| 序号 | 专利名 | 申请号 | 申请日 | 公开（公告）号 | 公开（公告）日 | 发明人 |
|---|---|---|---|---|---|---|
| 1 | Crystal structures of bacterial guanylate kinases | US11122793 | 2005-05-05 | US20060073581A1 | 2006-04-06 | Aled Edwards; Akil Dharamsi; Masoud Vedadi; Nicole Brufatto; Teresa Clarke |
| The present invention relates to novel drug targets for pathogenic bacteria. Accordingly, the invention provides purified protein comprising the amino acid sequence set forth in SEQ ID NO: 4. The invention also provides biochemical and biophysical characteristics of the polypeptides of the invention. | ||||||
| 2 | Method of killing cancer cells | US10385163 | 2003-03-10 | US20040180844A1 | 2004-09-16 | Stephen W. Fesik; Donald N. Halbert; Randy E. Metzger; Jeffrey A. McDowell; Mark E. Schurdak; Susan E. Morgan-Lappe; Aparna V. Sarthy |
| A method of killing cancer cells comprising inhibiting the function of a gene selected from the group consisting of CDK8, STK33, PRKCM, PRKACA, ACVR1B, CDK5R1, CDC42BPB, MPP6, and CDC42BPA; pharmaceutical compositions comprising an inhibitor of the same, and a method of detecting cellular hyperplasia. | ||||||
| 3 | Modulating the interaction between ZO-2/TJP2 and a Snail zinc finger transcription factor family member | US14380583 | 2013-02-28 | US09963704B2 | 2018-05-08 | Walter Hunziker; Choon Peng Goh |
| There is provided a method of identifying candidate agents capable of modulating interaction between a first polypeptide and a second polypeptide, wherein the first polypeptide is ZO-2/TJP2 or a functional variant thereof and the second polypeptide is a Snail zinc finger transcription factor family member or a functional variant thereof. | ||||||
| 4 | MODULATING THE INTERACTION BETWEEN ZO-2/TJP2 AND A SNAIL ZINC FINGER TRANSCRIPTION FACTOR FAMILY MEMBER | US14380583 | 2013-02-28 | US20150031748A1 | 2015-01-29 | Walter Hunziker; Choon Peng Goh |
| There is provided a method of identifying candidate agents capable of modulating interaction between a first polypeptide and a second polypeptide, wherein the first polypeptide is ZO-2/TJP2 or a functional variant thereof and the second polypeptide is a Snail zinc finger transcription factor family member or a functional variant thereof. | ||||||
| 5 | Novel purified polypeptides from bacteria | US10958216 | 2004-10-04 | US20050181388A1 | 2005-08-18 | Aled Edwards; Akil Dharamsi; Masoud Vedadi; Muhammad Alam; Cheryl Arrowsmith; Donald Awrey; Bryan Beattie; Kristina Buzadzija; Veronica Canadien; Megan Domagala; Simon Houston; Dhushy Kanagarajah; Qin Li; Kamran Mansoury; Merry-Lynn McDonald; Kathleen Nethery-Brokx; Ivy Ng; Hui Ouyang; Benjamin Pinder; Dawn Richards; Matthew Tai; Rosanne Thalakada; Francois Vallee; Cristina Virag |
| The present invention relates to polypeptide targets for pathogenic bacteria. The invention also provides biochemical and biophysical characteristics of those polypeptides. | ||||||
| 6 | Method of killing cancer cells | US10796177 | 2004-03-09 | US20040180848A1 | 2004-09-16 | Stephen W. Fesik; Donald N. Halbert; Randy E. Metzger; Jeffrey A. McDowell; Mark E. Schurdak; Susan E. Morgan-Lappe; Aparna V. Sarthy |
| A method of killing cancer cells comprising inhibiting the function of a gene selected from the group consisting of CDK8, STK33, PRKCM, PRKACA, ACVR1B, CDK5R1, CDC42BPB, MPP6, and CDC42BPA; pharmaceutical compositions comprising an inhibitor of the same, and a method of detecting cellular hyperplasia. | ||||||
| 7 | METHOD OF KILLING CANCER CELLS | PCT/US2004007177 | 2004-03-10 | WO2004080287A3 | 2005-03-17 | FESIK STEPHEN W; HALBERT DONALD N; METZGER RANDY E; MCDOWELL JEFFREY A; SCHURDAK MARK E; MORGAN-LAPPE SUSAN E; SARTHY APARNA V |
| A method of killing cancer cells comprising inhibiting the function of a gene selected from the group consisting of CDK8, STK33, PRKCM, PRKACA, ACVR1B, CDK5R1, CDC42BPB, MPP6, and CDC42BPA; pharmaceutical compositions comprising an inhibitor of the same, and a method of detecting cellular hyperplasia. More specifically, the inhibitors are oligonucleotides and siRNA. | ||||||
| 8 | CRYSTAL STRUCTURES OF BACTERIAL GUANYLATE KINASES | PCT/CA0301673 | 2003-11-05 | WO2004042044A3 | 2005-02-24 | EDWARDS ALED; DHARAMSI AKIL; VEDADI MASOUD; DOMAGALA MEGAN; PINDER BENJAMIN; ALAM MUHAMMAD ZAHOOR; KIMBER MATTHEW; CLARKE TERESA; LAM ROBERT |
| The present invention relates to novel drug targets for pathogenic bacteria. Accordingly, the invention provides purified protein comprising the amino acid sequence set forth in SEQ ID NO: 4. The invention also provides biochemical and biophysical characteristics of the polypeptides of the invention. | ||||||
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