Disclosed are novel compounds of the formula: wherein:

X=-NR₅R₆, or -OR₇;

R₁ and R₂ are independently hydrogen, substituted or unsubstituted alkyl, haloalkyl, hydroxyalkyl, alkoxyalkyl, alkylaminoalkyl or arylalkyl having up to 18 carbons; cyclo­alkyl; phenyl or naphthyl; alkylphenyl, cyanophenyl, halophenyl or alkoxyphenyl substituents.

R₃ is hydrogen, benzyl, alkoxybenzyl, halobenzyl or alkylbenzyl, provided that if neither R₁ nor R₂ is hydrogen, then R₃ is hydrogen.

R₄ is a divalent aromatic group which is substitu­ted or unsubstituted.

R₅, R₆, and R₇ are independently hydrogen, alkyl, hydroxyalkyl, haloalkyl, alkoxyalkyl, alkylaminoalkyl, acyl­aminoalkyl, aminoalkyl or phenylalkyl having up to 12 carbons; a cycloalkyl substituent; phenyl or naphthyl; an alkylphenyl, cyanophenyl, halophenyl or alkoxyphenyl substituent.

Furthermore, either R₁ and R₃ or R₁ and R₂ can be linked to form a heterocyclic ring system containing 3-10 atoms.

Additionally, R₅ and R₆ can be linked to form a heterocyclic ring system containing 3-10 atoms.

Y is an oxygen or sulfur atom. If Y is sulfur then n=1, if Y is oxygen then n=0 or 1.

These compounds are useful as high-quality dot promoting agents in negative-working photographic systems.

Disclosed as well are radiation-sensitive compositions and elements containing such dot promoting agents in combination with silver halide grains. These exposed compositions and elements when processed in a developer containing a dihydroxybenzene developing agent, a substituted benzotriazole, a sulfite preservative and an amine compound provide a method for the production of halftone dots possessing high image quality.

A silver halide photographic light-sensitive material comprising a support and at least one silver halide emulsion layer wherein the silver halide photographic light-sensitive material contains at least one compound represented by the following general formula (I): wherein COUP represents a coupler residue capable of undergoing a coupling reaction with an oxidation product of an aromatic primary amine developing agent; TIME represents a timing group which is released from COUP the coupling reaction and subsequently releases represents a group capable of being released from COUP by the coupling reaction when n is 0, or a group capable of being released from TIME after TIME which has been released from COUP when n is 1, AD being adsorptive to silver halide particles; R represents an alkyl group, an aryl group or a heterocyclic group; R' and R", which may be the same or different, each represents a hydrogen atom or a substitutent; and -NHNHCOR may be directly connected to AD when AD is combined with the benzene ring to form a condensed ring system.

The'silver halide photographic light-sensitive material containing the compound represented by general formula (I) is improved in stability during storage and has a high sensitivity.

Verfahren zur Herstellung von substituierten Phenylhydrazinen der Formel (I) in welcher

• R' und R² für Wasserstoff oder Chlor stehen,
• R³ für Halogenalkyl steht,
• X für Sauerstoff, Schwefel, Sulfinyl oder Sulfonyl steht und
• n für eine Zahl 0 oder 1 steht, dadurch gekennzeichnet, daß man substituierte Chlorbenzole der Formel (II) in welcher
• R¹, R², R³, X und n die oben angegebene Bedeutung haben mit Hydrazin oder Hydrazinhydrat, gegebenenfalls in Gegenwart eines Verdünnungsmittels und gegebenenfalls bei erhöhtem Druck bei Temperaturen zwischen 60 und 160°C umsetzt, ihre Verwendung als Zwischenprodukte zur Herstellung von Herbiziden.

Novel phenylserine derivatives of the formula: and pharmaceutically acceptable acid addition salts thereof. pharmaceutical compositions, and a process for preparing the compounds. Said phenylserine derivatives and pharmaceutically acceptable acid addition salts show activities of inhibiting the biosynthesis of leucotrienes and/or antagonistic activity against SRS-A and hence are useful for prophyla xis and treatment of various allergic diseases (e g bronchial asthma. allergic nasitis, urticaria), ischemic heart disease. ischemic encephalopathy, inflammation or the like.

A compound of the formula: wherein R is a hydrogen atom, a C₁-C₄ alkoxy group, a C₁-C₄ alkenyloxy group, a C₃-C₄ alkynyloxy group, a C₁-C₄ alkylthio group, a dichlorocyclopropylmethoxy group or a methyldichlorocyclopropylmethoxy group, X is a chlorine atom or a bromine atom and Y is a hydrogen atom, a fluorine atom or a chlorine atom, which is useful as a herbicide.

Novel fluorophenoxyphenoxypropionates and derivatives thereof and compounds related thereto possess herbicidal activity selectively in the presence of broadleaf crops. Preemergent and postemergent applications are contemplated.

The compounds are of the formula wherein

• X represents -F, -Cl, -Br, -I, -CF₃, -OCF₃, -CF₂CI, -CF₂H or-CF₂CCl₂H; and
• Z represents an organic moiety, the moiety containing N, O or S atoms, a metallic cation, an ammonium cation or an organic amine cation and is, or can be hydrolyzed and/or oxidized in plants or soil to, a carboxyl moiety that is in undissociated and/or dissociated form.
• Preferably Z ist or an agriculturally acceptable salt, amide or ester thereof.
• Also provided are novel intermediates of the formula wherein
• Y is OH, NH₂ or N₂⊕ BF₄⊖, as well as herbicidal compositions and a method of controlling weeds by applying to them one or more of the active compounds of the invention.

Die Erfindung betrifft neue substituierte 5-Acylamino-1-phenylpyrazole der allgemeinen Formel (I) in welcher

• R¹ für Cyano, Alkoxycarbonyl, Alkenyloxycarbonyl, Alkinyloxycarbonyl, Aminocarbonyl, Alkylaminocarbonyl, Alkenylaminocarbonyl oder Alkinylaminocarbonyl steht,
• R² für Wasserstoff, Alkyl, Alkenyl, Alkinyl, gegebenenfalls substituiertes Cycloalkyl, Alkoxyalkyl, Alkylthioalkyl, Halogenalkyl oder für gegebenenfalls substituiertes Aryl steht und
• _R³, _R⁴, _R⁵, _R⁶ und R⁷, welche gleich oder verschieden sind, für Wasserstoff, Halogen, Cyano, Nitro, Alkyl, Alkoxy, Alkylsulfonyl, Alkoxycarbonyl oder für einen Rest-(X)_n-R⁸ stehen, wobei X für Sauerstoff, Schwefel, Sulfinyl oder Sulfonyl steht, n für 0 oder 1 steht und R⁸ für Halogenalkyl steht,
• mit der Maßgabe, daß mindestens einer der Reste R³, R4, R⁵, R⁶ oder R⁷ für einen Rest -(X)_n-R⁸ steht, wobei jedoch nicht gleichzeitig R¹ für Cyano und R⁵ für Trifluormethyl stehen,
• ein Verfahren zu ihrer Herstellung und ihre Verwendung als Herbizide.

There are described compounds of formula I, in which

• Z is R₂CH (COOH) NH- or R₁SCH₂-,
• R₁is hydrogen or R₈CO-,
• R₈ is alkyl C1 to 10 or phenyl,
• R is hydrogen, alkyl C1 to 6, or alkyl C1 to 6 substituted by phenyl, -NH₂, -COOH or by alkyl C1 to 6 thio,
• R₂ is hydrogen, alkyl C1 to 10, cycloalkyl C3 to 10, phenyl, phenylalkyl C7 to 12, alkoxy C1 to 6 - alkyl C1 to 6, alkyl C1 to 6 - thioalkyl C1 to 6, phenyloxyalkyl C7 to 12 or phenylthioalkyl C7 to 12,
• R. and R₅, which may be the same or different, are each hydrogen, alkyl C1 to 10, cycloalkyl C3 to 10, phenylalkyl C7 to 12, or phenyl; the phenyl and phenylalkyl each optionally being substituted by one or more alkyl C1 to 6, alkoxy C1 to 6 or halogen groups, or
• R. and R₅ together form a - (CH₂),,- or - (CW₂)₅- chain, and
• R₆ is hydrogen, alkyl C1 to 6 or phenylalkyl C7 to 12, and pharmaceutically acceptable salts and esters thereof.

There are also described processes for making the compounds and their formulation and use as pharmaceuticals, eg. angiotensin converting enzyme inhibitors.

Die vorliegende Erfindung betrifft neue fünfgliedrige stickstoffhaltige Heterocyclen der Formel (I) in welcher R¹, R², R³, X, Y die in der Beschreibung angegebene Bedeutung besitzen.

Die Verbindungen der Formel werden erhalten, indem man Verbindungen der Formel II mit Verbindungen der Formel III umsetzt, oder indem man Verbindungen der Formel IV mit Verbindungen der Formel V umsetzt, oder indem man Verbindungen der Formel VI mit Verbindungen der Formel VII (Fortsetzung nächste Seite) umsetzt, und in Gegenwart einer Base erwärmt, oder indem man Verbindungen der Formel II mit Verbindungen der Formel IX umsetzt, oder indem man Verbindungen der Formel X mit Verbindungen der Formel XI umsetzt, wobei in den Formeln die Reste die in der Beschreibung angegebene Bedeutung besitzen. Die Verbindungen der Formel eignen sich als Schädlingsbekämpfungsmittel, insbesondere als Insektizide und Akarizide.

Chemical compounds are provided that are novel substituted benzothiopyrano[4,3,2-cd]indazoles, as well as methods for their production, pharmaceutical compositions comprising the compounds, and methods of treatment using the compounds in dosage form. Compounds of the invention have pharmacological properties and are useful antibacterial agents, antifungal agents, and antitumor agents.

A 2-substituted phenyl-4,5,6,7-tetrahydro-2H-indazole compound of the formula: wherein X is a chlorine atom or a bromine atom, Y is an oxygen atom or an imino group, Z is a chlorine atom or a methyl group and R is a C₁-C₄ alkyl group, a C₃-C₄ alkenyl group, a C₃-C₄ alkynyl group, a C₁-C₆ alkoxycarbonylmethyl group, a C₃-C₆ cycloalkoxycarbonylmethyl group or a C₁-C₄ haloalkoxycarbonylmethyl group, which is useful as a herbicide.

Substituted anthra[1,9-cd]pyrazool-6(2H)-ones have antimicrobial activity. Methods for their preparation, use and pharmaceutical compositions are disclosed. Some of the novel anthra[1,9-cd]pyrazol-6(2H)-ones have the following formula: where the radicals W, X, X', Y, Z and R are hydrogen atoms or various substituents.