| Document | Document Title |
|---|---|
| US08884298B2 |
Semiconductor device having embedded strain-inducing pattern and method of forming the same
A semiconductor device can include an active region having a fin portion providing a channel region between opposing source and drain regions. A gate electrode can cross over the channel region between the opposing source and drain regions and first and second strain inducing structures can be on opposing sides of the gate electrode and can be configured to induce strain on the channel region, where each of the first and second strain inducing structures including a respective facing side having a pair of {111} crystallographically oriented facets. |
| US08884295B2 |
Thin film transistor including an active layer pattern, method of manufacturing the same, and organic light emitting display apparatus
A thin film transistor (TFT) having an active layer pattern, the active layer pattern including a first active layer pattern extending in a first direction; a second active layer pattern extending in the first direction and parallel to the first active layer pattern; and a third active layer pattern connecting a first end of the first active layer pattern to a first end of the second active layer pattern. |
| US08884294B2 |
Semiconductor device and method for manufacturing the same
An object of an embodiment of the present invention is to manufacture a highly-reliable semiconductor device comprising a transistor including an oxide semiconductor, in which change of electrical characteristics is small. In the transistor including an oxide semiconductor, oxygen-excess silicon oxide (SiOX (X>2)) is used for a base insulating layer of a top-gate structure or for a protective insulating layer of a bottom-gate structure. By using the oxygen-excess silicon oxide, oxygen is discharged from the insulating layer, and oxygen deficiency of an oxide semiconductor layer and the interface state density between the oxide semiconductor layer and the base insulating layer or the protective insulating layer can be reduced, so that the highly-reliable semiconductor device in which change of electrical characteristics is small can be manufactured. |
| US08884290B2 |
Thin film transistor array panel, display device including the panel, and method for manufacturing the display device
A thin film transistor array panel, a display device including the thin film transistor array panel, and a method for manufacturing the display device. The thin film transistor array panel includes a substrate having first and second surfaces, a first thin film form formed on the first surface and including a first electrode, and a second thin film form formed on the second surface and including a second electrode, to thereby improve the viewing angle and contrast ratio of the display device. |
| US08884288B1 |
Semiconductor structure with means for testing metal-insulator-metal capacitors
The present invention provides a semiconductor structure for testing MIM capacitors. The semiconductor structure comprises: a first metal layer comprising at least a first circuit area and a second circuit area; a second metal layer located below the first metal layer with a first dielectric layer lying therebetween and connected with the second circuit area; a top plate located within the first dielectric layer closer to the first metal layer and connected with the first circuit area; a bottom plate located within the first dielectric layer closer to the second metal layer and separated from the top plate with an insulation layer therebetween and connected with the second circuit area. The second metal layer is connected with the substrate through a first electric pathway so as to form a second electric pathway from the top plate to the substrate when an electric leakage region exists in the insulation layer. |
| US08884285B2 |
Multifunctional zinc oxide nano-structure-based circuit building blocks for re-configurable electronics and optoelectronics
A vertically integrated reconfigurable and programmable diode/memory resistor (1D1R) and thin film transistor/memory resistor (1T1R) structures built on substrates are disclosed. |
| US08884283B2 |
Memory semiconductor device having aligned side surfaces
An object is to provide a semiconductor device having a novel structure with a high degree of integration. A semiconductor device includes a semiconductor layer having a channel formation region, a source electrode and a drain electrode electrically connected to the channel formation region, a gate electrode overlapping with the channel formation region, and a gate insulating layer between the channel formation region and the gate electrode. A portion of a side surface of the gate insulating layer and a portion of a side surface of the source electrode or the drain electrode are substantially aligned with each other when seen from a planar direction. |
| US08884278B2 |
Organic electroluminescent device
According to one embodiment, an organic electroluminescence device includes a first electrode, a second electrode, a first organic layer and a second organic layer. The second electrode includes a metal. The first organic layer is provided between the first electrode and the second electrode. The first organic layer is configured to emit light. The second organic layer is provided between the first organic layer and the second electrode. A refractive index of the second organic layer in a thickness direction for the light is lower than a refractive index of the first organic layer for the light. |
| US08884272B2 |
Amorphous oxide semiconductor material, field-effect transistor, and display device
There is provided an amorphous oxide semiconductor material including an amorphous oxide semiconductor including In, Ga and Zn, wherein when In:Ga:Zn=a:b:c denotes an element composition ratio of the oxide semiconductor, the element composition ratio is defined by the range of a+b=2 and b<2 and c<4b−3.2 and c>−5b+8 and 1≦c≦2. |
| US08884271B2 |
Photodetection device
The present invention relates to a photodetector for detecting an infrared-light emission having a given wavelength (λ) comprising a multilayer with: a layer (11) of a partially absorbent semiconductor; a spacer layer (12) made of a material that is transparent to said wavelength; and a structured metallic mirror (13), the distance (g) between the top of said mirror and said spacer layer being smaller than λ and said mirror comprising a network of holes defining an array of metallic reliefs with a pitch P of between 0.5 λ/nSC and 1.5 λ/nSC, where nSC is the real part of the refractive index of the semiconductor, a relief width L of between 9P/10 and P/2 and a hole depth h of between λ/100 and λ/15. |
| US08884268B2 |
Diffusion barrier layer for group III nitride on silicon substrate
The present disclosure is directed to an integrated circuit and its formation. In some embodiments, the integrated circuit includes a diffusion barrier layer. The diffusion barrier layer can be arranged to prevent diffusion of the Si and O2 from a Si substrate into a Group III nitride layer. The diffusion barrier layer can comprise Al2O3. In some embodiments, the integrated circuit further comprises a lattice-matching structure disposed between the silicon substrate and a Group III nitride layer. |
| US08884261B2 |
Device switching using layered device structure
A resistive switching device. The device includes a first electrode comprising a first metal material overlying the first dielectric material and a switching material comprising an amorphous silicon material. The device includes a second electrode comprising at least a second metal material. In a specific embodiment, the device includes a buffer material disposed between the first electrode and the switching material. The buffer material provides a blocking region between the switching material and the first electrode so that the blocking region is substantially free from metal particles from the second metal material when a first voltage is applied to the second electrode. |
| US08884257B2 |
Chamber apparatus and extreme ultraviolet light generation system
A chamber apparatus, which may be used with an external apparatus having an obscuration region, may include: a chamber in which EUV light is generated; a collector mirror having a first through-hole formed in a region aside from the center thereof and configured to collect the EUV light generated inside the chamber, the collector mirror being positioned such that the first through-hole is located in a region substantially corresponding to the obscuration region; and an etching gas supply unit provided in the first through-hole and configured to supply an etching gas into the chamber. |
| US08884256B2 |
Septum magnet and particle beam therapy system
A septum magnet includes a yoke that can be separated at the approximately center portion thereof in the axis direction; a septum coil; a return coil; and a vacuum duct that is inserted between the septum coil and the return coil. The septum coil is formed in such a way as to be able to be separated into a first portion and a second portion in response to separation of the yoke; and in a space between the septum coil and the vacuum duct, there is provided an auxiliary coil, in two portions of which, corresponding to the first portion and the second portion of the septum coil, electric currents flow in opposite direction to each other in a circumferential direction. |
| US08884255B2 |
Data path for lithography apparatus
A maskless charged particle lithography system comprises an electron-optical column and a data path. The column includes a blanker array including blanker elements. The data path comprises a preprocessing system, transmission channels, and a pattern streaming system. The lithography system is configured for exposing a target field in two passes by allocating a first beamlet subset for exposing a first field subset during a first pass and a second beamlet subset for exposing a second field subset during a second pass. A first beam selector selects a first pattern data subset containing exposure data for the first beamlet subset and a second pattern data subset containing exposure data for the second beamlet subset. Second beam selectors connect transmission channels assigned for transmitting the first pattern data subset to a first blanker elements subset, and transmission channels assigned for transmitting the second pattern data subset to a second blanker elements subset. |
| US08884250B2 |
Biofuel degradation sensor based on fluorescence measurements
A sensor that detects a fuel property of a mixed fuel of a biofuel and a hydrocarbon fuel includes: a light emitting device that emits light with a wavelength of 250 nm to 400 nm onto the mixed fuel; and a light receiving device that receives light emitted by the mixed fuel under the effect of light from the light emitting device and generates an output corresponding to the received light. When the fuel property is determined, in a case where the mixed fuel is irradiated by light with a predetermined wavelength generated due to voltage application to the light emitting device, the light emitted by the mixed fuel is detected by the light receiving device. The fuel property of the mixed fuel is detected according to the detected light. |
| US08884248B2 |
Forming a vitrified sample for electron microscopy
The invention relates to a method of forming a vitrified sample on a sample holder for inspection in an electron microscope. It is known to spray a solution on a grid and then immerse the grid in a cryogenic liquid, such as ethane or liquid nitrogen. The invention proposes to spray small droplets of the liquid on a cryogenic surface, such as a grid or a sample holder in vacuum. The liquid forms vitrified sample material when hitting the surface due to the low temperature of the grid or sample holder.A lamella may be excavated from the thus formed sample material, to be studied in a TEM, or the vitrified sample material may be directly observed in a SEM. In an embodiment the material may be sprayed on a cryogenic liquid, to be scooped from the liquid and placed on a grid. |
| US08884246B2 |
Charged particle optical system and scribing apparatus
An optical system for a charged particle includes a first member though which a charged particle beam is transmitted and a second member to control optically the charged particle beam transmitted through the first member. The second member has a fixing portion fixed to the first member. A slit is arranged between a part of the second member and the fixing portion to separate the part of the second member from the fixing portion, such that the part of the second member is a cantilever beam structure pivotal in relation to the fixing portion. |
| US08884243B2 |
Radiation phantom
A radiation phantom device includes at least one movement device for moving at least one first sub-region of the radiation phantom device. The radiation phantom device has, at least one of at times or in regions, radiation properties which are in conformity with a radiation phantom model. |
| US08884242B2 |
Method and system for analyzing physical conditions using digital images
Systems and methods are provided for analyzing conditions associated with a physical feature using digital images. The method comprises acquiring a white-light image and an ultraviolet (“UV”) image of at least a portion of a body surface, such as a person's face, each of the white-light and UV images including a plurality of pixels and each pixel in the UV image corresponding to a respective pixel in the white-light image. The method further comprises identifying feature pixels in the white-light and UV images, and obtaining results associated with at least one physical condition using information in the feature pixels in the first white light and UV images. |
| US08884239B2 |
High resolution medical imaging detector
A detector arrangement providing imaging information at the edge of the scintillator is provided. The detector arrangement provides complete information and improved spatial resolution. SiPMs can be used in place of PMTs in order to provide the geometrical coverage of the scintillator and improved spatial resolution. With such detector arrangements, the spatial resolution can be under 2 mm. Furthermore, the overall thickness of the detector can be substantially reduced and depth of interaction resolution is also improved. |
| US08884235B2 |
System and method for collimation in diagnostic imaging systems
A system and method for collimation in diagnostic imaging systems is provided. One collimator includes a plurality of parallel hole segments and a plurality of collimator bores within each of the plurality of parallel hole segments. Additionally, all of the plurality of collimator bores in at least one of the plurality of parallel hole segments have a first pointing direction and all of the plurality of collimator bores in at least one other of the plurality of parallel hole segments have a second pointing direction, wherein the plurality of parallel hole segments are arranged in a fanbeam collimation configuration. Further, the first pointing direction is different than the second pointing direction. |
| US08884234B2 |
Portable directional device for locating neutron emitting sources
An apparatus for determining a direction of travel of a neutron emitted from a source includes: a chamber containing (i) nuclei that recoil upon interaction with an incoming neutron and (ii) atoms capable of being ionized by the recoiled nuclei thereby releasing electrons; an electron-interaction material disposed at the chamber and configured to receive electrons released by the ionized atoms and to emit photons upon the interaction with the received electrons; an imager configured to form an image of photons emitted by the electron-interaction material, wherein the image comprises a path having the direction of travel of the incoming neutron; and an orientation sensor configured to sense an orientation of the imager in order to relate the direction of travel of the incoming neutron to the orientation of the imager. |
| US08884233B2 |
Gamma ray spectroscopy employing divalent europium-doped alkaline earth halides and digital readout for accurate histogramming
A scintillator radiation detector system according to one embodiment includes a scintillator; and a processing device for processing pulse traces corresponding to light pulses from the scintillator, wherein pulse digitization is used to improve energy resolution of the system. A scintillator radiation detector system according to another embodiment includes a processing device for fitting digitized scintillation waveforms to an algorithm based on identifying rise and decay times and performing a direct integration of fit parameters. A method according to yet another embodiment includes processing pulse traces corresponding to light pulses from a scintillator, wherein pulse digitization is used to improve energy resolution of the system. A method in a further embodiment includes fitting digitized scintillation waveforms to an algorithm based on identifying rise and decay times; and performing a direct integration of fit parameters. Additional systems and methods are also presented. |
| US08884229B2 |
Passive infrared range finding proximity detector
Apparatus and methods for a passive range finding proximity detector include a sensor element configured to detect infrared radiation emitted by objects within a detection area. The sensor is configured to detect the temperature, relative size, relative distance, speed or direction of movement of an object from the sensor. The sensor is configured to set parameters for a controlled object based upon the detected size, temperature and/or proximity, speed or direction of an object in relation to one or more size thresholds, temperature thresholds, and/or proximity, speed or direction thresholds. |
| US08884226B2 |
OCT device
A photodetector of an OCT device is provided with: a silicon substrate comprised of a semiconductor of a first conductivity type, having a first principal surface and a second principal surface opposed to each other, and having a semiconductor region of a second conductivity type formed on the first principal surface side; and charge transfer electrodes provided on the first principal surface and transferring generated charges. In the silicon substrate, an accumulation layer of the first conductivity type having a higher impurity concentration than the silicon substrate is formed on the second principal surface side, and an irregular asperity is formed in a region opposed to at least the semiconductor region, in the second principal surface. The region in which the irregular asperity is formed on the second principal surface of the silicon substrate is optically exposed. |
| US08884225B2 |
Sample observing device and sample observing method
An electron beam inspection device observes a sample by irradiating the sample set on a stage with electron beams and detecting the electron beams from the sample. The electron beam inspection device has one electron column which irradiates the sample with the electron beams, and detects the electron beams from the sample. In this one electron column, a plurality of electron beam irradiation detecting systems are formed which each form electron beam paths in which the electron beams with which the sample is irradiated and the electron beams from the sample pass. The electron beam inspection device inspects the sample by simultaneously using a plurality of electron beam irradiation detecting systems and simultaneously irradiating the sample with the plurality of electron beams. |
| US08884222B2 |
Mount for a scanning probe sensor package, scanning probe sensor package, scanning probe microscope and method of mounting or dismounting a scanning probe sensor package
A mount for a scanning probe sensor package (27) comprises a support structure (1, 5) defining a plane within the mount and at least one movable snap joint element (9) designed for interacting with a respective counterpart (43) in a scanning probe sensor package (27). The snap joint element (9) is movable to a first position in which it exerts a force on a mounted scanning probe sensor package (27) so as to force said scanning probe sensor package (27) in a normal direction of said plane towards the support structure (1,5) and to a second position in which it allows a scanning probe sensor package (27) to be mounted to or dismounted from the support structure (1, 5) along normal direction of said plane. |
| US08884221B2 |
High performance ion mobility spectrometer apparatus and methods
An ion mobility spectrometer wherein ions are separated along a drift axis while providing a drift gas flow in a direction that is substantially neither in the direction of the drift axis nor opposite to the drift axis. An ion mobility spectrometer and operation methods use a cross-directional gas flow in a drift tube and/or a segmented drift tube for pre-separation. |
| US08884217B2 |
Multimode cells and methods of using them
A mass spectrometer system is provided that is configurable for operation in both a Kinetic Energy Discrimination (KED) and Dynamic Reaction Cell (DRC). A pressurized or collision cell included in the mass spectrometer encloses a quadrupole and is coupled to a source of both inert and reactive gas. To operate in the KED mode, the collision cell can be filled with a quantity of the inert gas and an energy barrier formed between the collision cell and a downstream mass analyzer. Interferer ions collided with the inert gas can lose on average more energy relative to analyte ions of the same mass to charge ratio and can thus be trapped by the energy barrier in greater proportions. To operate instead in the DRC mode, the collision cell can be filled with a quantity of gas that is reactive with the interferer ions only. Mass filtering of the product ions can then transmit proportionally more of the analyte ions to the downstream mass analyzer. A mode controller coordinates the two modes of operation. |
| US08884214B2 |
Methods of using halogenated peptides as internal standards for liquid chromatography-mass spectrometry
Methods of using halogenated peptides as internal standards for liquid chromatography-mass spectrometry, and novel halogenated peptides useful for the same, are disclosed. In particular, methods of using halogenated peptides as internal standards in proteomic analyzes, as well as methods of using halogenated peptides to conduct quality control assessments of and/or to calibrate liquid chromatography-mass spectrometry systems are disclosed. |
| US08884213B2 |
Energy correction for one-to-one coupled radiation detectors having non-linear sensors
Systems and methods for correcting output signals from non-linear photosensors, specifically silicon photomultipliers (SiPMs). SiPMs are used in a PET detector to readout light emissions from LSO scintillator crystals. The non-linear output of the SiPM can distort and compress the energy spectrum which is crucial in PET imaging. The non-linearity effect for inter-crystal scattered events can place an energy event outside of the PET detector energy window, resulting in a rejected event. Systems and methods to correct the SiPM non-linearity for inter-crystal scattered events, so as to be able to obtain the proper energy event and produce an accurate medical image, are disclosed. |
| US08884211B2 |
Confocal imaging methods and apparatus
The invention provides imaging apparatus and methods useful for obtaining a high resolution image of a sample at rapid scan rates. A rectangular detector array having a horizontal dimension that is longer than the vertical dimension can be used along with imaging optics positioned to direct a rectangular image of a portion of a sample to the rectangular detector array. A scanning device can be configured to scan the sample in a scan-axis dimension, wherein the vertical dimension for the rectangular detector array and the shorter of the two rectangular dimensions for the image are in the scan-axis dimension, and wherein the vertical dimension for the rectangular detector array is short enough to achieve confocality in a single axis. |
| US08884208B2 |
Light receiving circuit
According to one embodiment, a light receiving circuit having a trans-impedance amplifier and an output circuit is provided. The trans-impedance amplifier includes a photodiode, a feedback resistor and a first transistor having a channel of a first conductive type. The photodiode converts an optical signal into an electrical signal. Ends of the feedback resistor are connected respectively to the photodiode and a node. A gate of the first transistor receives the electrical signal from the photodiode. A signal corresponding to a signal from a drain of the first transistor is output to the node. The output circuit includes a second transistor having a channel of the first conductive type, and generates an output signal from a drain of the second transistor. A gate of the second transistor is connected to the node. |
| US08884205B2 |
Low consumption matrix sensor
An image matrix sensor having a plurality of individual detection structures associated with respective pixels, each individual detection structure including a photodiode having at least one solar cell mode operating range, a first amplifier stage constantly supplied with power and receiving, as an input, a voltage dependent on the voltage of the photodiode which falls within said range; and a second amplifier stage linked to the output of the first amplifier stage and supplied with power in a different manner according to whether or not the first amplifier stage is read. |
| US08884200B2 |
Electromagnetically shielded inductor assembly
An openable induction coil is provided. An electromagnetically shielded inductor assembly can be formed from the openable induction coil and an electromagnetically shielded enclosure into which the coil can be inserted. The induction coil can be pivoted open while in the shielding enclosure without complete disassembly of the enclosure. In some examples of the invention, a dynamic “curtain” of a gas is injected through spaces between opening portions of the coil and adjacent sections of the shielding enclosure, and into the interior of the induction furnace formed by the openable induction coil when it is in the closed position. |
| US08884194B2 |
Heating plate with planar heater zones for semiconductor processing
A heating plate of a semiconductor substrate support for supporting a semiconductor substrate in a plasma processing chamber includes a first layer with an array of heater zones operable to tune a spatial temperature profile on the semiconductor substrate, and a second layer with one or more primary heaters to provide mean temperature control of the semiconductor substrate. The heating plate can be incorporated in a substrate support wherein a switching device independently supplies power to each one of the heater zones to provide time-averaged power to each of the heater zones by time divisional multiplexing of the switches. |
| US08884190B2 |
Vertical-position welding method
A pair of thick steel plates are set up side by side such that an I groove with a narrow gap is formed between the facing edges of the plates, and a welding wire projecting from a welding torch of an arc welding unit with a constant voltage characteristic is inserted into the I groove obliquely from above with respect to the thickness direction of the plates. The welding torch is moved vertically while the distal end of the welding wire is caused to reciprocate inside the I groove in the thickness direction. At this time, the wire feed rate Vf is varied and also the extension L of the welding wire is increased or decreased so as to keep welding current Iw at a target value. Further, the wire feed rate Vf is subjected to incremental/decremental correction according to the moving direction of the torch. |
| US08884187B2 |
Welding observation apparatus
A welding observation apparatus is provided to use partial darkening by a telecentric optical system and a photochromic filter (PCF) as an optical system for filtering light emission from arc discharge in order to verify the welding condition under the welding arc discharge, without forming an image on the PCF, so that light reducing performance can be secured even if a focus shifts from on the PCF, with satisfactory monitoring of welding condition.The welding observation apparatus comprises: an arc welding unit 8; an objective optical system (1, 2) for concentrating light from the arc welding unit 8; a telecentric optical system 3 for guiding the light concentrated by the objective optical system (1, 2); a PCF 4 for illuminating with the light guided by the telecentric optical system 3; and a solid state imaging device 9 for receiving the light passing through the PCF 4, wherein the light from the arc welding unit 8 is partial-darkened by the PCF 4. |
| US08884186B2 |
Method and device use to produce a set of control data for producing products by free-form sintering and/or melting, in addition to a device for the production thereof
A method and apparatus used to produce control data for building up a product layer by layer using freeform sintering and/or melting with a high energy beam. The correspondingly controlled apparatus for production of the products is further disclosed. The high energy beam is applied under the guidance of the control data set. Before beginning the freeform sintering and/or freeform melting, a compensation data set and/or a compensation function to compensate for manufacturing related effects caused by the sintering and/or melting is determined. The control data set is based upon a product target geometry data set and the compensation data set and/or the compensation function. |
| US08884185B2 |
Method and apparatus for laser marking objects
Embodiments of the present invention comprise an apparatus for laser marking individual objects with indicia at a marking station wherein a predetermined window exists during which each object can be marked as the objects are conveyed along at least one path at a predetermined speed, the apparatus comprising, at least first and second lasers positioned adjacent one or more paths configured to direct a laser beam onto the objects to mark the same with indicia as the objects pass through the marking station, with each of the first and second lasers marking alternate following objects as they pass through the marking station. |
| US08884181B2 |
Method of generating low-energy secondary electrons for applications in biological sciences, radiochemistry, and chemistry of polymers and physics of radiotherapy
The present disclosure relates to a method and a system for generating low-energy electrons in a biological material. The biological material is held in position by a support. Laser beam pulses are directed by a focusing mechanism toward a region of interest within the biological material. This generates filaments of low-energy electrons within the region of interest. The method and system may be used for radiotherapy, radiochemistry, sterilization, nanoparticle coating, nanoparticle generation, and like uses. |
| US08884180B2 |
Over-voltage protection during arc recovery for plasma-chamber power supplies
A system and method for managing power delivered to a processing chamber is described. In one embodiment current is drawn away from the plasma processing chamber while initiating an application of power to the plasma processing chamber during an initial period of time, the amount of current being drawn away decreasing during the initial period of time so as to increase the amount of power applied to the plasma processing chamber during the initial period of time. |
| US08884179B2 |
Torch flow regulation using nozzle features
A nozzle for a plasma arc torch includes a body having a first end and a second end. The nozzle also includes a plasma exit orifice located at the first end of the body. A flange is located at the second end of the body. The flange is adapted to mate with a corresponding consumable. The flange is configured to selectively block at least one gas passage in the corresponding consumable to establish a gas flow relative to the nozzle body. |
| US08884178B2 |
Methods and apparatus for igniting and sustaining plasma
Atmospheric inductively coupled plasma torch comprising a vessel within which the plasma is generated and a coil wound around the periphery of the vessel. The coil has at least two spaced-apart winding layers. The coil is constructed such that all winding layers of a given multi-turn is wound before an adjacent multi-turn is wound. A first end of the coil is coupled to ground, and a second end of the coil is coupled to receive a RF driver signal that is configured to ignite the plasma to facilitate processing. |
| US08884175B2 |
Self-locking switch
A self-locking switch including a button sub-assembly and a housing sub-assembly. The button sub-assembly includes at least one button with a tab extending from a lower surface at a first end and at least one shaft engagement point on the lower surface at a second end, and a bracket comprising a first end and a second end with a rotation shaft at the second end. The bracket is rotatably connected to the button. The housing sub-assembly includes a switch housing having engagement points, and a switching mechanism in the housing. The button sub-assembly and the housing sub-assembly are joined together by engaging the tab of the button and the first and second ends of the bracket to corresponding engagement points on the switch housing and the engagement points are not accessible from outside the self-locking switch after the button sub-assembly and the housing sub-assembly are assembled together. |
| US08884174B2 |
Locally illuminated keycap
A locally illuminated keycap is located in a keyboard. The keyboard includes a lighting unit to project light to the keycap. The keycap includes at least one top edge to form an opaque press surface, at least one bottom edge located below the press surface to form a light incident surface to receive light, and at least one transparent light emitting surface connecting to the top edge and bottom edge to emit light. The press surface and light emitting surface form an inclined angle between them greater than 90 degrees. The press surface, light incident surface and light emitting surface jointly form a light retaining zone. Light generated by the lighting unit projects to the light incident surface and enters the light retaining zone, and is masked by the opaque press surface to emit locally through the transparent light emitting surface. |
| US08884171B2 |
Pen transcription system with improved noise rejection
A transcription module having a mounting unit, acoustical receivers and an EM detector is disclosed. The mounting unit is adapted for positioning the transcription module over a work surface. First and second acoustical receivers are attached to the mounting unit. Each acoustical receiver includes a microphone positioned over a corresponding location on the work surface. Each microphone views the work surface at the corresponding location and is configured to receive acoustical signals from an input device operating over the work surface at another location. The EM detector detects an EM signal that is synchronized with the acoustical signals. |
| US08884169B2 |
Circuit assembly
A circuit assembly that includes a planar lead frame formed of electrically conductive material having a first thickness. The lead frame is configured to define a routing plane and a plurality of coplanar sections in the routing plane. The circuit assembly also includes a top-side terminal formed of electrically conductive material having a second thickness independent of the first thickness. The top-side terminal is configured to be inserted into a hole defined in a section and form an electrical connection to the section, wherein the top-side terminal protrudes from the routing plane. |
| US08884161B1 |
Non-metallic electrical floor box
An electrical outlet box for installing in a hole defined in a pre-existing, finished floor of a building. The outlet box comprises a box portion, a backplate, and a cover plate. The box portion comprises a first pair of opposing walls, a second pair of opposing walls, a bottom wall, and a mounting flange. Top edges of each wall of the first and second pairs of opposing walls define an open top end of the box portion. The bottom wall is affixed to bottom edges of each wall of the first and second pairs of opposing walls, thereby defining a cavity within the first and second pairs of opposing walls and the bottom wall. The cavity is adapted for receiving an electrical outlet. The mounting flange surrounds the open top end and is adapted for sitting flush against the installed floor when the outlet box is mounted in the hole. |
| US08884157B2 |
Method for manufacturing optoelectronic devices
A method for manufacturing an optoelectronic device includes steps of: providing an optoelectronic structure; forming a first metal contact layer having a pattern on the upper surface of the optoelectronic structure; forming a dielectric layer on the first metal contact layer and the optoelectronic structure; removing the dielectric layer on the first metal contact layer; and forming an electrode structure on the first metal contact layer. |
| US08884153B2 |
Photoelectric conversion element and interconnector-equipped photoelectric conversion element
Provided are a photoelectric conversion element and an interconnector-equipped photoelectric conversion element, the photoelectric conversion element including: a photoelectric conversion layer having at least one pn junction; a first electrode pad provided on a surface of the photoelectric conversion layer; a second electrode pad provided on a surface different from the surface of the photoelectric conversion layer on which the first electrode pad is provided; and a third electrode provided on a surface of the photoelectric conversion layer opposite to the surface on which the second electrode pad is provided, wherein at least one of surface shapes of the first electrode pad and the second electrode pad is a polygon in which any internal angle is an obtuse angle or a shape having no corner. |
| US08884152B2 |
Thermoelectric semiconductor material, thermoelectric semiconductor element using thermoelectric semiconductor material, thermoelectric module using thermoelectric semiconductor element and manufacturing method for same
A metal mixture is prepared, in which an excess amount of Te is added to a (Bi—Sb)2Te3 based composition. After melting the metal mixture, the molten metal is solidified on a surface of a cooling roll of which the circumferential velocity is no higher than 5 m/sec, so as to have a thickness of no less than 30 μm. Thus, a plate shaped raw thermoelectric semiconductor materials 10 are manufactured, in which Te rich phases are microscopically dispersed in complex compound semiconductor phases, and extending directions of C face of most of crystal grains are uniformly oriented. The raw thermoelectric semiconductor materials 10 are layered in the direction of the plate thickness. And the layered body is solidified and formed to form a compact 12. After that, the compact 12 is plastically deformed in such a manner that a shear force is applied in a uniaxial direction that is approximately parallel to the main layering direction of the raw thermoelectric semiconductor materials 10. As a result, a thermoelectric semiconductor 17 having crystal orientation in which extending direction of C face and the direction of c-axis of the hexagonal structure are approximately aligned. As a result, the crystalline orientation is improved, and the thermoelectric Figure-of-Merit is increased. |
| US08884151B1 |
Electronic drum pad
The present disclosure illustrates an electronic drum pad comprising: a base body having a frame rim protruding upwardly at an edge part of an upper surface thereof, and having a frame dike protruding downwardly at an edge part of a lower surface thereof, and the frame dike buckled and fastened on a drum frame of a jazz drum; a striking region portion arranged in a center of the base body; a first trigger configured for sensing the vibration of the striking region portion, arranged inside a first electronic component groove of the base body, and located in a bottom part of the striking region portion; a second trigger configured for sensing the vibration of the frame rim, arranged inside a second electronic component groove of the base body, and the second electronic component groove being close to the frame rim. |
| US08884150B2 |
Microphone array transducer for acoustical musical instrument
A dipole microphone array is provided for an acoustical stringed instrument of the type having a body and a plurality of strings spaced from the body. The array includes a plurality of microphone assemblies each having a first and a second microphone. The second microphone is out of phase with the first microphone so as to provide a dipole microphone assembly. Each of the microphone assemblies is mounted on the body of the instrument in close proximity to one of the strings. |
| US08884135B2 |
Plants and seeds of hybrid corn variety CH508984
According to the invention, there is provided seed and plants of the hybrid corn variety designated CH508984. The invention thus relates to the plants, seeds and tissue cultures of the variety CH508984, and to methods for producing a corn plant produced by crossing a corn plant of variety CH508984 with itself or with another corn plant, such as a plant of another variety. The invention further relates to genetic complements of plants of variety CH508984. |
| US08884133B2 |
Plants and seeds of hybrid corn variety CH236763
According to the invention, there is provided seed and plants of the hybrid corn variety designated CH236763. The invention thus relates to the plants, seeds and tissue cultures of the variety CH236763, and to methods for producing a corn plant produced by crossing a corn plant of variety CH236763 with itself or with another corn plant, such as a plant of another variety. The invention further relates to genetic complements of plants of variety CH236763. |
| US08884132B2 |
Plants and seeds of hybrid corn variety CH468243
According to the invention, there is provided seed and plants of the hybrid corn variety designated CH468243. The invention thus relates to the plants, seeds and tissue cultures of the variety CH468243, and to methods for producing a corn plant produced by crossing a corn plant of variety CH468243 with itself or with another corn plant, such as a plant of another variety. The invention further relates to genetic complements of plants of variety CH468243. |
| US08884130B2 |
Plants and seeds of hybrid corn variety CH679037
According to the invention, there is provided seed and plants of the hybrid corn variety designated CH679037. The invention thus relates to the plants, seeds and tissue cultures of the variety CH679037, and to methods for producing a corn plant produced by crossing a corn plant of variety CH679037 with itself or with another corn plant, such as a plant of another variety. The invention further relates to genetic complements of plants of variety CH679037. |
| US08884128B1 |
Maize inbred PH1M6A
A novel maize variety designated PH1M6A and seed, plants and plant parts thereof. Methods for producing a maize plant that comprise crossing maize variety PH1M6A with another maize plant. Methods for producing a maize plant containing in its genetic material one or more traits introgressed into PH1M6A through backcross conversion and/or transformation, and to the maize seed, plant and plant part produced thereby. Hybrid maize seed, plant or plant part produced by crossing the variety PH1M6A or a locus conversion of PH1M6A with another maize variety. |
| US08884127B2 |
Plants and seeds of hybrid corn variety CH007473
According to the invention, there is provided seed and plants of the hybrid corn variety designated CH007473. The invention thus relates to the plants, seeds and tissue cultures of the variety CH007473, and to methods for producing a corn plant produced by crossing a corn plant of variety CH007473 with itself or with another corn plant, such as a plant of another variety. The invention further relates to genetic complements of plants of variety CH007473. |
| US08884124B1 |
Soybean cultivar 22164261
A soybean cultivar designated 22164261 is disclosed. The invention relates to the seeds of soybean cultivar 22164261, to the plants of soybean cultivar 22164261, to the plant parts of soybean cultivar 22164261, and to methods for producing progeny of soybean cultivar 22164261. The invention also relates to methods for producing a soybean plant containing in its genetic material one or more transgenes and to the transgenic soybean plants and plant parts produced by those methods. The invention also relates to soybean cultivars or breeding cultivars, and plant parts derived from soybean cultivar 22164261. The invention also relates to methods for producing other soybean cultivars, lines, or plant parts derived from soybean cultivar 22164261, and to the soybean plants, varieties, and their parts derived from use of those methods. The invention further relates to hybrid soybean seeds, plants, and plant parts produced by crossing cultivar 22164261 with another soybean cultivar. |
| US08884123B1 |
Soybean cultivar 14164959
A soybean cultivar designated 14164959 is disclosed. The invention relates to the seeds of soybean cultivar 14164959, to the plants of soybean cultivar 14164959, to the plant parts of soybean cultivar 14164959, and to methods for producing progeny of soybean cultivar 14164959. The invention also relates to methods for producing a soybean plant containing in its genetic material one or more transgenes and to the transgenic soybean plants and plant parts produced by those methods. The invention also relates to soybean cultivars or breeding cultivars, and plant parts derived from soybean cultivar 14164959. The invention also relates to methods for producing other soybean cultivars, lines, or plant parts derived from soybean cultivar 14164959, and to the soybean plants, varieties, and their parts derived from use of those methods. The invention further relates to hybrid soybean seeds, plants, and plant parts produced by crossing cultivar 14164959 with another soybean cultivar. |
| US08884120B2 |
Soybean variety XB32AJ13
A novel soybean variety, designated XB32AJ13 is provided. Also provided are the seeds of soybean variety XB32AJ13, cells from soybean variety XB32AJ13, plants of soybean XB32AJ13, and plant parts of soybean variety XB32AJ13. Methods provided include producing a soybean plant by crossing soybean variety XB32AJ13 with another soybean plant, methods for introgressing a transgenic trait, a mutant trait, and/or a native trait into soybean variety XB32AJ13, methods for producing other soybean varieties or plant parts derived from soybean variety XB32AJ13, and methods of characterizing soybean variety XB32AJ13. Soybean seed, cells, plants, germplasm, breeding lines, varieties, and plant parts produced by these methods and/or derived from soybean variety XB32AJ13 are further provided. |
| US08884118B1 |
Soybean variety XB86G13
A novel soybean variety, designated XB86G13 is provided. Also provided are the seeds of soybean variety XB86G13, cells from soybean variety XB86G13, plants of soybean XB86G13, and plant parts of soybean variety XB86G13. Methods provided include producing a soybean plant by crossing soybean variety XB86G13 with another soybean plant, methods for introgressing a transgenic trait, a mutant trait, and/or a native trait into soybean variety XB86G13, methods for producing other soybean varieties or plant parts derived from soybean variety XB86G13, and methods of characterizing soybean variety XB86G13. Soybean seed, cells, plants, germplasm, breeding lines, varieties, and plant parts produced by these methods and/or derived from soybean variety XB86G13 are further provided. |
| US08884117B1 |
Soybean variety XB77C12
A novel soybean variety, designated XB77C12 is provided. Also provided are the seeds of soybean variety XB77C12, cells from soybean variety XB77C12, plants of soybean XB77C12, and plant parts of soybean variety XB77C12. Methods provided include producing a soybean plant by crossing soybean variety XB77C12 with another soybean plant, methods for introgressing a transgenic trait, a mutant trait, and/or a native trait into soybean variety XB77C12, methods for producing other soybean varieties or plant parts derived from soybean variety XB77C12, and methods of characterizing soybean variety XB77C12. Soybean seed, cells, plants, germplasm, breeding lines, varieties, and plant parts produced by these methods and/or derived from soybean variety XB77C12 are further provided. |
| US08884114B2 |
Soybean variety D2011902
The invention relates to the soybean variety designated D2011902. Provided by the invention are the seeds, plants and derivatives of the soybean variety D2011902. Also provided by the invention are tissue cultures of the soybean variety D2011902 and the plants regenerated therefrom. Still further provided by the invention are methods for producing soybean plants by crossing the soybean variety D2011902 with itself or another soybean variety and plants produced by such methods. |
| US08884112B2 |
Soybean variety A1026631
The invention relates to the soybean variety designated A1026631. Provided by the invention are the seeds, plants and derivatives of the soybean variety A1026631. Also provided by the invention are tissue cultures of the soybean variety A1026631 and the plants regenerated therefrom. Still further provided by the invention are methods for producing soybean plants by crossing the soybean variety A1026631 with itself or another soybean variety and plants produced by such methods. |
| US08884110B2 |
Soybean variety A1026602
The invention relates to the soybean variety designated A1026602. Provided by the invention are the seeds, plants and derivatives of the soybean variety A1026602. Also provided by the invention are tissue cultures of the soybean variety A1026602 and the plants regenerated therefrom. Still further provided by the invention are methods for producing soybean plants by crossing the soybean variety A1026602 with itself or another soybean variety and plants produced by such methods. |
| US08884107B2 |
Soybean variety A1026402
The invention relates to the soybean variety designated A1026402. Provided by the invention are the seeds, plants and derivatives of the soybean variety A1026402. Also provided by the invention are tissue cultures of the soybean variety A1026402 and the plants regenerated therefrom. Still further provided by the invention are methods for producing soybean plants by crossing the soybean variety A1026402 with itself or another soybean variety and plants produced by such methods. |
| US08884105B2 |
Soybean variety A1026393
The invention relates to the soybean variety designated A1026393. Provided by the invention are the seeds, plants and derivatives of the soybean variety A1026393. Also provided by the invention are tissue cultures of the soybean variety A1026393 and the plants regenerated therefrom. Still further provided by the invention are methods for producing soybean plants by crossing the soybean variety A1026393 with itself or another soybean variety and plants produced by such methods. |
| US08884103B1 |
Canola variety 45H31
A novel canola variety designated 45H31 and seed, plants and plant parts thereof, produced by crossing Pioneer Hi-Bred International, Inc. proprietary inbred canola varieties. Methods for producing a canola plant that comprises crossing canola variety 45H31 with another canola plant. Methods for producing a canola plant containing in its genetic material one or more traits introgressed into 45H31 through backcross conversion and/or transformation, and to the canola seed, plant and plant part produced thereby. This invention relates to the canola variety 45H31, the seed, the plant produced from the seed, and variants, mutants, and minor modifications of canola variety 45H31. This invention further relates to methods for producing canola varieties derived from canola variety 45H31. |
| US08884102B2 |
Corn event MIR604
A novel transgenic corn event designated MIR604, is disclosed. The invention relates to DNA sequences of the recombinant constructs inserted into the corn genome and of genomic sequences flanking the insertion site that resulted in the MIR604 event. The invention further relates to assays for detecting the presence of the DNA sequences of MIR604, to corn plants and corn seeds comprising the genotype of MIR604 and to methods for producing a corn plant by crossing a corn plant comprising the MIR604 genotype with itself or another corn variety |
| US08884097B1 |
Method to condition an invertebrate to detect a concentration range of a chemical compound
Described is a method of conditioning an invertebrate to detect a compound at and beyond a threshold range. In one embodiment the conditioned invertebrate is Microplitis croceipes. Compounds the invertebrate can detect include skatole and androstenone. An additional step includes selecting a compound and negatively conditioning the invertebrate at a concentration wherein the invertebrate will not respond to negatively conditioned compound concentration. |
| US08884093B2 |
Method of treating effluents containing halogenated compounds
The present invention relates to the use of catalysts of general formula (I): (L1)M1-X-M2(L2) (I) wherein: M1 and M2, either identical or different, represent metal atoms; X represents a nitrogen atom; L1 and L2, either identical or different are coordinated with M1 and M2, respectively, and represent ligands of the tetradentate type, for catalytic oxidation of halogenated compounds. |
| US08884092B2 |
Simulated moving bed systems for separation of para-xylene and processes for determining pump-around profiles of the simulated moving bed systems
Embodiments of simulated moving bed systems for separating a preferentially adsorbed component from a feed stream and processes for determining a pump-around profile of the simulated moving bed systems are provided. The process comprises the steps of rotating a rotary valve to a first valve position to direct the feed stream to a first adsorbent sub-bed. An intermediate stream between two adsorbent sub-beds in direct fluid communication with each other is irradiated with laser light that is directed from a probe of a Raman system positioned for inline sampling of the intermediate stream. Scattered light from the irradiated intermediate stream is collected with the probe. A spectrum of the scattered light is generated with the Raman system to determine concentrations of the preferentially adsorbed component and one or more other components in the intermediate stream. |
| US08884091B2 |
Integration of hydro-dechlorination and hydro-regeneration
We provide an integrated process to produce alkylate gasoline, comprising: a. alkylating a mixture of hydrocarbons using a chloride-containing ionic liquid catalyst in an alkylation reactor to produce an alkylate gasoline comprising a chloride contaminant; b. hydro-regenerating the chloride-containing ionic liquid catalyst in a hydrogenation reactor; c. hydro-dechlorinating the alkylate gasoline comprising the chloride contaminant in a dechlorination reactor at a dechlorination pressure from 0 to 1000 psig of a hydrogenation pressure used in the hydrogenation reactor, to produce a dechlorinated alkylate gasoline; and d. feeding an off-gas, comprising 70 to 99.9 vol % hydrogen, from the dechlorination reactor to the hydrogenation reactor. We also provide an integrated alkylation process unit for conducting this process. |
| US08884090B2 |
Process for the preparation of an olefin
An olefin is prepared from an alkyl alcohol in a process which comprises the steps: a) converting the alkyl alcohol into a dialkylether over a first catalyst, to yield a hot dialkylether product stream containing alkyl alcohol, dialkylether and water; b) cooling the hot dialkylether product stream at least partly by indirect heat exchange with a cold dialkylether product stream to below the dew point of water at the prevailing conditions to obtain a gas-liquid mixture; c) separating the obtained mixture into a liquid water-containing stream and a vaporous dialkylether-rich stream; d) subjecting at least part of the vaporous dialkylether-rich stream, as the cold dialkylether product stream in step b), to heat exchange with the hot dialkylether product stream, to yield a heated dialkylether-rich feed; and e) converting the heated dialkylether-rich feed to an olefin over a second catalyst. |
| US08884088B2 |
Dehydrogenation process
In a dehydrogenation process a hydrocarbon stream comprising at least one non-aromatic six-membered ring compound and at least one five-membered ring compound is contacted with a first catalyst comprising at least one metal component and at least one support and a second catalyst. The first catalyst is utilized to convert at least a portion of the at least one non-aromatic six-membered ring compound in the hydrocarbon stream to at least one aromatic compound and the second catalyst is utilized to convert at least a portion of the at least one five-membered ring compound in the hydrocarbon stream to at least one paraffin. |
| US08884085B2 |
Catalytic oxychlorination
A process is disclosed for the catalytic oxychlorination of an olefin. In the process a feed containing the olefin, O2 and HCl is contacted with an oxychlorination catalyst. The O2/2HCl ratio in the feed is in the range of from 0.50 to 0.58. Catalyst compositions for use in the oxychlorination reaction, in particular the oxychlorination of ethylene, are also disclosed. The catalyst compositions are in the form of particles suitable for use in fluid bed reactors, in particular baffled fluid bed reactors. Preferred catalyst materials comprise from 5.5 wt % to 14 wt % Cu. They may further comprise an earth alkali metal, such as Mg, and/or a rare earth metal. Preferred compositions contain less than 1 wt % of an alkali metal, which preferably is K. |
| US08884079B2 |
Reducing impurities in hydrogenation processes with multiple reaction zones
In a hydrogenation processes, a second lower temperature hydrogenation reactor is used to control the concentration of impurities, namely ethyl acetate, acetaldehyde, and acetal, prior to separating the reaction mixtures. Controlling impurities reduces the need for separation capital and improves overall efficiencies for recovering alcohols. |
| US08884078B1 |
Process for producing fatty alcohols from fatty acids
In a process for the production of fatty alcohol(s) a fatty acid or fatty acid mixture is subjected to esterification with a lower alkanol to form a stream comprising the corresponding lower alkyl ester or esters. The stream is vaporized and subjected to hydrogenation to form a stream comprising fatty alcohol(s) and an amount of unconverted lower alkyl ester(s). This stream is subjected to transesterification in a wax ester reactor in the presence of a solid transesterification catalyst. Fatty alcohol(s) and wax ester(s) are then separated by distillation to yield a fatty alcohol(s) product and a stream comprising wax ester(s). The stream of wax ester(s) is passed to a second hydrogenation zone to effect hydrogenation in the liquid phase to revert the wax ester(s) to fatty alcohol(s), which are returned to the distillation separation step. |
| US08884076B2 |
Method for preparing polymethylols
The present invention relates to a process for distilling an aqueous polymethylol mixture which comprises a polymethylol of the formula (I) (HOCH2)2—C—R2 (I) in which each R is independently a further methylol group or an alkyl group having 1 to 22 carbon atoms or an aryl or aralkyl group having 6 to 22 carbon atoms, a tertiary amine, water and the adduct of tertiary amine and formic acid (amine formate), which comprises performing the distillation in a distillation column which is connected at the bottom to an evaporator, the bottom temperature being above the evaporation temperature of the monoester of formic acid and polymethylol (polymethylol formate) which forms during distillation. The present invention further relates to a composition comprising polymethylol and 1 to 10 000 ppm by weight of polymethylol formate, and to the use thereof. |
| US08884073B2 |
Processes for preparing polytrimethylene ether glycol
Provided are processes for preparing low molecular weight polytrimethylene ether glycol by acid catalyzed polycondensation, neutralization, removal of unreacted monomer, and contact with filter aid. The processes can avoid hydrolysis and yet provide product substantially free of catalyst derived end groups. |
| US08884068B2 |
Phenol and cyclohexanone mixtures
Disclosed herein is a process for producing phenol. The process includes oxidizing at least a portion of a feed comprising cyclohexylbenzene to produce an oxidation composition comprising cyclohexyl-1-phenyl-1-hydroperoxide. The oxidation composition may then be cleaved in the presence of an acid catalyst to produce a cleavage reaction mixture comprising the acid catalyst, phenol and cyclohexanone. At least a portion of the cleavage reaction mixture may be neutralized with a basic material to form a treated cleavage reaction mixture. In various embodiments, the cleavage reaction mixture contains 1 wt % to 30 wt % phenol, 1 wt % to 30 wt % cyclohexanone and a complexation product. |
| US08884059B2 |
Electrodepositable coating composition containing a cyclic guanidine
The present invention is directed towards an electrocoating composition comprising a cyclic guanidine. |
| US08884058B2 |
Preparation of (R)-N-(3,4-difluoro-2-(2-fluoro-4-iodophenylamino)-6-methoxyphenyl)-1-(2,3-dihydroxypropyl)cyclopropane-1-sulfonamide and (S)-N-(3,4-difluoro-2-(2-fluoro-4-iodophenylamino)-6-methoxyphenyl)-1-(2,3-dihydroxypropyl)cyclopropane-1-sulfonamide
The present invention relates to the preparation of (R)—N-(3,4-difluoro-2-(2-fluoro-4-iodophenylamino)-6-methoxyphenyl)-1-(2,3-dihydroxypropyl)cyclopropane-1-sulfonamide and (S)—N-(3,4-difluoro-2-(2-fluoro-4-iodophenylamino)-6-methoxyphenyl)-1-(2,3-dihydroxypropyl)cyclopropane-1-sulfonamide. |
| US08884057B2 |
Non-crystalline oxidized glutathione and production method therefor
A non-crystalline amorphism of oxidized glutathione is produced by drying a crystal of oxidized glutathione hexahydrate at a temperature of 40 to 90° C. |
| US08884054B2 |
Process for oxidizing alkyl aromatic compounds
A process and a mixture for oxidizing an alkyl-aromatic compound comprises forming a mixture comprising the alkyl-aromatic compound, a solvent, a bromine source, and a catalyst; and contacting the mixture with an oxidizing agent at oxidizing conditions to produce an oxidation product comprising at least one of an aromatic aldehyde, an aromatic alcohol, an aromatic ketone, and an aromatic carboxylic acid. The solvent comprises a carboxylic acid having from 1 to 7 carbon atoms and an ionic liquid selected from the group consisting of an imidazolium ionic liquid, a pyridinium ionic liquid, a phosphonium ionic liquid, a tetra alkyl ammonium ionic liquid, and combinations thereof. The catalyst comprises at least one of cobalt, titanium, manganese, chromium, copper, nickel, vanadium, iron, molybdenum, tin, cerium, and zirconium. |
| US08884053B2 |
Method for the manufacture of aminoalkylene phosphonic acid
A method for the manufacture of amino alkylene phosphonic acids is disclosed. Pure P4O6 is hydrolyzed in the presence of a homogeneous Broensted acid catalyst whereby the pH of the reaction medium is maintained below 5 and the free water content of said reaction medium is, after the P4O6 hydrolysis has been completed, from 0 to 40%. The required amine component can be added before, during, or in one preferred execution, after the P4O6 hydrolysis has been completed. Formaldehyde is then added and the reaction mixture containing the P4O6 hydrolysate, the amine and the formaldehyde is reacted in presence of a Broensted acid catalyst selected from homogeneous and heterogeneous species. The amino alkylene phosphonic acid reaction product can then be recovered in a manner known per sé. |
| US08884051B2 |
Synthesis of methylene malonates using rapid recovery in the presence of a heat transfer agent
The present invention provides a method of making a methylene malonate monomer that includes the steps of reacting a malonic acid ester with a source of formaldehyde optionally in the presence of an acidic or basic catalyst and optionally in the presence of an acidic or non-acidic solvent to form reaction complex. The reaction is optionally performed in the presence of or contacted with an energy transfer means such as a heat transfer agent, a heat transfer surface, a source of radiation or a laser such that reaction complex is substantially vaporized to produce a vapor phase comprising methylene malonate monomer which may be isolated. The present invention further provides methylene malonate monomers prepared by the method of the invention, as well as compositions and products formed from the methylene malonate monomers, including monomer-based products (e.g., inks, adhesives, coatings, sealants or reactive molding) and polymer-based products (e.g., fibers, films, sheets, medical polymers, composite polymers and surfactants). |
| US08884042B2 |
Hydrogenation of fatty acids using a promoted supported nickel catalyst
The invention is directed to a process for the hydrogenation of unsaturated fatty acids to produce saturated fatty acids, said process comprising hydrogenating the unsaturated fatty acid in the presence of hydrogen and a supported nickel catalyst, said supported nickel catalyst comprising an oxidic support, 5 to 80 wt. % of nickel, calculated as atomic nickel on the weight of the catalyst, 0.1 to 10 wt. % of a copper promoter, calculated as atomic copper on the weight of the catalyst and 1 to 10 wt. % of a group II metal, calculated as metallic oxide on the weight of the catalyst. |
| US08884041B2 |
Method for synthesizing an omega-amino acid or ester from a monounsaturated fatty acid or ester
A method for synthesizing ω-amino-alkanoic acids or the esters thereof from natural unsaturated fatty acids passing through an intermediate ω-unsaturated nitrile compound. The method is simple to implement and, relative to known methods, avoids the environmental constraints and economic disadvantages resulting from the reaction by-products. The method includes synthesizing an ω-amino acid (ester) of formula R3OOC—(CH2)q-CH2NH2, in which R3 is H or an n-butyl radical and q is an integral index of between 2 and 13, from a monounsaturated fatty acid (ester) of formula (R1-CH═CH—(CH2)p-COO)xR2, in which x represents 1, 2 or 3, R1 is H or a hydrocarbon radical comprising from 4 to 11 carbon atoms and, where appropriate, a hydroxyl function, R2 is H or an alkyl radical comprising from 2 to 4 carbon atoms, and may contain one or more heteroatoms, and p is an integral index of between 2 and 11, including a reaction step of ammoniation. |
| US08884038B2 |
Synthesis of 7-acetyleno quinone methide derivatives and their application as vinylic polymerization retarders
The invention provides a method for synthesizing 7-Acetyleno quinone methide compounds that is safe and inexpensive. The method avoids the need for extremely cold reaction temperatures and unlike the prior art does not require any highly explosive materials. The method comprises the steps of: a) performing a condensation reaction between 3,5-di-tert-butyl-4-hydroxybenzaldehyde and a secondary amine thereby forming a secondary amine quinone methide intermediate; b) removing water from the secondary amine quinone methide intermediate by azeotropic distillation; c) adding the dehydrated secondary amine quinone methide intermediate to an organic medium containing a metal acetylide to form a Mannich base intermediate; and d) adding a release agent to the Mannich base intermediate to yield a 7-Acetyleno quinone methide. |
| US08884036B2 |
Production of hydroxymethylfurfural from levoglucosenone
Disclosed are processes comprising contacting an aqueous reaction mixture having an initial pH between about 3 and about 6 and comprising levoglucosenone with a catalyst, and heating the reaction mixture to form a product mixture comprising 5-hydroxymethyl-2-furfural. The processes may further comprise heating the product mixture comprising 5-hydroxymethyl-2-furfural in the presence of hydrogen and a hydrogenation catalyst to form a second product mixture comprising one or more of 2,5-furandimethanol, tetrahydrofuran 2,5-dimethanol, 1,2,6-hexanetriol, 2-hydroxymethyltetrahydropyran, and 1,6-hexanediol. |
| US08884030B2 |
Inhibitors of Flaviviridae viruses
Provided are compounds of Formula I: and pharmaceutically acceptable salts and esters thereof. The compounds, compositions, and methods provided are useful for the treatment of Flaviviridae virus infections, particularly hepatitis C infections. |
| US08884026B2 |
Process for preparing rufinamide intermediate
The present invention refers to an improved method for the preparation of compound 1-(2,6-difluorobenzyl)-1H-1,2,3-triazole-4-carboxylic acid substantially free of its 3H-I isomer. The invention also refers to the use of said intermediate for the preparation of Rufinamide and for obtaining a new polymorphic form of Rufinamide, designed as Form R-5. The invention also refers to said new polymorph of Rufinamide, and to the composition containing it and its use as medicament. The new polymorph of Rufinamide shows good stability and appropriate physico-chemical properties for its manipulation on industrial scale. Polymorph Form R-5 will be suitable to use as pharmaceutical for the treatment of convulsions, especially for the treatment of epilepsy. |
| US08884025B2 |
Processes for the preparation of isothiazole derivatives
Processes and intermediates for the preparation of compounds of the Formula (1) and the pharmaceutically acceptable salts, prodrugs, solvates and hydrates thereof, wherein R1, R2, and R3 have the definitions provided herein. |
| US08884023B2 |
Pyrano [3,2-D][1,3]thiazole as glycosidase inhibitors
Novel compounds of formula (I) wherein R1 to R4 and X have the meaning according to the claims, are glucosidase inhibitors, and can be employed, inter alia, for the treatment of Alzheimer's disease. |
| US08884022B2 |
Inhibition of bacterial biofilms with aryl carbamates
Disclosure is provided for carbamate compounds that prevent, remove and/or inhibit the formation of biofilms, compositions including these compounds, devices including these compounds, and methods of using the same. |
| US08884021B2 |
Process for preparing racemic nicotine
Provided is a process for preparing racemic nicotine from 1-methyl-3-nicotinoyl-2-pyrrolidone or a salt thereof using one-pot process. The process comprises the following steps: 1) in a reaction vessel, reacting 1-methyl-3-nicotinoyl-2-pyrrolidone or a salt thereof in the presence of a suitable solvent and a strong acid by heat; after the reaction is complete, cooling the same and adjusting the pH to 7-8 with alkali; and 2) directly adding a reductant into the above vessel, and after the reaction, purifying the product so as to obtain high purity racemic nicotine or a salt thereof. |
| US08884015B2 |
Process for the preparation of a mono-N-alkypiperazine
Process for the preparation of a mono-N-alkylpiperazine of the formula I in which R1 is C1- to C5-alkyl or 2-(2-hydroxyethoxy)ethyl, by reacting diethanolamine (DEOA) of the formula II with a primary amine of the formula H2N—R1 (III) in the presence of hydrogen and a supported, metal-containing catalyst, where the catalytically active mass of the catalyst, prior to its reduction with hydrogen, comprises oxygen-containing compounds of aluminum, copper, nickel and cobalt and, in the range from 0.2 to 5.0% by weight, oxygen-containing compounds of tin, calculated as SnO, and the reaction is carried out in the liquid phase at an absolute pressure in the range from 95 to 145 bar. |
| US08884014B2 |
Method for purifying a fused pyrrolocarbazole derivative
The present invention relates a method for purifying a fused pyrrolocarbazole compound known as 11-isobutyl-2-methyl-8-(2-pyrimidinylamino)-2,5,6,11,12,13-hexahydro-4Hindazolo[5,4-a]pyrrolo[3,4-c]carbazol-4-one using an acid complex thereof. The present invention also relates to a crystalline form of the acid complex. |
| US08884010B2 |
Method for producing pyridazinone compounds and intermediate thereof
The present invention relates to a novel method for producing a pyridazinone compound and an intermediate thereof as shown in the following scheme: wherein the symbols are as defined in the specification. |
| US08884009B2 |
Process for making bortezomib and intermediates for the process
The invention relates to processes of making bortezomib of formula (1) enantiomers thereof and/or intermediates thereof, comprising at least one step of coupling a carboxylic acid with an amine, wherein the coupling step is performed in a presence of the compound of formula (8), wherein A is C1-C6 alkyl group, preferably wherein A is n-propyl group. |
| US08884005B2 |
Method for the preparation of carbapenam compounds
The subject of the present invention is a method of the preparation of compounds containing the core skeleton of carbapenem antibiotics, novel intermediate compounds used in this method, a method of the preparation of the intermediate compounds as well as the use of the intermediate compounds in the production of carbapenem antibiotics. |
| US08883993B2 |
Tetraselmis promoters and terminators for use in eukaryotic cells
The present invention provides novel promoter and terminator sequences for use in gene expression in eukaryotic cells, such as algal cells. The invention further provides expression cassettes comprising a promoter, as described herein, operably linked to a gene. The invention further provides expression vectors and host eukaryotic cells, such as algal cells, for expressing a protein encoded by the gene; and methods for stably transforming eukaryotic algae such as Tetraselmis with transgenes. |
| US08883989B2 |
Fractalkine binding polynucleotides and methods of use
Provided herein are polynucleotides that bind to fractalkine. In one embodiment, a polynucleotide includes the polynucleotide sequence SEQ ID NO:1 or a sequence having at least 80% identity to SEQ ID NO:1. Also provided herein are structures that include such a polynucleotide present on its surface, including 2-dimentional and 3-dimentional structures. Also provided are compositions that include such a polynucleotide, and methods for using the polynucleotides. |
| US08883984B2 |
Human monoclonal antibodies to CTLA-4
In accordance with the present invention, there are provided fully human monoclonal antibodies against human cytotoxic T-lymphocyte antigen 4 (CTLA-4). Nucleotide sequences encoding and amino acid sequences comprising heavy and light chain immunoglobulin molecules, particularly contiguous heavy and light chain sequences spanning the complementarity determining regions (CDRs), specifically from within FR1 and/or CDR1 through CDR3 and/or within FR4, are provided. Further provided are antibodies having similar binding properties and antibodies (or other antagonists) having similar functionality as antibodies disclosed herein. |
| US08883970B2 |
Alpha-amylase variants
The present invention relates to variants (mutants) of polypeptides, in particular Termamyl-like alpha-amylases, which variant has alpha-amylase activity and exhibits an alteration in at least one of the following properties relative to said parent alpha-amylase: substrate specificity, substrate binding, substrate cleavage pattern, thermal stability, pH/activity profile, pH/stability profile, stability towards oxidation, Ca2+ dependency, specific activity, and solubility, in particular under production conditions. |
| US08883969B2 |
Method for production of carotenoid-synthesizing microorganism and method for production of carotenoid
A method for producing a carotenoid comprising the steps of cultivating a cell transformed with a DNA sequence comprising a DNA sequence depicted in anyone of SEQ ID NOs: 2-7 or a cell transformed with a vector having a DNA sequence depicted in anyone of SEQ ID NOs: 2-7 under proper culture conditions and isolating the carotenoid from the cell or the culture. |
| US08883966B2 |
RAB6KIFL/KIF20A epitope peptide and vaccines containing the same
The present invention provides oligopeptides comprising the amino acid sequence selected from the group consisting of SEQ ID NOs: 3, 4 and 5. The present invention also provides a pharmaceutical composition containing the amino acid sequence of selected from the group consisting of SEQ ID NOs: 3, 4 and 5 formulated for the treatment or prevention of cancer in a subject. Furthermore, the present invention provides a method of inducing immune response using such oligopeptides and pharmaceutical agents. |
| US08883962B2 |
Zinc-responsive peptides, and methods of use thereof
Described herein are compounds and methods useful in the detection of, e.g., Zn2+, in vitro and in vivo. The compounds include amino acids and peptides functionalized with a moiety that binds, e.g., Zn2+. The peptides may be further functionalized with a detectable moiety. The peptides may also comprise amino acid sequences known to localize extracellularly or in specific areas within a cell. |
| US08883961B2 |
Process for producing water-absorbing polymer particles
The invention relates to a process for producing water-absorbing polymer particles, comprising thermal postcrosslinking in a contact dryer having external heated outer surfaces. |
| US08883960B2 |
Polyarylene sulfide resin with excellent luminosity and preparation method thereof
The present invention relates to a polyarylene sulfide that is prepared from a composition including 100 parts by weight of solid sulfur, 500 to 10,000 parts by weight of iodinated aryl compounds, and 0.03 to 30 parts by weight of a sulfur-containing polymerization terminator with respect to 100 parts by weight of the solid sulfur, and has a melting temperature (Tm) of 255 to 285° C., and luminosity of 40 or higher as defined by the CIE Lab color model, and a process of preparing the same. The PAS resin is prepared from a composition including a sulfur-containing polymerization terminator and thus has excellent thermal properties and luminosity. |
| US08883956B2 |
Polyimides
Disclosed is a polyimide polymerized by x molar parts of a first diamine, y molar parts of a second diamine, and 100 molar parts of a first dianhydride, wherein the first diamine has a formula of the second diamine has a formula of the first dianhydride has a formula of a+b=100, 50≦x≦80, and 20≦y≦50. |
| US08883954B2 |
Photoactive polymers
A photovoltaic cell is provided that includes a first electrode, a second electrode, and a photoactive layer disposed between the first and second electrodes. The photoactive layer includes a photoactive polymer containing a first monomer repeat unit, which contains a moiety of formula (1): in which A and R are defined in the specification. |
| US08883952B2 |
Optically anisotropic compound and resin composition comprising the same
Disclosed is a silicon containing compound represented by Formula 1 which has high optical anisotropy and high compatibility with a polymer resin. Also, a resin composition including the compound and a polymer resin, and an optical member including the resin composition are disclosed. Since the silicon containing compound represented by Formula 1 has high compatibility with a polymer resin and high optical anisotropy, in the case of an optical member obtained by using a polymer resin composition including the silicon containing compound, there is no phase separation, and it is possible to achieve a required optical characteristic with only a small amount thereof. |
| US08883951B2 |
Composition comprising a monomer for polymerizing branch-type silsesquioxane polymer, branch-type silsesquioxane polymer synthesized from the same and a method for synthesizing the same
A monomer composition for polymerizing a branch-type silsesquioxane polymer is disclosed. The monomer composition includes hydroxy-substituted cyclic siloxane in a solvent, and the hydroxy-substituted cyclic siloxane includes stereoisomers of cyclic siloxane of cis, trans, random and twist structures at controlled ratios. Also disclosed are a branch-type silsesquioxane polymer synthesized by polymerizing the monomer composition for polymerizing a branch-type silsesquioxane polymer, and a method for synthesizing the same. In accordance with the disclosure, the isomers can be isolated stably at desired ratios. The isolated isomers may be polymerized into polymers of various types. Since the polymers exhibit low dielectric property, they may be utilized as low dielectric materials. |
| US08883944B2 |
Method for producing a water-absorbent resin
A method for producing a water-absorbent resin by performing a reversed-phase suspension polymerization of a water-soluble ethylenically unsaturated monomer in a petroleum hydrocarbon dispersion medium, comprising the following steps of: (A) performing a primary dispersion in the absence of surfactants by adding an aqueous solution of a water-soluble ethylenically unsaturated monomer containing a hydrophilic polymeric dispersion agent to a petroleum hydrocarbon dispersion medium in which a hydrophobic polymeric dispersion agent was heat-dispersed or heat-dissolved, under stirring; (B) further performing a secondary dispersion by adding a surfactant to a dispersion liquid obtained after the primary dispersion; and (C) performing the reversed-phase suspension polymerization by using a radical polymerization initiator; and the water-absorbent resin obtained by the method. |
| US08883939B2 |
Method for producing polymers and reactor for carrying out said method
The invention relates to a process for preparing polymers from monomers and/or oligomers by adding a liquid comprising the monomers and/or oligomers dropwise to a continuous liquid phase in a reactor, the continuous liquid phase being immiscible with the liquid comprising the monomers and/or oligomers, and the monomers and/or oligomers reacting in the continuous liquid phase to give the polymer. The liquid comprising the monomers and/or oligomers is shaped to droplets outside the continuous liquid phase, which are subsequently introduced into the continuous liquid phase. The invention further relates to a reactor for performing the process, comprising a tube through which a continuous liquid phase flows, and means of generating droplets, the means of generating droplets being arranged such that the droplets are generated outside the continuous liquid phase and then introduced into the continuous liquid phase. |
| US08883938B2 |
Resin composition for fiber-reinforced composite material, cured product thereof, fiber-reinforced composite material, molding of fiber-reinforced resin, and process for production thereof
The present invention provides a resin composition for a fiber-reinforced composite material, which has excellent fluidity at low temperature and which produces a cured product having excellent mechanical strength, and also provides a cured product thereof, a fiber-reinforced composite material, a fiber-reinforced resin molding having excellent heat resistance, and a process for producing a fiber-reinforced resin molding with good productivity. A resin composition for a fiber-reinforced composite material contains, as essential components, an epoxy resin (A), an acid group-containing radical polymerizable monomer (B), a radical polymerization initiator (C), and an amine-based curing agent (D) for an epoxy resin, and has a viscosity of 500 mPa·s or less at 50° C. measured with an E-type viscometer. The composition is impregnated into reinforcing fibers and cured. |
| US08883934B2 |
Method for making low density polyurethane foam for sound and vibration absorption
Flexible polyurethane foams that function well in noise and vibration absorption applications are made from a mixture of polyether polyols oxides that each has a hydroxyl equivalent weight of from 1200 to 3000 and at least 70% primary hydroxyl groups. From 5 to 80% by weight of the ethylene oxide-capped polypropylene oxides are nominally difunctional, from 0.5 to 20% by weight of the ethylene oxide-capped polypropylene oxides have a nominal functionality of four or higher, and the balance of the ethylene oxide-capped polypropylene oxides, but not less than 1.5% by weight thereof, are nominally trifunctional. |
| US08883932B2 |
Modified alkoxylation products having at least one non-terminal alkoxysilyl group, with increased storage life and increased stretchability of the polymers prepared using them
New alkoxylation products which carry alkoxysilyl groups, mostly in the form of (poly)ether alcohols or copolymers comprising polyether blocks, which are characterized in that the reactivity of the hydroxyl function is reduced, and also to processes for preparing them and to their use. |
| US08883929B2 |
Functionalized vinyl polymer nanoparticles
Nanoparticles of functionalized, cross-linked vinyl polymer, usable as reinforcing filler in a polymeric matrix. The vinyl polymer is a copolymer of at least the following monomers, which are all copolymerizable by free-radical polymerization: a non-aromatic vinyl monomer “A”; a monomer “B” bearing a function Z of formula ≡Si—X, where X represents a hydroxyl or hydrolysable group; and a cross-linking monomer “C” which is at least bifunctional from the point of view of the polymerization. The vinyl polymer is preferably a polymethacrylate, in particular a copolymer of methyl methacrylate (monomer A), trimethoxysilylpropyl methacrylate (monomer B) and ethylene glycol dimethacrylate (monomer C), being in the form of nanobeads the diameter of which is of between 10 and 100 nm. |
| US08883923B2 |
Golf ball
The present invention provides a golf ball comprising a core and a cover covering the core, wherein the cover is formed from a cover composition containing a non-petroleum based polyester resin as a resin component (A) and a needle-like and/or fibrous filler (B). The present invention further provide a golf ball comprising a core and a cover covering the core, wherein the cover is formed from a cover composition containing, a non-petroleum based polyester resin (A-1), at least one petroleum based thermoplastic resin (A-2), and a compatibilizer (C) containing at least a (meth)acrylic resin (C-1) having a polar functional group and an olefin resin (C-2) having a polar functional group.According to the present invention, durability, abrasion resistance and repulsion of a golf ball can be improved. |
| US08883920B2 |
Resin composition and multilayer structural body employing the same
The present invention provides a resin composition which comprises: (A) a saponifed ethylene-vinyl ester copolymer; (B) a rubber-like graft polymer; and (C) a polyalkylene ether unit-containing polymer. The inventive resin composition, which employs the saponfied ethylene-vinyl ester copolymer, is excellent in impact resistance. |
| US08883915B2 |
Hydrophobic and hydrophilic interpenetrating polymer networks derived from hydrophobic polymers and methods of preparing the same
A composition of matter comprising a hydrophobic or hydrophilic (or both) interpenetrating polymer network containing a non-ionic/ionic polymer and a hydrophobic thermoset or thermoplastic polymer, articles made from such composition and methods of preparing such articles. The invention also includes a process for preparing a hydrophobic/hydrophilic IPN or semi-IPN from a hydrophobic thermoset or thermoplastic polymer including the steps of placing an non-ionizable/ionizable monomer solution in contact with a hydrophobic thermoset or thermoplastic polymer; diffusing the monomer solution into the hydrophobic thermoset or thermoplastic polymer; and polymerizing the monomers to form a penetrating polymer inside the hydrophobic thermoset or thermoplastic polymer, thereby forming the IPN or semi-IPN. |
| US08883914B2 |
Article formed from a resin composition having a polyurethane encapsulated particle
A resin composition includes a compound having at least two reactive hydrogen atoms and a polyurethane encapsulated particle including a core particle and a polyurethane layer disposed about the core particle. The resin composition may be used in an article and in a method of making the article. The article includes the reaction product of the resin composition and an isocyanate that are reacted in the presence of the polyurethane encapsulated particle. The method of making the article includes providing the core particle in a vessel. The method also includes introducing and combining a polyol component and an isocyanate component to encapsulate the core particle. The method further includes introducing and combining the resin composition and the isocyanate, in the presence of the polyurethane encapsulated particle, to form the article. |
| US08883906B2 |
Elastomeric nanocomposites, nanocomposite compositions, and methods of manufacture
A nanocomposite is formed from at least one copolymer and at least one nanofiller. The copolymer is formed of units derived from isoolefins having from 4 to 7 carbon atoms and multiolefins. The nanofiller comprising a surfactant wherein the surfactant has the structure of (R1R2R3R4)N+ wherein R1 is benzyl derived unit, which may or may not be substituted, wherein R2 is selected from C1 to C26 alkyls, C2 to C26 alkenes, and C3 to C26 aryls, and wherein R3 and R4 are the same or different and are independently selected from C9 to C26 alkyls, C9 to C26 alkenes, and C9 to C26 aryls. |
| US08883904B2 |
Mixtures of silver and zinc oxide as stabilizer for flame-retardant polyamides
Thermoplastic molding compositions comprisingA) from 10 to 99.8% by weight of a thermoplastic polyamide,B) from 0.1 to 60% by weight of red phosphorus,C) from 0.05 to 20% by weight of a stabilizer mixture C) composed of, based on 100% of C), C1) from 10.1 to 99.9% by weight of elemental Ag and C2) from 0.1 to 89.9% by weight of ZnO, D) from 0 to 40% by weight of an impact modifier, and E) from 0 to 60% by weight of further additives, where the sum of the percentages by weight of A) to E) is 100%. |
| US08883901B2 |
Process for stabilizing hypophosphite salts
The current invention relates to a process for stabilizing a hypophosphite salt, comprising the step of heating the hypophosphite salt at a temperature of between 150 and 370° C. during a sufficient period of time to prevent the formation of a dangerous quantity of phosphine in their application as FR in polymers and a flame retardant polymer composition comprising a polymer and 0.1 to 30 weight percent based on the total weight of the composition of the hypophosphite salt thermally stabilized by the above process. |
| US08883896B2 |
Adhesive composition for an optical film
A non-crosslinking type adhesive composition for an optical film is provided that has excellent adhesion to a substrate, allows peeling to be carried out at a suitable peeling strength without leaving an adhesive residue, has excellent reworking properties, can maintain good adhesion properties for a long time, and has excellent durability. The adhesive composition for an optical film includes an acrylic triblock copolymer, which does not have an NCO functional group, and an isocyanate compound. The acrylic triblock copolymer (I), which is represented by the formula A1-B-A2, is formed by alkyl methacrylate polymer blocks A1 and A2 having a Tg of 100° C. or more and an alkyl acrylate polymer block B having a Tg of −20° C. or less, wherein the content of the block B is 40 to 95 mass %, Mw is 50,000 to 300,000, and the molecular weight distribution is 1.0 to 1.5. Based on the mass of the solids in the adhesive composition, the content of the acrylic triblock copolymer (I) is 60 mass % or more, and the content of the isocyanate compound is 0.0015 mass % or more to less than 0.35 mass % in terms of NCO group content. |
| US08883895B2 |
Compositions containing borane or carborane cage compounds and related applications
Compositions comprising a polymer-containing matrix and a filler comprising a cage compound selected from borane cage compounds, carborane cage compounds, metal complexes thereof, residues thereof, mixtures thereof, and/or agglomerations thereof, where the cage compound is not covalently bound to the matrix polymer. Methods of making and applications for using such compositions are also disclosed. |
| US08883894B2 |
Insulating film and printed wiring board provided with insulating film
The present invention provides an insulating film including: a (A) binder polymer; (B) spherical organic beads; and (C) fine particles containing at least one element selected from the group consisting of phosphorus, aluminum, and magnesium, both the (B) spherical organic bead and the (C) fine particles being dispersed in a predetermined state in the insulating film. |
| US08883893B2 |
Flame retardant flash spun sheets
The present invention relates to a flame retardant plexifilamentary film-fibril strand comprising at least one polyolefin and at least one flame retardant selected from the group consisting of: phosphate esters, phosphonate esters, phosphinate esters, polyphosphazines, nitrogen-containing polyphosphates, hindered amines and mixtures thereof. The present invention also relates to flame retardant sheet made from the flame retardant plexifilamentary film-fibril strands. The sheet can be made into a flame retardant building substrate, garment, banner, light reflector and cover. |
| US08883888B2 |
Diarylamine compounds, aging inhibitor, polymer composition, crosslinked rubber product and molded article of the crosslinked product, and method of producing diarylamine compound
There are provided a novel diarylamine compound represented by the following formula (I), (II) or (III), which has at least one signal attributable to the hydrogen of the N—H moiety at 8.30 ppm to 9.00 ppm when a deuterated dimethyl sulfoxide solution of the diarylamine compound is analyzed by 1H-NMR; and an aging inhibitor, a polymer composition, a crosslinked rubber product and a molded article thereof, and a method of producing a diarylamine compound. In the formulas, A1 to A6 each represent an aromatic group which may have a substituent; A represents an aromatic group or a cyclic aliphatic group, which may both have a substituent; L represents 1 or 2; and n represents 0 or 1. |
| US08883887B2 |
Sulfur-modified asphalt emulsion and binder compositions
A Performance Grade sulfur-extended asphalt binder emulsion is made by combining a viscosifier, an emulsifier, a Performance Grade sulfur-extended asphalt binder, optionally a saponification agent, and a base aqueous solution. During creation of the asphalt emulsion, none of the components or combinations of them exceeds 275° F. The Performance Grade sulfur-extended asphalt binder composition is made by combining free or element sulfur, a linear alkane material, optionally a saturated-backbone polymer modifier, optionally a non-aqueous acid, and a base asphalt. The disclosed Performance Graded sulfur-extended asphalt binder and Performance Graded asphalt sulfur-extended asphalt binder emulsion allow operators using these products directly or in combination with aggregates and other materials to mix and blend the compositions, and apply the compositions in the field, at temperatures less than 300° F. |
| US08883885B2 |
Polyamide resin composition and method for producing polyamide resin composition
Disclosed is a polyamide resin composition comprising 0.01 to 50 parts by mass of cellulose fiber having an average fiber diameter of 10 μm or less in relation to 100 parts by mass of a polyamide resin. Also disclosed is a method for producing the polyamide resin composition, wherein the monomer constituting the polyamide resin is subjected to a polymerization reaction in the presence of the cellulose fiber having an average fiber diameter of 10 μm or less in a water-containing state. |
| US08883882B2 |
Non-aqueous dispersion of polymer particles in reactive diluent
The invention relates to a non-aqueous dispersion of organic polymer particles in a reactive diluent. Said non-aqueous dispersion can be obtained in that at least one monomer is polymerized in the reactive diluent, forming the organic polymer particles, wherein the reactive diluent does not participate in said polymerization due to the orthogonal reactivity thereof relative to the monomers, but comprises a functionality allowing later targeted polymerization. Depending on the organic polymer particles or reactive diluents used, the non-aqueous dispersion can be used in multifaceted applications having a wide range of application profiles. In order to produce said non-aqueous dispersion, polymerization of at least one monomer in a stirred tank reactor in the presence of a reactive diluent is particularly suitable, wherein the conversion is performed at a stirring speed of at least 2 m/s, wherein the ratio of the stirrer diameter to the vessel diameter is set to 0.3-0.80 and the distance from the stirrer to the vessel floor is set to 0.25 to 0.5 times the stirrer diameter. The invention provides multifaceted advantageous applications, particularly as an impact strength modifier, particularly in films, and as an adhesive, as casting resin, or as paint. A particularly advantageous application is producing a molded part or a semi-finished polymer product. |
| US08883880B2 |
Soluble shell polymer composition and method for its preparation
The present invention relates to a soluble shell polymer composition comprising an alkali soluble emulsion polymer shell and an alkali insoluble emulsion polymer core, which composition is stabilized by a surfactant of the formula R—(OCH2CH2)2-6OSO3−M+, where R is a linear, branched, or cyclic C8-C24 alkyl or C12-C18 aralkyl group and M+ is a counterion. The invention further relates to a method of preparing the composition and its use as a binder in coatings formulations. Formulations prepared with the soluble shell polymer composition have excellent freeze-thaw profiles and hiding. |
| US08883878B2 |
Thermoplastic polycarbonate compositions
A thermoplastic composition comprising from 30 to 89.5 wt. % of an aromatic polycarbonate, from 0.5 to 20 wt. % of an impact modifier, from 0 to 25 wt. % of an aromatic vinyl copolymer, from 6 to 35 wt. % of a mineral filler, and from 4 to 20 wt. % of a titanium dioxide, wherein the titanium dioxide is coated with silicone or siloxane, based on the total weight of the composition, has been found to exhibit improved mechanical properties and other characteristics and less degradation than filled thermoplastic compositions without the particular coated titanium dioxide. The composition optionally comprises an acid or acid salt. An article may be formed by molding, extruding, shaping or forming such a composition to form the article. |
| US08883876B2 |
Polymerizable dental material
The subject matter of the invention is a radically polymerizable dental material comprising at least two components. A first component of the dental material contains the salt of a CH-acidic compound, and an additional component contains an acid with acidity greater than that of the CH-acidic compound of the first component. Both components contain radically polymerizable monomers. When the two components are mixed, the acid of the second component converts the salt of the CH-acidic compound of the first component into a CH-acidic molecule, and the CH-acidic molecule triggers the radical polymerization of the monomers. In addition to the advantages of CH-acidic compounds in dental materials on the basis of a reactive resin, the invention achieves long-term storage stability as a result of an increase in the proportion of the reactive resin matrix in polymerizable dental materials. |
| US08883874B2 |
Polymeric compositions comprising at least one volume excluding polymer
The present invention relates to compositions comprising a polymeric substrate comprising at least one volume excluding polymer. In one embodiment, the present invention provides polymeric articles that are capable of acting as osmotic drivers. The articles are capable of maintaining a desired water balance by moving water in or out of a substrate to maintain cation concentration equilibrium between the substrate and its environment. |
| US08883870B2 |
Propylene-alpha-olefin copolymer compositions with improved foaming window
The foaming window for making a foam useful in the manufacture of artificial leather is expanded through the use of a foamable composition comprising (A) a propylene-α-olefin copolymer, (B) a molecular melt (MM) comprising 4,4′-oxydibenzenesulfonylazide (DPO-BSA) and an antioxidant, and (C) a blowing agent. The foaming window can be expanded such that foaming can occur at 220° C. for 20 to 200 or more seconds. |
| US08883866B2 |
Process for production of hydrocarbons with catalyst conditioning
A method for continuous production of hydrocarbons from synthesis gas in the presence of a cobalt-based catalyst which comprises a step of providing synthesis gas from a source (1) of synthesis gas in a Fischer-Tropsch synthesis reactor (4). The method also includes the following steps: a) conditioning of the catalyst in reduced state in a conditioning reactor (2) by contact with a flow of reducing gas from a synthesis gas source supplying the synthesis reactor, the reducing conditioning gas comprising carbon monoxide (CO) or a mixture comprising hydrogen (H2) and carbon monoxide (CO), the H2/CO molar ratio of which is between 0.1 and 0.9, at a temperature between 200 and 500° C., and a total pressure between 0.1 and 5 MPa and under a gas flow between 1 and 20 NI/h/g of catalyst to be treated, b) supply of reduced catalyst conditioned in step a) to the synthesis reactor (4). |
| US08883861B2 |
Iminic monomers and polymers thereof
Disclosed are biocompatible, bioresorbable polymers comprising a plurality of monomeric repeating units containing an imine group, wherein the inclusion of said imine group is effective to lower the melt viscosity, the solution viscosity, or both, compared to the same polymer without an imine group. |
| US08883860B2 |
Method for purifying diatomaceous earth
A method for purifying diatomaceous earth, whose natural colloidal structure is retained, which includes preparing a suspension of diatomaceous earth in a liquid wherein diatomaceous earth is insoluble, separating diatomaceous earth from the suspension, treating diatomaceous earth with an inorganic or organic acid, heat-treating the thus obtained product at a temperature not higher than 300° C., subjecting the product obtained to oxidative treatment and drying the purified product. |
| US08883856B2 |
Compositions and methods for the treatment of inflammatory diseases using topoisomerase inhibitors
Topoisomerase inhibitors are useful for the treatment of inflammatory disorders including arthritis, restenosis, surgical adhesions and other diseases. Controlled release polymeric formulations to topoisomerase inhibitors are particularly suitable for this use. |
| US08883852B2 |
Radioprotective agents
Provided herein are methods, for reducing, preventing, mitigating and treating damage caused by radiation. The methods comprise delivering a compound, as described herein, to a patient in an amount and dosage regimen effective to prevent, mitigate or treat damage caused by radiation or to mitigate apoptosis. The compounds comprise glyburide or other sulfonylurea hypoglycemic compounds or potassium channel inhibitors. |
| US08883846B2 |
Synthesis of bicyclic compounds and method for their use as therapeutic agents
Disclosed embodiments concern the synthesis and use of therapeutic compounds that for treating emerging flu strains and minimizing resistance to such strains. Methods for making the disclosed compounds concern using a base-mediated addition/cyclization sequence followed by functional group manipulation to develop functionalized compounds that can target neuraminidase, which makes them ideal candidates for treating influenza. Pharmaceutical compositions comprising the therapeutic compounds and biologically-acceptable materials are also described. Methods of inhibiting neuraminidase in subjects that are suspected of containing neuraminidase are also described. The use of metabolites of the disclosed compounds can also be used in diagnostic assays for therapeutic dosing of the disclosed compounds. |
| US08883845B2 |
Method for treating bronchial diseases
Administration of a loop diuretic in nebulized dry powder form directly to a patient's lungs for treating bronchial disease. |
| US08883840B2 |
Enantiomers of spiro-oxindole compounds and their uses as therapeutic agents
This invention is directed to the (S)-enantiomer of the compound of formula (I): or a pharmaceutically acceptable solvate or prodrug thereof. This (S)-enantiomer is useful for the treatment of diseases or conditions, such as pain, which are ameliorated or alleviated by the modulation of voltage-gated sodium channels. |
| US08883837B2 |
Morpholinyl containing benzimidazoles as inhibitors of respiratory syncytial virus replication
The present invention concerns morpholinyl containing benzimidazoles having inhibitory activity on the replication of the respiratory syncytial virus and having the formula a prodrug, N-oxide, addition salt, quaternary amine, metal complex or stereochemically isomeric form thereof. It further concerns the preparation thereof and compositions comprising these compounds, as well as the use thereof as a medicine. |
| US08883836B2 |
Solid forms of bendamustine hydrochloride
Novel solid forms of bendamustine hydrochloride are described, as well as methods of their preparation and use. |
| US08883835B2 |
Plant disease controlling composition and method for controlling plant disease
There is provided a plant disease controlling composition comprising at least one compound (A) selected from the group consisting of metconazole, bromuconazole and epoxyconazole, as well as a compound represented by the formula (I): as active ingredients. Also provided is a method for controlling a plant disease, which comprises applying at least one compound (A) selected from the group consisting of metconazole, bromuconazole and epoxyconazole, as well as the compound represented by the formula (I) to a plant, a seed of a plant or a cropland. |
| US08883834B2 |
Methods and compositions for locally increasing body fat
Provided are methods for increasing fat locally in a body of a subject in need thereof comprising percutaneously administering to the subcutaneous fat of the subject a thiazolidinedione or an orexigenic compound, or a pharmaceutically acceptable salt or prodrug thereof, optionally delivered as a composition comprising a pharmaceutically acceptable carrier, as described herein. In certain embodiments, the pharmaceutically acceptable carrier comprises a percutaneous carrier, as described herein. Further provided are compositions comprising a thiazolidinedione or an orexigenic compound, or a pharmaceutically acceptable salt or prodrug thereof, for use according to the invention. |
| US08883833B2 |
Substituted benzoazole PDE4 inhibitors for treating inflammatory, cardiovascular and CNS disorders
The invention relates to substituted benzothiazoles, benzoxazoles—and their counterparts having pyridine and pyrimidine rings replacing the benzene ring—that are PDE4 inhibitors useful for treating stroke, myocardial infarct, and cardiovascular inflammatory conditions, to pharmaceutical compositions comprising these compounds, and to methods for the treatment of stroke, myocardial infarct, and cardiovascular inflammatory conditions in a mammal. The compounds have general formula I: in which A and B are carbocycles or heterocycles. A particular embodiment is |
| US08883830B2 |
Topical therapy for the treatment of migraines, muscle sprains, muscle spasms, spasticity and related conditions
The invention is directed to topical formulations and methods of treating a migraines and/or cluster headaches, muscle sprains, muscle spasms, spasticity, tension headaches, tension related migraines and related conditions associated with muscle tension and pain with a therapeutically effective amount of an ergot alkaloid, skeletal muscle relaxant, serotonin agonist, combinations thereof, pharmaceutically acceptable salt thereof, prodrugs thereof or derivative thereof. |
| US08883829B2 |
2-phenyl-1,2,3-benzotriazoles for UV radiation absorbance
The present invention relates to novel benzotriazoles and to novel topical compositions comprising these benzotriazoles. Furthermore, the invention relates to the use of the novel benzotriazoles as photostabilizer and solubilizer for dibenzoylmethane derivatives such as Butyl Methoxydibenzoylmethane. In one aspect the invention relates to novel benzotriazoles of formula (Ia) wherein R2 is hydrogen; C1-30alkyl; C1-5alkoxy; C1-5alkoxycarbonyl; C5-7cycloalkyl; C6-10aryl or aralkyl; R3 is hydrogen; C1-5alkyl; C1-5alkoxy or halogen, preferably hydrogen or Cl; R4 is hydrogen or C1-5alkyl; R5 is C1-30alkyl or C5-10cycloalkyl. |
| US08883826B2 |
Alkynyl derivatives as modulators of metabotropic glutamate receptors
The present invention relates to novel compounds of formula I wherein W, n, X and W′ are defined in the description; invention compounds are modulators of metabotropic glutamate receptors—subtype 5 (“mGluR5”) which are useful for the treatment of central nervous system disorders as well as other disorders modulated by mGluR5 receptors. |
| US08883825B2 |
Aqueous liquid preparations and light-stabilized aqueous liquid preparations
An aqueous liquid preparation containing (+)-(S)-4-[4-[(4-chlorophenyl)(2-pyridyl)methoxy]piperidino]butyric acid or a pharmacologically acceptable acid addition salt thereof, which is stabilized with a water-soluble metal chloride, is provided. |
| US08883822B2 |
1H-pyrazolo[3,4-B]pyridines and therapeutic uses thereof
Provided herein are compounds according to Formulas (I) or (II) and pharmaceutically acceptable salts thereof, and compositions comprising the same, for use in various methods, including treating cancer, abnormal cellular proliferation, angiogenesis, Alzheimer's disease, lung disease, osteoarthritis, idiopathic pulmonary fibrosis and neurological conditions/disorders/diseases. |
| US08883818B2 |
Hydroxy-6-heteroarylphenanthridines and their use as PDE4 inhibitors
Compounds of the formula Ia***** in which the substituents have the definitions provided in the specification, are novel, effective PDE4 inhibitors, useful in the treatment of atopic eczema. |
| US08883815B2 |
Treatment for cerebral palsy impaired speech in children
Cerebral palsy impaired speech in children and adolescents are effectively treated by administration of a psychostimulant. Low doses of the psychostimulant significantly increases the percentage of correctly pronounced intelligible syllables or words and the ability to more intelligibly communicate. The improvement in speech persists after cessation of or prior to continued psychostimulant treatment. |
| US08883814B2 |
Compositions and methods for enhancing brain function
Compositions and methods are provided that enhance cognition in a human to which the composition is orally administered. Remarkably, clinical studies have proven that contemplated compositions achieve the desired effects using a minimal number of active ingredients at or near threshold active dosages, wherein such compositions almost exclusively comprise huperzine A, vinpocetine or rhodiola, and acetyl-L-carnitine, and optionally further include alpha lipoic acid, rhodiola, and biotin. |
| US08883811B2 |
Synergistic fungicidal mixtures for fungal control in cereals
A fungicidal composition containing a fungicidally effective amount of a compound of Formula I-V and at least one fungicide selected from the group consisting of epoxiconazole, prothioconazole, azoxystrobin, pyraclostrobin, penthiopyrad, isopyrazam, bixafen, boscalid, prochloraz, and chlorothalonil provides synergistic control of selected fungi. |
| US08883810B2 |
Aryl methyl benzoquinazolinone M1 receptor positive allosteric modulators
The present invention is directed to benzoquinazolinone compounds of formula (I) which are M1 receptor positive allosteric modulators and that are useful in the treatment of diseases in which the M1 receptor is involved, such as Alzheimer's disease, schizophrenia, pain or sleep disorders. The invention is also directed to pharmaceutical compositions comprising the compounds, and to the use of the compounds and compositions in the treatment of diseases mediated by the M1 receptor. |
| US08883808B2 |
Combination of 5-HT7 receptor antagonist and serotonin reuptake inhibitor therapy
Patients suffering from serotonin-mediated diseases or conditions, such as depression, may be treated by administering an effective combined amount of a 5-HT7 receptor antagonist and a serotonin reuptake inhibitor. |
| US08883806B2 |
Processes for preparing JAK inhibitors and related intermediate compounds
The present invention is related to processes for preparing chiral substituted pyrazolyl pyrrolo[2,3-d]pyrimidines of Formula III, and related synthetic intermediate compounds. The chiral substituted pyrazolyl pyrrolo[2,3-d]pyrimidines are useful as inhibitors of the Janus Kinase family of protein tyrosine kinases (JAKs) for treatment of inflammatory diseases, myeloproliferative disorders, and other diseases. |
| US08883801B2 |
Substituted pyrazolo[1,5-a]pyrimidines as mTOR inhibitors
The present invention relates to certain pyrazolo[1,5-a]pyrimidine compounds of Formula (I) as inhibitors of mammalian Target Of Rapamycin (mTOR) kinase, which is also known as FRAP, RAFT, RAPT or SEP. The compounds may be used in the treatment of cancer and other disorders where mTOR is deregulated. The present invention further provides pharmaceutical compositions comprising the pyrazolo[1,5-a]pyrimidine compounds. |
| US08883798B2 |
Pyrimidine compounds inhibiting the formation of nitric oxide and prostaglandin E2, method of production thereof and use thereof
The invention provides pyrimidine compounds of general formula (I), which reduce simultaneously the production of nitric oxide (NO) and prostaglandin E2 (PGE2). They have no negative effect on the viability of cells in concentrations decreasing the production of these factors by up to 50%; they are not cytotoxic. Furthermore, a method of preparation of the pyrimidine compounds of general formula (I), carrying 2-formamido group, a pharmaceutical composition comprising the substituted pyrimidine compounds according to the invention, and the use of these compounds for the treatment of inflammatory and cancer diseases are provided. |
| US08883797B2 |
Metalloenzyme inhibitor compounds
The instant invention describes compounds having metalloenzyme modulating activity, and methods of treating diseases, disorders or symptoms thereof mediated by such metalloenzymes. |
| US08883796B2 |
Biphenyl derivatives, pharmaceutical composition comprising the same, and preparation method thereof
Provided are biphenyl derivatives exhibiting activity towards central nervous system diseases by acting on the 5-HT7 receptor, pharmaceutically acceptable salts thereof, a method for preparing the compounds and pharmaceutical compositions including the compounds as an active ingredient. |
| US08883795B2 |
Polymorphic forms of Rifaximin
Provided for in the instant application are two additional polymorphic forms of rifaximin; namely substantially pure APO-I and APO-II. Also provided are processes for preparing substantially pure APO-I and APO-II. Rifaximin is a non-aminoglycoside antibiotic that has previously been found to be useful for the treatment of traveller's diarrhea caused by Escherichia coli bacteria, as well as in the treatment of irritable bowel syndrome, diverticular disease, hepatic encephalopathy, pyogenic skin infections and as an antibacterial prophylactic prior to colon surgery. |
| US08883791B2 |
N-heteroaryl compounds with cyclic bridging unit for the treatment of parasitic diseases
This invention relates to certain N-heteroaryl compounds that are generally useful as medicaments, more specifically as medicaments for animals. The medicament can preferably be used for the treatment of helminth infections and the treatment of parasitosis, such as caused by helminth infections. This invention also relates to uses of the compounds to make medicaments and treatments comprising the administration of the compounds to animals in need of the treatments. This invention also relates to the preparation of the N-heteroaryl compounds. Moreover this invention relates to pharmaceutical compositions and kits comprising the compounds. |
| US08883789B2 |
Piperazine derivatives and their use as positive allosteric modulators of mGluR5 receptors
This invention relates to compounds of formula I their use as positive allosteric modulators of mGlu5 receptor activity, pharmaceutical compositions containing the same, and methods of using the same as agents for treatment and/or prevention of neurological and psychiatric disorders associated with glutamate dysfunction such as schizophrenia or cognitive decline such as dementia or cognitive impairment. R1, R2, R3, R4, Q have meanings given in the description. |
| US08883788B2 |
Fused heterocyclic ring compound
Provided is a compound having a PDE10A inhibitory action, and useful as a medicament for the prophylaxis or treatment of mental diseases such as schizophrenia and the like, and the like. A compound represented by the formula (I): wherein each symbol is as defined in the DESCRIPTION, or a salt thereof. |
| US08883787B2 |
Diazabenzo[de] anthracen-3-one compounds and methods for inhibiting PARP
The present invention relates to diazabenzo[de]anthracen-3-one compounds which inhibit poly(ADP-ribose) polymerase (“PARP”), compositions containing these compounds and methods for using these PARP inhibitors to treat, prevent and/or ameliorate the effects of the conditions described herein. |
| US08883781B2 |
Thienopyrimidines useful as modulators of ion channels
The present invention relates to compounds of formula IA-i useful as inhibitors of ion channels. The invention also provides pharmaceutically acceptable compositions comprising the compounds of the invention and methods of using the compositions in the treatment of various disorders. |
| US08883780B2 |
Crystal of a benzoxazinone compound
Disclosed is a crystal of 2-(hexadecyloxy)-6-methyl-4H-3,1-benzoxazin-4-one useful as a preventive or therapeutic agent for obesity and the like. Specifically disclosed is a crystal of 2-(hexadecyloxy)-6-methyl-4H-3,1-benzoxazin-4-one having a powder X-ray diffraction pattern in which characteristic peaks appear at powder X-ray diffraction interplanar spacings (d) of around 16.54±0.2, 13.26±0.2, 4.70±0.2, 4.38±0.2, and 3.67±0.2λ. |
| US08883778B2 |
Cyclic inhibitors of 11 beta-hydroxysteroid dehydrogenase 1
Disclosed are compounds represented by Formula (I): or pharmaceutically acceptable salts, enantiomers or diastereomers thereof. Also disclosed are pharmaceutical compositions comprising the compounds of Formula (I) or pharmaceutically acceptable salts, enantiomers or diastereomers thereof for the therapeutic treatment of diseases associated with the modulation or inhibition of 11β-HSD1 in mammals. Values for the variables of Formula (I) are defined herein. |
| US08883774B2 |
Methods for increasing the stabilization of hypoxia inducible factor-1 alpha
Disclosed herein are methods for controlling the activity of hypoxia-inducible transcription factor 1-alpha (HIF-1α) and diseases, conditions, or syndromes related thereto, inter alia, Peripheral Vascular Disease (PVD), Coronary Artery Disease (CAD), heart failure, ischemia, and anemia. Further disclosed are pharmaceutical compositions comprising HIF-1α prolyl hydroxylase inhibitors useful in treating diseases, conditions, and/or syndromes related thereto the activity of HIF-1α. |
| US08883772B2 |
Broad spectrum beta-lactamase inhibitors
Broad spectrum beta-lactamase inhibitors. Certain inhibitors also exhibit potent antibiotic activity in addition to beta-lactamase inhibition. Compounds of the invention are designed such that on cleavage of the beta-lactam ring reactive moieties are generated which can inactivate beta-lactamase. Compounds of the invention include those of formula: and pharmacologically acceptable salts thereof where variables Z, Y, M, y, n, R, R4, R5, R1 and R2 are as defined in the specification. M most generally represents a chemical moiety which is in conjugation with the nitrogen of the core beta-lactam ring system of the compound, such that one or more reactive species, e.g., electrophilic or nucleophilic sites are generated on modification of M which is initiated by cleavage of the beta-lactam ring. Also provided are methods of making beta-lactamase inhibitors and beta-lactam antibiotics exhibiting such inhibition. Additionally provided are pharmaceutical compositions containing compounds of the invention for treatment or prevention of bacterial infections and methods of treatment of such infections employing such compounds. |
| US08883771B2 |
Bivalent inhibitors of IAP proteins and therapeutic methods using the same
Inhibitors of IAP proteins and compositions containing the same are disclosed. Methods of using the IAP protein inhibitors in the treatment of diseases and conditions wherein inhibition of IAP proteins provides a benefit, like cancers, also are disclosed. |
| US08883763B2 |
Use of isoquinolones for preparing drugs, novel isoquinolones and method for synthesising same
The use of isoquinolones for preparing drugs, including novel isoquinolones as well as their synthesis method. In particular, isoquinolone derivatives used in the treatment of pathological angiogenesis, and more particularly of cancer. |
| US08883758B2 |
3,5-disubstituted and 3,5,7-trisubstituted-3H-oxazolo and 3H-thiazolo[4,5-d]pyrimidin-2-one compounds and prodrugs thereof
The invention is directed to 3,5-disubstituted and 3,5,7-trisubstituted-3H-oxazolo and 3H-thiazolo[4,5-d]pyrimidin-2-one compounds and prodrugs thereof that have immunomodulatory activity. The invention is also directed to the therapeutic or prophylactic use of such compounds and pharmaceutical compositions containing them, and to methods of treating diseases and disorders described herein, by administering effective amounts of such compounds and prodrugs. |
| US08883757B2 |
Compositions and methods for treatment of ovarian cancer
The disclosure provides compositions and methods for treating an ovarian cancer in a subject. More specifically, the disclosure provides microRNA (miRNA) inhibitor molecules that target to different miRNAs for treating different types of ovarian cancers in a subject. Furthermore, different modifications of miRNA inhibitor molecules as well as different derivatives of miRNA inhibitor molecules are also described. |
| US08883756B2 |
SDF-1 delivery for treating ischemic tissue
Provided herein are methods of treating a cardiomyopathy in a subject by administering directly to, or expressing locally in, a weakened, ischemic, and/or peri-infarct region of myocardial tissue of the subject an amount of SDF-1 effective to cause functional improvement in at least one of the following parameters: left ventricular volume, left ventricular area, left ventricular dimension, cardiac function, 6-minute walk test, or New York Heart Association (NYHA) functional classification. Also provided are methods of treating critical limb ischemia in a subject by administering a DNA plasmid encoding human SDF-1 by direct injection into the affected limb. |
| US08883751B2 |
Composition containing microRNA-21 inhibitor for enhancing radiation sensitivity
Disclosed is a radiation sensitivity-enhancing composition in which a microRNA-21 inhibitor acts as an active ingredient. The microRNA-21 inhibitor is an antisense nucleic acid molecule binding complementarily to microRNA-21. The composition can be administered to a patient in conjunction with irradiation. The inhibitor can act as a radiosensitizer, enhancing the therapeutic effect of such irradiation on cancer high in microRNA-21 expression level, particularly, glioma. |
| US08883750B2 |
Method of treating diabetes
Methods are provided for treating diabetes, lowering plasma level of HbA1c, glucose plasma levels, total cholesterol plasma level, and/or triglyceride plasma level while increasing HDL cholesterol levels and delaying onset of diabetic retinopathy in a diabetic, pre-diabetic, or non-diabetic mammal while minimizing undesirable side effects. |
| US08883749B2 |
Transcription factor inhibitors and related compositions, formulations and methods
The present invention provides small molecules useful to affect cancer cells, along with related methods. The present compounds, formulations, kits and methods are useful for a variety of research, diagnostic and therapeutic purposes. STAT3 inhibitors, particularly LLL12, are disclosed. The STAT3 inhibitors are useful to treat breast cancer in general and breast cancer initiating cells in particular. |
| US08883746B2 |
α-galactosylceramide derivatives, pharmaceutically acceptable salts thereof, preparation method and pharmaceutical composition for the immune adjuvant containing the same as an active ingredient
Disclosed are novel α-galactosylceramide derivatives, pharmaceutically acceptable salts thereof, preparation methods thereof, and pharmaceutical compositions for use in an immune adjuvant containing the same as an active ingredient. The derivatives, in which the amide moiety of α-GalCer is bioisosterically replaced with a triazole moiety, direct cytokine secretion toward IL-4 rather than IFN-γand thus can be used as a therapeutic for autoimmune diseases regulated by IL-4, such as type 1 diabetes and multiple sclerosis. |
| US08883744B2 |
Method and composition for modulating canonical Wnt pathway using folate and inositol
The canonical Wnt signaling pathway is implicated in many disorders including neural tube defects, limb malformations, and heart defects, developmental disorders associated with alcohol exposure (fetal alcohol syndrome) or exposure to bipolar medications (i.e. lithium), wound healing, and Alzheimer's disease. Elevated plasma homocysteine (HCy), which results from folate (folic acid, FA) deficiency, the mood-stabilizing drug lithium (Li), and alcohol (ethanol) are linked to the induction of human congenital heart and neural tube defects. FA supplementation ameliorates the observed developmental errors in the Li-HCy, or alcohol-exposed mouse embryos and normalized heart function. Li, HCy or Wnt3A suppress Wnt-modulated Hex and Islet-1 expression. FA protects from the gene misexpression that is induced by all three factors. Administration of myo-inositol with FA synergistically enhances the protective effect. |
| US08883743B2 |
Methods for treating obesity employing an SGLT2 inhibitor
Methods are provided for treating obesity or causing weight loss in a mammalian subject or patient, wherein a therapeutically effective amount of an SGLT2 inhibitor alone or optionally in combination with another anti-obesity agent, is administered to a mammalian subject or patient. In addition, a pharmaceutical composition is provided which comprises an SGLT2 inhibitor, alone or in combination with another anti-obesity agent, and a pharmaceutically acceptable carrier thereof. |
| US08883742B2 |
Peptide increasing fusiogenic capacity of a gamete
The invention relates to a cyclic peptide increasing the fusiogenic capacity of the oocyte arising from the disintegrin loop of fertilin beta, to a pharmaceutical composition comprising said cyclic peptide and to the use thereof, particularly in order to supplement culture media used to carry out in vitro fertilization. |
| US08883738B2 |
Use of a peptide fragment of CD44v6 in the treatment of ophthalmic diseases
The present invention relates to the use of peptide compounds for the prevention and/or treatment of ophthalmic diseases. In particular, the present invention relates to a peptide compound comprising an amino acid sequence displayed by amino acids 7 to 11 of SEQ ID NO: 2 (KEQWFGNRWHEGYR) or of SEQ ID NO: 1 (KEKWFENEWQGKNP), or a functionally active derivative thereof, or a pharmaceutically acceptable salt thereof, for use in the prevention and/or treatmend of an ophthalmic disease in an individual. While SEQ ID NO: 2 is a part of the human CD44v6, SEQ ID NO: 1 is a part of the rat CD44v6. |
| US08883737B2 |
Methods of treating cancer
Described are methods and compositions for treating epithelial tumors with a folate-vinca conjugate in combination with at least one other chemotherapeutic agent in which the tumors include ovarian, endometrial or non-small cell lung cancer tumors, including platinum-resistant ovarian tumors and platinum-sensitive ovarian tumors. |
| US08883734B2 |
Proteasome-activating anti-aging peptides and compositions containing same
The present invention relates to peptidic compounds of general formula (I): R1—X1-Arg-Lys-Gly-X2—R2. In addition, the present invention relates to, on the one hand, a cosmetic or pharmaceutical composition comprising at least one peptide of general formula (I), in a cosmetically or pharmaceutically acceptable medium and, on the other hand, its utilization to prevent or treat the cutaneous signs of aging and photo-aging and to protect the skin from aggressions due to UV radiation. Lastly, the invention applies to a cosmetic treatment process intended to prevent and/or combat the cutaneous signs of aging and photo aging. |
| US08883730B2 |
Human lung surfactant protein, SP-D, modulates eosinophil activation and survival and enhances phagocytosis of apoptotic bosinophils
The present invention provides the use of formulation with surfactant protein-D (SP-D) in the modulation of activity of human eosinophils derived from hypereosinophilic patients to an increased activation state and increased apoptosis. Accordingly the utility of the invention can be extended in human subjects in resolution of eosinophilic inflammations in related diseases and disorders like neuromuscular and respiratory diseases with eosinophilia other than airway-hyperresponsiveness, allergy and asthma, hypereosinophilic leukemias, hypereosinophilc syndromes (rare hematological diseases), skin diseases like eosinophilia-Myalgia syndrome, eosinophilic fascitis, capillary leak syndromes (IL-2), Churg-Strauss syndrome, toxic oil syndrome, parasitosis, etc., where a large number of stimulated eosinophils accumulate and release a series of growth factors, cytokines, chemokines, bioactive lipid mediators, toxic oxygen metabolites. |
| US08883719B2 |
Bacteriorhodopsin protein variants and methods of use for long term data storage
Bacteriorhodopsin protein variants and methods using the bacteriorhodopsin variants for performance in holographic and three-dimensional (3D) memory storage devices are described. The amino acid and chemical modifications of bacteriorhodopsin provided herein achieve greatly enhanced protein performance. The memory storage devices write, read and erase data proficiently. The bacteriorhodopsin protein variants are useful in optical memory storage and associative processor systems. Irradiation of the light-sensitive protein with light of known wavelength causes the protein to switch between different states. The variants enter the branched photocycle via a single or a two photon process and form the permanent ‘Q’ state more efficiently than the wild-type bacteriorhodopsin protein. This branching photocycle of the variants is exploited in the fabrication of 3D memory storage devices. |
| US08883718B2 |
Treating cancer
Provided is a cyclic peptide which comprises: (i) a CDK4 peptide region; and (ii) a cell-penetrating region; wherein the CDK4 peptide region comprises the amino acid sequence P1R1x1y1R2P2V (SEQ ID NO: 1), in which P1 and P2 are each proline, R1 and R2 are each arginine and each of x1 and y1 are either a linker or proline, wherein if x1 is a linker then y1 is proline or if x1 is proline then y1 is a linker, or wherein x1 and y1 when taken together form a linker, and wherein V may be present or absent; and wherein the cell-penetrating region is capable of enhancing the uptake of the cyclic peptide or a part thereof into cancer cells and comprises an amphiphilic amino acid sequence; and wherein the cyclic peptide or a part thereof is cytotoxic to and/or inhibiting to the growth of a cancer cell. |
| US08883717B2 |
Antigenic compositions and methods
Multilayer films comprised of polypeptide epitopes and a toll-like receptor ligand are described. The multilayer films are capable of eliciting an immune response in a host upon administration to the host. The multilayer films can include at least one designed peptide that includes one or more polypeptide epitopes from a virus, bacteria, fungus or parasite. |
| US08883714B2 |
Pharmaceutical compositions comprising GPR119 agonists which act as peptide YY (PYY) secretagogues
The present invention relates to methods of using GPR119 receptor to identify peptide YY (PYY) secretagogues and compounds useful in the treatment of conditions modulated by PYY, such as conditions modulated by stimulation of NPY Y2 receptor (Y2R). Agonists of GPR119 receptor are useful as therapeutic agents for treating or preventing a condition modulated by PYY, such as a condition modulated by stimulation of Y2R. Conditions modulated by PYY such as may be a condition modulated by stimulation of Y2R include bone-related conditions, metabolic disorders, angiogenesis-related conditions, ischemia-related conditions, convulsive disorders, malabsorptive disorders, cancers, and inflammatory disorders. |
| US08883705B2 |
Cationic micelles with anionic polymeric counterions systems thereof
The invention relates to polymer-micelle complex. The polymer-micelle complexes include a positively charged micelle selected from the group consisting of a monomeric quaternary ammonium compound, a monomeric biguanide compound, and mixtures thereof. The positively charged micelle is electrostatically bound to a water-soluble polymer bearing a negative charge. The polymer does not comprise block copolymer, latex particles, polymer nanoparticles, cross-linked polymers, silicone copolymer, fluorosurfactant, or amphoteric copolymer. The compositions do not form a coacervate, and do not form a film when applied to a surface. |
| US08883702B2 |
Packaged particulate detergent composition
A packaged particulate detergent composition, wherein the composition comprises greater than 40 wt % detergent surfactant, at least 70% by number of the particles comprising a core, comprising mainly surfactant, and around the core, a water soluble coating in an amount of from 10 to 45 wt % based on the coated particle, each coated particle having perpendicular dimensions x, y and z, wherein x is from 0.2 to 2 mm, y is from 2.5 to 8 mm, and z is from 2.5 to 8 mm, the packaged particles being substantially the same shape and size as one another. |
| US08883700B2 |
Dishwashing method utilizing a cationic polymer/surfactant-formed coacervate
The present invention relates to a method of manually cleaning dishware using a liquid hand dishwashing detergent composition comprising an anionic surfactant and a cationic polymer having a MW below or equal to 2,100,000; and a charge density above or equal to 0.45 meq/g, wherein such composition will have a coacervation index upon dilution of at least 2.5%; to provide skin care. |
| US08883698B2 |
Compositions comprising a near terminal-branched compound and methods of making the same
Disclosed herein are novel mixtures of near terminal-branched compounds and derivatives thereof. Further disclosed are methods of making these mixtures, and uses of these mixtures in cleaning compositions (e.g., dishcare, laundry, hard surface cleaners,) and/or personal care compositions (e.g., skin cleansers, shampoo, hair conditioners). |
| US08883697B2 |
Wear resistant lubricious composite
A wear resistant lubricious composite includes a synthetic resin binder, a plurality of transfer film forming particles, and a plurality of hard nanoparticles. The hard nanoparticles are selected from the group consisting of metal oxides, metal carbides and metal nitride nanoparticles. A method of forming wear resistant lubricious composite articles includes the steps of providing a liquid phase synthetic resin precursor, adding a plurality of transfer film forming particles and a plurality of hard nanoparticles selected from the group consisting of metal oxide, metal carbide and metal nitride nanoparticles to the resin precursor to form a mixture, adding a hardener to the mixture, and curing the mixture. |
| US08883691B2 |
Encoded microparticles
Microparticles including spatially coded microparticles, systems for imaging and methods of detecting such microparticles as well as using the same in bioassays are provided. |
| US08883685B2 |
Nitrogen containing isethionic acid salt in registerable, stable agricultural formulations
Embodiments of the present invention disclose an agricultural composition that is a registerable, stable agricultural formulation that includes at least one nitrogen containing isethionic acid salt, at least one plant protection product, at least one surfactant and optionally at least one inert ingredient. |
| US08883683B2 |
Stabilized herbicidal composition
A herbicide composition includes a fenoxaprop ester and a weak acid buffer system. The buffer system maintains the herbicidal composition at a pH in the range of 4 to 8. In one non-limiting embodiment, the fenoxaprop ester is fenoxaprop ethyl. The buffer system can include an amine-containing material, such as a tertiary amine. The herbicide composition can include other herbicides, such as weak acid herbicides, for example pyrasulfotole, bromoxynil, and/or bromoxynil esters and can include one or more safeners. |
| US08883679B2 |
Liquid mycorrhiza compositions
The present invention relates to liquid mycorrhiza compositions and to methods for colonizing a plant, grass, tree or shrub with one or more mycorrhizas. |
| US08883675B2 |
Method for making a highly selective ethylene oxide catalyst
A process for the preparation of a catalyst useful for the vapor phase production of ethylene oxide from ethylene and oxygen comprising providing a catalyst precursor comprising an inert support having a catalytically effective amount of a silver containing compound, a promoting amount of an alkali metal containing compound, and a promoting amount of a transition metal containing compound disposed thereon; calcining the catalyst precursor to convert the silver in the silver containing compound to metallic silver by heating the catalyst precursor to form a catalyst; and curing the catalyst in an inert gas atmosphere at temperatures of about 250° C. to about 600° C. for a period of about 1 hour to 200 hours. |
| US08883674B2 |
Mesoporous electrically conductive metal oxide catalyst supports
A catalyst support material comprising TiO2, and optionally being doped with a transition metal element, and a method for synthesizing the same have been developed. The catalyst support material exhibits an electrical conductivity comparable to widely-used carbon materials. This is because the TiO2 present is primarily arranged in its rutile crystalline phase. Furthermore, a mesoporous morphology provides the catalyst support material with appropriate porosity and surface area properties such that it may be utilized as part of a fuel cell electrode (anode and/or cathode). The TiO2-based catalyst support material may be formed using a template method in which precursor titanium and transition metal alkoxides are hydrolyzed onto the surface of a latex template, dried, and heat treated. |
| US08883673B2 |
Catalyst and process for the manufacture of ultra-low sulfur distillate product
Described is a catalyst and process useful in the hydrodesulfurization of a distillate feedstock to manufacture a low-sulfur distillate product. The catalyst comprises a calcined mixture of inorganic oxide material, a high concentration of a molybdenum component, and a high concentration of a Group VIII metal component. The mixture that is calcined to form the calcined mixture comprises molybdenum trioxide in the form of finely divided particles, a Group VIII metal compound, and an inorganic oxide material. The catalyst is made by mixing the aforementioned starting materials and forming therefrom an agglomerate that is calcined to yield the calcined mixture that may be used as the catalyst or catalyst precursor. |
| US08883672B2 |
Process for preparing modified V-Ti-P catalysts for synthesis of 2,3-unsaturated carboxylic acids
The invention relates to a catalyst composition comprising a mixed oxide of vanadium, titanium, and phosphorus modified with alkali metal. The titanium component is derived from a water-soluble, redox-active organo-titanium compound. The catalyst composition is highly effective at facilitating the vapor-phase condensation of formaldehyde with acetic acid to generate acrylic acid, particularly using an industrially relevant aqueous liquid feed. |
| US08883667B2 |
Purification catalyst for reflow furnace gas, method for preventing contamination of reflow furnace, and reflow furnace
A purification catalyst which prevents contamination within a reflow furnace, including flux components, while suppressing the generation of CO is provided.A purification catalyst for a reflow furnace gas, having one or two of zeolite and silica-alumina as an active ingredient. |
| US08883665B2 |
Alkali-free glass and preparation thereof
The present invention provides the composition of an alkali-free glass composition containing no alkali metal oxide and the preparation thereof. The alkali-free glass comprising substantially no alkali metal oxide according to the present invention comprises 60 to 70 wt % of SiO2; 1 to 3.5 wt % of B2O3; 1 to 13 wt % of Al2O3; 8.5 to 14 wt % of MgO; 1 to 3 wt % of CaO; 4 to 7 wt % of SrO; and 0.5 to 7 wt % of BaO, based on the total weight of oxides present therein. |
| US08883663B2 |
Fusion formed and ion exchanged glass-ceramics
The present disclosure relates to fusion formable highly crystalline glass-ceramic articles whose composition lies within the SiO2—R2O3—Li2O/Na2O—TiO2 system and which contain a silicate crystalline phase comprised of lithium aluminosilicate (β-spodumene and/or β-quartz solid solution) lithium metasilicate and/or lithium disilicate. Additionally, these silicate-crystal containing glass-ceramics can exhibit varying Na2O to Li2O molar ratio extending from the surface to the bulk of the glass article, particularly a decreasing Li2O concentration and an increasing Na2O concentration from surface to bulk. According to a second embodiment, disclosed herein is a method for forming a silicate crystalline phase-containing glass ceramic. |
| US08883661B2 |
Composite material for ballistic protection and relative method of preparation
The present invention regards a composite material for ballistic protection comprising a ballistic fabric substrate having at least one surface provided with a polymer coating obtainable through foaming and subsequent polymerization of a mixture comprising an acrylic resin and a polyurethane resin.The present invention further regards the method for preparing such composite material, as well as a laminated multilayer system, a packet for ballistic protection and an article for ballistic protection comprising such composite material. |
| US08883659B2 |
Airbag and an airbag fabric comprising a polyamide yarn
An object of the present invention is to provide an airbag module ensuring that when an airbag fabricated using a fabric composed of a polyamide yarn excellent in heat resistance is deployed by an inflator gas, the deployment occurs without loss of the gas and an excessive amount of generated gas is not necessary, as a result, the inflator is reduced in weight, and the airbag module of the present invention comprises an airbag fabric composed of a polyamide yarn, wherein the air permeability of the fabric under a pressure of 200 kPa is from 10 to 200 cc/cm2/sec and in the thermal stress of the constituent yarn as measured under the conditions of an initial load of 0.02 cN/dtex, a yarn length of 25 cm and a temperature rise rate of 80° C./min, the summed thermal stress of the total of the warp yarn and the weft yarn at 230° C. is from 0.33 to 1.20 cN/dtex. |
| US08883656B2 |
Single-shot semiconductor processing system and method having various irradiation patterns
High throughput systems and processes for recrystallizing thin film semiconductors that have been deposited at low temperatures on a substrate are provided. A thin film semiconductor workpiece is irradiated with a laser beam to melt and recrystallize target areas of the surface exposed to the laser beam. The laser beam is shaped into one or more beamlets using patterning masks. The mask patterns have suitable dimensions and orientations to pattern the laser beam radiation so that the areas targeted by the beamlets have dimensions and orientations that are conducive to semiconductor recrystallization. The workpiece is mechanically translated along linear paths relative to the laser beam to process the entire surface of the work piece at high speeds. Position sensitive triggering of a laser can be used to generate laser beam pulses to melt and recrystallize semiconductor material at precise locations on the surface of the workpiece while it is translated on a motorized stage. |
| US08883655B2 |
Atomic layer deposition of metal oxide materials for memory applications
Embodiments of the invention generally relate to nonvolatile memory devices, such as a ReRAM cells, and methods for manufacturing such memory devices, which includes optimized, atomic layer deposition (ALD) processes for forming metal oxide film stacks. The metal oxide film stacks contain a metal oxide coupling layer disposed on a metal oxide host layer, each layer having different grain structures/sizes. The interface disposed between the metal oxide layers facilitates oxygen vacancy movement. In many examples, the interface is a misaligned grain interface containing numerous grain boundaries extending parallel to the electrode interfaces, in contrast to the grains in the bulk film extending perpendicular to the electrode interfaces. As a result, oxygen vacancies are trapped and released during switching without significant loss of vacancies. Therefore, the metal oxide film stacks have improved switching performance and reliability during memory cell applications compared to traditional hafnium oxide based stacks of previous memory cells. |
| US08883651B2 |
Semiconductor devices and methods of manufacturing the same
A method of manufacturing a transistor of a semiconductor device, the method including forming a gate pattern on a semiconductor substrate, forming a spacer on a sidewall of the gate pattern, wet etching the semiconductor substrate to form a first recess in the semiconductor substrate, wherein the first recess is adjacent to the spacer, and wet etching the first recess to form a second recess in the semiconductor substrate. |
| US08883646B2 |
Self-assembled monolayer for pattern formation
The present disclosure is directed to a process for the fabrication of a semiconductor device. In some embodiments the semiconductor device comprises a patterned surface. The pattern can be formed from a self-assembled monolayer. The disclosed process provides self-assembled monolayers which can be deposited quickly, thereby increasing production throughput and decreasing cost, as well as providing a pattern having substantially uniform shape. |
| US08883641B2 |
Solution and method for activating the oxidized surface of a semiconductor substrate
The present invention relates to a solution and a method for activating the oxidized surface of a substrate, in particular of a semiconducting substrate, for its subsequent coating by a metal layer deposited by the electroless method.According to the invention, this composition contains: A) an activator consisting of one or more palladium complexes; B) a bifunctional organic binder consisting one or more organosilane complexes; C) a solvent system consisting one or more solvents for solubilizing the said activator and the said binder. |
| US08883639B2 |
Semiconductor device having a nanotube layer and method for forming
A method of forming a semiconductor device includes forming a first conductive layer over the substrate. A dielectric layer, having a first opening, is formed over the first conductive layer. A seed layer is deposited over the first dielectric layer and in the first opening. A layer is formed of conductive nanotubes from the seed layer over the first dielectric layer and over the first opening. A second dielectric is formed over the layer of conductive nanotubes. An opening is formed in the second dielectric layer over the first opening. Conductive material is deposited in the second opening. |
| US08883629B2 |
Adjustable dummy fill
A method of placing a dummy fill layer on a substrate is disclosed (FIG. 2). The method includes identifying a sub-region of the substrate (210). A density of a layer in the sub-region is determined (212). A pattern of the dummy fill layer is selected to produce a predetermined density (216). The selected pattern is placed in the sub-region (208). |
| US08883628B2 |
Electrical connection structure
A structure comprises a top metal connector formed underneath a bond pad. The bond pad is enclosed by a first passivation layer and a second passivation layer. A polymer layer is further formed on the second passivation layer. The dimension of an opening in the first passivation layer is less than the dimension of the top metal connector. The dimension of the top metal connector is less than the dimensions of an opening in the second passivation layer and an opening in the polymer layer. |
| US08883620B1 |
Methods for using isotopically enriched levels of dopant gas compositions in an ion implantation process
A novel process for using enriched and highly enriched dopant gases is provided herein that eliminates the problems currently encountered by end-users from being able to realize the process benefits associated with ion implanting such dopant gases. For a given flow rate within a prescribed range, operating at a reduced total power level of the ion source is designed to reduce the ionization efficiency of the enriched dopant gas compared to that of its corresponding non-enriched or lesser enriched dopant gas. The temperature of the source filament is also reduced, thereby mitigating the adverse effects of fluorine etching and ion source shorting when a fluorine-containing enriched dopant gas is utilized. The reduced levels of total power in combination with a lower ionization efficiency and lower ion source temperature can interact synergistically to improve and extend ion source life, while beneficially maintaining a beam current that does not unacceptably deviate from previously qualified levels. |
| US08883617B2 |
Method for manufacturing a metal oxide semiconductor
One aspect in the present disclosure relates to a method for manufacturing an amorphous metal oxide semiconductor. In an exemplary embodiment, a film is deposited on a substrate from a mixed solution as a starting element. For example, the mixed solution includes at least an indium alkoxide and a zinc alkoxide in a solvent. The film made from the mixed solution on the substrate is cured by thermal-annealing in a water vapor atmosphere, at a temperature range of, for example, 210 to 275 degrees Celsius, inclusive. |
| US08883615B1 |
Approaches for cleaning a wafer during hybrid laser scribing and plasma etching wafer dicing processes
Approaches for cleaning a wafer during hybrid laser scribing and plasma etching wafer dicing processes are described. In an example, a method of dicing a semiconductor wafer having a front surface having a plurality of integrated circuits thereon involves forming an underfill material layer between and covering metal pillar/solder bump pairs of the integrated circuits. The method also involves forming a mask layer on the underfill material layer. The method also involves laser scribing mask layer and the underfill material layer to provide scribe lines exposing portions of the semiconductor wafer between the integrated circuits. The method also involves removing the mask layer. The method also involves, subsequent to removing the mask layer, plasma etching the semiconductor wafer through the scribe lines to singulate the integrated circuits, wherein the second insulating layer protects the integrated circuits during at least a portion of the plasma etching. The method also involves, subsequent to the plasma etching, thinning but not removing the underfill material layer to partially expose the metal pillar/solder bump pairs of the integrated circuits. |
| US08883612B2 |
Method for manufacturing a semiconductor device
A method of manufacturing a semiconductor device includes forming a porous area of a semiconductor body. The semiconductor body includes a porous structure in the porous area. A semiconductor layer is formed on the porous area. Semiconductor regions are formed in the semiconductor layer. Then, the semiconductor layer is separated from the semiconductor body along the porous area, including introducing hydrogen into the porous area by a thermal treatment. |
| US08883611B2 |
Methods of fabricating semiconductor devices having air gaps in dielectric layers
Semiconductor devices, and methods of fabricating the same, include forming a trench between a plurality of patterns on a substrate to be adjacent to each other, forming a first sacrificial layer in the trench, forming a first porous insulation layer having a plurality of pores on the plurality of patterns and on the first sacrificial layer, and removing the first sacrificial layer through the plurality of pores of the first porous insulation layer to form a first air gap between the plurality of patterns and under the first porous insulation layer. |
| US08883607B2 |
Full wafer processing by multiple passes through a combinatorial reactor
Overlapping combinatorial processing can offer more processed regions, better particle performance and simpler process equipment. In overlapping combinatorial processing, one or more regions are processed in series with some degrees of overlapping between regions. In some embodiments, overlapping combinatorial processing can be used in conjunction with non-overlapping combinatorial processing and non-combinatorial processing to develop and investigate materials and processes for device processing and manufacturing. |
| US08883606B2 |
Multi-level thin film capacitor on a ceramic substrate and method of manufacturing the same
In accordance with the teachings described herein, a multi-level thin film capacitor on a ceramic substrate and method of manufacturing the same are provided. The multi-level thin film capacitor (MLC) may include at least one high permittivity dielectric layer between at least two electrode layers, the electrode layers being formed from a conductive thin film material. A buffer layer may be included between the ceramic substrate and the thin film MLC. The buffer layer may have a smooth surface with a surface roughness (Ra) less than or equal to 0.08 micrometers (um). |
| US08883604B2 |
Integrated circuitry comprising nonvolatile memory cells and methods of forming a nonvolatile memory cell
An integrated circuit has a nonvolatile memory cell that includes a first electrode, a second electrode, and an ion conductive material there-between. At least one of the first and second electrodes has an electrochemically active surface received directly against the ion conductive material. The second electrode is elevationally outward of the first electrode. The first electrode extends laterally in a first direction and the ion conductive material extends in a second direction different from and intersecting the first direction. The first electrode is received directly against the ion conductive material only where the first and second directions intersect. Other embodiments, including method embodiments, are disclosed. |
| US08883600B1 |
Transistor having reduced junction leakage and methods of forming thereof
A transistor and method of fabrication thereof includes a screening layer formed at least in part in the semiconductor substrate beneath a channel layer and a gate stack, the gate stack including spacer structures on either side of the gate stack. The transistor includes a shallow lightly doped drain region in the channel layer and a deeply lightly doped drain region at the depth relative to the bottom of the screening layer for reducing junction leakage current. A compensation layer may also be included to prevent loss of back gate control. |
| US08883594B2 |
Vertical tunneling field-effect transistor cell and fabricating the same
A method of making a tunneling field-effect transistor (TFET) device is disclosed. A frustoconical protrusion structure is disposed over the substrate and protrudes out of the plane of substrate. Isolation features are formed on the substrate. A drain region is disposed over the substrate adjacent to the frustoconical protrusion structure and extends to a bottom portion of the frustoconical protrusion structure as a raised drain region. A source region is formed as a top portion of the frustoconical protrusion structure. A series connection and a parallel connection are made among TFET devices units. |
| US08883579B2 |
Array substrate for organic electroluminescent display device and method of fabricating the same
A method of fabricating an array substrate for an organic electroluminescent display device includes forming a semiconductor layer, a semiconductor dummy pattern, a first storage electrode and a first gate insulating layer on a substrate; forming a second gate insulating layer on the semiconductor layer and the first storage electrode; forming a gate electrode and a second storage electrode on the second gate insulating layer; forming ohmic contact layers by doping impurities into both sides of the semiconductor layer; forming an inter insulating layer on the gate electrode and the second storage electrode; forming source and drain electrodes and a third storage electrode on the inter insulating layer; forming a passivation layer on the source and drain electrodes and the third storage electrode; forming a first electrode and a fourth storage electrode on the passivation layer; and forming a spacer and a bank on the first electrode. |
| US08883577B2 |
Semiconductor device and producing method thereof
A semiconductor device manufacturing method includes forming a fin region over a substrate, forming a dummy gate electrode over the fin region, forming a first insulating film over the dummy gate electrode and the fin region, polishing the first insulating film until the dummy gate electrode is exposed, removing part of the exposed dummy gate electrode to form a trench, forming a gate insulator over the surface of the fin region exposed in the trench, and forming a gate electrode over the gate insulator. |
| US08883574B2 |
Transistor with etching stop layer and manufacturing method thereof
This invention provides a transistor with an etching stop layer and a manufacturing method thereof. The transistor structure includes a substrate, a crystalline semiconductor layer, an etching stop structure, an ohmic contact layer, a source, a drain, a gate insulating layer, and a gate. The manufacturing method is performed by patterning the ohmic contact layer and the crystalline semiconductor layer at the same time with the same mask; and patterning the ohmic contact layer and the source/drain layer at the same time with another the same mask. |
| US08883571B2 |
Transistor, method of manufacturing the transistor, semiconductor unit, method of manufacturing the semiconductor unit, display, and electronic apparatus
A method of manufacturing a transistor includes: forming an oxide semiconductor film and a gate electrode on a substrate, the oxide semiconductor film having a channel region, and the gate electrode facing the channel region; and forming an insulating film covering the gate electrode and the oxide semiconductor film. Infiltration of moisture from the insulating film into the oxide semiconductor film is suppressed by the substrate. |
| US08883566B2 |
Method of manufacturing semiconductor device, semiconductor device and multilayer wafer structure
Grooves are formed on the front surfaces of first and second semiconductor wafers each including an aggregate of a plurality of semiconductor chips. The grooves each extend on a dicing line set between the semiconductor chips and to have a larger width than the dicing line. Thereafter the first and second semiconductor wafers are arranged so that the front surfaces thereof are opposed to each other, and the space between the first semiconductor wafer and the second semiconductor wafer is sealed with underfill. Thereafter the rear surfaces of the first and second semiconductor wafers are polished until at least the grooves are exposed, and a structure including the first and second semiconductor wafers and the underfill is cut on the dicing line. |
| US08883564B2 |
Substrate comprising aluminum/graphite composite, heat dissipation part comprising same, and LED luminescent member
A process for producing a substrate, which comprises processing an aluminum/graphite composite into plates having a thickness of 0.5-3 mm using a multi-wire saw under the following conditions (1) to (4): (1) the wires have abrasive grains bonded thereto which are one or more substances selected from diamond, C—BN, silicon carbide, and alumina and have an average particle diameter of 10-100 μm; (2) the wires have a diameter of 0.1-0.3 mm; (3) the wires are run at a rate of 100-700 m/min; and (4) the composite is cut at a rate of 0.1-2 mm/min. The aluminum/graphite composite has a surface roughness (Ra) of 0.1-3 μm, a thermal conductivity at 25° C. of 150-300 W/mK, a ratio of the maximum to the minimum value of thermal conductivity in three perpendicular directions of 1-1.3, a coefficient of thermal expansion at 25-150° C. of 4×106 to 7.5×10−6/K, a ratio of the maximum to the minimum value of coefficient of thermal expansion in three perpendicular directions of 1-1.3, and a three-point bending strength of 50-150 MPa. |
| US08883563B1 |
Fabrication of microelectronic assemblies having stack terminals coupled by connectors extending through encapsulation
A microelectronic assembly or package can include first and second support elements and a microelectronic element between inwardly facing surfaces of the support elements. First connectors and second connectors such as solder balls, metal posts, stud bumps, or the like face inwardly from the respective support elements and are aligned with and electrically coupled with one another in columns. The first connectors, the second connectors or both may be partially encapsulated prior to electrically coupling respective pairs of first and second connectors in columns. A method may include arranging extremities of first connectors or second connectors in a temporary layer before forming the partial encapsulation. |
| US08883555B2 |
Electronic device, manufacturing method of electronic device, and sputtering target
A film formation is performed using a target in which a material which is volatilized more easily than gallium when heated at 400° C. to 700° C., such as zinc, is added to gallium oxide by a sputtering method with high mass-productivity which can be applied to a large-area substrate, such as a DC sputtering method or a pulsed DC sputtering method. This film is heated at 400° C. to 700° C., whereby the added material is segregated in the vicinity of a surface of the film. Another portion of the film has a decreased concentration of the added material and a sufficiently high insulating property; therefore, it can be used for a gate insulator of a semiconductor device, or the like. |
| US08883550B2 |
Deposition processes for photovoltaic devices
Processes for making a solar cell by depositing various layers of components on a substrate and converting the components into a thin film photovoltaic absorber material. Processes of this disclosure can be used to control the stoichiometry of metal atoms in making a solar cell for targeting a particular concentration and providing a gradient of metal atom concentration. A selenium layer can be used in annealing a thin film photovoltaic absorber material. |
| US08883546B2 |
Process for preparing an organic electronic device
The present invention relates to a process for preparing improved electronic devices, in particular organic field effect transistors (OFETs), with patterned insulator and organic semiconductor layers. |
| US08883540B2 |
Method for manufacturing photovoltaic module formed on corrugated-sheet building material
A method for manufacturing a photovoltaic module formed on a corrugated-sheet building material includes: shaping a base board in a manner that the base board thus shaped takes on a corrugated-sheet shape and therefore not only has thereon alternating grooves and ridges but also a processing surface defined between a said groove and an adjacent said ridge; forming a photovoltaic module on the processing surface of the base board by stacking a bottom adhesive film layer, a photovoltaic layer, a top adhesive film layer, and a condensing film layer on the processing surface in bottom-to-top order; rolling the photovoltaic module and the base board against each other at 130˜180° C. to effectuate engagement therebetween; and performing lamination within hermetically sealed space at 140˜170° C. and 2˜10 kg/cm2 for 5˜10 minutes. A back plate layer is disposed beneath the bottom adhesive film layer and connected to the base board through another adhesive film layer. |
| US08883538B2 |
High power density photo-electronic and photo-voltaic materials and methods of making
A high power density photo-electronic and photo-voltaic material comprising a bio-inorganic nanophotoelectronic material with a photosynthetic reaction center protein encapsulated inside a multi-wall carbon nanotube or nanotube array. The array can be on an electrode. The photosynthetic reaction center protein can be immobilized on the electrode surface and the protein molecules can have the same orientation. A method of making a high power density photo-electronic and photo-voltaic material comprising the steps of immobilizing a bio-inorganic nanophotoelectronic material with a photosynthetic reaction center protein inside a carbon nanotube, wherein the immobilizing is by passive diffusion, wherein the immobilizing can include using an organic linker. |
| US08883536B2 |
Systems and methods for a pressure sensor having a two layer die structure
Systems and methods for a pressure sensor are provided, where the pressure sensor comprises a housing having a high side input port that allows a high pressure media to enter a high side of the housing and a low side input port that allows a low pressure media to enter a low side of the housing when the housing is placed in an environment containing the high and low pressure media; a substrate mounted within the housing; a stress isolation member mounted to the substrate; a die stack having sensing circuitry bonded to the stress isolation member; a low side atomic layer deposition (ALD) applied to surfaces, of the substrate, the stress isolation member, and the die stack, exposed to the low side input port; and a high side ALD applied to surfaces, of the stress isolation member and the die stack, exposed to the high side input port. |
| US08883533B2 |
Method for manufacturing light emitting diode package
A method for manufacturing an LED package comprising steps of: providing a substrate and forming spaced electrode structures on the substrate; providing a mold on the top surface of the substrate wherein the mold defines spaced annular grooves which cooperate with the top surface of the substrate to define cavities; filling the cavities with metal material; removing the mold and hardening the metal material to form reflection cups wherein each reflection cup surrounds a corresponding electrode structure and defines a recess; polishing surfaces of the reflection cups and the electrode structures; arranging LED chips in the recesses with each LED chip electrically connected to the electrode structure; injecting an encapsulation layer in the recesses to seal the LED chips; and cutting the substrate to obtain individual LED packages. |
| US08883525B2 |
White light emitting diode (LED) lighting device driven by pulse current
A white LED lighting device driven by a pulse current is provided, which consists of blue, violet or ultraviolet LED chips, blue afterglow luminescence materials A and yellow luminescence materials B. Wherein the weight ratio of the blue afterglow luminescence materials A to the yellow luminescence materials B is 10-70 wt %:30-90 wt %. The white LED lighting device drives the LED chips with a pulse current having a frequency of not less than 50 Hz. Because of using the afterglow luminescence materials, the light can be sustained when an excitation light source disappears, thereby eliminating the influence of LED light output fluctuation caused by current variation on the illumination. At the same time, the pulse current can keep the LED chips being at an intermittent work state, so as to overcome the problem of chip heating. |
| US08883524B2 |
Methods and apparatus for CMOS sensors
Methods and apparatus for a sensor are disclosed. An oxide layer is formed on a substrate, followed by a spacer layer and a buffer layer. A photoresist layer is formed on the buffer layer over a pixel region, with an opening exposing a first part of the buffer layer. A first etching is performed to remove the first part of the buffer layer to expose a first part of the spacer layer. A second etching is performed to remove the first part of the spacer layer, the remaining buffer layer, and partially remove a second part of the spacer layer so that the result spacer layer will have an end with a shape substantially similar to a triangle, a height of the end is in a substantially same range as a length of the end. |
| US08883522B2 |
System for semiconductor device characterization using reflectivity measurement
A system includes a computer-readable medium that stores a plurality of instructions for execution by at least one computer processor. The instructions include receiving a reflectivity measurement on a semiconductor wafer and generating a reflectivity map based on the received reflectivity measurement. The instructions determine a spatial distance for a selected reflectivity change using the generated reflectivity map. Subsequently, the determined spatial distance is compared with a thermal diffusion length of a first anneal process technique. In embodiments, the system further includes a light source and a reflectivity measurement tool. |
| US08883520B2 |
Redeposition control in MRAM fabrication process
Methods and structures are described to reduce metallic redeposition material in the memory cells, such as MTJ cells, during pillar etching. One embodiment forms metal studs on top of the landing pads in a dielectric layer that otherwise covers the exposed metal surfaces on the wafer. Another embodiment patterns the MTJ and bottom electrode separately. The bottom electrode mask then covers metal under the bottom electrode. Another embodiment divides the pillar etching process into two phases. The first phase etches down to the lower magnetic layer, then the sidewalls of the barrier layer are covered with a dielectric material which is then vertically etched. The second phase of the etching then patterns the remaining layers. Another embodiment uses a hard mask above the top electrode to etch the MTJ pillar until near the end point of the bottom electrode, deposits a dielectric, then vertically etches the remaining bottom electrode. |
| US08883519B1 |
Oxidase activity of polymeric coated cerium oxide nanoparticles
Methods, systems, compositions include biocompatible polymer coated nanoceria that function as aqueous redox catalyst with enhanced activity at an acidic to moderately alkaline pH value between 1 and 8. The compositions are used as oxidizing agents for decomposition, decontamination or inactivation of organic contaminants, such as, pesticides and chemical warfare agents. Another use includes nanoceria as targetable nanocatalyst prepared by conjugating various targeting ligands to the nanoparticle coating to form a colorimetric or fluorescent probe in immunoassays and other molecule binding assays that involve the use of a molecule in solution that changes the color of the solution or emits a fluorescent signal, where localization of nanoceria to organs or tissue is assessed by treatment with an oxidation sensitive dye or other detection devices. Versatility and uses of the nanoceria compositions are controlled by pH value, choice of dye substrate and thickness of the polymer coating on the ceria nanoparticles. |
| US08883517B2 |
Detection of antibodies
The present invention relates to a method of detecting a target antibody, particularly a target autoantibody, in a sample, using a small molecule fluorophore-labelled target antigen, or a functional fragment, functional variant or functional derivative thereof that specifically binds to the target antibody. Detection is typically carried out using immunodiffusion or immunoelectrophoresis. The invention also relates to methods of diagnosing disease, particularly autoimmune disease, using small molecule fluorophore labelled target antigens and autoantigens. Small molecule fluorophore labelled target antigens, including autoantigens, are also disclosed, as are uses such. |
| US08883516B2 |
Click chemistry on heterogeneous catalysts
The present invention relates to new methods and reagents for coupling molecules by a Click reaction using a heterogeneous catalyst system. Further, the present invention refers to novel devices for carrying out Click reactions. |
| US08883511B2 |
Method for evaluating chemical stability of polychloroprene latex
Provided is a method for evaluating of the chemical stability of a polychloroprene latex that permits evaluation of the chemical stability of polychloroprene at high accuracy.First, an aqueous calcium hydroxide or calcium nitrate solution at a concentration of 0.05 to 0.40 mass % is added to a polychloroprene latex having a solid matter concentration of 45 to 65 mass %. The generated precipitate is then collected by filtration and the dry mass is determined, and the precipitation rate (%) is calculated according to the following Formula (I). Precipitation rate ( % ) = A { B × ( C / 100 ) } × 100 ( I ) (wherein, A represents the dry mass (g) of the precipitate; B represents the mass (g) of the polychloroprene latex, and C represents the solid matter concentration (mass %) of the polychloroprene latex.) |
| US08883507B2 |
Conditionally immortalized long-term hematopoietic stem cells and methods of making and using such cells
Disclosed are methods for conditionally immortalizing stem cells, including adult and embryonic stem cells, the cells produced by such methods, therapeutic and laboratory or research methods of using such cells, and methods to identify compounds related to cell differentiation and development or to treat diseases, using such cells. A mouse model of acute myeloid leukemia (AML) and cells and methods related to such mouse model are also described. |
| US08883505B2 |
Genetic material manipulation techniques and products thereof
The presently claimed invention applies to a genetic material processing and manipulation method and related product. The claimed invention relates to a method for changing the inherited characteristics of a cell through micro-beam chromosome modification. In one preferred embodiment, improvements to ‘genomic surgery’ are applied to modify source cell genetic material (101). Source cell (106) is stabilized through micro-pipette (102) applied negative pressure. Excised genetic material (101) undergoes a pre-cutting manipulation step (205) to enhance subsequent genetic manipulation. In an additional embodiment genetic material manipulation is aided by a spindle cutting step (303). The presently claimed invention provides a high quality alternate approach to directed genetic recombination without requiring the use of restriction enzymes and is used for chromosomal repair, removal of defects and new organism creation. |
| US08883504B2 |
Cell differentiation suppressing agent, method of culturing cells using the same, culture solution, and cultured cell line
The object of the present invention is to provide a differentiation inhibiting agent which allows culture of a stem cell or an embryonic stem cell in an undifferentiated state without use of any feeder cell, a method for culturing using the same, a cell culture liquid using the same, and a cell prepared by culturing using this differentiation inhibiting agent. The present invention provides a differentiation inhibiting agent which comprises a low molecular weight compound, especially a tetrahydroisoquinoline derivative, as an active ingredient; a method for safely culturing a stem cell in large scale in undifferentiated state in the absence of feeder cell which comprises culturing a stem cell by using a tetrahydroisoquinoline derivative; a culture liquid for stem cells comprising a tetrahydroisoquinoline derivative; and a cell which is obtained by culture using a tetrahydroisoquinoline derivative as a differentiation inhibiting agent. |
| US08883503B2 |
Hydrogel scaffolds for tissue engineering
Disclosed herein are biodegradable hydrogel scaffolds for use in tissue engineering. The hydrogel scaffolds are composed of synthetic terpolymers complexed with polyvinyl alcohol (PVA), which facilitate cell-sheet and tissue growth. In the presence of a monosaccharide, the PVA-hydrogel is dissolved and cell-sheets are released for harvesting. Further disclosed herein are methods for producing PVA hydrogels which support tissue growth. Tissue engineering applications and methods are also disclosed. |
| US08883502B2 |
Expandable cell source of neuronal stem cell populations and methods for obtaining and using them
The invention provides methods for obtaining neural stem cells from a mammalian embryonic or inducible pluripotent stem cell population comprising culturing mammalian embryonic or inducible pluripotent stem cells in a cell culture medium having a leukemia inhibitory factor (LIF), an inhibitor of glycogen synthase kinase 3 (GSK3), and an inhibitor of transforming growth factor β (TGF-β) under suitable conditions and obtaining isolated neural stem cells therefrom. |
| US08883501B2 |
Method for retarding the differentiation of pluripotent cells
There is provided a method of retarding differentiation of a biological cell, the method comprising culturing the cell in the presence of an inhibitor of E-cadherin activity. The method is particularly advantageous in retarding the differentiation of stem or progenitor cells, and allows suspension culture of such cells in a manner that enables large scale expansion of cell populations. There is also provided a stem or progenitor cell comprising a construct encoding an inhibitor of E-cadherin activity; and a cell culture medium, for use in the retardation of biological cell differentiation, comprising an inhibitor of E-cadherin activity. |
| US08883500B2 |
Method of preparing adenosine-resistant anti-tumor T lymphocytes for adoptive immunotherapy
In the past, adoptive immunotherapy often failed because the transferred immune cells were inactive in vivo. This disclosure provides a method of producing immune cells that are highly active in vivo. The immune cells may be expanded in vitro in the presence of an adenosine receptor agonist or an antisense nucleic acid that downregulates expression of an adenosine receptor, for example. The immune cells may be tumor-infiltrating lymphocytes (TIL), cytotoxic T lymphocytes (CTL), natural killer (NK) cells, or lymphokine-activated killer (LAK) cells, for example. The methods described herein may be used to treat a number of diseases including cancer, infectious diseases, and immunodeficiencies. |
| US08883499B2 |
Systems and methods for isolating and using clinically safe adipose derived regenerative cells
Systems and methods are described that are used to separate cells from a wide variety of tissues. In particular, automated systems and methods are described that separate regenerative cells, e.g., stem and/or progenitor cells, from adipose tissue. The systems and methods described herein provide rapid and reliable methods of separating and concentrating regenerative cells suitable for re-infusion into a subject. |
| US08883494B2 |
In vitro model for neuronal death
This invention demonstrates the formation of a novel polarized membrane lipid raft signaling module in neurons, in response to several diverse neurotoxic stimuli. This polarization occurs well before neurons commit to die, and is an early mechanism in death signaling. The formation of this signaling module is dependent on cholesterol for its formation and provides a mechanistic explanation for the protective effects of cholesterol depleting drugs in several non-neural models of cell death. As such, the formation of the signaling module lends itself as a novel screen for the identification of new drugs and therapeutics which would retard its formation and protect against neuronal injury and death. |
| US08883492B2 |
Cell culture apparatus
A cell culture apparatus has four sections, including a cell culture chamber, refrigerator, control unit, and intermediate chamber. The cell culture chamber includes a culture vessel base as a holding member for holding and installing a culture vessel, a microscope for photographing a cell image within the culture vessel, and a drive base which has drive mechanisms such as a pump and a valve to be connected to a flow channel having a closed structure including a tank. With the drive base within the cell culture chamber as the center, the rotatable culture vessel is arranged in the horizontal direction and the refrigerator in which the culture medium base containing the cell fluid and culture medium is installed is arranged in the vertical direction. The arrangement configuration is space-saving and provides a short distance between the instruments. |
| US08883490B2 |
Fluorescence detector for microfluidic diagnostic system
The present technology provides for an fluorescent detector that is configured to detect light emitted for a probe characteristic of a polynucleotide. The polynucleotide is undergoing amplification in a microfluidic channel with which the detector is in optical communication. The detector is configured to detect minute quantities of polynucleotide, such as would be contained in a microfluidic volume. The detector can also be multiplexed to permit multiple concurrent measurements on multiple polynucleotides concurrently. |
| US08883486B2 |
Arrestin biosensor
The present invention relates to a novel biosensor. A resonance energy transfer (RET) biosensor comprising a beta(β)-arrestin tagged with a first and a second chromophore, wherein said first chromophore is a fluorophore and said second chromophore is a fluorophore or a bioluminophore is described. |
| US08883476B2 |
Mutant of propionyl-CoA transferase from Clostridium propionicum and preparing method for PLA or PLA copolymer using the same
Provided is a mutant of propionyl-CoA transferase from Clostridium propionicum that can convert lactate into lactyl-CoA with high efficiency in a method of preparing a polylactate (PLA) or PLA copolymer using microorganisms. Unlike conventional propionyl-CoA transferase which is weakly expressed in E. coli, when a mutant of propiony-CoA transferase from Clostridium propionicum is introduced into recombinant E. coli, lactyl-CoA can be supplied very smoothly, thereby enabling highly efficient preparation of polylactate (PLA) and PLA copolymer. |
| US08883474B2 |
Solubilized phospholipids for stabilizing nucleic acid polymerases
Compositions and methods are provided that relate to solubilized phospholipids and their use in stabilizing nucleic acid polymerases. For example, a phospholipid with a tail containing at least 8 carbons can be solubilized in the presence of an amphipathic molecule. |
| US08883469B2 |
Method for producing ethanol by fermentation from lignocellulosic biomass
The description relates to a method of producing bioethanol by separating lignin from a crushed lignocellulose biomass and obtaining cellulose and, if required, hemicellulose and additionally processing the cellulose or the mixture of cellulose and hemicellulose to form sugars and subsequently form bioethanol. The method is characterized in that crushed lignocelluloses biomass is treated with an alkanolamine for extracting the lignin therein, the lignin solution is separated, the residue containing cellulose/hemicellulose is converted to sugars without drying, and the sugars are fermented to obtain bioethanol. The raw cellulose (cellulose/hemicellulose), owing to its high reactivity, can easily be converted into sugar, which can be fermented to form bioethanol. |
| US08883468B2 |
1-hydroxy-octahydroazulenes as fragrances
(3S,5R)-3,8-dimethyl-5-(prop-1-en-2-yl)-octahydroazulen-1-ols, their use as flavor or fragrance ingredient, and a process of their production by oxidation in the presence of laccase. |
| US08883464B2 |
Methods for producing 3-hydroxypropionic acid and other products
This invention relates to metabolically engineered microorganism strains, such as bacterial strains, in which there is an increased utilization of malonyl-CoA for production of a chemical product, which includes 3-hydroxypropionic acid. |
| US08883463B2 |
Recombinant microorganism having ability to produce [lactate-co-glycolate] copolymer from glucose, and method for preparing [lactate-co-glycolate] copolymer using same
There is provided a recombinant microorganism having producibility of poly(lactate-co-glycolate) from glucose, and more particularly, a recombinant microorganism having producibility of poly(lactate-co-glycolate) without adding an exogenous glycolate precursor, and a method of preparing [poly(preparing lactate-co-glycolate)] using the same. According to the present invention, the poly(lactate-co-glycolate) in which the concentration of the glycolate fraction is high may be prepared at a high concentration without supplying exogenous glyoxylate. Therefore, the present invention may be effectively used for treatment. |
| US08883462B2 |
Triprenyl phenol compound, process for production of triprenyl phenol compound, and thrombolysis enhancer
A triprenyl phenol compound represented by the following formula (II) and (III) and having a thrombolysis-enhancing activity, and an efficient method for producing the triprenyl phenol compound. In formula (II) and (III), R1 represents an aromatic group having as a substituent or as a part of a substituent at least one member selected from the group consisting of a carboxyl group, a hydroxyl group, a sulfonic acid group and a secondary amino group, or an aromatic group which comprises a secondary amino group and may comprise nitrogen; R4 in the general formula (III) represents an aromatic amino acid residue represented by the general formula (III-1) below; X represents —CHY—(CH3)2Z; and Y and Z are respectively —H or —OH or together form a single bond: (III-1) wherein R5 represents a hydroxyl group which may be present or absent; and n represents an integer of 0 or 1. |
| US08883454B2 |
DNA polymerase fusions and uses thereof
The present invention discloses methods of using DNA polymerase fusions at high pH in PCR, DNA sequencing and mutagenesis protocols. |
| US08883453B2 |
Codon specific mutagenesis
Materials and methods are provided for replacing one or more amino acids in a polypeptide with an amino acid of choice to form mutant proteins. Both naturally and non-naturally occurring amino acids can be inserted. A population of mutant proteins can be created in which an amino acid residue has replaced an existing residue at random locations along the primary sequence of the protein. The provided techniques allow for the study of proteins and development of proteins with improved functionalities. |
| US08883450B2 |
Signal peptide, and use thereof for producing recombinant proteins
A use of a signal peptide for producing a recombinant polypeptide of interest in an expression system, the signal peptide includes at least 12 amino acids of formula (I): (X1)iX2X3X4SX5X6X7, wherein: X1 is a peptide containing from 3 to 6 amino acids, i equal to 0 or 1, X2 is a peptide containing from 3 to 9 hydrophobic amino acids, X3 is a peptide containing from 3 to 5 amino acids, the peptide including at least 3 contiguous or non-contiguous leucines X4 is a peptide containing from 2 to 5 amino acids chosen from Ala, Thr, Ser, Gln, Ile, Met, X5 is Ala or Val, X6 is Gln, Asn or His, X7 is Ala or Cys, provided that when the signal peptide originates from a natural precursor of a specific protein, the polypeptide of interest is different from the protein. |
| US08883449B2 |
Single-chain insulin
The present invention is related to single-chain insulin having insulin activity comprising a B- and an A-chain or a modified B- and A-chain connected by a connecting peptide of from 6-11 amino acids. The single-chain insulins will have biological insulin activity and an IGF-1 receptor affinity similar to or lower than that of human insulin and a high physical stability. The single-chain insulin may contain at least one basic amino acid residues in the connecting peptide. The single-chain insulins may also be acylated in one or more Lys residues. |
| US08883444B2 |
Peptide synthesis using enzymatic activation and coupling
The invention relates to a method for synthesizing a peptide by enzymatically preparing an ester or thioester from (i) an N-terminal protected amino acid or an N-terminal protected peptide where either can have a protected C-terminal ester group and (ii) an alcohol represented by the formula HO—CX2—Z or a thiol represented by the formula HS—CX2—Z, each X independently representing a halogen atom or a hydrogen atom; and Z represents an electron withdrawing group comprising at least one sp3-hybridized carbon comprising at least two substituents comprising a heteroatom directly attached to the at least one sp3-hybridized carbon or at least one sp2-hybridized carbon comprising one or two substituents comprising a heteroatom directly attached to the at least one sp2-hybridized carbon, and enzymatically coupling the prepared ester or thioester with an optionally C-terminal protected amino acid or with an optionally C-terminal protected peptide in a medium comprising 2 wt. % water or less. |
| US08883438B2 |
Method for diagnosing cell proliferation disorders having a neoactive mutation at residue 97 of isocitrate dehydrogenase 1
Methods and compositions for treating and evaluating subjects having a neoactive mutation at residue 97 of IDH1 or 137 of IDH2. |
| US08883437B2 |
Nitroreductase enzymatic substrates
The invention relates to the use of a compound having formula (I) as an enzymatic substrate for the detection of a nitroreductase activity, wherein: W1, W2, W3 and W4 are independently H, Br, Cl, F, I, alkyl, alkoxy, thiomethyl, perfluoroalkyl, nitro, cyano, carboxyl (including the esters or amides thereof) or any combination of same; n=0, 1 or 2; X is NR, CZ5Z6, S or O, R being H, alkyl, aralkyl, aryl, alkanoic or alkylsulphonic, Z5 and Z6 being an alkyl; Y is N or N+R, R being alkyl, aralkyl, aryl, alkanoic or alkylsulphonic; Z1, Z2, Z3 and Z4 are independently H, Br, Cl, F, I, alkyl, aryl, alkoxy, perfluoroalkyl, nitro, cyano, carboxyl, sulphonyl, including the sulphonyl or carboxyl amides or esters thereof, and the salts of same. |
| US08883433B2 |
Method for in vitro assay of soluble fibrin by generating specific degradation products
The invention concerns a method for assaying soluble fibrin in a sample, in which said sample is brought into the presence of a plasminogen activator with a high specificity for soluble fibrin (PA-Fb sp) and the soluble fibrin count in the sample is measured by measuring the difference between the count of fibrin degradation products obtained after degrading soluble fibrin with PA-Fb sp and the base count of fibrin degradation products determined before bringing the sample into the presence of PA-Fb sp. |
| US08883431B2 |
Compositions and methods for immunodominant antigens of Mycobacterium tuberculosis
Contemplated compositions, devices, and methods are drawn to various antigens from the pathogen M. tuberculosis and their use in vaccines, therapeutic agents, and various diagnostic tests. In particularly preferred aspects, the antigens are immunodominant and have quantified and known relative reactivities with respect to sera of a population infected with the pathogen, and/or have a known association with a disease parameter. |
| US08883422B2 |
Authentication method of dairy products
The present invention relates to a new method of establishing the authenticity and origin of dairy products, more specifically to the use of lactic acid bacterial strains having strain-specific insertion sequence elements as tools for marking dairy products (such as cheese) and identification thereof. The invention also extends to new lactic acid bacterial strains, their use in the production of dairy products as well as the dairy products containing these bacterial strains. |
| US08883418B2 |
Measurement of the immunological diversity and evaluation of the effects of a treatment through studying V(D)J diversity
The invention relates to a method for analyzing the diversity of the catalogue of T and/or B lymphocytes in an individual, based on the amplification, from a sample, of genomic DNA fragments by PCR multi-n-plexes, with n≧2, carried out with a combination of at least 3 primers defining at least 2 primer couples, each of which includes a primer specifically hybridizing upstream and/or in a given V or D gene and a primer specifically hybridizing downstream and/or in a given J gene, in order to obtain the amplification of at least two fragments characteristic of two distinct V-J or D-J rearrangements from each primer couple. The invention also relates to the applications of this method, in particular in the treatment follow-up or in the diagnosis and/or prognosis of certain diseases. |
| US08883416B2 |
Isolated reductive dehalogenase genes
The invention is directed to novel reductive dehalogenase genes encoding for reductive dehalogenases which are capable of dehalogenating halogenated organic compounds and may be useful in the bioremediation of pollutants. In particular, the invention provides an isolated polynucleotide of a novel vinyl chloride dehalogenase gene (bvcA). The novel vinyl chloride dehalogenase gene encodes a reductive dehalogenase that is capable of the complete reduction of vinyl chloride to ethene. |
| US08883412B2 |
Size standards for use in nucleic acid analysis
A size standard, kit includes a size standard, method of defining a size standard and method of analysis using a size standard. The size standard is intended to include size standard elements which have a size greater than and/or less than and/or different from the components of a sample which are to be sized. This means that the same characteristic unit, such as a dye, can be used to label the component and the size standard. A further characteristic unit, from amongst a limited number of such characteristic units is liberated from use only on size standards for use on components. The method is therefore particularly useful in multiplex amplification of STRs. |
| US08883408B2 |
Tissue implants for implantation and methods of preparing the same
A method is provided for preparing a tissue implant for implantation. The method includes harvesting a tissue material from a human or an animal donor, treating the tissue material in a nuclease-containing solution, and thereafter treating the tissue material with an alkaline alcohol solution. The nuclease-containing solution includes an antimicrobial. The alkaline alcohol solution comprises sodium hydroxide and ethanol. |
| US08883406B2 |
Method for using a purge ring with split baffles in photonic thermal processing systems
A method for supplying a first gas and a second gas using a purge ring in a photonic processing system includes arranging a first layer and a second layer to define a first plenum and a first baffle, arranging the second layer and a third layer to define a second plenum and a second baffle, receiving a first gas at the first plenum that flows through the first plenum and the first baffle to an inner region, and receiving a second gas at the second plenum that flows through the second plenum and the second baffle to the inner region. The second baffle is one of less restrictive and more restrictive than the first baffle. |
| US08883404B2 |
Process for producing a liquid ejection head
A process for producing a liquid ejection head including, on a substrate, a flow path forming member forming ejection orifices and a liquid flow path communicating therewith, including forming, on the substrate, a first layer of photosensitive resin; forming, on the first layer, a mask layer in which at least part of a side surface thereof has a light transmission distribution with a material capable of reducing transmission of light having a photosensitive wavelength of the resin; performing, for the first layer, exposure with the mask layer and development to form a flow path mold pattern having a taper angle θ satisfying 95°<θ, where θ is the angle between top and side surfaces in cross section of the pattern perpendicular to substrate surface; forming a coating resin layer to cover the pattern; patterning the resin layer to form the member; and removing the pattern to form the flow path. |
| US08883401B2 |
Lithographic printing original plate
A presensitized plate having a long press life and excellent resistance to scum and corrosive micro-stains and capable of on-press development is provided. The presensitized plate includes a photosensitive layer containing (A) a sensitizing dye, (B) a polymerization initiator, (C) a polymerizable compound, and (D) a binder polymer; and a protective layer which are formed on a support in this order. The support is prepared from an aluminum alloy plate containing intermetallic compound particles with a circle equivalent diameter of 0.2 μm or more at a surface density of 35,000 pcs/mm2 or more and aluminum carbide particles with a maximum length of 1 μm or more in an amount of up to 30,000 pcs/g. |
| US08883399B2 |
Ablation layer, photosensitive resin structure, and method for producing relief printing plate using the photosensitive resin structure
A photosensitive resin structure having an ablation layer for a photosensitive resin for a relief printing that is capable of being processed by infrared radiation and containing an anionic polymer, a relief printing plate is produced by drawing a pattern by irradiating the ablation layer with infrared radiation; exposing the pattern by irradiating the photosensitive resin layer with ultraviolet radiation; and removing the ablation layer and unexposed photosensitive resin layer with a developer. |
| US08883396B2 |
Resist composition and method of forming resist pattern
A resist composition containing a base component (A) which generates an acid upon exposure and exhibits changed solubility in a developing solution by the action of acid, wherein the base component (A) contains a copolymer (A1) having a structural unit (a0) containing a group represented by the following general formula (a0-1) or (a0-2), a structural unit (a11) containing an acid-decomposable group which exhibits increased polarity by the action of acid and contains a polycyclic group, and a structural unit (a12) containing an acid-decomposable group which exhibits increased polarity by the action of acid and contains a monocyclic group. Each of the groups —R3—S+(R4)(R5) and Mm+ in the formula has only one aromatic ring as a whole or has no aromatic ring. |
| US08883393B2 |
Printing form precursor for use as a recording element
The invention relates to an imaging element and a method of using the imaging element to form a recording element. The imaging element includes a composition sensitive to actinic radiation at a first wavelength and a photoluminescent tag that is responsive to radiation at a second wavelength different from the first wavelength. The photoluminescent tag can be used to authenticate the identity of the element, provide information about the element, and/or to establish one or more conditions in a device used to prepare the recording element from the imaging element. |
| US08883392B2 |
Compositions and methods for use in three dimensional model printing
A radiation curing composition suitable for building a three-dimensional object by a solid freeform method is disclosed. The composition includes one or more mono-functional monomers where a respective polymer has a Glass Transition Temperature higher than about 60° C., one or more di-functional oligomers where a respective polymer has a Glass Transition Temperature lower than about 40° C. and a phase separation inducing component. The phase separation may be induced during curing, resulting in a non-clear cured material having an improved impact strength and higher elongation, when compared to similar compositions without a phase separation inducing component. |
| US08883390B1 |
Method for creating a scratch-off document
A method for creating a scratch-off document having hidden information, the method includes providing a substrate; depositing a first layer of first toner particles on the substrate, wherein the first layer includes at least two thicknesses in which one region is thicker than the other region; depositing a second layer of toner particles on the first layer, wherein the first toner particles have a different thermal conductivity than the second toner particles; and applying heat to the first and second layers simultaneously so that the first layer adheres to the substrate in regions of the lesser thickness of the first toner particles and does not adhere in the regions of greater thickness of the first toner particles; wherein the first and second layers in the regions of greater thickness of the first toner layer can be removed thereby revealing hidden information. |
| US08883384B2 |
Binderless overcoat layer
Embodiments pertain to a novel imaging member, namely, an imaging member or photoreceptor comprising a binderless overcoat layer which exhibits substantially improved electrical performance, such as low residual potential and good electrical cyclic stability. The overcoat layer of the present embodiments is formed from a formulation comprising a small transport molecule, a crosslinking agent, an acid catalyst and a solvent. |
| US08883383B2 |
Charge transport layer comprising fluoroacyl arylamine
A photoreceptor charge transport layer comprising a film-forming material or binder with a fluoroacyl arylamine charge transport molecule is described. |
| US08883371B2 |
Hydrogen storage materials and hydrogen fuel cells
Hydrogen storage materials are provided that may be capable of a hydrogenated state and dehydrogenated state. The hydrogen storage material comprises a plurality of hydrogen storage molecular units. Each hydrogen storage molecular unit comprises a transition metal bonded to one or more elements from period 2 of the periodic table, wherein the hydrogen storage material includes at least 6.5% molecular hydrogen by weight when in the hydrogenated state and is stable at temperatures below about 200° C. and at pressures of about 1 atm and below. The hydrogen storage materials may be used in conjunction with fuel cells in portable electronic devices. |
| US08883369B2 |
Connected body connecting electrically between power generation parts of solid oxide fuel cells
Provided is a connected body connecting electrically between power generation parts of SOFCs, which has high connection strength and high reliability of electric connection. Adjacent two segmented-in-series type SOFCs (100), (100) are connected to each other with a metallic connecting member (300). A “left side end portion of the connecting member (300)” and an “interconnector (30) electrically connected to an air electrode (60) provided on the SOFC (100) on the left side” are electrically connected to each other with a connecting material (80), and a “right side end portion of the connecting member (300)” and the “interconnector (30) electrically connected to a fuel electrode (20) provided on the SOFC (100) on the right side” are electrically connected to each other with the connecting material (80). Both of the interconnectors (30), (30) to be respectively connected to both ends of the metallic connecting member (300) with the connecting material (80) are formed of dense conductive materials. |
| US08883368B2 |
Solid oxide fuel cell having rigidized support including nickel-based alloy
A fuel cell includes a separator sheet and a perforated support sheet connected to the separator sheet. The perforated support sheet and separator sheet are comprised of a nickel-based alloy. A porous layer is located between the separator sheet and the support sheet and provides an electrical connection between the separator sheet and the support sheet. |
| US08883366B2 |
Device with ceramic thin plate member and metal thin plate member
A device includes a ceramic thin plate member including a fired ceramic sheet; and a metal thin plate member having an outer shape larger than that of the ceramic thin plate member. An outer circumferential portion of the ceramic thin plate member is joined to the metal thin plate member. The ceramic thin plate member has through holes and a plurality of crease portions. Each crease portion has a ridge portion whose crest continuously extends from a joint portion between the ceramic thin plate member and the metal thin plate member toward an outer circumferential portion of the metal thin plate member. Since thermal stress due to a difference in thermal expansion between the metal thin plate member and the ceramic thin plate member can be relaxed through expansion of the crease portions, the ceramic thin plate member does not deform. |
| US08883365B2 |
Fuel cell stack discrete header
A fuel cell system comprises a main body including a first partial header and a fastening point. The main body is adapted to be coupled to a plurality of plates forming a fuel cell stack, allowing a single plate design to be used for multiple fuel cell stack lengths having a large differential of energy requirements, affording a durable alignment mechanism for the fuel cell stack, and providing integration flexibility for components and configurations of the fuel cell system. |
| US08883360B2 |
Burner reformer for fuel cell power generating system
A burner reformer is provided for a power generating system using fuel cell. A burner is contained inside the reformer. The reformer absorbs heat from the burner and other heat source to reduce heat loss and save connecting wires. The present invention avoids flashing back of hydrogen. When fuel is lean, flame would not easily die and the system can thus work stably. |
| US08883357B2 |
Ceramic material and process for producing the same
A ceramic material that can exhibit sufficient compactness and lithium (Li) conductivity to enable the use thereof as a solid electrolyte material for a lithium secondary battery and the like is provided. The ceramic material contains aluminum (Al) and has a garnet-type crystal structure or a garnet-like crystal structure containing lithium (Li), lanthanum (La), zirconium (Zr) and oxygen (O). |
| US08883354B2 |
Separators for electrochemical cells
Provided are separators for use in an electrochemical cell comprising (a) an inorganic oxide and (b) an organic polymer, wherein the inorganic oxide comprises organic substituents. Preferably, the inorganic oxide comprises an hydrated aluminum oxide of the formula Al2O3.xH2O, wherein x is less than 1.0, and wherein the hydrated aluminum oxide comprises organic substituents, preferably comprising a reaction product of a multifunctional monomer and/or organic carbonate with an aluminum oxide, such as pseudo-boehmite and an aluminum oxide. Also provided are electrochemical cells comprising such separators. |
| US08883351B2 |
Graphene and power storage device, and manufacturing method thereof
The formation method of graphene includes the steps of forming a layer including graphene oxide over a first conductive layer; and supplying a potential at which the reduction reaction of the graphene oxide occurs to the first conductive layer in an electrolyte where the first conductive layer as a working electrode and a second conductive layer with a as a counter electrode are immersed. A manufacturing method of a power storage device including at least a positive electrode, a negative electrode, an electrolyte, and a separator includes a step of forming graphene for an active material layer of one of or both the positive electrode and the negative electrode by the formation method. |
| US08883349B2 |
Alkaline secondary battery and method for manufacturing positive electrode material for alkaline secondary battery
An alkaline secondary battery includes a positive electrode containing a positive electrode material having nickel hydroxide, a cobalt-cerium compound containing cobalt and cerium, and a compound with at least one element of calcium, yttrium, europium, holmium, erbium, thulium, ytterbium and lutetium. Further, the positive electrode material is prepared by powder mixing nicked hydroxide particles, a cobalt-cerium compound, and a compound with at least one element of calcium, yttrium, europium, holmium, erbium, thulium, ytterbium and lutetium. |
| US08883348B2 |
Electrode for lithium ion secondary battery
An object of the present invention is to provide an electrode for a lithium ion secondary battery that can ensure a high level of safety even when exposed to severe conditions such as a nail penetration test or crush test, and exhibit excellent output characteristics.The present invention relates to an electrode for a lithium ion secondary battery having a material mixture containing active material particles capable of reversibly absorbing and desorbing lithium, and a current collector that carries the material mixture, wherein a surface of the current collector has recessed portions, and an area occupied by the recessed portions accounts for not less than 30% of an a material mixture carrying area of the current collector. The present invention further relates to an electrode for a lithium ion secondary battery wherein, in a cut surface obtained by simultaneously cutting a material mixture and a current collector vertically to an electrode plane, the maximum depth of recessed portions is not less than 1 μm, or a difference between an average thickness of a current collector and a maximum thickness of the current collector is not less than 0.35 μm. |
| US08883344B2 |
Electrolyte for lithium secondary battery and lithium secondary battery including the same
An electrolyte for a lithium secondary battery having flame retardancy, low negative electrode interfacial resistance, and excellent high temperature properties and life characteristics, and a lithium secondary battery including the same. An electrolyte for a lithium secondary battery of the present invention may include a non-aqueous organic solvent, a lithium salt, fluorinated ether or phosphazene, and a resistance-improving additive represented as the following chemical formula (1): FSO2—R1—SO2F [Chemical Formula 1] wherein R1 is a C1-C12 hydrocarbon unsubstituted or substituted with at least one fluorine. |
| US08883337B2 |
Support foot for battery pack, battery pack with the same and method of manufacturing the same
A support foot for a battery pack, a battery pack including the support foot and a method for manufacturing the battery pack are provided. The support foot is constructed with a first support part, and a second support part including a protrusion. The protrusion is inserted into the battery pack and is thermally welded to be attached to the battery pack, so that the support foot can be securely attached to the battery pack. |
| US08883335B2 |
Battery pack
A battery pack includes a battery module including a plurality of battery cells electrically connected to each other, a housing surrounding the battery module, and a sealing member interposed between the battery module and the housing. |
| US08883334B2 |
Battery device, electronic apparatus, and battery system
A battery to hold a battery cell can include a first surface, an end surface forming a corner edge with the first surface along an edge of the first surface in a lateral direction, and an output terminal provided at the corner edge formed by the end surface and the first surface. The output terminal can include electrode slits that are opened to both the end surface and the first surface, and the electrode slits include electrodes to output power from the battery cell. First and second grooves can be provided in the first surface that extend away from the corner edge, where the output terminal is provided between the grooves in the lateral direction. Step surfaces can be provided that are stepped with respect to the first surface, and that include chamfered portions. |
| US08883333B2 |
Flow and SOC determination using pump measurements
In one embodiment, a flow battery system includes a reactor, a first pump operably connected to a first electrolyte tank and to the reactor, a second pump operably connected to a second electrolyte tank and to the reactor, a memory including program instructions stored therein, and a controller operably connected to the first pump, the second pump, and the memory and configured to execute the program instructions to determine a first flow rate through the first pump based upon first pump operating parameters including a differential pressure across the first pump, control the first pump based upon the first flow rate, determine a second flow rate through the second pump based upon second pump operating parameters including a differential pressure across the second pump, control the second pump based upon the second flow rate. |
| US08883329B2 |
Hexagonal ferrite magnetic powder and method of manufacturing the same, and magnetic recording medium and method of manufacturing the same
An aspect of the present invention relates to a hexagonal ferrite magnetic powder manufactured by a glass crystallization method as well as having an average plate diameter ranging from 15 to 25 nm, an average plate ratio ranging from 2.0 to 2.8 and a coercive force (Hc) ranging from 159 to 279 kA/m. |
| US08883324B2 |
Aromatic amine derivative and organic electroluminescent device using same
Disclosed is an organic electroluminescence device in which an organic thin film which is composed of one or more layers including at least a light-emitting layer is interposed between a cathode and an anode. Since at least one layer of the organic thin film contains a novel aromatic amine derivative, which has an asymmetric structure wherein two different amine units are bonded through a linking group, by itself or as a component of a mixture, molecules are hardly crystallized, thereby improving the production yield of the organic electroluminescence device. This organic electroluminescence device has a long life. |
| US08883319B2 |
Coating blade
Improved coating blades are disclosed, as well as processes for manufacturing such blades. The inventive blades have an intermediate edge deposit effective to reduce heat transfer from a wear resistant top deposit to the blade substrate. In one embodiment, the intermediate layer is comprised of NiCr, possibly with embedded oxide particles. Suitably, the intermediate layer and the top deposit are applied by an HVOF process. It is also envisaged that the intermediate layer may be deposited by plasma spraying. The intermediate layer may comprise stabilized zirconia. |
| US08883317B2 |
Intermediate film for laminated glass and laminated glass
The present invention aims to provide an intermediate film for laminated glass which, in the case of being used for constituting a laminated glass, enables to improve the sound-insulating property in a high frequency range of the obtained laminated glass over a wide range of temperature; and a laminated glass. The intermediate film 1 for laminated glass of the present invention comprises a first layer 2 and a second layer 3 which is laminated on a first surface 2a of the first layer 2, each of the first and second layers 2 and 3 contains a polyvinyl acetal resin and a plasticizer, the absolute value of the difference between SP values of the polyvinyl acetal resin and the plasticizer contained in the first layer 2 is 0.5 or smaller, and the laminated glass of the present invention comprises first and second components for laminated glass and the intermediate layer 1 sandwiched between the first and second components for laminated glass. |
| US08883312B2 |
Manufacturing method of surface treated zinc oxide particles, surface treated zinc oxide particles, dispersion liquid and dispersion solid thereof, and base material coated with zinc oxide particles
Zinc oxide particles having high transparency in visible light and high shielding properties in a ultraviolet region, with surface treatment of inactivating photocatalytic activity applied thereto, and a dispersion thereof. A manufacturing method of surface treated zinc oxide particles, including: a first step of mixing a dispersion liquid with zinc oxide particles dispersed in a solvent, and silicone resin having polysiloxane bond with at least one or more silicon atoms having a silanol group (Si—OH) and/or alkoxy silyl group (Si—OR, wherein R is alkyl group); obtaining a mixed solution containing a surface treated zinc oxide particles precursor, with the silicone resin adsorbed on the surface of each zinc oxide particle and the solvent, and drying and solidifying the mixed solution by applying heat treatment thereto, to thereby manufacture a dried body; and a second step of pulverizing the dried body, to thereby manufacture the surface treated zinc oxide particles. |
| US08883304B2 |
Synthetic fiber
A synthetic fiber including core and sheath is provided. The sheath covers the core and includes a plurality of segment portions and a plurality of sacrificial portions. The plurality of sacrificial portions are connected to the plurality of segment portions, where the plurality of segment portions and the plurality of sacrificial portions are arranged alternately to each other on an outer surface of the core, and the material of the plurality of segment portions is different with that of the plurality of sacrificial portions. |
| US08883303B2 |
Particles comprising composite of para-aramid and additive material
The invention pertains to a method for making a polymer-additive composite particle from a dope by jet spinning the dope to obtain a pulp, fibril or fibrid, wherein the solvent of the dope is selected from N-methyl-2-pyrrolidone, N,N′-dimethylformamide, N,N′-dimethylacetamide, tetramethylurea, and 4 to 75 wt % of a composition consisting of 2 to 95 wt % of a para-aramid polymer and 5-98 wt % of a solid additive material, to a total of 100 wt %, and wherein the aramid polymer is dissolved in the solvent; or coagulating the dope by means of a rotor-stator apparatus in which the polymer solution is applied through the stator on the rotor so that the precipitating polymer-additive composite particle is subjected to shear forces while they are in a plastic deformable stage. |
| US08883300B1 |
Modification of wood-based lignocellulosic material
Porous wood-based lignocellulosic material is modified by incorporating into its pore matrix a bonded silica filling. An immobilized-silica precursor such as a water-glass solution of silica subunits or a colloidal silica is used to produce the filling, such as by immersion of the lignocellulosic material therein. The impermeable wood-based lignocellulosic material produced thereby is inflammable and impermeable to penetration by fluids and pests. |
| US08883299B2 |
Composition for use as non-stick coating
A substrate with a non stick surface which is obtained by sequentially applying on the substrate and curing of at least three coating layers. All coating layers comprise a fluorocarbon resin and some other resins, the basecoat layer and the topcoat layer comprise inorganic particles. |
| US08883296B2 |
Coating structure and method for forming the same
A coating structure and a method for forming the same where, by forming an aluminum oxide layer and a silicon dioxide layer between a product to be coated and a coating layer, durability, reliability and anti-corrosion of the coating layer can be improved and furthermore, product yield can also be improved. The coating structure formed on the surface of a product includes an aluminum oxide (Al2O3) layer formed on the surface of the product, a silicon dioxide (SiO2) layer formed on the surface of the aluminum oxide (Al2O3) layer, and a coating composition layer formed on the silicon dioxide (SiO2) layer. |
| US08883286B2 |
Honeycomb structure
A honeycomb structure includes a ceramic block including at least one honeycomb fired body. The at least one honeycomb fired body has cell walls and a peripheral wall. The peripheral wall is formed around the at least one honeycomb fired body. The peripheral wall of the at least one honeycomb fired body, which forms a periphery of the ceramic block, is a stepped peripheral wall provided with a level difference. The level difference includes a projected portion and a recessed portion in a cross section perpendicular to a longitudinal direction of the at least one honeycomb fired body. At least one of the projected portion and the recessed portion is formed by at least one of a curve line and a straight line in the cross section perpendicular to the longitudinal direction of the at least one honeycomb fired body by being subjected to chamfering. |
| US08883285B2 |
Sandwich-type, composite component such as motor vehicle component and unitary structural assembly utilizing same
A sandwich-type, composite component such as a motor vehicle component and unitary structural assembly utilizing same are provided. The component has a sealed, moisture-resistant, A-surface edge. The component includes a first outer layer having an A-surface, a second outer layer having a B-surface and a core positioned between the outer layers. The core has a large number of cavities. The outer layers are bonded to the core by press molding. An edge portion of the component is locally crushed by the press molding so that the layers are bonded together to form the sealed, moisture-resistant, A-surface edge. |
| US08883282B2 |
Electrode tape
An electrode tape, a solar module and methods for manufacturing the same are disclosed. The electrode tape includes an adhesive film and a conductive structure. The adhesive film includes a first adhesive surface and a second adhesive surface which faces an opposite direction to the first adhesive surface. The conductive structure is embedded in the adhesive film with a first contact point exposed on the first adhesive surface and a second contact point exposed on the second adhesive surface. The solar module includes a first solar cell and a second solar cell which are electrically connected with each other through the electrode tape. |
| US08883280B2 |
Polymeric material for an insulated container
A formulation includes a polymeric material, a nucleating agent, a blowing agent, and a surface active agent. The formulation can be used to form a container. |
| US08883277B2 |
Multiple glazing unit incorporating at least one antireflection film and use of an antireflection film in a multiple glazing unit
A multiple glazing unit with at least three substrates which are held together by a frame structure, in which at least two intermediate gas-filled cavities lie each between two substrates, at least one substrate has, on at least one face in contact with an intermediate gas-filled cavity, an antireflection film which is in a face-to-face relationship relative to said intermediate gas-filled cavity, with an insulating film having reflection properties for infrared and/or in solar radiation. |
| US08883274B2 |
Ink jet recording material
An ink jet recording material comprises at least two layers of ink-receptive layers mainly containing inorganic fine particles having an average secondary particle size of 500 nm or less on a resin-coated paper having a resin layer on at least one surface of a base paper, and the ink-receptive layer nearer to the support contains a pearlescent pigment. |
| US08883267B2 |
Vapor deposition apparatus, vapor deposition method, and method of manufacturing organic light-emitting display apparatus
A vapor deposition apparatus and method for efficiently performing a deposition process to form a thin film with improved characteristics on a substrate, and a method of manufacturing an organic light-emitting display apparatus. The vapor deposition apparatus includes a chamber including an exhaust port; a stage disposed in the chamber, and including a mounting surface on which the substrate is to be disposed; an injection portion including at least one injection opening through which a gas is injected in a direction parallel with a surface of the substrate on which the thin film is to be formed; and a plasma generator disposed apart from the substrate to face the substrate. |
| US08883265B2 |
Method of manufacturing magnetic recording medium and magnetic recording/reproducing device
Provided is a method of manufacturing a magnetic recording medium capable of manufacturing at a high productivity a useful magnetic recording medium having high surface smoothness and excellent head floating characteristics. Such a method of manufacturing a magnetic recording medium includes: forming a magnetic layer on a nonmagnetic substrate; and partially injecting ions into the magnetic layer to modify magnetic characteristics at a location of the magnetic layer where the ions are injected and to form magnetically separated magnetic recording patterns, in which, when partially injecting ions into the magnetic layer, a carbon film is formed on the surface of the magnetic layer, the carbon film is partially thinned by patterning, and ions are partially injected into the magnetic layer through locations where the carbon film is thinned. |
| US08883264B2 |
Method of powder coating and powder-coated fuser member
Methods for powder coating that include applying a powder coating composition to a substrate via an electrostatic gun. The powder coating composition includes a mixture of two or more materials having different densities, such as a mixture of aerogel particles and fluoropolymer-containing particles. The electrostatic gun can have a high-voltage generator that generates a negative polarity voltage between about 0 KV and about 100 KV during application of the powder coating composition, and the electrostatic gun can have a round spray nozzle. Methods of making fuser members using such powder coating methods, fuser members prepared by such methods, and methods of preparing low gloss images using such fuser members. |
| US08883263B2 |
Coated film manufacturing method and coating machine
A coated film manufacturing method and a coating machine are provided which can prevent deformation of a die coater due to evaporation of a coating liquid and prevent surface deficiency occurring when starting the coating. A coating machine is prepared which includes a die coater having a manifold, a slot communicating with the manifold, and a lip face formed at an end of the slot, a heat-insulating plate being disposed in a region below the lip face of the die coater and having a tapered top end portion, and a depressurizing chamber being disposed upstream in a web conveying direction from the die coater. The coating machine is made to stand by at a position for forming a clearance greater than a predetermined clearance between the coating machine and the web at the time of coating while flowing the coating liquid from the die coater. |
| US08883255B2 |
Process for producing resin-coated metal pigment
Disclosed is a process for producing a resin-coated metal pigment comprising 100 parts by weight of a metal pigment and 0.1 to 50 parts by weight of a resin, wherein the resin is attached on the surface of the metal pigment, the process comprising applying an ultrasonic vibration during resin coating treatment. |
| US08883253B2 |
Process for forming and devolatilizing brominated polybutadiene polymer particles
Brominated butadiene polymers are recovered from solution and formed into particles by spraying the solution onto a heated, mechanically agitated bed of seed particles. The droplets contact the seed particles in the bed and form a polymer layer on the outside of the seed particles, thereby enlarging them. The solvent is removed from the droplets after they make contact with seed particles in the bed. The process allows for the simultaneous removal of solvent and formation of somewhat large particles. The process forms at most small amounts of agglomerates and fines. |
| US08883250B2 |
Methods of rejuvenating sputtering targets
In various embodiments, a sputtering target initially formed by ingot metallurgy or powder metallurgy and comprising a sputtering-target material is provided, the sputtering-target material (i) comprising a metal, (ii) defining a recessed furrow therein, and (iii) having a first grain size and a first crystalline microstructure. A powder is spray-deposited within the furrow to form a layer therein, the layer (i) comprising the metal, (ii) having a second grain size finer than the first grain size, and (iii) having a second crystalline microstructure more random than the first crystalline microstructure. Spray-depositing the powder within the furrow forms a distinct boundary line between the layer and the sputtering-target material. |
| US08883248B2 |
Method for making touch panel
The present disclosure relates to a method for making a touch panel. The method includes following steps. A substrate is provided, wherein the substrate has a surface and defines two areas: a touch-view area and a trace area; applying an adhesive layer on the surface of the substrate. A carbon nanotube film is placed on a surface of the adhesive layer. The adhesive layer is solidified. An electrode and a conductive trace are formed on a surface of the carbon nanotube film so that part of the carbon nanotube film on the trace area is exposed from space between adjacent conductive lines of the conductive trace to form an exposed carbon nanotube film. The exposed carbon nanotube film is removed. |
| US08883246B2 |
Plasma activated chemical vapour deposition method and apparatus therefor
In plasma activated chemical vapour deposition a plasma decomposition unit is used that is arranged in or connected to a vacuum vessel having a relatively low pressure or vacuum, to which an operating gas is provided. Periodically repeated voltage pulses are applied between the anode and the cathode of the plasma decomposition unit in such a manner that pulsed electric discharges are produced between the cathode and the surrounding anode of the plasma decomposition unit. The anode is arranged in a special way so that at least a portion thereof will obtain only an electrically conductive coating or substantially no coating when operating the unit. For that purpose, the anode includes a portion located in the direct vicinity of the free surface of the cathode. The portion is a flange or edge portion which is located or extends over margins of the free surface of the cathode. In that way, the anode will include a portion that is shielded for direct coating with particles from the plasma formed and that hence will obtain e.g. substantially no dielectric coating at all. |
| US08883244B2 |
Method for electrostatic coating of a medical device balloon
A method for electrostatic coating of medical devices such as stents and balloons is described. The method includes applying a composition to a polymeric component of a medical device which has little or no conductivity. The polymeric component could be a material from which the body or a strut of the stent is made or could be a polymeric coating pre-applied on the stent. The polymeric component could be the balloon wall. A charge can then be applied to the polymeric component or the polymeric component can be grounded. Charged particles of drugs, polymers, biobeneficial agents, or any combination of these can then be electrostatically deposited on the medical device or the coating on the medical device. One example of the composition is iodine, iodine, iodide, iodate, a complex or salt thereof which can also impart imaging capabilities to the medical device. |
| US08883239B2 |
Clarification and selective binding of phenolic compounds from liquid foodstuff or beverages using smart polymers
The present invention corresponds to a method for the removal of unwanted phenolic compounds from foodstuffs, more particularly beverages. The method comprising contacting a selected polymer with the foodstuff. In a particular embodiment, the polymers are selected among polyaniline (PANI), polyaniline emeraldine base (PANI-EB) and polyaniline emeraldine salt (PANI-ES) polymers, or the polymers are selected among polyamidoamine (PAMAM) dendrimers functionalized with polyaniline (PANI), polyaniline emeraldine base (PANI-EB) and polyaniline emeraldine salt (PANI-ES) polymers. |
| US08883236B2 |
Wrapping for food products to be cooked in an oven
A packaged food product, comprising a wrapping (1) entirely made of coating-free transpiring paper material and a product (100) to be cooked or heated received therein, wherein the wrapping (1) itself is apt to be exposed to a heat source jointly to the product. |
| US08883227B2 |
Plant pathogen inhibitor combinations and methods of use
Combinations, compositions and methods of use for modulating plant pathogen infection using plant extracts containing anthraquinone derivatives which induce resistance to plant phytopathogens and an antimicrobial agent, a biological control agent and/or a surfactant having fungicidal activity. |
| US08883226B2 |
Pharmaceutical composition for the prevention and treatment of inflammatory disease or asthma containing an extract of Decaspermum fruticosum
A pharmaceutical composition for the prevention and treatment of inflammatory disease or asthma comprising the extract of Decaspermum fruticosum as an active ingredient. The extract of Decaspermum fruticosum of the present invention inhibited the increase of eosinophils in bronchoalveolar lavage fluid of the ovalbumin induced asthma animal model, had the activity of inhibiting the secretions of immunoglobulin and chemokine (Eotaxin) in bronchoalveolar lavage fluid and blood, and inhibited the secretions of NO and TNF-α in macrophages. Therefore, the extract of Decaspermum fruticosum of the present invention can be effectively used as an active ingredient of a pharmaceutical composition for the prevention and treatment of inflammatory disease or asthma, and of a health functional food for the prevention and improvement of inflammatory disease or asthma. |
| US08883221B2 |
Micronutrient combination product for use as a dietetic food supplement in age-related macular degeneration
Micronutrient combination product, wherein the micronutrient combination product comprises zeaxanthin, lutein, zinc and copper. |
| US08883219B2 |
Nutritional compositions with coated lipid globules
The present invention relates to a nutritional composition for infants and/or toddlers comprising a lipid component which has a lipid globules coated with phospholipids. The composition is used for increasing bone mineral content, bone mineral density, preventing osteoporosis, and/or preventing ostopenia. |
| US08883216B2 |
Methods and ceramic nanoparticle compositions for heavy metal removal and for oral delivery of desirable agents
Compositions and methods for heavy metal remediation are disclosed. The compositions contain ceramic nanoparticulate cation exchangers specific for at least one heavy metal as well as at least one carrier, typically a thickener, a gel forming agent and/or a cross-binding agent. The compositions may also contain chelating agents as well as beneficial agents such as vitamins and pharmaceuticals, with or without the ceramic nanoparticulate cation exchangers. |
| US08883214B2 |
Implantable delivery vehicle for ocular delivery of muscarinic antagonists
The present invention provides compositions and methods for treating ocular disorders such as myopia. |
| US08883207B2 |
Controlled release carvedilol formulation
A controlled release carvedilol formulation for less frequent, preferably once daily administration is described. The controlled release formulation comprises a therapeutically effective amount of carvedilol or a pharmaceutically acceptable salt thereof, a matrix forming polymer, a solubility enhancer and a pharmaceutically acceptable carrier. In one embodiment, a controlled release formulation having a therapeutically effective amount of carvedilol is contained in two or more subunits having different release profiles. The controlled release formulation is usable in the treatment and/or prophylaxis of one or more conditions such as cardiovascular disorders. |
| US08883205B2 |
Microtablet-based pharmaceutical preparation
A pharmaceutical preparation consisting of various microtablets containing ingredients. The microtablets have the same form and the same weight. |
| US08883202B2 |
Lipid compositions
Disclosed herein are lipid compositions comprising a cationic lipid of formula (I), a neutral lipid, a sterol and a PEG or PEG-modified lipid, wherein formula (I) is (F). Also disclosed are methods of producing the cationic lipid of formula (I). |
| US08883198B2 |
Transdermal rivastigmine therapeutic system
The invention relates to transdermal therapeutic systems (TTS) comprising a backing, a reservoir layer containing at least one pharmaceutical active ingredient, and an adhesive. Said transdermal therapeutic systems are characterized in that they are able to continuously adhere to the surface of the skin over a long period of time. During said long period of time, a) there is at least one time interval during which the TTS adhering to the surface of the skin is intensively exposed to water, and b) the active ingredient is transdermally released. The invention also relates to a method for the continuous transdermal release of at least one pharmaceutical active ingredient over a long period of time. |
| US08883196B2 |
Transdermal hormone delivery system: compositions and methods
A transdermal hormone delivery system (THDS) is disclosed. The THDS is useful for control of fertility and as therapy for a variety of diseases and conditions treatable by robust delivery of progestin and estrogen hormones, particularly the progestin, levonorgestrel. The THDS comprises a backing layer, an adjoining adhesive polymer matrix comprising an effective amount of at least a progestin hormone, delivery of which is enhanced by one or more skin permeation enhancing agents present in pre-determined amounts. The THDS is capable of providing effective daily doses of progestin and estrogen hormones from a small surface area in contact with the skin, e.g., less than 20 square centimeters. Methods of fertility control and various types of hormone replacement therapy utilizing the THDS are also disclosed. |
| US08883192B2 |
Compositions and methods for reducing or preventing obesity
Compositions useful for weight management in an animal are disclosed. The compositions comprise one or more isoflavones or isoflavone metabolites, and in some embodiments include conjugated linoleic acid, and/or L-carnitine. Also disclosed are methods useful for weight management in an animal utilizing compositions comprising one or more isoflavones, conjugated linoleic acid, and/or L-carnitine. Preferably, the compositions and methods employ a combination of one or more isoflavones, or a combination of one or more isoflavones in conjunction with conjugated linoleic acid, and L-carnitine. |
| US08883186B2 |
Coatings for drug delivery devices
A polymer coating for medical devices based on a polyolefin derivative. A variety of polymers are described to make coatings for medical devices, particularly, for drug delivery stents. The polymers include homo-, co-, and terpolymers having at least one olefin-derived unit and at least one unit derived from vinyl alcohol, allyl alcohol and derivatives thereof. |
| US08883185B2 |
Hydrogel implants with varying degrees of crosslinking
The present disclosure relates to a hydrogel composition and methods of using the same. The hydrogel composition may include precursors that react with each other upon contact as well as precursors that react upon contact with an initiator. In embodiments, the resulting hydrogels may have varying levels of crosslinking with both denser and less dense regions. |
| US08883184B2 |
Methods and compositions for regenerating connective tissue
Connective tissue regenerative compositions and methods of repairing and regenerating connective tissue using such compositions are provided. The compositions generally comprise a bioactive hydrogel matrix comprising a polypeptide, such as gelatin, and a long chain carbohydrate, such as dextran. The hydrogel matrix may further include polar amino acids, as well as additional beneficial additives. Advantageously, the compositions include further components, such as osteoinductive or osteoconductive materials, medicaments, stem or progenitor cells, and three-dimensional structural frameworks. The compositions are useful for regenerating connective tissue, and can be administered to an area having injury to, or a loss of, connective tissue, such as bone, cartilage, tendon, and ligament. |
| US08883181B2 |
Compositions for treating plant pathogens
The present invention provides formulations and methods for preventing, suppressing, treating, or controlling pre- or post-harvest disease or decay in plants. In the inventive method, plants are contacted with a formulation including an antagonistic microorganism and a booster composition. The booster composition generally includes about 3 parts Kaolin clay, about 1 part yeast, about 1 part Yucca plant extract, and about 1 part calcium-source material. The antagonistic microorganism may be included in an amount of between about 0.02 parts and about 0.5 parts by weight of the formulation, with about 0.04 parts antagonistic microorganism being preferred in testing to date. The formulation is typically applied to the above ground structures of the plant, including its leaves, flowers, stems, trunk, blossoms and fruit. |
| US08883176B2 |
Smooth, high solids tablet coating composition
The invention describes a coating composition comprising an effective amount of a water-soluble cellulose ether, a poly(N-vinyl pyrrolidone-co-vinyl acetate) copolymer, a film-forming agent based on D-glucose, and a plasticizer. |
| US08883175B2 |
Block copolymers of acrylates and methacrylates with fluoroalkenes
A block copolymer comprising a fluorinated block and a non-fluorinated block and method of making the block copolymer are provided. Also provided herein are a coating on an implantable device comprising the block copolymer and method of using the implantable device. |
| US08883174B2 |
Compositions for stimulation of mammalian innate immune resistance to pathogens
Embodiments of the invention are directed to methods of treating, inhibiting or attenuating a microbial infection in an individual who has or is at risk for developing such an infection, comprising the step of administering an effective amount of a TLR9 agonist and a TLR 2/6 agonist to the individual. |
| US08883173B2 |
Synthetic antigenic peptides and lipopeptides derived from Mycobacterium avium subsp. paratuberculosis
The current invention relates to the diagnosis and treatment of diseases resulting from infections by Mycobacterium avium subsp. paratuberculosis. In particular the invention relates to the use of an antigen selected among (a) a synthetic peptide 5P having the following formula: DPhe-NMeVal-Ile-Phe-Ala-OMe (SEQ ID NO: 1); (b) a lipopeptide L5P consisting of the synthetic peptide a) wherein the N-terminal phenylalanine residue is N-acylated with an eicosanoic acid acyl chain; (c) a variant of peptide a) or lipopeptide b) able to react with anti-Mycobacterium paratuberculosis antibodies; for in vitro detection or quantification of specific anti-Mycobacterium paratuberculosis antibodies in a biological sample. |
| US08883172B2 |
Chemically modified peptides with improved immunogenicity
The invention provides processes for improving the ability of a peptide to stimulate an immune response, comprising exposing the peptide to a chemical modifying agent. It further provides compositions comprising an antigenic peptide, wherein the peptide has been treated with a chemical modifying agent to improve its ability to stimulate an immune response. It also provides methods of stimulating an immune response in a mammal, comprising administering to the mammal an effective amount of a vaccine. |
| US08883169B2 |
Immunogen platform
Aspects of the present invention relate to chimeric polypeptides including HCV NS3/4A sequences and T-cell epitopes. Embodiments include nucleic acids encoding the chimeric NS3/4A polypeptides, the encoded polypeptides, compositions containing said nucleic acids, compositions containing said chimeric polypeptides, as well as methods of making and using the aforementioned compositions including, but not limited to medicaments and vaccines. |
| US08883165B2 |
Modified peptide vaccine derived from influenza M2
A modified peptide derived from matrix protein 2 (hereinafter also referred to as “M2”), one of surface layer proteins of influenza virus, and a method for utilization of the modified peptide are provided. A peptide (hereinafter also referred to as “M2eC peptide”) that is made up by inserting cysteine residue(s) into a peptide (hereinafter also referred to as “M2e”) consisting of 23 amino acid residues of from positions No. 2 to No. 24 of M2 in influenza virus type A, a fusion protein consisting of said modified peptide and a polypeptide, an influenza vaccine comprising said modified peptide or said fusion protein as an active ingredient, a device which can be delivered into the body comprising said influenza vaccine, a nucleic acid fragment consisting of a nucleotide sequence encoding the amino acid sequence of said modified peptide or said fusion protein, an expression vector in which said nucleic acid fragment is incorporated, a host in which said expression vector is introduced, and an antibody that has a protective effect against influenza virus. |
| US08883162B2 |
Multivalent antibody complexes targeting IGF-1R show potent toxicity against solid tumors
The present invention concerns methods and compositions comprising an anti-IGF-1R antibody or fragment thereof for treatment of cancer or autoimmune disease. Preferably, the cancer is renal cell carcinoma, breast cancer or pancreatic cancer. The anti-IGF-1R antibody or fragment may be part of a complex, such as a DOCK-AND-LOCK™ (DNL™) complex. Preferably, the DNL™ complex also comprises a second antibody, a second antibody fragment, an affibody or a cytokine. More preferably, the cytokine is interferon-α2b. Most preferably, the second antibody, second fragment or affibody binds to IGF-1R, TROP2 or CEACAM6. The anti-IGF-1R antibody or complex may be administered alone or in combination with a therapeutic agent, such as an mTOR inhibitor. |
| US08883160B2 |
Dock-and-lock (DNL) complexes for therapeutic and diagnostic use
The prediction of protein function as well as the reconstruction of evolutionary genesis employing sequence comparison at large is still the most powerful tool in sequence analysis. Due to the exponential growth of the number of known protein sequences and the subsequent quadratic growth of the similarity matrix, the computation of the Similarity Matrix of Proteins (SIMAP) becomes a computational intensive task. The SIMAP database provides a comprehensive and up-to-date pre-calculation of the protein sequence similarity matrix, sequence-based features and sequence clusters. As of September 2009, SIMAP covers 48 million proteins and more than 23 million non-redundant sequences. Novel features of SIMAP include the expansion of the sequence space by including databases such as ENSEMBL as well as the integration of metagenomes based on their consistent processing and annotation. Furthermore, protein function predictions by Blast2GO are pre-calculated for all sequences in SIMAP and the data access and query functions have been improved. SIMAP assists biologists to query the up-to-date sequence space systematically and facilitates large-scale downstream projects in computational biology. Access to SIMAP is freely provided through the web portal for individuals (http://mips.gsf.de/simap/) and for programmatic access through DAS (http://webclu.bio.wzw.tum.de/das/) and Web-Service (http://mips.gsf.de/webservices/services/SimapService2.0?wsd1). |
| US08883159B2 |
Antibodies against CDCP1 for the treatment of cancer
The present invention relates to antibodies against human CDCP1 binding to the same epitope as CUB4 (Deposition No. DSM ACC2551) for the treatment of cancer. |
| US08883158B2 |
Compositions and methods for antibodies targeting complement protein C5
The present invention relates to antibodies targeting complement protein C5 and compositions and methods of use thereof. |
| US08883156B2 |
Purified antibody composition
The invention provides a method for producing a host cell protein-(HCP) reduced antibody preparation from a mixture comprising an antibody and at least one HCP, comprising an ion exchange separation step wherein the mixture is subjected to a first ion exchange material, such that the HCP-reduced antibody preparation is obtained. |
| US08883155B2 |
Methods for treating hematopoietic malignancies
The present invention relates to methods for treating neoplasias in a mammalian subject. In particular, the invention provides methods for treating lymphomas, including forms of non-Hodgkin lymphoma. In one embodiment, these methods involve reducing tumor necrosis factor signaling. |
| US08883148B2 |
Prevention of joint destruction
A method for treating, preventing or reducing the risk of joint destruction in a subject who suffers from a joint or musculoskeletal disease. The method comprises administering a histone deacetylase (HDAC) inhibitor or in conjunction with other agents to inhibit degradation and resorption of cartilage and bone in the joint. |
| US08883132B2 |
Cosmetic compositions comprising a polar modified polymer and a tackifier
The invention relates to a cosmetic composition comprising at least one polar modified polymer and at least one tackifier, as well as to methods of using such compositions. |
| US08883129B2 |
Enhanced efficacy antiperspirant active
An enhanced efficacy aluminum only salt active. The method for making such active comprises the steps of (a) providing an aqueous solution of an aluminum salt having a Band III polymer concentration of at least about 20%; (b) adding to the aqueous solution of step (a) an aqueous solution of a monomeric aluminum salt to form a mixture; and (c) rapidly drying the mixture to form a product powder. The active comprises an aluminum only salt having a Band III polymer concentration of at least about 20%, an aluminum to anion ratio of from about 1.1:1 to about 1.8:1 and a level of monomeric aluminum of from about 2% to about 20% of the total aluminum. |
| US08883127B2 |
Bleaching/highlighting composition containing calcium salts
The present invention relates to bleaching composition for keratin fibres, especially human hair, comprising at least one compound with bleaching and/or highlighting effect and a calcium salt. Further object of the present invention is the use of at least one calcium salt in a bleaching and/or highlighting composition for keratin fibres, especially for human hair, comprising at least one compound with bleaching and/or highlighting effect for preventing temperature increase going above 40° C., preferably above 45° C. and more preferably above 50° C. in a period of at least 60 min after mixing water free bleaching and/or highlighting composition and oxidizing lotion. |
| US08883121B2 |
Oral preparation useful in measurement capacity to metabolize pyridine
An object of the present invention is to provide an oral preparation that can be used to diagnose the existence or degree of pyridine metabolic capacity disorder, pyrimidine metabolic rate, etc., with high accuracy and with little variation due to individual differences. The oral preparation is prepared using a powder material obtained by mixing and pulverizing (a) an isotope-labeled compound and/or a pyrimidine metabolite compound and (b) a sugar and/or a sugar alcohol. |
| US08883119B2 |
Process for the preparation of zeolites having CHA structure
A process for the preparation of zeolites having CHA framework structure and a composition comprising the molar ratio (n Si02):X203, wherein X is a trivalent element, and wherein n is at least 10, the process comprising (i) preparation of an aqueous solution containing at least one source for X203, wherein X is selected from Al, B, Ga, and a mixture of two or more, and at least one source for Si02, at least one organic structure directing agent (SDA) other than Tetramethylammonium hydroxide (TMAOH), acting as a template for the CHA structure, and Tetramethylammonium hydroxide (TMAOH), wherein the SDA or mixtures thereof are employed in such amounts that the aqueous solution in (i) exhibits a molar ratio of SDA:TMAOH of 0.01 to 5; (ii) hydrothermal crystallization of the aqueous solution according to (i); wherein the aqueous solution of (i) contains copper in an amount less than 0.005 Cu:((n O2):X2O3) where n is in the range of 10 to 50. |
| US08883114B2 |
Production of ultra-thin nano-scaled graphene platelets from meso-carbon micro-beads
A method of producing nano-scaled graphene platelets (NGPs) having an average thickness no greater than 50 nm, typically less than 2 nm, and, in many cases, no greater than 1 nm. The method comprises (a) intercalating a supply of meso-carbon microbeads (MCMBs) to produce intercalated MCMBs; and (b) exfoliating the intercalated MCMBs at a temperature and a pressure for a sufficient period of time to produce the desired NGPs. Optionally, the exfoliated product may be subjected to a mechanical shearing treatment, such as air milling, air jet milling, ball milling, pressurized fluid milling, rotating-blade grinding, or ultrasonicating. The NGPs are excellent reinforcement fillers for a range of matrix materials to produce nanocomposites. Nano-scaled graphene platelets are much lower-cost alternatives to carbon nano-tubes or carbon nano-fibers. |
| US08883112B2 |
Carbon material and method for producing same
A porous carbon material having excellent graphite crystallinity, good carrier mobility and proper porosity, a porous carbon material having edges of carbon hexagonal planes located on outer surfaces of particle and structure, and flaky graphite being similar to graphene are produced.By subjecting a carbon material, in which a closed-pore-ratio and an amount of remaining hydrogen in the material are set to be within a proper range, to hot isostatic pressing treatment, a vapor phase growth reaction of graphite is generated in closed pores as nuclei using hydrogen and hydrocarbon generated from the carbon material, thereby producing a large amount of targeted porous carbon material at low cost. Flaky graphite being similar to graphene is produced by applying physical impact to the obtained porous carbon material or by generating a graphite intercalation compound using the porous carbon material as a host and then quickly heating the compound. |
| US08883111B2 |
Method for producing neopentasilanes
The invention relates to a method for producing neopentasilanes of the general formula (1) Si(SiR3)4 (1), wherein silicon compounds of the general formula (2) R3Si—(Si—)xSiR3 (2), wherein R is selected from H, Cl, Br, and I and x stands for a nonnegative integer up to 5, are reacted in the presence of ether compounds (E). |
| US08883107B2 |
Air pollution control system, air pollution control method, spray drying device of dewatering filtration fluid from desulfurization discharged water, and method thereof
To include a boiler 11 that burns fuel F, an air heater 13 that recovers heat of flue gas 18 from the boiler 11, a first precipitator 14 that reduces dust in the flue gas 18 after heat recovery, a desulfurizer 15 that reduces sulfur oxides in the flue gas 18 after dust reduction by an absorbent, a dewaterer 32 that reduces gypsum 31 from desulfurization discharged water 30 discharged from the desulfurizer 15, a spray drying device 34 including an atomizer that atomizes a dewatering filtration fluid 33 discharged from the dewaterer 32, and a flue-gas introducing line L11 that introduces a part of the flue gas 18 into the spray drying device 34. |
| US08883104B2 |
Gas stream multi-pollutants control systems and methods
In some embodiments, the invention provides systems and methods for removing carbon dioxide and/or additional components of waste gas streams, comprising contacting the waste gas stream with an aqueous solution, removing carbon dioxide and/or additional components from the waste gas stream, and containing the carbon dioxide and/or additional components, in one form or another, in a composition. In some embodiments, the composition is a precipitation material comprising carbonates, bicarbonates, or carbonates and bicarbonates. In some embodiments, the composition further comprises carbonate and/or bicarbonate co-products resulting from co-processing SOx, NOx, particulate matter, and/or certain metals. Additional waste streams such as liquid, solid, or multiphasic waste streams may be processed as well. |
| US08883103B1 |
Catalytic converter for treating ionized exhaust
A method for treating exhaust from an engine. The method includes activating an exhaust ionizer in receipt of the exhaust when temperature of a catalyst of a selective catalytic converter, which is in communication with the exhaust ionizer so as to receive exhaust from the exhaust ionizer, is equal to or above an effective temperature. The method further includes deactivating or maintaining the exhaust ionizer in a deactivated state when temperature of the catalyst is below the effective temperature. |
| US08883102B1 |
Methods for controlling nitrous oxide emissions
Systems and methods for controlling nitrous oxide emissions are described. In one particular example, nitrous oxide formed in the exhaust system of a diesel hybrid vehicle is routed through an oxidation catalyst heated by an external source such as an electric heater. Then, the catalyst is heated from the external source to reduce nitrous oxide formation within the exhaust system by increasing the catalyst temperature above a temperature range associated with nitrous oxide generation. |
| US08883101B2 |
Method for operating an exhaust gas system for an internal combustion engine
A method for operating an exhaust gas system for an internal combustion engine, in which the exhaust gas system includes at least one first catalytic coating and at least one second catalytic coating, the second catalytic coating being situated in the exhaust gas flow downstream from the first catalytic coating. An additional quantity of hydrocarbons is occasionally introduced into the exhaust gas upstream from the first catalytic coating so that a heat-generating reaction may take place in the second catalytic coating. With the aid of at least one temperature sensor and/or at least one hydrocarbon sensor and/or at least one lambda sensor upstream and/or downstream from the second catalytic coating, at least one property of the exhaust gas is ascertained which characterizes a reaction of the second catalytic coating due to the additional quantity of hydrocarbons. |
| US08883099B2 |
Control of wet scrubber oxidation inhibitor and byproduct recovery
The present disclose is directed to a method for controlling iodine levels in wet scrubbers, and, in particular, recirculating wet scrubbers by removing the iodine from the scrubbing solution, such as by using ion exchange, absorption, adsorption, precipitation, filtration, solvent extraction, ion pair extraction, and an aqueous two-phase extraction. |
| US08883098B2 |
Precipitated calcium carbonate pigment, especially for use in inkjet printing paper coatings
Novel and innovative PCC pigments, having a reduced production cost, able to be used in a paper coating formulations to manufacture coated high-quality matt papers, in particular for inkjet applications. Process for the preparation of same, using a reduced flow rate of a carbon dioxide-containing gas in the PCC carbonation step, which produces stable, porous, agglomerates of PCC featuring unique properties and structure, this step being followed by an upconcentration step to increase the solids content. |
| US08883094B2 |
Detection of analtyes using metal nanoparticle probes and dynamic light scattering
Disclosed herein are systems and methods for detecting Chemical Species, Biomolecules and Biotargets (Analytes) using receptor functionalized metal nanoparticles and Dynamic Light Scattering. |
| US08883093B2 |
Sealing of reaction cuvettes for bioaffinity assays
The invention relates to a piercable hermetic cover (2) for a bioassay cartridge (4) with at least one reaction chamber (6). Characteristic for the invention is that: the cover (2) comprises at least a top layer (8), a middle layer (10), a bottom layer (12), and sites intended for piercing (14); and the cover (2) has, at the sites (16) intended for piercing, a hollow space (18) between the top layer (14) and the bottom layer (12). The present invention also relates to a system (20) comprising a bioassay cartridge (4) and a cover (2) for the cartridge (4). The present invention further relates to use of the cover (2) for covering the cartridge (4). |
| US08883084B2 |
Siloxane removal via silicate formation for lifetime extension of photocatalytic devices
A photocatalytic device for reacting with volatile organic compounds includes a photocatalyst and at least one additive, such as hafnium oxide and zirconium oxide, that is capable of forming a stable silicate with silicon dioxide. The additive reacts with volatile silicon-containing compounds to form stable silicate compounds. As a result, the silicon-containing compounds are unavailable for deactivation of the photocatalyst. |
| US08883083B2 |
Air cleaner filter system capable of nano-confined catalytic oxidation
The present invention is an air cleaner that uses molecular sieves, such as zeolite or other microporous/nanoporous crystalline materials with pore sizes ranging from 4 Å to 20 Å, as a filter to remove contaminant gas. The contaminants are adsorbed into the porous material along with ions clusters, or any other oxidant generated by a generating device within the system. The contaminant gas is then catalytically decomposed in the confined space of the pore. In one embodiment, transition metal is incorporated into the porous material, and a heater is installed to substitute or accompany the oxidant-generating device. When the heater is turned on, the contaminant is decomposed within the pores of the materials with the transition metals acting as catalysts. Ultimately, the non-harmful byproducts are the small sized water molecutes and carbon dioxide molecules. Growth of bacteria is also suppressed under a clean and dry condition. |
| US08883079B2 |
Aquatic environment water-quality monitor having a submersible chemical indicator wheel
A water-quality monitoring system for an aquatic environment that includes a monitoring unit and a chemical indicator wheel designed and configured to be submerged in the water being monitored. The chemical indicator wheel includes a holder that supports a number of chemical indicators selected for use in measuring levels of constituents of the water. When in use, the wheel is drivingly engaged with a monitoring/measuring unit that includes at least one reader for reading the chemical indicators. In some embodiments, each apparatus includes a plurality of immobilized-dye-based chemical indicators that undergo an optically detectable physical change as levels of one or more constituents of the water change. Also disclosed are a variety of features that can be used to provide the monitoring system with additional functionalities. |
| US08883074B2 |
Method for broad spectrum, low residue disinfection with a small droplet hydrogen peroxide-based aerosol
The present invention discloses a method for disinfecting a space by applying an aqueous disinfecting composition as a fine aerosol having a droplet size wherein 50% of the droplets have a diameter of at the most 100 μm to a space and leaving the space to air-dry, the aqueous composition comprising: a. hydrogen peroxide in a concentration of 1 to 10% (w/w); b. acyclic carboxylic acid or salt thereof in a concentration of 0.01 to 2% (w/w); c. a humectant in a concentration of 0.05% to 15% (w/w). |
| US08883073B2 |
Method of using sulfur-based corrosion inhibitors for galvanized metal surfaces
A composition and method for inhibiting white rust formation on galvanized surfaces. The composition includes thiols, polymeric dithiocarbamates, and xanthates. The composition may be introduced onto the galvanized surface, especially in an industrial water system, using a variety of different methods or programs including integrating with current programs or developing a new program. |
| US08883072B2 |
Ni-base alloy, high-temperature member for steam turbine and welded rotor for turbine using the same, and method for manufacturing the same
The present invention provides, in a γ′ phase precipitation strengthening type Ni-base alloy, an alloy excellent in heat treatment capability and weldability and suitable for joint with a ferritic steel. Further, the present invention provides a welded turbine rotor having the strength, ductility, and toughness simultaneously over the whole welded structure when a precipitation strengthening type Ni-base alloy having a heatproof temperature of 675° C. or higher is joined to a ferritic steel.A Ni-base alloy according to the present invention contains cobalt, chromium, aluminum, carbon, boron, and at least either tungsten or molybdenum with the remainder being nickel and inevitable impurities, having an alloy composition including 12 to 25 percent by mass of Co, 10 to 18 percent by mass of Cr, 2.0 to 3.6 percent by mass of Al, 0.01 to 0.15 percent by mass of C, 0.001 to 0.03 percent by mass of B, the total amount of tungsten and molybdenum being 5.0 to 10 percent by mass.A welded turbine rotor is structured by joining or building up by welding a second Ni-base alloy to a first Ni-base alloy that a γ′ phase solid solution temperature thereof is 900° C. or higher and a creep fracture strength at 675° C. is 100 MPa or more, and further welding a ferritic steel to the second Ni-base alloy. The second Ni-base alloy is a γ′ phase (Ni3Al) precipitation strengthening type Ni-base alloy, a γ′ phase solid solution temperature thereof is 850° C. or lower. |
| US08883070B2 |
Molten metal containment structure having flow through ventilation
Exemplary embodiments of the invention provide a molten metal containment structure including a refractory molten metal containment vessel having an external surface, and a metal casing for the vessel having an internal surface at least partially surrounding the external surface of the vessel at a distance therefrom forming a spacing between the vessel and the casing. The spacing includes an unobstructed upwardly extending gap that is vented to the exterior of the structure by upper and lower openings in the casing. A layer of insulating material is preferably positioned in the spacing between the internal surface of the casing and the external surface of the vessel, with the layer of insulating material being narrower than the spacing at least at upwardly extending sides of the casing, thereby forming the unobstructed gap. The vessel may be a metal conveying trough, a housing for a metal filter, a container for a metal degasser unit, a crucible, or the like. |
| US08883066B2 |
Porous membrane, process for producing porous membrane, process for producing clarified liquid, and porous-membrane module
A porous membrane with the membrane wall constructed of a hydrophobic polymer and a hydrophilic polymer, wherein when the membrane wall is divided into 3 sections in the film thickness direction to form region “a” containing one wall surface A of the membrane wall, region “c” containing the other wall surface C and region “b” between region “a” and region “c”, the hydrophilic polymer content ratio Ca in region “a” is greater than the hydrophilic polymer content ratio Cc in region “c”, and the mean pore size of the wall surface C is larger than the mean pore size of the wall surface A. |
| US08883062B2 |
Multi-layered golf balls having a thin outer cover
Multi-layered golf balls having an inner core, at least one intermediate layer, and outer cover are provided. The outer cover is made from am ultra-low melt index (ULMI) thermoplastic material using an in-molding coating process that involves applying a thin layer of the material to the interior surface of the cover mold members. Preferably, the ultra-low melt index material is a highly neutralized ionomer ethylene-based copolymer. The cover layers made from these highly neutralized polymers (HNPs) are thin and uniform and provide the golf ball with good playing performance properties. Yet, the cover layers also are tough and provide the golf ball with good impact durability. |
| US08883056B2 |
Method for preparing cellulose-based film and cellulose-based film
Disclosed herein is a method for preparing a cellulose-based film from raw material pulp, the method including the steps of: preparing a dope from a composition comprising 5-15 wt % of a pulp having an alpha-cellulose content of more than 90% and 85-95 wt % of an aqueous N-methylmorpholine-N-oxide solution; extruding the dope from a die onto a running support; casting the extrudate to form a sheet-shaped material; washing the cast sheet with water to remove N-methylmorpholine-N-oxide therefrom; and drying the washed sheet. The method enables the cellulose-based film to be prepared from environmentally friendly wood pulp through an environmentally friendly process. |
| US08883051B2 |
Methods for increasing the ion permeability of contact lenses
Described herein are methods for increasing the ion permeability of a silicone hydrogel contact lens by adding a small amount of an ion-permeability-enhancing (“IP-enhancing”) hydrophilic vinylic monomer or macromer into a lens-forming material for cast-molding silicone hydrogel contact lenses, while not altering significantly the water content and/or the oxygen permeability of resultant lenses from the lens-forming material. |
| US08883048B2 |
Reflector for light-emitting device, and light-emitting device
The present invention relates to a reflector for a light-emitting device consisting of (A) an polyamide composition comprising a polyamide polymerized from (a) a dicarboxylic acid comprising at least 50 mol % of an alicyclic dicarboxylic acid and (b) a diamine comprising at least 50 mol % of a diamine with a branched main chain. |
| US08883037B2 |
Chiral compounds, cholesteric and ferroelectric liquid crystal compositions comprising these chiral compounds, and liquid crystal displays comprising these liquid crystal compositions
Chiral liquid crystal compounds of the general formula (1): in which at least one of R1 and R2 is a chiral substituent, K may be a single bond or the same as K1-5 and K1-5 denote a six-membered ring system which rings may be at least partially unsaturated, wherein the number of atoms in these rings or ring systems between the two atoms forming a part of the link to the next ring, or to one of the substituents R1 and R2, does not differ by more than one if counted in the clockwise, and in the counter-clockwise sense, starting from the same atom in each case, X1-20 denote alkyl, or alkoxy, or fluorinated alkyl, or fluorinated alkoxy groups, or atom H, or halogen atoms, mixtures comprising such chiral liquid crystal compounds, and liquid crystal displays comprising such mixtures as active ingredients. |
| US08883033B2 |
Method for removing nitride material
A method for removing silicon nitride material includes following steps. A substrate having at least a gate structure formed thereon is provided, and at least a silicon nitride hard mask is formed on top of the gate structure. A first removal is performed to remove a portion of the silicon nitride hard mask with a first phosphoric acid (H3PO4) solution. A second removal is subsequently performed to remove remnant silicon nitride hard mask with a second phosphoric acid solution. The first removal and the second removal are performed in-situ. A temperature of the second phosphoric acid solution is lower than a temperature of the first phosphoric acid solution. |
| US08883032B2 |
Method of surface treatment for zirconia dental implants
A method of surface treatment for zirconium oxide implants and the etching formula for the same are disclosed. The processes are carried out at room temperature. The average surface roughness Ra and the standard deviation of the implant are measured showing significant improvement while comparing with the un-treated sample and the hydrofluoric acid treated samples. The average contact angle is provided showing an almost hydrophilic surface after etched by the formula according to the present invention. |
| US08883031B2 |
CMP polishing liquid and polishing method
The CMP polishing liquid containing a medium and silica particles as an abrasive grain dispersed into the medium. The silica particles have a silanol group density of 5.0/nm2 or less and the biaxial average primary particle diameter when arbitrary 20 silica particles are selected from an image obtained by scanning electron microscope observation is 25 to 55 nm. The association degree of the silica particles is 1.1 or more. The CMP polishing liquid has the high barrier film polishing speed, the favorable abrasive grain dispersion stability, and the high interlayer dielectric polishing speed. The CMP polishing liquid can provide a method of producing semiconductor substrates or the like, that have excellent microfabrication, thin film formation, dimension accuracy, electric property and high reliability with low cost. |
| US08883028B2 |
Mixed mode pulsing etching in plasma processing systems
A method for processing substrate in a chamber, which has at least one plasma generating source, a reactive gas source for providing reactive gas into the interior region of the chamber, and a non-reactive gas source for providing non-reactive gas into the interior region, is provided. The method includes performing a mixed-mode pulsing (MMP) preparation phase, including flowing reactive gas into the interior region and forming a first plasma to process the substrate that is disposed on a work piece holder. The method further includes performing a MMP reactive phase, including flowing at least non-reactive gas into the interior region, and forming a second plasma to process the substrate, the second plasma is formed with a reactive gas flow during the MMP reactive phase that is less than a reactive gas flow during the MMP preparation phase. Perform the method steps a plurality of times. |
| US08883024B2 |
Using vacuum ultra-violet (VUV) data in radio frequency (RF) sources
The invention provide apparatus and methods for creating gate structures on a substrate in real-time using Vacuum Ultra-Violet (VUV) data and Electron Energy Distribution Function (EEDƒ) data and associated (VUV/EEDƒ)-related procedures in (VUV/EEDƒ) etch systems. The (VUV/EEDƒ)-related procedures can include multi-layer-multi-step processing sequences and (VUV/EEDƒ)-related models that can include Multi-Input/Multi-Output (MIMO) models. |
| US08883017B1 |
Method and system for providing a read transducer having seamless interfaces
A method and system provide a substantially seamless interface in a magnetic transducer. The magnetic recording transducer includes a first layer and a second layer on the first layer. The second layer is different from the first layer. The first layer consists of at least one material. The method includes removing at least the second layer using a first removal process. A residue of the second layer and a first portion of the first layer remain after the first removal process. A first sacrificial layer consists of the at least one material on the first portion of the first layer. At least the first sacrificial layer is removed using a second removal process. A second portion of the first layer remains after completion of the second removal process. An additional structure is provided. The seamless interface is between the second portion of the first layer and the additional structure. |
| US08883016B2 |
Carrier for manufacturing printed circuit board, method of manufacturing the same and method of manufacturing printed circuit board using the same
Disclosed is a carrier for manufacturing a printed circuit board, which includes a first carrier including a first binder having a first opening and a first metal layer formed in the first opening of the first binder, and a second carrier, stacked with the first carrier and including a second binder having a second opening and a second metal layer which is formed in the second opening of the second binder and which partially overlaps with the first metal layer, so that the carrier is simply configured and the binders are formed not only on the lateral surfaces of the metal layers but also on the upper surfaces thereof, thus improving the reliability of bonding of the carrier at the periphery. A method of manufacturing the carrier and a method of manufacturing a printed circuit board using the carrier are also provided. |
| US08883013B2 |
Facility for treating an aqueous fluid by contact with a fluidised bed of coagulated activated carbon in powder form
The present invention relates to a treatment installation of aqueous fluid, in particular to ensure elimination of organic micropollutants and natural organic matter, comprising a single reactor (10) for treatment of aqueous fluid by contact with a fluidized bed of coagulated and flocculated powdered activated carbon, operating in ascending flow, said reactor being equipped with injection means of new powdered activated carbon, coagulant and polymer, arranged to define three distinct operating zones in the reactor: a first arranged zone (A) at the base of the reactor to ensure intake and homogeneous distribution of the aqueous fluid pre-treated by contact with coagulant and polymer, a second zone, surmounting the first, constituted by the fluidized bed of coagulated and flocculated powdered activated carbon (B), and a third zone (C), arranged in the top part of the reactor for separation and recovery of the purified aqueous liquid. |
| US08883005B2 |
Portable water treatment device
The present invention is uniquely engineered and provides water treatment devices for treatment of water in a small community or individual who are out of reach of access to safe water for domestic use, reach of adequate resources and reside in rural setting. Water treatment device of the invention are flexible, light weight and have high capacity. |
| US08883001B2 |
Separating agent for optical isomers and separation column for optical isomers
This invention provides a separating agent for optical isomers, which has high asymmetry recognition ability and can be used particularly at a high flow rate when used for the separation of the optical isomers, and a separation column for optical isomers having the same. This invention provides: a separating agent for optical isomers which is used for separation of optical isomers in a sample comprising the optical isomers, which is comprising a monolithic inorganic type carrier having a meso pore formed on an inner wall surface of a specific macropore, and a polysaccharide or a polysaccharide derivative supported on the monolithic inorganic type carrier, wherein the meso pore has a pore size of 6 to 100 nm; and a separation column for optical isomers in which the separating agent for optical isomers is held in a column tube. |
| US08882998B2 |
Device for dispensing a volatile substance
The present invention relates to the field of perfumery and more precisely it concerns a device, and the consumer articles associated therewith, for dispensing an active composition into the surrounding space. The device includes an assembly containing a reservoir holding the active liquid to be diffused into the surroundings and a wick-/emitting member structure composed of a wick member and an emitting/diffusion member, the latter having an evaporative surface to be directly exposed to the surrounding space when the device is activated, the assembly being housed in a casing or carried by a supporting frame, the device further including a pivoting member fixed on the casing or on the supporting frame to allow a swinging motion of the assembly and thus forced evaporation of the active volatile whenever desired. |
| US08882996B2 |
Micro-structure-based adhesives for size-selective particle trapping and sorting
A method of separating particles is provided that includes exposing a selective PDMS adhesive to a particle-contaminated surface, where the selective PDMS adhesive captures particles present on the particle-contaminated surface to form a fouled selective PDMS adhesive, and exposing the fouled selective PDMS adhesive to a PDMS transfer sheet, where particles outside of a desired range are transferred over to the PDMS transfer sheet, where the fouled selective PDMS adhesive retains only the particles of a desired range. |
| US08882992B2 |
Multi-stage reforming process to produce high octane gasoline
The present invention relates to a multistage reforming process to produce a high octane product. A naphtha boiling range feedstock is processed in a multi-stage reforming process, in which the process involves at least 1) a penultimate stage for reforming the naphtha feedstock to produce a penultimate effluent 2) a final stage for further reforming at least a portion of the penultimate effluent 3) a regeneration step for the final stage catalyst. The severity of the penultimate stage can be increased during final stage catalyst regeneration in order to maintain the target RON of the reformate product and avoid reactor downtime. |
| US08882991B2 |
Process and apparatus for cracking high boiling point hydrocarbon feedstock
In one aspect, the invention includes in a process for cracking a hydrocarbon feedstock comprising: a) feeding a hydrocarbon feedstock containing at least 1 wt % of resid components having boiling points of at least 500° C. to a furnace convection section to heat the feedstock; b) flashing the heated feedstock in a first flash separation vessel to create a first overhead stream and a first bottoms liquid stream; c) hydrogenating at least a portion of the first bottoms liquid stream to create a hydrogenated bottoms stream; d) flashing the hydrogenated bottoms stream in a second flash separation vessel to create a second overhead stream and a second bottoms liquid stream; e) cracking the first overhead stream and the second overhead stream in a cracking furnace to produce a pyrolysis effluent stream. In other embodiments, the process further comprises heating the hydrocarbon feedstock in step a) to a temperature within a range of from 315° C. to 705° C. |
| US08882990B2 |
Deoxygenation of fatty acids for preparation of hydrocarbons
Embodiments of methods for making renewable diesel by deoxygenating (decarboxylating/decarbonylating/dehydrating) fatty acids to produce hydrocarbons are disclosed. Fatty acids are exposed to a catalyst selected from a) Pt and MO3 on ZrO2 (M is W, Mo, or a combination thereof), or b) Pt/Ge or Pt/Sn on carbon, and the catalyst decarboxylates at least 10% of the fatty acids. In particular embodiments, the catalyst consists essentially of 0.7 wt % Pt and 12 wt % WO3, relative to a mass of catalyst, or the catalyst consists essentially of a) 5 wt % Pt and b) 0.5 wt % Ge or 0.5 wt % Sn, relative to a mass of catalyst. Deoxygenation is performed without added hydrogen and at less than 100 psi. Disclosed embodiments of the catalysts deoxygenate at least 10% of fatty acids in a fatty acid feed, and remain capable of deoxygenating fatty acids for at least 200 minutes to more than 350 hours. |
| US08882989B2 |
Lubricating base oil manufacturing plant for producing base oils having desired cycloparafinic functionality
A lubricating base oil manufacturing plant comprising a means for hydroisomerization dewaxing a wax at a specified hydrogen to feed ratio and a means for hydrofinishing the hydroisomerized wax to produce one or more base oils having greater than 10 weight percent total molecules with cycloparaffinic functionality and less than 0.5 weight percent molecules with multicycloparaffinic functionality. |
| US08882986B2 |
System and method for metal deburring
A system includes an electrolytic deburring tool, which includes a first electrode configured to be positioned at a first gap away from a first edge of a workpiece, a second electrode configured to be positioned at a second gap away from a second edge of the workpiece, a first electrolyte supply configured to flow a first electrolyte through the first gap between the first electrode and the first edge of the workpiece, a second electrolyte supply configured to flow a second electrolyte through the second gap between the second electrode and the second edge of the workpiece, and a power supply configured to flow an alternating current through the first gap and the second gap to cause electrolytic dissolution through the workpiece from both the first edge and the second edge. |
| US08882983B2 |
Embedded thin films
A method for forming a film on a conductive substrate, comprising immersing a substrate having a conductive portion in a solution comprising a metal ion ceramic precursor for the film and a peroxide; applying a voltage potential to the conductive portion with respect to a counter electrode in the solution, sufficient to protect the conductive portion from corrosion by the solution, and drive formation of a film on the substrate, controlling a pH of the solution while limiting a production of hydrogen by electrolysis of the solution proximate to the conductive portion; and maintaining the voltage potential for a sufficient duration to produce a film on the conductive portion. An electrode may be formed over the film to produce an electrical device. The film may be, for example, insulating, dielectric, resistive, semiconductive, magnetic, or ferromagnetic. |
| US08882981B2 |
Super-capacitor desalination devices and methods
A super-capacitor desalination device is described and includes a pair of terminal electrodes and at least one bipolar electrode located between the terminal electrodes. The at least one bipolar electrode has an ion exchange material disposed on opposing surfaces thereof The ion exchange material is a cation exchange material or an anion exchange material. A method for super-capacitor desalination is also provided. |
| US08882977B2 |
Microbiosensors based on DNA modified single-walled carbon nanotube and PT black nanocomposites
Glucose and ATP biosensors have important applications in diagnostics and research. Combining single-walled carbon nanotubes (SWCNTs) with Pt nanoparticles can significantly enhance the performance of electrochemical biosensors. This disclosure illustrates the use of single-stranded DNA (ssDNA) to modify SWCNTs to increase SWCNT solubility in water. Multiple embodiments with this configuration allows for exploration of new schemes of combining ssDNASWCNT and Pt black in aqueous media systems. These embodiments resulted in a nanocomposite with enhanced biosensor performance. The ssDNA-SWCNT/Pt black nanocomposite constructed by a layered scheme proved most effective in terms of biosensor activity. The key feature of this structure and method of use is the exploitation of ssDNASWCNTs as molecular templates for Pt black electrodeposition. Glucose and ATP microbiosensors fabricated utilizing this structure and method of use exhibited high sensitivity, wide linear range and low limit of detection. |
| US08882972B2 |
Support of ion exchange membranes
A support member for an improved three-chambered electrolytic cell is disclosed. A porous synthetic support system for exchange membranes in electrolytic cells is used for exchange membrane protection in electrolytic cells for the in situ generation of electrolysis solutions, such as bleach or hypochlorous acid. |
| US08882971B2 |
Sputtering apparatus and manufacturing method of semiconductor light-emitting element
A sputtering apparatus (1) includes: a chamber (10) having an inside maintained in a depressurized state to generate plasma discharge (20); a cathode (22) placed in the chamber (10) and holding a target (21); and a substrate holder (60) holding a substrate (110) so that one surface of the substrate (110) faces the surface of the target (21). The substrate (110) is arranged at an upper portion in the sputtering apparatus (1) with the surface of the substrate (110) facing downward. The target (21) is arranged at a lower portion in the sputtering apparatus (1) with the surface of the target (21) facing upward. The sputtering apparatus (1) includes a heater (65) for heating the substrate (110). The temperature of the substrate (110) is raised by absorbing electromagnetic waves radiated from the heater (65). A method of manufacturing a semiconductor light-emitting element using the sputtering apparatus is also disclosed. |
| US08882970B2 |
Apparatus and method for manufacturing carbon nanohorns
An apparatus for manufacturing carbon nanohorns includes a production chamber configured to irradiate a solid carbon material with a laser beam to produce a product containing carbon nanohorns; and a separation mechanism configured to separate the product produced in the production chamber into a lightweight component and a heavyweight component. The heavyweight component includes carbon nanohorn aggregate with high purity, and high-purity carbon nanotubes can be obtained by collecting the heavyweight component. |
| US08882965B2 |
Paper recycling system and paper recycling method
To provide a paper recycling device capable of recycling paper of increased whiteness level that can be widely used for applications other than paper for newspapers, the paper recycling device of the present invention has a dry type defibrator for crushing and defibrating paper, a first transport pipe for transporting defibrated material that was defibrated by the dry type defibrator, a cyclone for air classifying and deinking the defibrated material transported by the first transport pipe, a second transport pipe for transporting the defibrated material that was deinked by the cyclone, and a paper forming machine for forming paper with the defibrated material transported by the second transport pipe. |
| US08882964B2 |
Furnish pretreatment to improve paper strength aid performance in papermaking
The invention is directed towards methods, compositions, and apparatus for increasing the strength of paper made out of a furnish having a large proportion of OCC. The method involves the following steps: 1) Providing a paper furnish having a large amount of OCC in it, 2) adding strength promoter to the furnish prior to adding a strength agent to the furnish, 3) adding a strength agent to the furnish, and 4) making a paper product from the furnish. This method allows cheap OCC material to be used in a papermaking process without the quality problems that the anionic trash in OCC typically causes. Thus paper products having low costs and high quality can be produced. |
| US08882963B2 |
Processes to produce short cut microfibers
A process for producing a microfiber product stream is provided comprising:(A) contacting cut multicomponent fibers having a length of less than 25 millimeters with a heated aqueous stream in a fiber opening zone to remove a portion of the water dispersible sulfopolyester to produce an opened microfiber slurry; wherein the heated aqueous stream is at a temperature of at least 40° C.; and (B) routing the opened microfiber slurry to a primary solid liquid separation zone to produce the microfiber product stream and a first mother liquor stream; wherein the first mother liquor stream comprises water and the water dispersible sulfopolyester. |
| US08882951B2 |
Method for producing a tape product having diagnostic aids
A method for producing an analysis tape for fluid samples, in particular body fluids, is proposed. The method comprises providing a laminate tape having a laminate carrier tape and at least one diagnostic functional layer, and cutting the laminate tape in such a way that a diagnostic auxiliary label arises; transferring the diagnostic auxiliary label to a vacuum roller; and transferring the diagnostic auxiliary label to a carrier tape. In general, at least one vacuum roller is used for the transfer of the diagnostic auxiliary label to the carrier tape. The cutting of the diagnostic functional layer is effected in such a way that a free end of the diagnostic functional layer is lifted off from the laminate carrier tape by guiding the laminate carrier tape around a cutting edge with a small radius, wherein the diagnostic functional layer is cut at a predetermined distance from the lifted off free end by means of a cutting device. |
| US08882950B2 |
Prepreg winding method and apparatus
A prepreg winding method includes the steps of preparing a plate, a mandrel movable toward and away from the plate, and a press roll movable toward and away from the mandrel and having an axis parallel to the mandrel; mounting a prepreg on the plate, the prepreg being formed by impregnating reinforced fibers with a thermosetting resin sheet; winding a leading end of the prepreg mounted on the plate around the mandrel, and making a pressing force act on the plate and the mandrel therebetween with the prepreg sandwiched between the plate and the mandrel and making a pressing force act on the mandrel and the press roll therebetween with the prepreg sandwiched between the mandrel and the press roll; and winding the prepreg around the mandrel by rotating the mandrel and the press roll. |
| US08882947B2 |
Method and apparatus for manufacturing tyres for vehicle wheels
In a method of manufacturing tires for vehicle wheels, a green tire, once formed, is transferred into a vulcanization mold and pressed against the holding walls of a molding cavity. Concurrently with the pressing step, a fluid present between the green tire and the holding walls is evacuated through vent valves. The tire is brought into contact with the closing head of each valve so as to push it toward a closed position at which the closing head forms a contact seat spaced apart from the inner surface of the molding cavity in order to define an embedding recess between the inner surface of the molding cavity and the closing head. |
| US08882946B2 |
Ultrasonic sealing jaw and method for ultrasonic sealing
An ultrasonic sealing jaw (1) is used for sealing portions of plastic film to a tube so as to form a sealing engagement of the portions of plastic film around the circumference of the tube. The sealing jaw (1) includes a concave film-tube welding portion (7) for receiving the tube covered by the plastic films the film-tube welding portion (7) to form the film-tube attachment. Adjacent to at least one side of the film-tube welding portion (7) of the sealing jaw (1), is a substantially flat film-film welding portion (3, 4) for engaging the plastic film and sealing adjacent portions of plastic film to each other in an area adjoining the tube. A film-film welding portion (3, 4) defining a top plane (10) of the sealing jaw (1) has at least one recess with a surface (11) so as to form a cavity (12) and forms a cavity (12) with an opening towards the film-tube welding portion (7). |
| US08882944B2 |
Method for forming rustproof film on PC strand and PC strand
In a method for forming a rustproof film on a PC strand, the thickness of the resin film is set to 200±80 μm, the pre-heating is performed within a temperature range from 60 to 150° C. to prevent an occurrence of a cob-webbing phenomenon as a result of melting of the synthetic resin powder coating material and the post-heating is performed within a range from 150 to 250° C. in order to uniformize the thickness of the coats adhered to the outer peripheral surfaces of the core wire and the surrounding wires, and the temperature of the pre-heating is set to be lower than the temperature of the post-heating, and the synthetic resin powder coating material including particles having diameters in a range from 0.1 to 250 μm is used, and the line speed in the series of steps is set to 5 to 10 m/min. |
| US08882943B2 |
System and method for the production of gypsum board using starch pellets
The present invention relates to a system and method for the production of gypsum board using starch pellets. In accordance with the present disclosure, the starch necessary for board formation is provided in the form of starch pellets. These pellets are mixed with a gypsum slurry in a mixer. The pellets are initially insoluble and do not dissolve. However, during subsequent drying stages, the pellets become soluble and dissolve into the gypsum phase. This both provides the desired starch component and also results in the formation of voids within the set gypsum. |
| US08882937B2 |
Steel material composition for producing piston rings and cylinder sleeves
The invention relates to a steel material composition, in particular for producing piston rings and cylinder sleeves, containing the following elements in the given fractions in relation to 100% by weight of the steel material: 0.03-2.0% by weight B, 0.5-1.2% by weight C, 70.1-97.3% by weight Fe, 0.1-3.0% by weight Mn and 2.0-10.0% by weight Si. Said composition can be produced by melting the starting materials and casting the melt in a pre-fabricated mold. |
| US08882929B2 |
Silverware/flatware or parts washer apparatus and method thereof
An apparatus and a method of washing (or pre-washing) silverware/flatware, or one or more other objects/parts is provided. The apparatus and method utilizes a fluid-push/pull system and method in which generally an entire volume of fluid is pushed or pulled through a cavity in which the silverware/flatware or other objects/parts are located. A cavity is filled with fluid, a mass of silverware or other parts is located within the cavity, generally an entire volume of fluid is pumped out of the cavity, and the pumped fluid is directed back into the cavity to create a generally continuous flow of generally an entire volume of fluid through the cavity. |
| US08882925B2 |
Method for scale removal during a lignocellulosic conversion process
A method for processing of a lignocellulosic feedstock is provided comprising exposing lignocellulosic feedstock to acid in a reactor to hydrolyze at least hemicellulose present in said lignocellulosic feedstock, wherein during said exposing, a scale deposit comprising lignin forms on the inner surface of said reactor; and treating the scale deposit with an alkali solution at a temperature between about 140° C. and about 250° C. so as to remove scale. Also provided is a method for reducing scale deposit that forms on process equipment during a stage of reacting a lignocellulosic feedstock with acid. |
| US08882924B2 |
Pretreatment of solid biomass material comprising cellulose with ionic liquid medium
A process for pretreating a solid, cellulose-containing biomass material which pretreatment comprises contacting the solid biomass material with an Ionic Liquid medium under sub-solvating conditions. The pretreatment results in an opening up of the texture of the solid biomass material, while no or a limited amount of biomass material is dissolved. The Ionic Liquid medium preferably is an inorganic molten salt hydrate. The pretreated biomass material can be as a feedstock in any process that benefits from the change in texture resulting from the pretreatment. |
| US08882921B2 |
Thin film deposition apparatus
A thin film deposition apparatus capable of forming a precise deposition pattern on a large substrate includes a deposition source; a first nozzle disposed at a side of the deposition source having a plurality of first slits; a second nozzle disposed opposite to the first nozzle having a plurality of second slits; and a second nozzle frame bound to the second nozzle so as to support the second nozzle. The second nozzle frame includes two first frame portions spaced apart from each other and disposed in a direction in which the plurality of second slits are arranged, and two second frame portions each connecting the two first frame portions to each other, wherein the second frame portions are curved in the direction in which the plurality of second slits are arranged, so as to form arches. |
| US08882920B2 |
Thin film deposition apparatus
A thin film deposition apparatus to form a fine pattern on a large substrate. The thin film deposition apparatus includes a deposition source, a first nozzle that is disposed at a side of the deposition source and includes a plurality of first slits, a second nozzle that is disposed opposite to the deposition source and includes a plurality of second slits, and a second nozzle reinforcement unit that is disposed on the second nozzle and crosses the second nozzle. |
| US08882919B2 |
Combinatorial non-contact wet processing
An apparatus and method for combinatorial non-contact wet processing of a liquid material may include a source of a liquid material, a first reaction cell, a second reaction cell, a first plurality of gas jets disposed within an interior of the first reaction cell, the first plurality of gas jets configured to atomize the liquid material transferred to the interior of the first reaction cell, a second plurality of gas jets disposed within an interior of the second reaction cell, the second plurality of gas jets configured to atomize the liquid material transferred to the interior of the second reaction cell, a first vacuum element disposed along a periphery of the first reaction cell, and a second vacuum element disposed along a periphery of the at least a second reaction cell. |
| US08882915B2 |
Film deposition apparatus, film deposition method, and computer readable storage medium
A rotation table on which a wafer is placed is rotated around a vertical axis in order to supply to an upper surface of the wafer a first reaction gas for allowing the first reaction gas to be adsorbed on the upper surface, an auxiliary gas that reacts with the first reaction gas to produce an intermediate product having reflowability, and a second reaction gas that is reacted with the intermediate product to produce a reaction product in this order; and the reaction product is heated by a heating lamp in order to densify the reaction product. |
| US08882914B2 |
Processing substrates using site-isolated processing
Substrate processing systems and methods are described for processing substrates having two or more regions. The processing includes one or more of molecular self-assembly and combinatorial processing. At least one of materials, processes, processing conditions, material application sequences, and process sequences is different for the processing in at least one region of the substrate relative to at least one other region of the substrate. Processing systems are described that include numerous processing modules. The modules include a site-isolated reactor (SIR) configured for one or more of molecular self-assembly and combinatorial processing of a substrate. |
| US08882912B2 |
Method and system for forming a silicon ingot using a low-grade silicon feedstock
Techniques for the formation of a silicon ingot using a low-grade silicon feedstock include forming within a crucible device a molten silicon from a low-grade silicon feedstock and performing a directional solidification of the molten silicon to form a silicon ingot within the crucible device. The directional solidification forms a generally solidified quantity of silicon and a generally molten quantity of silicon. The method and system include removing from the crucible device at least a portion of the generally molten quantity of silicon while retaining within the crucible device the generally solidified quantity of silicon. Controlling the directional solidification of the generally solidified quantity of silicon, while removing the more contaminated molten silicon, results in a silicon ingot possessing a generally higher grade of silicon than the low-grade silicon feedstock. |
| US08882910B2 |
AlGaN substrate and production method thereof
A substrate is formed of AlxGa1-xN, wherein 0 |
| US08882909B2 |
Method for producing virtual Ge substrates for III/V-integration on Si(001)
Relaxed germanium buffer layers can be grown economically on misoriented silicon wafers by low-energy plasma-enhanced chemical vapor deposition. In conjunction with thermal annealing and/or patterning, the buffer layers can serve as high-quality virtual substrates for the growth of crack-free GaAs layers suitable for high-efficiency solar cells, lasers and field effect transistors. |
| US08882907B2 |
Additive composition for mortars, cements and joint compounds and cementitious compositions made therefrom
An additive composition for mortars, exterior insulation finish systems, self-leveling compounds and joint compounds is disclosed. The additive composition contains a nitrogen-containing polymer and a reactive agent capable of forming a crosslinking reaction with the nitrogen-containing polymer. Small amounts of the additive composition contained in a product cannot only increase one or more properties of the product but can also minimize the use of redispersible polymers in the product. |
| US08882904B2 |
Pigment dispersions, their preparation, and dispersants
Branched polyetheramine polyols with a Hazen color number (determined according to DIN ISO 6271) in the range of from 100 to 600 (APHA), based on a polycondensation product of at least one trialkanolamine. |
| US08882902B2 |
Composite pigment and method for preparation thereof
The present invention relates to a composite pigment comprising a substrate, said substrate being at least in part covered by at least one layer comprising at least one solid organic UV filter. The composite pigment can be prepared by a method comprising a step of subjecting a substrate, at least one solid organic UV filter, and optionally at least one solid inorganic UV filter, at least one additional UV filter and/or at least one coloring pigment, to a mechanochemical fusion process such as a hybridizer process. The composite pigment can be advantageously used as a component for a cosmetic composition. |
| US08882901B2 |
Dispersion comprising hydrophobized silicon dioxide particles, and paint preparation
Aqueous dispersion comprising hydrophobized silicon dioxide particles, comprising a. 50%-80% by weight of water, b. 10%-30% by weight of hydrophobized silicon dioxide particles, c. 5%-15% by weight of at least one alcohol alkoxylate of the general formula R1O((CH2)mO)nH, where R1 is a branched or unbranched alkyl or alkenyl radical having 10-25 C atoms, m is 2 or 3 and n is 10-50, d. 0.5%-5% by weight of at least one amine and/or amino alcohol having a molecular weight of less than 500 and e. 0%-1% by weight of N-methylpyrrolidone, all figures for weight percentages being based on the dispersion. Paint formulation comprising the dispersion. |
| US08882896B2 |
Multi-directional outlet transition and hood
Post-combustion conditioning systems are described that include a flue gas conditioning device configured to condition an exhaust stream to produce a conditioned stream. First and second outlet ducts can be fluidly coupled to, and substantially supported by, the flue gas conditioning device. This advantageously can eliminate costly ductwork, reduce the space required, and reduce the pressure drop of the system. The first outlet duct can fluidly couple the flue gas conditioning device to an exhaust duct, such that the conditioned stream can flow from the first conditioning device via the first outlet duct. |
| US08882887B2 |
Process stream desulfurization
A method of reducing the concentration of at least one sulfur compound in a process stream and for recovering at least one sulfur compound from a process stream are provided. A process stream is delivered to a vessel, wherein the vessel comprises an adsorbent material. At least one solvent is transferred into the vessel. One or more fluids are then removed from the vessel. At least one of the fluids removed from the vessel comprises a clean gas. The adsorbent material may be regenerated to yield a high concentration of the at least one sulfur compound. |
| US08882886B2 |
Aircraft fuel tank flammability reduction methods and systems and air separation methods using membranes
An aircraft fuel tank flammability reduction method includes contacting a membrane filter with air feed, permeating oxygen and nitrogen from the air feed through the membrane, and producing filtered air from the filter. The filtered air is produced from the filter as a result of the membrane removing any hydrocarbons containing six or more carbon atoms to produce a total of 0.001 ppm w/w or less. An air separation method includes feeding air into a filter containing a hollow fiber membrane that exhibits the property of resisting degradation due to exposure to hydrocarbons containing six or more carbon atoms. The filter exhibits a pressure drop across the membrane of less than 5 psi. The method includes feeding the filtered air into an air separation module containing a hollow fiber membrane that exhibits a susceptibility to degradation from exposure to hydrocarbons containing six or more carbon atoms. |
| US08882877B2 |
Boron-containing synergistic urea and preparation method and application thereof
The present invention provides a boron-containing synergistic urea and preparation method and application thereof, the boron-containing synergistic urea is a product obtained by mixing, dehydrating and pelletizing a mixed aqueous solution of polyaspartic acid chelated potassium (also referred to as “polypeptide chelated potassium”) and a borate amine salt together with molten urea, wherein the above three components are 0.04-0.12%, 0.08-0.24% and 99.64-99.88% by weight, respectively. The boron-containing synergistic urea provided by the present invention is obtained by effectively compositing polypeptide acid chelated potassium, borate amine salt and urea, which also can guarantee the application amount of effective boron, and meanwhile can help avoid excessive high local concentrations of boron, and achieve the purposes of prompting effective absorption of the plant to boron and of improving urea utilization rate. |
| US08882874B1 |
Flexible, multi-cartridge, reconfigurable/selectable air contaminant control system and method for fuel cells
A unique, multi-cartridge, easily re-configurable ambient air filter assembly (air contaminant control system) that removes particulate and gaseous chemical/biological contaminants from the incoming cathode air stream on a fuel cell or similar devices is described. The filter assembly is composed of individual filter cartridges (sub-assemblies) of various filtration media that are targeted at removing specific airborne contaminants. Combining specific sets of cartridges enables the filter assembly to be readily/rapidly configured (and re-configured) for specific applications—such as urban, rural, industrial, or military battlefield environments. Selection of correct media ensures complete removal of potential contaminants, enables rapid re-configuration to different environments, quick replacement of spent cartridges without disposal of non-spent media (reducing waste and cost). The invention concept is highly configurable to various sizes and shape fuel cells or other applications requiring clean ambient air by simply scaling the filter assembly size and air flow rates. |
| US08882863B2 |
Fuel reformulation systems
A fuel reformulation system for an engine comprising an annular body for a flow of fluids therethrough connected to the engine, a source of fuel for flowing through at least a portion of the annular body, and a catalytic member connected to the annular body for the flow of any fluids thereacross from the annular body. |
| US08882862B2 |
Method of forming a mesophase pitch from a coal extract suitable for processing to a high value coke
The present disclosure provides methods and systems for coal liquefaction and obtaining a mesophase pitch. A method of obtaining a quinoline insoluble-free and ash-free mesophase pitch may include exposing a coal to a hydrogenated vegetable oil in the presence of a coal-derived solvent to form a slurry, elevating the temperature of the slurry to facilitate liquefying the coal and liberating a volatile matter, separating the insoluble components from the slurry to obtain a de-ashed coal extract that is quinoline insoluble-free, and distilling the coal extract under vacuum to obtain a mesophase pitch with a softening point in the range of 25 degrees Celsius to 160 degrees Celsius, wherein the mesophase pitch can be coked to obtain an anisotropic coke. A quinoline insoluble-free and ash-free pitch may be obtained by the method. |
| US08882861B2 |
Oleaginous compounds from biomass
Disclosed herein are methods and processes for the recovery of oleaginous compounds from biomass and in particular biomass comprises photosynthetic microorganisms. Also disclosure are oleaginous compounds obtained using the disclosed methods. |
| US08882859B2 |
Method for manufacturing metal separator for fuel cell
A method of manufacturing a metal separator for a fuel cell includes molding two plates such that each plate has a least one concave portion and at least one convex portion, applying a sealant to a sealing portion of at least one of the plates, arranging the plates such that the concave portions of each plate are opposite the convex portions of the other plate, and spot welding the plates together. The sealing portion may be near an edge of the separator, between a hydrogen manifold, an oxygen manifold, and a coolant manifold. A sealant leakage prevention groove may further be provided at the sealing portion. The sealing portion may be made by being inserted between a projection on a first mold and a recess on a second mold, and a spot welding gun may be inserted through a guide hole in one of the molds. |
| US08882858B2 |
Apparatus and method for the production of electric energy storage devices
Production apparatus and method for producing devices for storing electric energy are disclosed, wherein stacks of flat cathodes and anodes that face one another alternately with the interposition of a separator are produced, and in which the separator is formed by a single continuous strip folded several times in a single folding direction. |
| US08882856B2 |
Process for producing electrolytic capacitors with a polymeric outer layer
The invention relates to a process for producing electrolytic capacitors with low equivalent series resistance, low residual current and high thermal stability, which consist of a solid electrolyte and an outer layer comprising conjugated polymers, to electrolytic capacitors produced by this process and to the use of such electrolytic capacitors. |
| US08882855B2 |
Gel-based oxidation colorant including an emulsifier combination and thickener
The present specification provides for an agent for dyeing keratinic fibers. The agent includes, in a gel-like carrier at least one oxidation dye precursor. The gel-like carrier includes at least one emulsifier combination. The emulsifier combination includes one or more non-ionic polyethoxylated emulsifiers selected from ethoxylated fatty alcohols containing between 8 and 22 carbon atoms, ethoxylated castor oil, or combinations thereof, and one or more polyethylene glycols having an average molecular weight between 100 and 100,000 grams per mole (g-MOL−1). The gel-like carrier also includes at least one polymeric thickener selected from homopolymers of acrylic acid or methacrylic acid, copolymers of acrylic acid or methacrylic acid with C1-C4 alkyl esters of acrylic acid or methacrylic acid, or combinations thereof. |
| US08882854B2 |
Reduction of ammonia odor when coloring and/or lightening hair
Agents and methods are provided for coloring and/or lightening keratinic fibers. In one embodiment, an agent for coloring and/or lightening keratinic fibers includes, in a cosmetic carrier, (a) one or more oxidation dye precursors, (b) ammonia, (c) one or more ethoxylated fatty alcohols having a degree of ethoxylation from 80 to 120, and (d) one or more zwitterionic polymers. The agent contains no carbonates. |
| US08882851B2 |
Implantable prosthetic device for distribution of weight on amputated limb and method of use with an external prosthetic device
Embodiments of the invention include an implantable force distribution boot with hydraulic features that mimic the natural hydraulics of a joint. Further embodiments include an exterior prosthetic leg device having intermittent and/or variable electromagnetic features that can engage with magnetic blades on the implantable force distribution boot. In use, the exterior prosthetic leg can be maintained on a residual limb by magnetic force between the implanted blades and the exterior electromagnets. Also disclosed are surgical techniques for preparing a residual limb to better receive and adapt to a prosthetic device. The techniques include an improved surgical method for harvesting a vascularized glabrous skin free flap. |
| US08882849B2 |
Acetabular cup with high retention capacity
An acetabular cup includes an articular insert (1) having a substantially semi-spherical articular cavity (1c), and a spherical head (2) engaged in the articular cavity (1c). A retaining device (10a) opposes the axial release (4) of the spherical head (2) from the articular cavity (1c) of the articular insert (1). For example, the retaining device can take the form of a back-tapered segment (10a) of the articular insert (1). The spherical head (2) is factory mounted in the articular insert (1), by temporarily heating the articular insert (1) and performing sterilization after assembly. In this way, the spherical head (2) retention capacity in the articular insert (1) is increased substantially in order to reduce the risk of luxation. |
| US08882844B2 |
Intervertebral instrument, implant, and method
An intervertebral instrument includes a shaft having distal and proximal ends. The proximal end of the shaft includes an attaching feature connected to handle. The shaft defines a pair tracks disposed along a portion of the surface thereof. The distal end includes a pair of wings. Each track guides instruments and implants along the intervertebral instrument. The implants are configured to receive bone graft or bone enhancers. The distal end of the shaft may include a removably attachable tip configured to engage the implants. The implants and the removably attachable tip form an implantable intervertebral disk. An intervertebral instrument and implant kit is also disclosed. A method of inserting intervertebral implants is also disclosed. |
| US08882839B2 |
Intervertebral implant
In an intervertebral implant, having an upper part that has a support face for a vertebra and a lower part that has a support face for an adjacent vertebra, on each of which parts engagement elements, which are accessible from one side of the intervertebral implant, for a manipulation instrument are disposed, in order to minimize the structural height of the intervertebral implant upon insertion into an intervertebral space, it is proposed that the upper part and lower part each have protrusions and recesses aimed at the respectively other part, which are offset laterally from one another in such a way that when the upper part has been brought close to the lower part they mesh with one another; and that the engagement elements on the upper part and on the lower part are each disposed in protrusions of these parts in such a way that the engagement elements of the upper part and lower part are located side by side and at least partly overlap in the direction of the height of the intervertebral implant. |
| US08882836B2 |
Apparatus and method for treating bone
A bone tamp for creating channels within bone tissue. The bone tamp includes an elongated member that is deformable from a first generally non-linear configuration to a second generally linear configuration for insertion into bone tissue. As the elongated member is deployed into bone tissue, it transitions from the linear configuration into the non-linear configuration within the bone tissue. The elongated member is capable of being deformed back into the generally linear configuration for withdrawal from the bone tissue. |
| US08882834B2 |
Soft tissue repair
Methods and instruments for repairing soft tissues of a skeletal joint, such as, for example, of the foot or hand are presented. The method includes the steps of maintaining the metapodial bone intact; forming a bone tunnel through the proximal phalanx between volar and dorsal aspects of the proximal phalanx; passing a repair suture through the soft tissue to be repaired; passing the repair suture through the bone tunnel; and securing the suture. The method may be used for the repair of soft tissue, such as a volar ligament and/or a collateral ligament. |
| US08882833B2 |
Drill pin for fixation of ligaments using button/loop construct
A technique and reconstruction system for ligament employing a button/loop construct with a drill pin. The drill pin has a shaft with a proximal and a distal end. A pin tip provided at the distal end of the shaft has a width greater than the shaft diameter. The pin tip helps cut a wider tunnel for fixation of ligaments/grafts in reconstructive surgeries. The shaft of the drill pin is provided with a laser marks for measurement of intraosseous length. |
| US08882832B2 |
Implantable prosthesis
The invention relates to an implantable prosthesis and a shell for an implantable prosthesis and methods for making them, in particular a light weight implantable prosthesis containing a biocompatible filler which is suitable for use as a breast implant. |
| US08882824B2 |
Expanding vascular stent
An expanding vascular stent is disclosed that is inserted into a blood vessel in the human body and expands the blood vessel. The stent is configured in such a way that adjacent rows, each of which is comprised of a plurality of identical cells, are symmetrically arranged, in an out of phase manner. When the stent is expanded in the radial direction, the adjacent rows are expanded in opposite directions, maintaining their linearly symmetrical state. Therefore, the reduction in the length of the stent can be minimized. Since the stent has also a great degree of flexibility, when it is inserted into the blood vessel, it can minimize the damage to the blood vessel wall. |
| US08882822B2 |
Non-thrombogenic stent jacket
Disclosed is the use of serous tissue, such as pericardium, as a component of intracorporeal implants. Particularly, disclosed is a jacketed stent assembly comprising an expandable stent provided with a jacket of processed serous tissue which, in some embodiments, is impregnated with a therapeutic or diagnostic agent. In a preferred embodiment, the jacket of the expandable stent is formed of pericardial tissue, preferably bovine or porcine pericardial tissue. |
| US08882820B2 |
Inflatable convective pad for surgery
An inflatable convective pad for warming a person during surgery has two ends, two sides, and at least two openings, each located in an area of the pad between the two ends and between a respective side and the center of the pad. The openings, which may be in the form of slits, allow the threading of a sheet or the person's arms through the pad to restrain the arms during surgery. |
| US08882818B1 |
Method for deploying a fusion device for sacroiliac joint fusion
A method for fusing a spinal sacroiliac joint and a surgical kit. The kit includes a bone-void filler, stabilization device or implant, a guide pin, a joint locator, a set of dilation tubes, a reamer, a novel directional cannula, a novel tapping cap, a novel drill guide, a drill bit, and a novel implant positioner. The method includes the steps of locating the sacroiliac joint, retracting the soft tissue exposing the graft site, removing any bone obstructions and preparing a relatively smooth graft site horizontal to the immediate sacroiliac joint, creating a cavity in the ilium and sacrum to a predetermined depth that spans the sacroiliac joint, inserting a novel stabilization implant into the cavity, and seating the implant within the cavity at a predetermined depth. |
| US08882816B2 |
Fixation and alignment device and method used in orthopaedic surgery
Surgical anchoring systems and methods are employed for the correction of bone deformities. The anchoring system and its associated instrument may be suitable for surgical repair of hallux valgus, tarsometatarsal sprains, ankle ligament reconstruction, spring ligament repair, knee ligament reinforcement, acromioclavicular sprains, coracoclavicular sprains, elbow ligament repair, wrist and hand ligamentous stabilization or similar conditions. The anchoring system may include a fixation system for anchoring two or more sections of bone or other body parts and a system for aligning of one section relative to another section. |
| US08882815B2 |
Flexible plate fixation of bone fractures
Embodiments provide methods, apparatuses, and systems for fixation of a fractured bone. In various embodiments, the systems and plates may provide elastic suspension of the receiving holes relative to the osteosynthesis plate. This elastic suspension may promote load distribution between the screws that connect a bone segment to the plate, thereby reducing stress risers and load shielding effect. In addition, stress at the screw holes, and within the construct as a whole, is reduced by incorporation of these elastic elements in the plate. Additionally, in some embodiments, for instance if fracture healing by callus formation is desired, elastic suspension of the receiving holes relative to the osteosynthesis plate may enable small, controlled amounts of relative motion between bone fragments connected by the plate, which may promote fracture healing by callus formation. |
| US08882813B2 |
Locking mechanisms and associated methods
A method and apparatus is provided for use with a surgical implant to secure fasteners, such as bone screws or pins. An anti-backout mechanism is used to preventing migration of the fasteners after the implant is installed. In one example, an anti-backout mechanism includes a locking plate having a locked position and an unlocked position. The locking plate has one or more protrusions that are configured to prevent migration the fasteners when the locking plate is in the locked position. |
| US08882811B1 |
Spinal implant system and method
A method for treating a spine includes creating a single minimally invasive incision in tissue; manipulating a lateral portion without manipulating a contralateral portion of the tissue to deliver fasteners and a rod through the incision, the fasteners being delivered along cortical trajectories disposed in alignment with vertebral levels; fastening the fasteners with the vertebral levels adjacent the lateral portion; connecting the rod with the fasteners; manipulating the contralateral portion without manipulating the lateral portion to deliver fasteners and a rod through the incision, the fasteners being delivered along cortical trajectories disposed in alignment with the vertebral levels; fastening the fasteners with the vertebral levels adjacent the contralateral portion; and connecting the rod with the fasteners. Systems and implants are disclosed. |
| US08882808B2 |
Spinal implant
This disclosure relates to a spinal implant that can provisionally retain a rod in an assembly head without having to first lock the rod relative to the assembly head. The spinal implant has a clip insert structured to retain the rod in the assembly head. The clip insert has a top portion with a cylindrical opening and extending over the cylindrical opening to cover the connection rod in part when the connection rod is engaged in the clip insert. The top portion is deformable by application of force on the connection rod to engage the connection rod with the clip insert. The clip insert and the assembly head are mechanically decoupled and can be fully received within the assembly head. The mechanical forces to which the assembly head is subjected are not transmitted to the clip insert. |
| US08882807B2 |
Minimally invasive surgery pedicle screw system
The present invention provides a minimally invasive surgery pedicle screw system, including: a plurality of slotted guides that are selectively inserted through one or more surgical incisions; a plurality of pedicle screws selectively coupled to the plurality of slotted guides that are selectively secured to one or more bony anatomical structures; a pendulum mechanism selectively translatably and pivotably coupled to one of the plurality of slotted guides; and a connecting rod selectively translatably and pivotably coupled to one of the plurality of slotted guides; wherein the pendulum mechanism is selectively coupled to the connecting rod. The connecting rod is selectively secured to one or more of the plurality of pedicle screws. |
| US08882806B2 |
Spine stabilization system with self-cutting rod
A spine stabilization system is provided. The system utilizes a self-cutting rod having a sharp cutting edge that can be anchored to a patient's spine with pedicle screws. The system can be percutaneously delivered, low profile, and allow cutting of surrounding tissue rather than simply spreading the tissue apart during rod insertion. |
| US08882802B2 |
Chiropractic machine
A chiropractic machine is disclosed which uses separate supporting members for the various body parts of a patient. These separate supporting members are mounted on a flexible structure that allows them to be rotated and elongated in relation to each other. This allows greater flexibility and range of motion, thus facilitating chiropractic treatment. |
| US08882799B2 |
Medical instrument for grasping an object, in particular a needle holder
The present invention relates to a medical instrument for grasping an object, in particular a surgical needle holder, with two jaw parts arranged at a distal end of a shaft, at least one of the jaw parts being pivotable with respect to the other one of the jaw parts between a grasp state for grasping the object between the jaw parts and a release state for releasing the object, and with a latching mechanism comprising at least one latching element, wherein the latching element has an elongated opening to accommodate a connection pin for connecting the at least one pivotable jaw part with the latching element, and wherein the elongated opening is divided in several sections along its length by periodical projections, such that the at least one pivotable jaw part pivots stepwise from one stable latched position to another stable latched position. |
| US08882797B2 |
Methods of embolic filtering
Methods of providing embolic protection during treatment of a vessel include advancing a microcatheter in the vessel, inserting a textile structure in a collapsed state into the microcatheter, and advancing the textile structure through the microcatheter. The methods may include, after advancing the textile structure and retracting the microcatheter to unsheathe a self-expanding bulb of the textile structure from the microcatheter, thereby allowing the self-expanding bulb to self-expand from the collapsed state to an expanded state. The methods may include performing a vascular procedure. In the expanded state, the self-expanding bulb may filter emboli released during performing the vascular procedure. |
| US08882796B2 |
Three element coaxial vaso-occlusive device
A vaso-occlusive device includes inner, intermediate, and outer elements arranged coaxially. The inner element is a filamentous element, preferably a microcoil. The intermediate element is made of a non-metallic material, preferably an expansile polymer. The outer element is substantially non-expansile and defines at least one gap or opening through which the intermediate element is exposed. In a preferred embodiment, when the intermediate element is expanded, it protrudes through the at least one gap or opening in the outer element and assumes a configuration with an undulating, convexly-curved outer surface defining a chain of arcuate segments, each having a diameter significantly greater than the diameter of the outer element. The expanded configuration of the intermediate element minimizes friction when the device is deployed through a microcatheter, thereby reducing the likelihood of buckling while maintaining excellent flexibility. The result is a device with enhanced pushability and trackability when deployed through a microcatheter. |
| US08882795B2 |
Frontal sinus dilation catheter
A balloon dilation catheter includes a substantially rigid inner guide member and a movable shaft coupled to a balloon that is slidably mounted on the substantially rigid inner guide member. To treat a sinus cavity of a subject using the balloon dilation the substantially rigid inner guide member is advanced into a drainage pathway of the sinus (e.g., frontal recess) of the subject via a nasal passageway. The shaft and balloon are advanced in a distal direction over the substantially rigid inner guide member to place the balloon in the drainage pathway. The balloon is inflated to expand or otherwise remodel the drainage pathway. |
| US08882791B2 |
Ultrasonic surgical instruments
A surgical instrument includes a transducer configured to produce vibrations at a predetermined frequency. The transducer is configured to produce vibrations at a predetermined frequency. An ultrasonic blade extends along the longitudinal axis and is coupled to the transducer. The ultrasonic blade includes a body having a proximal end and a distal end. The distal end is movable relative to the longitudinal axis by the vibrations produced by the transducer. The body includes a treatment region that extends from the proximal end to the distal end. The body includes surface coatings to prevent the formation of a thin layer of fluid on the body which may be atomized thus creating a mist. The body may also include a bore configured to emit a spray which will also prevent the formation of thin layer of fluid on the body. |
| US08882790B2 |
Drug eluting sculpting balloon
A plaque-modifying balloon and method for use in an endovascular procedure includes an elongated balloon that defines a longitudinal axis and is inflatable from a first deflated configuration to a second radially expanded configuration. One or more plaque-modifying elements are mounted on the outside of the inflatable balloon. Optionally, a compressible sheath made of a relatively low durometer, flexible material is mounted on the balloon to cover the elements during transit of the plaque-modifying balloon to and from the treatment site. |
| US08882789B2 |
Methods and systems for tissue manipulation
Endoscopic treatment methods and systems for endoscopic treatment are provided. An endoluminal treatment device and method in an exemplary embodiment includes introducing an endoluminal device into a lumen of a patient and engaging a wall of the lumen with an implant device without creating an incision in the patient. The implant device can be a drug delivery device or medical device. |
| US08882787B2 |
Tissue anchor apparatus
A structure that can be used to provide an anchor in or adjacent to a patient's soft body tissue (rather than bone) includes an annular array of flexible members that extend between two axially spaced but aligned tubular members. The space between the tubular members can be selectively changed to affect the amount by which portions of the flexible members between the tubular member project radially outward relative to the tubular members. When the flexible members project radially out, the structure resists axial movement relative to adjacent tissue and therefore acts as an anchor. When the flexible members do not project radially out, they permit axial movement of the structure through adjacent tissue. |
| US08882784B2 |
Biological unit removal tools with concentric tubes
Tools and methods are provided for removing biological units from a body surface utilizing a removal tool. The tools may incorporate retention members and mechanisms configured to impede movement of the biological unit in the direction of a distal end of the tool and to improve retention of the biological unit in the tool. Some of the retention members are stationary and some are movable within the lumen of the biological unit removal tools. The distal tips of the tools are desirably configured to reduce the chance of transection of a biological unit, such as by including both cutting segments and blunt relief segments. A number of dual concentric tube embodiments permit a division of removal functions. Distal fluid or gas delivery may be used to help separating biological units from surrounding tissue. |
| US08882779B2 |
Total joint arthroplasty system
A method and system for performing a total joint arthroplasty procedure on a patient's damaged bone region. A CT image or other suitable image is formed of the damaged bone surfaces, and location coordinate values (xn,yn,zn) are determined for a selected sequence of bone surface locations using the CT image data. A mathematical model z=f(x,y) of a surface that accurately matches the bone surface coordinates at the selected bone spice locations, or matches surface normal vector components at selected bone surface locations, is determined. The model provides a production file from which a cutting jig and an implant device (optional), each patient-specific and having controllable alignment, are fabricated for the damaged bone by automated processing. At this point, the patient is cut open (once), the cutting jig and a cutting instrument are used to remove a selected portion of the bone and to provide an exposed planar surface, the implant device is optionally secured to and aligned with the remainder of the bone, and the patient's incision is promptly repaired. |