Obtention of an alkaloid from nuphar luteum

申请号 US17647762 申请日 1962-02-16 公开(公告)号 US3147246A 公开(公告)日 1964-09-01
申请人 VNII LEKARSTVENNY I AROMATICHE; 发明人 ADOLFOVNA ALOSHKINA JANINA; ALEXANDROVNA VICHKANOVA SERAFI; NICOLAEVNA ILJINSKAJA TAMARA; ABRAMOVNA ROOBINCHIK MIRA;
摘要
权利要求
1. A METHOD OF OBTAINING AN ALKALOID PREPARATION WHICH COMPRISES EXTRACTING, IN THE PRESENCE OF AMMONIUM HYDROXIDE, A MIXTURE OF ALKALOIDS FROM THE RHIZOMES OF NUPHAR LUTEUM BY MEANS OF DICHLOROETHANE, TREATING SAID EXTRACTION MIXTURE WITH 10% SULFURIC ACID, ALKALIZING SAID ACIDULATED MIXTURE WITTH AMMONIA, EXTRACTING SAID ALKALOIDS FROM SAID ALKALIZED MIXTURE BY MEANS OF CHLOROFORM, VAPORIZING SAID CHLOROFORM FROM SAID EXTRACTION, DISICCATING THE RESIDUAL MIXTURE OF ALKALOIDS REMAINING AFTER SAID VAPORIZATION, CRUSHING SAID RESIDUAL MATERIAL, DISSOLVING SAID CRUSHED RESIDUAL MATERIAL IN ETHANOL, ADDING METHENE-BIS-SALICYLIC ACID TO PRECIPITATE SAID BIOLOGICALLY ACTIVE ALKALOID AS ITS CORRESPONDING SALT, FILTERING SAID ALKALOID SALT FROM THE SUPERNATANT SOLUTION, WASHING SAID PRECIPITATE WITH ETHANOL, SUSPENDING SAID WASHED PRECIPITATE IN A 10% AMMONIA SOLUTION, EXTRACTING SAID BIOLOGICALLY ACTIVE ALKALOID SALT FROM SAID AMMONIATED SUSPENSION BY MEANS OF ETHYL ETHER, DRYING SAID ETHYL ETHER SOLUTION OVER ROASTED POTASH, FILTERING SAID ETHYL ETHER SOLUTION, PASSING SAID DRIED ETHER SOLUTION THROUGH AN ALUMINUM OXIDE COLUMN, BUBBLING DRY GASEOUS HYDROGEN CHLORIDE THROUGH THE ELUATE FROM SAID ALUMINUM OXIDE COLUMN, COLLECTING THE HYDROCHLORIDE OF SAID BIOLOGICALLY ACTIVE ALKALOID SALT ON A FILTER, WASHING SAID HYDROCHLORIDE ALKALOID SALT WITH ETHYL ETHER AND THEREATER DESICCATING SAID HYDROCHLORIDE ALKALOID SALT.
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