| 序号 | 专利名 | 申请号 | 申请日 | 公开（公告）号 | 公开（公告）日 | 发明人 |
|---|---|---|---|---|---|---|
| 101 | Materials and methods for the treatment of celiac disease | US11925522 | 2007-10-26 | US08034776B2 | 2011-10-11 | Alessio Fasano; Blake Paterson |
| The present invention provides materials and methods for the treatment of celiac disease. In addition, the present invention provides materials and methods of monitoring the treatment of a subject having celiac disease. | ||||||
| 102 | Peptides for diagnostic and therapeutic methods for celiac sprue | US11198068 | 2005-08-04 | US07462688B2 | 2008-12-09 | Chaitan Khosla; Jiang Xia; Matthew John Siegel |
| Detection of toxic gluten oligopeptides refractory to digestion and antibodies and T cells responsive thereto can be used to diagnose Celiac Sprue. Analogs of such oligopeptides are useful in the inhibition of immune responses. | ||||||
| 103 | COMPOSITIONS AND METHODS FOR TREATING CELIAC SPRUE DISEASE | EP14756186.4 | 2014-08-13 | EP3033100A1 | 2016-06-22 | SIEGEL, Justin Bloomfield; BAKER, David; PULTZ, Ingrid Swanson |
| The invention provides compositions and methods for treating celiac sprue. | ||||||
| 104 | COMPOSITIONS AND METHODS FOR TREATMENT OF CELIAC DISEASE | EP09828453.2 | 2009-11-30 | EP2367561B1 | 2015-05-20 | ANDERSON, Robert, Paul; STEWART, Jessica, Anne; DROMEY, James, Anthony; TYE-DIN, Jason, Allan |
| 105 | ANTI-GLUTEN EGG YOLK ANTIBODIES FOR THE TREATMENT OF CELIAC DISEASE | EP05735623.0 | 2005-04-18 | EP1765395B1 | 2011-02-09 | SUNWOO, Hoon; SIM, Jeong S. |
| Compositions, food products or beverages for ameliorating the syptoms of celiac disease or gluten sensitive enteropathy comprising egg yolk antibodies against gluten, including gliadin, high molecular glutenin, low molecular glutenin and mixtures of the three peptides. The antibodies may be produced by immunizing egg laying fowl with immunogenic preparations of gluten and harvesting the eggs and egg yolks. | ||||||
| 106 | TREATMENT OF CEREAL FLOUR AND SEMOLINA FOR CONSUMPTION BY CELIAC PATIENTS | EP07848833.5 | 2007-10-29 | EP2094860A2 | 2009-09-02 | ROSSI, Mauro; GIANFRANI, Carmela; SICILIANO, Rosa Anna |
| The present invention relates to the use of an enzymatic method for treating flour, semolina and protein extracts derived from cereals known to stimulate a pathological immune response in patients affected by Celiac Disease (CD). Said treatment drastically reduces or completely eliminates the toxicity of gluten or similar products derived from other cereals. The method uses the catalytic activity of microbial transglutaminase and, in particular, its ability to bind proteins in cereal flour or semolina to an alkylated (C1-C4) derivative of lysine. After the treatment said proteins extracted from flour show a substantially lowered immuno-stimulatory activity in celiac patients T lymphocytes. | ||||||
| 107 | PEPTIDES AND USES THEREOF FOR THERAPY OF CELIAC DISEASES | EP97900735.8 | 1997-01-16 | EP0876399B1 | 2002-04-24 | DE VINCENZI, Massimo |
| Protein compound having a sequence comprised in the proteins of durum wheat and being not toxic for celiac subjects for use in medicine and diagnosis, preferably having an aminoacid sequence comprised in the following sequence: QQPQDAVQPF, or substantially homologous so as to retain the functional activity. Also a method for the identification of molecules having a protective activity towards celiac and celiac related disease affected subjects. | ||||||
| 108 | TREATMENT OF CELIAC DISEASE WITH INTERLEUKIN-15 ANTAGONISTS | EP99933001.2 | 1999-07-09 | EP1096949A2 | 2001-05-09 | LONDEI, Marco; QUARATINO, Sonia; MAIURI, Luigi |
| The invention relates to the treatment of inflammatory bowel diseases, such as celiac disease with interleukin-15 (IL-15) antagonists. Preferably the antagonists are muteins of IL-15, antibodies against IL-15 or IL-15 molecules bound to chemical groups that interfere with the ability of IL-15 to effect a signal transduction through either the β or η-subunit of the IL-15 receptor complex, but which do not interfere with IL-15 binding to IL-15Rα. | ||||||
| 109 | GETRÄNKE FÜR ZÖLIAKIEPATIENTEN UND GLUTEN/GLIADIN-SENSITIVE PERSONEN UND VERFAHREN ZUR HERSTELLUNG | PCT/EP2008/050647 | 2008-01-21 | WO2008090126A1 | 2008-07-31 | MARX, Stefan; OTTERBACH-NOÄ, Jens; LANGER, Olaf; ZOTZEL, Jens |
Verfahren zur Herstellung eines Getränkes, eines Getränkegrundstoffs, eines Getränkekonzentrates oder eines Getränkezusatzes mit vermindertem Gehalt an Prolaminfragmente aus prolaminhaltigen Rohstoffen mit folgenden Schritten: a) Inkontaktbringen des Getränkes oder einer Vorstufe des Getränks mit quervernetzenden Enzymen, um modifizierte Prolaminfragmente zu erhalten, b) mindestens teilweise Entfernung der modifizierten Prolaminfragmente. |
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| 110 | COMPOUNDS FOR THE SELECTIVE TREATMENT OF THE INTESTINAL IMMUNO-INFLAMMATORY COMPONENT OF THE CELIAC DISEASE | EP08863709.5 | 2008-12-23 | EP2222291B1 | 2012-03-21 | BARONI, Sergio; BELLINVIA, Salvatore |
| In one aspect, the present invention relates to amino-salicylic - aminophenylpropionic compounds for the use in the treatment of the inflammatory component of the celiac disease. These compounds act by blocking the cytokines released in the celiac disease and are specifically useful in the treatment of cases refractory to the diet, in dietary errors and in the reduction of the celiac disease remission time. | ||||||
| 111 | THERAPEUTIC ENZYME FORMULATIONS AND USES THEREOF | EP05714080.8 | 2005-02-23 | EP1740197A1 | 2007-01-10 | SHAN, Lu; BETHUNE, Michael; KHOSLA, Chaitan; GASS, Jonathan |
| Pharmaceutical formulations of glutenase enzymes are provided. The enzymes find particular use in the treatment of a Celiac or dermatitis herpetiformis patient. | ||||||
| 112 | Method and kit for confirming in vitro diagnosis of coeliac disease | US898865 | 1997-07-23 | US5817523A | 1998-10-06 | Antonio Picarelli |
| In order to diagnose the coeliac disease antiendomysial antibodies are detected through immunofluorescence techniques in culture media in which bioptic fragments of the human enteral mucosa are kept alive. The cultures of the enteral mucosa take place by dipping the bioptic fragment into nutrient liquids with or without the presence of low concentrations of peptic-tryptic digest of gliadin. The peptide fragment of gliadin containing a definite aminoacid sequence capable of production of antiendomysial antibodies to a greater extent than the PT digest, even in very little concentration, is also identified. | ||||||
| 113 | METHODS AND APPARATUS FOR DETECTION OF GLUTEN SENSITIVITY, AND ITS DIFFERENTIATION FROM CELIAC DISEASE | EP12737185 | 2012-01-19 | EP2666017A4 | 2014-11-19 | VOJDANI ARISTO |
| Antibodies are used as biomarkers to assist in distinguishing gluten immune reactivity and sensitivity, silent celiac disease, Crohn's disease and other gut-related pathologies from classical celiac disease. In one class of embodiments, sera, saliva or other samples from a human or other animal are tested for antibodies to (a) a wheat antigen; (b) a gliadin antigen; and (c) one or more of a wheat germ agglutinin, a gluteomorphin, a glutenin, a deamidated glutenin, a prodynorphin, and a dynorphin. Test results are considered particularly interesting where the wheat antigen and the gliadin antigen are both selected from the group consisting of an α-gliadin-33-mer, an α-gliadin-17-mer, a γ-gliadin-15-mer, an ω-gliadin-17-mer, and a glutenin-21-mer. Test plates and kits can advantageously test for antigens to at least three, five, seven or all of α-gliadin, γ-gliadin, ω-gliadin, glutenin, wheat germ agglutinin, gluteomorphin, prodynorphins, transglutaminase-2, transglutaminase-3, transglutaminase-6, and gliadin-bound transglutaminase. | ||||||
| 114 | METHODS AND APPARATUS FOR DETECTION OF GLUTEN SENSITIVITY, AND ITS DIFFERENTIATION FROM CELIAC DISEASE | EP12737185.4 | 2012-01-19 | EP2666017A2 | 2013-11-27 | VOJDANI, Aristo |
| Antibodies are used as biomarkers to assist in distinguishing gluten immune reactivity and sensitivity, silent celiac disease, Crohn's disease and other gut-related pathologies from classical celiac disease. In one class of embodiments, sera, saliva or other samples from a human or other animal are tested for antibodies to (a) a wheat antigen; (b) a gliadin antigen; and (c) one or more of a wheat germ agglutinin, a gluteomorphin, a glutenin, a deamidated glutenin, a prodynorphin, and a dynorphin. Test results are considered particularly interesting where the wheat antigen and the gliadin antigen are both selected from the group consisting of an α-gliadin-33-mer, an α-gliadin- 17-mer, a γ-gliadin-15-mer, an ω-gliadin-17-mer, and a glutenin-21 -mer. Test plates and kits can advantageously test for antigens to at least three, five, seven or all of α-gliadin, γ- gliadin, ω-gliadin, glutenin, wheat germ agglutinin, gluteomorphin, prodynorphins, transglutaminase-2, transglutaminase-3, transglutaminase-6, and gliadin-bound transglutaminase. | ||||||
| 115 | COMPOUNDS FOR THE SELECTIVE TREATMENT OF THE INTESTINAL IMMUNO-INFLAMMATORY COMPONENT OF THE CELIAC DISEASE | EP08863709.5 | 2008-12-23 | EP2222291A2 | 2010-09-01 | BARONI, Sergio; BELLINVIA, Salvatore |
| In one aspect, the present invention relates to amino-salicylic - aminophenylpropionic compounds for the use in the treatment of the inflammatory component of the celiac disease. These compounds act by blocking the cytokines released in the celiac disease and are specifically useful in the treatment of cases refractory to the diet, in dietary errors and in the reduction of the celiac disease remission time. | ||||||
| 116 | IMMUNOLOGICAL ASSAY FOR DETECTION OF ANTIBODIES IN CELIAC DISEASE | EP00982660.3 | 2000-10-17 | EP1222210A1 | 2002-07-17 | RAJADHYAKSHA, Manoj; KUMAR, Vijay |
| The present invention discloses a method for the detection of antibodies in celiac disease. The method comprises detecting antibodies in serum, to a combination of transglutaminase and a substrate therefor. | ||||||
| 117 | Prolyl endopeptidease (PEP) and glutamine endoprotease for the treatment of Celiac Sprue | EP05714080.8 | 2005-02-23 | EP1740197B1 | 2013-10-16 | SHAN, Lu; BETHUNE, Michael; KHOSLA, Chaitan; GASS, Jonathan |
| 118 | COMBINATION ENZYME THERAPY FOR GASTRIC DIGESTION OF DIETARY GLUTEN IN CELIAC SPRUE PATIENTS | EP08859388 | 2008-12-08 | EP2229404A4 | 2011-03-09 | KHOSLA CHAITAN; EHREN JENNIFER |
| 119 | COMBINATION ENZYME THERAPY FOR GASTRIC DIGESTION OF DIETARY GLUTEN IN CELIAC SPRUE PATIENTS | EP08859388.4 | 2008-12-08 | EP2229404A1 | 2010-09-22 | KHOSLA, Chaitan; EHREN, Jennifer |
| Combination enzyme products and methods of use thereof are provided. Aspergillopepsin I is combined with a protease enzyme that provides for an additive or synergistic effect in the digestion of toxic gluten oligopeptides. The enzyme products are useful in the treatment of Celiac Sprue patients, particularly for patients who continue to exhibit signs or symptoms of active disease despite following a gluten-free diet. | ||||||
| 120 | IMMUNOLOGICAL ASSAY FOR DETECTION OF ANTIBODIES IN CELIAC DISEASE | EP00982660 | 2000-10-17 | EP1222210A4 | 2004-12-08 | RAJADHYAKSHA MANOJ; KUMAR VIJAY |
| The present invention discloses a method for the detection of antibodies in celiac disease. The method comprises detecting antibodies in serum, to a combination of transglutaminase and a substrate therefor. | ||||||
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