Document Document Title
US10982262B2 Quencher and use thereof
The present invention relates to a quencher having a quenching effect on a fluorescent material exhibiting luminescence characteristics at an excited energy level, and various uses thereof.
US10982259B2 Long non-coding RNA gene expression signatures in disease monitoring and treatment
Differential expression of long non-coding RNAs (lncRNAs) and enhancer RNAs (eRNAs) are used to monitor diseases and determine therapeutic efficacy in, for example, neurological diseases, inflammatory diseases, rheumatic diseases, and autoimmune diseases. Machine learning systems are used to identify lncRNAs or eRNAs having differential expression correlated with responsiveness to various therapies.
US10982257B2 Methods to profile molecular complexes or single cells via proximity dependent barcoding
Method for studying constituents of individual molecular complexes by labelling the molecules belonging to the same complex with at least one set of molecular constructs, wherein each set member includes a Unique Identifying Sequence (UIS), which is a nucleic acid sequence unique for each set member, and at least one Common Tag Sequence (CTS), which is a nucleic acid sequence common to all set members, by: attaching the molecular construct to the complex by ligating or hybridizing the molecular construct to a nucleic acid molecule of the complex, or ligating or hybridizing the tag to a nucleic acid linked to an affinity binder that binds specifically to a constituent of the complex; labelling the molecules belonging to the same complex using the molecular construct tags as primers or templates in a nucleic acid polymerization reaction; and analyzing the composition of the complex by analyzing combinations of UISs and CTSs.
US10982252B2 Bacterial systems for analyzing ubiquitylated polypeptides
Bacterial systems for analyzing ubiquitination of proteins is disclosed herein. Kits for analyzing the ubiquitination and methods for carrying out the analysis are also disclosed.
US10982251B2 Method of making an electrochemical sensor strip
A method of making an electrochemical sensor strip that includes: depositing a first electrode on a base; depositing a second electrode on the base; applying a first layer onto the first electrode; and applying a second layer onto the second electrode. The first layer includes an oxidoreductase and a mediator. The second layer includes a soluble redox species.
US10982249B2 Production of steviol glycosides in recombinant hosts
The invention relates to recombinant microorganisms and methods for producing steviol glycosides and steviol glycoside precursors.
US10982247B2 DNA polymerase mutants having enhanced template discrimination activity
This invention relates to mutant DNA polymerases having an enhanced template discrimination activity compared with the corresponding unmodified DNA polymerase counterparts, wherein the amino acid sequence of the mutant DNA polymerase includes at least one substitution at residue positions structurally and functionally homologous or orthologous positions 783 or 784 of an unmodified Taq DNA polymerase.
US10982242B2 Coordinated-control coenzyme Q10 fermentation production process based on online oxygen consumption rate and electrical conductivity
The present invention relates to an optimized fermentation process of coenzyme Q10, particularly to a fermentation process of coenzyme Q10 via flow feeding based on cooperative control of changes of online oxygen consumption rate and conductivity. During the fermentation process of coenzyme Q10 production strains, the oxygen consumption rate is controlled between 30-150 mmol/L·h and the conductivity is maintained between 3.0-30.0 ms/cm via flow feeding, so as to facilitate strain growth and the start of coenzyme Q10 synthesis and accumulation. The present invention can substantially increase output of coenzyme Q10 and greatly reduce the production cost with simple process control and strong operability, thus being applicable to large-scale industrial production.
US10982236B2 Recombinant yeast for producing 2,3-butanediol including pyruvate decarboxylase derived from candida tropicolis and method for producing 2,3-butanediol using the same
Provided is a recombinant Saccharomyces cerevisiae for producing 2,3-butanediol, wherein all GPD1 and GPD2 genes involved in glycerol biosynthesis are removed and a gene encoding NADH oxidase is introduced, and wherein pyruvate decarboxylase activity is inactivated and Candida tropicalis PDC1 gene encoding Candida tropicalis pyruvate decarboxylase 1-is introduced, and wherein expression of the Candida tropicalis PDC1 gene is regulated by a GPD2 promoter.
US10982231B2 Methods and compositions for RNA-directed target DNA modification and for RNA-directed modulation of transcription
The present disclosure provides a DNA-targeting RNA that comprises a targeting sequence and, together with a modifying polypeptide, provides for site-specific modification of a target DNA and/or a polypeptide associated with the target DNA. The present disclosure further provides site-specific modifying polypeptides. The present disclosure further provides methods of site-specific modification of a target DNA and/or a polypeptide associated with the target DNA The present disclosure provides methods of modulating transcription of a target nucleic acid in a target cell, generally involving contacting the target nucleic acid with an enzymatically inactive Cas9 polypeptide and a DNA-targeting RNA. Kits and compositions for carrying out the methods are also provided. The present disclosure provides genetically modified cells that produce Cas9; and Cas9 transgenic non-human multicellular organisms.
US10982228B2 AAV vectors for retinal and CNS gene therapy
Provided herein are improved rAAV (e.g., rAAV2, rAAVrh8R, etc.) for enhanced gene therapy of ocular disorders or CNS disorders wherein the rAAV comprise one or more substitutions of amino acids that interact with heparan sulfate proteoglycan. The invention provides methods for improved transduction of retinal cells and methods for treating ocular diseases with improved compositions of rAAV particles. Further provided herein are improved recombinant adeno-associated virus (rAAV) (e.g., rAAV2, rAAVrh8R, etc.) for enhanced gene therapy of disorders of the CNS. The invention provides methods for delivering the rAAV to the CNS, methods for treating disorders of the CNS with improved compositions of rAAV particles, and kits for delivering the rAAV to the CNS and/or treating a CNS disorder.
US10982225B2 Flowering time-regulating genes and related constructs and applications thereof
Isolated polynucleotides and polypeptides, and recombinant DNA constructs useful for regulating plant heading date or flowering time are provided. Compositions (such as plants or seeds) comprising these recombinant DNA constructs, and methods utilizing these recombinant DNA constructs are also provided. The recombinant DNA constructs comprise a polynucleotide operably linked to a promoter that is functional in a plant, wherein said polynucleotides encode flowering time-regulating polypeptides.
US10982220B2 Brassica oleracea plants with improved nutritional value
The invention provides compositions and methods relating to the elevation of glucoraphanin compared to standard Brassica oleracea varieties. The invention also relates to the production of hybrid varieties having desired glucosinolate contents. The invention further provides plants, plant parts, and seeds comprising such traits and comprising a Myb28 allele from Brassica villosa that is not genetically linked to an ELONG allele from Brassica villosa.
US10982219B2 Guayule with increased rubber production and yield
Altered guayule that produce more rubber than the amount of rubber produced by non-altered guayule are provided. The alterations may include (i) a reduction in amount of functional PaAos produced by the altered guayule, (ii) an increase in amount of a transcription factor produced by the altered guayule, (iii) an increase in amount of salicylic acid within the altered guayule, (iv) exposure of the altered guayule to cold temperature, and (v) a combination thereof. Methods of producing the altered guayule and methods of increasing the amount of rubber produced by a guayule are also provided.
US10982217B2 High-throughput cargo delivery into live cells using photothermal platforms
Methods, devices, and systems are provided for the delivery of agents (e.g., nucleic acids, proteins, organic molecules, organelles, antibodies or other ligands, 5 etc.) into live cells and/or the extraction of the same from said cells. In various embodiments the photothermal platforms and systems incorporating such photothermal platforms are provided that permit efficient, high-throughput cargo delivery into live cells.
US10982211B2 tRNA derived small RNAs (tsRNAs) involved in cell viability
The present invention features compositions and methods relating to tRNA-derived small RNAs (tsRNAs). Provided herein are oligonucleotide compositions that are complementary to tsRNAs, in particular leuCAGtsRNA, and methods of using the oligonucleotides for the regulation of respective tsRNA. Further provided are methods of inducing apoptosis through the inhibition of leuCAGtsRNA.
US10982205B2 Beta-lactamase variants
The present invention relates to an isolated polypeptide having beta-lactamase activity and nucleic acid sequences encoding the polypeptide. The isolated polypeptide of the invention is a Verona integron-encoded metallo-β-lactamase (VIM-2) variant with improved properties such as improved protease stability, stability in intestinal medium, improved activity against one or more antibiotics, improved specific activity and/or improved production in a host cell.
US10982202B2 Recombinant factor C and method for producing the same, and method for measuring endotoxin
To provide a method for producing a horseshoe crab recombinant Factor C. The horseshoe crab recombinant Factor C is produced through expression thereof by use of mammalian cells such as CHO DG44 and HEK293 as host cells.
US10982197B2 P450-BM3 variants with improved activity
The present invention provides improved P450-BM3 variants with improved activity. In some embodiments, the P450-BM3 variants exhibit improved activity over a wide range of substrates.
US10982196B2 Immunotherapy targeting intracellular pathogens
The present invention relates to the use of immunogenic peptides comprising a T-cell epitope derived from an intracellular pathogen-associated antigen and a redox motif such as C-(X)2-[CST] or [CST]-(X)2-C in the prevention and/or treatment of infection with an intracellular pathogen and in the manufacture of medicaments therefore.
US10982194B2 Non-genetic modification of enveloped viruses
The invention concerns a modified enveloped virus wherein said virus has at least one anti-tumor, tumor-specific peptide non-genetically attached to or inserted in/through the viral envelope; a pharmaceutical composition comprising same; and a method of treating cancer using same.
US10982192B2 Method for the induction of arterial-type of hemogenic endothelium from hPSCS
This invention discloses a method for the induction of arterial-type of hemogenic endothelium.
US10982190B2 Genetically modified stem cells
Described herein are human transgenic beta cells expressing fugetactic levels of CXCL12 to a subject in need thereof. Also described herein are beta cells comprising a transgene comprising a nucleic acid sequence encoding CXCL12.
US10982189B2 Methods of improving vector transduction efficiency into T lymphocytes
Provided herein are methods for enhancing the transduction efficiency of vectors into cells, e.g., primary human T lymphocytes.
US10982187B2 Bos taurus variety ‘HO840003150607238’ and methods of use thereof
The disclosure relates to Bovine germplasm of Bos taurus variety HO840M003150607238. Included in the present disclosure are cells comprising the genome of Bovine variety HO840M003150607238 characterized by the presence of homozygous loci and spermatozoa obtained from said cells. Also provided by the present disclosure are tissue cultures of cells, animals obtained from said cells, and parts thereof, including F1 spermatozoa. The disclosure further provides for methods of breeding, selecting, and using the germplasm to improve existing commercial cattle herds generated from in vitro fertilization methods and progeny cattle obtained from in vitro fertilization and implantation and artificial insemination methods.
US10982186B2 Cell culturing method and kit
The present invention relates to a cell culturing method and kit. More specifically, it relates to a cell culturing method and kit using a support that is exposed to the air. It further relates to a method of culturing cells by allowing them to migrate onto a porous polyimide film.
US10982182B2 Flow electroporation device
The present invention discloses a flow electroporation device comprising a three-dimensional electrode device and a flow electroporation chamber, the three-dimensional electrode device comprising an electrode array and an electrode fixing assembly for fixing electrodes in the electrode array, the flow electroporation chamber comprising a cavity, an inlet, an outlet and an opening, the inlet, the outlet and the opening on the cavity, and the electrode array being inserted into the cavity through the opening. By means of the above-mentioned manner, the flow electroporation device of the present invention can achieve a high throughput cell treatment, and also can work under a low voltage condition, can avoid damages to cells brought by liquid flow, can reduce effects brought by heat and cathode effect induced by electric pulses, and can maintain an closed aseptic environment.
US10982181B2 Devices for cell culture and methods of making and using the same
Devices and systems for cell culture that include one or more hollow fibers or channels integrated into a chamber are provided. The hollow fibers or channels and/or the chamber are seeded with one or more cell types. Methods of co-culturing two or more cell types in the devices are also provided.
US10982179B2 Dietary fiber
Provided is a dietary fiber characterized in that bitterness and unpleasant aftertaste are restrained. The dietary fiber has terminal sugars and is characterized in that the ratio of aldoses relative to the total of the terminal sugars is 10% or less. Such a dietary fiber may be, for example, indigestible dextrin, polydextrose or the like. The dietary fiber may be used as a food additive (for example, a beverage additive).
US10982178B2 System for wort generation
A system and method for generating wort utilizing steam injection heating and stratified flow. The system mixes a fine ground grain with water to form a slurry. The slurry is pumped through a steam injection heater to form a mash. The heated mash enters into a stratified vessel that creates a stratified temperature profile from a first end to a second end. The stratified heating vessel allows the mash to flow from the first end to the second end without internal mixing. After retention within the mash coil, the wort is directed to a mash filtration unit. After filtration, the wort enters into a boil kettle and is heated using a second steam injection heater. The boil kettle includes a spray head that directs brewing liquor onto the wort to reduce foam within the boil kettle. Finally, the wort passes through a scraped surface sieve that removes particles from the heated wort.
US10982175B2 Free standing film
A free standing film is provided including: a partially hydrolyzed polyvinyl acetate; a poly(ethylene oxide); a polyalkylene glycol; a plasticizer; optionally, a poly(isobutylene-co-maleic anhydride) copolymer; and optionally an additive. Unit dose packages including the free standing film are also provided.
US10982174B2 Synergistic surfactant blends
Synergistic surfactant blends are disclosed. In one aspect, the blend comprises an anionic surfactant and a metathesis-based cationic surfactant comprising a quaternized derivative. The quaternized derivative is a quaternized fatty amine, quaternized fatty amidoamine, imidazoline quat, or esteramine quat made from a metathesis-derived C10-C17 monounsaturated acid or its ester derivative. Also disclosed are synergistic surfactant blends comprising a cationic surfactant and a metathesis-based anionic surfactant comprising a sulfonated derivative. The sulfonated derivative is a fatty ester sulfonate, fatty acid sulfonate, sulfoestolide, fatty amide sulfonate, sulfonated fatty ester alkoxylate, imidazoline quat sulfonate, sulfonated amidoamine oxide, or sulfonated amidoamine betaine. The synergistic blends have a negative β value or a reduced interfacial tension (IFT) when compared with an expected IFT value calculated from the individual surfactant components. Blends of the invention also exhibit surprisingly favorable solubility profiles. The surfactant blends are useful for laundry detergents, dish detergents, household or industrial cleaners, personal care products, agricultural products, building materials, oil recovery compositions, emulsion polymers, and other practical applications.
US10982169B2 Polyalkylene glycol-based lubricant composition
A lubricant composition includes: an oil selected from among polyalkylene glycols (PAG); and a nitrogen compound selected from among amine phosphates or amine tungstates. The lubricant composition is particularly suitable for lubricating a vehicle engine, preferably a motor vehicle engine. Also disclosed is an engine lubrication method utilizing such composition.
US10982167B2 Viscosity index improver and lubricating oil composition
A viscosity index improver comprising a copolymer having a unit (a) derived from a maleimide monomer and a unit (b) derived from a macromonomer, wherein viscosity measured by the following method is 8000 mPa·s or less. Viscosity measurement method: A solution composed of 78 mass % of a Group III base oil (viscosity index: 122, kinematic viscosity at 40° C.: 19.6 mm2/s) on the American Petroleum Institute (API) classification and 22 mass % of the copolymer is measured with a viscometer (TVB-10 manufactured by Toki Sangyo Co., Ltd., rotor: SPINDLE No. M3, rotation speed: 6 rpm) at 25° C.
US10982163B2 Mineral additive blend compositions and methods of use thereof
Mineral additive blend compositions and a method for operating a furnace are provided in order to avoid combustion problems such as agglomeration, deposition, corrosion and reducing emissions. A method for operating a furnace, such as a fluidized-bed reactor, pulverized-fuel combustor, and grate combustor, includes introducing fuel and a mineral additive blend including a clay and a functional mineral into the furnace.
US10982161B2 Process for producing high-carbon biogenic reagents
This invention provides processes and systems for converting biomass into high carbon biogenic reagents that are suitable for a variety of commercial applications. Some embodiments employ pyrolysis in the presence of an inert gas to generate hot pyrolyzed solids, condensable vapors, and non-condensable gases, followed by separation of vapors and gases, and cooling of the hot pyrolyzed solids in the presence of the inert gas. Additives may be introduced during processing or combined with the reagent, or both. The biogenic reagent may include at least 70 wt %, 80 wt %, 90 wt %, 95 wt %, or more total carbon on a dry basis. The biogenic reagent may have an energy content of at least 12,000 Btu/lb, 13,000 Btu/lb, 14,000 Btu/lb, or 14,500 Btu/lb on a dry basis. The biogenic reagent may be formed into fine powders, or structural objects. The structural objects may have a structure and/or strength that derive from the feedstock, heat rate, and additives.
US10982157B2 Two-step hydrocracking process for the production of naphtha comprising a hydrogenation step carried out upstream of the second hydrocracking step
The present invention is based on the use of a two-step hydrocracking process for the production of naphtha, comprising a step of hydrogenation placed upstream of the second hydrocracking step, the hydrogenation step treating the unconverted liquid fraction separated in the distillation step in the presence of a specific hydrogenation catalyst. Furthermore, the hydrogenation step and a second hydrocracking step are carried out under specific operating conditions and in particular under temperature conditions that are very specific with respect to one another.
US10982153B2 Integrated multi-stage solvent deasphalting and delayed coking process to produce high quality coke
Process embodiments for producing high grade coke and fuel grade coke from residual oil comprises: introducing the residual oil and a first paraffinic solvent having a carbon number Cn to a first solvent deasphalting unit to produce a high quality deasphalted oil (HQDAO) fraction and a first asphalt fraction; passing the HQDAO fraction to a delayed coker to produce green coke; passing at least a portion of the first asphalt fraction and a second paraffinic solvent carbon number of Cn+1 to a second solvent deasphalting unit to produce a low quality deasphalted oil (LQDAO) fraction and a second asphalt fraction; and passing the LQDAO fraction to the delayed coker to produce the fuel grade coke.
US10982152B2 Demetallization of liquid biomass
Methods, processes, systems, or apparatus are provided to remove contaminants such as metals and chlorine present in a pyrolysis stream to form reduced-contaminant liquid biomass. In certain embodiments, for example, a metal chelating agent is dissolved into a metal-containing pyrolysis stream condensate to form metal chelate complex, followed by filtering to obtain the reduced-contaminant liquid biomass.
US10982146B2 Liquid crystal composition, liquid crystal element, and use of liquid crystal composition in liquid crystal element
A liquid crystal composition including liquid crystalline compounds, polymerizable compounds, and dichroic dyes in which the polymerizable compound includes at least one compound represented by Formula (1), R11-MES-Sp11-P11  (1) in Formula (1), R11 is an alkyl group having 1 to 15 carbon atoms; MES is a mesogenic group having at least one ring, and in the ring in MES, at least one hydrogen atom is optionally substituted with -Sp11-P11; Sp11 is a single bond or an alkylene group having 1 to 10 carbon atoms, and in this alkylene group, at least one —CH2— is optionally substituted with —O—, —CO—, —COO—, —OCO—, or —OCOO—, and at least one —(CH2)2— is optionally substituted with —CH═CH— or —C≡C—, and in these groups, at least one hydrogen atom is optionally substituted with a polymerizable group; P11 is a polymerizable group or a polar group, or a group having both polymerization and polarity.
US10982140B2 Nitride phosphor particle dispersion-type sialon ceramic, fluorescent member, and method for producing nitride phosphor particle dispersion-type sialon ceramic
A nitride phosphor particle dispersion-type sialon ceramic of the present invention includes a matrix formed of a sialon-based compound; and at least one nitride phosphor which is dispersed in the matrix and contains a luminescence center element.
US10982133B2 Modified acid compositions as alternatives to conventional acids in the oil and gas industry
An aqueous modified acid composition for use in oil industry activities, said composition comprising: an amino acid, an alkanolamine and strong acid wherein the mineral acid:alkanolamine/amino acid are present in a molar ratio of not more than 15:1, preferably not more than 10:1; it can also further comprise a metal iodide or iodate. Said composition demonstrates advantages over known conventional acids and modified acids.
US10982132B2 Process of fracturing subterranean formations with water-soluble layered silicate
Method of fracturing a subterranean formation by injecting an aqueous fracturing fluid comprising an aqueous base fluid, a polysaccharide and/or polysaccharide derivative, a crosslinker, which is a water-soluble, layered silicate and a proppant. Aqueous fracturing fluid comprising an aqueous base fluid, a polysaccharide and/or polysaccharide derivative, a crosslinker, which is a water-soluble, layered silicate and a proppant and to the use of water-soluble, layered silicates as crosslinker for aqueous fracturing fluids comprising polysaccharides and/or polysaccharide derivatives.
US10982121B2 Zwitterionic crosslinked polymer-based adhesives
Disclosed are terpolymer adhesives comprising three different repeating domains: a catechol containing domain, a zwitterionic domain, and a crosslinking domain. In specific examples, the polymer can contain a 3,4-dihydroxy-L-phenylalanine (DOPA) segment which contains a catechol group, a poly(sulfobetaine methacrylate) (polySBMA), and poly(ethylene glycol) dimethacrylate (PEGDMA) for light crosslinking. Alternatively, a photocleavable nitrobenzyloxycarbonyl containing crosslinker can be used. The disclosed polymers can be used as biomedical adhesives, such as to prevent leakage from the sutured intestinal tissue.
US10982116B2 Adhesive and damping film
Adhesives including a polyester at 20 to 50 weight percent, a first tackifier at 30 to 60 weight percent, and a first olefin-styrene block copolymer at 5 to 30 weight percent are described. The polyester has a glass transition temperature between −40° C. and −10° C., and the adhesive has a heat activation temperature between 20° C. and 100° C. Damping films including at least one layer of the adhesive and including a foamed layer are described. The foamed layer includes a second olefin-styrene block copolymer at 30 to 80 weight percent and a second tackifier at 15 to 60 weight percent.
US10982115B2 Adhesive composition
An adhesive composition according to the present invention contains a polymerizable monomer (A) and a block copolymer (B) including a polymer block (a) which includes structural units derived from a styrene compound and from a maleimide compound, and an acrylic polymer block (b), in which the polymer block (a) and the acrylic polymer block (b) have a solubility parameter of 10.0 or more and 9.0 or more, respectively; the polymer block (a) contains the structural unit derived from a maleimide compound at a concentration from 30% by mass to 99% by mass with respect to the total mass of the polymer block (a); the polymer block (a) has a glass transition temperature of 150° C. or higher; and the polymer block (b) has a glass transition temperature of 20° C. or lower.
US10982114B2 Composition for conducting material removal operations and method for forming same
A composition including a carrier comprising a liquid, an abrasive particulate contained in the carrier, an accelerant contained in the carrier, the accelerant including at least one free anion selected from the group of iodide (I−), bromide (Br−), fluoride (F−), sulfate (SO42−), sulfide (S2−), sulfite (SO32−), chloride (Cl−), silicate (SiO44−), phosphate (PO43−), nitrate (NO3−), carbonate (CO32−), perchlorate (ClO4−), or any combination thereof, and a buffer contained in a saturated concentration in the carrier, the buffer including a compound selected from MaFx, NbFx, MaNbFx, MaIx, NbIx, MaNbIx, MaBrx, NbBrx, MaNbBrx, Ma(SO4)x, Nb(SO4)x, MaNb(SO4)x, MaSx, NbSx, MaNbSx, Ma(SiO4)x, Nb(SiO4)x, MaNb(SiO4)x, Ma(PO4)x, Nb(PO4)x, MaNb(PO4)x, Ma(NO3)x, Nb(NO3)x, MaNb(NO3)x, Ma(CO3)x, Nb(CO3)x, MaNb(CO3)x, or any combination, wherein M represents a metal element or metal compound; N represents a non-metal element; and a, b, and x is 1-6.
US10982113B2 Coating system
The present patent application relates to a novel coating system, wherein the coating comprises Carnauba wax and at least one polysorbate. Furthermore it relates to compositions coated with such a coating system and the use of such compositions in the production of tablets.
US10982112B2 Hydrophobic silicone coating
A hydrophobic silicone coating composition includes a trialkoxysilane with trialkoxy functionality, a polyfluorinated trialkoxysilane, and an organometallic cure catalyst. A coating on a substrate is provided that includes a cured film produced by the cure of the coating composition. The coating has a contact angle of at least 93 degrees after 500 hours of exposure to UV-A exposure in ASTM D 4329 QUV using UVA 340 bulbs, cycle B exposure of alternate cycles of UV exposure and condensing humidity all at elevated temperature.
US10982111B2 Coating composition
A coating composition comprising a resin material comprising polyester imide polymer one or more titanate material; and one or more OH reactive cross linking material.
US10982109B2 Two-component printable conductive composition
The present invention provides a two-component printable conductive composition comprising, as separate components, a metallic component comprising a high melting point (HMP) metal or metal alloy powder having a mean particle size below about 15 μm; and a fluxing component comprising an organic acid and an organic solvent. The organic acid is characterized by having at least two carboxylic groups and a first logarithmic acid dissociation constant (p Ka1) of at most about 4. These two components are manufactured and stored separately and are mixed together shortly before the combined conductive composition is used for printing. Further provided is a kit comprising the two-component composition, wherein the metallic component and the fluxing component are disposed in separate containers. The present 10 invention further provides a method for deposition and patterning of the two-component composition, comprising: mixing the metallic component with the fluxing component; and applying the obtained mixture to an insulating substrate.
US10982106B2 Information processing device, information processing method, and storage medium
An information processing device acquires information relating to a type of recording medium and outputs, on the basis of the acquired information, an instruction to display items for setting a color of a color metallic portion having color metallic luster, for recording an image by using a metallic ink.
US10982104B2 Inkjet printing apparatus and inkjet printing method
To provide an inkjet printing apparatus that improves the smoothness of the ink layer surface and improves the image quality. Provided is an inkjet printing apparatus that prints with a UV curable ink, the inkjet printing apparatus including: an ejection unit configured to eject the UV curable ink onto the surface of a print medium; and a control unit configured to control the ejection of the UV curable ink from the ejection unit, the UV curable ink containing a thixotropy-imparting agent, and the control unit setting the viscosity of the UV curable ink to 1 mPa·s to 20 mPa·s at the time of ejection and to at least 80 mPa·s within five seconds of landing on the print medium.
US10982100B2 Slippery liquid-infused porous surfaces and biological applications thereof
A self-healing, scratch resistant slippery surface that is manufactured by wicking a chemically-inert, high-density liquid coating over a roughened solid surface featuring micro and nanoscale topographies is described. Such a slippery surface shows anti-wetting properties, as well as exhibits significant reduction of adhesion of a broad range of biological materials, including particles in suspension or solution. Specifically, the slippery surfaces can be applied to medical devices and equipment to effectively repel biological materials such as blood, and prevent, reduce, or delay coagulation and surface-mediated clot formation. Moreover, the slippery surfaces can be used to prevent fouling by microorganisms such as bacteria.
US10982099B2 Resin formulation containing cure speeding inorganic particulate and use thereof as a surface marker
A surface marker resin formulation is provided that includes a linear aromatic polyester or a co-polymer thereof. The resin is dissolved or dispersed in a solvent exclusive of naphtha. An inorganic particulate having an average maximal linear extent of between 10 and 130 microns present from 22 to 41 total weight percent. A process of marking a surface includes two articles being brought into a pre-selected alignment to define a surface. A continuous bead is applied to the surface. The solvent evaporates to a state of dry-to-touch in a time of between less than 60 seconds to mark the surface. The formulation is readily applied from a pen to achieve a controlled bead width. The drying of the formulation by solvent evaporation yields full hardness in 24 hours under standard temperature and pressure as measured at 0% humidity.
US10982088B2 Polymer composition comprising poly(butylene terephthalate)
The present invention relates to a polymer composition comprising: (a) poly(butylene terephthalate); (b) glass fibres; (c) a polymer comprising moieties derived from acrylonitrile, butadiene and styrene; and (d) a polymer comprising moieties derived from ethylene, methyl (meth)acrylate and glycidyl (meth)acrylate. Such polymer composition provides a desired balance of chemical resistance, impact strength and tensile strength.
US10982084B1 Ethylene vinyl alcohol copolymer resin composition as well as films and multi-layer structures thereof
The instant disclosure relates to ethylene vinyl alcohol copolymer resin composition and/or pellets thereof including one or more fluorine-containing micro-particles. The ethylene vinyl alcohol copolymer resin compositions and/or pellets thereof may have a melting pressure of 1.7 to 7.0 MPa at a shear rate of 20 s−1 and a melting point temperature of 190° C. EVOH films formed from the EVOH may have a Charpy impact strength of at least 2.3 KJ/m2 according to ISO 179-1 at 23° C. and an elongation at break of at least 17.8% according to ISO 527-2 at 23° C.
US10982083B2 Fluorinated elastomer composition and shaped article
Disclosed is a fluorinated elastomer composition which comprises a fluorinated elastomer and fibrous carbon nanostructures, wherein the fibrous carbon nanostructures include single-walled carbon nanotubes, and the fibrous carbon nanostructures are contained in an amount of 0.1 parts by mass or more and less than 5.0 parts by mass per 100 parts by mass of the fluorinated elastomer. Also disclosed is a shaped article formed using the fluorinated elastomer composition.
US10982081B2 Hydrocarbon resins for butyl based compositions and methods of making the same
Butyl based composition having hydrocarbon resins are provided herein. The hydrocarbon resin has a Tg from −10° C. to 25° C., a number average molecular weight between 20 to 500, a weight average molecular weight between about 100 to about 2000, and a glass transition temperature between about 0° C. to about −80° C.
US10982079B2 Poly(oxyalkylene) polymer processing additive, compositions, and methods
A poly(oxyalkylene) polymer having a weight average molecular weight of at least 50,000 grams per mole and a metal salt of a carboxylic acid, sulfonic acid, or alkylsulfate, in combination are useful as a polymer processing additive. In some embodiments, the polymer processing additive further includes a poly(oxyalkylene) polymer having a weight average molecular weight of up to 20,000 grams per mole Polymer processing additive compositions and thermoplastic, for example, polyolefin, compositions including a poly(oxyalkylene) polymer and a metal salt of a carboxylic acid, sulfonic acid, or alkylsulfate are disclosed. Methods of reducing melt defects during the extrusion of a thermoplastic polymer, which may be a homogeneously catalyzed polyolefin, are also disclosed.
US10982078B2 Degradable elastomeric material
A method can include polymerizing a blend of materials where the materials include polymeric material and a degradable alloy material; and forming a degradable component from the polymerized blend of materials. Such a method can include exposing the degradable component to water where the degradable alloy material reacts with the water to at least in part degrade the component.
US10982076B2 Rubber composition for tire tread and tire manufactured using same
The present disclosure relates to a rubber composition for a tire tread, the rubber composition comprising 100 parts by weight of a raw material rubber, 10 to 30 parts by weight of a vegetable oil having a weight ratio of linolenic acid to oleic acid of 1:0.5 to 1:1.5, 10 to 20 parts by weight of a terpene-based resin having a softening point of 110 to 130° C., and 75 to 120 parts by weight of a reinforcing filler, and a tire manufactured using the rubber composition for the tire tread. The present disclosure provides a tread rubber composition for four seasons which improves the braking performance on the ice and snow road surface and the abrasion resistant performance and improves the braking performance on the wet road surface at the same time while minimizing a drop in rotational resistance.
US10982074B2 Natural rubber, rubber composition and pneumatic tire
The invention provides natural rubbers having improved processability and/or abrasion resistance, rubber compositions containing the natural rubbers, and pneumatic tires formed from the rubber compositions. The invention relates to a natural rubber which shows a 1H-NMR spectrum where the sum of peak intensities at about 4.17, 3.94, 3.84, 3.73, 3.50, and 3.41 ppm, normalized to 10,000 for the peak intensity at about 5.11 ppm, is 8.0 or less.
US10982071B2 Sulfonic acid esters as regulators in radical polymerization reactions
The invention relates to the use of sulfonic acid esters of the following Formula 1 and/or Formula 2, individually or as a mixture of more than one thereof, as regulators in polymerization reactions of radically polymerizable, ethylenically unsaturated monomers: wherein A in each case independently is selected from H, CN, linear, branched or cyclic aliphatic or aromatic C1-C30 hydrocarbon residues; X in each case independently is —COO— or —CON(R1)—, wherein the binding to A occurs via O or N, or is absent if A is an aromatic hydrocarbon residue or CN; B in each case independently is selected from linear, branched or cyclic aliphatic or aromatic C1-C30 hydrocarbon residues; R1 in each case independently is selected from hydrogen and linear, branched or cyclic aliphatic or aromatic C1-C10 hydrocarbon residues, which are optionally substituted with one or more OH groups, wherein the aliphatic hydrocarbon residues are optionally interrupted by one or more oxygen atoms; and n in each case independently is an integer from 1 to 6.
US10982069B2 Acid resistant carbon composites, methods of manufacture, and articles formed thereof
An article comprising a carbon composite containing carbon microstructures having interstitial spaces among the carbon microstructures; and a binder disposed in at least some of the interstitial spaces; wherein the carbon microstructures comprise unfilled voids within the carbon microstructures; and the binder comprises one or more of the following: polytetrafluoroethylene; polyvinyl fluoride; polyvinylidene fluoride; polychlorotrifluoroethylene; perfluoroalkoxy alkane; fluorinated ethylene propylene; ethylene tetrafluoroethylene; ethylene chlorotrifluoroethylene; a peroxide cured copolymer of tetrafluoroethylene and propylene; a fluorocarbon rubber; perfluorocarbon rubber; or a perfluoropolyether.
US10982067B2 Foam ionomer compositions and uses thereof
Components for articles of footwear and athletic equipment are provided including a foam. A variety of foams and foam components are provided. The articles include a composition having a foam structure, wherein the composition includes an ionomeric polymer and a plurality of cations, wherein the ionomeric copolymer is crosslinked by the cations. The crosslinks are ionic, so in some aspects the composition is free or essentially free of any covalent crosslinks between the ionomers. In particular, midsoles including the foams are provided for use in an article of footwear. Methods of making the compositions and foams are provided, as well as methods of making an article of footwear including one of the foam components. In some aspects, the foams and foam components can be made by injection molding or injection molding followed by compression molding.
US10982059B2 Long fiber-reinforced propylene composition for use in a thin part
A fiber-reinforced polymer composition that comprises a polymer matrix that contains a propylene polymer is provided. The polymer matrix constitutes from about 30 wt. % to about 80 wt. % of the composition, and a plurality of long reinforcing fibers that are distributed within the polymer matrix. The fibers constitute from about 20 wt. % to about 70 wt. % of the composition. The polymer composition exhibits a spiral flow length of about 450 millimeters or more as determined in accordance with ASTM D3123-09, and after aging at a temperature of 150° C. for 1,000 hours, a Charpy unnotched impact strength greater than about 15 kJ/m2 as determined at a temperature of 23° C. in accordance with ISO Test No. 179-1:2010.
US10982054B2 Polymer gel and preparation method therefor
When a polymer gel has excellent mechanical strength and an ability to maintain surface wetness for a longer time, the polymer gel may be very widely applied to a variety of fields. The present disclosure provides example embodiments of a polymer gel having excellent mechanical strength and an ability to maintain surface wetness for a longer time. Further, the present disclosure provides example embodiments of a method of preparing the polymer gel.
US10982052B2 Silicone block copolymer having an aminofunctional endblocking group and method for its preparation and use
A silicone block copolymer having an aminofunctional endblocking group is useful in personal care applications, particularly hair care. A process for making the silicone block copolymer is also described.
US10982050B2 Sealing composite material, preparation method, and application thereof
A sealing composite includes a molecular formula as follows:
US10982049B2 Polyarylene sulfide resin and manufacturing method therefor, poly(arylene sulfonium salt) and manufacturing method therefor, and sulfoxide
The present invention relates to a method for manufacturing a polyarylene sulfide resin comprising: reacting a sulfoxide represented by the following formula (1) with a particular aromatic compound to obtain a poly(arylenesulfonium salt) having a particular constitutional unit; and dealkylating or dearylating the poly(arylenesulfonium salt) to obtain a polyarylene sulfide resin having a particular constitutional unit, wherein R1 represents an alkyl group having 1 to 10 carbon atoms, etc.; Ar1 and Ar2 each independently represent an arylene group optionally having a substituent; and Z represents a direct bond, etc.
US10982048B2 Organosilicon-modified polyimide resin composition and use thereof
The present disclosure discloses an organosilicon-modified polyimide resin composition, comprising an organosilicon-modified polyimide and a thermal curing agent, wherein the organosilicon-modified polyimide comprises a repeating unit represented by the following general formula (I): wherein Ar1 is a tetra-valent organic group having a benzene ring or an alicyclic hydrocarbon structure, Ar2 is a di-valent organic group, R is each independently methyl or phenyl, and the thermal curing agent is selected from the group consisting of epoxy resin, isocyanate and bisoxazoline compounds. The resultant organosilicon-modified polyimide resin composition of the present disclosure has superior transmittance, heat resistance and mechanical strength, and is suitable for producing a flexible LED filament.
US10982041B2 Epoxy resin oligomer
An epoxy resin oligomer is provided. The epoxy resin oligomer is obtained by the reaction of at least a first reactant and a second reactant, and the molecular weight of the epoxy resin oligomer is between 3000 and 9000, wherein the mole ratio of the first reactant and the second reactant is between 1:0.9 and 0.9:1, and each of the first reactant and the second reactant is a compound having two polymerizable groups.
US10982040B2 Epoxy resin, epoxy resin composition including same, and cured product using said epoxy resin composition
The present invention provides an epoxy resin including a reaction product of 1,2,3-trihydroxybenzene and an epihalohydrin, the epoxy resin containing a cyclic compound that has acyclic structure containing, as constitutional atoms, two adjacent oxygen atoms derived from 1,2,3-trihydroxybenzene, the cyclic compound being contained in an amount of 0.040 to 0.115 mol based on 100 g of the epoxy resin. The epoxy resin can be an alternative as a biobased polymer, is liquid, and is excellent in thermal resistance.
US10982033B2 Polymer production method and radical polymerization initiating group-containing compound
The present invention provides: a novel production technique that enables production of a polymer whose molecular weight and molecular weight distribution are controlled and production of a polymer having a complicated structure in a desirably controlled manner using commercially available materials without using a radical polymerization initiator or a special material for use in living radical polymerization and without the need for strict polymerization conditions; and a radical polymerization initiating group-containing compound for use in the technique. The present invention relates to: a method for producing a polymer, the method including a polymerization step of mixing and warming (1) a radically polymerizable monomer, (2) an organic compound wherein at least one group that functions as a group for initiating polymerization of the monomer and that has a structure represented by formula 1 or formula 2 (X in the formula represents Cl or Br) is introduced in a molecule of the organic compound, and (3) an iodine-containing compound, thereby initiating, from the group having the structure, radical polymerization accompanied by a termination reaction; and the organic compound of (2) for use in the method.
US10982027B2 Injection stretch blow molded articles and random copolymers for use therein
A polymer composition adapted for use in injection stretch blow molding may include a metallocene random propylene-based copolymer in the absence of a clarifier. The metallocene random propylene-based copolymer may exhibit a melting point of from 105° C. to less than 175° C., a recrystallization temperature ranging from 85° C. to 100° C. as measured by DSC, a microtacticity ranging from 89% to 99%, a molecular weight (Mw) ranging from 170,000 to 210,000, and a melt flow rate of from about 1 dg/min. to about 40 dg/min. A method of forming an injection stretch blow molded (ISBM) article may include providing the metallocene random propylene-based copolymer, injection molding the metallocene random propylene-based copolymer in the absence of a clarifier into a preform, and stretch-blowing the preform into an article.
US10982024B2 Polymerization catalysts
Embodiments of the present disclosure directed towards polymerization catalysts having improved ethylene enchainment and/or improved catalyst productivity. As an example, the present disclosure provides a polymerization catalyst of Formula (I), wherein each of R1 to R12 is independently a C1 to C20 alkyl, aryl or aralkyl group, or a hydrogen, wherein at least one of R4 to R7 is not a hydrogen, wherein M is a Group 4 metal, and wherein, each X is independently a halide, C1 to C20 alkyl, aralkyl or hydrogen.
US10982022B2 Method of forming melt-blown non-wovens
Synergistic visbreaking composition of peroxide and a hydroxylamine ester for increasing the visbreaking efficiency for polypropylene polymers at melt extrusion temperatures below 250° C. and its use in visbreaking polypropylene. The present invention is furthermore related to the use of such visbroken polypropylene polymers for producing melt blown non-wovens with improved barrier properties.
US10982019B2 Process for catalyst deactivation
A process for the offline deactivation of at least one single site catalyst comprising contacting said catalyst with a deactivating agent selected from an aprotic low molecular weight carbonyl group containing organic compound or an aprotic low molecular weight orthoester or an aprotic low molecular weight acetal compound.
US10982017B2 Methods of manufacturing polyolefin drag reducing agents
A process of manufacturing a polyolefin drag reducing agent comprises: injecting a catalyst and a drag reducing agent forming component comprising (i) at least one olefin monomer, or (ii) at least one olefin oligomer, or a combination of (i) and (ii) into a temporary container comprising a container material, sealing the temporary container; allowing the drag reducing agent forming component to polymerize in the sealed temporary container to form the polyolefin drag reducing agent; and at least partially dissolving the container material. The container material includes an ethylene vinyl acetate copolymer, an ethylene vinyl alcohol copolymer, a polyvinylpyrrolidone, an ethylene vinylpyrrolidone copolymer, a vinylpyrrolidone vinyl acetate copolymer, a polyvinyl acetate, a polyvinyl alcohol, a polyethylene glycol, a polysaccharide or its derivative, or a combination comprising at least one of the foregoing, provided that when the container material comprises polyvinyl acetate or polyvinyl alcohol, the temporary container is coated or has two or more layers.
US10982009B2 Cellulose derivative and use thereof
To provide a cellulose derivative excellent in thermoplasticity, water resistance and strength (elastic modulus, impact strength), a cellulose derivative, which is obtained by introducing a short-chain organic group (acetyl group), a medium-chain organic group having 3 to 5 carbon atoms and a long-chain organic group having 6 to 30 carbon atoms at the following substitution degrees DSs into a cellulose, is used: Short-chain organic group: 0.7≤DSSH≤1.5; Medium-chain organic group: 0.5≤DSME≤2.0; Long-chain organic group: 0.1≤DSLO<0.5; and 2.4≤DSSH+DSME+DSLO≤3.
US10982007B2 Detection of a posttranslationally modified polypeptide by a bivalent binding agent
A bivalent binding agent having a first monovalent binder that binds to a polypeptide epitope of a target polypeptide, a second monovalent binder that binds to a posttranslational polypeptide modification on the target polypeptide and a linker. Further disclosed are methods for the detection of a posttranslationally modified target polypeptide, for making the disclosed bivalent binding agent, and for use of the disclosed bivalent binding agent in histological staining procedures.
US10982006B2 Heterodimeric antibodies that bind fibroblast activation protein
The present invention relates to novel antigen binding domains and heterodimeric antibodies that bind Fibroblast Activation Protein (FAP).
US10981993B2 Anti-PD-1 monoclonal antibody and obtaining method therefor
The invention provides human monoclonal antibodies that specifically bind to PD-1 with high affinity. The anti-PD-1 monoclonal antibodies were screened from a synthetic antibody library, and affinity maturation was performed. The synthetic antibody libraries used to select for the high affinity anti-PD-1 monoclonal antibodies were made by replacing the light chain CDR1, CDR2 and CDR3 and heavy chain CDR1, CDR 2 and CDR 3 of phage libraries from the preliminary screening, and the high affinity anti-PD-1 monoclonal antibodies were selected. The human anti-PD-1 monoclonal antibodies have high affinity and inhibit the binding of PD-1 to its ligand PD-L1. The antibodies can be used for treating tumor, inflammation and autoimmune diseases.
US10981991B2 PD-1 antibodies and uses thereof
The present invention provides monoclonal antibodies that specifically bind to human PD-1 with high affinity. Nucleic acid molecules encoding the antibodies of the invention, expression vectors, host cells and methods for expressing the antibodies of the invention are also provided. The PD-1 antibodies of the present invention inhibit the binding of PD-L1 to PD-1, thereby modulating immune responses in general, and those mediated by TcR and CD28, in particular. The invention also provides methods for treating various diseases, including infectious diseases and cancer using the PD-1 antibodies of the present invention.
US10981990B2 Antibody molecules to TIM-3 and uses thereof
Antibody molecules that specifically bind to TIM-3 are disclosed. The anti-TIM-3 antibody molecules can be used to treat, prevent and/or diagnose immune, cancerous, or infectious conditions and/or disorders.
US10981984B2 Methods of determining whether anti-PACAP antibodies inhibit PACAP-associated photophobia or light aversion
This invention relates to methods of screening for anti-PACAP antibodies, or anti-PACAP receptor antibodies, and antigen binding fragments thereof, for potential use in treating or preventing PACAP-associated photophobia or light aversion, and therapeutic compositions containing and methods of using anti-PACAP antibodies, or anti-PACAP receptor antibodies, and antigen binding fragments thereof.
US10981981B2 Compositions and methods for growth factor modulation
Provided herein are proteins, antibodies, assays and methods useful for modulating growth factor levels and/or activities. In some embodiments, such growth factors are members of the TGF-β superfamily of proteins.
US10981978B2 Compositions and methods for the therapy and diagnosis of Inflammatory Bowel Disease
Compositions and methods for the therapy and diagnosis of Inflammatory Bowel Disease (IBD), including Crohn's Disease and Ulcerative Colitis, are disclosed. Illustrative compositions comprise one or more bacterial polypeptides, immunogenic portions thereof, polynucleotides that encode such polypeptides, antigen presenting cell that expresses such polypeptides, and T cells that are specific for cells expressing such polypeptides. The disclosed compositions are useful, for example, in the diagnosis, prevention and/or treatment of IBD.
US10981976B2 Human monoclonal antibodies to human endogenous retrovirus K envelope (HERV-K) and use thereof
The present invention features anti-HERV-K monoclonal antibodies or antigen-binding portions thereof. The present invention also features uses of the antibodies for treating HIV infection or HIV-associated conditions or diseases.
US10981968B2 Fusion partners for peptide production
The present invention relates to the field of medicine, in particular, to the production of large amounts of a soluble recombinant polypeptide as part of a fusion protein comprising an N-terminal fusion partner linked to the polypeptide of interest.
US10981966B2 IL-10 variant molecules conjugated with antibody variable domain regions
The application relates to compositions or formulations comprising variant IL-10 molecules, fusion proteins, and chimeric proteins thereof useful for the treatment of cancer, inflammatory diseases or disorders, and autoimmune diseases or disorders.
US10981964B2 Fusion protein comprising IL-4 and IL-10
The invention is concerned with a fusion protein, a nucleic acid molecule encoding such fusion protein, a vector comprising such nucleic acid molecule, and a host cell comprising such nucleic acid molecule or such vector. The invention further pertains to a method for producing such fusion protein. The fusion protein or a gene therapy vector encoding the fusion protein may be used in the prevention or treatment of osteoarthritis, chronic pain, a condition characterized by local or systemic inflammation, immune activation, and/or lymphoproliferation.
US10981962B2 Modified ligand-gated ion channels and methods of use
This document relates to materials and methods for controlling ligand gated ion channel (LGIC) activity. For example, modified LGICs including at least one LGIC subunit having a modified ligand binding domain (LBD) and/or a modified ion pore domain (IPD) are provided. Also provided are exogenous LGIC ligands that can bind to and activate the modified LGIC, as well as methods of modulating ion transport across the membrane of a cell of a mammal, methods of modulating the excitability of a cell in a mammal, and methods of treating a mammal having a channelopathy.
US10981961B2 Delivery of card protein as therapy for occular inflammation
The present invention provides methods and compositions for treating and/or preventing age related macular degeneration and other conditions involving macular degeneration, ocular neovascularization, or ocular inflammation. In an exemplary embodiment, a method is disclosed that involves administering an expression vector that delivers a secretable and cell penetrating CARD to a subject in need of treatment or prevention of age-related macular degeneration or another condition involving macular degeneration or ocular neovascularization.
US10981960B2 Liver-type fatty acid-binding protein standard, method for evaluating standard, method for regulating variation range of measured value caused by liver-type fatty acid-binding protein in measurement using standard, liver-type fatty acid-binding protein, DNA encoding protein, cell transformed by DNA, method of producing protein, method of drawing calibration curve for liver-type fatty acid-binding protein, and method of quantifying protein
The purpose of the present invention is to provide: a liver-type fatty acid-binding protein standard by which, in a measurement using a specifically binding substance, the range of variation of a measured value caused by a liver-type fatty acid-binding protein can be narrowed; a method of evaluating the standard; a method of drawing a calibration curve of a liver-type fatty acid-binding protein; and a method of quantifying the protein. A liver-type fatty acid-binding protein standard in which a coefficient of change in oxidation, said coefficient being represented by the ratio of a measured value obtained by using a liver-type fatty acid-binding protein standard having been subjected to an oxidation treatment with 10 mM of an oxidant for 1 hour at 25° C. to a measured value obtained by using the liver-type fatty acid-binding protein standard not subjected to the oxidation treatment, is set to 1.4 or less; a liver-type fatty acid-binding protein to be used in the standard; a DNA encoding the protein; a cell transformed by the DNA; a method of producing the protein; a method of evaluating the standard; a method of regulating the variation range of a measured value in a measurement using the standard; a method of drawing a calibration curve for the protein; and a method of quantifying the protein.
US10981956B2 Neuroprotective peptide
A peptide fragment isolated from proline-rich protein 4 (PRP4) has a neuroprotective action. The peptide can be a neuroprotective drug in a preventive or alleviative pharmaceutical composition. The peptide can be used in a neuropathic treatment.
US10981950B2 Therapeutic protein flow kit for a continuous purification system
A compact flow kit for the continuous purification of serums containing therapeutic proteins, manufactured to minimize the risk of leakage or contamination from flexible tubing attachments.
US10981949B2 Chromatography membranes, devices containing them, and methods of use thereof
Described herein are fluid treatment devices for use in tangential flow filtration, comprising a housing unit and a composite material, wherein the composite material comprises: a support member comprising a plurality of pores extending through the support member; and a non-self-supporting macroporous cross-linked gel comprising macropores having an average size of 10 nm to 3000 nm, said macroporous gel being located in the pores of the support member. The invention also relates to a method of separating a substance from a fluid, comprising the step of placing the fluid in contact with an inventive device, thereby adsorbing or absorbing the substance to the composite material contained therein.
US10981947B2 Automatic gas valve container holder for chemical synthesis
The invention relates to a container holder 10, comprising a main body 12 which in turn comprises a gas inlet 16; a solution liquid outlet 18; a gas control valve 20 through which a gas enters the container 100 from the gas inlet; and a sealing means 22 for the container, which sealing means includes a passageway 24 for the input of gas and output of a solution in the container via an egress tube 19; wherein when the container is connected to the container holder through the sealing means, the gas control valve opens automatically, and when the container is disconnected the gas control valve is closed automatically. The invention further relates to a container panel 50 which includes two or more container holders. Also disclosed are methods of using these containers and container panels for synthesizing a polypeptide.
US10981944B2 Modulators of 5′-nucleotidase, ecto and the use thereof
Compounds that modulate the conversion of AMP to adenosine by 5′-nucleotidase, ecto, and compositions containing the compounds and methods for synthesizing the compounds, are described herein. The use of such compounds and compositions for the treatment and/or prevention of a diverse array of diseases, disorders and conditions, including cancer- and immune-related disorders, that are mediated by 5′-nucleotidase, ecto is also provided.
US10981934B2 Fused heterocyclic compound
Provided is a compound represented by the following formula, or a salt thereof: [wherein each symbol is as defined herein.].
US10981932B2 Macrocyclic indole derivatives
The present invention relates to macrocyclic indole derivatives of general formula (I): in which R1, R2, R3, R4, R5, R6, A and L are as defined herein, methods of preparing said compounds, intermediate compounds useful for preparing said compounds, pharmaceutical compositions and combinations comprising said compounds, and the use of said compounds for manufacturing pharmaceutical 2019 compositions for the treatment or prophylaxis of diseases, in particular of hyperproliferative disorders, as a sole agent or in combination with other active ingredients.
US10981930B2 Organic molecules for use in optoelectronic devices
An organic molecule is disclosed having: a first chemical unit comprising or consisting of a structure according to formula I and two second chemical moieties, each at each occurrence independently from another comprising or consisting of a structure of formula II, wherein the first chemical moiety is linked to each of the two second chemical moieties via a single bond.
US10981925B2 Self-exfoliated triazole-triformyl phloroglucinol based covalent organic nanosheets for high and reversible lithium ion storage
The invention discloses covalent organic nanosheets (CONs) made of triazole based diamine and triformyl phloroglucinol. The 2D structure of these nanosheets enables their facile amalgamation as an anodic material in a coin cell battery, which exhibits exceptionally high specific capacity of ˜720 mAh/g at a current density of 100 mA/g.
US10981924B2 Processes for the preparation of (3S,4R)-3-ethyl-4-(3H-imidazo[1,2-a]pyrrolo[2,3-e]-pyrazin-8-yl)-N-(2,2,2-trifluoroethyl)pyrrolidine-1-carboxamide and solid state forms thereof
The present disclosure relates to processes for preparing (3S,4R)-3-ethyl-4-(3H-imidazo[1,2-a]pyrrolo[2,3-e]pyrazin-8-yl)-N-(2,2,2-trifluoroethyl)pyrrolidine-1-carboxamide, solid state forms thereof, and corresponding pharmaceutical compositions, methods of treatment (including treatment of rheumatoid arthritis), kits, methods of synthesis, and products-by-process.
US10981917B2 Heterocyclic compound, its preparation method, and pharmaceutical composition comprising the same
The present invention relates to a heterocyclic compound represented by Chemical Formula 1 that can be used for the prevention or treatment of diseases caused by abnormality in a PRS (prolyl-tRNA synthetase) activity, or a pharmaceutically acceptable salt thereof, a method for preparing the same, and a pharmaceutical composition comprising the same.
US10981916B2 Substituted pyrazolopyrimidinone compounds as PDE2 inhibitors
A chemical entity of Formula (I), wherein V, W, Y, and Z, have any of the values described herein, and compositions comprising such chemical entities, methods of making them; and their use in a wide range of methods, including metabolic and reaction kinetic studies; detection and imaging techniques, radioactive treatments; modulating and treating disorders mediated by PDE2 activity; treating neurological disorders, CNS disorders, dementia, cognitive disorders, neurodegenerative diseases, and trauma-dependent losses of function, enhancing the efficiency of cognitive and motor training, including in stroke or TBI rehabilitation; and treating peripheral disorders, including hematological, cardiovascular, gastroenterological, dermatoiogical, inflammatory, and pain disorders.
US10981911B2 Imidazopyrrolopyridine as inhibitors of the JAK family of kinases
2-((1r,4r)-4-(imidazo[4,5-d]pyrrolo[2,3-b]pyridin-1(6H)-yl)cyclohexyl)acetonitrile compounds, pharmaceutical compositions containing them, methods of making them, and methods of using them including methods for treating disease states, disorders, and conditions mediated by JAK, such as inflammatory bowel disease.
US10981910B2 Biaryl kinase inhibitors
The present disclosure is generally directed to compounds which can inhibit AAK1 (adaptor associated kinase 1), compositions comprising such compounds, and methods for inhibiting AAK1.
US10981909B2 Process for preparing N-(5-(3-(7-(3-fluorophenyl)-3H-imidazo[4,5-c]pyridin-2-yl)-1H-indazol-5-yl)pyridin-3-yl)-3-methylbutanamide
Provided herein is a synthetic process for preparing a compound of Formula (1). The disclosure also provides useful intermediates and salts, amorphous and polymorph forms of the compound of Formula (1). These compounds are useful for various disease including cancer, abnormal cellular proliferation, angiogenesis, Alzheimer's disease, and osteoarthritis as well as Wnt-related diseases.
US10981908B2 Aryl hydrocarbon receptor (AHR) modulator compounds
The present invention relates to compounds which can act as aryl hydrocarbon receptor (AhR) modulators and, in particular, as AhR antagonists. The invention further relates to the use of the compounds for the treatment and/or prophylaxis of diseases and/or conditions through binding of said aryl hydrocarbon receptor by said compounds.
US10981906B2 Substituted pyrrolopyridine JAK inhibitors and methods of making and using the same
The present invention relates to new pyrrolopyridine compounds and compositions and their application as pharmaceuticals for the treatment of disease. Methods of inhibition of JAK1 and JAK3 kinase activity in a human or animal subject are also provided for the treatment diseases such as pruritus, alopecia, androgenetic alopecia, alopecia areata, vitiligo and psoriasis.
US10981905B2 Heteroaryl-substituted sulfonamide compounds and their use as therapeutic agents
This invention is directed to benzenesulfonamide compounds, as stereoisomers, enantiomers, tautomers thereof or mixtures thereof; or pharmaceutically acceptable salts, solvates or prodrugs thereof, for the treatment of diseases or conditions associated with voltage-gated sodium channels, such as epilepsy and/or epileptic seizure disorders.
US10981904B2 1,3,4-thiadiazole compounds and their use in treating cancer
A compound of Formula (I): or a pharmaceutically acceptable salt thereof, where: Q can be 1,2,4-triazin-3-yl, pyridazin-3-yl, 6-methylpyridazin-3-yl, or 6-fluoropyridazin-3-yl; R1 can be hydrogen, methoxy, trifluoromethoxy, oxetan-3-yl, 3-fluoroazetidin-1-yl, 3-methoxyazetidin-1-yl, or 3,3-difluoroazetidin-1-yl; R2 can be hydrogen or fluoro; R3 can be hydrogen or methoxy; and R4 can be methoxy, ethoxy, or methoxymethyl; provided that when R1 is hydrogen, methoxy or trifluoromethoxy, then R3 is not hydrogen, and/or R4 is methoxymethyl. The compound of formula (I) can inhibit glutaminase, e.g., GLS1.
US10981903B2 Inhibitors of c-Jun-N-terminal kinase (JNK)
The present invention provides novel compounds according to Formula (I): where Ring A, Ring B, X, L1, L2, RA, RC, RD, RE, m, n, and p are as defined herein. Compounds of the present invention are contemplated useful for the prevention and treatment of a variety of human diseases associated with kinase activity, for example, proliferative diseases, neurodegenerative diseases, metabolic disorders, inflammatory diseases, and cardiovascular diseases.
US10981902B2 5-(pyridin-3-yl)oxazole allosteric modulators of the M4 muscarinic acetylcholine receptor
The present invention is directed to 5-(pyridine-3-yl)oxaxole compounds which are allosteric modulators of the M4 muscarinic acetylcholine receptor. The present invention is also directed to uses of the compounds described herein in the potential treatment or prevention of neurological and psychiatric disorders and diseases in which M4 muscarinic acetylcholine receptors are involved. The present invention is also directed to compositions comprising these compounds. The present invention is also directed to uses of these compositions in the potential prevention or treatment of such diseases in which M4 muscarinic acetylcholine receptors are involved.
US10981901B1 Heterocyclic amides useful as protein modulators
Disclosed are compounds having the formula: wherein q, r, s, A, B, C, RA1, RA2, RB1, RB2, RC1, RC2, R3, R4, R5, R6, R14, R15, R16, and R17, are as defined herein, or a tautomer thereof, or a salt, particularly a pharmaceutically acceptable salt, thereof.
US10981898B2 Isoindolinone inhibitors of the MDM2-p53 interaction having anticancer activity
The invention provides a compound of formula (I): or tautomer or a solvate or a pharmaceutically acceptable salt thereof, wherein the various substituents are as defined in the claims. Also provided are pharmaceutical compositions containing the compounds of formula (I), processes for making the compounds and the medical uses of the compounds.
US10981897B2 Heteroaryl-1,2,4-triazole and heteroaryl-tetrazole compounds for controlling ectoparasites
The present invention provides compounds of the formula: (I) wherein: X is O or S; Q1 and Q2 are independently CR5 or N, provided at least one of Q1 and Q2 is N; Y is a direct bond or CH2; R1 is H, optionally substituted alkyl, alkenyl, alkynyl, cycloalkylalkyl, benzyl or oxetan-3-yl-CH2—; R2 is optionally substituted phenyl, pyridine, pyrimidine, pyrazine or pyridazine; R3 is alkyl or haloalkyl; R4 is optionally substituted pyridine, pyrimidine, pyrazine or pyridazine; R5 is H, alkyl, haloalkyl, cycloalkyl, alkoxy, alkoxyC(O)— or (alkoxy)2CH—; or a salt thereof. The compounds are useful for controlling ectoparasites on animals.
US10981895B2 Crystalline forms and processes for the preparation of cannabinoid receptor modulators
The present invention relates to crystalline forms of (1aS,5aS)-2-(4-oxy-pyrazin-2-yl)-1a,2,5,5a-tetrahydro-1H-2,3-diaza-cyclopropa[a]pentalene-4-carboxylic acid ((S)-1-hydroxymethyl-2,2-dimethyl-propyl)-amide (Compound 1) and pharmaceutical compositions thereof that modulate the activity of the cannabinoid CB2 receptor and are therefore useful in the treatment of CB2 receptor-mediated disorders, for example, osteoarthritis; pain; hyperalgesia; allodynia; inflammatory hyperalgesia; neuropathic hyperalgesia; acute nociception; osteoporosis; multiple sclerosis-associated spasticity; autoimmune disorders; allergic reactions; CNS inflammation for example; atherosclerosis; undesired immune cell activity, and inflammation associated with a disorder selected from: osteoarthritis, anaphylaxis, Behcet's disease, graft rejection, vasculitis, gout, spondylitis, viral disease, bacterial disease, lupus, inflammatory bowel disease, autoimmune hepatitis, and type 1 diabetes mellitus; age-related macular degeneration; cough; leukemia; lymphoma; CNS tumors; prostate cancer; Alzheimer's disease; stroke-induced damage; dementia; amyotrophic lateral sclerosis; and Parkinson's disease.
US10981893B2 Therapeutic inhibitory compounds
Provided herein are heterocyclic derivative compounds of Formula (I) and pharmaceutical compositions comprising said compounds. The compounds of Formula (I) are useful for inhibiting plasma kallikrein. Furthermore, the disclosed compounds and compositions are useful for the treatment of diseases wherein the inhibition of plasma kallikrein inhibition has been implicated, such as angioedema and the like.
US10981885B2 Tetrahydropyranyl lower alkyl esters and the production of same using a ketene compound
The present invention relates to tetrahydropyranyl lower akyl esters and specifically to tetrahydropyranyl acetates, a method for preparation thereof using ketene and use thereof as fragrances and aroma substances.
US10981882B1 Compound for inhibiting IDO, a manufacturing method and a use thereof
A compound for inhibiting IDO represented by the following general formula I, wherein a bond represented by a wavy line “” indicates the structure which represents independently a cis-isomer, a trans-isomer, or a mixture of cis- and trans-isomers; R1 and R2 are each independently selected from the group consisting of H, halogen, alkyl, alkoxyl, and haloalkyl; R3 is selected from the group consisting of cyclopentyl, cyclohexyl, piperazinyl, and piperidyl; and the substitution positions of R3 are optionally substituted at 1,2 position, 1,3 position or 1,4 position; m and n are an integer number independently selected from 0 to 5. The compound has a strong inhibiting effect on IDO and can be used to manufacture an IDO inhibitor for the prevention and/or treatment of an IDO-mediated disease with the pathologic features of the tryptophan metabolic pathway.
US10981881B2 FXR (NR1H4) modulating compounds
The present disclosure relates generally to compounds which bind to the NR1H4 receptor (FXR) and act as agonists of FXR. The disclosure further relates to the use of the compounds for the preparation of a medicament for the treatment of diseases and/or conditions through binding of said nuclear receptor by said compounds and to a process for the synthesis of said compounds.
US10981880B2 Materials for organic electroluminescent devices
The present invention relates to fluorene derivatives and to electronic devices in which these compounds are used as matrix material in the emitting layer and/or as hole-transport material and/or as electron-blocking or exciton-blocking material and/or as electron-transport material.
US10981874B2 Use of quinoline derivatives for the treatment of inflammatory diseases
The present disclosure relates to the use of a compound of formula (I) or anyone of its pharmaceutically acceptable salts, in the treatment and/or prevention of an inflammatory disease; wherein: means an aromatic ring wherein V is C or N and when V is N; Q is N or O, provided that R″ does not exist when Q is O; R′ independently represent a hydrogen atom or a group chosen among a (C1-C3)alkyl group, a halogen atom, a hydroxyl group, a —COOR1 group, a —NO2 group, a —NR1R2 group, a morpholinyl or a morpholino group, a N-methylpiperazinyl group, a (C1-C3)fluoroalkyl group, a —O—P(═O)—(OR3)(OR4) group, a (C1-C4)alkoxy group and a —CN group, and can further be a group chosen among:
US10981870B2 Methods for preparing N-(4-fluorobenzyl)-N-(1-methylpiperidin-4-yl)-N′-(4-(2-methylpropyloxy)phenylmethyl)carbamide and its tartrate salt and polymorphic form
Disclosed herein are methods for obtaining N-(4-fluorobenzyl)-N-(1-methylpiperidin-4-yl)-N′-(4-(2-methylpropyloxy)phenylmethyl) carbamide (pimavanserin) comprising the step of contacting an intermediate according to Formula (A) or a salt thereof, with an intermediate Formula B, or a salt thereof, to produce pimavanserin or a salt thereof wherein Y is —ORi or —NR2aR2b; R3 is hydrogen or substituted or unsubstituted heteroalicyclyl, R4 is substituted or unsubstituted aralkyl; X is —OR22 or —NR23R24; (wherein R22 is hydrogen or substituted or unsubstituted C1-6alkyl and one of R23 and R24 is hydrogen and the other is hydrogen or N-methylpiperidin-4-yl); and R21 is —OCH2CH(CH3)2 or F; Also disclosed herein is the tartrate salt of N-(4-fluorobenzyl)-N-(1-methylpiperidin-4-yl)-N′-(4-(2-methylpropyloxy)phenylmethyl) carbamide and methods for obtaining the salt.
US10981866B2 Chemical conjugates of Evans Blue derivatives and their use as radiotherapy and imaging agents
The present invention is directed to a compound of Formula III or a pharmaceutically acceptable ester, amide, solvate, or salt thereof, or a salt of such an ester or amide or a solvate of such an ester amide or salt: Formula III wherein the definitions of R1-R12 and L1-L4 are provided in the disclosure, wherein R13 is a chelating group comprising 177Lu, and wherein R14 is a peptide. The compounds of Formula I may be covalently bonded to a peptide via a linker to provide a compound of Formula III and thereby extend the half-life of the therapeutic compound. The invention is also directed to pharmaceutical compositions of the disclosed compounds, as well as their use in the diagnosis or treatment of diseases.
US10981864B2 Crystalline modifications of N-(4,5-bismethanesulfonyl-2-methylbenzoyl)guanidine hydrochloride and N-(4,5-bismethanesulfonyl-2-methylbenzoyl)guanidine salts
The present invention relates to novel crystalline modifications of N-(4,5-bismethanesulfonyl-2-methylbenzoyl)guanidine hydrochloride, novel N-(4,5-bismethanesulfonyl-2-methylbenzoyl)guanidine salts and their crystalline modifications and processes of manufacturing and pharmaceutical formulations thereof.
US10981857B2 Method for producing α-fluoro acrylic acid ester, and composition containing highly-pure fluorocyclopropane derivative, and composition containing highly-pure α-fluoro acrylic acid ester
The present invention provides a production method of α-fluoroacrylate ester, a composition containing a highly-pure fluorocyclopropane derivative and a composition containing highly-pure α-fluoroacrylate ester. The present invention relates to a method of producing a compound represented by the following formula (F), including subjecting a composition containing a compound represented by the following formula (A) to a purification treatment in the order of distillation and washing with an aqueous alkali solution to give a purified product containing a compound represented by the following formula (A), and subjecting the purified product to a thermal decomposition reaction, a composition containing a highly-pure compound represented by the following formula (A), and a composition containing a highly-pure compound represented by the following formula (F), wherein R may be the same or different and is a monovalent hydrocarbon group, and X is a halogen atom:
US10981848B2 Carbon dioxide electrolytic device and method of electrolyzing carbon dioxide
A carbon dioxide electrolytic device includes: an electrolysis cell including a cathode, an anode, cathode and anode flow paths, and a separator; a carbon dioxide source to supply carbon dioxide to the cathode flow path; a solution source to supply an electrolytic solution containing water to the anode flow path; at least one sensor to acquire at least one data of a data indicating a discharge amount per unit time of a liquid containing water to be discharged from at least one flow path and a data indicating a concentration of at least one ion in the liquid; a refresh material source including a gas source to supply a gaseous substance to the at least one flow path; and a controller programmed to stop the supply of the carbon dioxide and the electrolytic solution, and start supply of a gaseous substance from the refresh material source, in accordance with the at least one data.
US10981847B2 Isomerization and catalytic activation of pentane-enriched hydrocarbon mixtures
The present disclosure relates to processes that catalytically convert a hydrocarbon feed stream predominantly comprising both isopentane and n-pentane to yield upgraded hydrocarbon products that are suitable for use either as a blend component of liquid transportation fuels or as an intermediate in the production of other value-added chemicals. The hydrocarbon feed stream is isomerized in a first reaction zone to convert at least a portion of the n-pentane to isopentane, followed by catalytic-activation of the isomerization effluent in a second reaction zone with an activation catalyst to produce an activation effluent. The process increases the conversion of the hydrocarbon feed stream to olefins and aromatics, while minimizing the production of C1-C4 light paraffins. Certain embodiments provide for further upgrading of at least a portion of the activation effluent by either oligomerization or alkylation.
US10981845B2 Heavy aromatics conversion processes and catalyst compositions used therein
Disclosed are processes for conversion of a feedstock comprising C8+ aromatic hydrocarbons to lighter aromatic products in which the feedstock and optionally hydrogen are contacted in the presence of the catalyst composition under conversion conditions effective to dealkylate and transalkylate said C8+ aromatic hydrocarbons to produce said lighter aromatic products comprising benzene, toluene and xylene. The catalyst composition comprises a zeolite, a first metal, and a second metal, and is treated with a source of sulfur and/or a source of steam.
US10981836B2 Laser induced graphitization of boron carbide in air
The localized formation of graphene and diamond like structures on the surface of boron carbide is obtained due to exposure to high intensity laser illumination. The graphitization involves water vapor interacting with the laser illuminated surface of boron carbide and leaving behind excess carbon. The process can be done on the micrometer scale, allowing for a wide range of electronic applications. Raman is a powerful and convenient technique to routinely characterize and distinguish the composition of Boron Carbide (B4C), particularly since a wide variation in C content is possible in B4C. Graphitization of 1-3 μm icosahedral B4C powder is observed at ambient conditions under illumination by a 473 nm (2.62 eV) laser during micro-Raman measurements. The graphitization, with ˜12 nm grain size, is dependent on the illumination intensity. The process is attributed to the oxidation of B4C to B2O3 by water vapor in air, and subsequent evaporation, leaving behind excess carbon. The effectiveness of this process sheds light on amorphization pathways of B4C, a critical component of resilient mechanical composites, and also enables a means to thermally produce graphitic contacts on single crystal B4C for nanoelectronics.
US10981833B2 Multi-layered ceramic electronic component and method for manufacturing the same
A multi-layered ceramic electronic component has a ceramic body including a dielectric layer and an internal electrode, and an external electrode formed outside of the ceramic body and electrically connected to the internal electrode. The internal electrode includes a conductive metal and a fiber-shaped ceramic additive. For example, the fiber-shaped ceramic additive can include barium titanate (BaTiO3) and, optionally, dysprosium (Dy) and/or barium (Ba). The fiber-shaped ceramic additive may have a diameter of 10 to 200 nm, and a ratio of length to diameter of 10 to 100.
US10981829B2 Block copolymers as dispersants for alkali-activated binders
A block copolymer for use as a dispersant for mineral binder compositions, containing an alkali activating agent. The block copolymer includes at least one first block A and at least one second block B, the first block A containing a monomeric unit M1 and the second block B containing a monomeric unit M2. A proportion of monomeric units M2, if any, in the first block A is less than 25 mol %, in particular less than or equal to 10 mol %, relative to all the monomeric units M1 in the first block A, and a proportion of monomeric units M1, if any, in the second block B is less than 25 mol %, in particular less than or equal to 10 mol %, relative to all the monomeric units M2 in the second block B.
US10981828B2 High strength class C fly ash cementitious compositions with controllable setting
An embodiment includes a Class C fly ash (CFA) cementitious composition with a controllable setting time comprising at least one Class C fly ash; at least one alkali hydroxide; at least one source of phosphate; and water. Alternate embodiments include a Class C fly ash (CFA) cementitious composition with a solid activator comprising at least one Class C fly ash; at least one alkali carbonate; at least one source of phosphate; and water.
US10981827B2 Antiglare glass substrate
An antiglare glass substrate includes a glass substrate having a first main surface and a second main surface that is opposite to the first main surface. The first main surface has undergone an antiglare treatment and a fluorine-containing organosilicon compound coating film as an antifouling film is laminated thereon. The first main surface partly includes a non-antiglare-treated portion that has not undergone the antiglare treatment. The non-antiglare-treated portion has a surface roughness Ra of less than 10 nm. A difference in height along a plate thickness direction of the glass substrate between the antiglare-treated portion that has undergone the antiglare treatment and the non-antiglare-treated portion is 10 μm or larger and 200 μm or less.
US10981826B2 Solar control coatings with subcritical copper
A coated article includes a substrate, a first dielectric layer, a subcritical metallic layer having discontinuous metallic regions, a primer over the subcritical layer, and a second dielectric layer over the primer layer. The primer can be a nickel-chromium alloy. The primer can be a multilayer primer having a first layer of a nickel-chromium alloy and a second layer of titania. The subcritical layer can contain copper and silver.
US10981823B2 Lithium silicate materials
Lithium silicate materials are described which can be easily processed by machining to dental products without undue wear of the tools and which subsequently can be converted into lithium silicate products showing high strength.
US10981822B2 Device and method for producing a medical glass container
A device for producing a high-purity medical glass container from a hollow cylindrical glass blank extending along an axial direction (X) and having at least one open end, wherein the glass blank has a mouldable moulded section extending in the axial direction (X) from the open end. The device comprises a first moulding tool and a second moulding tool, where the first moulding tool has a moulding pin. The moulding pin can be moved via the open end of the hollow cylindrical glass blank in the moulded section thereof along the axial direction (X), wherein the moulding pin is fixed in a fixing unit of the first moulding tool. The moulded section can be deformed by the second moulding tool in such a way that an inner surface of the moulded section is in contact with the moulding pin, whereby the moulded section forms a channel.
US10981819B2 Variable pulsed ionic waste stream reclamation system and method
A method for treating wastewater having one or more of suspended solids, dissolved solids, biological oxygen demand includes solids filtration followed by a bi-polar/bi-directional flow through ionic module fitted with anionically/cationically charged plates followed by a sub-sonic resonance module followed by another bi-polar/bi-directional flow through ionic module followed by a ultra-sonic resonance module followed by one or more anion/cation collection membrane modules. Recycle is provided in each step, wherein each step may be repeated, and wherein one or more of the steps can be bypassed.
US10981813B2 Implementation method for eliminating harmful algal blooms through optimized utilization of modified clays
A method for eliminating harmful algal blooms through optimized utilization of a modified clay method includes building a real-time state index and a standardized value grading system for eliminating a site harmful algal bloom or a harmful algal bloom in accordance with the features of monitored harmful algal bloom organisms and modified clay flocculates; acquiring corresponding grade codes of feature index values of the harmful algal bloom in a to-be-treated water body or harmful algal bloom elimination effect through the real-time site state index and the standardized value grading system; comparing the above grade codes with an expert system to obtain an operation solution for eliminating harmful algal blooms through optimized utilization of the modified clay method. The result is tracked and monitored in real time and the operation solution is optimized and adjusted in time according to the harmful algal bloom elimination effect.
US10981811B2 Self-contained, PV-powered domestic toilet and wastewater treatment system
A wastewater treatment system and method for remediating wastewater and human waste that is self-contained and that has no connection to a municipal wastewater system and no connection to an electrical grid. The domestic toilet and wastewater treatment system can be powered by a photovoltaic panel as a source of electricity. The system includes an electrochemical cell that allows a waste stream to be disinfected in a few hours to a condition where no viable bacterial colonies can be cultured. The system produces a liquid stream that is suitable for system flushing or for uses in which non-potable water is acceptable. The system can generate hydrogen as a product that can be used to generate power. The system can generate nitrate, urea, ammonia and phosphate for use as fertilizer. The disinfected residual organic solids are also completely disinfected for potential use as an organic soil amendment for agriculture.
US10981810B2 Electro-analytical system for monitoring total organic carbon in a water source
An automated total organic carbon analyzer is described. Embodiments of the system include two features, namely the development of a selective oxidation reactor to oxidize organic contaminants to their corresponding organic acids, and the measurement of the organic acids individually by chain length using an electroanalytical detector. Combining this electroanalytical approach with sequential detection capabilities (such as spectrophotometry) can expand the instrument capabilities by providing organic contaminant speciation. The described reactor performs selective oxidation of organic carbon to organic acids followed by complexation with a proprietary ligand, then selective detection using electroanalytical accumulation and desorption of organic acids performed at an electrode surface.
US10981807B1 Disinfecting fluid using disinfection light
Fluid disinfection apparatus for disinfecting liquid. The fluid disinfection apparatus includes: a first light source assembly for generating disinfection light that has a shape of a frustum; and a container for holding fluid therein. The container includes a first frustum shell defining a space surrounded by the top, base, and inner lateral surface thereof, wherein the inner lateral surface of the first frustum shell is substantially identical to a lateral surface of the frustum of the disinfection light and wherein the first light source assembly is disposed over the top of the first frustum shell so that the entire portion of the space is substantially located within the frustum of the disinfection light.
US10981806B2 Sterilizer, supply device, and sterilization method
To provide a sterilizer preventing ultraviolet ray absorption in a body of a case body and emitting ultraviolet rays to a portion to be sterilized without involving positioning with high accuracy. A sterilizer 1a has a case body 2 containing a member having an ultraviolet-ray transmission property and a flow passage formed thereinside and an ultraviolet-ray irradiation portion 3 irradiating a predetermined portion of a member configuring the case body 2 with ultraviolet rays, in which ultraviolet rays emitted from the ultraviolet-ray irradiation portion 3 travel in a body of the case body 2 to be radiated at least from an end surface on an output end side of the case body 2.
US10981805B2 Solar humidifier in a humidification-dehumidification type desalination system
An aspect of the present disclosure relates to a solar humidifier. The solar humidifier includes a solar collector comprises perforations, wherein the solar collector exhibits an absorptance in the range of 0.70 to 0.95 when dry. The solar humidifier also includes a frame on which the solar collector is mounted, wherein the frame provides at least one opening for supplying brine to a surface of the solar collector. The solar humidifier further includes a collection box, wherein the collection box includes an interior volume and is enclosed on a side by the solar collector.
US10981800B2 Chamber enclosure and/or wafer holder for synthesis of zinc oxide
Briefly, embodiments of systems and/or methods for synthesis of zinc oxide are described, including a chamber enclosure, a wafer substrate holder, a fluid handling system, and sequences for implementation.
US10981799B2 Fine particles, dispersion liquid, and deodorizer
A fine particle in which a surface of a copper oxide fine particle (a) is coated with a coating layer (b) containing a monovalent copper compound, in which the fine particle has a specific surface area of 100 m2/g or greater, an average primary particle diameter in a range of 5 to 20 nm, and an average secondary particle diameter in a range of 5 to 50 nm, is provided.
US10981795B2 Precipitated silica
A precipitated silica is disclosed. Said precipitated silica has a BET/CTAB in a range of 0.8-1.35; a DBP oil absorption in a range of 240-320 ml/100 g; and a CDBP coefficient (DA) in range of 0.65 to 0.9. The precipitated silica has a micro pore area ranging from 6 to 35 m2/g and a micro pore volume ranging from 0.01 to 0.06 cm3/g.
US10981793B2 Electrochemical deposition for metal ion extraction/removal from water
A method for extracting metal ions from water is provided that includes disposing two electrically conductive electrodes in water, where the water includes a target ion species in solution, where at least one of the electrically conductive electrodes is a functionalized electrode having species-specific adsorption of the target ion species, and providing electrical current to the electrically conductive electrodes such that the one or more target ion species are deposited to metallic form or metal oxides at the functionalized electrode by one or more electrochemical reactions.
US10981788B2 Method for production of sulfur and sulfuric acid
A process plant including a Claus reaction furnace, a means of Claus gas cooling, a Claus conversion section, a means for Claus tail gas oxidation and a sulfuric acid section, wherein a sulfuric acid outlet of the sulfuric acid section is in fluid communication with an inlet of said Claus reaction furnace, as well as a related process. The process has the associated benefit of such a process avoiding undesired production of sulfuric acid, as well as reducing the Claus process gas volume.
US10981786B2 Process for producing compressed hydrogen in a membrane reactor and reactor therefor
A process for direct compression of hydrogen separated from a hydrocarbon source is described herein. The process comprises a first zone wherein a hydrocarbon reaction that produce hydrogen occurs, a ceramic proton conductor which under an applied electric field transport hydrogen from said first zone to said second zone, and a second zone where compressed hydrogen is produced. The heat energy generated by ohmic resistance in the membrane is partially recuperated as chemical energy in the hydrocarbon reforming process to generate hydrogen.
US10981782B2 Process for fabricating a device for detecting electromagnetic radiation having an improved encapsulation structure
A process for fabricating a device for detecting electromagnetic radiation, including an encapsulation structure including an encapsulation layer on which a relief rests, and a sealing layer, which has a local breakage in continuity at the relief.
US10981779B2 MEMS devices and methods of forming the same
A MEMS device and methods of forming are provided. A dielectric layer of a first substrate is patterned to expose conductive features and a bottom layer through the dielectric layer. A first surface of a second substrate is bonded to the dielectric layer and the second substrate is patterned to form a membrane and a movable element. A cap wafer is bonded to the second substrate, where bonding the cap wafer to the second substrate forms a first sealed cavity comprising the movable element and a second sealed cavity that is partially bounded by the membrane. Portions of the cap wafer are removed to expose the second sealed cavity to ambient pressure.
US10981777B2 MEMS transducer system for pressure and acoustic sensing
A MEMS transducer system includes a MEMS transducer device for sensing at least one of pressure signal or acoustic signal. The MEMS transducer device includes first and second diaphragms. Formed between the diaphragms are a spacer, plate capacitor elements, and electrode elements. The plate capacitor elements are coupled to the diaphragms via the spacer. An optional member may be disposed within the spacer. The distal ends of the electrode elements are coupled to a structure such as insulator element. An optional oxides may be formed within the plate capacitor elements. Pressure sensing electrode formed between the diaphragms may be coupled to the insulator element.
US10981773B2 Communion cup filler apparatus and method
A communion cup filler apparatus that fills a full tray of serving cups simultaneously within several seconds. Each of a plurality of serving cups is positioned in an associated aperture in the tray. A distributor is attached above a base. The distributor includes a plurality of sloped polygon shapes, wherein each polygon shape includes an outlet hole; The tray is aligned between the base and distributor. A liquid is poured onto the distributor and is evenly divided among the serving cups.
US10981768B2 Pressurized dispensing system including a plastic bottle and process of minimizing the formation of stress cracks in a plastic bottle
A pressurized dispensing system including a plastic bottle and a method of minimizing the formation of stress cracks in a plastic bottle that is a part of a pressurized dispensing system. In a method of manufacturing the pressurized dispensing system, a plastic bottle is filled with a liquid, a valve is crimped onto the plastic bottle, and the plastic bottle is filled with gas so as to pressurize the plastic bottle. The plastic bottle is supported only in the finish region throughout the liquid filling, valve crimping, and gas filling steps. The filled and pressurized plastic bottle is substantially free of stress cracks.
US10981766B2 Capping chuck assembly
A bottle capping chuck that uses serrated segments with a cap torque ramp angle to grip and torque a bottle cap combined with other segments that utilize holding segments both combining to eliminate slippage and stripping and holding of bottle caps during a bottle capping process.
US10981763B2 Work tool leveling system
In accordance with an example embodiment, a work vehicle may include a chassis, a linkage, a work tool, first and second actuators connected to linkage, one or more sensors, and a controller. The work tool is movably connected to the chassis by the linkage and pivotally connected to the linkage about a base axis. The work tool includes a tip positioned at a forward end of the work tool, with a tip axis parallel to the base axis and passing through the tip. The one or more sensors are configured to provide one or more signals indicative of at least one of a position, velocity, and acceleration of the work tool. The controller is configured to actuate, based on the one or more signals, the first actuator and the second actuator to level the work tool by rotating the work tool about the tip axis.
US10981760B2 Centrifugal brake mechanism
A centrifugal brake mechanism for a controlled descent device, and a drum device employing it. The brake mechanism comprises a circular wheel configured and operable to rotate about an axis of rotation, an axle extending along and rotatable about the axis inside a central cavity of the wheel and having two or more parallel shaft rods extending inside the cavity substantially perpendicular to the axis of rotation, a gear system for transferring rotations of the wheel into counter-rotations of the axle, one or more brake elements each having two or more pass-through bores for slidably mounting over the two or more parallel shaft rods, two or more springs mounted over the parallel shaft rods between the brake element and the axle, and a friction enhancement mechanism for increasing friction forces between the brake elements and the inner wall the wheel responsive to increase in angular velocity of the wheel.
US10981749B2 Half-moon lifting device
A pipe coil lifting device includes a superstructure with a central longitudinal member and at least two supports attached to opposite sides of the central longitudinal member, with two channels at the outside long-edges of the superstructure attached to the supports, with a convex upper surface attached to the supports of the superstructure.
US10981746B2 Coating film transfer tool
A coating film transfer tool may include a casing that houses a feeding reel around which a transferable tape is wound and a winding reel; and a transfer head having a main body portion arranged in a front side which is one side of a front-rear direction of the casing to extend in a left-right direction perpendicular to the front-rear direction in a front end portion and provided with a pressing edge portion adapted for transferring the coating film to a transfer target surface. The casing or a base member housed in the casing may have a protruding tip that extends to the transfer head side and is connected to the transfer head. The protruding tip may press a part of an area including a center of the left-right direction of the main body portion to the transfer target surface side in the event of a transfer.
US10981743B2 Sheet stacking device, post processing apparatus and image forming apparatus
A sheet stacking device includes a housing, a discharge tray, a lifting mechanism, a first upper surface detection part, a second upper surface detection part and a control part. The housing has a discharge port. On the discharge tray, the sheet discharged from the discharge port in a predetermined discharge direction is stacked. The lifting mechanism supports the discharge tray. The first upper surface detection part detects a first detected surface of the sheet on the discharge tray. The second upper surface detection part detects a second detected surface of the sheet on the discharge tray on a downstream side of the first detected surface in the sheet discharge direction. The control part controls the lifting mechanism based on a detection result of the first upper surface detection part and a detection result of the second upper surface detection part, and adjusts the discharge tray at a predetermined height.
US10981737B2 System and method for improved fixation of flats sequencing system linear actuator
A system of mitigating force in a mechanical system, the system comprising a frame member, a first rail connected to the frame member, a second rail connected to the frame member and extending along the frame member in parallel to the first rail, an assembly movably engaging the first and second rails, and a first bracket located between the first and second rails, with at least one first bracket attachment secured to the frame member, the first bracket sharing an upper edge with a lower edge of the first rail, such that a downward force applied on the first rail is distributed to the first bracket and the frame member via the at least one first bracket attachment.
US10981735B2 Pneumatic conveyance method for methionine
The present invention provides a method of airflow transportation of methionine that can minimize the crushing of methionine, which is characterized in that when methionine is transported as airflow using carrier gas, the flow state of methionine is a low concentration floating flow type, and the mixing ratio of methionine and carrier gas is in the range of 4 to 10 kg-methionine/kg-carrier gas. In the method of airflow transportation of methionine of the present invention, if the D50 of methionine is in the range of 150 to 425 μm, the increase rate of the fine powder can be suppressed to 1.5% or less by maintaining the mixing ratio at 4 to 10 kg-methionine/kg-carrier gas, and can be suppressed to 1% or less by maintaining the mixing ratio at 5 to 10 kg-methionine/kg-carrier gas.
US10981732B2 Device for reliably moving article from conveyor surface
A device for reliably sweeping or sorting an article from a main conveyor surface that is positioned above the main conveyor surface and includes a paddle assembly that can be adjusted for moving various different articles from the main conveyor.
US10981727B1 Conveyor idler and support structure and methods for constructing the same
This invention provides an idler for use in conveyor systems and associated shaft and support structure that reduces the potential for infiltration of contaminants into the bearing assemblies at the opposing ends of the shaft. By use of stampings, co-molded polymer with sealed metal end caps, press-fit end shafts and stamped-metal support structures a more contamination-resistant and efficiently constructed idler assembly is provided. A hollow shaft center section can be used. The polymer defines at least three sealing structures. The shaft defines a multi-piece unit, with the end shafts press-fit onto the center shaft section and held in place by the bearing subassemblies—affixed to the idler sleeve. The support framework includes three stamped and/or cut, and folded sheet metal pieces—a center section with a pair of opposing central risers that engage end shafts, and two opposing, separately attached, end risers, that engage outermost idler end shafts.
US10981722B1 Refuse hopper
A refuse hopper is disclosed which may be mounted in the bed of a pick-up truck, a flat-bed truck or on a trailer. The refuse hopper includes a horizontally disposed support frame having a rear end, a front end, a first side and a second side. A hopper is pivotally mounted on the support frame and has a front end, a rear end, a front side and a second side. The refuse hopper is selectively movable between a horizontally disposed loading position and a dumping position. A compactor plate is pivotally mounted to the hopper and is movable between an upwardly extending loading position to a refuse packing position within the hopper. The hopper has a volume of about 2-4.5 cubic yards.
US10981716B2 Insulating device
An insulating device can include an aperture having a waterproof closure which allows access to the chamber within the insulating device. The closure can help prevent any fluid leakage into and out of the insulating device if the insulating device is overturned or in any configuration other than upright. The closure may also prevent any fluid from permeating into the chamber if the insulating device is exposed to precipitation, other fluid, or submersed under water. This construction results in an insulating chamber that is substantially impervious to water and other liquids when the closure is sealed.
US10981714B2 Thermally insulated containers
A thermal conditioning wall panel 10 for use in a thermally insulating container comprises a panel body (22) having a channel (26) formed therein along one face thereof for receiving one or more thermal conditioning elements (12). At least one foot (32) is formed at the lower end of the body (22) for engagement within a socket provided on the thermally insulating container. The panel further comprises thermal conditioning element retaining elements (40) provided adjacent the longitudinal edges (29) of the channel (26), the retaining elements (40) projecting over a peripheral portion of the channel (26) for retaining the thermal conditioning elements (12) within the channel (26).
US10981713B2 Packaged products, inserts and compartments for aseptic mixing of substances, along with methods for use therewith
A package comprising a container for holding a first substance, and a product insert for holding a second substance, at least partially inserted info said container, and where the first product and the second product can be allowed to merge by external manipulation of said package. Packaged products and methods are also provided.
US10981711B2 Bag-in-box packaging
A bag-in-box packaging includes an outer box, a collapsible inner box disposed within an interior of the outer box, and a dispensing tap coupled to the inner bag. The outer box includes a side wall, a tap access feature formed in the side wall, and a removable top wall. The top wall includes overlapping first and second top flaps. The first top flap is hingedly connected to a front side of the side wall along a first tear line. The second top flap is hingedly connected to a rear side of the side wall along a second tear line. The rear side of the side wall is disposed opposite the front side. The top wall is separable from the side wall along the first and second tear lines.
US10981710B1 Take-back liner and take-back kit therefrom
A box and take-back bag liner suitable for transporting regulated and controlled medications to a disposal site are together shipped in a first configuration as a substantially flat, compact, and durable take-back kit. The take-back kit is readily assembled to a second configuration defining a bag-lined receptacle. When the receptacle requires replacement, such as when full or otherwise determined, the box and bag liner are reconfigured to a third configuration that transports the contents of the bag liner to the disposal facility. The box incorporates a double-sealed vertical side seam, an auto-folding bottom having a pair of mutually engaging notches and slits, a multi-layer top, and pre-affixed tapes and glues. The liner incorporates both a rib and groove seal and a tape seal to provide a liquid tight and tamper evident seal. The combined box and liner provide structural integrity, security, tamper resistance and evidence, and governmental regulation compliance.
US10981705B2 Dual receptacle, multi-function button system
A dual port dispenser button system which has an elastic receptacle button that includes a first latch receiver and a second latch receiver. The system includes a dispenser with a first dispensing port and a second dispensing port. The system includes a first valve including a first valve seal member and a first button latch and a second valve including a second valve seal member and a second button latch. When the button is depressed, the first valve seal member moves from a first position in which it seals the first dispensing port to a second position in which it does not seal the first dispensing port and the second valve seal member moves from a second position in which it seals the second dispensing port to a second position in which it does not seal the second dispensing port.
US10981700B2 Twist and flip lock closure
A twist and flip closure includes first and second closure portions. The first closure portion includes a top wall portion, a skirt portion, and first and second frangible connections. The first frangible connection extends around the closure circumference. The second frangible connection has first and second sections. The second frangible connection is spaced from the first frangible connection. At least a portion of the second frangible connection is located further from the top wall portion than a portion of the first frangible connection. The second frangible connection defines an area adapted to form a tab. The second closure portion includes a tamper-evident band. The closure is adapted to be opened by twisting to break the frangible connections and expose the tab and then flipping the first closure portion from the second closure portion via the exposed tab. The closure is adapted to be locked when flipped.
US10981698B2 Portable, deployable container system
A portable deployable container system has structural elements, including a base, a cover, and a set of panels, which can be manipulated into at least two container configurations. In one configuration, a container is formed by releasably securing the cover to the base to define a first volume. Some or all of the panels may be enclosed within such first volume, defining an undeployed configuration for the system. A second configuration involves removably securing some or all of the set of panels to the base and enclosing the panels with the cover, thereby deploying the system and forming a second, deployed configuration enclosing a volume larger than the first volume. Interconnections between the structural elements benefit from duckbill connections which add strength to the configurations by receiving flanges of first elements into corresponding channels of second elements formed by flared walls on such structural elements.
US10981695B2 Pallet structure with air bag structure, cabinet device with pallet structure, and method thereof
A pallet structure includes at least one bottom plate and at least one air bag. The at least one bottom plate is disposed on a bottom side of the cabinet for supporting the cabinet. The at least one air bag is detachably installed on a bottom side of the at least one bottom plate. The at least one air bag is inflated to prop the at least one bottom plate against the cabinet upwardly until at least one supporting component of the cabinet leaves away from a supporting surface, so as to effectively absorb a shock load during transportation of the cabinet.
US10981693B2 Display/vending carton
A carton with an improved dispensing feature at one end of the carton, which preserves the integrity of the carton, while enabling the display and enhanced access and vending of containers within the carton.
US10981689B2 Multiple container device
Disclosed is a dual container device comprising a bottom container comprising a first base, a top member comprising one or more first openings, and a first wall extending between the first base and the top member, a top container comprising a second base comprising one or more second openings, and a second wall extending from the second base, an intermediate wall extending either upwardly from the upper rim of the first wall or downwardly from the lower rim of the second wall, the intermediate wall for slidably receiving the container that is not attached thereto therethrough, and guides and tracks disposed on the interior surface of the intermediate wall and the exterior surface of the wall of the container received within the intermediate wall such that motion of the top container with respect to the bottom container is restricted to between an open position and a closed position.
US10981686B2 Universal winding machine for a multitude of tray designs
A machine for winding suture into a suture tray package includes a base platform with package nests, each nest including upwardly-extending locating pins. A workstation places an empty tray onto one nest. Another workstation feeds a needle with attached suture in the tray and parks the needle in the tray. A winding station for winding the suture into a tray winding channel includes a rotatable winding head with configurable suture guiding pins, a stripper plate pushing the wound suture off the guiding pins, a suture control arm with proximal and distal ends and top and bottom sides, the distal end having a front standoff and a rear standoff incorporating a suture guiding channel, and a base member mounting the arm to base platform. A lid placement station places a lid onto a nest, a lid attachment station attaches lid to tray and an offloading station removes trays from nests.
US10981680B2 3-D printed package customization
Items may be packaged for shipping or storage using additive manufacturing techniques, also known as three dimensional (3-D) printing. Packages made by such processes may be referred to as 3-D printed packages. The 3-D printed packages may be customized based on one or more items contained in the package, a recipient of the package, a sender of the package, and/or a destination location of the package. The customizations may include two-dimensional and/or three-dimensional customizations on an interior and/or exterior of the 3-D printed packages.
US10981675B2 Propeller balancing using inflight data
The present disclosure provides methods and systems for propeller balancing of an aircraft comprising a propeller. Acceleration data is obtained from an acceleration sensor coupled to the aircraft. The acceleration data is filtered using a filter to obtain propeller-specific vibration data, the filter defining a range of acceptable frequencies associated with a frequency of rotation of the propeller. The propeller-specific vibration data is compared to trend data associated with the propeller. When the propeller-specific vibration data differs from the trend data beyond a predetermined threshold, an alert indicative of a balancing need for the propeller is issued.
US10981670B2 Aerial vehicle image capturing systems
A method, system, apparatus, and/or device for capturing an image from an aerial vehicle. The method, system, apparatus, and/or device may include a boom, a motor, a propeller, a controller, a top plate, a bottom plate, and an image capturing device. The boom may be an arm that extends outwardly. The motor may be connected to an end of the boom. The propeller may be connected to the motor. The motor may be configured to rotate the propeller to lift the system, the apparatus, and/or the device into flight when the motor is engaged. The controller may be configured to control the motor. The top plate may be connected to a first end of the boom. The bottom plate may be connected to a second end of the boom. The image capturing device may be mounted to the top plate or the bottom plate.
US10981669B2 Aircraft lamp
Disclosed is an aircraft lamp including a lamp outer case constituted of a lamp housing having an opening and a cover mounted to the lamp housing in a state of closing the opening, the lamp outer case having an inner space formed as an arrangement space, and a light source disposed in the arrangement space, a portion of the lamp housing is provided as a heat sink that releases heat generated when the light source is driven to an outside of the lamp housing, the heat sink is provided with a hole forming portion, and the hole forming portion is formed with an air vent hole communicating with the arrangement space and the outside of the lamp housing.
US10981666B1 System and method for the transfer of cryogenic fluids
A system and method for the transfer of cryogenic fluid fuel includes a nozzle positionable with respect to fuel tank inlet, e.g., of an unmanned aerial vehicle (UAV), a seal to seal the area where the nozzle and inlet are connected, a collapsible and expandable bellows providing an isolation volume where the fluid is transferred from the nozzle into the inlet; a vacuum is provided in the volume to avoid accumulation of fuel or other species in the volume.
US10981664B2 Catalytic inerting system for an aircraft with multiple fuel tanks
An example ullage-recirculating catalytic inerting system includes: (i) a plurality of fuel tanks having (a) respective inert gas ports for discharging the inert gas within a respective fuel tank, and (b) respective ullage gas ports for drawing ullage gas from the respective fuel tank; and (ii) an inert gas generating system including (a) an ullage gas inlet port fluidly coupled to the respective ullage gas ports, (b) an inert gas outlet port fluidly coupled to the respective inert gas ports, (c) a catalytic reactor for chemically converting ullage gas received through the ullage gas inlet port to inert gas for discharge through the inert gas outlet port, and (d) a prime mover for moving gas through the inert gas generating system.
US10981660B2 Hybrid propulsion engines for aircraft
Hybrid propulsion engines for aircraft are described herein. An example hybrid propulsion engine includes a propulsor and a gas turbine engine to drive the propulsor during a first mode of operation. The gas turbine engine has a core air intake. The hybrid propulsion engine also includes an electric motor to drive the propulsor during a second mode of operation and a damper disposed in the core air intake of the gas turbine engine to block airflow through the core air intake during the second mode of operation.
US10981658B2 Personnel carrying devices
Apparatus and methods for supporting human external cargo from the hoist of a hoist-equipped helicopter are provided. The apparatus has at least one personal harness for supporting a user; and at least one harness segment with a top end point attachable to the helicopter hoist through an attachable fitting and at least one bottom end point directly or indirectly attachable to the personal harness. The harness segment, and the personal harness externally support the user from the helicopter hoist and allows the user to be safely suspended from the helicopter in order for work or rescue operations to be administered by the user.
US10981656B2 Device to orient a riser of a parachute
A device to orient a riser of a parachute. The device can include a twist body that is includes a slot through which the riser passes. The slot includes a twist to change the orientation of the riser from a relatively high-profile orientation to a relatively low-profile orientation. The device can also include a link to connect the riser to the suspension lines on the canopy.
US10981654B2 Beverage holder
A beverage holder is provided. The beverage holder embodies an adjustable tray clamp, an articulating arm, a self-leveling functionality and a plurality of lockable joints for enabling an adaptable stable, level, secure, and a selectively movable holder of a passenger's beverage, thereby enhancing their travel seat and overcoming typical tray space limitations.
US10981653B2 Holder assembly
A holder assembly, movable between stowed and deployed configurations, includes a holder including a flap configured to support a personal electronic device. The holder is configured to rotate between stowed and deployed positions. A latch assembly is configured to engage the holder in the stowed position, and a movement assembly is configured to automatically move the holder from the stowed position to the deployed position upon disengagement of the holder and latch assembly.
US10981650B2 Multirotor joined-wing aircraft with VTOL capabilities
A multirotor aircraft that is adapted for vertical take-off and landing. The multirotor aircraft comprises a fuselage, a tail boom that is provided with a vertical fin, a thrust producing units assembly that is provided for producing thrust in operation, at least one lower wing which comprises a lower wing inboard section that is connected to the fuselage and a lower wing outboard section that forms a lower wing tip, and at least one upper wing which is connected to the vertical fin and which forms an upper wing tip. The at least one upper wing is joined to the at least one lower wing in a joined-wing configuration.
US10981648B2 Fixed wing aircraft with trailing rotors and T-tail
An aircraft includes a canard having a trailing edge, a forward swept and fixed wing having a horizontal plane and a trailing edge, and a plurality of tilt rotors. At least one of the plurality of tilt rotors is attached to the trailing edge of the canard and at least one of the plurality of tilt rotors is attached to the trailing edge of the forward swept and fixed wing. The aircraft also includes a T-tail having a horizontal plane, where the horizontal plane of the T-tail is at a height that is higher than the horizontal plane of the forward swept and fixed wing.
US10981641B2 Tubular structure and a method of manufacturing thereof
Methods and structures are disclosed. An example method includes: rotating a tubular mandrel about a longitudinal axis of the tubular mandrel; depositing a composite material on an inner surface of the tubular mandrel to form a composite tubular member on the inner surface of the tubular mandrel; inserting and expanding an inner expandable mandrel within the composite tubular member to cause the inner expandable mandrel to press the composite tubular member against the inner surface of the tubular mandrel; curing the composite tubular member; removing the inner expandable mandrel; placing a frame within the composite tubular member; and removing the tubular mandrel so as to obtain the composite tubular member with the frame placed therein.
US10981640B2 Method and system for verification of tow end placement
A method and apparatus for managing tow end placement. A time at which movement of a tow is initiated or stopped during a layup process is detected. A latency between the time and a command time corresponding to a command to begin movement or stop movement of the tow is determined. A determination is made as to whether the latency is within a desired range. A timing offset used by a control system that controls tow layup is adjusted in response to a determination that the latency is not within the desired range.
US10981634B2 Enhanced system and method for remotely deploying boat fenders
An enhanced system and various methods for remotely deploying boat fenders from a safe and convenient location. The boat fenders, which are placed along the entire periphery of the boat, may be deployed and retracted with lines attached to winches and motors. A smart phone app may be employed to remind users to deploy boat fenders upon entering known ports, and may also deploy the boat fenders automatically.
US10981630B2 Floating mooring structure
A floating mooring structure including a framework formed by a plurality of equidistant parallel tubes, a second plurality of tubes extending through the first plurality tubes and a third plurality of tubes extending through the first plurality spaced from and below the second plurality of tubes. The structure also includes peripheral berthing beams and additional flotation tanks with shock-absorbing fenders and with vent tubes that help stabilize the structure and serve as mooring posts for vessels.
US10981629B2 Gear shift controller and gear shifting system
A gear shift controller includes a detection circuit and a control unit. The detection circuit is configured to determine traveling state information about a traveling state of a human-powered vehicle. The control unit is configured to receive the traveling state information from the detection circuit to control a shift standby time of a transmission of the human-powered vehicle. The traveling state information includes information other than traveling speed information about a traveling speed of the human-powered vehicle and crank information about crank rotation information of the human-powered vehicle.
US10981627B2 Integrated control device and integrated handlebar for bicycle
An integrated handlebar for a bicycle includes a handlebar and at least one integrated control device, wherein the handlebar has at least two free ends and the integrated control device includes a base engaged with at least one of the free ends, a brake lever and an electronic controller. The brake lever has a front end pivotally connected with the base and a rear end. The brake lever has a mounting portion, being located at a distance not greater than ¾ length of the brake lever from the rear end and not on the rear end. The electronic controller includes an operation member disposed on the brake lever, which includes at least one operation part adapted to be triggered by fingers of a rider to control an action of the operation member so as to drive the electronic controller to output an electronic signal to an electronic component.
US10981625B2 Bicycle rear derailleur
A bicycle rear derailleur or gear changer may include a mounting portion mountable to a bicycle frame, an electrical portion attached to the mounting portion and including power supply alignment and attachment features, and an electrical cable electrically connected to the electrical portion and electrically connectable to a printed circuit board (PCB) of a movable member movably coupleable to the mounting portion. The mounting portion and the electrical portion may be formed of different materials.
US10981619B2 Small-sized saddle riding vehicle, and rigidity adjustment device of body frame of vehicle
In a rocking vehicle, a front wheel suspension device suspends a front wheel in an upwardly displaceable manner due to a reaction force from a road surface. The rocking vehicle includes a cushion support arm, on a body frame side, including a cushion support portion of the front wheel suspension device, and a rigidity adjustment device which is extended between plural portions of the cushion support arm. The rigidity adjustment device applies a pre-tension to the cushion support arm, and the pre-tension generates a pre-force component in the cushion support portion in the same direction as the upward moving direction of the front wheel due to a reaction force of the front wheel from the road surface.
US10981616B2 Resin-made fuel tank
A resin-made fuel tank includes: a resin-made fuel tank body provided by bonding an upper half body and a lower half body to each other; and a barrier sheet layer provided on an inner surface of the fuel tank body and provided for reducing permeation of fuel from the fuel tank body, wherein an edge of the barrier sheet layer is disposed in a vicinity of an upper bonding surface and a lower bonding surface where the upper half body and the lower half body are bonded to each other in a mating manner, the edge has a bent portion which bends toward an outside of the fuel tank body, and the bent portion is embedded in the fuel tank body at a position spaced apart from the upper bonding surface and the lower bonding surface.
US10981612B2 Flanged master track pin with retaining ring
A master link box for use with a link assembly of a work machine is disclosed. The master link box may include first and second master links with pin bores and lateral annular recesses disposed around the pin bores, a master link pin with a radial projection at a proximal end and a distal annular groove in the outer circumferential surface near the distal end, and a master retaining ring. The master link pin may be inserted through either master link until the radial projection of the master link pin abuts the lateral recess of one of the master links. The master retaining ring may be secured in the distal annular groove to prevent the master link pin from retracting through the master link box. The master retaining ring may be secured in the distal annular groove without press-fitting the master retaining ring.
US10981610B2 Air guiding device for a motor vehicle, comprising a fixed part and a moveable part
The air guiding device for a motor vehicle, having a fixed part intended to be fixed to the motor vehicle, and at least one moveable part mounted on the fixed part, the moveable part being rotatably moveable relative to the fixed part between a rest position and an extended position, the moveable part comprising a first air guiding surface and a second air guiding surface, approximately opposite to the first air guiding surface, the first air guiding surface guiding the airflow when the moveable part is in the rest position. The second air guiding surface guides the airflow when the moveable part is in the extended position.
US10981598B2 Vehicle control apparatus controlling motor for steering based on steering condition
A control apparatus calculates an axial force deviation, which is a difference between an ideal axial force and an estimated axial force. The ideal axial force is based on a target pinion angle of a pinion shaft configured to rotate in association with a turning operation of steered wheels. The estimated axial force is based on a state variable (such as a current value of a steering operation motor) that reflects vehicle behavior or a road condition. The control apparatus changes a command value for a reaction motor in response to the axial force deviation. For example, the control apparatus includes a basic control circuit configured to calculate a basic control amount, which is a fundamental component of the command value. The basic control circuit changes the basic control amount in response to the axial force deviation. The command value based on the basic control amount reflects the road condition.
US10981596B2 Steering controller
A control steered angle calculation unit includes: an end position determination unit that determines whether a rack shaft is located at either one of right and left rack end positions; a motor absolute angle calculation unit that detects a motor absolute angle; an end position-corresponding motor angle setting unit that, when the rack shaft is determined to be located at either one of the right and left rack end positions, sets the detected motor absolute angle as an end position-corresponding motor angle corresponding to the one of the right and left rack end positions; and a control steered angle origin setting unit that calculates an average value of right and left end position-corresponding motor angles as an offset angle, and sets an angle obtained by subtracting the offset angle from the detected motor absolute angle as an origin of the control steered angle represented by the motor ab solute angle.
US10981592B2 Ball nut assembly for a power steering assembly of a vehicle
A power steering assembly has a housing and a ball nut assembly supported on the housing. The ball nut assembly has a ball nut axis. The housing has a first surface between the housing and the ball nut assembly. The ball nut assembly also has a second surface. The second surface rotates on the first surface such that the ball nut assembly rotates relative to the housing on a rotation axis that is transverse to the ball nut axis.
US10981588B1 Versatile article support device
A versatile transport rack uses a pair of end frames that are each pivotally attached to a connector frame on opposing sides thereof thereby forming an article support device. Each frame has casters removably attached thereto. One or more vertical frames and/or one or more relatively flat base plates are removably attached to an upper surface of the versatile transport rack. Hinge pin receiver pairs are attached to the vertical frame and receive door pin pairs of a vehicle door.
US10981587B2 Removable hand truck lift system
A removable lift for a hand truck for providing lifting functions to a traditional hand truck. The removable lift includes a motor for causing a toe plate to move up or down. The motor and moving toe plate may be operated using a control panel.
US10981582B2 Rail vehicle, in particular locomotive
A rail vehicle, in particular a locomotive, includes a railcar body having a head end provided with a front nose. The railcar body has an interface, in the region of the head end, which is configured and provided for fastening and connecting differently shaped front noses forming a set of variations. A front nose selected from the set of variations is thereby fastened to the interface by a welded connection. The rail vehicle therefore permits more flexibility in the shaping of the head end of the railcar body.
US10981581B2 Display device
A display device includes an image display unit that displays a first alert image in response to an alert at a first level, an image projection unit that displays a second alert image in response to an alert at a second level. The second image display unit overlaps the first image display unit. The first alert image appears at a position different from a surface of the second image display unit.
US10981575B2 System and method for adaptive advanced driver assistance system with a stress driver status monitor with machine learning
A system in a vehicle, comprising one or more physiological sensors configured to obtain stress-load data indicating a stress load of an occupant of the vehicle, a controller in communication with the one or more physiological sensors, wherein the controller is configured to determine a stress load of the occupant utilizing at least the stress-load data and output an instruction to execute a vehicle driving-dynamics features when the stress load exceeds a threshold, wherein the vehicle driving-dynamics features includes adjusting an active suspension of the vehicle.
US10981572B2 Method of controlling driving force of vehicle
A method of controlling driving force of a vehicle includes estimating a first maximum road surface frictional coefficient based on a driving stiffness defined by a micro slip ratio and driving force of drive wheels, in a first driving state where the vehicle travels straight at a constant acceleration, estimating a second maximum road surface frictional coefficient based on a steering reaction force detected by an electric power steering device, in a second driving state different from the first state and where the vehicle is steered, estimating a third maximum road surface frictional coefficient to be a given value in a third driving state different from the first and second states and where an outdoor air temperature is above a determination temperature, and controlling the driving force to settle within a friction circle defined by each of the highest frictional coefficients and a ground contact load of the drive wheels.
US10981554B2 Fluid delivery system
A system for delivering fluid in a machine is provided. The system includes a pump, a first valve disposed downstream of the pump, a check valve disposed downstream of the first valve, at least one accumulator disposed downstream of the check valve, and an auxiliary system disposed upstream of the check valve. The system further includes a control unit configured to receive a signal indicative of a fluid demand from the auxiliary system. The control unit is also configured to selectively control the first valve in a first position to limit flow of the fluid from the pump to the auxiliary system, and in a second position to allow flow of the fluid from the pump to the auxiliary system based, at least in part, on the received signal. The check valve limits flow of a fluid from the at least one accumulator to the auxiliary system.
US10981552B2 Vehicle brake system
A brake system includes first and second wheel brakes, a reservoir, and a brake pedal unit having a housing and a pair of output pistons slidably disposed in the housing. The output pistons generate brake actuating pressure during a manual push-through mode for actuating the first and second wheel brakes. The system further includes a plunger assembly having a housing having a motor driving an actuator, and a piston connected to the actuator. The piston pressurizes a chamber when the piston is moving in a first direction to provide fluid flow out of a first port and through a pair of parallel valves. The piston pressurizes a second chamber when the piston is moving in a second direction opposite the first direction to provide fluid flow out of a second port. The first and second ports are selectively in fluid communication with the wheel brakes.
US10981551B2 Valve unit for modulating the pressure in a pneumatic brake system
A valve unit for modulating pressure in a pneumatic brake system includes an inlet valve and an outlet valve, which are designed as diaphragm valves, and via which a brake pressure outlet can be connected to a brake pressure inlet or a vent outlet or can be shut off relative thereto. The valve unit further includes two pilot valves, designed as 3/2-way solenoid valves, via each of which a control chamber adjoining a diaphragm of an associated diaphragm valve can be supplied with a control pressure via a control pressure line. The diaphragm valves are arranged radially adjacent to each other. The inlet valve and/or the outlet valve is/are each designed as a springless diaphragm valve and in that the associated control pressure line opens, in each case centrally and in an axially oriented manner, into the control chamber of the relevant diaphragm valve.
US10981543B2 Wiper subassembly for a motor vehicle
A wiper subassembly for a motor vehicle has a windshield wiper retention member connected by a front connection arrangement in the longitudinal direction of the motor vehicle to a first bodywork component and by a rear connection arrangement to a second bodywork component. In order to optimize the crash behavior of a wiper subassembly, the front connection is arranged to be configured, when a threshold force which acts in the longitudinal direction between the windshield wiper retention member and the first bodywork component is exceeded, to give way so that the first bodywork component can be moved to the rear relative to the windshield wiper retention member.
US10981536B2 Multi-point seat belt assembly
A multi-point seat belt assembly has a buckle assembly, two webbing-locking mechanisms, two main webbings, and at least one retractor. The buckle assembly has a buckle member and a tongue member detachably inserted into the buckle member. The webbing-locking mechanisms are mounted on the buckle assembly, and each webbing-locking mechanism has a connecting member and a movable member mounted moveably on the connecting member. The connecting members of the two webbing-locking mechanisms are connected respectively with the buckle member and the tongue member. The main webbings are mounted respectively through the webbing-locking mechanisms and each main webbing has an end. The at least one retractor is connected with the ends of the two main webbings.
US10981532B2 Vehicle trim component
A component for a vehicle interior is disclosed. The component may comprise a structural substrate, an airbag chute and a structure coupling the chute and structural substrate. The structure may comprise a rib injection molded onto the structural substrate; the structure may be bonded to the structural substrate. The chute may be welded to the structure and/or the structural substrate. The structural substrate may comprise a panel comprised of fibers; the structure may be comprised of resin. The structure may comprise an interface bonding the chute and structural substrate; the interface may comprise a molded feature/resin feature/mounting area on the structural substrate; a structure/material/rib injection molded on the structural substrate; a bond; an attachment; a composite or resin material; a material comprising fibers; polypropylene with fibers. The component may comprise a trim component; an instrument panel; a trim panel.
US10981529B2 Energy absorption device for an occupant in vehicle seat
A restraint system for a vehicle is disclosed. The restraint system includes a seat shaped to accommodate an occupant, wherein the seat includes a seat back and an energy absorption member that expands from a stowed position and into a deployed position. The energy absorption member fills a volume of space behind the seat back when in the deployed position to absorb energy that would otherwise be imparted towards an occupant of the seat during an impact involving the vehicle. The restraint system also includes an impact sensing device generating an impact signal in response to detecting the impact involving the vehicle is imminent. The impact signal indicates an orientation and magnitude of the impact involving the vehicle. The restraint system includes a control module in electronic communication with the energy absorption member and the impact sensing device.
US10981526B2 Split vehicle power busses
A system includes a first DCDC converter arranged to output electrical power only to a first battery and to first loads in a first specified set. The first specified set includes loads provided to control and perform steering and braking. The system further includes a second DCDC converter arranged to output electrical power to loads isolated from the first loads provided to control and perform steering and braking.
US10981525B2 Rotary connector device
A rotary connector device capable of reducing the number of components and enhancing assembly workability provided with: a stationary member; a rotary member to be attached to the stationary member to be capable of relative rotation with respect to the stationary member, the rotary member including a steering wheel insertion hole into which an insertion convex portion of a steering wheel is to be inserted; and an intermediate stationary member provided to be movable between a locked position and a lock released position with respect to the rotary member, wherein the intermediate stationary member is provided with a regulating portion, the regulating portion being configured to, at the locked position, regulate relative rotation of the rotary member when the regulating portion is engaged with the stationary member.
US10981522B2 Binding structure of wire routing material
Elongated wire routing materials are bound by a first-side binding member on a first side in the longitudinal direction of the wire routing materials, and are bound by a second-side binding member on a second side opposite to the first side. An engaging member includes an engaging portion for assembly into a vehicle body, and an attachment portion serving as the part to which the wire routing materials are attached such that the attachment portion is slidable relative to the wire routing materials in the longitudinal direction. At least one of the engaging portion and the attachment portion comes into contact with the first-side binding member at the first side, and at least one of the engaging portion and the attachment portion comes into contact with the second-side binding member at the second side.
US10981515B2 Seat carrier for long guns
A long gun carrier rests on a vehicle seat, and is secured to the seat by a seat belt. An upper, sloping surface of the long gun carrier slopes generally downward and forward. One or more gun-holding channels formed in this sloping surface each hold a long gun pointed generally forward and downward, toward the vehicle floor. The long guns may be secured in the gun-holding channels by straps. Long guns are conveniently placed into and extracted from the long gun carrier, held securely during transportation, pointed in a safe direction, and not readily visible from the exterior.
US10981513B2 Center console structure
A center console structure includes a columnar part erected on a vehicle interior floor surface between a driver seat and a passenger seat and extends upward to the vicinity of the cushion surfaces of the seats and an upper body that is disposed above the columnar part, extends in a front-rear direction, has an upper surface part forming a center console surface, and accommodates a shift operation mechanism, in which the upper body extends forward of the columnar part that is cantilevered and has an extension part that is bent and then rises forward and obliquely upward in the front part thereof, a surface part of the extension part close to a sitting occupant forms an outer surface continuous with the center console surface and a portion of the extension part close to the front of the vehicle is locked to a rear projecting part of an instrument panel.
US10981510B2 Interior rearview mirror assembly with full screen video display
A dual-state interior rearview mirror assembly includes a mirror head including an electro-optic mirror reflective element having a transflective mirror reflector. A video display device is disposed rearward of the viewable reflective region and occupies at least 75 percent of the viewable reflective region of the mirror reflective element. With the mirror assembly operating in a first state, the video display device does not display video images and the driver views rearward via reflection at the viewable reflective region and, with the mirror assembly operating in a second state, the video display device displays video images at the display screen for viewing at the viewable reflective region by the driver. Video images displayed by the display screen at a center zone of the viewable reflective region are at unit magnification, and video images displayed at driver-side and passenger-side zones are not displayed at unit magnification.
US10981508B2 Vehicle door mirror
A vehicle door mirror includes a mirror housing accommodating an electrical component therein, a base member made from a resin, and a shaft having a cord through hole through which a cord that is to be connected to the electrical component is inserted, the shaft being standingly provided on the base member so as to pivotably support a base end portion of the mirror housing. The base member has a slit formed therein. The slit has an outer end opening on a side edge of the base member so that the cord guided out from the cord through hole toward the base member side can be inserted through the slit. A linking part that links paired mutually opposing side faces of the slit together via an inner end part of the slit is formed on the base member so as to have a shape protruding downward.
US10981505B2 Auto switching of display mirror assembly
A blocked imager detection system includes a rearview assembly having an actuator device. The actuator device is adjustable to tilt an electro-optic element, thereby moving the electro-optic element to an off-axis position which changes an activation state of a display module. The actuator device is also adjustable to tilt the electro-optic element in another direction, thereby moving the electro-optic element to an on-axis position which changes the activation state of the display module. An imager is configured to capture image data of a scene external to the controlled vehicle and to generate image data for display on the display module. When a controller determines that the operational capability of the imager to capture image data is at least partially diminished, the controller can generate a control signal indicating that imager performance has been compromised and deactivate the display module.
US10981501B2 Sound output device and sound output system
A sound output device for installation at a vehicle is provided with a warning sound generation section configured to generate a warning sound including at least one sine wave, a background sound generation section configured to generate a volume-adjusted first background sound based on a selected sound source, a controller configured to control selection of a sound source of the first background sound based on externally-supplied selection information, and a first synthesizer section configured to combine the warning sound and the first background sound and output the combination as a first advisory sound.
US10981497B2 Control system of autonomous vehicle and control method thereof
A control system of an autonomous vehicle may include: a camera unit installed on a vehicle body, and configured to take an image of a pedestrian; a measurement unit installed on the vehicle body, and configured to measure a position of the pedestrian and a distance to the pedestrian; a control unit configured to receive data of the camera unit and the measurement unit; and an image irradiation unit configured to operate according to a control signal of the control unit, and irradiate light to one or more of the pedestrian and a road.
US10981495B2 Display control method and display control device
A display control device includes: a turn signal installed in a vehicle; indicators for displaying a lighting state of the turn signal to an occupant of the vehicle; and a controller for controlling the lighting state of the turn signal and a lighting state of the indicators. The controller makes timing of starting to turn on the turn signal and timing of starting to turn on the indicators different from each other.
US10981492B1 Apparatus and method for controlling beam pattern of head lamp for vehicle
An apparatus for controlling a beam pattern of a head lamp for a vehicle, comprising: an object detection unit configured to detect an object ahead of a vehicle; an ADB (Adaptive Driving Beam) head lamp configured to emit a matrix beam according to a beam pattern; a vehicle state input unit configured to receive an ADB operation state; and a control unit configured to calculate the width of a dark zone corresponding to the object and a boundary section around the dark zone according to the object detection result from the object detection unit, and then drive the ADB head lamp according to the ADB operation state.
US10981490B1 Positioning apparatus for cargo securing implement
A positioning apparatus that is configured to assist in the placement of cargo securing chains or similar elements so as to secure a cargo load. The positioning apparatus includes a cable having a first end and a second end. The first end of the cable is secured to a weight member. The second end of the cable is secured to a mounting plate. The mounting plate of the present invention is planar in manner having an upper peripheral edge that is arcuate in form. The mounting plate has a first aperture proximate the upper peripheral edge. A pair of lower apertures are formed in the mounting plate along the lower edge thereof. A first fastener and a second fastener are operably coupled to the pair of lower apertures. Chains are secured to the first fastener and second fastener.
US10981488B2 Vehicle for lifting, transporting, and lowering load carriers
A vehicle has at least two axles, each having at least one wheel for lifting, transporting, and lowering load carriers. A first axle is mounted in a chassis. Lifting elements are provided for lifting and lowering the load carriers. The distance of the second axle relative to the first axle can be changed in the horizontal longitudinal vehicle direction, and the lifting elements are lifted or lowered by a change in the distance of the second axle from the first axle. The at least one wheel of the first axle can be driven by a drive motor that is arranged on the chassis, and at least one lifting element is displaced horizontally inward or outward by the change in the distance of the second axle from the first axle in the transverse vehicle direction.
US10981487B1 Hitch mounted lift gate system with pivoting door-access drop feature and method of loading and unloading a payload
A hitch mounted lift gate system and method of loading and loading a payload from a cargo vehicle using the lift gate system. The frame and platform of the lift gate system is pivotable relative to the hitch and hitch receiver as between a vertical use position and a horizontal dropped position for facilitating opening and closing of rear doors on the vehicle to which the lift gate system is mounted when the rear doors pivot about a vertical axis.
US10981486B2 Automatic parcel accumulation transfer system
Parcel processing systems and methods. A parcel processing system includes a boom conveyor section configured to extend into a loading area, transport parcels into the loading area, and adjust a height of a discharge end of the boom conveyor section. The parcel processing system includes a sensor pod configured to scan the loading area into which the parcels can be placed. The parcel processing system includes a control system configured to determine a placement of the one or more parcels in the loading area, arrange the one or more parcels on the boom conveyor section according to the determined placement, control the boom conveyor section to transport one or more parcels into the loading area, control the height of the discharge end of the boom conveyor section, and place the one or more parcels into the loading area in the determined placement.
US10981479B2 Armrest assembly for a vehicle door and door assembly and vehicle including same
An armrest assembly for a vehicle door can include a panel and a cover panel. The panel can include an upper exterior surface, a pull pocket extending from and recessed below the upper exterior surface, a first engagement aperture in the pull pocket, a second engagement aperture in the pull pocket, and a switch spaced away from the pull pocket. The cover panel can include an exterior touch surface for an occupant to pull on the vehicle door. The cover panel can be in the pull pocket and expose the upper exterior surface of the panel. The cover panel can include a snap element engaging with the first engagement aperture, the snap element attached to the interior surface of the cover panel, and an attachment element engaging with the second engagement aperture, the attachment element attached to the interior surface of the cover panel.
US10981475B2 Seat air-conditioning system
A seat air-conditioning system includes a plurality of seat air-conditioning devices respectively disposed for seats. Each of the seat air-conditioning devices achieves comfortable air conditioning in a vehicle interior by a controller controlling a refrigeration circuit, a blower, and a blowing switching portion in each seat air-conditioning device. A coordinating flow path is disposed to fluidly connect the blowing switching portion of one seat air-conditioning device to the blowing switching portion of the other seat air-conditioning device. The seat air-conditioning system performs the air conditioning for one seat by using the two seat air-conditioning devices by supplying conditioned air via the coordinating flow path under control of the controller.
US10981471B2 Fuel cell system, vehicle including fuel cell system, and control method of fuel cell system
A fuel cell system includes: a fuel cell outputting generated power to an external load; a secondary battery outputting charged power to the external load; and a controller performing a first control that controls output power of the fuel cell and output power of the secondary battery such that the output power of the secondary battery has a ratio predetermined in accordance with an output demand from the external load, in the power supplied to the external load, the controller switches the first control to a second control when the output demand satisfies a predetermined condition with which the output power of the secondary battery is predicted to reach a limit value with the first control, the second control sets a target value of the output power of the fuel cell such that the output power of the secondary battery is smaller than that in the first control.
US10981470B2 Electric utility terrain vehicle
A utility task vehicle (UTV) includes a frame having frame rails and a battery assembly positioned laterally between the frame rails. The battery assembly includes a battery housing and a battery array having a plurality of battery cells. The battery array is positioned within the battery housing and the battery assembly provides support for or is located under a floor of a cabin of the utility task vehicle.
US10981465B2 System, and method for swapping self driving energy module for an energy management system
A system includes energy modules that output power to an energy management bus based on load demands. An energy module includes energy cells enclosed within a module housing that provide power to the energy management bus and a driving system attached to the module housing that transports the energy module. The energy module includes a local controller that controls power output from the energy cells to the energy management bus, engages a self-driving mode in response to receiving a disconnection signal from a central controller, and controls movement of the energy module in the self-driving mode to a predetermined location via the driving system. The central controller receives a current module status from the energy modules and controls a configuration of the energy modules providing power to the energy management bus based on the current module status.
US10981463B2 Autonomous transport vehicle charging system
A charging system for autonomous transport vehicles including at least one charging contact disposed on each pick floor level of a storage and retrieval system, each of the at least one charging contact being located at a transfer station, at least one power supply configured to supply power to the at least one charging contact, and a controller in communication with the transfer station and being configured to communicate information relating to a transfer of items between the transfer station and a predetermined one of the autonomous transport vehicles and to apply power from the power supply to the at least one charging contact for charging the predetermined autonomous transport vehicle corresponding to the transfer and located at the transfer station, wherein the controller is configured to supply power to the charging contacts simultaneously with the predetermined autonomous transport vehicle exchanging items related to the transfer at the transfer station.
US10981459B1 Charging system for electric vehicles in motion
Disclosed herein is a charging system for electric vehicles while in motion. A retractable power charger coupled to an electric vehicle has a blade extendable between a retracted and extended position. The tapered sides of the blade contact rails in a trench when the blade is in the extended position and provide power for charging the electric vehicle while in motion. The blade can be automatically extended by a sensing system (e.g., magnetic) or by user actuation.
US10981454B2 Battery module, battery pack including battery module, and vehicle including battery pack
Disclosed is a battery module, which includes a plurality of battery cells stacked one another and respectively having electrode leads protruding in the front and rear directions of the battery module, and a bus bar unit configured to integrally connect the electrode leads of the plurality of battery cells.
US10981447B2 Transfer
To provide a transfer (10) capable of reducing its length in the axial direction.The transfer (10) comprises: a first device (51) separably couples a first gear (21) to an input shaft (11) or a first output shaft (12) and a second device (52) separably couples a second gear (22) to the input shaft (11) or the first output shaft (12).The first gear (21) and the second gear (22) are disposed axially between the first device (51) and the second device (52).
US10981446B2 Adjustable bracket for attaching a tank to the underside of a vehicle or trailer
This invention provides an adjustable bracket that can be used to attach auxiliary fuel tanks and other tanks to the bottom of a trailer or vehicle. The adjustable nature of the bracket allows it to be used on a variety of trailers, with different widths. The adjustable bracket comprises two parts with one sliding inside of the other. Each part has several slots that can be lined to create a bracket that is the ideal length to span the distance between the side panels of a trailer or vehicle. The bracket has holes in the bottom through which the bracket can be attached to a mounting retainer or strap that holds the tank in place.
US10981444B2 Shutter device
A shutter device includes fins made of a plurality of plate-shaped members. Each of the fins is configured to switch between a state of blocking an air flow and a state of not blocking the air flow, a frame is configured to rotatably support the fins, and a link member is configured to transmit a driving force to each of the fins to operate the fins. Each of the fins is provided with a support protrusion rotatably supported by the frame, and a driving protrusion rotatably supported by the link member. A plurality of supporting grooves that accommodate the support protrusions therein are formed in the frame to recess along a predetermined direction. The link member prevents the support protrusion from being removed from the supporting groove.
US10981443B2 Motor vehicle front end
A motor vehicle front end has a heat exchanger and a cooling-air mechanism for controlling a supply of air to the heat exchanger. The cooling-air mechanism includes: a downwardly opening air inlet opening; and an air flap, which corresponds to the air inlet opening, and which, at its top edge, is articulatable on a body part in a pivotable manner via a pivot joint. The air flap is configured such that, in its closed position, it closes off the air inlet opening, and in its operative position, it opens up the air inlet opening, and as seen in a direction of travel of the motor vehicle, is situated in front of the air inlet opening.
US10981435B2 Air vent having a control device
An air vent has at least one first control lamella that is pivotably mounted in a housing, and a second lamellae extending orthogonally to the first control lamella. For controlling the amount and direction of outflowing air, an operating element is pivotable mounted about an axis that extends parallel to the pivot axis of the second lamellae, and which is coupled to a first adjustment element and to the first control lamella. The first adjustment element has a toothed segment, which is in engagement with a first gearwheel that is rotatably mounted on the housing. The first gearwheel is in engagement with a second adjustment element that is arranged on a second control lamella of the second lamellae, wherein the second control lamella is coupled with the other second lamellae by way of at least one connection rod, and the second gearwheel is of spring-mounted design.
US10981433B2 Method and system for personalized thermal comfort of occupants in a vehicle and vehicle implementing the method
Methods and systems are provided for personalized controlling of an air temperature in a vehicle. A computer implemented method for personalized controlling of an air temperature in a vehicle comprises determining, by a processor, a current temperature condition in the vehicle, wherein the current temperature condition in the vehicle is determined based on at least a temperature value that is representative for a current thermal environment in a compartment of the vehicle. The processor further determines a basal metabolic rate that is associated with a person located in the compartment of the vehicle and controlling, by the processor, a desired air temperature in the vehicle, wherein the desired air temperature is controlled based on the determined current temperature condition in the vehicle and the determined basal metabolic rate.
US10981430B2 Roof-type air conditioner for vehicles and method of controlling the same
A roof-type air conditioner for vehicles may include an evaporator to discharge cold air to the internal of a vehicle, and a conveying unit to move the evaporator in a longitudinal direction of the vehicle on a ceiling of the vehicle such that the evaporator is disposed to the ceiling of the internal of the vehicle and positioned to a region required for cooling.
US10981429B2 Electronically controlled sway bar damping link
A sway bar system is described. The sway bar system includes a sway bar having a first end and a second end. The sway bar system further includes a first electronically controlled damper link which is coupled to the first end of the sway bar. The first electronically controlled damper link is configured to be coupled a first location of a vehicle. The sway bar system also has a second link which is coupled to the second end of the sway bar. The second link is configured to be coupled a second location of the vehicle.
US10981428B2 Sleeve-type freewheel with torque limitation for two-wheeled vehicle starter applications
An active wheel suspension element has a ball screw drive having a screw drive with a threaded spindle and a spindle nut which is mounted in a housing via an axial bearing. The axial bearing is formed as a rolling bearing, whose rolling element rolls directly on the spindle nut.
US10981426B2 Suspension device for vehicles
A suspension device for vehicles (a front suspension (10)) is disclosed in which, of connecting portions (23, 24) of a lower arm (20) and a tie rod (6) for connection to a knuckle (35), one of the connecting portions (24) which is close to the rear of the vehicle is offset inward in the vehicle width direction with respect to the other connecting portion (23) which is close to the front of the vehicle, in the steering neutral state. The center (P2) of a lower end portion of a coil spring (60) is offset outward in the vehicle width direction and rearward in the vehicle's longitudinal direction with respect to the center (P1) of an upper end portion of the coil spring (60).
US10981422B2 Tire noise reduction
A tire has four circumferential grooves. Grooves are on the vehicle installation inner side of the tire, and on the vehicle installation outer side of the tire. Grooves which are on the vehicle installation inner side each have a plurality of fences in the groove arranged alternately along the groove next to each side wall of the groove. Grooves which are on the vehicle installation outer side do not have fences. The fences increase the path length of sound due to pipe resonance and delay the sound in comparison to grooves on the vehicle installation outer side of the tire. This directs the sound towards the inner side of the tire and reduces the noise on the outer side.
US10981417B2 Pneumatic tire with carcass ply comprising plurality of partly overlapping strip-shaped ply pieces
A pneumatic tire 1 comprises a carcass 6 comprising at least one carcass ply 6A extending between bead portions 4 via sidewall portions 3 and a tread portion 2. The carcass ply 6A comprises strip-shaped ply pieces 11 longer in a tire radial direction than in a tire circumferential direction arranged circumferentially. Each of the ply pieces 11 comprises a plurality of carcass cords 12 arranged in parallel in the tire radial direction and at least partly overlapping each other with the ply pieces 11 circumferentially adjacent. At least one of the carcass cords 12 arranged in at least one of side edge portions 11e in the tire circumferential direction of each of the ply pieces 11 having a diameter (Ce) smaller than a diameter (Cc) of at least one of the carcass cords 12 arranged in a center portion 11c of each of the ply pieces 11.
US10981414B2 Paint can squeegee apparatus
Various embodiments are described for a squeegee apparatus configured to facilitate a removal of paint or other debris in an annular recess of a can, such as a paint can. The squeegee apparatus may include a body having a first recess to receive a first lip of a can, a second recess to receive a second lip of the can, and a projection to extend into an annular recess of the can. The squeegee apparatus may include a guard wall projecting laterally from the body and a ramp at least partially defined by a distal end of the projection. The ramp and the projection can be positioned such that, when the body of the squeegee apparatus is pulled along the annular recess of the paint can, paint or other debris residing in the annular recess is forced up the ramp and redirected towards an interior chamber of the can.
US10981409B2 Mirrored fluorescent security feature
A credential with one or more security features is disclosed. The disclosed credential includes a windowed security feature. The windowed security feature is taught to include a mirror element positioned in proximity with a transparent window and a first photo-luminescent feature positioned relative to the transparent window and the mirror element such that the mirror element enhances a luminescence of the first photo-luminescent feature when viewed and illuminated through the transparent window.
US10981406B2 Security feature
A security feature for protecting valuable documents, in particular for ensuring the authenticity of valuable documents, comprises a luminescent pigment which has a host lattice doped with a first luminophore and a second luminophore, with an excitation energy of the first luminophore being transferable to the second luminophore. However, in the case of the luminescent pigment according to the invention, the excitation energy is not transferred completely from the first luminophore to the second, but rather only partially. The incomplete transfer of the excitation energy is achieved by selecting suitable amount-of-substance fractions of the first and the second luminophores on the luminescent pigment. As a result of the incomplete transfer of the excitation energy, the luminescent light that is emitted by the luminescent pigment also has, in addition to a luminescence peak of the second luminophore, a luminescence peak of the first luminophore.
US10981405B2 Recording medium substrate and recording medium
A recording medium substrate in an aspect of the present invention is a recording medium substrate having a base paper and a stretched film layer on the base paper, wherein the stretched film layer has a thickness of 70 μm or more, and the recording medium substrate has an average surface roughness of 0.3 μm or less. A recording medium in another aspect of the present invention includes a recording medium substrate, a first ink receiving layer on the recording medium substrate, and a second ink receiving layer on the first ink receiving layer, wherein the first ink receiving layer is in contact with the second ink receiving layer, the first ink receiving layer contains an alumina hydrate and a hydroxy acid, the second ink receiving layer contains an alumina hydrate and a sulfonic acid.
US10981404B2 System and apparatus for producing multilayered printed matter
A multilayered printed matter is made up of a plurality of layers formed on a medium, including a front layer and a back layer with patterns printed thereon, and a white layer and a black layer interposed between the front layer and the back layer so as to conceal the back layer to be invisible from the front-layer side. The system for producing the multilayered printed matter includes a computer that executes a printing step of moving the medium and an inkjet head relative to each other using a moving device and printing the front, back, white, and black layers on the medium using the inkjet head, and a cutting step, subsequent to the printing step, of moving the medium and a cutting blade relative to each other using the moving device and cutting the medium using the cutting blade.
US10981403B2 Fabric print media
The present disclosure is drawn to a fabric print medium. The fabric print medium can include a treated fabric base substrate, an adhesion promoting layer, and an image-receiving layer. The treated fabric base substrate can include a fabric base substrate having a water proofing treatment including a water-repellant agent applied thereto. The adhesion promoting layer can be applied to the treated fabric base substrate. The adhesion promoting layer can include a first polymeric binder and a physical networking component. The image-receiving layer can be applied to the adhesion promoting layer. The image-receiving layer can include a second polymeric binder and a particulate filler.
US10981401B2 Apparatuses and processes for producing optical effect layers comprising oriented non-spherical magnetic or magnetizable pigment particles
The present invention relates to the field of magnetic assemblies and processes for producing optical effect layers (OEL) comprising magnetically oriented non-spherical magnetic or magnetizable pigment particles on a substrate. In particular, the present invention relates to magnetic assemblies and processes for producing said OELs as anti-counterfeit means on security documents or security articles or for decorative purposes.
US10981400B2 Printers
A printer (5) operable to print a message in strokes on a substrate (7) passing in a print direction (8) along a moving line (6), wherein the printer is operable (15) to receive an indication of an allowable increase in length in the print direction of a message due to an increase in length in the print direction of gaps between successive strokes printed by the printer, to receive (14) an indication (9) of a speed of movement in the print direction of a moving line, to determine from the indication of the speed of movement of the moving line whether an increase in length in the print direction of a message printed by the printer is greater than the allowable increase in length and, if so, to generate an alert.
US10981394B2 Method for printing a varying pattern of landing zones on a substrate by means of ink-jet printing
The object of the invention, which relates to a method for printing a substrate by means of inkjet printing, is to enable precise printing of a landing point matrix, which is displaced, rotated, or distorted, particularly not linearly distorted, as compared to an ideally orthogonal landing point matrix, with less complexity. Said object is achieved in that the lateral resolution is selected to be large enough that the smallest distance between nozzle lines is less than the minimum distance between the landing zone rows, and that, with a variation, specified by the substrate, of the distance of adjacent landing zone rows between various landing zone lines (distortion), the position of the landing zones of a landing zone line is determined relative to the nozzle lines and consequently only the printhead nozzles having a nozzle line intersecting a landing zone are actuated according to a nozzle actuation scheme and the corresponding landing zone type.
US10981393B2 Liquid ejecting apparatus and maintenance method thereof
A liquid ejecting apparatus includes: a recording head that ejects liquid; a pressurizing mechanism that supplies the liquid under pressure; a valve-mechanism provided between the pressurizing mechanism and the recording head, the valve-mechanism including a liquid storage chamber storing the liquid supplied under pressure, a pressure chamber that is provided closer to the recording head than to the liquid storage chamber and stores the liquid, and a valve body that moves in a valve opening direction according to a negative pressure in the pressure chamber to communicate the liquid storage chamber with the pressure chamber; and a pressure control section controlling a pressure of the liquid supplied from the pressurizing mechanism to the valve-mechanism. The pressure control section controls the pressure of the liquid that is supplied under pressure by the pressurizing mechanism to the liquid storage chamber, to move the valve body in the valve opening direction.
US10981391B2 Liquid container and liquid ejecting apparatus
In a state in which a liquid storage body is installed in a liquid ejecting apparatus, at least part of the upper edge of a liquid storage section and at least part of the lower edge of the liquid storage section are in contact with a case and a first inner surface of the liquid storage section and its second inner surface opposite to the first inner surface are separated from each other. The liquid storage section is structured so that as a liquid is supplied, the first inner surface and second inner surface gradually approach each other and, at the same time, come into contact with each other from top to bottom, forming, at the bottom of the interior of the liquid storage section, a liquid flow path through which the liquid flows from the liquid storage section to the liquid supply section.
US10981390B2 Liquid container and liquid injection apparatus
The liquid container comprises: a first chamber that is surrounded by a plurality of walls and is configured to contain a liquid; a liquid inlet port for pouring the liquid into the first chamber; an air opening port that is opened to air; a liquid lead-out port that leads the liquid out of the first chamber; an air lead-in port that is formed in, out of the plurality of walls surrounding the first chamber, a first wall different from the wall constituting a top surface; and an air communication path that allows the air opening port and the air lead-in port to communicate with each other. The air lead-in port is separated from a corner portion where the first wall crosses with another wall.
US10981385B2 Cleaning liquid for aqueous ink
The present invention relates to a cleaning liquid for a water-based ink that contains a pigment and a water-insoluble polymer, said cleaning liquid containing (A) a surfactant, (B) a water-soluble organic solvent containing (b-1) diethylene glycol monoisopropyl ether, and water, in which the surfactant (A) contains at least one compound selected from the group consisting of (a-1) an acetylene glycol or an ethyleneoxide adduct of the acetylene glycol, and (a-2) a polyethylene glycol alkyl ether containing an alkyl group having not less than 8 carbon atoms or a polyethylene glycol aryl ether containing an aryl group having not less than 6 carbon atoms, and a content of the water-soluble organic solvent (B) in the cleaning liquid is from 5 to 30% by mass; and a method of cleaning a water-based ink using the cleaning liquid.
US10981383B2 Liquid ejecting head and liquid ejecting apparatus
A liquid ejecting head includes a nozzle plate having a plurality of nozzles, and a flow path plate bonded to one side of the nozzle plate, the flow path plate having flow paths including a liquid reservoir configured to store a liquid to be supplied to the nozzles, in which the liquid reservoir is defined by a concave portion disposed on a side of the flow path plate opposite to the nozzle plate, a bottom of the concave portion includes a first portion along a periphery of the concave portion and a second portion inside the first portion in plan view from a thickness direction of the flow path plate, and the thickness of the first portion is thicker than the thickness of the second portion.
US10981378B2 Image-forming apparatus, non-transitory computer-readable medium storing computer-readable instructions, and method for discharging deposits on a filter of an image-forming apparatus
The disclosure provides an image-forming apparatus which can remove deposits on the filter. If there is input via operation buttons indicating that ink supply paths are closed off, a CPU drives a pump while a nozzle cleaning valve and an exhaust waste fluid valve are open, and an atmospheric valve and a nozzle waste fluid valve are closed. The pressure in an exhaust waste fluid flow path and inside an exhaust cap becomes negative, such that cleaning fluid flows from a cleaning fluid bottle into a cleaning fluid flow path, a nozzle cleaning valve, a cleaning fluid flow path, a nozzle cap, a filter, an ink supply flow path, and an exhaust flow path. Therefore, deposits adhered to the filter from the ink passing through the filter separate from the filter due to the cleaning fluid passing through the filter, and these deposits flow into the exhaust flow path.
US10981377B2 Apparatus and method for control or monitoring a printing system
Embodiments of the present invention relate to control apparatus and methods of a printing system, for example, comprising an intermediate transfer member (ITM) and to user-related features of a printing system. Some embodiments relate to regulation of a velocity and/or tension and/or length of the ITM. Some embodiments relate to regulation of deposition of ink on the moving ITM. Some embodiments regulate to apparatus configured to alert a user of one or more events related to operation of the ITM. Some embodiments relate to a time-line GUI for visualizing and/or manipulating queued print jobs which may be employed. Some embodiments relate to a reversed augmented reality GUI for visualization and/or control of the printing system. In some embodiments, a display screen is mounted to a printer housing and/or able to control access to moving parts of a printing system.
US10981375B2 In situ monitoring of direct ink write process using electromagnetic resonant coupling
In the additive manufacturing process, a monitored or controlled mixture of materials is deposited to form an additive manufactured product by delivering the mixture of materials through a material flow path while using an excitation source to introduce electromagnetic energy into the material flow path using a circuit element having inductive or capacitive reactance disposed adjacent the material ejecting orifice. The excitation source produces an electromagnetic field condition within the material flow path that is responsive to at least one of the permeability and permittivity properties of a space within the material flow path. A sensing means coupled electrically or magnetically to the excitation means is responsive to the electromagnetic field condition and provides at least one control parameter based on the electromagnetic field condition that may be used to control the composition of the mixture of materials by adjusting proportions of constituent materials.
US10981373B2 Additive manufacturing techniques and systems to form composite materials
A printer system may include a coaxial extruder head that extrudes a core, a bulk, and/or a core and bulk cladding to form complex structures without retooling. The coaxial extruder head may include a distribution channel with an entrance and an exit, a priming chamber that surrounds the distribution channel. The priming chamber may include an outlet and a first inlet, a heating element thermally connected to the priming chamber, and a nozzle connected to the outlet of the priming chamber. Further, the nozzle may converge from the outlet of the priming chamber to an orifice of the nozzle. In addition, the exit of the distribution channel may be disposed at the orifice of the nozzle. This structure facilitates extruding a core and cladding type composite from the extruder head.
US10981372B2 Ability to three-dimensionally print an aperture mask on a multi spectral filter array
A three-dimensional inkjet printer and method for printing an aperture mask on a multi-spectral filter array. A custom tray is used by the printer allowing for printing on a prefabricated filter array. Photopolymer resin is deposited on the prefabricated filter array to form the aperture mask of dark mirror coating. An ultraviolet lamp illuminates the deposited photopolymer resin on the surface of the prefabricated multi-spectral optical filter array to cure the resin, thereby forming the mask. The prefabricated multi-spectral optical filter array includes an optical coating on at least one side, the aperture mask being formed on the optical coating, without the use of heat, chemical etching, or deformation of the optical coating.
US10981371B2 Protected graphics and related methods
An improved protected graphics assembly according to the invention comprises the following sequential layers: optionally, at least one adhesive layer; at least one graphics layer; and at least one outwardly exposed polymer layer that is essentially free of low surface energy materials and has a gloss value of greater than 90 when tested according to ASTM D2457-03 at a 60-degree angle. The assembly is beneficially applied to a variety of articles and used in a variety of related methods. In an exemplary embodiment, a race car comprises a protected graphics assembly that comprises: optionally, at least one adhesive layer; at least one outwardly exposed polymer layer that is essentially free of low surface energy materials; and at least one graphics layer substantially protected from exterior exposure by the polymer layer.
US10981369B2 Method and installation for joining a cover layer to an object, as well as cover layer suitable for the method
A method and installation for joining a cover layer to an object in a continuous process. Joining is effected with the aid of a joining material having thermoplastic properties, wherein the joining material is arranged between the cover layer and the object and is liquefied using ultrasonic vibration energy. Before application of the ultrasonic vibration energy, the joining material is preheated in a contactless manner with the aid of electromagnetic induction in the region of the glass transition temperature of the joining material or above this glass transition temperature. The object is in particular a chip board and the cover layer an edge strip to be joined to an edge of the chip board.
US10981367B2 Applicator device for a protector covering and its application
Disclosed herein is an applicator device for applying a protective covering for an electronic device, comprising: a plate, a back piece and an opening on a top surface of the plate; wherein the opening is sized to fit around a raised section of an electronic device; wherein the opening and the back piece forms a chamber to allow the protective covering for a raised section of the electronic device to fit inside; wherein a depth of the chamber is greater than a depth of the protective covering. Disclosed herein is a method of using the applicator device, comprising removing a top sheet from the applicator device, aligning a perimeter of the opening to a perimeter of the raised section for allowing the protective covering to align and cover the raised section, exerting a pressure to release the protective covering from the back piece so that the protective covering is adherent to the raised section.
US10981365B2 Polymeric materials
A component comprises a first part and a second part, wherein said second part is in contact with said first part, wherein: (i) said first part comprises a polymer having a repeat unit of formula —O-Ph-O-Ph-CO-Ph-  I and a repeat unit of formula —O-Ph-Ph-O-Ph-CO-Ph  II wherein Ph represents a phenylene moiety; and (ii) said second part comprises a metal.
US10981363B2 Shrinkable label film, a shrinkable label and a method for providing a shrinkable film and a label
The invention relates to a shrink face film and a shrink label comprising said face film. According to an embodiment the shrink face film includes a first skin layer and a second skin layer comprising propylene terpolymer(s) between 1 and 99 wt. %, and a core layer comprising random copolymer(s) of propylene or propylene terpolymer(s), and a modifier, which is at least one of the following: olefinic plastomer, olefinic elastomer and ethylene-octene block copolymer. The invention further relates to a method for providing a shrink face film and a method for labelling of an item with a shrink label comprising said face film.
US10981362B2 Method to produce a veneered element
A method to produce a veneered element, the method including applying a first layer on a substrate, applying a second layer on a veneer layer, applying the veneer layer with the second layer applied thereto on the first layer, such that the second layer is facing the first layer, pressing the first layer, the second layer and the veneer layer together to form a veneered element, thereby material originating from the second layer permeates into the veneer layer, and wherein, after pressing, the first layer is visible through a crack, cavity, hole and/or knot of the veneer layer. Also, a veneered element.
US10981356B2 Adhesive sheet
An adhesive sheet includes: a carbon nanotube sheet including a plurality of carbon nanotubes aligned preferentially in one direction within a plane of the sheet; and an adhesive agent layer including an adhesive agent, the adhesive agent layer being curable.
US10981353B2 Absorbent composite
An absorbent composite of the present disclosure includes an aggregate of small pieces having a shape with a longitudinal direction, including fibers and a water absorbent resin, in which when a total length in the longitudinal direction of the small piece is L1 [mm] and a distance between end points connecting one end and the other end of the small piece is L2 [mm], an average value of L2/L1 is greater than 0 and 0.950 or less.
US10981351B2 Composite cloth
A composite cloth includes a fabric sheet and a film unit. The fabric sheet has bottom and top surfaces and a plurality of micropores extending through the bottom and top surfaces. The film unit includes bottom and top cover films respectively disposed on the bottom and top surfaces of the fabric sheet. Each of the first and second cover films includes opposite film bottom and top surfaces, and a plurality of film sections connected to each other. Each of the film section includes a pair of longitudinal trough portions, a pair of transverse trough portions connected between the longitudinal trough portions, and a crest portion surrounded by and protruding from the longitudinal and transverse trough portions.
US10981350B1 Wood-grained polymer substrate
A wood-grained polymer substrate includes a plurality of layers of different colors. The substrate is formed into elongated boards and used in the production of various end products similar to natural wood.
US10981346B2 Processed slabs, and systems and methods related thereto
This document describes systems and processes for forming improved synthetic molded slabs suitable for use in living or working spaces (e.g., along a countertop, table, floor, or the like).
US10981338B2 Method of controlling air temperature for making seals
A method and apparatus for making bags from a film that follows a film path through a bag machine includes an input section located on the film path, a sealing section located on the film path down stream of the input section, an output section located on the film path downstream of the sealing section, and a controller, connected to control the sealing section. The sealing section includes a sealer that includes a heater block and a manifold. There is an air flow path from the heater block to the manifold. Air is heated in the heater block in response to a control signal provided by the controller to the heater block. The heated air is provided through the air path to the manifold. A temperature sensor is disposed in at least one of the air path and the manifold.
US10981334B2 Heating mechanisms for build volumes
An example method for cooling a build volume is described. In one implementation, a heating mechanism is set to a temperature identified based on the build material information, and the build volume is heated using the heating mechanism for a time period identified based on the build material information.
US10981328B2 Modular systems and methods for performing additive manufacturing of objects
A modular system for performing additive manufacturing of an object includes at least two additive manufacturing devices, each having a housing with two slots on lateral sides to accommodate a manufacturing tray; a printer head and axis system; and a movement mechanism. A control module is operatively coupled to each of the at least two additive manufacturing devices. The control module is configured to control the at least two additive manufacturing devices to arrange the manufacturing tray in a first of the at least two additive manufacturing devices; print a part of the object on the manufacturing tray arranged in the first additive manufacturing device; move the manufacturing tray having the partially manufactured object to a second of the at least two additive manufacturing devices; and print a remaining part of the object on the manufacturing tray to complete the additive manufacturing of the object.
US10981327B2 Head and system for continuously manufacturing composite tube
A method is disclosed for additively manufacturing a composite structure. The method may include coating a continuous strand with a matrix, discharging a composite tubular structure made from the coated continuous strand, and exposing the matrix in the composite tubular structure to light to cure the matrix during discharging. The method may also include depositing a material layer onto an internal surface of the composite tubular structure as the composite tubular structure is being discharged, and wiping a squeegee over the material layer.
US10981323B2 Energy delivery with rotating polygon and multiple light beams on same path for additive manufacturing
An additive manufacturing apparatus includes a platform, a dispenser to deliver a plurality of layers of feed material, one or more light sources configured to emit a first light beam and a second light beam, and a polygon beam scanner including a rotatable mirror having a plurality of reflective facets to redirect the first light beam and the second light beam toward the platform to deliver energy to an uppermost layer of feed material. The mirror is positioned and rotatable such that motion of each facet of the plurality of reflective facets causes the first light beam to sweep along a first path on the uppermost layer and causes the second light beam to sweep along the first path following the first light beam.
US10981313B2 Closing unit for a shaping machine
A closing unit for a shaping machine includes mutually moveable mold mounting plates suitable for carrying mold tool portions, a first hydraulic cylinder adapted to apply a closing force to the mold mounting plates, a second hydraulic cylinder, and a pressure storage device connected to the first hydraulic cylinder and adapted to store a pressure prevailing in the first hydraulic cylinder upon pressure relief at a storage device pressure. A hydraulic interconnection of the pressure storage device with the second hydraulic cylinder allows the storage pressure stored in the pressure storage device to be used for locking and/or unlocking the locking device.
US10981310B2 Method of manufacturing radar transparent cover for vehicles and radar transparent cover manufactured thereby
A method of manufacturing a radar transparent cover may include steps of: injection molding a first transparent cover; inserting into a mold the first transparent cover made by the step of injection molding the first transparent cover and then, double injection molding a color resin on a back surface of the first transparent cover; and inserting into a mold the injection molded article made by the step of double injection molding the color resin and then, double injection molding a second transparent cover on a front surface of the first transparent cover.
US10981305B2 Apparatuses for dispensing potting material
A potting-press assembly for injecting potting material into at least a portion of a workpiece comprises a chassis and a potting press, pivotally coupled to the chassis. The potting-press assembly also comprises a control unit, fixed to the chassis and configured to cause the potting press to be selectively pressurized.
US10981302B2 Peroxide cross-linking and high temperature melting
Methods of making oxidation and wear resistant polymeric materials using peroxide cross-linking and high temperature melting process are disclosed. A multiple step procedure for enabling the manufacturing of such material without size limitations is also disclosed.
US10981300B2 Induction heating system for molding a thermoplastic article and method for molding a thermoplastic article
An induction heating system for molding a thermoplastic article includes a first mold and a second mold defining a mold cavity therebetween for molding the thermoplastic article, a first metallic susceptor as part of or adjacent to the first mold, a first armature-supported induction coil array in proximity to the first metallic susceptor, and a first induction generator electrically coupled with the first armature-supported induction coil array.
US10981297B2 Post-consumer scrap film recycling system and process
A system and method for processing a supply of post-consumer scrap linear low density or low density polyethylene film into near-virgin quality blown film product. The method includes tearing the supply of film in a shredder, wherein the surface area of the film is exposed, including delaminating the film. The torn supply of film is washed in a water bath including a surfactant. The film is agitated in the bath containing the surfactant wherein contaminants on the film are removed from the film. The washed film is ground into smaller pieces and additional washing of the ground film in a rotating friction washer and a sink float tank occurs wherein additional contaminants are removed from the film. The ground film is then dried and compacted without addition of water into granulated objects of near-virgin quality blown film product.
US10981296B2 System and method for preheating a thermoplastic charge
A system and method for preheating a thermoplastic charge are disclosed. A gas moving unit establishes a flow of a gas through a conduit. A heating assembly is positioned between an inlet and an outlet of the conduit. A holding vessel is in fluid communication with the conduit and houses a thermoplastic particulate material. The thermoplastic particulate material includes a thermoplastic matrix material. The thermoplastic particulate material is introduced to the flow of the gas to yield a gas-particulate mixture. At least one of the gas and the gas-particulate mixture, moving through the conduit, is heated using the heating assembly to yield a heated gas-particulate mixture. The heated gas-particulate mixture is deposited into a mold from the outlet of the conduit.
US10981294B2 Headbox and forming station for fiber-reinforced cementitious panel production
A slurry feed apparatus for depositing a slurry upon a moving forming web having a direction of travel, including: a headbox mounted transverse to the direction of travel of the moving web, having a back wall, sidewalls, a concave transverse front wall, an open top, and an open bottom for directing slurry onto the forming web; a moveable dam releasably attached to the back wall, a seal attached to a bottom wall of the dam; and a headbox support system extending from opposed the sidewalls. Also disclosed is a continuous process for depositing a uniform layer of a cementitious slurry containing reinforcing fibers from the headbox onto a traveling web.
US10981290B2 Workpiece transportation system and workpiece transportation method
A workpiece transportation system includes a machining palette that is able to move while holding a cut workpiece including a product and the remainder; a supporter that receives the workpiece from the machining palette and supports the workpiece; a suction attacher disposed on the supporter and attaches by suction to at least the product in the workpiece supported by the supporter; and a gripper that separates the remainder from the product attached to by suction by the suction attacher.
US10981287B2 Tube cutter with automatically feeding function and with enhanced torque
A tube cutter includes a main body, a holder slidably mounted on the main body, a guide bolt rotatably mounted on the main body and locked onto a lower portion of the holder to drive and move the holder forward or backward by rotation of the guide bolt, and a driving handle removably mounted on the guide bolt to drive and rotate the guide bolt, and to enhance the torque of the tube cutter.
US10981283B1 Double-sided ball slide knife blade locking mechanism
A knife having a double-sided ball slide knife blade locking mechanism includes a blade pivotally attached to a handle, the blade having a pair of large circular indentations formed on opposite lateral sides of the blade, and also having a pair of small circular indentations formed on opposite lateral sides of the blade. The knife handle has handle scales attached to opposite sides of the knife blade. Each of a pair of detent elements are positioned intermediate the handle scales and knife blade on both sides of the blade, and positioned such that the detent elements will mate with the indentations. Each of a pair of spring-loaded sliding detent release shafts are mounted within the handle scales and have a tapered interior side configured to wedge between the detent element and a detent housing cover to temporarily lock the detent elements in place within the indentations.
US10981278B2 Robot system
A robot system including at least one robot arm and a control unit which is designed such that it can pre-set at least one pre-defined operation carried out by the robot system. The robot system also includes a display device and at least one input device applied to the robot arm, which is designed such that the sequence of operations of the robot system is set and/or the pre-defined operations of the robot system is parameterized by means of the input device, and which is also designed such that it allows the user to control, on a graphic user interface, represented by the control unit on the display device, the setting of the pre-defined operations of the robot system, the setting of the sequence of operations and/or the parameterization of the pre-defined operations for the robot system.
US10981273B2 Action teaching method for robotic arm and gesture teaching device
An action teaching method is provided for teaching a robotic arm of a robotic arm system through a gesture teaching device. In a step (a), a touch condition of a user's finger is sensed by the touch sensing unit. In a step (b), a sensing result of the touch sensing unit is transmitted to an identification unit, so that a touch information is identified by the identification unit. In a step (c), the touch information is transmitted to a teaching unit, so that the teaching unit actuates a corresponding operation of the robotic arm system according to the touch information. In a step (d), an operating result of the robotic arm system is shown on a display unit, so that the user judges whether the operating result of the robotic arm system is successful through the display unit.
US10981270B1 Operating multiple testing robots based on robot instructions and/or environmental parameters received in a request
Methods and apparatus related to receiving a request that includes robot instructions and/or environmental parameters, operating each of a plurality of robots based on the robot instructions and/or in an environment configured based on the environmental parameters, and storing data generated by the robots during the operating. In some implementations, at least part of the stored data that is generated by the robots is provided in response to the request and/or additional data that is generated based on the stored data is provided in response to the request.
US10981269B2 Ancillary handle and surgical instrumentation set comprising such an ancillary handle
A ancillary handle includes: a gripping part of the ancillary handle, a receiving part having an elongate seat for the shank, and a locking device for locking the shank and fixing the surgical instrument to the ancillary handle. A locking part engages in a groove on the outer surface of the shank. The locking part translates between: iii) a locking configuration, in which the locking part engages in the groove and blocks the surgical instrument, and iv) an unlocking configuration, in which the locking part frees the shank. The locking device includes an actuation part for moving the locking part between the locking and unlocking configurations.
US10981268B2 Multiple tool with integrated case
A multiple tool with an integrated case is described. The multiple tool includes a tool assembly that includes a first pivot on which are articulated a plurality of implements, each implement rotatable from an inactive position of minimum encumbrance to at least a working position, and a carry case for housing the tool assembly. The carry case includes at least a grip portion for manually holding the tool assembly with at least one of the implements in a working position.
US10981266B2 Air duster structure and driving tool
An air duster structure that is configured to jet compressed air out of a nozzle, includes a flow amount adjustment mechanism which is configured to adjust an amount of air jetted out of the nozzle. The flow amount adjustment mechanism includes: a pipe line for circulating air; a valve member disposed inside the pipe line and being movable; and a throttle portion configured to gradually change an area of a flow channel in which air circulates, with a movement of the valve member, to control a flow amount of the air in the pipe line. The throttle portion is structured so as to increase the area of the flow channel at an accelerated rate when the valve member moves in a direction that opens the pipe line.
US10981260B2 Abrasive product and a method for manufacturing such
An abrasive product having an abrasive surface, a belt of an abrasive product, a roll of an abrasive product and a method for manufacturing an abrasive product. An abrasive product includes a backing and an abrasive surface. The abrasive surface includes at least a first abrasive area and a second abrasive area, wherein abrasive properties of the first abrasive area are different from abrasive properties of the second abrasive area.
US10981259B2 Waterjet systems and methods
A waterjet system is provided, including a pump configured to pump fluid, an electric motor configured to drive the pump; a hopper configured to store abrasive, a mixing chamber configured to mix abrasive from the hopper and the fluid from the pump to produce a slurry, where the fluid entering the mixing chamber is at a pressure between 2000 psi and 8000 psi, a cutting bed configured to receive a workpiece to be cut, and a cutting head, including an outlet nozzle, in downstream fluid communication from the mixing chamber, the cutting head configured to expel the slurry through the outlet nozzle as a high-velocity jet into the cutting bed.
US10981258B2 Adjustable stroke mechanism for random orbital machine
An adjustable stroke mechanism for a random orbital machine including a housing having a wall enclosing a cavity, an adjuster ring surrounding the housing and having a first set of gear teeth along a first portion of an inner surface, and a second set of gear teeth along a second portion of the inner surface, a counterweight having gear teeth on an exterior surface disposed within the housing, and a bearing carriage having gear teeth disposed within the housing. At least one counterweight gear that meshes with the gear teeth of the counterweight and the first set of gear teeth of the adjuster ring, and at least one bearing carriage gear that meshes with the gear teeth of the bearing carriage and the second set of gear teeth of the adjuster ring, so that movement of the adjuster ring causes movement of both the counterweight and the bearing carriage.
US10981257B2 Optical fiber polisher with ramping features
An optical fiber polisher includes a polishing mechanism, a platen, and a memory for storing operational parameters entered by a user. The optical fiber polisher includes a processor to control a pressure applied by the polishing mechanism and a rotational speed of the platen, including causing a ramping down of at least one of the pressure and the rotational speed based on the operational parameters.
US10981254B2 Ni-based alloy core wire for covered electrode, covered electrode, and method of manufacturing covered electrode
A Ni-based alloy core wire for a covered electrode according to an aspect of the invention includes, as a chemical composition, by mass %: C: 0.0100% to 0.0800%; Si: 0.010% to 0.800%; Mn: 0.010% to 1.800%; Mo: 15.0% to 28.0%; W: 2.5% to 8.0%; Cu: 0.10% to 1.20%; Ta: 0.002% to 0.120%; Ni: 65.0% to 82.3%; and a remainder: impurities with other optional selective elements; in which a value X is 0.010% to 0.160%.
US10981252B2 Closure device for chamber housing laser unit for cutting sheet metal
A closure device for a chamber housing a laser units for cutting a sheet metal strip includes, in proximity of an exit slit of the strip to be machined, a bar arranged transversely to the axis of advancement of the strip, and having, at the lower edges of the major side surfaces, longitudinal edges of a U-folded plate bound thereto. The plate has a plurality of transverse slots ending before its edges. An actuator provided for a vertical movement of the bar.
US10981249B2 Method for producing electrode sheet with tab and apparatus therefor
Provided is an epoch-making method in which an original sheet is continuously fed, and a rectangular electrode sheet with a tab can be cut out from the original sheet with a normal laser beam during the continuous feeding.The original sheet 1 is continuously moved. An ear portion 1b is separated from an electrode portion 1a with a first laser beam L1 in an ear portion separating region provided in the middle of movement of the original sheet 1, is taken up at a position where the ear portion 1b is separated, in a direction separated from a running direction of the electrode portion 1a, and the laser beam L1 is moved in the ear portion separating step to cut out a tab 5 connected to the electrode portion 1a, from the ear portion 1b. Thereafter, in the next cutting region, while tension T in the running direction of the electrode portion 1a is applied to a cut portion of the electrode portion 1a, the electrode portion 1a is cut at a predetermined interval with a second laser beam L2 to continuously form an electrode sheet 3 with the tab 5. Thereafter, the electrode sheet 3 with the tab 5 and the separated ear portion 1b are collected.
US10981248B2 Hybrid welding apparatuses, systems and methods for spatially offset components
Hybrid welding methods include directing a laser beam from a laser onto a first component that is vertically offset from a second component, and, directing a weld arc from an arc welder onto a weld joint between the first component and the second component to weld the first and second components together.
US10981247B2 Device for additive manufacturing of a turbomachinery part by direct metal deposition onto a substrate
A device for the additive manufacturing of a turbomachinery part by direct metal deposition onto a substrate comprising: a source of metallic material; a source of energy configured to produce molten metal from the metallic material produced from the source of metallic material; a substrate; a mold arranged on the substrate and equipped with at least one opening, in order to allow a localized deposition of molten metal onto the substrate, the mold comprising a magnetic material; and a substrate support arranged under the substrate, the support being configured to generate an electromagnetic force allowing the mold to be drawn towards the substrate.
US10981245B2 Apparatus for ultrasonic welding of polymers and polymeric composites
Apparatus are provided for ultrasonic welding of a workpiece of one or more components. The apparatus includes a horn configured to contact the workpiece and to transmit energy to the workpiece. The horn includes a shank and a tip disposed at an end of the shank facing the workpiece. The tip has a face that has a tip radius forming a curved surface at the face. A knurl is formed on the face across the curved surface.
US10981244B2 Resistance welding electrode
A welding electrode includes a weld face that has a convex base weld face surface and a plurality of ringed ridges that are radially spaced apart on the base weld face surface and surround a central weld face axis. The plurality of ringed ridges including an innermost ringed ridge and an outermost ringed ridge. The innermost ringed ridge is located closest to the central weld face axis and rises above a central portion of the base weld face surface, and the outermost ringed ridge is located farthest from the central weld face axis and rises above an outer peripheral portion of the base weld face surface. At least one of the plurality of ringed ridges is a discontinuous ringed ridge.
US10981243B2 Multi-step direct welding of an aluminum-based workpiece to a steel workpiece
A workpiece stack-up that includes at least a steel workpiece and an aluminum-based workpiece can be resistance spot welded by employing a multi-stage spot welding method in which the passage of electrical current is controlled to perform multiple stages of weld joint development.
US10981242B2 Collar assembly for securing consumables of an arc welding apparatus
An arc welding apparatus includes a conductor tube assembly that has a collar assembly with a collar body that is biased by a spring. A consumable assembly is mechanically secured to the conductor tube and displaces the collar body and the collar body imparts a biasing force against the consumable assembly pretensioning the consumable assembly on the conductor tube assembly.
US10981241B2 Solder handling apparatus
A solder feed structure has a solder exit aperture with an elongated shape. The elongated shape can help reduce the incidence of clogging, as it has a dimension that is significantly larger than the wire diameter of solder. The solder feed structure has a bent segment leading up to the solder exit aperture. The arc of the bent segment can cause the solder wire to be in a stable position at one end of the elongated shape of the solder exit aperture instead of wobbling within the solder exit aperture.
US10981240B2 Saw tooth and insert therefor
A saw tooth for a saw including a square saw tooth body to be mounted on a holder and for receiving inserts fastened to inwardly sloping seating surfaces on the cutting end of the tooth body. The inserts are provided with cutting edges. Between seating surfaces, the cutting end of the tooth body defines recesses for receiving intermediate members fastened therein. The intermediate members are provided with cutting edges, and the intermediate members abut the adjoining inserts to form a cutting surface about the periphery of the cutting end of the saw tooth and help protect the saw tooth body from damage including washout.
US10981238B2 Actuators for power tool safety systems
Fast-acting and low-inertia actuators useable in various applications where a high force must be applied very quickly are disclosed. Power tools with detection systems configured to detect a dangerous condition between a person and a cutting tool are disclosed. In power tools, for example in a woodworking machine, a fast-acting and low-inertial actuator as disclosed herein can be used to retract a blade upon detection of a dangerous condition by a detection system. The actuator includes a charge of pressurized fluid and one or more electromagnets to selectively retain or release the pressurized fluid.
US10981236B2 Device for ensuring proper location of a cutout in a sheet of construction material
An apparatus for ensuring proper location for a cutout in a sheet of construction material, to provide for access to an electrical box, includes an electrical box locator device with a body and at least one spike. The body mounts to the front opening of the electrical box and the spike projects perpendicularly relative to the plane of the electrical box opening such that it pierces the sheet of construction material and is visible on the side of the sheet of construction material opposite the side facing the electrical box once the sheet of construction material is positioned over the opening of the electrical box so as to help in locating a cutout in the sheet of construction material for the electrical box.
US10981222B2 Casting method for active metal
A casting method of an active metal includes, in an induction melting furnace using a water-cooled crucible, tapping a molten metal into a mold from a tapping hole provided at a bottom of the water-cooled copper crucible to cast an ingot of the active metal. In conducting the casting under a casting condition in which the ingot has a diameter (D) of 10 mm or more and a ratio (H/D) of an ingot height H to the ingot diameter D of 1.5 or more and a weight of the molten metal tapped in the casting is 200 kg or less, a temperature of the molten metal in the casting is set to be higher than the melting point of the active metal and a casting velocity V (mm/sec) is controlled to satisfy V≤0.1H in relation with the ingot height H by adjusting an opening diameter of the tapping hole.
US10981221B2 Method and assembly for forming components using a jacketed core
A mold assembly for use in forming a component having an outer wall of a predetermined thickness includes a mold and a jacketed core. The jacketed core includes a jacket that includes a first jacket outer wall coupled against an interior wall of the mold, a second jacket outer wall positioned interiorly from the first jacket outer wall, and at least one jacketed cavity defined therebetween. The at least one jacketed cavity is configured to receive a molten component material therein. The jacketed core also includes a core positioned interiorly from the second jacket outer wall. The core includes a perimeter coupled against the second jacket outer wall. The jacket separates the perimeter from the interior wall by the predetermined thickness, such that the outer wall is formable between the perimeter and the interior wall.
US10981220B2 Hybrid part over-molding process and assembly
A method of over-molding a hybrid sub-assembly onto a base structure includes providing a mold for an over-molding process. The mold may comprise a lower mold tool, an upper mold tool, and a tube locator positioned on one of the upper mold tool or lower mold tool. A base structure formed of a first material is located into the tube locator. A mandrel tool is inserted into an opening in the base structure. The upper and lower mold tools are closed and clamped shut. A second material, such as a lighter weight or lower density material is heated to at least a semi-solid or slurry state. The semi-solid or slurry is injected into the mold to form a molded sub-assembly that is mechanically bonded to the base structure.
US10981219B1 Casting mold and manufacturing method of cast part
The casting mold is provided with: the molding wall portion forming the internal space; the supporting portion supports the heater to the molding wall portion; and the filling port allows the molten metal to flow into the internal space. The heater has: the end portion (the fixed portion) supported by supporting portion; and the extending portion extended from the end portion. The internal space has: the supporting region accommodating the end portion; and the extending region accommodating the extending portion. The filling ports respectively open to the portions of the molding wall portion facing the supporting regions.
US10981200B2 Processing method and device for small parts
The processing device for small parts is equipped with ultrasound probes for decreasing the number of particles and with microwave generators for drying the small parts.
US10981197B2 Injection molded screening apparatuses and methods
Screening members, screening assemblies, methods for fabricating screening members and assemblies and methods for screening materials are provided for vibratory screening machines that incorporate the use of injection molded materials. Use of injection molded screen elements provide, inter alia, for: varying screening surface configurations; fast and relatively simple screen assembly fabrication; and a combination of outstanding screen assembly mechanical and electrical properties, including toughness, wear and chemical resistance. Embodiments of the present invention use a thermoplastic injection molded material.
US10981194B2 Method for manufacturing and painting characters press formed on license plates and tubular thermal transfer film for carrying out said method
The present invention relates to a method for manufacturing and painting characters press formed on license plates and to a tubular thermal-transfer film for carrying out said method which comprises: a step of press forming identifying characters (2) on an aluminum plate (1) with a reflective film (3), including a perimetral edge (4) or not, by means of using a hand- or motor-operated press forming machine or device; and a step of thermal stamping for painting the press formed characters (2) by means of thermal-transfer ink impregnated in a thermal-transfer film with a thermal stamping machine (6) which in turn comprises: introducing the plate (1) in a tubular thermal-transfer film (5), closing the open end or ends (5d) of said tubular film (5), introducing the assembly (5, 1) in the thermal stamping machine (6), and removing the finished plate (1) from inside the tubular film (5).
US10981191B2 Metal printed constructions
There is disclosed a print construction comprising: (a) a printing substrate having an image-receiving surface; (b) a receptive layer, at least partially covering said image-receiving surface, and having a particle reception surface distally disposed to said image-receiving surface, said receptive layer optionally having a thickness of at least 1000 nanometer (nm); and (c) a plurality of individual particles adhered to said particle reception surface, and forming a monolayer thereon, the features of which are described herein.
US10981188B2 Apparatuses for removing residue from a nozzle
An apparatus for removing a residue of a substance, extrudable through a nozzle of an automated end-effector, from an exterior of the nozzle is disclosed. The apparatus comprises a dispenser. The dispenser comprises a platform to support at least one cleaning pad. The dispenser further comprises a cage to maintain at least the one cleaning pad on the platform. The platform is movable relative to the cage. The apparatus also comprises a constricting device to circumferentially squeeze one of at least the one cleaning pad, adhesively picked up from the platform by the nozzle, around the nozzle once the nozzle is inserted into the constricting device. The apparatus additionally comprises a disposal receptacle to collect the one of at least the one cleaning pad, released from the constricting device.
US10981182B2 Centrifuge with cooling system in centrifuge housing
A centrifuge (10) having a centrifuge housing, a safety vessel (14) arranged in the centrifuge housing, an interior space (16) at least partially bounded by the safety vessel (14), a rotor arranged in the interior space (16), and a cooling system, arranged in the centrifuge housing, for cooling the interior space (16), having a compressor (22), a condenser (24) and an evaporator (26), which are connected together via lines. The invention is distinguished by the fact that the cooling system has a primary circuit (52) with primary line (29) and a secondary circuit (62) with secondary line (34), wherein the primary circuit (52) comprises the compressor (22), the condenser (24) and the evaporator (26), which is part of a heat exchanger (30), and wherein the secondary circuit (62) flows through the heat exchanger (30), cools the safety vessel (14) and is provided with a pump (32).
US10981181B2 Mineral beneficiation utilizing engineered materials for mineral separation and coarse particle recovery
A selective recirculation circuit has a loading stage, a stripping stage and a filtering stage for use in processing a feed stream or slurry containing mineral particles. The stripping stage forms a first loop with the loading stage, and a second loop with the filtering stage. The loading stage has a loading mixer and a loading washing screen. The stripping stage has a stripping mixer and a stripping washing screen. The loading mixer receives the slurry and causes barren media in the circuit to contact with the slurry so that the mineral particles in the slurry are loaded onto the barren media. The media is directed to the stripping stage where the mineral particles are removed from the media. The barren media is recycled to the loading stage. The stripping solution recovered from the filtering stage is returned to the stripping stage and the mineral particles are discharged as concentrate.
US10981179B2 Feeding arrangement for a granulator and granulator comprising such a feeding arrangement
An accumulation device that is operable in a feeding arrangement of a granulator, for accumulating flat material to be granulated, includes a first guiding device and a second guiding device. The accumulation device further includes a rotational shaft arranged to connect the accumulation device to the feeding arrangement. The first and the second guiding device are fixedly arranged in relation to each other so that when the accumulation device is rotated around its rotational shaft, the first guiding device as well as the second guiding device is rotated around the rotational shaft. A feeding arrangement and a granulator including such an accumulator device are also provided.
US10981178B2 Self-cleaning garbage disposal system, and method of operation
A self-cleaning garbage disposal system is provided including a container having a neck portion leading to a container opening and a flow switch valve for connecting the container to a dishwasher drain hose. The flow switch valve is switchable to an open position to allow dishwasher water to be fed to the container from the dishwasher drain hose and to a closed position to not allow dishwasher water to be fed to the container from the dishwasher drain hose based on a rotational position. The garbage disposal system can include a garbage disposal cap to be rotationally inserted into the container opening, and the flow switch valve operation can respond to the rotational position of the garbage disposal cap. Sensors can be provided on the garbage disposal cap and the neck portion of the container to detect the rotational position of the garbage disposal cap.
US10981173B1 Endothermic syringe sleeve
The endothermic syringe sleeve is an insulating storage structure. The endothermic syringe sleeve is configured to store a burette that contains an arterial blood samples. The endothermic syringe sleeve is configured to cool the arterial blood sample. The endothermic syringe sleeve is configured to store the arterial blood sample in the cooled state. The endothermic syringe sleeve comprises an endothermic sleeve and the burette. The endothermic sleeve forms a cooled environment within which the burette is stored.
US10981170B2 Oligonucleotide encoded chemical libraries
This application provides a bead with a covalently attached chemical compound and a covalently attached DNA barcode and methods for using such beads. The bead has many substantially identical copies of the chemical compound and many substantially identical copies of the DNA barcode. The compound consists of one or more chemical monomers, where the DNA barcode takes the form of barcode modules, where each module corresponds to and allows identification of a corresponding chemical monomer. The nucleic acid barcode can have a concatenated structure or an orthogonal structure. Provided are method for sequencing the bead-bound nucleic acid barcode, for cleaving the compound from the bead, and for assessing biological activity of the released compound.
US10981169B2 Micro-vials
A micro-vial for handling micro-volume of sample fluids. The interior wall defined in the vial has a cylindrical sample section, a wider cylindrical alignment section, a tapered or conical guide section, and a relatively large cylindrical body section, arranged in sequence in that order along the center axis of the vial. The sample section holds a small volume of a sample fluid and receives the tip end of a capillary tube. The alignment section has a larger diameter than the sample section, receiving a cylindrical support that coaxially supports the relatively fragile capillary tube. The tip of the capillary tube dips into the micro-volume of sample fluid held in the sample section. The conical section guides the capillary tube and the support tube into the alignment section and the tip of the capillary tube into the sample section.
US10981168B2 AM-EWOD array element circuitry with integrated sensing and method of sensing droplet merging
A method of operating an active matrix electro-wetting on dielectric (AM-EWOD) device provides for enhanced mutual capacitance sensing using integrated impedance sensing circuitry. Array element circuitry of each array element includes actuation circuitry configured to apply actuation voltages to the array element electrode for actuating the array element, and impedance sensor circuitry integrated into the array element circuitry and configured to sense impedance at the array element electrode. The method of operating includes the steps of: perturbing a voltage applied to the array element electrode of a first array element; coupling the voltage perturbation to the array element electrode of a second array element different from the first array element; and measuring the output current from the sensor readout transistor of the second array element for sensing in response to the voltage perturbation. The method may be performed by an AM-EWOD control system executing program code stored on a non-transitory computer readable medium.
US10981163B2 Method and system for hydrophobic coating of microfluidic chips
This disclosure concerns a method of providing a hydrophobic coating on a microfluidic chip that promotes the discrete flow of at least one liquid. It includes applying the hydrophobic coating onto an area of the microfluidic chip. The disclosure further includes a microfluidic chip that provides discrete flow of at least one liquid.
US10981157B2 Tri-(adamantyl)phosphines and applications thereof
In one aspect, phosphine compounds comprising three adamantyl moieties (PAd3) and associated synthetic routes are described herein. Each adamantyl moiety may be the same or different. For example, each adamantyl moiety (Ad) attached to the phosphorus atom can be independently selected from the group consisting of adamantane, diamantane, triamantane and derivatives thereof. Transition metal complexes comprising PAd3 ligands are also provided for catalytic synthesis including catalytic cross-coupling reactions.
US10981146B2 Super-absorbent polymer and method for preparing same
The present invention relates to a super-absorbent polymer having excellent properties, both centrifugal retention capacity (CRC) and absorption under pressure (AUP) having been improved by introducing a surface crosslinked layer crosslinked by surface-modified inorganic particles, and to a method for preparing the same. The super-absorbent polymer comprises: a base resin powder containing a crosslinked polymer of water-soluble ethylene-based unsaturated monomers having an at least partially neutralized acidic group; and a surface crosslinked layer formed on the base resin powder, wherein inorganic particles may be chemically bound to the crosslinked polymer contained in the surface crosslinked layer, via an oxygen-containing bond or a nitrogen-containing bond.
US10981142B2 Hydroprocessing reactor to lower pressure drop and extend catalyst life
A reactor for accommodating high contaminant feedstocks includes a reactor vessel having an inlet for introducing a feedstock containing contaminants into an interior of the reactor vessel. A basket is located within the reactor vessel interior and contains a particulate material for removing contaminants from the feedstock to form a purified feedstock that is discharged to a purified feedstock outlet. A catalyst is located within the reactor vessel and in fluid communication with the purified feedstock outlet of the basket for contacting the purified feedstock to form a desired product.
US10981140B2 Catalytic reactor
A catalytic reactor includes: a reaction-side flow channel in which a reaction fluid flows; a structured catalyst removably located in the reaction-side flow channel; and a protrusion formed in the structured catalyst or an inner surface of the reaction-side flow channel, having a height forming a clearance between the structured catalyst and the inner surface of the reaction-side flow channel.
US10981138B2 Electrochemical reactor using ion on/off surface switch
An electrochemical reactor includes an ion ON/OFF surface switch operating as an ionic conductor, which includes a pair of electrodes, an electrolyte aqueous solution present between the pair of electrodes, a water-repellent porous fluororesin membrane disposed such that at least one surface thereof is in contact with the electrolyte aqueous solution and including a plurality of pores communicating with each other and a pressing equipment configured to pressurize the electrolyte aqueous solution. As such, electrolysis, a secondary battery and a capacitor, which uses the water-repellent porous fluororesin membrane as an ion ON/OFF surface switch, can be provided.
US10981135B2 Treating catalytically oxidized nanofibrillar cellulose hydrogel
The invention relates to a method for treating a nanofibrillar cellulose hydrogel, wherein the method comprises the steps of: providing a nanofibrillar cellulose hydrogel, wherein the nanofibrillar cellulose is oxidized nanofibrillar cellulose, wherein the oxidation has been carried out through N-oxyl mediated catalytic oxidation of cellulose-based raw material, and has at most 50 μmol of aldehyde groups per gram of dry nanofibrillar cellulose; and subjecting the nanofibrillar cellulose hydrogel to a heat treatment.
US10981134B2 Quenching system
A quenching system for a plant, operating a cracking furnace, works with liquid as well as gaseous starting materials. The quenching system includes a primary heat exchanger (PQE 10) and a secondary heat exchanger (SQE 11) and a tertiary heat exchanger. A TLX-D exchanger (TLX-D 26) is arranged and configured as the tertiary heat exchanger for dual operation. The TLX-D (26) is connected in series via a TLX-D gas feed line (24) to the SQE 11. The TLX-D (26) is connected to a steam drum (59), which is connected to a feed water line (49), via a TLX-D feed water drain line (34) and a TLX-D riser (46) and a TLX-D downcomer (38). The SQE 11 is connected to the steam drum (59), which is connected to the feed water line (49), via a TLX downcomer (52) and a TLX-riser (57).
US10981125B2 Method for compounding and applying adhesives
The invention relates to continuous methods for compounding and applying adhesives, characterized in that (i) a base component of the adhesive is mixed continuously with at least one aggregate so as to produce a compounded adhesive; and (ii) the adhesive compounded in this manner is applied to a substrate. The invention also relates to such methods where a device as described here is used to carry out the method.
US10981122B2 Monolayer, composite, gas separation material, filter, gas separation device and method for manufacturing composite
A monolayer membrane containing gelling polymer particles having at least one of a basic functional group and an acidic functional group, and having a thickness of less than 5 μm. A composite having a porous carrier and gelling polymer particles having at least any one of a basic functional group and an acidic functional group and filling up the surface pores of the porous carrier. The invention can provide a novel material capable of efficiently separating an acid gas from a mixed gas.
US10981120B2 Selective interfacial mitigation of graphene defects
A method for the repair of defects in a graphene or other two-dimensional material through interfacial polymerization.
US10981117B2 Blended potting resins and use thereof
A thermoplastic blended potting resin, a blended resin potted membrane, a membrane separation module, a fluid separation device, a method of making and a method of using the membrane separation module and the fluid separation device are described herein. The blended thermoplastic potting resin comprises at least one polar membrane having two end regions and a middle region; and a blended resin comprising a non-polar thermoplastic polymer and a polar thermoplastic polymer; wherein at least one of the two ends regions is coated with the blended potting resin to form a fluid-tight seal between the end regions and the open middle region, and wherein the polar thermoplastic polymer is 1% or greater by weight of blended resin.
US10981116B2 Process and system for treating waste water and generating power
A process for treating waste water, including the steps of extracting by forward osmosis treated water from a wastewater feed stream and transferring it to a saline draw stream, and extracting from the saline draw stream treated water by a reverse osmosis process.
US10981111B2 Carbon dioxide conversion reactor, series reactor for converting and capturing carbon dioxide including the same, and process of converting and capturing carbon dioxide using the same
The present invention relates to a carbon dioxide conversion reactor and more particularly, to a carbon dioxide conversion reactor capable of converting carbon dioxide contained in flue gas into an aqueous bicarbonate solution that may be used in many applications; and at the same time, preventing back pressure from increasing due to supplied flue gas by allowing a conversion process to rapidly proceed, thereby significantly reducing the level of carbon dioxide contained in flue gas with high efficiency and high conversion speed, a series reactor for converting and capturing carbon dioxide including the carbon dioxide conversion reactor, and a process of converting and capturing carbon dioxide using the carbon dioxide conversion reactor.
US10981110B2 Adsorbent materials, apparatus, and methods for removal of hydrogen sulfide from gases
An adsorbent composition, adsorbent apparatus, and gas purification process using the absorbent composition are provided for the removal of hydrogen sulfide from a gas containing at least hydrogen sulfide as an impurity. The adsorbent composition includes a combination of at least one carbon material, at least one clay material, and at least one metal oxide. In particular, the combination of carbon material(s), clay material(s) and metal oxide(s) provide for effective removal of hydrogen sulfide from a gas at a reduced cost.
US10981106B2 Regenerable battery for electricity generation from gas separation process or captured carbon dioxide
The invention pertains to processes for separating gases, acid gas, hydrocarbons, air gases, or combinations thereof. The processes may employ using a liquid phase cloud point with or without subsequent liquid-liquid separation. In some embodiments membranes can be employed with reverse osmosis to regenerate a solvent and/or an antisolvent. In some embodiments thermal switching phase changes may be employed during absorption or desorption to facilitate separation.
US10981105B2 Carbon dioxide capturing system and operation method of carbon dioxide capturing system
A carbon dioxide capturing system according to an embodiment is provided with a reboiler which heats an absorption liquid in a regeneration tower with a heated steam, and condenses the heated steam to generate a downstream side condensed water. The heated steam is supplied to the reboiler by an upstream side line. The downstream side condensed water is discharged from the reboiler by a downstream side line. A branched line branches from the upstream side line. The heated steam supplied to the branched line is cooled and condensed by an upstream side cooler, and an upstream side condensed water is generated. A physical quantity of an absorption liquid component in the upstream side condensed water and a physical quantity of an absorption liquid component in the downstream side condensed water are measured by a physical quantity measurement device.
US10981101B2 System for scrubbing or filtering a gas stream
A gas stream scrubbing and/or filtration system using a pressurized working fluid includes a working chamber having an inlet and an outlet for the gas stream, and a first opening for entering the working fluid; a first feeding line of the working fluid having a spraying nozzle for spraying the working fluid inside the working chamber; and a mounting system of the nozzle on the working chamber at the first opening. In particular, the mounting system is configured to enable the nozzle to spray the working fluid inside the working chamber, passing through the first opening. The mounting system is further configured to provide access to the nozzle from outside of the working chamber, so as to allow an operator to easily perform maintenance, replacement and/or adjustments thereof.
US10981099B2 Expandable air filters
An expandable air filter. The air filter including a filter media assembly, an outer frame assembly, and at least one support member. The filter media assembly defines opposing, first and second major faces and a perimeter. The outer frame assembly is arranged about the perimeter. The support member is connected to the outer frame assembly and extends across the first major face. Further, the support member defines a line of separation at which the support member can be separated into first and second segment to permit expansion of the air filter. The filter media can form a plurality of pleats, with at least one pleat being free of bonding to the outer frame assembly. The unbonded pleat experiences expansion as the air filter transitions to an expanded state. The air filter can be configured for expansion in one or both of a length and width direction.
US10981098B2 Air filter element, in particular for gas filtration
An air filter element has a filter medium body that has a wall to be flowed through by a fluid to be purified in a radial direction relative to a longitudinal axis of the filter medium body. The filter medium body has a first end face and an oppositely positioned second end face. The filter medium body has an elongate cross section shape with two oppositely positioned narrow sides and two oppositely positioned long sides connecting the two narrow sides. A cross section surface of the filter medium body tapers from the first end face toward the second end face. The two long sides each have an inwardly oriented radial constriction in a region of the narrow second end face, wherein, in a region of the first end face, the two long sides are formed without or at least approximately without the inwardly oriented radial constriction, respectively.
US10981097B2 High-temperature dust removal and filtering apparatus, high-temperature dust removal and filtering system, and continuous dust removal and filtering method
A high-temperature dust removal and filtering apparatus, comprising a set of high-temperature dust removal and filtering devices and a pre-heating apparatus and regeneration apparatus provided for the high-temperature dust removal and filtering devices; a high-temperature dust removal and filtering system, comprising two or more sets of high-temperature dust removal and filtering devices, and a pre-heating apparatus and regeneration apparatus provided for the high-temperature dust removal and filtering devices; a continuous dust removal and filtering method consisting of two or more sets of high-temperature dust removal and filtering devices and a pre-heating apparatus and regeneration apparatus provided for the high-temperature dust removal and filtering devices. Said method is implemented with a high-temperature dust removal and filtering system capable of switching. The high-temperature dust removal and filtering system always keeps one or more sets of high-temperature dust removal and filtering devices in a normal filtering state.
US10981095B2 Nonwoven fabric and air filter including same
A nonwoven fabric according to the present invention is formed so that constituent fibers of the nonwoven fabric have an average fiber diameter of less than 1 μm and the number of fibers having fiber diameters ranging from 2 times up to 10 times the average fiber diameter of the constituent fibers is in a range of 2 to 20% of a total number of the constituent fibers. When the nonwoven fabric according to the present invention is used as a filter layer constituting an air filter, for example, it is possible to achieve high collection efficiency while reducing clogging (packing) between fibers to solve problems that may occur in using the conventional nanofiber nonwoven fabric (such as an increase in pressure loss and a decrease in service life).
US10981089B2 Underdrain assembly and method of manufacturing same
An underdrain apparatus and a method for manufacturing such apparatus are provided. The underdrain apparatus can be extruded in long sections as a unitary part. The underdrain apparatus may be extruded in various sizes, shapes, and materials. Further, the underdrain apparatus may include a passageway for transporting water to and from the filter media and/or air to the filter media. In some embodiments, apertures are formed in the underdrain apparatus during an extrusion process to provide a path between the passageway and the filter media.
US10981088B2 Sand collection and concentration tank
A collection and concentration system including a separation tank having a plurality of distribution arms configured to separate and recover oil, water, and sediment or sand from an inflowing mixture of the same. The distribution arms are connected to and in fluid communication with a downcomer section of a center column that is vertically arranged in the separation tank. The distribution arms extend radially toward a sidewall of the tank and include tangential discharge nozzles that are tangentially directed toward the sidewall. Inflowing mixture directed tangentially against the sidewall is directed in a downward, helical manner that assists in the separation and recovery of oil, water, and sediment from the inflowing mixture.
US10981085B2 Continuous extraction of natural products from plants apparatus and methods
A reaction assembly separating plant material from water includes a first annular filter element defining an axis. The first annular filter element is defined by an outer annular coil of flat wire and an optional second filter element is defined by an inner annular coil of flat wire, being generally helical in the axial direction. A cylindrically or frustoconical filter membrane is concentrically disposed between the first and second annular filter element. The filter membrane is porous having aperture size of less than a nano-particulate size of the plant material, but greater than a nano-particulate size of the water molecule. The second annular filter includes adjustable porosity for selectively preventing particles from reaching the filter membrane and selectively cleaning the membrane by reversed flow of water through the membrane. The assembly generates radial and distal flows and differential pressure forces, for use in high throughput industrial, agricultural and municipal facilities.
US10981082B2 Humidification-dehumidification desalination systems and methods
Embodiments described herein generally relate to humidification-dehumidification desalination systems, including apparatuses that include a vessel comprising a humidification region (e.g., a bubble column humidification region) and a dehumidification region (e.g., a bubble column dehumidification region), mobile humidification-dehumidification (HDH) desalination systems (e.g., systems having a relatively low height and/or a relatively small footprint), and associated systems and methods. Certain embodiments generally relate to methods of operating, controlling, and/or cleaning desalination systems comprising a plurality of desalination units (e.g., HDH desalination units).
US10981079B1 Fog machine
A fog machine supplies air to a fog liquid reservoir to force the fog liquid into a heater, wherein the fog liquid vaporizes to produce fog. The fog liquid supply to the heater can be halted, and the air supply can then be used to purge the heater of residual fog liquid. Within the heater, the fog liquid travels from outer passages further from the heating element(s) to inner passages closer to the heating element(s), whereby the fog liquid is preheated prior to vaporization, resulting in a higher degree of vaporization and “drier” fog with finer vapor particles. The fog machine may draw fog liquid from an “offboard” fog liquid reservoir, such as an off-the-shelf jug of liquid, and is preferably remote-controllable via a user's smartphone.
US10981078B2 Methods for a stage performance
Disclosed are methods that create the perception for an audience that an actor is being transported from one location to another during a stage performance. Also disclosed are methods for entrance onto/exit from a stage platform by an actor, or entrance onto/exit from a stage backdrop by a precision image that represents an actor. The disclosed methods involve interaction of an actor with an object/prop or image of an object/prop, and/or involve interaction of an image of an actor with an object/prop or image of an object/prop during a stage performance.
US10981076B2 Circuit arrangement for a model car racing track
A circuit arrangement for a model car racing track, having at least two tracks for model cars, wherein a positive busbar and a negative busbar are in each case assigned to each track, and a first driving speed controller is connected between a positive supply terminal and the positive busbar of the first track and a second driving speed controller is connected between a negative supply terminal and the negative busbar of the second track.
US10981075B2 Action figure
The disclosure herein relates to dolls and action figures that are capable of lifelike movement via a manual controller. In some embodiments, only the movement of the arms or legs is manually controlled. In another embodiment, the movement of both the arms and legs is manually controlled. In some embodiments, the actuator gearing system includes a clutch to help prevent the gears from stripping. In other embodiments, the controller is removable.
US10981073B2 Localized and standalone semi-randomized character conversations
Techniques for randomized device interaction are provided. A first communication pattern is selected, with at least a degree of randomness, from a plurality of communication patterns, where each of the plurality of communication patterns specifies one or more audio profiles. A first audio profile specified in the first communication pattern is identified. A first portion of audio is extracted from a first audio file with at least a degree of randomness, and the first portion of audio is modified based on the first audio profile. Finally, the first modified portion of audio is outputted by a first device.
US10981072B1 Modular stacked motion simulation system
A motion simulator system includes a display screen and multiple rider motion apparatuses. Each rider motion apparatus supports at least one rider accommodation and is positionable in a ride position facing the display screen. The motion simulator system includes multiple motion bays with an open front end facing the display screen. Each motion bay encloses at least one of the rider motion apparatuses. Multiple motion bays can be stacked facing the same display screen. A subset of the rider motion apparatuses may be activated, even when one or more rider motion apparatuses are in an inactive state. A visual display can be provided on the display screen that is synchronized with motion of the active rider motion apparatuses.
US10981071B1 Modular stacked motion simulation system
A motion platform apparatus has a fixed base and a track that extends in a forward-rearward direction. A motion platform is movably mounted on the track and extends between a platform front end and a platform rear end in the forward-rearward direction. A seating assembly is mounted on the motion platform. The seating assembly has at least one user seat that includes a seat base. The motion platform is movable along the track to position the seating assembly in a load position and in an in-use position. The load position of the seating assembly is rearward of the in-use position. The seating assembly is mounted to the motion platform underneath the seat base. The front end of each seat base may be positioned forward of the platform front end. The seating assembly can be tilted as it moves between the load position and the in-use position.
US10981070B2 Position-based decision to provide service
A service may be provided to a set of people when the people satisfy a proximity criterion. In one example, that set of people comprises users of a particular application and/or registrants with a particular system. A location monitor may determine people's location based on position data received from those people's devices (which may be obtained pursuant to appropriate permission in order to respect the device owners' interest in privacy). When the location monitor determines, based on people's positions, that a proximity criterion has been satisfied, the location monitor may cause a service to be provided that would not otherwise have been provided if the proximity criterion had not been satisfied. By providing additional service when a proximity criterion is satisfied, a reward in the virtual world is used to encourage people to gather in the physical world.
US10981068B2 Information processing system, information processing apparatus, computer-readable storage medium having stored therein information processing program, and information processing method
A plurality of game apparatuses function as a master, a client, and an audience. The master and the client register each other by performing therebetween an authentication process. The authentication process is not performed between the master and the audience. The audience receives a beacon from the master and registers the master in an own apparatus while the audience is not registered in the master. The master and the client execute a predetermined program, exchanging data by communicating with each other. The audience receives the data exchanged between the master and the client, and executes the predetermined program using the received data, thereby watches a game which is progressed between the master and the client, as a spectator.
US10981067B2 Game processing system, method of processing game, and storage medium storing program for processing game
A game processing system for processing a game having a first mode and a second mode according to an aspect includes one or more computer processors. The one or more computer processors are configured to provide, in the first mode, an interaction with a virtual character in accordance with first detection information obtained by an information processing device not mounted on a head of a player. The one or more computer processors also performs a switch process from the first mode to the second mode and provide, in the second mode after the switch process, an interaction with the virtual character in accordance with second detection information obtained by a head mounted display mounted on the head of the player.
US10981064B2 Storage medium, information-processing device, information-processing system, and information processing method
A game system provides a virtual game space in which plural players play a game. In the virtual game space, if a player object performs a first action on an item appearance area, the game system determines whether a right state of the player object is a first state or a second state. If the right state of the player object is the first state, the game system determines that an item appearance condition is satisfied. If the right state of the player object is the second state, the game system determines that the item appearance condition is not satisfied. If it is determined that the item appearance condition is satisfied, the game system causes a game item to appear in the virtual game space, and changes the right state of the player object to the second state.
US10981058B2 Method and apparatus for providing a computer implemented game
A computer implemented method comprises display of a navigable image on a display. The navigable image comprises a plurality of game objects. Game resources are associated with at least one of said game objects. A given amount of game resources are provided in a respective time period. The providing of the game resources can be speeded up if a computer game is played and an objective associated with the game achieved.
US10981054B2 Player biofeedback for dynamically controlling a video game state
Various embodiments are directed towards employing one or more physical sensors arranged on or in proximity to a video game player to obtain biofeedback measures that are then usable to dynamically modify a state of play of a video game. The sensors may be connected or even unconnected to the game player, replace, or otherwise augment traditional physical game controllers. The sensors gather various biofeedback measures and provide such measures to a biofeedback application programming interface (API). Before and/or during video game play, the video game queries the biofeedback API to request inferences about the game player's state of arousal. The response to the query is then used to modify the state of the video game play. Where the video game is a multi-player video game, biofeedback measures from other game players may also be obtained and used to further modify the state of the video game play.
US10981049B2 Board game system. method of use, and method of assembly
A board game featuring a board having a removable rotatable tower having an arm extending away from it and a hook for receiving a ring hung from a string from the arm. Players move their pieces about the board. Cards may be drawn at random intervals. The player may be required to toss the ring towards the hook located on the tower. Successfully hooking the ring to the tower may affect the outcome of the player's turn. The tower may be rotated on the board, so that each player can swing the ring, depending on outcomes from the various features of the game, including the cards, dice rolls, and space locations on the game board.
US10981042B2 Retractable cord system
This invention is directed toward a portable and easy to set up retractable cord system with means to allow athletes to move along specified routes and to form space indicators that show zone areas.
US10981040B2 Golf club head having stress-reducing features
A golf club head comprising a body and a stiffening structure is disclosed herein. The body comprises a face section, a sole section, and a crown section, and defines a hollow interior. The stiffening structure extends within the hollow interior from the crown section to the sole section to reduce stresses placed on the face section during impact with a golf ball. The stiffening structure is entirely located within 0.500 inch of a rear surface of the face section measured along a plane normal to the center of the face, and within 1 inch of the center of the face section along a horizontal axis parallel to the face section, and comprises heel and toe connectors connected to one another by a middle connector, such that the stiffening structure has an approximately X- or H- overall shape.
US10981037B2 Golf club heads and methods to manufacture golf club heads
Embodiments of golf club heads and methods to manufacture golf club heads are generally described herein. In one example, a golf club head may include a body portion having a first interior cavity and a second interior cavity. The first interior cavity may be located in a first transition region between the top portion and the front portion. The second interior cavity may be located within the body portion and in a second transition region between the bottom portion and the front portion. Other examples and embodiments may be described and claimed.
US10981036B2 Variable aquatic training aid
An aquatic training aid includes a paddle member for wearing by a swimmer, a variable diaphragm disposed within the paddle member, the variable diaphragm including a plurality of fitted blades arranged to form an aperture, and a housing peripherally framing the plurality of fitted blades. The variable diaphragm is adjustable to change the aperture from a first expanded position to a second contracted position, and hydrodynamic characteristics of the aquatic training aid when moved through water are affected by the change of the aperture. Controlling the aperture enables the swimmer to adjust the resistance provided by the aquatic training aid when it is moved through water.
US10981035B2 Portable lower limb therapy device
A portable lower limb therapy device having a support base and a pulley system. The support base includes a platform member fixably mounted on top of a slider and a heel panel positioned behind the platform member. The heel panel, which sits orthogonally relative to the platform member, is attached to the slider so as to extend from the rear end of the slider. The pulley system defines a closed force transfer system that is integrated with the support base. The pulley system employs a cord member, a support member, a cross member, and two handles and is configured to transfer force applied behind the heel panel to the platform member as well as force applied above a user's foot that is positioned on top of the platform member to the platform member.
US10981031B1 Multifunctional abdominal exercise wheel with pulling rope
A multifunctional abdominal exercise wheel with a pulling rope includes a first wheel assembly. The first wheel assembly includes a first main support, a first main wheel, a chassis cap and a first sucking disc. An end of the first main support is detachably connected to the first main wheel. The chassis cap is connected to the first main wheel by a bearing. The first sucking disc is connected to the chassis cap by a sucking disc support, and a sucking disc spring is arranged between the sucking disc support and the chassis cap. Another end of the first main support is disposed with a first beam, and the first beam is perpendicularly connected to the first main support. The multifunctional abdominal exercise wheel may have advantages of reasonable structure, multiple functions, high utilization, easy to carry, and being capable of meeting various occasions for fitness at any time.
US10981022B2 Smart respirator and method and device for calculating pollutant absorption
A smart respirator includes a main respirator-body including a first open end and a second open end. A diameter of the first open end is smaller than a diameter of the second open end. The smart respirator further includes a front respirator-body arranged at the first open end. The front respirator-body includes a filter sheet arranged inside the front respirator-body and configured to absorb pollutants in air entering the front respirator-body, an air sensor arranged inside the front respirator-body and configured to detect an air index of filtered air filtered by the filter sheet, and a flow sensor arranged inside the front respirator-body and configured to determine a total respiratory amount. The smart respirator also includes a fixation band arranged at the second open end.
US10981017B2 Photoeradication of microorganisms with pulsed purple or blue light
The present invention is directed to a system and method for photoeradication of microorganisms from a target. The target is irradiated with pulsed purple or blue light in which (a) the light pulses have a peak irradiance and a pulse duration sufficient to optically excite a photoactive molecule capable of photoeradication of the microorganisms and (b) the light pulses are separated by an off time sufficient to allow the photoactive molecule to return to a ground state creating an oxidation reaction that produces free radicals which destroy a cellular structure of the microorganisms and thereby photoeradicate all or a portion of the microorganisms. The photoactive molecule may comprise either an endogenous molecule present in the microorganisms or an exogenous molecule applied to the target.
US10981016B2 Identifiable magnetic assemblies and communications
A method of authorizing performance of transcranial magnetic stimulation on a subject using a head mount adapted to bear one or more magnetic assembly devices having unique identifiers. The method comprises connecting the one or more magnetic assembly devices to a control device, each magnetic assembly device being installed at a location on the head mount, receiving, at the control device, the identifiers of the connected magnetic assembly devices. determining whether the installed magnetic assembly devices are authorized for the treatment based on the received identifiers and treatment configuration information in a database, and energizing the connected magnetic assembly devices based on the determination of authorization.
US10981013B2 System and method to estimate region of tissue activation
A computer-implemented method for determining the volume of activation of neural tissue. In one embodiment, the method uses one or more parametric equations that define a volume of activation, wherein the parameters for the one or more parametric equations are given as a function of an input vector that includes stimulation parameters. After receiving input data that includes values for the stimulation parameters and defining the input vector using the input data, the input vector is applied to the function to obtain the parameters for the one or more parametric equations. The parametric equation is solved to obtain a calculated volume of activation.
US10981012B2 Configuration of implanted devices
According to one aspect of the present invention, there is provided an implantable medical device comprising: an implantable component, comprising an implantable memory module, configured to receive and store recipient-specific operating parameters in the implantable memory module, an external component, comprising an external memory module, configured to communicate with the implantable component to receive the recipient-specific operating parameters, and to configure the external component using the recipient-specific operating parameters, wherein the implantable medical device is configured to transfer the recipient-specific operating parameters upon operationally coupling the implantable component with the external component.
US10981007B2 Systems, methods, and devices for neuromodulation
Systems, methods, and devices for neuromodulation are described herein. For example, a method for modulating inflammatory processes of a subject is described. The method can include stimulating the subject's vagus nerve to activate an efferent pathway, and stimulating the subject's vagus nerve to inhibit neural activity. Pairing activation of the efferent pathway and inhibition of neural activity can enhance an anti-inflammatory response of the subject.
US10981006B2 Hearing prosthesis emitting ultrasonic pulses
The invention relates to a hearing prosthesis having at least one acoustic converter for converting acoustic signals into electrical signals, and comprising an ultrasound device by means of which a multiplicity of focused, pulsed ultrasonic beams can be generated, wherein the ultrasound device can be fixed in the outer ear and/or outside the ear, and wherein, on the basis of electrical signals generated by the acoustic converter, the ultrasonic beams can be focused on to various physically distributed points in a region of the inner ear or in a region of the auditory pathway in the brain, while stimulating nerves.
US10981004B2 System for selective spatiotemporal stimulation of the spinal cord
The present disclosure refers to systems for electrical neurostimulation of a spinal cord of a subject in need of nervous system function support. In one example, a system comprises a signal processing device configured to receive signals from the subject and operate signal-processing algorithms to elaborate stimulation parameter settings; one or more multi-electrode arrays suitable to cover a portion of the spinal cord of the subject; and an Implantable Pulse Generator (IPG) configured to receive the stimulation parameter settings from the signal processing device and simultaneously deliver independent current or voltage pulses to the one or more multiple electrode arrays, wherein the independent current or voltage pulses provide multipolar spatiotemporal stimulation of spinal circuits and/or dorsal roots. Such system advantageously enables effective control of nervous system functions in the subject by stimulating the spinal cord, such as the dorsal roots of the spinal cord, with spatiotemporal selectivity.
US10981001B2 Systems and methods for automated capture threshold testing and associated his bundle pacing
A method of pacing a His bundle of a patient heart using a stimulation system including a memory, a pulse generator, a stimulating electrode and at least one sensing electrode includes applying a plurality of impulses through the stimulating electrode to induce a plurality of responses from the patient heart. Each impulse of the plurality of impulses is delivered at a different impulse energy corresponding to a respective output setting of the stimulation system. The response characteristics for each of the plurality of responses are measured and each impulse is assigned a classification based on whether the respective response characteristics indicate capture of one or both of the His bundle and a ventricle of the patient heart. The output setting and classification for each impulse is then stored in the memory.
US10981000B2 Self-expanding nerve cuff electrode
An electrode lead comprises an elongated lead body, at least one lead connector terminal affixed to the proximal end of the lead body, and an electrically insulative cuff body affixed to the distal end of the lead body. The cuff body is configured for being circumferentially disposed around a nerve. The cuff body comprises cutouts, slits, a wrinkled portion, a thin stretchable portion, and/or a serpentine strap, which increases that increase the expandability of the cuff body when disposed around the nerve. The electrode lead further comprises at least one electrode contact affixed to the cuff body, and at least one electrical conductor extending through the lead body between the at least one lead connector terminal and the electrode contact(s). If the cuff body comprises cutouts or slits, the electrode lead can further comprise a thin stretchable film affixed to the cuff body over cutouts or slits.
US10980996B2 Magnetically operated switches and methods of making magnetically operated switches
Magnetic orientation-independent magnetically actuated switches may be made by producing an outer cylinder and an actuator cylinder from ferromagnetic sheets and non-ferromagnetic sheets in alternating order. A first ferromagnetic body is attached to an end of the outer cylinder. The actuator cylinder is positioned within a first bore of the outer cylinder, the actuator pin is positioned within a second bore of the actuator cylinder and a third bore of the first ferromagnetic body with a portion of the actuator pin extending beyond the third bore of the first ferromagnetic body. A second ferromagnetic body is attached to the portion of the actuator pin, thus forming the magnetic orientation-independent magnetically operated switch.
US10980993B2 Microneedle, apparatus for manufacturing microneedle, and method of manufacturing microneedle using apparatus
Disclosed are a microneedle, an apparatus for manufacturing a microneedle including a support part containing a medicinal solution for coating a microneedle, a controller for controlling the temperature of the medicinal solution contained in the support part, and a dryer for drying the medicinal solution coated on the microneedle, and a method of manufacturing the microneedle using the apparatus. According to the configuration, the temperature of the medicinal solution can be adjusted such that a viscosity suitable for coating with the medicinal solution is maintained, whereby the quality of a microneedle coated with the medicinal solution can be improved, and denaturation of active ingredients in the medicinal solution can be prevented, which causes stability increase.
US10980988B2 Stent
A stent has a center length section, two end sections, and an elastically deformable woven wire mesh, which enables the stent to expand from a small diameter to a larger diameter, with the diameter of the end sections being larger than in the center length section in the expanded state. The wire extends in a zig-zag manner from an outer end of one end section toward the outer end of the other end section, and back in a zig-zag manner to the one end section. The peripheral direction of the woven wire changes at the transition from an end section to the center length section, such that the wire intersects on the return path to the one end section in the center length section and overall forms an 8-shaped loop having two closed eyes, wherein a plurality of interconnected loops are arranged offset to each other over the circumference.
US10980981B2 Procedural sheath
A procedural sheath and methods of use that assists in maintaining a fluid path while the procedural sheath is positioned within a vascular conduit of a patient. The procedural sheath includes one or more channels extending longitudinally along a working length of the body of the sheath. Each channel includes one or more fluid paths configured to allow blood to flow from the vascular conduit into a device receiving lumen of the sheath. One or more elongate members selectively coupled to the body operatively cooperate with the channels to fluidly control fluid access into the device receiving lumen through the fluid paths.
US10980978B2 Burr hole cap assembly with therapy delivery member orientation feature
In some examples, a burr hole cap assembly includes one or more markers that indicate a rotational orientation of a therapy delivery member relative to the burr hole cap assembly, where the therapy delivery member extends through an opening defined by the burr hole cap assembly. In addition, in some examples, the burr hole cap assembly includes a feature that indicates the rotational orientation of the therapy delivery member after the therapy delivery member is implanted in the patient. The feature can include the one or more markers in some examples.
US10980976B2 Deflectable sheath introducer
An introducer has a shaft with a central lumen, a control handle with a deflection assembly, and a tensile member with a distal portion extending along opposing sides of within the shaft and a proximal portion extending within the control handle. The deflection assembly has a deflection arm, and a rotatable member rotationally coupled to the deflection arm, wherein the rocker member has at least one pulley engaged with the proximal tensile member portion. Rotation of the deflection arm in one direction draws the proximal tensile member portion for deflecting the shaft.
US10980974B2 Methods of dispensing a urinary catheter from a sterile package
A packaged closed intermittent urinary catheter system equipped with a dispensing system and method of dispensing a packaged catheter using the dispensing system. The dispensing system is a pair of separately translatable movement control devices, each operably engaging the catheter for permitting unidirectional movement of the catheter in a first axial direction relative to the movement control devices. The movement control devices may be mounted to a hand-grippable assembly with a sliding or pivoting movable member reciprocal to a base member. Alternatively, the movement control devices are mounted to a coupling member and a spring member biases them apart.
US10980971B2 Surgical guide wire assembly
A guide wire assembly includes a dispenser coil, a guide wire and multiple clips. The dispenser coil is resilient and spirally coiled with coiled portions over an entire length of the dispenser coil. The guide wire is resilient and received inside the dispenser coil. The multiple clips are thermally joined to corresponding coiled portions of the dispenser partially over the entire length of the dispenser coil, and are spaced apart from each other by gaps. Each clip is resilient and has multiple circular grooves parallelly formed in and traversing across a bottom of the clip. The dispenser coil is partially thermally joined to the multiple clips and the coiled portions of the dispenser coil are uniformly curved and flush with each other, ensuring that the guide wire assembly can be produced in a time-saving fashion without compromising the capability against deformation to the guide wire.
US10980970B2 Ureteral and bladder catheters and methods of inducing negative pressure to increase renal perfusion
Ureteral catheters and assemblies are provided including: a drainage lumen including a proximal portion configured to be positioned in at least a portion of a patient's urethra and a distal portion configured to be positioned in a patient's ureter and/or kidney, the distal portion including a coiled retention portion including at least a first coil having a first diameter and a second coil having a second diameter, the first diameter being less than the second diameter; or wherein the retention portion extends radially outwardly from a portion of the distal end of the drainage lumen portion, the retention portion including a proximal end having a first diameter, a distal end having a second diameter, and a wall and/or surface extending therebetween, the retention portion having a second diameter is greater than the first diameter when deployed; or wherein the retention portion includes a plurality of drainage tubes.
US10980962B2 Breathing assistance apparatus
In one embodiment, a nasal cannula is shaped to fit within a user's nares, where the nasal cannula includes at least one prong allowing high flow delivery of humidified gases and creates positive airway pressure in the patient's airway. The prongs have angled ends such that, in use, gases flowing through the prongs are directed to the user's nasal passages. The nasal cannula body is partially swivelling and preferably has a ball joint connector. In another embodiment the nasal cannula may have at least one flared end prong that preferably seals within a patient's nare.
US10980961B2 Mask system
A mask system for delivery of respiratory therapy to a patient includes a nares portion and a mouth portion and an inlet conduit connected to at least one of the nares portion and the mouth portion to deliver the pressurized, breathable gas. The mask system is adapted to selectively utilize the nares portion and/or the mouth portion in a first mode utilizing both the nares portion and the mouth portion, and in a second mode utilizing the nares portion and not utilizing the mouth portion.
US10980957B2 Mask sizing tool using a mobile application
Apparatus and methods automate selection of patient interface(s) according to their size, such as with processing in a processor(s) or in a server(s). Image data captured by an image sensor may be received. The captured image data may contain facial feature(s) of an intended user of the patient interface. The facial features may be captured in association with a predetermined reference feature of known dimension(s). The user's facial feature(s) and the reference feature may be detected in the captured image data. Image pixel data of the image may be processed to measure an aspect of the detected facial feature(s) based on the reference feature. A patient interface size may be detected from standard patient interface sizes based on a comparison between the measured aspect of the facial feature(s) and a data record relating sizing information of the standard patient interface sizes and the measured aspect of the facial feature(s).
US10980954B1 Patient ventilator control using constant flow and breathing triggers
The embodied invention is a new inspiration/expiration ventilator flow design, with a constant inspiration flow and intermittent-concurrent expiratory flow based on lung pressure setpoints. This mode is possible by using a new dual lumen tube inserted into a patient Trachea. Additionally, the control provides support for patient initiated breathing which is initiated by a lung pressure drop. This control provides continuous and gentle recruitment of lung alveoli.
US10980953B2 Electronic cigarette
An electronic cigarette includes a liquid supply including liquid material, a heater operable to heat the liquid material to a temperature sufficient to vaporize the liquid material and form an aerosol, a wick in communication with the liquid material and in communication with the heater such that the wick delivers the liquid material to the heater, at least one air inlet operable to deliver air to a central air passage upstream of the heater, and a mouth end insert having at least two diverging outlets. The electronic cigarette can also include an air flow diverter which directs incoming air away from a heating zone of the heater.
US10980951B1 Nebulizer
This invention relates to nebulizers, which are machines that change a liquid form to a mist consisting of micron sized droplets. More specifically the invention relates to liquid medicament nebulizers, for example for delivering a mist of medicament to eyes, nasal passages, and lungs. A housing has a form which rolls to house first and second reservoirs, an expansion chamber, and a vibration element. The housing has a center of mass which urges the nebulizer to roll toward a storage position where the liquid drains from the first reservoir through the drain passage to the second reservoir.
US10980948B2 Labeling apparatus for a medical device
An apparatus for presenting an application status of a medical device that has a unused state and a used state. The apparatus includes a label having an electrochromic element. The label is at least partially disposed on an exterior surface of the medical device and is configured to display a predetermined feature in response to an electric current. A power source is disposed in or on the medical device for providing the electric current. A switch is configured to selectively connect or disconnect the label and the power source to one another for controlling the application of the electric current to the electrochromic element in response to actuation of the medical device from the unused state to the used state. The label may be scanned by a scan device that may connect to a medical organization for communicating information between the scan device and the medical organization.
US10980945B1 Syringe aid
A stretchy band that is placed over the plunger head of a syringe. The band is adhered to the underside of the plunger head. A thumb is snugly wrapped with the band to hold the thumb against the plunger head. The band is firmly secured around the thumb for operation of the syringe. A method of using this device is also disclosed.
US10980944B2 Syringe tip cap
A tip cap is provided comprising a base portion having an upper surface and a lower surface, a body having a top wall with a non-circular cross-section extending from the upper surface, and a shaft extending from the lower surface. A syringe assembly is provided comprising a syringe comprising a barrel, and a syringe tip, extending through the barrel and a connector provided on the syringe tip. The syringe assembly further comprises a tip cap for sealingly covering the syringe tip and comprising a base portion having an upper surface and a lower surface, a body having a top wall with a non-circular cross-section extending from the upper surface, and a shaft extending from the lower surface having connection means for attaching to the syringe tip.
US10980941B2 Methods for providing an alert or an alarm to a user of a mobile communications device
A computer-readable medium on a mobile computing device comprises an inter-application communication data structure to facilitate transitioning and distributing data between software applications in a shared app group for an operating system of the mobile computing device includes a scheme field of the data structure providing a scheme id associated with a target software app to transition to from a source software app, wherein the scheme id is listed on a scheme list stored with the source software app; and a payload field of the data structure providing data and/or an identification where to access data in a shared file system accessible to the software applications in the shared app group, wherein the payload field is encrypted.
US10980940B2 Medication tracking system
A method may include receiving, from a volume meter at a pump configured to deliver medication to a patient, data indicative of a volume of a medication present in a syringe inserted in the pump. A first counter may be updated, based on the data, in response to the medication being delivered to the patient as a first dose type. A second counter may be updated, based on the data, in response to the medication being delivered to the patient as a second dose type. The volume of the medication delivered to the patient may be determined based on the first counter and/or the second counter. An electronic alert may be sent to a mobile device in response to one or more anomalies being present in the volume of the medication delivered to the patient. Related methods and articles of manufacture, including apparatuses and computer program products, are also disclosed.
US10980939B2 Medicinal-liquid administering device
A device includes: a first member comprising a first-member-side power transmission part; and a second member comprising a second-member-side power transmission part configured to be attachable to and detachable from the first member, the second member being a part of a medicinal-liquid administering device. The first-member-side power transmission part and the second-member-side power transmission part are configured to be engaged with each other for administering a medicinal liquid into a living body. The second member is configured to open a housing covering the first-member-side power transmission part to engage the second-member-side power transmission part with the first-member-side power transmission part at a time of attaching the first member to the second member.
US10980936B2 Pen needle magazine
An attachable needle assembly (102) for use on a medication delivery pen (104), the needle assembly (102) comprising a housing (1 10) enclosing a hub (106) having a communication needle (108) configured to engage the medication delivery pen (104) and pierce a reservoir septum of the medication delivery pen (104), a communication septum (172, 176) of the needle assembly (102) defining a septum chamber (180, 182) that is in fluid communication with the communication needle (108), a plurality of needles (118) disposed in the communication septum (172, 176), a follower ring (130) that determines which needle (124) of the plurality of needles (118) is to be selected, and a snap ring (136) that exposes the selected needle (124) and moves the selected needle (124) in fluid communication with the septum chamber (180, 182), wherein when the housing (110) is in a first position, the plurality of needles (118) is not exposed, and when the housing (110) is in a second position, the selected needle (124) is in fluid communication with the septum chamber (180, 182) and exposed for medicament delivery.
US10980935B2 Enema device and method of using the same
An enema device and a method for using the same are disclosed. The enema device includes a non-plastic container and a liquid delivery tube. The non-plastic container is made of glass, stainless steel, or ceramic. The non-plastic container includes a bottom wall and an annular sidewall extending upwardly from the peripheral of the bottom wall, wherein the bottom wall has a bottom planar surface. The liquid delivery tube is in fluid communication with a containing chamber of the non-plastic container. Therefore, harmful effects to the human body from plasticizer can be prevented.
US10980931B2 System, method, and composition for removing uremic toxins in dialysis processes
Methods and devices for providing dialysis treatment are provided. The device comprises a cartridge for providing regenerative dialysis, the cartridge comprising: a body having an inlet and an outlet and defining an interior, the interior including at least a layer comprising urease, a layer comprising zirconium oxide, a layer comprising zirconium phosphate, and a layer comprising carbon, wherein at least two of the layers are blended together to provide a gradient of the two materials.
US10980928B2 Cardiac pump with speed adapted for ventricle unloading
A blood pump system is implantable in a patient for ventricular support. A pumping chamber has an inlet for receiving blood from a ventricle of the patient. An impeller is received in the pumping chamber. A motor is coupled to the impeller for driving rotation of the impeller. A motor controller is provided for tracking systolic and diastolic phases of a cardiac cycle of the patient and supplying a variable voltage signal to the motor in a variable speed mode to produce a variable impeller speed linked to the cardiac cycle. The impeller speed comprises a ramping up to an elevated speed during the diastolic phase in order to reduce a load on the ventricle at the beginning of the systolic phase.
US10980926B2 System and method for collecting plasma
A method for collecting plasma includes determining the weight and hematocrit of a donor, and inserting a venous-access device into the donor. The method then withdraws blood from the donor through a draw line connected to a blood component separation device, and introduces anticoagulant into the withdrawn blood. The blood component separation device separates the blood into a plasma component and a second blood component, and the plasma component is collected from the blood component separation device and into a plasma collection container. The method may then calculate (1) a percentage of anticoagulant in the collected plasma component, and (2) a volume of pure plasma collected within the plasma collection container. The volume of pure plasma may be based, at least in part, on the calculated percentage of anticoagulant. The method may continue until a target volume of pure plasma is collected within the plasma collection container.
US10980921B2 Methods of using water-soluble inorganic compounds for implants
A method for controlling generation of biologically desirable voids in a composition placed in proximity to bone or other tissue in a patient by selecting at least one water-soluble inorganic material having a desired particle size and solubility, and mixing the water-soluble inorganic material with at least one poorly-water-soluble or biodegradable matrix material. The matrix material, after it is mixed with the water-soluble inorganic material, is placed into the patient in proximity to tissue so that the water-soluble inorganic material dissolves at a predetermined rate to generate biologically desirable voids in the matrix material into which bone or other tissue can then grow.
US10980920B2 In situ forming hemostatic foam implants
Systems and methods related to polymer foams are generally described. Some embodiments relate to compositions and methods for the preparation of polymer foams, and methods for using the polymer foams. The polymer foams can be applied to a body cavity and placed in contact with, for example, tissue, injured tissue, internal organs, etc. In some embodiments, the polymer foams can be formed within a body cavity (i.e., in situ foam formation). In addition, the foamed polymers may be capable of exerting a pressure on an internal surface of a body cavity and preventing or limiting movement of a bodily fluid (e.g., blood, etc.).
US10980917B2 Adhesive stent coating for anti-migration
A stent, the stent including a first coating composition disposed on at least a portion of the outer surface of the stent, the first coating composition having at least one bioadhesive and a second coating composition disposed over the first coating composition, the second coating composition having at least one biodegradable polymer, and methods of making and using the same.
US10980916B2 Methods of preparing personalized blood vessels
The present disclosure relates to methods of preparing personalized blood vessels, useful for transplantation with improved host compatibility and reduced susceptibility to thrombosis. Also provided are personalized blood vessels produced by the methods and use thereof in surgery.
US10980910B2 Apparatus and methods for ozone generation and degradation
Devices and methods for sterilizing an enclosed space using ozone are disclosed herein. Various embodiments of the devices and methods also provide for accelerated degradation of the ozone upon sterilization. In some embodiments, a disclosed sterilization unit includes a first housing defining an ozone generation cavity, an ozone generator disposed within the ozone generation cavity, a second housing defining an ozone degradation cavity, and an ozone degrader disposed within the ozone degradation cavity. The sterilization unit of various embodiments is configured to cycle air between the enclosed space and the ozone generation cavity during an ozone generation cycle to sterilize the enclosed space; similarly, the unit is further configured to cycle air between the enclosed space and the ozone degradation cavity during an ozone degradation cycle to return the air within the enclosed space to safe ozone levels.
US10980905B2 Ozone sanitizing system and method
The present disclosure generally relates to an ozone sanitizing system and method. In one embodiment, a system for sanitizing various objects using ozone gas is disclosed. The system comprises an ozone generating device configured generate ozone gas for sanitizing one or more objects, and a vessel configured to couple with the ozone generating device for receiving the ozone gas to sanitize the one or more objects stored inside the vessel during an ozone sanitizing cycle. The system is configured to recirculate at least a gas mixture generated during the ozone sanitizing cycle to increase an ozone concentration inside the vessel.
US10980897B2 Methods and materials for GALGT2 gene therapy
The present disclosure relates to recombinant adeno-associated virus (rAAV) delivery of a GALGT2 polynucleotide. The disclosure provides rAAV and methods of using the rAAV for GALGT2 gene therapy of neuromuscular disorders. Exemplary neuromuscular disorders include, but are not limited to, muscular dystrophies such as Duchenne muscular dystrophy, Congenital Muscular Dystrophy 1A and Limb Girdle Muscular Dystrophy 2D.
US10980889B1 C40-, C28-, and C-32-linked rapamycin analogs as mTOR inhibitors
The present disclosure relates to mTOR inhibitors. Specifically, the embodiments are directed to compounds and compositions inhibiting mTOR, methods of treating diseases mediated by mTOR, and methods of synthesizing these compounds.
US10980886B2 Compositions of a polyorthoester and an organic acid excipient
Delivery systems and compositions comprised of a biodegradable polyorthoester polymer, an organic acid excipient, and a basic drug are described, along with related methods.
US10980881B2 Stable liquid formula having an anti-TNFalpha antibody, acetate buffer and glycine
Disclosed is a stable liquid formulation, comprising an antibody or antigen-binding portion thereof, an acetate buffer, glycine, and a surfactant, wherein the stable liquid formulation does not comprise at least one of sugar, a sugar alcohol and a metal salt, and the stable liquid formulation is still stable even upon high antibody content, and is superior in osmolality and viscosity, and subcutaneous administration thereof is possible.
US10980879B2 EGFR targeted therapy
The present invention relates to compositions and methods for treatment of neurological disorders. In particular, the present invention relates to EGFR as a clinical target for treatment of neurological disorders.
US10980874B2 Recombinant herpes simplex virus 2 (HSV-2) vaccine vectors
Recombinant herpes simplex virus 2 (HSV-2) vaccine vectors, virions thereof, compositions and vaccines comprising such, and methods of use thereof are each provided.
US10980872B2 Genetically stable live attenuated respiratory syncytial virus vaccine and its production
Provided herein are recombinant respiratory syncytial viruses that contain mutations that make the disclosed viruses attractive vaccine candidates. The viruses disclosed contain attenuating mutations designed to have increased genetic and phenotypic stability. Desired combinations of these mutations can be made to achieve desired levels of attenuation. Exemplary vaccine candidates are described. Also provided are polynucleotides capable of encoding the described viruses, as wells as methods for producing the viruses and methods of use.
US10980870B2 Proteins comprising MRSA Pbp2a and fragments thereof, nucleic acids encoding the same, and compositions and their use to prevent and treat MRSA infections
Nucleic acid molecules which encode an MRSA PBP2a protein or a fragment thereof which comprises at least 245 amino acid are disclosed. Compositions comprising the nucleic acid molecules are disclosed. Novel proteins which comprise a MRSA PBP2a protein or a fragment thereof which comprises at least 245 amino acid are disclosed are disclosed. Methods of inducing an immune response against MRSA PBP2a are disclosed, as are methods of treating an individual who has been diagnosed with MRSA and methods of preventing MRSA infection in an individual.
US10980867B2 Regulatory T cell epitopes, compositions and uses thereof
The invention is directed to T cell epitopes wherein said epitopes comprises a peptide or polypeptide chain comprising at least a portion of an immunoglobulin constant or variable region. The invention also relates to methods of using and methods of making the epitopes of the invention.
US10980863B2 Composition and methods for treating ischemic wounds and inflammatory conditions
Methods, compositions, and treatment protocols for treating ischemic wounds and inflammatory conditions in a patient. The treatment protocols comprise or consist of using a modified collagen gel (MCG) to promote healing of ischemic wounds and reduce inflammation at the wound site and in other inflammatory conditions. The modified collagen gel comprises generally a dispersion of collagens in an aqueous matrix comprising water and glycerine, where the amount of Type I collagen is greater than the amount of Type II and Type III collagens in the gel.
US10980862B2 Formulations of abaloparatide, transdermal patches thereof, and uses thereof
Disclosed are abaloparatide formulations for transdermal delivery of a therapeutically effective amount of abaloparatide, as well as transdermal patches prepared using these formulations, methods of preparing the disclosed formulations and patches, and methods of using these formulations and patches to treat osteoporosis, osteopenia, osteoarthritis, and/or bone fracture, improve bone mineral density (BMD), improve trabecular bone score (TBS), and treat, prevent, and/or reduce bone fractures.
US10980861B2 Glucokinase activator compositions for the treatment of diabetes
The present invention relates to the use of liver-selective glucokinase activators and a GLP1 analog in restoring insulin sensitivity and treating type II diabetes, including reducing body weight in subjects undergoing type II diabetes treatment.
US10980858B2 Trophic factor releasing agent and inflammatory disease treating agent
An object of the present invention is to provide a trophic factor releasing agent and an inflammatory disease treating agent in which an amount of trophic factors released from cells in a cell transplantation treatment or the like is increased. According to the present invention, there is provided a trophic factor releasing agent including a cell structure that includes biocompatible polymer blocks and cells and in which a plurality of the biocompatible polymer blocks are disposed in gaps between a plurality of the cells, in which a size of one of the biocompatible polymer blocks is 20 μm to 200 μm, and trophic factors are released from the cells.
US10980857B2 Treatment with GDF11 prevents weight gain, improves glucose tolerance and reduces hepatosteatosis
Disclosed herein are a means to prevent and/or ameliorate age, disease and obesity associated metabolic diseases, such as diabetes and impaired glucose tolerance. Also disclosed are compositions and methods that relate to the findings that GDF11 prevents weight gain, improves glucose tolerance and reduces hepatosteatosis in aged mice administered a high fat diet. In particular, the methods and compositions described herein relate to increasing the level of GDF11 in a subject, thereby treating or preventing the development of obesity in the subject, reducing the metabolic consequences of obesity and improving the subject's metabolic health.
US10980856B2 Composition and method for treating plantar fasciitis in humans
A topical, non-prescription formulation of essential oils combined with skin permeation enhancers for the clinical treatment of plantar fasciitis in humans. The formulation may exclude black pepper essential oil. The present compositions and methods relate to a method for treating a disorder chosen from plantar fasciitis, bursitis, or arthritis in humans in a patient in need thereof, comprising administering to the patient compositions having a therapeutically effective amount of a combination of isoprenoidal essential oils, for example, Tea Tree Oil and Clove Bud Oil, in combination with a skin permeation enhancer, such as DMSO, the administration comprising contacting an affected area of skin of the patient with the composition.
US10980854B2 Nutrition blend for health benefits in animals
A method of minimizing fat accumulation in a growing animal without limiting caloric intake or preventing or treating obesity in an animal, the method comprising orally administering a ketogenic diet and a nutrient blend to the animal. The nutrient blend can include at least four nutrients selected from the group consisting of walnut, maitake mushroom extract, EGCG, turmeric root powder, lycopene, taurine, EPA, and DHA to the animal.
US10980852B2 Method and compositions for treating viral infection
A method of treating viral infection, such as viral infection caused by a virus of the Filoviridae family, Flaviviridae family (Flavivirus genus), Deltaretrovirus genus, or Togaviriade family is provided. A composition having at least one cardiac glycoside is used to treat viral infection. The composition can further include at least one triterpene. Alternatively, the composition comprises at least one, at least two, or at least three triterpenes.
US10980851B2 Topical skincare compositions comprising Centella asiatica selected triterpenes
A topical skincare composition including a Centella asiatica extract including one or more triterpenes, wherein at least one of the one or more triterpenes is madecassic acid, an Avena (oat) extract, a ceramide and a dermatologically acceptable carrier. A method of treating symptoms of itch, redness, flaking, dryness, and/or roughness of the skin, scalp, and/or mucous membrane including the step of applying the topical skincare composition to at least a portion of a user's skin, scalp, and/or mucous membrane in need thereof.
US10980843B1 Bee venom nanoparticles
Bee venom nanoparticles and methods of synthesizing bee venom nanoparticles are provided. The bee venom nanoparticles may be synthesized by drying bee venom, suspending the dried bee venom in a solvent to form a first bee venom solution, spraying the first bee venom solution into boiling water under ultrasonic conditions to form a bee venom solution including the bee venom nanoparticles, stirring the bee venom solution including the bee venom nanoparticles, and freeze-drying the bee venom solution. The resulting nanoparticles may be used in pharmaceutical compositions, and may be useful for their antimicrobial activities.
US10980839B2 Method of preparing a faecal microbiota sample
The present invention relates to a method for preparing a fecal 5 microbiota sample of a donor subject. Said method includes the following steps: a) collecting at least one fecal microbiota sample from the donor subject; b) within a period of less than 5 minutes after collecting the sample, placing said sample obtained in step a) in an oxygen-tight collection device; c) mixing the sample obtained in step b) with at least one aqueous saline 10 solution containing at least one cryoprotectant and/or a filling agent; d) optionally, filtering the mixture obtained in step c), in particular by means of a filter comprising pores having a diameter of less than or equal to 0.7 mm, preferably less than or equal to 0.5 mm; and e) storing the mixture obtained in step c) or d) by freezing said mixture at a temperature 15 of between −15° C. and −100° C. Steps b) to e) are carried out in anaerobiosis.
US10980837B2 Lyophilized platelet lysates
The present disclosure is drawn to compositions and methods of making and using lyophilized platelet lysates. Specifically, a method of preparing a composition suitable for therapeutic use or as a culture medium can comprise steps of concentrating platelets from a platelet source to form a platelet rich portion of the platelet source, and lysing the platelets in the platelet rich portion to form a plurality of lysates. An additional step includes lyophilizing the lysates to form lyophilized platelet lysates in a composition with released concentrations of available growth factors, cytokines, and chemokines. In one example, at 30%, by platelet count, of platelets from a platelet source can be lysed using this process.
US10980836B1 Therapeutic cell compositions and methods of manufacturing and use thereof
The present disclosure provides compositions and methods for making and using engineered killer phagocytic cells for immunotherapy in cancer or infection by expressing a chimeric antigen receptor having an enhanced phagocytic activity, the chimeric receptor is encoded by a recombinant nucleic acid.
US10980828B2 Method of using cyclodextrin
Described are methods for using cyclodextrin to treat, inhibit, prevent, ameliorate, or cure diabetes or conditions relating to diabetes.
US10980815B2 Aminopyrimidinyl compounds
A compound having the structure: or an acceptable salt thereof, wherein X is N or CR, where R is hydrogen, alkyl, etc.; A is selected from the group consisting of a bond, C═O, —SO2—, etc.; A′ is selected from the group consisting of a bond, C═O, etc.; Z is —(CH2)h— or a bond, etc.; R1 and R1′ are independently selected from the group consisting of hydrogen, alkyl, etc.; R2 is selected from hydrogen, alkyl, etc.; R3 is selected from the group consisting of hydrogen, and amino; R4 is monocyclic or bicyclic, etc.; R5 is independently selected from hydrogen, alkyl, etc.; h, j, k, m, n and q are integers as defined in the specification. Also provided are methods of treatment as Janus Kinase inhibitors and pharmaceutical compositions containing the compounds of the invention and combinations with other therapeutic agents.
US10980814B2 Fused pentacyclic imidazole derivatives as modulators of TNF activity
Disclosed herein are compounds of formula (I) and pharmaceutically acceptable salt thereof, wherein variables X, R1, R2, and R3 are defined herein. These compounds are potent modulators of human TNFα activity and, accordingly, of benefit in the treatment and/or prevention of various human ailments, including autoimmune and inflammatory disorders; neurological and neurodegenerative disorders; pain and nociceptive disorders; cardiovascular disorders; metabolic disorders; ocular disorders; and oncological disorders.
US10980811B2 Reversal of fosfomycin resistance
Compounds, pharmaceutical compositions, and methods for reversing fosfomycin resistance are disclosed. Embodiments of the disclosed compounds inhibit fosfomycin-inhibiting enzymes. Some embodiments of the compounds are FosA inhibitors. The disclosed pharmaceutical compositions include (i) fosfomycin or a pharmaceutically acceptable salt thereof and (ii) a compound, or a pharmaceutically acceptable salt thereof, which inhibits a fosfomycin-inhibiting enzyme. A method of inhibiting growth of a fosfomycin-resistant bacterium includes contacting the bacterium with (i) fosfomycin or a pharmaceutically acceptable salt thereof and (ii) an effective amount of a disclosed compound or a pharmaceutically acceptable salt thereof.
US10980808B2 Calmodulin inhibitors, Chk2 inhibitors and RSK inhibitors for the treatment of ribosomal disorders and ribosomapathies
The present invention relates to methods, compositions and kits for treatment of ribosomal disorders and ribosomopathies, e.g. Diamond Blackfan anemia (DBA). In some embodiments, the invention relates to the use of novel classes of compounds, i.e. inhibitors of RSK (p90S6K); inhibitors of p70S6K; and inhibitors of rps6, to treat ribosomal disorders and ribosomopathies. In some embodiments, the invention relates to the use of specific Chk2 inhibitors and to the use of specific phenothiazine derivatives to treat ribosomal disorders and ribosomopathies, e.g. DBA.
US10980789B2 Therapeutic agent for fibrosis and inhibitor of nuclear translocation of phosphorylated Smad
A therapeutic agent for fibrosis, whose active ingredient is constituted by a glucosylceramide synthase inhibitor or lactosylceramide synthase inhibitor, or both, inhibits the nuclear translocation of phosphorylated Smad, thereby treating and preventing fibrosis.
US10980787B2 Drug for treating or preventing disorder caused by TGF-B signals, and application thereof
Provided is a drug or method for treating or preventing a condition, disorder, or disease of the corneal endothelium caused by transforming growth factor-β (TGF-β) signals, mitochondrial abnormalities, and/or endoplasmic reticulum (ER) associated stress in corneal endothelial cells, using p38 MAP kinase inhibitors. The present invention provides a drug which includes p38 MAP kinase inhibitors, and which is for treating or preventing a condition, disorder, or disease of the corneal endothelium caused by TGF-β signals and/or mitochondrial abnormalities in corneal endothelial cells. In the preferred embodiment, the condition, disorder, or disease of the corneal endothelium is Fuchs' corneal endothelial dystrophy.
US10980779B2 GFI1 inhibitors for the treatment of hyperglycemia
The present invention relates to methods and pharmaceutical compositions useful for the treatment of hyperglycemia. Thorough multiple analyses, inventors demonstrated that Gfi1 is expressed in pancreatic acinar cells, starting from the first stages of pancreatic embryonic development. Furthermore, they observed that Gfi1 mRNA levels remain steady throughout embryonic development, while they significantly increase during the first days of life. They challenged conditional mutant mice with high fat diet for 5 months and monitored their weight and glycemia weekly. All the animals displayed a rapid increase in body mass as expected. While control mice rapidly developed a massive hyperglycemia, mutant mice remained normoglycemic throughout the entire experiment. A similar protection from induced diabetes was observed upon treatment with a high dose of Streptozotocin. Accordingly, the present invention relates to a method of treating hyperglycemia in a subject in need thereof comprising administering to the subject a therapeutically effective amount of an inhibitor of Gfi1.
US10980777B2 Indole derivatives as histone demethylase inhibitors
The present application relates to compounds of formula (I), wherein A, R, R1, and R2 are as defined in the specification, pharmaceutical compositions containing such compounds and to their use in therapy.
US10980770B2 Treatment of circadian rhythm disorders
Embodiments of the invention relate to the use of a melatonin agonist in the treatment of free running circadian rhythms in patients, including light perception impaired patients, e.g., blind patients, and to methods of measuring circadian rhythm.
US10980766B2 Entacapone-related compounds to treat macular degeneration
The invention provides use of entacapone, an entacapone derivative or a stereoisomer, hydride, or pharmaceutically-acceptable salt thereof, in a person in need thereof, to treat or inhibit macular degeneration or age-related macular degeneration, and related compostions.
US10980764B1 Exogenous ketone supplements for reducing anxiety-related behavior
Methods of treating anxiety disorders or reducing anxiety-related behaviors. The methods include administering a therapeutically effective amount of ketone supplementation, such as butanediol, ketone esters (e.g., 1,3-butanediol-acetoacetate diester) and/or ketone salts (e.g., beta-hydroxybutyrate-mineral salt), chronically, sub-chronically, or acutely, with or without admixture with a medium chain triglyceride or in combination. It was determined herein that ketone supplementation reduced anxiety in rats on elevated plus maze as measured by less entries to closed arms, more time spent in open arms, more distance travelled in open arms, and delayed latency to entrance to closed arms, when compared to control. Along with reducing anxiety-related behavior, the chronic, sub-chronic, and acute ketone supplements also caused significant elevation of blood βHB levels and changed blood glucose levels.
US10980761B2 Treatment of nervous system disorders using combinations of RXR agonists and thyroid hormones
Disclosed herein are methods of treating disease with a combination of a RXR agonist and a thyroid hormone.
US10980760B2 Treatment of nervous system disorders using combinations of RXR agonists and thyroid hormones
Disclosed herein are methods of treating disease with a combination of a RXR agonist and a thyroid hormone.
US10980756B1 Methods of treatment
This disclosure features compounds and compositions that are useful in methods of treating coronavirus infections (e.g., useful in methods of treating COVID-19) in a subject in need thereof. The methods include administering to the subject niclosamide compounds (or pharmaceutically acceptable salts and/or co-crystals thereof, e.g., niclosamide). In some embodiments, the niclosamide compounds have one or more properties that include, but are not limited to: a particular purity (e.g., a chemical purity of greater than about 99.0%) or a particular particle size (e.g., a particular particle size distribution and/or a particular particle size range and/or a specific surface area range). In an aspect, the niclosamide compounds described herein (e.g., niclosamide) can form part of compositions, dosage forms (e.g., unit dosage forms), and the like, which are suitable for respiratory administration (e.g., via inhalation and/or intranasally). In another aspect, the niclosamide compounds described herein (e.g., niclosamide) can form part of compositions, dosage forms (e.g., unit dosage forms), and the like, which are suitable for administration to the GI tract (e.g., orally or rectally such as via enema)).
US10980751B2 Pharmaceutical or nutraceutical composition with resistance against the influence of ethanol
The invention refers to a pharmaceutical or nutraceutical composition comprising a core a) comprising an active ingredient and a water-insoluble polymer, a coating layer b) above the core a) comprising a salt of an alginic acid, and a coating layer c) above the coating layer b) comprising an anionic (meth)acrylate copolymer polymerized from a (meth)acrylate monomer mixture comprising 5-75% by weight in relation to the total weight of the (meth)acrylate monomer mixture of (meth)acrylate monomers with an anionic group, wherein the amount of the water-insoluble polymer in the core a) is 2 to 20% by weight in relation to the weight of the core a) and the amount of the salt of an alginic acid in the coating layer b) is 5 to 85% by weight in relation to the weight of the core a) and the amount of the anionic (meth)acrylate copolymer in the coating layer c) is 10 to 75% by weight in relation to the weight of the core a) and to the coating layer b).
US10980749B2 Therapeutic preparation comprising insulin for delivery into a lumen of the intestinal tract using a swallowable drug delivery device
Embodiments of the invention provide swallowable devices, preparations and methods for delivering drugs and other therapeutic agents within the GI tract. Many embodiments provide a swallowable device for delivering the agents. Particular embodiments provide a swallowable device such as a capsule for delivering drugs into the intestinal wall or other GI lumen. Embodiments also provide various drug preparations that are configured to be contained within the capsule, advanced from the capsule into the intestinal wall and degrade to release the drug into the bloodstream to produce a therapeutic effect. The preparation can be operably coupled to delivery means having a first configuration where the preparation is contained in the capsule and a second configuration where the preparation is advanced out of the capsule into the intestinal wall. Embodiments of the invention are particularly useful for the delivery of drugs which are poorly absorbed, tolerated and/or degraded within the GI tract.
US10980745B2 Microemulsion compositions
Provided are oil-in-water microemulsions for formulating pharmaceutically active compounds. The microemulsions contain oils, surfactants, water, and the pharmaceutical compounds, and are produced by mixing an aqueous phase and a lipid phase in which each phase contains at least one surfactant in a defined ratio whereby the resulting microemulsion has very small dispersed particles, and, is thermodynamically very stable.
US10980741B2 Compositions and methods for treating pterygium recurrence
Compositions and methods for inducing pterygium regression from visual axis/central cornea, stabilizing pterygium, treating hyperemia and symptoms in pterygium patients, and treating pterygium recurrence following pterygiectomy are disclosed. The methods include administration of a multikinase inhibitor, an antimetabolite or a combination thereof to patients in need thereof.
US10980738B2 Programmable pharmaceutical compositions for chrono drug release
The present disclosure provides programmable osmotic-controlled oral compositions providing delayed release of a therapeutically acceptable amount of a drug. The programmable osmotic-controlled compositions of the disclosure provide a lag time that is independent of the presence or absence of food, type of food, pH, gastric emptying, gastric motility, and volume and viscosity of gastric fluid. The compositions of the disclosure can be programmed to provide a desired and precise lag time, and release drug, after the lag time, at a rhythm, e.g., that matches the human circadian rhythm of a condition's symptoms and/or of the individual being treated in the application of the therapy to optimize therapeutic outcome and minimize side effects.
US10980728B2 Oral care compositions for promoting gum health
Oral care compositions comprising citrulline and stannous ion source with a specific pH range are provided for promoting Gum Health of a user.
US10980725B2 Cosmetic compositions and method of treating the skin
A compound that has retinol like properties is used in compositions for treating the skin.
US10980723B2 Non-aqueous composition for hair frizz reduction
A non-aqueous hair leave-on composition directed to an aqueous hair leave-on composition for hair frizz reduction comprising from about 0.15% to about 12.0% of a moisture control material or mixture of moisture control materials wherein the moisture control material is selected from one or more of the Class II groups a, b, c, d, e, f and g and wherein the moisture control material of Class II is weakly to non-acidic and further wherein the moisture control material of Class II has protein binding higher than 10 and molecular volume lower than 1500 and log P higher than 0.5 and pKa of 5 or higher and hydrogen-binding higher than 4; and wherein, the non-aqueous carrier is selected from a group consisting of a) hydrocarbons b) silicone fluid c) non-hydrocarbons volatile organic solvents or mixtures thereof.
US10980721B2 Cosmetic product to prevent body odor with an improved long-term effect
The present disclosure relates to cosmetic agents, which in addition to a deodorant agent contain a combination of special aromatic alcohols and certain menthyl compounds. These agents have a long-lasting deodorizing effect. The present disclosure also relates to a cosmetic product that includes the cosmetic agent as contemplated herein, as well as at least one propellant. The present disclosure also relates to the use of the agent as contemplated herein to treat body odor, as well as the use of a combination of aromatic alcohol and menthyl compounds to improve the odor-inhibiting effect of cosmetic agents over a period of from about 24 to about 48 hours.
US10980718B2 Personal care compositions comprising poorly soluble compounds
A water-in-oil personal care emulsion with water droplets size below 20 microns, the droplets containing solubilized cystine. A process of making an emulsion is also described.
US10980715B2 Gel composition, cosmetic, and method for producing gel composition
There is provided a gel composition that can be suitably used as a thickener for cosmetic preparations and the like. A gel composition comprising a neutralized product of an alkyl-modified carboxyl group-containing polymer, which is a copolymer of monomers comprising 100 parts by mass of (meth)acrylic acid (a), 2.5 to 5 parts by mass of a (meth)acrylic acid alkyl ester (b) in which the alkyl group has 18 to 24 carbon atoms, and 0.1 part by mass or less of a compound (c) having two or more ethylenically unsaturated groups; and at least one of an anionic emulsifier and a nonionic emulsifier.
US10980713B2 Dental composition
Disclosed is a resin modified dental luting cement composition having a polymerizable resin component, a polyacidic polymer component, a filler component, a redox initiator system, and water.
US10980712B2 Photochromic dental material with encapsulated photochromic colorants
Radically polymerizable dental material, which contains at least one encapsulated photochromic colorant.
US10980710B2 Method for preparing medical/chemical solution and medical/chemical solution preparation system
A method is for preparing a medical/chemical solution by mixing a medical/chemical substance housed in a sealed container with a solution housed in a bag. The method includes transferring, from the bag into a syringe, an amount of the solution that is to be injected into a plurality of the containers. With the container and the syringe being held, at least one of a robot and a syringe driver configured to drive a plunger of the syringe is controlled so as to inject the amount of the solution into the plurality of the containers from the syringe.
US10980708B2 Systems, methods and kits for cleansing an ocular region
Systems, methods, and kits useful for cleansing the eyelids and maintaining eyelid hygiene are disclosed. In one embodiment, a system for treating or cleansing an ocular region is disclosed. The system consists essentially of: (A) a tubular applicator, wherein the applicator comprises: (i) a first chamber and a second chamber; and (ii) a sealable element situated between the first chamber and the second chamber, wherein at least the second chamber is substantially pre-filled with an ocular composition, and (B) a dispenser, wherein the dispenser is bonded to an external surface of a first end of the applicator.
US10980706B2 Mobile device control
A system for assisting a rescuer with treatment of a patient comprising a mobile computing device that includes a user interface and a processor coupled to memory. The processor configured to cause the user interface to prompt the rescuer to select a proficiency level from a plurality of proficiency levels, the plurality of proficiency levels comprising a basic proficiency level and at least one non-basic proficiency level, wherein the basic proficiency level includes basic resuscitation instructions for the rescuer. The system further configured to receive an input from the rescuer of the selected proficiency level. The system provides, if the rescuer selects the basic proficiency level, the basic resuscitation instructions to the rescuer and provide, if the rescuer selects the at least one non-basic proficiency level, non-basic instructions to the rescuer. Lastly, the system transmits signals to control a defibrillator according to the selected proficiency level.
US10980702B2 Portable deep vein thrombosis compression device having an integrated pressure cuff and utilizing a disposable cuff barrier
A portable compression system for preventing deep vein thrombosis is provided. The portable compression system includes an inflatable apparatus comprising a monitor unit and at least one inflatable air cell. The portable compression system further includes an outer cuff comprising a pocket configured to receive the inflatable apparatus, the outer cuff configured to be wrapped around a portion of a patient's body where prevention of deep vein thrombosis is desired. The portable compression system further includes a disposable sleeve barrier configured to provide a physical barrier between the outer cuff and the portion of the patient's body.
US10980699B2 Walking assistance apparatus and control method
A walking assistance apparatus includes a suit to be worn on a knee and waist of a user, a first wire that couples a portion included in the suit and worn above the knee to a portion included in the suit and worn on the waist, a second wire that couples a portion included in the suit and worn above a back of the knee to a portion included in the suit and worn on the waist, and motors coupled to the first and second wires. The motors are controlled to generate tensions so that each of the first and second wires has a stiffness greater than 200 N/m during a first period including a period of 95% or more and 100% or less of a first gait cycle of the user and a period of 0% or more and 50% or less of a second gait cycle subsequent to the first gait cycle.
US10980697B2 Method of attaching an artificial tendon and a product
Provided is a technique for attaching an artificial tendon to a support device having a supporting material as well as a product formed by the technique. The artificial tendon is provided for flexing or extending a joint of a body, when applied at the joint of the body, by way of pulling the artificial tendon along its lengthwise direction. The artificial tendon is attached to the support device by stitching across the tendon with a thread on the supporting material of the support device, which forms a tunnel for the artificial tendon between the supporting material and the stitching. The artificial tendon is able to travel in the tunnel. The tunnel formed by this technique is positioned on the surface of the supporting material of the support device.
US10980693B2 Modular patient positioning system
During orthopedic surgeries, body parts are moved in different ways to cause different anatomic features (e.g. muscles or the trochanters) to tighten or loosen, or become more or less prominent during the intended surgical incisions, which can result in easier surgical procedures. Body parts can be moved using a variety of different structures. The exemplary structures described herein can allow for: (1) a person's leg and foot to be rotated about the axis of the leg (i.e., femur/tibia axis); (2) a person's leg can be pivoted generally about the hip/femoral head/acetabulum to vary the angle between the axis of the leg and a median sagittal plane; (3) a person's leg can be moved in a direction parallel to the leg axis; and/or a person's leg can be pivoted in a generally vertical plane, about the femoral head/acetabulum while the axis of the leg and the median sagittal plane remaining substantially parallel.
US10980688B1 Hospital bed with pivoting side rail
The hospital bed with pivoting side rail includes a bed frame having a headboard, a footboard and a platform mounted thereon. The side rail has an upper end, a lower end, and first and second longitudinally opposed sides. The lower end of the side rail is pivotally attached to the bed frame, and the upper end of the side rail is releasably attached to the headboard and the footboard. In order to safely and easily deploy and collapse the side rail, first and second adjustable struts are provided, the struts having opposed first and second ends, such that the first ends of the first and second adjustable struts are pivotally attached to the first and second sides of the side rail, and the second ends of the first and second adjustable struts are pivotally secured to the headboard and footboard, respectively.
US10980687B2 Techniques for generating auditory and haptic output with a vibrational panel of a patient support apparatus
A patient support apparatus comprises a base and a support structure coupled to the base and being configured to support a patient. The apparatus also comprises a panel having a surface and being physically adapted to vibrate at one or more frequencies, a controller configured to generate an electrical signal, and a vibrational exciter. The vibrational exciter comprises a surface coupled to the surface of the panel and being configured to receive the electrical signal from the controller and to convert the electrical signal into vibrational energy. The surface of the vibrational exciter is configured to transfer the vibrational energy to the surface of the panel to vibrate the panel at the one or more frequencies.
US10980685B2 Connection assembly for coupling an auxiliary drive system to a wheelchair for disabled people
A connection assembly for coupling an auxiliary drive system to a wheelchair for disabled people, of the type comprising a fixing structure adapted to be fixed to the framework of the wheelchair and a longitudinal member operatively connected to the fixing structure so that the longitudinal development axis of the longitudinal member is substantially parallel to the advancement direction of the wheelchair. The connection assembly comprises connection means associated with the free end of the longitudinal member and with the auxiliary drive system, such connection means are configured to allow rapid coupling and decoupling of the auxiliary drive system to/from the wheelchair.
US10980679B2 Absorbent article having waist gasketing element
An absorbent article for wearing about the lower torso of a wearer includes a first waist region having a first waist edge, a second waist region having a second waist edge, and a crotch region disposed between the first and second waist regions. The article further includes a first longitudinal edge, a second longitudinal edge, and a chassis having a topsheet, a backsheet, and an absorbent core disposed between the topsheet and backsheet. A waist gasketing element is joined to the chassis and disposed in one of the first waist region or the second waist region. The waist gasketing element has a top layer and a bottom layer, an inboard lateral edge and an outboard lateral edge, and first area, A1. The top layer is bonded to the bottom layer in a closure bond region by a closure bonding technique. The closure bond region has an aggregate closure bond area, BA, which is at least about 10% of the first area, A1.
US10980667B2 Eye treatment devices and methods
Devices can be implanted in an eye to treat a dry eye condition. The devices include a body defining a lumen and having first and second ends and external and lumenal surfaces. The body has a length sufficient to provide fluid communication between the anterior chamber and tear film of the eye through the lumen when the device is implanted in the sclera. In some embodiments, the device is filterless. In some embodiments, a filter is included. The dry eye treatment devices provided herein prevent bacterial ingress, provide outflow resistance to retain a normal intraocular pressure, and provide moisture (e.g., aqueous humor) to an otherwise dry eye. Methods of treating a dry eye condition wherein the device is implanted in the sclera of an afflicted eye are also described.
US10980665B2 Heat generator
The purpose of the present invention is to provide a heat generator that contains a volatile component and in which the volatile component is stably maintained during storage, the volatile component is prevented from adhering to a heat-generating section, and it is possible to achieve an excellent warming effect during use. This heat generator comprises a heat-generating section (1), an accommodation body (2) for accommodating the heat-generating section (1), an adhesive layer (3) provided to an attachment surface side of the accommodation body (2), and a release sheet (4) provided to the attachment surface side of the adhesive layer (3). As a result of including a volatile component in the adhesive layer (3) and respectively providing gas barrier layers (211), (41) to a first packaging material (21) constituting the attachment surface side of the accommodation body (2) and to the release sheet (4), it is possible to stably maintain the volatile component within the adhesive layer (3) during storage. It is thereby possible to prevent the volatile component from adhering to the heat-generating section (1) during storage and to achieve an excellent warming effect during use.
US10980664B2 Systems and assemblies for ostomy appliances
The present subject matter relates to medical devices for ostomy applications, specifically a floating ring design for securing robust attachment between the flange surrounding a stoma on a patient's body and an ostomy bag. Existing ostomy appliance designs present significant drawbacks related to routine, high replacement cost and poor performance, the latter resulting in anxiety, grief over fear of stool leakage due to rapid, sudden and/or unexpected detachment or mechanical compromise of ostomy appliance components. This further includes discomfort due to the mechanical stresses placed on the subject's body.
US10980662B2 Asymmetric multilayer film for ostomy application
An asymmetric multilayer film for an ostomy pouch includes a barrier layer including a first side and a second side. At least one layer is arranged on the first side of the barrier layer, and at least one layer arranged on the second side of the barrier layer, in which the combined thickness of the at least one layer arranged on the first side of the barrier layer is at least two times greater than the combined thickness of the at least one layer arranged on the second side of the barrier layer. The asymmetric multilayer film has a thickness of about 25 μm to about 50 μm.
US10980660B2 Quick release restraint ring
The present invention comprises a kit of a restraint ring, a base and a quick release, tamper resistant fastener. The base is adapted to attach to a fixture. The fixture may be a bed, chair, floor or wall. The base may be attached using tamper resistant fasteners. The base may be permanently attached or may be removably attached. The base is adapted to releasably receive the quick release fastener thereby attaching the restraint ring to the base.
US10980658B2 Nasal support device
A nasal support device includes a device body. The device body defines a perimeter shape of the nasal support device and also can include a nasal support structure. The nasal support device also includes adhesive carried with the device body. The nasal support device further includes a peelable backing that covers the adhesive and includes at least one peelable backing piece that is divided into a first section and a second section by a pre-defined fold location. The pre-defined fold location is configured such that the first and second sections of the peelable backing piece remain coupled together at the pre-defined fold location after folding at the pre-defined fold location.