| 序号 | 专利名 | 申请号 | 申请日 | 公开（公告）号 | 公开（公告）日 | 发明人 |
|---|---|---|---|---|---|---|
| 81 | (폴리)티아알킨산 화합물 및 이의 유도체, 이를 함유하는조성물 및 이의 용도 | KR1020000019762 | 2000-04-15 | KR1020010020748A | 2001-03-15 | 메낭쟝; 제나르실비; 미셸세르쥬 |
| PURPOSE: A (poly)thiaalkyne (acid) type compound is provided, which has an activity related to the transactivation of a PPAR type receptor, especially a PPAR-α-subtype receptor and is preferably useful for treating inflammatory diseases such as rheumatic arteritis, lupus and psoriasis. CONSTITUTION: A compound of the formula I: R1-Y-CH2-C equiv. C-CH2-S-CH2-R2 {Y is S(0)t £(t) is 0 to 2|, CH2, C equiv. C or C=C; R1 is a (halogenated) 1 to 18C alkyl, a 1 to 18C alkenyl, a 1 to 18C alkynyl or the like; R2 is tetrazolyl, nitrile, oxazolinyl or the like} and its derivative. For example, 3,8-dithia-5-hexadecylic acid. The compound of the formula wherein Y is methylene or a triple bond is obtained, for example, by reacting a compound of the formula: R1-X with sodium acetylide and then reacting the obtained compound of the formula: R1-C equiv. C-H as a starting raw material. When added to a cosmetic composition, the compound is preferably added in a concentration of 0.0001 to 3 wt.%. | ||||||
| 82 | 3,6,9-트리옥사운데칸-1,11-비스(3-n-도데실티오프로피오네이트)를 제조하는 방법 | KR1019880002377 | 1988-03-08 | KR1019880011093A | 1988-10-26 | 키르크우드스토퍼코트맨; 죠셉앤드루쿠츠코브스키 |
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| 83 | 사료 첨가제로서 유용한 메티오닌 알카리 금속염용액의 제조방법 | KR1019860010270 | 1986-12-02 | KR1019870005982A | 1987-07-08 | 끌로드질로니에; 르네므와송 |
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| 84 | SYNTHESIS OF ETP DERIVATIVES | PCT/US2018/033967 | 2018-05-22 | WO2018217811A1 | 2018-11-29 | HORNE, David; XIE, Jun |
Provided herein, inter alia, is the synthesis of ETP derivatives. The synthesis methods described herein include converting a ring bridging trisulfide compound to a ring bridging disulfide compound. Also provided herein are compositions, which include ring bridging trisulfide compounds and ring bridging disulfide compounds. |
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| 85 | COMPOSITIONS AND METHODS FOR IMAGING TISSUES, ORGANS AND TUMORS | PCT/US2010/038443 | 2010-06-13 | WO2010144891A1 | 2010-12-16 | MAHMOOD, Ashfaq; JONES, Alun, G.; LIMPA-AMARA, Naengnoi; PENG, Yijie; AKGUN, Zeynep |
The present invention relates to compounds and related technetium and rhenium complexes thereof which are suitable for imaging or therapeutic treatment of tissues, organs, or tumors. In another embodiment, the invention relates to methods of imaging tissues, organs, or tumors using radiolabeled metal complexes, particularly tissues, organs, or tumors which express certain receptors to which the compounds or complexes of the invention have an affinity. The present invention also relates to methods of treating cancer, particularly those cancer lines which express certain receptors to which the compounds or complexes of the invention have an affinity. In yet another embodiment, the present invention provides methods of imaging and/or inhibiting receptors or neuroreceptors using compounds or complexes of the invention which have an affinity for the receptor or neuroreceptor to be imaged and/or inhibited. |
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| 86 | METHODS OF TREATING A BOTULINUM TOXIN RELATED CONDITION IN A SUBJECT | PCT/US2009/055061 | 2009-08-26 | WO2010033360A1 | 2010-03-25 | JACOBSON, Alan; MOE, Scott |
The present invention provides methods of treating a botulinum toxin related condition in a subject. In certain embodiments, the methods involve administering a compound of the following formulas:(I), (II), (III), (IV), (V). |
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| 87 | METHODS AND COMPOSITIONS FOR PRODUCING DIFLUOROMETHYLENE-AND TRIFLUOROMETHYL-CONTAINING COMPOUNDS | PCT/US2008/086044 | 2008-12-09 | WO2009076345A1 | 2009-06-18 | UMEMOTO, Teruo; SINGH, Rajendra |
New methods for producing difluoromethylene-containing compounds with phenylsulfur trifluoride or a primary alkyl-substituted phenylsulfur trifluoride are disclosed. Also, new methods for producing trifluoromethyl-containing compounds with phenylsulfur trifluoride or primary alkyl-substituted phenylsulfur trifluoride are also disclosed. |
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| 88 | COMPOSITIONS AND METHODS FOR TREATING INFLAMMATORY CONDITIONS | PCT/US2006/023022 | 2006-06-13 | WO2006135894A1 | 2006-12-21 | STOCK, Jeffry, B.; GORDON, Joel; STOCK, Maxwell; STOCK, Gregory |
The present invention relates to compositions containing signal transduction modulator compounds, to methods for treating or preventing inflammation, or promoting healthy joints, using the compounds and to kits for the same. |
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| 89 | PROCESS FOR THE DEPROTECTION OF PROTECTED THIOLS | PCT/GB2000/002796 | 2000-07-19 | WO01005757A2 | 2001-01-25 | |
| The synthesis of peptides comprising disulphide bridges is challenging since it is difficult to ensure that the correct cysteine residues combine to form the desired disulphide bridges. The present invention describes novel protection techniques useful in the preparation of peptides. Described is a process for the deprotection of an Acm-, MBzl- and/or tBu-protected thiol which comprises reacting said protected thiol with an acid in the presence of an oxidising agent at a temperature sufficient to effect deprotection and generation of disulphide bonds. | ||||||
| 90 | HYDROXYTHIOL GRIGNARD REACTION SYNTHESIS | PCT/US1999/030309 | 1999-12-17 | WO00035866A2 | 2000-06-22 | |
| A method for the preparation of hydroxythiol compounds by reacting a hydroxyl-protected halide compound having the structure: X-R-OPg with magnesium in a Grignard-suitable solvent to form a hydroxyl-protected magnesium halide compound, wherein R is selected from substituted or unsubstituted aliphatic radicals, substituted or unsubstituted cyclic aliphatic radicals, substituted or unsubstituted aromatic radicals, substituted or unsubstituted araliphatic radicals and substituted or unsubstituted heterocyclic radicals; Pg is a protecting group; and X is selected from the group consisting of F, Cl, Br and I; then reacting said hydroxyl-protected magnesium halide compound with sulfur in the Grignard-suitable solvent to form a hydroxyl-protected thiomagnesium halide compound; and hydrolyzing the protected hydroxyl group to form a hydroxythiomagnesium halide compound and converting the thiomagnesium halide to a thiol, wherein the protecting group is selected so that species formed by the de-protection of the protecting group are inert toward thiols, or the method further includes the step of removing the protecting group species formed by de-protection of the hydroxyl group from the reaction mixture before converting the thiomagnesium halide to a thiol. | ||||||
| 91 | VINYL SUBSTITUTED CYCLIC PRODUCTS OF THE ENE-YNE REACTION | PCT/US1999/019622 | 1999-08-26 | WO00012515A1 | 2000-03-09 | |
| This invention relates to a novel intermediate for use in solid phase chemistry, its preparation and methods of use of the intermediate. | ||||||
| 92 | NAALADASE INHIBITORS USEFUL AS PHARMACEUTICAL COMPOUNDS AND COMPOSITIONS | PCT/US1999/015128 | 1999-07-02 | WO00001668A2 | 2000-01-13 | |
| The present invention relates to N-Acetylated alpha -Linked Acidic Dipeptidase (NAALADase) inhibitors enzyme activity, pharmaceutical compositions comprising such inhibitors, and methods of their use to inhibit NAALADase enzyme activity, thereby effecting neuronal activities, inhibiting angiogenesis, and treating glutamate abnormalities, compulsive disorders, prostate diseases, pain and diabetic neuropathy. | ||||||
| 93 | Process for the purification of acrolein | US16520384 | 2019-07-24 | US10556850B1 | 2020-02-11 | Thorsten Merker; Martin Koerfer; Michael Eicker; Bruno Krudewig; Rainer Malzkorn; Haohao Zhu |
| The present invention relates to a process for purifying acrolein. The process includes the steps of a) splitting a liquid feed stream containing acrolein into at least a first liquid stream and a second liquid stream, b) introducing the first liquid stream with a temperature T1 into a distillation column at a point between the top and the bottom of the distillation column, c) introducing the second liquid stream with a temperature T2 into the distillation column at the top of the distillation column, d) withdrawing an overhead vapor stream enriched in acrolein from the distillation column, and e) withdrawing a bottom stream depleted in acrolein. The temperature T2 of the second liquid stream in step c) is lower than the temperature T1 of the first liquid stream in step b). | ||||||
| 94 | Mixed decyl mercaptans compositions and use thereof as mining chemical collectors | US15284809 | 2016-10-04 | US09527090B1 | 2016-12-27 | Jim D. Byers; Michael S. Matson; Jason L. Kreider |
| Disclosed herein is a process for the recovery of a metal from an ore using a collector composition. The process includes contacting the ore with the collector composition. The collector composition can include sulfur-containing compounds comprising (i) mercaptans comprising branched C10 mercaptans compounds selected from the group consisting of 5-methyl-1-mercapto-nonane, 3-propyl-1-mercapto-heptane, 4-ethyl-1-mercapto-octane, 2-butyl-1-mercapto-hexane, 5-methyl-2-mercapto-nonane, 3-propyl-2-mercapto-heptane, 4-ethyl-2-mercapto-octane, 5-methyl-5-mercapto-nonane, and combinations thereof; and (ii) sulfides comprising branched C20 sulfides represented by the structure R1—S—R2, wherein R1 and R2 are each independently a functional group derived from an olefin, wherein the olefin comprises 5-methyl-1-nonene, 3-propyl-1-heptene, 4-ethyl-1-octene, 2-butyl-1-hexene, or combinations thereof. | ||||||
| 95 | Thio compounds and preparing method of the same | US13394730 | 2010-08-31 | US09024073B2 | 2015-05-05 | Hyung Jae Lee; Chang Kyo Shin; Jin Eok Kim |
| Provided are novel thio compounds and a method for preparing the same. More particularly, there is provided a novel thio compound prepared by reacting an alkylation product of p-cresol and dicyclopentadiene with mercaptan and paraformaldehyde. Unlike existing antioxidants such as 2,6-di-t-butyl-4-methylphenol (BHT) being harmful to the human body due to the high volatility, the novel thio compounds of the present invention, which have the low volatility because of their high molecular weight, give no harm to the human body. Further, with excellent performances, they are suitable to replace the existing antioxidants. | ||||||
| 96 | Nanoparticles and nanoparticle compositions | US13640698 | 2011-04-08 | US08790621B2 | 2014-07-29 | Yan Zhao |
| The invention provides multivalent surface-crosslinked micelle (SCM) particles, crosslinked reverse micelle (CRM) particles, and methods of making and using them. The SCM particles can be used, for example, to inhibit a virus or bacteria from binding to a host cell. The inhibition can be used in therapy for the flu, cancer, or AIDS. The CRM particles can be used, for example, to prepare metal nanoparticles or metal alloy nanoparticles, or they can be used in catalytic reactions. | ||||||
| 97 | Immobilized heteropoly acids and the use of the same for electrode stabilization and enhancement | US12122529 | 2008-05-16 | US08753997B2 | 2014-06-17 | Ronald Justin Stanis; Andrew Michael Herring; Mei-Chen Kuo; Jack Richard Ferrell, III |
| The use of fuel cells to produce electricity are known as an environmentally clean and reliable source of energy, and show promise as an automotive power source if the polymer electrolyte membrane fuel cell can be made less expensive, more durable, reduce or eliminate humidification of the reactive gases, and operate at temperatures encountered during automotive operating conditions. The use of an electro-catalyst formed from heteropoly acids immobilized by a conductive material, such as carbon or platinum black, and stabilizing a metallic black with the immobilized conductive material addressed these automotive fuel cell needs. Coating the fuel cell electrode, polymer electrolyte assembly with a nano-particle catalyst derived from a heteropoly acid provided anodic carbon monoxide tolerance at anodic overpotentials and an active cathodic oxygen reduction. The heteropoly acids can also function as supercapacitor electrode films. | ||||||
| 98 | Substituted phenylsulfur trifluoride and other like fluorinating agents | US12886286 | 2010-09-20 | US08710270B2 | 2014-04-29 | Teruo Umemoto |
| Novel substituted phenylsulfur trifluorides that act as fluorinating agents are disclosed. Also disclosed are methods for their preparation and methods for their use in introducing one or more fluorine atoms into target substrate compounds. Finally, various intermediate compounds for use in preparing substituted phenylsulfur trifluorides are provided. | ||||||
| 99 | Bis-aromatic anticancer agents | US12936608 | 2009-04-06 | US08686190B2 | 2014-04-01 | Ahmad Safavy |
| Treatment of cancer includes administering a compound of formula (I) to a subject. In particular, treatment of colorectal cancer is described. | ||||||
| 100 | Derivatisation of biological molecules | US12527233 | 2008-02-12 | US08575397B2 | 2013-11-05 | Stephen James Brocchini; Antony Robert Godwin; Yiqing Tang; Andrew Lennard Lewis |
| The present disclosure relates to a new polymerization process in which ethylenically unsaturated monomers are polymerised by a living radical polymerization process in the presence of an initiator and a catalyst. Polymers produced by this new process are also thought to be novel and may be used to derivatise biological molecules to improve their efficacy as therapeutic treatments. A preferred polymer is of formula The polymers are particularly suitable for derivatising proteins, such as interferon-α. | ||||||
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