最新美国发明专利第2019-01-29期 - 专利汇|PatentHub专利检索|专利查询网|发明专利查询分析

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US10190104B2	Isoform of anaplastic lymphoma kinase and its uses The present invention relates to a Truncated isoform of Anaplastic Lymphoma Kinase (“TALK”). Expression of this isoform is associated with malignancy and with responsiveness to ALK inhibitors. Detection of the isoform may be used in diagnostic and therapeutic methods. Because it arises as a result of variant transcription rather than genetic rearrangement, its presence would be undetected by genomic testing.
US10190103B2	Polypeptides having glucuronyl esterase activity and polynucleotides encoding same The present invention relates to isolated polypeptides having glucuronyl esterase activity, catalytic domains and polynucleotides encoding the polypeptides or catalytic domains. The invention also relates to nucleic acid constructs, vectors, and host cells comprising the polynucleotides as well as methods of producing and using the polypeptides or catalytic domains.
US10190097B2	Method and composition for inducing human pluripotent stem cells The present invention provides a method of forming a fibromodulin (FMOD) reprogrammed (FReP) cell. The method comprises steps of treating a human cell with a cell culture medium comprising fibromodulin (FMOD) for a period ranging from a day to a month, and changing the cell culture medium regularly until a FMOD reprogrammed (FreP) cell forms; wherein the FreP cell expresses NANOG and does not form teratoma, and wherein the human cell is a fibroblastic cell.
US10190095B2	Myelination of congenitally dysmyelinated forebrains using oligodendrocyte progenitor cells One form of the present invention is directed to a method of remyelinating demyelinated axons by treating the demyelinated axons with oligodendrocyte progenitor cells under conditions which permit remyelination of the axons. Another aspect of the present invention relates to a method of treating a subject having a condition mediated by a loss of myelin or a loss of oligodendrocytes by administering to the subject oligodendrocyte progenitor cells under conditions effective to treat the condition mediated by a loss of myelin or a loss of oligodendrocytes. A further aspect of the present invention relates to an in vitro method of identifying and separating oligodendrocyte progenitor cells from a mixed population containing other mammalian brain or spinal cord cell types.
US10190093B2	Artificial oocyte activation The present invention provides novel methods for improving the efficiency of artificial activation of unfertilized mammalian oocytes by reducing the intracellular concentration of Zn2+ in the oocyte. The methods of the invention may additionally comprise a preceding step of increasing the intracellular concentration of Ca2+ in the oocyte prior to reduction of the intracellular Zn2+ concentration. The invention further provides unfertilized oocytes activated by the disclosed methods and viable mammalian animals produced from unfertilized oocytes activated by the disclosed methods.
US10190090B2	Methods and systems for forming stable particles from suspended solids produced by ethanol fermentation Methods and systems for forming stable particles from suspended solids produced by ethanol fermentation are disclosed. The methods include providing a fraction from ethanol fermentation containing solids and suspended solids. The pH of the fraction is adjusted, if necessary. A reducing agent is added. A high molecular weight anionic polymer is added to form stable particles of solids and suspended solids. Lastly, the stable particles are free drained to separate them from a treated liquid portion. The treated liquid portion is added as backset to the fermentation process while the recovered solids are further processed into useful products.
US10190086B2	Methods of pitching yeast for fermentation, and related methods of fermentation and systems The present invention relates to methods and systems of pitching yeast to fermentation reactors. More particularly, the present invention involves pitching yeast from one fermentation tank to at least one additional fermentation tank. Advantageously, yeast can be continuously pitched from fermentor to fermentor for as long as practically desirable.
US10190084B2	Method of culturing eukaryotic cells An apparatus and method to maintain pH within a range conducive for cell growth in a bicarbonate-containing cell culture system without the addition of base. The method relies on the gas transfer characteristics of the bioreactor system to modulate the CO2 transfer to and from the cell culture such that the pH of the cell culture can be maintained within a desired range.
US10190081B2	Volatile organic compound recovery system and method The present invention provides for passive V0C recovery in the fermentation process that does not affect or minimally affects the conditions within the fermentor vessel and does not affect or minimally affects the conditions within the headspace of the fermentor vessel itself while using the production of CO2 emitted during the fermenting process as the source of driving energy to move a portion of the gaseous/vaporous material in the headspace of the fermentor through an appropriately sized conduit to a chilled surface condensing device to condense the V0Cs (principally ethanol) for recovery and to exhaust the CO2 to the atmosphere or to recover the CO2 for other uses. The conduit from the headspace of the fermentor to the condenser is sized to provide a flow restriction in a selected range such that the headspace equilibria are not affected while allowing a portion of the gaseous/vaporous material in the headspace to move through the conduit in response to the generation of the CO2 during the fermentation process.
US10190080B2	Method for cleaning systems A method is provided for cleaning a system by conducting continuously through the system a cleaning composition including at least one oxidizing agent and an indicator for detecting the cleanliness of the system by observation of a color change of the indicator. Color values are determined at one or more points and compared with a setpoint value. Color values F are determined at fixed time intervals after exit of the composition from the system; differences ΔF are formed from two color successive values; color values are determined before commissioning of the clean system until the difference ΔF=0, after which the color value measured last is defined as an inherent system value FA and a maximum tolerable deviation from this value is fixed as a setpoint value ΔFA for cleaning; and cleaning of the system is carried out after operation of the system until a difference of ≤ΔFA is measured.
US10190075B2	Enrichment of palmitoleic acid and palmitoleic acid derivatives by dry and solvent-aided winterization The present invention provides a fatty acid mixture enriched with palmitoleic acid and palmitoleic acid derivatives relative to the starting lipid mixture; fractionations procedure describe herein are winterization methods. The invention provides methods of dry winterization and solvent-aided winterization alone and in combination. In some embodiments, the palmitoleic acid and palmitoleic acid derivative enriched mixture described herein contains less than 1% of palmitic acid and palmitic acid derivative. The invention also provides palmitoleic derivatives of use as dietary supplements.
US10190072B2	Method for improving engine fuel efficiency A method for improving fuel efficiency and reducing frictional properties while maintaining or improving deposit control, in an engine lubricated with a lubricating oil. The lubricating engine oil has a composition including from 75 to 95 wt % of lubricating oil base stock selected from the group consisting of a Group I base stock, a Group II base stock, a Group III base stock, a Group IV base stock, a Group V base stock and combinations thereof; a friction modifier mixture comprising a polymeric ethoxylated fatty acid ester having a molecular weight of greater than or equal to 2000 at from 0.1 to 1.0 wt. % and an organic molybdenum containing friction modifier contributing from 80 to 500 ppm of elemental molybdenum, and an overbased calcium salicylate detergent contributing from 200 to 2000 ppm of elemental calcium; and one or more other lubricating oil additives. The lubricating engine oils are useful in internal combustion engines including direct injection, gasoline and diesel engines.
US10190070B2	Multiple-function dispersant graft polymer A grafted polymer, either polyolefin or polyester, containing monomers associated with sludge and varnish control as well as monomers associated with soot handling to provide a graft polymer exhibiting multiple performance attributes. Also described are methods for manufacturing these novel multiple-function graft polymers via solution and melt processes. Lubricating oil compositions containing these novel multiple-function polymers as an additive that display performance characteristics directed to good soot handling and sludge and varnish control as well as control of viscosity increase are described.
US10190064B2	Integrated process for simultaneous removal and value addition to the sulfur and aromatics compounds of gas oil An integrated process for simultaneous removal and value addition to sulfur and aromatics compounds of gas oil is provided. Process includes the segregation of refractive sulfur and aromatics compounds of gas oil in heavy fraction of gas oil using distillation processing of heavy fraction of gas oil in continuous solvent extraction zone, processing of lighter fraction of gas oil and raffinate of heavy fraction of gas oil in hydrotreating reaction zone operating under mild conditions of temperature and pressure for producing the gas oil with reduced sulfur and aromatic compounds and contact of extract phase generated during continuous extraction with water in mixer settler for generating the pseudo raffinate which can be used as suitable feed to hydrocracker to generate sulfur lean gas oil.
US10190063B2	Production of oilfield hydrocarbons A process (20) to produce olefinic products suitable for use as or conversion to oilfield hydrocarbons includes separating (42) an olefins-containing Fischer-Tropsch condensate (64) into a light fraction (68), an intermediate fraction (82) and a heavy fraction (94), oligomerizing (44) at least a portion of the light fraction (68) to produce a first olefinic product (72) which includes branched internal olefins, and carrying out either one or both of the steps of (i) dehydrogenating (50) at least a portion of the intermediate fraction (82) to produce an intermediate product (84) which includes internal olefins and alpha-olefins, and synthesizing (52) higher olefins from the intermediate product which includes internal olefins and alpha-olefins to produce a second olefinic product (86), and (ii) dimerizing (52) at least a portion of the intermediate fraction to produce a second olefinic product (86). At least a portion of the heavy fraction (94) is dehydrogenated (58) to produce a third olefinic product (96) which includes internal olefins. Also provided is a process (30) to produce paraffinic products suitable for use as or conversion to oilfield hydrocarbons which includes separating (110) a Fischer-Tropsch wax (124) into at least a lighter fraction (126, 128) and a heavier fraction (130), hydrocracking (120) the heavier fraction (130) to provide a cracked intermediate (144), and separating (122) the cracked intermediate (144) into at least a naphtha fraction (148), a heavier than naphtha paraffinic distillate fraction (150) suitable for use as or conversion to oilfield hydrocarbons, and a bottoms fraction (152) which is heavier than the paraffinic distillate fraction (150).
US10190060B2	Process for increasing process furnaces energy efficiency A process for increasing furnace energy efficiency through gas turbine integration by using turbine exhaust gas, wherein a hydrocarbon feed is heated in a furnace.
US10190059B2	Process for the hydrotreatment of renewable materials, with an optimized gas recycle A process for the hydrotreatment of a feed obtained from renewable sources in which the total stream of feed F is divided into a number of different part-streams of feed F1 to Fn equal to the number of catalytic zones n, where n is 1 to 10. The mass flow rate of hydrogen sent to the first catalytic zone represents more than 80% by weight of the total mass flow rate of hydrogen used. The effluent from the reactor outlet undergoes at least one separation step. A portion of the liquid fraction is recycled to the catalytic zones in a manner such that the local recycle ratio for each of the beds is 2 or less, and the local dilution ratio over each of the beds is less than 4.
US10190058B2	High-yield production of fuels and petro- and oleo-chemical precursors from vegetable oils and other liquid feedstocks in a continuous-flow pyrolysis reactor with or without catalysts Systems, methods, and materials for pyrolyzing vegetable oil feedstocks to obtain high yields of various products are described.
US10190057B2	Fischer-tropsch synthesis A method (10) of synthesizing Fischer-Tropsch products (20) includes feeding a synthesis gas (30) to a moving-bed Fischer-Tropsch synthesis reactor (16) containing a Fischer-Tropsch catalyst in a moving catalyst bed and catalytically converting at least a portion of the synthesis gas (30) in the moving catalyst bed to Fischer-Tropsch products (20). The Fischer-Tropsch products (20) are removed from the moving-bed Fischer-Tropsch synthesis reactor (16). The method (10) further includes, while the moving-bed Fisher-Tropsch synthesis reactor (16) is on-line, withdrawing a portion (50) of the Fischer-Tropsch catalyst from the moving-bed Fischer-Tropsch synthesis reactor (16), adding a reactivated Fischer-Tropsch catalyst (57, 58) to the moving-bed Fischer-Tropsch synthesis reactor (16), and adding a fresh Fischer-Tropsch catalyst (60,58), in addition to the reactivated catalyst (57,58), to the moving-bed Fischer-Tropsch synthesis reactor (16).
US10190056B2	Conversion of solid biomass into a liquid hydrocarbon material The present invention provides a process for producing liquid hydrocarbon products from a solid biomass feedstock, said process comprising the steps of: a) providing in a first hydropyrolysis reactor vessel a first hydropyrolysis catalyst composition; b) contacting the solid biomass feedstock with said first hydropyrolysis catalyst composition and molecular hydrogen in said first hydropyrolysis reactor vessel to produce a product stream comprising partially deoxygenated hydropyrolysis product, H2O, H2, CO2, CO, C1-C3 gases, char and catalyst fines; c) removing said char and catalyst fines from said product stream; d) hydroconverting said partially deoxygenated hydropyrolysis product in a hydroconversion reactor vessel in the presence of one or more hydroconversion catalyst and of the H2O, CO2, CO, H2, and C1-C3 gas generated in step a), to produce a vapor phase product comprising substantially fully deoxygenated hydrocarbon product, H2O, CO, CO2, and C1-C3 gases.
US10190052B2	Device and method for regulating and controlling the gas pressure A device and a method are provided for regulating and controlling individual gas pressure of individual ovens of a coke oven battery, in the case of which a rising-pipe bend projects, preferably from above, into a collecting main. The lower end thereof is associated with an immersion pipe via a water labyrinth seal. The immersion pipe is supported such that it is vertically adjustable by means of an actuator, and an immersion cup is located preferably below the immersion pipe. The rising-pipe bend has arranged therein a sleeve, the lower end of which is connected via at least one conduit to the water labyrinth seal. A water supply for feeding the water labyrinth seal and the actuator are provided at the top, outside the rising-pipe bend. Regulation of the gas pressure is accomplished by different immersion depths of the immersion pipe and the constant water level in the immersion cup.
US10190051B2	Emulsification of hydrophobic organophosphorous compounds An emulsion includes at least one polymeric surfactant, water and at least one organophosphorous compound. The emulsion may include from about 1% to about 40% of the polymeric surfactant and from about 40% to about 80% of the organophosphorous compound. The emulsion may further include at least one salt or additional surfactant. The at least one polymeric surfactant may include silicone-based surfactants, polyoxypropylene-based surfactants, graft copolymers of polysaccharides, and combinations thereof. The at least one polymeric surfactant may account for about 25% to about 100% by weight of the surfactant content in the emulsion and the at least one secondary surfactant, if present, may account for up to about 75% by weight of the surfactant content in the emulsion. The emulsion may have an average dispersed phase drop size of less than about 5 micron, or less than about 1 micron, after 6 months.
US10190050B2	Liquid crystal composition, liquid crystal display device including the same, and method of manufacturing liquid crystal display device A liquid crystal composition including: a liquid crystal compound and a liquid crystal aligning agent including at least one compound represented by Formula 1: wherein in the Formula 1, X—, -L1-, -L2-, -L3-, —C—, —R—, —Y, n1, n2, and m are the same as defined in the specification.
US10190045B2	Nano-composite structure and processes making of A nano-composite structure comprises of an amorphous matrix with embedded nano-crystallites. The nano-crystallites are precipitated from the amorphous matrix via heat treatment of a solution mixture of metal salts or metalorganic compounds to an appropriate temperature range and with a suitable duration, or heating of a mixture of non-crystalline compounds. The nano-crystallites are self-assembled in the amorphous matrix without forming agglomerates or distinguished grain boundaries. The nano-composite structure can be used for transparent display, transparent optical ceramics, protection armor, nuclear protection, pulsed power, high voltage electronics, high energy storage system and high power microwave systems.
US10190034B2	Non-reducing stabilization complexant for acidizing compositions and associated methods Methods for reducing viscosifying tendencies of crude oil in subterranean formations using solid acid chelating agents are described. The methods include combining a solid acid chelating agent and an aqueous acid solution to form a treatment fluid, and introducing the treatment fluid into the subterranean formation. The solid acid chelating agent includes at least one aminopolycarboxylic acid functional group and at least one phosphonic acid functional group.
US10190033B2	Salt-free fluorous-invert emulsion fluid Disclosed are compositions, methods, and systems of treating a well. A method may comprise providing a treatment fluid comprising a fluorous oil external phase, a salt-free non-chloride containing internal phase, and a fluorous-based surfactant; and introducing the treatment fluid into a wellbore. A treatment fluid composition may comprise a fluorous oil external phase, a salt-free non-chloride containing internal phase, and a fluorous-based surfactant.
US10190026B2	Wood adhesive A wood adhesive is provided. The wood adhesive includes a first agent and a second agent. The first agent includes a sodium carboxymethyl cellulose and a styrene-butadiene rubber polymer. The sodium carboxymethyl cellulose has a molecular weight between 15,000 and 500,000 and a degree of substitution of from 0.4 to 2.00 of the sodium salt. The second agent includes a polymeric quaternary amine.
US10190024B2	Polishing composition Provided is a polishing composition capable of keeping a good polishing removal rate stably. The polishing composition includes silica particles as abrasives and a basic compound as a polishing removal accelerator. The silica particles have a density of silanol groups that is 1.5 to 6.0 pieces/nm2. The polishing composition has an adsorption ratio parameter A that is 1.2 or less, the adsorption ratio parameter representing concentration dependency of an amount of adsorption of the basic compound to the silica particles as the ratio of high-concentration adsorption amount/low-concentration adsorption amount.
US10190019B2	Multistage polymers and compositions thereof Provided are multistage polymers that comprise (i) a first stage comprising a first copolymer having a first theoretical Tg, the first copolymer being derived from a soft ethylenically-unsaturated monomer, a phosphorus-containing monomer, and an acetoacetoxy monomer; and (ii) a second stage comprising a second polymer having a second theoretical Tg, the second polymer being derived from one or more hard ethylenically-unsaturated monomers. The multistage polymers can be in the form of multilayer particles that comprise (i) a first layer comprising the first copolymer; and (ii) a second layer surrounding at least a portion of the first layer comprising the second polymer. Also provided are aqueous compositions including one or more of the multistage polymers (or multilayer particles) described herein, as well as methods for making the multistage polymers (or multilayer particles) described herein.
US10190017B2	Protective film-forming film and method of manufacturing semiconductor chip with protective film A protective film-forming film is provided for forming a protective film which protects a metal film provided on a back surface of a semiconductor chip and is not likely to peel off from the metal film even after undergoing a history of temperature changes. This protective film-forming film is formed of a protective film-forming composition to which a coupling agent having a thiol group or a protected thiol group is added.
US10190016B2	Two-component paint composition and multilayer coating formation method using this [Purpose] Among two-component top coat paints for the automobile coatings field, wherein the base resin paint is circulated from a main tank with a pump upstream of the coating gun, and mixing and coating are effected using a curing agent supplied from a nitrogen-sealed tank and a two-component mixing device, to provide a paint composition with which problems such as thickening and gelling of the circulating base resin paint do not occur, coating is possible with a stabilized constant coating viscosity, and with which the paint film after stoving exhibits excellent Scratch resistance, stain resistance, acid resistance and gasoline resistance, and a multilayer coating formation method using this. [Solution] The present invention provides a two-component paint composition which is applied directly after mixing a base resin and a curing agent, wherein the base resin (A) contains a hydroxy group-containing acrylic resin (A-1) and a curing catalyst (A-2) as essential components, the curing agent (B) contains an isocyanate Compound (B-1) and an alkoxysilyl group-containing copolymer (B-2) as essential components, the aforesaid hydroxy group-containing acrylic resin (A-1) has a hydroxyl value of 80 to 180 mg KOH/g, a glass transition temperature of −40 to 40° C., and a weight average molecular weight of 2,000 to 20,000 g/mol, the aforesaid alkoxysilyl group-containing copolymer (B-2) is a copolymer obtained by copolymerizing 30 to 80 parts by weight of a vinylic monomer containing alkoxysilyl groups and 20 to 70 parts by weight of other copolymerizable monomers, its weight average molecular weight is 2,000 to 20,000 g/mol, and it does not contain hydroxy groups, carboxyl groups or amino groups which react with isocyanate groups.
US10190014B2	Surface-treating agent for vulcanized rubber A surface-treating agent for vulcanized rubber, comprising, based on 100 parts by weight, as solid matters, of isocyanate group-containing 1,2-polybutadiene, an organic solvent solution containing 10 to 160 parts by weight of fluororesin particles and 2.5 to 20 parts by weight of a perfluoroalkyl group-containing oligomer-based, fluorine-containing surfactant as a dispersant. The surface-treating agent for vulcanized rubber improves the solution stability of the organic solvent solution, improves the further hardness of the entire coating film formed from the surface-treating agent, abrasion resistance, and product torque evaluation, and is effectively used as, for example, a coating agent for seal lip parts of oil seals.
US10190011B2	Ink jet recording method, ink jet ink composition, and ink set An ink jet recording method includes: forming a first image layer by ejecting a first ink composition that contains resin particles, an organic solvent, and water on a recording medium by an ink jet method; first drying in which 80% by mass or more of water contained in the first ink composition of the first image layer is evaporated; and forming a second image layer by ejecting a second ink composition that contains water, and an organic solvent by which the resin particles contained in the first ink composition dissolve or swell on the first image layer subjected to the first drying by the ink jet method, in which the content of an organic solvent having a normal boiling point of higher than 250° C. in the first ink composition and the second ink composition is 2% by mass or less, respectively.
US10190004B2	Peelable coating A peelable coating and method of applying to a substrate. The peelable coating comprising: a base layer that can be peelable applied to the substrate; and a pre-manufactured reinforcing layer for applying atop the base layer. The peelable coating base layer can be a liquid applied base layer having a peelable property when dry.
US10190003B2	Degradation-resistant scale inhibitors Methods for reducing aluminosilicate containing scale in an alumina recovery process involving treating an alumina recovery process equipment surface with a degradation-resistant scale inhibiting composition having high ionic strength prior to exposure to an alumina recovery process stream.
US10190002B2	Aqueous multi-stage emulsion copolymer compositions for use in joinery applications The present invention provides aqueous compositions for use in coating wood joinery, especially for exterior use, comprising (a) one or more dihydrazide compounds in a total amount of from 0.5 to 4 wt. %, based on the total weight of composition solids and (b) of one or more aqueous multistage emulsion copolymers containing, as (i) a first stage, an emulsion copolymer having a glass transition temperature (Tg) via differential scanning calorimetry (DSC) of from −50 to 30° C., and containing, in copolymerized form one or more monoethylenically unsaturated phosphorous acid monomers and, one or more keto group containing amide monomers, and, as (ii) a second stage, an emulsion copolymer having a DSC Tg of at least 50° C. to 125° C., wherein the weight ratio of (i) the first stage to (ii) the second stage, based on copolymer solids, ranging from 50:50 to 90:10.
US10190000B2	Systems for producing a plurality of coating compositions having predetermined VOC contents and methods for making such systems A method of making a system for producing coating compositions having a predetermined VOC content includes preparing a paint comprising a resin and a solvent and having the predetermined VOC content or less. Temperature adjusters are prepared containing a resin and having the predetermined VOC content or less. Each temperature adjuster includes a different solvent or a different amount of a solvent compared to the others such that each of the coating compositions formed from one of the temperature adjusters is suitable for application within an ambient temperature range based on a rate of evaporation of the solvent within the ambient temperature range. Each temperature adjuster has no less than 1 wt. % solids based on the total weight of the temperature adjuster. The paint and the temperature adjusters are provided together as the system.
US10189997B2	Colorant including a mixture of pigments A colorant including a mixture of pigments is disclosed. The pigments have a similar coloration but different resistance to corrosion. The mixing ratio is selected to optimize the corrosion resistance against color brightness, and/or acidic corrosion resistance against alkali corrosion resistance of the colorant.
US10189996B2	Anthracene-based organic dye Disclosed herein is an anthracene-based organic dye represented by Formula (1): wherein the substituents contained in Formula (1) are as defined herein. The anthracene-based organic dye may be used as a photosensitizer in dye-sensitized solar cells to effectively absorb light having a wavelength range which covers the entire visible light wavelength range and which even expands to a near infrared wavelength range and convert the absorbed light into photoelectric current.
US10189989B2	Polyester mixture including polyethylene 2,5-furandicarboxylate The present invention relates to a polyester mixture comprising: i) from 95 to 99.95% by weight, based on components i and ii, of a polyester selected from the group consisting of: polybutylene terephthalate, polycyclohexylenedimethylene 2,5-furandicarboxylate, polybutylene adipate-co-terephthalate, polybutylene sebacate-co-terephthalate, polybutylene succinate-co-terephthalate, polybutylene 2,5-furandicarboxylate-co-succinate, polybutylene 2,5-furandicarboxylate-co-adipate, polybutylene 2,5-furandicarboxylate-co-azelate, polybutylene 2,5-furandicarboxylate-co-sebacate, polybutylene 2,5-furandicarboxylate-co-brassylate, polybutylene 2,5-furandicarboxylate-co-1,18-C18-dicarboxylate, polybutylene succinate, polybutylene adipate, polybutylene succinate-co-adipate, polybutylene succinate-co-sebacate, polybutylene sebacate or mixtures of 2 or more of the polyesters mentioned, and ii) from 0.05 to 5% by weight, based on components i and ii, of polyethylene 2,5-furandicarboxylate.
US10189988B2	High-CTI and halogen-free epoxy resin composition for copper-clad plates and use thereof A high-CTI and halogen-free epoxy resin composition for copper-clad plates and uses thereof is provided. The formula of the high-CTI and halogen-free epoxy resin composition for copper-clad plates comprises 100˜140 parts of halogen-free phosphorous epoxy resin, 10˜35 parts of dicyclopentadiene phenolic epoxy resin, 32˜60 parts of benzoxazine, 1˜5 parts of phenolic resin, 0.05˜0.5 parts of accelerants; and 25˜70 parts of fillers, by weight. The copper-clad plates, prepared according to embodiments of the present invention, can reach the requirements of high CTI (CTI≥500V), high heat resistance (Tg≥150° C., PCT, 2 h>6 min) and the level of flame retardance of UL-94 V0, and they are widely used in the electronic materials of electric machines, electric appliances, white goods and so on.
US10189987B2	Pneumatic tire The present invention provides a pneumatic tire provided with a tread formed from a rubber composition that can achieve balanced improvements in fuel economy and wet-grip performance. The present invention relates to a pneumatic tire provided with a tread formed from a rubber composition, the rubber composition containing a rubber component, silica, and a specific silane coupling agent, the rubber component containing, based on 100% by mass of the rubber component, not less than 5% by mass of a conjugated diene polymer containing a constituent unit based on a conjugated diene and a specific constituent unit, at least one terminal of the polymer being modified with a specific compound, the rubber composition containing the silica in an amount of 5 to 150 parts by mass relative to 100 parts by mass of the rubber component.
US10189986B2	Acrylamide-based copolymers, terpolymers, and use as hydrate inhibitors Copolymers having General Formula (I): in which R1, R2, and R3 are chosen from C1 to C30 aliphatic groups, R4 is chosen from divalent C4 to C7 linear aliphatic groups and divalent C4 to C7 linear heteroaliphatic groups, optionally substituted with one or more C1-C6 linear aliphatic groups, C1-C6 branched aliphatic groups, or combination thereof, R5, R6, and R7 are each independently chosen from methyl or hydrogen, x is chosen from 0 to 0.8, y is chosen from 0 to 0.8, when y is 0, x is greater than 0, and when x is 0, y is greater than 0, and z is chosen from 0.1 to 0.9. The summation of x, y, and z equals 1. Methods for inhibiting formation of clathrate hydrates in a fluid capable of forming the clathrate hydrates, including contacting the fluid with at least one copolymer of General Formula (I).
US10189980B2	Process for producing thermoplastic resin composition A process for producing a thermoplastic resin composition in which the continuous phase comprises an ethylene/vinyl alcohol copolymer (A) and a polyamide resin (B) and the dispersed phase comprises an acid-modified polyolefin elastomer (C), the process being characterized by comprising: step (I) in which an ethylene/vinyl alcohol copolymer (A) and an acid-modified polyolefin elastomer (C) are kneaded to form a mixture in which the acid-modified polyolefin elastomer (C) has been dispersed in the ethylene/vinyl alcohol copolymer (A); step (II) in which a polyamide resin (B) is subsequently added to the mixture obtained in step (I), and the resultant mixture is further kneaded; and step (III) in which a terminal-blocking agent (D) for the polyamide resin (B) is subsequently added to the mixture obtained in step (II) in an amount of 0.1-5 parts by mass per 100 parts by mass of the polyamide resin (B), and the resultant mixture is melt-kneaded at a temperature not lower than the melting point of the polyamide resin (B).
US10189978B2	Rubber composition comprising a highly saturated diene elastomer The present invention relates to a rubber composition based on a reinforcing filler and on an elastomer matrix comprising a highly saturated diene elastomer comprising at least five distinct units of A, B, C, D and E distributed randomly within the elastomer at respective molar fractions of m %, n %, o %, p % and q %, where m+n+o+p+q=100; m≥50; n+o+p+q≥10; and 15≥p+q≥2.This rubber composition enables a satisfactory degree of stiffness to be reached while maintaining hysteresis properties acceptable for use in the manufacture of tires for running vehicles.
US10189976B2	Curable composition comprising an ethylene polymer, a monoperoxycarbonate and a T-alkyl hydroperoxide The present invention pertains to a curable composition comprising (a) at least one ethylene polymer, (b) at least one monoperoxycarbonate, and (c) from 0.05 to less than 0.4 part by weight of at least one t-alkyl hydroperoxide for 100 parts by weight of constituent (b). It is also directed to a method for preventing scorching of a curable composition comprising an ethylene polymer by adding a specific amount of t-alkyl hydroperoxide thereto.
US10189975B2	Cable fill composition A cable fill composition for an optical fiber cable, said cable fill composition comprising (i) a Fischer-Tropsch derived base oil; and (ii) a thickening system, wherein the thickening system comprises at least one block copolymer. The cable fill composition of the present invention provides improvements in rheological characteristics, low temperature properties, and colour stability properties, as well as minimizing the levels of additives such as antioxidants and pour point depressants which need to be used.
US10189974B2	Tire A purpose of the present invention is to provide a tire assuring that clogging of snow and sticking of snow are inhibited, particularly a tire assuring that clogging of snow and sticking of snow can be inhibited and having good performance on ice and snow and abrasion resistance without depending on the tread pattern form while maintaining wet grip performance and abrasion resistance. The tire is composed of a rubber composition which comprises a rubber component comprising a modified butadiene rubber and silica and has a pure water contact angle of from 125° to 140°.
US10189967B2	Macroporous photonic crystal membrane, methods of making, and methods of use In accordance with the purpose(s) of the present disclosure, as embodied and broadly described herein, embodiments of the present disclosure, in one aspect, relate to macroporous photonic crystal membranes, structures including macroporous photonic crystal membranes, devices including macroporous photonic crystal membranes, methods of using macroporous photonic crystal membranes, methods of making macroporous photonic crystal membranes, and the like.
US10189965B2	Production of viscoelastic polyurethane systems using block polymers having bonded siloxane blocks as cell openers The use of bonded siloxane block polymers of the general average formula (I) MaM1bDcD1d TeQfGg as additive in the production of PUR foam using at least one polyol component and at least one isocyanate component, wherein the polyol component used has an average hydroxyl number, determined to DIN 53240-1:2012-07, of >56 to <450 mg KOH/g, preferably 57-300 mg KOH/g, and wherein the PUR foam is produced at an isocyanate index of 65 to 108, is described.
US10189958B2	Organic polymeric particles, paper coating compositions and methods A method of forming an organic polymeric particle, comprising (i) forming a core of an organic hydrophilic polymer with monomers that contains an acid group, a latent acid group, or a combination thereof; (ii) forming a shell that comprises an organic polymer with monomers that contains an acid group, a latent acid group, or a combination thereof to encapsulate the core, where the shell has an initial size; expanding the core to form a hollow porous structure from the shell, where the hollow porous structure has an expanded size larger than an initial size of the shell; and (iii) hydrolyzing the acid group, the latent acid group or the combination thereof of the hollow porous structure and the organic hydrophilic polymer to give the organic polymeric particle a void volume fraction of 40 percent to 85 percent.
US10189956B2	Polymer substrates formed from carboxy functional acrylamide A polymer substrate, such as a polymer particle, is formed from a carboxyl functional monomer. In an example, the carboxyl functional monomer has a protection group in place of the OH of the carboxyl group. Once the monomer is polymerized, such a protection group can be removed, providing a polymer network with carboxyl functional sites. Such sites can be used to attach other functionality to the polymer substrate.
US10189953B2	Temperature-resistant silicone resins Methods and formulations for modified silicone resins of Formula (II) are presented. Formula (II) comprises at least one of each of the following subunits: The R1, R2, R3, R6, R7, R8, R9, R10, R11, R12 and R13 are each independently selected from a group consisting of H, alkyl, alkenyl, alkynyl, and aryl. The X is selected from a group consisting of arylene, transition metal, inorganic oxide, and silsesquioxane. The values of t ranges from 1 to 10, y ranges from 1 to 200 and z ranges from 1 to 1,000. The elastomeric materials prepared from modified silicone resins display robust mechanical properties following prolonged exposure to high temperatures (e.g., 316° C. or higher).
US10189949B2	Transparent polyimide copolymer, polyimide resin composition and molded article, and production method of said copolymer Provided are: a transparent polyimide copolymer which satisfies solvent solubility, storage stability, heat resistance, mechanical strength and thermal yellowing resistance at high levels and has excellent utility; a polyimide resin composition; a molded article; and a production method of the copolymer. The transparent polyimide copolymer is obtained by copolymerizing: (A) 4,4′-oxydiphthalic dianhydride and/or 2,2-bis(3,4-dicarboxyphenyl)hexafluoropropane dianhydride; and (B) at least one diamine and/or diisocyanate represented by the following Formulae (1) to (3): (wherein, X represents an amino group or an isocyanate group; R1 to R8 each independently represent a hydrogen atom, an alkyl group having 1 to 4 carbon atoms, an alkenyl group having 2 to 4 carbon atoms or an alkoxy group having 1 to 4 carbon atoms; and at least one of the R1 to R8 is not a hydrogen atom).
US10189942B2	Polyorganosiloxane, polycarbonate-polyorganosiloxane copolymer, and production method therefor Provided is a polyorganosiloxane, wherein a value obtained by integrating dw/d log(M) from 2.5≤log(M)≤3.1 is 0 to 10% of a value obtained by integrating dw/d log(M) over the entire range of log (M) in a differential molecular weight distribution curve, wherein the differential molecular weight distribution curve is determined by gel permeation chromatography using the polystyrene calibration curve, has an x-axis showing a logarithmic value log(M) of a molecular weight M and has a y-axis showing dw/d log(M) obtained by differentiating a concentration fraction w with respect to the logarithmic value log(M) of the molecular weight.
US10189935B2	Water soluble cross-linked block copolymers The invention provides new water soluble polymers for the use in industrial processes, where large quantities of water is handled, such as sludge dewatering and papermaking. These new polymers are water soluble cross-linked block copolymers, wherein the block copolymers are cross-linked together using a cross-linking agent. Each of the block copolymers contain two different blocks, and these blocks are formed from different monomers. The blocks are linked together with a molecular spacer derived from a bifunctional initiator used during the polymerization of the blocks. The monomers used in polymerizing the blocks are different with each other and they are selected from a group consisting of N-vinylformamide, acrylic acid, acrylamide and water-soluble derivatives thereof.
US10189934B2	Preparation of molecularly imprinted polymers A polymerization process, preferably a living radical polymerisation process, is carried out in the presence of a template substance, to produce molecularly imprinted polymers (“MIPs”). It is controlled so that the products are quite small (500-106 Daltons) so that they are soluble or form colloidal suspensions. The template substances are immobilized templates, which can be re-used. Immobilized templates are also useful for purification of MIP solutions/suspensions by affinity chromatography.
US10189932B2	Thermoplastic molding compounds with an optimized residual monomer content The present invention relates to a process for the production of styrene graft copolymers comprising addition and graft copolymerization of styrene monomers A1 and vinyl cyanide monomers A2 to a graft base B where the ratio by mass of A1 to A2 in the monomer feed at the end of the monomer feed time is lower than the ration by mass integrated over the entire monomer feed time. The present invention further relates to a graft copolymer obtainable by a process according to the invention, a molding composition comprising such a graft copolymer, and a molding obtained from such a molding composition.
US10189928B2	Curable composition, pattern forming method, pattern, and method for manufacturing device Provided are a curable composition having excellent releasability and ink jet discharge accuracy, a pattern forming method, a pattern, and a method for manufacturing a device.The curable composition includes a polymerizable compound and a photopolymerization initiator, in which neopentyl glycol diacrylate accounts for 10% by mass or more of the polymerizable compound, and the total content of a compound represented by the following Formula (I) and a compound represented by the following Formula (II) is 5% by mass or less with respect to the content of neopentyl glycol diacrylate.
US10189927B2	Ionomer having high oxygen permeability The present invention aims to provide an ionomer that can exhibit high oxygen permeability, especially under both low- and high-humidified conditions, and high power generation durability. The high oxygen permeable ionomer includes a specific repeating unit A and repeating unit B and has an equivalent weight of 250 to 930 and a glass transition temperature of 100° C. to 130° C.
US10189923B2	Producing polyolefin products Catalyst systems and methods for making and using the same. A method of polymerizing olefins to produce a polyolefin polymer with a multimodal composition distribution, includes contacting ethylene and a comonomer with a catalyst system. The catalyst system includes a first catalyst compound and a second catalyst compound that are co-supported to form a commonly supported catalyst system. The first catalyst compound includes a compound with the general formula (C5HaR1b)(C5HcR2d)HfX2. The second catalyst compound includes at least one of the following general formulas: In both catalyst systems, the R groups can be independently selected from any number of substituents, including, for example, H, a hydrocarbyl group, a substituted hydrocarbyl group, or a heteroatom group, among others.
US10189920B2	Hybrid supported catalyst system and method of preparing polyolefin using the same Provided are a hybrid supported catalyst system and a method of preparing a polyolefin using the same. The hybrid supported catalyst system according to the present invention may be used to perform oligomerization and copolymerization of olefin monomers in a single reactor at the same time with high efficiency without a separate process of preparing alpha-olefin. Therefore, costs for preparing or purchasing comonomers which are expensive raw materials may be reduced, thereby reducing the production cost of a final product.
US10189919B2	Acetalized polyvinyl alcohol barrier coatings An in situ method of preparing modified polyvinyl acetals is described with the aim of improving the alcohol tolerance while retaining barrier properties of the base polymer.
US10189918B2	Curable fluorocopolymer formed from tetrafluoropropene The present invention is directed to partially fluorinated copolymers and the production thereof. More specifically, the copolymers, which are preferably produced by a solution polymerization process, preferably have at least three units, the first unit selected from 2,3,3,3-tetrafluoropropene and 1,3,3,3-tetrafluoropropene, the second unit having a polymerized monomer selected from the vinyl esters and vinyl ethers, and the third unit having a polymerized monomer derived from a hydroxyl group-containing vinyl ether. The resulting copolymer is environmentally friendly, has favorable molecular weight characteristics, and may be shipped economically in high concentration.
US10189913B2	Biopolymers having coiled nanostructures and processes incorporating the biopolymers The present disclosure is generally directed to biopolymers having coiled nanostructures, methods of making those biopolymers, and applications involving those biopolymers. Biopolymers having coiled nanostructures may be produced through a biophysical process by which the shape of a biopolymer macromolecular chain is altered. Biopolymers having coiled nanostructures may then be cross-linked to prepare biopolymeric networks. The biopolymeric networks may be configured to incorporate solid particles, in which they serve to hold the solid particles together against external stresses, solvents, and the like. For this reason, the biopolymers having coiled nanostructures are useful in a variety of applications, including in an improved process for forming iron ore pellets.
US10189911B2	Innovative discovery of therapeutic, diagnostic, and antibody compositions related to protein fragments of Valyl-tRNA synthetases Provided are compositions comprising newly identified protein fragments of aminoacyl-tRNA synthetases, polynucleotides that encode them and complements thereof, related agents, and methods of use thereof in diagnostic, drug discovery, research, and therapeutic applications.
US10189909B2	Antibodies to MASP-2 The invention relates to antibodies to MASP-2 and functional equivalents thereof. In particular, the invention relates to MASP-2 antibodies capable of inhibiting the function of MASP-2. The invention furthermore discloses MASP-2 epitopes, wherein antibodies recognizing said epitopes are in particularly useful for inhibiting MASP-2 activity. The invention also relates to methods of producing said antibodies, methods of inhibiting MASP-2 activity as well as to pharmaceutical compositions comprising the MASP-2 antibodies.
US10189907B2	Polynucleotides encoding anti-KIT antibodies Provided herein, in one aspect, are antibodies that immunospecifically bind to a human KIT antigen comprising the fourth and/or fifth extracellular Ig-like domains (that is, D4 and/or D5 domains), polynucleotides comprising nucleotide sequences encoding such antibodies, and expression vectors and host cells for producing such antibodies. The antibodies can inhibit KIT activity, such as ligand-induced receptor phosphorylation. Also provided herein are kits and pharmaceutical compositions comprising antibodies that specifically bind to a KIT antigen, as well as methods of treating or managing a KIT-mediated disorder or disease and methods of diagnosing a KIT-mediated disorder or disease using the antibodies described herein.
US10189903B2	Bispecific chimeric antigen receptors and methods of use thereof to treat cancer The invention is directed to a bispecific chimeric antigen receptor, comprising: (a) at least two antigen-specific targeting regions; (b) an extracellular spacer domain; (c) a transmembrane domain; (d) at least one co-stimulatory domain; and (e) an intracellular signaling domain, wherein each antigen-specific targeting region comprises an antigen-specific single chain Fv (scFv) fragment, and binds a different antigen, and wherein the bispecific chimeric antigen receptor is co-expressed with a therapeutic control. The invention also provides methods and uses of the bispecific chimeric antigen receptors.
US10189902B2	Antibodies to TIGIT The present invention provides antibodies, or antigen binding fragments thereof, that bind to human TIGIT (T cell immunoreceptor with Ig and ITIM domains), as well as uses of these antibodies or fragments in therapeutic applications, such as in the treatment of cancer or chronic viral infection. Such method of treatment include combination therapy with inhibitors of other immunomodulatory receptor interactions, such as the PD-1/PD-L1 interaction. The invention further provides polynucleotides encoding the heavy and/or light chain variable region of the antibodies, expression vectors comprising the polynucleotides encoding the heavy and/or light chain variable region of the antibodies, cells comprising the vectors, and methods of making the antibodies or fragments by expressing them from the cells.
US10189894B2	Rationally designed, synthetic antibody libraries and uses therefor The present invention overcomes the inadequacies inherent in the known methods for generating libraries of antibody-encoding polynucleotides by specifically designing the libraries with directed sequence and length diversity. The libraries are designed to reflect the preimmune repertoire naturally created by the human immune system and are based on rational design informed by examination of publicly available databases of human antibody sequences.
US10189891B2	Affinity chromatography matrix The invention discloses an immunoglobulin-binding protein comprising one or more mutated immunoglobulin-binding domains (monomers) of staphylococcal Protein A (E, D, A, B, C) or protein Z or a functional variant thereof, wherein in at least one of the one or more mutated monomers, the asparagine or histidine at the position corresponding to H18 of the B domain of Protein A or of Protein Z has been deleted or substituted with a first amino acid residue which is not proline or asparagine and wherein, if the amino acid residue at position 57 is proline and the amino acid residue at position 28 is asparagine, then the amino acid residue at the position corresponding to H18 of the B domain of protein A or of protein Z is not serine, threonine or lysine.
US10189886B2	Peptides and combination of peptides for use in immunotherapy against esophageal cancer and other cancers The present invention relates to peptides, proteins, nucleic acids and cells for use in immunotherapeutic methods. In particular, the present invention relates to the immunotherapy of cancer. The present invention furthermore relates to tumor-associated T-cell peptide epitopes, alone or in combination with other tumor-associated peptides that can for example serve as active pharmaceutical ingredients of vaccine compositions that stimulate anti-tumor immune responses, or to stimulate T cells ex vivo and transfer into patients. Peptides bound to molecules of the major histocompatibility complex (MHC), or peptides as such, can also be targets of antibodies, soluble T-cell receptors, and other binding molecules.
US10189884B2	Thioamide-modified peptides and uses thereof The invention includes a thioamide-modified peptide, wherein the thioamide modification increases the in vivo half-life of the peptide. The invention further includes methods of treating or preventing a disease or disorder in a subject in need thereof, the method comprising administering to the subject a thioamide-modified peptide of the invention.
US10189881B2	MPS peptides and use thereof This disclosure provides an isolated polypeptide comprising no more than 35 amino acids, wherein the amino acid sequence comprises, or alternatively consists essentially of, or alternatively consisting of XXXRYSYXXSYX (SEQ ID NO: 1) and equivalents thereof, wherein X is a basic amino acid and Y is a hydrophobic amino acid. Polynucleotides encoding the polypeptides and antibodies that bind to the polypeptides are also provided. Therapeutic and diagnostic uses are further provided.
US10189879B2	DNA-binding protein using PPR motif, and use thereof The object of the present invention is to, by analyzing PPR proteins that act to bind to DNA with a prediction that RNA recognition rules of PPR motifs can also be used for recognition of DNA, find a PPR protein showing such a characteristic. According to the present invention, it was revealed that, with a protein that can bind in a DNA base-selective manner or a DNA base sequence-specific manner, which contains one or more, preferably 2 to 30, more preferably 5 to 25, most preferably 9 to 15, of PPR motifs having a structure of the following formula 1 (wherein, in the formula 1, Helix A is a part that can form an α-helix structure; X does not exist, or is a part consisting of 1 to 9 amino acids; Helix B is a part that can form an α-helix structure; and L is a part consisting of 2 to 7 amino acids), and having a specific combination of amino acids corresponding to a DNA base or DNA base sequence as amino acids of three positions of No. 1 A.A., No. 4 A.A., in Helix A of the formula 1 and No. “ii” (−2) A. A. contained in L of the formula 1, the aforementioned object could be achieved. (Helix A)-X-(Helix B)-L (Formula 1)
US10189873B2	Compositions and methods for inhibiting “stimulator of interferon gene”-dependent signalling The invention provides compounds of the purine cyclic dinucleotide (CDN) class, useful as inhibitors of the STING (Stimulator of Interferon Genes) pathway, and methods of their administration to individuals in need thereof.
US10189872B2	Crystalline form of nicotinamide riboside Provided are crystalline forms of nicotinamide riboside, including a Form II of nicotinamide riboside chloride: nicotinamide riboside chloride. Also disclosed are pharmaceutical compositions comprising the crystalline Form II of nicotinamide riboside chloride, and methods of producing such pharmaceutical compositions. In other aspects, the present disclosure pertains to methods comprising administering to a subject the crystalline Form II of nicotinamide riboside chloride. The present disclosure also provides methods of preparing the crystalline Form II of nicotinamide riboside chloride. Also provided are a crystalline Form II of nicotinamide riboside chloride that is prepared according to any of the disclosed methods for preparing the crystalline Form II.
US10189871B2	Transition metal complexes for enantioselective catalysis of carbon-carbon, carbon-heteroatom, and carbon-hydrogen bond forming reactions In some embodiments, the present disclosure pertains to a compound, comprising a transition metal complex having the formula Φ-[M (x,y)-L1 (w,v)-L2 (t,u)-L3]p+An−mZ−p−m. In an embodiment of the present disclosure Φ may be Λ. In another embodiment Φ may be Δ. In some embodiments of the present disclosure, M is a transition metal. In a related embodiment, p is an integer corresponding to the oxidation state of M. In some embodiments of the present disclosure, each of x, y, w, v, t, and u independently comprise R. In other embodiments, each of x, y, w, v, t, and u independently comprise S. In an embodiment of the present disclosure, each of L1, L2, and L3 independently is a ligand comprising a substituted diamine. In some embodiments, An− comprises a lipophilic anion, where m is from 1 to 3, and where Z− comprises an optional second anion.
US10189870B2	Crystalline form of oxazolidinone antibiotics and preparation method, composition and use thereof The present invention relates to a novel crystalline form of oxazolidinone antibiotics, which has advantages in the aspects of solubility, hygroscopicity, crystallinity and stability; the present invention also relates to a method for preparing the novel crystalline form, a pharmaceutical composition containing thereof and the use thereof in the preparation of drugs for treating and/or preventing diseases caused by microbial infection.
US10189864B2	Metal complexes based on a bis(2-pyridylmethyl)amine-based scaffold and methods of making the same A catalyst includes a bis(2-pyridylmethyl)amine-based ligand. A method of forming a catalyst, may include: reacting bis(2-pyridylmethyl)amine-based compound with a terminal azide and/or a terminal alkyne in the presence of Cu(I) to form a bis(2-pyridylmethyl)amine-based ligand. A method of using such catalysts may include neutralizing toxicity of at least one organophosphorus-based compound by reacting the organophosphorus-based compound with a bis(2-pyridylmethyl)amine-based ligand-metal complex.
US10189860B2	Hydrates of dolutegravir sodium The invention relates to novel hydrates of dolutegravir sodium and to processes for their preparation. Furthermore, the invention relates to a novel crystalline form of dolutegravir sodium, which is a useful intermediate for the preparation of one of the novel hydrates. In addition, the invention relates to the use of the novel hydrates for the production of pharmaceutical compositions. Finally, the invention relates to pharmaceutical compositions comprising an effective amount of the novel hydrates, to oral dosage forms comprising said pharmaceutical compositions, to a process for preparing said oral dosage forms, and to the use of said pharmaceutical compositions or dosage forms in the treatment of retroviral infections such as HIV-1 infections.
US10189856B2	Use of sGC stimulators, sGC activators, alone and combinations with PDE5 inhibitors for the treatment of systemic sclerosis (SSc) The use of sGC stimulators, sGC activators alone, or in combination with PDE5 inhibitors for the prevention and treatment of fibrotic diseases, such as systemic sclerosis, scleroderma, and the concomitant fibrosis of internal organs.
US10189851B2	CDK inhibitors Compounds of formulae I, II or III, and pharmaceutically acceptable salts thereof, are useful as CDK inhibitors.
US10189845B2	4,6-substituted-pyrazolo[1,5-a]pyrazines as janus kinase inhibitors Compounds of Formula I: and stereoisomers and pharmaceutically acceptable salts and solvates thereof in which R1, R2, R3 and R4 have the meanings given in the specification, are inhibitors of one or more JAK kinases and are useful in the treatment of JAK kinase-associated diseases and disorders, such as autoimmune diseases, inflammatory diseases, rejection of transplanted organs, tissues and cells, as well as hematologic disorders and malignancies and their co-morbidities.
US10189843B2	Fused pyrazole derivative having autotaxin inhibitory activity The present invention provides a compound of formula (1), wherein R1, R2, R3, R4a, R4b, R5a and R5b are as defined in the description, which has an autotaxin inhibitory activity, a pharmaceutical composition comprising the compound as an active ingredient, and a method of prevention or treatment of a disease involving autotaxin, which is characterized by administering the compound.
US10189842B2	Wnt pathway modulators The present invention relates to dihydropyrazolo[1,5-a]pyrimidine compounds of formula I, defined herein, as WNT pathways modulators, processes for making them, and pharmaceutical compositions comprising them. Methods of treatment of conditions mediated by WNT pathway signalling including cancer, fibrosis, stem cell and diabetic retinopathy, rheumatoid arthritis, psoriasis and myocardial infarction, comprising the compounds of formula I are also provided.
US10189840B2	Substituted tricyclic heterocyclic compounds Disclosed are compounds of Formula (I) or a salt thereof, wherein: X is N; W is: (i) —(CR3R3)1-4—; (ii) —(CR3R3)x—Y—(CR3R3)y—; Or (iii) —Y—(CR3R3)2—Y—; and Y, R1, R2, R3, R5, R6, R8, x, and y are defined herein. Also disclosed are methods of using such compounds as modulators of TNFα, and pharmaceutical compositions comprising such compounds. These compounds are useful in treating inflammatory and autoimmune diseases.
US10189839B2	Tricyclic imidazole compounds as inhibitors of tryptophan hydroxylase The present invention relates to compounds of the formula (I) wherein R1a, R1b, R2, R3, and X are as described in the description, to their preparation, to pharmaceutically acceptable salts thereof, and to their use as pharmaceuticals, to pharmaceutical compositions containing one or more compounds of formula (I), to methods for the preparation of such compounds of formula (I), and especially to their use as TPH modulators.
US10189838B2	Aza-oxo-indoles for the treatment and prophylaxis of respiratory syncytial virus infection The invention provides novel compounds having the general formula: wherein R1, R2, R3, R4, R5, R6, W1, W2, W3, A and X are as described herein, compositions including the compounds and methods of using the compounds for the treatment and prophylaxis of respiratory syncytial virus infection.
US10189836B2	Therapeutic compounds, compositions and methods of use thereof Compounds of Formula (I) and methods of use as Janus kinase inhibitors are described herein.
US10189835B2	Derivatives and methods of treating hepatitis B infections Provided herein are compounds useful for the treatment of HBV infection in a subject in need thereof, pharmaceutical compositions thereof, and methods of inhibiting, suppressing, or preventing HBV infection in the subject.
US10189833B2	Solid forms of a compound modulating kinases Solid forms of the compound, [5-(5-chloro-1H-pyrrolo[2,3-b]pyridin-3-ylmethyl)-pyridin-2-yl]-(6-trifluoromethyl-pyridin-3-ylmethyl)-amine HCl salt (Compound I) and its free base, active on the receptor protein kinases c-Kit and/or c-Fms and/or Flt3, were prepared and characterized: Also provided are methods of using the solid forms.
US10189832B2	Crystalline solid forms of a BET inhibitor The present application relates to crystalline solid forms of an inhibitor of BET proteins such as BRD2, BRD3, BRD4, and BRD-t, including methods of preparation thereof, and intermediates in the preparation thereof, where the compound is useful in the treatment of diseases such as cancer.
US10189831B2	Non-nucleoside reverse transcriptase inhibitors Compounds of Formula I: are HIV reverse transcriptase inhibitors, wherein R1, R2, RE, L, M and Z are defined herein. The compounds of Formula I and their pharmaceutically acceptable salts are useful in the inhibition of HIV reverse transcriptase, the prophylaxis and treatment of infection by HIV and in the prophylaxis, delay in the onset or progression, and treatment of AIDS. The compounds and their salts can be employed as ingredients in pharmaceutical compositions, optionally in combination with other antivirals, immunomodulators, antibiotics or vaccines.
US10189830B2	Alkyl-heteroaryl substituted quinone derivatives for treatment of oxidative stress disorders Disclosed herein are alkyl-heteroaryl substituted quinone derivative compounds and methods of using such compounds for treating or suppressing oxidative stress disorders, including mitochondrial disorders, impaired energy processing disorders, neurodegenerative diseases and diseases of aging.
US10189825B2	Heteroaryl compounds and methods of use thereof Provided herein are thiophene compounds, methods of their synthesis, pharmaceutical compositions comprising the compounds, and methods of their use. The compounds provided herein are useful for the treatment, prevention, and/or management of various neurological disorders, including but not limited to, psychosis and schizophrenia.
US10189824B2	Pyrimidine-diamine dual HSP90/TRAP1 inhibitors Provided are novel compounds of Formula (I): pharmaceutically acceptable salts thereof, and pharmaceutical composition thereof, which are useful as dual Hsp90/TRAP1 inhibitors. Also provided are pharmaceutical compositions comprising the novel compounds of Formula (I) and their use in treating one or more cancers.
US10189821B2	Fused 1,4-dihydrodioxin derivatives as inhibitors of heat shock transcription factor I The present invention relates to compounds of formula I as defined herein. The compounds of the present invention are inhibitors of heat shock factor 1 (HSF1). In particular, the present invention relates to the use of these compounds as therapeutic agents for the treatment and/or prevention of proliferative diseases, such as cancer. The present invention also relates to processes for the preparation of these compounds, and to pharmaceutical compositions comprising them.
US10189820B2	Heterocyclic amides useful as protein modulators Disclosed are compounds having the formula: wherein q, r, s, A, B, C, RA1, RA2, RB1, RB2, RC1, RC2, R3, R4, R5, R6, R14, R15, R16, and R17, are as defined herein, or a tautomer thereof, or a salt, particularly a pharmaceutically acceptable salt, thereof.
US10189818B2	5-(5-(2-(3-aminopropdoxy)-6-methoxyphenyl)-1H-pyrazol-3-ylamino)pyrazine-2-carbonitfile (S)-lactate monohydrate The disclosure herein includes 5-(5-(2-(3-aminopropoxy)-6-methoxyphenyl)-1H-pyrazol-3-ylamino)pyrazine-2-carbonitrile (S)-lactate monohydrate that inhibits Chk1/2 and is useful in the treatment of cancer.
US10189817B2	Inhibitors of Bruton's tyrosine kinase The present invention provides a compound, solid forms, and compositions thereof, which are useful as inhibitors of Bruton's tyrosine kinase and which exhibit desirable characteristics for the same. The present invention also provides methods of making provided compound and solid forms.
US10189815B2	2-(3-pyridinyl)-1H-benzimidazole derivative compound and medicine containing same Provided is a compound represented by general formula (1) or a salt thereof as well as a medicine containing the compound or the salt. In the formula, R1, R2, R3, R4, R5, X1, X2, and X3 are defined.
US10189812B2	Bi-benzyl isoquinoline derivative, preparation method and use thereof in hepatopathy treatment and prevention The invention disclosed a compound of general formula (I), a single stereoisomer thereof, a mixture of stereoisomers thereof, and a prodrug, pharmaceutically acceptable salt and metabolite thereof, X1, X2, X3, X4, R1, R2, x, y and z being as defined in the present invention.
US10189809B2	SGC stimulators Compounds of Formula I are described. They are useful as stimulators of sGC, particularly NO-independent, heme-dependent stimulators. These compounds may be useful for treating, preventing or managing various disorders that are herein disclosed.
US10189806B2	Fiber conduit apparatus for conducting chemical reactions and chemical extractions A fiber reaction process whereby reactive components contained in immiscible streams are brought into contact to effect chemical reactions and separations. The conduit reactor utilized contains wettable fibers onto which one stream is substantially constrained and a second stream is flowed over to continuously create a new interface there between to efficiently bring about contact of the reactive species and thus promote reactions thereof or extractions thereby. Co-solvents and phase transfer catalysts may be employed to facilitate the process.
US10189804B2	Method for producing dicarboxylic acid compound It is an object of the present invention to provide an excellent method for producing an excellent therapeutic agent.The solution of the present invention is as shown in the following scheme: wherein R1 represents a C1-C6 alkyl group, R2 represents a C1-C6 alkyl group, and R3 represents a C1-C6 alkyl group.
US10189803B2	Synthesis of therapeutic and diagnostic drugs centered on regioselective and stereoselective ring opening of aziridinium ions Stereoselective and regioselective synthesis of compounds via nucleophilic ring opening reactions of aziridinium ions for use in stereoselective and regioselective synthesis of therapeutic and diagnostic compounds.
US10189802B2	Aminoalcohol lipidoids and uses thereof Aminoalcohol lipidoids are prepared by reacting an amine with an epoxide-terminated compound are described. Methods of preparing aminoalcohol lipidoids from commercially available starting materials are also provided. Aminoalcohol lipidoids may be prepared from racemic or stereochemically pure epoxides. Aminoalcohol lipidoids or salts forms thereof are preferably biodegradable and biocompatible and may be used in a variety of drug delivery systems. Given the amino moiety of these aminoalcohol lipidoid compounds, they are particularly suited for the delivery of polynucleotides. Complexes, micelles, liposomes or particles containing the inventive lipidoids and polynucleotide have been prepared. The inventive lipidoids may also be used in preparing microparticles for drug delivery. They are particularly useful in delivering labile agents given their ability to buffer the pH of their surroundings.
US10189800B2	Method for preparing N-(1,3,4-oxadiazol-2-yl)arylcarboxamides A method for preparing N-(1,3,4-oxadiazol-2-yl)arylcarboxamides of formula (I) is described. The substituents therein are radicals such as hydrogen, alkyl, haloalkyl or aryl.
US10189799B2	Process for preparing substituted phenylisoxazoline derivatives The present invention relates to a process for preparing substituted phenylisoxazoline derivatives.
US10189795B2	Aryl amine substituted quinoxaline used as anticancer drugs The present invention provides new compounds of formula I(a)-I(d) and II, The compounds can inhibit cancerous inhibitor of protein phosphate 2A (CIP2A), can be used as protein phosphate 2A (PP2A) accelerator and oncoprotein SET antagonist, and can treat cancers effectively.
US10189792B2	Method and apparatus for synthesizing a water-soluble hexaaryl biimidazole A method for forming a water-soluble hexaaryl biimidazole, comprising the steps of reacting benzil with a carboxy benzaldehyde and ammonium acetate to yield a carboxy triaryl imidazole, and dimerizing the carboxy triaryl imidazole in an alkaline aqueous solution of potassium ferricyanide to yield a water-soluble salt of a bicarboxy hexaaryl biimidazole.
US10189790B1	Imidazoline compound, mobility control system, plugging agent for gas channeling, and method for carbon dioxide flooding An imidazoline compound, a mobility control system, a plugging agent for gas channeling, and a method for carbon dioxide flooding. The structure of the imidazoline compound is represented by formula (1), in which R is pentadecyl, heptadecenyl, or heptadecyl. A mobility control system that contains the imidazoline compound can interact with carbon dioxide to form a plugging agent for gas channeling, and thereby attains a plugging effect for carbon dioxide channeling in a carbon dioxide flooding process.
US10189789B2	Process for the preparation of androgen receptor antagonists and intermediates thereof The present invention relates to an improved process for the preparation of carboxamide structured androgen receptor (AR) antagonists such as N—((S)-1-(3-(3-chloro-4-cyanophenyl)-1H-pyrazol-1-yl)-propan-2-yl)-5-(1-hydroxyethyl)-1H-pyrazole-3-carboxamide (1A) and key intermediates thereof such as 2-chloro-4-(1H-pyrazol-3-yl)benzonitrile (V). AR antagonists are useful in the treatment of cancer, particularly prostate cancer and other diseases where AR antagonism is desired.
US10189788B2	Substituted N,2-diarylquinoline-4-carboxamides and the use thereof as anti-inflammatory agents The present application relates to novel substituted N,2-diarylquinoline-4-carboxamide derivatives, to processes for preparation thereof, to the use thereof alone or in combinations for treatment and/or prevention of diseases, and to the use thereof for production of medicaments for treatment and/or prevention of diseases, especially for treatment and/or prevention of fibrotic and/or inflammatory disorders.
US10189782B2	Derivatives of indole for the treatment of cancer, viral infections and lung diseases The present invention relates to a new class of indole derivatives, having a particular MKlp2 inhibition profile and useful as a therapeutic agent, in particular for the treatment of cancer, viral infections and lung diseases.
US10189781B2	Onium salt and composition comprising the same The onium salt of the present invention contains predetermined compound A represented by the general formula (1). The composition of the present invention contains the onium salt of the present invention, and an onium salt containing predetermined compound B represented by the general formula (2). The onium salt and the composition of the present invention exert well-balanced excellent physical properties in terms of cold curing properties, storage stability, thermal shock resistance after curing, and moisture resistance.
US10189778B2	Process for the preparation of methionine alpha-hydroxy analogues from sugars and derivatives thereof A process for the preparation of methionine a-hydroxy analogue and derivatives thereof comprising contacting one or more sugars or derivatives thereof with a metallo-silicate composition in the presence of a compound comprising sulphur and a solvent.
US10189771B2	Acrylic adhesive composition from protected photocrosslinking agents Protected photocrosslinkers and their use in two-stage photocuring of (meth)acrylate monomers is described.
US10189769B2	Method for preparation of pharmaceutically acceptable chlorogenic acid The present invention provides one method for the preparation of pharmaceutically acceptable chlorogenic acid, which comprises the following steps: a. Treating the sample aqueous solution; b. Freezing; c. Thawing and filtering; d. Treating the residue organic phase; e. Concentrating and crystallizing; f. Choosing the number of times to repeat steps a-e according to the variability of chlorogenic acid content in samples; g. Drying. If the chlorogenic acid extract is isolated and purified using this method, water-soluble impurities and liposoluble impurities can be well removed, that allows the impurity content of final products has fulfilled the requirements for medicine; meanwhile, the procedures of this method are simple, and organic solvents can be recycled for further use, with low cost. This method can be applied for the further isolation and purification of chlorogenic acid extract obtained by various ways, especially for the preparation of pharmaceutically acceptable chlorogenic acid.
US10189760B2	Method for preparing sitagliptin intermediate via asymmetrical reduction method Disclosed is a method for synthesizing a sitagliptin intermediate, the method comprising: in the presence of hydrogen and a transition metal catalyst having a chiral phosphine ligand, subjecting a compound of formula II to an asymmetric reductive amination with ammonia or ammonium salt in a proper organic solvent under the condition of adding an acidic additive to produce a compound of formula I, wherein, an R- or S-configuration of a stereocenter is represented by *; the compound of formula I of R configuration can be used to prepare sitagliptin, and a reaction formula is as follows: R1 and R2 are each independently selected from hydrogen, C1-C12 linear or branched alkyl, C3-C12 cycloalkyl, C2-C12 alkenyl, C2-C12 alkynyl and C7-C12 arylalkyl. The method has a high yield and a high ee % value, a mild reaction condition and a low production cost, and is simple to operate, convenient to purify, environmental friendly and suitable for industrial production.
US10189750B2	Fertilizer compositions comprising a cellulose nutrient component and methods for using same Aspects of the invention include compositions for fertilizing and remediating soil. Compositions according to certain embodiments include a cellulose nutrient composition, a microbial blend composition, a source of nitrogen, a source of phosphorus and exotic micronutrients. Methods for using compositions of the invention to fertilize and remediate soil and kits having one or more compositions for fertilizing and remediating soil are also described.
US10189749B2	Humic acid lignite coal based liquid fertilizer The disclosed invention relates to novel fertilizing compounds comprising a combination of inorganic fertilizers and humic compounds. The combination produces a marked benefit over either type of substance individually, and also over previously known combinations of organic and inorganic fertilizers. The invention also relates to a method of production of such compounds.
US10189744B2	Use of an epoxide-amine-based multicomponent mortar composition Described is the use of a hardening composition for epoxide-amine-based, multicomponent mortar compositions, particularly the use of one of these epoxide-amine-based, multicomponent mortar compositions for chemical fastening purposes. The multicomponent mortar composition contains (A) a resin component, which comprises as a curable compound at least an epoxide resin and optionally at least one reactive diluent, and (B) a hardener component, which comprises a hybrid hardener, wherein the resin component (A) and/or the hardener component (B) optionally comprises other ingredients selected from among inorganic and/or organic compounds. The hybrid hardener is a mixture of (a) at least one amine, selected from among aliphatic, alicyclic, or aromatic amines, as a hardener, and (b) a novolac resin as catalyst, wherein the novolac resin is contained in a quantity of 30 to 45 percent by weight, relative to the total weight of the hybrid hardener. The use of the hybrid hardener results in a rapid curding of the multicomponent mortar composition, even at low temperatures, with a complete through-curing of the mortar composition. High load values of the cured mortar composition both at low temperatures (+5° C.) and at high temperatures (+50° C.) and improved creep resistance at high temperatures (+50° C.) are hereby achieved. In addition, one can entirely omit the use of free phenols.
US10189742B2	Glass fiber, composition for producing the same, and composite material comprising the same A composition for producing a glass fiber, including the following components with the corresponding percentage amounts by weight: SiO2: 58-62%; Al2O3: 14-18%; CaO+MgO: 20-24.5%; CaO: greater than 14%; Li2O: 0.01-0.5%; Na2O+K2O: less than 2%; TiO2: less than 3.5%; Fe2O3: less than 1%; and F2: less than 1%. The weight percentage ratio of CaO/MgO is greater than 2 and less than or equal to 2.6; and the weight percentage ratio SiO2/CaO is between 3.3 and 4.3. The invention also provides a glass fiber produced using the composition and a composite material including the glass fiber.
US10189741B2	High strength glass-ceramics having petalite and lithium silicate structures Glass and glass ceramic compositions having a combination of lithium silicate and petalite crystalline phases along with methods of making the glass and glass ceramic compositions are described. The compositions are compatible with conventional rolling and float processes, are transparent or translucent, and have high mechanical strength and fracture resistance. Further, the compositions are able to be chemically tempered to even higher strength glass ceramics that are useful as large substrates in multiple applications.
US10189740B2	Optical glass, preform, and optical element An optical glass having a small partial dispersion ratio (θg,F), while having a refractive index (nd) and Abbe number (νd) within desired ranges, is obtained. The optical glass, in mol %, comprises 20.0 to 65.0% of an SiO2 component, 1.0 to 25.0% of an Nb2O5 component, and 1.0 to 35.0% of an Na2O component, and has a refractive index (nd) of 1.62 to 1.75, an Abbe number (νd) of 30 to 42, and a partial dispersion ratio (θg,F) of no greater than 0.594.
US10189737B2	Fiber optic manufacturing in space Aspects of the embodiments are directed to systems and methods for forming an optical fiber in a low gravity environment, and an optical fiber formed in a low gravity environment. The system can include a preform holder configured to secure a preform; a heating element secured to a heating element stage and residing adjacent the preform holder; a heating element stage motor configured to move the heating element stage; a tension sensor; a spool; a spool tension motor coupled to the spool and configured to rotate the spool; and a control system communicably coupled to the heating element stage motor and the spool tension motor and configured to control the movement of the heating element stage based on a rotational speed of the spool. The optical fiber can include a fluoride composition, such ZrF4-BaF2-LaF3-AlF3-NaF (ZBLAN), and can be characterized by an insertion loss in a range from 13 dB/1000 km to 120 dB/1000 km.
US10189736B2	Method of manufacturing a glass roll A method of manufacturing a glass roll, includes: a forming step (S1) of forming, while conveying a glass film, the glass film by a downdraw method; a temporary rolling step (S3) of rolling the glass film while superposing a protective film on the glass film at a downstream end of a path of the conveying in the forming step (S1), to thereby manufacture a source glass roll; and a main rolling step (S4) of unrolling, while conveying the glass film to a downstream side, the glass film from the source glass roll, and then rerolling the glass film while superposing a protective film on the glass film at a downstream end of a path of the conveying, to thereby manufacture a glass roll. Higher tension in a rolling direction is applied to the glass film in the main rolling step (S4) than in the temporary rolling step (S3).
US10189732B2	Algal-sludge granule for wastewater treatment and bioenergy feedstock generation A granular or particulate composition of matter that includes algae and bacteria is described. The algal-sludge granules are generated by incubating a wastewater system with algae under specific quiescent conditions with illumination. Once the algal-sludge granules are present, it is no longer necessary to maintain quiescent conditions, and reaction with wastewater under stirred conditions is possible. The methods described include ab initio generation of the algal-sludge granules, use of the algal-sludge granules to remediate wastewater, and use of the algal-sludge granules to generate biomass. It is believed that the remediation of wastewater by algal-sludge granules will save the energy for wastewater treatment, recover the energy in wastewater in the form of biomass, and reduce the wastewater treatment carbon footprint.
US10189731B2	Underground septic tank Storage tanks, for example, underground septic tanks, and their methods of fabrication are provided. The tanks include a substantially liquid impermeable plastic vessel having a top, a bottom, and sides; a concrete container encasing and retaining the plastic vessel, the concrete container contacting the bottom and at least partially contacting the sides of the plastic vessel; and at least one opening for receiving effluent, for example, waste effluent, into the plastic vessel. The methods of fabricating the tanks include positioning a plastic vessel into an enclosure; introducing concrete into the enclosure about the plastic vessel; allowing the fluid concrete to cure to provide a substantially solid concrete container about the plastic vessel; and removing the plastic vessel having a concrete container from the enclosure. Vessel shape retaining devices are also disclosed. Aspects of the invention are uniquely adapted to underground storage.
US10189728B2	Fluid purification methods, devices, and systems A fluid purification system has cells whose purifying capability can be regenerated. Some of the cells are arranged in series to reach a high level of purification. An automatic valve network is controlled to cycle the cells in a way that levels the loads on each, thereby maximizing the service interval for replacing expired cells, enabling all of the cells to be replaced at the same time after having each contributing approximately equally to the purification load, and operated such that at any one time, at least one cell is regenerated so as to enable continuous up-time.
US10189726B2	Electrochemical desalination for oil recovery Electrically-driven separation systems and methods for use in oil recovery.
US10189725B2	Methods of separating impurities from industrial minerals using electrocoagulation Various embodiments disclosed relate to methods of separating impurities from industrial minerals using electrocoagulation and apparatuses for performing the same. In one embodiment, the present invention provides a method of purifying an industrial mineral composition. The method can include obtaining or providing an aqueous slurry comprising a mineral composition comprising one or more industrial minerals and one or more impurities. The method can include subjecting the aqueous slurry to an electrical current to form at least one coagulation comprising the one or more impurities. The method can include separating at least one of the coagulations from the one or more minerals, providing a purified mineral composition.
US10189722B2	Pressurized gas lifting and gas rejuvenation Devices, processes, systems, and articles of manufacture adapted to treat contaminated fluid, such as organic wastewater, are described. These are described to include lifting contaminated fluids, treating contaminated fluids, or both, through gas application. In certain designs, gas, such as pressurized air, may be used to lift contaminated fluids, such as organic wastewater (i.e., water having contaminating organics of some kind, e.g. residential septic wastewater). In certain designs, gas, such as pressurized air, may also be used to treat fluids interfacing with the gas.
US10189721B2	System and method for using AC and DC sensors for water treatment A system and method are disclosed for automatically operating a high voltage resonance circuit. An embodiment of the system includes one or more coils each coil can be an alternating current (AC) coil or a direct current (DC) coil. An embodiment of the system further includes a microprocessor that issues commands to control amplitude and frequency of pulses of the one or more coils to reach and maintain a resonant condition for water treatment. The microprocessor determines whether a coil is an AC coil or a DC coil by detecting whether a capacitor is connected in series with the coil. An embodiment of the system further includes one or more sensors that measure the quality of water and provide feedback to the microprocessor.
US10189711B2	Methods and systems for recovering phosphorus from wastewater including digestate recycle Methods and systems for removal and recovery of phosphorus from wastewater and producing inorganic phosphorus complexes including digestate recycle.
US10189708B2	Ruthenium on chitosan (ChRu): concerted catalysis for water splitting and reduction A process and catalyst for the in situ generation of hydrogen via the microwave irradiation of a ruthenium chitosan composite catalyst has enabled the convenient reduction of nitro compounds in aqueous medium.
US10189706B2	Method for self-aligning solder-attached MEMS die to a mounting surface A method of attaching a MEMS die to a surface includes centering and rotationally aligning a solder perform on a solder surface of a body, centering and rotationally aligning a MEMS die on the solder preform, and heating the solder perform in a reflow process until the solder is molten and surface tension of the molten solder moves the MEMS die to a position where the surface tensions balance, and the MEMS die is centered on, and rotationally aligned with, the solder surface of the body.
US10189700B2	Integrated circuit (IC) chip with a self-contained fluid sensor and method of making the chip An integrated circuit (IC) chip with a self-contained fluid sensor and method of making the chip. The sensor is in a conduit formed between a semiconductor substrate and a non-conductive cap with fluid entry and exit points through the cap. The conduit may be entirely in the cap, in the substrate or in both. The conduit includes encased temperature sensors at both ends and a central encased heater. The temperature sensors may each include multiple encased diodes and the heater may include multiple encased resistors.
US10189692B2	Systems, devices and methods for restoring shopping space conditions Systems, apparatuses, and methods for restoring shopping space conditions are provided. A system for restoring shopping space conditions comprises a motorized transport unit comprising at least one sensor, and a central computer system comprising a wireless transceiver for communicating with the motorized transport unit. The central computer system being configured to: identify a section of a shopping space having a dropped item, instruct the motorized transport unit to travel to the section of the shopping space and collect information associated with the dropped item using the at least one sensor, determine a characteristic of the dropped item in the section of the shopping space using the at least one sensor of the motorized transport unit, and select a cleaning task from a plurality of cleaning tasks based on the characteristic of the dropped item.
US10189691B2	Shopping facility track system and method of routing motorized transport units Some embodiments include a track system comprising: an elevated track system comprising a series of elevated tracks that are positioned elevated above a sales floor and products distributed over at least a portion of the sales floor of a shopping facility, and configured such that multiple motorized transport units travel along the series of elevated tracks in traversing at least portions of the shopping facility.
US10189690B2	Vehicle lift There is provided a vehicle lift which includes, under the support plate (1) of the vehicle a lifting/lowering mechanism (101) having at least two pairs of levers articulated to one another in an intermediate section, which constitute the two forks, moved by at least one fluid-dynamic actuator (9). The fluid-dynamic actuator (9) acts on an articulated system (10), which supports at least one first roller (20) and at least one second roller (21) arranged on respective axes. The two rollers (20, 21), in the initial step of lifting/opening the fork, are kinematically coupled with two corresponding inclined surfaces.
US10189689B1	Automobile jack system An automobile jack includes a housing having opposed side and end walls defining an interior area. A ramp extends from the housing and includes upper and lower ends. A platform defines a tire-receiving surface. The automobile jack includes a first linkage having an upper arm pivotally connected to a lower arm along a first horizontal axis and a second linkage having an upper arm pivotally connected to a lower arm along a second horizontal axis. Each upper arm is pivotally connected to the platform and each lower arm is pivotally connected to the housing. A threaded yoke is coupled to the second linkage. The jack includes a power screw for selectively changing a distance between the first and second horizontal axes to move the platform between a retracted configuration at which the tire-receiving surface even with the ramp and a raised configuration above the ramp.
US10189683B2	Mobile crane with ballast receiving apparatus The invention relates to a mobile crane having an undercarriage and a superstructure rotatable with respect to the undercarriage about an axis of rotation and having a ballast receiving apparatus arranged at the superstructure and having at least one ballasting cylinder for receiving ballast. In accordance with the invention, the position of the ballasting cylinders receiving the ballast is varied in the ballast receiving apparatus such that the ballast can be received in positions of different distances from the axis of rotation of the superstructure.
US10189681B2	Escalator or moving walkway with at least one access module An escalator or moving walkway comprises two access areas. The escalator or the moving walkway comprises components generating thermal losses that are arranged in at least one of the access areas in a component room. The escalator or the moving walkway comprises at least one walkable access module, which is arranged adjacent to the component compartment. The access module comprises a cavity, wherein at least one opening exists between the component compartment and the cavity, through which the thermal energy of the components generating thermal losses can be transferred from the component compartment to the cavity.
US10189676B2	Apparatus for performing a rescue run in an elevator system by selecting rescue functions to utilize to perform the rescue run and a method of performing same The invention relates to a method and to an apparatus for performing a rescue run with an elevator. In the method information is received from the sensors measuring the operation of the elevator about the points being measured with the sensors in question, one or more rescue run functions are selected on the basis of information received from the sensors, and also a rescue run, including the selected one or more rescue run functions, is performed.
US10189674B2	Image forming apparatus An image forming apparatus including an image forming unit, first and second discharging portions, first and second supporting portions, an image reading portion, and first and second switching portions is provided. The first switching portion switches between causing a sheet bearing an image formed by the image forming unit to be discharged to the first supporting portion by the first discharging portion and causing the sheet to be conveyed toward the image reading portion that reads the image. The second switching portion switches between causing the sheet whose image has been read to be conveyed toward the second discharging portion that discharges the sheet whose image has been read to the second supporting portion and causing the sheet to be conveyed toward the image forming unit. The image reading portion is disposed above the first discharging portion and further on the inside of the apparatus than the second switching portion.
US10189670B2	Paper sheet handling machine and paper sheet handling method A paper sheet handling machine (for example, a banknote handling machine (10)) includes: a storage unit (for example, an escrow unit (20), banknote storages (30), a banknote storage cassette (40)) configured to store a paper sheet transported from a transport unit (16); and a shifting unit (19) provided in the transport unit (16) and configured to shift the paper sheet transported by the transport unit (16), in a width direction orthogonal to a direction in which the paper sheet is transported, according to a position, in the width direction, of a specific member (for example, a tape (136) in the escrow unit (20), a pair of feed rollers of a banknote feeding mechanism (32, 42) provided in the banknote storages (30), a banknote storage cassette (40)) in the storage unit.
US10189669B2	Post-processing apparatus, post-processing method and image forming apparatus with determination of whether or not to perform post-processing Provided is a puncher having activating/inactivating switch for post-processing function. The puncher prevents undesirable post processing even if the switch indicates activation of the post processing. When a puncher which is registered in the image forming apparatus is attached to the puncher, the puncher obtains information indicating whether or not to the post processing using a punch die is activated or not. When the obtained information indicates that the post processing using the punch die is inactivated, even if the switch indicates activation of the post processing, the post processing is not performed.
US10189664B1	Sheet processing apparatus and image forming system A sheet processing apparatus includes a tray, a stapler, a first discharge section, and a controller. A sheet on which an image is formed is stacked on the tray. The stapler is arranged at an upstream side in a first direction which is a sheet discharge direction with respect to the tray, and executes a binding processing on the sheet. The first discharge section moves from a reference position at the upstream side of the tray to the first direction while supporting the sheet, and executes a discharge processing of the sheet. The controller enables the first discharge section to move from the reference position to a downstream side in the first direction and stop at a processing position and drives the stapler to execute the binding processing on the sheet supported by the first discharge section.
US10189660B1	Auxiliary media unit transporter for media processing devices A media processing device with a housing includes: a motorized media unit transporter to drive a media unit along a media processing path between an unprocessed media unit source and a processed media unit output; an auxiliary media unit transporter including a roller connected to a converter, and a bias member connected between the converter and the housing. In a first operating mode, the auxiliary transporter receives the media unit from the transporter to drive the roller and the converter; rotation of the converter deforms the bias member from a resting position to a primed position. In a second operating mode initiated upon rotation of the converter to a bias release position, the auxiliary transporter propels the media unit by releasing the bias member from the primed position to drive rotation of the converter and the roller as the bias member returns to the resting position.
US10189658B2	Stacking device for stacking value documents A stacking apparatus for value documents, having a stack deposit device and a braking device which is arranged along the transport path of the value documents immediately before the stack deposit device. On the transport shaft of the braking device at least one driving roller is firmly mounted and at least one roller rotatably supported on the transport shaft. At least one cam roller is firmly mounted on a braking shaft of the braking device and at least one eccentric roller. By a rotation of the braking shaft, the eccentric roller can electively be brought in engagement with the opposing driving roller so that a value document becomes clamped between these, or be brought out of engagement with the opposing driving roller, so that the value document is no longer clamped between these, but rather is brakable by the engagement between the cam roller and the rotatably supported roller.
US10189657B2	Car dumper dust control system A method and apparatus that reduce release of dust generated during rotary dumping of rail cars in a dumping facility. The method includes removing dust laden air from a space bounded by a backside airflow diverter, a rotational frame, a first baffle and a second baffle while the rotational frame is rotating with a rail car by drawing the dust laden air through a secondary air intake that passes through the backside airflow diverter into a backside hood. A dust control apparatus includes a diverter, overlying a backside hood having a concave curved upper surface; and at least one secondary air intake positioned to pass through the diverter being located approximately where pressure in the backside hood remains neutral or negative relative to a pressure even there is a transient increase in air pressure in a lower portion of the backside hood.
US10189656B2	Shingle with reinforced nail zone and method of manufacturing A method of making a laminated shingle is provided. The method includes coating a shingle mat with roofing asphalt to make an asphalt-coated sheet, adhering a reinforcement member to a portion of the asphalt-coated sheet, covering the asphalt-coated sheet, and optionally covering the reinforcement member, with granules to make a granule-covered sheet, dividing the granule-covered sheet into an overlay sheet and an underlay sheet, wherein the overlay sheet has a tab portion normally exposed on a roof and a headlap portion normally covered-up on a roof, the headlap portion having a lower zone adjacent the tab portion and an upper zone adjacent the lower zone, and wherein the reinforcement member is adhered to the lower zone of the headlap portion and laminating the overlay sheet and the underlay sheet to make the laminated shingle.
US10189653B2	Device for transporting containers, such as beverage bottles A device for transporting containers. The abstract of the disclosure is submitted herewith as required by 37 C.F.R. § 1.72(b). As stated in 37 C.F.R. § 1.72(b): A brief abstract of the technical disclosure in the specification must commence on a separate sheet, preferably following the claims, under the heading “Abstract of the Disclosure.” The purpose of the abstract is to enable the Patent and Trademark Office and the public generally to determine quickly from a cursory inspection the nature and gist of the technical disclosure. The abstract shall not be used for interpreting the scope of the claims. Therefore, any statements made relating to the abstract are not intended to limit the claims in any manner and should not be interpreted as limiting the claims in any manner.
US10189651B2	Item infeed apparatus and method for a palletizer An infeed apparatus includes an item manipulator that orients items such as cases in a desired orientation as determined by a build menu, and a row build apparatus that is synchronized with the manipulator to space items pursuant to the build menu. The manipulator uses a pusher to push items across a friction belt to thereby orient the items, and includes sensors for determining when an item is in an incorrect orientation. The row build receives items from the pusher and is selectively advanced to locate items in a desired relative orientation so that rows of items are built correctly.
US10189650B1	Card for cleaning printed media transport system and method of using same A system for cleaning a media transport device includes a cleaning substrate sized and configured to fit within at least a portion of a media travel pathway of the transport device. The cleaning substrate includes a cleaning face and a locking member that secures the cleaning substrate in a substantially fixed position within the transport device while the transport device is operated. The cleaning substrate also may include scarifying holes that scrape debris from media conveyors of the transport device, and flaps that fit under and clean belts of the transport device. Cleaning the transport device may include opening a section, positioning the cleaning substrate in the section without operating the media conveyors' motor, closing the section and then operating the transport device so that the media conveyors move, contact the cleaning substrate and are cleaned while the cleaning substrate remains substantially fixed within the transport device.
US10189649B2	Conveying system The invention is directed to a conveying system which includes an endless conveyor belt and at least one non-destructive inspection device for inspecting the conveyor belt. The inspection device generates and outputs a result of the inspection. The conveying system has at least one adjustable conveying system element and at least one control unit which adjusts the adjustable conveying system element in dependence on the result of the inspection.
US10189648B2	Flexible auger conveyor Auger conveyors most commonly employed in industries where the horizontal and/or vertical transfer of solids or semi-solid materials is required. Auger conveyors employ a rotating helical screw blade, commonly known as flighting, which rotates about on an inline axis within an inline conduit. Described herein is an auger conveyor which does not need to follow the traditional rule of rotating about on an inline axis. A flexible wire rope shaft is employed to rotate about on an infinite number of axes thereby facilitating an auger conveyor connected to the flexible wire rope shaft through buttons, to traverse a non-linear path.
US10189647B2	Belt-on-belt drives for steeply-sloped portions of long conveyors A conveyor system, at least a portion of which may traverse a continuous slope sufficiently steep such that tensile forces associated with overcoming the effects of the slope are several times larger per unit length of run than tensile forces per unit length of run due to main frictional resistance of the conveyor system, may include a belt-on-belt drive. The belt-on-belt drive may include at least one internal belt configured to operably engage the carry belt of the conveyor system so as to frictionally drive the carry belt over at least a one-third length of the sloped run. At the portion of the external belt driven by the at least one internal belt, the rate of tension change in the external belt may be configured to be approximately zero or a modest rise. In some embodiments, the longitudinal stiffness of the at least one internal belt may be substantially greater than the external belt's longitudinal stiffness.
US10189646B2	Method and apparatus for distributing articles in a storage compartment An apparatus and method for distributing articles made by series production is configured to deliver articles to selected storage positions in side-by-side rows of adjacent storage positions for stacked articles in a storage compartment. After selection of a storage position, a transport platform movably mounted on a horizontally movable carriage above the rows is driven to a location above the selected storage position with the platform moved between two possible positions for dispensing articles into the respective rows, an article conveyor on the platform is actuated to transport the article off the platform into the underlying storage position, where it is stacked on top of any previously stacked articles, and the platform is driven back to a start position to receive the next article. The procedure is repeated to distribute subsequent articles to selected storage positions in the storage area.
US10189644B2	Driving force transmission device and image-forming apparatus Provided is a driving force transmission device including: an actuator (22) that, in a case where one of a first annular gear (11), a second annular gear (14), and a carrier (16) is an input member, another one is an output member, and the remaining one is a rotational member, causes one of the input member and the output member to rotate integrally with the rotational member. When driving force is inputted from the drive source to the input member and input member is rotated unidirectionally, the rotation direction of the output member in the case where one of the input member and the output member rotates integrally with the rotational member is reversed with respect to that in a case where one of the input member and the output member does not rotate integrally with the rotational member.
US10189642B2	Systems and methods for distributed autonomous robot interfacing using live image feeds Described in detail herein is an autonomous fulfillment system. The system includes the first computing system, with an interactive display. The first computing system can transmit a request for physical objects from a facility. A second computing system can transmit instructions autonomous robot devices to retrieve the physical objects from the facility. The second computing system can control the image capturing device of the autonomous robot device to capture a live image feed of the at least one physical object picked up by the at least autonomous robot device. The second computing system can switch an input feed of the first computing system to display the live image feed on the display of the first computing system. The second computing system, instruct the autonomous device to discard the physical objects picked up by the at least one autonomous robot device and to pick up a replacement physical object.
US10189632B2	Aerosol-generating system A handheld aerosol-generating device may include an emitter configured to emit light, a sensor configured to receive light, and an aerosol chamber configured to hold an aerosol. The emitter may emit light into the aerosol chamber. The sensor may receive light from the aerosol chamber and measure at least one wavelength of the spectrum of the received light. Direct measurement of parameters, and/or the presence, of the aerosol in the aerosol chamber may be enabled, where the direct measurement of parameters of the aerosol in the aerosol chamber may enable optimal operation of an aerosol-generating system that may be the handheld aerosol-generating device.
US10189631B2	Method of dispensing a plurality of interconnected wipes A method of dispensing wipes includes providing a stack of wipes. Each wipe is generally rectangular in shape and defines four corners. A dispenser has a dispensing orifice. The method includes grasping a presented corner of a leading wipe, and pulling the presented corner of the leading wipe to withdraw the leading wipe out of the dispenser, whereby the leading wipe releases from a succeeding wipe such that a presented corner of the succeeding wipe, and no other corner of the succeeding wipe, protrudes from the dispensing orifice. In particular embodiments, the presented corner of the leading wipe and the presented corner of the succeeding wipe originate from opposite sides of the stack. In other embodiments, the presented corner of the leading wipe and the presented corner of the succeeding wipe each originate from the same side of the stack.
US10189630B2	Microwavable food products and containers Embodiments of the invention include food products and related methods. In an embodiment, the invention includes a food product. The food product can include a container and a food composition. The container can include a bottom wall and a side wall. The bottom wall can include a microwave reflector. The side wall can include a material that is substantially transparent to microwaves. The microwave reflector can cover at least about 80 percent of the surface area of the bottom wall. In an embodiment, the invention includes a microwaveable food container. The microwaveable food container can include a bottom wall and a side wall. The bottom wall can include a microwave reflector. The side wall can include a material that is substantially transparent to microwaves. The microwave reflector can cover at least about 80 percent of the surface area of the bottom wall. Other embodiments are also included herein.
US10189623B2	Container assemblies for storing, shipping, and/or dispensing fluids, and related methods A container assembly includes a container and a receptacle configured to be positioned within the container. The receptacle has an opening for dispensing fluid, and the container has an opening that aligns with the receptacle opening when the receptacle is positioned within the container. The container opening defines an ergonomic cutout portion for use in grasping the container for carrying the container and receptacle together, and for dispensing fluid from the receptacle when the receptacle is positioned within the container. The container can also include window openings for viewing fluid level in the receptacle when positioned within the container, and a knockout configured to be removed from the container to allow access to the receptacle through the container. And, the receptacle can include a handle for grasping in connection with the ergonomic cutout portion for use in carrying the container and receptacle together and dispensing fluid from the receptacle.
US10189622B2	Pack of single use capsule or pod, packaging machine and method thereof A pack including at least one single-use capsule or pod for a portioned beverage which has two opposite bases, and a side wall connecting the two bases defining therewith a chamber for containing an aromatic substance; the pack has a sealed container for containing the capsule or pod housed in a protective inert gas atmosphere; more specifically the sealed container copies at least in part the shape of the capsule or pod.
US10189609B2	Pouch with rigid handle and supports Provided are pouches with rigid handles and/or internal supports and methods of making such pouches. In one aspect, a pouch with internal support includes a flexible pouch including a fitment coupled to a flexible pouch body and at least one inner support piece coupled to the fitment and extending into the inside of the pouch through the interior of the fitment. The fitment includes a fitment inner engagement feature and the at least one inner support piece includes an inner support engagement feature and at least one inner support extending from the inner support engagement feature. The fitment inner engagement feature and inner support engagement feature are interlocked to keep the at least one inner support piece from falling into or out of the flexible pouch body.
US10189608B2	Plastic bag and plastic bag making apparatus In a plastic bag including a triangular flap which has a folded hypotenuse and an open hypotenuse, a flow path is formed by the folded hypotenuse or the open hypotenuse to discharge air or gas through the flow path.
US10189606B2	Drinking or eating vessel There is provided a drinking or eating vessel comprising an inner surface that defines a volume for receiving liquid or solid food and an outer surface that supports a polymeric coating and a decorative layer, wherein the polymeric coating comprises a polymer formed by curing a coating mixture on the outer surface of the drinking or eating vessel, said coating mixture comprising a matting agent, wherein the polymeric coating has an inner surface in contact with the drinking or eating vessel and an outer surface in contact with the decorative layer, and wherein the decorative layer comprises a dry toner image applied to the outer surface of the polymeric coating. Also provided is a corresponding process for producing the drinking or eating vessel.
US10189605B2	Debris protected twist attachment A detachable attachment assembly has a receptacle unit and a carrier unit. The receptacle unit includes a housing defining a receptacle slot and a piston having a profile substantially matching the receptacle slot. The piston is movable between an engaged position, proximal the receptacle slot, and a retracted position, distal to the receptacle slot. A biasing member biases the piston toward the engaged position. A flange of the carrier unit has a width greater than the length of the receptacle slot. A lock tab is offset from the flange and is configured to pass through the receptacle slot. A first angle of the carrier unit lets the lock tab move the piston from the engaged position to the retracted position. A second angle prevents passage of the lock tab through the receptacle slot. An accessory is attached to the carrier unit.
US10189604B2	Container, packaging, and method for producing same A container comprises a plant based structural layer having an inner surface and an opposed outer surface, and a pre-formed polymeric liner layer secured to the plant based structural layer and lining at least one of the inner surface and the outer surface.
US10189603B2	Passivation, pH protective or lubricity coating for pharmaceutical package, coating process and apparatus A method for providing a passivation layer or pH protective coating on a substrate surface by PECVD is provided, the method comprising generating a plasma from a gaseous reactant comprising polymerizing gases. The lubricity, passivation, pH protective, hydrophobicity, and/or barrier properties of the passivation layer or pH protective coating are set by setting the ratio of the O2 to the organosilicon precursor in the precursor feed, and/or by setting the electric power used for generating the plasma. In particular, a passivation layer or pH protective coating made by the method is provided. Pharmaceutical packages coated by the method and the use of such packages protecting a composition contained in the vessel against mechanical and/or chemical effects of the surface of the package without a passivation layer or pH protective coating material are also provided.
US10189598B2	Display carrier A display carrier has: a storage box which stores a display; a fixing member which fixes the display in the inside of the storage box; a window part which is formed on a face which is opposite to a screen of the display when the display is fixed in the inside of the storage box among a plurality of faces of the storing box; and a closing member which closes the window part.
US10189596B2	Plastic containers having base configurations with up-stand walls having a plurality of rings, and systems, methods, and base molds thereof Plastic containers, base configurations for plastic containers, and systems, methods, and base molds thereof. In particular, the disclosed subject matter involves container base configurations having particular up-stand geometries that can assist or facilitate elevated temperature processing and/or cooling processing of plastic containers.
US10189595B2	Feeding unit for feeding sealed packs of pourable food products A feeding unit for receiving sealed packs of pourable food products from a forming unit arranged to form the packs and feed the packs to a folding unit arranged to fold the packs so as to obtain folded packages, the feeding unit comprising a feeding conveyor to carry the packs towards the folding unit, wherein the feeding unit further comprises a driving arrangement interacting with the packs so as to pull the packs from the forming unit and push the packs towards the feeding conveyor.
US10189590B2	Method for packaging liquid or pasty products and packaging machine suitable for this purpose A method for the portioned packaging of liquid or pasty products using a packaging machine. The product is fed via an inlet to a metering chamber, being metered in the metering chamber by a metering member to form a product portion, and the product portion being fed via a metering outlet to a package. In order to avoid impairments of products which are sensitive to crystallizing out in the inoperative state, the metering chamber is operated in continuous flow in at least one operating state of the packaging machine from the following group: downtimes of the packaging machine, start-up of the packaging machine and operation of the packaging machine, by the product—whether entirely or in a partial flow—being removed entirely or partially from the metering chamber past the metering member via an outlet provided in addition to the metering outlet and being recirculated.
US10189589B2	Chamber machine with gas nozzle monitoring The present invention relates to a chamber machine for packaging products in at least one bag, where said chamber machine includes at least one gas nozzle. The chamber machine can also include a monitoring device configured for detecting the presence of a bag neck of the bag over the gas nozzle.
US10189581B2	UAV payload module camera assembly and retraction mechanism In one possible embodiment, a UAV payload module retraction mechanism is provided including a payload pivotally attached to a housing. A biasing member is mounted to bias the payload out of the housing and a winch is attached to the payload. An elongated flexible drawing member is coupled between the housing and the winch, the elongated drawing flexible member being capable of being drawn by the winch to retract the payload within the housing.
US10189579B2	Dynamic exterior aircraft light unit and method of operating a dynamic exterior aircraft light unit A dynamic exterior aircraft light unit, mounted to an aircraft for illuminating an aircraft environment, includes an LED group with a plurality of LEDs, and an optical system with at least one optical element. The optical system being associated with the LED group for shaping an output light intensity distribution from the light emitted by the LED group and the LED group and the optical system are stationary within the dynamic exterior aircraft light unit.
US10189578B2	Self-balancing pressure bulkhead A pressure bulkhead may include a bulkhead wall having a radially inner disk and a radially outer compression ring, the outer compression ring being reinforced to balance meridional and hoop stresses sustained by the bulkhead wall in response to a pressure differential across the pressure bulkhead; and the radially inner disk being unitary with the outer compression ring and being made of the same material as the outer compression ring.
US10189576B2	Liquid storage tank A liquid storage tank, for example an aircraft fuel tank, having a tank wall enclosing a liquid storage space, and a tie assembly located at least partially within the liquid storage space. The tie assembly includes an elongate member, for example a wire or cable, and a plurality of attachment devices fixed to an inner surface of the tank wall. The elongate member includes a plurality of spaced part points along its length, each of the spaced apart points being fixed to a respective attachment device such that the tie assembly resists outward deformation of the tank wall.
US10189572B2	Systems and methods for preventing ice formation on portions of an aircraft An ice prevention system is configured to prevent ice from forming and/or melt ice with respect to one or more portions of an aircraft. The ice prevention system includes a combustor having an air inlet and a gas outlet. A supply air conduit is coupled to the air inlet of the combustor. The supply air conduit is configured to channel low pressure air to the combustor. One or more delivery conduits are coupled to the gas outlet of the combustor. The delivery conduit(s) are configured to be coupled to the one or more portions of the aircraft. The combustor is configured to exhaust heated gas to the delivery conduit(s) through the gas outlet to prevent ice from forming with respect to the portion(s) of the aircraft.
US10189570B2	Seat pan assembly with encased comfort spring A seat pan assembly including spaced left and right seat spreaders and a seat cushion assembly supported on the spaced left and right spreaders, the seat cushion assembly including a spring assembly incorporated within at least one layer of seat foam. A seat cushion assembly including at least one layer of seat foam and a spring assembly having a plurality of springs incorporated into the at least one layer of seat foam such that portions of the at least one layer of seat foam are positioned both above and below the plurality of springs.
US10189565B2	Modular unmanned aerial system with multi-mode propulsion A modular Unmanned Aerial System (UAS) includes an Unmanned Aerial Vehicle (UAV) parent module and UAV child modules. A main wing extends from a respective fuselage of the modules. The UAS includes docking mechanisms coupled to wingtips of the main wings. The child modules dock with the wingtips of the parent or an adjacent child module. Docking forms a linked-flight configuration, with undocking and separation from the parent or adjacent child module achieving an independent-flight configuration. The modules have booms arranged transverse to the main wings and parallel to the longitudinal axis, as well as front and rear rotors/propellers. The front and rear propellers have axes of rotation that are normal to a plane of the longitudinal axis in a vertical takeoff and landing (VTOL) configuration, with the axis of rotation of the rear propellers parallel to the longitudinal axis in a forward-flight configuration.
US10189561B2	Resonator, and an aircraft provided with the resonator A resonator provided with a heavy member comprising a casing fastened a spring blade. The heavy member comprises a set of masses that is movable in translation in said casing along a longitudinal direction. A wormscrew driven by drive means is engaged in a slider nut of said set of masses. The set of masses comprises two masses that are slidable respectively in two cylindrical spaces of the casing. Each mass presents at least two presser means interposed between the mass and the casing, each presser means comprising a groove formed in a circumference of a mass, each presser means comprising at least one resilient member arranged in said groove and a split ring pressed against the casing by said at least one resilient member of the presser means.
US10189555B2	Rotary ball lock latching mechanism A latching mechanism is provided for engaging an aircraft surface panel to a support member. The aircraft panel is provided with a post extending from the lower surface, which extends through a panel support member into a post engagement mechanism. The post engagement mechanism defines a rotatable sleeve, which rotates for locking and unlocking engagement between the post and the post engagement mechanism. Locking engagement continues when power to the post engagement actuator is terminated. The post engagement mechanism may utilize various types of actuators, including mechanical, hydraulic, and pneumatic. The aircraft panel and the panel support member are translatable into and out of abutting engagement independent of the need for any contact with the aircraft panel upper surface.
US10189553B2	Water intake system and floating vessel equipped with such a system Disclosed is a water intake system for a floating vessel in a body of water, which includes within the hull of the vessel an intake compartment for taking in water from the body of water and a distribution compartment for distributing and supplying the water to one or more consumer units within the floating vessel. The intake compartment is arranged below a lowest operational draught of the vessel and has an inlet in a bottom region of the intake compartment. The intake compartment is coupled by a conduit to the distribution compartment for allowing water to flow into the distribution compartment. The water intake system further includes a water lift hose that is connected to the inlet and is extendible below the hull of the vessel.
US10189538B2	Bicycle hydraulic operating device A bicycle hydraulic operation device includes a bracket configured to be attached to a bicycle part. A hydraulic cylinder is provided on the bracket, and a piston is located within the hydraulic cylinder. An attachment bore provided on the bracket, and the attachment bore is connected with the hydraulic cylinder. The attachment bore includes a step. At least part of the attachment bore is arranged in an area that radially surrounds the hydraulic cylinder.
US10189536B2	Bicycle disc brake caliper A bicycle disc brake caliper comprises a caliper body. The caliper body includes a slot in which a brake pad is arranged. The caliper body includes a first body portion, a second body portion, a mounting surface, a first receiving hole, a cylinder bore, and a second cylinder bore. The second body portion is coupled to the first body portion so as to provide a slot therebetween. The mounting surface is configured to face a pipe portion of a bicycle body in a mounted state where the bicycle disc brake caliper is mounted to the bicycle body. The first receiving hole is provided on the mounting surface. The first receiving hole is configured to be threadedly engaged with a fastener to mount the bicycle disc brake caliper to the bicycle body. The first cylinder bore is provided on the first body portion. The second cylinder bore is provided on the first body portion.
US10189530B2	Bicycle handlebar and grip assembly A bicycle handlebar assembly that includes a body having at least two grip areas positioned for interaction with the hands of a rider. The grip portions or grip areas are preferably spaced apart by a center portion that secures the assembly to a bicycle steerer tube. A channel or detent is formed in the body proximate at least one, and preferably proximate each grip portion or grip area. A dampener formed of a different material than the body is disposed in the detent and dissipates at least a portion of vibration of the body to reduce vibrations communicated to the hands of the rider from handlebar vibration. An optional grip assembly cooperates with the handlebar assembly and is constructed to further dampen handlebar vibration.
US10189527B2	Fuel supply device of motorcycle A fuel supply device for a motorcycle having a fuel pump disposed on the outside of a fuel tank for saving with respect to an installation space and for making a fuel pipe connecting the fuel tank and the fuel pump shorter. A fuel supply device for a motorcycle includes a single main frame extending rearwardly from a head pipe; a fuel tank supported on the main frame; an internal combustion engine; a fuel injection device attached to the internal combustion engine; and a fuel supply portion having a fuel pump by which the fuel is supplied to the fuel injection device via a fuel pipe. The fuel pump is provided on the outside of the fuel tank and attached to the main frame in such a manner that an axial line in a direction in which to connect the fuel pipe is aligned along the main frame.
US10189525B2	Handlebar accessory mount A cam lever operated accessory gripping mechanism the gripping mechanism includes a cam lever, a threaded stud, a dowel fixed to a first end of the threaded stud, first and second relatively movable main body sections, the first of the main body sections including a handlebar bracket extension, a first clamping jaw for engaging a first side of the accessory, and an opening shaped to slidably receive the second main body section, and the second main body section including a bore and a slot for receiving a fastening member into which the threaded stud is threaded, and a second clamping jaw for engaging a second side of the accessory. The dowel is rotatably mounted in the camming lever, which has at least one overcenter camming surface that engages a cam-engaging surface of the first main body section, such that pivoting of the camming lever about the dowel in a first direction causes the dowel holding section of the camming level to move in an axial direction of the threaded stud, pulling the second main body section against a biasing force provided by a biasing spring extending between the first and second main body sections, in a direction that causes the second clamping jaw to move towards the first clamping jaw and thereby grip the accessory. Adjustment of the gripping mechanism to fit different accessories is accomplished by turning the threaded stud to cause axial movement of the follower insert and corresponding movement of the second main body section is a desired direction, to adjust the initial spacing of the first and second clamping jaws.
US10189523B2	Handlebar mountable light pipe apparatus for a bicycle There is described a handlebar mountable bicycle light for fitting to a bicycle handlebar (3) between brake levers (4). The bicycle light comprises an upper cover (5) and a lower cover (6) which are preferably made from injection molded plastics and of a clam shell type arrangement able to receive handlebar (3) and rigidly retain light pipe assembly (7) with cover screws (8). Lower cover (6) contains an aperture (14) through which the handlebar stem (9) extends. The light pipe assembly (7) comprises a transparent rod-like light pipe (18) with LEDs (26) mounted at each end of the light pipe (18). The light pipe assembly 7 further includes heat sinks (24) to draw heat away from the LEDs (26). The arrangement is such that when the bicycle light is mounted to the handlebar, the heat sinks (24) are in contact with the handlebar so that heat from the LEDs may be conducted via the heat sinks (24) to the handlebar material.
US10189522B2	Systems and methods for supporting telescoping elements An inner tube moves axially between an outer tube and a support, all of which are concentrically arranged, to a desired telescopic position, relative to the outer tube and the support, and can be locked in the desired telescopic position by applying radial force between the support and the inner surface of the inner tube. The radial force generates a frictional force acting on the inner surface of the inner tube, which resists longitudinal movement of the inner tube. A bicycle actuator cable is coupled to an actuator connector for a tension-controlled actuator by a bicycle cable connector which has a fixed longitudinal position on the bicycle actuator cable. The bicycle cable connector is longitudinally consistently removably repeatably interengageable with the actuator connector to maintain longitudinal alignment of the bicycle actuator cable with the actuator through repeated engagement and disengagement of the bicycle cable connector and the actuation connector.
US10189520B2	Modular system for a vehicle A modular system for a vehicle, in particular a motor vehicle, whereby the vehicle is to be provided with a selected instrument panel and at least one selected door, which can be arranged on the vehicle in a pivotal manner in order to close or release a vehicle door opening adjoining the instrument panel, whereby the modular system has at least two different instrument panels and/or at least two different doors for selection, whereby each instrument panel has a first joint region, and each door has a second joint region which corresponds to the first joint region such that each first joint region and the respective second joint region always form the same joint in the closed position of the door.
US10189519B2	Leg configuration for spring-mass legged locomotion Devices and methods for legged locomotion, including a robotic leg for spring-mass legged locomotion incorporating passive dynamics.
US10189518B2	Track nut with increased bearing area A track nut comprises a main body defining a central aperture with threads disposed in the central aperture, the aperture defining a cylindrical axis and a radial direction, a first end and a second end disposed along the cylindrical axis, and wherein the first end defines an at least partially circular perimeter and the second end defines a generally polygonal perimeter with a plurality of corners, the polygonal perimeter including at least one variable blend portion.
US10189517B2	Deployable aerodynamic side panel system An active side panel assembly having at least one deployable panel(22) and at least one actuator (30). The deployable panel deploys and retracts based on vehicle requirements and provides valuable reduction in vehicle drag, thereby reducing emissions and improving fuel economy. Additionally, it allows for the system to retract so the vehicle can still meet ground clearances, ramp angles, off-road requirements, etc. The active side panel provides a fully deployable system with object detection, declutching of the actuator to help prevent damage, and communication with the vehicle to determine proper deployment and function.
US10189515B2	Aerodynamic control system and method An aerodynamic control system includes a skirt assembly configured to be disposed between plural vehicles in a vehicle system formed from the plural vehicles with the vehicles separated by a spatial gap in the vehicle system. The skirt assembly can include a bladder configured to be inflated with a fluid by a fluid source disposed onboard the vehicle system to cause the skirt assembly to expand between the vehicles from a collapsed state to an expanded state such that the skirt assembly at least partially fills the spatial gap between the vehicles. The skirt assembly can reduce aerodynamic drag exerted on the vehicle system during movement of the vehicle system relative to the vehicle system moving without the skirt assembly in the expanded state.
US10189510B1	Stake pocket insert A stake pocket insert is structured to be positionable in a stake pocket of a vehicle cargo bed side wall. The stake pocket insert includes a stake receptacle defining a stake-receiving cavity and a mounting member secured to the stake receptacle and structured to define an opening leading from an exterior of the stake pocket insert into the stake-receiving cavity. A stake securement mechanism is mounted along a first portion of the stake pocket insert. The stake securement mechanism is structured to be operable to press against a stake positioned in the stake-receiving cavity so as to bias the stake against a bearing surface, thereby securing the stake within the stake receptacle between the stake securement mechanism and the bearing surface.
US10189506B2	Roof sensor housing assemblies that conceal one or more sensors and vehicles incorporating the same A vehicle includes a roof assembly including a roof outer panel having an outer facing surface and a sensor housing recess that extends below the outer facing surface. The sensor housing recess extends in a vehicle longitudinal direction between a front windshield and a rear windshield. A roof sensor housing assembly is mounted to the roof outer panel and extends along a length of the sensor housing recess. The roof sensor housing assembly includes a sensor housing structure that is mounted to the roof outer panel forming a sensor housing volume therebetween. The sensor housing structure extends at least partially above the outer facing surface of the outer roof panel. The sensor housing structure includes a transmission region that has increased transmittance therethrough compared to surrounding regions of the sensor housing structure. A vehicle sensor is located within the sensor housing volume that receives electromagnetic energy through the transmission region and provides a signal that is indicative of an environmental characteristic.
US10189505B2	Side body structure of vehicle A side body structure of a vehicle is provided, which includes a hinge pillar having a hinge pillar member forming, in a side part of the vehicle, a closed section space extending continuously in vertical directions of the vehicle, a side sill having a side sill member forming, on a rear side of the hinge pillar in the side part of the vehicle, a closed section space extending continuously in longitudinal directions of the vehicle, and a closed section space component forming, in a connecting part between a lower end part of the hinge pillar and a front end part of the side sill, a closed section space extending continuously in the longitudinal directions and connecting to the closed section space of the side sill on the rear side, the closed section space of the closed section space component having a vertical dimension that increases toward a front side.
US10189502B2	Wheel beam type axleless vehicle frame The present application discloses a wheel beam type axleless vehicle frame that comprises five sections in sequence from front to back, including a front hanging rack, a front wheel carrier, an intermediate coupling rack, a rear wheel carrier, and a rear hanging rack. Every two adjacent sections amongst the five sections are manufactured and connected in a unified and standardized integrated mode; a modular combination structure is used; and the five sections, which are independent respectively, may be assembled and adjusted according to requirements, and have sufficient strength and stiffness as well as completely independent interchangeability. The vehicle frame has the advantages that match with the needs of an electric vehicle, and thus may be used as the optimum configuration frame for the electric vehicle; and the vehicle frame may be improved according to requirements to be applicable to various fuel and hybrid electric passenger vehicles and commercial vehicles.
US10189500B2	Parking assistance apparatus A parking assistance apparatus includes: an occupant information processing unit configured to process information on an occupant of a vehicle to generate occupant information; a peripheral information processing unit configured to process information on a periphery of the vehicle to generate peripheral information including information on an object in the periphery of the vehicle; and a parking setting unit configured to detect a parkable area which is an area in which the vehicle is parkable based on the peripheral information, and set a parking target position that is a target of parking of the vehicle in the parkable area based on the occupant information.
US10189497B2	Steering column assembly An adjustable steering column assembly comprises a steering column shroud, a support bracket, and a clamp mechanism. The support bracket comprises two arms having a portion of the column shroud located therebetween. The clamp mechanism comprises a pin that passes through slots in the arms and carries a fixed cam portion and moving cam portion, relative rotation of the fixed cam portion and moving cam portion causing the clamp mechanism to move between a locked position and an unlocked position. The fixed cam portion has an anti-rotation feature that sits at least partially within one of the slots in one of the arms and which co-operates with the side walls of the slot to substantially prevent unwanted rotation of the fixed portion of the cam mechanism. The anti-rotation feature carries at least one contact portion that in use contacts the side walls of the slot as the steering column is adjusted and the contact portion and side walls are configured such that in use the anti-rotation feature does not cause any significant permanent deformation of the side walls due to preferential deformation of the contact portion.
US10189496B2	Steering assembly having a telescope drive lock assembly A steering column assembly includes an upper jacket assembly, a lower jacket assembly, a telescope drive assembly, and a telescope drive lock assembly. The upper jacket assembly is at least partially received within the lower jacket assembly. The telescope drive assembly includes a telescope actuator and an extension member. The telescope drive lock assembly is operatively connected to the extension member. The telescope drive lock assembly is configured to facilitate movement of the upper jacket assembly away from the retracted position while an advanced driver assist system is active and the upper jacket assembly is in the retracted position.
US10189495B2	Folding baby stroller system and method A baby stroller for transporting an infant at speeds faster than normal walking is disclosed. This baby stroller can be folded to make it easier to stow and transport. The folding mechanism, a unique feature of the design is directed toward compactness, ease of use, reliability, and reduction in manufacturing costs.
US10189486B2	Railcar with nested sliding gates A railcar system that includes a railcar and a nested sliding gate assembly disposed within the railcar. The nested sliding gate assembly includes an upper deck, a lower deck, and a driving system. The upper deck has a plurality of holes. The lower deck is positioned below the upper deck and has a plurality of discharge ports. The driving system positions the lower deck in a first position with respect to the upper deck, where the holes of the upper deck and the discharge ports of the lower deck do not align when the lower deck is in the first position. The driving system also positions the lower deck in a second position with respect to the upper deck, where the holes of the upper deck and the discharge ports of the lower deck at least partially align when the lower deck is in the second position.
US10189481B2	Social network service (SNS) server for providing profile information of mobile device user An apparatus for providing profile information, in which a mobile device is connected to a vehicle device through a first communication network and connected to a profile information providing server through a second communication network, includes a driving information collection unit configured to collect driving information of a vehicle, a driving state determination unit configured to determine a driving state of a mobile device user based on the driving information, and a communication unit configured to transmit a driving state determination result to the profile information providing server.
US10189478B2	Method for fast change of gears in a vehicle comprising a hybrid driveline A method for shifting in a vehicle (1) with a hybrid powertrain (2), the powertrain includes: a combustion engine (3), an electric machine (4), a gearbox (6) with an input shaft (10) and a main shaft (14), wherein the combustion engine (3) and the electric machine (4) are connected to the input shaft (10); and a lay shaft (16), via gear sets (50, 52 and 58, 60, 62) is connected to the input shaft (10) and the main shaft (14), so that they form a split gear unit (13) and a main gear unit (15). The method has the steps: a) to bring the main gear unit (15) into a substantially zero torque state, b) in the event the input shaft (10) and the lay shaft (16) must both be accelerated or decelerated: to initiate synchronization of the speed of the lay shaft (16) with, on the one hand, the speed of the input shaft (10), and, on the other hand, the speed of the main shaft (14), at a joint first point in time (t1), c) to engage a gear in the split gear unit (13) when the speed of the lay shaft (16) has been synchronized with the speed of the input shaft (10) at a second point in time (t2), and d) to engage a gear in the main gear unit (15) when the speed of the lay shaft (16) has been synchronized with the speed of the main shaft (14) at a third point in time (t3). Also a hybrid powertrain (2) and a vehicle (1), as well as a computer program (P) and a computer program product are disclosed, which perform the method.
US10189476B1	Brake force distribution Brake force distribution via a combination of mechanical braking and regenerative braking techniques is described. In an example, a brake system of a vehicle can detect a braking action and can cause a first negative force to be distributed across two or more wheel assemblies associated with the vehicle. A control system of the vehicle can send a command to at least a power system of the vehicle to cause the power system to affect a second negative force on a first wheel assembly and a positive force on a second wheel assembly to cause an uneven distribution of brake force between the first wheel assembly and the second wheel assembly. As a result, a combined net braking force is applied to the front wheels—the wheels with the most grip—and a reduced net braking force to is applied to the rear wheels to prevent rear-wheel lock-up.
US10189474B2	Vehicle control system and method Embodiments are directed to methods for driving control of a given vehicle in motion. An object detecting transducer that is fixed to the given vehicle is driven in order to detect an object in a detection area at a detection distance away from the given vehicle. A notification message is communicated from the given vehicle to the object in the detection area. The notification message is sent when the object is detected at a too close distance.
US10189473B2	Drive torque control method and drive torque control device for vehicle To provide drive torque control capable of avoiding acceleration failure even when a wheelie occurs.A drive torque control method for a vehicle detects or computes a wheelie amount of the vehicle, reduces drive torque that is applied to a rear wheel to be lower than the drive torque in a normal state when the wheelie occurs, and maintains or increases the drive torque when the wheelie amount is reduced.
US10189466B2	Identifying in-range fuel pressure sensor error Methods and systems are provided for diagnosing an in-range error of a pressure sensor arranged downstream of a lift pump in a fuel system of a vehicle. In one example, a method may include performing feedback control of the lift pump based on output of the pressure sensor, monitoring the pressure sensor output for flattening during the application of the voltage pulses, and adjusting operation of the fuel system depending on whether the pressure sensor output flattens for at least a threshold duration, which is indicative of an in-range error. The method may further include dynamically learning a setpoint pressure of a pressure relief valve of the fuel system and a fuel vapor pressure within the fuel system by monitoring pressure sensor output while adjusting the duty cycle of voltage pulses applied to the lift pump.
US10189465B2	Control method for hybrid vehicle A control method for a vehicle may include shifting request check step of checking whether there is request for shifting in vehicle on the basis of acceleration pedal depression extent and vehicle speed by shifting control device; target engine speed determination step of determining engine target speed on basis of the vehicle speed and gear ratio of pseudo target gear stage by target engine speed determiner when request for shifting is found to have been received as the result of the shifting request check step; and engine speed control step of controlling the engine speed to follow the target engine speed by determining the engine speed control torque on the basis of the difference between the target engine speed and the current engine speed and by applying the determined engine speed control torque to the first motor generator, after the engine target speed determination step.
US10189459B2	Method for operating a vehicle A method for operating a vehicle is disclosed. The vehicle has at least one torque transmission device which when rotating splashes in a fluid, at least two axles each having at least two wheels and at least one controllable coupling device adapted for selectively coupling or decoupling the torque transmission device with at least one of the wheels. The method includes the steps of: in an operating state in which no torque is requested by a driver of the vehicle, decoupling with the control device the torque transmission device and the at least one wheel when a driving speed of the vehicle is greater than or equal to a predetermined speed threshold value and coupling with the control device the torque transmission device and the at least one wheel for torque transmission when the driving speed is smaller than the predetermined speed threshold value.
US10189458B2	Thiol based resin system for removal of copper ions from hydraulic fluid System and method for removing copper species from a hydraulic fluid are described. The system includes a filter including a thiol resin. The filter is configured to be in fluid communication with the hydraulic fluid of the hydraulic system.
US10189449B2	Vehicle cleaning A computer is programmed to, upon determining that obstruction of a window exceeds a first threshold and that a fluid level of a reservoir is above both of two level sensors vertically spaced in the reservoir, pump fluid from the reservoir toward the window; and upon determining that obstruction of an external sensor exceeds a second threshold and that the fluid level is above at least one of the level sensors, pump fluid from the reservoir toward the external sensor.
US10189447B2	End-piece intended to be mounted on a flexible support and wiper including the end-piece and the flexible support The invention concerns an end-piece (1) for a motor vehicle glass wiper including at least one flexible support (3) and a wiper blade intended to be pressed against the glass. The end-piece (1) includes a housing (5) adapted to receive an end portion (6) of the flexible support (3). The end-piece (1) includes means (7) for locking the end portion (6) of the flexible support (3) in an engaged position inside the housing (5). The locking means (7) include at least one tongue (107e). The locking means (7) include at least one cavity (107a) that is delimited at least by a first lateral wall (107b), a second lateral wall (107c) and the tongue (107e).
US10189446B2	End piece for a wiper and corresponding wiping assembly An end piece (100) for a wiper (102) provided with a rigidifying element (110) comprises a channel (120) for receipt of the rigidifying element, as well as first positioning stops (130), and a first means (150) for locking this element.The end piece comprises at least one second positioning stop (140) in order to cooperate equally well with a first or second type of rigidifying element with different dimensions.The first positioning stops (130) are operational when the first type of rigidifying element (110) is inserted in the channel, and at least one second positioning stop (140) is operational when the second type of rigidifying element is inserted in the receipt channel (120).
US10189442B1	Remote vehicle starter and appliance activation system The present invention is a remote vehicle starter and appliance activation system including a base unit, and a remote unit capable of communicating with a remote vehicle starting unit. The base unit can transmit a signal to the remote unit and provide power to a power outlet at a predetermined time. This allows a vehicle's engine to start and an appliance plugged into the power outlet to turn both a predetermined time. The remote unit can be recharged by a charging port connection with the base unit. The base unit can include a support bracket that is engageable with a clip of the remote unit, with the charging port connection being associated with the support bracket and the clip.
US10189441B2	Two step smart key start system A ignition start system in which authentication of a key is carried out twice, first to activate the ignition switch to allow starting the engine and second at the time when the brake pedal is depressed to put the car in a drive gear. The two step authentication prevents driving off in a car that has been started without having the key for security purposes and also to avoid inconvenient situations that can otherwise occur.
US10189439B2	Seat belt retractor and seat belt device Provided are a seat belt retractor and a seat belt device with which it is possible to improve energy absorption characteristics and a restraining property. The seat belt retractor includes a spool that performs winding of a webbing for restraining an occupant, a shaft inserted through an axial center of the spool, and a locking base connected to the shaft and capable of switching between a rotating state and a non-rotating state. The seat belt retractor further includes a load adjustment member disposed between the shaft and the locking base and that blocks or reduces load transmission in a case where a load equal to or greater than a threshold is applied to the shaft, and an energy absorption device disposed between the spool and the locking base and capable of changing an energy absorption amount according to a relative rotation speed between the spool and the locking base. The energy absorption device is connected in parallel with the load adjustment member.
US10189432B2	Vehicle occupant restraint device An occupant restraining device capable of coping with a plurality of collision directions without additional airbags is provided. An occupant restraining device (100) is adapted to restrain an occupant P sitting in a vehicle seat (110), and the device includes a seatbelt (120) fixed to left and right sides of a seat cushion (116) of the seat to restrain the occupant's hips (P2), airbags (130a) and (130b) stored inside a seat back of the seat on the left and right sides thereof and inflated and deployed on the left and right sides of the occupant. Tensile fabric (140) is connected to each of the airbags and the seat cushion and applied with tension, when the airbags are inflated and deployed, so as to be extended between the airbags inflated and deployed and both side surfaces of the seat cushion.
US10189429B2	Vehicle sensor cleaning based on a vehicle occupancy status A vehicle includes a compressor; a first accumulator fluidly connected with the compressor; a second accumulator fluidly connected with the compressor; a first nozzle directed at a first sensor and fluidly connected with the first accumulator; a second nozzle directed at a second sensor and fluidly connected with the second accumulator; an occupancy sensor; and a computer in communication with the compressor, the accumulators, and the occupancy sensor. The computer is programmed to, upon determining that the vehicle is unoccupied based on data received from the occupancy sensor, instruct the compressor to pressurize the accumulators of the vehicle.
US10189427B2	Vehicle and method of controlling a display therein Disclosed are a vehicle and method of controlling a display therein. Herein, the vehicle supports auto driving. The present invention includes sensors, a display including a display area formed on a glass of the vehicle and a controller configured to cause the display to display data obtained via at least one of the sensors on the display area based on an operation mode of the vehicle and vehicle passenger information.
US10189425B2	Using data collected by a personal electronic device to identify a vehicle Apparatus and methods are disclosed for identifying a vehicle using data collected by a personal electronic device residing in the vehicle during its operation. By enabling the vehicle to be identified using data collected by the personal electronic device, embodiments of the invention may allow other information captured by the personal electronic device relating to the user's operation of the vehicle to be associated with the vehicle.
US10189417B1	Sliding automobile roof rack A sliding roof rack includes a base frame which is capable of being removably secured to the roof of an automobile and a movable frame which is configured to either lock in position upon the base frame or be slidingly disengaged and be partially tilted over a side of the vehicle. The sliding mechanism permits an upper portion of the movable frame to remain secured to the base frame while the lower portion of the frame is free to pivot downward along the side of the vehicle.
US10189414B1	Vehicle storage assembly A storage assembly is provided herein. The storage assembly includes a console housing defined by a plurality of surfaces. A member extends along at least one of the plurality of surfaces and is movable along the console housing between a closed position and an open position. The member defines a storage compartment in the open position.
US10189411B2	Interior rearview mirror with GDO module An interior rearview mirror assembly for a vehicle includes a mirror head having a mirror casing and a mirror reflective element, and a mirror mounting structure configured to adjustably mount the mirror head at an interior portion of a vehicle. A receiving portion is configured for receiving a portable self-contained garage door opening module at least partially thereat. The module includes a user input and a housing that houses (i) circuitry, (ii) a transmitter and (iii) a battery. The module is operable to wirelessly transmit responsive to actuation of the user input. With the module at the receiving portion of the mirror assembly, the user input is accessible by the vehicle driver. The module is configured to cooperate with the receiving portion to releasably secure the module at the interior rearview mirror assembly, with the module being releasable from the interior rearview mirror assembly.
US10189410B2	Vehicular visual recognition device In a stowing mechanism of a vehicular door mirror device, sound is produced when a gear plate is rotated from a state in which a clutch plate has been disengaged from the gear plate and the clutch plate engages with the gear plate under biasing force from a coil spring. Butyl tape spans between a portion of the coil spring on an upper side of a gap and a portion of the coil spring on a lower side of the gap such that vibration of the coil spring is suppressed. Accordingly, the sound is able to be damped.
US10189409B2	Vehicle interior rearview mirror assembly with actuator An interior rearview mirror assembly for a vehicle includes a reflective element disposed at a housing. The housing and the reflective element are tandemly and pivotally adjustable about a mounting structure mounted at an interior portion of the vehicle to provide a desired rearward field of view to a driver of the vehicle. A user input is actuatable by the driver of the vehicle. A motorized actuator is operable responsive to actuation of the user input to tilt the reflective element and the housing in tandem about a horizontal axis. Responsive to actuation of the motorized actuator responsive to the user input, the motorized actuator tandemly tilts the reflective element and the housing about the horizontal axis to orientate an outermost front surface of the reflective element more towards the driver or more away from the driver.
US10189406B1	Overhead storage bin utilization detection and display system A storage bin space utilization detection and display system for use with a storage bin for storing one or more objects, including: a plurality of sensors disposed within an interior portion of the storage bin, wherein each of the plurality of sensors is associated with one of a plurality of regions defined within the interior portion of the storage bin, wherein each of the plurality of sensors is operable for detecting a presence/absence of the one or more objects within the associated region defined within the interior portion of the storage bin; and a visual indicator device operable for indicating the detected presence/absence of the one or more objects within the associated region defined within the interior portion of the storage bin to an individual outside of the storage bin.
US10189402B2	Illumination apparatus for vehicle An illumination apparatus for a vehicle includes a projector configured to project an image of visible light; and a processing apparatus configured to predict a travel area of the vehicle after a predetermined time or a predetermined distance of travel, and project an image in the predicted travel area with the projector for illumination of the travel area, the image being indicative of a travel state of the vehicle or a control state of the vehicle.
US10189401B2	Vehicle light strip with optical element A vehicle light strip is provided herein. The vehicle light strip includes a housing member. A light assembly is disposed inside the housing member and has a light source and a photoluminescent structure that is configured to luminesce in response to light excitation by the light source. An optical element is configured to transmit a portion of luminescent light toward a front wall of the housing member and direct another portion of luminescent light toward at least one side wall of the housing member.
US10189398B2	Laser head lamp for vehicle and vehicle A laser head lamp for a vehicle includes: a plurality of lamp modules each comprising a laser diode and configured to output at least one of a low beam or a high beam; at least one processor; and a computer-readable medium coupled to the at least one processor having stored thereon instructions which, when executed by the at least one processor, causes the at least one processor to perform operations comprising: acquiring total operation time of each of the plurality of lamp modules; and controlling, based on the acquired total operation times, at least one first lamp module among the plurality of lamp modules differently from at least one second lamp module among the plurality of lamp modules.
US10189396B2	Vehicle headlamp control device A vehicle headlamp control device includes a headlamp that irradiates an area in front of a vehicle, a camera that captures an image of the area in front of the vehicle, a pedestrian detection portion configured to detect a pedestrian in front of the vehicle from an image captured by the camera, and a control portion configured to control the headlamp and cause the headlamp to irradiate the pedestrian so that a given-shaped part that is not irradiated is formed at a location of an eye of the pedestrian, or a given-shaped part irradiated by dimmed light is formed at the location of the eye of the pedestrian.
US10189393B2	Method and system for operating a tipper There is disclosed a method of operating a tipper comprising a tipper body pivotably moveable with respect to a frame with a hydraulic cylinder disposed therebetween which can be actuated by a hydraulic actuation system to pivot the tipper body. The method comprises receiving at least one lateral state parameter relating to at least one lateral state of the hydraulic cylinder; determining whether the lateral condition of the hydraulic cylinder is within acceptable limits based on the at least one lateral state parameter; and altering, or permitting the alteration of, at least one operational parameter of the hydraulic actuation system if it is determined that the lateral condition of the hydraulic cylinder is within acceptable limits.
US10189392B2	Vehicle center console working surface A center console for a vehicle includes a lid and a pivoting assembly. The pivoting assembly includes a working surface. The working surface is deployable while the lid is in a closed position. The pivoting assembly is independently operable from the lid.
US10189391B2	Adjustable lie-flat seat Described is a passenger seat that includes a seat bottom with a rear edge, the seat bottom including a bottom seating surface and a seat bottom adjustment mechanism where the seat bottom adjustment mechanism forms at least a portion of the bottom seating surface. The passenger seat also includes a seat back extending from the rear edge of the seat bottom, the seat back including a back seating surface and a seat back adjustment mechanism where the seat back adjustment mechanism forms at least a portion of the back seating surface. The adjustment mechanisms may each be configured to move between a deployed configuration and a retracted configuration. The seat bottom adjustment mechanism may be substantially flush with the bottom seating surface in the retracted configuration, and the seat back adjustment mechanism may be substantially flush with the back seating surface in the retracted configuration.
US10189385B2	Vehicle seat A vehicle seat includes a seat part for providing a seat surface for a seat occupant, the seat part including two side parts 21 between which a cross tube 5, 6 extends along a pivot axis, and an adjustment mechanism including a plurality of rockers 31 which are pivotably coupled to the seat part. The cross tube 5, 6 is divided into a long tube element 5 and a short tube element 6. The long tube element 5 extends between the side parts 21 of the seat part and is inserted into openings 210 of the side parts 21. The short tube element 6 is connected in a torsionally locked manner both to a first rocker 31 and to the long tube element 5.
US10189383B2	Vehicle seat A vehicle seat (1) with a seat segment (14) which includes a first seat area (11) with a first backrest (21) that can be pivoted about a pivot axis (A) running in a transverse direction (y) and a second seat area (12) with a second backrest (22) that can be pivoted about the pivot axis (A). The second backrest (22) is equipped with a locking device (9) which interacts with a locking bracket (8) provided on the first backrest (21). The locking device (9) includes at least one axis pin (92) with a longitudinal axis (94) that is inclined relative to the transverse direction (y).
US10189379B2	Seat-position sensing A vehicle seat includes a track coupled to a floor of a vehicle, a seat bottom coupled to the track, and a seat back coupled to the seat bottom to extend upwardly away from the seat bottom. The track interconnects the seat back and seat bottom to the floor to cause the seat bottom and seat back to slide back and forth relative to the floor.
US10189377B2	System and method for adjustment of an assembly A seat assembly includes a first member and a second member located proximate to the first member. An adjustment system for adjustably positioning the first and second members of the seat assembly includes at least one positioning mechanism operatively connected to one or more of the first member and the second member and at least one actuator connected to the at least one positioning mechanism. A control assembly including a housing having a control region, one or more guide surfaces extending from the control region and one or more recessed areas cooperating with the one or more guide surfaces. At least one of the guide surfaces or recessed areas cooperates with at least one switch configured to send a first signal to a controller when a user activates the at least one switch. The controller is configured to generate an activation signal to activate the at least one actuator.
US10189373B2	Seat arrangement A seat arrangement, particularly for a vehicle, that includes a second row seat arrangement. The second row seat arrangement includes a first seat, a second seat and a third seat. The first seat can be stored such that direct access to a third row seat arrangement is not limited by the second row seat arrangement. In a two row vehicle, the second row seat arrangement with the first seat stored provides extra space in the second row for placing cargo.
US10189368B2	Power supply system, transportation apparatus, and method for controlling power supply system A power supply system includes a power transmission electric circuit via which an electrical load is connected to a first energy storage and to a second energy storage. A first charge rate indicates a charge rate of the first energy storage. A second charge rate indicates a charge rate of the second energy storage. A ratio of a first electric power amount of an electric power to be supplied from the first energy storage to the electrical load and a second electric power amount of an electric power to be supplied from the second energy storage to the electrical load is changed in accordance with the first charge rate at least in a first mode among the first mode and a second mode. The second electric power amount in the second mode is smaller than the second electric power amount in the first mode.
US10189367B2	Electric vehicle quick charge control apparatus An electric vehicle quick charge control apparatus includes: a voltage detection unit for detecting the amplitude of a direct current voltage inputted from a charging station; a quick charging unit receiving a power applied from the charging station so as to quickly charge an electric vehicle battery and monitor the status of charge (SOC) information of the battery; and an integrated power control unit for dually controlling the quick charge of the battery on the basis of first discriminant information discriminated by determining the status of charge of the battery from the SOC information of the battery transmitted from the quick charging unit and second discriminant information discriminated by determining the status of charge of the battery from a detected voltage transmitted from the voltage detection unit.
US10189365B2	Charging control system A vehicle is configured to receive electric power from a residence and allow an in-vehicle electric storage device to be charged with the received electric power. A controller estimates a start time of use of the vehicle, calculates a charging start time based on the estimated start time of use of the vehicle and a required time to complete charging of the electric storage device, and provides an instruction to perform charging of the electric storage device. The controller learns a relationship between a use status of a household appliance at the residence before the start of use of the vehicle and a use status of the vehicle, and estimates the start time of use of the vehicle based on the learned relationship and the use status of the household appliance.
US10189358B2	Power supply device An ECU performs a controlling process including: switching a main converter to a boost converter CNV2 when a boost converter CNV1 is set as a main converter and when a first stress value Va is greater than a second stress value Vb; switching a sub converter to the boost converter CNV1; switching the main converter to the boost converter CNV1 when the boost converter CNV1 is not set as a main converter, and when the second stress value Vb is greater than the first stress value Va; and switching the sub converter to the boost converter CNV2.
US10189357B2	Reduced ripple converter for hybrid drive systems A powertrain for a vehicle includes a DC/DC converter and a controller. The DC/DC converter includes an inductor and output capacitor and is coupled between a traction battery and an electric drive unit. The controller may be configured to, in response to an electrical connection between the vehicle and an AC grid, couple the output capacitor and inductor in series and across terminals of the traction battery to absorb reactive power from the AC grid.
US10189356B2	Vehicle control device and vehicle control method A vehicle control device includes: a slip determination module that determines a slip of each of wheels; a base distribution calculation module that calculates a base distribution torque to be distributed to the front and rear wheels on the basis of requested torques and a base distribution ratio of torques between the front and rear wheels, and changes the base distribution ratio on the basis of a result of slip determination performed by the slip determination module when the slip is detected; a rotation speed control module that decreases the base distribution torque on the basis of the result of slip determination, in a manner that a rotation speed of a slipping wheel that is slipping becomes equal to a target rotation speed; and a torque vectoring module that redistributes a torque down amount of the slipping wheel to the base distribution torque of non-slipping wheels that are not slipping.
US10189353B2	On-vehicle structure An on-vehicle structure includes a housing of a motor and a power control unit. The power control unit is fixed by a front bracket and a rear bracket above the housing. A space is defined between a lower surface of the power control unit and the housing. The front bracket includes a base section and a support section. The support section is configured to contact with the housing before the lower surface of the power control unit contacts with an upper surface of the housing when the support section is collapsed rearward by a load applied to the power control unit from front.
US10189352B2	Intelligent safety system for vehicles A safety and emergency-assistance system (1) for vehicles, constituted by at least one bracelet (E), a means for radio/telecommunication of the alarm signal (R1), a black box (BB), a plurality of sensors (S1, S2, S3, S4), and means (X) for remote automatic driving and management of the vehicle (A). In the case of emergency, with the driver/passenger present (A) and unwell while the vehicle is stationary with the engine off and without the key inserted into the ignition, or with the key inserted and the instrument panel off. The system (1) also enables automatic and autonomous activation of the devices present on board the vehicle, e.g. airbags, power window, and air-conditioning system.
US10189351B2	Agitator truck The present disclosure discloses an agitator truck, and the agitator truck includes a frame; a first axle assembly; a second axle assembly, where the second axle assembly and the first axle assembly are disposed along a front-rear direction in a spaced manner, the second axle assembly includes two vehicle axle assemblies that are disposed along the front-rear direction in a spaced manner, each of the vehicle axle assemblies includes an axle case assembly, the axle case assembly includes an axle case component and two half axles, and the two half axles are located inside the axle case component; at least one of the two vehicle axle assemblies is an electric drive axle assembly, the electric drive axle assembly further includes an electric power assembly, the electric power assembly includes a power motor, a transmission, and a differential, the transmission has a transmission case, the power motor is fixed to the transmission case, the differential is supported on the transmission case, the differential is located inside the axle case component, and the transmission case is fixed onto the axle case component; and a suspension system, where each of the vehicle axle assemblies is connected to the frame through the suspension system. The agitator trunk according to the present disclosure high has a compact structure and integration degree and is environmental friendly.
US10189350B2	Fuel drip retention A fuel drip retention system includes a computer programmed to actuate one of a pump or a starter motor to generate a vacuum in an evaporation line between a fuel nozzle receiving port and a vapor canister. The vacuum is generated upon determining that fuel has stopped flowing into a fuel tank.
US10189349B2	Shutter device for vehicle The present invention provides a shutter device for a vehicle in which a manufacturing cost is reduced.Provided is a shutter device (1) for a vehicle, which has: a frame member (10) that has an opening provided therein and is mounted on the vehicle; a fin (20) that extends in a first direction; and a rotary shaft unit (40) that pivotably supports the fin (20) on the frame member to be pivotable in the opening of the frame (10). The fin (20) is provided integrally with or independently from the rotary shaft unit (40), and the fin (20) has a uniform sectional shape in the first direction.
US10189347B2	Engaging device for wheel and wheel set having removable power module An engaging device for a wheel is provided. The engaging device includes a wheel hub and a transmitting member. The wheel hub is located in the center of a wheel. The wheel hub has a plurality of engaging holes. The transmitting member has a plurality of grooves, wherein an elastic member is provided in each of the grooves. One end of the elastic member is connected to the groove, and the other end of the elastic member is connected to an engaging member. The shapes of the engaging members and the engaging holes correspond to each other, so that the engaging members fit into the engaging holes.
US10189346B2	Planetary multi-stage transmission A planetary multi-stage transmission for a vehicle is provided. A drive (An) is connectable by a zeroth shift element (K0) to a first shaft (1). A first element of a first planetary gear set (RS1) is connected to a housing (9). A first shaft (1) is permanently connected to a second element of the first planetary gear set (RS1). A rotor (10) of an electric motor (EM) is connected to a third element of the first planetary gear set (RS1), and the third element of the first planetary gear set (RS1) is connectable by one or more of a plurality of additional shift elements to at least one element of one or more of a second and third planetary gear sets (RS2, RS3).
US10189343B2	Case structure of power equipment unit A case structure of a power equipment unit, which accommodates a power equipment mounted in a vehicle and is disposed in a power equipment unit accommodating part provided on a floor panel, includes: a case body having an upper portion opened to accommodate the power equipment; a lid member which covers the upper portion of the case body; and a cover member which is attached to the lid member and covers at least an opening part formed in the lid member. The cover member has an intake port which takes in air from outside, and a levee wall is provided in front of the intake port.
US10189340B2	Folding tonneau cover apparatus A folding tonneau cover apparatus including a cover assembly and a support frame assembly. The cover assembly having a plurality of rigid panels interconnected in series by a series of flexible hinges preferably made from a laminated woven fabric material. The rigid panels are preferably stiffened by elongated support members secured to the undersides of the respective panels and the top surfaces of portions of the rigid panels are preferably downwardly concave. The cover assembly is secured to the support frame assembly to cover a cargo box of a pickup truck by a plurality of locking members when the support frame assembly is secured to sidewalls of the cargo box. Methods of making a tonneau cover apparatus and methods of folding and unfolding the cover assembly are also disclosed.
US10189339B2	Tonneau cover system for a cargo bed of a vehicle A tonneau cover system includes a plurality of panels coupled to first and second side rails. The panels include a first panel, a second panel, a third panel, and a spacer bar with the spacer bar fixed to the side rails. The first panel pivots relative to the spacer while the spacer remains fixed to the side rails. The third panel pivots relative to the second panel to permit the third panel to be located over the second panel while the spacer remains fixed to the side rails to define an intermediate folded position. The cover further includes a hinge assembly mounted between the second panel and the spacer to enable the second and third panels to pivot relative to the spacer as a unit from the intermediate position to a final position located at least over the spacer bar while the spacer bar remains fixed to the side rails.
US10189334B2	Register In the register 1 of the embodiment, in case that all of the front side fins 41 are rotated to the upward direction, air flowing toward the air outlet 21 (air flow direction X) of the bezel 2 in the air flow path 3A of the retainer 3 is blown out from the air outlet 21 of the bezel 2 and the blowout direction is changed to Y1. At that time, air flow separating from the concave surface existing on the lower surface of the front side fin 41 approaches to air flow along the concave surface existing on the upper surface of the front side fin 41 positioned at a lower position than that of the above front side fin 41, and separates from the fixed fin 22. Thereby, air with superior directivity to the upper direction can be obtained.
US10189327B2	Spring module with negative and positive stiffness springs A strut assembly for a suspension corner employed in a vehicle having a vehicle body and a road wheel includes a damper. The strut assembly also includes an elastic unit having at least one spring module acting in concert with the damper to suspend the vehicle body relative to the road wheel. Each spring module has a positive stiffness spring arranged in parallel with a negative stiffness spring. A vehicle that has a suspension corner employing the elastic unit and is configured to maintain contact between the road wheel and the road surface and provide isolation of vibration between the road wheel and the vehicle body is also contemplated.
US10189325B2	Amphibious vehicle and control method for the same An amphibious vehicle includes: an engine; at least one land traveling device; at least one water propelling device; a power distribution device configured to distribute power outputted from the engine between land travel power to be supplied to the at least one land traveling device and water propulsion power to be supplied to the at least one water propelling device; a slippage-amount detection device configured to detect a slippage amount of the at least one land traveling device relative to ground; and a controller configured to adjust at least the land travel power, of the land travel power and the water propulsion power, on the basis of the slippage amount detected by the slippage-amount detection device. The controller is configured to reduce the land travel power if the slippage amount detected by the slippage-amount detection device is greater than a threshold while the land travel power and the water propulsion power are supplied respectively to the at least one land traveling device and the at least one water propelling device for landing from water to land.
US10189324B2	Method and device for coupling a motor vehicle to a trailer A method for coupling a motor vehicle having a trailer coupling to a coupling element of a trailer with at least partially automatic actuation of the motor vehicle based on data acquired by a surroundings sensor system, for example a surroundings sensor system of the motor vehicle is disclosed. A controlled change in level is carried out at an at least one axle by an air suspension system of the motor vehicle based on the acquired data. A control unit for carrying out the method is also disclosed.
US10189323B2	Trailer coupling The invention provides a trailer coupling including a ball neck movable between an operative position and a rest position. A coupling ball and a pivot bearing unit are fixed to the vehicle. A rotation blocking arrangement has at least two rotation blocking bodies. An actuating body has a respective cam face that runs transversely to the guide direction for each of the rotation blocking bodies arranged to be rotatable about the pivot axis. As a result of the rotary movement in a direction of actuation the at least two rotation blocking bodies are movable in the guide direction. A release position latching arrangement is movable between a latch release position and a latching position that fixes the actuating body in relation to the guide body.
US10189321B2	Air maintenance tire system component protector An air maintenance tire system component protector is provided. An air maintenance tire system includes at least one connecting tube extending between and being in fluid communication with an annular air tube and a valve housing. The protector includes a first end disposed proximate the connection of the at least one connecting tube to the annular tube, and a second end disposed proximate the valve housing. A mid-portion of the protector is disposed between the first and second ends. The protector covers an outboard surface of the at least one connecting tube and the valve housing, and includes means for engaging the at least one connecting tube to secure the position of the tube.
US10189320B2	On-wheel air maintenance system An air maintenance system includes a rotating inner ring secured to a vehicle wheel, a stationary outer ring maintaining a constant angular position, an occlusion roller rotationally fixed to the stationary outer ring, the occlusion roller having a protruding portion centered axially at a radially outer surface of the occlusion roller with axially outer portions of the occlusion roller being radially recessed from the protruding portion and supported by bearing surfaces of the rotating inner ring, spacer rollers rotationally fixed to the stationary outer ring and rotationally supported by the bearing surfaces, and a flexible tube defining a pump cavity, the air maintenance system pumping a fluid from the ambient environment into a pneumatic tire by applying an occluding force against the flexible tube, periodically occluding portions of the pump cavity. The spacer rollers have axially outer surfaces for rotational support by bearing surfaces of the rotating inner ring and a recess centered axially at the outer surface of the spacer rollers for avoiding any contact between the spacer rollers and the flexible tube.
US10189319B2	Tire pressure monitoring systems and methods An improved method for a passenger car tire pressure monitoring system (TPMS), including improvements of a direct TPMS or an indirect TPMS technique. The direct TPMS uses a dynamic tire pressure reference as a tire pressure determination basis, and monitors the real-time tire load, e.g., when the wheel load changes, the TPMS data processing center takes the tire cold inflation pressure data corresponding to the real-time load as the current tire pressure reference, and performs determinations and warnings for the real-time tire pressure data. The indirect TPMS establishes a wheel speed reference database based on a vehicle speed reference, and conducts compensations and corrections for wheel speed distortions caused by the tire wear in use, and performs an analysis and comparison between the compensated and modified real-time wheel speed and the data from the wheel speed reference database, and makes a real-time tire pressure information indication or warning.
US10189318B2	Pneumatic tire having specified grounding tread A pneumatic tire includes a carcass layer, a belt layer, a tread rubber having a cap tread and an undertread, a pair of side wall rubbers, a pair of rim cushion rubbers, and a grounding tread that is exposed to a road contact surface of the tread rubber and that penetrates the cap tread and the undertread to contact the belt layer in an electrically conductive manner. The grounding tread includes a widened portion having a cross-sectional area that widens toward a contact surface with the belt layer at the contact portion with the belt layer. The widened portion of the grounding tread has a profile shape that bulges outward in a tire width direction.
US10189317B2	Pneumatic tire having twisted bead cords A pneumatic tire to reduce separation of a carcass ply from inner and outer core pieces (5i, 5o) and improve steering stability. A radially inner end portion of the carcass ply is held between the inner and outer core pieces (5i, 5o) without turning-up around a bead core. The inner and outer core pieces (5i, 5o) are made of helical body of bead cord (10i, 10o) helically winding around a tire axis. In the inner core piece (5i), the final twisting direction of the bead cord (10i) is the same as the winding direction around the tire axis of the bead cord (10i) in side view from axial outward of the tire. In the outer core piece (5o), the final twisting direction of the bead cord (10o) is opposite to the winding direction of the bead cord (10o).
US10189310B2	Airless tire An airless tire includes a tread ring, a hub and a spoke. The tread ring includes a tread rubber layer, a first reinforcing cord layer on radial direction inner side of the tread layer, a second reinforcing cord layer on radial direction inner side of the first cord layer, and a shear rubber layer between the cord layers, the cord layers have array layers including reinforcing cords, and topping rubber portions covering the array layers, each topping portion has an inner portion adjacent to the shear layer, and an outer portion, and the topping portion(s) has the inner portion formed of a composition including a rubber component which includes a butadiene rubber in content rate of 10 to 100% by mass, an α, β-unsaturated carboxylic acid metal salt in amount of 10 to 80 parts by weight with respect to 100 parts by mass of the component, and a peroxide.
US10189308B2	Drive device for a motor vehicle and motor vehicle having at least one drive device A drive device for a motor vehicle, having a first drive assembly, a second drive assembly, and a wheel axle having a first axle member and a second axle member. The axle members are arranged in the lengthwise direction relative to an axis of rotation of the first axle member and/or the second axle member, at least partially, on sides of the first drive assembly and the second drive assembly lying opposite to one another, and wherein the first axle member is coupled to the first drive assembly and the second axle member is coupled to the second drive assembly in order to transmit torque.
US10189303B2	Bicycle rim for tubeless tire A bicycle rim may control the two beads of the tire with separate bead channels for each bead and a center bridge extending between the two bead channels. A bicycle assembly comprises a bicycle rim having an attachable annular strip formed separately from the bicycle rim and attached to the bicycle rim along a center line of the center channel. The annular strip comprises a set of strip sidewalls and a center section extending between the strip sidewalls, wherein the strip sidewalls are spaced at less than the channel width such that the strip forms a pair of bead channels in cooperation with the channel first outer sidewall and channel second outer sidewall.
US10189302B2	Wheel trim The wheel trim (1) comprises a base element (2) provided with holes (3) and a cover element (4) placed on said base element (2), the cover element (4) being linked with the base element (2) by a speed activation element (5) and said cover element (4) being movable between a rest position, in which the holes (3) are not covered, and an active position, in which the holes (3) are completely or partially covered, when the rotating speed of the wheel is higher than a preset speed, and it is characterized in that the cover element (4) is also linked with the base element (2) by a temperature activation element (6), so that when the temperature sensed by said temperature activation element (6) is higher than a preset temperature, the temperature activation element (6) moves the cover element (4) to said rest position.
US10189301B2	Wheel spider with assembled spoke elements and connection of wheel spider to rim well A wheel includes a rim having a rim well and rim flanges, a hub, and at least three spoke elements. Each spoke element forms at least one spoke between the hub and the rim. The spoke elements are fastened to an inside of the rim in a form-closed manner or a form-closed and bonded manner. In the hub region, the spoke elements are supported on each other in a circumferential direction at abutting surfaces designed therefor. A method for producing the wheel is provided.
US10189299B2	System for mounting a covering upon a frame A system for mounting a covering (e.g., a fabric material) upon a frame is constructed from a plurality of elongated frame parts. Each frame part has two mitered ends and a channel formed therein. The related mounting method includes the steps of: (a) using a jig to hold the fabric material against the frame; (b) inserting a plurality of retaining splines within respective channels so as to capture the fabric material within the channels between one retaining spline and a corresponding floor of the channel, whereby a plurality of corner pleats are formed; and (c) using a tool to invert each corner pleat into a corner joint formed between respective adjacent frame parts so as to form an internal fold at each corner of the frame.
US10189298B2	Device for holding and tilting a container An apparatus and method for holding a container on the apparatus, whereby the container is adapted to include various liquids, including paint, and to automatically tilt when the liquids in the container are reduced to a pre-determined weight. The apparatus includes a top plate, a hinge assembly, and a bottom plate, whereby the top plate is hingedly coupled to the bottom plate by the hinge assembly. A leg extends outwardly away from the bottom plate, whereby the leg is coplanar with the bottom plate. A hook connected to a top end of a bungee cord extends from a top surface of the top plate, and retaining wall protrudes upwardly from the top plate, whereby the retaining wall extends around at least a portion of a perimeter of the top plate. The container is positioned on the top plate and at least partially enclosed by the retaining wall.
US10189297B2	Wall appliqué Implementations of a wall appliqué are provided. In some implementations, a wall appliqué may be used to decorate and/or accent a wall or other suitable surface of a building. In some implementations, a wall appliqué may be used in lieu of traditional shoe moulding, panel moulding, ceiling moulding, door moulding, stair brackets, chair rails, and/or window moulding. In some implementations, the wall appliqué may be applied to a wall or other suitable surface with an adhesive. In some implementations, the wall appliqué comprises a body portion having a front side and a back side. In some implementations, the body portion may have a decorative shape. In some implementations, the front side may have a three-dimensional relief thereon. In some implementations, the wall appliqué may be manufactured from a flexible, polyurethane material. In this way, the wall appliqué may be applied to both flat and irregular surfaces.
US10189290B2	Printer and recording medium The disclosure discloses a printer configured to perform a forcible a first discontinuation control process, a first resuming control process, a second discontinuation control process, and a second resuming control process. In the first discontinuation control process, the printing is discontinued to execute forcible cooling when the detected temperature reaches a forcible cooling temperature. In the first resuming control process, the printing is resumed while doubly forming dots on the print line a print-receiving medium when the detected temperature is decreased to a forcible cooling cancellation temperature after a start of an execution of the forcible cooling. In the second discontinuation control process, the printing is discontinued to execute between-page cooling when the detected temperature reaches a between-page cooling temperature. In the second resuming control process, the printing is resumed when the detected temperature is decreased to between-page cooling cancellation temperature.
US10189288B1	Rejected media unit storage for media processing devices A media processing device includes: a housing having an opening providing access to a cassette removably supported within the housing; a media unit holder configured to receive a rejected media unit driven between the opening and a body of the cassette along a media reject path; the media unit holder including: a deck having a support surface between a body of the cassette and the opening, the support surface facing the opening; the deck configured to receive the rejected media unit on the support surface for removal of the rejected media unit via the opening.
US10189285B2	Self-strip media module A self-strip media module in a printer is provided. The self-strip media module includes a peel bar having a length at least as great as the length of a platen roller and being rotatably engaged at the ends of the platen roller. The media includes a series of labels adhered to a liner. The media is fed over the peel bar and between the platen roller and a mid-chassis. The peel bar may be rotated towards the discharge side of the platen roller, pulling the media over the platen roller and over itself. A thermal print head is lowered onto the media over the platen roller and to print on the labels. The printer advances the media over the peel bar. The labels are stripped from the liner when the media advances around the peel bar.
US10189284B2	Tape cassette A tape cassette that includes a tape cassette that includes a housing having a top surface, a bottom surface, a rear wall, a front wall, and a tape feed exit located on the front wall, a tape included at least partially within the housing and configured to be fed along a tape feed path extending to the tape feed exit, and a first indicator aperture positioned on the front wall and a second indicator aperture position on a rear portion of the bottom surface. A position of the first indicator aperture on the front wall indicates a type of the tape included within the housing. A position of the second indicator aperture indicates a color of characters.
US10189282B2	Printer and computer-readable storage medium for executing multi-pass printing A printer performs a multi-pass printing including: (a) pass process executed with Ka number of nozzles; (c1) pass process executed with Kc1 number of nozzles; (c2) pass process executed with Kc2 number of nozzles; and (b) pass process executed with Kb number of nozzles. Kc1 and Kc2 are greater than or equal to Kb and smaller than Ka. An upstream gradient of dot recording rates of (c1) pass process is greater than a gradient of (a) pass process. A downstream gradient of (c1) pass process is the same as the gradient of (a) pass process. An upstream gradient of (c2)-pass process is the same as a gradient of (b) pass process. A downstream gradient of (c2)-pass process is greater than the gradient of the (a) pass process. Kc1 is greater than Kc2.
US10189280B2	Corrugated-board machine The invention relates to a corrugated-board machine for manufacturing corrugated board. The corrugated-board machine comprises a material-web output device for outputting a material web, an inkjet printing device disposed downstream of the material-web output device for the imprinting of at least one imprint onto the material web and an overcoating arrangement disposed downstream of the inkjet printing device for overcoating the printed material web at least in regions.
US10189277B2	Device and method for pretreating and printing textile surfaces The invention relates to an apparatus and a method for pretreating and printing textile surfaces. For this purpose, at least one pallet (22) for accommodating and retaining a textile article (20) to be printed on a printing face, a pretreatment device (40) which allows the textile article to be pretreated, prior to it being printed, by applying a pretreatment fluid to the textile article in a pretreatment area, a printing device (60) comprising at least one printhead (61) that allows a printed image to be printed onto the textile article in the pretreatment area, a moving device (23) which allows the at least one pallet to he displaced relative to the pretreatment device and the printing device, and a programmable control device (31) which allows the printing device, the pretreatment device and/or the moving device to be controlled, are provided. An identification device (30) which can identify the textile article and is connected to the programmable control device is provided in front of the pretreatment device, and depending on the identified textile article, the pretreatment area can be applied individually to a subarea of the printing dace of the textile article.
US10189274B2	Printer, and method and computer-readable medium for the same A printer includes a controller configured to, while conveying a print medium, apply a fourth quantity of thermal energy per unit area to a first area of the print medium and apply a fifth quantity of thermal energy per unit area to a second area that at least partially overlaps the first area in a conveyance direction, the print medium developing a color when supplied with a quantity of thermal energy per unit area equal to or more than a first quantity and equal to or less than a second quantity and developing another color when supplied with a quantity of thermal energy per unit area equal to or more than a third quantity more than the second quantity, the fourth and fifth quantities being more than the first quantity and less than the second quantity, a sum of the fourth and fifth quantities being less than the third quantity.
US10189269B2	Recording apparatus and recording method A recording apparatus discharges both high-permeability black ink and low-permeability black ink to a boundary between a color area and a black area.
US10189268B2	Solvent or ink container plug A solvent or ink container plug includes a cylindrical base having an upper side and a lower side, the lower side being configured to face an inside of a container when the container is closed by the plug. The plug further includes a connection portion, connected to the upper side of the cylindrical base, the connection portion comprising at least two connection tips. The cylindrical base includes a first aperture and a second aperture provided at the lower side of the cylindrical base. Moreover, the first aperture and second aperture are each in communication with a corresponding one of the two connection tips. Further, the connecting portion has a side dimension, measured in a plane perpendicular to an axis of introducing the plug onto or into the container, that is smaller than the cylindrical base.
US10189265B2	Printing fluid cartridge In some examples, printing fluid cartridge comprises a housing and an assembly supported by the housing. The assembly comprises a molding and a non-fluid dispensing die electronic device embedded in the molding.
US10189259B2	Joining method, apparatus of manufacturing joined body, joined body, ink jet head unit, and ink jet type recording apparatus A joining method includes a process of applying a joining material including a thermosetting resin to a member. The joining material includes an addition-type silicone resin. The joining material includes one or more kinds selected from the group consisting of a methyl-based straight silicone resin, a phenyl-based silicone resin, and a modified silicone resin.
US10189256B2	Liquid ejecting apparatus A liquid ejecting apparatus includes a head that ejects an ink while moving in an X direction, a plurality of liquid retention portions that are arranged in a direction that intersects the X direction and retain the ink, a mounting portion in which the plurality of liquid retention portions are mounted, and a plurality of flow channels that are provided in the mounting portion and supply the ink to the head from the plurality of liquid retention portions, in which the plurality of liquid retention portions include a liquid retention portion that retains a black ink, and, among flow channel lengths of the plurality of flow channels, the flow channel length of a flow channel that supplies the black ink is shortest.
US10189253B2	Liquid ejection head and method for producing the same A liquid ejection head includes a substrate; and an ejection orifice-forming member formed on the substrate and including an ejection orifice configured to eject liquid and a liquid channel communicating with the ejection orifice. The ejection orifice-forming member includes an ejection orifice-forming member layer A, an intermediate water-repellent layer, and an ejection orifice-forming member layer B in this order from a substrate-side of the member. The ejection orifice-forming member also includes a protrusion protruding into the ejection orifice, and the ejection orifice-forming member includes a water-repellent projection portion that is at least a portion of the intermediate water-repellent layer and that projects farther into the ejection orifice than the ejection orifice-forming member layer A and the ejection orifice-forming member layer B.
US10189252B2	Methods, systems, and apparatuses for improving drop velocity uniformity, drop mass uniformity, and drop formation Methods and systems are described herein for driving droplet ejection devices with multi-level waveforms. In one embodiment, a method for driving droplet ejection devices includes applying a multi-level waveform to the droplet ejection devices. The multi-level waveform includes a first section having at least one compensating edge and a second section having at least one drive pulse. The compensating edge has a compensating effect on systematic variation in droplet velocity or droplet mass across the droplet ejection devices. In another embodiment, the compensating edge has a compensating effect on cross-talk between the droplet ejection devices.
US10189250B2	Printhead, element substrate, and printing apparatus A printhead, comprises: a plurality of element substrates that each include a first element substrate adjacent to a second element substrate in a first direction, wherein a first print element array arranged in the first element substrate includes a first print element that is closest to the second element substrate in the first direction, and a second print element array arranged in the second element substrate includes a second print element closest to the first element substrate in the first direction, and an order of arrangement in the second direction of at least the first print element and a first driving circuit corresponding to the first print element is opposite to an order of arrangement in the second direction of the second print element and a second driving circuit corresponding to the second print element.
US10189243B2	Printing transferable components using microstructured elastomeric surfaces with pressure modulated reversible adhesion In a method of printing a transferable component, a stamp including an elastomeric post having three-dimensional relief features protruding from a surface thereof is pressed against a component on a donor substrate with a first pressure that is sufficient to mechanically deform the relief features and a region of the post between the relief features to contact the component over a first contact area. The stamp is retracted from the donor substrate such that the component is adhered to the stamp. The stamp including the component adhered thereto is pressed against a receiving substrate with a second pressure that is less than the first pressure to contact the component over a second contact area that is smaller than the first contact area. The stamp is then retracted from the receiving substrate to delaminate the component from the stamp and print the component onto the receiving substrate. Related apparatus and stamps are also discussed.
US10189242B2	Methods for additively manufacturing composite parts A method of additively manufacturing a composite part is disclosed. The method comprises depositing a segment of a continuous flexible line along a print path. The continuous flexible line comprises a non-resin component and a thermosetting resin component that is not fully cured. The method further comprises, while advancing the continuous flexible line toward the print path, delivering a predetermined or actively determined amount of curing energy at least to a portion of the segment of the continuous flexible line at a controlled rate after the segment of the continuous flexible line is deposited along the print path to at least partially cure at least the portion of the segment of the continuous flexible line.
US10189241B2	Methods for additively manufacturing composite parts A method of additively manufacturing a composite part is disclosed. The method comprises pushing a continuous flexible line through a delivery guide. The continuous flexible line comprises a non-resin component and a thermosetting-epoxy-resin component that is partially cured. The method also comprises depositing, via the delivery guide, a segment of the continuous flexible line along a print path. The method further comprises maintaining the thermosetting-epoxy-resin component of at least the continuous flexible line being pushed through the delivery guide below a threshold temperature prior to depositing the segment of the continuous flexible line along the print path.
US10189237B1	Feedstock lines for additive manufacturing of an object A feedstock line comprises elongate filaments, a resin, and optical direction modifiers. The resin covers the elongate filaments. The optical direction modifiers are covered by the resin and are interspersed among the elongate filaments. Each of the optical direction modifiers has an outer surface. Each of the optical direction modifiers is configured such that when electromagnetic radiation strikes the outer surface from a first direction, at least a portion of the electromagnetic radiation departs the outer surface in a second direction that is at an angle to the first direction to irradiate, in the interior volume of the feedstock line, the resin that, due at least in part to the elongate filaments, is not directly accessible to the electromagnetic radiation, incident on the exterior surface of the feedstock line.
US10189231B2	Fabric having a waterproof barrier Provided herein are ecologically friendly waterproof fabrics that include a base fabric having a body-facing surface and an outward-facing surface, and a hydrophobic, waterproof barrier disposed on the outward-facing surface of the base fabric. The base fabric may be a wicking fabric or may be treated with a compound that enhances wicking, and the hydrophobic, waterproof barrier may include a plastic polymer, polyurethane, polyethylene, and/or polytetrafluoroethylene. The waterproof fabrics also may include an abrasion-resistant coating and/or a PFC-free durable water repellant (DWR) agent disposed on an outward-facing surface of the hydrophobic, waterproof barrier, and one or both of the abrasion-resistant coating and/or PFC-free DWR agent may be discontinuous. Also provided are methods of making a waterproof fabric.
US10189229B2	Surface-treated steel sheet A surface-treated steel sheet of the present invention includes: a base steel sheet; a surface treatment layer which is formed on at least one surface of the base steel sheet and includes an oxide layer and a metal layer; and a chemical conversion layer which is formed on a surface of the surface treatment layer. The surface treatment layer contains Zn in an adhered amount of 0.30 g/m2 to 2.00 g/m2 and Ni in an adhered amount of 0.03 g/m2 to 2.00 g/m2, which is equal to or lower than the adhered amount of Zn. In a case of performing a glow discharge spectrometry, at an interface between the oxide layer and the metal layer, an emission intensity of Fe atoms is 20% or less of the maximum emission intensity of the Fe atoms, and the emission intensity of Ni atoms is 20% or less of the maximum emission intensity of the Ni atoms. In addition, a first range in which the emission intensity of Zn atoms is 60% or higher of the maximum emission intensity of the Zn atoms and a second range in which the emission intensity of the Ni atoms is 60% or higher of the maximum emission intensity of the Ni atoms overlap.
US10189227B2	Tailored panel assembly and method of manufacturing the same A panel assembly is formed by a plurality of bonds between two sheet materials in a face to face relationship to form a preform. The plurality of bonds define a closed perimeter region between the two sheet materials and an open perimeter region between the two sheet materials. The preform may be formed into a predefined shape. Pressurized fluid is applied through an inlet into the open perimeter region to expand the preform. The pressurized fluid expands the open perimeter region such that the two sheet materials expand in an opposing direction, thereby defining an expanded open perimeter region. The closed perimeter region between the two sheet materials remains vacant of the pressurized fluid such that the closed perimeter region is not expanded. The expanded open perimeter region is filled with a filler material for improving a performance characteristic of the panel assembly, e.g., strength, sound absorption, or stiffness.
US10189225B2	Hose with optimized steel wire reinforcement layers A high pressure hose having steel wires with different load elongation properties, which are introduced into the subsequent reinforcement layers of the hose. The difference in load elongation is quantified by the E-ratio of the wire that is equal to the tensile strength divided by the elongation at break. The steel wires of the radially outermost steel wire reinforcement layer have the highest E-ratio, while the radially innermost steel wire reinforcement layer has the lowest E-ratio. The E-ratio of any steel wire reinforcement layer is not lower than the E-ratio of any inner laying steel wire reinforcement layer. The E-ratio of the steel wires can be influenced by either a thermal treatment or by a mechanical treatment. In the mechanical treatment crimps or bends can be introduced into the wire by guiding them through a preforming device.
US10189224B2	Methods for making rubber bales Methods for forming improved bales may include using baling equipment with multi-component bolster assemblies that may ease installation and removal, reduce wear and tear and maintenance, and/or improve efficiency by reducing material waste, imperfections, and/or contamination. The bolster assemblies may include a plurality of coupling portions that engage a hydraulic rod and may enable the bolster assembly to self-center within a press chamber during normal baling operations. The bolster assemblies also may include an island portion that may be attached to the coupling portions and to a bolster cap, and the latter may be attached using retainer bolts having substantially planar heads that may define lips that run about frustums. The bolts may substantially planar head may reduce irregularities in the bale and the lips may prevent material seepage into the bolster assemblies.
US10189220B2	Calculation system for manufacturing an ophthalmic lens A calculation system (1) for manufacturing an ophthalmic lens. A set of calculation modules (M1, M2, M3, M4) is associated to partial calculation in relation with manufacturing process of said ophthalmic lens. A managing unit (MU) is configured to: receive input data, and calculate output data through one or several iteration(s) of: determining one or several calculation module(s) to be activated, determining an order of activation of the one or several calculation module(s), and activating the determined one or several calculation module(s), in accordance with the determined order of activation. The managing unit transmits an indication that the output data have been calculated.
US10189219B2	Method of fabricating a ceramic article A disclosed resin transfer molding process includes inserting a ceramic article within a bladder defining a part cavity, inserting the bladder including the ceramic article into a second cavity with a fixed geometry, and pressurizing the bladder against the ceramic article. The method further includes injecting resin into the ceramic article within the bladder with the bladder against the ceramic article to maintain resin within the ceramic article during curing.
US10189217B2	Method for preparing thermoplastic prepreg and thermoplastic prepreg prepared thereby A method for preparing a high quality thermoplastic prepreg, includes: laminating a thermoplastic resin film having a crystallization degree in a range of 1 to 20% on at least one surface of a matrix fiber; and heating the laminate to a higher temperature than a melting point of the film, then, pressing the same. The method uniformly impregnates a matrix fiber with a thermoplastic resin, has a short curing cycle in the formation, and involves no random modification in alignment of fibers in the matrix fiber due to a low crystallization degree of the impregnated thermoplastic resin, thereby increasing rigidity of a formed product and enabling reduction of thickness. Thus produced prepreg has a low weight variation per unit area.
US10189213B2	Method and manufacturing unit for producing fiber composite material components In a method and apparatus for producing fiber composite material components, a first web of the fiber composite material is applied to a mold by means of an application tool arranged on a positioning device. A height profile of the applied first web is measured by means of a height profile measuring sensor. During the application of a second web of the fiber composite material to the mold, a control device activates at least one drive motor of the positioning device depending on the measured height profile, so that application errors, such as overlapping of the webs, are avoided. The webs are applied in opposite application directions by rotating the application tool 180° relative to the positioning device upon a change in the application direction. Two height profile measuring sensors arranged next to one another on the application tool for measuring the height profile of the applied webs.
US10189205B1	Printer head z-axis alignment method and system A 3D printer calibration system and method includes a controller controlling movement of the 3D printer printhead in a first axis, such as the z-axis. The printhead includes a hotend for depositing material to generate the 3D printing. The hotend is connected to the printhead via a connector being moveable along the first axis. The hotend further includes an arm that extends outward from the side of the hotend. An optical sensor assembly is affixed to the printhead, the optical sensor assembly that has a light emitter and a light detector. The controller calibrates a starting position for the printhead based on the first axis deflection of the hotend as detected by the optical sensor assembly. The connector allowing first axis deflection of the hotend distinct from the first axis movement of the printhead.
US10189203B2	Method for forming micropattern of polyimide using imprinting Provided is a method for forming a pattern of polyimide that is simpler and is more excellent in the pattern shape and in the dimensional accuracy in comparison with the conventional techniques of patterning polyimide, such as photolithography and laser processing. In a method for forming a micropattern of polyimide, which includes using as polyimide a solvent-soluble polyimide resin composition that is photosensitive and is moldable at a temperature of less than or equal to a glass-transition temperature; patterning the composition using thermal imprinting; and thermally curing the composition, ultraviolet irradiation is performed after the composition is released from a mold after a molding step.
US10189199B2	Highly modified polyesters for containers A polyester resin for use in a process in which, during an expansion step, an incompressible fluid is injected through an opening of a preform, formed of the polyester resin, to form a container. The polyester resin includes a crystallizable polyester polymer wherein the polyester polymer is comprised of acid moieties and glycol moieties, with at least 85% of the total moles of acid moieties being terephthalate derived from terephthalic acid or its dimethyl ester and at least 85% of the total moles of glycol moieties derived from ethylene glycol. At least 2% of the total moles of acid plus glycol moieties are derived from a primary comonomer with the mole percents of the acid plus glycol moieties totaling 100 mole %.
US10189193B2	Method for the production of a fluid container for a motor vehicle, and corresponding fluid container In a method of producing a fluid container for a motor vehicle, at least one of at least two shells is injection-molded in a mold with a sidewall and a plurality of projections in spaced-apart relation to one another and to the sidewall. The plurality of projections is hereby injection-molded off-tool. The at least two shells are connected to form the fluid container.
US10189191B2	Collection of process data using in-situ sensors A system is provided for collecting data during vacuum molding of a composite part using a mold including an air tight, flexible membrane sealed to a tool. The system comprises a plurality of MEMS sensors coupled with the interior of the mold at different locations over the part. Each of the sensors produces signals related to a process parameter, such as pressure within the bag, that is sensed at the location of the sensor.
US10189187B2	Methods and apparatus for computer-assisted spray foam fabrication In exemplary implementations of this invention, a nozzle sprays foam, layer by layer, to fabricate a fabricated object according to a CAD model, and a subtractive fabrication tool removes material from the fabricated object according to a CAD model. The fabricated object comprises a mold or an interior form. The foam may be low-density, high strength and fast-curing. The foam may be used for large-scale 3D printing. For example, the foam may be used to 3D print molds for walls of homes. The foam molds may be left in place, after casting concrete in the molds, to serve as insulation. Or for example, the foam may be used to 3D print on site an internal form for a large wind turbine blade. The wind turbine blade may then be produced on site by depositing fiberglass on the outside of the internal form.
US10189178B2	Method for producing wood material panels, in particular OSB wood material panels, and wood material panel that can be produced in accordance with said method A method of producing wood-base panels, especially OSB wood-base panels is provided. The method including the steps of providing wood strands, applying at least one adhesive system to the wood strands having at least one polymer adhesive and at least one nanoparticle below 500 nm, and pressing the wood strands admixed with the adhesive system to form wood-base panels.
US10189177B2	Engineered timber products, components and methodologies A method of drying sticks, a related apparatus, resultant product and its uses where the method involves presenting a plurality of sticks in parallel as a single layer, pressing each stick with a bank of pressing members on and/or into at least one face of the sticks, each with plurality of protuberances, thereby to constrain the sticks against crook, and drying the sticks when so constrained. Preferably each bank of pressing members is an underside of a frame or lattice of a stack of such frames or lattices able to receive such a single layer of sticks between adjacent overlying/underlying frames or lattices, the protuberances preferably being only downwardly directed.
US10189173B1	Pneumatic tool A pneumatic tool has a hollowed main body. One end of the main body is assembled with a pneumatic motor having a transmission shaft inserted into the main body. The other end of the main body is assembled with a connecting member being slidable along an axial direction of the main body. One end of the connecting member forms a connecting portion, and the other end of the connecting member forms a knife assembling portion. A driving gear is rotatably assembled in the main body and engaged with the transmission shaft. A protruding post is assembled on a portion of the driving gear biasing from an axis of the driving gear. A linking bar has a first end and a second end opposite to the first end. The first end is pin-jointed to the protruding post, and the second end is pin-jointed to the connecting portion of the connecting member.
US10189172B2	Method of reusing remnant prepreg framework The present invention provides a method of reusing prepreg material. The method comprises providing a remnant prepreg, defining a pattern of cutting the remnant prepreg framework to form a continuous strip of the remnant prepreg framework, and cutting the remnant prepreg framework to form a continuous strip of the remnant prepreg framework. The remnant prepreg framework continuous strip may be extruded into a short fiber molding compound (SMC). The SMC may then be used to make parts with lower structural requirements than the parts cut out of the prepreg broadgood. Such SMC parts may be used in industries such as aerospace; automotive; other transportation such as trucks, buses, and motorcycles; sporting goods; and wind.
US10189170B2	Locking folding knife A locking folding knife includes a handle and a blade pivotally connected to the handle. The blade has a cutting edge and a first position in which at least a portion of the cutting edge is located within the handle and a second position in which a majority of the cutting edge is outside of the handle. A pocket is defined in a first surface of the handle. A through-cut is in the pocket, wherein the through-cut terminates in the pocket at an endpoint. A lock is integral with the handle and extends from the endpoint of the through-cut, wherein the lock engages with a portion of the blade in the second position.
US10189168B2	Soft robotic actuator enhancements Exemplary embodiments provide enhancements for soft robotic actuators. In some embodiments, angular adjustment systems are provided for varying an angle between an actuator and the hub, or between two actuators. The angular adjustment system may also be used to vary a relative distance or spacing between actuators. According to further embodiments, rigidizing layers are provided for reinforcing one or more portions of an actuator at one or more locations of relatively high strain. According to further embodiments, force amplification structures are provided for increasing an amount of force applied by an actuator to a target. The force amplification structures may serve to shorten the length of the actuator that is subject to bending upon inflation. According to still further embodiments, gripping pads are provided for customizing an actuator's gripping profile to better conform to the surfaces of items to be gripped.
US10189167B2	Suction device, holding device, and conveyance method A suction device is attached to a leading-end section of an articulated arm, attached by suction to a plate-shaped structural member having a curvature at least in a predetermined direction. The suction device includes a support part attached to the leading-end section of the articulated arm; a pair of suction mechanisms having a pair of suction surfaces and disposed apart from each other in an X direction with the attachment position of the support part to the leading-end section interposed between the pair of suction mechanisms; and a pair of first angle adjustment mechanisms capable of adjusting the angle of inclination, in the X direction, of each of the pair of suction surfaces of the pair of the suction mechanisms.
US10189165B2	Actuators with conforming sleeves An actuator includes at least one actuator body and a sleeve covering a portion of the actuator body. The actuator body comprises a first material, and the sleeve comprises a second material that is more rigid than the first material. The sleeve constrains bending of the actuator body where the sleeve covers the actuator body.
US10189164B2	Robot, control device, and robot system A robot includes n arms, n drive units that respectively drive the n arms, n position detecting units that respectively detect positions of the n arms, and L signal lines through which signals detected by the n position detecting units flow. When the number of control units that control the driving of the drive units based on the signals detected by the position detecting units is m, the robot satisfies the relations of 2≤L
US10189162B2	Model generation apparatus, information processing apparatus, model generation method, and information processing method A three-dimensional shape model of a target object is input. A position and orientation of at least one image sensing device used to capture an image of the target object is set so as to virtually set a relative position and orientation between the target object and the image sensing device for the three-dimensional shape model of the target object. At least one position and orientation of the image sensing device is selected. Geometric features are grouped based on a relationship between an image to be obtained at the selected position and orientation of the image sensing device and the geometric features of the three-dimensional shape model.
US10189161B2	Calibration system and calibration method calibrating mechanical parameters of wrist part of robot A calibration system able to calibrate mechanical parameters of a wrist part by a simpler manner is provided. The calibration system utilizes a target fastened at a predetermined position with respect to the joint closest to a hand of a robot and an imaging device set around the robot so as to calibrate the parameters of a mechanical model representing the wrist part of the robot. The posture of the target is changed from a predetermined initial position to generate a plurality of preliminary positions. Using these preliminary positions as starting points, the end point position of the robot whereby the target becomes a predetermined positional relationship with respect to the imaging device on the image obtained by capturing an image of the target is calculated. The calibration system uses the calculated end point position as the basis to calibrate the mechanical parameters of the wrist part.
US10189160B2	Systems and methods for automatically inserting components into an electrical connector Automated assembly systems and methods are configured to automatically insert components into grommets. The systems include a component insertion sub-system configured to insert first components into first cavities of a first grommet, an imaging sub-system configured to acquire images of the first grommet, and a grommet shift determination sub-system in communication with the component insertion sub-system and the imaging sub-system. The grommet shift determination sub-system is configured to compare at least two images of the first grommet acquired by the imaging sub-system to determine distance changes between the first cavities in response to one or more of the first components being inserted into one or more of the first cavities, and generate an insertion map that accounts for the distance changes.
US10189153B2	Leveling device assembly for a hydraulic hammer A leveling device assembly for use with a hydraulic hammer is provided. The leveling device assembly comprises a control unit, a leveling sensor in communication with the control unit, and a laser generator in communication with the control unit. Additionally, the laser generator is configured to produce a first colored light beam and a second colored light beam different from the first colored light beam. The control unit is further configured to cause the laser generator to produce the first colored light beam when the leveling sensor indicates the hydraulic hammer is in a substantially vertical position and produce the second colored light beam when the leveling sensor indicates the hydraulic hammer is in a substantially non-vertical position.
US10189151B2	Compact head body hammer A compact head body hammer that requires less clearance to operate as compared to conventional hammers. The hammer does not include a secondary tool located on the rear of the hammer, for example, a pry or a wedge. In omitting these secondary tools, the hammer provides more clearance and allows greater pull back prior to the user striking an object. Further, the hammer head can weigh substantially the same as a conventional hammer head, for example, seven ounces, so that the striking power of the hammer is not compromised by the compact nature of the hammer. The centerline of the hammer head base can be offset with respect to a centerline of the hammer handle, which also provides less mass at the rear portion of the hammer head and allows greater pull back prior to striking the object.
US10189149B2	Retention apparatus for portions of adjustable wrench The present disclosure is directed to an apparatus for use with an adjustable wrench to limit the displacement of a broken portion of the adjustable wrench relative to the remaining parts of the adjustable wrench when the wrench fractures.
US10189146B2	Abrasive tools and methods for forming same An abrasive tool can include a bonded abrasive including a body and a barrier layer bonded to a major surface of the body. The body can include abrasive particles contained within a bond material. The barrier material can include a metal-containing film. In an embodiment, the barrier layer may further include a polymer-containing film. In another embodiment, the barrier layer may include a biaxially oriented material. The abrasive tool may be formed such that the barrier layer is formed in-situ with the formation of the bonded abrasive.
US10189140B2	Hand-held machine tool having an electronically commutated electric motor as direct drive A hand-held machine tool has an electric-motor drive and a machining tool. The electric-motor drive has an electronically commutated electric motor, and the electric-motor drive is provided to drive the machining tool. The electronically commutated electric motor has an outer diameter, and a ratio of the outer diameter of the electronically commutated electric motor to a diameter of the machining tool is a maximum of 0.42.
US10189134B2	Indexable plenum An indexable plenum and a method of using the plenum to collect dust and/or debris during a cutting or milling process are disclosed. The plenum, when attached to the spindle nose of a conventional machine, enables the conventional machine that does not have a hollow spindle nose to be used with a hollow or conventional solid cutter to remove dust and/or debris generated during the cutting process. The indexable plenum comprises a hollow body and a base plate. Hollow bodies of different shape and size that are able to fit differently shaped and sized cutters are disclosed. The hollow bodies can be designed to releasably engage with the same base plate such that when the base plate is attached to the machine spindle nose, hollow bodies can be exchanged during a milling or cutting process to accommodate correspondingly shaped/sized cutters. In various embodiments, the object that is cut or milled is low density foam.
US10189130B2	Machine tool A tool holding part holds two boring bars in a manner in which axes of the boring bars are parallel to a spindle axis. A tool change mechanism has a circular arc movement mechanism in which the boring bar moves from a tool holding position to a tool change position by at least a circular arc movement on a plane surface including an axis of the spindle in the tool change position and an axis of the boring bar positioned in the tool holding part.
US10189127B2	Positioning of a spindle with micrometric forwarding control and tilting of its rotation axis A positioning of a spindle with micrometric forwarding control and tilting of its rotation axis includes a spindle shaft rotatingly supported inside rotatable supports, wherein the rotatable supports include two spherical elements having housings which are eccentric with respect to the rotation axis that join the centers of the spheres, and wherein the two spherical elements are positioned in a cylindrical housing having at least two parts, and wherein two rotation elements are connected to the two spherical elements and cause their independent rotation.
US10189125B2	Assembly inspection method and associated device A method for inspecting the quality of an alignment between the elements of an assembly, and an associated device, the method of which comprises tasks consisting of measuring a first parameter with a first measuring means, said first parameter being selected from a movement parameter of at least one part of the double-access fastening means, an assembly force parameter or a torque, measuring a second parameter with a second measuring means, said second parameter being selected from the same parameters and being different from the first parameter, calculating a value of a first derivative of a function representing a change in the second parameter relative to the first parameter by suitable information processing means, and analyzing the value of the first derivative to check the alignment between the elements to be assembled.
US10189124B2	Assembling device of wheel hub unit An assembling device including: a bearing setting unit configured to set a bearing unit such that the bearing unit is coaxial with respect to a hub cylindrical part and can be moved toward the hub cylindrical part, a rotational drive source configured to transmit rotational force around an axis to the bearing unit set in the bearing setting unit; and an inner-ring press-fitting unit configured to externally fit inner rings of the bearing unit to which the rotational force around the axis has been transmitted, to the hub cylindrical part.
US10189122B1	Torch guide device A torch guide assembly for cutting target material is presented, the torch guide assembly including a cradle assembly coupled to a rail assembly. The cradle assembly is configured for holding a torch to align a torch tip of the torch to the target material. The cradle assembly is movable along the rail assembly for cutting the target material along a cutting path. A connector member couples the cradle assembly to the rail assembly. The connector member comprises a pivot for pivoting the cradle assembly relative to the rail assembly. The cradle assembly, in a first position, pivots about the pivot to engage at least a portion of the rail assembly to establish an orientation of the torch tip relative to the target material. A magnetic clamp assembly comprises a mechanical device for releasing the clamp.
US10189121B2	Organic acid-or latent organic acid-functionalized polymer-coated metal powders for solder pastes The present invention relates to organic acid- or latent organic acid-functionalized polymer-coated metal powders, such as metal powders used as appropriate in the formation of solder alloys, spheres and pastes.
US10189120B2	Welding wire for Fe—36Ni alloy The invention concerns a welding wire intended for use in welding together parts of parts consisting of F3-36Ni alloy. The welding wire consists of an alloy comprising, in wt. %: 38.6%≤Ni+Co≤45.0% trace≤Co≤0.50% 2.25%≤Ti+Nb≤0.8667×(Ni+Co)−31.20% if 38.6%≤Ni+Co≤40.33% 2.25%≤Ti+Nb≤3.75% if 40.33%≤Ni+Co≤41.4% 0.4167×(Ni+Co)−15.0%≤Ti+Nb≤3.75% if 41.4%≤Ni+Co≤45.0% trace≤Nb≤0.50% 0.01%≤Mn≤0.30% 0.01%≤Si≤0.25% trace≤C≤0.05% trace≤Cr≤0.50% the rest consisting of iron and inevitable impurities resulting from production.
US10189115B2	Laser processing apparatus and laser processing method Provided is a laser processing apparatus provided with: a first optical system including a first prism and a second prism; a second optical system including a third prism and a fourth prism; a condensing optical system that condenses laser light to guide the condensed laser light to a workpiece; a first driving device that rotates the first prism and rotates the second prism synchronously with the first prism; a second driving device that rotates the third prism and rotates the fourth prism synchronously with the third prism; and a controller that controls the first driving device and the second driving device such that the workpiece is irradiated with the laser light while the laser light turns. The controller adjusts irradiation conditions of the laser light including an incidence position and an incidence angle of the laser light with respect to the workpiece, by adjusting a relative position between the first prism and the second prism and a relative position between the third prism and the fourth prism in a rotational direction.
US10189113B2	Resistance spot welding method A resistance spot welding method can be used to join polymeric and metallic workpieces together and includes the following steps: (a) placing an electrically conductive coating between a polymeric workpiece and a metallic workpiece, wherein the metallic workpiece has a textured surface facing the polymeric workpiece; (b) piercing the polymeric workpiece with first and second electrically conductive pins of a welding electrode assembly; (c) applying electrical energy to the first and second electrically conductive pins so that an electrical current flows through the first electrically conductive pin, the electrically conductive coating, and the second electrically conductive pin in order to at least partially melt the polymeric workpiece and the electrically conductive coating, thereby forming a weld pool; and (d) cooling the weld pool to form a solid weld nugget in order to establish a mechanical interface lock between the solid weld nugget and the textured surface.
US10189109B2	Purge dam and method of use A purge dam assembly confines a volume within an assembly of pipes, including a distal pipe and a proximal pipe together arranged for butt welding at a seam. A distal disk is covered at its periphery with a distal sock including gasketing material. A proximal disk is covered at its periphery with a proximal sock including the gasketing material. Each disk is sized such that the sock contacts but does not completely seal against an inner surface of one of the tubes or pipes permitting a purging flow of gas from the volume and past each disk. A cross-member having a proximal and a distal end, the proximal end is affixed to the proximal disk and the distal end is affixed to the distal disk to preserve the spatial separation between the proximal disk and distal disks and to maintain the proximal and distal disks in coaxial alignment.
US10189108B2	Hot-wire welding assembly for deep and narrow recessed gaps A contact tip for hot-wire welder is provided that are adapted to operate in deep and narrow recessed gaps within a work piece. Contact tips in accordance with the current invention provide for an assembly having a body portion with a cavity and an extension portion which is inserted into the cavity. The extension portion is non-electrically conductive and allows the contact tip assembly to reach into deep, narrow grooves without worry of shorting the contact tip of the consumable.
US10189106B2	Reduced energy welding system and method A welding regime may implements cyclic short circuits under a closed loop voltage control approach. Upon clearing or imminent clearing of the short circuit, a current recess is implemented. The current recess reduces the current that would otherwise be applied to the weld, resulting in multiple benefits. The recess may be implemented by suspending voltage command signals. Following the current recess, normal control is resumed with the then-current voltage command.
US10189103B2	Wire electrical discharge machining apparatus A wire electrical discharge machining apparatus capable of improving the shape precision of a continuous corner part includes a corner speed coefficient calculation device calculating a machining speed ratio between a middle corner section and a straight part from a machining volume ratio between the straight part and the middle corner section in which machining volume becomes a constant value. A corner speed coefficient interpolation device interpolates a speed coefficient calculated by the corner speed coefficient calculation device in a pre-corner section and a post-corner section. A speed reference calculation device calculates a machining speed reference based on a representative speed and the corner speed coefficient, and a drive control device controls a drive device. A continuous corner detection device determines whether continuous corner sections overlap each other when the length of the straight part connecting two corner parts is shorter than the length of the pre-corner section.
US10189098B2	Diagnostic and maintenance operation for a saw A method for measuring brush wear in a motor of a saw includes generating, with a sensor connected to a brush in a motor of the saw, a first signal corresponding to a level of wear in the brush and identifying, with a controller, a level of wear for the brush with reference to the first signal. The method further includes generating, with the controller and a user interface device, an output requesting replacement of the brush in response to the identified level of wear exceeding a predetermined threshold.
US10189096B2	Crankshaft machining system and crankshaft machining method A crankshaft machining system includes a center hole boring device, a post-centering balance meter and a cutting device. The post-centering balance meter is configured to measure the shape of a post-centering crankshaft blank on the basis of a pair of center holes. Additionally, the post-centering balance meter is configured to set a principal axis of inertia on the basis of the shape of the post-centering crankshaft blank and generate center hole positional information for correction that indicates intersections between the principal axis of inertia and both end surfaces of the post-centering crankshaft blank. The center hole boring device is configured to bore a pair of center holes on both end surfaces of another crankshaft blank to be loaded next on the basis of the center hole positional information for correction.
US10189090B2	Drilling tool A drilling tool with: a shaft; a seat at one end of the shaft; a drill bit, which is arranged on the seat; and a clamping section, which is provided on the shaft and can interact with the drill bit. Also provided is a tensioning screw, which is screwed into the shaft and comprises an expanding section as well as a contact section. The expanding section interacts with the clamping section, and the contact section interacts with the drill bit.
US10189088B2	Tubular connection refacing apparatus and methods An apparatus and method of using an apparatus for refacing a tubular connection is provided. In one example, the apparatus has a mandrel connectable to a threaded portion of a tubular connection and two face plates bearing cutters for refacing surfaces of the tubular connection. In this example, the cutting is controlled by an engaging nut moving along a threaded portion of a drive shaft, and the two face plates may be spaced apart at a fixed distance to maintain the distance between the torque-stop surface and the primary surface after refacing. Also, the apparatus uses a locking pin to assist in tightening or loosening the mandrel into place using the remainder of the apparatus. An air-oil system is provided to supply air and oil to the cutting surfaces as the apparatus refaces the shoulders of the connection. An exemplary pin refacer and an exemplary box refacer are both disclosed.
US10189087B2	Methods of making parts from at least one elemental metal powder One aspect of the disclosure relates to a method of making a part from at least one elemental metal powder. The part has a near-net shape, a part volume, and a part density. The method includes providing a sintered preform having a sintered density and separating a portion from the sintered preform. The portion has a portion volume exceeding the part volume and a portion shape different from the near-net shape of the part. The method also includes thermally cycling the portion for a thermal-cycling time period at a thermal-cycling pressure while superplastically deforming the portion to form the part having the near net shape and the part density.
US10189086B2	Method and apparatus for manufacturing porous three-dimensional articles Disclosed is a method for manufacturing three-dimensional articles with porosity. A model is created of a porous structure, said creating step comprising the steps of: defining a three-dimensional space comprising a predetermined pattern of nodes, wherein said nodes are connected together in a predetermined manner with struts, moving each node in said three-dimensional space a randomized distance, which distance is less than a predetermined value and in a randomized direction, slicing said three-dimensional space into a predetermined number of two-dimensional layers with a predetermined thickness, slicing said three-dimensional article into two-dimensional layers with a predetermined thickness, applying one two-dimensional layer of said article on one two-dimensional layer of said porous structure resulting in a porous two-dimensional layer of said article, repeating said applying step for all two dimensional layers of said article, manufacturing the three-dimensional article with porosity according to the model by exposing fusible material to an energy source.
US10189084B2	Method and system for fabrication of hydrogen-permeable membranes A method for fabrication of an hydrogen-permeable membrane, comprising forming an alloy of a target composition and structure from powders by mechanically alloying; and forming a membrane from the alloy of the target composition and structure.
US10189076B2	Methods and apparatus for actuated fabricator In exemplary implementations of this invention, an actuated fabricator deposits structural elements (e.g., tensile structural elements) in a 3D pattern over large displacements. The fabricator is supported by at least three elongated support members. It includes onboard actuators that translate the fabricator relative to the ends of the support members. The fabricator is configured, by actuating different translations along different support members, to translate itself throughout a 3D volume. In some implementations, each of the actuators use fusible material to fuse metal tapes together, edge-to-edge, to form a hollow structure that can be shortened or lengthened.
US10189073B2	Matrix for making clinch-type joints between sheet-formed members and an apparatus including such a matrix A matrix for making clinch-type joints between at least two members of sheet-formed material of the same or different types. Said matrix (1) has the form of a thin plate, and comprises two generally flat sheet-formed matrix elements (2, 3, 2′, 3′, 102, 103) arranged movable relative to each other so that they could slide on an essentially flat support surface (31, 34, 134) in a substantially translational or pivotal movement between a first initial position in which said matrix elements (2, 3, 2′, 3′, 102, 103) form between them at least one essentially closed matrix cavity (23, 23′, 123) and a second position corresponding to an open position for said at least one matrix cavity, said matrix elements (2, 3, 2′, 3′, 102, 103) being arranged actuated in the direction of said first position by at least one actuation means (4, 10, 104). An apparatus including such a matrix is also proposed.
US10189070B2	Roller for roll forming A roller for engaging an outer surface of a pipe element during roll forming has a perimeter region defined by three faces. A channel is positioned in one of the faces. The channel extends circumferentially around the perimeter region and provides a void space that reduces the contact area between the face and the side surface of a circumferential groove formed in the pipe element during roll forming. The reduced contact area reduces frictional heating of the pipe and roller as well as the tendency of the roller to slip relative to the floor surface of the groove due to axial force engendered when an asymmetrical groove is formed.
US10189069B1	Portable tube bender A tube bender includes a bending tool and a bending base connected to the bending tool. The bending tool has an arched member. The bending base has a first plate, a second plate, a first block, and a second block. The first plate is separated from the second plate to form a bending space therebetween. The first and the second blocks are received in the bending space and pivoted on both the first plate and the second plate. A tube is adapted to be rested on the first and the second blocks while the arched member is able to be moved toward the tube to bend the tube. The first block and the second block are rotated automatically according to a curvature of the tube being bent.
US10189068B2	Bending press The invention relates to a bending press (1) for bending workpieces, comprising an upper tool (2) and a lower tool (3), a tool holder (4), in which the upper tool (2) is inserted, and a tool holder (5), in which the lower tool (3) is inserted, wherein the upper tool (2) and the lower tool (3) can be fixed in various positions within the respective tool holder (4, 5), a control device (13) for controlling the bending press (1), a sensor device (8), which is connected to the control device (13), and a stop (6) for positioning the workpiece within the bending press (1), wherein the stop (6) can be moved in relation to the tools (2, 3) by means of a drive (9) controlled by the control device (13). The sensor device (8) is designed to detect the position of the upper tool (2) and of the lower tool (3) within the bending press (1) without contact, and the control device (13) is designed to adapt the movement process by means of which the stop (6) is positioned in relation to the tools (2, 3), in dependence on the position of the upper tool (2) and of the lower tool (3) detected by means of the sensor device (8).
US10189065B2	Steel pipe, steel pipe structure, method of manufacturing steel pipe, and method of designing steel pipe In a steel pipe having a waveform shape formed on an outer diameter thereof by a pipe expansion process, a value a/w is 0.038% or less, where a and w denote an amplitude and a wavelength of the waveform shape, respectively. A method of manufacturing a steel pipe having a waveform shape formed on an outer diameter thereof by a pipe expansion process includes a step of forming the waveform shape such that a value a/w is 0.038% or less, where a and w denote an amplitude and a wavelength of the waveform shape, respectively.
US10189064B2	Control system and method for tapered structure construction A control system for forming a tapered structure includes a sensor providing feedback for a machine for forming a tapered structure including at least three rolls having at least one bend roll and at least two guide rolls. The guide rolls may include rollette banks having a plurality of rollettes. The machine may also include an adjustment mechanism to position at least one of the rolls, where a diameter of the tapered structure being formed is controlled by relative positions of the rolls. The machine may also include a joining element to join edges of a stock of material together as it is rolled through the rolls to form the tapered structure. The control system may also include a controller to receive feedback from the sensor and to send a control signal based on the feedback to the adjustment mechanism for positioning at least one of the rolls.
US10189060B2	Cable feeding device for drain cleaner A cable feeding device for a drain cleaner includes an upper body mounted on a support tube of the drain cleaner, a control subassembly, and a lower body. The upper body in which an upper feeding roller is held and the lower body in which two lower feeding rollers are held join each other, so that a cable inside a cable drum of the drain cleaner can extend through a region encircled with the upper and lower feeding rollers and can be resisted by the upper and lower feeding rollers for controllable forward or backward movements of the cable into a drain to be cleaned. The lower body has at least one separate mold-stripping hole for easy manufacturing of the upper and lower bodies in a plastic injection molding process. The upper and lower feeding rollers are not exposed to the outside for longer service life to hold the cable.
US10189056B1	Smart phone screen cleaning pad The planar cleaning pad for cleaning the screen of a smart phone or other similar electronic device includes a first surface, an opposed second surface and a periphery encircling the edges of the surfaces. The first surface is made from a microfiber fabric capable of cleaning the screen and the second surface includes a silicone capable of attaching to the back of the phone. The periphery of the pad has a thickness greater than the thickness of the remainder of the pad for ease in removing it from the back of the phone.
US10189054B2	Deviation handling apparatus and deviation handling method A deviation handling apparatus for a continuous production system of granulated products includes a storage section for temporarily storing the products, an inspection section for inspecting selected physical properties of the products, a moving route switching section for switching the moving route of the products according to the results of the inspection and a discharge path for discharging the products judged as not meeting the specifications. The storage section has two shutoff valves and a storage chamber formed therebetween. The switching section has a switching valve having a normal position and a deviation position for causing a conveyance route to communicate with the discharge path. The deviation handling apparatus closes the shutoff valves to store products in the storage chamber and inspect properties of the products. When off-specification products are detected, the switching valve is switched to the deviation position and the products are discharged.
US10189052B2	Methods of driving polarization inversion in ferroelectric materials and devices Methods and devices are described for driving ferroelectric perovskite oxide crystals to achieve polarization inversion with reduced coercivity. In some embodiments, the anisotropy in the potential energy surface of a ferroelectric material is employed to drive polarization inversion and switching with a reduced coercive field relative to uniaxial excitation. In some embodiments, polarization inversion with reduced coercivity is produced via the application of an electric field that exhibits a time-dependent orientation, in contrast with conventional uniaxial electrical excitation, thereby causing the central ion (and the crystal structure as a whole) to evolve along a lower-energy path, in which the central ion is driven such that it avoids the potential energy maximum. This may be achieved, for example, by applying at least two non-parallel time-dependent voltages (e.g. bias, potential) such that orientation of the electric field changes with time during the switching cycle.
US10189050B2	Electromechanical transducer and method of producing the same An electromechanical transducer includes a first electrode; a silicon oxide film disposed on the first electrode; and a vibration film including a silicon nitride film disposed on the silicon oxide film with a space therebetween and a second electrode disposed on the silicon nitride film so as to oppose the first electrode.
US10189046B2	Method and apparatus for prepping bores and curved inner surfaces with a rotating high-frequency forced pulsed waterjet A method of prepping a cylindrical inner surface of a bore using a high-frequency forced pulsed waterjet apparatus entails generating a pressurized waterjet using a high-pressure water pump, generating a high-frequency signal using a high-frequency signal generator, applying the high-frequency signal to a transducer having a microtip to cause the microtip to vibrate to thereby generate the high-frequency forced pulsed waterjet, and rotating the rotatable ultrasonic nozzle inside the bore to prep the inner cylindrical surface of the bore using the high-frequency forced pulsed waterjets exiting from the angled exit orifices of the rotatable ultrasonic nozzle.
US10189041B1	Apparatus and method for spraying color into cracks of a moving formed quartz slab to create veins in an engineered stone An apparatus including a device which moves a first portion of a soft, damp, and/or wet slab out of alignment with a majority of the slab and thus introduces a first crack in the slab; and a device for spraying a first colored material into the first crack of the slab. The device which moves the first portion of the slab out of alignment with the rest of the slab may include a first lift bar. The device for spraying the first colored material in the first crack of the slab may include a first spray bar having a plurality of nozzles fixed thereto, arranged in a substantially straight line. In at least one embodiment, the apparatus may also include a device which moves a second portion of the slab out of alignment with the majority of the slab and thereby introduces a second crack in the slab.
US10189038B2	Inductively heatable fluid reservoir for various fluid types In various embodiments, a fluid delivery pod includes a first surface, a second surface that opposes the first surface, a reservoir body, an outlet port, a heating structure, and a valve assembly. The reservoir body is between the first and the second surfaces. The reservoir body is configured to house a fluid. The outlet port is positioned on a surface of the pod. The surface is between the first and the second surfaces. The heating structure is thermally coupled to the fluid housed within the reservoir body. The heating structure wirelessly receives energy from an energy source that is external to the fluid delivery pod. The wirelessly received energy heats the fluid housed within the reservoir body. In response to an application of compression forces on the first and the second surfaces, the valve assembly dispenses the heated fluid through the outlet port and out of the fluid delivery pod.
US10189037B2	Easy-to-clean spray gun, accessories therefor, and mounting and dismounting methods A spray gun includes a one-piece main body, a trigger, a paint needle operating element coupled to the trigger, a paint needle coupled to the paint needle operating element, and an exchangeable spray agent guiding unit, the inlet region of which is or can be connected to a material supply device for the material to be sprayed, wherein the main body has at least one opening for receiving the exchangeable spray agent directing unit. Also disclosed is a material supply device, a cover, a method for mounting an exchangeable spray agent guiding unit in or on a spray gun having a one-piece main body, and a method for removing an exchangeable spray agent directing unit from or out of a one-piece spray gun.
US10189033B2	Deposition of coatings on substrates A process and apparatus are disclosed for the deposition of a layer of a first material onto a substrate of a second material. Powder particles of the first material are entrained into a carrier gas flow to form a powder beam directed to impinge on the substrate. This defines a powder beam footprint region at the substrate. The powder beam and the substrate are moved relative to each other to move the powder beam footprint relative to the substrate, thereby to deposit the layer of the first material. A laser is operated to cause direct, local heating of at least one of a forward substrate region and a powder beam footprint region. The laser beam direction is defined with reference to a plane coincident with or tangential to a surface of the substrate at the center of the laser beam footprint in terms of an elevation angle from the plane to the laser beam direction and in terms of an acute azimuthal angle from the movement direction to the laser beam direction. The elevation angle is 80° or less and the azimuthal angle is ±60° or less. In the apparatus, there are provided at least three laser sources arrayed around the powder beam footprint, the angular spacing between the laser sources being 120° or less.
US10189030B2	Shower head with a toroidal pulsator and a magnetic ring The invention relates to a shower arm with a torus regulator and a magnetic ring that is comprised of a body (1) with a body head (25), a bell (2), a cover (3), a torus (4), a mixing element (5), a ring (6), a pin (7) and a barrier (9) on the cover, a barrier (8) and a nozzle (10) on the bell, a cavity (11) for water inlet, an inlet (12) of water into the shower head (25), a space (13), a gap (14) on the mixing element, a chamber (15), gaskets (16) and (17), a thread (18), a space (19) for directed flow, pins (20) and a groove (21) on the ring, a groove (22) on the bell, a thread (23) for connecting a hose, a support surface (24), a magnetic ring (26) and an output spray (27) of water and air. When the water circulates within the space (19) underneath the torus (4), negative pressure—vacuum occurs from both the internal and the external sides of the torus cross-section that conditions suction of the air from the chamber (15) of the cone of the bell (2). This air is suctioned through the nozzle (10). In the space below the mixing element (5) the air and the water swirl which alternately enter into the air/water mixture and form a wide conical spray (27). The bell is provided with the groove (22), into which the ring (6) with pins (20) is tightly inserted. The pins are made from a soft material and serve for mechanical massage of the skin and the crown of the hair. On the other side in the ring there is the groove (21), into which the magnetic ring (26) is inserted. Its role is to normalize the water crystals and to arrange them into a natural shape. The nozzle (10) for spray outlet has an orifice large enough in order not to clog due to impurities in the water and limescale.
US10189029B2	Magnetic particle separator The magnetic particle separator uses an induced magnetic field to separate magnetic particles held in solution by magnetophoresis. The magnetic particles may be, for example, inherently paramagnetic or superparamagnetic, may be magnetically tagged or the like. First and second magnetic particles initially flow along a longitudinal direction. An external magnetic field along a lateral direction, orthogonal (or near orthogonal) to the longitudinal direction, is applied to an externally magnetizable wire, which extends along a transverse direction orthogonal to both the longitudinal and lateral directions. The external magnetic field generates an induced magnetic field in the externally magnetizable wire, and the induced magnetic field generates repulsive magnetic force on the first and second magnetic particles. Due to differing magnetic susceptibility, size and/or mass between the first and second magnetic particles, they are separated by following separate paths generated by the respective magnetic forces thereon.
US10189028B2	Method and apparatus for washing and grading aggregate An apparatus for washing and grading aggregate includes a chassis; a first grading screen mounted on the chassis for removing oversize material from a feed material; a first hydrocyclone mounted on the chassis receiving undersize material and water from the first grading screen; a second grading screen mounted on the chassis for producing at least one sand product, the second grading screen receiving an underflow from the first hydrocyclone; a second hydrocyclone mounted on the chassis receiving undersize material and water from the second grading screen; and an underflow from the second hydrocyclone being delivered onto the second grading screen.
US10189022B2	Microfluidic device A microfluidic device includes a substrate, first and second capillary inlets, a microfluidic channel unit, an outlet disposed downstream of the microfluidic channel unit, and a suction member disposed downstream of the outlet. A first liquid is drawn into a first sub-channel and a main channel of the microfluidic channel unit through the first capillary inlet. A second liquid is drawn into a second sub-channel of the microfluidic channel unit through the second capillary inlet. The suction member provides a predetermined suction force to permit the second liquid to penetrate into the first liquid and to break up into droplets in the first liquid, thereby generating monodisperse emulsions.
US10189018B2	Method and apparatus for dispensing precise aliquots of liquid A pipette controller for aspirating and dispensing multiple aliquots of a fluid from a reservoir of fluid. The pipette controller may include a pipette holder adapted to operatively connect a pipette to the pipette controller; a pressure tank pneumatically connected to the pipette holder; a pump pneumatically connected to the pressure tank and configured to inject air into the pressure tank to create positive air pressure inside the pressure tank; an aliquot valve controlling airflow between the pressure tank and the pipette holder; and an electronic control. The electronic control may open and close the aliquot valve.
US10189015B2	Hydroprocessing catalyst composition containing an acetoacetic acid compound, a method of making such a catalyst, and a process of using such catalyst A composition that comprises a support material having incorporated therein a metal component and impregnated with an additive compound that is an acetoacetic acid compound. The composition includes the support material that is impregnated with the additive compound and is useful in the hydroprocessing of hydrocarbon feedstocks, especially in the denitrogenation and desulfurization of distillate feedstocks to make ultra low sulfur diesel.
US10189014B2	Solid phosphoric acid catalysts The present disclosure relates to solid phosphoric acid (SPA) catalysts useful in the conversion of hydrocarbons, such as the oligomerization of olefins, to methods for making such SPA catalysts, and to methods for converting hydrocarbons by contacting hydrocarbons with such catalyst. For example, in certain embodiments, the disclosure provides a calcined solid phosphoric acid catalyst composition that includes phosphoric acid and silicon phosphates, and in which (i) one or more promoters each selected from the group consisting of boron, bismuth, tungsten, silver and lanthanum is present; (ii) the composition is a calcined product of a formable mixture including silica-alumina clay, silica fiber and/or silica alumina fiber; or (iii) the composition is a calcined product of a formable mixture including fumed silica.
US10189012B2	Preparation of catalyst A process for preparing a hydrocarbon conversion catalyst that comprises a specially made silica-alumina composition and a metal or metal compound selected from Group VIB and Group VIII metals. The silica-alumina composition is made by preparing an aqueous mixture containing aluminum sulfate followed by adding alkali metal aluminate to the mixture to enhance the pH to within specified range and then adding aluminum sulfate to the mixture to lower the pH. Then alkali metal silicate is added followed by several other pH swings to provide a mixture containing silica-alumina. The resulting mixture is treated with an alkaline solution to provide a precipitate solid that is recovered to obtain a silica-alumina composition containing of from 30 to 70% wt silica and of from 70 to 30% wt of alumina.
US10189009B2	Particulate water absorbing agent and method for manufacturing same A water absorbent resin (water absorbing agent) and method for producing it are provided which improve, in a water absorbent article (in particular, a diaper) including a water absorbent resin as a water absorbing agent, the absolute absorption amount (g), liquid absorbing times (in particular, liquid absorbing times at the second instance and later), re-wet (g), and diffusion distance (%) of the water absorbent article.A particulate water absorbing agent of the present invention has a CRC, a proportion of particles with sizes of 600 μm to 150 μm as defined through a standard-sieve classification, an SST, and the value of the difference between an FST and the SST each within a predetermined range.
US10189007B2	Method for producing porous cellulose beads and adsorbent employing same The objective of the present invention is to provide a method for easily and efficiently producing cellulose beads which have pore shape suitable for an adsorbent and of which adsorption performance is excellent without using highly toxic and highly corrosive auxiliary raw material and without industrially disadvantageous cumbersome step. The method for producing porous cellulose beads according to the present invention is characterized in comprising (a) the step of preparing a fine cellulose dispersion by mixing a low temperature alkaline aqueous solution and cellulose, (b) the step of preparing a mixed liquid by adding a crosslinking agent to the fine cellulose dispersion, (c) the step of preparing an emulsion by dispersing the mixed liquid in a dispersion medium, (d) the step of contacting the emulsion with a coagulating solvent.
US10189006B2	Integral 3D graphene-carbon hybrid foam Provided is an integral 3D graphene-carbon hybrid foam composed of multiple pores and pore walls, wherein the pore walls contain single-layer or few-layer graphene sheets chemically bonded by a carbon material having a carbon material-to-graphene weight ratio from 1/100 to 1/2, wherein the few-layer graphene sheets have 2-10 layers of stacked graphene planes having an inter-plane spacing d002 from 0.3354 nm to 0.40 nm and the graphene sheets contain a pristine graphene material having essentially zero % of non-carbon elements, or a non-pristine graphene material having 0.01% to 25% by weight of non-carbon elements wherein said non-pristine graphene is selected from graphene oxide, reduced graphene oxide, graphene fluoride, graphene chloride, graphene bromide, graphene iodide, hydrogenated graphene, nitrogenated graphene, doped graphene, chemically functionalized graphene, or a combination thereof. Also provided are a process for producing the hybrid form, products containing the hybrid foam, and its applications.
US10188997B2	Scallop support distributor for radial flow reactor The invention provides a support distributor for a scallop for use in a radial flow reactor. The support distributor includes an elongated sheet having a plurality of perforations extending through a thickness thereof, and at least three edges along a length thereof so as to form a member having at least three support points which engage an inner surface of the scallop.
US10188992B2	Polybenzimidazoles and methods of making and using thereof Disclosed are polybenzimidazoles containing sulfonyl groups. The polymers can be synthesized in Eaton's reagent from 3,3′,4,4′-tetraaminodiphenylsulfone, which itself can be synthesized from 4,4′-dichlorodiphenylsulfone. Methods of synthesizing the polymers are disclosed. The disclosed polymers can be used for high temperature H2/CO2 separation membranes and other uses.
US10188986B2	Electrochemical reductant generation while dosing DEF A diesel exhaust fluid (DEF) doser includes a DEF inlet configured to receive DEF, a DEF outlet configured to spray DEF out of the DEF doser, and an electrochemical cell. The electrochemical cell is located between the DEF inlet and the DEF outlet and couplable to a power source. The electrochemical cell is configured such that, when DEF is flowing from the DEF inlet to the DEF outlet and when the electrochemical cell is coupled to the power source, the electrochemical cell causes an electrolytic reaction in the DEF flowing from the DEF inlet to the DEF outlet to produce gaseous products in the DEF flowing from the DEF inlet to the DEF outlet, and wherein the gaseous products comprise one or more of H2 or NH3.
US10188981B2	Mixed matrix membrane, a method of making thereof, and a method for gas separation A mixed matrix membrane which is porous and has a cross section resembling a sponge. The membrane includes nanoparticle fillers which are also porous. The membrane may be freestanding or supported on a substrate. Methods of making the membrane by spin casting or solvent casting are described. Methods of separating a gas/organic vapor using the membrane are described.
US10188980B2	Coal upgrade plant and method for manufacturing upgraded coal A coal upgrade plant includes: a dryer 1 that heats and dries coal before pyrolyzing the coal; a scrubber 32 that treats a carrier gas discharged from the dryer 1 while catching a desorbed component desorbed from the coal when the coal is dried by the dryer 1; a waste water treatment equipment 40 that treats waste water collected from the scrubber 32; and the scrubber 32 that uses recycled water treated in the waste water treatment equipment 40. Thus, water supplied to the coal upgrade plant from outside can be reduced as much as possible.
US10188977B2	Polymeric netting of ribbons and strands and methods of making the same A polymeric netting including polymeric ribbons and polymeric strands. Each of the polymeric ribbons and strands has a length and width, with the length being the longest dimension and the width being the shortest dimension. The polymeric ribbons have a height-to-width aspect ratio of at least five to one, a major surface that is intermittently bonded to only one polymeric strand, and a height greater than the height of the one polymeric strand. An extrusion die and method useful for making the polymeric netting are also disclosed.
US10188975B2	Honeycomb air filter and methods thereof An air filter, including: at least one wall-flow honeycomb particulate filter having at least one coat on at least a portion of the interior surface of the filter, wherein the at least one coat comprises at least one of: a sorbent; a catalyst; or a combination thereof, and the air filter, in-use, retains from filtered air at least one of: a particulate, a volatile organic compound, or a combination thereof. Also disclosed is an interior air purification system including the air filter, and methods of making and using the air filter.
US10188972B2	Water purifying apparatus and filter structure A water purifying apparatus including a head having a water inlet portion and a water outlet portion; a shaft provided in the head and rotatably mounted between the water inlet portion and the water outlet portion; a bypass flow path passing through a circumference of the shaft, and communicating the water inlet portion with the water outlet portion according to rotation of the shaft; a filter detachably mounted to the head, and having a filter inserting portion in which the shaft is inserted when being mounted on the head; and a filtering flow path in which an inlet port and an outlet port are formed on the circumference of the shaft in a direction intersecting the bypass flow path, and communicated between the filter, the water inlet portion and the water outlet portion with each other according to the rotation of the shaft.
US10188968B2	Candle filter support and plate assembly for polymer melts A polymer melt candle filter having a support which comprises a hollow cylindrical body defined by a first end, a second end, and a cylinder wall having a first end portion and a second end portion. The first end portion includes a screw thread on its outside surface and optionally a hex fitting on its inside surface for receiving a hex wrench. The second end portion includes a plurality of holes in the cylinder wall. The area of the openings of the holes on the outside surface of the cylinder wall may be larger than the area of the openings of the corresponding holes on the inside surface of the cylinder wall. The shape of the openings of the holes on the outside surface may be non-circular. A polymer melt filter plate assembly which comprises (a) a support plate comprising a plurality of threaded holes; (b) at least one filter which is screwed into at least one of the threaded holes via the screw thread on the outside surface of the first end portion of the filter support; (c) a tie rod with (i) a first end extending through a hole in a cone insert and a cap located at the second end of the filter support, and (ii) a second end extending through a threaded hole in the support plate; and (d) a cross bar which is attached to the second end of the tie rod for holding the support plate inside a shaft of an apparatus for filtering a polymer melt.
US10188966B2	Impurities or materials trapping apparatus The present invention comprises an impurities or materials trapping apparatus for separating or trapping a selected or unwanted materials such as sediment in a pourable material having sediment therein. The apparatus comprises a body having side walls between a first end and second end defining at least a recessed inner space 42, 104, 204, 286 there between for a pourable material. The apparatus includes at least one raised portion 50, 51, 55, 56, 206, 208 having a highest point, angled walls 26 connected to the side walls 7, 40 202, 220, 282 and at least one drainage aperture 16, 110, 210 located within the side walls 7, 40, 202, 220 282 or angled walls 26, 103, 203, 284. The raised portion is located at one end of the inner space and the angled walls 26 are located at a spaced distance from the raised portion. In one orientation of the apparatus, the side walls or angled walls drain at least a portion of the pourable material towards and though the drainage aperture and down to the raised portion and in another orientation of the apparatus, the drainage aperture is blocked thereby retaining any sediment. The apparatus of the present invention can be formed as part of a container or bottle and/or be part of a cap assembly. Methods of operation are also included.
US10188965B2	Hydrophobic charge induction chromatographic depletion of a protein from a solution The present invention relates generally to a method of reducing the level of at least one protein selected from the group consisting of plasminogen, tissue plasminogen activator and other protease(s) in a solution comprising at least one protein selected from the group consisting of fibrinogen, Factor VIII and von Willebrand factor (VWF), the method comprising: (i) passing a feedstock comprising at least one protein selected from the group consisting of fibrinogen, Factor VIII and VWF through a hydrophobic charge-induction chromatographic resin under conditions selected such that at least one protein selected from the group consisting of plasminogen, tissue plasminogen activator and other protease(s) present in the feedstock is bound to the resin; and (ii) recovering a solution comprising the at least one protein selected from the group consisting of fibrinogen, Factor VIII and VWF which passes through the resin, wherein the concentration of the at least one protein selected from the group consisting of plasminogen, tissue plasminogen activator and other protease(s) in the solution is reduced by at least 50% compared to the feedstock. Also provided are solutions and pharmaceutical formulations comprising the fibrinogen and/or Factor VIII and/or VWF recovered by such methods, and uses thereof.
US10188964B2	Chromatography columns A method of making and loading a chromatography column includes selecting a column tube having an appropriate elasticity, and inner diameter and length, selecting appropriately sized flow distributors, a second flow distributor having a diameter that is larger than the inner diameter of the tube, permanently securing a first flow distributor to a first end of the tube, loading packing medium into the tube, inserting the second flow distributor into a second end of the tube to drive the second flow distributor into the tube to form a sealed chamber within the tube, adjusting the longitudinal position of the second flow distributor within the tube by applying a force to the second flow distributor until it reaches a desired location within the tube, and/or forcing liquid into the chamber to move the second flow distributor and permanently securing the properly positioned second flow distributor within the tube.
US10188963B2	Reactor for biological or chemical transformation The present invention relates to a new reactor for performing, by means of at least one solid reaction member, biological or chemical transformation, or physical or chemical trapping from, or release of agents to, a fluidic medium, which reactor is comprised of a reactor vessel comprising means for enhancing fluidic shear stress, and a transformation device operatively mounted in said reactor vessel. The invention also provides a kit of parts comprising a reactor vessel comprising means for enhancing fluidic shear stress and a transformation device. Finally, the invention provides a method of using said reactor and/or said kit of parts for biological or chemical transformation or physical or chemical trapping from, or release of agents to, a fluidic medium, by means of at least one solid reaction member.
US10188960B2	Interlocking building block An apparatus, system, and method are disclosed for building a structure that includes a substantially triangular cross-sectional shape having an outside face opposing an inside face. The outside face is connected to the inside face by a first wall, a second wall, and a third wall. Each wall includes a first projection has an outer surface that is continuous with the outside face, a first recess that is positioned opposite and extends away from the first projection, a second projection that has an inner surface that is continuous with the inside face, a second recess that is positioned opposite and extends away from the second projection, and a coupling projection. The coupling projection is positioned opposite at least one of the first recess and the second recess.
US10188957B2	Toy with proximity-based interactive features Presented herein are techniques in which the proximity of an object to a toy is determined using a photosensor (photo sensor) circuit. The proximity is classified/categorized as falling into one of a plurality of different proximity ranges. The proximity range in which the object is located is mapped to one or more audible or visual outputs, where the audible or visual outputs are adjusted/varied as the relative proximity of the object to the toy changes.
US10188954B1	Arcade game with integrated beverage sensor An arcade game includes a beverage receptacle to hold a beverage container in an upright orientation and a beverage sensor to distinguish one or more beverage states and to communicate the distinguished one or more beverage states to the arcade game as gameplay activation inputs to the arcade game. The arcade game can also include features to proof the game against spillage of beverages onto and into the game cabinet, including gutters and a reservoir housing antimicrobial sponges. The system can compile usage data and deliver it to a business proprietor to provide customer consumption information.
US10188953B2	Dual-range wireless interactive entertainment device A method of interactive game play is provided wherein a seemingly magical wand toy is provided for enabling a trained user to electronically send and receive information to and from other wand toys, a master system and/or to actuate various play effects within a play environment. The toy wand or other seemingly magical object is configured to use a send/received radio frequency communications protocol which provides a basic foundation for a complex, interactive entertainment system to create a seemingly magical interactive play experience.
US10188952B1	Method for dynamically mapping servers A method for variable sized summarization of n-dimensional integral coordinate systems. A three or other dimensional area is defined with an integral coordinate system. Blocks are defined within the three or other dimensional area with coordinate summary addresses. The coordinate addresses are mapped to server coordinates so that each block can be independently stored on one or more servers.
US10188945B2	Generation of gameplay video based on social network sharing A method, including: executing, by a cloud gaming system, a session of a video game; recording the user's gameplay of the video game; analyzing the user's recorded gameplay to determine a region of interest, the region of interest being a region of the video game having social network sharing levels that exceed a predefined threshold; during the session of the video game, receiving a request from the client device, the request being initiated from a button of a controller device interfaced to the client device; responsive to the request, presenting, through the client device, the region of interest; generating, by the cloud gaming system, a gameplay video of the video game based on the region of interest; sharing the gameplay video of the video game over the social network to one or more additional client devices for viewing by one or more additional users.
US10188944B2	Facilitating users to complete active game actions A system and method for providing offers to facilitate users to complete active game actions in a game space are disclosed. Offers to forego a group of pending wait periods of active game actions may be generated and presented to the users at the same time or near the same time along with offers to forego these pending wait periods individually and separately. In some examples, for incentivizing the users to accept the offer to forego the group of pending wait periods, a discount may be determined for these offers with respect to the offers to forego the group of pending wait periods individually and separately. In some examples, selection of the group of pending wait periods may be made based on likelihoods as to whether the users will spend stored consideration to forego the group of pending wait periods individually and separately.
US10188938B1	Action or position triggers in a game play mode A method, apparatus and non-transitory computer readable medium that, in one embodiment, interprets a user motion sequence comprises beginning a session, capturing the user motion sequence via a motion capturing device during the session, processing, via a processor, the user motion sequence into a predetermined data format, comparing the processed user motion sequence to at least one predetermined motion sequence stored in a database and determining whether to perform at least one of interpreting the user motion sequence as a universal command and registering the user motion sequence as a new command.
US10188931B2	Smart baseball first base or home plate Briefly, in accordance with one or more embodiments, a smart base for a baseball system or a softball system comprises a sensor to detect a first time at which a runner has touched the smart base, a radio-frequency (RF) receiver to receive a signal from a smart baseball that indicates a second time at which the smart baseball was caught, timing circuitry to detect if the second time occurs before or after the first time; and indicator circuitry to indicate a force out if the second time occurs before the first time.
US10188929B2	Adapted fitness equipment An exercise apparatus includes an adjustable frame being attachable to an assistive ambulation device. The adjustable frame includes removable handles, fitting arms located on a lower portion of the adjustable frame to receive a fitness attachment, and attachment points on located on the lower portion of the adjustable frame to couple a resistance device. A jump rope trainer includes a handle; flexible tubing including a handle fastener to connect the handle to the flexible tubing; and a soft sphere shaped object. The flexible tubing includes a soft sphere shaped object fastener to connect the soft sphere shaped object to the flexible tubing.
US10188928B1	Convertible golf alignment and measurement device A golf device including a first elongated portion. The golf device may include a second elongated portion. The golf device may include an arch portion slideably engageable inside the first elongated portion and the second elongated portion.
US10188925B2	Ball rebounding system A ball rebounder has inelastic netting that is pulled taught and held in place within a frame using tension rods, inelastic fasteners, and a tensioning mechanism between the frame and the tension rods. The tension rods are connected to the cells of the netting and positioned in the interior space. The tensioning mechanism pulls the tension rods toward the corresponding sides of the frame, drawing the net taught within the frame. With the netting pulled taught, the fasteners hold the tension rods in place next to the sides of the frame. The frame can be rigid or may have flexibility and act like a spring, but there are no intermediate springs between the tension rods and the frame or between the tension rod and the netting. The invention can be used in producing new rebounders and in retrofitting existing rebounder frames.
US10188922B1	Putting skill game The putting game device provides a rigid putting surface with an attached green that leads to a ramp. The ramp and putting surface store within a housing to create a mobile game that is easily stored and transported. The housing includes a support to angle the housing and the game board for play. Each game board provides at least one cup, preferably multiple cups, for the user to putt the ball into. The targets may be simple holes in the game board or the targets may be a raised target that extends vertically above the game board. The game device also enables the installation of different game boards for different target arrangements.
US10188917B2	Weighted iron set The present invention is direct to a set of golf clubs comprising long irons, mid-irons and short irons. The invention contemplates the use of titanium or steel for the main body portion and significant tungsten weight members coupled to at least the toe via a mechanical fastener inserted through the face.
US10188914B2	Golf club head A golf club head includes a crown portion and a face portion. The crown portion includes a first protruding portion arranged on the side of the face portion, and a second protruding portion arranged on the back side to be adjacent to the first protruding portion. The width of the first protruding portion in the face-back direction on a plane passing through the face center of the face portion and extending in the vertical direction is smaller than the width of the second protruding portion in the face-back direction. The protruding height of the second protruding portion is larger than the protruding height of the first protruding portion.
US10188913B2	Interchangeable shaft system A golf club incorporating an interchangeable shaft system includes a shaft, a shaft sleeve, a club head. The shaft sleeve is coupled to an end of the shaft and is received in a hosel included in the club head. The shaft sleeve is removably coupled to the club head. Alignment features on the components provide discrete orientations between the shaft and club head. The shaft sleeve may be constructed from non-metallic material.
US10188911B2	Golf ball A golf ball 2 includes a core 4, a mid layer 6, and a cover 8. A hardness H75 at a point to which a distance from a central point of the core 4 is 75% of a radius of the core 4 is greater than a hardness H0 at the central point of the core 4. A difference D1=(H75−H0) is not less than 10.0 and not greater than 27.0 in Shore C hardness. A hardness Hs at a surface of the core 4 is greater than the hardness H75. A difference D2=(Hs−H75) is not less than 0 and not greater than 6.5 in Shore C hardness. The hardness H75 is less than a Shore C hardness HmC of the mid layer 6. A Shore D hardness HmD of the mid layer 6 is greater than a Shore D hardness Hc of the cover 8.
US10188902B2	Signal analysis and recharging system A measurement device may include one or more piezoelectric elements that output power signals. The device may split each power signal, analyzing a first portion of the signal while supplying a second portion to an energy storage assembly. A processor may dynamically adjust the first and second portions of each power signal to change how much of each power signal is used for signal processing versus energy storage, and may make the adjustments based on detected activities and/or pre-programmed timelines. The device may be used in or on sports equipment, such as a golf club.
US10188900B2	Extension base for exercise apparatus An extension base for an exercise apparatus includes a stationary seat that is attached to a bottom of a frame of the exercise apparatus and defines therein a channel; and two extension legs that are inserted into the channel of the stationary seat from two openings at two ends of the stationary seat, so that the extension legs can be extended or retracted with respect to the stationary seat. When the extension legs are fully retracted into the stationary seat, a distance between the outer ends of the two extension legs farthest away from each other is still long enough to support the elliptical exerciser and prevent it from falling. The extension base solves the problem that the conventional exercise apparatus tends to rollover when its base is removed.
US10188894B2	Barbell A barbell includes a grip unit, a support unit and a carrier unit. The grip unit includes two frames spaced apart from each other along a first direction, and a grip rod connected between the frames and configured to be gripped by a user's hand. The support unit includes at least one support member that is connected between the frames, that is spaced apart from the grip rod along a second direction transverse to the first direction, and that is configured to abut against a user's forearm. The carrier unit includes two hanging rods extending outwardly and respectively from the frames and located between the grip rod and the at least one support member.
US10188891B2	Stepper machine with elastic resistance generating component Embodiments of an exercise machine are disclosed. In one embodiment, an exercise machine includes a base frame, a pair of left and right pedal assemblies, and a pedal supporting assembly. The base frame is adapted to be positioned on a support surface. The left and right pedal assemblies have a pair of left and right pedals, and each is positioned over and rotatably supported by the base frame. The pedal supporting assembly is attached to the base frame and configured to pivot around an axis. The pedal supporting assembly also supports the left and right pedal assemblies. The pedal supporting assembly is operable to generate resistance in response to movement of the left and right pedals and the pedal supporting assembly pivoting around the axis.
US10188890B2	Magnetic resistance mechanism in a cable machine A cable exercise machine includes a first pull cable and a second pull cable incorporated into a frame. Each of the first pull cable and the second pull cable are linked to at least one resistance mechanism. The at least one resistance mechanism includes a flywheel and a magnetic unit arranged to resist movement of the flywheel.
US10188885B2	High nitrogen and other inert gas anti-corrosion protection in wet pipe fire protection system A wet pipe fire protection sprinkler system and method of operating a wet pipe fire sprinkler system includes providing a sprinkler system having a pipe network, a source of water for the pipe network, at least one sprinkler head connected with the pipe network and a drain valve for draining the pipe network. An inert gas source, such as a nitrogen gas source, is connected with the pipe network. Inert gas is supplied from the inert gas source to the pipe network. Water is supplied to the pipe network thereby substantially filling the pipe network with water and compressing the inert gas in the pipe network.
US10188884B2	Structurally-installed access device for accepting connection by a fire hose nozzle to introduce firefighting fluid into an enclosed space of a structure A nozzle access device is configured to be installed in a structural element and to accept connection by a fire hose nozzle to introduce firefighting fluid into an enclosed space. The device has a housing configured to be inserted in a hole formed in the structural element. The housing has a cylindrical body and a first face with an opening surrounded by an inwardly extending cylindrical socket. The housing has a second face, with an opening, which is attached to the cylindrical body. A movable nozzle connector in the housing has a connection portion configured to receive an inserted fire hose nozzle in a locking connection and a cylindrical nozzle stop portion extending from the connection portion. The nozzle stop portion is movably coupled within an interior of the socket of the first face.
US10188883B2	Process to stop and/or prevent the spreading of peat fires Process to stop and/or prevent the spreading of peat fires consisting of: digging a trench in the periphery of the area of outbreak of fire or potential fire, filling the trench at least partially with a superabsorbent (co)polymer (SAP).
US10188882B2	Component for fitting to a safety harness A component for fitting to a safety harness for a human user, for at least partially preventing obstruction of the femoral vein of the user. The component includes a support structure; two leg harness pads fitted to the support structure at such a distance from one another that, when the component is fitted to the safety harness, a section of the support structure arranged between the two leg harness pads, in particular a section without a leg harness pad, at least partially prevents obstruction of the femoral vein of the user, if the user has put on the safety harness; and a detachable fastening mechanism, that is fitted or can be fitted to the support structure, for detachably fastening the component to the safety harness.
US10188880B2	Filter assembly for a breathing apparatus A filter assembly for a breathing apparatus, such as a powered air purifying respirator. The filter assembly includes a frame for receiving and retaining a filter element, a cover connected to the frame and dimensioned to cover the aperture, a filter element, and an indicator for indicating when the filter element is retained in the filter frame and the cover is arranged across the aperture. A powered breathing apparatus including the filter assembly is also disclosed.
US10188879B2	Breathing circuit device The invention relates to a respiratory circuit appliance with a respiratory line, a CO2 absorber (6) in the respiratory line, and a cooling device for cooling the respiratory gas after it exits the CO2 absorber. Provision is made that the cooling device cools a heating pump with a compressor (33) for compressing/condensing a cooling medium, a condenser (30), which receives the condensed cooling medium, and in so doing releases heat to the surroundings, and with a heat exchanger body (8) which receives the cooled cooling medium and is in heat-conducting contact with a section of the respiratory line.
US10188876B2	Locally injectable dosimetric organ spacer The present invention relates to a system, a method and a filler for measuring a dose of ionizing radiation received by a pre-determined part of the body during radiotherapy while creating a space between the organ to be irradiated and organs to be protected. The invention also relates to uses of such filler. The system comprises an injectable dosimetric filler, which under the influence of ionizing irradiation undergoes measurable physical and/or chemical changes, while preserving its spatial integrity; a detector system for measuring the physical and/or chemical changes within the radiation sensitive filler by sending an energy wave to the radiation sensitive filler and capturing the signal emitted therefrom; and a control unit for processing the signal captured by the detector system and calculating a dose of ionizing radiation previously or simultaneously received by each part of the volume of the radiation sensitive filler on the basis of said signal.
US10188871B2	Flat optogenetic cuff interface (FOCI) for a single nerve fascicle of the peripheral nervous system A flat optogenetic cuff interface (FOCI) is configured for functional optical stimulation of axons in a single fascicle of a peripheral nerve bundle in which the axons have been genetically modified to express light sensitive proteins for excitation or inhibition of the nerves. The FOCI is configured to gradually reshape the single fascicle to a final height between 0.2 mm and 0.5 mm by reorganizing the individual axons within the fascicle without reshaping (and damaging) the individual axons. The FOCI facilitates stimulation of axons over the entire cross-section of the reshaped fascicle within the power limitations for pulsed laser energy. An electrical interface may be included to sense nerve activity of either the stimulated axons to provide closed-loop feedback to control the optical sources or stimulated axons of a different modality to record the response. The FOCI may be used as an interface for prosthetic devices to restore lost sensory or motor function, to augment human sensor or motor performance or to modulate autonomic functions.
US10188869B2	Hardware/software integrated design for a 3D tremor detector using TMS in Parkinson's disease and related disorders Systems that integrate Transcranial Stimulation Biofeedback (TSB) Detector functions and Transcranial Magnetic Stimulation (TMS) functions, as well as methods of manufacturing such systems and methods of performing TSB detection and TMS using such systems, are provided. A system can include a hardware component and a software component in operable communication with the hardware component. The hardware component can include or be in operable communication with a TMS machine, and the software component can be configured to receive waveforms from the TSB Detector hardware.
US10188868B2	Device support apparatus According to an example embodiment of the present invention, there is provided an apparatus, comprising a first arm configured to accept a device, the first arm comprising a first counterweight arrangement, a second arm supporting the first arm by a coupling, and a base defining a curve and having the second arm mounted thereon, wherein the second arm is movable along the curve, the base configured to be mounted on a chair. The second arm may be furnished with a second counterweight arrangement.
US10188865B2	Systems and methods of combined tonic DBS and random DBS The present disclosure provides systems and methods for combining tonic deep brain stimulation (DBS) and random DBS. A system includes a stimulation lead including a plurality of contacts, and an implantable pulse generator (IPG) communicatively coupled to the stimulation lead and configured to cause tonic stimulation to be delivered using one contact of the plurality of contacts, and cause random stimulation to be delivered using a subset of the remaining contacts of the plurality of contacts.
US10188864B2	Systems and methods for tissue stimulation in medical treatment Stimulation treatments for various medical disorders, such as neurological disorders, comprise novel systems, strategies, and methods for providing TMS, electrical, magnetic, optical and other stimulation. Some stimulation methods comprise varying the stimulation parameters to improve the therapeutic efficacy of stimulation, and decrease risk of habituation and side-effects such as interference with normal brain, sensory, motor, and cognitive processes. The creation, and subsequent variation, of stimulation parameters can use sensed data in order to match, adjust, or avoid matching characteristics of the stimulation therapy relative to certain endogenous brain activities. Novel methods are described for choosing, creating and subsequently stimulating with partial signals which summate to produce therapeutic vector fields having unique temporal patterns and low- or high-frequency spectral content.
US10188863B2	Therapy program selection for electrical stimulation therapy based on a volume of tissue activation In some examples, a processor of a system evaluates a therapy program based on a score determined based on a volume of tissue expected to be activated (“VTA”) by therapy delivery according to the therapy program. The score may be determined using a three-dimensional (3D) grid comprising a plurality of voxels that are each assigned a value. The processor may register the VTA with the 3D grid and determine the score for the therapy program based on the values assigned to voxels with which the VTA overlaps. One or more therapy programs for electrical stimulation therapy (e.g., deep brain stimulation) may be selected based on the scores determined based on the 3D grid.
US10188861B2	Bioabsorbable or partially-bioabsorbable bone growth stimulator system and method for manufacturing a bioabsorbable or partially-bioabsorbable bone-regeneration stimulator system A bone growth simulator system. A bioabsorbable electric circuit is encapsulated in a modified alginate known-time dissolving capsule having a rate of dissolving proportional to the thickness of the capsule. The electronic circuit is powered by a power source. The power source can be inside the capsule or outside the capsule, and can be bioabsorbable or at least biocompatible. An operational amplifier maintains constant current through the circuit. The current stimulates bone growth in bones adjacent to the circuit. The capsule and electric circuit dissolve after completion of the therapy.
US10188858B2	Method and device for treating a tissue with a high frequency electromagnetic field Methods and systems for treating a tissue with a high frequency electric field to activate MAPK/ERK pathways, induce angiogenesis, induce angionenic factos such as NO and VEGF, or promote wound healing. Aspects of the invention are directed to methods of treating chronic wounds such as diabetic ulcers and hypoxia induced wounds. Aspects utilize high frequency electric field having a frequency in the GHz range, and preferably between about 1 GHz and about 10 GHz.
US10188857B2	Lead identification system In some examples, a lead identification system includes a first set of first lead indicators and a second set of second lead indicators. Each of the first lead indicators is configured to removably attach to at least one of a first therapy delivery element, a first epidural needle, or a first connector to uniquely identify at least one of the first therapy delivery element, the first epidural needle, or the first connector during implantation of the first therapy delivery element in the patient. Each of the second lead indicators is configured to removably attach to at least one of a second therapy delivery element, a second epidural needle, or a second connector to uniquely identify at least one of the second therapy delivery element, the second epidural needle, or the second connector during implantation of the second therapy delivery element in the patient.
US10188856B1	Implantable device for providing electrical stimulation of cervical vagus nerves for treatment of chronic cardiac dysfunction An implantable device for providing electrical stimulation of cervical vagus nerves for treatment of chronic cardiac dysfunction is provided. A stimulation therapy lead includes helical electrodes configured to conform to an outer diameter of a cervical vagus nerve sheath, and a set of connector pins electrically connected to the helical electrodes. A neurostimulator includes an electrical receptacle into which the connector pins are securely and electrically coupled. The neurostimulator also includes a pulse generator configured to therapeutically stimulate the vagus nerve through the helical electrodes in alternating cycles of stimuli application and stimuli inhibition that are tuned to both efferently activate the heart's intrinsic nervous system and afferently activate the patient's central reflexes by triggering bi-directional action potentials.
US10188853B2	Flexible circuit electrode array with a drum stress relief The present invention is a flexible circuit electrode array with a polymer base layer, metal traces deposited on the polymer base layer, including electrodes suitable to stimulate neural tissue, a polymer top layer deposited on the polymer base layer and the metal traces, and a soft polymer filling a void through both the polymer base layer and polymer top layer, the soft polymer forming drum stress relief around an attachment point.
US10188849B2	Systems, methods, and components for transferring medical fluids An example of a method of enabling medical fluid transfer between a source container and a destination container can comprise the steps of providing a closed-system fluid transfer module comprising a first closeable, resealable medical connector and a second closeable, resealable medical connector, a multidirectional fluid control valve with a driving interface configured to interface with an electromechanical driver of an electronic medical fluid transfer device, and an intermediate container or an intermediate pumping region; and instructing a user to couple the closed-system fluid transfer module to the electronic medical fluid transfer device.
US10188827B2	Distal closing catheters and methods for same A catheter for insertion into a body cavity of a subject (such as the urinary bladder), and having a drainage tube extending from a drainage opening adjacent a distal end of the catheter to a drainage outlet adjacent a proximal end of the catheter; a closure member mountable for sliding movement within the drainage tube between a first position such that said drainage opening is in fluid communication with the drainage outlet and a second position wherein the closure member blocks fluid communication between the drainage opening and the outlet port; and an actuator, operable from the proximal end of the catheter, to move the closure member between the first and second positions. The closure member can include a second tube, sliding within the drainage tube, or a slideable plug.
US10188825B2	Humidifier for a respiratory assistance device, a respiratory assistance device and related methods and apparatus A humidifier for a respiratory assistance device, is provided wherein at least a portion of an inside of a chamber is exposed to light such that light impinges on a metallic or carbon-based material to generate localized heating of liquid molecules around the metallic or carbon-based material and generate vapour for use by the respiratory assistance device. A respiratory assistance device comprising a humidifier and related methods and apparatus are also provided. Arrangements are provided for generating vapour by impinging light on metallic and/or carbon based material, particularly in the form of nanoparticles.
US10188824B2	Aerostasis in pulmonary surgery A device for use in pulmonary surgery is presented. The device includes a dispensing apparatus 300, 400, 900, a delivery apparatus 100, 1000, 1100, in fluid communication with said dispensing apparatus, and a pressurized gas input 338. The dispensing apparatus is configured to provide a pressurized gas, a fibrinogen stream, and a thrombin stream to the delivery apparatus. The delivery apparatus is configured to mix the fibrogen stream and the thrombin stream in the pressurized gas stream to form a fibrin reaction mixture comprising a cellular foam 700.
US10188823B2	Continuous high pressure delivery system A drug delivery system, which includes an aerosol generator unit, a pumping unit, a flow tube, at least one condensate collector and an aerosol transition adapter. The aerosol generator forms an aerosol from a liquid formulation, which is partially volatilized. The pumping unit supplies the liquid formulation to the aerosol generator unit and a flow tube having an inlet end in fluid communication with an outlet of the aerosol generator unit and an outlet adapted for connection to a patient interface, which supplies ventilation gas to a patient's lungs. The system also includes at least one condensate collector adapted to collect condensed liquid or liquid produced by the aerosol generator unit, and a transition adapter arranged to mix aerosol produced by the aerosol generator unit with heated air or ventilation gas and direct the mixed aerosol into the inlet end of the flow passage.
US10188817B2	Speaking valve The invention relates to a speaking valve for laryngectomized and tracheotomized persons that is easy and economical to produce. According to the invention, the speaking valve comprises a proximal first opening and a distal second opening, a filter, which is at least partially surrounded by the housing, which filter is made of an elastic material, and has a proximal first end and a distal second end, wherein the filter partially protrudes beyond an end face of the housing at the distal second opening, and wherein a cover is connected by means of at least one partial region of the bottom surface thereof to a top side of the filter at the distal second end of the filter. A diameter d1 of the cover is greater than a diameter d2 of the filter, such that an edge projecting beyond a lateral filter wall of the filter is formed, wherein by application of pressure to the cover from an initial position, a bottom surface of the edge at least partially interacts with the end face of the housing in order to produce a closed position of the speaking valve, and wherein the cover together with the filter returns to the initial position when unloaded.
US10188816B2	System for removing infectious secretions A tracheal/endotracheal device that has an integrated system for removing mucins and similar infectious secretions. The tracheal/endotracheal device has several channels. One channel delivers air to a patient's lungs. At least two other channels cooperate to deliver a mist of antiseptic ingredients to an area in the trachea and to suction away the mist and any mucins and secretions. The mist and bodily fluids captured by the suctioning channel are delivered to a collection vessel outside of the trachea.
US10188808B2	Fiber optic distal sensor controlled drug injector A motion-compensated injector system includes a handheld tool having a hollow shaft with a distal end for insertion into tissue of a subject. The system also includes an optical coherence tomography-based optical detection system having an optical fiber with a distal end at a fixed distance from the distal end of the hollow shaft, and an optical sensor to receive a signal from the optical fiber. The system further includes an actuator to move the hollow shaft in an axial direction, and a control unit to control the actuator. The optical detection system can monitor a distance between the distal end of the optical fiber and a reference portion of the tissue of the subject, and the control unit can control the actuator to move the hollow shaft to compensate for relative motion between the handheld tool and the portion of the tissue.
US10188803B2	Disposable safe vein transfusion puncture needle A disposable safe vein transfusion puncture needle comprising a needle head (4), a needle base (3), a needle sheath sleeved on the needle head (4), and a hose (6) communicated with the needle base (3), and further comprising a plurality of slidable components (1, 2) and a plurality of limiting mechanisms (11, 12, 13, 21, 31, 32), wherein the needle base (3) is in a tubular shape, with one end stationary and communicated with the needle head (4) and the other end connected to the hose (6); each of the slidable components (1, 2) is in a tubular shape and has two open ends, the plurality of slidable components (1, 2) are sleeved on one another, the innermost slidable component (1) is movably sleeved onto the needle base (3), and a sum of lengths of the plurality of slidable components (1, 2) in a moving direction is longer than the length of the needle head (4); the limiting mechanisms (11, 12, 13, 21, 31, 32) are disposed on the plurality of slidable components (1, 2) as well as on the needle base (3). By providing a plurality of slidable components (1, 2) sleeved on the needle base (3) in a layered manner, the operating portion length of the disposable safe vein transfusion puncture needle is made shorter, and by unfolding the slidable components (1, 2) layer by layer so as to shield the needle head (4) during use and after use, the safety level is increased and the pain suffered by the patient is alleviated.
US10188802B2	Sheath removal mechanism The disclosure relates to a sheath removal mechanism (15) for removing a protective needle sheath (5) from a medicament container (3), the medicament container (3) arrangeable in an medicament delivery device (1), wherein the sheath removal mechanism (15) comprises a cap (11) attachable to a distal end of the medicament delivery device (1), wherein the cap (11) comprises at least one ledge (11.6) adapted to engage a protective needle sheath (5).
US10188799B2	Autoinjector An autoinjector having a body to receive a reservoir and an actuator sleeve including a contact end and extending inside the body and movable relative to the body between projecting positions and an actuated position. The actuator sleeve is in a first projecting position before actuation of the autoinjector and in a second projecting position after actuation. The actuator sleeve, in the second projecting position, extends axially further out from the body than in the first projecting position and includes an annular zone that, in the first projecting position, is arranged inside the body and in the second projecting position is arranged outside the body. The annular zone includes a visual indicator that the autoinjector has been actuated. Axially adjacent the annular zone the actuator sleeve includes a shoulder, projecting radially outwards relative to the visual indicator, thereby protecting the indicator against contact with the inside of the body.
US10188796B2	Method and system for management of diabetes with a glucose monitor and infusion pump to provide feedback on bolus dosing Described and illustrated is a system for management of diabetes that includes an infusion pump, glucose sensor and controller with a method programmed into the controller. The infusion pump is configured to deliver insulin to a subject. The system provides the user with the ability to understand the effects of bolus insulin dosing upon their glucose levels. Specifically, the system provides a message that must include: (a) the trend of the user's glucose; (b) the recommended bolus; and (c) the actual bolus.
US10188787B2	Apparatus, system and method for fluid delivery A fill adapter system for an infusion pump assembly. The system includes a reusable fill adapter base, the base including a volume control mechanism to adjust an available fill volume of a reservoir of the infusion pump assembly and a pump mechanism configured to pump air into a fluid vial. The system also includes a vial adapter assembly including a first needle configured to penetrate a septum of the fluid vial for fluidly coupling the pump mechanism to the fluid vial and a second needle having a first end configured to penetrate the septum of the fluid vial and a second end configured to penetrate a septum of the reservoir of the infusion pump assembly to allow transfer of fluid from the fluid vial to the reservoir of the infusion pump assembly in response to air being pumped into the fluid vial and a needle carriage adapted to carry the first needle and the second needle, wherein the needle carriage slidably attached to the interior of the vial adapter assembly, wherein the needle carriage adapted to slide from a vial end of the vial adapter to a receptacle end of the vial adapter.
US10188785B1	Vaginal cleansing device The vaginal cleaning device is a lavage device that is adapted for use in personal hygiene. The lavage device is designed to reduce the risk of irritation caused by the inappropriate handling of the lavage device. This is done by eliminating the need to physically handle the dressing associated with the lavage device. The dressing is a sterile absorbent dressing that is contained within a sterile container. The dressing is removed from the sterile container using a plug and port arrangement that inserts an assumedly non-sterile plug into a port that is formed in the center of the dressing. This arrangement separates by distance the non-sterile plug from the sterile surface of the dressing. The lavage device comprises a handle, a dressing, and a sterile container.
US10188782B2	Blood processing filter and blood processing method A blood processing filter comprises an inlet-side flexible container and an outlet-side flexible container that sandwich a filter element, an inlet port, and an outlet port, the filter further comprising: a flow path securing sheet; a first seal portion; and a second seal portion, wherein the flow path securing sheet includes a pair of ribs disposed opposite to each other with the outlet port interposed therebetween, and a slit formed inside of the pair of ribs, and diffusing openings that are disposed outside of the pair of ribs and continuously open from the ribs to the lateral portions of the first seal portion.
US10188781B2	Method of manufacturing heat exchanger and heat exchanger A heat exchanger has a hollow fiber membrane layer comprised of a plurality of hollow fiber membrane conduits each of which has a hollow portion allowing a heat medium to pass therethrough. The conduits are derived by winding a base cord of the hollow fiber membrane onto a cylindrical body. The winding follows a generally helical trajectory around the longitudinal axis of the cylindrical body with a plurality of continuous round trips from the first end to the second end and turning back at each respective end, wherein each round trip completes a number of circumferential revolutions N, wherein N is greater than or equal to one, and wherein N is less than two.
US10188779B1	Implantable pump system having an undulating membrane with improved hydraulic performance An implantable pump system is provided, suitable for use as a left ventricular assist device (LVAD) system, having an implantable pump, a battery, a controller, and a programmer. The implantable pump includes a flexible membrane coupled to an actuator assembly via a skirt that extends toward the inlet of the pump and curves to guide blood toward the outlet. The actuator assembly is magnetically engagable with electromagnetic coils, so that when the electromagnetic coils are energized, the actuator assembly causes wavelike undulations to propagate along the flexible membrane to propel blood from the inlet, across the skirt, and through the outlet of the implantable pump. The controller may be programmed by a programmer to operate at frequencies and duty cycles that mimic physiologic flow rates and pulsatility while operating in an efficient manner that avoids thrombus formation, hemolysis and/or platelet activation.
US10188775B2	Lid for a medical waste fluid collection and disposal system A medical waste fluid collection and disposal system includes a medical waste fluid collection cart including first and second fluid collection canisters. A valve assembly selectively communicates with the canisters and a valve drive system controls the valve assembly. A liquid level sensor is positioned within each of the canisters. A cart processor communicates with the liquid level sensors and the valve drive system. A cart drain line communicates with the valve assembly and a receptacle, a cart flushing line communicates with the valve assembly and the receptacle and a cart data line and a cart power line communicate with the cart processor and the cart receptacle. A station includes a drain pump that communicates with a drainage system and a station drain line, a flushing pump that communicates with a source of washing liquid and a station flushing line and a station processor in communication with the drain and flushing pumps. A station data line communicates with the station processor. A coupler communicates with the station drain line, flushing line and the station data line and a station power line. The station coupler removably engages the cart receptacle so operation of the cart and station components can be coordinated by the processors for drainage and flushing of the cart canisters.
US10188770B2	Dental implant having enhanced early stability and method for manufacturing same A dental implant and a method for manufacturing same which assure early stability and fixation power of an implant by suppressing early osteolysis after an implant procedure, and allowing better bone coherence of the implant surface during an osteogenic period by controlling the speed of bone remodeling.
US10188769B2	Biocompatible substrate for facilitating interconnections between stem cells and target tissues and methods for implanting same Disclosed herein are substrates for cell delivery to target tissues requiring treatment for various diseases that induce cell death, damage or loss of function. The substrates are configured to provide seeded cells, including stem cells, with a structural support that allows interconnection with and transmission of biological signals between the cells and the target tissue.
US10188767B2	Scent presentation method, scent presentation apparatus, and olfaction improving apparatus A scent presentation method is provided that includes generating a random number, determining a presentation condition based on the generated random number, and presenting a scent through pulse ejection based on the determined presentation condition.
US10188766B2	Purified hydrogen peroxide gas microbial control methods and devices The present invention relates to methods and devices for providing microbial control and/or disinfection/remediation of an environment. The methods generally comprise: generating a Purified Hydrogen Peroxide Gas (PHPG) that is substantially free of, e.g., hydration, ozone, plasma species, and/or organic species; and directing the gas comprising primarily PHPG into the environment such that the PHPG acts to provide microbial control and/or disinfection/remediation in the environment, preferably both on surfaces and in the air.
US10188764B2	Apparatus for disinfecting an enclosed space Embodiments of the invention relate generally to disinfection and, more particularly, to methods, devices, and systems for disinfection of a space. In one embodiment, the invention provides a disinfecting system comprising: a disinfecting composition; and a device for producing a fog of the disinfecting composition, the fog comprising liquid droplets having diameters between about 0.5 micron and about 20 microns. In some embodiments, the invention includes a dehumidifying device for removing the fog of the disinfecting composition from the space.
US10188763B2	Apparatus and method for sanitizing stethoscope heads An apparatus for sanitizing a stethoscope head. The apparatus includes a housing, a reservoir disposed within the housing for containing the sanitizing fluid, one or more applicator pads mounted on the housing, and a dispensing valve for dispensing the sanitizing fluid from the reservoir onto the applicator pad.
US10188756B2	Imaging histone deacetylases with a radiotracer using positron emission tomography Disclosed herein are histone deacetylase imaging agents for positron emission tomography and related imaging methods using the histone deacetylase imaging agents. The histone deacetylase imaging agents may be a compound of formula (I): wherein R1 is a moiety including a positron emitter; R2 represents hydrogen, or substituted or unsubstituted alkyl, or substituted or unsubstituted aryl, or substituted or unsubstituted heteroaryl; and n is an integer selected from 0 or 1. In one version of the compound of formula (I), R1 is a moiety including an adamantyl group.
US10188753B1	Method for integrating nanoparticles as part of a hydrogel matrix A nanosensor-containing polymer composition for the monitoring of physiological parameters and a method for making the composition are disclosed. The composition includes a nanosensor disposed in a crosslinked, hydrophilic polymer for transdermal application into an intradermal environment. The method involves forming a mixture including nanosensors and a crosslinked polymer precursor, and subjecting the mixture to conditions suitable for crosslinking the polymer precursor to provide a nanosensor-containing crosslinked polymer.
US10188750B1	Self-replicating cell selective gene delivery compositions, methods, and uses thereof Described herein are cell-selective mRNA constructs that can contain a RNA of interest and one or more miRNA targets. The cell-selective mRNA constructs described herein can be used to express an RNA of interest to a cell in a cell-selective manner.
US10188748B2	Pharmaceutical composition containing a stabilised mRNA optimised for translation in its coding regions The present invention relates to a pharmaceutical composition comprising a modified mRNA that is stabilized by sequence modifications and optimized for translation. The pharmaceutical composition according to the invention is particularly well suited for use as an inoculating agent, as well as a therapeutic agent for tissue regeneration. In addition, a process is described for determining sequence modifications that promote stabilization and translational efficiency of modified mRNA of the invention.
US10188744B2	Amphipathic peptide The present invention is directed to an amphipathic peptide and methods of using the amphipathic peptide for delivering small molecule agents to a cell. Ideally, the amphipathic cell penetrating peptide comprises less than approximately 50 amino acid residues with at least 6 arginine residues, at least 12 Alanine Residues, at least 6 leucine residues, optionally at least one cysteine residue, and at least two but no greater than three glutamic acids wherein the arginine residues are evenly distributed along the length of the peptide; and the peptide has a defined ratio of arginine to negatively charged amino acid residues and a defined ratio of hydrophilic amino acid residues to hydrophobic amino acid residues. The present invention is also directed to a nanoparticle and cell delivery system comprising the amphipathic cell penetrating peptide of the invention. The peptide, nanoparticle or cell delivery system of the invention may be used in therapy. For example, the peptide may be used as a therapeutic agent delivery system, in which the therapeutic agent may include nucleic acids or other small molecules.
US10188741B2	Targeting of innate immune response to tumor site The invention provides microparticles or nanoparticles for treatment of tumors comprising: (i) a targeting agent to the tumor or the tumor environment; and (ii) at least one inducer that stimulates a desired immune response in the tumor environment, leading to tumor apoptosis, wherein components (i) and (ii) are non-covalently or covalently attached to the surface of said microparticles or nanoparticles. The targeting agent is an agent that recognizes and binds to an antigen, a receptor or other molecules found on the surface of tumor cells or in the tumor environment and are preferably antibodies.
US10188740B2	Modified Fc molecules Disclosed is a process for preparing a pharmacologically active compound, in which at least one internal conjugation site of an Fc domain sequence is selected that is amenable to conjugation of an additional functional moiety by a defined conjugation chemistry through the side chain of an amino acid residue at the conjugation site. An appropriate amino acid residue for conjugation may be present in a native Fc domain at the conjugation site or may be added by insertion (i.e., between amino acids in the native Fc domain) or by replacement (i.e., removing amino acids and substituting different amino acids). In the latter case, the number of amino acids added need not correspond to the number of amino acids removed from the previously existing Fc domain. This technology may be used to produce useful compositions of matter and pharmaceutical compositions containing them. A DNA encoding the inventive composition of matter, an expression vector containing the DNA, and a host cell containing the expression vector are also disclosed.
US10188738B2	Formulations useful in the treatment of proliferative diseases affecting the respiratory tract The present application provides a pharmaceutical formulation comprising a folate receptor (FR)-targeting antineoplastic substance or composition, wherein the pharmaceutical formulation is configured for administration by inhalation, wherein the FR-targeting antineoplastic substance or composition is comprised in a nanoparticle and wherein the nanoparticles are comprised in microparticles, and its use in the treatment of a proliferative disease affecting at least part of the respiratory tract. The present application further provides a pharmaceutical formulation comprising an antineoplastic agent and a FR-targeting excipient, for use in the treatment of a proliferative disease affecting at least part of the respiratory tract.
US10188736B2	Surfactant composition The present invention relates to a surfactant composition comprising at least one alkylglycoside having the formula CnGm wherein C is an alkyl group; n is the number of carbon atoms in the alkyl group and is 14 to 24; said alkyl group being unbranched or branched, saturated or unsaturated, derivatized or non-derivatized; G is a saccharide residue containing 5 to 6 carbon atoms; and m is a number from 4 to 20. It further also relates to its use and application in detergents, emulsifying agents, wetting agents, anti-aggregation and stabilizing composition and dispersants comprising the same.
US10188733B2	Vaccines comprising bisphosphonate and methods of use thereof The present invention demonstrates that bisphosphonates have an intrinsic adjuvant activity and directly stimulate B cell antibody secretion. Accordingly, the present invention provides vaccines comprising a bisphosphonate, methods for stimulating an immune response, enhancing the immunogenicicty of an immunogen, and methods of treating an infection, an autoimmune disease, an allergy, and/or a cancer using the same.
US10188732B2	Methods and compositions for inactivating enveloped viruses Aspects of the invention provide therapeutic recombinant protein preparations and methods of preparing therapeutic recombinant protein, which methods include contacting recombinant protein preparations with zwitterionic detergent at or above critical micelle concentration of the detergent.
US10188730B2	Anti-LAG3 antibodies and antigen-binding fragments The present invention includes antibodies and antigen-binding fragments thereof that specifically bind to human or cynomolgous monkey LAGS as well as immunoglobulin chains thereof and polynucleotides encoding the same along with injection devices comprising such antibodies or fragments. Vaccines including such antibodies and fragments as well as compositions comprising the antibodies and fragments (e.g., including anti-PD1 antibodies) are included in the invention. Methods for treating or preventing cancer or infection using such compositions are also provided. In addition, methods for recombinant expression of the antibodies and fragments are part of the present invention.
US10188729B2	Modulation of tumor immunity Methods of treating proliferative disorders are described. In particular, combination treatment with a GITR agonist and a PD-1 antagonist are provided.
US10188728B2	Compositions and methods for treatment of cancer Provided are compositions, methods and kits for treating cancer comprising targeted liposomes comprising a chemotherapy agent and a sensitizer for the chemotherapy agent, and non-targeted liposomes comprising an anti-angiogenic agent. In some embodiments, the targeted liposomes are immunoliposomes. In further embodiments, the immunoliposomes bind to Her-2/neu, and the composition is for treating breast cancer.
US10188726B2	Synthetic hepatitis C polypeptide and methods of making and using same Synthetic representative HCV subtypes, including a 1a and 1b genome, dubbed Bole1a and Bole1b, are provided using an inventive method of Bayesian phylogenetic tree analysis, ancestral sequence reconstruction and covariance analysis. Bole1a branches centrally among 390 full-genome sequences used in its design, a carefully curated 143 sequence full-genome dataset, and separate genomic regions including an independent set of 214 E1E2 sequences from a Baltimore cohort. Bole1a is phylogenetically representative of widely circulating strains. Full genome non-synonymous diversity comparison and 9-mer peptide coverage analysis showed that Bole1a is able to provide more coverage (94% and 78% respectively) than any other sequence in the dataset including H77, a traditional reference sequence. Bole1a also provides unsurpassed epitope coverage when compared to all known T cell epitopes.
US10188724B2	Efficient mucosal vaccination mediated by the neonatal Fc receptor The present invention relates to methods and compositions for enhancing delivery of vaccine antigens to the mucosal epithelium, the composition comprising an antigen from an infectious agent fused with an Fc fragment of an immunoglobulin recognized by the neonatal receptors (FcRn). The composition is effective in eliciting a protective long-term memory T cell immune response against infection at a distant mucosal site.
US10188721B2	Recombinant adenovirus vectored FMDV vaccines and uses thereof The present invention encompasses FMDV vaccines or compositions. The invention encompasses recombinant vectors encoding and expressing FMDV antigens, epitopes or immunogens which can be used to protect animals, in particular ovines, bovines, caprines, or swines, against FMDV.
US10188720B2	Recombinant Marek's disease viruses and uses thereof The present invention relates recombinant viruses and the uses thereof. More particularly, the invention relates to novel recombinant Marek's disease viruses encoding polypeptide(s) of interest, and their use to express or deliver such polypeptides to animals, particularly poultry. The invention is particularly suited to vaccinate poultry against avian pathogens.
US10188719B2	Conjugation of Streptococcal capsular saccharides Three conjugation methods for use with the capsular saccharide of Streptococcus agalactiae. In the first method, reductive amination of oxidized sialic acid residue side chains is used, but the aldehyde groups are first aminated, and then the amine is coupled to a carrier via a linker. In the second method, sialic acid residues and/or N-acetyl-glucosamine residues are de-N-acetylated to give amine groups, and the amine groups are coupled to a carrier protein via a linker. In the third method, linkage is via galactose residues in the capsular saccharide rather than sialic acid residues, which can conveniently be achieved using galactose oxidase.
US10188716B2	Protective antigen complexes with increased stability and uses thereof Immunogenic compositions against Bacillus anthracis comprising a stabilized protective antigen complex are disclosed. The stabilized complex comprises protective antigen protein and capillary morphogenesis protein-2, with the capillary morphogenesis protein-2 being bound to the protective antigen protein along a binding interface. The stabilized protective antigen complex has increased thermal and structural stability, along with resistance to premature proteolytic degradation. Methods of using the same to induce an immunogenic response in a subject against B. anthracis infection are also disclosed.
US10188711B2	Peptide conjugated particles The present invention provides compositions comprising peptide-coupled biodegradable poly(lactide-co-glycolide) (PLG) particles In particular, PLG particles are surface-functionalized to allow for coupling of peptide molecules to the surface of the particles (e.g., for use in eliciting induction of immunological tolerance).
US10188709B2	Compositions and methods for the treatment of phenylketonuria (PKU) The present invention provides compositions for the treatment of phenylketonuria in mammals, as well as methods of preparing said compositions. The present invention also provides methods of treating phenylketonuria using the compositions of the invention.
US10188703B2	Method for treating diabetes mellitus by a composition comprising insulin and a GLP-1/glucagon dual agonist A composition for preventing or treating diabetes mellitus includes insulin and a GLP-1/glucagon dual agonist. The composition can inhibit the weight gain and reduce the danger of hypoglycemia due to the administration of insulin, lower the administration dose and greatly improve the compliance of drugs through a combined administration of a long-acting insulin conjugate and a long-acting GLP-1/glucagon dual agonist conjugate. In addition, the long-acting insulin conjugate and the long-acting GLP-1/glucagon dual agonist conjugate can improve the in vivo sustainability and stability because an insulin and a GLP-1/glucagon dual agonist are linked to the immunoglobulin Fc region via a non-peptidyl linker. A method for preventing or treat diabetes mellitus includes administration of the insulin and a GLP-1/glucagon dual agonist.
US10188697B2	Glycopeptide compositions Solutions comprising a glycopeptide antibiotic, for example Vancomycin, and an amino acid or amino acid derivative such as N-acetyl-Glycine or N-acetyl-D-Alanine are provided. These solutions are stable or stabilized for long-term periods at conditions of normal use and storage, and can be formulated as pharmaceutical solutions for use in subjects. Methods of manufacturing and using these solutions are also provided, as are methods of stabilizing a glycopeptide antibiotic, for example Vancomycin, using amino acids or amino acid derivatives such as N-acetyl-Glycine or N-acetyl-D-Alanine.
US10188694B2	Peptide for skin regeneration or wound treatment and use thereof The present invention relates to a peptide for skin regeneration or wound healing and a use thereof. The novel peptide according to the present invention not only promotes the wound healing by increasing the production amount of collagen in dermal fibroblasts but also has an excellent whitening effect by inhibiting the production amount of melanin and tyrosinase activity of melanoma cells, and consists of peptides having a very small size to minimize side effects according to administration of external substances of very small peptides. As a result, it is expected that the novel peptide can be used as an active substance that can replace existing skin regeneration or would therapeutic agents.
US10188685B2	Use of Lactobacillus plantarum composition for manufacturing anti-fatigue probiotic composition to improve exercise performance The present invention is directed to a use of anti-fatigue probiotic bacteria for improving exercise performance, particularly the fatigue caused by exercise. The anti-fatigue probiotic bacteria increases muscle mass and endurance, decreases blood lactate, ammonia, and creatine kinase concentration, and changes body composition; the said bacteria can be used to improve exercise performance.
US10188683B2	Tissue engineering of lung The present invention relates to compositions comprising a decellularized tissue. The present invention also provides an engineered three dimensional lung tissue exhibiting characteristics of a natural lung tissue. The engineered tissue is useful for the study of lung developmental biology and pathology as well as drug discovery.
US10188680B2	Tumor lysate loaded particles Dendritic cells containing tumor lysate loaded particles are prepared. The dendritic cells present tumor antigens to elicit the Major Histocompatibility Complex class I pathway and can be used as a vaccine to treat cancer, including ocular melanoma.
US10188678B2	Composition comprising cinnamaldehyde and zinc to improve swallowing Compositions comprise an amount of cinnamaldehyde that is orally tolerable, thus avoiding an unpleasant mouth feeling, and also tolerable in the gastrointestinal tract. The amount of cinnamaldehyde is supplemented by zinc, and the combination is effective to promote a swallowing reflex. The composition comprising the combination of cinnamaldehyde and zinc can be used in a method to treat dysphagia and/or prevent aspiration pneumonia from dysphagia. In an embodiment, the composition comprising cinnamaldehyde is administered to a human. The composition comprising cinnamaldehyde may be a medicament, a food product or a supplement to a food product.
US10188676B2	Anti-inflammatory solution The present invention provides a method for preventing or treating an inflammatory response, condition or disease in a mammal comprising administering an effective amount of a dilute stabilised hypochlorite solution to said mammal in need thereof as well as a means for mixing and administering fresh, dilute stabilised hypochlorite solution to the site where it is needed.
US10188675B2	Nutrient composition having lipid metabolism-improving action A nutrient composition contains a cellulose acetate having a total degree of acetyl substitution of 0.4 to 1.1. The cellulose acetate may have a compositional distribution index (CDI) of 2.0 or less, where the CDI is specified by the formula: CDI=(Measured value of half height width of chemical composition)/(Theoretical value of half height width of chemical composition) where the measured value of half height width of chemical composition represents the half height width of chemical composition determined by HPLC analysis of a cellulose acetate propionate prepared by propionylating all residual hydroxy groups of the cellulose acetate (sample); and the theoretical value of half height width of chemical composition=2.35482√{square root over (3DPw(DS/3)*(1−DS/3))}/DPw [Math. 1] where DS is the total degree of acetyl substitution; and DPw is a weight-average degree of polymerization determined by a GPC-light scattering method using a cellulose acetate propionate prepared by propionylating all residual hydroxy groups of the cellulose acetate (sample).
US10188674B2	Parenteral formulations for administering macrolide antibiotics Pharmaceutical compositions adapted for the parenteral administration, including intravenous administration, of triazole containing macrolide antibiotics, and methods for their use in the treatment of bacterial, protozoal, and other infections are described herein.
US10188668B2	Cancer drug and uses A pharmaceutical composition comprising a cancer therapeutic that is capable of inhibiting and/or reducing the ability of a cancer cell to take up and utilize glucose or other energy source, a lipid or other building block of a cell membrane or organelle, and/or cholesterol. The pharmaceutical composition can comprise one or more cancer therapeutics that can be administered individually or in combination to an individual.
US10188667B2	Pharmaceutical compositions and methods of use of 4-pregenen-11β-17-21-triol-3,20-dione derivatives The present invention relates to pharmaceutical compositions comprising 4-pregenen-11β-17-21-triol-3,20-dione derivatives, and their use as pharmaceuticals as modulators of the glucocorticoid receptors (GR) and/or the mineralocorticoid receptors (MR). The invention relates specifically to the use of these compounds and their pharmaceutical compositions to treat ocular conditions associated with the glucocorticoid receptors (GR) and/or the mineralocorticoid receptors (MR).
US10188661B2	Topical dosage regimen Described herein is a novel dosage regimen, and related uses and methods, for a prostaglandin FP receptor agonist (PFPRA) compound topically administered to the skin. The dosage regimen is useful for reduction of subcutaneous fat, for example, in patients who suffer from local excesses of subcutaneous fat. A particular advantage of the dosage regimen is the ability to reduce composition exposure and thereby promote convenience and comfort, while maintaining the desired exposure and therapeutic effect in subcutaneous fat. Further provided are kits according to the novel dosage regimen, comprising a PFPRA composition and instructions for use.
US10188659B2	IGF-1R signaling pathway inhibitors useful in the treatment of neurodegenerative diseases The present invention provides compounds acting as Insulin/IGF signaling modulators useful in the treatment of neurodegenerative diseases and disorders. The invention provides pharmaceutical compositions including such compounds, and methods of using these compounds and compositions for the treatment of neurodegenerative diseases, in particular neurodegenerative diseases caused by proteotoxicity such as Alzheimer's disease.
US10188655B2	Liquid pharmaceutical composition comprising pemetrexed The present invention relates to a liquid pharmaceutical composition suitable for parenteral administration comprising: a) pemetrexed diacid; b) at least one organic amine; c) at least one antioxidant; d) 10-200 mg/ml of propylene glycol; and e) one or more parenteral solvents, wherein the preparation thereof is conducted in an atmosphere of inert gas and wherein the organic amine(s) is present in an amount sufficient to reach a pH of the composition in the range from 8.3 to 9.1 The invention further relates to the use of said liquid pharmaceutical composition as medicament in the treatment of malignant pleural mesothelioma and non-small cell lung cancer.
US10188652B2	Compositions and methods for treating insomnia In the present invention, compound such as (1R,2S)-2-(((2,4-dimethylpyrimidin-5-yl)oxy)methyl)-2-(3-fluorophenyl)-N-(5-fluoropyridin-2-yl) cyclopropanecarboxamide have been found to be potent orexin receptor antagonists, and may be useful in the treatment of sleep disorders such as insomnia, as well as for other therapeutic uses.
US10188650B2	Treatment of neurological disorders Provided herein is technology relating to treatment of neurological disorders and particularly, but not exclusively, to methods and compositions for treating neurological disorders caused by aberrant and/or dysregulated expression and/or activity of Down syndrome cell adhesion molecule (Dscam) with agents that modulate physiological components associated with the functions and/or dysfunctions of Dscam, e.g., physiological components that can be modulated to counteract aberrant Dscam expression and/or activity such as Abelson murine leukemia viral oncogene homolog 1 kinase.

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