| 序号 | 专利名 | 申请号 | 申请日 | 公开（公告）号 | 公开（公告）日 | 发明人 |
|---|---|---|---|---|---|---|
| 1 | 石灰氮一次性水解的工艺方法 | CN201610665703.5 | 2016-08-13 | CN106278948A | 2017-01-04 | 王先武; 钱潮涌; 金斐; 王利平; 张飞 |
| 本发明公开了石灰氮一次性水解的工艺方法，主要包括：(1)向水解釜中投入石灰氮和水，再从水解釜底部缓慢通入气体二氧化碳，控制温度在26-35℃，反应过程中随时监测水解釜内的pH，控制PH值在8-9；(2)将步骤1中所有物料通过压滤机进行压滤，压滤后的滤液即为液态单氰胺钙盐，再将其抽至胺化釜，向胺化釜里滴加氯甲酸甲酯，不断搅拌，即可合成氰胺基甲酸甲酯钙盐。本发明通过一次性水解降低甲酯消耗，消除危险固废，减少二氧化碳排放，甲酯消耗降低10％以上，酯化釜效率增加2倍。 | ||||||
| 2 | 新的羟肟酸衍生物 | CN96194830.2 | 1996-03-29 | CN1187810A | 1998-07-15 | 桐尾佳惠; 前田贵子; 佐佐木则雄; 外岛德重; 泽井伸光; 布鲁斯·米利根; 约瑟夫·佩雷斯; 让-彼埃尔·沃尔斯; 丹尼尔·B·甘特 |
| 通式(Ⅰ)的羟肟酸衍生物,其中G是下式的G1或G2或G3或G4:R5OC=C(COOR4)－、R5ON=C(COOR4)－、R5ON=C(CONR6R7)、R5OC=C(CONR6R7)－,X1、X2、X3是H、卤素、HO、巯基、硝基、SCN、叠氮基、CN、烷基、卤代烷基、氰基烷基、烷氧基、卤代烷氧基、氰基烷氧基、烷基硫代、卤代烷基硫代、氰基烷基硫代、烷基亚磺酰基、卤代烷基亚磺酰基、烷基磺酰基、卤代烷基磺酰基、环烷基、卤代环烷基、烯基、炔基、烯氧基、炔氧基、烯基硫代、炔基硫代、氨基、烷基氨基、二烷基氨基、酰基氨基、烷氧羰基、N－烷基氨基甲酰基、N,N－二烷基氨基甲酰基、N－烷基氨磺酰基、N,N－二烷基氨磺酰基,R1、R2是H或烷基、卤代烷基、环烷基、卤代环烷基、氰基、烷氧基烷基、烷氧基羰基;或R1和R2可以在一起形成二价基团,R3是H或烷基、卤代烷基、环烷基、卤代环烷基、烯基、炔基、烷氧基烷基、烷基硫代烷基、氰基烷基、卤代烷氧基烷基、二烷基氨基烷基、任选取代的苯基、任选取代的苄基,W是O、S、SO或SO2,R4、R5是烷基,R6、R7是H或烷基。 | ||||||
| 3 | 一种环合剂N-（甲氧基羰基）亚氨基甲酸二甲酯及利用该环合剂合成芬苯达唑的方法 | CN202310767018.3 | 2023-06-27 | CN116496181A | 2023-07-28 | 潘鹏; 程贺; 樊竹叶 |
| 本发明公开了一种环合剂N‑（甲氧基羰基）亚氨基甲酸二甲酯及利用该环合剂合成芬苯达唑的方法，涉及芬苯达唑及其中间体的制备技术领域，亚氨基碳酸二甲酯在碱催化作用下失去质子，增加了N原子的亲核能力，与氯甲酸甲酯接触时，N原子进攻羰基碳，形成中间体，后氯原子在钠离子作用下从中间体中脱落，得到环合剂N‑（甲氧基羰基）亚氨基甲酸二甲酯，用环合剂N‑（甲氧基羰基）亚氨基甲酸二甲酯与4‑苯硫基邻苯二胺反应，得到的芬苯达唑，反应过程中避免使用过多的有机溶剂及有机碱，有效降低了生产成本，环合剂N‑（甲氧基羰基）亚氨基甲酸二甲酯生产过程中只产生钠盐，不产生铵盐，降低了后期的处理成本和处理难度，对环境友好。 | ||||||
| 4 | 一种N-氰亚胺碳酸二酯的合成方法 | CN201510289901.1 | 2015-05-29 | CN104860848B | 2016-03-09 | 马向东; 黄伟; 杨毅跃 |
| 一种N-氰亚胺碳酸二酯的合成方法，包括以下步骤：(1)四氯化碳与碱金属醇化合物发生亲核取代反应，生成二氯二氧烷基甲烷、一氯三氧烷基甲烷或四氧烷基甲烷；(2)N-氰亚胺碳酸二酯粗品制备：二氯二氧烷基甲烷在碱性条件下与单氰胺反应生成N-氰亚胺碳酸二酯和氯化物，或者一氯三氧烷基甲烷在碱性条件下与单氰胺反应生成N-氰亚胺碳酸二酯和氯化物，或者四氧烷基甲烷在碱性条件下与单氰胺反应生成N-氰亚胺碳酸二酯；(3)N-氰胺碳酸二酯粗品精制。本发明与现有N-氰胺碳酸二酯的生产工艺相比，摒弃了使用氯气、氰化物等剧毒原辅料，而且工艺操作简单、环境友好，适合大规模工业化生产。 | ||||||
| 5 | 一种石灰氮一次性水解的工艺 | CN201510325122.2 | 2015-06-11 | CN104961655A | 2015-10-07 | 袁晓林; 储兵兵; 陈建平; 李永华; 吴双齐; 查日飞; 高焰兵 |
| 本发明提供了一种石灰氮一次性水解的工艺，首先在水解反应釜内添加石灰氮，同时向水解反应釜内不断通入含有氮气和二氧化碳混合气体，再向水解反应釜内滴加质量比为1～2：1的水和浓度为5-15％的甲醇溶液，此时釜内的PH值为6.5-6.8，不断搅拌。本发明采用单氰胺生产技术，使得石灰氮一次水解得以实现，由于提供了高品质的氰胺液，在滴氰胺基甲酸甲酯的过程中可减少氰胺基甲酸甲酯的滴入量，降低了消耗，为连续化生产打好基础；极大的提高了水解釜的效率，减少了压滤机的工作时间，降低了甲酯的消耗，为氢氰胺基液的生产提高了连续生产的可行，甲酯消耗降低5％以上，酯化釜效率增加1.5倍。 | ||||||
| 6 | 一种环合剂N-（甲氧基羰基）亚氨基碳酸二甲酯及利用该环合剂合成芬苯达唑的方法 | CN202310767018.3 | 2023-06-27 | CN116496181B | 2023-09-01 | 潘鹏; 程贺; 樊竹叶 |
| 本发明公开了一种环合剂N‑（甲氧基羰基）亚氨基碳酸二甲酯及利用该环合剂合成芬苯达唑的方法，涉及芬苯达唑及其中间体的制备技术领域，亚氨基碳酸二甲酯在碱催化作用下失去质子，增加了N原子的亲核能力，与氯甲酸甲酯接触时，N原子进攻羰基碳，形成中间体，后氯原子在钠离子作用下从中间体中脱落，得到环合剂N‑（甲氧基羰基）亚氨基碳酸二甲酯，用环合剂N‑（甲氧基羰基）亚氨基碳酸二甲酯与4‑苯硫基邻苯二胺反应，得到的芬苯达唑，反应过程中避免使用过多的有机溶剂及有机碱，有效降低了生产成本，环合剂N‑（甲氧基羰基）亚氨基碳酸二甲酯生产过程中只产生钠盐，不产生铵盐，降低了后期的处理成本和处理难度，对环境友好。 | ||||||
| 7 | 一种石灰氮一次性水解的工艺 | CN201510325122.2 | 2015-06-11 | CN104961655B | 2017-01-18 | 袁晓林; 储兵兵; 陈建平; 李永华; 吴双齐; 查日飞; 高焰兵 |
| 本发明提供了一种石灰氮一次性水解的工艺，首先在水解反应釜内添加石灰氮，同时向水解反应釜内不断通入含有氮气和二氧化碳混合气体，再向水解反应釜内滴加质量比为1～2：1的水和浓度为5-15％的甲醇溶液，此时釜内的PH值为6.5-6.8，不断搅拌。本发明采用单氰胺生产技术，使得石灰氮一次水解得以实现，由于提供了高品质的氰胺液，在滴氰胺基甲酸甲酯的过程中可减少氰胺基甲酸甲酯的滴入量，降低了消耗，为连续化生产打好基础；极大的提高了水解釜的效率，减少了压滤机的工作时间，降低了甲酯的消耗，为氢氰胺基液的生产提高了连续生产的可行，甲酯消耗降低5％以上，酯化釜效率增加1.5倍。 | ||||||
| 8 | 一种N-氰亚胺碳酸二酯的合成方法 | CN201510289901.1 | 2015-05-29 | CN104860848A | 2015-08-26 | 马向东; 黄伟; 杨毅跃 |
| 一种N-氰亚胺碳酸二酯的合成方法，包括以下步骤：(1)四氯化碳与碱金属醇化合物发生亲核取代反应，生成二氯二氧烷基甲烷、一氯三氧烷基甲烷或四氧烷基甲烷；(2)N-氰亚胺碳酸二酯粗品制备：二氯二氧烷基甲烷在碱性条件下与单氰胺反应生成N-氰亚胺碳酸二酯和氯化物，或者一氯三氧烷基甲烷在碱性条件下与单氰胺反应生成N-氰亚胺碳酸二酯和氯化物，或者四氧烷基甲烷在碱性条件下与单氰胺反应生成N-氰亚胺碳酸二酯；(3)N-氰胺碳酸二酯粗品精制。本发明与现有N-氰胺碳酸二酯的生产工艺相比，摒弃了使用氯气、氰化物等剧毒原辅料，而且工艺操作简单、环境友好，适合大规模工业化生产。 | ||||||
| 9 | 制备2－烷氧基－6－(三氟甲基)嘧啶－4－酚的方法 | CN200710181206.9 | 2004-02-02 | CN101255125A | 2008-09-03 | 比特·施米特; 劳伦特·达克里; 麦克尔·戈特施波纳; 布鲁诺·里特内尔 |
| 本申请涉及制备2－烷氧基－6－(三氟甲基)嘧啶－4－酚的方法。制备下式III的亚氨碳酸二烷基酯的方法，其中R1、R2为C1－C8烷基，包括使氯化氰C1－CN与至少一种其中R是R1或R2的C1－C8醇ROH反应的步骤，并且其中醇包括悬浮形式的固体氢氧化物。 | ||||||
| 10 | 海绵动物抗肿瘤化合物 | CN01809444.9 | 2001-03-20 | CN1429203A | 2003-07-09 | 田中淳一; 比嘉辰雄 |
| 分离自海绵动物的新抗肿瘤化合物，如式(1)、(2)、(3)和(4)所示。 | ||||||
| 11 | New fluorinated alkoxy imines and their N-chloro- and N-bromo-derivatives, and process for their preparation | US677173 | 1991-03-29 | US5118844A | 1992-06-02 | Darryl D. Desmarteau; Stefan P. Kotun |
| The present invention relates to novel fluorinated alkoxyimines having the formula:R.sub.x --CF.dbd.N--O--CZ.sub.1 Z.sub.2 --CF.sub.3 (I)wherein:R.sub.x is either F or a perhalogenated alkyl group containing from 1 to 3 carbon atoms, andZ.sub.1 and Z.sub.2, either equal to, or different from, each other, are F, Cl, Br, H or a perfluorinated alkyl group containing from 1 to 3 carbon atoms.They are prepared by reacting a fluorinated alkoxyamine haivng the formula:R.sub.x --CF.sub.2 --NH--O--CZ.sub.1 Z.sub.2 --CF.sub.3 (V)with KF at a temperature comprised within the range of from 0.degree. C. to 100.degree. C.The present invention relates furthermore to the N-chloro- and N-bromo-derivatives of said fluorinated alkoxyimines (I), which derivatives have the formulae:R.sub.x --CF.sub.2 --NCl--O--CZ.sub.1 Z.sub.2 CF.sub.3 (VII)andR.sub.x --CF.sub.2 --NBr--O--CZ.sub.1 Z.sub.2 --CF.sub.3 (VIII). | ||||||
| 12 | Preparation of dialkyl (N-cyanoimido)carbonates from dialkyl imidocarbonates and cyanogen halides | US823518 | 1992-01-21 | US5237084A | 1993-08-17 | Michael A. Oliver; Ward H. Oliver |
| Dialkyl (N-cyanoimido) carbonates are prepared in good yield in a non-aqueous solvent by a process which comprises either (a) adding a cyanogen halide at a controlled rate to a reactor containing an unsubstituted or substituted dialkyl imidocarbonate, an inorganic base and/or a trialkyl amine, or (b) by adding a trialkyl amine to a solution of the unsubstituted or substituted dialkyl imidocarbonate and a cyanogen halide. The dialkyl imidocarbonate precursors are prepared by using a stoichiometric ratio (2:1) of alcohol to cyanogen halide in the presence of an acid acceptor and in a non-aqueous solvent.Dialkyl (N-cyanoimido)carbonates are useful as intermediates for pesticides and pharmaceuticals. | ||||||
| 13 | Fluorinated alkoxyimines and their N-chloro- and N-bromo-derivatives, and process for their preparation | US692960 | 1991-04-26 | US5081299A | 1992-01-14 | Darryl D. DesMarteau; Stefan P. Kotun |
| Novel fluorinated alkoxy imines having the formula:R.sub.x --CF.dbd.N--O--CZ.sub.1 Z.sub.2 --CF.sub.3 (I)wherein:R.sub.x is either F or a perhalogenated alkyl group containing from 1 to 3 carbon atoms, andZ.sub.1 and Z.sub.2, either equal to, or different from, each other, are F, C1, Br, H or a perfluorinated alkyl group containing 1 to 3 carbon atoms. They are prepared by reacting a fluorinated alkoxy-amine having the formula:R.sub.x --CF.sub.2 --NH--O--CZ.sub.1 Z.sub.2 --CF.sub.3 (V)with Kf at a temperature within the range of from 0.degree. to 100.degree. C. Furthermore, N-chloro- and N-bromo-derivatives of said fluorinated alkoxy-imines (I) are provided, which derivatives have the formulae:R.sub.x --CF.sub.2 --NCl--O--CZ.sub.1 Z.sub.2 --CF.sub.3 (VII)andR.sub.x --CF.sub.2 --NBr--O--CZ.sub.1 Z.sub.2 --CF.sub.3 (VIII) | ||||||
| 14 | Preparation of fungicidal quinazolinones and useful intermediates | US202394 | 1998-12-09 | US6166208A | 2000-12-26 | James Francis Bereznak; Eric Allen Marshall; Charlene Gross Sternberg; Jeffrey Arthur Sternberg; King-Mo Sun |
| This invention provides advantageous processes for preparing quinazolinones of Formula I ##STR1## wherein: R.sup.1 is C.sub.1 -C.sub.10 alkyl; C.sub.3 -C.sub.10 alkenyl; C.sub.3 -C.sub.10 cycloalkyl; C.sub.3 -C.sub.10 halocycloalkyl; C.sub.4 -C.sub.10 cycloalkylalkyl; C.sub.4 -C.sub.10 halocycloalkylalkyl; or C.sub.3 -C.sub.10 alkynyl;R.sup.2 is C.sub.1 -C.sub.10 alkyl; C.sub.3 -C.sub.10 alkenyl; C.sub.3 -C.sub.10 cycloalkyl; C.sub.3 -C.sub.10 halocycloalkyl; C.sub.4 -C.sub.10 cycloalkylalkyl; C.sub.4 -C.sub.10 halocycloalkylalkyl; C.sub.4 -C.sub.10 cycloalkyl; C.sub.4 -C.sub.10 halocycloalkyl; or C.sub.3 -C.sub.10 alkynyl; andR.sup.3 and R.sup.4 are each independently hydrogen or halogen; from compounds containing the moiety IIg ##STR2## This invention further provides certain compounds of Formula II, IIIa, or IVa ##STR3## where R.sup.7 is C.sub.2 -C.sub.6 alkyl. | ||||||
| 15 | Process for the preparation of N-cyanoimidocarbonates | US914268 | 1992-07-15 | US5208351A | 1993-05-04 | Franz Thalhammer; Stefan Weiss |
| The present invention provides a process for the preparation of N-cyanoimidocarbonates of the general formula: ##STR1## in which R.sup.1 and R.sup.2 are the same and are alkyl radicals containing up to 4 carbon atoms or R.sup.1 and R.sup.2 are joined together to give an ethylene or propylene chain which is optionally substituted by an alkyl radical containing up to 3 carbon atoms, wherein an imidocarbonate obtained in aqueous alkaline solution from the appropriate alcohol and cyanogen chloride is added with an acid to an aqueous solution of cyanamide in such a manner that the reaction mixture has a pH value of from 3 to 8. | ||||||
| 16 | Sponge anti-tumor compounds | JP2001568888 | 2001-03-20 | JP2003528075A | 2003-09-24 | 辰雄 比嘉; 淳一 田中 |
| (57)【要約】 海綿より単離された、新規な抗腫瘍化合物は、下式（１）、（２）、（３）、及び（４）： 【化１】 | ||||||
| 17 | Production method of N- cyan imide carbonate | JP18912092 | 1992-07-16 | JP3162488B2 | 2001-04-25 | ヴァイス シュテファン; タールハンマー フランツ |
| 18 | Preparation of dialkyl (n-cyanoimido)carbonate | JP18633692 | 1992-06-19 | JPH05186412A | 1993-07-27 | MAIKERU EE ORIBUAA; UOODO EICHI ORIBUAA |
| PURPOSE: To obtain a dialkyl (N-cyanoimido)carbonate useful as an intermediate of a pesticide or pharmaceuticals with a high yield in a nonaq. solvent system in which the isolation (extraction) of an intermediate product is not necessary without using expensive unstable cyanamide. CONSTITUTION: A cyanogen halide, preferably cyanogen chloride or cyanogen bromide is allowed to react with an optionally substd. dialkyl imidocarbonate, preferably a compd. of formula I (wherein R 1 and R 2 are each a 1-6C alkyl, etc., which may have a substituent such as a 1-3C alkoxy, etc., preferably 1-3C alkyl) at -20 to +40°C, preferably -10 to +10°C in a nonaq. solvent, preferably tert. butyl methyl ether, THF, acetone or methylene chloride in the presence of a catalytic amt. of a trialkylamine, preferably trimethylamine or triethylamine and an inorg. salt, preferably an alkali metallic carbonate. The objective optionally substd. dialkyl (N-cyanoimido)carbonate, preferably a compd. of formula II is advantageously obtd. COPYRIGHT: (C)1993,JPO | ||||||
| 19 | Method of manufacturing a dialkyl (n- cyanoimido) carbonate | JP18633692 | 1992-06-19 | JP3165871B2 | 2001-05-14 | エイチ． オリヴァー ウォード; エー． オリヴァー マイケル |
| 20 | JPH0579665B2 - | JP6026684 | 1984-03-27 | JPH0579665B2 | 1993-11-04 | TOMIOKA HIROKI; OOISHI TADASHI; TAKAHASHI JUNYA; SASAKI MITSURU; HIRATA NAONORI |
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