Document Document Title
US08546676B2 Pedal device for electronic percussion instrument
A pedal device for an electronic percussion instrument, including: a base; a foot board supported at its first end portion to the base and configured to pivot by depression; an arm rotatably supported at its first end at a pivot point located near to a second end portion of the foot board, the arm being pivotable about the pivot point; a mass portion provided near to a second end of the arm; a regulating portion for regulating a locus of displacement of the mass portion when the foot board is moved from a depression start position to a depression end position; and a stopper portion provided on the base for defining the depression end position by contacting the mass portion in a forward stroke of depression, the regulating portion regulating the locus of the displacement of the mass portion so as not to contain a downward component in the forward stroke.
US08546675B1 Synthesized string tuner
A method for tuning a musical instrument comprising: (a) digitizing the vibration of at least one vibrating element of the instrument; (b) estimating the fundamental frequency of the vibration; and (c) conditioned upon at least the estimated frequency, generate an audio signal that comprises the characteristics of the original vibration signal with a different fundamental frequency.
US08546672B1 Apparatus for playing a stringed instrument
Disclosed are various embodiments for an apparatus for playing a stringed instrument that has a surface facing multiple strings. The apparatus includes an input device and a carriage assembly having multiple picks configured to sound strings of the stringed instrument. In response to data received from the input device, the picks are configured to move across the strings from a first position, with the strings between the picks and the surface of the stringed instrument, to a second position, with the picks between the strings and the surface of the stringed instrument.
US08546669B1 Maize variety hybrid X08B800
A novel maize variety designated X08B800 and seed, plants and plant parts thereof, produced by crossing Pioneer Hi-Bred International, Inc. proprietary inbred maize varieties. Methods for producing a maize plant that comprises crossing hybrid maize variety X08B800 with another maize plant. Methods for producing a maize plant containing in its genetic material one or more traits introgressed into X08B800 through backcross conversion and/or transformation, and to the maize seed, plant and plant part produced thereby. This invention relates to the maize variety X08B800, the seed, the plant produced from the seed, and variants, mutants, and minor modifications of maize variety X08B800. This invention further relates to methods for producing maize varieties derived from maize variety X08B800.
US08546666B1 Maize variety hybrid X85A670
A novel maize variety designated X85A670 and seed, plants and plant parts thereof, produced by crossing Pioneer Hi-Bred International, Inc. proprietary inbred maize varieties. Methods for producing a maize plant that comprises crossing hybrid maize variety X85A670 with another maize plant. Methods for producing a maize plant containing in its genetic material one or more traits introgressed into X85A670 through backcross conversion and/or transformation, and to the maize seed, plant and plant part produced thereby. This invention relates to the maize variety X85A670, the seed, the plant produced from the seed, and variants, mutants, and minor modifications of maize variety X85A670. This invention further relates to methods for producing maize varieties derived from maize variety X85A670.
US08546664B1 Maize variety hybrid X90B041
A novel maize variety designated X90B041 and seed, plants and plant parts thereof, produced by crossing Pioneer Hi-Bred International, Inc. proprietary inbred maize varieties. Methods for producing a maize plant that comprises crossing hybrid maize variety X90B041 with another maize plant. Methods for producing a maize plant containing in its genetic material one or more traits introgressed into X90B041 through backcross conversion and/or transformation, and to the maize seed, plant and plant part produced thereby. This invention relates to the maize variety X90B041, the seed, the plant produced from the seed, and variants, mutants, and minor modifications of maize variety X90B041. This invention further relates to methods for producing maize varieties derived from maize variety X90B041.
US08546663B2 Plants and seeds of hybrid corn variety CH232367
According to the invention, there is provided seed and plants of the hybrid corn variety designated CH232367. The invention thus relates to the plants, seeds and tissue cultures of the variety CH232367, and to methods for producing a corn plant produced by crossing a corn plant of variety CH232367 with itself or with another corn plant, such as a plant of another variety. The invention further relates to genetic complements of plants of variety CH232367.
US08546657B2 Soybean variety XB25Q11
A novel soybean variety, designated XB25Q11 is provided. Also provided are the seeds of soybean variety XB25Q11, cells from soybean variety XB25Q11, plants of soybean XB25Q11, and plant parts of soybean variety XB25Q11. Methods provided include producing a soybean plant by crossing soybean variety XB25Q11 with another soybean plant, methods for introgressing a transgenic trait, a mutant trait, and/or a native trait into soybean variety XB25Q11, methods for producing other soybean varieties or plant parts derived from soybean variety XB25Q11, and methods of characterizing soybean variety XB25Q11. Soybean seed, cells, plants, germplasm, breeding lines, varieties, and plant parts produced by these methods and/or derived from soybean variety XB25Q11 are further provided.
US08546655B2 Soybean variety XB25X11
A novel soybean variety, designated XB25X11 is provided. Also provided are the seeds of soybean variety XB25X11, cells from soybean variety XB25X11, plants of soybean XB25X11, and plant parts of soybean variety XB25X11. Methods provided include producing a soybean plant by crossing soybean variety XB25X11 with another soybean plant, methods for introgressing a transgenic trait, a mutant trait, and/or a native trait into soybean variety XB25X11, methods for producing other soybean varieties or plant parts derived from soybean variety XB25X11, and methods of characterizing soybean variety XB25X11. Soybean seed, cells, plants, germplasm, breeding lines, varieties, and plant parts produced by these methods and/or derived from soybean variety XB25X11 are further provided.
US08546653B2 Soybean cultivar S090130
A soybean cultivar designated S090130 is disclosed. The invention relates to the seeds of soybean cultivar S090130, to the plants of soybean S090130, to plant parts of soybean cultivar S090130, and to methods for producing a soybean plant produced by crossing soybean cultivar S090130 with itself or with another soybean variety. The invention also relates to methods for producing a soybean plant containing in its genetic material one or more transgenes and to the transgenic soybean plants and plant parts produced by those methods. This invention also relates to soybean cultivars, or breeding cultivars, and plant parts derived from soybean variety S090130, to methods for producing other soybean cultivars, lines or plant parts derived from soybean cultivar S090130, and to the soybean plants, varieties, and their parts derived from use of those methods. The invention further relates to hybrid soybean seeds, plants, and plant parts produced by crossing the cultivar S090130 with another soybean cultivar.
US08546652B2 Cucumber hybrid PS 14741865 and parents thereof
The invention provides seed and plants of cucumber hybrid PS 14741865 and the parent lines thereof. The invention thus relates to the plants, seeds and tissue cultures of cucumber hybrid PS 14741865 and the parent lines thereof, and to methods for producing a cucumber plant produced by crossing such plants with themselves or with another cucumber plant, such as a plant of another genotype. The invention further relates to seeds and plants produced by such crossing. The invention further relates to parts of such plants, including the fruit and gametes of such plants.
US08546651B2 Cucumber hybrid PS 14727140 and parents thereof
The invention provides seed and plants of cucumber hybrid PS 14727140 and the parent lines thereof. The invention thus relates to the plants, seeds and tissue cultures of cucumber hybrid PS 14727140 and the parent lines thereof, and to methods for producing a cucumber plant produced by crossing such plants with themselves or with another cucumber plant, such as a plant of another genotype. The invention further relates to seeds and plants produced by such crossing. The invention further relates to parts of such plants, including the fruit and gametes of such plants.
US08546649B2 White wall rocket cultivar 40-0801185-B
A white wall rocket cultivar, designated 40-0801185-B, is disclosed. The invention relates to the seeds of white wall rocket cultivar 40-0801185-B, to the plants of white wall rocket cultivar 40-0801185-B, and to methods for producing a white wall rocket plant by crossing the cultivar 40-0801185-B with itself or another white wall rocket cultivar. The invention further relates to methods for producing a white wall rocket plant containing in its genetic material one or more transgenes and to the transgenic white wall rocket plants and plant parts produced by those methods. This invention also relates to white wall rocket cultivars or breeding cultivars and plant parts derived from white wall rocket cultivar 40-0801185-B, to methods for producing other white wall rocket cultivars, lines or plant parts derived from white wall rocket cultivar 40-0801185-B and to the white wall rocket plants, varieties, and their parts derived from the use of those methods. The invention further relates to hybrid white wall rocket seeds, plants, and plant parts produced by crossing cultivar 40-0801185-B with another white wall rocket cultivar.
US08546644B2 Recombinant gene which enhances the ability of fish to tolerate low dissolved oxygen stress and the use thereof
The invention discloses a recombinant gene which enhances the ability of fish to tolerate low dissolved oxygen (DO) stress and the use thereof. Carp β-actin gene promoter is used as a promoter and Vitreoscilla hemoglobin gene is used as a target gene, so as to construct the recombinant Vitreoscilla hemoglobin gene driven by carp β-actin promoter. The modeling organism zebrafish is used as the research object, and the recombinant gene is microinjected into zygotes of zebrafish. After PCR screening and 156 h low DO stress test, transgenic fish are obtained with a survival rate of 92%, which is significantly different from the survival rate of 65% of the control fish group. The vhb transgenic zebrafish obtain hypoxia tolerance. When the recombinant gene is applied to the economically farmed species, i.e., blunt snout bream (Megalobrama amblycephala) and common carp (Cyprinus carpio L.), it enhances their hypoxia tolerance as well. Such genetically improved breeding technique may be widely used for breeding new excellent farmed species with the hypoxia tolerance.
US08546636B1 Method for gasifying feedstock
A method of gasification using a downdraft gasifier having a plurality of vertically positioned tubes to create a pyrolysis zone, an oxidation zone beneath the pyrolysis zone and a reduction zone beneath the oxidation zone. The shape of the tubes eliminates the need for a restriction (hearth) in the gasifier, which limits the maximum achievable throughput. A rotating and vertically adjustable grate is located beneath, but not attached to, the reduction zone of the gasifier.
US08546634B2 Method for production of conjugated diolefin
There is provided a method for production of a conjugated diene from a monoolefin having four or more carbon atoms by a fluidized bed reaction. The method for production of a conjugated diolefin includes bringing a catalyst in which an oxide is supported on a carrier into contact with a monoolefin having four or more carbon atoms in a fluidized bed reactor in which the catalyst and oxygen are present, wherein the method satisfies the following (1) to (3): (1) the catalyst contains Mo, Bi, and Fe; (2) a reaction temperature is in the range of 300 to 420° C.; and (3) an oxygen concentration in a reactor outlet gas is in the range of 0.05 to 3.0% by volume.
US08546633B2 Method for producing alkylated aromatic compound, method for producing cumene, and method for producing phenol
A method for producing an alkylated aromatic compound includes a step (i) of producing a reaction product (a1) containing the alkylated aromatic compound and water by the reaction of an aromatic compound, a ketone, and hydrogen using a metal component containing at least one metallic element of copper, nickel, cobalt, and rhenium and a solid acid substance; a step (ii) of forming a dehydrated product (a2) from at least a portion of the reaction product (a1) by removing at least a portion of the water in the reaction product (a1); and a step (iii) of producing a reaction product (a3) containing the alkylated aromatic compound by bringing at least a portion of the dehydrated product (a2) into contact with a solid acid substance.
US08546631B2 Methods for removing unsaturated aliphatic hydrocarbons from a hydrocarbon stream using activated carbon
Disclosed is a method for removing unsaturated aliphatic compounds from a hydrocarbon feed stream by contacting the hydrocarbon feed stream with activated carbon to produce a hydrocarbon effluent stream having a lower unsaturated aliphatic content relative to the hydrocarbon feed stream. The hydrocarbon feed stream comprises an aromatic compound, a nitrogen compound, and an unsaturated aliphatic compound.
US08546628B2 Hydroisomerization process using molecular sieve SSZ-81
The present invention is directed to a hydroisomerization process using a new crystalline molecular sieve designated SSZ-81, which is synthesized using a structure directing agent selected from 1,5-bis(1-azonia-bicyclo[2.2.2]octane)pentane dications, 1,5-bis(1,4-diazabicyclo[2.2.2]octane)pentane dications, and mixtures thereof.
US08546622B2 Process for making ethanol from acetic acid using acidic catalysts
A process for selective formation of ethanol from acetic acid by hydrogenating acetic acid in the presence of a catalyst comprises a first metal on an acidic support. The acidic support may comprise an acidic support material or may comprise an support having an acidic support modifier. The catalyst may be used alone to produced ethanol via hydrogenation or in combination with another catalyst. In addition, the crude ethanol product is separated to obtain ethanol.
US08546619B2 Process for the preparation of bronopol
The invention provides a process for preparing bronopol, which process comprises charging a reaction vessel with water, bromopicrin, nitromethane and paraformaldehyde, gradually feeding a base into said reaction vessel under stirring, bringing the reaction to completion and separating bronopol from the aqueous reaction mixture.
US08546612B2 Phenyl-N-acyl derivatives of amines and amino acids, a process for the preparation thereof, a pharmaceutical composition and use thereof
The present invention relates to novel phenyl-N-acyl derivatives of biogenic amines and amino acids of general formula (I) as cyclooxynease inhibitors, possessing analgetic and anti-inflammatory properties and devoid of side effects in particular ulcerogeneity and pro-spasmodic actions, as well as capability to potentiate effect of other analgetics, and possessing in addition antihypoxic, antidepressant and anti-Parkinsonistic action; as well as to the processes for the preparation novel and known phenyl-N-acyl derivatives of biogenic amines, to a pharmaceutical composition and to an agent comprising compounds of general formula (I) as well as to use thereof and a method of treating.
US08546609B2 Ionic liquid containing allylsulfonate anion
Problem:Providing a novel ionic liquid, which is low-cost, environment-friendly, and has low viscosity and melting point.Means for Solving the Problem:The present invention is the invention of the ionic liquid represented by the general formula [1]: {wherein, R1 to R3 and n pieces of R4 each independently represent hydrogen atom or alkyl group having 1 to 4 carbon atoms, R5 to R7 each independently represent alkyl group, aralkyl group, or aryl group, R8 represents alkyl group, aralkyl group, aryl group, or the one represented by the general formula [2]: (wherein T represents alkylene chain having 1 to 8 carbon atoms, n represents 1 or 2, and R1 to R7 are the same as the above-described), X represents nitrogen atom or phosphorus atom, n represents 1 or 2. When n is 1, R3 and R4 are bound and may form cyclohexene ring together with the adjacent carbon atoms. In addition, when X is nitrogen atom, R5 to R7 or R5 to R6 may form hetero ring with nitrogen atom binding thereto}.
US08546606B2 Method for producing polyisocyanates
The invention relates to a process for preparing polyisocyanates by reacting primary amines with phosgene, which comprises the steps a) mixing the amine with the phosgene, b) reacting the amine with the phosgene in a residence reactor and, if desired, c) transferring the output from the reactor of step b) into a distillation column, wherein the residence reactor in step b) is configured as a tube reactor.
US08546599B2 Tert-butylphenyl sulfonate compound, nonaqueous electrolyte solution for lithium secondary battery using the same, and lithium secondary battery using the same
The disclosed subject matter relate to a di-tert-butylphenyl alkylsulfonate compound, tert-butylphenyl alkylsulfonate compound, di-tert-butylphenyl arylsulfonate compound or tert-butylphenyl arylsulfonate compound useful as an intermediate raw material of a pharmaceutical, agricultural chemical, electronic material or polymer material and the like, or as a battery material, and also provides a nonaqueous electrolytic solution for a lithium secondary battery having superior cycle performance and other battery properties through the use thereof, and a lithium secondary battery. The disclosed embodiments further relate to a nonaqueous electrolytic solution for use as in a lithium secondary battery containing, in a nonaqueous electrolytic solution in which an electrolyte salt is dissolved in a nonaqueous solvent, 0.01 to 10% by weight of a di-tert-butylphenyl alkylsulfonate compound, tert-butylphenyl alkylsulfonate compound, di-tert-butylphenyl arylsulfonate compound or tert-butylphenyl arylsulfonate compound, and to a lithium secondary battery and a compound.
US08546595B2 Halogen substituted heteroatom-containing metallocene compounds for olefin polymerization
Halogen substituted metallocene compounds are described and comprise one or more monocyclic or polycyclic ligands that are pi-bonded to the metal atom and include at least one halogen substituent directly bonded to an sp2 carbon atom at a bondable ring position of the ligand, wherein the or at least one ligand has one or more ring heteroatoms in its cyclic structure. When combined with a suitable activator, these compounds show activity in the polymerization of olefins, such as ethylene and propylene.
US08546594B2 Indium oxoalkoxides for producing coatings containing indium oxide
The present invention relates to halogenated indium oxo alkoxides of the generic formula In6O2X6(OR)6(R′CH(O)COOR″)2(HOR)x(HNR′″2)y where X═F, Cl, Br and/or I, R═C1-C15-alkyl, C1-C15-alkenyl, C1-C15-alkynyl, C1-C15-alkoxyalkyl, C6-C15-aryl- and/or C7-C15-alkoxyaryl, R′═C1-C15-alkyl, C1-C15-alkenyl, C1-C15-alkynyl, C1-C15-alkoxyalkyl, C6-C15-aryl- and/or C7-C15-alkoxyaryl, R″═C1-C15-alkyl, C1-C15-alkenyl, C1-C15-alkynyl, C1-C15-alkoxyalkyl, C6-C15-aryl- and/or C7-C15-alkoxyaryl, R′″═C1-C15-alkyl, C1-C15-alkenyl, C1-C15-alkynyl, C1-C15-alkoxyalkyl, C6-C15-aryl- and/or C7-C15-alkoxyaryl, x=0 to 10 and y=0 to 10, to processes for preparation thereof and to use thereof.
US08546593B2 Methods and compositions for novel liquid crystal delivery systems
Methods of making a liquid crystal mixture essentially comprised of at least one fatty acid ester or fatty acid, at least one polyhydric solvent, and at least one alkali reactant. The resultant mixture includes at least one fatty acid ester or fatty acid, at least one polyhydric solvent, and at least one salt of said fatty acid ester or fatty acid. The resultant mixture exhibits enhanced stability and aqueous solubility of fatty acids and fatty acid esters. When medium chain fatty acid monoglycerides are used in the method, the resultant mixture exhibits antimicrobial efficacy.
US08546591B2 Method for producing cis-rose oxide
The present invention relates to a process for the preparation of cis-2-(2-methylprop-1-enyl)-4-methyltetrahydropyran comprising the catalytic hydrogenation of 2-(2-methylprop-1-enyl)-4-methylenetetrahydropyran in the presence of hydrogen and a heterogeneous catalyst comprising ruthenium on a support and subsequently bringing the compounds obtained in this way into contact with a strongly acidic cation exchanger.
US08546590B2 Polar dyes
The present invention relates to novel polar fluorescent and quenchers dyes, and minor groove binder with enhanced polarity. The present invention further relates to methods of preparing oligonucleotide probes labeled with polar arsonate dyes under the condition of automated synthesis and method of using such probes.
US08546589B2 Organophosphorus compounds, catalytic systems comprising said compounds and method of hydrocyanation using said catalytic systems
Organophosphorus compounds are described that belong to the phosphinite-phosphite family. Catalytic systems comprising a metallic element forming a complex with said phosphinite-phosphite compounds and methods of hydrocyanation employed in the presence of said catalytic systems are also described.
US08546587B2 Method for producing acrylate derivative, acrylate derivative, and intermediate thereof
Provided are 1) a production process for an acrylic ester derivative capable of being a raw material of a polymer for obtaining a photoresist composition capable of forming a photoresist film which is excellent in a reactivity to acid and a heat stability and is less swollen in developing and which has a refractive index of preferably 1.72 or more in 193 nm and can be patterned, 2) an acrylic ester derivative obtained by the above production process and 3) alcohol and ester which are synthetic intermediates for the above acrylic ester derivative.
US08546585B2 Process for preparing eprosartan mesylate
The present invention discloses a process for preparing eprosartan mesylate, in which eprosartan is dissolved or suspended in glacial acetic acid, then methanesulfonic acid is added and a solution of eprosartan mesylate in glacial acetic acid is obtained by stirring, a solid of eprosartan mesylate is precipitated by continuously stirring and then obtained by filtration, or a solid of eprosartan mesylate is obtained by concentrating the glacial acetic acid to dry, or a solid of eprosartan mesylate is obtained by adding dropwise an organic ester solvent into the glacial acetic acid under stirring to precipitate a crystal and separate the crystal.
US08546584B2 Benzoxazole derivative, light-emitting element, light-emitting device, electronic device, and lighting device
A novel benzoxazole derivative having high excitation energy, particularly high triplet excitation energy is provided. A light-emitting element having high current efficiency is provided by application of the novel benzoxazole derivative for the light-emitting element. A light-emitting device, an electronic device, and a lighting device each having reduced power consumption are provided. The benzoxazole derivative is represented by General Formula (G1). In the formula, R11 to R14 and R21 to R27 separately represent any one of hydrogen, an alkyl group having 1 to 4 carbon atoms, and a substituted or unsubstituted aryl group having 6 to 13 carbon atoms, Ar represents a substituted or unsubstituted arylene group having 6 to 13 carbon atoms, and Z represents either a sulfur atom or an oxygen atom.
US08546583B2 Compounds as cannabinoid receptor ligands and uses thereof
The present invention relates to compounds of formula (I), or pharmaceutical salts, prodrugs, salts of prodrugs, or combinations thereof, wherein R1, R2, R3, R4, and L1 are defined in the specification, compositions comprising such compounds, and methods of treating conditions and disorders using such compounds and compositions. The present invention also relates to compounds of formula (II), or pharmaceutical salts, prodrugs, salts of prodrugs, or combinations thereof, wherein R1a, R2a and (Rx)n are as defined in the specification, compositions comprising such compounds, and methods of treating conditions and disorders using such compounds and compositions.
US08546581B2 Compounds, methods and formulations for the oral delivery of a glucagon-like peptide (Glp)-1 compound or a melanocortin-4 receptor (Mc4) agonist peptide
The present application relates to novel compounds, methods and formulations useful for the oral delivery of a glucagon like peptide-1 compound or a melanocortin 4 receptor agonist peptide.
US08546576B2 3 or 4-substituted piperidine compounds
There are disclosed racemic or enantiomerically enriched 3- or 4-substituted piperidine compounds represented by the following structural formula (I): or any of their isomers, or pharmaceutically acceptable salts thereof. Also disclosed are pharmaceutical compositions containing the subject compounds. The subject compounds are useful for the treatment of diseases of the central nervous system, particularly depression, anxiety and pain disorder.
US08546573B2 Process for the preparation of 7-ethyl-10-[4-(1-piperidino)-1-piperdino] carbonyloxy-camptothecin hydrochloride trihydrate
The present invention relates to process for the preparation of 7-ethyl-10-[4-(1-piperidino)-1-piperidino]carbonyloxy-camptothecin hydrochloride trihydrate and process for the isolation of 1-chlorocarbonyl-4-piperidinopiperidine and novel crystalline form of 1-chlorocarbonyl-4-piperidinopiperidine and 7-ethyl-10-[4-(1-piperidino)-1-piperidino]carbonyloxy-camptothecin.
US08546563B2 Compounds which modulate the CB2 receptor
Compounds of formula (I) are disclosed. Compounds according to the invention bind to and are agonists of the CB2 receptor, and are useful for treating inflammation. Those compounds which are agonists are additionally useful for treating pain.
US08546559B2 Modified galactomannan ethers
Cationic hydrophobically modified galactomannan ethers having a cationic degree of substitution (DSC) from 0.01 to 0.5 and hydrophobic degree of substitution (DSH) below 0.001 are readily soluble in aqueous systems and useful to thicken, stabilize and condition cosmetics, detergent compositions and household cleaning products; they further improve the deposition of other ingredients on the treated surface (skin, hair or fabric).
US08546558B2 Method for the manufacture of microfibrillated cellulose
A method of treating chemical pulp for the manufacture of microfibrillated cellulose includes the following steps: a) providing a hemicellulose containing pulp, b) refining the pulp in at least one step and treating the pulp with one or more wood degrading enzymes at a relatively low enzyme dosage, and c) homogenizing the pulp thus providing the microfibrillated cellulose. A microfibrillated cellulose obtainable by the method is also provided. The microfibrillated cellulose can be used in food products, paper products, composite materials, coatings or in rheology modifiers (e.g. drilling muds).
US08546551B2 Method to detect prostate cancer in a sample
The present invention provides methods to detect prostate cancer by detecting the RNA encoded by PCA3. The disclosure provides a method for determining a predisposition, or presence of prostate cancer comprising: (a) contacting a sample with at least one oligonucleotide that hybridizes to a PCA3 polynucleotide; (b) detecting an amount of PCA3 and second prostate-specific polynucleotides; and (c) comparing the amount of PCA3 polynucleotide that hybridizes to the oligonucleotide to a predetermined cut off value, and determining the presence or absence of prostate cancer. Diagnostic kits are provided for detecting prostate cancer or the risk of developing same comprising: (a) at least one container means containing at least one oligonucleotide probe or primer that hybridizes to PCA3 (b) at least one oligonucleotide probe or primer that hybridizes with a second prostate specific nucleic acid; and (c) reagents for detecting PCA3 and the second prostate specific nucleic acid.
US08546550B2 Immunostimulatory oligonucleotides
Compositions that include immunostimulatory nucleic acids are disclosed, along with the use of such compositions to induce immune responses.
US08546536B2 Genetically engineered G-alpha proteins and uses thereof
The present invention relates to novel engineered Ga proteins and assay methods of using such proteins to advance drug discovery. Engineered Ga proteins described by the invention contain alterations of at least one and preferably two or more amino acid residues that are highly conserved among all four subfamilies of Ga proteins. A preferred engineered protein disclosed here is a double mutant, Gαπ R178M A326S. This specific combination of mutations yields an unexpectedly amplified effect on Ga function both in terms of GTPase activity (GTP hydrolysis) and GDP dissociation. This synergistic effect may have a profound influence on the way GPCR signaling pathways are examined for the development of new pharmacotherapies, particularly in the field of central nervous system disorders such as Parkinson's disease.
US08546533B2 Pipecolic linker and its use for chemistry on solid support
The present invention relates to a pipecolic linker and its use as a solid-phase linker in organic synthesis. Said pipecolic solid-phase linker may be used for coupling functional groups chosen between primary amines, secondary amines, aromatic amines, alcohols, phenols and thiols. In particular, said pipecolic solid-phase linker may be used for peptide or pseudopeptide synthesis, such as the reverse N to C peptide synthesis or the retro-inverso peptide synthesis, or for the synthesis of small organic molecules.
US08546529B2 Injectable bone regeneration gel containing bone formation enhancing peptide
The present invention relates to an injectable bone regeneration material containing a bone formation enhancing peptide, and more particularly, to an injectable bone regeneration material, in which a bone formation enhancing peptide essentially containing one and more amino acid sequences among SEQ ID NO: 1 to SEQ ID NO: 28 is bonded or mixed to a gel-forming base material selected from the group consisting of chitosan, alginic acid, silk fibroin, propylene glycol, propylene glycol alginic acid, poloxamer, chondroitin sulphate, and the combination thereof. The injectable bone regeneration material according to the present invention can increase differentiation of bone marrow stromal cells and osteoblasts into bone tissue, thus maximizing tissue regeneration by a peptide capable of promoting differentiation of bone tissue and periodontal tissue regeneration. The injectable bone regeneration material is in the form of a gel, and thus can be applied to a surface of various medical devices such as implant etc., and can be mixed with bone graft particles to apply, so that it can increase a treatment effect of existing medical devices to maximize a tissue regeneration effect.
US08546512B2 Copolymer containing fluorenylporphyrin-benzene, preparation method and use thereof
A copolymer containing fluorenylporphyrin-benzene is disclosed, which comprises a copolymer represented by formula (1), in which R1, R2, R3 and R4, which may be identical or different, are C1-C16 alkyl, and n is an integer of 1 to 100. The preparation method of said copolymer containing fluorenylporphyrin-benzene and the use thereof in manufacture of solar batteries components, organic field effect transistors, organic electroluminescent components, organic optical storage components, organic non-linear materials or organic laser components are also disclosed.
US08546511B2 Polyamideimide resin for flexible printed circuit boards; metal-clad laminate, coverlay, and flexible printed circuit board that use this resin; and resin composition
The present invention provides a polyamideimide resin for flexible printed circuit boards that prior to curing exhibits an excellent solubility, processability, and handling characteristics, and that after curing exhibits flame retardancy, solder heat resistance, circuit embeddability, and flexibility and further has a high glass-transition temperature (Tg) and is able to maintain a high adhesive strength. The present invention provides a polyamideimide resin for flexible printed circuit boards, which is obtained by the polymerization reaction of an acid component comprising at least a monoanhydride and an aromatic dicarboxylic acid with a diisocyanate compound or diamine compound in an approximately equimolar amount with respect to the total molar amount of the acid component, wherein the molar amount of the monoanhydride is 0.4 to 0.8 taking the total molar amount of the acid component as 1.
US08546509B2 Functionalized particles
Functionalized particles having fully formed shells and cores comprising a polyurethane or polyurea matrix obtained by interfacial addition polymerisation of (i) at least one polyisocyanate derivative selected from the group of partially blocked polyisocyanates and polyisocyanates partially modified with fiber reactive groups and (ii) at least one polyamine or polyhydric alcohol, said functionalized particles being capable to chemically or physically bind to a substrate.
US08546506B2 Polymerization of isoprene from renewable resources
The invention features compositions and methods for producing polymers of isoprene derived from renewable resources such as isoprene produced from cultured cells that use renewable carbon sources. A starting isoprene composition, such as a bioisoprene composition, is distinguished from petroleum based isoprene by the purity profile (such as lower levels of certain C5 hydrocarbons other than isoprene, presence of certain compounds associated with the biological process for production) and the relative content of the carbon isotopes. Polymers obtained by polymerization of such starting isoprene composition according to this invention, such as a polyisoprene homopolymer or a copolymer having repeat units that are derived from isoprene, are distinguishable from isoprene containing polymers from petrochemical resources. The present invention more specifically discloses a polyisoprene polymer which is comprised of repeat units that are derived from isoprene monomer, wherein the polyisoprene polymer has δ13C value of greater than −22‰. This type of polyisoprene can be a cis-1,4-polyisoprene homopolymer rubber. Also provided are methods for verifying that a polyisoprene homopolymer or a copolymer having repeat units that are derived from isoprene contains isoprene that is from a sustainable renewable non-petroleum derived source.
US08546504B2 Extrusion processes using high melt strength polypropylene
The present invention relates to a process comprising extruding a blend of an first propylene polymer comprising a non-phenolic stabilizer and a non-irradiated second propylene polymer, wherein the irradiation of the first propylene polymer was conducted in a reduced oxygen environment, and the irradiated first propylene polymer and the non-irradiated second propylene polymer were blended at a temperature below the melting point of the first and second propylene polymers.
US08546502B2 Method for producing dye polymer, dye polymer and use of the same
Disclosed are a production process of a dye polymer having a dye content of from 1 to 50 wt %, and the dye polymer and its use. The production process includes subjecting an addition-polymerizable monomer to living radical polymerization by using, as a polymerization initiator, a dye having a polymerization initiating group enabling the living radical polymerization. The dye polymer and a composition of the dye polymer and a pigment are useful as good coloring agents for various products or articles. The colored products or articles are high in transparency, and are provided with high added value. The dye polymer can also be used as a dispersant for pigments, thereby making it possible to afford pigment dispersions excellent in dispersion properties and dispersion stability.
US08546500B2 Complexes for use in metathesis reactions
The present invention relates generally to metal complexes, methods for preparation and uses of the same.
US08546499B2 Linear low density polyethylene with uniform or reversed comonomer composition distribution
Ziegler-Natta catalyzed linear low density polyethylene which satisfies the following conditions:a) a density, according to ISO 1183, of from 900 to 925 kg/m3,b) a C4-C10-comonomer content, determined by Fourier transform infrared spectroscopy, of 1 to 16 wt %c) a weight average molecular weight Mw, determined by gel permeation chromatography, of at least 200 000,d) wherein the linear low density polyethylene comprises, by Crystallisation Analysis Fractionation (CRYSTAF) an amorphous fraction soluble at a temperature below 30° C. of at most 10 wt % and a fraction crystallising between 60 to 75° C. of at least 35 wt % ande) by temperature rising elution fractionation (TREF) analysis, at least 70 wt % of a crystallising polymer component having an elution temperature range from 60° C. to 94° C. and less than 10 wt % of a crystallising polymer component having an elution temperature range from 30° C. to 60° C. and,f) by Gel Permeation chromatography coupled with Fourier transform infrared spectroscopy detector (GPC-FTIR), a substantially constant short chain branching profile across the molecular weight distribution (MWD) org) by Gel Permeation chromatography coupled with Fourier transform infrared spectroscopy instruments (GPC-FTIR), a reverse short chain branching profile across the molecular weight distribution (MWD),the linear low density polyethylene being produced in the presence of a special Ziegler-Natta procatalyst and a halogenated aluminium alkyl cocatalyst of the formula (IV) (C1-C4- alkyl)m-Al-X3−m, wherein X is chlorine, bromine, iodine or fluorine and m is 1 or 2.
US08546495B2 Polyaniline-added prepolymer, method of manufacturing polyaniline-added prepolymer, polyaniline graft polymer, method of manufacturing polyaniline graft polymer, cross-linked material, and paint
Polyaniline is added into a glycidyl group- or isocyanate group-containing (meth)acrylate to obtain a polyaniline-added prepolymer, and then the obtained polyaniline-added prepolymer and another unsaturated group-containing monomer undergo additive copolymerization at their respective double bonds to obtain a polyaniline graft polymer having a weight-average molecular weight of 1,000 to 100,000.
US08546492B2 Surface treatment method for water-absorbing resin and production method for water-absorbing resin
The present invention provides a surface treatment method for a water-absorbing resin comprising three steps of: 1) a humidifying and mixing step for mixing a base polymer and a surface cross-linking agent solution to obtain a “humidified substance”; 2) a pretreatment step for raising temperature of said humidified substance to obtain a “pretreated substance”; and 3) a surface cross-linking reaction step for cross-linking said pretreated substance to obtain a surface cross-linked “water-absorbing resin”; wherein dew point in the pretreatment step of the above 2) is from 50° C. to 95° C., and temperature of said humidified substance is raised from temperature below the dew point up to a temperature of 10° C. higher than the dew point.
US08546489B2 Polymer blend compositions
Provided are filled polyimides that can be used in films and articles comprising the films. The films are useful in coverlay applications and have advantageous optical properties. Also provided are blends of polyimide precursor, polyacrylonitrile, and cellulosic polymer which can be used to obtain the filled polyimides.
US08546488B2 Cleavable block copolymers, functionalized nanoporous thin films and related methods of preparation
Cleavable, disulfide-coupled block copolymers as can be used in the preparation of nanoporous thin films, micellar configurations and related structures.
US08546479B2 Aqueous binders for coatings with improved gloss
A water-reducible mixture of (meth)acrylic copolymers having a hydroxyl number of from 40 mg/g to 250 mg/g, an acid number of from 15 mg/g to 80 mg/g, a weight average molar mass Mw from 9 kg/mol to 40 kg/mol and a glass transition temperature Tg from −40° C. to 80° C., based on polymerised monomers comprising at least one alkyl ester A of an olefinically un-saturated carboxylic acid having from 1 to 8 carbon atoms in the alkyl group, at least one hydroxy functional alkyl ester B of an olefinically unsaturated carboxylic acid, at least one aliphatic compound C that has both hydroxy and carboxyl functionalities, or which is a lactone or a cyclic lactone, at least one vinyl monomer D which does not comprise a moiety derived from an olefinically unsaturated carboxylic acid, at least one olefinically unsaturated carboxylic acid E, a process for its preparation, and a method of use thereof in the preparation of paints.
US08546477B2 Coating composition, method of producing the same, articles made therefrom, and method of making such articles
The process for producing the coating composition according to the instant invention comprises the steps of: (1) providing an ethylene based copolymer composition; (2) providing a propylene polymer composition; (3) providing a chlorinated olefin polymer composition; (4) optionally providing a filler; (5) optionally providing an adhesion promoting agent; and (6) melt blending said ethylene based copolymer composition, said propylene polymer composition, said chlorinated olefin polymer composition, said optional filler and said optional adhesion promoting agent. The articles according to the instant invention comprise optionally a substrate; and a coating. The method for making the inventive articles comprises the steps of (1) providing a substrate; (2) providing a coating composition; and (3) coating said coating composition into onto at least one surface of said substrate.
US08546476B2 Exoergic filler composition, resin composition, exoergic grease and exoergic coating composition
The present disclosure provides an exoergic filler composition which is able to exert superior exoergic property, and a resin composition, a grease, and a coating composition which having superior exoergic property, respectively, by using the above-mentioned exoergic filler composition. The exoergic filler composition contains 1 to 50 volume % of a needle-shaped zinc oxide having an average long diameter of 0.1 to 10 μm, an average short diameter of 0.025 to 2.5 μm, aspect ratio defined by (average long diameter)/(average short diameter) of 4 or more and specific surface area according to BET method of 50 m2/g or less, and 50 to 99 volume % of other exoergic filler.
US08546471B2 Waterborne adhesive with improved wet adhesion
A Waterborne adhesive comprising 1 to 50 weight-% of a (meth)acrylate copolymer manufactured by polymerization of at least one ester of methacrylic acid, acrylic acid, crotonic acid and/or itaconic acid with aliphatic alcohols, substituted aliphatic alcohols, aromatic alcohols, polyether glycols, and other copolymerizable monomers, having an acid number from 0 to 150 mgKOH/g, 0 to 40 wt-% of natural polymers 0.5 to 30 wt-% of urea, 0.1 to 20 wt-% of additives, characterized in that the adhesive contains 0.05 to 20 weight-% of a super absorbent polymer.
US08546470B2 Cellulosic inclusion thermoplastic composition and molding thereof
A cellulosic inclusion-thermoplastic composition that includes cellulosic inclusions and a thermoplastic polyolefin that forms a matrix in which the cellulosic inclusions are dispersed. A maleated polymer and a polar thermoplastic polymer resin of a polyamide or polyester are provided to improve adhesion between the cellulosic inclusions and the thermoplastic polyolefin. The polar thermoplastic polymer resin is characterized by a melting temperature greater than that of the thermoplastic polyolefin. The composition as provided has increased break tensile strength relative to a composition devoid of the polar thermoplastic polymer resin but otherwise is unchanged. The break tensile is measured at 23° Celsius and at an elongation rate of 50 millimeters per minute.
US08546468B2 Method and device for the continuous production of polymers by radical polymerization
The present invention relates to a method for the continuous production of a polymer by radical polymerization, wherein at least three materials are mixed with microstructures in one or more mixers and are then polymerized in at least one reaction zone.
US08546463B2 Dental adhesive composition
Dental composition comprising an aqueous mixture containing (i) a polymerizable acidic phosphoric acid ester monomer of the following formula (A): wherein a is an integer of from 1 to 10; R1 represents a hydrogen atom or a moiety of the following formula (Y) wherein X independently represent an oxygen atom, a sulfur atom, or a group NR, wherein R may be a hydrogen atom, a C1-6 alkyl group or an acyl group; L represents an (a+b)-valent organic residue containing 1 to 20 carbon atoms and optionally including ether, thioether or amino groups or further acidic groups, whereby the carbon atoms comprise at least a+b carbon atoms selected from primary and secondary aliphatic carbon atoms, secondary alicyclic carbon atoms, and aromatic carbon atoms, each of said a+b carbon atoms linking a phosphate or 2-(oxaallyl) derivative group; b is an integer of from 1 to 10; R2 which may be the same or different, independently may be hydrogen, an allyl group or a moiety R1 wherein b is 1; provided that at least one of R1 and R2 is not hydrogen; (ii) one or more polymerizable N-substituted alkyl acrylic or acrylic acid amide monomers; (iii) an organic water-miscible solvent and/or water; (iv) a polymerization initiator; (v) an inhibitor and/or a stabilizer; (vi) optionally an organic or inorganic acid; and (vii) optionally a filler and/or a fluoride releasing compound.
US08546457B2 Method for the production of abrasive foams
A process for production of an abrasive foam based on a melamine-formaldehyde condensate comprising inorganic nanoparticles, comprising the steps of: (1) preparation of a solution or dispersion comprising a precondensate of the foam to be produced, and also comprising inorganic nanoparticles, (2) foaming of the precondensate via heating of the solution or dispersion from step (1), in order to obtain a foam which comprises inorganic nanoparticles, and also, if appropriate, (3) heat-conditioning of the foam obtained in step (2), leads to improved abrasion in the polishing of delicate surfaces.
US08546456B2 Fracture fixation systems
Systems for bone fracture repair are disclosed. One system includes a biocompatible putty that may be packed about a bone fracture to provide full loadbearing capabilities within days. The disclosed putties create an osteoconductive scaffold for bone regeneration and degrade over time to harmless 5 resorbable byproducts. Fixation devices for contacting an endosteal wall of an intramedullary (IM) canal of a fractured bone are also disclosed. One such fixation device includes a woven elongated structure fabricated from resorbable polymer filaments. The woven elongated structure has resilient properties that allow the woven 10 structure to be radially compressed and delivered to the IM canal using an insertion tube. When the insertion tube is removed, the woven structure expands towards its relaxed cross-sectional width to engage the endosteal wall. The woven elongated structure is impregnated with a resorbable polymer resin that cures in situ, or in the IM canal.
US08546454B2 Process and method for the producton of dimethylether (DME)
Disclosed herein is a process for the production of fuel grade DME from carbonaceous fuels, including a pressurized multi-stage progressively expanding fluidized bed gasifier and an oxyblown autothermal reformer to produce a synthesis gas (syngas) with desirable hydrogen to carbon monoxide molar ratio, which then undergoes gas-phase DME one-step direct synthesis in a fluid pluralized bed reactor over an attrition resistant bifunctional catalyst. The crude DME thus obtained is purified in a two column distillation unit to produce a fuel grade DME having a purity greater than 99.98 mole %.
US08546451B2 Estrogen receptor ligands and methods of use thereof
The present invention relates to methods of treating androgen deprivation therapy (ADT) induced hot flashes and severe hot flashes in a subject.
US08546448B2 3-substituted compounds for reducing uric acid
A process for forming a solid electrolytic capacitor and an electrolytic capacitor formed by the process. The process includes: providing an anode wherein the anode comprises a porous body and an anode wire extending from the porous body; applying a thin polymer layer onto the dielectric, and forming a dielectric on the porous body to form an anodized anode; applying a first slurry to the anodized anode to form a blocking layer wherein the first slurry comprises a first conducting polymer with an median particle size of at least 0.05 μm forming a layer of crosslinker on the blocking layer; and applying a layer of a second conducting polymer on the layer of crosslinker.
US08546445B2 Oral composition
A composition which is adapted for oral consumption comprising daidzein and an anthocyanidin, wherein the weight ratio of daidzein to anthocyanidin is in the range of from 1:1 to 1:100, wherein the daidzein is in the form of a pre-prepared aqueous dispersion, and wherein the composition is free of soy protein, which can exhibit an anti-inflammatory effect in skin, the use of a composition containing daidzein and an anthocyanidin for obtaining an anti-inflammatory effect in the skin and a method of reducing skin inflammation through the oral consumption of the composition.
US08546444B2 Synthetic lactone formulations and method of use
Natural and synthetic compounds having a lactone structure methods for alleviation of pain, especially pain associated with disorders such as melanoma, leukemia, breast cancer, lung cancer, ovarian cancer, colon cancer, esophagus cancer, liver cancer, and lymphatic cancer. Initial studies have shown that patients can be taken off of morphine when the preferred alpha-methylene-gamma-butyrolactone is administered in a dosage of between 60 and 120 mg/day intramuscularly.
US08546438B2 Substituted (thiophenyl-carbonyl)imidazolidinones, and use thereof
The present invention relates to novel substituted (thiophenyl-carbonyl)imidazolidinones, methods for their production, their use for the treatment and/or prevention of diseases, as well as their use for the production of medicaments for the treatment and/or prophylaxis of diseases, especially retroviral diseases, in humans and/or animals.
US08546437B2 Compounds and compositions and methods of use
Described herein are compounds useful in the modulation of blood uric acid levels, formulations containing them and methods of using them. In some embodiments, the compounds described herein are used in the treatment or prevention of disorders related to aberrant levels of uric acid.
US08546431B2 5-lipoxygenase-activating protein (FLAP) inhibitors
A method for treating a human comprises administering a therapeutically effective amount of 3-[3-tert-butylsulfanyl-1-[4-(6-methoxy-pyridin-3-yl)-benzyl]-5-(pyridin-2-ylmethoxy)-1H-indol-2-yl]-2,2-dimethyl-propionic acid or a pharmaceutically acceptable salt or a pharmaceutically acceptable N-oxide thereof, to the human in need.
US08546427B2 Tetrahydroquinoline derivatives
The present invention relates to compounds according to formula (I) and pharmaceutically acceptable salts or esters thereof, wherein R1 to R7 have the significance given herein. The compounds are activators of AMP-activated protein kinase (AMPK) and are useful in the treatment or prophylaxis of diseases that are related to AMPK regulation, such as obesity, dyslipidemia, hyperglycemia, type 1 or type 2 diabetes and cancers.
US08546426B2 N-aminotetrahydroisoquinolines as anti-cancer agents
The compounds herein disclosed are tetrahydroisoquinoline analogs that have modifications on the phenyl rings by introducing groups with various electronic properties. These derivatives of tetrahydroisoquinoline have been shown to have anti-proliferative activity against cells. In particular, the compounds have been found to be effective in inhibiting the proliferation of cancer cells, such as cancer cells that originated in breast tissue. Additionally, it has been shown that the novel compounds have IC50 values against the breast cancer cells that are 6-10-fold less than the IC50 of tamoxifen.
US08546424B2 Acetylene derivatives of 5-phenyl-pyrazolopyridine, preparation thereof, and therapeutic use thereof
Compounds of formula (I): in which: R1 and R2 represent, independently of one another, a hydrogen atom or a (C1-C6)alkyl group, R3 represents one or more hydrogen or halogen atoms, X represents from 1 to 4 substituents, identical to or different from one another, chosen from hydrogen, halogen or (C1-C6)alkyl, in the form of the base or of an addition salt with an acid. Therapeutic use and synthetic process.
US08546423B2 Aerosolized fluoroquinolones and uses thereof
Disclosed herein are formulations of fluoroquinolones suitable for aerosolization and use of such formulations for aerosol administration of fluoroquinolone antimicrobials for the treatment of pulmonary bacterial infections. In particular, inhaled levofloxacin specifically formulated and delivered for bacterial infections of the lungs is described. Methods include inhalation protocols and manufacturing procedures for production and use of the compositions described.
US08546417B2 Fused and spirocycle compounds and the use thereof
The invention relates to fused and spirocycle compounds of Formula I: or a pharmaceutically acceptable salt, prodrug, or solvate thereof, wherein R1, R2, Q1-Q3, and Z are defined as set forth in the specification. The invention is also directed to the use of compounds of Formula I to treat, prevent or ameliorate a disorder responsive to the blockade of calcium channels, and particularly N-type calcium channels. Compounds of the present invention are especially useful for treating pain.
US08546416B2 3-spirocyclic piperidine derivatives as ghrelin receptor agonists
The invention relates to derivatives of formula (I), wherein the substituents are as defined in the specification; to processes for the preparation of such derivatives; pharmaceutical compositions comprising such derivatives; such derivatives as a medicament; such derivatives for the treatment of a disorder or a disease mediated by the ghrelin receptor.
US08546410B2 Heteroaryl-fused macrocyclic pyrimidine derivatives
Heteroaryl-fused macrocyclic 2,4-diaminopyrimidine compounds of formula (I) wherein W, G1, G2, A1 and R1 are defined in the description, compositions comprising such compounds, methods for making the compounds, and methods of treating and preventing the progression of diseases, conditions, and disorders using such compounds and compositions are described herein.
US08546409B2 Methods of treatment for solid tumors
The invention provides methods that relate to a novel therapeutic strategy for the treatment of hematological malignancies and inflammatory diseases. In particular, the method comprises administration of a compound of formula I, or a pharmaceutically acceptable salt thereof, or a pharmaceutical composition comprising such compound admixed with at least one pharmaceutically acceptable excipient.
US08546399B2 Apoptosis inducing agents for the treatment of cancer and immune and autoimmune diseases
Disclosed are compounds which inhibit the activity of anti-apoptotic Bcl-2 proteins, compositions containing the compounds and methods of treating diseases during which is expressed anti-apoptotic Bcl-2 protein.
US08546395B2 6-cycloamino-3-(1H-pyrrolo[2,3-b]pyridin-4-yl)imidazo[1,2-b]pyridazine derivatives, preparation thereof and therapeutic use thereof
The invention relates to 6-cycloamino-3-(1H-pyrrolo[2,3-b]pyridin-4-yl)imidazo[1,2-b]pyridazine derivatives corresponding to the general formula (I) in which R2 represents an aryl group optionally substituted with one or more halogen atoms or C1-6-alkyl, C1-6-alkyloxy, C1-6-alkylthio, C1-6-fluoroalkyl, C1-6-fluoroalkyloxy and —CN groups or R2 represents a group chosen from C1-6-alkyl, C1-6-fluoroalkyl, C3-7-cycloalkyl or C3-7-cycloalkyl-C1-6-alkyl groups; A represents a C1-7-alkylene group; B represents a C1-7-alkylene group; L represents either a nitrogen atom optionally substituted with an Rc or Rd group, or a carbon atom substituted with an Re1 group and an Rd group or two Re2 groups; the carbon atoms of A and of B being optionally substituted with one or more Rf groups, which may be identical to or different from one another. Preparation process and therapeutic use.
US08546392B2 17Beta-hydroxysteroid dehydrogenase type 1 inhibitors for the treatment of hormone-related diseases
The invention relates to the use of non-steroidal 17beta-hydroxysteroid dehydrogenase type 1 inhibitors for the treatment and prophylaxis of hormone-dependent, particularly estrogen-dependent, diseases. The invention further relates to suitable inhibitors and to a method for the production thereof.
US08546391B2 Thiadiazole and oxadiazole derivatives, preparation thereof and therapeutic use thereof
The invention relates to compounds of the formula (I) either (i) in the state of a base or an acid addition salt, or (ii) in the state of an acid or a base addition salt, as well as to a method for preparing same and to the therapeutic applications thereof.
US08546390B2 6-(pyrrolopyridinyl) pyrimidin-2-ylamine derivatives and the use thereof for the treatment of cancer and AIDS
Compounds of the formula (I), in which R1, R2, R3 and R4 have the meanings indicated in claim (1), are inhibitors of cell proliferation/cell vitality and can be employed for the treatment of tumors.
US08546388B2 Heterocyclic TRPV1 receptor ligands
The invention relates to compounds of formulae I(a)-I(d): and pharmaceutically acceptable derivatives thereof, compositions comprising an effective amount of a compound of formulae I(a)-I(d) or a pharmaceutically acceptable derivative thereof, and methods for treating or preventing a condition such as pain, UI, an ulcer, IBD and IBS, comprising administering to an animal in need thereof an effective amount of a compound of formulae I(a)-I(d) or a pharmaceutically acceptable derivative thereof.
US08546385B2 Benzoic pyrrolopyridine derivatives
The present invention relates to compounds of formula: in which A, Cy, R1, R2, R3, R4, R5, R6, R7 and R8 are as defined in the description. The compounds of the invention are modulators of the NURR-1 nuclear receptors.
US08546384B2 Bonding tissues and cross-linking proteins with naphthalimide compounds
Naphthalimide compounds are used in tissue bonding and protein cross-linking applications. When activated by an activating agent, such as light in the 400-500 nm absorption range, the naphthalimide compounds form chemically-reactive species that cross-link proteins, bond connective tissues together, and bond tissues and other biomaterials together. A naphthalimide-labeled biomolecule, such as a naphthalimide-labeled chitosan, is also capable of bonding tissues without subsequent direct illumination of the contacted tissue area. The naphthalimide compounds may be used in tissue or arterial repair, stabilization of an expanded arterial wall after angioplasty, tethering pharmaceutical agents to tissue surfaces to provide local drug delivery, and for chemically bonding skin care products, sunscreens, and cosmetics to the skin.
US08546383B2 Chiral fused [1,2]imidazo[4,5-c] ring compounds
Fused [1,2]imidazo[4,5-c] ring compounds (e.g., imidazo[4,5-c]quinolines, 6,7,8,9-tetrahydroimidazo[4,5-c]quinolines, imidazo[4,5-c]naphthyridines, and 6,7,8,9-tetrahydroimidazo[4,5-c]naphthyridines) with a —CH(—X1—R1)— group in the fused ring at the 1-position of the imidazo ring, pharmaceutical compositions containing the compounds, intermediates, methods of making the compounds, and methods of use of these compounds as immunomodulators, for inducing cytokine biosynthesis in animals and in the treatment of diseases including viral and neoplastic diseases, are disclosed.
US08546382B2 Methods for enhancing hematopoietic progenitor cell engraftment
Described herein are methods for improving engraftment of hematopoietic cells in an individual following hematopoietic progenitor cell transplantation (e.g., via bone marrow or cord blood transplantation). Methods for increasing hematopoietic progenitor cell proliferation in individuals with bone marrow aplasia are also described. The methods involve administering an agent that inhibits adipogenesis, adipocyte growth, adipocyte differentiation and/or adipocyte proliferation.
US08546379B2 5HT2C receptor modulators
The present invention relates to novel compounds of Formula (I): which act as 5HT2C receptor modulators. These compounds are useful in pharmaceutical compositions whose use includes the treatment of obesity.
US08546377B2 Modulators of 5-HT receptors and methods of use thereof
The present application relates to 1,2,3,4,4a,5,6,7-octahydropyrazino[1,2-a][1,4]benzodiazepine, 1,2,3,4,4a,5,6,7-octahydropyrazino[1,2-a][1,5]benzodiazepine, 2,3,4,4a,5,6,7,11b-octahydro-1H-pyrido[3,4-d][2]benzazepine, 1,2,3,4,4a,5,6,7-octahydropyrazino[1,2-a][1]benzazepine, 1,2,3,4,4a,5-hexahydro-7H-pyrazino[1,2-a][4,1]benzoxazepine, and 2,3,4,4a,5,6-hexahydro-1H-pyrazino[2,1-d][1,5]benzoxazepine, and 5,6,7,7a,8,9,10,11-octahydropyrazino[1,2-d]pyrido[3,2-b][1,4]diazepine derivatives of formula (I) wherein R1, R2, R3, R4, R5, R6, X1, X2, X3, X4, Y1, Y2, and Y3 are as defined in the specification. The present application also relates to compositions comprising such compounds, and methods of treating disease conditions using such compounds and compositions, and methods for identifying such compounds.
US08546376B2 Pharmaceutical compounds
The invention relates to a series of compounds with particular activity as inhibitors of the serine-threonine kinase AKT. Also provided are pharmaceutical compositions comprising same as well as methods for treating cancer.
US08546373B2 Methods of sensitizing drug resistant microorganisms using methylsulfonylmethane (MSM)
Embodiments of the invention relate generally to formulations comprising methylsulfonylmethane (MSM) and one or more therapeutic agents, and uses of such formulations to treat, inhibit and/or sensitize infectious diseases. In several embodiments, such formulations are effective to treat, inhibit and/or sensitize drug-resistant bacterial microorganisms, for example, methicillin-resistant Staphylococcus aureus (MRSA).
US08546369B2 Salts of creatine imino sugar amides
The present invention relates to stable salts of creatine imino sugar amides and an inorganic or organic acid endowed with enhanced nutritional and/or therapeutical efficacy in respect to their individual effects and to solid compositions containing such salts, particularly suited to oral and parenteral administration. Methods of preparation and use of these compositions are also provided.
US08546368B2 Pyrazoloquinolones are potent PARP inhibitors
Compounds of Formula (I) inhibit the PARP enzyme and are useful for treating a disease or a disorder associated with PARP. Also disclosed are pharmaceutical compositions comprising compounds of Formula (I), methods of treatment comprising compounds of Formula (I), and methods of inhibiting the PARP enzyme comprising compounds of Formula (I).
US08546364B2 Stabilized steroid composition and method for its preparation
Stabilized, 17-substituted hydrocortisone containing compositions and methods of manufacture are disclosed. Isomerization of the hydrocortisone component of topical steroid compositions is markedly reduced by including an omega-6 acid component in the form of a free acid or as a compound such as an ester. Specifically disclosed are methods for preventing the isomerization of hydrocortisone 17-butyrate into hydrocortisone 21-butyrate through the use of safflower oil.
US08546363B2 Controlled release corticosteroid compositions and methods for the treatment of otic disorders
Disclosed herein are compositions and methods for the treatment of otic disorders with steroid, NSAID, and/or adenosine triphosphatase (“ATPase”) modulator agents. In these methods, the steroidal, NSAID, and/or ATPase compositions and formulations are administered locally to an individual afflicted with an otic disorder, through direct application of these compositions and formulations onto or via perfusion into the targeted auris structure(s).
US08546362B2 Medicinal cream made using neomycin sulphate, betamethasone valerate, and chitosan, and a process to make the same
The present invention is directed to a composition for treating bacterial skin infections & skin inflammation, along with skin rejuvenation. More particularly, the present invention relates to a pharmaceutical cream comprising a biopolymer, a corticosteroid and an antibacterial active ingredient. It discloses a composition for treating bacterial skin infections & skin inflammation, along with skin rejuvenation containing a) a biopolymer in the form of chitosan, b) a combination of active pharmaceutical ingredients (APIs), neomycin sulphate & betamethasone valerate used in treating bacterial skin infections & skin inflammations, c) a cream base containing primary and secondary emulsifiers, waxy materials, co-solvents, acids, preservatives, buffering agents, anti oxidants, chelating agents, and humectants and d) water. The active ingredients, namely chitosan, a corticosteroid Betamethasone Valerate, and an antibacterial agent Neomycin Sulphate, are incorporated in cream base for use in treating bacterial skin infections and skin inflammation due to allergy & itching, & wounds on human skin involving contacting human skin with the above identified composition.
US08546360B2 Method of treating citrus plants to reduce bacterial infections
A method of treating a citrus plant is provided to reduce the incidence of one or more insect-vectored bacterial infections such as citrus greening. The method comprises the step of applying a treatment composition one or more times to the plant, wherein the treatment composition comprises an effective amount of aluminum tris(O-ethyl phosphonate).
US08546359B2 Bicyclic aryl sphingosine 1-phosphate analogs
Compounds that have agonist activity at one or more of the SIP receptors are provided. The compounds are sphingosine analogs that, after phosphorylation, can behave as agonists at SIP receptors.
US08546357B2 Boron-containing small molecules for controlling ectoparasites
This invention provides novel compounds, methods of using the compounds, and pharmaceutical compositions containing the compounds.
US08546351B2 Hypersulfated disaccharide formulations
Hypersulfated disaccharides with utility in asthma or asthma related disorders are disclosed. The compounds are formulated with agents that enhance the oral delivery of the hypersulfated disaccharides. The delivery agents are selected from the group consisting of natural or synthetic polymers having ionic side chains as well as other compounds or types of compounds that improve the bioavailability of the disaccharides relative to delivery of the drug without such agents. The hypersulfated disaccharides are made from heparin or salts thereof.
US08546350B2 Oligomeric compounds and compositions for use in modulation of small non-coding RNAs
Compounds, compositions and methods are provided for modulating the expression and function of small non-coding RNAs. The compositions comprise oligomeric compounds, targeted to small non-coding RNAs. Methods of using these compounds for modulation of small non-coding RNAs as well as downstream targets of these RNAs and for diagnosis and treatment of disease associated with small non-coding RNAs are also provided.
US08546346B2 Methods to reprogram splice site selection in pre-messenger RNAs
The present invention relates to a method of modulating splice site selection, splicing and alternative, the method comprising the step of hybridizing an oligonucleotide-protein conjugate to a target pre-mRNA molecule in a cell or cell extract, wherein the oligonucleotide-protein conjugate comprises an oligonucleotide moiety which comprises at least two distinct sequence elements: (i) a nucleic acid sequence that is complementary to a specific region upstream of the splice site in the target pre-mRNA molecule; and (ii) an extension containing a protein binding site sequence element for covalently binding a protein; wherein the protein moiety comprises a protein capable of modulating splicing of the splice site upon binding with the protein binding site.
US08546345B2 Compositions and methods for siRNA inhibition of angiogenesis
RNA interference using small interfering RNAs which are specific for the vascular endothelial growth factor (VEGF) gene and the VEGF receptor genes Flt-1 and Flk-1/KDR inhibit expression of these genes. Diseases which involve angiogenesis stimulated by overexpression of VEGF, such as diabetic retinopathy, age related macular degeneration and many types of cancer, can be treated by administering the small interfering RNAs.
US08546342B2 Composition for treating mental health disorders
A composition of three compounds each selected from a selective re-uptake inhibitor of serotonin, a monoamine oxidase inhibitor, and a phosphodiesterase inhibitor, such that all three compounds are different and are naturally occurring.
US08546341B2 Compositions and methods for treating bruises
A composition for the treatment of bruising is disclosed. The composition can include an antioxidant, one or more citrus flavanoids, as active agents along with a pharmaceutically acceptable excipient or filler. The compositions are nutriceutical formulations having the capacity to reduce the number of bruises that occur over time and that reduce the healing time of bruises. The compositions are preferably in tablet form for oral consumption one or more times per day. A method of reducing bruising is also disclosed in which a patient in need of a treatment for bruising or at risk of developing bruises is identified. The composition can then be administered orally to the patient.
US08546340B2 Soothing pharmaceutical or cosmetic composition comprising a peptide that activates HMG-CoA reductase
A soothing cosmetic or pharmaceutical composition that includes at least one peptide that activates human HMG-CoA reductase general formula (I): R1-(AA)n-X1-Gly-Glu-Leu-Ser-X2-X3-(AAp-R2 in a physiologically suitable medium is disclosed. The invention further applies to a cosmetic treatment method intended to combat skin irritations. Additionally, methods of treating skin irritations with such a composition are described.
US08546339B2 Soothing cosmetic or pharmaceutical composition comprising a peptide which activates HMG-CoA reductase
Soothing cosmetic or pharmaceutical composition that includes at least one peptide as an active principle that activates human HMG-CoA reductase of general formula (I): R1-(AA)n-X1-Gly-Lys-X2-(AA)p-R2 and is chosen from among sequences SEQ ID NO: 1 to SEQ ID NO: 10, in a physiologically suitable medium is described. This novel peptide is designed to act as a soothing active principle capable of providing a solution to skin sensitivity in a cosmetic composition. The invention further applies to a cosmetic treatment method intended to combat skin irritations.
US08546336B2 SMAC peptidometics useful as IAP inhibitors
The present invention is directed to a compound of the formula: or pharmaceutically acceptable salts thereof and use of such compounds for treating proliferative diseases such as cancer, in mammals.
US08546333B2 Albumin fibers and fabrics and methods of generating and using same
Provided are method of generating a fiber from a globular protein such as albumin. Also provided are albumin fibers and fabrics and methods of using same for bonding a damaged tissue or for ex vivo or in vivo formation of a tissue.
US08546329B2 Erythropoietin solution preparation
The present invention relates to an erythropoietin-containing solution preparation containing a poloxamer and having a pH of 6.5 to 7.5. The present invention also relates to a method for quantifying a protein in a trace amount, the method including the following steps: binding a protein sample to a high-intensity fluorescent dye; separating a desired analyte from the obtained sample by an appropriate separation means; and quantifying the desired analyte and converting the amount of the analyte into the amount of the protein.
US08546325B2 Composition for improving membrane composition and functioning of cells
It has now been found that after administration to a diseased person or person that is at risk for developing such disease of a neutraceutical or pharmaceutical composition that comprises a) a lipid fraction comprising at least one of docosahexaneoic acid (DHA), docosapentaenoic acid (DPA) and eicosapentaenoic acid (EPA); b) a protein fraction comprising proteinaceous material from non-human origin which provide at least cysteine and/or taurine; and c) a mineral fraction comprising at least one of manganese and molybdene, the health of these persons improves. Membrane function of several types of mammalian cells improves, which allows efficient treatment of immune related disorders, such as allergy, autoimmune diseases, cancer, cognitive dysfunction and other diseases of the nervous system, neuropathies, such as diabetic neuropathies and neuropathic pains, neuronal damage during insulin resistance, and gut diseases and support of the development of gut and lung function during growth or recovery.
US08546324B2 Short-form human MD-2 as a negative regulator of toll-like receptor 4 signaling
The present invention is based on a novel, alternatively spliced human isoform of MD-2 (MD-2s). In addition, the present invention relates to modified MD-2 proteins, wherein one or more tyrosine residues have been mutated to phenylalanine. In various embodiments, the invention relates to methods and kits for preventing, reducing the likelihood of developing and/or treating various conditions using MD-2s. The invention also describes methods of determining the risk of a subject to various conditions.
US08546323B2 Thrombospondin-1 derived peptides and treatment methods
Treatments employing the matricellular protein thrombospondin-1 (TSP-I) and related compositions are disclosed for stabilizing atherosclerotic plaque and decreasing occurrence of plaque rupture events leading to, for example, myocardial infarction, stroke, and acute limb ischemia. Various peptides, including certain synthetic peptides, related to TSP-I are also disclosed. Such peptides have utility in stabilizing plaque in various contexts, including the disease states mentioned above. Some of these peptides include one or more sequences related to active sites of TSP-I for regulating, e.g., TGF-ss1 and MMP-9 activity. Experimental data show that a representative peptide provides a beneficial effect with systemic injection of the peptide.
US08546321B2 IL-4-derived peptides for modulation of the chronic inflammatory response and treatment of autoimmune diseases
The present invention relates to small peptides derived from a cytokine, interleukin-4 (IL-4), capable of binding to the IL-4 receptors and inhibiting macrophage activation, and thereby preventing the onset of inflammatory response. The invention further relates to use of said peptides for the production of a medicament for the treatment of different pathological conditions, wherein IL-4 plays a prominent role.
US08546320B2 Hsp9O-targeted anti-cancer chimeric peptide
Disclosed is a substance which is not accumulated stably in cells, does not cause the dysfunction of normal cells, and so on, and therefore can be used as an anti-cancer agent or in a DDS without having any adverse side effects. It is found that Hsp90 alone cannot exhibit its function as a chaperone in assisting the refolding of a protein such as survivin, but can exhibit this function when Hop (which is one of the partner proteins of Hsp90) binds to Hsp90. Thus, specifically disclosed herein is a chimeric peptide comprising of an Hsp90 TPR domain binding peptide and a cell-penetrating peptide.
US08546316B2 Liquid detergent composition with natural abrasive particles
The present invention relates to a dishwashing composition comprising abrasive particles and a suspending aid selected from the group consisting of crystalline wax structurants, micro-fibril-cellulose, amido-gellants, di-benzylidene polyol acetal derivatives, and mixtures thereof, and the process and use thereof.
US08546315B2 High quality bar soap incorporating triclinic talc
A personal cleansing composition includes soap at a concentration of at least 10 weight percent of the composition; and talc having a primarily triclinic crystal structure, the talc being included at a concentration of between 0.1 and 15 weight percent of the composition. A method for enhancing lathering properties of a bar soap includes the step of molding a bar soap from such a composition.
US08546314B2 Surface treatment compositions including polyquaternium-22 and sheilding salts
A surface treatment composition comprising from about 6% to about 20%, by weight of the composition, of cationic polymer; from about 6% to about 40%, by weight of the composition, of anionic surfactant; and from about 4% to about 15%, by weight of the composition, of a shielding salt, wherein the weight ratio of anionic surfactant to cationic polymer is between about 0.5:1 and about 4:1. The shielding salt is defined by having a molecular weight of from about 25 to about 500 and being incapable of lowering the surface tension of water below 50 mN/m when added to water at concentrations of up to 0.01M.
US08546312B2 Lubricant oil composition for internal combustion engine
The lubricating oil composition for an internal combustion engine of the invention comprises a lubricating base oil having a urea adduct value of not greater than 4% by mass and a viscosity index of 100 or greater, an ash-free antioxidant containing no sulfur as a constituent element, and at least one compound selected from among ash-free antioxidants containing sulfur as a constituent element and organic molybdenum compounds.
US08546310B2 Density-matched suspensions and associated methods
Of the many compositions and methods provided herein, an example method includes a method of treating a subterranean formation that comprises combining components comprising water and a density-matched suspension to prepare a treatment fluid, wherein the density-matched suspension comprises a suspending liquid and a solid particle suspended in the suspending liquid, and introducing the treatment fluid into a well bore. An example composition includes a suspension that comprises a suspending liquid comprising a hydrophobic liquid, wherein the hydrophobic liquid hydrolyzes when placed in contact with an aqueous fluid to form hydrophilic products, and a solid particle suspended in the suspending liquid, wherein the suspension is a density-matched suspension.
US08546309B2 Monomeric and polymeric linkers useful for conjugating biological molecules and other substances
The present invention concerns monomeric or polymeric linker molecules useful in biological and chemical applications, their synthesis, and the synthesis and use of derivatives of the linkers conjugated to a variety of detectable labels and other substances. The linkers may be used, for example, in conjunction with fluorescent labels, nucleic acid or nucleic acid analog probes, and solid phase systems, and to enhance the solubility of the conjugated molecules.
US08546307B2 Triple tag sequence and methods of use thereof
The present disclosure relates to novel triple tag sequences that may comprise a 6× histidine tag, a c-myc tag and a V5 tag. The present disclosure also provides polynucleotides, proteins, vectors and host cells that comprise the triple tag sequence of the present disclosure, including libraries of such polynucleotides, proteins, vectors and host cells. The novel triple tag sequences of the present disclosure may be used in phage display vectors and phage libraries and in methods for detection, screening, capture, purification, quantitation, and/or recovery of proteins of interest to which they are linked. Proteins of interest include antibodies such as single chain antibodies, single chain antibodies, and Fab fragments of antibodies or peptides such as non-antibody peptides.
US08546304B2 Composition and method for improving plant health
The present invention relates to plant-protecting active ingredient mixtures comprising, as active components, a neonicotinoid and one or two fungicides selected from pyraclostrobin and boscalid, in synergistically effective amounts and to a method of improving the health of plants by to the plants or the locus thereof by applying said mixtures.
US08546302B2 Forming resin substrates using dye sublimation and substrates formed using the same
Implementations of the present invention relate generally to methods, systems, and apparatus for manufacturing aesthetically pleasing, resin-based sheets including color and/or multi-decorated images. In particular, at least one implementation includes subjecting at least one surface of a polymer sheet to uniform heat and pressure in order to sublimate a dye into the surface, and ensure that that polymer sheet is not warped or otherwise damaged during processing. Additional implementations include decorative architectural resin panels including a resin sheet having a dye sublimated into one or more surfaces in order to create an effect of depth or other aesthetic.
US08546300B2 Thermosensitive recording material and image recording method
A thermosensitive recording material including: a support; an undercoat layer containing at least a water-soluble resin; a thermosensitive coloring layer containing a leuco dye and a developer; and a protective layer containing a water-soluble resin and a fluorescent whitening agent, wherein the undercoat layer, the thermosensitive coloring layer, and the protective layer are formed in this order over the support, wherein the undercoat layer has a single layer structure or a multilayer structure, and the protective layer has a single layer structure or a multilayer structure, and wherein the undercoat layer has an air permeance of 150 mL/min or less.
US08546293B2 Process for continuously producing geometric shaped catalyst bodies K
A process for producing geometric shaped catalyst bodies K whose active material is a multielement oxide which comprises the element Mo, the elements Bi and/or V and one or more of the elements Co, Ni, Fe, Cu and alkali metals, in which sources of the different elements are used to obtain a finely divided mixture which is coarsened to a powder by press agglomeration, the coarsened powder is used to form, by press agglomeration, shaped bodies V which are separated into undamaged shaped bodies V+ and into damaged shaped bodies V−, the undamaged shaped bodies V+ are converted by thermal treatment to the shaped catalyst bodies K, and the damaged shaped bodies V− are comminuted and recycled into the obtaining of the finely divided mixture.
US08546291B2 Cyclic compound, its metal complex and modified metal complex
A compound represented by formula (1): wherein Y1 to Y4 each independently represent any one of the following groups: in which Rα represents a hydrogen atom or a monovalent hydrocarbon group; P1 to P4 each independently represent a group of atoms necessary for forming a heterocyclic ring together with each of Y1 to Y4 and the two carbon atoms adjacent to each of Y1 to Y4, respectively; P5 and P6 each independently represent a group of atoms necessary for forming a cyclic skeleton together with the carbon atom to which Z1 bonds or Z2 bonds and the two carbon atoms adjacent to the carbon atom to which Z1 bonds or Z2 bonds; P1 and P2, P2 and P6, P6 and P4, P4 and P3, P3 and P5, and P5 and P1 may further combine with each other to form a ring; Q1 and Q2 each independently represent a connecting group or a direct binding; and Z1 and Z2 each independently represent any one of the following groups; —NRβ2, —ORβ, —SRβ, —PRβ2 in which Rβ represents a hydrogen atom or a monovalent hydrocarbon group, and when plural Rβs are present, these plural Rβs may be the same or different from each other.
US08546288B2 Substrate selection for a catalyst
In one embodiment, a method of forming a catalyst/substrate construction includes: identifying a catalyst having a specific activity, determining a surface area factor for supporting the catalyst based on the specific activity of the catalyst; selecting a substrate having the surface area factor; and applying the substrate to the catalyst to form the catalyst/substrate construction. In certain instances, the surface area factor may be determined according to the following equation: SA support ⁡ ( cm support 2 ⁢ / ⁢ cm planar 2 ) = [ “ Baseline ” ⁢ ( A ⁢ / ⁢ mg Pt ) × Mass ⁢ ⁢ Activity ⁢ ⁢ IF × Loading ⁢ ⁢ ( mg Pt ⁢ / ⁢ cm 2 ) ] [ Specific ⁢ ⁢ Activity ⁢ ⁢ ( μA ⁢ / ⁢ cm 2 ) × 0.000001 ⁢ ⁢ ( A ⁢ / ⁢ μA ) ] wherein the term “Baseline” refers to mass activity of 100 A per gram of platinum (Pt) for a comparative catalyst 5 nm Pt nano-particles dispersed on a carbon black support, the term “Mass Activity IF” refers to the activity required to achieve a high current density performance target of 1.5 A/cm2 at 0.67 V, at a platinum loading of 0.1 mg Pt/cm2.
US08546283B2 Substrate for EUVL optical member
The present invention relates to a substrate for EUV lithography optical member, comprising a silica glass containing TiO2, in which the substrate has two opposite surfaces, and the substrate has temperatures at which a coefficient of linear thermal expansion (CTE) is 0 ppb/° C. (Cross-Over Temperature: COT), and in which the two opposite surfaces have difference in the COTs of 5° C. or more.
US08546281B2 Glass plate with glass frit structure
A light emitting device includes: a first substrate; a second substrate; a light emitting unit interposed between the first substrate and the second substrate; and a sealing material bonding the first substrate to the second substrate and sealing the light emitting unit. The sealing material comprises V+4. In addition, a glass frit, a composition for forming a sealing material, and a method of manufacturing a light emitting device using the composition for forming a sealing material are provided to obtain the light emitting device. The sealing material of the light emitting device can be easily formed by coating and irradiation of electro-magnetic waves, so that manufacturing costs are low and deterioration of the light emitting unit occurring when sealing material is formed can be substantially prevented. The sealing material has good sealing properties and thus a light emitting device including the sealing material has a long lifetime.
US08546279B2 Cloth material for marking
A cloth material for marking including: a label cloth made of a white cloth formed of a fiber containing a component having affinity for a sublimation dye; an intermediate layer disposed on a rear surface of the label cloth, the intermediate layer including a synthetic resin which has affinity for the component of the label cloth and which has a melting point higher than a sublimation temperature of the sublimation dye; a transfer adhesive layer including a hot-melt thermoplastic synthetic resin and disposed on a surface of the intermediate layer; and a sheet of release paper disposed on a surface of the transfer adhesive layer. The intermediate layer is formed and closely fixed on the rear surface of the label cloth by laminating or coating. The transfer adhesive layer is also formed by laminating or coating. Desired colors, patterns and/or figures are transferable from transfer paper printed with a sublimation dye onto a surface of the cloth material for marking that has a transfer adhesive layer on its rear surface.
US08546277B2 Heating plastics via infrared radiation
Process for heating a plastic by means of at least one source of electromagnetic radiation, characterized in that the electromagnetic radiation is emitted in the infrared at a wavelength or in a wavelength spectrum contained in one of the following ranges: 1110-1160 nm; 1390-1450 nm; 1610-1650 nm; 1675-1700 nm; 1880-2100 nm; 2170-2230 nm.
US08546268B2 Manufacturing integrated circuit components having multiple gate oxidations
STI divot formation is minimized and STI field height mismatch between different regions is eliminated. A nitride cover layer (150) having a thickness less than 150 then a oxide cover layer (160) having a thickness less than 150 is deposited acting as implant buffer after pad oxide removal following the STI CMP process. This nitride or oxide stack is selectively removed by masking prior to gate oxidation of each LV (low voltage) region (GX1), MV (intermediate voltage) region (GX3) and HV (high voltage) region (GX5) respectively followed by a gate poly deposition.
US08546267B2 Method of processing a workpiece in a plasma reactor using multiple zone feed forward thermal control
A method of controlling wafer temperature in a plasma reactor by obtaining the next scheduled change in RF heat load on the workpiece, and using thermal modeling to estimate respective changes in wafer backside gas pressure and in coolant flow through a wafer support pedestal that would compensate for the next scheduled change in RF heat load, and making the respective changes in the backside gas pressure or in the coolant flow prior to the time of the next scheduled change.
US08546264B2 Etching radical controlled gas chopped deep reactive ion etching
A method for silicon micromachining techniques based on high aspect ratio reactive ion etching with gas chopping has been developed capable of producing essentially scallop-free, smooth, sidewall surfaces. The method uses precisely controlled, alternated (or chopped) gas flow of the etching and deposition gas precursors to produce a controllable sidewall passivation capable of high anisotropy. The dynamic control of sidewall passivation is achieved by carefully controlling fluorine radical presence with moderator gasses, such as CH4 and controlling the passivation rate and stoichiometry using a CF2 source. In this manner, sidewall polymer deposition thicknesses are very well controlled, reducing sidewall ripples to very small levels. By combining inductively coupled plasmas with controlled fluorocarbon chemistry, good control of vertical structures with very low sidewall roughness may be produced. Results show silicon features with an aspect ratio of 20:1 for 10 nm features with applicability to nano-applications in the sub-50 nm regime. By comparison, previous traditional gas chopping techniques have produced rippled or scalloped sidewalls in a range of 50 to 100 nm roughness.
US08546254B2 Mechanisms for forming copper pillar bumps using patterned anodes
The mechanisms of preparing bump structures described by using patterned anodes may simplify bump-making process, reduce manufacturing cost, and improve thickness uniformity within die and across the wafer. In addition, the mechanisms described above allow forming bumps with different heights to allow bumps to be integrated with elements on a substrate with different heights. Bumps with different heights expand the application of copper post bumps to enable further chip integration.
US08546253B1 Self-aligned polymer passivation/aluminum pad
The invention provides a semiconductor chip structure having at least one aluminum pad structure and a polyimide buffering layer under the aluminum pad structure, wherein the polyimide buffering layer is self-aligned to the aluminum pad structure, and a method of forming the same. The method includes forming a polyimide buffering layer on a substrate, forming an aluminum pad structure on the buffering layer, and, using the aluminum pad structure as a mask, etching the substrate to remove the polyimide buffering layer from the substrate everywhere except under the aluminum pad structure.
US08546251B1 Compact read only memory cell
A method of manufacturing a read only memory cell includes connecting electrically a drain of the transistor to the bit line with a first conductor and a via. The method also includes generating a logic zero at a source of the transistor by electrically connecting the source of the transistor to a ground line with the first conductor. Further, the method includes, programming the read only memory cell to logic zero. A method of manufacturing a read only memory cell includes connecting electrically a drain of the transistor to the bit line with a first conductor and a via. The method also includes, connecting electrically a source of the transistor to the drain with the first conductor. Further, the method includes programming the read only memory cell to logic one.
US08546250B2 Method of fabricating vertical integrated semiconductor device with multiple continuous single crystal silicon layers vertically separated from one another
A vertically integrated semiconductor device includes multiple continuous single crystal silicon layers vertically separated from one another by a dielectric layer or layers. Semiconductor devices are disposed on an underlying single crystal silicon substrate and the continuous single crystal silicon layers. The individual devices are interconnected to one another using tungsten or doped polysilicon leads that extend through openings formed in the continuous single crystal silicon layers. The method for forming the structure includes forming a dielectric material over the single crystal silicon layer or substrate and forming an opening extending down to the surface of the single crystal silicon material to act as a seed layer. An epitaxial silicon growth process begins at the seed location and laterally overgrows the openings. Growth fronts from the various seed locations meet to form a continuous single crystal silicon layer which is then polished.
US08546249B2 Selective growth of polycrystalline silicon-containing semiconductor material on a silicon-containing semiconductor surface
A method of depositing polycrystalline silicon exclusively on monocrystalline first silicon surface portions of a substrate surface which besides the first surface portions additionally has insulator surface portions, comprising the steps of depositing boron on the first silicon surface portions in an amount which in relation to the first silicon surface portions respectively corresponds to more than a monolayer of boron, and depositing silicon on the first silicon surface portions treated in that way.
US08546245B2 Method for manufacturing composite substrate comprising wide bandgap semiconductor layer
Provided is a method for manufacturing a low-cost bonded wafer (8) which allows bulk crystals of a wide bandgap semiconductor (1) to be transferred onto a handle substrate (3) as thinly as possible without breaking the substrate. More specifically, provided is a method for manufacturing a bonded wafer (8) by forming a wide bandgap semiconductor film (4) on a surface of a handle substrate (3), the method comprising a step of implanting ions from a surface (5) of a wide bandgap semiconductor substrate (1) having a bandgap of 2.8 eV or more to form an ion-implanted layer (2), a step of applying a surface activation treatment to at least one of the surface of the handle substrate (3) and the ion-implanted surface (5) of the wide bandgap semiconductor substrate (1), a step of bonding the surface (5) of the wide bandgap semiconductor substrate (1) and the surface of the handle substrate (3) to obtain bonded substrates (6), a step of applying a heat treatment to the bonded substrates (6) at a temperature of 150° C. or more and 400° C. less, and a step of subjecting the ion-implanted layer (2) of the wide bandgap semiconductor substrate (1) to irradiation of visible light from the semiconductor substrate (1) side of the bonded substrates (6) to embrittle an interface of the ion-implanted layer (2) and transfer the wide bandgap semiconductor film (4) onto the handle substrate (3).
US08546239B2 Methods of fabricating non-volatile memory with air gaps
Air gap isolation in non-volatile memory arrays and related fabrication processes are provided. Electrical isolation can be provided, at least in part, by bit line air gaps that are elongated in a column direction and/or word line air gaps that are elongated in a row direction. The bit line air gaps may be formed in the substrate, extending between adjacent active areas of the substrate, as well as above the substrate surface, extending between adjacent columns of non-volatile storage elements. The word line air gaps may be formed above the substrate surface, extending between adjacent rows of non-volatile storage elements.
US08546230B2 Bipolar transistor with a collector having a protected outer edge portion for reduced based-collector junction capacitance and a method of forming the transistor
Disclosed are embodiments of a transistor (e.g., bipolar junction transistor (BJT) or a heterojunction bipolar transistor (HBT)) and a method of forming the transistor with a collector region having a protected upper edge portion for reduced base-collector junction capacitance Cbc. In the embodiments, a collector region is positioned laterally adjacent to a trench isolation region within a substrate. Mask layer(s) cover the trench isolation region and further extend laterally onto the edge portion of the collector region. A first section of an intrinsic base layer is positioned above a center portion of the collector region and a second section of the intrinsic base layer is positioned above the mask layer(s). During processing these mask layer(s) prevent divot formation in the upper corner of the trench isolation region at the isolation region-collector region interface and further limit dopant diffusion from a subsequently formed raised extrinsic base layer into the collector region.
US08546228B2 Strained thin body CMOS device having vertically raised source/drain stressors with single spacer
A method of forming a transistor device includes forming a patterned gate structure over a semiconductor substrate; forming a spacer layer over the semiconductor substrate and patterned gate structure; removing horizontally disposed portions of the spacer layer so as to form a vertical sidewall spacer adjacent the patterned gate structure; and forming a raised source/drain (RSD) structure over the semiconductor substrate and adjacent the vertical sidewall spacer, wherein the RSD structure has a substantially vertical sidewall profile so as to abut the vertical sidewall spacer and produce one of a compressive and a tensile strain on a channel region of the semiconductor substrate below the patterned gate structure.
US08546227B2 Contact for high-K metal gate device
A method of making an integrated circuit includes providing a substrate with a high-k dielectric and providing a polysilicon gate structure over the high-k dielectric. A doping process is performed on the substrate adjacent to the polysilicon gate structure, after which the polysilicon gate structure is removed and replaced with a metal gate structure. An interlayer dielectric (ILD) is deposited over the metal gate structure and the doped substrate, and a dry etch process forms a trench in the ILD to a top surface of the metal gate structure. After the dry etch process, a wet etch process forms an undercut near the top surface of the metal gate structure. The trench and undercut are then filled with a conductive material.
US08546226B2 SONOS non-volatile memory cell and fabricating method thereof
A method for fabricating a silicon-oxide-nitride-oxide-silicon (SONOS) non-volatile memory cell, wherein the method comprises steps as following: a pad oxide layer and a first hard mask layer are sequentially formed on a substrate. The pad oxide layer and the first hard mask layer are then etched through to form an opening exposing a portion of the substrate. Subsequently, an oxide-nitride-oxide (ONO) structure with a size substantially less than or equal to the opening is formed to coincide with the portion of the substrate exposed from the opening.
US08546220B1 Method for fabricating buried bit lines
A method for fabricating buried bit lines comprises steps of: defining a plurality of parallel masked regions and a plurality of first etched regions each forming between any two neighboring masked regions on a surface of a substrate, and wherein the masked region is wider than the first etched region; etching the first etched regions to form a plurality of first trenches and a plurality of first pillars; forming two bit lines respectively on two sidewalls of each first trench; etching the first pillars to form a plurality of second pillars corresponding to the bit lines. The present invention uses a two-stage etching process to prevent pillars from bending or collapsing due to high aspect ratio. Moreover, the present invention has a simple process and is able to reduce cost and decrease cell size.
US08546214B2 P-type control gate in non-volatile storage and methods for forming same
Non-voltage storage and techniques for fabricating non-volatile storage are disclosed. In some embodiments, at least a portion of the control gates of non-volatile storage elements are formed from p-type polysilicon. In one embodiment, a lower portion of the control gate is p-type polysilicon. The upper portion of the control gate could be p-type polysilicon, n-type polysilicon, metal, metal nitride, etc. P-type polysilicon in the control gate may not deplete even at high Vpgm. Therefore, a number of problems that could occur if the control gate depleted are mitigated. For example, a memory cell having a control gate that is at least partially p-type polysilicon might be programmed with a lower Vpgm than a memory cell formed from n-type polysilicon.
US08546210B2 Semiconductor device and method for manufacturing the same
It is an object of the present invention to provide a method of separating a thin film transistor, and circuit or a semiconductor device including the thin film transistor from a substrate by a method different from that disclosed in the patent document 1 and transposing the thin film transistor, and the circuit or the semiconductor device to a substrate having flexibility. According to the present invention, a large opening or a plurality of openings is formed at an insulating film, a conductive film connected to a thin film transistor is formed at the opening, and a peeling layer is removed, then, a layer having the thin film transistor is transposed to a substrate provided with a conductive film or the like. A thin film transistor according to the present invention has a semiconductor film which is crystallized by laser irradiation and prevents a peeling layer from exposing at laser irradiation not to be irradiated with laser light.
US08546209B1 Replacement metal gate processing with reduced interlevel dielectric layer etch rate
A method of forming a semiconductor device structure includes forming an interlevel dielectric (ILD) layer over a semiconductor substrate and a dummy transistor gate structure formed on the substrate; infusing a shallow gas cluster ion beam (GCIB) layer in a top portion of the ILD layer; and removing at least one layer from the dummy transistor gate structure, wherein the at least one layer comprises a same material as the ILD layer and wherein the GCIB layer has a slower etch rate with respect to the ILD layer.
US08546202B2 Manufacturing method for semiconductor structures
A manufacturing method for semiconductor structures includes providing a substrate having a first region and a second region defined thereon, forming a plurality of first patterns in the first region and at least a second pattern in the second region, forming a plurality of first spacers respectively on sidewalls of the first patterns and at least a second spacer on a sidewall of the second pattern, forming a patterned protecting layer in the second region, removing the first patterns from the first region to form a plurality of first masking patterns in the first region and at least a second masking pattern in the second region, and transferring the first masking patterns and the second masking pattern to the substrate.
US08546200B2 Thin film semiconductor device, display device using such thin film semiconductor device and manufacturing method thereof
A thin film semiconductor device formed as integrated circuits on an insulating substrate with bottom gate type thin film transistors stacked with gate electrodes, a gate insulating film and a semiconductor thin film in the order from below upward. The gate electrodes comprise metallic materials with thickness less than 100 nm. The gate insulating film has a thickness thicker than the gate electrodes. The semiconductor thin film comprises polycrystalline silicon crystallized by a laser beam. By reducing thickness of metallic gate electrodes, thermal capacity becomes small and difference in thermal condition on the metallic gate electrodes and on the insulating substrate made of glass or the like becomes small. This invention relates to the task of uniforming and optimizing recrystallization by a laser anneal treatment provided for the semiconductor thin film which works as an active layer of the bottom gate type thin film transistors.
US08546199B2 Method of manufacturing transparent transistor with multi-layered structures
A method of manufacturing a transparent transistor including a substrate, source and drain electrodes formed on the substrate, each having a multi-layered structure of a lower transparent layer, a metal layer and an upper transparent layer, a channel formed between the source and drain electrodes, and a gate electrode aligned with the channel. The lower transparent layer or the upper transparent layer is formed of a transparent semiconductor layer, which is the same as the channel.
US08546195B2 Semiconductor package having semiconductor die with internal vertical interconnect structure and method therefor
A semiconductor wafer is made by forming a first conductive layer over a sacrificial substrate, mounting a semiconductor die to the sacrificial substrate, depositing an insulating layer over the semiconductor die and first conductive layer, exposing the first conductive layer and contact pad on the semiconductor die, forming a second conductive layer over the insulating layer between the first conductive layer and contact pad, forming solder bumps on the second conductive layer, depositing an encapsulant over the semiconductor die, first conductive layer, and interconnect structure, and removing the sacrificial substrate after forming the encapsulant to expose the conductive layer and semiconductor die. A portion of the encapsulant is removed to expose a portion of the solder bumps. The solder bumps are sized so that each extends the same outside the encapsulant. The semiconductor die are stacked by electrically connecting the solder bumps.
US08546194B2 Integrated circuit packaging system with interconnects and method of manufacture thereof
A method of manufacture of an integrated circuit packaging system includes: providing a base carrier; forming a conductive post on the base carrier, the conductive post having a top protrusion with a protrusion top side; mounting a base integrated circuit over the base carrier; and forming a base encapsulation over the base integrated circuit, the base encapsulation having an encapsulation top side and an encapsulation recess with the conductive post partially exposed within the encapsulation recess, the encapsulation top side above the protrusion top side.
US08546193B2 Semiconductor device and method of forming penetrable film encapsulant around semiconductor die and interconnect structure
A semiconductor device has a plurality of bumps formed over a carrier. A semiconductor die is mounted to the carrier between the bumps. A penetrable film encapsulant layer having a base layer, first adhesive layer, and second adhesive layer is placed over the semiconductor die and bumps. The penetrable film encapsulant layer is pressed over the semiconductor die and bumps to embed the semiconductor die and bumps within the first and second adhesive layers. The first adhesive layer and second adhesive layer are separated to remove the base layer and first adhesive layer and leave the second adhesive layer around the semiconductor die and bumps. The bumps are exposed from the second adhesive layer. The carrier is removed. An interconnect structure is formed over the semiconductor die and second adhesive layer. A conductive layer is formed over the second adhesive layer electrically connected to the bumps.
US08546184B2 Package substrate having die pad with outer raised portion and interior recessed portion
A method of forming an electronic assembly includes dispensing a die attach material on a substrate into a recessed portion that includes an inner recessed portion of including a die pad. The die attach material is not dispensed on an outer raised flat portion of the die pad. A semiconductor die is attached directly on the outer raised flat portion and affixed to the die pad with said die attach material in said interior recessed portion but not on said outer raised flat portion.
US08546180B2 Method for manufacturing oxide semiconductor device
An object is to provide a semiconductor device having a structure with which parasitic capacitance between wirings can be sufficiently reduced. An oxide insulating layer serving as a channel protective layer is formed over part of an oxide semiconductor layer overlapping with a gate electrode layer. In the same step as formation of the oxide insulating layer, an oxide insulating layer covering a peripheral portion of the oxide semiconductor layer is formed. The oxide insulating layer which covers the peripheral portion of the oxide semiconductor layer is provided to increase the distance between the gate electrode layer and a wiring layer formed above or in the periphery of the gate electrode layer, whereby parasitic capacitance is reduced.
US08546178B2 Semiconductor light emitting device and method for manufacturing semiconductor light emitting device
According to one embodiment, a semiconductor light emitting device includes a substrate, a first semiconductor layer, a light emitting layer, a second semiconductor layer, and a translucent electrode. The substrate includes a first region provided along periphery of a first major surface and a second region provided on center side of the first major surface as viewed from the first region. The first semiconductor layer is provided on the first major surface of the substrate. The light emitting layer is provided on the first semiconductor layer. The second semiconductor layer is provided on the light emitting layer. The translucent electrode is provided on the second semiconductor layer. A reflectance in the second region is higher than a reflectance in the first region.
US08546177B2 Methods of manufacturing phase-change memory device and semiconductor device
Methods of manufacturing a phase-change memory device and a semiconductor device are provided. The method of manufacturing the phase-change memory device includes forming a switching device layer, an ohmic contact layer, and a hard mask layer on a semiconductor substrate, patterning the hard mask layer to form a hard mask pattern, etching the ohmic layer and the switching layer using the hard mask pattern to form a pattern structure including an ohmic contact pattern, a switching device pattern, and the hard mask pattern, selectively oxidizing a surface of the pattern structure, forming an insulating layer to bury the pattern structure, and selectively removing the hard mask pattern other than the oxidized surface thereof to form a contact hole.
US08546176B2 Forming chalcogenide semiconductor absorbers
Sulfur-containing chalcogenide absorbers in thin film solar cell are manufactured by sequential sputtering or co-sputtering targets, one of which contains a sulfur compound, onto a substrate and then annealing the substrate. The anneal is performed in a non-sulfur containing environment and avoids the use of hazardous hydrogen sulfide gas. A sulfurized chalcogenide is formed having a sulfur concentration gradient.
US08546172B2 Laser polishing of a back contact of a solar cell
Provided herein are methods of polishing, cleaning and texturing back contacts of thin-film solar cells. According to various embodiments, the methods involve irradiating sites on the back contact with laser beams to remove contaminants and/or smooth the surface of the back contact. The back contact, e.g., a molybdenum, copper, or niobium thin-film, is smoothed prior to deposition of the absorber and other thin-films of the photovoltaic stack. In certain embodiments, laser polishing of the back contact is used to enhance the diffusion barrier characteristics of the back contact layer, with all or a surface layer of the back contact becoming essentially amorphous. In certain embodiments, the adhesion of the absorber layer is enhanced by the textured back contact and by the presence of the amorphous metal at the deposition surface.
US08546171B2 Method of fabricating thin film solar cell
Disclosed is a method of fabricating a thin film solar cell. A separation process (‘P4’ process) of insulating a thin film solar cell from the outside is integrally performed with a transparent electrode patterning process (‘P1’ process) and a metallic electrode patterning process (‘P3’ process). This may reduce the fabrication costs and enhance spatial efficiency as the ‘P4’ process and equipment for the ‘P4’ process are not required.
US08546170B2 MEMS process and device
A method of fabricating a micro-electrical-mechanical system (MEMS) transducer comprises the steps of forming a membrane (5) on a substrate (3), and forming a back-volume in the substrate. The step of forming a back-volume in the substrate comprises the steps of forming a first back-volume portion (7a) and a second back-volume portion (7b), the first back-volume portion (7a) being separated from the second back-volume portion (7b) by a step in a sidewall of the back-volume. The cross-sectional area of the second back-volume portion (7b) can be made greater than the cross-sectional area of the membrane (5), thereby enabling the back-volume to be increased without being constrained by the cross-sectional area of the membrane (5). The back-volume may comprise a third back-volume portion. The third back-volume portion enables the effective diameter of the membrane to be formed more accurately.
US08546168B2 Method and apparatus for detecting nucleotides
A system and method employing at least one semiconductor device, or an arrangement of insulating and metal layers, having at least one detecting region which can include, for example, a recess or opening therein, for detecting a charge representative of a component of a polymer, such as a nucleic acid strand proximate to the detecting region, and a method for manufacturing such a semiconductor device. The system and method can thus be used for sequencing individual nucleotides or bases of ribonucleic acid (RNA) or deoxyribonucleic acid (DNA). The semiconductor device includes at least two doped regions, such as two n-typed regions implanted in a p-typed semiconductor layer or two p-typed regions implanted in an n-typed semiconductor layer. The detecting region permits a current to pass between the two doped regions in response to the presence of the component of the polymer.
US08546166B2 III nitride crystal substrate, and light-emitting device and method of its manufacture
Toward making available III nitride crystal substrates advantageously employed in light-emitting devices, and light-emitting devices incorporating the substrates and methods of manufacturing the light-emitting devices, a III nitride crystal substrate has a major face whose surface area is not less than 10 cm2 and, in a major-face principal region excluding the peripheral margin of the major face from its outer periphery to a 5 mm separation from its outer periphery, the total dislocation density is from 1×104 cm−2 to 3×106 cm−2, and the ratio of screw-dislocation density to the total dislocation density is 0.5 or greater.
US08546161B2 Manufacturing method of thin film transistor and liquid crystal display device
Etching of a semiconductor layer including a part over a gate wiring and formation of a contact hole for connection between a pixel electrode and a drain electrode are performed by one-time photolithography step and one-time etching step; thus, the number of photolithography steps is reduced. The exposed part of the gate wiring is covered by an insulating layer, and this insulating layer also functions as a spacer for maintaining a space for a liquid crystal layer. By the reduction in the number of photolithography steps, a liquid crystal display device can be provided at lower cost and higher productivity. Using an oxide semiconductor for the semiconductor layer can realize a liquid crystal display device with low power consumption and high reliability.
US08546159B2 Phosphor film, method of forming the same, and method of coating phosphor layer on LED chips
Phosphor films, methods of forming the phosphor films, and methods of coating a phosphor layer on light-emitting chips are disclosed. The phosphor film includes: a base film; a phosphor layer that is formed on the base film and comprises an incompletely cured resin material and phosphor particles mixed with the incompletely cured resin material; and a cover film that is formed on the phosphor layer and protects the phosphor layer.
US08546157B2 Bifacial solar cell using ion implantation
An improved bifacial solar cell is disclosed. In some embodiments, the front side includes an n-type field surface field, while the back side includes a p-type emitter. In other embodiments, the p-type emitter is on the front side. To maximize the diffusion of majority carriers and lower the series resistance between the contact and the substrate, the regions beneath the metal contacts are more heavily doped. Thus, regions of higher dopant concentration are created in at least one of the FSF or the emitter. These regions are created through the use of selective implants, which can be performed on one or two sides of the bifacial solar cell to improve efficiency.
US08546154B2 Apparatus and method to inspect defect of semiconductor device
An apparatus and method to inspect a defect of a substrate. Since a recess of an under layer of a substrate is darker than a projection of a top layer, a ratio of a value of a secondary electron signal (of an SEM) of the under layer to a value of the top layer may be increased to improve a pattern image used to inspect an under layer defect. Several conditions under which electron beams are irradiated may be set, and the pattern may be scanned under such conditions. Secondary electron signals may be generated according to the conditions and converted into image data to display various pattern images. Scan information on the images may be stored with positional information on the substrate. Each of scan information on the pattern images may be calculated to generate a new integrated image.
US08546152B2 Enhanced endpoint detection in non-volatile memory fabrication processes
A method of fabricating non-volatile memory is provided for memory cells employing a charge storage element with multiple charge storage regions. A first charge storage layer is formed over a tunnel dielectric layer at both a memory array region and an endpoint region of a semiconductor substrate. The first charge storage layer is removed from the endpoint region to expose the tunnel dielectric region. A second charge storage layer is formed over the first charge storage layer at the memory array region and over the tunnel dielectric layer at the endpoint region. When etching the second charge storage layer to form the stem regions of the memory cells, the tunnel dielectric layer provides a detectable endpoint signal to indicate that etching for the second charge storage layer is complete.
US08546151B2 Method for manufacturing magnetic storage device and magnetic storage device
Disclosed is a method for manufacturing a magnetic storage device comprising a TMR element, which comprises a step for forming an insulting film on an interlayer insulating film provided with a wiring layer, an opening formation step for forming an opening in the insulating film so that the wiring layer is exposed therefrom, a metal layer formation step for forming a metal layer on the insulating layer so that the opening is filled therewith, a CMP step for polishing and removing the metal layer on the insulating layer by a CMP method and forming the metal layer remaining in the opening into a lower electrode, and a step for forming a TMR element on the lower electrode. Also disclosed is a magnetic storage device comprising an interlayer insulating film provided with a wiring layer, an insulating film formed on the interlayer insulating film, an opening formed in the insulating film so that the wiring layer is exposed therefrom, a barrier metal layer provided so as to cover the inner surface of the opening, a lower electrode formed on the barrier metal so as to fill the opening, and a TMR element formed on the lower electrode.
US08546146B2 Process for evaluating a refinery feedstock
Process for evaluating a plurality of refinery feedstocks, by providing an array of refinery feedstocks, the array having at least a plurality of different refinery feedstocks, and fractionating each of the refinery feedstocks in the array, either in parallel or in a rapid serial fashion, to produce a further array having a plurality of fractions with different chemical and/or physical properties, each fraction being representative of a process stream that might be present in a refinery. Each of the plurality of fractions is analyzed to determine one or more chemical and/or physical properties of the fractions, the analyzes being performed at least partially in parallel.
US08546145B2 Fast screening of clones
The invention relates to a method of fast identification and isolation of cells featuring a desired phenotype. The phenotype is coupled to the amount of gas-liberating enzymes or increased growth. The cells are encapsulated into microcapsules allowing exchange of solvents through the microcapsule wall, but retaining some or all of the gas formed by gas-liberating enzymes on contact with corresponding substrates. Microcapsules containing increased amounts of gas-liberating enzymes are starting to float and can be separated. The cells are then isolated from the microcapsules according to standard procedures.
US08546140B2 Methods for the production of iPS cells using non-viral approach
Methods and composition of induction of pluripotent stem cells and other desired cell types are disclosed. For example, in certain aspects methods for generating essentially vector-free induced pluripotent stem cells are described. Furthermore, the invention provides induced pluripotent stem cells and desired cell types essentially free of exogenous vector elements with the episomal expression vectors to express differentiation programming factors.
US08546135B2 In vivo genome-wide mutagenesis
Disclosed herein are compositions and methods for deleting or duplicating DNA in a mammalian genome. Also disclosed are compositions and methods for generating a random genome-wide chromosome rearrangement. Also disclosed are compositions and methods for streamlined construction of gene targeting vectors.
US08546134B2 Method for isolating nuclei
This invention relates to methods of isolating cell nuclei from the other cell components in cell samples, e.g., cell samples from cell cultures or tissue samples. The method does not comprise ultracentrifugation or super-centrifugation rather the method comprises centrifuging cell samples in a table-top conventional centrifuge or microfuge. The method also comprises the use of buffers that are substantially devoid of protease inhibitor or enzyme treatments. The methods facilitate separation of nuclei from nuclear outer membranes leaving the cellular structures and inner membranes of nuclei intact. The method also provides for rapid and consistent results.
US08546130B2 Oligomer probe array with improved signal-to-noise ratio fabrication method thereof
An oligomer probe array with improved signal-to-noise ratio includes a substrate, a plurality of probe cell active regions formed on or in the substrate, with each of the plurality of probe cell active regions having a substantially planar surface and being coupled with at least one oligomer probe with own sequence, and a probe cell isolation region defining the probe cell active regions and having no functional groups for coupling with the oligomer probes on a surface.
US08546124B2 Infectious clones of RNA viruses and vaccines and diagnostic assays derived thereof
An infectious clone based on the genome of a wild-type RNA virus is produced by the process of providing a host cell not susceptible to infection by the wild-type RNA virus, providing a recombinant nucleic acid based on the genome of the wild-type RNA virus, transfecting the host cell with the recombinant nucleic acid and selecting for infectious clones. The recombinant nucleic acid comprises at least one full-length DNA copy or in vitro-transcribed RNA copy or a derivative of either. The infectious clones can be used in single or dual purpose vaccines and in viral vector vaccines.
US08546116B2 Method for fractionating lignocellulose-based biomass
A method and apparatus for fractionating a lignocellulose-based biomass are provided. The method includes providing a lignocellulose-based biomass, extracting lignin from the biomass by adding a first solvent capable of dissolving the lignin, extracting xylose by adding a second solvent capable of dissolving hemicellulose to the biomass treated with the first solvent, and extracting the cellulose remaining in the biomass. In this method, a continuous process can be performed instead of a low efficiency batch-type process and components of the biomass can be obtained at high yield.
US08546114B2 Processes for the preparation of optically active cyclopentenones and cyclopentenones prepared therefrom
The present invention relates to novel processes for preparing optically active Cyclopentenones of Formula (R)-1, which are useful for the preparation of Prostaglandins and analogs thereof. The invention also relates to novel Cyclopentenones prepared from the processes.
US08546099B2 Processes for preparing a dough or a baked product using maltogenic alpha-amylase variants
The inventors have modified the amino acid sequence of a maltogenic alpha-amylase to obtain variants with improved properties, based on the three-dimensional structure of the maltogenic alpha-amylase Novamyl. The variants have altered physicochemical properties, e.g. an altered pH optimum, improved thermostability, increased specific activity, an altered cleavage pattern or an increased ability to reduce retrogradation of starch or staling of bread.
US08546098B2 Biomarkers for monitoring insulin resistance and methods using the same
Biomarkers relating to insulin resistance are provided, as well as methods for using such biomarkers as biomarkers for insulin resistance. These biomarkers may be used to monitor the progression or regression of insulin resistance or to monitor the efficacy of insulin resistance treatment. Also provided are suites of small molecule entities as biomarkers for insulin resistance.
US08546094B2 Ubiquitin ligase and use thereof
Provided is a novel ubiquitin ligase which has linear polyubiquitination activity and can be efficiently expressed and purified. It was found out that a complex of (a) a protein having a part of HOIP and at least having a UBA region and a RING-IBR-RING region thereof, and (b) One or more kinds of proteins which individually form a complex with the above (a) is a novel ubiquitin ligase which has linear polyubiquitination activity and can be efficiently expressed and purified.
US08546089B2 CMYBP-C and MLC2 as diagnostic markers of cardiac injury
The invention relates to markers for acute myocardial infarction (AMI), particularly markers that may be used in the rapid and accurate diagnosis of AMI or reinfarction. A method of diagnosing cardiac injury comprising identifying an elevated concentration of cardiac myosin binding protein C (cMyBP-C) or a fragment thereof or myosin regulatory light chain 2 (MLC2) or a fragment thereof in a sample obtained from a subject.
US08546086B2 Use of neuregulin-β as an indicator and/or target
The invention relates, inter alia, to the use of neuregulin-β as an indicator in a method for detecting a neuronal process. The invention furthermore relates to the use of neuregulins, preferably a neuregulin isoform having an isoelectric point in the range from pH 4.3 to 5.0, as a target for detecting and/or exerting an influence on neuronal processes, in particular for exerting an influence on long-term memory. Neuregulins, in particular neuregulin-β and also substances which exert an influence on the status, i.e. the expression and/or post-translational modification, of neuregulin-β, can therefore be used as agents for controlling the course of, treating and/or alleviating neuronal diseases, e.g. Alzheimer's disease.
US08546085B2 Methods of identifying modulators of the bitter taste receptor TAS2R44
Steviol glycosides have been discovered to bind the bitter taste receptor TAS2R44. Novel methods of identifying modulators and in particular inhibitors to the bitter taste of steviol glycosides and an inhibitor of steviol glycosides are provided.
US08546083B2 Molecular accessibility assay
Methods and compositions are provided for determining polypeptide-nucleic acid interactions.
US08546082B2 Methods for identification of sepsis-causing bacteria
The present invention provides compositions, kits and methods for rapid identification and quantification of sepsis-causing bacteria by molecular mass and base composition analysis.
US08546080B2 Molecular dispensers
A method for dispensing charged particles includes applying a bias voltage to promote motion of charged molecules through a nanopore, detecting passage of at least one charged molecule through the nanopore, and manipulating an electrostatic potential barrier inside the nanopore, so as to prevent movement of additional charged molecules through the nanopore.
US08546075B2 Method of detecting hepatitis C virus
A method of treating samples containing hepatitis C virus (HCV) which method comprises treating HCV-containing samples with a treating agent containing (1) an acidifying agent, and (2) a protein-denaturing agent, or an amphoteric surfactant or a cationic surfactant having both a straight chain alkyl group of 10 or more carbon atoms and a tertiary amine or a quaternary ammonium salt in the same molecule, to effect the release of the HCV antigen and the inactivation of antibodies that bind to the HCV antigen, and the like.
US08546074B2 Sir2 activity
Methods for screening a compound, by providing a test mixture comprising a transcription factor, Sir2, and a Sir2 cofactor with the compound, and evaluating an activity of a component of the test mixture in the presence of the compound are described.
US08546072B2 Substrate for assaying β-glucan and/or endotoxin and assay method
An object of the present invention is to provide a peptide derivative for determining β-glucan or endotoxin which allows high sensitivity measurement, and a method for determining β-glucan and/or endotoxin using the same. The present invention relates to (1) a peptide derivative represented by the following general formula [1]: X-A1-Gly-Arg-A2-E-D  [1], (2) a reagent for determining β-glucan and/or endotoxin comprising the above-described peptide derivative, (3) a method for determining β-glucan and/or endotoxin, characterized in that a sample containing β-glucan and/or endotoxin, an amebocyte lysate of a horseshoe crab and the above-described peptide derivative are reacted each other, then the resulting released compound represented by the following general formula [2]: H-A2-E-D  [2] is separated from unreacted substance and quantified, and the determination is made based on this value, and (4) a reagent kit for determining β-glucan and/or endotoxin, comprising an amebocyte lysate of a horseshoe crab and the above-described peptide derivative as constituents thereof.
US08546062B2 Self-forming top anti-reflective coating compositions and, photoresist mixtures and method of imaging using same
A composition of matter. The composition of matter includes a polymer having an ethylenic backbone and comprising a first monomer having an aromatic moiety, a second monomer having a base soluble moiety or an acid labile protected base soluble moiety, and a third monomer having a fluoroalkyl moiety. Also a photoresist formulation including the composition of matter and a method of imaging using the photoresist formulation including the composition of matter.
US08546061B2 Photo-curing polysiloxane composition and protective film formed from the same
A photo-curing polysiloxane composition includes a polysiloxane, an o-naphthoquinonediazidesulfonate compound, and a solvent. The polysiloxane contains 25 wt % to 60 wt % of a polysiloxane fraction having a molecular weight ranging from 10,000 to 80,000 based on a total weight of the polysiloxane when calculated from an integral molecular weight distribution curve obtained by plotting cumulative weight percentage versus molecular weight falling within a range between 400 and 100,000 measured by gel permeation chromatography. The amount of oligomers in the polysiloxane having a molecular weight less than 800 is from 0 wt % to 10 wt % based on a total weight of the photo-curing polysiloxane composition. A protective film formed from the photo-curing polysiloxane composition and an element containing the protective film are also disclosed.
US08546059B2 Photoresist composition
The present invention provides a photoresist composition comprising a resin, an acid generator and a compound represented by the formula (C1): wherein Rc1 represents an aromatic group which can have one or more substituents, Rc2 and Rc3 independently each represent a hydrogen atom, an aliphatic hydrocarbon group which can have one or more substituents or an aromatic group which can have one or more substituents, Rc4 and Rc6 independently each represent a hydrogen atom or an aliphatic hydrocarbon group which can have one or more substituents, or Rc4 and Rc6 are bonded each other to form an alkanediyl group, Rc5 represents an aliphatic hydrocarbon group which can have one or more substituents or an amino group which can have one or two substituents, Rc7 represents a hydrogen atom or an aliphatic hydrocarbon group which can have one or more substituents, or Rc5 and Rc7 are bonded each other to form an alkanediyl group.
US08546057B2 Carbon based black toners prepared via limited coalescence process
A black toner composition comprising toner particles prepared by a chemical process of manufacture comprising carbon black pigment, a first addition polymer comprising carboxylic acid groups along the polymer backbone, and a thermoplastic second polymer binder distinct from the first polymer, wherein the first polymer has an Acid Value of from 30 to 220 and is present at a weight ratio of greater than 1:2 relative to the amount of carbon, and at a relatively lower weight percent than the second polymer. A process for preparation of such toner particles comprising: preparing a masterbatch comprising a carbon black and a first addition polymer comprising carboxylic acid groups along the polymer backbone and having an Acid Value of from 30 to 220, where the first polymer is present at a weight ratio of greater than 1:2 relative to the amount of carbon; dissolving a thermoplastic second polymer binder in an organic solvent; adding the masterbatch to the solution of second polymer binder to form an organic phase, wherein the first polymer is present at a lower weight percent than the second polymer; dispersing the organic phase in an aqueous phase comprising a particulate stabilizer to form a dispersion; and removing the solvent from the organic phase to form toner particles comprising the first polymer, the second polymer binder and carbon black.
US08546055B2 Toner and developer
A toner containing at least a binder resin, releasing agent, and colorant, wherein the binder resin contains polyester resin (A), polyester resin (B), and polyester resin (C), which is prepared by condensation-polymerizing (i) an alcohol component containing an alkylene oxide adduct of bisphenol compound and (ii) a carboxylic acid component; at least one of the polyester resin (A) and polyester resin (B) is a polyester resin prepared by condensation-polymerizing (i) the alcohol component substantially composed of only aliphatic alcohol and containing 1,2-propanediol in an amount of 65 mole % or more of a divalent alcohol component and (ii) the carboxylic acid component; and a softening point Tm(A) of the polyester resin (A) is 10 C or more higher than Tm(B) of the polyester resin (B), and the absolute difference between Tm(C) of the polyester resin (C) and the Tm(B) is 5° C. or less.
US08546051B2 Developer bearing member and process for producing same, development apparatus and development method
A developer bearing member is provided which can charge a toner stably and uniformly during the period from the initial stage to the terminal stage of extensive operation even in various environments. The developer bearing member includes a substrate and an electrically conductive resin coating layer formed on the surface thereof. The electrically conductive resin coating layer is formed from a resin composition containing a phenolic resin having in its structure at least one of an —NH2 group, an ═NH group and an —NH— linkage, a quaternary phosphonium salt and electrically conductive fine particles and the resin composition contains 1 part by mass or more and 60 parts by mass or less of the quaternary phosphonium salt with respect to 100 parts by mass of the phenolic resin.
US08546044B2 Polymer electrolyte, membrane electrode assembly and fuel cell
The present invention easily provides a polymer electrolyte that exhibits high proton conductivity under low humidity conditions and has a high level of durability and mechanical strength. The polymer electrolyte is produced by mixing proton-conducting sulfonated polyethersulfone C1, sulfonated polyphenylene sulfide C2 or sulfonated poly(4-phenoxybenzoyl-1,4-phenylene) C3 having a sulfonic acid group A as a protic acid group with 1,4-benzenedimethanol B as a crosslinking agent having a methylol group and heat-treating the mixture so that a reaction can be carried out. The polymer electrolyte includes a plurality of proton-conducting sulfonated polyethersulfone moieties C chemically bonded at their aromatic ring moieties other than the sulfonic acid group A to one another through a residue B′ of 1,4-benzenedimethanol.
US08546042B2 Membrane electrode assembly and polymer electrolyte fuel cell
In a membrane electrode assembly of the present invention, at least one of a catalyst layer of an oxygen electrode and a catalyst layer of a fuel electrode includes a supported catalyst supporting a metal catalyst containing a platinum group element, a proton conductive polymer electrolyte, and at least one selected from (a) a complex-forming agent having a ligand that forms coordinate bonds with ions of the platinum group element and forms a complex, the ligand containing oxygen as a coordinating atom, (b) a complex of the platinum group element, a ligand of the complex containing oxygen as a coordinating atom, and (c) carbon that has a BET specific surface area of 100 m2/g or greater, satisfies at least one of (i) an R value of Raman spectrum of 0.5 or less and (ii) a lattice spacing d002 between (002) planes of 0.35 nm or less, and does not support the metal catalyst. With the use of the membrane electrode assembly of the present invention, it is possible to provide a polymer electrolyte fuel cell that has high durability and a long service life.
US08546039B2 Solid polymer fuel cell
A solid polymer fuel cell that utilizes liquid fuel such as methanol should prevent generated water from residing in a ventilation port close to an anode, to thereby suppress degradation of a MEA. The fuel cell includes an anode, an anode-side collecting electrode, a sealing material located along a perimeter of a solid polymer electrolytic membrane and interleaved between the electrolytic membrane and the anode-side collecting electrode, and a discharging device that discharges a product generated through electric reaction on the anode. The sealing material is provided in a frame-shape around the anode. The discharging device is a ventilation port formed on the sealing material, and a water repellent material is provided at least one of inside the ventilation port and between the ventilation port and the anode.
US08546036B2 Fuel cell and fuel cell stack
A fuel cell includes separators sandwiching electrolyte electrode assemblies. Each of the separators includes a fuel gas supply section, four first bridges extending radially outwardly from the fuel gas supply section, sandwiching sections connected to the first bridges, and flow rectifier members provided between adjacent sandwiching sections. A fuel gas supply passage extends through the center of the fuel gas supply section. Each of the sandwiching sections has a fuel gas channel and an oxygen-containing gas channel. The flow rectifier members rectify the flow of the oxygen-containing gas supplied from the oxygen-containing gas supply passage to the electrolyte electrode assemblies.
US08546030B2 Hydrogen generator, fuel cell system comprising hydrogen generator, and operation method of hydrogen generator, and operation method of fuel cell system
A hydrogen generator comprises a reformer configured to generate a hydrogen-containing gas through a reforming reaction in an internal space thereof using a material gas and steam; a material gas supply passage through which the material gas is supplied to the reformer; a material gas supplier which is provided at the material gas supply passage to supply the material gas to the reformer; a first valve configured to open and close the material gas supply passage; an evaporator configured to generate a steam supplied to the reformer; a water supplier configured to supply water to the evaporator; a communicating passage for allowing the reformer to communicate with atmosphere; a second valve configured to open and close the communicating passage; and a controller configured to stop the material gas supplier and the water supplier and close the first valve and the second valve at shutdown of the hydrogen generator; and open the second valve prior to opening the first valve when the material gas supplier resumes supply of the material gas to the reformer after the shutdown.
US08546028B2 Electrochemical cell, and particularly a cell with electrodeposited fuel
The present invention relates to a method for charging the cell by electrodeposition of metal fuel on the anode thereof.
US08546025B2 Lithium ion secondary battery
Disclosed is a lithium ion secondary battery, in which comprises a vinyl alcohol polymer or a derivative thereof in an amount of 0.3 mg or more per 1 mAh of battery capacity in terms of a vinyl alcohol unit moiety content. The lithium ion secondary battery can decrease the battery voltage under high-temperature conditions and cannot be recharged after being exposed to high-temperature conditions.
US08546020B2 Nucleation and growth of tin particles into three dimensional composite active anode for lithium high capacity energy storage device
Embodiments of the present invention generally relate to lithium-ion batteries, and more specifically, to a system and method for fabricating such batteries using thin-film processes that form three-dimensional structures. In one embodiment, an anodic structure used to form an energy storage device is provided. The anodic structure comprises a flexible conductive substrate, a plurality of conductive microstructures formed on the conductive substrate, comprising a plurality of columnar projections and dendritic structures formed over the plurality of columnar projections and a plurality of tin particles formed on the plurality of conductive microstructures. In another embodiment, the anodic structure further comprises a tin nucleation layer comprising tin particles formed on the flexible conductive substrate between the flexible conductive substrate and the plurality of conductive microstructures.
US08546018B2 Li—Ni-based composite oxide particles for non-aqueous electrolyte secondary battery, process for producing the same, and non-aqueous electrolyte secondary battery
The present invention relates to Li—Ni-based composite oxide particles comprising Mn, and Co and/or Al, wherein Co and Al are uniformly dispersed within the particles, and Mn is present with a gradient of its concentration in a radial direction of the respective particles such that a concentration of Mn on a surface of the respective particles is higher than that at a central portion thereof. The Li—Ni-based composite oxide particles can be produced by allowing an oxide and a hydroxide comprising Mn to mechanically adhere to Li—Ni-based oxide comprising Co and/or Al; and then heat-treating the obtained material at a temperature of not lower than 400° C. and not higher than 1,000° C. The Li—Ni-based composite oxide particles of the present invention are improved in thermal stability and alkalinity.
US08546015B2 Battery can and alkaline battery
This invention provides a battery can allowing for a reduced amount of gas forming therein, thus realizing lower production cost. The cathode can 11 of an alkaline battery is cylindrically shaped and closed-bottomed, comprising an opening 15, a body 17 and a bottom 18, with the body 17 being divided into an opening sealing section 31 and an electrode mixture container section 33 which are arranged in order from the opening 15, with the plate thickness t0 set for the electrode mixture container section 33, which is not less than 80% of the plate thickness t1 of the opening sealing section 31, with the plate thickness t3 of the electrode mixture container section 33 gradually reducing in the region starting at the topmost point of the electrode mixture container section 33 and ending at the set plate thickness t0.
US08546012B2 Battery pack with electronic monitoring device integrated in the housing cover
A battery pack for an electric power tool has a housing and a housing cover that closes off the housing. Battery cells are arranged in the housing and electrically conductingly connected to one another. An electronic circuit for monitoring operating parameters of the battery cells is provided wherein the electronic circuit is mounted on a circuit board and is arranged in the housing. The housing cover has an inner side facing the battery cells. The inner side has a receptacle that is delimited by an outer receptacle rim. The circuit board is received in the receptacle and is spaced from a bottom of the receptacle so that a filling space is provided between circuit board, bottom of the receptacle, and the receptacle rim. A cured potting compound fills out the filling space.
US08546010B2 Assembled battery and toroidal cell used in the same
An assembled battery with a high capacity, comprising a plurality of unit cells electrically connected with one another in parallel, the unit cells each having a through-hole and being of toroidal shape, and the plurality of unit cells are arranged in a nested manner such that one unit cell is disposed within another unit cell. The problem that toroidal batteries with high capacity, high power density and small thickness may have a large volume and low energy density is solved by connecting in parallel a plurality of unit cells nested within one another, and heat dissipation of the battery is also further improved. A toroidal cell having heat dissipating fins is also provided.
US08546001B2 Fabricating magnetic recording media on patterned seed layers
Patterned media and associated methods of fabrication are provided in which vertical magnetic grains are grown on a patterned seed layer. The patterned seed layer includes a matrix of islands of a first seed material. Each island of first seed material is separated from other islands by a region of second seed material. The first seed material is selected to initiate growth of magnetic material, and the second seed material is selected to initiate growth of non-magnetic material. Subsequently, magnetic material is grown on the first seed material and non-magnetic material is grown on the second seed material. Deposition may be simultaneously. The magnetic and non-magnetic materials form well-defined vertical columns over the first and second seed materials respectively. Thus, each island behaves as an isolated magnetic unit, which switches independently from its neighbor units, which are magnetically separated by the non-magnetic material.
US08545999B1 Method and system for providing a magnetoresistive structure
A method and system for providing a magnetoresistive structure are described. The magnetoresistive structure includes a first electrode, an insertion layer, a crystalline tunneling barrier layer, and a second electrode. The first electrode includes at least a first magnetic material and boron. The crystalline tunneling barrier layer includes at least one constituent. The insertion layer has a first boron affinity. The at least one constituent of the crystalline tunneling barrier layer has at least a second boron affinity that is less than the first boron affinity. The second electrode includes at least a second magnetic material.
US08545996B2 Ion-pairing soft salts based on organometallic complexes and their applications in organic light emitting diodes
Organometallic soft salt compounds are provided. In particular, the compounds comprise mononuclear Ir-based soft salts. The compounds may be used in organic light emitting diodes (OLED) and light emitting cells (LEC).
US08545993B2 Composite material with a ballistic protective effect
A composite material with a ballistic protective effect having a first, outer layer made of a first steel alloy and at least one second layer which is arranged under the first layer and is made of a second steel alloy. The composite material with a ballistic protective effect allows for a reduction in the weight or the wall thicknesses of the composite material in comparison to conventional composite ballistic materials, by utilizing a first steel alloy of the first layer that has the following alloy constituents in percent by weight (% by weight): 0.06%≦C ≦1.05%, 0.05%≦Si≦1.65%, 0.3%≦Mn≦2.65%, 0.015%≦Al≦1.55%; Cr≦1.2%, Ti≦0.13%, Mo≦0.7%, Nb≦0.1%, B≦0.005%, P≦0.08%, S≦0.01%, Ni≦4.0%, and V≦0.05%, the remainder being Fe and inevitable impurities. The second layer of the composite material having a higher elongation than the first layer.
US08545985B2 Coated article with absorbing layer
A coated article is provided with an absorbing layer(s). The coating is, in certain example embodiments, designed so that significant changes in visible transmission can be made by adjusting thickness of the absorbing layer without significantly affecting certain other characteristics such as certain color values. Such coated articles may be used monolithically or in the context of insulating glass (IG) units in different embodiments of this invention, and may or may not be heat treated.
US08545982B2 Hexagonal type barium titanate powder, producing method thereof, dielectric ceramic composition and electronic component
To provide a hexagonal type barium titanate powder having a fine and uniform particle size and contributing to a thinner dielectric layer. A hexagonal type barium titanate powder according to the present invention has the following characteristics that a maximum particle diameter is 1.0 μm or less, a ratio of 90% accumulated particle diameter and 50% accumulated particle diameter is 3.0 or less, and a hexagonal ratio is 50% or more.
US08545976B2 Fibrous structures
Fibrous structures that exhibit a Geometric Mean Modulus (GM Modulus) of less than 1402.4 g/cm at 15 g/cm as measured according to the Modulus Test Method described herein and a Geometric Mean Elongation (GM Elongation or GM Elong) of less than 10.2% measured according to the Elongation Test Method described herein are provided.
US08545975B2 Articles comprising a polyimide solvent cast film having a low coefficient of thermal expansion and method of manufacture thereof
A solvent cast film comprises a polyimide comprising structural units derived from polymerization of a dianhydride component comprising a dianhydride selected from the group consisting of 3,4′-oxydiphthalic dianhydride, 3,3′-oxydiphthalic dianhydride, 4,4′-oxydiphthalic dianhydride, and combinations thereof, with a diamine component comprising 4,4′-diaminodiphenylsulfone; wherein the polyimide has a glass transition temperature from 190° C. to 400° C.; and wherein the film has a coefficient of thermal expansion of less than 60 ppm/° C., a thickness from 0.1 to 250 micrometers, endless than 5% residual solvent by weight.
US08545970B2 Optical compensation film and retardation film
To provide a retardation film and an optical compensation film which have excellent optical properties and are useful as a compensation film for compensating the contrast and viewing-angle characteristics of liquid-crystal displays and as an antireflection film.
US08545966B2 Vibration dampening material and uses for same
The present invention is directed to a material adapted to reduce vibration and, more specifically, to a material adapted to dissipate and evenly distribute transmitted vibrations. The material is particularly suited for impact and/or heavy load vibration resistance.
US08545964B2 Roll-form shock and drainage pad for outdoor field installations
A unitary roll-form shock and drainage pad for an outdoor field installation is formed by a continuous length of shock-absorbing polymer foam sheet. The sheet has a plurality of grooves in its lower surface, the grooves extending continuously along the length of the foam sheet and being spaced apart across the width of the foam sheet, each groove having a crest defining a maximum penetration of the groove through the thickness of the foam sheet. The foam sheet further defines a plurality of rows of vertically extending holes extending from the upper surface of the sheet toward the lower surface, the holes in each row being spaced apart along the length of the foam sheet and being aligned with a respective one of the grooves such that the holes extend into the crest of the groove. A plurality of elongate through-going slots radiate out from each of at least some of the holes.
US08545963B2 Flame-resistant composite materials and articles containing carbon nanotube-infused fiber materials
Flame-resistant composite materials containing carbon nanotubes are described herein. The flame-resistant composite materials contain an outer layer and at least one inner layer, containing a first polymer matrix and a second polymer matrix, respectively. The outer layer has an exterior surface and a first carbon nanotube-infused fiber material that contains a first fiber material and a first plurality of carbon nanotubes greater than about 50 μm in length. In some embodiments, the at least one inner layer also contains a second fiber material and/or a second carbon nanotube-infused fiber material containing a second fiber material and a second plurality of carbon nanotubes. When present, the second plurality of carbon nanotubes are generally shorter in length than the first plurality of carbon nanotubes. Alignment of the carbon nanotubes in the outer layer can transfer heat away from the composite material's inner layer(s). Flame-resistant articles containing carbon nanotube-infused fiber materials are also described.
US08545961B2 Ballistic resistant articles comprising elongate bodies
A ballistic-resistant molded article comprising a compressed stack of sheets comprising reinforcing elongate bodies and an organic matrix material, the direction of the elongate bodies within the compressed stack being not unidirectionally, wherein the elongate bodies are tapes with a width of at least 2 mm and a thickness to width ratio of at least 10:1 with the stack comprising 0.2-8 wt. % of an organic matrix material.
US08545959B2 Composite articles comprising protective sheets and related methods
Methods of the invention include those for applying protective sheets to composite articles. According to these methods and resulting composite articles, a protective sheet is applied to at least a portion of an exterior surface formed from a composite material and where protection is desired. At least one exterior surface of the composite article to be protected can be integrally formed in the presence of the protective sheet. Improved bonding of the protective sheet to the composite article and improved processing efficiency are advantageously achieved according to the invention.
US08545951B2 Endotracheal tubes and other polymer substrates including an anti-fouling treatment
Anti-fouling treatments are applied to polymer substrates for preventing bacterial adhesion. The polymer substrate may comprise a medical device, such as a catheter. The treatment generally comprises a polymer layer graft polymerized to the surface of the polymer substrate. An anti-biofilm agent is contained in the polymer layer or applied to the surface. A polymer over-layer is then applied that encapsulates the anti-biofilm agent. The anti-biofilm agent prevents bacterial adhesion through the polymer over-layer.
US08545948B2 Transparent ink-jet recording films, compositions, and methods
Transparent ink-jet recording films, compositions, and methods are disclosed. Such films do not exhibit excessive ink drying times. These films exhibit high maximum optical densities and have low haze values. These films are useful for medical imaging.
US08545947B2 Transparent substrate with optical compensation ability and liquid crystal display using the same
A transparent substrate with optical compensation ability comprises polyimide having the following chemical formula: wherein A and A′ are cyclic aliphatic or aromatic compounds, B and B′ are cyclic aliphatic or aromatic compounds. In particular, the refractive index of the transparent polyimide is nx=ny>nz, that is, it has ability of adjusting the negative type c-plate phase difference, wherein nx represents the lateral refractive index, ny represents the longitudinal refractive index, nz represents the vertical refractive index along the thickness direction, and m and n are between 10 and 10,000.
US08545944B2 Method for producing solar grade films from semiconductor powders
The present invention relates generally to production of photoelectric grade films or cells from semiconductor powders or dust. In one embodiment, the present invention provides a method for producing a photoelectric grade film from a semiconductor powder. The method includes providing a substrate, coating the substrate with a layer of the semiconductor powder and moving the substrate with the layer of the semiconductor powder under an energy source at a predefined rate, wherein the predefined rate is sufficient to melt the semiconductor powder by the energy source and to cool the substrate such that substantially all impurities are moved to an edge of the substrate.
US08545942B2 Method for producing clathrate compounds
The present invention relates a method for producing clathrate compounds, comprising producing a homogeneous melt containing the desired elements in the desired ratio, and subsequently solidifying said melt to obtain the clathrate compound by quickly cooling the melt.
US08545940B2 Atomic layer deposition apparatus
A reactor configured to subject a substrate to alternately repeated surface reactions of vapor-phase reactants is disclosed. The reactor may include a reaction chamber that defines a reaction space and a gas flow control guide structure; and a substrate holder. The gas flow control guide includes one or more channels. Each of the channels widens as the channel extends from the inlet to the reaction space. At least one of the channels is configured to generate a non-uniform laminar flow at a first portion of the periphery of the reaction space such that the laminar flow includes a plurality of flow paths that provide different amounts of a fluid. The reaction chamber may include a reactor base and a reactor cover detachable from each other; and a driver configured to independently adjust at least three portions of the reactor base to provide a substantially perfect seal to the reactor space.
US08545938B2 Method of fabricating a ceramic component
A method of fabricating a ceramic component includes using vapor infiltration to deposit a ceramic coating within pores of a porous structure to form a preform body with residual interconnected porosity. Transfer molding is then used to deposit a heated, liquid glass or glass/ceramic material into the residual interconnected porosity. The liquid ceramic or ceramic/glass material is then solidified to form a ceramic component.
US08545931B2 Thin line conformal coating method
A coating system with an applicator that has an air cylinder with a needle valve. A control has a timer that provides a string of electrical pulses to a solenoid. With each pulse, the solenoid applies pressurized air to a cylinder piston, thereby opening the needle valve and permitting coating material to flow past the needle valve. The needle valve is closed for durations of time between pulses, and the coating material is ejected from a dispensing needle in response to closings of the needle valve.
US08545928B2 Double layer UV variable data text
A method and system for including a double layer security mark in digital document data defining an image of a document to be printed and in the printed document. A fluorescence mark region including a fluorescence mark is defined using first and second metameric colorant mixtures. Variation in colorant spatial coverage between the first and second metameric colorant mixtures results in colorant-free areas that define the fluorescence mark due to substrate fluorescence under UV illumination. The fluorescence mark region is modified to define a double layer fluorescence mark region including the fluorescence mark and also including at least one visible light object defined by a third colorant mixture. The third colorant mixture is added to the fluorescence mark region by masking the colorant-free areas of the fluorescence mark region to prevent writing of the third colorant mixture data to the colorant-free areas to avoid disturbing the colorant-free areas.
US08545920B2 Human milk compositions and methods of making and using same
The disclosure features human milk fortifier compositions, standardized human milk, and methods of making and using same. In one embodiment, a pasteurized human milk composition includes a human protein constituent of about 35-85 mg/mL; a human fat constituent of about 60-110 mg/mL; and a human carbohydrate constituent of about 60-140 mg/mL.
US08545915B2 Method and apparatus for vitamin D enhancement in mushrooms
An apparatus and method for increasing Vitamin D content in mushrooms irradiates the mushroom(s) for a duration of up to six seconds with one or more pulses of light with wavelengths in the range of about 200 to about 1000 nanometers. The light is emitted by an electric glow discharge lamp, such as a xenon lamp, that emits ultra-violet light. The intensity of the light is such that after irradiation the mushrooms have a Vitamin D2 content of at least about 400 IU/84 g of mushrooms, which is 100% Daily Value of recommended Vitamin D for human consumption.
US08545914B1 Food product carrier set
A carrier for food products such as muffins and cupcakes includes a pan and a cover. The pan including multiple pan wells that project from an upper surface thereof. At least some of the pan wells each includes an opening in respective bottom surfaces thereof. The cover includes multiple cover wells or supports projecting from a surface thereof, each corresponding to one of the pan wells. At least some of the cover wells each includes a support extending from a bottom surface thereof. The cover secures to and substantially covers the pan in a first configuration. The pan nests on the cover in a second configuration such that the supports project through a respective one of the openings.
US08545913B2 Process for preparing, prior to filling, a wafer cornet, cornet thus obtained and installation for implementing the process
Process for preparing a cornet consisting of a substantially conical wafer (22) prior to the filling of said cornet with an ice-cream; in order to preserve the crunchy nature of the wafer, the inner wall of the cornet is sprayed with liquid chocolate (23); this chocolate solidifies rapidly in order to form a coating layer for separating the wafer and the ice-cream. The process is characterized in that the inside of the cornet is sprayed with an excess quantity of chocolate to guarantee that no coating-gap zone remains on the inner wall of the wafer, the excess liquid chocolate collecting, under gravity, at the bottom tip of the corner; prior to solidification of said excess, the excess is sucked out of the cornet, subsequent solidification of the coating layer thus making it possible to establish a continuous barrier over the inner wall of the wafer.
US08545911B2 Method for removing phorbol ester in organic substance, method for producing high-protein organic substance, high-protein organic substance, method for producing feed and feed
A phorbol ester is decomposed by mixing an organic substance containing a phorbol ester and Bacillus substilis var. natto and subjecting the resulting mixture to fermentation. At this time, 4 parts by mass of organic substance containing a phorbol ester is mixed with 0.5 to 3 parts by mass of water, and the resulting mixture is subjected to high-temperature and high-pressure sterilization. Then, a solution obtained by dissolving 0.004 to 0.2 part by mass of Bacillus subtilis var. natto in 0.5 to 1 part by mass of water is added, and the resulting mixture is subjected to fermentation at 30 to 50° C. for two to four weeks.
US08545908B2 Method of producing yeast fermented beverages
The present invention relates to a method of producing yeast fermented beverages, which method comprises the following consecutive continuous processing steps: a. introducing wort into a series of one or more propagation vessels in which it is combined with a recirculated stream of yeast-containing residue and in which the yeast is allowed to propagate under aerobic conditions while being kept suspended; b. transferring the yeast-containing wort from the propagation vessel into a series of one or more fermentation vessels in which the yeast is kept suspended under anaerobic conditions and is allowed to metabolize carbohydrates present in the wort; c. transferring at least a part of the fermented wort from the series of one or more fermentation vessels to one or more separators to remove a yeast-containing residue; d. recirculating part of the yeast-containing residue to the series of one or more propagation vessels; and e. feeding the remainder of the fermented wort to subsequent processing steps; wherein the wet yeast content of the wort in the series of one or more fermentation vessels is maintained at more than 100 g/l. The utilization of very high yeast concentrations offers the advantage that fermentation times and/or fermenter volume can be reduced substantially. Furthermore, continuous fermentations conducted at high yeast concentrations are less vulnerable to microbial infections.
US08545904B1 Topical composition containing Carapa (andiroba) oil for psoriasis and other related dermatological disorders
The subject of the invention is the use of a topical composition for the relief of dermatological disorders, with a primary intention or focus of treating symptoms associated with psoriasis and similar dermatological disorders and/or diseases.
US08545903B2 Composition for the prevention and treatment of influenza virus infection and composition for suppressing neuraminidase activity comprising turmeric extract
Disclosed is a composition comprising a turmeric extract for preventing and treating influenza virus infection and for inhibiting neuraminidase activity. A turmeric extract, its fraction, and a curcuminoid-based compound separated therefrom may inhibit neuraminidase activity and have antiviral and cell degeneration inhibitory effects on influenza virus, and may be useful in preventing and treating influenza virus infection.
US08545902B2 Dosage forms of plant-derived cathartics
Compositions for improved delivery of plant-derived cathartics are disclosed. In one aspect, the compositions comprise a plant-derived cathartic and an effervescence coupling system that, when dissolved into an aqueous medium such as water, produce an effervescent liquid cathartic composition. In another aspect, the compositions comprise a solid dosage form that dissolves or disperses in an aqueous medium to produce a liquid composition that is administered to an individual. The liquid compositions are not only more appealing to a consumer, but also improve the amount and bioavailability of active cathartic components. The cathartic composition is administered to an individual alone or in combination with one or more agents that promote additional laxation, digestion or gastrointestinal health, and/or improve the effectiveness of the plant-derived cathartic composition.
US08545896B2 Compositions, kits and methods for nutrition supplementation
The present invention relates to compositions, kits and methods for the administration of various vitamin, mineral and nutrient compositions, and in a specific embodiment, the compositions, kits and methods may utilize or include twelve carbon chain fatty acids and/or twelve carbon chain acylglycerols, vitamin D, iodine, vitamin B1, vitamin B6, vitamin B12, vitamin B2, vitamin B9, vitamin B3, vitamin E, vitamin A, vitamin C, iron, zinc, copper, magnesium, omega 3 fatty acids and one or more pharmaceutically acceptable carriers.
US08545895B2 Silicate-substituted hydroxyapatite
An inorganic silicate-substituted calcium phosphate hydroxyapatite, useful as a biomaterial, has a Ca/P molar ratio in the range 2.05 to 2.55 and a Ca/(P+Si) molar ratio less than 1.66. The hydroxyapatite can be substantially free of carbonate ions. The material has relatively high solubility and is able to release silicon into solution.
US08545894B2 Porous bioceramic composition for bone repair
The present invention relates to a porous bioceramic composition for bone repair and method of fabrication of the same. 3D-scaffolds were fabricated with a novel micro- and macro-architecture. Porous scaffolds based on dextrin, dextran, gelatin and biomineral (CaCO3) powder were fabricated by heating and freeze-drying methods. Fabrication of different compositions of porous scaffolds (20, 30 wt % of gelatin, 20, 40 wt % dextrin, 30, 40, 50, 60 wt % dextran bounder with the constant quantity of CaCO3 50 g). The scaffolds properties were characterized by x-ray diffraction (XRD), differential scanning calorimetry (DSC), scanning electron microscopy (SEM) and compression tests.
US08545889B2 Co-processed carbohydrate system as a quick-dissolve matrix for solid dosage forms
The present invention comprises a co-processed carbohydrate system, and formulations produced therefrom, which formulations are directly compressible into solid dosage forms, some of which rapidly and completely dissolve or disintegrate in the oral cavity within 60 seconds. The invention also comprises the solid dosage forms produced by directly compressing the co-processed carbohydrate system, some of which, when placed in the oral cavity, shall dissolve or disintegrate, preferably within about 60 seconds.
US08545888B2 Tendon stem cells
The invention relates to tendon stem cell useful for treating a variety of diseases and conditions, including tendon repair and attachment of tendon to bone. The invention is also directed to treatment and/or inhibition of bone formation by use of biglycan and/or fibromodulin.
US08545879B2 Fast disintegrating compositions of meloxicam
The invention provides pharmaceutical compositions comprising a therapeutically effective amount of meloxicam, or a pharmaceutically acceptable salt thereof, wherein the pharmaceutical compositions are in the form of a fast disintegrating dosage form suitable for releasing meloxicam rapidly in the oral cavity. Also provided are processes for preparing a pharmaceutical composition of the invention. Further provided are methods of treating arthritis or pain in a subject in need thereof, the method comprising orally administering to the subject a therapeutically effective amount of a pharmaceutical composition according to the invention.
US08545874B2 Method for making nanolipidic particles
Nanolipidic Particles (NLPs) having average mean diameters of 1 nm to 20 nm are made from a precursor solution. NLPs can be loaded with a desired passenger molecule. Assemblies of these particles, called NLP assemblies, result in a vehicle population of a desired size. Single application or multifunction NLP assemblies are made from the loaded NLPs and range in size from about 30 to about 200 nm. A method of using preloaded NLPs to make larger carrier vehicles or a mixed population provides increased encapsulation efficiency. NLPs have application in the cosmetics, pharmaceutical, and food and beverage industries.
US08545873B2 Percutaneous absorption type plaster
A transdermal patch comprising a backing 2 and an adhesive layer 3 laminated on the backing 2, wherein the adhesive layer 3 comprises a rosin-based resin and petroleum resin as a tackifier, the total compounding amount of the rosin-based resin and the petroleum resin is in a range of 15% by mass to 50% by mass, and compounding amount of the petroleum resin is ⅓ times by mass to 4 times by mass as that of the rosin-based resin.
US08545869B2 Controlling resorption of bioresorbable medical implant material through dispersed responsive particles
The resorption of a medical implant can be controlled with the use of particles embedded in a resorbable bulk material forming the implant or portion thereof. The implant can be removed from a body of a mammal by natural biological mechanisms after use. The resorption of the implant can involve swelling and/or hydrolyzing of the particles within the implant upon contact with a body fluid such that porosity and flow of fluid within the bulk material of the implant is increased. Resorption of the implant may also involve the use of particles with magnetic properties embedded within the implant such that an applied magnetic field causes the particles to vibrate within the bulk material thereby increasing the porosity and thus the flow of fluid, hence facilitating resorption of the implant. The resorption rate of the implant can be controlled by modulating swelling, hydrolysis, or movement of the embedded particles.
US08545867B2 Medical devices having improved performance
According to an aspect of the present invention, medical devices are provided that contain at least one polymeric region which contains (a) at least one block copolymer that contains at least three polymer blocks that differ from one another and (b) at least one therapeutic agent.
US08545864B2 Hemostatic bone graft
The present invention provides a hemostatic bone graft product and method. Hemostatic bone grafts may include demineralized bone matrix in combination with additives. In one embodiment, the graft comprises demineralized bone and polyethylene glycol. Methods for producing the hemostatic bone graft may include mixing demineralized bone with additives to facilitate protein precipitation, surface tension reduction in blood, and/or a cytolytic effect on cells at a bleeding site.
US08545858B2 Porous calcium phosphate bone material
Porous calcium phosphate implant compositions that approximate the chemical composition of natural bone mineral are provided. In addition to calcium phosphate, the compositions include an effervescent agent to promote the formation of interconnected pores and a cohesiveness agent to maintain the shape and hardness of the hardened composition. When introduced at an implant site, the calcium phosphate compositions are remodeled into bone. Methods for using the calcium phosphate compositions, e.g., to repair or replace bone, are also provided.
US08545854B2 Tuberculosis vaccine with improved efficacy
The present invention relates to novel recombinant vaccines providing protective immunity against tuberculosis. Further, the present invention refers to novel recombinant nucleic acid molecules, vectors containing said nucleic acid molecules, cells transformed with said nucleic acid molecules and polypeptides encoded by said nucleic acid molecules.
US08545853B2 Recombinant alpha-hemolysin polypeptide of Staphylococcus aureus, having a deletion in the stem domain and heterologous sequences inserted
It refers to a recombinant alpha-hemolysin polypeptide of Staphylococcus aureus, comprising a deletion in the stem domain, wherein at least one heterologous sequence is inserted in a region selected from the group consisting of regions defined by amino acid position of 108 to 151, 1 to 5, 288 to 293, 43 to 48, 235 to 240, 92 to 97, 31 to 36,or 156 to 161 of SEQ ID NO: 1, with the proviso that, if the heterologous sequence contains five or more consecutive histidines the moiety of the heterologous sequence other than the moiety of five or more consecutive histidines has a minimum length of 11 amino acids; or a variant thereof comprising 1-50 amino acids added, substituted or deleted in SEQ ID NO. 1 and the activity to form oligomers and to bind to lipidic bilayers. It also provides a medicament and vaccine comprising said recombinant polypeptide.
US08545850B2 Anti-CD79B antibodies and immunoconjugates and methods of use
The present invention is directed to compositions of matter comprising immunoconjugates comprising an anti-CD79b antibody comprising: (i) an HVR-L1 sequence of KASQSVDYEGDSFLN (SEQ ID NO: 194), (ii) an HVR-L2 sequence of AASNLES (SEQ ID NO: 195), (iii) an HVR-L3 sequence of QQSNEDPLT (SEQ ID NO: 196), (iv) an HVR-H1 sequence of GYTFSSYWIE (SEQ ID NO: 202), (v) an HVR-H2 sequence of GEILPGGGDTNYNEIFKG (SEQ ID NO: 203), and (vi) an HVR-H3 sequence of TRRVPIRLDY (SEQ ID NO: 204) and to methods of using those compositions of matter for the treatment of hematopoietic tumor in mammals.
US08545847B2 Human antibodies to the human glucagon receptor and methods of use thereof
The present invention provides antibodies that bind to the human glucagon receptor, designated GCGR and methods of using same. According to certain embodiments of the invention, the antibodies are fully human antibodies that bind to human GCGR. The antibodies of the invention are useful for lowering blood glucose levels and blood ketone levels and are also useful for the treatment of diseases and disorders associated with one or more GCGR biological activities, including the treatment of diabetes, diabetic ketoacidosis and long-term complications associated with diabetes, or other metabolic disorders characterized in part by elevated blood glucose levels.
US08545845B2 Antibodies against domains of laminin-332
Antibodies against various domains of laminin-332 are discussed herein. The antibodies reduce the adhesion and matrix binding properties of laminin-332, inhibiting tumor growth and metastasis in vivo. Pharmaceutical compositions and methods of using the antibodies for diagnostic, prophylactic, and/or therapeutic purposes are disclosed.
US08545843B2 Treatment of vasculitis
The present invention concerns treatment of autoimmune diseases with antagonists which bind to B cell surface markers, such as CD19 or CD20.
US08545835B2 Human prostate cell lines in cancer treatment
The invention provides methods and compositions for the treatment of primary, metastatic, and residual cancer in mammals, and more particularly, the use of materials such as whole cells and derivatives and portions thereof to stimulate the immune system to attack cancer.
US08545833B2 Treatment of radiation injury using placental stem cells
The present invention provides a method of extracting and recovering embryonic-like stem cells, including, but not limited to pluripotent or multipotent stem cells, from an exsanguinated human placenta. A placenta is treated to remove residual umbilical cord blood by perfusing an exsanguinated placenta, preferably with an anticoagulant solution, to flush out residual cells. The residual cells and perfusion liquid from the exsanguinated placenta are collected, and the embryonic-like stem cells are separated from the residual cells and perfusion liquid. The invention also provides a method of utilizing the isolated and perfused placenta as a bioreactor in which to propagate endogenous cells, including, but not limited to, embryonic-like stem cells. The invention also provides methods for propagation of exogenous cells in a placental bioreactor and collecting the propagated exogenous cells and bioactive molecules therefrom.
US08545832B2 Lipid depot formulations
The present invention relates to pre-formulations comprising low viscosity, non-liquid crystalline, mixtures of: a) at least one neutral diacyl lipid and/or at least one tocopherol; b) at least one phospholipid; c) at least one biocompatible, oxygen containing, low viscosity organic solvent; wherein at least one bioactive agent is dissolved or dispersed in the low viscosity mixture and wherein the pre-formulation forms, or is capable of forming, at least one liquid crystalline phase structure upon contact with an aqueous fluid. The preformulations are suitable for generating parenteral, non-parenteral and topical depot compositions for sustained release of active agents. The invention additionally relates to a method of delivery of an active agent comprising administration of a preformulation of the invention, a method of treatment comprising administration of a preformulation of the invention and the use of a preformulation of the invention in a method for the manufacture of a medicament.
US08545830B2 Multi-functional polymeric materials and their uses
Multifunctional polymers are disclosed having a smart segment and a biodegradable segment. Advantageously, the biodegradable segment includes a hydrophilic segment and a hydrophobic segment. Embodiments include combining the multifunctional polymeric material with a biologically active substance in an aqueous loading environment and administering the composition as a drug delivery vehicle to a human subject.
US08545828B1 High viscosity heat-treated xanthan gum
The present invention is directed to heat treated xanthan gums, which have improved solution viscosity over other xanthan gums heat-treated under the same processing conditions while maintaining the improved ease of use and the short, non-stringy gel texture of heat treated xanthan gums. Such high solution viscosity xanthan gums are suitable in a variety of applications, including cosmetic and personal care compositions.
US08545826B2 Cosmetic composition
Present invention is on styling composition comprising at least one film forming polymer, at least one polyol at a concentration of 5% by weight or higher and polyacryloldimethyltaurate and/or its salts. The composition of the present invention improves curl retention, curl separation, shine and manageability of hair.
US08545824B2 Glycerol ether mixture, cosmetic composition containing this mixture and process for its production
The invention relates to a glycerol ether mixture which consists essentially of a) at least one C12-22 glycerol monoalkyl ether, b) at least one C12-22 glycerol dialkylether and optionally c) at least one C12-22 glycerol trialkyl ether and/or d) at least one C12-22 fatty alcohol, components a) and b) together making up at least 50% by weight of the glycerol ether mixture and the ratio by weight of component a) to component b) being in the range from 3:1 to 1:2. The invention also relates to a process for producing the glycerol ether mixture and to cosmetic compositions containing the glycerol ether mixture.
US08545822B2 Long wear topical composition
This disclosure relates to a long wear topical composition for keratinous surface. The composition includes at least one coupling agent having at least two reactive functional groups and at least one performance ingredient.
US08545818B2 Hair care compositions and methods of treating hair using same
The present invention provides kits and methods for treating hair on the scalp comprising non-toxic compositions providing beneficial effects on hair without employing high temperatures, free radical initiators or rinsing hair after applying the compositions.
US08545811B2 Solid composition for the oral administration of dyes and diagnostic use thereof
The present application discloses solid compositions for the oral administration of dyes, and diagnostic use thereof. Preferably, such diagnostic use is aimed at the diagnostic evaluation of the gastrointestinal tract.
US08545810B2 Methods and compositions for treatment of ADD/ADHD, depression, memory problems and other conditions
Disclosed herein are compositions and methods for treating a variety of mood and behavioral disorders, including attention deficit hyperactivity disorder (ADHD), anxiety, depression, memory loss, as well as other conditions. Also disclosed herein are methods for diagnosing certain conditions, such as ADHD, using these compositions.
US08545809B2 Methods and compositions for improved 18F labeling of proteins, peptides and other molecules
The present application discloses compositions and methods of synthesis and use of 18F or 19F-labeled molecules of use in PET, SPECT and/or MR imaging. Preferably, the 18F or 19F is conjugated to a targeting molecule by formation of a complex with a group IIIA metal and binding of the complex to a bifunctional chelating agent, which may be directly or indirectly attached to the targeting molecule. In other embodiments, the 18F or 19F labeled moiety may comprise a targetable construct used in combination with a bispecific antibody to target a disease-associated antigen. The disclosed methods and compositions allow the simple and reproducible labeling of molecules at very high efficiency and specific activity in 30 minutes or less. In preferred embodiments, the labeled molecule may be used for imaging in a subject without purification after labeling.
US08545804B2 Method for preparing LTA-type zeolites using a novel structure directing agent
This disclosure relates to LTA-type zeolites which are synthesized using tris[2-(isopropylamino)ethyl]amine as a structure directing agent.
US08545803B2 Modified molecular sieve characterized by improved sodium-contamination-resisting activity and preparation method thereof
Modified molecular sieve characterized by improved sodium-resisting contamination activity and preparation method thereof are provided. The method comprises: adding molecular sieve in phosphorus-containing organic solution, and reacting for 10-200 minutes at temperature of 70-200° C. and pressure of 0.2-1.2 MPa, and then filtering, drying and calcining. The said modified molecular sieve contains 90-99 wt. % molecular sieve as dry basis and 1-10 wt. % phosphorus as oxide. The said method can improve the capability of sodium-resisting contamination effectively, and its technology is simple and fits the existing catalyst production apparatus and process. The said modified molecular sieve has high sodium-resisting contamination activity, and the model catalyst by sodium contamination has high activity retention.
US08545802B2 Process for production of DDR-type zeolite
There is provided a process for producing a DDR-type zeolite having: a raw material solution preparation step of preparing a raw material solution containing 1-adamantaneamine hydrochloride, silica (SiO2), and water at a 1-adamantaneamine hydrochloride/SiO2 molar ratio of 0.002 to 0.5 and a water/SiO2 molar ratio of 10 to 500, and a crystal growth step of subjecting the raw material solution and a DDR-type zeolite powder to a heat treatment in a state that both the raw material solution and the DDR-type zeolite powder are brought into contact with each other to grow crystals of the DDR-type zeolite by the use of the DDR-type zeolite powder as seed crystals.
US08545799B2 EMM-11, a synthetic crystalline microporous material, its preparation and use
EMM-11 is a novel synthetic crystalline microporous material having a single crystalline phase with a unique 3-dimensional channel system comprising three sets of channels, namely a first set comprising 10-ring channels, and a second set and third set comprising 8-ring channels, having a unique T-atom connectivity and X-ray diffraction pattern which identify it as a novel material, and may be prepared with an organic structure directing agent, preferably, 3-isopropyl-1-methyl-1H-imidazol-3-ium. EMM-11 may be used in organic compounds conversion and absorptive processes.
US08545795B2 Continuous process for the preparation of sodium titanate nanotubes
The invention relates to a process carried out continuously in one or more reactors connected in series for the preparation of sodium titanate nanotubes and their derivatives obtained by ion exchange and/or thermal treatment, by reacting titanium oxides with sodium hydroxide under suitable hydrothermal conditions to obtain or control the morphology of nanostructural titanates. The reaction mixture is introduced continuously into the reactor at a feed rate that is the same as the rate of discharge of the product. When more than one reactor is used, the material leaving the first reactor is used to feed the next reactor, and a differential of temperature is applied between the reactors in such a way as to obtain in the average, a temperature of between 60° C. and 180° C.
US08545794B2 Powder NiaMbOx(OH)γcompounds, processes for making the same, and uses thereof in batteries
The invention relates to a powder compound of the formula NiaMbOx(OH)y, wherein M represents Co and at least one element selected from the group consisting of Fe, Zn, Al, Sr, Mg, or Ca and mixtures thereof, or M represents Co Mn and Fe, wherein 0.6≦a<1.0, 0
US08545792B2 Method for making carbon nanotube structure
A method for making a carbon nanotube structure is introduced. The method includes the following steps. A carbon nanotube precursor including a number of carbon nanotubes is provided. The carbon nanotube precursor is placed in a chamber with low oxygen environment. The carbon nanotube precursor is heated in the chamber.
US08545789B2 Method for manufacturing hydroxylamine
Provided is a method for manufacturing hydroxylamine. In this method, an aqueous reaction medium containing acidic buffer agent and nitrate ions in the presence of a limited amount of metal impurities such as Fe or Cu is introduced into a hydroxylamine synthesis reactor in the presence of catalyst to proceed hydroxylamine synthesis by reduction of nitrate ions with hydrogen gas as reducing agent in the aqueous reaction medium to produce hydroxylamine. The reaction is processed in the aqueous reaction medium with a limited amount of metal impurities or even without metal impurities, such that the selection rate of the hydroxylamine product is increased.
US08545787B2 Method of treating an aqueous suspension of kaolin
A method of treating a kaolin particulate material to improve one or more of its properties by removal of impurity particles therein which includes: producing a dispersed aqueous suspension of a kaolin particulate material containing at least 0.1% by weight, based on the dry weight of the kaolin particulate material of separable particulate impurity; diluting said dispersed aqueous suspension by adding a diluent thereto; adding a selective flocculation polymer to the diluted suspension; allowing the suspension containing the polymer to separate in a selective flocculation separator into layers comprising a flocculated product layer and a deflocculated impurity layer containing the separable impurity; and extracting the separated layers from the separator, wherein at least a portion of said deflocculated impurity layer is recirculated for use as at least a portion of the aforementioned diluent.
US08545784B2 Method for the production of rare earth containing phosphates
A method for the synthesis of rare earth containing phosphates of the LaPO4:Ce,Tb type comprising providing an initial charge of phosphate having a pH above 2 to a reactor; subsequently commencing introduction of a rare earth solution to the reactor, and subsequently, continuing to introduce both the phosphate and the rare earth solution to the reactor to form a mixture; whereby a rare earth phosphate precipitate is produced, at least a portion of which is precipitated while the pH of the mixture is less than 2.
US08545781B1 Carbon dioxide adsorbent composition
The carbon dioxide adsorbent composition relates to a material that will adsorb carbon dioxide gas from the atmosphere and that is made by the treatment of oil fly ash with ammonium hydroxide. In order to make the carbon dioxide adsorbent, oil fly ash is first mixed with ammonium hydroxide. This mixture is then refluxed and cooled. Additional ammonium hydroxide is added to the cooled mixture of oil fly ash and ammonium hydroxide to form a secondary mixture. This forms an amine-functionalized fly ash composition, which is then filtered from the secondary mixture to be used as a carbon dioxide adsorbent composition. The carbon dioxide adsorbent composition is then dried and may be used as a carbon dioxide adsorbent for gas streams, such as flues and exhaust systems, containing carbon dioxide.
US08545779B2 Sulfur-tolerant perovskite NOx oxidation catalysts
A method for catalytic oxidation of NO to NO2 in the sulfur-containing exhaust gases of lean-burn engines, such as diesel engines is disclosed. The catalysts are oxide perovskites with a credible likelihood of being sulfur-tolerant.
US08545777B2 Method of making an acid-absorbing biosolid composition
The method of making an acid-absorbing biosolid composition provides a method for the use of recycled materials to produce an acid-absorbing composition that may then be recycled as a fertilizer after absorbing the acid. The method includes the steps of: collecting sewage sludge; drying the sewage sludge to remove water therefrom to form dried sludge; adding hydrochloric acid to the dried sludge to form a liquid intermediary product; heating the liquid intermediary product to produce a dried porous biomass; and mixing inorganic waste material with the dried porous biomass to produce the acid-absorbing biosolid composition. Thereafter, the acid-absorbing biosolid composition may be placed in a gas flow to absorb an acidic component therefrom; and then recycled for use as fertilizer following absorption of the acidic component from the gas flow.
US08545774B2 Electrical connection system for an electrochemical analysis system
An electrical connection system for an analysis system and a method for analysis of a liquid sample on an analytical test element using the described analysis system are disclosed. The analysis system provides an evaluation appliance for evaluation of electrical signals, a test element holder for holding and positioning of an analytical test element in a measurement position, and an electrical contact element which makes electrical contact with an electrical contact surface of an analytical test element to produce an electrical connection between the contact surface and the evaluation appliance. The contact element is moved by means such that contact with the electrical contact surface of the test element is made when the test element holder is in the measurement position.
US08545773B2 Versatile multichannel capillary biosensor system
The multichannel capillary biosensor system includes a selecting valve system for selection of the sample or a reagent. The selecting valve system is connected to a second valve system accommodating a sensing channel and a first bypass channel. The second valve system is connected to a directing valve system having at least two positions, with a first position being connected to a second bypass channel and a second position being connected to a detector for detecting the analyte. The device has a pump connected at one end to the second bypass channel and the detector and at a second end to a waste vessel. The device also has a control system for controlling the device. The analyte can be selected from the group of microorganisms, macromolecules, and small molecules.
US08545771B2 Fluidic devices having incorporated electrodes
The invention provides fluidic devices having incorporated electrodes. One device comprises a card and first and second caddy segments. The first caddy segment comprises first and second electrodes. The second caddy segment comprises first and second reservoirs disposed on a first surface of the second segment, a channel disposed on a second surface of the second segment, and first and second vias extending between the first and second surfaces. The first caddy segment is attached to the first surface of the second caddy segment. The card is attached to the second surface of the second caddy segment such that the card provides a closed surface for the device.
US08545770B2 Method for improving the bonding properties of microstructured substrates, and devices prepared with this method
A method for treating the surface of a polymerio substrate, including the following steps: providing a first polymeric substrate; contracting at least one part of one face of the first substrate with some liquid solvent system, the liquid solvent system containing at least a first volatile compound and at least a second compound having a low molecular weight and able to swell and/or soften the polymeric material forming the face; letting at least the volatile compound to evaporate from the face of the first substrate and; contracting the so-treated face of first substrate with a third material.
US08545765B2 Plasma treating apparatus
A first electrode, a second electrode and a third electrode are provided in a middle of a passage. The second electrode is provided on an upstream side of the first electrode, and the third electrode is provided on a downstream side of the first electrode. A connecting line connects the first electrode to a first pole of a pulsed power supply, and connects the second electrode and the third electrode to a second pole of the pulsed power supply. The first electrode crosses a first gas passing surface and occupies a part of the first gas passing surface. The second electrode and the third electrode cross a second gas passing surface and a third gas passing surface and occupy a part of the second gas passing surface and the third gas passing surface respectively.
US08545764B2 Microplasma array
A microplasma array for the production of low-temperature plasmas at or near atmospheric pressures is described. The walls of holes made in a substrate at regular intervals with respect to one another form hollow electrodes and are coated with metal. The hollow electrodes are supplied individually or as a group from one side of the substrate with an electrical excitation in the GHz-region.
US08545759B2 Noninvasive bioreactor monitoring
A pair or receptacles capable of housing an emitter probe and a detector probe are installed inside a bioreactor to monitor the properties of the nutrient media without contacting the nutrient media.
US08545758B2 Microparticle sorting apparatus, flow cytometer using the same and microparticle sorting method
Disclosed herein is a microparticle sorting apparatus, including: a discharge direction confirming section configured to confirm a discharge direction of a discharged liquid discharged from a discharge outlet of a flow path; opposite electrodes disposed downstream with respect to the discharge outlet; an opposite electrode position controlling section configured to control positions of the opposite electrodes in accordance with the discharge direction confirmed by the discharge direction confirming section; a droplet generating section configured to generate a droplet from the discharge outlet; and a charging section configured to electrically charge the droplet with electric charges.
US08545752B2 Cooling plate for a metallurgical furnace
A cooling plate (10) for a metallurgical furnace in accordance with the present invention has a panel-like body (12) with a front face (14) and an opposite rear face (16), an upper edge (22) and an opposite lower edge (24), and a first side edge (18) and an opposite second side edge (20). The front face (14) is provided with grooves (32) extending between the first and second edges (18, 20), the grooves (32) forming lamellar ribs (34) on the front face (14), each rib (34) having a crest (37) and adjoining sidewalls (39, 39′), a base (38) being arranged in the groove (32) between two neighboring ribs (34). In accordance with an important aspect of the present invention, at least one of the grooves (32) is provided with a metal insert (40) arranged against at least one of the sidewalls (39, 39′).
US08545751B2 Refractory nozzle
A refractory nozzle assembly comprising a vessel operable to contain a molten metal and having at least one outlet. The assembly includes an inner assembly having an aperture extending therethrough and an outer assembly having an aperture extending therethrough. The inner and outer assemblies are arranged in the outlet of the vessel and are arranged for relative lateral movement such that inner and outer assemblies are operable to move between an open configuration, where the apertures therethrough are generally overlapping, and a closed configuration, where the apertures are not overlapping. The junction between the inner and outer assemblies is located within a periphery of the vessel.
US08545746B2 Method of making a substrate having multi-layered structures
A method of making a substrate having multi-layered structures thereon, the method comprising the steps of (a) applying a mold having an imprint forming surface to the substrate to form an array of imprint structures that projects from the substrate; and (b) applying a lateral force that is substantially normal to said projecting imprint structures to cause said imprint structures to move angularly towards said substrate and thereby form a pattern of multi-layered structures thereon.
US08545743B2 Method of manufacturing an article of footwear with multiple hardnesses
A method of forming an article of footwear includes injecting a first material into a first cavity of a mold assembly to form a sole assembly, injecting a second material into a second cavity of the mold assembly, a first last being suspended within the second cavity, to form an upper of the article of footwear about the first last. The upper and the sole assembly are positioned in contact with one another. The upper and the sole assembly are cured and bonded together to form an article of footwear. The article of footwear is removed from the mold assembly and from the first last and allowed to expand to a first size. The article of footwear is placed on a second last having a second size that is smaller than the first size, and heated and cooled until it shrinks to the second size.
US08545742B2 Method of fabricating a low crystallinity poly(L-lactide) tube
Methods of fabricating a low crystallinity polymer tube for polymers subject to strain-induced crystallization. The low crystallinity tube may be further processed to make an implantable medical device.
US08545740B2 Releasable fastening arrangement
The present disclosure provides embodiments of a releasable fastening arrangement that can include a first fastening strip secured to and extending over a substrate surface and having a first surface carrying first fastening elements extending from the surface. The releasable fastening arrangement can also include a second fastening strip having a second surface carrying second fastening elements that are engageable by the first fastening elements to form a releasable fastening. The first surface can include a flexible flap that is formed therein, and that is surrounded by other portions of the first surface. The flap can carry at least one of the first fastening elements, and can flap have a distal edge that is displaceable from the substrate surface under peel loads applied to the at least one first fastening element carried by the flap.
US08545735B2 Material of phosphorus-doped lithium titanium oxide with spinel structure and method of manufacturing the same
A material of phosphorus-doped lithium titanium oxide with spinel structure includes a plurality of lithium titanium oxide particles, wherein a portion or the entirety of the surface layer of the lithium titanium oxide particle is doped with phosphorus. The surface layer is from 1 to 10 nanometers in thickness. Alternatively, the entire lithium titanium oxide particle can be doped with phosphorus. The material can be in powdered form, including a plurality of micro-scale particles each constituted by a plurality of the lithium titanium oxide particles.
US08545732B2 Electrode film for polymer actuator element, and polymer actuator element comprising the same
An electrode film for a polymer actuator element contains a fluororesin, a fluorine rubber, an ionic liquid, and a conductive filler.
US08545730B2 Electroconductive carbon fibril-based inks and coatings
Provided are inks and coatings including carbon nanotubes.
US08545727B2 Process for producing ammonia synthesis gas
A process for producing ammonia synthesis gas, where a natural gas feedstock (10) is reformed in a primary steam reformer (12) and in a secondary reformer (14) at a pressure of at least 35 bar; the product syngas (16) at the output of the secondary reformer is cooled and subject to catalytic medium-temperature shift, converting the CO into CO2 and H2; downstream said medium-temperature shift, the carbon dioxide is removed from the syngas by physical absorption.
US08545725B2 Method and facility for converting carbon monoxide and water into carbon dioxide and hydrogen, with the removal of at least one product gas
A process for carrying out a carbon monoxide shift reaction is provided. In the implementation of the carbon monoxide shift reaction, including the conversion of carbon monoxide and water into carbon dioxide and hydrogen, this conversion takes place in the liquid phase and involves separation of the product gases carbon dioxide and/or hydrogen, where as a first solvent dry methanol is used, for the absorption of carbon monoxide with simultaneous formation of a methyl formate, as a second solvent, in the area of release of the product gases, water is used, for avoiding hydrogen losses in a carbon dioxide area.
US08545722B2 Illumination system comprising a radiation source and a luminescent material
An illumination system, comprising a radiation source and a luminescent material comprising at least one phosphor capable of absorbing a part of light emitted by the radiation source and emitting light of wavelength different from that of the absorbed light; wherein said at least one phosphor is a yellow red-emitting cerium(III)-activated alkaline earth oxonitridoaluminosilicate of general formula Ca1−x−yAxAl1+a−bBbSi1−aN3−aOa:Cey, wherein A selected from the group comprising beryllium, magnesium, strontium, barium, zinc, manganese, lithium, sodium, potassium, rubidium, praseodymium, samarium, europium, and B selected from the group comprising boron, gallium, scandium and wherein 0
US08545719B2 Liquid crystal polyester composition and process for producing the same
The present invention provides a liquid crystal polyester composition, comprising (i) 100 parts by weight of a liquid crystal polyester, and (ii) 65 to 100 parts by weight of a combination of a fibrous filler with a plate-like filler, wherein the fibrous filler has a number-average fiber diameter of 5 to 15 μm, and a number-average aspect ratio of 20 to 40, and a content ratio by weight of the fibrous filler to the plate-like filler is more than 1.0 and 1.6 or less; and a process for producing the liquid crystal polyester composition comprising a step of melt-kneading the above respective components with one another.
US08545712B2 Semiconductor wafer manufacturing method
In a method of manufacturing semiconductor wafers, front and back surfaces of the semiconductor wafers are simultaneously polished with a double-side polishing machine that includes: a carrier for accommodating the semiconductor wafer; and an upper press platen and a lower press platen for sandwiching the carrier. The method includes: accommodating the semiconductor wafer in the carrier while a thickness of the semiconductor wafer is set to be larger than a thickness of the carrier by 0 μm to 5 μm; and polishing the semiconductor wafer while feeding a polishing slurry to between the surfaces of the semiconductor wafer and surfaces of the press platens. In the polishing, an allowance of both surfaces of the semiconductor wafer is set at 5 μm or less in total.
US08545710B2 Ion radiation damage prediction method, ion radiation damage simulator, ion radiation apparatus and ion radiation method
An ion radiation damage prediction method includes a parameter computation step of computing the collision position and the incidence angle of an incident ion hitting a fabricated object by considering a transport path of the ion and by adopting the Monte Carlo method which takes distributions of flux quantities, incidence energies and angles of incident ions as input parameters; and a defect-distribution computation step of searching for data by referring to information found at the parameter computation step and databases created in advance, the databases storing distributions of quantities of crystalline defects having an effect on the fabricated object, ion reflection probabilities and ion penetration depths, finding the penetration depth and location of the incident ion based on the data found in the search operation, and the incidence energy and angle of the incident ion, and computing a distribution of defects in the fabricated object from the penetration depth and location.
US08545709B2 Critical dimension control during template formation
Thickness of a residual layer may be altered to control critical dimension of features in a patterned layer provided by an imprint lithography process. The thickness of the residual layer may be directly proportional or inversely proportional to the critical dimension of features. Dispensing techniques and material selection may also provide control of the critical dimension of features in the patterned layer.
US08545708B2 Mold and manufacturing method therefor
A mold of the present invention includes: a flexible polymer film; a curable resin layer provided on a surface of the polymer film; and a porous alumina layer provided on the curable resin layer, the porous alumina layer having an inverted moth-eye structure in its surface, the inverted moth-eye structure having a plurality of recessed portions whose two-dimensional size viewed in a direction normal to the surface is not less than 10 nm and less than 500 nm. According to the present invention, a method for easily forming a flexible moth-eye mold which can be deformed into the form of a roll is provided.
US08545706B2 Apparatus and process for isomerizing a hydrocarbon stream
One exemplary embodiment can be an apparatus for isomerizing a hydrocarbon stream rich in a C4 hydrocarbon and/or at least one of a C5 and C6 hydrocarbon. The apparatus can include: a first drier and a second drier adapted to receive a fluid including at least one reactant; and a reaction zone communicating with the first drier to receive the fluid including at least one reactant and with the second drier to receive the regenerant. Generally, the first drier operates at a first condition to dry the fluid including at least one reactant and the second drier operates at a second condition during regeneration with a regenerant. The regenerant can pass through a fluid tapering device for regulating the flow of the regenerant to the reaction zone.
US08545702B1 Production of biodiesel from feedstock
Process and steps for the production of biodiesel and/or glycerin from feedstock are provided.
US08545701B2 Induced symbiotic osmosis [ISO] for salinity power generation
A method comprising providing a power train comprising a plurality of cells, each cell forming a hydraulic loop; producing a power train cycle comprising a controlled concentration-pressure loop wherein the concentration field: (a) osmotically induces a continuous and constant flow rate of substantially salt-free permeate flux throughout the power train; (b) maintains a salt concentration difference across the semipermeable membrane shared by the adjacent cells in the plurality of cells; (c) defines a salt concentration ratio within each cell that ensures a net positive power generation; and, (d) discharges the concentrated brine at the opposing end cell; and operating the power train under conditions effective to generate net positive power at an efficiency of 35% or more.
US08545700B1 Reduction and control of pH and soluble CO2 for optimal nitrification of wastewater
The invention includes a method for the optimization of the soluble CO2 concentration in the aeration basin of an activated sludge system, which significantly improves the specific growth rate of the nitrifying bacteria. The result is a reduction in capital and energy costs for municipalities. The rate of nitrification is a product of the nitrifying bacteria biomass concentration and the specific growth rate of the bacteria. In the activated sludge system, the biomass concentration is maintained at high concentrations by reducing the wasting rate. The specific growth rate is a function of the ammonium concentration and the environmental conditions. Here, the inventors show that growth of nitrifying bacteria is inhibited when the soluble CO2 concentration is elevated beyond certain parameters. Elevated soluble CO2 concentration also reduces the pH, which also impacts the rate of growth of nitrifying bacteria.
US08545699B2 Filter assembly for frying oil or other liquids and an associated valve assembly
A filter assembly is provided. Embodiments of the filter assembly allow for the continuous filtering of the frying oil, while the fryer is on-line. The filter assembly may include a dirty chamber, a clean chamber, a pump configured to suck the frying oil through the chambers, and a toggle clamp configured to move the filter assembly between a closed configuration and an opened configuration. In the closed configuration, the filter assembly is configured to seal a filter media portion between the two chambers. The pump is configured to suck oil into the dirty chamber and through the filter media and into the clean chamber in order to filter dirt from the oil. In the opened configuration, the filter assembly is configured to allow the removal of now dirty filter media portion from between the chambers and the insertion of a new clean filter media portion.
US08545697B2 Water-dissolvable device for treatment of waste material
A device for the treatment of waste material in a waste water collection system includes an inner core and an outer portion partially surrounding the inner core such that at least one surface of the inner core is exposed. The inner core has a greater water solubility than the outer portion.
US08545696B2 Sediment and detention basin drainage system and method
A fluid drainage system configured for draining a basin impounding fluid and sediment, solids or the like of varying density and turbidity. The system includes a first conduit and a second conduit within or adjacent to the first conduit to form a fluid receiving chamber between the first and second conduits, each conduit having apertures therethrough, with the apertures of the first and second conduits being sized and arranged relative to one another and so configured as to preferentially discharge fluid from the top of a basin, thus providing flow conditions which inhibit the entry of sediment into the system so as to maximize the retention of sediment within the basin and reduce turbidity and Total Suspended Sediment in the discharged fluid.
US08545694B2 Aromatics saturation process for lube oil boiling range feedstreams
An improved aromatics saturation process for use with lube oil boiling range feedstreams utilizing a catalyst comprising a hydrogenation-dehydrogenation component selected from the Group VIII noble metals and mixtures thereof on a mesoporous support having aluminum incorporated into its framework and an average pore diameter of about 15 to less than about 40 Å.
US08545691B2 Aqueous medium management via super absorbent materials
A super absorbent polymer material is contacted with an aqueous medium to absorb at least a portion of the aqueous medium. At least portion of the aqueous medium absorbed super absorbent material is subsequently regenerated to release water therefrom and to form a regenerated super absorbent material suitable for the contacting with a second quantity of an aqueous medium. Also disclosed are layered composites including an electrically conductive metal support layer, a layer of super absorbent material disposed thereon, and a layer of a selective semi-permeable material disposed adjacent the layer of the super absorbent material and spaced apart from the electrically conductive metal support layer.
US08545690B1 Purification method of zinc sulfate leachate
A purification method of zinc sulfate leachate is provided. The purification method of zinc sulfate leachate comprises contacting the zinc sulfate leachate with a zinc powder under a non-oxidizing atmosphere to form solution containing a precipitate of impurity metal; and removing the precipitate of impurity metal from the solution and getting a purified zinc sulfate leachate. A purified zinc sulfate leachate may be prepared with a higher purification efficiency and a lower energy consumption than prior art.
US08545688B2 Method for electrochemically depositing carbon nitride films on a substrate
Dense carbon nitride films are electrochemically formed on a conductive substrate by placing the substrate acting as cathode in a molten salt electrolyte bath and applying DC current across the substrate and a counter electrode acting as anode also placed in the molten salt electrolyte bath. Carbonate ion and nitrate ion are concurrently reduced to deposit carbon nitride films on the substrate.
US08545684B2 Sensing element and method of making the same
Disclosed herein is a method of making a sensing element comprising forming an electrically conductive element, wherein the sensing element comprises a metal selected from the group consisting of Pd and alloys and combinations comprising Pd; and wherein the electrically conductive element is thermally stable at temperatures as high as 1,200° C.
US08545680B2 Center feed system
A center feed system for use within a delayed coking system, or any other similar system is described. The center feed system features an inlet sleeve which slidably engages a retractable nozzle, with inlet and outlet, in fluid connection with a feed source of residual byproduct, allowing residual byproduct to flow from the feed source into the interior of a vessel, thus effectuating or inducing even thermal distribution throughout the vessel.
US08545677B2 Calender for treating a product web
Calender (1) for calendering a paper or board web (2), having at least one nip (3), which is formed between a heatable roll (4) and a mating element (5), a device (6) for producing a predetermined pressure in the nip (3), and a web treatment device (7) arranged upstream of the nip (3) and having two contact surfaces (9, 10) forming a treatment nip (8), one of which is a circulating contact surface (9) which is formed by a belt (14) circulating on guide rolls (11, 12, 13), the other contact surface (10) is formed by the circulating surface of the heatable roll (4), and the treatment nip (8) extends along an angle (15) of the wrap of the heatable roll (4), wherein, in order to increase the thermal efficiency of the transfer of heat, the circulating belt (14) uses a resilient surface to press the paper or board web (2) onto the heatable roll (4), and the guide rolls (11, 12, 13) control sectional forces of the circulating belt (14) in the treatment nip (8).
US08545674B2 Method to use heat energy from black liquor
The method is for retrieving heat from black liquor wherein the black liquor is withdrawn from a digester in association with the production of cellulose pulp. The black liquor at the withdrawal stage maintains a first withdrawal temperature. At least a part of the black liquor is led to a heat exchanger. An exchange of heat takes place in the heat exchanger between the black liquor and a bleaching filtrate that has been obtained from the bleaching plant. The exchange of heat results in the bleaching filtrate experiencing a raise in temperature of at least 5° C., after which the heated bleaching filtrate is used in the bleaching plant.
US08545673B2 Process for recovering molybdate or tungstate from aqueous solutions
Process for recovering molybdate or tungstate from an aqueous solution, in which molybdate or tungstate is bound to a water-insoluble, cationized inorganic carrier material from the aqueous solution at a pH in the range from 2 to 6, the laden carrier material is separated off and the bound molybdate or tungstate is liberated once again into aqueous solution at a pH in the range from 6 to 14. The process is suitable for recovering molybdate or tungstate in the delignification of pulp with hydrogen peroxide in the presence of molybdate or tungstate as catalyst. The recovered molybdate or tungstate can be recycled to the delignification.
US08545670B2 Plasma processing apparatus and plasma processing method
A plasma processing apparatus for processing a substrate using plasma includes a first electrode configured to mount the substrate, a second electrode disposed to face the first electrode with a predetermined space, a chamber containing the first electrode and the second electrode, the chamber being capable of adjusting an inside atmosphere, a first electric power source device configured to apply a first RF voltage for controlling a self-bias voltage generated on the substrate to the first electrode, the first electric power source device applying a substantially constant width and a substantially constant value in a peak-to-peak voltage of an RF voltage of a first frequency at intervals, and a second electric power source device configured to apply a second RF voltage of a second frequency for generating plasma between the first and second electrodes to one of the first electrode and the second electrode.
US08545668B2 Substrate processing apparatus and substrate processing method
A substrate processing apparatus comprises a substrate holding mechanism, a process liquid supplying mechanism supplying a process liquid, a first guide portion around the substrate holding mechanism having an upper edge portion extending toward the rotation axis for guiding scattered process to flow down, a second guide portion provided around the substrate holding mechanism outside the first guide portion and having an upper edge portion extending toward the rotation axis as vertically overlapping with the upper edge portion of the first guide portion for further guiding the scattered process liquid to flow down, a recovery channel provided outside and integrally with the first guide portion for recovering the process liquid guided by the second guide portion, and a driving mechanism for moving up and down the first guide portion and the second guide portion independently of each other.
US08545667B2 Pumpable epoxy paste adhesives resistant to wash-off
This invention relates to compositions useful as adhesives and more particularly to the preparation of heat-curable epoxy-based adhesive compositions that are capable of being easily pumped under high shear at temperatures around room temperature but are resistant to being washed off substrate surfaces prior to being cured.
US08545663B2 Process for manufacturing semiconductor devices
In a process for manufacturing a semiconductor device comprising heating a wiring board on which a chip and an uncured adhesive layer are laminated for curing the adhesive layer, the improvement includes performing a statically pressurizing step before the adhesive layer is cured, in which step the wiring board on which the chip and the uncured adhesive layer are laminated is subjected to a static pressure greater than atmospheric pressure by not less than 0.05 MPa. According to the process, voids are easily eliminated irrespective of the design of the wiring board, and the adhesive is prevented from curling up on the chip.
US08545662B2 Swing out mold insert device on lay up molds
An apparatus and method in which an insert with an undercut is mechanically coupled to a lay up mold for translated movement between an engaged position for molding with an undercut engaging the material to be molded and a remote position in which a resultant molded product maybe removed and the material may be laid up without interference with the undercut, preferably with the mechanical coupling allowing for hinged movement of the insert relative the lay up mold.
US08545661B2 Manufacture of organically developable, photopolymerizable flexo-graphic elements on flexible metallic supports
A process for the manufacture of organically developable, photopolymerizable flexographic elements on flexible metallic supports by coating a flexible metallic support with a tack-free adhesive coating composition which is insoluble and non-swelling in printing inks and organic developers, attaching an elastomeric, photopolymerizable layer to a protective film, and laminating the photopolymerizable layer to the metallic support coated with said adhesive coating composition. A photopolymerizable flexographic element comprising a photopolymerizable layer which is attached to a metallic support by means of a tack-free adhesive film that is non-swelling and insoluble in printing inks and organic developers.
US08545656B2 Method of manufacturing resin pipe
Disclosed is a method for manufacturing a resin pipe, including: heating a sheet member after winding the sheet member around a bar desired multiple times and holding the sheet member, wherein the sheet member is melted and molded into a resin pipe by the heating, and the bar is removed from the resin pipe after the heating.
US08545654B2 Pant-type absorbent article and a method for producing pant-type absorbent articles
A method for producing pant-type absorbent articles, each article including a chassis structure having at least one elastic panel and an integrated absorbent core component, the method including a continuous pant-forming process including forming the chassis structure and incorporating the absorbent core component into the chassis structure. The at least one elastic panel is formed by a) separately producing a two-layer laminate having a first non-elastic fibrous nonwoven web and an elastic film, b) activating the two-layer laminate by incremental stretching in at least one activation direction to render the two-layer laminate (elastically stretchable, c) stretching the activated two-layer laminate by 35-200% in the activation direction, d) introducing the two-layer laminate in the pant-forming process, and e) laminating the elastic film of the stretched two-layer laminate to an elastic or nonwoven chassis component. An absorbent pant-type article produced in accordance with the method.
US08545644B2 Method for producing a vacuum-insulated double container
The present invention is aimed at providing a method for producing a vacuum-insulated double container that exhibits a remarkable and heretofore unobtainable operating effect. The invention provides a method for producing a vacuum-insulated double container by placing a titanium internal cylinder (2) into a titanium external cylinder (1) via a space section (S), and using the space section (S) between the external cylinder (1) and the internal cylinder (2) as a vacuum-insulating space section, the method comprising the steps of degassing the space section (S) of a workpiece (3) that includes the external cylinder (1) and the internal cylinder (2), and vacuum sealing a degassing hole while the workpiece (3) is heated in a vacuum heating furnace (6); and then providing concavoconvex portions (4, 5) to a surface of the recrystallized external cylinder (1) and the internal cylinder (2) by placing the workpiece (3) in an atmospheric-pressure environment.
US08545643B2 High temperature low thermal expansion Ni-Mo-Cr alloy
An alloy designed for use in gas turbine engines which has high strength and a low coefficient of thermal expansion is disclosed. The alloy may contain in weight percent 7% to 9% chromium, 21% to 24% molybdenum, greater than 5% tungsten, up to 3% iron, with a balance being nickel and impurities. The alloy must further satisfy the following compositional relationship: 31.95
US08545641B2 Method and system for manufacturing sintered rare-earth magnet having magnetic anisotropy
A method for manufacturing a sintered rare-earth magnet having a magnetic anisotropy, in which a very active powder having a small grain size can be safely used in a low-oxidized state. A fine powder as a material of the sintered rare-earth magnet having a magnetic anisotropy is loaded into a mold until its density reaches a predetermined level. Then, in a magnetic orientation section, the fine powder is oriented by a pulsed magnetic field. Subsequently, the fine powder is not compressed but immediately sintered in a sintering furnace. A multi-cavity mold for manufacturing a sintered rare-earth magnet having an industrially important shape, such as a plate magnet or an arched plate magnet, may be used.
US08545640B2 Substrate processing method, storage medium storing computer program for performing substrate processing method, and substrate processing apparatus
In a substrate processing method according to the present invention, a cleaning liquid nozzle supplies a rinsing liquid to a central portion of a substrate and thereafter moves from a position corresponding to the central portion of the substrate to a position corresponding to a peripheral, edge portion thereof while supplying the rinsing liquid before stopping at the position corresponding to the peripheral edge portion. Next, a drying liquid nozzle moves from the position corresponding to the peripheral edge portion to the position corresponding to the central portion while supplying a drying liquid. Then, the drying liquid nozzle is kept stationary at the position corresponding to the central portion for a predetermined period of time while supplying the drying liquid. Thereafter, a gas nozzle moves from the position corresponding to the central portion to the position corresponding to the peripheral edge portion while supplying an inert gas.
US08545639B2 Method of cleaning aluminum plasma chamber parts
A method of cleaning a surface of a component of a plasma chamber, wherein the component has an aluminum or anodized aluminum surface, the method including the steps of: soaking the surface of the component in a diluted sulfuric peroxide (DSP) solution; spray rinsing the surface with water following removal of the surface from the DSP solution; soaking the surface in a dilute nitric acid (HNO3) solution; spray rinsing the surface with water following removal of the surface from the dilute nitric acid solution; and repeating at least twice the steps of soaking the surface in dilute nitric acid followed by spray rinsing the surface.
US08545635B1 Hard floor surface care process
A hard floor surface care process comprising a process of identifying, cleaning, polishing, and protecting manmade and natural stone hard floor surfaces having a single surface or multi-surface quality. The hard floor surface care process comprising an acid reactive or nonreactive hard floor surface identifying process; an emulsifying solution, agitating, and toweling cleaning process; a polishing process utilizing a lubricating solution with a polishing chemistry or pad, and a protecting process utilizing a protecting chemistry selected as a function of the identifying process.
US08545632B2 Coating holder and coating device having same
A coating holder for holding a plurality of workpieces includes a rotating shaft, a first driving member, a plurality of hanging arms, a plurality of supporting trays, and a plurality of second driving members. The first driving member is configured for driving the rotating shaft to rotate. The hanging arms extend from the rotating shaft. Each hanging arm includes a free end distal from the rotating shaft. The supporting trays are configured for holding the workpieces. The second driving members are fixed in the respective free ends and are connected to the respective supporting trays. The second driving members are configured for driving the supporting trays to rotate.
US08545630B2 Coating apparatus
A coating apparatus includes a chamber device and a transporting device. The chamber device defines two coating chambers, two parallel coating channels, and a transportation channel communicating with the coating channels. The coating chambers are separated from each other. The coating chambers and the coating channels are alternately arranged. Each coating chamber defines at least one coating slot communicating with the respective coating channel. The transporting device includes a shaft rotatable with respect to the chamber device and a carrying board fixed on the shaft. The shaft is axially movable in the transportation channel. The carrying board is receivable in each of the coating channels for exposing a substrate to the corresponding coating chamber via the associated coating slot. The carrying board is rotatable about the shaft in each of the coating channels and jointly movable with the shaft in and along the transportation channel between the coating channels.
US08545623B2 Method and apparatus for controlling the growth process of a monocrystalline silicon ingot
The present invention provides a method and apparatus for controlling the growth of a silicon ingot in which the diameter of the growing silicon ingot can be accurately measured. A camera captures an image of the interface ring between the growing silicon ingot and the silicon melt. An image processor extracts local intensity maxima from the captured image, which are then digitized into an image data which comprises attributes of the pixels forming the local intensity maxima. An analyzer statistically analyzes the image data to derive parameters of an equation statistically simulating the interface ring. A probabilistic filter conducts the statistical analysis on the equation in which the respective pixels are weighted by their weight factors. The weight factor functions to attenuate the effect of noises caused by pixels which do not represent the interface ring. The statistical analysis may be repeated, using the renewed parameters, to progressively attenuate the effect of the noises to thereby obtain a satisfactorily accurate diameter of the silicon ingot.
US08545622B2 Annealed wafer and manufacturing method of annealed wafer
An annealed wafer in which oxygen precipitation is uniform in the substrate plane and a manufacturing method thereof are provided. A nitrogen-doped silicon single crystal substrate pulled at the cooling rate of 4° C./minute or more during crystal growth between 1100 and 1000° C. wherein the nitrogen concentration is 1×1014 to 5×1015 atoms/cm3 and V/G satisfies predetermined conditions serves as a substrate, and the substrate is subjected to heat treatment in a non-oxidative atmosphere.
US08545611B2 Release agent formulas and methods
A release agent and method for using the same is provided. The release agent may have a high viscosity and gravity measurement and allowing for incorporation of a plurality of alternative oils and greases to be used as coating agent. Additionally, the release agent is adaptable for multiple uses by an end user as a coating agent without the need for reapplication of the release agent after every use. Moreover, the release agent may have additives such as anti-oxidants, preservatives, and emulsifiers that may allow for longer shelf life, easier coating and the like. Still further, the release agent may incorporate coloring and fragrances to make the agent more user friendly and easier to identify for coating purposes by the end user. The release agent may also incorporate freezing point depressants, anti-oxidants, emulsifiers, fragrances and solvent additives to increase shelf life and efficacy of the release agent.
US08545610B2 Fuel vapor treating apparatuses having a high thermal conductive honeycomb core
An adsorbent canister has a housing defining an adsorption chamber therein, an adsorbent filled in the adsorption chamber, and a honeycomb core. The honeycomb core is made from a material having a higher thermal conductivity than the adsorbent, defines therein a plurality of cells passing through the honeycomb core and is disposed in the adsorption chamber. The adsorbent canister can further have a heater for heating the honeycomb core or the honeycomb core can be made from a material, which produce heat when current is applied.
US08545609B2 Microwave reactivation system for standard and explosion-proof dehumidification system
The Microwave System and method of reactivation is designed to provide an indirect, safe and energy efficient source of heat and temperature rise required in the reactivation section of the desiccant unit for the release into atmosphere of the water vapors which are accumulated in the desiccant rotor. This microwave reactivation system and method is based on heat transfer produced from a heated fluid which is pumped through a closed loop coil assembly. This closed loop coil assembly is located and runs through both the isolated heating chamber of the microwave section and the reactivation / regeneration section in the dehumidification system. The airstream passing through the reactivation intake section comes in contact with the coil assembly and is heated to the desired temperature prior to reaching the desiccant rotor.
US08545606B2 Treatment of molecular sieve particles for mixed matrix membranes
The present invention relates to a method for treating molecular sieve particles for use in a mixed matrix membrane useful in, for example, gas separations. Membranes employing treated molecular sieve particles may exhibit enhanced permeabilities and selectivities in regard to, for example, the separation of carbon dioxide and methane.
US08545602B2 Removal of CO2, N2, and H2S from gas mixtures containing same
The removal of one or more of the gases CO2, N2 and H2S from gas mixtures containing at least one of said gases with use of an 8-ring zeolite having a Si:Al ratio from about 1:1 to about 1000:1. The preferred gas mixture is a natural gas feedstream and the preferred 8-ring zeolite is DDR.
US08545599B2 Electrohydrodynamic device components employing solid solutions
A thermal management apparatus includes an electrohydrodynamic fluid accelerator in which an emitter electrode and another electrode are energizable to motivate fluid flow. One of the electrodes includes a solid solution formed of a solvent metal having a first performance characteristic and a solute material having a second performance characteristic. The first and second performance characteristics are exhibited substantially independently in the electrode as the solvent metal and solute material remain substantially pure within the solid solution. A method of making an EHD product includes providing an electrode with such a solid solution and positioning the electrode relative to another electrode to motivate fluid flow when energized.
US08545589B2 Filtration media pack, filter element, and methods
A filtration media pack is provided having a plurality of layers of single facer media. The layer of single facer media includes a fluted sheet, a facing sheet, and a plurality of flutes extending between the fluted sheet and the facing sheet and having a flute length extending from a first face of the filtration media pack to a second face of the filtration media pack. A first portion of the plurality of flutes are closed to unfiltered fluid flowing into the first portion of the plurality of flutes, and a second portion of the plurality of flutes are closed to unfiltered fluid flowing out of the second portion of the plurality of flutes so that fluid passing into one of the first face and the second face of the media pack and out the other of the first face and the second face of the media pack passes through media to provide filtration of the fluid. The filtration media pack can be provided with increased filtration media compared with commonly used z-media packs. Techniques for increasing the amount of filtration media available for filtration include increasing the flute density, reducing masking, adjusting flute width height ratio, increasing flute density, adjusting flute shape, and reducing plug length. Techniques for increasing performance while reducing initial pressure drop are also provided. A filter element containing the filtration media pack is provided, and the filter element includes a seal member extending around a periphery of the filtration media pack. A method for manufacturing a filtration media pack and a method for using a filtration media pack are provided.
US08545587B2 Multi-phase filter medium
Multi-phase filter media, as well as related articles, components, filter elements, and methods, are disclosed.
US08545582B2 Abrasive articles including fused zirconia alumina grain having an improved shape
A coated abrasive article includes a backing and fused alumina-zirconia abrasive grains attached to the backing with a binder. The fused alumina-zirconia abrasive grains include between about 35 wt % and about 45.5 wt % ZrO2+HfO2, between about 43.7 wt % and about 65 wt % Al2O3, less than about 0.8 wt % SiO2 and less than about 10 wt % other oxides. The fused alumina-zirconia abrasive grains simultaneously satisfy both a granulometric and densimetric condition.
US08545579B2 Gasification furnace structure in gasification facility
A gasification furnace 2 is divided into a plurality of gasification furnace units 2a and 2b each of which has an inlet 15a, 15b on a lower portion at a longitudinally upstream end in a direction of travel of raw and bed materials and has an outlet 16a, 16b on an upper portion at a longitudinally downstream end in the direction of travel. The outlet 16a is connected to the inlet 15b. The inlet 15a is fed with a raw material and a hot bed material from a materials separator 8. The inlet 15b is also fed with the hot bed material from the material separator 8. The outlet 16b is connected to a combustion furnace 5.
US08545574B2 Methods for treating fibrous structures
Methods for treating a fibrous structure in need of treatment with a chemical additive, such as a chemical softener, and products produced therefrom, are provided.
US08545573B2 Spiral occluding device with an occlusion sail
An occluding device designed for occlusion of fluid flow through a body cavity is disclosed. The device comprises a coil having a proximal portion and a distal portion extending longitudinally from the proximal portion. The coil has an initial tension along the distal and proximal portions and is configured have a general helical shape in an expanded state. The device further comprises a first set of fibers attached to the coil and extending therefrom for occlusion of the body cavity. The device further comprises a second set of fibers attached to the coil at a plurality of areas longitudinally along the coil, defining an occlusion sail disposed longitudinally along the coil at the plurality of areas therealong. The second set of fibers is configured have the general helical shape when the coil is in the expanded state for enhanced occlusion of the body cavity.
US08545572B2 Subtalar implant
One embodiment of the invention includes a sinus tarsi implant with an inverted thread profile having a lip or lips at the thread crest. The lips may help hold tissue in-growth and give greater purchase to the implant. The implant may also include voids that traverse threads. The voids may create an open area for soft tissue to grow into. The voids may be relatively small and consequently promote faster tissue in-growth. Thus, the lips and/or voids limit migration. They do this without creating sharp edges or pressure points (or at least limiting such creation) that are typically associated with techniques (e.g., cutting deep negative thread spaces) used to prevent migration. Therefore, the embodiments of the invention limit migration while also limiting patient discomfort. Other embodiments are disclosed.
US08545571B2 Stabilized knee prosthesis
A knee prosthesis includes a femoral component, a tibial component, and a coupling component interconnecting the femoral component and the tibial component. The tibial component includes ball. The femoral component is configured to move relative to the tibial component. The coupling component defines an internal cavity including a first spherical end portion and a second spherical end portion. The internal cavity is dimensioned to receive the ball of the tibial component. The ball is repositioned between the first spherical end portion and the second spherical end portion of the internal cavity upon movement of the femoral component relative to the tibial component.
US08545570B2 Hinged joint system
Methods, systems, and devices for replacement of a joint with a prosthetic system that replicates the natural kinematics of the joint is disclosed. A prosthetic system according to one embodiment includes a tibial component having a tibial plateau and a tibial stem portion, the tibial plateau having a top side and a bottom side, a tibial insert, with a bearing surface, adapted to be positioned on the top side of the tibial plateau, a femoral component having a base portion and a central housing, the femoral component having an axis of extension-flexion rotation, the base portion having a pair of condyles, a mechanical linkage component linking the tibial component with the femoral component and with the tibial insert in between the tibial component and the femoral component, so that there is a center of contact between the condyles and the bearing surface, the mechanical linkage component adapted to allow the center of contact to move posteriorly during flexion, provide for the movement of the axis of extension-flexion rotation in the superior-inferior direction, and allow rotation of the tibial component, the bearing surface, and the femoral component about a superior-inferior axis in order to provide and control the natural kinematics of the knee joint.
US08545569B2 Patient selectable knee arthroplasty devices
Disclosed herein are methods and devices for repairing articular surfaces in a knee joint. The articular surface repairs are customizable or highly selectable for each patient and geared toward providing optimal fit and function. Kits are also provided to enable customized repairs to be performed.
US08545568B2 Method of using instruments and interbody spinal implants to enhance distraction
A method of using an interbody spinal implant by implanting the spinal implant into a patient in need of the spinal implant. The method includes accessing the disc space of the patient and locating the center of the disc space. The disc space is incised by making a window in the annulus of the disc space for insertion of the spinal implant. The endplates are cleaned of all cartilage and the disc structure, which is encapsulated by the annulus, is removed while avoiding damage to the endplate structure of the vertebrae. Optionally a size-specific rasp is selected and the disc space is cleared of all soft tissue and cartilage. Optionally the disc space is distracted by sequentially expanding it with distractors of progressively increasing heights. A spinal implant having a pre-determined size sufficient to balance frictional fit and elongation of the annulus is selected and seated in the disc space.
US08545566B2 Articulating spacer
Spinal implants are disclosed. One spinal implant includes a support body, an articulating element, a blocking member and a motion limiting member. The support body includes a superior end surface and a lower end surface having teeth. In between the superior end surface and the lower end surface is a recess formed in a sidewall of the support body for receiving the articulating element. The blocking member can be received in the recess to prevent inadvertent back-out of the articulating element from within the recess. The articulating element can articulate in one or more directions, thereby allowing articulation of the spinal implant into a desired position within a disc space.
US08545561B2 Orthopaedic medical device
An artificial disc having a pair of opposing plates (100) for seating against opposing vertebral bone surfaces separated by an inner stress distributor and spacer device (300) called in this specification a supporting element, functioning as both a spacer and structural support. Various plate geometries are disclosed including ones with flat outer faces and ones with convex outer faces to conform to the adjacent vertebral mating surface geometry. Inner surfaces are described as comprising two sloping substantially flat or curved surfaces meeting at an ridgeline with a radius. Various inner device embodiments are disclosed including circular ones and non-circular ones, plate flat ones, ones with a raised rim or circular recess, ones with raised hubs and ones with an elastomeric planar core to perform a shock-absorbing function, ones with central bore and ones with no central bore. Inner spacers comprising various combinations of these features are disclosed. The inner spacer/support devices are dispersed between the plates, through various disclosed couplings, so that the plates compress, rotate and angulate freely relative to one another, enabling the artificial disc to mimic a healthy natural intervertebral disc.
US08545558B2 Flipping-type graft fixation device and method
A buckle useful for cortical fixation has a graft retention loop slidably affixed thereto for movement from a first position adjacent a first end of the buckle to a second position at about the midpoint of the buckle. The buckle, with a graft over the loop, is drawn up lengthwise through a bone tunnel through a tibia and then flipped sideways to rest against the surface of the bone with the loop and graft depending back into the tunnel. The sliding attachment of the loop permits flipping of the buckle minimizes the flipping distance, which is the excess amount of the loop which must be pulled free of the tunnel to allow the buckle to be flipped sideways.
US08545556B2 Capsular intraocular lens implant
An intraocular lens having a light-transmitting optic (32, 94a, 94b, 142, 148, 216) comprised of a synthetic light-refractive material (40, 102) operably coupled with a flexible optic positioning member (34, 62, 74, 84, 100, 150, 210) to refract light onto the retina in order to correct refractive errors in the eye (10). The refractive material has an index of refraction of from about 1.36 to 1.5 or higher. The optic positioning member (34, 62, 74, 84, 100, 150, 210) is constructed of a flexible synthetic resin material such as polymethylmethacrylate and permits focusing upon objects located near to and far from the viewer. The optic (32, 94a, 94b, 142, 148, 216) of the present invention possess greater refractive capability than optics conventionally used in IOL construction, and permits retinal receipt of the image being viewed in order to correct refractive errors.
US08545548B2 Radiopaque markers for implantable stents and methods for manufacturing the same
Radiopaque markers for use with stents implantable within a body vessel are provided with one or more through-holes. Each through-hole extends through the thickness of the marker to expose a portion of the stent underlying the marker. The marker is welded to the stent through each through-hole. Also provided are stents incorporating a radiopaque marker having one or more through-holes suitable for receiving a weld. Methods are provided for securing a radiopaque marker having one or more through-holes to a stent.
US08545547B2 Expandable slide and lock stent
An expandable slide and lock stent is provided that comprises a plurality of radial elements interconnected to form a tubular member. Each radial element can comprise a helical backbone and at least one elongate member extending from the helical backbone in a circumferential direction. Each backbone can have at least one slot that can be configured to receive an elongate member of an adjacent radial element.
US08545546B2 Bioabsorbable scaffolds made from composites
Bioabsorbable scaffolds made at least in part of a poly(L-lactide)-based composite are disclosed. The composite includes poly(4-hydroxybutyrate) or poly(L-lactide)-b-polycaprolactone block copolymer, which increases the fracture toughness or fracture resistance of the scaffold. The composite can further include bioceramic particles, L-lactide monomer, or both dispersed throughout the composite. The bioceramic particles improve the radial strength and stiffness of the scaffold. The L-lactide monomer is used to control the absorption rate of the scaffold.
US08545544B2 Delivery catheter with constraining sheath and methods of deploying medical devices into a body lumen
A delivery catheter includes a constraining sheath coupled to a distal end of the catheter, and a medical device, such as an embolic protection device (EPD) or a stent, constrained by the sheath. A wire may extend proximally from the constraining sheath and be coupled thereto. A proximal pulling force on the wire causes the wire to tear the constraining sheath, thereby releasing the medical device from a constrained configuration to an expanded configuration.
US08545543B2 Methods and apparatus for microstructure lightguides
This invention may be implemented as a microstructure probe for delivering light of variable color and/or power, via a set of integrated lightguides, from an optical source (or set of sources) to regions spatially arranged 3-dimensionally, with a length scale of microns to millimeters. In exemplary embodiments of this invention, a microstructure probe comprises many lightguides and is adapted to be inserted into neural or other tissue. The lightguides run in parallel along at least a portion of the axis of the probe. The probe may deliver light to many points along the axis of insertion of the probe. This invention may be implemented as an array of two or more such probes (each of which comprises multiple lightguides). This array may be used to deliver light to neural tissue in a complex 3D pattern.
US08545542B2 Tanning device and method therefor
A tanning device has one or more reflective surface areas. The reflective surface areas may be used for redirecting light rays toward one or more parts of a user's body. A pair of speakers are positioned in the tanning device.
US08545541B2 System and method for wire-guided pedicle screw stabilization of spinal vertebrae
An improved system and method for positioning screws and rods to immobilize bones is provided. Specifically, the system and method is optimal for performing transforaminal lumbar interbody fusion (TLIF) and other interbody fusions in the spine. The system involves pedicle screws detachably connected to wires that guide rods down to the screws. The wires are strong, narrow, flexible, adjustable in tension, and easily disconnected from the screws after rod placement via a process such as cutting, radiating, burning, dissolving, etc.. The use of wires to place the rods avoids the conventional bulky tower apparatuses of the prior art while at the same time enhancing the accuracy of placement. One of the preferred methods involves relying upon the natural lordotic curvature of the spine and the narrow diameter of the wires to insert many elements through a single minimally invasive incision.
US08545539B2 Proximal humeral fracture reduction and fixation device
An apparatus and method for reducing and fixing fractures, for example, a proximal humeral fracture. A jacking device releasably attached to a locking plate presses against an inferior aspect of the head to rotate the head into anatomic alignment. Suture material stitched into the soft tissue superior to the head pulls the superior end of the head and guides and steers the head. The suture material passes through suture holes in the superior end of the plate. The jacking device positions and holds the head in an anatomic neck/shaft angle, thereby allowing the head to be fixed to the locking plate. In one such embodiment, a swivel bushing in the plate receives the jacking device and allows the angle of the device to be adjusted as desired. To aid in the fluoroscopic visualization during surgery, a radiolucent retractor is used to avoid blocking the surgeon's view.
US08545537B2 Developmental pacifier
A Developmental Pacifier is provided to help infants with functional feeding development and to assist with specific developmental problems in young children such as developmental delays, prematurity, gastro-esophageal reflux, autism spectrum disorder, hypotonicity, cerebral palsy, Down's syndrome, microcephaly, and other sensory integrative dysfunctions. The developmental pacifier of the present invention encourages acceptance of food textures and stimulates oral-motor awareness, and reduces or eliminates functional feeding problems in children. The Developmental Pacifier has a nipple with an upper portion and a base portion, a base, and sensory elements. A series of Developmental Pacifiers with varying sensory elements may be used for certain treatment regimens as prescribed by a medical practitioner, pediatric occupational therapist, or other pediatric specialist.
US08545531B2 Guidewire and method for surgical procedures
A surgical guide wire or K-wire and method of use are provided. The K-wire, or guide wire, has opposite end portions and a shank portion in between. One end portion has a deformable end portion that, once outside of a confining guide passage, can be deformed to present a projected forward facing area that is larger than the transverse cross section of the K-wire, or guide wire, while in the passage. The increased area will provide increased resistance to additional forward axial movement into the surgical site.
US08545530B2 Implantable aneurysm closure systems and methods
An implantable closure structure is delivered using minimally invasive techniques and inhibits the migration of liquid and particulate matter from inside a physiological cavity or opening, such as an aneurysm, as well as inhibiting the flow of liquid and particulate matter, such as from an associated blood vessel, into a physiological cavity or opening. The device has a flexible patch supported by a framework structure that covers the neck or opening of a cavity such as an aneurysm and may have anchoring structures for supporting the flexible patch in place across the opening.
US08545527B2 Control for a powered surgical instrument
A surgical instrument is provided for cutting bone and other tissue. The instrument includes a housing. A plurality of sensors is located in the housing in a spaced apart orientation from each other. A collar is moveably mounted to the housing into a plurality of different collar orientations on the housing. A lever comprising an actuator is moveably coupled to the collar and, with the collar located in any one of the plurality of different collar orientations, the lever is operable to move the actuator relative to one of the plurality of sensors in order to vary a signal produced by that sensor.
US08545523B2 Tissue repair method and kit
A method for tissue repair including providing a kit including a mesh placer, mesh stitcher and mesh tacker, placing the mesh at a tissue repair site with the mesh placer, holding the mesh in place with the mesh placer, and fastening the mesh to tissue with at least one of the mesh tacker and mesh stitcher.
US08545520B2 Tissue suturing method
A method of suturing tissue includes engaging tissue with a suturing head, driving a needle from a proximal end portion of the suturing head through the tissue, and engaging a capsule disposed in a distal end portion of the suturing head with the needle, the capsule comprising a length of suture attached thereto.
US08545519B2 Medical devices with detachable pivotable jaws
Medical systems, devices and methods are provided for engaging tissue, e.g. for clipping tissue, closing a perforation or performing hemostasis. Generally, the medical system including a housing, first and second jaws rotatable relative to the housing, a driver, and an elongate drive wire. The elongate drive wire may be disconnected from the driver, first and second jaws, and the housing, which are left in vivo engaged with the tissue.
US08545518B2 Hybrid epilator device
The present invention is a hybrid epilator device comprising an epilation unit for gripping and plucking hairs from a skin surface and at least one razor blade edge to shave off hairs growing on the skin surface. The blade edge defines a use direction along which it is effectuated that hairs are shaved off when the razor blade is drawn over the skin surface during operation. The razor blade is arranged behind the epilation unit with respect to the use direction. The epilation unit and the razor blade are mounted for simultaneous contact with the skin surface, where during operation the epilation unit grips and plucks out hairs from the skin surface and subsequently the razor blade shaves off remaining hairs growing on the same skin surface in a single stroke.
US08545516B1 Waterproof motorized device having rotating dermabrasion apparatus to peel calluses and hardened skin cells from locations on a person's foot
A device including a body having a bottom wall and a cover including a top wall and a sidewall which enclose an interior chamber so that the interior chamber is waterproof to enable the device to be placed in an enclosure where water comes in contact with the device, the interior chamber housing a mechanism by which a shaft or axle supporting a dermabrasion wheel is caused to rotate, the body further including an activation member which when activated causes the shaft and the dermabrasion wheel to rotate in either a counterclockwise direction or a clockwise direction, so that the dermabrasion wheel will peel hardened skin cells from a location on a foot when the location on the foot is placed against the dermabrasion wheel while the dermabrasion apparatus is rotating.
US08545514B2 Monorail neuro-microcatheter for delivery of medical devices to treat stroke, processes and products thereby
Devices, processes and systems facilitate and enable treatment of acute stroke conditions, providing reperfusion while therapy is made available by preserving structure in the arterial tree. Using a Rapid Exchange approach with at least dual lumens in a microcatheter facilitates embolus/clot removal without damaging sensitive vasculature.
US08545511B2 Expandable reverse shoulder trial
Described herein is an expandable shoulder trial for a reverse shoulder system including a rotatably adjustable insert housed within a humeral cup. The insert has proximal and distal ends, the proximal end having a concave recess therein adapted to receive a glenosphere prosthesis. The distal end of the insert includes a shaft, the shaft having a helical groove disposed on at least a portion thereof. A distal end of the humeral cup is inserted in a humeral stem. The humeral cup has a proximal end including a recess therein, the recess defined by a circular wall. A guide pin protrudes from the circular wall and is adapted to engage the helical groove of the insert shaft. The proximal end of the insert may rotate along an axis toward the proximal end of the humeral cup and along the same axis away from the proximal end of the humeral cup.
US08545508B2 High tibial osteotomy guide
A cutting block for use in a bone osteotomy procedure is disclosed, and includes a first cutting guide surface, a second cutting guide surface, and a third cutting guide surface. The first, second, and third cutting guide surfaces are adapted to be temporarily affixed to a bone having a first side and a second side such that the first cutting guide surface is disposed on the first side of the bone, and such that the second cutting guide surface and third cutting guide surface are disposed on the second side of the bone forming an angle therebetween.
US08545507B2 Prosthesis removal cutting guide, cutting tool and method
A kit (10) for removal of bone (12) adjacent to an implanted prosthesis (14), said kit (10) comprising: a guide (16) for cooperation with the prosthesis (14); and a tool (20) constrainable by said guide (16) for removal of the bone (12).
US08545500B2 Bone fixation assembly
A fixation assembly and methods for its use are provided. The fixation assembly includes two or more fixation elements, at least one connection means adapted to engage with the fixation elements to connect them to one another, and a locking means that is actuated after engagement of the fixation elements with the connection means to simultaneously lock the fixation elements in place relative to one another and to the connection means.
US08545498B2 Cardiac ablation devices and methods
Devices and methods provide for ablation of cardiac tissue for treating cardiac arrhythmias such as atrial fibrillation. Although the devices and methods are often used to ablate epicardial tissue in the vicinity of at least one pulmonary vein, various embodiments may be used to ablate other cardiac tissues in other locations on a heart. Devices generally include at least one tissue contacting member for contacting epicardial tissue and securing the ablation device to the epicardial tissue, and at least one ablation member for ablating the tissue. Various embodiments include features, such as suction apertures, which enable the device to attach to the epicardial surface with sufficient strength to allow the tissue to be stabilized via the device. For example, some embodiments may be used to stabilize a beating heart to enable a beating heart ablation procedure. Many of the devices may be introduced into a patient via minimally invasive introducer devices and the like. Although devices and methods of the invention may be used to ablate epicardial tissue to treat atrial fibrillation, they may also be used in veterinary or research contexts, to treat various heart conditions other than atrial fibrillation and/or to ablate cardiac tissue other than the epicardium.
US08545496B2 Catheter with remotely extendible instruments
A method for performing a surgical procedure within lungs of a patient. The method comprising the steps of providing a plurality of surgical instruments and providing a housing. Attaching a flexible, elongated shaft with distal and proximal ends to the housing. Engaging at least one working end to the distal end of the housing, the working end including a plurality of tubes disposed therein that define a corresponding plurality of working channels for housing a corresponding plurality of surgical instruments. Controlling an actuator to engage at least one of the corresponding plurality of surgical instruments, wherein rotation of the working end with respect to a longitudinal axis of the elongated shaft engages at least one of the plurality of surgical instrument with the actuator to deploy the at least one surgical instrument to the lung as needed during a surgical procedure.
US08545490B2 Apparatus, a method and a computer program for applying energy to an object
The present invention relates to an apparatus (1) for applying energy to an object (2), wherein the apparatus (1) comprises an energy emitting element, a temperature sensor and a tube (6), in which the energy emitting element and the temperature sensor are locatable. The energy emitting elements is adapting for applying energy to the object (2) and the temperature sensor is adapted for sensing the temperature of the object (2). Both, the energy emitting element and the temperature sensor can be guided to a location of the object (2), at which the energy is to be applied.
US08545489B2 Method and apparatus for skin reduction
A method for reducing skin is disclosed, in which a plurality of incisions or removals are made to collectively form a patch of skin to be reduced, instead of making a single large treatment of the patch. Thus, scarring after healing is less noticeable. Preferably, the treated regions of skin are arranged such that a total area of all removed skin segments taken in a direction perpendicular to an axis of said patch changes gradually along said axis. The removed regions of skin are preferably navicular in shape, and the patches are preferably navicular in shape in the event an elongated incision is made. The removal of skin regions can be realized by proper treatment methods such as incisions and laser treatment. The mask may be attached to the patch of skin to be treated after said skin is stretched.
US08545476B2 Assembly to facilitate user reconstitution
A reconstitution assembly includes a housing including a lower sleeve and an upper sleeve, including a first container and a second container disposed vertically opposite the first container. A transfer set assembly is disposed within the housing between the first container and the second container. The transfer set assembly includes an upper spike housing and a lower spike housing, with a flow path defined through the upper spike housing and the lower spike housing. The transfer set assembly is configured to access contents of the first container and then upon the activation of a triggering mechanism, create a fluid pathway between the first container and the second container. The triggering mechanism includes trigger fingers which ensure the transfer set assembly sequentially accesses the contents of the first container before accessing the contents of the second container. The disposition of the first container activates the triggering mechanism.
US08545475B2 Coupling component for transmitting medical substances
A coupling component is disclosed for transmitting medical substances, comprising two channels for conveyance of medical substances in two substantially opposite directions and a means for releasable connection to a second coupling component having a further channel for creating a coupling. The connecting means is a thread. A method for conveying medical substances to and from a container is also disclosed.
US08545473B2 Wearing article with corrugated fasteners
A wearing article having a front waist region provided along a pair of opposite side edges with first fastening members, and a rear waist region provided along a pair of opposite side edges with second fastening members adapted to be engaged with the associated first fastening members. Each of the second fastening members is formed with an uneven structure having a plurality of crests extending in a transverse direction and spaced one from another in a longitudinal direction. A degree of engaging force between the uneven structure and the first fastening member is extremely weak and the uneven structure can be easily disengaged from the first fastening member. The uneven structure may be unfolded in the longitudinal direction and put in close contact with the first fastening member to achieve firm engagement over an area as large as possible between the flattened uneven structure and the first fastening member.
US08545472B2 Absorbent product having a middle elastic member
In a pants-type absorbent product, a first middle elastic member is located along a horizontal direction in a middle front part between a pair of leg openings in an outer covering sheet. The first middle elastic member contracts a first sheet and a second sheet, and middle gathers are formed. Thus, it is possible to improve fitting of a middle part to a wearer. In the middle front part, both ends of the first middle elastic member are apart from edges of the pair of leg openings, and a pair of non-contracted parts are provided between the both ends of the first middle elastic member and the edges of the pair of leg openings, to thereby improve flexibility of portions in the vicinities of the leg openings in the outer covering sheet.
US08545471B2 Array of disposable absorbent articles having a sequence of graphics corresponding to a wearer's stages of development
An array of disposable absorbent articles comprising a sequence of graphic designs corresponding to a wearer's stage of development. For a disposable diaper, the array of disposable absorbent article graphic designs may comprise a first absorbent article graphic design for newborns and infants, a second absorbent article graphic design for toddlers, and a third absorbent article graphic design for older wearers, and other absorbent article graphic designs.
US08545469B2 Component for securing attachment of a medical device to skin
A component for securing attachment of a medical device, such as a wound dressing or an ostomy bag is disclosed, to the skin of a patient, said component including a first plastic film coated with a skin-friendly adhesive on the lower side thereof. According to the invention a body of soft, compressible and elastic material is disposed between the first plastic film and a second plastic film, said first and second films extending beyond the compressible body around the circumference thereof and are affixed to each other in parts extending around the circumference of the compressible body so that a closed space containing said compressible body is formed, said closed space being in contact with the surrounding atmosphere by a non-return valve, and in that the first plastic film includes through-going openings in a region delimited by the compressible body.
US08545468B2 Component for forming a seal around an opening in the skin
A component is suitable for protecting skin around an opening in the skin or around a stoma. The component can be formed from a carrier (2; 2′) that is enclosed between layers of soft and skin-compatible adhesive (3; 3′), and the adhesive has a softness of 8-22 mm. The adherence of the adhesive to dry skin can be 0.2-3 N/25 mm.
US08545464B2 Reduced pressure treatment system
A wound treatment apparatus is provided for treating tissue damage, which comprises a fluid impermeable wound cover sealed over a site for purposes of applying a reduced pressure to the site. The apparatus also can include a cover with protrusions on its surface for purposes of monitoring pressure at the site. One or more sensors can be positioned under the cover to provide feedback to a suction pump controller. The apparatus can have a miniature and portable vacuum source connected to the wound cover.
US08545462B2 Patch for irrigation/aspiration tip
In various embodiments, an ophthalmic surgical instrument may include an aspiration tube, an irrigation/aspiration tip (formed of a first material such as plastic), and a patch, coupled to the irrigation/aspiration tip, made of a second material (e.g., silicone) having a higher coefficient of friction than the first material. In some embodiments, the patch may be placed on the irrigation/aspiration tip in a position to allow a user of the irrigation/aspiration tip to manipulate an intraocular lens (IOL) through contact between the patch and the IOL. For example, the patch may be positioned on a side of the irrigation/aspiration tip opposite an aspiration port or on a distal end of the irrigation/aspiration tip. In some embodiments, the patch may be formed separately and coupled to the irrigation/aspiration tip through an adhesive or may be molded onto the irrigation/aspiration tip. In some embodiments, the patch may include features to increase friction.
US08545460B2 Infusion apparatuses and related methods
Assemblies for identifying a power injectable vascular access port are described. One assembly includes a vascular access port, a first identifiable feature, a second identifiable feature, and a third identifiable feature. The first identifiable feature is incorporated into the access port and identifies the access port as suitable for flowing fluid at a fluid flow rate of at least 1 milliliter per second through the access port. The second identifiable feature is incorporated into the access port and identifies the access port as suitable for accommodating a pressure within the cavity of at least 35 psi. The third identifiable feature is separated from the access port and confirms that the implanted access port is both suitable for flowing fluid at a rate of at least 1 milliliter per second through the access port and for accommodating a pressure within the cavity of at least 35 psi.
US08545459B2 Stabilized enzyme compositions
A medical device includes a base material having an immobilized fibrinolytic enzyme and dextran sulfate. The dextran sulfate has a molecular weight that is less than 40 kilo dalton (kDa). The medical device is formed from at least a base material. A fibrinolytic enzyme is immobilized on the base material. The fibrinolytic enzyme is stabilized with a dextran sulfate having a molecular weight of less than 40 (kDa).
US08545458B2 Pinch clamp assembly for an infusion cassette
A pinch clamp assembly for engaging a tube with an enteral feeding or infusion pump adapted to feed nutritionals or to infuse medical solutions to a patient, is provided comprising a base (1) comprising holding means (3) for holding a pumping section (10) of the tube in operative engagement with the base (1) and supporting means (5) for supporting a connector (6), a clamping element (7) having clamping surfaces engageable with the pumping section (10) and moveable between an open position allowing flow of fluid through the pumping section (10) and a closed position, a cover element (8) for slidable engagement with the clamping element (7) and the connector (6), the cover element (8) being removable from the pinch clamp assembly, wherein the cover element (8) is mountable to or dis-mountable from the clamping element (7) and the connector (6) only when the clamping element (7) is in the closed position, wherein in the mounted position of the cover element (8) the clamping element (7) can be brought into the open position and the connector (6) cannot be removed from the assembly.
US08545457B2 Sprayer
A sprayer which inhibits or prevents clogging from occurring in a nozzle when a liquid is ejected from the nozzle includes a nozzle having a first internal tube through which a first liquid passes, and a second internal tube through which a second liquid passes. An external tube is provided in which the first internal tube and the second internal tube are positioned so that the gas passes therebetween. In the sprayer, each distal end part of the first internal tube and the second internal tube includes a gas permeable film impermeable to each liquid, and permeable to the gas.
US08545456B2 Administering apparatus comprising a rotational block
An administering apparatus including a rotational block which, in the end position of the dosage setting member, permits the rotational dosing movement in a first rotational direction and blocks the rotational dosing movement in a second rotational direction, wherein the rotational block comprises at least one first rotational stopper and at least one second rotational stopper, the first rotational stopper and the second rotational stopper abutting against one another in the end position of the dosage setting member, wherein the at least one first rotational stopper is secured against rotating by the dosage setting member and the at least one second rotational stopper is secured against rotating by the casing.
US08545455B2 Needle shield for injections
A needle shield for hiding a needle from a patient during an injection is disclosed. The needle shield comprises an attaching portion for attaching the needle shield to a syringe and an opaque collapsible element extending from the attaching portion, the collapsible element having an orifice extending therethrough and being of a sufficient length to conceal a needle from view when the needle is disposed in the orifice, and wherein the collapsible element collapses and conceals the needle as the needle is inserted into a patient's skin and expands to retain its original shape as the needle is withdrawn from the patient's skin so that the patient does not see the needle during an injection.
US08545454B2 Needle tip guard for percutaneous entry needles
A needle tip protective device for use with percutaneous entry needles. In one embodiment, the needle tip protective device includes a needle guard slidably mounted on a hypodermic needle, the latter having a needle tip located at the distal end thereof, and a change of profile formed medially there along. The needle guard is movable along the hypodermic needle and engageable with the change in profile formed thereon. The engagement with the change in profile is configured to correspond with the ability of the needle trap to entrap the needle tip once the needle trap has advanced the sufficient distance distally along the hypodermic needle. In further refinements, the needle trap may be biased toward the distal needle tip of the needle.
US08545452B2 Covered suction device
A suction device which can protected before and after use. The suction device includes an elongated suction tube having a suction tip at one end. A retractable, protective sheath is connected to the tube and extends over the exposed length of the suction tube. A tip protector extends from the free end of the sheath, and includes an interference structure in the form of a plurality of spaced ribs protruding inwardly to engage and grip the suction tip. A hollow sheath housing is secured to the free end and a sheath inserter is secured to the suction tube proximate the connection end, with the sheath housing and the sheath inserter being shaped to insert the retractable sheath in the hollow sheath housing when the sheath is in a retracted position. The tip protector and the sheath housing can be portions of a unitary structure.
US08545447B2 Mechanical pump for removal of fragmented matter and methods of manufacture and use
Material transport catheters and methods for their use rely on rotation of an impeller within a catheter body and a clearing element for preventing buildup of materials at the opening of the catheter body. The impeller preferably comprises an inner tube or shaft having a helical rotor fainted over an outer surface thereof. The clearing element may comprise a free end of a structure near the distal end of the catheter body for disrupting clot, wherein the free end of the structure extends into the distal opening of the catheter body to break up materials as the impeller is rotated. Alternatively, the clearing element may comprise a cutting member disposed at the distal opening of the catheter body.
US08545442B2 Mechanically assisted inflation device handle
An inflation device including a handle mechanism configured to selectively engage and disengage threads within the device. In some instances the threads are configured to couple a plunger to a syringe body. The handle mechanism may be configured to (1) provide a mechanical advantage and (2) change the location and direction of the input force, thereby making the device easier to use.
US08545440B2 Injection system for delivering multiple fluids within the anatomy
Devices and systems for injecting fluids and/or other materials into a targeted anatomical location, in particular, a joint or intra-articular space, include a handpiece assembly having a needle extending from its distal end, a fluid delivery module comprising a cassette and a fluid transfer device. A conduit is generally configured to place the fluid delivery module in fluid communication with the handpiece assembly. Medicaments, formulations and/or other fluids or materials contained within vials that are secured to a cassette or other portion of the fluid delivery module can be selectively delivered into an anatomy through a needle located at the distal end of the handpiece assembly. In some embodiments, ultrasound or other imaging technologies can be used to locate a joint or other targeted anatomical location.
US08545434B2 Catheter port configuration
A catheter for use in the extracorporeal treatment of bodily fluids comprises a catheter body having a withdrawal port, an infusion port, and a plurality of lumens therein. One of the lumens comprises a withdrawal lumen for transport of fluids withdrawn from a body vessel through the withdrawal port to an extracorporeal treatment unit, such as a dialyzer. Another lumen comprises an infusion lumen for infusion of treated fluids from the extracorporeal treatment unit through the infusion port into the vessel. The withdrawal port is positioned proximally from the infusion port along a length of the catheter body, and includes a generally helical profile.
US08545433B2 Apparatus and method for treating spider veins
There is provided herein a system, device and methods for performing minimally invasive spider vein treatments. In some embodiments an apparatus for eliminating spider veins comprises a dual syringe mechanism that includes a pusher for pushing sclerosant materials into a target vein, and an extractor for extracting debris from a target vein; a needle for application into a target vein; and a Y-connector connecting each exit of the dual syringe mechanism to the needle. In some implementations the apparatus's dual syringe mechanism includes a locking mechanism to enable controlled advancing of the syringe pusher.
US08545426B2 System and method for controlling patient fluid balance and/or flow rate for a therapeutic plasma exchange procedure
Systems and methods for controlling fluid flow during a fluid exchange procedure. In one aspect, a system is provided for controlling a net fluid volume difference of a patient during and/or after a fluid exchange procedure. The system comprises a first flow path for flowing at least a first fluid from the patient and a second flow path for flowing at least a second fluid to the patient. First and second reservoirs are respectively associated with the first and second flow paths. A controller is associated with the first and second flow paths for controlling first and second flow rates and operable to determine an actual flow rate for each first and second fluid and to change a first or second flow rate in response to a difference between at least one of such flow rates and its respective actual flow rate.
US08545420B2 Methods and apparatus for rehabilitation and training
The invention relates to a rehabilitation device which guides a patient to perform a motion with a correct spatial trajectory, by the device applying one or more pushing, assisting, reminding, responding and/or resisting forces during a motion (or intent to move) by the patient. The forces are applied by an actuator, for example, a robotic articulated arm or a spherically jointed lever. The applied forces act as a force fields, optionally continuous, which impeded and/or guides a patient. The device can be programmable with various trajectories (paths and/or velocities) and/or forces. The forces at one point in the trajectory can vary responsive to an actual trajectory by the patient and/or responsive to a rehabilitation plan and/or improvement of the patient. The device can learn a motion entered by a physiotherapist and replay it for the patient.
US08545415B2 Portable alveolar gas meter
A portable alveolar gas measurement device and method of determining at least one alveolar gas level are disclosed. The device includes a structure that receives a sample portion of breath, and a gas sensor in communication with the structure that detects a gas level of a gas within the sample portion and provides a first signal indicative of the level. The device further includes circuitry coupled at least indirectly to the gas sensor, where the circuitry receives at least one of the first signal and a second signal related to the first signal, and where the circuitry provides at least some assistance in determining whether a portion of information provided by the at least one signal is used as an indication of an alveolar gas level. Additionally, the device includes an output device coupled to the circuitry that provides an output indicative of the first alveolar gas level.
US08545403B2 Medical device insertion
Devices and methods for inserting at least a portion of a medical device in a patient are provided. Embodiments include medical device insertions that employ a plurality of insertion stages. Also provided are systems and kits for use in analyte monitoring.
US08545394B2 Selective cannulation method for luminal tissue having branch section
A selective cannulation method for a lumenal tissue's branch section includes: a first step for guiding an endoscope having a channel to an aperture section of the lumenal tissue; a second step for inserting a distal end of an endoscopic treatment instrument through the channel into the aperture section of the lumenal tissue; a third step for having the distal end of the endoscopic treatment instrument make contact with a pipe wall extending from the aperture section of the lumenal tissue to the branch section at two opposed points on the pipe wall by deforming the distal end of the endoscopic treatment instrument; a fourth step for sliding and moving the distal end of the endoscopic treatment instrument to the branch section while having the distal end of the endoscopic treatment instrument make contact with the pipe wall; and a fifth step for inserting the distal end of the endoscopic treatment instrument into a predetermined branch lumen divided from the branch section.
US08545392B2 Sexual stimulation device
A sexual stimulation device which provides simultaneous stimulation to male and female partners during intercourse includes a hollow elastomeric shaft portion dimensioned to receive a penis and for vaginal insertion. The shaft includes a longitudinal rib forming an interior channel, the rib functioning to stiffen the shaft and the channel providing sufficient resilience to allow insertion and removal of a penis. The shaft terminates at a closed end in a hemispherical tip and at an opposite open end in a pair of spaced annular retaining rings. A plurality of raised rings spaced axially along the shaft enhance the pleasure of the female partner. The retaining rings provide a resilient retaining force to maintain the device in position during intercourse. An electric motor with an eccentric weighted flywheel mounted in a chamber extending between the annular rings provides vibratory stimulation. An electrical wire for powering the vibratory motor extends through a conduit connecting the chamber to an attached housing enclosing rechargeable batteries. The housing also includes a second motor operably connected for rotating caged massage balls positioned to provide simultaneous stimulation to a female partner during intercourse. An elastomeric shell encloses and substantially seals the housing, while still allowing user actuation of two HIGH-LO-OFF switches providing independent control of the two motors and connection of an AC adapter for recharging the batteries. In an alternative embodiment, the hollow shaft may be omitted.
US08545390B2 Sexual stimulation device
A sexual stimulation device comprises a casing (2) in which is contained a vibrator unit and connection means in the form of gripping limbs (6, 7) for holding the device to the penis. The connection means extend about the penis in a connection place (P) and a longitudinal axis (c) of the casing (2) is inclined to the connection plane (P) whereby, in use, the casing (2) extends along and away from the penis.
US08545385B2 Implantable reservoir body
An implantable reservoir body is provided which, as and when required, makes available a working medium that serves at least to inflate an implantable unit. An elastic hollow body is provided whose wall encloses a reservoir volume, and an induction coil arrangement is provided inside the reservoir volume and/or an induction coil arrangement is connected to the wall of the hollow body. The induction coil arrangement is connected to a pump/electronics unit provided inside or outside the hollow body, and a fluid channel is provided which leads out of the hollow body and which is connected to the pump unit and/or directly to the implanted unit that is to be inflated.
US08545384B2 Anal incontinence disease treatment with controlled wireless energy supply
A anal incontinence disease treatment apparatus and method include and use an operable restriction device implanted in a patient and engaging the colon or engaging the rectum to form a restricted fecal passageway in the colon or the rectum. A source of energy external to the patient's body and a control device for releasing wireless energy from the source of energy from outside the patient's body are provided. The released wireless energy is used in connection with the operation of the restriction device, to enlarge or contract the restricted fecal passageway.
US08545383B2 Light activated hearing aid device
The invention relates to a hearing aid device for humans with impaired hearing, who have an at least partially functional cochlea and a functional nervous signalling pathway from the cochlea via the auditory nerve to the brain. The hearing aid device contains a receiver, a transducer of the sound or other acoustic signals into electrical current serving as a signal representing a sound, a pulsed irradiation source connected to the transducer for receiving the electrical current and for generating modulated pulsed irradiation in dependence from the electrical current, and preferably one or more optical fibers optically coupled to the exit of the pulsed irradiation source, wherein the optical path for conduction of irradiation within the device ends directly opposite a functional element of the natural vibration transduction pathway, e.g. adjacent the skull, the tympanic membrane, the hammer, the incus, the stapes, the outside of the cochlea, the otic capsule, the round window membrane, or the oval window membrane.
US08545382B2 Method of balloon pumping and a balloon pump driving apparatus
A balloon pumping method of inflating and deflating a balloon includes the steps of setting a pressure in the balloon at a first pressure value, which is higher than a minimum pressure value and is substantially equal to or lower than a maximum pressure value, when the balloon is shifted from a deflated condition to an inflated condition, and setting the pressure in the balloon at a second pressure value, which is substantially equal to or higher than the minimum pressure value and lower than the first pressure value, when the balloon is estimated to have completely inflated at the first pressure value.
US08545381B2 Auxiliary artificial heart pump drive device and auxiliary artificial heart system
An auxiliary artificial heart pump drive device for driving an auxiliary artificial heart pump includes first and second pump control parts which are arranged in duplexed configuration. Each pump control part controls the auxiliary artificial heart pump by outputting a drive signal to the auxiliary artificial heart pump. Each pump control part has a means which, when a failure is detected in the pump control part, electrically cuts off a path through which the drive signal is outputted to the auxiliary artificial heart pump. According to the present invention, it is possible to provide an auxiliary artificial heart pump drive device and an auxiliary artificial heart system which exhibit high availability even when a serious failure occurs by any chance without duplexing a pump device.
US08545378B2 Systems and methods for inducing electric field pulses in a body organ
Systems and methods for providing controllable pulse parameter magnetic stimulation are described. One aspect is directed to a magnetic stimulation system for inducing approximately rectangular electric field pulses in a body organ, comprising an electrical energy storage device, a stimulating coil, and a switching means for electrically coupling said electrical energy storage device to said stimulating coil to produce current pulses in said stimulating coil which generates, in response to the current pulses, magnetic field pulses that can induce approximately rectangular electric field pulses in the body organ.
US08545377B2 Magazine for chain components for a chain with radiation sources and a system consisting of a chain component and a magazine for chain components for a chain with radiation sources
A magazine for chain components of a chain with radiation sources comprises a housing as well as a first means for receiving chain components that is mounted in a pivotal manner in the housing and has recesses for receiving the chain components, a tension spring for driving the means for receiving the chain components, a sprocket being coupled in a pivotal manner to the means for receiving the chain components and being mounted in a pivotal position in the housing, and an ejector for ejection of the radiation sources. Furthermore, the magazine comprises an ejection lever which is mounted in a pivotal manner in the housing, whereby, in a first position, the ejection lever engages the sprocket, and in a second position it blocks the ejector.
US08545376B2 Punched out tabs
A system and method are provided for creating tabs from regular cut-sheet stock after printing by partially punching out a section of a sheet and folding the punched out section back on itself at the remaining side. The location of the punched out section is such that when folded back, a portion of the punched out section sticks out beyond the border of the original paper size. Tab labels may be printed on the back side of the sheet so that when folded out, the tab label is in the correct orientation, i.e., facing front on the folded out tab. The punch head, which is used to punch out the section of the sheet, may be oriented flexibly and moved outboard or inboard. Tabs may be cut and folded to produce a readable set of tabs along any of the top, bottom, lead or trail edges of a sheet.
US08545373B2 Shoulder stretcher and method of use
A human shoulder stretcher and method of use for gradual, progressive posterior capsular stretching to rehabilitate the shoulder, in particular to address tightness of the posterior capsule of the glenohumeral joint through use of a lever arm and ratcheting mechanism that permits a patient to stretch his or her shoulder without the need for a therapist present.
US08545372B2 Rehabilitation exercising equipment that can extend a user's arms and legs
Rehabilitation exercising equipment includes a main frame, a first geared member rotatably mounted on the main frame, a second geared member rotatably mounted on the main frame, a connecting mechanism mounted between the first geared member and the second geared member so that the first geared member and the second geared member are movable in concert with each other, a first idle geared member rotatably mounted on the main frame and connected with the connecting mechanism, a second idle geared member rotatably mounted on the main frame and connected with the connecting mechanism, and two handlebars secured on the first geared member and the second geared member respectively. Thus, a user's hands can hold the handlebars to pivot the handlebars in two opposite directions by connection of the connecting mechanism so as to achieve an exercising or rehabilitating function.
US08545366B2 Shiftable clutch device, particularly friction wet clutch, drive train for a hybrid system and method for operating the drive train and vehicle including the drive train
A shiftable clutch device for disconnecting a first drive machine from a drive train and connecting it thereto, including a control device that can be actuated by a pressure medium, is characterized according to the invention in that the shiftable clutch device includes two partial clutches, a first partial clutch forming a main clutch and a second partial clutch forming a drag clutch, which are disposed and configured such that each is adapted to produce a drag torque in an end position of the control device, a first opening end position characterized by an open state of the main clutch and a second closing end position characterized by a closed state of the main clutch.
US08545363B2 Switchable planetary gear set in a handheld machine tool
A switchable planetary gearbox in a hand-held power tool includes multiple planet carriers having associated planet wheels, and is to be displaced between at least two gear ratios, such that the gear ratios are to be engaged via a displaceable switching ring gear. At least three planet carriers having associated planet wheels are provided axially behind one another, such that in a position fixed with respect to the housing, the switching ring gear is rotationally coupled to the planet wheels on the second-stage planet carrier and simultaneously to the planet wheels on the third-stage planet carrier.
US08545360B2 Variable ratio transmission
A variable ratio transmission having an infinitely variable ratio, for enabling a tidal turbine (10) or the like running at relatively low but continuously varying speeds, to drive smoothly a constant speed machine, such as a synchronous generator or the like, without excessive transient torques. A preferred transmission includes a primary differential gear train (120), having a driven input (50), and a driving output, wherein the ratio of the input speed to output speed is variable, and wherein said ratio is governed by the reaction torque provided by speed controlling gearing (150) within the primary differential (120), the transmission including a secondary differential gear train (220), which is in rotational communication with the input (50) via a first route (115), and is in rotational communication with the speed controlling gearing (150) via a second different route (125), wherein the secondary differential gear train includes two parallel power paths.
US08545354B2 Method and apparatus for hydraulically deactivating a torque transfer clutch
A torque transfer apparatus for a transmission includes a rotatable friction clutch pack including a first friction plate that is contiguous to a second friction plate, with the first friction plate coupled to a first transmission element and the second friction plate coupled to a second transmission element. A Belleville spring device is configured to urge the first friction plate to engage the second friction plate to effect torque transfer therebetween when a hydraulically-activated piston is deactivated. The hydraulically-activated piston is configured to urge the second periphery of the Belleville spring device away from mechanical contact of the first friction plate when the hydraulically-activated piston is activated.
US08545353B2 Drive configurations for high hybrid series/parallel high speed motor drive systems
A motor drive system configuration for a vehicle. The motor drive system includes an engine operable for providing power to the vehicle, a motor operable for providing power to a first wheel and a second wheel of the vehicle. The motor drive system also includes a first transmission mounted between the engine and the motor and in operative engagement with the motor and the engine. The first transmission includes a first clutch for coupling and decoupling the motor with the engine. The motor drive system also includes a differential in operative engagement with the transmission and coupled to the first wheel and the second wheel, and a clutch for disabling the connection between the motor and the wheels.
US08545351B2 Belt tensioner with high damping rubber device
“BELT TENSIONER WITH HIGH DAMPING RUBBER DEVICE”, the present invention refers to the technical field of belt tensioners in general, more specifically a belt tensioner (1) with high damping and with a rubber device (2), designed to generate higher rigidity and high damping to belts in combustion engines. The object of the tensioner is to reduce manufacturing costs, wearing and noise, both of the tensioner itself and the belt.
US08545346B2 Multi-piece solid golf ball
The invention provides a multi-piece solid golf ball composed of a solid core, a cover, at least one intermediate layer interposed therebetween, and a plurality of dimples on a surface of the ball. The diameter of the solid core, the deflection of the core when compressed under a final load of 130 kgf from an initial load of 10 kgf, the hardness at the center of the core, the hardness in a region 5 mm to a region 10 mm from the center of the core, the hardness in a region 15 mm from the center of the core, and the surface hardness are set within specific ranges. The intermediate layer is composed primarily of a material obtained by mixing under applied heat a specific resin composition.
US08545343B2 Golf club head or other ball striking device with slotted face mask
A ball striking device, such as a golf club head, includes a head that includes a face having an outer surface located at a front of the head, a body connected to the face and extending rearward from the face, and a face mask connected to the outer surface of the face, the face mask having a first surface configured for forming at least a portion of a ball striking surface of the head configured for striking a ball, a second surface opposite the first surface and confronting the outer surface of the face, and a plurality of elongated slots extending completely through the face mask, from the first surface to the second surface. The slots combine with the outer surface of the face to form a plurality of face grooves on the ball striking surface.
US08545335B2 Toy with memory and USB ports
A system and method for a toy with memory (flash memory) storage capabilities and a method for the toy to connect to other like toys and to a computer and he internet for online virtual play and simulation. Connection to a computer system allows the user the ability connect to the internet and register the toy allowing the user access to interact with a virtual activities and scenarios including a virtual computer image and animation of the toy connected to a computer which is connected to the Internet. User may also purchase or win a USB (Universal Serial Bus) node or dongle with codes that attach to the USB connection on the toy to allow access to special rooms and events in the virtual world on the website. The status of the game is saved back to the memory storage in the toy.
US08545334B2 Method of linking devices to gaming machines
Gaming software interfaces to hardware through high level drivers loaded in resource repositories. The high level drivers can be software or hardware drivers. Software drivers can simulate hardware, connect to other parts of the gaming software, or combine functions by calling other software and hardware drives. New drivers can be added easily, allowing gaming software to use new hardware with little or no changes.
US08545330B2 Contextual in-game messaging system
A method of enabling in-game contextual chatting is disclosed. A request for information about an online game currently being played by a first player and a second player is received. A previous online game that was previously played by the first player and the second player is determined. A chat transcript is generated that pertains to the online game in response to the request for the information, the chat transcript spanning from the online game currently being played by the first player and the second player to the previous online game that was previously played by the first player and the second player.
US08545329B2 Gaming machine which determines whether common game start condition is met for each gaming terminal, and gaming method thereof
A gaming machine: determines, for each slot machine 10, whether a common game start condition is met, based on an accumulated value relative to bet amount information transmitted from each slot machine 10 for each unit base game; and when the common game start condition is met at any one of the slot machines 10, executes a common game at each of the slot machines 10.
US08545328B2 Portable electronic charge device for card devices
Various card devices and methods involving card devices are described. Other embodiments are also described.
US08545327B2 Amusement device including means for processing electronic data in play of a game in which an outcome is dependant upon card values
Various card devices and methods involving card devices are described. Other embodiments are also described.
US08545325B2 Communication game system
A communication game system includes a plurality of game apparatuses which can be communicated via a network and functions as a parent machine and as a child machine, for example. In the child machine, a moving track of an object to be operated is obtained in response to an input with a pointing device by a player, and transmitted to the parent machine. In the parent machine, a movement of the object is controlled by the moving track, and drawing information to draw a virtual game space including the moved object is transmitted to the child machine. In the child machine, a game screen including the object to be operated is generated and displayed on the basis of the received drawing information.
US08545316B2 Gaming system and method for providing a progressive award multiple times before resetting the displayed value of the provided progressive award
In various embodiments, the gaming system and method disclosed herein maintains a progressive award that is associated with a plurality of different progressive award trigger values or progressive award hit values. In such embodiments, the displayed value of the progressive award does not reset to a reset value or reset amount until the displayed value of that progressive award has incremented to each of the plurality of progressive award hit values associated with that progressive award. In these embodiments, the gaming system provides a plurality of displayed incremented values of a progressive award a plurality of times before the displayed value of that progressive award is reset to the reset value. Such a configuration provides that after the gaming system provides a currently displayed value of a progressive award to a player at least a first time, the displayed value of that progressive award continues incrementing from the provided value.
US08545312B2 Gaming system, gaming device, and method changing awards available to be won in pending plays of a game based on a quantity of concurrently pending plays of the game
Gaming systems, devices, and methods configured to change winnable awards of a pending play of a game based on a quantity of concurrently pending plays of the game are provided. The gaming system enables a player to sequentially initiate multiple plays of a game such that a plurality of plays are concurrently pending. Each play of the game includes one or more awards available to be won in that play. When a quantity of concurrently pending plays of the game is greater than or equal to a designated quantity of plays of the game, the gaming system changes one or more of the awards available to be won in one or more of those concurrently pending plays of the game, and they remain changed as long as the quantity of concurrently pending plays of the game is greater than or equal to the designated quantity of plays of the game.
US08545308B2 Gaming system and method for providing and redeeming partial wagering game outcomes
Methods, computer readable media and systems related to wagering games, and in particular those that concern providing and redeeming partial game outcomes. One example method includes receiving a completion request from a player who is operating a gaming device to complete at least one partial game outcome. The partial game outcome was previously provided to the player, who used a first device that is different than the gaming device. This example method includes determining that the player is entitled to a complete game outcome, displaying the partial game outcome on the gaming device, determining the complete game outcome, and then displaying the complete game outcome.
US08545307B2 Gaming system, gaming device, and method providing a game with multi-component symbols and awards based on common components
The gaming system receives a wager from a player for a play of a game including a plurality of multi-component symbols. Each of the multi-component symbols includes a plurality of symbol component locations. A plurality of the multi-component symbols include at least one of the symbol components in at least one of the symbol component locations. The gaming system randomly generates and displays a plurality of the multi-component symbols. The gaming system determines, for a first one of a designated number of the displayed multi-component symbols, a quantity of symbol component locations of the first one of the displayed multi-component symbols that display one of the symbol components and that correspond to a symbol component location of each of the other displayed multi-component symbols of the designated number of the displayed multi-component symbols that each display one of the symbol components. Any awards are determined based on the determined quantity.
US08545305B2 Devices, systems, and methods for dynamically simulating a component of a wagering game
Gaming devices, gaming systems, methods of conducting a wagering game, and computer programs for initiating a wagering game are presented herein. A gaming device is presented that includes a wager input device for receiving wagers from players to play a wagering game, and a display for displaying outcomes of the wagering game. The gaming device also includes a multi-layer composite lighting assembly with a first light-emitting layer, a second light-emitting layer, and a spacer. The first light-emitting layer emits light of a first color in a first direction, whereas the second light-emitting layer emits light of a second color in a second direction. The spacer, which is interposed between the first and second light-emitting layers, diffuses and focuses light emitted by the second light-emitting layer through the light emitted by the first light-emitting layer to thereby create a three-dimensional simulation of a component of the wagering game.
US08545304B2 Wagering game with bonus game triggered by linked terminal
The present invention is directed to a gaming terminal and a method of playing a wagering game, whereby a player at one gaming terminal is allowed to link to other gaming terminals via a player-selectable option. The wagering game may include a basic game and a bonus game. Once linked, the player can enter a bonus game that is triggered by an outcome at a linked terminal.
US08545302B2 Electronic paper game systems and related methods for updating game interface, and computer program product thereof
Electronic paper (E-paper) game systems are provided. The E-paper game system at least includes a chessboard and a plurality of chessmen. The chessboard at least includes a first E-paper display unit for displaying a graphical data of a first chessboard for a first game interface. Each of the chessmen includes a second E-paper display unit for displaying a graphical data of a first chessman which corresponds to the graphical data of the first chessboard. The chessboard and the chessmen respectively update the graphical data of the first chessboard displayed by the first E-paper display unit and the graphical data of the first chessman displayed by the second E-paper display unit to a graphical data of a second chessboard corresponding to a second game interface and a graphical data of a second chessman which corresponds to the graphical data of the second chessboard.
US08545294B1 Field dressing apparatus and system
A field dressing apparatus and system preferably includes a plurality of ground stabilizing components, a plurality of a tethering members and a plurality of engaging components. Each ground stabilizing component includes a shaft element that extends from a handle element. A proximal end of the tethering member is secured to the ground stabilizing component and a distal end is secured to the engaging component. The engaging component preferably includes a hook section, a gripping section and a ring section. The hook section extends from one end of the gripping section and the ring section is disposed on the other end of the gripping section. The distal end of the tethering member is secured to the ring section of the engaging component. A second embodiment of the dressing apparatus and system includes the plurality of a tethering members, a plurality of engaging components and a compacting securing panel.
US08545293B2 Stick feeding unit in a suspension device for sausage-type packaging units
The invention relates to a smoking stick feeding unit (10) which comprises lifting device (12) that allow a plurality of smoking sticks (15) to be lifted simultaneously. In the top position of lift, the top smoking stick is transferred to a transport means for a horizontal movement into the loading position. The smoking stick feeding unit can be used to feed smoking sticks for loading with very long packaging units or sausages in a suspension device.
US08545277B2 Terminal block
A terminal block includes a first end, a second end, a top surface and a bottom surface. A first connection socket is disposed on the top surface in proximity to the first end of the terminal block. A second connection socket is disposed on the top surface in proximity to the second end of the terminal block. A thermocouple connector is disposed on the top surface and is coupled to the first connection socket and the second connection socket. In one embodiment, the thermocouple connector is a miniature type SMP thermocouple connector. In one embodiment, a system of interconnected components employs the terminal blocks at a plurality of control points. A meter is selectively coupled to the terminal blocks for measuring, sensing and collecting at least one of data and information at the plurality of control points.
US08545275B2 Electrical connector with touch-safety contact structures
An electrical connector with touch safety contact structure. The connector includes an insulative housing, a contact and at least one protecting insulator. The insulative housing defines a mating direction, a mating face and a receiving cavity recessed from the mating face along the mating direction. The contact is received in the insulative housing and includes a contacting portion exposed into the receiving cavity, a retaining portion extending from one end of the contacting portion to be interferentially received in the insulative housing, and a forward end extending from the other end of the contacting portion to locate more closely to the mating face of the insulative housing than the contacting portion, and a connecting portion extending from the retaining portion to be exposed beyond the insulative housing. The protecting insulator covers the forward end of the contact. An additional grounding contact assembled to the insulative housing may be included.
US08545273B1 Electrical connector
An electrical connector includes an electrically insulative holder member, a signal module formed of a circuit board with longitudinal terminal holes, circuit lines, electrical contacts and via-holes, metal contact terminals and metal mounting terminals, and a metal shield. The metal contact terminals have rear soldering end portions thereof respectively soldered to respective circuit lines, front contact portions thereof positioned in front ends of the longitudinal terminal holes of the circuit board and middle suspension arms thereof connected between the rear soldering end portions and the front contact portions and suspending below the longitudinal terminal holes. The electrical contacts of the circuit board are positioned in respective bottom contact holes of the tongue plate. The circuit lines electrically connect the electrical contacts and the metal contact terminals to the via-holes. The surface area of each circuit line may be modified to adjust impedance, reducing interference.
US08545268B2 Electrical connector assembly
An electrical connector assembly includes a shielding cage member having an upper port and a lower port. A separator member extends between side walls of the cage member between the upper and lower ports. The separator member has a channel between upper and lower plates. The upper plate has an upper inner pocket facing the channel and an upper outer pocket facing the upper port. The lower plate has a lower inner pocket facing the channel and a lower outer pocket facing the lower port. An upper inner RF absorber is positioned within the upper inner pocket. An upper outer RF absorber is positioned within the upper outer pocket. A lower inner RF absorber is positioned within the lower inner pocket. A lower outer RF absorber is positioned within the lower outer pocket.
US08545267B2 Electrical connector assembly
An electrical connector assembly includes a shielding cage member having an upper port and a lower port configured to receive pluggable modules therein with side walls along the sides of the upper and lower ports. A separator member extends between the side walls between the upper and lower ports. The separator member has an upper plate and a lower plate with a channel therebetween. The upper and lower plates have interior surface facing the channel and exterior surfaces facing the upper and lower ports, respectively. RF absorbers are positioned along the exterior surfaces and are exposed along the upper and lower ports. The RF absorbers reduce an amount of EMI propagation through the cage member. A divider wall is positioned in the channel and extends between the interior surfaces of the upper and lower plates.
US08545265B2 Device connector and method of manufacture
A terminal block in which a plurality of metal conductive plates (10) to be connected to device-side busbars provided in a motor are made integral by a connector housing (50) includes a primary molded article (60) in which the plurality of conductive plates (10) are made integral by a connector housing (50); a metal plate (30) to be attached and fixed to a motor case; and a secondary molded portion (70) integrally forming the primary molded article (60) and the metal plate (30). The secondary molded portion (70) is formed by a secondary molding die including both upper and lower dies (90, 91) and a slide die (92). Pairs of tight holding portions (69, 69) for tightly holding the slide die (92) are provided on the primary molded portion (61) before the secondary molded portion (70) is formed.
US08545263B2 Clamp and grip coaxial connector
A coaxial connector with a connector body is provided with a connector body bore. An annular coupling groove is provided in the connector body bore open to a cable end of the connector body. A clamp sidewall of the coupling grove is angled inward from a bottom of the coupling groove. A slip ring seated within the coupling body bore is provided with a grip surface. An annular compression body is positioned between the slip ring and the clamp sidewall. The connector body and the coupling body are coupled together via threads. The slip ring is dimensioned for axial advance of the coupling body along the threads to exert a compression force against the compression body to clamp a leading edge of the outer conductor between the compression body and the clamp sidewall.
US08545262B2 Shorting clip for an airbag ignition system
Shorting clip for an ignition system adapted to be mounted in a retainer insert, including two contact members adapted to each contact a pin of a squib to short-circuit the pins and a first grounding contact adapted to contact a ground contact of a squib connector and at least one second grounding contact adapted to contact an electroconductive part of a squib. The clip further includes a support structure connecting the contact members and the first and second grounding contact with each other, which support structure is adapted to be arranged essentially parallel to the plug-in direction of the retainer insert.
US08545256B2 Electrical connector for use with NATO equipment
To attach a cable to a NATO slave receptacle, a wire from the cable may be passed through an opening in a cable receiving member and connected to a tab formed on a NATO plug. The cable receiving member may then be attached to the NATO plug. The NATO plug may then be engaged to a NATO slave receptacle to create an electrical connection between the NATO slave receptacle and the cable. If desired, the NATO plug and receiving member can be easily detached from the cable and used with another cable.
US08545255B2 Subcutaneous device for electrical percutaneous connection
The invention concerns an electrical connection system for a percutaneous electrical connection between an electrical device (2) inside an animal body and an electrical device (3) outside said body, comprising a subcutaneous device (10) designed to be connected to internal electrical device (2), said subcutaneous device (10) comprising: an open housing (11) having at least one inner compartment (12), said compartment (12) being filled with a conductive material into which an electrical connection plug can be inserted, the conductive material of compartment (12) being further connected to connection means (5) designed to be connected to internal electrical device (2); a sealing membrane (13) for sealing housing (11), said sealing membrane (13) being formed of an insulating and flexible material designed for insertion of electrical connection plugs from outside housing (11) through said sealing membrane (13) to the conductive material of compartment (12); characterized in that housing (11) comprises alignment means (14) to facilitate positioning and to guide the insertion of electrical connection plugs into the corresponding conductive materials.
US08545254B2 Releasably engaging high definition multimedia interface plug
A releasably engaging high definition multimedia plug comprises a plug body and an actuator operable with the plug body to move a locking tab of the plug and facilitate releasable engagement of the plug with a standard high definition multimedia receptacle. A corresponding method of releasably securing a high definition multimedia interface plug into standard high definition multimedia interface receptacle is also provided.
US08545253B2 Releasably engaging high definition multimedia interface plug
A high definition multimedia interface connector comprising a connector body having an extension configured to be inserted into a high definition multimedia interface receptacle, and at least one projection on an outer surface of the extension to facilitate releasable engagement of the plug with a standard high definition multimedia receptacle. A corresponding method of releasably securing a high definition multimedia interface plug to a standard high definition multimedia interface receptacle is also provided.
US08545247B2 Dock for a portable electronic device
A dock for receiving a portable electronic device, including a housing comprising an aperture; a support coupled to an inner wall of the housing, a portion of the support being elastically deformable; and a connector received in the support and extending through the aperture for electrically communicating with the portable electronic device, wiring of the connector for transferring data to an electronic device; wherein the portion of the support elastically deforms in response to non-axial movement of at least a portion of the connector.
US08545246B2 High connectivity platform
An apparatus, in accordance with particular embodiments, includes a shell comprising two substantially parallel surfaces. The apparatus further includes a plurality of connector housings mounted between the two substantially parallel surfaces. The apparatus also includes a plurality of connectors coupled to the plurality of connector housings. Each connector is configured to move along at least one axis within its respective connector housing. The apparatus further includes a plurality of cables. Each cable is configured to couple together at least two connectors. The plurality of cables are arranged between the two substantially parallel surfaces.
US08545237B2 Connector for interconnecting conductors of circuit boards
A connector comprises a generally cylindrical dielectric body with a central bore in the dielectric body. The dielectric body has a first end and second end opposite the first end. Conductors extend axially through the cylindrical dielectric body and are spaced apart from each other in a generally circular or elliptical arrangement. Each conductor comprises an embedded portion in the dielectric body and mating portions extending from the first end and the second end.
US08545234B2 Electrical connector for a pluggable transceiver module
A pluggable module includes a housing having a locating opening that is at least partially defined by a wall of the housing. A circuit board is at least partially disposed within the housing and includes an edge and a mating contact. An electrical connector is mounted to the circuit board and includes an electrical contact having a mounting segment that is configured to be electrically connected to the mating contact of the circuit board. The electrical connector includes a dielectric connector body that holds the electrical contact. The body has a base that is coupled to the edge of the circuit board and a locating boss that extends outwardly on the base. The locating boss is received within the locating opening of the housing and includes a crush rib that extends outwardly from the locating boss. The crush rib is deformed and engaged with the wall of the housing.
US08545233B2 Laptop-based machine control simulator
A machine tool control simulator for a machine tool control having a plurality of first user-actuatable devices and a first display screen is disclosed. The machine tool control simulator may include a console and a laptop computer. The console may include a plurality of second user-actuatable devices each corresponding to a respective one of the first user-actuatable devices, and having a layout substantially similar to a layout of the first user-actuatable devices. The laptop computer includes a keyboard and an attached second display screen. The keyboard may be placed between a tabletop and the second user-actuatable devices. The computer receives user inputs from the second user actuatable devices and displays images on the second display screen to simulate images that would be displayed on the first display screen of the machine tool control in response to the user inputs.
US08545232B1 Computer-based student testing with dynamic problem assignment
The system automatically personalizes the assignment of problems to students in learning situations to enable every student to learn as efficiently and effectively as possible. Students are continuously tracked on their individual learning curve so that both they and their teachers can immediately see their progress and growth, and assess their need for additional support or instruction. Further, the system can immediately grade each exercise and provide instant feedback to both students and teachers without burdening the teacher with the grading of homework. Still further, the system incorporates a teacher settable mastery level control and a student learning efficiency meter that returns the “locus of control” over learning back to the student to enhance their concentration and motivate effective, efficient learning by enabling them to do just the number of problems that it takes to reach mastery of the topic or lesson. The system does this with problems from any source and for any discipline at every age level. It further links student assignments to other content either provided by the system or linked to the system to support instruction in the classroom, in labs, or on-line.
US08545230B2 Method and apparatus for a non-nutritive suck entrainment pulse generator
This document discusses, among other things, method and apparatus for a non-nutritive suck (NNS) entrainment pulse generator. An embodiment includes a valve assembly in communication with a first pressure and a second pressure to change a pressure of a baglet. A controller can switch the valve assembly to selectively couple the first and second pressures to the baglet to produce a series of pressure pulses within the baglet. In an embodiment, the pulse generator is substantially self-contained. In an embodiment, the valve assembly includes a reciprocating piston assembly to generate the series of pressure pulses. In an embodiment, the NNS entrainment pulse generator is portable.
US08545226B2 Firearm shooting simulator
A firearm shooting simulator includes an image capturing device fitted to a firearm and configured to capture at least one image of a target, once activated. The system further includes a processor which is configured to determine any variance between a center point of the image captured and a point on the target sighted by the firearm when the image is captured. This is achieved by sighting the firearm at a particular point on the target and programming the processor with the location of this sighted point. Once the processor is aware of which point is sighted by the firearm, the image is captured and the processor determines a center point of the image captured.
US08545225B2 Redox-curing type composition
The present invention provides a redox-curing type composition that penetrates into a wet body, particularly into a tooth structure (dentin), is cured in an accelerated manner by the moisture contained in the wet body, thereby exhibits a higher bond strength than those of conventional redox-curing type compositions, and has satisfactory storage stability. The present invention is a redox-curing type composition including a polymerizable monomer (a) having an acidic group, a polymerizable monomer (b) having no acidic group, a powdery inorganic peroxide (c) with an average particle diameter of 0.01 to 50 μm, an amine-based reducing agent (d), and a polymerization accelerator (e). The amine-based reducing agent (d) includes an aromatic amine (d−1) and an aliphatic amine (d−2), and a weight ratio (d−1):(d−2) therebetween is 5:1 to 1:50.
US08545224B2 Method for improving productivity and personalization for dental prostheses
A method for increasing the speed in setting artificial teeth in full dentures or dental prostheses. The method provides premade tooth segments, the premade tooth segments including at least one tooth that may be preset into a gingival roll manufactured with either the individual teeth connected together in the gingival roll or by a mid-tooth connection at the mesial and distal surfaces of each tooth in the segment. The method further includes setting the premade tooth segments into a wax bite rim and fitting the wax bite rim to the patient's mandibular or maxillary arch. Another aspect is a method for individualizing the denture or dental prosthesis whereby the incisors can be manipulated to create a personal and natural appearance.
US08545221B2 Smile designer
Various methods and systems for designing a restored smile are provided. One method includes receiving scan data of a patient's teeth, developing a digital model of the patient's teeth via a computing device, where the model represents the patient's teeth based upon the scan data, creating a dental treatment plan to restore one or more teeth from an initial condition to a successive condition, and wherein a final condition of the one or more is based on the one or more teeth having at least one planned additional restorative tooth structure provided therewith.
US08545220B2 Orthodontic treatment tube
Provided is an orthodontic treatment including a main tube, and a pair of caps provided at both ends of the main tube to form an adhesion space therebetween in which an adhesive is accommodated and the adhesive is prevented from flowing into the main tube through an insertion hole of the main tube.Since the adhesive is applied to the adhesion space formed by fitting the pair of caps onto the outer circumference of the main tube, the caps can prevent the applied adhesive flowing into the main tube and the wire can be easily inserted into the main tube.
US08545212B2 Mold-tool system having melt splitting device including uninterrupted melt channels extending from inlet and outlets
A mold-tool system is provided which includes a melt distribution device and a melt splitting device configured to interact with the melt distribution device. The melt splitting device includes a single inlet and multiple outlets spaced from the single inlet. The outlets are configured for fluid communication with the melt distribution device. The melt splitting device further includes a plurality of uninterrupted melt channels, where each melt channel extends from the inlet to an associated one of the outlets.
US08545211B2 Method for manufacturing and attachment of wing fairings
A method and apparatus for manufacturing and installing a fairing on an aircraft. In one advantageous embodiment, a composite fairing is installed on the aircraft. A composite sheet having a form of the composite fairing is formed. A plurality of cured composite tiles is created from the composite sheet, wherein spaces are present between the plurality of composite tiles. The plurality of composite tiles is cured to form the composite fairing. The composite fairing is attached to a surface of the aircraft. The spaces between the plurality of composite tiles are filled with a flexible filler.
US08545209B2 Three-dimensional object forming apparatus and method for forming three-dimensional object
A three-dimensional object forming apparatus is provided, which at least comprises: a construction stage, a printing module, plural temporary storage tanks, plural powder supplying tanks, a construction tank, a printing quality inspection component for forming a pattern to determine whether the printing module is blocked or not, a maintenance device, and a dust-proof device.
US08545204B2 Mold having movable plate-shaped cores
A mold for fabricating an optical fiber connector is disclosed. The optical fiber connector includes a blind hole for accommodating an optical fiber and an aspherical lens portion for optically coaxial with the optical fiber. The mold includes a rod-shaped core for forming the blind hole and a plate-shaped core. The plate-shaped core includes an aspherical recess for forming the lens portion. The aspherical recess faces the rod-shaped core, and is adjustably movable relative to the first core so as to achieve alignment between the aspherical recess and the rod-shaped core.
US08545202B2 Mould system for manufacturing a container
A mould system for manufacturing a container which includes a movable mould half and a stationary mould half which are positioned opposite to each other, wherein the movable mould half includes a core plate provided with a core, a plate-like seal ring that is movable relative to the core, a seal surface which surrounds the core, and a collar ring that is movable relative to the core and the stationary mould half includes a mould plate provided with a mould cavity and a seal surface, wherein in the mould system, a plate-like insert is connected to the seal surface of the seal ring, the insert including a recess which is in contact with a front edge of the seal surface, so that it is in flow communication with molten plastic material flowing from the direction of the collar ring.
US08545201B2 Curing system using electromagnetic force
A system for forming a composite structure comprises an electromagnetic press including an upper die, a lower die and an electromagnet. The lower die may be mounted in spaced relation to the upper die for receiving a composite layup therebetween. The electromagnet is energizable such that the upper and lower dies apply a compressive force to the composite layup.
US08545200B2 Variable displacement oil pump
Variable displacement oil pump includes a: rotor; vanes; cam ring; housing; biasing member biasing the cam ring in a direction enlarging an eccentricity between centers of the rotor and inner circumferential surface of the cam ring; a contact surface to contact with a cam ring outer circumferential surface via a biasing force applied to the cam ring by the biasing member; a control chamber separately formed by the contact surface and a swing fulcrum of the cam ring on a cam ring outer circumference when the contact surface contacts the cam ring outer circumferential surface, and causing the cam ring to swing against the biasing force of the biasing member by a pressure from a discharge portion to the control chamber; and a choking portion formed on the outer circumferential surface of the cam ring to maintain a pressure of the control chamber even when the cam ring swings.
US08545199B2 Regulatable vane-cell pump with a sealing web curving in an arc
The invention relates to a vane pump (1), in particular a regulatable oil pump for a lubricating system, with a pump housing (2) with at least one housing tank (6) and with a vane rotor (11) disposed in the housing tank (6) mounted so that it can be rotated by means of a drive shaft (10) in the pump housing (2) constituting an axis of rotation (23) which provides a mount for vanes (15) in approximately radially extending fitting slots (14). An adjusting ring (27) is provided enclosing the vane rotor (11) and circumferentially bounding pump cells (26) which, by means of a cylindrical internal wall surface (31), can be displaced between a concentric position with respect to the vane rotor (11) and an eccentric position relative thereto, to which pressured is applied by positioning torques caused by the medium pressure and a positioning mechanism (47) in order to regulate a pressure level.
US08545197B2 Pump, especially for blood treatment
The invention relates to a pump, especially usable as a peristaltic pump in an apparatus for blood treatment, wherein it is provided with at least a hammer element which interacts with at least one tube portion in which a fluid to be pumped flows and with motion means for said hammer element which push the hammer element against said tube portion so as to press it, the value of the stroke executed by said element not allowing the complete crushing of the tube itself.
US08545196B2 Hose pump
A hose pump for delivering fluids includes a housing having a base body and a cover. A pump body for delivering a fluid is rotatably disposed in the interior of the base body about an axis. A locking device is disposed on the housing in order to release and lock the cover. The pump body comprises a plurality of rollers disposed at the circumference of the pump body and delivering a fluid present in a hose by rotating the pump body. The rollers clamp the hose against an inner surface of the cover, and the locking device is attached captively to the base body and displaceably relative to the base body, and can be actuated single-handedly. The cover is attached captively to the base body and displaceably relative to the base body of the housing, and can be actuated single-handedly.
US08545189B2 Method and arrangement for controlling a pumping station
A method and an arrangement for controlling a pump station includes measurement of the surface level of a liquid (465) by means of a sensor (452) and controlling the electric drive (401, 420, 430) of the pump (440) to a predetermined speed of rotation when a specific surface level value has been reached. This predetermined rotation speed value is preferably the rotation speed at which the ratio of the flow rate to the consumed power, i.e. the efficiency, is optimal. The measurement of the surface level and the related data processing for control of the pump are performed in a frequency converter (420) in conjunction with the control.
US08545188B2 Controller and the use thereof
A hydraulic controller having at least one input for a hydraulic fluid for controlling the speed of a hydraulic pump driven by an internal combustion engine is characterized in that the controller has at least two inputs, that at least two pressure chambers each connected to one of the inputs are provided, that each of the same has a piston displaceable under pressure from a rest position against the force of a spring into a switched position and that the piston rod thereof engages at the end of a rod or a pull in the switched position.
US08545185B2 Turbine engine components with environmental protection for interior passages
Turbine airfoil components with protective layers and methods therefore. The components are each formed to have a platform, an airfoil extending upwardly from the platform, and a shank extending downwardly from the platform. The shank has an exterior wall and an internal passage, and the airfoil has a cooling flow channel inside the airfoil for flowing a cooling flow therethrough. The component has an interior chromide coating contacting at least a portion of an interior surface of the shank and interdiffused with a base metal thereof, and an exterior chromide coating contacting at least a portion of an exterior surface of the shank and interdiffused with the base metal thereof. The interior and exterior chromide coatings do not have an aluminide coating deposited thereon.
US08545184B2 Locking spacer assembly
The present application describes a locking spacer assembly for use with a groove in a rotating disk. The locking spacer assembly may include a locking spacer with a leg and a wedge tool in contact with the leg so as to pull the leg inward and into the groove.
US08545177B2 Radial compressor with a diffuser for use in a turbocharger
A radial compressor, in particular for a turbo-charger, has a spiral housing and a diffuser. The diffuser is constructed such that a low-pressure region in the area of the transition between the spiral housing and the tongue is at least reduced.