This invention relates to substituted-1,3,4-benzotriazepines of the formula wherein X and Y are each independently hydrogen, lower alkyl, halogen, lower alkoxy, nitro and hydroxyl; R₁ and R₃ are each independently hydrogen or alkyl; R₂ is hydrogen, lower alkyl, cycloalkyl lower alkyl, phenyl, aryl lower alkyl, hydroxyl and sulfhydryl; m and n are each independently integers of 0 or 1 and when m is 0, n is 1 and vice-versa; and p and q are independently integers of 1 or 2. Also included in the invention are the substituted-1,3,4-benzotriazepine derivatives of tautomeric form when the substituent for R, and or R₃ in the above formula is hvdrogen.

The invention relates further to a process for the preparation of the mentioned compounds and their use as antihypertensive agents.

There is disclosed a light-sensitive silver halide photographic material containing a compound represented by the formula (1):

Formula (I): wherein G, R₁, R₂ and X have the same meanings as defined in the specification.

The 1-naphthol coupler which is contained in the light-sensitive silver halide photographic material is high in reactivity with an oxidized product of a color forming developing agent and can efficiently impart imagewise photographic effects to light-sensitive silver halide photographic materials.

Die Erfindung betrifft Thromboxan-Synthetase hemmende Verbindungen der Formel worin R₁ Wasserstoff oder Niederalkyl bedeutet, Ar für unsubstituisrtes oder durch Niederalkyl, Carboxy, Niederalkoxycarbonyl oder Carbamoyl substituiertes Pyridyl steht, R₂ und R₃ unabhängig voneinander Wasserstoff, Niederalkyl, Halogen, Trifluormethy!, Hydroxy, Nlederalkoxy, Carboxyniederalkyl, Niederafkoxycarbonyl-niederalkyl, Carboxy, Niederalkoxycarbonyl oder Nlederalkyl-(thio, sulfinyl oder sulfonyl) bedeutet, oder R₂ und R₃ zusammen, an benachbarten Kohlenstoffatomen, für Nlederalkylendioxy stehen; A für Alkylen mit 1 bis 12 Kohlenstoffatomen, Alkenylen mit 2 bis 12 Kohlenstoffatomen, Alkynylen mit 2 bis 12 Kohlenstoffatomen, Niederalkylen-phenylen-niederafkylen, Nisderatkylen-phenylen, Phenylen-niederalkylen, Phenylen, eine direkte Bindung, Niederalkylen-(thio oder oxy)-niederalkylen, (Thio oder Oxy)-phenylen, Niederalkylen-(thio oder oxy)-phenylen, Phenylen-(thio oder oxy)-niederalkylen oder Phenylen-niederalkenylen steht, B Carboxy, Niederalkoxycarbonyl, Carbamoyl, Mono- oder Di-niederalkyl-carbamoyl, Hydroxymethyl, Hydroxycarbamoyl, 5-Tetrazolyl oder Formyl bedeutet; ihre N-Oxide; und ihre Salze, insbesondere ihre therapeutisch verwendbaren Salze. Sie können z.B. durch Ringschluß von Verbindungen der Formel erhalten werden.

Die Erfindung betrifft Propionsäureamide der Formel worin R¹, R² und R die in der Beschreibung angegebenen Bedeutungen besitzen, Verfahren zu deren Herstellung, Unkrautbekämpfungsmittel, die diese Verbindungen als Wirkstoffe enthalten, sowie die Verwendung solcher Verbindungen bzw. Mittel zur Bekämpfung von Unkräutern.

Compound of formula l, wherein

• R, and R. are each hydrogen, halogen, alkyl, alkoxy, alkylthio or trifluoromethyl,
• R₂ is hydrogen, alkyl, hydroxyalkyl or a physiologically acceptable hydrolyzable esterthereof, and
• R₃ is hydrogen, alkyl, alkenyl or benzyl, or an acid addition salt thereof, are useful as neuroleptics, anti-depressants or soporifics.

A compound of the formula or its pharmaceutically acceptable salt:

• wherein R¹ is hydrogen or acyl;
• R₂ is carboxy or protected carboxy or a group of the formula:
  • -COHN-R² wherein R²a is carboxy(lower)alkyl or protected carboxy(lower)alkyl;
• R³ is carboxy, protected carboxy, lower alkyl, hydroxyphenyl, carbamoyl ora graup oftheformula: R³a-CH-R³b wherein R³a is hydrogen, amino, protected amino or a cylamino, R³b is carboxy or protected carboxy;
• R^Pis carboxy, protected carboxy, carbamoyl, carboxy(lower)alkyl or protected carboxy(lower)alkyl; ℓ isaninteger0or2, m is an integer 0 to 3 and n is an integer 0 to 1, with certain provisions, and pharmaceutically acceptable salts thereof and process for their preparation, and also a pharmaceutical composition comprising, as an effective ingredient, the above compound in association with a pharmaceutically acceptable, substantially nontoxic carrier or excipient.

The invention relates to novel [(5,6,9a-substituted-3-oxo-1,2,9,9a-tetrahydro-3H-fluoren-7-yl)-oxy]alkanoic and cycloalkanoic acid esters, analogs, the parent acids and their salts, and derivatives. These compounds are synthesized by methods selected from a number of synthetic routes depending on the particular structure, choice of intermediate or preferred reaction sequence. The compounds are useful in the treatment and prevention of injury to the brain and spinal chord due to accidents, ischemic stroke and hydrocephalus; compositions for such uses are also disclosed.

N-(a -Chlorpropionyl)-1,2,3,4 -tetrahydro-chinaldin der Formel ein Verfahren zu dessen Herstellung sowie dessen Verwendung als Gegenmittel zum Schutz von Kulturpflanzen vor Herbizidschaden.

Herbizide Wirkstoffkombinationen auf Basis von N-(a-Chloropropionyl) -1,2,3,4-tetrahydro-chinaldin und herbizid wirksamen Thiocarbamaten bzw. Acetaniliden.

The invention provides novel 1- or 2-adamantylmethyl hydrazines of the general formulaA

In this formula Ad is 1- or 2-adamantyl, R₁ and R₂ are the same or different and are each hydrogen or a lower unsubstituted or substituted alkyl group of 1-4 carbon atoms; R, and R₄ are the same or different and are each hydrogen, an unsubstituted or substituted radical being a lower alkyl group of 1-4 carbon atoms, a lower alkanoic acid radical of 2-4 carbon atoms or a lower alkyl ester thereof, adamantyl, aryl, aralkyl in which the alkyl moiety has 1-4 carbon atoms or an unsubstituted or substituted heterocyclic radical of aromatic character; or R₃ and R₄ together with the nitrogen atom to which they are attached form a cyclic radical of non-aromatic character.

The invention further provides pharmaceutically acceptable acid addition salts of the above compounds.

Several methods of preparation of the new compounds are described.

The novel compounds according to the invention possess valuable antifungal (human and plant), antiviral, antiprotozoal and antimicrobial properties.