f CH.sub.2 CH.sub.2 SH, R.sub.f denoting a straight-chain or branched perfluoroalkyl radical containing from 2 to 20 carbon atoms. The proceses comprises reacting a 2-(perfluoroalkyl)ethyl iodide with thiourea and then decomposing the isothiouronium salt formed with an alkaline base, and is characterized in that it is carried out in a non-alcoholic inert solvent. | ||||||
| 174 | Process for preparing (hydrocarbylthio) aromatic amines | US26828 | 1987-03-17 | US4751330A | 1988-06-14 | Robert L. Davis |
| (Hydrocarbylthio)aromatic amines are prepared by reacting an aromatic amine, such as an aminobenzene, with a hydrocarbyl disulfide, such as an alkyl disulfide, in the presence of a metal or metal halide catalyst and iodine as a promoter. | ||||||
| 175 | Sulfurized compositions and lubricants containing them | US664465 | 1984-10-25 | US4584113A | 1986-04-22 | Reed H. Walsh |
| A sulfurized composition prepared by sulfurizing a mixture of at least one terpene and at least one other olefinic compound is described. More particularly, sulfurized compositions prepared by sulfurizing a mixture of pine oil and at least one other olefinic compound are described. Such sulfurized compositions are useful as lubricant additive compositions, and more particularly, as additive compositions in industrial and gear lubricants. The compositions when added to lubricants provide lubricants which exhibit improved antioxidant characteristics, nitrile seal compatibility and acceptable color characteristics. | ||||||
| 176 | Process for preparing alkaline earth metal mercaptides | US866738 | 1978-01-03 | US4177198A | 1979-12-04 | Joseph M. Bohen |
| A process for preparing alkaline earth metal mercaptides, useful as synergists for organotin stabilizers in halogen containing resins such as polyvinyl chloride, the process comprising preparing an alkaline earth metal alkoxide by reacting the metal oxide or hydroxide with an alcohol and then reacting the alkoxide with a mercaptan to provide the corresponding alkaline earth metal mercaptide, preferably while removing water from the reaction mixtures throughout the process. | ||||||
| 177 | 황화카보닐의 합성방법 및 합성반응장치 | KR1020090052782 | 2009-06-15 | KR100938435B1 | 2010-01-25 | 김대현; 김영국; 정성진; 이준열; 백두현 |
| PURPOSE: A synthesis method of carbonyl sulfide and a synthesis apparatus thereof are provided to synthesize carbonyl sulfide economically with only simple reaction equipment, to minimize the generation of by-products, and to ensure continuous mass production. CONSTITUTION: A synthesis method of carbonyl sulfide using carbon monoxide gas and liquid sulfur as a raw material comprises a step for reacting carbon monoxide gas and liquid sulfur through by bubbling and supplying carbon monoxide gas to a reactor(21) in which liquid sulfur is contained thereinside and the temperature and pressure control is enabled through a gas-solid contact method. | ||||||
| 178 | 디알킬 티오디글리콜레이트의 제조 방법 | KR1020080129773 | 2008-12-19 | KR1020090068152A | 2009-06-25 | 로데펠트,라르스; 브로다,비톨트; 좀머,요아힘; 베스텐,요아힘; 리히터,하르트무트 |
| A method for manufacturing an alkyl thiodiglycollate is provided to improve the yield comparing with conventional method. A method for manufacturing an alkyl thiodiglycollate of the chemical formula 1 comprises a step of reacting an alkyl haloacetate of the chemical formula 2 with alkali metal sulfide or alkali metal hydrogensulfide solution under the presence of phase transfer catalyst and pH 5-8 of buffer. In the chemical formulas 1 and 2, R is branch type for non-branch type alkyl radical of C1-C10; and X is chlorine or bromine atom. | ||||||
| 179 | 새로운 티올에스테르 및 그것의 이용 | KR1020007014479 | 1999-06-18 | KR100686917B1 | 2007-02-26 | 터핀,짐,에이.; 송,용성; 인만,존,케이.; 후앙,밍준; 왈크비스트,안데르스; 메이나드,앤드류; 코벨,데이비드,지.; 라이스,월리암,지.; 아펠라,에토르 |
| 본 발명은 티올에스테르의 새로운 과의 발견 및 그것의 이용에 속한다. 또한, 이 새로운 티올에스테르를 함유하는 바이러스 사멸 화합물 및 약제학적 제형을 제공한다. 본 발명은 또한, 티올에스테르-불활성화 바이러스 및 티올에스테르-복합 바이러스 단백질을 제공한다. | ||||||
| 180 | 중합체성필름 | KR1019970705672 | 1996-02-15 | KR100411922B1 | 2004-05-10 | 코테스데이비드; 그린필드시몬; 졸리페엠마제인 |
| The invention relates to a polymeric film composed of an optically anisotropic material made from a cross-linked synthetic resin composition comprising a polymer network, being obtainable by copolymerization of a mixture comprising(a) at least one monomer or oligomer, each of said monomers or oligomers having at least two polymerizable functional groups selected from the group consisting of (meth-)acrylate ester, epoxy and vinyl ether,(b) at least one achiral liquid crystalline monomer or oligomer, each of said monomersloligomers having mesogenic groups and one polymerizable functional group selected from the group consisting of (meth-)acrylate ester, epoxy and vinyl ether. | ||||||
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