| Document | Document Title |
|---|---|
| US10544689B2 |
Hybrid blade for turbomachines
A blade for a turbomachine comprising an outer shell and an inner core which is at least partially enclosed by the outer shell and has a higher porosity than the outer shell. The outer shell is formed by a ceramic body or a body made of a ceramic matrix composite material, and the inner core is formed by a fiber-reinforced ceramic or a fiber-reinforced ceramic matrix composite material. |
| US10544688B2 |
Mechanical reinforcement for a part made of composite material, in particular for a wind turbine blade of large dimensions
The invention relates to a reinforcement, containing fibers and resin, for an element made of a composite material, particularly a wind turbine blade, characterized in that said reinforcement is produced by stacking at least two parts produced by pultrusion. A reinforcement, containing fibers and resin, for an element made of a composite material, particularly a wind turbine blade, is characterized in that the reinforcement is produced by stacking at least two parts produced by pultrusion. |
| US10544687B2 |
Shrouded blade of a gas turbine engine
The present invention relates to an improved cast-to-size gas turbine blade comprising a blade tip shroud with a stiffening rib extending outwardly from the section of the outer side of the shroud platform located between the upstream sealing fin and the upstream edge. The stiffening rib having substantially planar top surface in form of a trapezium, and two sloping sidewalls extending between the upstream sealing fin and the upstream edge on each side of the top surface and connecting said top surface with adjacent surface of the outer side of the shroud platform. The form of the stiffening rib allows to obtain an improved shroud configuration of reduced overall blade mass, capable of providing sufficient stiffening of the shroud, reducing vibrations of the shroud platform, creep curling of the shroud edges and bending stress at the intersection of the airfoil and of the shroud. |
| US10544686B2 |
Turbine bucket with a cooling circuit having asymmetric root turn
The present application provides a turbine bucket. The turbine bucket may include a platform, an airfoil extending from the platform at an intersection thereof, and a cooling circuit extending within the platform and the airfoil. The cooling circuit may include a root turn with an asymmetric shape so as to reduce stress concentrations therein. |
| US10544685B2 |
Turbine vane, turbine, and turbine vane modification method
A turbine vane (3) includes: a vane body (21); a plate-like inner shroud (22) provided at a radially inner end of the vane body (21); and a plate-like outer shroud (23) provided at a radially outer end of the vane body (21). The vane body (21) includes a serpentine channel (30) which is formed so as to meander inside the vane body (21) in the radial direction and through which a cooling medium flows. The inner shroud (22) includes a cooling path (40) which has one end open at the downstream end side of the serpentine channel (30) and the other end open at a trailing edge (22D) of the inner shroud (22) and through which the serpentine channel (30) communicates with the outside of the inner shroud (22). |
| US10544673B2 |
Apparatus and method using measurements taken while drilling cement to obtain absolute values of mechanical rock properties along a borehole
An innovative apparatus and computer implemented methods to obtain values for a set of scalars corresponding to each force and displacement, which may be obtained from acoustical signals captured by sensors of a drill bit while drilling, in a material of known mechanical properties, such as a cement from casing the well, such that the application and use of the scalars in relation to measurements of the mechanics while drilling, such as the acceleration of the bit and motion of the bit captured by sensors such as accelerometers, allow for absolute values of mechanical rock properties to be obtained in rock formations, being drilled through, with otherwise unknown mechanical properties prior to drilling. |
| US10544669B2 |
Surface ranging technique with a surface detector
A system for electromagnetic wellbore surface ranging to determine the location of a second wellbore relative to a first wellbore utilizing i) a current source configured to directly inject electrical current into a conductive member disposed in each wellbore and ii) an electromagnetic senor positioned on the surface of a formation, the sensor configured to measure electromagnetic fields at the formation surface emanating from the conductive member within each wellbore. |
| US10544667B2 |
Modeling of interaction of hydraulic fractures in complex fracture networks
Methods of performing a fracture operation at a wellsite with a fracture network are provided. The methods involve obtaining wellsite data and a mechanical earth model, and generating a hydraulic fracture growth pattern for the fracture network over time. The generating involves extending hydraulic fractures from a wellbore and into the fracture network of a subterranean formation to form a hydraulic fracture network, determining hydraulic fracture parameters after the extending, determining transport parameters for proppant passing through the hydraulic fracture network, and determining fracture dimensions of the hydraulic fractures from the hydraulic fracture parameters, the transport parameters and the mechanical earth model. The methods also involve performing stress shadowing on the hydraulic fractures to determine stress interference between fractures and repeating the generating based on the determined stress interference. The methods may also involve determining crossing behavior. |
| US10544664B2 |
Microbially enhanced thermal oil recovery
A method and a system for recovering oil from currently inaccessible oil containing geological units by activating the deep biosphere microbial seed bank. Nutrient and thermal enhancement of microorganisms in oil containing geological units allows for stimulation of inactive and/or dormant microorganisms such that they proliferate and produce gas. The oil viscosity that is decreased by heat, along with the gas pressure produced by activated microbes which allows previously inaccessible oil to flow toward production wells. |
| US10544663B2 |
Method of well completion
A method for well completion employs a combined plugging and perforating operation for creating multiple spaced-apart clusters of perforations and optional stimulation treatments in stages. For each stage to be completed, a frac plug, carried, for example, along a wireline bottom hole assembly with perforating guns, is set in the wellbore distal (toward the toe end of the well) of the most proximal perforation cluster of the previous stage, thereby maintaining open hole conditions that provide adequate flow past the most distal perforation clusters in the current stage and minimizing proppant accumulation in the wellbore from stimulation operations. The method further allows subsequent pump down of tools and equipment even with the plug set in the wellbore. |
| US10544662B2 |
Hydraulically actuated double-acting positive displacement pump system for producing fluids from a deviated wellbore
A submersible, hydraulically actuated, multi-stage double-acting positive displacement pump system is provided. The system has a hydraulically actuated reciprocating linear double-acting motor centrally disposed between and connected to double-action fluid pumps on either side of the motor, with pistons of each of pump and the motor all in the annular space between an inner wall of the apparatus' cylindrical body and the outer wall of a cylindrical production fluid conduit concentrically disposed within the body, to pump wellbore fluid from outside the assembly through the pumps and into the central production fluid conduit. The rate and direction of hydraulic fluid flow through the actuator may be controlled by VFD motors and PLC controller on the ground, and through at least one electromechanical valve and two limit switches mounted to the downhole components. |
| US10544661B2 |
Apparatus and methods for enhanced well control in slim completions
A system to enhance well control in slim completions in an oil well includes an electrical submersible pump (“ESP”) positioned within a casing and having at least a portion thereof extending outwardly from a production tubing positioned within the casing. The production tubing terminates adjacent a distal end portion of a pump discharge to thereby provide greater interstitial space between outer surfaces of the portion of the pump disposed to extend outwardly from the production tubing and inner walls of the casing. This increased interstitial space, for example, can assist in cost savings by reducing the rate of erosion damage to the ESP. Embodiments of the present invention can further include a valve connected to inner walls of the casing and positioned distal from the ESP to control the flow of hydrocarbons. |
| US10544658B2 |
Underwater control device and control system for an underwater hydrocarbon production facility
An underwater control device for an underwater hydrocarbon production facility having an underwater box defining a housing chamber; an active electronic component with a switching and/or isolation function, housed in the housing chamber; a polymer block in which the active electronic component is embedded, and which is housed in the housing chamber; and electrical connectors extending through the underwater box and configured to connect the active electronic component to a network of a control system. |
| US10544657B2 |
Apparatus and methods for well intervention
A downhole tool string for conveying within a wellbore, including an engagement device for engaging a downhole feature located within the wellbore, a first actuator for applying a substantially non-vibrating force to the engagement device while the engagement device is engaged with the downhole feature, and a second actuator for applying a vibrating force to the engagement device while the engagement device is engaged with the downhole feature. |
| US10544654B2 |
Well tool device with a frangible disc
A well tool device may include a housing having an inner surface defining a through bore. Additionally, the well tool device may include a frangible disc including an upper chamfered supporting surface and a lower chamfered supporting surface and is supported by a seat in relation to the housing. Further, a force transmitting device is provided between the frangible disc and the seat. The force transmitting device may include an upper contact ring provided between the upper chamfered supporting surface of the frangible disc and the seat and a lower contact ring provided between the lower chamfered supporting surface of the frangible disc and the seat. |
| US10544651B2 |
Pressure balanced setting tool
A system including a downhole device coupled to a pressure balanced setting tool. The setting tool may be pressure balanced to lock a setting piston in place as the system is deployed into a well. That is, in spite of downhole well pressures, no substantial differential may emerge between the setting piston and the annular space of the well adjacent the system. Thus, the setting piston may remain locked in place until triggered for setting. This may include breaching a rupture disc of another piston to disrupt hydraulic communication between the setting piston and the annular space. This allows subsequent triggering, for example through another breach of a rupture disc defining a volumetric chamber, to take place in a manner that allows stroking of the setting piston. In this way, the setting tool may be utilized to achieve setting of the downhole device. |
| US10544648B2 |
Systems and methods for sealing a wellbore
Systems and methods for sealing a wellbore are described. The system includes a packing element configured to at least partially seal an uphole portion of a wellbore from a downhole portion of the wellbore. A first annular pressure sensor is positioned uphole of the packing element. The first annular pressure sensor is configured to measure a first pressure within the wellbore uphole of the packing element. A second annular pressure sensor is positioned downhole of the packing element. The second annular pressure sensor is configured to measure a second pressure within the wellbore downhole of the packing element. A control sub-assembly is configured to be positioned within the wellbore. The control sub-assembly is configured to monitor a sealing efficiency of the system by comparing the first pressure and the second pressure. |
| US10544642B2 |
Adjustable lock-out ram for production BOP applications
Systems and methods for gripping a polished rod that extends into a hydrocarbon production well include a clamping assembly that is moveable between an unengaged position where the clamping assembly is spaced apart from the polished rod, and an engaged position where the clamping assembly engages the polished rod. The clamping assembly includes a recess located in a moveable clamping member, the recess having a supporting surface. The clamping assembly also includes an adapter sized to fit within the recess and to be supported on the supporting surface, the adapter having a gripping surface facing out of the recess. The adapter is positioned to grip the polished rod with the gripping surface when the clamping assembly is in the engaged position. |
| US10544637B2 |
Downhole flow diversion device with oscillation damper
A device for limiting the flow of drilling fluid through a section of drill string is described. The device includes a cylindrical tube with holes in its periphery. Flow enters the device through an upper end of the tube and a portion of the flow exits through the lower end of the tube. In addition, some of the flow is diverted through the peripheral holes. A valve piston is supported near the lower end of the tube by a spring of approximately constant force through its range of travel. The valve piston moves axially as the flow rate through the tube changes flow rate to ensure that a substantially constant amount of flow exits through the lower end, while the excess flow is diverted from the tube through the peripheral holes. A means of damping or stopping the axial movement of the valve piston is included in the device. |
| US10544636B1 |
Guide plate for tubular handling tools
A tubular handling tool includes a body having a center hole adapted to receive a tubular, a guide plate positioned about a top end and a bottom end of the center hole, and a plurality of rollers coupled to the guide plates. Each of the rollers are rotatable about a rotational axis that is parallel to a longitudinal axis of the center hole. |
| US10544633B2 |
Moveable hoisting system
A hoisting system is disclosed including a moveable sheave coupled to a well support structure, the moveable sheave slideable along the well support structure and relative to a fixed sheave to laterally move a hoisting line relative to a well center. The hoisting system may include a second moveable sheave such that a second hoisting line may be laterally moved to various locations including a second well center or the same well center as the first hoisting line. |
| US10544632B2 |
Coiled tubing electrical power splice
A splice connects segments of coiled tubing and power cable together. The splice has a base and a head, each having an interior conical surface and a collet with fingers that deflect inward in gripping engagement with one of the segments in response to axial movement of the head collet and the base collet. A compression sleeve extends between the base collet and the head collet and exerts forces on the collets while the base and head are being secured together. An insulator tube slides over each of the power conductors. A retainer ring for each insulator tube grips one of the power conductors and abuts a shoulder in the insulator tube to prevent movement of the insulator tube along the power conductor. |
| US10544631B2 |
Combined multi-coupler for top drive
In one embodiment, a coupling system for a top drive and a tool includes a housing of the top drive having a bore therethrough, an adapter of the tool, a latch member at least partially disposed within the housing and radially movable between an extended position and a retracted position, wherein the latch member is configured to longitudinally couple the housing to the adapter, and a lock member at least partially disposed within the housing and longitudinally movable relative to the housing, wherein the lock member is configured to move the latch member between the extended and the retracted positions. |
| US10544627B2 |
Polycrystalline diamond constructions with protective element
PCD constructions as disclosed comprise a ultra-hard body attached with a metallic substrate along a substrate extending between the body and the substrate. The construction includes a protective feature or element that is configured to protect a metal rich region or zone existing in the construction from unwanted effects of corrosion or erosion. The protective element extends from the body over the interface and along a portion of the substrate and may be integral with the. |
| US10544622B2 |
Wired pocket
A window shade pocket system comprises a pocket having an inside surface, a bracket removably affixed to the inside surface of the pocket and a roller shade within the pocket. The bracket may retain cabling and/or electrical components within the bracket. The bracket may include a plurality of brackets along the inside surface of the pocket, wherein the cabling is retained within the plurality of brackets. The brackets may form a channel between the bracket and the inside surface of the pocket. The roller shade may be able to be removed after the bracket is removed. The pocket may also be comprised of a first component having a first engagement device and a second component having a second engagement device, wherein the first engagement device engages the second engagement device to form the pocket. |
| US10544615B2 |
Actuator for opening and closing a vehicle door
An actuator includes a yoke having an inner circumferential surface; an armature including a rotary shaft provided inside the yoke; a drive shaft configured to be driven to rotate when receiving a rotating force from the rotary shaft; a cylindrical first housing; a second housing relatively movable with respect to the first housing; a speed reduction gear part is disposed between the rotary shaft and the drive shaft; and a driven member is connected to the drive shaft for moving in an axial direction of the drive shaft in response to rotation of the drive shaft. The yoke is disposed within the first housing and a damper member is disposed between the first housing and the speed reduction gear part. |
| US10544613B2 |
Security-enhanced garage door opener system
This invention is about an improved garage door opener system, with design features for preventing garage door break-in from outside of the garage using an object such as a hanger. Typically, a person pulls down a cord connected to a release handle to release emergency release of a garage door opener, allowing the door to be manually open or closed. An unauthorized person may attempt to pull down the cord using a hanger from outside the garage or to pull or push down the release handle, to open the door from outside and gain unauthorized entrance. The improved garage door opener system provides a mechanism to reverse the pulling direction of the cord and also protects release handle from being accessed from outside the garage, for increased security. |
| US10544608B2 |
Glovebox controller systems and methods
Techniques are disclosed for systems and methods to control a vehicle accessory actuator for an actuated vehicle accessory, such as an actuated glovebox in the cockpit of a vehicle. A vehicle accessory control system includes a vehicle accessory actuator and a logic device configured to control operation of the vehicle accessory actuator. The vehicle accessory actuator is configured to unlatch or otherwise control operation of a vehicle accessory. The logic device is configured to receive an unlatch or other control command associated with the vehicle accessory, determine an operating temperature, other environmental condition, or operational status associated with the vehicle, vehicle accessory, or vehicle accessory actuator, and to provide an actuator control signal to the vehicle accessory actuator to unlatch or otherwise control operation of the vehicle accessory, where electrical characteristics of the actuator control signal are based on the determined operating temperature, other environmental condition, or operational status. |
| US10544606B2 |
Door lock control system and door lock apparatus
A door lock control system includes a first device including a first transmitter, a first receiver, and a first controller configured to measure first signal strengths of radio signals received from a plurality of surrounding devices by the first receiver, and control the first transmitter to transmit the measured first signal strengths to a second device. The system further includes the second device including a second receiver and a second controller configured to measure second signal strengths of radio signals received from a plurality of surrounding devices by the second receiver, control the second receiver to receive the first signal strengths from the first device, compare the first signal strengths with the second signal strengths, and control a door lock based on the comparison of the first and the second signal strengths. |
| US10544603B1 |
Fluorescent doorknob assembly
A fluorescent doorknob assembly for illuminating a doorknob in a darkened environment includes a doorknob that is rotatably mounted on a door for opening the door. A light emitter is coupled to the doorknob. The light emitter is comprised of a fluorescent material thereby facilitating the light emitter to emit light in a darkened environment. In this way the light emitter illuminates the doorknob thereby making the doorknob visible to a user a night. |
| US10544602B1 |
Two-piece striker plate
A system and method for adjusting the location of the striker plate relative to the throw of a lock includes two plates, and upper plate and a lower plate, that adjustably translate relative to each other. The lower plate is affixed to a door jamb and the other plate slides relative to the upper plate. This adjustable striker plate system provides users with the ability to relocate the upper plate over time to compensate for different locks on the door, or movement of the door jamb over time. |
| US10544598B2 |
Apparatus for grinding a concrete floor surface
An apparatus for grinding a concrete floor surface, in order to perform grinding with a manual, a pullable or a ride-on concrete trowel machine is provided. The apparatus comprises a concrete trowel organ to be used with the concrete trowel machine and a diamond grinding arrangement, such as one or several diamond disks or like, to be coupled in connection with the concrete trowel organ removably by means of a fastening arrangement. The fastening arrangement for coupling the diamond grinding arrangement in connection with the concrete trowel organ comprises a fastening frame, being in connection with the diamond grinding arrangement that exits on a scrubbing surface of the concrete trowel organ, and a fastening part extending from the fastening frame and, while going through the concrete trowel organ, getting supported against a back surface of the same. |
| US10544597B2 |
Tool attachment for raking mortar joints
An apparatus configured to be mounted to a power tool includes a hollow shaft configured to surround an operating element of the power tool; a substantially flat sled, in which a bottom surface of the sled is configured to interface with a working surface; and a guidance fin protruding from the bottom surface of the sled, wherein the guidance fin is configured to guide the apparatus along an operating path. The apparatus may include at least one vacuum port attachment, which can be mounted to a top surface of the sled and/or may be built into a support member of the apparatus. The apparatus may include a clamp configured to mount the apparatus to the power tool. The power tool can be a rotary hammer drill. |
| US10544594B2 |
Self-spacing lap siding product
A lap siding product with a unique shiplap joint that spaces abutting pieces of siding correctly from each other without installer measurements. The shiplap joint comprises a bottom element and a top element. A lap siding panel or board has a bottom element shiplap joint at one end, and a top elements shiplap joint at the other end. The corresponding ends of two lap siding panels or boards (i.e., one bottom element and one top element) together form the unique shiplap joint of the present invention. An engineered “stop” on the underside of the top element spaces the pieces of siding correctly, without requiring measurement during installation. This also eliminates the need for caulk, pan flashing or joint covers in the joint between the pieces of siding or cladding. The shape of the joint also reduces the intrusion of water, and re-directs water down and out from behind the siding. |
| US10544586B1 |
Ceiling system
A ceiling system with a plurality of T-bars attached to structural members defining a roof of a building; a plurality of clips having two ears depending upwardly from an upper horizontal member, a back wall depending downwardly from the upper horizontal surface and a panel engaging member connected to the back wall; a plurality of panels having a generally rectangular shape, an outward facing surface with microperforations thereon, and a slit on the major edge, wherein the panel engagement member of the clip is completely received within the slit and the back wall of the clip abuts an edge of the panel; and wherein the ears of the clip engage with the edges of a T-bar and secure the clip to the T-bar, and wherein each panel is attached by the clips to at least two T-bars. |
| US10544584B2 |
Wall connection system
A wall connection system is disclosed, which includes a horizontal building frame component with a first vertical face that has a first slot. The system further includes a prefabricated wall structure with a plurality of parallel studs and an elongate member connect to each stud. The elongate member has a second vertical face with a second slot and is parallel to the first vertical face. The long axis of the first slot is perpendicular to the long axis of the second slot. A fastener assembly connects the horizontal building frame component to the wall structure, through the slots. |
| US10544579B2 |
Construction panels, materials, systems, and methods
Construction panels and other materials, methods for their manufacture, and systems and methods for monitoring environmental conditions with such panels are provided herein. The panels include a core having a first surface and an opposed second surface, and an environmental sensor assembly associated with the panel and configured to detect an environmental condition of the panel and wirelessly communicate data on the environmental condition to a reader. |
| US10544571B2 |
Electronic faucet with spatial orientation control system
A faucet is provided that electronically controls the flow volume and temperature of water being dispensed. The faucet illustratively includes a faucet body and a faucet handle. The faucet illustratively includes an inertial motion unit sensor mounted in the faucet handle to sense spatial orientation of the faucet handle. The faucet illustratively includes an electronic flow control system to adjust flow volume and temperature of water being dispensed. The faucet illustratively includes a controller configured to receive signals from the inertial motion unit sensor and control the electronic flow control system to adjust flow volume and temperature of water being dispensed based upon the position of the faucet handle. |
| US10544568B2 |
Retainer sleeve for ground engaging tools
A retainer sleeve configured for use in a retainer system for a ground engaging tool includes a plurality of plate-like sections, each section being flexibly joined with an adjacent section along either a radially inner edge or a portion of a radially outer edge. The radially inner edges of the plurality of sections form part of a segmented inner surface configured for engagement with an outer surface of a locking member of the retainer system. The inner surface extends partially around a central axis of the retainer sleeve to form a substantially C-shaped retainer sleeve having opposite circumferential ends that are spaced from each other. The radially outer edges of the plurality of sections form part of a segmented, frustoconical outer surface configured for engagement in an internal lock cavity of a ground engaging tool tip. |
| US10544567B2 |
Method and system for monitoring a rotatable implement of a machine
A method, for monitoring an implement of a machine, includes receiving implement parameters associated with the implement and determining a range of movement of the implement based on the implement parameters. The method detects whether at least one object is located within the range of movement of the implement and displays a visual representation of the range of movement with a visual indication indicative of whether the at least one object is located within the range of movement. The method detects changes to the implement parameters and determines an updated range of movement based on the detected changes. Further, the method determines whether at least one object is located within the updated range of movement and displays a visual representation of the updated range of movement with an updated visual indication indicative of whether the at least one object is located within the updated range of movement. |
| US10544564B2 |
Shovel-type construction machine
The present invention aims to improve the strength of the portion of the swing frame for attaching the swing motor apparatus while reducing cost. A bottom plate of a swing frame is divided into a center bottom plate segment to which the swing motor apparatus mounting portion is attached, a front bottom plate segment that is positioned to the front side of the center bottom plate segment and to which the center joint mounting portion is attached, and a rear bottom plate segment positioned to the rear side of the center bottom plate segment, wherein: the center, front, and rear bottom plate segments and are formed integrally by welding; and the plate thickness of the center bottom plate segment is thicker than the plate thickness of the front bottom plate segment and the rear bottom plate segment. |
| US10544563B1 |
Spring loaded feeding device
A spring-loaded feeding device for a ditch digging apparatus. The spring-loaded feeding device includes a shaft rotatably mountable on a frame and rotatable in a direction of rotation, and one or more feeder paddle assemblies. each feeder paddle assembly comprises a bracket on the shaft extending radially outward, the bracket comprising a pivot axis proximate the shaft and a spring-connection point spaced apart from the pivot axis. The feeder paddle assembly also has a feeder paddle with a first end near the shaft and a second end spaced apart from the first end, the feeder paddle extending radially outward from the shaft from the first end to the second end, the feeder paddle being pivotally coupled to the bracket at the pivot axis and also coupled to the bracket by a spring positioned between the feeder paddle and the spring-connection point of the bracket. |
| US10544561B2 |
Collector assembly
A collector assembly for collecting debris from opposite sides of a member such as an elevated beam. The collector assembly includes a platform extending laterally between a first side edge and a second side edge. A first trough is provided for disposition along one side of the beam for receiving debris. A second trough is provided for disposition along the opposite side of the beam and is adjacent to and parallel with the first trough. |
| US10544560B2 |
Self cleaning bucket assembly for a digging machine
A bucket assembly for mounting on a boom of a digging machine comprises a bucket with an outer wall and a rear wall pivotally mounted between side walls of the bucket so that the rear wall is movable relative to the outer wall for discharging material from the bucket. In one arrangement this relative movement is provided by a linkage assembly which displaces the rear wall forwardly as the remainder of the bucket continues to move rearwardly to a retracted position of the bucket. In another arrangement the relative movement is provided by at least one stopper fixed in relation to the boom arranged for engaging the pivotal rear wall in an angularly intermediate position of the bucket such that the rear wall moves forwardly relative to the outer wall as the bucket moves rearwardly to its retracted position. |
| US10544553B1 |
Surface marking assembly
A surface marking assembly for providing guidance to vehicle operators includes first and second panels. The first panel is configured to couple to a surface, such as tarmac of a road. A plurality of solar cells is coupled to a top of the first panel. At least one battery is coupled to the first panel and is operationally coupled to the solar cells, which are configured to charge the battery. A plurality of bulbs is coupled to the first panel and is operationally coupled to the battery. The second panel, which is textured and substantially transparent, is coupled to the first panel to protect the solar cells and the bulbs. The battery is positioned to power the bulbs to provide visual direction to an operator of a vehicle proximate to the first panel. The second panel is configured to provide vibratory and auditory notifications to the operator. |
| US10544552B2 |
Wire mesh
A wire netting, in particular a safety net, has a plurality of helices which are braided with one another and at least one of which is manufactured of at least one single wire, a wire bundle, a wire strand, a wire rope and/or another longitudinal element with at least one wire, made of a high-tensile steel, and which includes a plurality of legs, which has a plurality of bending regions respectively connecting two legs, and which has a transverse extension along a frontal direction, perpendicularly to a main extension plane of the helix, wherein, in a press test between parallel plates, including a pressing by moving the plates along a press path in parallel to the frontal direction, a test piece of the helix, taken from the helix and including at least five legs and at least four bending regions, shows a spring characteristic curve which has in a press path force diagram, starting from a start of the press path, a first partial characteristic curve extending at least approximately linearly and having a first gradient. |
| US10544549B2 |
Athletic field safety border
A border member for establishing a border around a synthetic turf field comprises: an elongated body molded from a flexible material; at least one notch formed in an upper surface of the elongated body and extending along a length of the elongated body; and a rigid spine embedded within the elongated body and extending along the length of the elongated body. The border member is positioned adjacent to the synthetic turf field such that a portion of synthetic turf of the synthetic turf field rests on the notch. |
| US10544547B2 |
Disposable towel produced with large volume surface depressions
A disposable tissue or paper towel product including at least two plies, an exposed outer surface of at least one of the two plies comprising a plurality of pockets, the plurality of pockets having an average volume greater than 0.4 mm3 and an average surface area of 2.5 mm2. |
| US10544544B2 |
Process for the deinking of coated paper or paperboard
A process for the deinking of a coated paper or paperboard is disclosed, the process comprises a step of providing a coating layer comprising a calcium- or magnesium-exchanged clay which is deposited on the paper or paperboard before the ink layer. In a further step said calcium- or magnesium-exchanged clay is activated and the paper is subsequently treated with water. |
| US10544543B2 |
Garment incorporating aqueous polyurethane dispersions having altered stress profile
Articles, such as garments, including films comprising dried aqueous polyurethane dispersions are disclosed, whereby the garment has an altered stress which is exhibited during wear of the garment. The film may be bonded to the fabric of the article to provide a fabric or film laminate. |
| US10544539B2 |
Heat exchanger filter for self lint cleaning system in dryer appliance
A laundry appliance includes a rotating drum for processing laundry. A blower directs process air through an airflow path that includes the rotating drum. A heat exchanger is positioned within the airflow path that dehumidifies the process air. A fixedly-secured lint filter captures lint from the process air at a position upstream of the heat exchanger. A fluid spray system has spray nozzles that deliver fluid to a surface of the fixedly-secured lint filter. Each spray nozzle of the plurality of spray nozzles directs captured lint away from the fixedly-secured lint filter. |
| US10544538B2 |
Fabric treating appliance comprising a scrubbing tool
A fabric treating appliance includes a cabinet defining an interior and having a top wall defining an access opening. A cover is provided that is movable relative to the cabinet between an open position and a closed position to selectively close the access opening. A tub is located within the interior and includes and open top aligned with the access opening. A rotatable basket is located within the tub and has a loading opening aligned with the open top and the access opening. A top wall extends between the cabinet and the tub. |
| US10544534B2 |
Bottom foot of washing machine with automatic weighing structure
A washer bottom foot is installed below a base of a washing machine and has a weighing sensor. A cavity with a downward opening is provided in the bottom foot, and the weighing sensor is installed in the cavity in a closed manner. The bottom foot comprises a connecting portion and a supporting portion, which form an integrated convex structure, wherein the connecting portion is hollow axially, the supporting portion is provided below the connecting portion, and the cavity is provided in the supporting portion and communicates with a hollow portion of the connecting portion. The supporting piece comprises a supporting unit and a fixing unit, an upper end face of the supporting unit being in contact with the weighing sensor, and a lower end face being supported on the ground. |
| US10544530B2 |
Sheet manufacturing apparatus and sheet manufacturing method
There is provided a sheet manufacturing apparatus, including: a supplying unit configured to supply a cut-form material including fibers; a detection unit configured to detect information related to a weight of the material which is processed to be supplied by the supplying unit; a defibrating unit configured to defibrate the material; and a forming unit configured to form a sheet by using at least a part of a defibrated material defibrated by the defibrating unit, in which a supply interval of at least one material among a plurality of materials to be supplied later increases in a case where the weight of the material which is supplied at a unit time is heavy rather than in a case where the weight is light. |
| US10544529B2 |
Method and system for managing and controlling the feeding of at least one thread to a textile machine as a function of the operating step of the latter
Method and system for managing and controlling feeding of at least one thread to a textile machine as a function of the machine operating step in product production or thread processing, such production or processing providing for a succession of steps corresponding to obtaining product parts or treating thread. The thread fed to the machine by a feeder at constant tension and/or speed and/or controlled by a sensor which monitors sliding or inherent characteristic thereof such as tension, speed, diameter, quantity and color. The sensor and/or feeder controlled by a setting controller. The setting controller receiving synchronization signals from the machine and detecting—according to the latter—the operating steps and thus product or production status. The operation setting programmed as a function of operating steps. The machine generates a unique synchronization signal, for each operating step, independently from step length. |
| US10544528B2 |
Textile constructs formed with fusible filaments
A textile construct with a performance film formative built into a textile structure. The textile construct needs only to be subject to a fusing agent to cause the performance film formative to convert from its lattice structure (e.g., knit or woven structure) into a film that is built into a retained lattice structure of the textile. More particularly, the formation of the textile construct is based on fusion of selected filaments, e.g., thermoplastic fibers or yarns, to selectively create a film on one side or layer in the construct while substantially preserving the lattice structure of an opposing side or adjacent layer of non-fusible filaments in a lattice structure. This creates a hybrid film/lattice textile construct. Both open-faced and sandwiched constructions of the film in a unitary structure with the retained lattice structure of another side or layer(s) are possible. |
| US10544526B2 |
Obtaining emerized fabric properties by without applying sueding process to woven fabric with cotton yarn
A woven fabric is provided wherein pile weft yarns, auxiliary weft yarns, and warp yarns are weaved in the front face and back face of the fabric according to a pattern, and wherein at least one of the pile weft yarns and/or auxiliary pile yarns is synthetic elastomeric yarn and at least one of the same is cotton core-spun elastomeric yarn. |
| US10544523B2 |
Device for keeping an inaccessible element to be stabilised stationary in a required angular position and use of the device in a machine for processing textile threads
At least two pairs of magnets are arranged near one another on supports, the pairs of magnets and the supports form, when an item to be stabilized is in a required angular position, a closed magnetic circuit (except for the air gap), with magnets placed in such a direction that their north and south poles successively alternate with one another along the magnetic circuit, an item, sensitive to the magnetic field, is attached to the fixed part and placed inside the closed magnetic circuit, the sensitive item supplies a logic output state corresponding to the “item to be stabilized in the required angular position” when the detected field is less than a predetermined maximum threshold, and a logic state corresponding to the “item to be stabilized not in the required angular position”, when the detected field is greater than a minimum predetermined threshold. |
| US10544518B2 |
Chamber components for epitaxial growth apparatus
Chamber components for an epitaxial growth apparatus are disclosed. A reaction chamber defined and formed by a ceiling plate. A reactant gas is rectified in a reactant gas supply path disposed in the side wall, so that a horizontal component in a flow direction of the reactant gas in the reaction chamber corresponds to a horizontal component in a direction extending from the center of an opening of the reactant gas supply path. Improvements to the upper side wall, susceptor and rectification plate of the epitaxial growth apparatus have resulted in improvements to the uniformity and formation speed of the epitaxial layer formed on substrates resulting in higher throughput and lower defects. |
| US10544516B2 |
Flexible color adjustment for dark Cr(III) platings
The invention relates to a method for the adjustment of the lightness L* of electrolytically deposited chromium-finishes on workpieces obtained by an electroplating bath comprising at least chromium(III)-ions and sulfur containing organic compounds, wherein the concentration of the sulfur containing organic compounds in the bath are adjusted by passing at least part of the bath composition through an activated carbon filter. Furthermore, the invention is directed to dark chrome coatings comprising a defined concentration gradient of deposited sulfur containing organic compounds. |
| US10544513B2 |
Electrochemical reaction device
An electrochemical reaction device includes: a first electrolytic solution tank having a first storage part and a second storage part; a second electrolytic solution tank having a third storage part and a fourth storage part; a first reduction electrode layer immersed in a first electrolytic solution; a first oxidation electrode layer immersed in a second electrolytic solution; a first generator electrically connected to the first reduction electrode and the first oxidation electrode layer; a second reduction electrode layer immersed in a third electrolytic solution; a second oxidation electrode layer immersed in a fourth electrolytic solution; a second generator electrically connected to the second reduction electrode and the second oxidation electrode layer; and at least one flow path out of a first flow path connecting the first storage part and the fourth storage part and a second flow path connecting the second storage part and the third storage part. |
| US10544507B2 |
Film forming apparatus
A film forming apparatus (10) includes a mask body (34) configured to expose inner surfaces (14a) of cylinder bores (14), and mask an inner surface (16a) of a crankcase (16). The mask body (34) includes a main body portion (104), a sealing member (106) and a biasing member (108). The main body portion (104) is configured to stretch and contract, and includes a first tubular member (100) and a second tubular member (102) configured to have an insert structure at least part of which is slidable along an axial direction. The main body portion (104) can stretch and contact in a state where at least one end in the axial direction thereof contacts an inner surface of a cylinder block (12). The sealing member (106) is interposed between sliding surfaces of the first tubular member (100) and the second tubular member (102). The biasing member (108) is configured to resiliently bias the first tubular member (100) and the second tubular member (102) in a stretching direction of the main body portion (104). |
| US10544505B2 |
Deposition or treatment of diamond-like carbon in a plasma reactor
A method of performing deposition of diamond-like carbon on a workpiece in a chamber includes supporting the workpiece in the chamber facing an upper electrode suspended from a ceiling of the chamber, introducing a hydrocarbon gas into the chamber, and applying first RF power at a first frequency to the upper electrode that generates a plasma in the chamber and produces a deposition of diamond-like carbon on the workpiece. Applying the RF power generates an electron beam from the upper electrode toward the workpiece to enhance ionization of the hydrocarbon gas. |
| US10544503B2 |
Method of producing graphene
Graphene can be produced from the byproducts formed during electrolysis of coal. These byproducts may be electrolyzed coal particles, gelatinous film formed on the electrolyzed coal particles, or the electrolyzed coal particles together with the gelatinous film. The electrolyzed coal byproduct is deposited as a thin layer onto a surface, or carrier substrate 50, which is heated to a temperature effective to form graphite while a reductant gas, such as hydrogen, flows over the heated coal product. The reductant gas flow carries the carbon particles and deposits them onto a surface 66, forming a layer of graphene thereon. |
| US10544501B2 |
Multi-layer assembly and method for controlling layer thicknesses
A pre-fabricated assemblies and methods of use for coating substrates are described. The pre-fabricated assembly includes at least two layers in a stack, each layer includes at least one raw material. The raw material in each layer may be a dielectric material. One type of stack has one outer layer as an exposed layer. One type of stack has an exposed portion with each layer, and a portion of all layers is exposed. In use, a stack in a pre-fabricated assembly is positioned in a vacuum chamber system and energy is delivered sequentially to the exposed layer, removing at least a portion of each exposed layer. Each layer becomes an exposed layer and is deposited on the substrate in a sequential manner. The pre-assembled raw material stack is used to fabricate a multi-layered coating, such as a multi-layered coating for an optical or ophthalmic article. |
| US10544500B2 |
Ion assisted deposition top coat of rare-earth oxide
A chamber component comprises a body, a first protective layer and a conformal second protective layer over the first protective layer. The first protective layer comprises a plasma resistant ceramic, has a thickness of greater than approximately 50 microns and comprises a plurality of cracks and pores. The conformal second protective layer comprises a plasma resistant rare earth oxide, has a thickness of less than 50 microns, has a porosity of less than 1%, and seals the plurality of cracks and pores of the first protective layer. |
| US10544495B2 |
Casting mold material and Cu—Cr—Zr alloy material
A casting mold material of the present invention includes, as a composition: 0.3 mass % to less than 0.5 mass % of Cr, 0.01 mass % to 0.15 mass % of Zr, and a balance consisting of Cu and inevitable impurities, and the casting mold material has acicular precipitates or plate-like precipitates containing Cr. |
| US10544494B2 |
High-strength 6000-based alloy thick plate having uniform strength in plate thickness direction and method for manufacturing the same
The present invention relates to a high-strength aluminum alloy thick plate composed of an aluminum alloy including a prescribed quantity of Si, Mg, Ti, Fe, and the balance Al. The thick plate has a material structure in which an area ratio of Mg2Si having circle equivalent diameters of 3 μm or more in a plate thickness central portion is 0.45% or less; and an area ratio of Mg2Si having circle equivalent diameters of 3 μm or more in a region of 20 mm±1.5 mm from a plate surface in a plate thickness direction is 1.2 times or more and 3.0 times or less the area ratio of Mg2Si having circle equivalent diameters of 3 μm or more in the plate thickness central portion. The aluminum alloy thick plate has sufficient strength and good uniformity of strength in the plate thickness direction, and can be manufactured by cooling it after a solution treatment, so that suitable temperature difference occurs between a plate thickness central portion and a surface, and then performing a quenching treatment. |
| US10544487B2 |
Age-hardenable magnesium alloys
The subject invention provides compositions of a family of magnesium alloys for various applications including but not limited to automotive, aerospace, and biomedical applications. Preferred embodiments provide that this family of alloys comprises elements readily available domestically while offering improved mechanical properties at approximately half the cost of similar commercial alloys that comprise rare earth (RE) elements. Advantageously, utilization of these new magnesium alloys in car engine parts would lead to better fuel economy and in turn, reduce carbon dioxide emissions and environmental damages from vehicles. |
| US10544485B2 |
Additive manufacturing of high-temperature components from TiAl
Disclosed is a process for producing a component from a TiAl alloy by layer-by-layer deposition of powder on a substrate and/or an already produced semifinished product. The component has a proportion of x at % of aluminum which is in the range from about 34 to about 47 at % of aluminum, the powder having a proportion of x+1 at % to x+6 at % of aluminum. Also disclosed is a component formed from a TiAl alloy which has been produced by a corresponding process. |
| US10544480B2 |
Agglomeration drum for pre-treating minerals
The present invention refers to an agglomeration drum and to a procedure for the agglomeration of mineral inside said drum for the pretreatment of minerals, both of them mainly used in hydrometallurgy. Said drum and procedure use a system and a phase of recirculation of gases as part of the invention. Additionally, in the agglomeration procedure the process of chemical reactions occurring inside the agglomeration drum is included. The agglomeration drum, agglomeration procedure and the reactive process allow to obtaining uniform, stable and poorly degradable agglomerates that have a bigger agglomerate-reagent contact surface. The agglomerates or aggregates produced in the agglomeration drum and according to the process of the invention increase the extractive yield of the later leaching process, thus reducing the creation of preferred ways for the leaching solution in the leaching piles. In addition, the drum and procedure of the invention allow preventing the release of gases to the environment, having a gas recirculation system, which by being closed keeps gases inside the agglomeration drum and process. This recirculation of gases not only allows preventing the release of said gases to the environment, but it also reduces the operating costs by using the recirculated gases as part of the agglomeration process. |
| US10544477B2 |
Method for manufacturing high-strength galvanized steel sheet
A method for manufacturing a high-strength galvanized steel sheet includes performing hot rolling, cold rolling, first annealing, pickling, and second annealing. The first annealing is performed to obtain a steel sheet having a steel microstructure including ferrite in an amount of 10% or more and 60% or less in terms of area ratio, and martensite, bainite, and retained austenite in a total amount of 40% or more and 90% or less in terms of area ratio. The second annealing includes heating to an annealing temperature of 750° C. or higher and 850° C. or lower, holding at the annealing temperature for 10 seconds or more and 500 seconds or less, cooling at an average cooling rate of 1° C./s or more and 15° C./s or less, performing a galvanizing treatment, and cooling to a temperature of 150° C. or lower at an average cooling rate of 5° C./s or more and 100° C./s or less. |
| US10544472B2 |
Multiplexing transcription factor reporter protein assay process and system
A protein reporter system comprising at least one reporter including a response element responsive to the binding of a transcription factor, a secreted enzyme backbone and a recognition region for specific binding of an antibody. Multiplexed assays for binding, assaying and quantifying the activity of transcription factors are also described, in which the assays use protein reporters in sets, libraries or other groupings, as necessary to achieve desired quantification. |
| US10544469B2 |
Methods and compositions for producing capsicum plants with powdery mildew resistance
The invention relates to pepper plants and lines having resistance to Powdery Mildew, caused by the fungus Leveillula taurica. The invention also relates to parts of pepper plants from lines having Powdery Mildew resistance, including seeds capable of growing pepper plants with Powdery Mildew resistance, and fruit. Methods for the identification, use and breeding of Powdery Mildew resistant pepper plants are also provided. |
| US10544467B2 |
Solid tumor methylation markers and uses thereof
Disclosed herein are methods and kits for identifying a subject as having esophagus cancer, pancreatic cancer, or stomach cancer. Also provided herein are methods and kits for generating the methylation profile of a biomarker associated with esophagus cancer, pancreatic cancer, or stomach cancer. |
| US10544466B2 |
Method for diagnosing and treating cancer brain metastasis and drug delivery system for enabling passage through blood-brain barrier
A method increases permeability of a blood-brain barrier in a subject. The method includes administering a small interfering ribonucleic acid (siRNA) against the 3-Phosphoinositide Dependent Protein Kinase 1 (PDPK1) gene or micro ribonucleic acid (miRNA) miR-181c as an active ingredient to the subject. The method can be applied for delivering a desired active agent to the subject. |
| US10544465B2 |
NRAS assay
The present invention relates to methods and tool for amplification and detection of different NRAS isotypes. |
| US10544464B2 |
TERT promoter mutations in cancer
The present invention relates to the field of cancer. More specifically, the present invention provides methods and compositions related to certain promoter mutations in cancer. In one embodiment, a method for treating a subject having thyroid cancer comprises the steps of (a) obtaining a biological sample from the subject; (b) performing an assay on the sample obtained from the subject to identify a mutation at 1 295 228 C>T (C228T) and 1 295 250 C>T (C250T), corresponding to −124 C>T and −146 C>T from the translation start site in the promoter of the telomerase reverse transcriptase (TERT) gene; (c) identifying the subject as having or likely to develop aggressive thyroid cancer if the C228T and/or C250T mutation is identified; and (d) treating the subject with one or more treatment modalities appropriate for a subject having or likely to develop aggressive thyroid cancer. |
| US10544463B2 |
Methods for assessing risk of developing a viral disease using a genetic test
This document provides methods and materials related to treating a disease. For example, this document provides methods for treating a subject's disease based on identifying the risk of progressive multifocal leukoencephalopathy PML using a genetic test. |
| US10544462B2 |
Biomarkers predictive of predisposition to depression and response to treatment
The present invention relates generally to the identification of subjects with a predisposition to recurrent depression, predicting a subject's responsiveness to therapy, and determining whether a subject has remitted from depression following therapy. In particular, provided herein are biomarkers, methods, and kits for such uses. |
| US10544460B2 |
Homeobox transcription factor ventx regulates differentiation and maturation of human dendritic cells
The invention relates to human homeobox transcription factor VentX and its regulation of differentiation and maturation of human dendritic cells, and related therapeutic and diagnostic compositions and methods of use. |
| US10544458B2 |
Device and method for detecting target molecules
The present invention relates to a microarray device for detecting a target molecule such as miRNA in a sample. The device comprises a carrier substrate such as glass, an anti-fouling polymer layer which is functionalised with N-Hydroxysuccinimide (NHS) or carboxyl-groups and a capture probe. In an embodiment, the capture probe is an oligonucleotide with a stem-loop structure. The invention further defines a method for fabricating the device, a kit for detecting the target nucleic acid molecule comprising the device and a detection probe. |
| US10544457B2 |
Methods and compositions for enriching compositions for polymerase enzyme complexes
The present invention provides methods, compositions, and systems for enriching compositions for polymerase enzyme complexes. In particular, the methods, compositions, and systems of the present invention remove free polymerases from the compositions using one or more purification steps, including protease treatment, thus enriching the compositions for polymerases complexed with a template nucleic acid. |
| US10544453B2 |
Method for detecting nucleic acid amplification product in real time
There is provided an apparatus for detecting a nucleic acid amplification product in real time, which is capable of effectively excluding or reducing apparatus error factors without using a second fluorescence signal used for correction. A plurality of wells 7A are given with temperature cycles and fluorescence strength from a nucleic acid amplification product is detected in real time in each well 7A. A fluorescence measurement value [DNA]raw obtained from the well 7A and a fluorescence measurement value [DNA]bg obtained from a connection wall near the well 7A are detected, and the fluorescence measurement value [DNA]bg is subtracted from the fluorescence measurement value [DNA]raw to determine fluorescence strength [DNA]real of the well 7A. |
| US10544444B2 |
Compositions for in situ labeling of bacterial cell walls with fluorophores and methods of use thereof
Disclosed herein are compositions for assessing peptidoglycan biosynthesis in bacteria, for identifying bacteria, and for screening for bacterial cell wall-acting and/or cell wall-disrupting agents via modified D-amino acids and methods of use thereof. Also disclosed are live bacteria having one or more modified D-amino acids as described herein incorporated into peptidoglycan of a bacterial cell wall. |
| US10544443B2 |
Detection of bacteria using bacteriophage
A method of detecting a species, strain or type of bacteria includes mixing a labeled bacteriophage including a label that is detectible via a detection system with a bacterial culture including the species, strain or type of bacteria to which the labeled bacteriophage selectively binds and using the detection system to detect the labeled bacteriophage bound to the species, strain or type of bacteria. |
| US10544442B2 |
Methods for the determination of biogenic gas
Provided are methods of estimating a volume of a biogenic gas for an area of interest. The method includes predicting a methanogenesis rate for one or more of the periods of time for the area of interest based on energy available for microbial activity and calculating the volume of the biogenic gas based on the predicted methanogenesis rate for the one or more of the periods of time for the area of interest. |
| US10544441B2 |
Method for biocatalytic whole cell reduction of dehydrocholic acid compounds, and 7-β-hydroxysteroid dehydrogenase mutants
The invention relates to novel biocatalytic processes comprising the whole cell reduction of dehydrocholic acid (DHCA) compounds, novel 7β-hydroxy steroid dehydrogenase mutants, the sequences coding for these enzyme mutants, methods for producing the enzyme mutants and use thereof in enzymatic conversions of cholic acid compounds, and in particular in the production of ursodesoxycholic acid (UDCA); also a subject of the invention are novel methods for the synthesis of UDCA using the enzyme mutants; and in particular a further improved method for producing UDCA using recombinant whole cell biocatalysts. |
| US10544439B2 |
Hexuronate C4-epimerase variant having improved D-tagatose conversion activity, and D-tagatose production method using same
Provided are a hexuronate C4-epimerase variant with improved activity in converting D-fructose by D-tagatose of hexuronate C4-epimerase and a method for production of D-tagatose using them. |
| US10544436B2 |
Compositions and methods for biological production of methionine
The present disclosure provides compositions and methods for using modified hydrogenotrophic microorganisms capable of biologically utilizing or converting CO and/or CO2 gas, optionally in the presence of H2, into methionine. |
| US10544435B2 |
L-ornithine production in eukaryotic cells
The present invention relates to the provision of genetically modified microbial cells, such as yeast cells with an improved ability for producing L-ornithine and its derivatives. Overproduction of L-ornithine is obtained in the first place by the down-regulation or attenuation of specially selected genes, wherein said genes encode enzymes involved in the L-ornithine consumption and/or degradation pathways. Further L-ornithine production ability is improved by down-regulation, attenuation, deletion or overexpression of specially selected genes, wherein said genes encode enzymes and/or proteins involved in the L-ornithine ‘acetylated derivatives cycle’, L-glutamate synthesis pathways, subcellular trafficking, TCA cycle, pyruvate carboxylation pathway, respiratory electron-transport chain, and the carbon substrates' assimilation machinery. The invention additionally provides a method to produce L-ornithine with said modified eukaryotic cells. |
| US10544434B2 |
Process for the preparation of lisdexamfetamine and related derivatives
The present invention is directed to processes for the preparation of lisdexamfetamine and related derivatives, wherein the processes comprise coupling to racemic or enantiomerically enriched amphetamine and wherein the resulting product is advantageously enantiomerically or diastereomerically enriched in the desired stereoisomer. |
| US10544424B2 |
Algal chloroplastic SRP54 mutants
Mutant photosynthetic microorganisms having reduced chlorophyll and increased photosynthetic efficiency are provided. The mutant strains have mutated chloroplastic SRP54 genes and exhibit increased productivity with respect to wild type strains. Also provided are mutant algal strains having mutated cytosolic SRP54 genes. Provided herein are methods of producing biomass and other products such as lipids using strains having mutations in an SRP54 gene. Also included are constructs and methods for attenuating or disrupting SRP54 genes. |
| US10544423B2 |
Recombinant promoter with increased fiber-specific expression
The present application discloses a recombinant fiber-selective promoter region comprising a DNA molecule comprising a fiber specificity region of a cotton lipid transfer protein gene promoter, operably linked to a DNA molecule comprising a nucleotide sequence having at least 90% sequence identity to a nucleotide sequence of about 500 consecutive nucleotides of the 3′ end of the FB8-like 2 promoter and use thereof to increase fiber-selective expression of products of interest in cotton fiber cells. |
| US10544418B2 |
RNAi inhibition of alpha-ENaC expression
The invention relates to compositions and methods for modulating the expression of alpha-ENaC, and more particularly to the downregulation of alpha-ENaC expression by chemically modified oligonucleotides. |
| US10544415B2 |
Methods for producing enteroendocrine cells that make and secrete insulin
Methods are described for producing enteroendocrine cells that make and secrete insulin in a mammal by blocking the expression or biological activity of one or more forkhead box O (Foxo) proteins or biologically active fragments or variants thereof. |
| US10544412B2 |
Directed evolution of multivalent glycopeptides that tightly bind to target proteins
The invention relates to a method for selecting a glycopolypeptide that binds to a target protein, the method including the steps of providing a pool of glycopolypeptides fused via puromycin linker to an encoding mRNA-cDNA duplex; combining the pool with a target protein to form a mixture; incubating the mixture for a period of time sufficient to allow any target protein to bind to one or more of the glycopolypeptides, thereby forming glycopolypeptide-target protein complexes; and isolating from the mixture the glycopolypeptide-target protein complexes, thereby identifying a plurality of selected glycopolypeptides. |
| US10544411B2 |
Methods for generating a glucose permease library and uses thereof
The present disclosure describes methods for generating microbial strains expressing a heterologous bacterial glucose permease gene that produce biomolecules of interest. In aspects, the disclosure provides novel bacterial strains, which express a heterologous bacterial glucose permease gene whose expression is controlled by a native Corynebacterium glutamicum promoter or a mutant promoter derived therefrom. Also provided herein are methods for producing a library of bacterial glucose permease genes using a promoter ladder comprising a plurality of promoters derived from Corynebacterium glutamicum. |
| US10544405B2 |
Cas9-nucleic acid complexes and uses related thereto
This disclosure relates to Cas9-nucleic acid complexes and uses related thereto. In certain embodiments, the disclosure contemplates transgenic plants and animals genetically engineered to express Cas9-nucleic acid complexes disclosed herein. In certain embodiments, the disclosure relates to methods of treating or preventing, diseases, conditions, cancer, viral infections or other pathogenic infection using vectors configured to express a Cas9-nucleic acid complex disclosed herein. |
| US10544395B2 |
Method of cell culture
A method of cell culture comprising providing cells in a cell culture medium to start a cell culture process, and, maintaining at least one metabolite selected from 3-(4-hydroxyphenyl)lactate, 4-hydroxyphenylpyruvate, phenyllactate, indolelactate, indolecarboxylic acid, homocysteine, 2-hydroxybutyric acid, isovalerate and formate below a concentration C1 in the cell culture medium, wherein C1 is 3 mM and/or (ii) maintaining at least one amino acid selected from phenylalanine, tyrosine, tryptophan, methionine, leucine, serine, threonine and glycine below a concentration C2 in the cell culture medium, wherein C2 is 2 mM. |
| US10544394B2 |
Method of increasing proliferation of bone marrow mononuclear cells expressing STRO1-dim
The present invention relates to methods of enhancing proliferation and/or survival of mesenchymal precursor cells (MPC) and/or progeny derived therefrom in vitro or in vivo comprising exposing the MPC or progeny to SDF-1 or analog thereof. The invention also relates to compositions comprising isolated MPCs or progeny derived therefrom and SDF-1 or analogues thereof. The present invention also relates to using such methods and compositions for ex vivo or in vivo bone formation in mammals. |
| US10544391B2 |
Methods for high throughput sperm sorting
This disclosure relates to methods for sorting sperm cells in a microfluidic chip. In particular, various steps are incorporated to align and orienting sperm in flow channels, as well as, to determining sperm orientation and measure relative DNA content for analysis and/or sorting. |
| US10544388B2 |
Methods for modulating osteochondral development using bioelectrical stimulation
Compositions and methods are provided for modulating the growth, development and repair of bone, cartilage or other connective tissue. Devices and stimulus waveforms are provided to differentially modulate the behavior of osteoblasts, chondrocytes and other connective tissue cells to promote proliferation, differentiation, matrix formation or mineralization for in vitro or in vivo applications. Continuous-mode and pulse-burst-mode stimulation of cells with charge-balanced signals may be used. Bone, cartilage and other connective tissue growth is stimulated in part by nitric oxide release through electrical stimulation and may be modulated through co-administration of NO donors and NO synthase inhibitors. Bone, cartilage and other connective tissue growth is stimulated in part by release of BMP-2 and BMP-7 in response to electrical stimulation to promote differentiation of cells. The methods and devices described are useful in promoting repair of bone fractures, cartilage and connective tissue repair as well as for engineering tissue for transplantation. |
| US10544386B2 |
Method for rapid maturation of distilled spirits using light and ultrasonic energy processes
An improved system and process for rapidly producing distilled spirits having characteristics associated with a much longer maturation process is provided. The method involves (a) subjecting an unmatured spirit to ultrasonic energy at a power of at least 3 Watts/Liter for at least one hour while maintaining the temperature of the unmatured spirit between 90° F. and 150° F.; and (b) subjecting the unmatured spirit and wood to actinic light at a wavelength ranging from 400 nm to 1000 nm for a cumulative exposure of at least 2,280,000 lux hours. The disclosure also provides embodiments where a spirit processed with ultrasonic energy is mixed with a spirit that has been separately treated with light to give characteristics of a mature spirit. |
| US10544374B2 |
Process for reducing haze in heavy base oil and hydroisomerization catalyst system having reduced haze
A process for reducing haze in a heavy base oil includes: obtaining a first effluent oil by contacting a hydrocarbon feedstock with a first catalyst including a zeolite of the ZSM-12 family; and obtaining a second effluent oil by contacting the first effluent oil with a second catalyst including a zeolite of the ZSM-48 family. A hydroisomerization catalyst system having reduced haze includes: a first catalytic region having a first catalyst disposed therein, the first catalyst including a zeolite of the ZSM-12 family; and a second catalytic region having a second catalyst disposed therein, the second catalyst including a zeolite of the ZSM-48 family. The first catalytic region is disposed upstream of the second catalytic region. |
| US10544373B2 |
Process for selectively allocating heating duty in a catalytic reforming system
A process for a catalytic reforming system, the process comprising controlling an amount of aromatic hydrocarbon fed to a sulfur removal system in the catalytic reforming system such that a temperature of a reduced sulfur stream flowing from the sulfur removal system is higher than a temperature of a stream which is fed to the sulfur removal system, due to a heat of reaction generated in the sulfur removal system by converting at least a portion of the aromatic hydrocarbon to aliphatic hydrocarbons. A process for a catalytic reforming system, the process comprising feeding an effective amount of aromatic hydrocarbons to a sulfur removal system of the catalytic reforming system such that a heat duty of a first furnace of a plurality of reactor-furnace pairs connected in series in the catalytic reforming system is reduced relative to operation of the sulfur removal system without the effective amount of aromatic hydrocarbons. |
| US10544372B2 |
Distillation tower for improving yield of petroleum hydrocarbon distillate and feeding method thereof
The present invention relates to a method for obtaining a fraction oil yield from petroleum hydrocarbons in a distillation column, wherein said distillation column comprises a fractionation stage, a vaporization section and a stripping stage from the top to the bottom of the distillation column. The method comprises preheating and sending a feedstock oil of petroleum hydrocarbons through a pressure-feeding system at a pressure of 100-1000 kPa higher than the vaporization section pressure of the distillation column, wherein said preheating is conducted in a heating furnace, wherein said heating furnace has an outlet pressure of 100-1000 kPa higher than the vaporization section absolute pressure, and an outlet temperature of 360-460° C. |
| US10544367B2 |
Char separator and method
The present invention relates to an apparatus and method for processing reusable fuel wherein the apparatus comprises a support body and a plurality of augers disposed within the support body. The augers may be configured to rotate against a vapor flow to clean carbon char from vapors comprising condensable and non-condensable hydrocarbons. A drive system may be connected to drive and control the plurality of augers. An exhaust system is connected to the support body. A gearbox housing is connected to the exhaust system, wherein the drive system is accommodated in the gearbox housing. A ventilation system is disposed within the gearbox housing. Additionally, a thermal expansion system may be connected to the support body. |
| US10544360B2 |
Materials for organic electroluminescent devices
The present invention relates to mixtures comprising at least one phosphorescent dopant and at least one compound of one of the formulae (1) and (2), and the use thereof in electronic devices, especially in organic electroluminescent devices. |
| US10544357B2 |
Y-Grade NGL stimulation fluids
Y-Grade NGL fracturing systems and methods of using Y-Grade NGL stimulation fluids. |
| US10544356B2 |
Inhibiting corrosion in a downhole environment
A method and system for inhibiting corrosion of a surface in a well including introducing a composition into the well, the composition comprising an acidic medium and Dihydrogen (ethyl) [4-[4-[ethyl(3-sulphonatobenzyl)amino] (4-hydroxy-2-sulphonatobenzhydrylidene]cyclohexa-2,5-dien-1-ylidene](3-sulphonatobenzyl)ammonium), contacting the metal surface with the composition, and inhibiting corrosion of the metal surface with the Dihydrogen (ethyl)[4-[4-[ethyl(3-sulphonatobenzyl)amino](4-hydroxy-2-sulphonatobenzhydrylidene]cyclohexa-2,5-dien-1-ylidene] (3-sulphonatobenzyl)ammonium). |
| US10544355B2 |
Methods and compositions for stimulating the production of hydrocarbons from subterranean formations using emulsions comprising terpene
Methods and compositions for stimulating of the production of hydrocarbons (e.g., formation crude oil and/or formation gas) from subterranean formations, and methods of selecting a composition for treating an oil or gas well. In some embodiments, the compositions are emulsions or microemulsions, which may include water, a terpene, and a surfactant. |
| US10544352B2 |
Conveyance of ambient-reactive subterranean formation additives to downhole locations
Methods including mixing a treatment fluid slurry in a storage tank, the treatment fluid slurry comprising an insulative base fluid, an ambient-reactive subterranean formation additive (ARA), wherein the ARA reacts at an ambient temperature, the reaction resulting in surface modification of the ARA, degradation of the ARA, or a combination of surface modification and degradation of the ARA, and wherein the insulative base fluid maintains the treatment fluid slurry at a temperature different from the ambient temperature to prevent the ARA from reacting; and introducing the treatment fluid slurry into a subterranean formation. |
| US10544350B2 |
Settable, form-filling loss circulation control compositions comprising in situ foamed non-hydraulic sorel cement systems and method of use
This document relates to settable, non-hydraulic foamed cement compositions comprising nitrogen gas-generating compositions used for loss circulation control. |
| US10544349B2 |
Cement with resilient latex polymer
Compositions comprising: (i) a hydraulic cement; and (ii) a polymer comprising at least one monomer having an oxazoline group. Methods of cementing in a well comprising: (A) forming a hydraulic cement composition comprising: (i) a hydraulic cement; (ii) a polymer comprising at least one monomer having an oxazoline group; and (iii) water; (B) introducing the hydraulic cement composition into the well. |
| US10544348B2 |
Biopolymer composite for water-based treatment fluids
An aqueous-based treatment fluid comprising: a base fluid, wherein the base fluid comprises water; and an additive, wherein the additive comprises a biopolymer matrix and a compound comprising a functional group containing nitrogen, A method of using the aqueous-based treatment fluid comprising: introducing the treatment fluid into a wellbore, wherein the wellbore penetrates a subterranean formation. |
| US10544346B2 |
Constitutionally dynamic polymer for treatment of subterranean formations
Various embodiments disclosed relate to constitutionally dynamic polymer for treatment of subterranean formations. In various embodiments, the present invention provides a method of treating a subterranean formation, the method including placing in the subterranean formation a composition including a constitutionally dynamic polymer. |
| US10544345B2 |
Flaky date fruit CAP for moderate to severe loss control
A lost circulation material (LCM) having date fruit caps is provided. The date fruit cap LCM includes date fruit caps from a date tree. The date fruit caps have multiple flakes (for example, three flakes) attached at one end to an end cap and free at the other end. The date fruit caps may be obtained from the waste product of date tree and date fruit processing. The date fruit cap LCM may be added to a drilling fluid (for example, a drilling mud) to mitigate or prevent such lost circulation in a well. Methods of lost circulation control with the date fruit cap LCM are also provided. |
| US10544344B2 |
Methods and systems for neutralizing hydrogen sulfide during drilling
A method to neutralize hydrogen sulfide in a wellbore during drilling operations is provided. The method comprising the steps of mixing an amount of scavenger into a drilling mud to produce a scavenger-containing drilling mud such that the scavenger-containing drilling mud has a scavenging capacity, wherein the drilling mud is at a target pH, and introducing the scavenger-containing drilling mud into the wellbore during drilling operations, where the scavenger-containing drilling mud is operable to work with a drill bit to drill the wellbore, where the amount of scavenger in the scavenger-containing drilling mud is operable to irreversibly react with hydrogen sulfide present in the drilling mud to produce a scavenged hydrogen sulfide. |
| US10544340B2 |
Brine generation system
A brine generation system includes a tank unit having a tank body and a divider which separates the tank into an upper portion for holding salt crystals and a lower portion for holding brine. The divider is adapted to resist the movement of salt crystals greater than a predetermined size and to permit the brine solution to pass from the upper portion through the divider to the lower portion by the effect of gravity. The divider includes a sump channel having an opening in communication with the upper portion of the tank unit. The sump channel is adapted to collect non-soluble particles greater than a predetermined size and permit the brine solution in the sump channel to pass therethrough to the lower portion of the tank unit. The sump channel is in communication with a sediment discharge port defined in the tank body. |
| US10544336B2 |
Composition for pressure-sensitive adhesive, pressure-sensitive adhesive resin tape, and wire harness
The present invention relates to a composition for a pressure-sensitive adhesive comprising 100 parts by mass (non-volatile fraction) of a main agent comprising a mixture of a natural rubber latex and a synthetic rubber latex, 40 to 120 parts by mass of a rosin-based tackifier resin having a softening point of 130 to 135° C. and 1 to 15 parts by mass of low-molecular-weight polyisoprene having a weight-average molecular weight of 15,000 to 40,000. |
| US10544328B2 |
Printed circuit board inks
The present invention provides a photoimageable composition comprising a polyamideimide resin, an aprotic solvent, and one or more nitrogen containing ethylenically unsaturated monomers. By addition of the nitrogen containing ethylenically unsaturated monomer, UV curable acrylates can be added to the composition, and the composition is stable. The compositions of the present invention can produce high resolution images that are flexible, hard, and have excellent resistance. |
| US10544327B2 |
Scratch-resistant aqueous 2K PU coatings
The invention relates to aqueous two-component coating compositions based on preferably hydroxy-functional and/or amino-functional aqueous polymer dispersions and thioallophanates containing silane groups as crosslinking agents, to a method for producing them and to the use of these coating compositions for producing coatings. |
| US10544323B2 |
Dry colour systems and methods and easily dispersible formulations for use in such systems and methods
A dry pigment paint system includes dry pigment doses that may be used alone or combined with other dry pigment doses to provide a desired color when dispersed in a paint base. The system may use a plurality of dry pigment formulations, with each dry pigment formulation consisting of one or more dry pigments, generally a plurality of dry pigments. Each dry pigment dose may include a single dry pigment formulation. Each does may be a tablet, capsule or sachet. Various dose forms and dispensing systems are disclosed. Formulations of easily dispersible (ED) pigments comprising a combination of a carboxylic acid polymer and a non-ionic alkoxylated surfactant are also disclosed. The combination is used in the formulation of a plurality of pigments. The formulations are suitable for mixing with a base medium at the point-of-sale (PoS) or by the end user. |
| US10544322B2 |
Method of preparing ink jet resin composition
The present invention provides a method of preparing an ink jet resin composition including preparing a liquid (a) including a thermosetting epoxy resin and a first non-volatile acryl compound, preparing a liquid (b) including a pigment and a second non-volatile acryl compound, preparing a liquid (c) including a photoinitiator and a third non-volatile acryl compound, and mixing the liquids (a), (b) and (c) and further including an amine synergist and a viscosity controlling agent to prepare a resin composition. According to the method of preparing an ink jet resin composition of the present invention, an ink jet resin composition may be easily prepared without using a volatile solvent but using acryl compounds as diluents, and the resin composition prepared thereby may have improved heat resistance, chemical resistance and adhesion. |
| US10544320B2 |
Ink composition, inkjet recording method, and colored article
An ink composition that offers a recorded image having rubfastness and having high quality without causing a mottling phenomenon, an inkjet recording method using the same, and a colored article. The ink composition includes a compound represented by the following formula (1): a colorant, a dispersant, and a C4-C12 alkanediol, in which the content of the compound represented by formula (1) is 0.1 to 5% by mass. In the formula (1), R1 represents a hydroxy group or the like, R2 represents an alkyl group or the like, R3 represents an alkyl group or the like, R4 represents a hydrogen atom or the like, and R5 represents an alkyl group. |
| US10544319B2 |
Inkjet printing ink
An inkjet printing ink according to the present disclosure contains a pigment, acrylic particles, an alcohol, and water. The alcohol contains at least a trihydric alcohol. A ratio of an amount of the alcohol to a whole mass of the inkjet printing ink is 30% by mass or less. A ratio of an amount of the acrylic particles to a mass of the pigment is 5% by mass to 100% by mass. Further, the inkjet printing ink has negative skin irritation. |
| US10544318B2 |
Inks
A black ink-jet printing ink comprising: a) from 9 to 11.5 parts of C.I. Reactive Black 39; b) from 5 to 7.5 parts of C.I. Reactive Brown 11 and/or C.I. Reactive Yellow 95; c) from 2.5 to 4 parts of C.I. Reactive Orange 12 and/or C.I. Reactive Orange 13; d) from 0.1 to 10 parts of a buffer; e) from 15 to 30 parts of ethylene glycol; f) from 0 to 10 parts of a water miscible solvent; g) from 0.01 to 2.5 parts of a non-ionic surfactant; h) from 4 to 14 parts of urea; i) from 0 to 5 parts of biocide; and j) the balance to 100 parts water. Also an ink-jet printing process, a multicolour ink-set and printed substrates. |
| US10544314B2 |
Composition for solar cell electrodes and electrode fabricated using the same
A composition for solar cell electrodes and a solar cell electrode fabricated using the composition, the composition including a conductive powder; a glass frit; an organic vehicle; and a surface tension modifier, wherein the surface tension modifier has a surface tension of about 40 mN/m to about 65 mN/m, and the composition has a thixotropic index (TI) of about 3 to about 10 as represented by Equation 1: TI=(viscosity at 10 rpm/viscosity at 100 rpm), [Equation 1] in Equation 1, the thixotropic index is calculated using viscosity values of the composition measured at 10 rpm and 100 rpm and at 23° C. with a No. 14 Spindle using a rotary viscometer. |
| US10544306B2 |
Sol-gel compositions with improved hardness and impact resistance
The present disclosure provides a hybrid coating composition including a siloxane-based polymer and an organic polymer. The composition can be applied to a wide variety of substrates include metals, ceramic materials, plastics, composites, minerals and the like. A process for making articles is also provided. |
| US10544302B2 |
Polycarbonate and liquid crystal polymer blends
The disclosure concerns a polymer blend derived from transesterification of (i) 69.9 to 95 weight percent polycarbonate; and (ii) 4.9 to 30 weight percent liquid crystal polymer; in the presence of 0.01 to 0.1 weight percent catalyst; wherein the polymer is transparent. |
| US10544298B2 |
High-rigidity rubber composition
A rubber composition comprises at least one phenol/aldehyde resin based on at least one aromatic polyphenol comprising at least one aromatic ring bearing at least two hydroxyl functions in the meta position relative to one another, the two positions ortho to at least one of the hydroxyl functions being unsubstituted, and at least one aromatic polyaldehyde selected from 1,3-benzenedicarboxaldehyde, 1,4-benzenedicarboxaldehyde and mixtures of these compounds, the rubber composition having a nominal secant modulus at 10% elongation, measured according to standard ASTM D 412, 1998, of greater than or equal to 25 MPa. |
| US10544297B2 |
Fiber reinforced polymer composition
The present invention refers to a fiber reinforced polymer composition comprising a polypropylene, carbon fibers, fibers other than carbon fibers and a polar modified polypropylene as coupling agent as well as to an article comprising the fiber reinforced polymer composition. |
| US10544295B2 |
Covering materials for adhesive hot-melt glues
The invention relates to a nontacky film-forming polymer composition (cover material), and tacky hot melt adhesives in the form of pellets which are coated with the polymer composition and producible by coextruding the hot melt adhesive and the cover material. The film-forming composition comprises 5 to 40% by weight of at least one Fischer-Tropsch wax having a melting point of >95° C. and 30 to 70% by weight of at least one metallocene-catalyzed polyolefin having a softening point of >95° C. and a melt flow index (MFI) (230° C., 2.16 kg) of ≤1000 and ≥300 g/10 minutes. The invention further relates to suitable uses for such hot melt adhesives, methods for their use, and products containing these adhesives. |
| US10544288B2 |
Pneumatic tire
The present invention is directed to a pneumatic tire having a tread comprising a vulcanizable rubber composition comprising, based on 100 parts by weight of elastomer (phr), (A) from about 60 to about 40 phr of a solution polymerized styrene-butadiene rubber having a glass transition temperature (Tg) ranging from −85° C. to −50° C.; (B) from about 40 to about 60 phr of natural rubber; and (C) from about 5 to 40 phr of a process oil; (D) optionally, from about 5 to 15 phr of a hydrocarbon traction resin (E) from 60 to 90 phr of silica; wherein the weight ratio of silica to the sum of the amounts of oil and traction resin is greater than 2.2. |
| US10544287B2 |
Rubber composition for tire
The rubber composition of the present invention is prepared by mixing a rubber component (A), zinc oxide (B), and a co-condensate (C) having a softening point of 150° C. or lower and containing a p-tert-butylphenol-derived constituent unit represented by the following formula (1), an o-phenylphenol-derived constituent unit represented by the following formula (2) and a resorcinol-derived constituent unit represented by the following formula (3), wherein the nitrogen adsorption specific surface area (N2SA) of the zinc oxide (B) measured according to the BET method is 6 m2/g or more and 110 m2/g or less, the mixing amount of the zinc oxide (B) is 5 parts by mass or more and 13 parts by mass or less based on 100 parts by mass of the rubber component (A), and the mixing amount of the co-condensate (C) is 0.1 parts by mass or more and 10 parts by mass or less based on 100 parts by mass of the rubber component (A). The co-condensate (C) is usable as a replacement for p-tert-octylphenol and p-nonylphenol, has a softening point lower than the maximum temperature in a rubber processing step, and has excellent dispersibility in rubber. |
| US10544281B2 |
Addition-curable silicone rubber composition and cured product
Provided is an addition-curable silicone rubber composition containing (A) an alkenyl group-containing organopolysiloxane having alkenyl groups bonded to at least two silicon atoms per molecule, (B) an organohydrogenpolysiloxane containing hydrogen atoms bonded to at least two silicon atoms per molecule, (C) a platinum catalyst, and (D) a benzotriazole derivative represented by general formula (I) (in the formula, R1 is a hydrogen atom or monovalent hydrocarbon group, R2 is a monovalent organic group) that makes it possible to provide silicone rubber that can lower the compression set without harming the curing rate and suppress discoloration after a heat resistance test. |
| US10544280B1 |
Joining compositions and methods
Disclosed are joining compositions that are suitable for use as adhesives or sealants in various embodiments. Generally, the compositions include silyl-modified polyether polymers in combination with dibenzoate plasticizers. When used as sealant compositions, the joining compositions can exhibit improved stability and reduced leaching of plasticizer components. When used as adhesives, the joining compositions can be used in numerous applications including residential and commercial building applications. Methods of manufacture and use of the compositions are also disclosed. |
| US10544278B2 |
Thermoplastic resin composition and article produced therefrom
A thermoplastic resin composition and a molded article produced therefrom. The thermoplastic resin composition includes about 100 parts by weight of a thermoplastic resin and about 0.5 to about 30 parts by weight of zinc oxide. The zinc oxide has a peak intensity ratio (B/A) of about 0.01 to less than about 0.1, where A indicates a peak in the wavelength range of 370 nm to 390 nm and B indicates a peak in the wavelength range of 450 nm to 600 nm in photoluminescence measurement. The thermoplastic resin composition can exhibit good properties in terms of deodorization, impact resistance, and the like. |
| US10544276B2 |
Process for the depolymerization of a polyester comprising opaque polyethylene terephthalate
A subject-matter of the invention is a process for the depolymerization of a polyester feedstock comprising opaque PET, the said process comprising at least the stages of conditioning, of depolymerization and of separation of the diol and of separation of the liquid effluent rich in monomers, followed by a decolouration stage. |
| US10544273B2 |
Dual component LLDPE copolymers with improved impact and tear resistance
Disclosed are ethylene polymer compositions containing a homogeneously-branched first ethylene polymer component and a homogeneously-branched second ethylene polymer component of higher density than the first ethylene polymer component. The ethylene polymer composition can be characterized by a density from 0.912 to 0.925 g/cm3, a melt index less than 3.5 g/10 min, and a CY-a parameter at 190° C. from 0.25 to 0.65. These polymer compositions have the excellent dart impact strength and optical properties of a metallocene-catalyzed LLDPE, but with improved machine direction tear resistance, and can be used in blown film and other end-use applications. |
| US10544270B2 |
Nanocellulose-reinforced cellulose fibers
Nanocellulose-reinforced cellulose fibers can increase the strength of hardwood fibers or agricultural-residue cellulose fibers, to simulate the strength of softwood fibers in pulp or pulp products (including composites). In some variations, the invention provides a method of reinforcing cellulose fibers, comprising providing cellulose fibers derived from hardwoods, agricultural residues, or a combination thereof; providing a source of nanocellulose comprising cellulose nanofibrils and/or cellulose nanocrystals; and reinforcing the cellulose fibers with the nanocellulose to increase strength of the cellulose fibers. In some embodiments, the nanocellulose is obtained from fractionating biomass in the presence of an acid, a solvent for lignin, and water, to generate cellulose-rich solids and a liquid phase; and then mechanically refining the cellulose-rich solids to generate the nanocellulose. |
| US10544264B2 |
Impact resistant flame retardant polyhexahydrotriazine polymers via generation of polyhexahydrotriazine monomers and hexahydro-1,3,5-triazine small molecules
An impact resistant polyhexahydrotriazine polymer, a process for forming an impact resistant polyhexahydrotriazine polymer, and an article of manufacture comprising an impact resistant material containing an impact resistant polyhexahydrotriazine polymer are disclosed. The impact resistant polyhexahydrotriazine polymer includes at least one hexahydrotriazine group and at least one chain comprising an allylic portion and a styrenic portion. Variations in the chain control properties of the impact resistant polymer. The process of forming the impact resistant polyhexahydrotriazine polymer includes reactions between formaldehyde and at least two classes of monomer that form hexahydrotriazine groups and impact resistant chains. Adjusting relative monomer concentrations controls properties of the impact resistant polyhexahydrotriazine polymer. The article of manufacture contains a material that has an impact resistant polymer. Impact resistance of the impact resistant polyhexahydrotriazine polymer is dependent upon variation in relative amounts of monomers used in its synthesis. |
| US10544261B2 |
Phosphinated poly(2,6-dimethyl phenylene oxide) oligomers and thermosets thereof
The present invention relates to a phosphinated poly(2,6-dimethy phenylene oxide)oligomer, specifically an unsaturated group-containing phosphinated poly(2,6-dimethy phenylene oxide)oligomer, and processes for producing the same. A thermoset produced from the unsaturated group-containing phosphinated poly(2,6-dimethy phenylene oxide)oligomers according to the present invention exhibits flame retardancy and has a low dielectric constant and dissipation factor and a high glass transition temperature. |
| US10544260B2 |
Fluoropolymers, methods of preparing fluoropolymers, and coating compositions containing fluoropolymers
A fluoropolymer having fluoropolyether linkages, at least two ester linkages, and hydrolyzable functional groups is represented by chemical structure (I): With respect to chemical structure (I), m is a number from 1 to 4 and n is a number from 10 to 60, each R1 is independently fluorine or CF3, R2 is an alkylene group, R3 is an alkylene group in which one or more hydrogens of the alkylene group are optionally substituted with fluorine, R4 is an alkyl group in which one or more hydrogens of the alkyl group are substituted with fluorine, R5 is an alkylene group in which at least one hydrogen of the alkylene group is substituted with a group comprising CF3, CF2H, or a hydrolyzable silyl group, and Z is a group represented by chemical structure (II), Methods of preparing the fluoropolymer and coating compositions containing the fluoropolymer are also included. |
| US10544259B2 |
Polycarbonate with low chlorine content and a method of making and analyzing the same
An aromatic polycarbonate, having an aromatic polycarbonate backbone, can comprise: less than or equal to 5 ppm of polymeric chlorine attached to the aromatic polycarbonate backbone; less than 0.5 ppm of dichloromethane, less than 5 ppm of monohydric phenols, and less than 0.5 ppm of aromatic compounds containing no chlorine based on the total weight of the aromatic polycarbonate, wherein the aromatic compounds are compounds other than the aromatic polycarbonate. |
| US10544258B2 |
Poly(butylene terephthalate) method and associated composition and article
A method for reducing outgassing of a polyester composed of repeat units derived from 1,4-butanediol is melt blending the polyester with 0.2 to 2 weight percent water, based on the weight of the polyester. In addition to water, the polyester can also be blended with 0.01 to 0.5 weight percent of a quencher. The method results in formation of a polyester composition which exhibits reduced outgassing, and is suitable for molding into articles, for example an automotive headlight reflector or bezel. |
| US10544256B2 |
Use of oligo-N,N-bis(3-aminopropyl)methylamine as curing agent for epoxy resins
The present invention relates to the use of oligo-N,N-bis(3-aminopropyl)methylamine as hardener for epoxy resins, and also to a corresponding curable composition, curing thereof, and the cured epoxy resin obtainable therefrom. |
| US10544254B2 |
Preparation and application of dicyclopentadiene-phenol and 2,6-dimethyl phenol copolymer epoxy resin
This invention provides a new dicyclopentadiene phenol and 2,6-dimethyl phenol copolymer epoxy resin with excellent heat resistance, low dielectric constant Dk, low dissipation factor Df having the formula 1. Preparation of dicyclopentadiene phenol and 2,6-dimethyl phenol copolymer epoxy resin in two steps: Step 1, reacting (a1) dicyclopentadiene phenol resin represented by formula 2 with (a2) 2,6-dimethyl phenol in the presence of acid catalyst by (a3) aldehyde compounds to synthesize dicyclopentadiene phenol-2,6-dimethyl phenol copolymer, and Step 2, reacting dicyclopentadiene phenol and 2,6-dimethyl phenol copolymer with excess epichlorhydrin under NaOH condition to prepare dicyclopentadiene phenol and 2,6-dimethyl phenol copolymer epoxy resin. When this dicyclopentadiene phenol and 2,6-dimethyl phenol copolymer epoxy resin according to the present invention is substituted into compositions for laminate, they have low dielectric constant, low dissipation factor, and no delamination after longer than 10 minutes 288° C. soldering test and 2 hours pressure cooking test. |
| US10544248B2 |
Crosslinkable resin composition, crosslinked product, and method for producing thereof, and multilayered structure
OBJECTAn object is to provide a resin composition capable of forming a crosslinked product that is excellent in hot water resistance and excellent in interlayer adhesiveness when formed into a multilayered structure.SOLUTIONThe resin composition contains an ethylene-vinyl alcohol copolymer (A) and a crosslinking agent (B) with the crosslinking agent (B) in an amount of 0.6 to 15 parts by mass relative to 100 parts by mass of the ethylene-vinyl alcohol copolymer (A), the crosslinking agent (B) being a powder obtained by impregnating a porous body (BS) with a crosslinkable compound (BL) having three or more polymerizable groups and a melting point of no greater than 40° C. |
| US10544247B2 |
Supported hybrid metallocene catalyst, and method for preparing polyolefin using the same
The present disclosure relates to a supported hybrid metallocene catalyst and a method for preparing a polyolefin using the same. When the supported hybrid metallocene catalyst according to the present disclosure is used, a polyolefin with a multimodal molecular weight distribution and excellent environmental stress crack resistance can be prepared. |
| US10544246B2 |
Methods for supplying solid catalysts to a solution polymerization reactor
Disclosed is a solution polymerization process, or, alternatively, a method of delivering powder catalysts to a solution polymerization reactor, comprising combining a homogeneous single-site catalyst precursor with α-olefin monomers to form a polyolefin, wherein the homogeneous single-site catalyst precursor is in the form of (i) a dry powder, (ii) suspended in a aliphatic hydrocarbon solvent, or (iii) suspended in an oil or wax, wherein the homogeneous single-site catalyst precursor is at a concentration greater than 0.8 mmole/liter when suspended in the aliphatic hydrocarbon solvent prior to entering the solution polymerization reactor. |
| US10544245B1 |
Process for preparing a polyethylene product
The present invention relates to a process for preparing a polyethylene product having a multimodal molecular weight distribution, said process comprising the steps of: (a) feeding ethylene monomer, a diluent, at least one metallocene catalyst, optionally hydrogen, and optionally one or more olefin co-monomers into a first slurry loop reactor; and polymerizing the ethylene monomer, and the optionally one or more olefin co-monomers, in the presence of said at least one metallocene catalyst, and optionally hydrogen, in said first slurry loop reactor thereby producing a first polyethylene fraction; (b) feeding the first polyethylene fraction to a second slurry loop reactor serially connected to the first slurry loop reactor, and in the second slurry loop reactor polymerizing ethylene, and optionally one or more olefin co-monomers, in the presence of the first polyethylene fraction, and optionally hydrogen, thereby producing a second polyethylene fraction; and (c) feeding the second polyethylene fraction to a gas phase reactor serially connected to the second slurry loop reactor, and in the gas phase reactor polymerizing ethylene, and optionally one or more olefin co-monomers, in the presence of the second polyethylene fraction, and optionally hydrogen, thereby producing the polyethylene product, wherein at least 25% by weight of the polyethylene product is prepared in the first slurry loop reactor. |
| US10544241B2 |
Farnesene-based macromonomers and methods of making and using the same
A macromonomer precursor is provided that includes a polymeric chain derived from farnesene and a single functional terminal end. The functional terminal end may include a hydroxyl group, an amino group, an epoxy group, an isocyanato group, or a carboxylic acid group. The terminal end of the macromonomer precursor may then be reacted with a (meth)acrylate to form a macromonomer having a (meth)acrylate functionalized terminal end that may be (co)polymerized with radically polymerizable monomers, such as alkyl(meth)acrylate monomers. Alternatively, a copolymer may be obtained by first deriving a poly(meth)acrylate from (meth)acrylate monomers having reactive groups that would allow the macromonomer precursors to be grafted onto the poly(meth)acrylate in a second step. The resulting copolymer may be incorporated as an additive in various formulations, such as a lubricant, a hydraulic fluid, a cosmetic composition, and an adhesive composition. |
| US10544240B2 |
Ethylene polymer, stretched molded article, microporous membrane and fiber
The present invention provides an ethylene polymer having a viscosity average molecular weight of 100×104 or more and 1,000×104 or less, in which a ratio between an isothermal crystallization time at 125° C. and an isothermal crystallization time at 123° C. obtained under specific isothermal crystallization time measurement conditions is 3.5 or more and 10.0 or less, and a degree of crystallization obtained using a differential scanning calorimeter (DSC) is 40% or more and 75% or less. |
| US10544236B2 |
Dual catalyst system for producing LLDPE copolymers with improved processability
Disclosed herein are ethylene-based polymers generally characterized by a density from 0.89 to 0.93 g/cm3, a ratio of Mw/Mn from 3 to 6.5, a Mz from 200,000 to 650,000 g/mol, a CY-a parameter at 190° C. from 0.2 to 0.4, and a reverse short chain branching distribution. The ATREF profile of these polymers can have a high temperature peak from 92 to 102° C., and a low temperature peak from 18 to 36° C. less than that of the high temperature peak. These polymers can have comparable physical properties to that of a metallocene-catalyzed LLDPE, but with improved processability, shear thinning, and melt strength, and can be used in blown film and other end-use applications. |
| US10544231B2 |
Antibodies for the prevention or the treatment of bleeding episodes
The invention relates to an isolated monoclonal antibody that specifically binds to the D4 domain of VWF, competes for binding to VWF D4 domain with ADAMTS13 and partially inhibits ADAMTS 13-mediated degradation of VWF. More particularly, the invention relates to an isolated monoclonal antibody comprising a heavy chain wherein the variable domain comprises at least one CDR having a sequence selected from the group consisting of SEQ ID NO: 3 for H-CDR1, SEQ ID NO: 4 for H-CDR2 and SEQ ID NO: 5 for H-CDR3 and a light chain wherein the variable domain comprises at least one CDR having a sequence selected from the group consisting of SEQ ID NO: 7 for L-CDR1, SEQ ID NO: 8 for L-CDR2 and SEQ ID NO: 9 for L-CDR3. Antibodies of the invention are presented to be useful in for the prevention or the treatment of bleeding episodes, such as bleeding episodes occurring in patients with aortic stenosis or patients with ventricular assist devices (VAD). |
| US10544230B2 |
Methods of using antibodies to detect folate receptor 1 (FOLR1)
The invention generally relates to antibodies that bind to human folate receptor and diagnostic assays for folate receptor 1-based therapies. Methods of using the antibodies to monitor therapy are further provided. |
| US10544227B2 |
Pharmaceutical composition for prevention and/or treatment of atopic dermatitis comprising IL-31 antagonist as active ingredient
In a non-limiting embodiment, there is provided a pharmaceutical composition for prevention and/or treatment of atopic dermatitis comprising an IL-31 antagonist as an active ingredient, wherein the IL-31 antagonist is repeatedly administered in equal amounts at the same dosing interval to a subject with or potentially with atopic dermatitis, at 0.1 to 1000 mg/body/1 day to 12 weeks, preferably at 0.1 to 1000 mg/body/2 weeks, 0.1 to 1000 mg/body/4 weeks, or 0.1 to 1000 mg/body/8 weeks. |
| US10544221B2 |
Single chain variable fragment CD3 binding proteins
Disclosed herein are single chain variable fragment CD3 binding proteins with improved binding affinities, and robust aggregation profiles. Also described are multispecific binding proteins comprising a single chain variable fragment CD3 binding protein according to the instant disclosure. Pharmaceutical compositions comprising the binding proteins disclosed herein and methods of using such formulations are provided. |
| US10544220B2 |
Bispecific antibodies against CD3 and CD20
Bispecific antibodies directed to CD3 and CD20 and uses of such bispecific antibodies, in particular use thereof in the treatment of diseases in which specific targeting and T cell-mediated killing of cells that express CD20 is desired. |
| US10544217B2 |
Anti-PD-1 antibodies
Antibodies that bind to programmed cell death protein 1 (PD-1), compositions comprising such antibodies, and methods of making and using such antibodies are disclosed. |
| US10544212B2 |
Anti-IL-33 antibodies, compositions, methods and uses thereof
The invention provides antibodies, and antigen-binding fragments thereof, that specifically bind to IL-33, as well as uses, and associated methods thereof. |
| US10544210B2 |
Anti-Rho GTPase conformational single domain antibodies and uses thereof
The present invention relates to active form specific anti-Rho GTPase conformational single domain antibodies and their uses in particular in the therapeutic and diagnostic fields. In particular, the present invention relates to a single domain antibody wherein the amino acid sequences of CDR1-IMGT, CDR2-IMGT and CDR3-IMGT have at least 90% of identity with the amino acid sequences of the CDR1-IMGT, CDR2-IMGT and CDR3-IMGT of the H12, B6, 4P75, 4SP1, 4SNP36, 4SNP61, 5SP10, 5SP11, 5SP58, 5SNP47, 5SNP48, 5SNP65, B20, B15, B5, B71, E3, A6, G12, NB61, 212B, 111B or 404F (hs2dAb) single domain antibody which are defined in Table B. |
| US10544203B2 |
Human FGFR2B extracellular domain and nucleic acid for coding same
Provided are wild-type, S252W mutant-type, and P253R mutant-type FGFR2b extracellular segments and truncated proteins thereof, coding genes of the foregoing proteins, a recombinant vector comprising the genes, a host cell, a method for preparing the proteins, and a fusion protein of the proteins and an Fc segment. Also provided are applications of the proteins and a composition comprising the proteins in treating eczema, acne, psoriasis, skin allergy, seborrheic dermatitis, or seborrheic alopecia. |
| US10544202B2 |
Mutant proteins and methods for their production
The present invention relates to mutant transmembrane proteins which have increased conformational stability when compared to their parent protein, methods of selection and production. In particular the invention relates to mutant transmembrane proteins which are mutated in or in the proximity of the transmembrane alpha helices or in a kinked region or in an alpha-helix adjacent to a kink. The mutant transmembrane proteins have use in crystallisation studies and also in screening to identify compounds for use in drug discovery and therapy. |
| US10544199B2 |
Interferon alpha 2B variants
The present invention provides a fusion polypeptide comprising a first domain and a second domain, wherein the first domain comprises a polypeptide ligand which binds to a cell surface-associated antigen and the second domain comprises aglycosylated interferon α 2b (IFNα2b) having a sequence of SEQ ID NO: 1 or SEQ ID NO: 2. The aglycosylated IFNα2b further comprises one or more amino acid substitutions or deletions which attenuate the activity of the aglycosylated IFNα2b. |
| US10544195B2 |
Polypeptides having cellulolytic enhancing activity and nucleic acids encoding same
The present invention relates to isolated polypeptides having cellulolytic enhancing activity and isolated polynucleotides encoding the polypeptides. The invention also relates to nucleic acid constructs, vectors, and host cells comprising the polynucleotides as well as methods for producing and using the polypeptides. |
| US10544194B2 |
Mutant fragments of OspA and methods and uses relating thereto
The present invention relates to a polypeptide comprising a mutant fragment of an outer surface protein A (OspA), a nucleic acid coding the same, a pharmaceutical composition (particularly for use as a medicament of in a method of treating or preventing a Borrelia infection) comprising the polypeptide and/or the nucleic acid, a method of treating or preventing a Borrelia infection and a method of immunizing a subject. |
| US10544193B2 |
Compositions and methods for treating diseases by inhibiting exosome release
A multipartite peptide that inhibits release of exosomes in a cell, comprising an N-terminal end and a C-terminal end and comprising at least one secretion modifying region (SMR) peptide from HIV-1 Nef and at least one Clusterin (Clu)-binding peptide (Clu-BP). Pharmaceutical compositions comprising these peptides alone or in synergistic combinations with other active agents in methods for treating cancers and/or infectious diseases are further provided herein. |
| US10544192B2 |
Chimpanzee clade E adenovirus nucleic acid-and amino acid-sequences, vectors containing same, and uses thereof
The present invention relates to novel adenovirus strains with an improved seroprevalence. In one aspect, the present invention relates to isolated polypeptides of adenoviral capsid proteins such as hexon, penton and fiber protein and fragments thereof and polynucleotides encoding the same. Also provided is a vector comprising the isolated polynucleotide according to the invention and adenoviruses comprising the isolated polynucleotides or polypeptides according to the invention and a pharmaceutical composition comprising said vector, adenovirus, polypeptide and/or polynucleotide. The invention also relates to the use of the isolated polypeptides, the isolated polypeptides, the vector, the adenoviruses and/or the pharmaceutical composition for the therapy or prophylaxis of a disease. |
| US10544190B2 |
Peptide that supresses binding of beta-amyloid and rage
The present invention provides a peptide consisting of the amino acid sequence of SEQ ID NO:1 or the amino acid sequence of SEQ ID NO:2, or a pharmaceutically acceptable salt thereof and a use thereof. The present invention can inhibit the entry of beta-amyloid into the brain. In addition, the present invention can be applied more easily with respect to the suppression of the intracerebral action of beta-amyloid and thus is advantageous in having excellent applicability. |
| US10544188B2 |
Inhibitor of apoptosis protein (IAP) antagonists
Provided herein are compounds that modulate the activity of inhibitor of apoptosis proteins (IAPs), compositions comprising the compounds, and methods of using the compounds and compositions comprising the compounds. |
| US10544184B2 |
Uracyl spirooxetane nucleosides
The present invention relates to compound of the formula I: including any possible stereoisomers thereof, wherein R9 has the meaning as defined herein, or a pharmaceutically acceptable salt or solvate thereof. The present invention also related to processes for preparing said compounds, pharmaceutical compositions containing them and their use, alone or in combination with other HCV inhibitors, in HCV therapy. |
| US10544181B2 |
Sugar derivative gelators
A novel gelator including a sugar derivative; a gelator including a compound of Formula (1) or Formula (2): wherein R1 is a linear or branched alkyl group having a carbon atom number of 9 to 20, a cyclic alkyl group having a carbon atom number of 13 to 20, or a linear or branched alkenyl group having a carbon atom number of 9 to 20, R2 is a hydrogen atom, a linear or branched alkyl group having a carbon atom number of 1 to 10, or an aryl group optionally having a substituent, and R3 and R4 are hydroxy groups. |
| US10544180B2 |
Process for preparing compositions comprising alkyl(alkyl-glucoside)uronates, said compositions and use thereof as a surfactant
Some embodiments relate to a novel process for preparing compositions including alkyl(alkyl-glucoside)uronates, from biobased or biocompatible/biodegradable raw materials, and also salts and acids thereof. |
| US10544175B2 |
Crystalline fosaprepitant dicyclohexylamine salt and its preparation
Dicyclohexylamine salt of fosaprepitant (fosaprepitant DCHA), a process for preparing fosaprepitant DCHA, and a use of fosaprepitant DCHA in the preparation of pharmaceutically acceptable fosaprepitant dimeglumine with high purity is provided. Fosaprepitant dimeglumine is prepared by treating fosaprepitant DCHA with an acid to form fosaprepitant, followed by adding N-methyl-D-glucamine to fosaprepitant. |
| US10544173B2 |
Phosphate ester composition and use
A phosphate ester composition comprising more than 50 mass % of a phosphate ester represented by Formula 1, wherein X, Y, and Z are independently selected from the group consisting of alkyl, heteroalkyl, heteroaryl or aryl, with at least one of X, Y and Z being aryl, represented by Formula 2, and wherein two or more of R3, R4 and R5 have from 1 to 10 carbon atoms, and the total number of carbon atoms in R3, R4 and R5 is from 3 to 30. The use of the phosphate ester composition as a flame retardant, a lubricant, an anti-wear additive, a hydraulic fluid, a self-extinguishing functional fluid, or an additive thereof. |
| US10544171B2 |
Process for producing cyclic hydrogenated silane compound
A process for producing a cyclic hydrogenated silane compound comprising: a decomplexation step of contacting a salt of a cyclic halosilane compound with a Lewis acid compound to react, thereby obtaining a cyclic halosilane compound; and a reduction step of contacting the cyclic halosilane compound with a metal hydride to reduce the cyclic halosilane compound, thereby obtaining a cyclic hydrogenated silane compound. |
| US10544170B2 |
Organosilicon compound and method for producing same
Provided are an organosilicon compound capable of improving the storage stability of a composition (curability after long-term storage); and a method for producing the same. The organosilicon compound has, in one molecule, at least one carboxylic acid ester group represented by the following general formula (1) and at least one hydrolyzable silyl group represented by the following general formula (2): —OC(═O)CH2R1 (1) wherein R1 represents a hydrogen atom or a methyl group; —SiR23-nYn (2) wherein R2 represents a substituted or unsubstituted monovalent hydrocarbon group having 1 to 12 carbon atoms, Y represents a hydrolyzable group, and n represents an integer satisfying 1≤n≤3. |
| US10544168B2 |
Ligand-exchangeable nanoparticles and methods of making the same
An aspect of the present disclosure is a nanocrystal that includes a nanocrystal core and a ligand coordinated to a surface of the nanocrystal core, where the ligand includes a functionalized aromatic molecule. In some embodiments of the present disclosure, the functionalized aromatic molecule may include at least one of cinnamic acid (CAH) and/or a functionalized CAH molecule. |
| US10544167B2 |
Compounds as stimuli-responsive probes, methods and applications thereof
The present disclosure relates to the field of synthetic pharmaceutical chemistry and biology. The disclosure provides a compound of Formula I and a process of preparation thereof. The disclosure further relates to methods and use of Formula I compounds as stimuli-responsive probes. Said Formula I compounds are employed for detecting and quantifying reactive oxygen species (ROS), and have related applications including but not limited fluorescence spectroscopy, diagnostics, treatment, imaging and biomedical applications. |
| US10544165B1 |
Method of treating cancer and other proliferative diseases with a gold(I) complex
The invention is directed to a method of treatment of proliferative diseases or disorders such as cancer with gold(I) N-heterocyclic carbene (NHC) thiourea or substituted thiourea complexes, to the complexes per se and to therapeutic compositions containing these gold(I) based complexes. |
| US10544164B2 |
Nitrogen-containing macrocyclic conjugates as radiopharmaceuticals
The present invention relates to compounds that are useful as metal ligands and which either contain a molecular recognition moiety or can be bound to a molecular recognition moiety and methods of making these compounds. Once the compounds that contain a molecular recognition moiety are coordinated with a suitable metallic radionuclide, the coordinated compounds are useful as radiopharmaceuticals in the areas of radiotherapy and diagnostic imaging. The invention therefore also relates to methods of diagnosis and therapy utilising the radiolabelled compounds of the invention. |
| US10544163B2 |
Condensed heterocyclic compounds and pesticides
To provide novel pesticides, especially insecticides or acaricides.A condensed heterocyclic compound represented by the formula (1) or its salt, or N-oxide thereof: wherein Q is a structure represented by Q1, Q2 or the like, D substituted with —S(O)nR1 is a structure represented by D1 or D2, A1 is N(A1 a) or the like, A1 a is C1-C6 alkyl or the like, A4 is a nitrogen atom or C(R4), A5 is a nitrogen atom or C(R5), R1 is C1-C6 alkyl or the like, each of R2, R5 and R6 is independently a hydrogen atom or C1-C6 alkyl, each of R3, R4, Y1, Y2, Y3 and Y4 is independently a halogen atom, halo (C1-C6) alkyl or the like, and n is an integer of 0, 1 or 2. |
| US10544162B2 |
Polymorphic form of TG02
The present disclosure provides crystalline polymorphic forms of TG02 free base and TG02 acid addition salts, pharmaceutical compositions comprising crystalline polymorphic forms of TG02 free base and TG02 acid addition salts, and methods of treating cancer and other diseases in a patient with crystalline polymorphic forms of TG02 free base and TG02 acid addition salts. |
| US10544161B2 |
Anti-fibrotic pyridinones
Disclosed are pyridinone compounds, method for preparing these compounds, and methods for treating fibrotic disorders. |
| US10544154B2 |
Opioid receptor antagonist prodrugs
Provided herein are prodrugs of opioid receptor antagonists such as nalmefene and naltrexone, pharmaceutical compositions comprising said compounds, and methods for using said compounds for the treatment of behavioral disorders. |
| US10544150B2 |
NK-3 receptor selective antagonist compounds, pharmaceutical composition and methods for use in NK-3 receptors mediated disorders
The present invention is directed to novel compounds of formula I and their use as therapeutic compounds. |
| US10544148B2 |
Pesticidally active tetracyclic heterocyclic derivatives with sulphur containing substituents
Compounds of formula (I), wherein the substituents are as defined in claim 1, and the agrochemically acceptable salts salts, stereoisomers, enantiomers, tautomers and N-oxides of those compounds, can be used as insecticides and can be prepared in a manner known per se. |
| US10544147B2 |
Purine inhibitors of human phosphatidylinositol 3-kinase delta
The instant invention provides compounds of formula (I) which are PI3K-delta inhibitors, and as such are useful for the treatment of PI3K-delta-mediated diseases such as inflammation, asthma, COPD and cancer. |
| US10544141B2 |
Derivatives and methods of treating hepatitis B infections
Provided herein are compounds useful for the treatment of HBV infection in a subject in need thereof, pharmaceutical compositions thereof, and methods of inhibiting, suppressing, or preventing HBV infection in the subject. |
| US10544135B2 |
Process for the preparation of compounds useful as inhibitors of SGLT2
The present invention is directed to a novel process for the preparation of compounds having inhibitory activity against sodium-dependent glucose transporter (SGLT) being present in the intestine or kidney. |
| US10544133B2 |
Heteroaryl substituted pyridyl compounds useful as kinase modulators
Compounds having the following formula: or a stereoisomer or a pharmaceutically-acceptable salt thereof, wherein R2 is a monocyclic heteroaryl group, and R1, R3, R4, R5 and R6 are as defined herein, are useful as kinase modulators, including IRAK-4 inhibition. |
| US10544131B2 |
MCL-1 antagonists
Provided herein are Mcl-1 antagonist compositions and methods of treating cancer using the compositions described herein. |
| US10544125B2 |
Process for preparing an anti-cancer agent, 1-((4-(4-fluoro-2-methyl-1H-indol-5-yloxy)-6-methoxyquinolin-7-yloxy)methyl)cyclopropanamine, its crystalline form and its salts
The present invention relates a new process to synthesize 1-((4-(4-Fluoro-2-methyl-1H-indol-5-yloxy)-6-methoxyquinolin-7-yloxy)methyl)cyclopropanamine (AL3818). A stable crystalline form of Al3818 has been prepared. Salts and their crystalline forms of AL3818 have been also prepared. Anti-cancer and optometric activities of AL3818 and its salts have been further tested. New process has been outlined in Scheme I. |
| US10544122B2 |
TLR7/8 antagonists and uses thereof
Compounds of Formula 1 and pharmaceutically acceptable compositions thereof are useful as TLR7/8 antagonists. |
| US10544119B2 |
Preparation method for chiral intermediate for use in statins
The present invention relates to a preparation method for a chiral intermediate for use in statins, acquired with chloroacetic acid and benzyl alcohol as starting materials via a series of reactions, namely etherification, condensation, substitution, and asymmetric reduction. The preparation method provided in the present invention has a novel route of synthesis, allows an intermediate compound to be introduced conveniently into the chiral center of a glycol via enzyme reduction, and not only is low in costs, but also is reliable in quality. The route of synthesis provided in the present invention uses raw materials of low costs, has an easy to operate process, and provides a final product of great purity and high yield. |
| US10544118B2 |
Oxidation process to produce 5 methyl 5-methylfuran-2-carboxylate (MMFC)
Disclosed herein is a very efficient method to make 5-(alkoxycarbonyl)furan-2-carboxylic acids (ACFC) from feedstocks comprised of furoates. When a feedstock comprised of methyl 5-methylfuran-2-carboxylate (MMFC) is used a product comprised of (5-(methoxycarbonyl)furan-2-carboxylic acid (MCFC) is obtained in high yield. |
| US10544116B2 |
Process for purifying propylene oxide
Disclosed herein is a process for purifying propylene oxide, including the steps of: (i) providing a stream S0 containing propylene oxide, acetonitrile, water, and an organic compound containing a carbonyl group —C(═O)—; and (ii) separating propylene oxide from the stream S0 by subjecting the stream S0 to distillation conditions in a distillation column to obtain a gaseous top stream S1c which is enriched in propylene oxide compared to the stream S0, a liquid bottoms stream S1a which is enriched in acetonitrile and water compared to the stream S0, and a side stream S1b containing propylene oxide which is enriched in the carbonyl compound compared to the stream S0. |
| US10544115B2 |
Process for the preparation of propylene oxide
A continuous process for the preparation of propylene oxide, comprising a start-up stage and normal run stage, wherein the normal run stage comprises (i) continuously providing a liquid feed stream comprising propene, hydrogen peroxide, acetonitrile, a formate salt, water and optionally propane, wherein in the liquid feed stream, the molar amount of the formate salt relative to the molar amount of hydrogen peroxide at a given point of time during the normal run stage is aN(Fo/H2O2); (ii) continuously passing the liquid feed stream provided in (i) into an epoxidation zone comprising a catalyst comprising a titanium zeolite having framework type MWW, and subjecting the liquid feed stream to epoxidation reaction conditions in the epoxidation zone, obtaining a reaction mixture comprising propylene oxide, acetonitrile, water, the formate salt, optionally propene, and optionally propane; (iii) continuously removing an effluent stream from the epoxidation zone, the effluent stream comprising propylene oxide, acetonitrile, water, at least a portion of the formate salt, optionally propene, and optionally propane; wherein the normal run stage is characterized in an average rate of change of aN(Fo/H2O2) of less than 0 h−1. |
| US10544114B2 |
Process for preparing oxathiazin-like compounds
Oxathiazin-like compounds, processes for making new oxathiazin-like compounds, compounds useful for making oxathiazin-like compounds, and their uses are disclosed. Processes for efficient and safe manufacture of compounds useful for making oxathiazin-like compounds useful for treating patients suffering from cancers, bacterial infections, fungal infections and/or viral infections by administering oxathiazin-like compounds are also disclosed. |
| US10544112B2 |
Identification of ebsulfur analogues with broad-spectrum antifungal activity
The invention relates to novel ebsulfur analogues and novel pharmaceutical compositions comprising ebsulfur analogues. The invention also relates to novel methods of treating infections caused by fungal species comprising administration of ebselen, ebsulfur, and ebsulfur analogues. |
| US10544110B2 |
Small molecule inhibitors of the nuclear translocation of androgen receptor for the treatment of castration-resistant prostate cancer
A compound, or a pharmaceutically acceptable salt or ester thereof, according to formula I: R20—(Z)b—(Y)c—(R21)a—(X)d—R22—R23 wherein R20 is aryl, substituted aryl, heteroaryl, substituted heteroaryl, heterocycloalkyl, substituted heterocycloalkyl, alkoxy, aryloxy, a thio-containing group, or a seleno-containing group; Z is alkanediyl, substituted alkanediyl, cycloalkanediyl, or substituted cycloalkanediyl; Y is S, O, S(═O), —S(═O)(═O)—, or NR10, wherein R10 is H or alkyl; R21 is alkanediyl, substituted alkanediyl, cycloalkanediyl, substituted cycloalkanediyl alkadienyl, substituted alkadienyl, alkatrienyl, substituted alkatrienyl; X is —C(═O)—, —S(═O)(═O)—, or —N(H)C(═O)—; R22 includes at least one divalent amino radical; R23 is aryl, substituted aryl, heteroaryl, substituted heteroaryl, heterocycloalkyl, substituted heterocycloalkyl, alkoxy, aryloxy, a thio-containing group, or a seleno-containing group; a, b, c, and d independently are 0 or 1. |
| US10544107B2 |
Process for the preparation of 2-{4-[(5,6-diphenyl pyrazin-2-yl)(isopropyl)amino]butoxy}-N-(methylsulfonyl)acetamide and novel polymorphs thereof
The present invention relates to a processes for the preparation of 2-{4-[(5,6-diphenyl pyrazin-2-yl)(isopropyl)amino]butoxy}-N-(methylsulfonyl)acetamide compound of formula-1 and novel polymorphs thereof. |
| US10544103B2 |
5-HT2 antagonists
Provided are 1-amidino-3-aryl-2-pyrazoline derivatives which exhibit antagonizing activity towards serotonin 5-HT 2B receptors and pharmaceutical compositions containing these derivatives. Also provided is the use of the compounds as a medicament and for the treatment of fibrosis, cardiovascular diseases, pain, IBD, and other inflammatory diseases. |
| US10544099B2 |
Inhibitors of indoleamine 2,3-dioxygenase and methods of their use
There are disclosed compounds that modulate or inhibit the enzymatic activity of indoleamine 2,3-dioxygenase (IDO), pharmaceutical compositions containing said compounds and methods of treating proliferative disorders, such as cancer, viral infections and/or inflammatory disorders utilizing the compounds of the invention. |
| US10544097B2 |
Solid state forms of N-[2-[(1S)-1-(3-ethoxy-4-methoxyphenyl)-2-(methylsulfonyl)ethyl]-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]acetamide and process for preparation thereof
The present invention, relates to solid state forms of N-[2-[(1S)-1-(3-ethoxy-4-methoxyphenyl)-2-(methylsulfonyl)ethyl]-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]acetamide represented by the following structural formula-1 and process for their preparation. The present invention also relates to an improved process for the preparation of N-[2-[(1S)-1-(3-ethoxy-4-methoxyphenyl)-2-(methylsulfonyl)ethyl]-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]acetamide compound of formula-1 and intermediates thereof. |
| US10544096B2 |
Continuous methods of manufacture of 2-aryl-3,3-BIS(4-hydroxyaryl)phthalimidines, and polymers derived therefrom
A continuous method for the manufacture of a 2-aryl-3,3-bis(hydroxyaryl)phthalimidine comprising continuously heating an anhydride with a phenol in the presence of a catalyst and a first co-catalyst, to form a first reaction mixture comprising a phenolphthalein compound; precipitating the phenolphthalein compound; combining a primary arylamine with an acid catalyst and a second co-catalyst to form a second reaction mixture; adding the phenolphthalein compound to the second reaction mixture; continuously heating the second reaction mixture to provide a third reaction mixture comprising a crude phthalimidine; and treating the crude phthalimidine to remove aminophenol and purify the phthalimidine is provided. |
| US10544095B2 |
3-indol substituted derivatives, pharmaceutical compositions and methods for use
A compound of Formula I is provided: or pharmaceutically acceptable enantiomers, salts or solvates thereof. The invention further relates to the use of the compounds of Formula I as TDO2 inhibitors. The invention also relates to the use of the compounds of Formula I for the treatment and/or prevention of cancer, neurodegenerative disorders such as Parkinson's disease, Alzheimer's disease and Huntington's disease, chronic viral infections such as HCV and HIV, depression, and obesity. The invention also relates to a process for manufacturing compounds of Formula I. |
| US10544083B2 |
GPBP inhibition using Q2 peptidomimetics
Disclosed are compounds of formula: that inhibiting GPBP activity, making them useful as therapeutics in antibody-mediated disorders, drug-resistant cancer, inflammation, protein misfolding and ER stress-mediated disorders, and aberrant apoptosis. |
| US10544077B2 |
Process for making formic acid utilizing higher-boiling formate esters
Disclosed is a process for recovering formic acid from a formate ester that allows for recovery of a formic acid product comprising greater than 75 wt. % formic acid. Disclosed is also a process for producing formic acid by carbonylating a carrier alcohol, hydrolyzing the formate ester of the carrier alcohol, and recovering a formic acid product comprising greater than 70 wt. % formic acid. Discloses are carrier alcohols that enable more favorable hydrolysis equilibriums and/or distillation sequences. |
| US10544076B1 |
Method of making a dialdeyhde
We have discovered that a di-epoxide can be converted to a dialdehyde using an amorphous silica-alumina catalyst. The method comprises contacting a di-epoxide mixed in an organic solvent with a silica-alumina catalyst to form a solvent and dialdehyde reaction product mixture and separating said dialdehyde from said reaction mixture. The dialdehydes have utility as chemical intermediates, and particular utility in processes to make enol ether compounds which can be used in applications as plasticizers, diluents, wetting agents, coalescing aids and as intermediates in chemical processes. |
| US10544072B2 |
Continuous processes for the highly selective conversion of aldohexose-yielding carbohydrate to ethylene glycol
Continuous processes for making ethylene glycol form aldohexose-yielding carbohydrates are disclosed which enhance the selectivity to ethylene glycol. |
| US10544061B2 |
Vanadium dioxide
The present application provides vanadium dioxide doped with Ti, or vanadium dioxide further doped with other atoms selected from the group of W, Ta, Mo, and Nb. The vanadium dioxide of the present application is excellent in moisture resistance and in which deterioration of endothermic characteristics due to moisture is suppressed. |
| US10544059B2 |
Ion exchangeable glass, glass ceramics and methods for making the same
Glass-ceramics and precursor glasses that are crystallizable to glass-ceramics are disclosed. The glass-ceramics of one or more embodiments include rutile, anatase, armalcolite or a combination thereof as the predominant crystalline phase. Such glasses and glass-ceramics may include compositions of, in mole %: SiO2 in the range from about 45 to about 75; Al2O3 in the range from about 4 to about 25; P2O5 in the range from about 0 to about 10; MgO in the range from about 0 to about 8; R2O in the range from about 0 to about 33; ZnO in the range from about 0 to about 8; ZrO2 in the range from about 0 to about 4; B2O3 in the range from about 0 to about 12, and one or more nucleating agents in the range from about 0.5 to about 12. In some glass-ceramic articles, the total crystalline phase includes up to 20% by weight of the glass-ceramic article. |
| US10544057B2 |
Method of manufacturing preforms for optical fibres having low attenuation loss
A method of manufacturing a glass core preform for an optical fibre comprising: providing a porous soot core preform having an outer surface) and a central hole extending axially therethrough; dehydrating the porous soot core preform at a first temperature by exposing the outer surface of the preform to an atmosphere containing chlorine, and simultaneously consolidating the soot core preform and closing the central hole at a second temperature higher than the first temperature to form a glass core preform, wherein consolidating and closing comprises sequentially alternating flowing chlorine containing gas into the central hole and reducing the internal pressure of the central hole. |
| US10544055B2 |
Chelating base product for use in water-based system treatments
A base product fluid is produced by adding anhydrous liquid ammonia and a first portion of sulfuric acid to water in a process line to form a mixed fluid. The mixed fluid may be cooled and a second portion of sulfuric acid may be added to the mixed fluid to form the base product fluid. The base product fluid may include a molecular compound that is a chelating compound. The molecular compound may have the formula: ((NH4)2SO4)a.(H2SO4)b.(H2O)c.(NH4HSO4)x. In the formula, a may be between 1 and 5, b may be between 1 and 5, c may be between 0 and 5, and x may be between 1 and 20. |
| US10544054B2 |
Method for detecting and controlling the amount of cationic species in a water stream
A method for detecting and controlling the amount of cationic species in a water stream in accordance with embodiments of the present disclosure is carried out by adding a solution containing a pre-determined quantity of a fluorescent tracer to the sample of water stream to obtain a solution comprising a complex. The fluorescence emission spectra of the solution is measured for detecting the presence or absence of the cationic species based on the attenuation and shift of the emission peak in the range of 640 nm to 655 nm. |
| US10544048B2 |
Waterborne aerogel and method for producing same
Disclosed is a water-dispersed aerogel, having an eco-friendly composition that contains an organic solvent in a decreased amount while increasing ease of use of aerogel microparticles in a liquid phase and a method of manufacturing the water-dispersed aerogel is also provided. |
| US10544046B2 |
Methods and systems for the synthesis of nanoparticles including strained nanoparticles
A method for synthesizing nanoparticles includes aerosolizing a precursor solution in the presence of a flowing carrier gas to yield a reactant stream, the precursor solution comprising a volatile solvent and a nanoparticle precursor. The method further includes heating the reactant stream to a temperature above a boiling point of the volatile solvent to form a product stream comprising a plurality of nanoparticles, cooling the product stream, and passing the product stream through a collection liquid to collect the nanoparticles from the product stream. |
| US10544042B2 |
Nanoparticle structure and process for manufacture
A method for forming nanoparticles includes forming a stack of alternating layers including a first material disposed between a second material. The stack of alternating layers is patterned to form pillars. A dielectric layer is conformally deposited over the pillars. The pillars are annealed in an oxygen environment to modify a shape of the first material of the alternating layers. The dielectric layer and the second material are etched selectively to the first material to form nanoparticles from the first material. |
| US10544041B2 |
Method for manufacturing graphene-coated object, negative electrode of secondary battery including graphene-coated object, and secondary battery including the negative electrode
To form graphene to a practically even thickness on an object having an uneven surface or a complex surface, in particular, an object having a surface with a three-dimensional structure due to complex unevenness, or an object having a curved surface. The object and an electrode are immersed in a graphene oxide solution, and voltage is applied between the object and the electrode. At this time, the object serves as an anode. Graphene oxide is attracted to the anode because of being negatively charged, and deposited on the surface of the object to have a practically even thickness. A portion where graphene oxide is deposited is unlikely coated with another graphene oxide. Thus, deposited graphene oxide is reduced to graphene, whereby graphene can be formed to have a practically even thickness on an object having surface with complex unevenness. |
| US10544039B2 |
Methods for depositing a measured amount of a species in a sealed cavity
Methods for depositing a measured amount of a species in a sealed cavity. In one example, a method for depositing molecules in a sealed cavity includes depositing a selected number of microcapsules in a cavity. Each of the microcapsules contains a predetermined amount of a first fluid. The cavity is sealed after the microcapsules are deposited. After the cavity is sealed the microcapsules are ruptured to release molecules of the first fluid into the cavity. |
| US10544038B2 |
MEMS microphone and method of manufacturing the same
A MEMS microphone includes a substrate having a cavity, a back plate provided over the substrate and having a plurality of acoustic holes, a diaphragm disposed between the substrate and the back plate, and spaced apart from the substrate and the back plate, a strut located at outer side of the diaphragm, having a lower surface in contact with an upper surface of the substrate and being integrally formed with the upper insulation layer to support the upper insulation layer to space the upper insulation layer from the diaphragm, and a bending prevention member provided on an upper surface of the back plate for preventing the back plate from being bent. |
| US10544035B2 |
Sensor component having two sensor functions
A sensor component having a MEMS sensor and an ASIC for one sensor function each. A base element, a wall element in the form of a frame and a cover together enclose a cavity of a housing. The MEMS sensor is mounted inside the cavity on the base element of the housing. The ASIC has an active sensor surface and is mounted on or under the cover or is embedded in the cover. Electrical external contacts for the MEMS sensor and ASIC are provided on an external surface of the housing. The cavity has at least one opening or bushing. |
| US10544032B2 |
MEMS device
A MEMS device includes a plurality of ribbon elements, a securing portion, and a plurality of connecting portions. The securing portion supports the plurality of ribbon elements. The plurality of connecting portions are disposed on ends of each of the plurality of ribbon elements and connect each of the plurality of ribbon elements to the securing portion. An angle formed by a longitudinal extending line of each of the plurality of ribbon elements and each of the plurality of connecting portions is greater than 0° in a planar direction of each of the plurality of ribbon elements. |
| US10544031B2 |
Systems and methods for detection of vehicle misfueling
Methods and systems are provided for identifying misfueling of a vehicle fuel tank with a fuel that is not of a correct type for the vehicle being refueled. In one example, and method may include routing fuel vapors from a vehicle fuel tank to a fuel vapor storage canister during a refueling operation, and responsive to an indication of misfueling, where the indication of misfueling includes a monitored pressure in the fuel tank below a misfueling pressure threshold, and where the misfueling pressure threshold is adjusted as a function of expected pressure in the tank during refueling, actively terminating the refueling event. In this way, addition of an incorrect fuel type to a vehicle fuel tank may be indicated prior to completion of refueling, which may thus alert a vehicle operator of the misfueling, and which may prevent further complications arising from operating the vehicle with an incorrect fuel type. |
| US10544026B2 |
Method and a system for introducing nitrogen into a beverage
The present invention relates to a method of introducing nitrogen into a beverage container. The beverage container (10) includes a cylindrical neck part (16) having a circumferential rim (18) defining an opening (20). The cylindrical neck part includes an outer circumferential flange (22) encircling the cylindrical neck part. A connecting element (36) having a circular closure plate (64) and a cylindrical housing (54) having a set of inwardly oriented locking parts (56) is positioned such that the cylindrical housing is at least partially covering the cylindrical neck part and a fluid path (58) is defined between the connecting element and the cylindrical neck part. A collar (42, 44) having a gas inlet (48) is placed about the cylindrical neck part and gas is injected into the beverage container via the gas inlet. Finally, the connecting element is moved towards the cylindrical neck part for arresting the connecting element to the cylindrical neck part and sealing the circular closure plate against the circumferential rim. |
| US10544021B2 |
Industrial vehicle and lighting device
An industrial vehicle includes a vehicle body, a head guard provided in the upper portion of the vehicle body, and a lighting device provided on the head guard and illuminating a space in front of the vehicle body. The lighting device is provided with a light illuminating the space in front of the vehicle body and brackets removably attached to a pipe of the head guard. The light is attached to the bracket so as to be positioned below the pipe and positioned beside or behind a front pillar of the head guard. |
| US10544020B2 |
Handling vehicle
The invention relates to a load-handling vehicle provided with a driver's cab (1) and including a device for transporting a tool (2), which device comprises a telescopic boom (3) mounted to pivot in a plane parallel to the longitudinal plane of the vehicle (B-B) by means of a lifting jack (4) under the control of a power plant (5) arranged in a side casing (6), which plane is vertical when the vehicle is resting on horizontal ground (7) via wheels (8, 9, 10, 11), of which at least two front wheels or two rear wheels are driven by said power plant, the power plant comprising an engine (5A), a hydrostatic pump (5B), and a hydraulic pump (5C).According to the invention, said pumps (5B, 5C) and at least 40% of the footprint area of said engine (5A) as projected onto a plane that is horizontal when the vehicle is resting on horizontal ground are located under said boom (3). |
| US10544019B2 |
Scissor lift with hydraulic pulling cylinder
A lift device configured to lift an object includes a stationary base, a lift assembly, a support assembly, and a lift mechanism. The lift assembly is movably coupled to the base, and the support assembly is movably coupled to the lift assembly. The support assembly is configured to support the object. The lift mechanism has an adjustable length. The lift mechanism is coupled to the base and to the lift assembly such that decreasing the length of the lift mechanism moves the support assembly upwardly and increasing the length of the lift mechanism moves the support assembly downwardly. |
| US10544018B2 |
Lift assembly with load cells
A lift assembly comprises a base, a drive mechanism, a flexible drive element extending from the drive mechanism along a fleet axis, and a sheave directing the drive element from the fleet axis to an output axis. The sheave is coupled to the base at a first sheave mount aligned with the fleet axis. The assembly can further include a second sheave mount aligned with the fleet axis and configured to be coupled to the sheave to allow the sheave to be de-coupled from the first sheave mount and coupled to the second sheave mount, resulting in substantially no change in a fleet angle of the fleet axis. Preferably, the sheave is positioned on a first side of the fleet axis when coupled to the first sheave mount, and the sheave is positioned on a second side of the fleet axis (e.g., opposite the first side) when coupled to the second sheave mount. |
| US10544016B2 |
Crane, vessel comprising such a crane, and a method for up-ending a longitudinal structure
A crane includes a base structure; a slew bearing; a crane housing; a boom moveably mounted to the crane housing to be pivotable about a horizontal first pivot axis; three main hoisting systems; and a luffing system. The boom includes an A-frame with two boom legs that are connected at one end to the crane housing and at the opposite end to each other. Each main hoisting system includes a hoisting cable; a sheave block; a hoisting block; and a hoisting winch. The sheave block of each main hoisting system is pivotable about a horizontal second pivot axis that is perpendicular to the sheave rotation axis. The sheave blocks of the three main hoisting systems are arranged side-by-side. The luffing system includes two luffing winches; and two luffing cables extending between the respective two luffing winches. The luffing cables are connected to respective outriggers of the hammerhead structure. |
| US10544012B2 |
Visual outrigger monitoring system
A system and method for visually monitoring an outrigger includes a camera assembly configured to monitor an outrigger and a control system operably and communicably connected to the camera assembly. The control system executes instructions to determine a presence, length, and/or position of the outrigger based by an image captured by the camera assembly. The outrigger may include a target to be detected by the camera assembly for monitoring of the outrigger. The target may be the outrigger itself, detected by the control system using edge detection, or a marker disposed on the outrigger. The system may be implemented with a crane having a carrier unit and a superstructure. The system may include a plurality of camera assemblies and a plurality of outriggers. |
| US10544010B2 |
Method and system for elevator door locking and detection of elevator door locking state
The disclosure provides for a locking system for an elevator car door that includes a locking apparatus mounted to the elevator car door. The locking apparatus includes an elevator door latch arm, a sensing vane, and a fixed vane. The elevator door latch arm has one end configured to be inserted into a catch to lock the elevator car door. The sensing and fixed vanes are generally parallel to one another. When the elevator car door is aligned with a hoistway door, an outer surface of the sensing vane is configured to engage with a roller on the hoistway door, and an outer surface of the fixed vane is configured to engage with another roller on the hoistway door. When both the first and second rollers are engaged by the sensing and fixed vanes, the locking apparatus is configured to remove the elevator door latch arm from the catch. |
| US10544004B2 |
Sheet processing apparatus and image forming apparatus having the same
A sheet processing apparatus includes a conveying portion conveying sheets; a stack portion staking the sheets; a first regulating portion regulating a position of a sheet bundle on the stack portion in a crossing direction; a second regulating portion regulating a position of a sheet bundle in the conveying direction; a first binding device moving in the crossing direction so that the first binding device moves between first and second sides of the sheet processing apparatus and to bind an upstream end portion of a sheet bundle by a staple at a plurality of positions in the crossing direction; a second binding device binding an upstream end portion of a sheet bundle, where the second regulating portion has contacted without a staple; and a controller causing, in a case that the first binding device binds a sheet bundle, the second binding device to be positioned outside the sheet bundle. |
| US10543999B2 |
Sheet conveyance apparatus and image forming apparatus
A sheet conveyance apparatus includes a conveyance portion, a reverse conveyance portion, and first and second conveyance regulating portions. An engagement portion contacts the first conveyance regulating portion so that it pivots in a first pivoting direction in an interlocked manner with the second conveyance regulating portion. The first and second conveyance regulating portions are arranged between the conveyance portion and the reverse conveyance portion in a first sheet conveyance direction, and an urging member urges the first and second conveyance regulating portions toward a position where the first and second conveyance regulating portions project to a first conveyance path through which the sheet conveyed from the conveyance portion toward the reverse conveyance portion is conveyed. |
| US10543996B2 |
Sheet feeding apparatus and image forming apparatus
A sheet feeding apparatus includes a sheet supporting portion, a rotary feeding member configured to feed the sheet, a regulating portion configured to regulate a position of the edge portion, and a force applying portion that is provided separately from the rotary feeding member. The force applying portion contacts the sheet supported on the sheet supporting portion upstream in a conveyance direction of the rotary feeding member and applies a force to turn the sheet fed by the rotary feeding member. |
| US10543994B2 |
Stacking apparatus, feeding apparatus, and image forming apparatus
A stacking apparatus includes a first stacking unit, for stacking sheets of a first size, configured to move vertically between an upper limit position and a lower limit position, and a second stacking unit for stacking sheets of a second size larger than the first size in cooperation with the first stacking unit. The second stacking unit is jointed to the first stacking unit at a predetermined position, moving vertically together with the first stacking unit while being joined to the first stacking unit above the predetermined position, and is released from being jointed to the first stacking unit below the predetermined position. |
| US10543989B2 |
Belt conveyor with automated in-line tension control system
A belt conveyor with automatic in-line tensioning. A tensioner bar is slidably received into a tensioning slot and guided by a plurality of rails. At least one air spring is positioned between the tensioner frame and the tensioner bar. The first air spring pushes the tensioner bar such that movement of the tensioner bar moves the end roller to affect a tensioning force upon the endless belt. An air pressure gauge can display an air pressure value corresponding to a tension force of the endless belt. A tracking assembly allows tracking of the endless roller independent of the tensioning. A controller can controls the tensioning and release of tensioning based on operational or environmental factors. |
| US10543988B2 |
Real-time mobile carrier system for facility monitoring and control
Embodiments of a mobile carrier monitoring apparatus are disclosed. The apparatus includes one or more mobile carriers configured to receive items being manufactured in its interior and configured be moved by a transport system to multiple positions within a manufacturing facility. A mobile carrier control system is positioned in the interior or on the exterior of each mobile carrier, as are one or more sensors that are coupled to the mobile carrier control system. A communication system is positioned in the interior or on the exterior of each mobile carrier and communicatively coupled to the at least one sensor and to the mobile carrier control system, and an electrical power system positioned in the interior or on the exterior of each mobile carrier and coupled to deliver electrical power to the mobile carrier control system, to the one or more sensors, and to the communication system. Other embodiments are disclosed and claimed. |
| US10543986B1 |
Roller belt conveyor
The present disclosure relates to a roller belt conveyor having an array of pivot rollers defining a conveyance surface that supports an article being conveyed in a first conveying direction, at least one drive plate pivotally coupled to at least a subset of the array of pivot rollers, and an actuator coupled to the at least one drive plate, such that, the actuator may manipulate the at least one drive plate to adjust an angular orientation of the at least one subset of the array of pivot rollers from the first conveying direction to a second conveying direction. |
| US10543983B2 |
Dual-axis vertical displacement and anti-rock support with a materials handling vehicle
A variety of vehicle-based and warehouse-based solutions are provided to increase the adaptability, utility, and efficiency of materials handling vehicles in the warehouse environment, such as a materials handling vehicle comprising a picking attachment is secured to a fork carriage assembly and comprising an X-Y-Z-Ψ positioner to engage and disengage a target tote such that movement of the picking attachment along a Z axis by the X-Y-Z-Ψ positioner is independent of movement of the fork carriage assembly along the vertical axis Z′ by the mast assembly and mast assembly control unit. The fork carriage assembly may comprise a mobile storage cart support platform defined by one or more cart lifting forks, and an anti-rock cart engagement mechanism configured to engage a mobile storage cart supported by the cart lifting forks. |
| US10543977B2 |
Pressure regulated beverage cartridges
Various embodiments of pressure regulated beverage cartridges are disclosed. In some embodiments, a system includes a cartridge and a beverage preparation machine. The cartridge and machine can be configured such that, when the cartridge is received in the machine, a pressure of less than a limit value is maintained in the cartridge during the beverage preparation process, which can improve the flavor of certain beverages, such as brewed coffee beverages. |
| US10543964B2 |
Container with a lid and a securing ring
A container includes a container body and a lid, which has an outer lid wall portion surrounding a central portion. The outer lid wall portion provides a lid-side sealing surface, which engage with body-side sealing surface, when the lid is applied to the container body to close the container. The container further includes a securing ring inserted within the outer lid wall portion. The securing ring having a lower portion and an upper flange portion extending from the lower portion at an acute angle (α) of less than 80° from vertical. |
| US10543963B2 |
Closure comprising a pierceable part and container provided with such closure
A closure having a base with a piercable part, defined by a sidewall extending transversally with respect to the base and a bottom thereby creating an indent therein, the sidewall and/or bottom provided with several lines of weakened material strength, wherein the lines divide the sidewall and/or bottom in several wedge formed parts. |
| US10543956B2 |
Dispenser and process
A dispenser (10) for dispensing flowable materials has a container (12) having an outer wall (20), a dividing wall (21) and a membrane (14) operably connected to define a first chamber (22), a second chamber (24) and a third chamber (16). The dividing wall (21) is connected to the membrane (14) at an interface (30). The first chamber (22) defines a first volume and is configured to contain a first flowable material (M1), and the second chamber (24) defines a second volume and is configured to contain a second flowable material (M2). The membrane (14) has a first section (34) having a first rupturable member (40) and a second section (36) having a second rupturable member (40). The first section (34) is separated from the second section (36) by the interface (30). The third chamber (16) is positioned adjacent the membrane (14) generally opposite the first chamber (22) and the second chamber (24), wherein the third chamber (16) defines a third volume and is configured to receive the first flowable material (M1) and the second flowable material (M2) upon rupture of the first rupturable member (40) and the second rupturable member (40) wherein a mixture (MX) is formed. The first volume and the second volume are collectively approximately equal to the third volume. |
| US10543955B1 |
Dispenser for eye shields
Disclosed is an eye shield dispenser. The dispenser has a front panel, a rear panel, first and second front side panels, first and second rear side panels, a top panel, and a bottom panel. The front panel includes an access port providing access for removal of eye shields contained therein. An optional inclined surface is disposed in the interior of the dispenser near the access port, and eye shields are configured to be placed thereon and manually removed therefrom. The dispenser is shaped to generally correspond with the shape of the eye shields to hold the eye shields in place such that an inner insert is not required. |
| US10543954B2 |
Method and blanks for forming a shelf-ready display container
A container formed from a blank and a method for constructing the container are described. The container includes a shell and a liner disposed substantially within the shell. The shell includes a bottom wall, two opposing end walls including a first and well and a second end wall, and two opposing side walls including a first side wall and a second side wall. The shell further includes a plurality of top panels extending from a top edge of each of the first end wall, the second end wall, the first side wall, and the second side wall. |
| US10543949B2 |
Foldable crate system
A foldable crate system, associated methods, and an associated apparatus are provided. The foldable crate system includes a continuous piece of paperboard having machined fold lines therein. The machined fold lines allow for highly precise folds of the paperboard to form the same into a packaging unit. |
| US10543946B2 |
Sheet of packaging material for producing a container and method for producing containers
A sheet of packaging material to form a package, comprises a receiving region to receive an opening device of the package attached thereon, the sheet of packaging material further comprises two reference marks detectable by a detecting unit of an applying device arranged for applying the opening device on the receiving region. A method for producing a package comprises folding, filling and sealing a sheet of packaging material to obtain the package, the packaging material comprising a receiving region to receive an opening device and two reference marks, the method comprising detecting the reference marks and selecting a subsequent action to be performed on the package and/or the opening device on the basis of the detected position of the reference marks. |
| US10543939B2 |
Apparatus and methods for creating artificial near-earth orbits
An orbiting satellite can be maintained in a virtual orbit, having an orbital period equal to the natural orbit of a satellite at a different altitude, by equipping the satellite with at least one radial thruster. Radial thrusters on the anti-nadir-facing side of the satellite allow for virtual orbits higher than the natural altitude, while radial thrusters on the nadir-facing side of the satellite allow for virtual orbits lower than the natural altitude. This allows a satellite to evade threats, such as orbital debris and/or hostile spacecraft, without losing its relative position within a satellite constellation or experiencing the diminished services often attendant such maneuvers. Similar techniques can also be used for surveillance of orbiting satellites. |
| US10543933B1 |
Aircraft lighting system
A method, apparatus, and system for automating detection and avoidance for an aircraft. A process activates a set of lamps visible on an exterior of an aircraft to emit light. The process modulates an intensity of light from the set of lamps at a set of frequencies that is detectable by a remote collision avoidance system in a remote aircraft during flight. The light from the set of lamps at the set of frequencies is perceived as continuous by a person looking at the aircraft in a sky, reducing visibility of the aircraft in the sky. |
| US10543928B2 |
Electric power distribution system for an aircraft
An electric power distribution system for an aircraft is provided, which includes an engine gearbox, a power distribution center, two or more three-phase synchronous electric power generators, a neutral current transformer per generator, a single set of power feeder wires, and a single generator control unit (GCU). The generators are connected in parallel with each other, and connected with the power distribution center by the same set of power feeder wires. The GCU is electrically coupled with each generator to feed the generator with an excitation field current, and with each neutral current transformer to sense an instantaneous neutral-current value. The GCU is adapted to perform a generator voltage regulation loop based on a desired voltage value and the at least two sensed instantaneous neutral-current values by individually modifying the excitation field current of each generator. |
| US10543924B2 |
Environmental control system utilizing multiple mix points for recirculation air in accordance with pressure mode
A system is provided. The system includes an air conditioning pack; a first medium; a second medium; a first mixing point located outside the air conditioning pack and configured to mix the first medium with the second medium; and a second mixing point located inside the air conditioning pack and configured to mix the first medium with the second medium. |
| US10543922B2 |
Flight attendant seat, system comprising flight attendant seat as well as arrangement and aircraft area comprising system
A flight attendant seat comprises a carrier having a guide with opposed first and second ends, and a storage compartment receiving the guide first end. The guide provides guidance along its length between its first and second ends. The seat comprises a plurality of segments, each slidingly mounted to the guide to allow a sliding movement of the segments along the guide and relative to the carrier device between a stored position of the segments within the storage compartment, and an exposed position of the segments. A seat element is pivotally mounted to a first of the segments pivotable between an inoperative and operative seat forming position. At least one backrest is mounted to at least a second of the segments. With the segments in their exposed position, the seat element, when pivoted to its operative position, together with the backrest(s), can be used as a flight attendant seat. |
| US10543921B2 |
Lightweight seat
Disclosed is a lightweight seat (100) that includes a seat base (102), a seat bottom (103) attached to an upper portion of the seat base, a seat back (101) attached to a rear portion of the seat bottom, and a seat belt assembly (150) secured to the seat bottom. The seat belt assembly may include a strap (104) attached to an underside of the seat bottom and extending from a first end adjacent to first side of the seat bottom to a second end adjacent to a second side of the seat bottom and a seat belt disposed adjacent to an upper side of the seat bottom, wherein a first end of the seat belt is attached to the first end of the strap and a second end of the seat belt is attached to the second end of the strap. |
| US10543917B2 |
Flying drone comprising two wings in tandem to which photovoltaic cells are coupled
A flying drone, which includes a fuselage; a propulsion powered at least by electrical accumulators and/or photovoltaic cells; and first and second wings. The first wing is defined by a wingspan and by an upper surface area, where the upper face of the first wing is essentially covered by photovoltaic cells. The second wing has practically the same wingspan and upper surface area as the first wing. The second wing is offset along the fuselage and in height relative to the first wing. The upper face of the second wing is essentially covered with photovoltaic cells. |
| US10543912B2 |
Higher harmonic control augmented with active vibration control
A rotary wing aircraft includes a rotor system rotatable about an axis relative to an airframe. A plurality of blade assemblies is mounted to the rotor system. A higher harmonic control system is operable to generate a harmonic load at the rotor system according to a higher harmonic control signal. An active vibration control system is operable to generate vibration forces about the aircraft according to an active vibration control signal. A controller is operable to issue the higher harmonic control signal and the active vibration control signal to coordinate the higher harmonic control system and the active vibration control system to reduce vibration within the airframe. |
| US10543907B2 |
Flow control technique by dielectric materials
A multilayered active surface is presented whose rugosity can be controlled by an applied electrical field. Varying the applied electrical field can control the rugosity of the surface which makes contact with a fluid, and thereby can affect instabilities of the boundary layer. A middle layer of the multilayered active surface can be made of a compliant electroactive material. In some cases, a pre-stretch in the middle layer can predefine a rugosity of the multilayered active surface without an applied electrical field, in which case an applied electrical field can further alter the rugosity in both amplitude and spatial periodicity and ultimately result to a smooth surface for a higher value of the applied electrical field. A top layer and a bottom layer are constructed using conductive material and uses as electrodes coupled to a voltage source to generate the electric field that controls the rugosity of the surface. |
| US10543906B1 |
Temperature management systems for aerial vehicles
Temperature management systems for aerial vehicles may include heat pipes that are thermally connected to components that generate heat. The heat pipes may be routed through or adjacent to a propeller or propulsion airflow, or within or across a vehicle airflow, to dissipate heat from the components. A heat pipe may be selected from a plurality of heat pipes based on measured temperatures of components that generate heat, operational characteristics of the aerial vehicle and/or one or more propellers, and/or measured temperatures of other components that may be heated. Additional temperature management systems may include cool air ducts and cool air pipes that may be routed from a propeller or propulsion airflow, or a vehicle airflow, to components that generate heat or other components that may be cooled. |
| US10543903B2 |
Actuators for high lift devices on aircraft
Actuators for high lift devices on aircraft are disclosed herein. An example apparatus includes an actuator for a high lift device of an aircraft including a motor and a transmission, where the transmission includes a first gear stage and a second gear stage, the first gear stage including a first worm gear and the second gear stage including a second worm gear, the first worm gear, the second worm gear and the motor operative to prevent backdrive of the actuator. |
| US10543902B2 |
Laser reflection aerodynamic control surface movement monitoring system
An actuator system for controlling a flight surface of an aircraft includes a first actuator having a first actuator input and a first linear translation element that moves based on rotational motion received at the first actuator input and a first laser distance sensor disposed inside the first actuator that generates a first output based on a displacement of the first linear translation element. The system also includes a second actuator having a second actuator input and a second linear translation element that moves based on rotational motion received at the second actuator input and a second laser distance sensor disposed inside the second actuator that generates a second output based on a displacement of the second linear translation element. The system also includes a control unit that receives the first and second outputs and determines if an error condition exists for the system based on first and second output. |
| US10543901B2 |
System and method for controlling propeller pitch
Systems and methods are disclosed for controlling the pitch angle of a propeller and rotor assembly that selectively limit the pitch angle according to a selected mode of operation. The system comprises a fine stop collar defining a primary channel, an oil transfer bearing (OTB) extending across the fine stop collar, and an actuator piston engaged with a propeller blade crankshaft to vary propeller blade pitch, wherein the annular piston is positioned about the OTB in fluid communication with the primary channel. |
| US10543897B2 |
Systems for shape memory alloy structures
There is provided a training system capable of performing work. The system has a shape memory alloy (SMA) actuator exhibiting a generally planar transformational behavior. The system further has one or more heating elements for transforming the SMA actuator from an original shape to a trained shape, thereby performing work. |
| US10543895B1 |
Hydraulic steering system for a watercraft
A steering system for a watercraft has steering position sensors sensing a steering position of first and second outboard motors, hydraulic steering actuators for steering the outboard motors, a hydraulic helm selectively supplying hydraulic fluid to the steering actuators, at least one valve for reversing a direction of flow of hydraulic fluid into the steering actuators, and a steering controller. The steering controller executes a realignment process including: receiving signals indicative of the steering positions of the outboard motors from the steering position sensors; based at least in part on the signals, determining if the outboard motors are misaligned; and, if the outboard motors are misaligned, actuating the at least one valve to direct the flow of hydraulic fluid into a corresponding steering actuator in a direction opposite to that corresponding to an active steering direction set by the hydraulic helm so as to reduce misalignment of the outboard motors. |
| US10543890B2 |
Marine lifting apparatus
A catamaran lifting apparatus is disclosed for lifting objects in a marine environment. The apparatus includes first and second vessels that are spaced apart during use. A first frame spans between the vessels. A second frame spans between the vessels. The frames are spaced apart and connected to the vessels in a configuration that spaces the vessels apart. The first frame connects to the first vessel with a universal joint and to the second vessel with a hinged connection. The second frame connects to the second vessel with a universal joint and to the first vessel with a hinged or pinned connection. Each of the frames extends upwardly in an inverted u-shape, providing a space under the frame and in between the barges that enables a marine vessel to be positioned in between the barges and under the frames. |
| US10543887B2 |
Dock handrail and gate apparatus
A dock handrail gate includes a base plate installable on the surface of the dock and a post mounted to the base plate perpendicular to the base plate. The handrail also has a rail that attaches to the top portion of the post and extends horizontally and inclines downwardly at an angle inwardly towards the post and further attaches to the bottom portion of the post. The handrail may also have an inner tube that includes an inner sleeve to allow the post and the rail to be lifted and rotated to lock into one or more positions. |
| US10543885B2 |
Multi axis suspension vessel
A vessel with three platforms—an outer hull, an inner deck hull and a passenger carriage, having four independent suspension systems there between so as to accommodate for the multi axis movements of the outer hull. This multi axis suspension system spread between the three platforms will offer the passenger carriage stability against the pitch, yaw and roll rotations a vessel makes as it twists and turns going up and down the slope of a wave as well as the heave, sway and surge movements induced by the waves pushing the vessel around and or the ship sliding down the face of a wave. |
| US10543884B2 |
Bicycle operating device
A bicycle operating device is basically provided with a base member, a positioning ratchet, a first positioning pawl and a second positioning pawl. The positioning ratchet pivots with respect to the base member about a pivot axis. The positioning ratchet pivots in first and second directions. The first and second positioning pawls are pivotally mounted about a pawl pivot axis between holding positions and releasing positions. The first and second positioning pawls include contact points that selectively contact the positioning ratchet to prevent pivoting of the positioning ratchet in the first direction while the holding position. The contact points of the first and second positioning pawls are perpendicularly spaced from the pawl pivot axis by first and second linear lengths, respectively, that are different. The pivot axis and the pawl pivot axis defines a plane. The first and second contact points are located on a same side of the plane. |
| US10543883B2 |
Speed change apparatus for vehicle
In a speed change apparatus for a vehicle, a controller stores as a clutch-disengaging shift spindle angle θ1 a position at which a clutch is disengaged when a shift spindle is rotated in a first direction. The controller controls the shift spindle by a first step W1 of rotating the shift spindle in the first direction until a disengaging-side target angle Ta1 is reached; a second step W2 of returning the shift spindle in a second direction opposite to the first direction; and a third step W3 of rotating the shift spindle in the first direction up to the clutch-disengaging shift spindle angle θ1 and thereafter rotating the shift spindle in the second direction to return the shift spindle, upon detection of an output from a drum angle sensor, the output corresponding to shallow engagement of dog teeth. |
| US10543870B1 |
Hitch assist system
A hitch assist system is provided herein that includes a sensing system configured to detect a trailer proximate a vehicle. A steering system is configured to alter a path of the vehicle. A transmission system has one or more gears therein. A controller is disposed within the hitch assist system and is configured to control the steering system of the vehicle along a path to align a hitch ball with a coupler of the trailer, detect a fault of the steering system or a gear change in the transmission system and pausing the control of the vehicle, and monitor the coupler during repositioning of the vehicle. |
| US10543853B2 |
Systems and methods for providing collaborative control of a vehicle
System, methods, and other embodiments described herein relate to providing collaborative controls for a vehicle. In one embodiment, a method includes, in response to receiving manual inputs and autonomous inputs for controlling the vehicle, determining a difference between the manual inputs and the autonomous inputs. The method includes blending the manual inputs and the autonomous inputs together into the collaborative controls as a function of at least the difference, and feedback parameters to control the vehicle to proceed along a route. The method includes generating feedback according to at least the difference to adapt how the vehicle is controlled. |
| US10543852B2 |
Environmental driver comfort feedback for autonomous vehicle
Described herein is an autonomous vehicle comprising a sensor and a driver notification module in communication with the sensor. The driver notification module may be configured to receive first information related to an upcoming event; determine an action for an autonomous vehicle based, at least in part, on the first information; determine one or more characteristics of the action based, at least in part on the first information and a current status of the autonomous vehicle; determine a notification based, at least in part, on the action and the one or more characteristics; and deliver the notification within the autonomous vehicle. |
| US10543851B2 |
Parking assistance system with universal parking space detection
A parking assistance system executes a process to measure the parking space by a sensor prior to carrying out an automated parking maneuver and to detect the parking space type from a plurality of detectable parking space types using specific criteria on the basis of the measurement of the parking space. The plurality of parking space types includes a longitudinal parking space type, in which a vehicle can park longitudinally, a transverse parking space type, in which a vehicle can park transversely, and a universal parking space type in which the vehicle can park both longitudinally as well as transversely. In the event that the parking space has been detected as a universal parking space type, the parking assistance system provides the driver with the choice to select a parking direction, namely whether the parking assistance system is to park longitudinally or transversely into the parking space. The parking assistance system parks the vehicle into the parking space longitudinally or transversely according to the selection of the driver, wherein the parking trajectory depends on the selection of the driver. |
| US10543850B2 |
Reactivation of driver assist mode
A computer that includes a processor and memory. The memory may store instructions executable by the processor. The instructions may include: following a driver-initiated trigger to deactivate a driver assist mode, to reactivate the mode when, for a dwelling period, each of a plurality of conditions equal respectively predetermined value. |
| US10543848B2 |
Method and system for vehicle ESC system using map data
An Electronic Stability Control (ESC) system for a vehicle is disclosed. An electronic control unit (ECU) is programmed to reduce vehicle lateral skidding by reducing differences between an intended vehicle direction and/or yaw rate and an actual vehicle direction and/or yaw rate by applying modifications to operation of the vehicle brakes and/or throttle. The ESC system receives inputs from wheel speed sensors, a steering wheel position sensor, a yaw rate sensor and a lateral acceleration sensor. The ESC system also receives input that indicates at least a property of the road upon which the vehicle is located, wherein the road upon which the vehicle is located is determined from a positioning system that uses a map database and the property is determined from the map database. The ESC system incorporates the road property information in determining when and/or how to modify operation of the vehicle to reduce vehicle skidding. |
| US10543847B2 |
Contextual driver behavior monitoring
A database of high risk locations is formed and high risk causal factors for the high risk locations determined. Driver behavior is monitored at the sites in the database using data collection devices such as electronic logging devices or mobile phones to see if the drivers exhibit the same specific behaviors that are considered contributing factors to specific accident types at risk of occurrence at those sites. Warnings are provided to drivers approaching the specific sites to prompt behavioral changes which may further be monitored by the data collection devices. |
| US10543843B2 |
Work vehicle
This work vehicle (tractor), which is provided with an engine and an accelerator pedal capable of changing the operational state of the engine, and is configured to be free to travel by means of an operation of the accelerator pedal by an operator, is equipped with a display near an operator's seat, said display being configured to be capable of displaying a screen (travel customization screen) for selecting whether or not to allow travel in conjunction with the accelerator. |
| US10543842B2 |
System and method for generating vacuum via an engine
Methods and systems for improving vacuum generation for an engine that may be operated at higher altitudes are presented. In one non-limiting example, a transmission that is mechanically coupled to the engine may be shifted from a gear to neutral in response to an actual total number of times a vehicle brake pedal is applied and partially released while the vehicle is stopped and the brake pedal is applied. |
| US10543841B2 |
Vehicle with autonomous driving capability
A vehicle with autonomous driving capability is adapted for at least two different driving modes including a first driving mode configured for a first type of autonomous driving and a second driving mode configured for the autonomous vehicle being guided by a pilot vehicle in such a manner that the autonomous vehicle follows the pilot vehicle. |
| US10543838B2 |
Robotic vehicle active safety systems and methods
Systems and methods implemented in algorithms, software, firmware, logic, or circuitry may be configured to process data and sensory input to determine whether an object external to an autonomous vehicle (e.g., another vehicle, a pedestrian, road debris, a bicyclist, etc.) may be a potential collision threat to the autonomous vehicle. The autonomous vehicle may be configured to implement active safety measures to avoid the potential collision and/or mitigate the impact of an actual collision to passengers in the autonomous vehicle and/or to the autonomous vehicle itself. Interior safety systems, exterior safety systems, a drive system or some combination of those systems may be activated to implement active safety measures in the autonomous vehicle. |
| US10543837B2 |
Mitigating bodily injury in vehicle collisions by reducing the change in momentum resulting therefrom
Methods, systems, and computer program products are described herein for automatic collision avoidance and/or bodily injury mitigation. For example, a vehicle determines the optimal action(s) to take to avoid a collision or reduce the bodily injury of occupant(s) of the vehicle in the event that the vehicle determines that the collision is unavoidable. The vehicle performs action(s) that reduce the change of momentum experienced by occupant(s) thereof as a result of the collision. The actions are based on various characteristics of the vehicles that are to be involved in the collision. Such actions may comprise accelerating into and causing a collision with vehicle(s) in front of the vehicle at or around the same time at which a further vehicle rear-ends the vehicle. The system processes several scenarios in real-time (taking into changes of velocity of the vehicles involved) to determine the scenario that best mitigates the change of momentum. |
| US10543834B2 |
Method for operating a drive device for a motor vehicle and corresponding drive device
A method for operating a drive device for a motor vehicle, which has an internal combustion engine and an electric motor. A drive shaft of the internal combustion engine can be coupled to a motor shaft of the electric motor by a shift clutch. The shift clutch is adjusted to a desired clutch torque over a dragging period for startup of the internal combustion engine. Prior to the startup, a quantity of heat that is expected to accrue in the shift clutch during the startup is predicted and, when the predicted quantity of heat exceeds a limit value, at least one operating parameter of the drive device that influences the startup is chosen in such a way that the quantity of heat expected to accrue is reduced. |
| US10543832B2 |
Methods and systems for starting an engine
Methods and systems are provided for improving engine restart operations occurring during a transmission shift in a hybrid vehicle. Engine speed is controller during cranking and run-up to approach a transmission input shaft speed that is based on the future gear of the transmission shift. Engine speed is controlled via adjustments to spark, throttle, and/or fuel, to expedite engine speed reaching the synchronous speed. |
| US10543830B2 |
Control strategy for plug-in hybrid electric vehicle
A method of controlling a plug-in hybrid electric vehicle including an electric propulsion system, an engine, and a catalytic converter associated with the engine, the method comprising: monitoring a state of charge of a battery of the vehicle when in a charge depletion mode; determining a rate of depletion of the state of charge; estimating from the rate of depletion a duration of a depletion period representing the time remaining until a minimum state of charge of the battery will be reached; determining a duration of a warming period of the catalytic converter; comparing the duration of the depletion period and the duration of the warming period; and activating the engine if the duration of the depletion period is less than or equal to the duration of the warming period. |
| US10543826B2 |
Valve system and method for controlling same
A valve system includes an isolation check valve delivering pneumatic fluid as a supply pressure, a double-check valve adapted to deliver a braking demand control signal of the pneumatic fluid based on a higher of a first braking demand in a first pneumatic braking circuit and a second braking demand in a second pneumatic braking circuit, and a control module. The control module is adapted to receive the supply pressure as a control module supply pressure of the pneumatic fluid, receive a control module control pressure of the pneumatic fluid based on the braking demand control signal, and deliver a control module delivery pressure of the pneumatic fluid based on the control module supply pressure and the control module control pressure. A park control module selectively transmits the pneumatic fluid at the supply pressure based on a park brake control signal. |
| US10543824B2 |
Braking device for a hydraulic motor vehicle brake system
A modular braking device for a hydraulic motor vehicle brake system, which is optimized for remote actuation, including a hydraulic booster stage with a booster housing, a main brake cylinder mounted thereon, a booster piston which is displaceable therein and delimits a pressure chamber which is supplied directly with pressure medium by a motor pump unit. |
| US10543822B2 |
Method of and apparatus for controlling vehicle braking
A method of controlling deceleration of a vehicle which includes the steps of sensing the speed of rotation of the output shaft and generating an output shaft speed signal. The method also includes deriving from the output shaft speed signal a deceleration signal indicative of deceleration of the vehicle, and generating in accordance with a selectively effective feedback control scheme a braking command. The method further includes using the output shaft speed signal to calculate a maximum braking power signal and modulating the braking command in dependence on the maximum braking power signal in order to limit the braking power applied in the SAHR brake. The maximum braking power signal is determined in dependence on the heat dissipating capacity of the SAHR brake and is such as to give rise to a constant or approximately constant value of braking power dissipated in the SAHR brake. |
| US10543820B2 |
System and method for braking a vehicle
A vehicle braking system for a vehicle combination includes a first brake axle including a first actuatable brake, a second brake axle including a second actuatable brake, a third brake axle including a third actuatable brake, a first valve controlling actuation of the first actuatable brake and actuation of the second actuatable brake, and a second valve controlling actuation of the second actuatable brake and actuation of the third actuatable brake. |
| US10543814B2 |
Heated and illuminated wiper assembly
A wiper assembly includes a wiper arm, a wiper blade carried on the wiper arm and a light source provided between the wiper arm and the raised wiper blade. The wiper assembly may also include a heating element and a controller to control operation of the light source and the heating element. |
| US10543813B2 |
Wiper blade
A wiper blade is presented having a wiper strip, a primary frame, and a pair of secondary frames. The primary frame having a connection device capable of connecting the wiper blade to a wiper arm disposed on a top side of the primary frame, and a connection structure disposed, on opposite ends of the primary frame. The pair of secondary frame, each have a central pivot connection portion and two leg portions extending from the central pivot connection portion, a pivot structure disposed on the central pivot connection portion of the secondary frames wherein the pivot structure of the secondary frames are connected to the connection structures on the ends of the primary frame. A wiper blade is also presented having a wiper strip, a force distribution structure having opposite ends, and a cover. |
| US10543812B1 |
Vehicle sensor
A system includes an optical fiber embedded in a windshield. The system includes a reflector embedded in the windshield and oriented to reflect light to a first end of the optical fiber. The system includes a sensor oriented to receive light from a second end of the optical fiber. |
| US10543810B2 |
Authorizing the use of a motor vehicle
A motor includes at least a first and a second antenna, wherein the antennas are arranged spaced apart spatially from one another, by means of a portable identification signal generator which has an identification signal generator antenna. In order to improve the protection against tampering, the first vehicle antenna outputs a first signal which is received by the identification signal generator antenna. The identification signal generator determines at least one of the spatial components of the first electromagnetic field of the received first signal. The second vehicle antenna outputs a second signal which is received by the identification signal generator antenna. The identification signal generator determines at least one of the spatial components of the second electromagnetic field of the received second signal. The identification signal generator transmits the data to the vehicle. A computer determines the angle at least between the special components of the signals. |
| US10543807B2 |
Energy absorbing restraint system
A restraint system includes a housing defining a cavity tapering to an end and a plug disposed in the cavity. The plug is larger than the end of the housing. A seatbelt buckle is fixed relative to one of the housing and the plug and is moveable from a first position to a second position relative to the other of the housing and the plug. The plug is moveable relative to the housing toward the end during movement from the first position to the second position. One of the housing and the plug is plastically deformable by the other of the housing and the plug during movement from the first position to the second position. |
| US10543806B2 |
Seatbelt assembly
A seatbelt assembly that includes a tongue assembly having a weblock mounted to a tongue selectively securable to a buckle; a webbing extends through the weblock between a torso portion and a lap portion; and with the weblock allowing for the webbing to slide between the torso and lap portions when in an unlocked position and pivoting relative to the tongue when in a locked position to reorient the torso portion extending from the tongue. |
| US10543805B2 |
Side airbag device
A side airbag device includes: an airbag which is stored in a storage part provided on a side of an occupant sitting on a seat of a vehicle in a normal posture, and is deployed and inflated forward between the occupant and a side wall part by an inflation gas supplied from a gas generator in response to an impact applied from a side to the side wall part of the vehicle; an exhaust port configured to exhaust an inflation gas, the exhaust port being provided with the airbag and open toward a direction along a wall surface of the side wall part; and an opening varying mechanism configured to reduce an opening area of the exhaust port in a later stage of deployment and inflation of the airbag compared to an initial stage. |
| US10543801B2 |
Airbag for vehicle
An airbag for a vehicle includes an airbag cushion and a tether. The airbag cushion is installed on one side of a seat and is composed of multiple chambers. When the airbag is deployed, the airbag cushion extends to a front side of the seat and the chambers are consecutively arranged in a superior-inferior direction of the seat. The tether connects the chambers to each other or connects one chamber to a vehicle body. The multiple chambers include a normal chamber deployed to the front side of the seat and a confining chamber bent toward an occupant when being deployed. The confining chamber is pressed by the adjacent normal chamber, or pulled or pressed by the tether. Thus, a front half portion of the confining chamber is folded toward a rear half portion of the confining chamber, thereby coming into tight contact with the occupant. |
| US10543799B1 |
System and method for isolating and accessing potentially hazardous personal devices
A system for protection from potentially hazardous personal devices includes a passenger interaction console co-located proximate to a passenger seat of a vehicle and usable by a user seated at the passenger seat, an isolation chamber configured to store a potentially hazardous personal device, an access control module configured to confirm that the user is authorized to use the potentially hazardous personal device and enable the user to access the potentially hazardous personal device in response to confirming that the user is authorized to use the potentially hazardous personal device. A corresponding method includes determining a passenger seat location for a user, accessing seat assignment information for the user, confirming that user is assigned to the passenger seat location, and enabling the user to access a potentially hazardous device stored within an isolation chamber corresponding to the passenger seat. |
| US10543796B2 |
Protection device for vehicle electrical component
Provided is a protection device for a vehicle electrical component capable of preventing damage to a predetermined electrical component due to hitting by a battery, and also capable of reducing noise/vibration. The disclosure is a protection device which protects a starter in a vehicle in which a battery and the starter are disposed to face each other with a space therebetween in an engine room of the vehicle in which components constituting a power plant or a power train are supported by a vehicle body via a mount and a bracket. The skid block serving as the protection device includes bracket attachment portions attached to a transmission attachment portion of the bracket, and a skid block main body extending upward from the bracket attachment portions and gradually away from the bracket extension portion, and having a distal end portion positioned between the battery and the starter and facing the battery. |
| US10543795B2 |
Battery module connector barrel
A battery module includes a housing having a wall. The wall includes an opening extending from an inner surface of the wall facing an interior of the housing to an outer surface of the wall opposite to the inner surface. The battery module also includes a connector barrel having a first open end, a second open end, and a body portion extending between the first and second open ends. The body portion is positioned within the opening of the wall, the first open end is positioned within the interior of the housing, and the second open end is positioned external to the housing. A ridge on the body portion is disposed proximate to the outer surface of the wall, and a first circumferential bump on the body portion is disposed proximate to the inner surface of the wall. The battery module also includes a securement component disposed within a space defined by the first circumferential bump of the connector barrel. The wall is sandwiched between the ridge of the connector barrel and the securement component. |
| US10543790B2 |
Modular rack system with gussetless joints
A modular rack system, for adjustably attaching equipment to a vehicle, includes a base mountable on a side wall of the vehicle. The rack system has a first wall that is disposed on and upwardly emanating from the top surface of the base that defines a lower seat. One end of a vertical member resides in the lower seat and is secured thereto. The other end of the vertical member resides in a upper seat defining by a downwardly depending wall from a saddle and is secured thereto. The first and second walls laterally stabilize the vertical member relative to the base and saddle to permit the base to be mounted to a side wall of a vehicle and a top rail to be secured to the saddle without the use of gussets or cross-braces. |
| US10543788B2 |
Deployable rear view mirror mobile device holder
A mobile device holder for a rear-view mirror of a vehicle may include a mirror housing and a mobile device bracket arranged at least partially therein in a stored position, and a deployment mechanism connected to the bracket and including a torsion spring configured to rotatedly hinge the bracket from the stored position to a deployed position extending out of the housing in response to actuation of the torsion spring. |
| US10543787B2 |
Full display mirror with rack-and-pinion actuator
A rearview mirror for a vehicle includes a housing defining an interior cavity and an open side, a substrate rigidly coupled within the open side of the housing and having a reflective surface thereon, and an actuation mechanism coupled within the housing. The actuation mechanism has a mounting plate rotatably coupled within the cavity of the housing at a first end of the mounting plate, a first gear rack being defined on a second end of the mounting plate, and a motor rigidly coupled within the interior cavity of the housing adjacent the second end of the mounting plate. The motor has a first pinion gear coupled with an output shaft thereof and in a mesh engagement with the gear rack. |
| US10543786B2 |
Vehicle camera system
A vehicular camera system includes a black-out layer disposed at an upper central region of a windshield as installed in a vehicle, an attachment member configured for attachment at the upper central region of the windshield where the black-out layer is disposed, and an accessory module including a camera. The accessory module is configured to detachably mount at the attachment member at the windshield such that the lens of the camera is spaced from the windshield, and such that the camera views forward of the vehicle through an aperture in the black-out layer via a tapered structure that is widest at the windshield and that tapers from the windshield towards where the lens of the camera is located. The tapered structure is at an acute angle relative to the vehicle windshield. The camera captures image data for a driver assistance system of the equipped vehicle. |
| US10543784B2 |
Rearview mirror assembly for vehicle
An exterior rearview mirror assembly for a vehicle includes a mirror head and a light module disposed at a mirror casing. A blind zone indicator light emitting diode and a turn signal indicator light emitting diode are disposed at a single circuit board and are operable to emit light for a blind zone indicator and a turn signal indicator, respectively. The blind zone indicator and the turn signal indicator are disposed along a forward and sideward portion of the mirror casing, where the turn signal indicator is viewable and the blind zone indicator is not viewable along the forward and sideward portion of the mirror casing. When the blind zone indicator light emitting diode is operated and when the exterior rearview mirror assembly is attached at the side of the vehicle, the blind zone alert is viewable by the driver of the vehicle outboard of the mirror reflective element. |
| US10543782B2 |
Cutting tool visual trajectory representation system and method
A machine includes a work implement and at least one camera arranged to capture a video image of a viewed area and provide a video signal related to the viewed area to a controller. The controller compiles a visual display in which the current position and a current direction of the work implement relative to the viewed area is displayed in real time. The controller also calculates a trajectory of the work implement based on machine speed and steering signals to compile a visual trajectory representation of the work implement relative to the viewed area, which is combined with the visual display into a combined visual representation that is presented to an operator through a video display. |
| US10543778B2 |
Light assembly for vehicle and method of using the same
A light assembly for a motor vehicle according to an exemplary aspect of the present disclosure includes, among other things, a light source and a lens arrangement. The lens arrangement includes a collimator having an inner surface adjacent the light source and a flat, planar outer surface. This disclosure also relates to a motor vehicle including the subject light assembly, and a method of using the light assembly. |
| US10543777B2 |
Exterior compartment light
An apparatus, according to an exemplary aspect of the present disclosure includes, among other things, a handle movable relative to a vehicle closure panel between an active mode and a stowed mode, and an illumination source incorporated into the handle. The illumination source illuminates the handle when in the active mode and illuminates a cargo area associated with the vehicle closure panel when in the stowed mode with the closure panel open. A method according to an exemplary aspect of the present disclosure includes, among other things, moving the handle relative to the vehicle closure panel between the active and stowed modes, illuminating the handle when in the active mode, and illuminating the cargo area when in the stowed mode. |
| US10543774B2 |
Adjustment device for adjusting the position of at least one light module in the housing of a headlight
An adjustment device for adjusting a position of at least one light module in a housing of a headlight, with a rotary member for at least indirectly transmitting a rotary motion to the at least one light module, wherein the rotary member at least at one point is guided through an opening in the housing and wherein for sealing the housing against the rotary member, an elastic sealing member is provided against an annular surface bordering the opening, which bears against the housing. To reduce the friction between the sealing member and the annular surface, the sealing member comprises a non-elastic annular element which is provided for abutment against the annular surface. |
| US10543773B2 |
Cargo control cinch strap system
A cinch strap system for securing cargo to a dolly or other type of hand truck having a first and second strap. The first strap has opposing first and second loop ends. A first loop is on the first loop end of the first strap and secures at least two rings to the first strap. A second loop is on the second loop end of the first strap. The second strap is of longer length than the first strap and includes a second strap loop on one end of the second strap. The end of the second strap opposing the second strap loop is a free end. |
| US10543772B1 |
Strap securing device
A strap securing device and method for securing a free end of a strap to a metallic surface including an upper jaw, a lower jaw, and a leverage arm is disclosed. One of either the lower jaw or the upper jaw has a jagged contour and a magnetic surface. The upper jaw and the lower jaw are secured together through the leverage arm, which pinches the free end of a strap between the upper and lower jaws. The magnetic surface allows for attachment of the strap securing device to a metallic surface, such as the surface of a truck bed. |
| US10543770B2 |
Receiving device for beverage containers
A receiving device for beverage containers is disclosed. The receiving device comprises a supporting construction that is open at the top, which can receive the particular beverage container and consists at least of a first material. Furthermore, at least one heat-conducting element which can forward heat and/or cold to a beverage container received by the supporting construction. In addition, one or more thermoelectric air-conditioning units for generating heat and/or cold. The one or more thermoelectrical air-conditioning units have a thermally conductive contact with the at least one heat-conducting element. The at least one heat-conducting element consists of at least one second material which has an elevated thermal conductivity in comparison to the at least one first material. |
| US10543762B2 |
Vehicle seat air-blowing apparatus and vehicle seat
A vehicle seat air-blowing apparatus including an air blower including an impeller configured to generate air flow and an air blower opening configured to allow the air flow to flow in a ventilation passage of a seat pad of a vehicle seat, and a cover provided to the air blower opening and including a cover ventilation opening configured to allow the air flow to flow therethrough and a protection part configured to suppress application of a load to the air blower opening, wherein the vehicle seat air-blowing apparatus is configured to be attachable to the vehicle seat along the seat pad at a position where an opening of the ventilation passage provided in a rear surface of the seat pad and the cover ventilation opening of the cover face each other. |
| US10543761B2 |
Air supply component for use with a seat
A seat includes an air discharge port configured to provide a thin stream of conditioned air along a body surface of a seat occupant. The air discharge port is part of an air supply component located in or along the seat bottom or backrest. The air discharge port is positioned to direct conditioned air along an external surface of the air supply component or of another surface of the seat to form an initial thin stream of conditioned air that follows external seat surfaces to reach and flow along the seat occupant. The air supply component can be made adjustable to allow the location and/or direction of the discharged air to be changed to accommodate and maintain the conditioned air in a thin stream. |
| US10543757B2 |
Techniques for adjusting wakeup time of an electrified vehicle for low voltage battery conditioning
A control system for an electrified vehicle having low and high voltage battery systems includes a set of vehicle modules that collectively draw an ignition-off draw (IOD) current from the low voltage battery system while the vehicle is off, a set of sensors configured to measure a set of parameters of at least one of the low and high voltage battery systems, and a controller configured to: estimate the IOD current, receive the set of measured parameters from the set of sensors, based on the set of measured parameters and the estimated IOD current, set a wakeup time indicative of a future time at which the low voltage battery system will require recharging, and based on the wakeup time, temporarily wakeup the vehicle such that recharging of the low voltage battery system using the high voltage battery system is enabled. |
| US10543753B2 |
Inductive power transfer pad and method of operating an inductive power transfer pad with scissor lift means for moving a primary coil
The invention relates to an inductive power transfer pad, in particular a transfer pad of a system for inductive power transfer to a vehicle, including a stationary part and a movable part, wherein the movable part includes a primary winding structure, wherein the inductive power transfer pad includes at least one actuating means, wherein the movable part is movable at least in a first direction by the at least one actuating means, wherein the inductive power transfer pad includes a scissor lift means, wherein the movable part and the stationary part are coupled by the scissor lift means, wherein a scissor arrangement of the scissor lift means is coupled to the stationary part by at least one fixed bearing, wherein the scissor arrangement is coupled to the movable part by at least one floating bearing, and a method of operating an inductive power transfer pad. |
| US10543748B2 |
Hybrid transmission for a motor vehicle
A transmission includes input and output shafts, a hybrid module coupled to the input shaft and a gearbox coupled to the module and output shaft. The hybrid module includes a first electric motor under driven by a gearset; a second electric motor coupled to a module output, a disconnect clutch coupled to the gearset and selectively to the input shaft; and a launch clutch coupled to the disconnect clutch and selectively to the module output. The gearbox includes three gearsets and five torque transmitting devices operable to generate six forward speeds. One torque transmitting device is a clutch brake applied with a piston that reaches over a park gear, and one is a selectable one way clutch. Two of the torque transmitting devices are radially stacked rotating clutches. The transmission includes and/or facilitates an engine only mode, an electric only mode, a hybrid mode and a battery charging mode. |
| US10543747B2 |
Method for operating a multi-axle powertrain for a motor vehicle, and corresponding multi-axle powertrain
A device and method for operating a multi-axle powertrain for a motor vehicle, with a first axle being permanently in operative connection and a second axle being at least temporarily in operative connection by a drive device via a clutch coupling. It is provided that, when the second axle is decoupled from the drive device and the starting clutch is disengaged, an expected wheel force is predictively ascertained. The determination of the wheel force takes into account a torque caused by a mass moment of inertia of the drive device, and the second axle is coupled with the drive device if the expected wheel force surpasses a maximum wheel force. |
| US10543746B2 |
Dual nozzle-receiving assembly
A nozzle-receiving assembly includes a housing including a fuel inlet that is configured to receive a first nozzle of a fuel dispenser in order to dispense fuel into a fuel fill pipe coupled to the fuel inlet. A door is moveably secured to the housing. The door is configured to be moved between an open position and a closed position. An additive inlet is secured to the door. The additive inlet is configured to receive a second nozzle of an additive dispenser to dispense additive into an additive conduit coupled to the additive inlet. |
| US10543745B2 |
Curve-combined square pressure tank
The present invention relates to a curve-combined square pressure tank with which curves are combined so as to maintain internal high pressure, improve space efficiency, and reduce the weight thereof, and to a pressure tank, in which planes and curves are combined, formed by connecting flat plate members and curved members, having a plurality of aligned tension members for connecting the flat plate members facing each other, and having stress buffer parts formed at connection parts of the flat plate members and the curved members so as to enable internal pressure to be maintained. |
| US10543744B2 |
Working vehicle
The working vehicle includes an engine installed in a front portion of a traveling machine body, and a post-processing device configured to purify exhaust gas from the engine. The post-processing device is mounted on an upper side of the engine. The engine and the post-processing device are covered with a hood. A hood shield plate is disposed on a rear surface side of the hood and covers at least the post-processing device from a rear surface. A heat insulating layer is formed between an operating seat disposed on a rear side of the hood and the hood shield plate. |
| US10543736B2 |
Vehicle cabin air management
A vehicle cabin pressure relief device is provided having a base layer defining an aperture, a retainer layer disposed on the base layer; and a sealing member. The sealing member further includes a first portion and a second portion extending from the first portion, wherein the second portion of the sealing member is sandwiched between the base layer and the retainer layer. The first portion is also displaceable relative to the base layer, and covers a portion of the aperture in a closed first position. |
| US10543734B2 |
Electrified vehicle cabin heating
An exemplary electrified vehicle assembly includes a battery pack, a cabin heater, and a coolant loop that communicates liquid coolant from the battery pack to the cabin heater. The cabin heater configured to heat a cabin of a vehicle with thermal energy from liquid coolant. |
| US10543731B2 |
Auxiliary HVAC system for a vehicle
A system for decreasing the response time of a vehicle heating ventilation and air conditioning (“HVAC”) system is described. A fan circulates air through a HVAC casing. Circulating air through the HVAC casing creates a high-pressure zone within the HVAC casing. A thermal expansion valve is located outside of the HVAC casing. An outlet port is located on the HVAC casing to allow air to be ported from the high-pressure zone toward the thermal expansion valve. Air ported from the high-pressure zone may be directed toward the thermal expansion valve by a nozzle. The air increases the temperature of the thermal expansion valve and allows additional refrigerant to flow through the thermal expansion valve. |
| US10543730B2 |
Auxiliary suspension air damping systems and associated methods of manufacture and use
Air damping systems for lift axles are described herein. In some embodiments, lift axle systems configured in accordance with the present technology can include one or more air springs for carrying vehicle sprung mass (“load springs”) and one or more air springs (or, for example, air cylinders) for raising the lift axle (“lift springs”). One or more air lines can be connected between the load springs and the lift springs so that, in operation, compression and extension of the load springs in response to axle movement causes pressurized air to flow back and forth between the load springs and the lift springs. As a result, the lift springs provide an additional volume to receive the pressurized air and provide an opposing spring force to the suspension. Additionally, in some embodiments the air line or lines extending between the load springs and the lift springs can include an air flow restriction and/or other air damping feature. In operation, the air damping feature dampens the flow of air between the load springs and the lift springs to provide damping of the vehicle suspension without the additional costs or disadvantages often associated with conventional hydraulic shock absorbers. |
| US10543725B2 |
System for determining towing equipment compatibility
Disclosed is a system for determining tow equipment compatibility that includes a processing device having a processor and non-volatile memory. The system also includes a data input device configured to input at least one unique tow equipment identification code (UTEIC) identifying a specific piece of tow equipment and properties thereof. The processor is configured to receive the UTEIC from the data input device, receive a user input, determine tow equipment compatibility based on the user input and the UTEIC, and communicate tow equipment compatibility data to a user. |
| US10543721B2 |
Tire pressure monitoring system and method of operating the tire pressure monitoring system
A method of operating a Tire Pressure Monitoring System (TPMS) includes executing tire pressure monitoring of at least one tire installed on a vehicle in a first mode, and transmitting frequency signal loss information to a center if a loss of a frequency signal in the first mode occurs in a designated time period. |
| US10543712B2 |
Methods for securing variable indicia on instant (scratch-off) tickets
A security-enhanced document, such as an instant lottery ticket, includes a substrate. Indicia is provided on the substrate, and a scratch-off-coating (SOC) layer is applied over the indicia to maintain the indicia unreadable until removal of the SOC layer. The indicia is printed onto the substrate as pigmented particles. One or more opacity film layers may be provided over or under the pigmented particle indicia. |
| US10543711B2 |
Authenticating identification and security documents and other objects
The application discloses apparatus and systems for authenticating physical object, identification documents and security documents. Some such methods and apparatus involve signal encoding or digital watermarking. |
| US10543709B1 |
Label book containing printed store labels for use along a retail shelf edge
Embodiments of a store label booklet include a plurality of sheets stacked one on top of the other and connected to a binding that spans an entire thickness of the booklet, each sheet including a planar array of store labels. No release coating is used. In some embodiments, the label may include a printed stock side, a liner including a removable portion, and an adhesive located between the liner and the printed stock side. In other embodiments the booklet may include a cardstock with a printed stock side and an adhesive on the side opposite the printed stock side. Each store label may differ in orientation, size, or style and may contain different product information. Location information may be located on a binding of the booklet, on the label, or on both the binding and the label. The store labels may be printed in a predetermined order. |
| US10543706B2 |
EIP protocol converter system for laser for dot peen marking systems
The EIP Protocol Converter System is a system that facilitates integration of laser or dot peer marking systems into factory automation networks using the standard EtherNet/lP (EIP) protocol. Built-in support for the EIP protocol greatly simplifies the PLC programming task, and lowers the cost of integrating the marking system into factory operations. |
| US10543705B2 |
Ink jet recording method using porous body
In an ink jet recording method including a step of absorbing a liquid component from an image formed of ink and a reaction liquid by a porous body of a liquid absorbing member, a resin fine particle agglomerated by the reaction liquid are contained in the ink, and a particle diameter d50 of a solid content contained in a mixture of the ink after agglomeration and the reaction liquid is larger than an average pore diameter of a porous membrane of the liquid absorbing member, and thereby adhesion of a coloring material to the porous body can be suppressed. |
| US10543703B2 |
Tape cassette and tape cassette unit
A tape cassette having a box-like case having first through sixth outer walls. The first and second outer walls extend in parallel and arranged in a first direction perpendicular to the first and second outer walls, the third and fourth outer walls extend in parallel and arranged in a second direction perpendicular to the third and fourth outer walls, the fifth and sixth outer walls extend in parallel and arranged in a third direction perpendicular to the fifth and sixth outer walls, and the first, second and third directions are perpendicular to each other. A discharging port is provided on the fourth outer wall, and a substrate having a storage storing electronically-retrievable information regarding the tape cassette. The substrate is provided to the third outer wall, and at least a part of the substrate overlaps at least a part of the discharge port in the second direction. |
| US10543702B2 |
Transportation device and recording apparatus
A transportation device includes a cover member that is displaceable between a closing position for closing an opening of a body case and an opening position for opening the opening, a processing unit that is arranged inside the body case, and performs a specified processing with respect to a medium transported to a working area communicating with the outside of the body case through the opening when the cover member is positioned at the opening position, and a transmitted unit that is positioned at a first position different from a position between the working area and the processing unit when the cover member is positioned at the closing position, and is positioned at a second position which is the position between the working area and the processing unit when the cover member is positioned at the opening position. |
| US10543694B2 |
Method and device for cleaning and protecting a hydraulic connection
The invention concerns a method for cleaning an ink circuit of an ink-jet printer, comprising at least one tank (10), referred to as the main tank, at least one ink cartridge (30), a pump (31) for pumping the ink from the cartridge, ducts and valves (32-35, 320, 340, 341, 343, 344) for fluid connection between the ink cartridge and the tank, and control panel (3) for controlling the printer, the method comprising at least: a step of sending solvent, at a pressure P1, to the cartridge (30), by at least a part of the ducts and valves for fluid connection between the ink cartridge (30) and the tank (10), a step of pumping at least a portion of the solvent, sent in step a), towards the main tank (10). |
| US10543692B2 |
Liquid supply unit
A liquid supply unit includes an outer shell, a liquid supply portion that is arranged in the outer shell and can supply a liquid to the liquid ejection apparatus, and an engaged structure including an engaged portion that can engage with the engagement portion of the liquid ejection apparatus, and a first opening that is formed in the outer shell and through which the engagement structure can be inserted. The engaged portion is arranged further inward than an outer surface of the outer shell. |
| US10543688B2 |
Recording apparatus with an electric field forming section
A recording apparatus includes an electric field forming section including a conductive member and configured to form an electric field, and the conductive member includes at least one first portion and a second portion, each of the at least one first portion being disposed at a position being nearer the recording head than a position of the second portion and included in a corresponding one of at least one liquid discarding region each of which, in an execution of borderless recording, is used for the ejection of the liquid onto an outside of a corresponding one of at least one edge whose position corresponds to each of at least one predetermined size of a medium, the second portion being disposed in a recording region other than the at least one liquid discarding region. |
| US10543686B2 |
Modular printing apparatus and method
A modular textile printing apparatus is made up of multiple modules which are combined together. Each module has one rail for bearing a printing functional unit such as a print head. A second rail perpendicular to the first rail faces the first rail, and carries a printing tray or platen holding items to be printed. The tray moves along the rail. A third rail parallel to said second rail and facing away from the printing functional unit, is also for carrying the tray. The modules are connected together and the apparatus provides a starting point for loading and unloading the trays. The second rails are aligned with each other to form a continuous printing feed along the modules and the third rails are aligned to provide a return path after printing to the starting point for reloading. |
| US10543681B2 |
Liquid jet head and liquid jet device
An object of the invention is to provide a liquid jet head and a liquid jet device each capable of improving the print quality even in the case in which an error occurs in the print data. The liquid jet head includes a receiving section adapted to receive print data, a discriminant section adapted to discriminate whether or not the print data received is non-defective, and a control section adapted to hold the print data in a case in which the print data is non-defective, or perform printing based on the print data held currently without holding the print data received in a case in which the print data received is defective. |
| US10543679B2 |
Ink jet printing apparatus
A liquid holding amount of a porous body of a liquid absorbing member for removing at least a portion of an aqueous liquid component from an image obtained by ink jet printing is controlled so as to reduce damage to the porous body while maintaining performance of removing attached matters from the porous body by using a cleaning member which abuts on the porous body and has an adhesive force. |
| US10543677B2 |
Transfer member for transfer-type inkjet recording, inkjet recording method and inkjet recording apparatus
The transfer member for transfer-type inkjet recording of the present invention is formed so that a surface layer includes an organosiloxane compound having a polyalkylene oxide unit and the contact angle of water and the contact angle of hexadecane on the surface are 85° or more and 110° or less and 25° or more and 50° or less, respectively. |
| US10543667B2 |
Easy opening metalized hermetic films and methods to manufacture the same
Composite film structures for packaging use. The composite film structures have easy open, clean peel and hermetic seal characteristics stemming from good caulkability characteristics when a region of the composite film structures are folded over and sealed to form a seal on a bag, pouch or package. The composite film structure includes a base film which includes a biaxially-oriented film and a vacuum-deposited metal layer and a heat-sealant structure comprising a low density polyethylene and a linear low density polyethylene. The metal layer is between the biaxially-oriented film and the heat-sealant structure. The heat-sealant structure thickness is from about 50 to about 100 gauge, the adhesion strength between the biaxially-oriented film and the metal layer is less than about 800 g/in, and the seal strength when a region of the composite film structure is folded onto a composite film structure region is from about 500 to about 1500 g/in. |
| US10543658B2 |
Ribbed film structures with pigment created visual characteristics
In one example embodiment, a film includes a coextruded structure having both an extruded ribbed skin layer that includes a plurality of ribs, and a core layer. The ribs are spaced apart by a web that is integral with the ribs. The film also includes a coloring agent that is substantially more apparent in the ribs than in the web, such that a contrast in color and/or color intensity between the ribs and the web is visible. |
| US10543655B2 |
Binding member, binding device, and image processing apparatus
There is provided a binding member. An upper toothed part having projections and recesses for forming irregularities in a bundle of recording materials. A lower toothed part having projections and recesses for forming irregularities in the bundle of recording materials and forming a pair with the upper toothed part. In at least one of the upper toothed part and the lower toothed part, in a cross section shape of the toothed part, the recesses of the toothed part have depressed areas depressed from virtual lines which are extensions of inclined surfaces of the toothed part. |
| US10543652B2 |
Press
Embodiments related to press machines, including presses to extract juice from food matter contained within a cartridge. The cartridge is compressible by the press and juice can be expelled through a cartridge outlet extendible though the press region. |
| US10543641B2 |
3D printer having dual stage structure
A 3D printer has a dual stage structure and includes: a frame; an extrusion unit having a nozzle configured to extrude a raw material; a stacking base unit positioned under the extrusion unit and configured to receive the raw material on a surface thereof so that an object is formed in a layer-by-layer manner on the surface; and a cutting unit positioned between the stacking base unit and the extrusion unit and configured to grind or cut the object formed on the surface of the stacking base unit, wherein the frame is configured to be connected to outer sides of the stacking base unit, the extrusion unit, and the cutting unit, the stacking base unit and the cutting unit are configured to be vertically movable along the frame, and the nozzle is configured to be movable on a plane. |
| US10543636B2 |
Blow-molding machine and method of sterilizing the same
To simply sterilize a blow-molding machine. A mist or gas of hydrogen peroxide or a mixture thereof is introduced through a valve block disposed adjacent to a molding die, thereby sterilizing at least the molding die and an extension rod that extends into the molding die through the valve block. |
| US10543633B2 |
Injection molding device comprising movable strippers
A molding device for manufacturing a plastic hollow part by injection molding includes an injection nozzle and first and second molding stations. Each molding station has a first mold including two mold halves forming, respectively, first and second mold cavities, and a core having a first end, which can be at least partially located inside the first and second mold cavities. A first stripper can be arranged on the core in a passive position, spaced from the first end of the core at a first distance; in a molding position, spaced from the first end of the core at a second distance; and in a demolding position, spaced from the first end of the core at a third distance; wherein the first distance is greater than the second distance, and the second distance is greater than the third distance. |
| US10543631B2 |
Method of forming a headset assembly
A method of forming a headrest assembly includes providing a first mold that encloses a first cavity in a closed condition. A support is positioned in the first cavity. A first material is blow molded into the first cavity and around a portion of the support to form a core part. The core part and support are removed from the first mold. A second mold encloses a second cavity in a closed condition. The core part and the support are placed into the second mold in an open condition. A fluid is injected into the core part through the support. The second mold is converted to the closed condition. A second material is injection molded into the second cavity and around the core part to form an outer shell around the core part. A fluid is withdrawn from the core part through the support. |
| US10543630B2 |
Reel based closure system employing a friction based tension mechanism
A reel based tensioning device includes a housing, a spool that is rotatably positioned within the housing, and a knob member that is operably coupled with the spool to cause the spool to rotate in a first direction within the housing and thereby wind a tension member about the spool. The reel based tensioning device also includes a load holding mechanism that is coupled with the spool and that is configured to rotate the spool in the first direction within the housing and to prevent rotation of the spool in a second direction to prevent unwinding of the tension member from about the spool. The reel based tensioning device further includes an audible component that is configured to produce an audible noise responsive to operation of the knob member to signal an adjustment of the tension member. |
| US10543627B2 |
Method for manufacturing foamable injection molding and injection device therefor
An injection apparatus including a plasticizing unit (2) that plasticizes a raw material resin and an injection unit (3) that injects a plasticized molten resin. The plasticizing unit includes a heating cylinder (20) having a foaming gas injection valve and a screw (21) provided inside the heating cylinder. The rotation and advance and retreat movements of the screw are controlled such that a raw material resin is plasticized by the screw and a foaming gas injected from a foaming gas injection valve is dissolved in the plasticized molten resin. After the screw retreats to a prescribed position according as the molten resin accumulates in the front end side of the heating cylinder by the screw that is rotating, the screw advances with rotating to cause the molten resin which has been accumulated in the front end side of the heating cylinder to be transferred to the injection unit. |
| US10543626B2 |
Poly(vinyl chloride) substrates and method for producing the same
Articles and methods of manufacture of poly(vinyl chloride)-based substrates are described. The substrates may be utilized in various consumer, industrial, transportation, building and construction, and agricultural applications and may include reclaimed poly(vinyl chloride). |
| US10543623B2 |
Injector for filling a mold with plastic particles
The invention relates to an injector for filling a mold with plastic particles, with a front part (2) and a base part (3), wherein the front part (2) has a mold-side orifice (23) and a feed for compressed air (15) and a feed for plastic particles (11), and the base part (3) is attached axially in the direction of conveyance behind the front part (2) and has a piston-cylinder unit (30, 37, 38), wherein a closing piston (49) for closing the mold-side orifice (23) is axially movable through the front part (2), together with an apparatus and a method for the production of a particle form part. The injector is characterised in that the closing piston (49) and the piston rod (47) bearing the closing piston on its front side have equal diameters or substantially equal diameters and the method comprises the following steps: feeding form particles from a material container to a mold by means of a pipe thermoplastic welding of the form particles in the mold into a particle form part under a supply of heat, wherein steam is added to the form particles to be fed. |
| US10543618B2 |
Pallet feed method and apparatus for use on a concrete products machine
A pallet feeder assembly for use with a concrete products machine of a type supporting a mold box within a production zone comprises a conveyor having a load/unload expanse configured to be disposed below the production zone, an upstream staging expanse upstream, and upstream and downstream ends. A plurality of sensors operative to detect a presence of a pallet on the conveyor are disposed along a length of the conveyor and include sensors disposed upstream and downstream of the load/unload expanse. Transport means on the conveyor move a pallet loaded on the transport means between the upstream and downstream ends of the conveyor. An open portion within the load/unload expanse is configured to admit a lifting means for raising the pallet from the transport means up into the production zone against an underside of a mold box during a production cycle of a concrete products machine. |
| US10543617B2 |
System and method of connecting two 3D printed structures
A method for forming three-dimensional (3D) printed structures is disclosed. The method may include 3D printing a first structural member including an opening to a cavity inside the first structural member; and 3D printing a second structural member including a protrusion disposed within the opening and the cavity of the first structural member. |
| US10543614B2 |
Structural butt finger joint for flat boards
A structural joint for attaching two boards by their butts, achieving the correct transmission of forces between them by means of a staggered configuration of the butts thereof to increase the contact surface between both boards, allowing the mutual coupling thereof, both being aligned and coplanar, and at least one of the steps of both boards having a finger profile to further increase the contact surface between both boards. |
| US10543613B2 |
Cutting machine for food
A cutting machine for cutting slices of in particular strand-shaped cutting material includes: a machine housing; a drive motor; a cutting blade, driven in rotation by the drive motor in a cutting plane, for cutting off slices; a stop plate, displaceable parallel to the cutting plane, for setting a desired slice thickness; a carriage, movable back and forth parallel to the cutting plane, having a supporting plate and a bearing wall, the supporting plate and the bearing wall forming a holding device for the cutting material, the carriage including a pivoting device for moving the supporting plate between a starting position and a pivoted-up position, the supporting plate in the starting position and in the pivoted-up position forming a right angle with the cutting plane; and a fixing plate arranged orthogonal to the supporting plate and being rigidly connected to the supporting plate, the fixing plate including a slotted link. |
| US10543607B2 |
Handheld personal care device
A handheld personal care device according to the present disclosure includes: an operation switch configured to change a treatment operation of an operation unit; a sensor electrode configured to cause a change in capacitance depending on whether or not the grip unit is grasped; and a control device electrically connected to the operation switch and the sensor electrode and configured to control the treatment operation of the operation unit. The control device includes: a grasp detector configured to detect that the grip unit is grasped based on a change in capacitance of the sensor electrode; and a change permission part configured to permit the operation switch to change the treatment operation of the operation unit when the change permission part receives, from the grasp detector, grasp information indicating that the grip unit is grasped. |
| US10543600B2 |
Pick-and-place head and method for picking work-pieces
A pick-and-place head for picking a plurality of work-pieces from at least one first location and for placing the plurality of work-pieces at least one second location is disclosed. The pick-and-place head exhibits a plurality of nozzles, wherein each nozzle is configured to engage one of the work-pieces by action of a vacuum. At least one nozzle has an individual vacuum supply and at least two further nozzles have a shared vacuum supply. A corresponding method is also disclosed, the method including the steps of approaching at least one of the plurality of work-pieces with a respective nozzle and then starting generation of a vacuum at each respective nozzle. The generation of vacuum in at least one nozzle is achieved by an individual vacuum supply, and generation of vacuum in at least two further nozzles is achieved by a shared vacuum supply of the at least two further nozzles. |
| US10543587B2 |
Socket wrench
The present invention provides a socket wrench, including a main body and a control sleeve. The main body includes a socket end and a connection end. The socket end is configured to be connected with a fastener. The connection end is configured to be connected with the insertion portion. The connection end includes at least one first through hole. At least one positioning member is movably restricted within the at least one first through hole. The control sleeve is movably assembled to the connection end. The control sleeve includes a first portion and a second portion. The first portion has at least one receiving hole which is selectively correspondable to the at least one first through hole. The first portion is inserted into the second portion. The at least one receiving hole is disposed inside the second portion. |
| US10543586B2 |
Ratchet wrench and method for making the same
A ratchet wrench includes a body, a ratchet wheel, a pawl, a ring, a top clip and a bottom clip. The body includes a through hole which defines through the top and the bottom of the body. A top recessed area and a bottom recessed area are respectively defined in the top and the bottom of the body. A recess is defined in the inner periphery of the through hole and a protrusion with a receiving slot extends from one end of the recess. A resilient member is received in the receiving slot to bias the pawl in the recess to engage with the ratchet wheel. The ring is engaged with the top recessed area. The top clip is engaged with the top recessed area and clips the ratchet wheel. The bottom clip is engaged with the bottom recessed area and clips the ratchet wheel. |
| US10543578B2 |
Blocking calculation module
The invention proposes a blocking calculation module (1) configured to calculate blocking data of an ophthalmic lens member (2) on a blocking element (3) of a blocking station (4), comprising:—receiving means (11) configured to receive input data from a remote device, the input data comprising optical data related to the ophthalmic lens member,—calculation means (15) configured to calculate the blocking data from the input data, and—transmitting means (17) configured to make the blocking data available to the blocking station. |
| US10543572B2 |
Mobile welding system
A mobile welding system that does not rely exclusively on a track to define the path of the welder. The present invention generally provides a mobile welder adapted to move along a work piece, the mobile welder including a chassis supporting a motor assembly; a travel assembly attached to the chassis and adapted to support the chassis over a portion of the work piece, wherein the motor is coupled to the travel assembly to selectively cause the chassis to move relative to the work piece; a controller connected to the motor assembly to control movement of the chassis relative to the work piece; a chassis holder connected to the chassis, the chassis holder being adapted to provide a force holding the chassis a selected distance from the work piece; and a welder supported on the chassis, the welder including an implement adapted to perform a welding operation, wherein the implement is supported on the chassis at a location where the implement and the chassis define an uninterrupted line of sight from the implement to the work piece, wherein the chassis holder is spaced from the line of sight a distance sufficient to prevent the chassis holder from interfering with the welding operation. |
| US10543571B2 |
Cu-added Ni—Cr—Fe-based alloy brazing material
A Ni—Cr—Fe-based alloy brazing filler material to which Cu is added, and which has a low melting temperature, and is inexpensive and excellent in corrosion resistance and in strength, for use in manufacture of stainless-steel heat exchangers or the like, specifically, a Ni—Cr—Fe-based alloy brazing filler material, including, in mass %, Cr: 15 to 30%; Fe: 15 to 30%; Cu: 2.1 to 7.5%; P: 3 to 12%; and Si: 0 to 8%; and the balance being Ni and unavoidable impurities, wherein the total content of Cr and Fe is 30 to 54%, and the total content of P and Si is 7 to 14%. |
| US10543567B2 |
Method for producing a strip of rubber including non-continuous reinforcements and device for implementing same
A method of manufacturing a strip of rubber having discontinuous reinforcer segments includes a conveying step in which a rubber strip is conveyed in a direction DC, and a cutting step in which reinforcers of the strip are cut. The cutting step includes localized heating of each reinforcer using a laser beam from a remote source. A cutting device useable to perform the cutting step includes a conveying device and a cutting head. The conveying device moves the strip in the conveying direction DC past the cutting head. The cutting head includes an emitter from which at least one laser beam is produced to cause localized heating of at least one reinforcer of the strip, in order to cut the at least one reinforcer into discontinuous reinforcer segments. The strip may be conveyed continuously or discontinuously, such that the strip may be moving or immobilized during the cutting step. |
| US10543566B2 |
Method for producing an ophthalmic lens comprising a step of laser marking in order to produce permanent etchings on one surface of said ophthalmic lens
A method for producing an ophthalmic lens includes a step of laser marking in order to produce permanent etchings on one surface of the lens, at least one predefined step subsequent to the marking step and implementing extreme thermal stress that is applied to the surface, and a step of determining an operating point (PF) of a laser marking machine (1) configured to implement the marking step from geometric characteristics (Di) of the etchings to be made, the determining step including the steps of determining (304) a value (CPM) representative of the deformation of the lens on at least one treatment area of the surface, from the stress and data relative to a predetermined material from which the lens is formed, and of deducing (308) the operating point from the value representative of deformation and from the geometric characteristics. |
| US10543565B2 |
Laser welding method for producing a semi-finished sheet metal product made of hardenable steel and comprising a coating based on aluminium or aluminium-silicon
A method for producing a tailor-made semi-finished sheet metal product where two steel sheets of different material grades and/or thicknesses are joined by laser welding. At least one of the sheets is press-hardenable steel having a metallic coating of aluminium or aluminium-silicon. Filler wire is fed into the weld melt. The filler wire is substantially free of aluminium and contains at least one alloy element which promotes the formation of austenite in a content that is at least 0.1 wt. % greater than that in the press-hardenable steel. The filler wire is heated before being fed into the weld melt. The steel sheets have a gap delimited by the edges of the sheets having an average width of at least 0.15 mm. The ratio of the volume of filler wire inserted into the gap to the volume of the steel sheet material melted by the laser beam is at least 20%. |
| US10543564B2 |
Wafer alignment with restricted visual access
Wafer alignment with restricted visual access has been disclosed. In an example, a method of processing a substrate for fabricating a solar cell involves supporting the substrate over a stage. The method involves forming a substantially opaque layer over the substrate. The substantially opaque layer at least partially covers edges of the substrate. The method involves performing fit-up of the substantially opaque layer to the substrate. The method involves illuminating the covered edges of the substrate with light transmitted through the stage, and capturing a first image of the covered edges of the substrate based on the light transmitted through the stage. The method further includes determining a first position of the substrate relative to the stage based on the first image of the covered edges. The substrate may be further processed based on the determined first position of the substrate under the substantially opaque layer. |
| US10543563B2 |
Conductive wire welding method, stator, and high-frequency induction heating device
A conductive wire welded structure of which a stator is composed can be obtained using a conductive wire welding method in which a plurality of conductive wires are welded together using a high-frequency induction heating device. This conductive wire welding method involves performing a disposition step in which a plurality of conductive wires are made to intersect and the end of at least one of the conductive wires is disposed at a location that is extended from an intersection portion, and a welding step in which the end of the at least one conductive wire that is at a location extended from the intersection portion is welded outside an induction heating coil by induction heating, and the welded material thereof is solidified at the intersection portion. |
| US10543561B2 |
Welding gun
A welding gun includes a driving-force transmission mechanism which converts linear displacement of an output unit of a driving unit into rotational displacement of a clamping arm. The driving-force transmission mechanism includes: an inclined part which is integrally displaced with the linear displacement of the output unit, and which is inclined with respect to the displacement direction of the output unit; and a part to be pressed which is pressed by the inclined part. The clamping arm rotates in accordance with movement of the part to be pressed which is pressed by the displaced inclined part, and generates clamping force. |
| US10543556B2 |
Systems and methods for welding zinc-coated workpieces
A welding system includes a welding power source configured to provide pulsed electropositive direct current (DCEP), a gas supply system configured to provide a shielding gas flow that is at least 90% argon (Ar), a welding wire feeder configured to provide tubular welding wire. The DCEP, the tubular welding wire, and the shielding gas flow are combined to form a weld deposit on a zinc-coated workpiece, wherein less than approximately 10 wt % of the tubular welding wire is converted to spatter while forming the weld deposit on the zinc-coated workpiece. |
| US10543554B2 |
Welding assembly for high-bandwidth data communication
A welding or cutting system is provided that uses welding cables between a wire feeder and a power supply for high-speed data communications between the wire feeder and the power supply. A system designed as discussed herein eliminates the need for voltage and/or current sense leads for communication arc voltages/currents detected at the welding operation. |
| US10543553B2 |
High current AC welder
A welding assembly and method is described which includes a charging circuit and regulator coupled to an input power source; an energy storage element connected in parallel with the charging circuit and regulator to increase the weld current output, wherein the energy storage element is charged by the charging circuit and regulator; and a weld output controller connected in parallel with the energy storage element for controlling a welding arc between an electrode and a workpiece, wherein the weld output controller includes a forward converter/inverter including a series circuit of a primary winding of a transformer, and a switching element which is coupled to the energy storage element, and a rectifier smoothing circuit which rectifies and smoothes a voltage induced in a secondary winding of the transformer according to a switching operation of the switching element, wherein the rectifier smoothing circuit conducts during an ON period of the switching element. |
| US10543552B2 |
Welding power source with conformal antenna
A welding system including a plurality of welding components (20, 21, 33, 43) communicating via a wireless system using low profile and planar antennas (40) is disclosed. The welding system comprises a welding power source (43) and one or more other welding system component(s) (20, 21, 33) communicating via Zigbee or other wireless communication networks. Communications are transmitted between the components (20, 21, 33, 43) of the welding system through antennas (40) mounted externally to the housing of the welding equipment(s) (20, 21, 33, 43). The antennas (40) can be low-profile planar antennas (40), either linearly or circularly polarized, which can be advantageously mounted to a housing while limiting undesirable contact with the environment and therefore to limiting the potential for damage. |
| US10543551B2 |
Synchronized rotating arc welding method and system
A welding method includes feeding a welding electrode axially from a welding torch, moving the welding electrode radially in a desired pattern with respect to a central axis of the welding torch by a motion control assembly within the welding torch, transmitting from control circuitry a signal corresponding to a position of the welding electrode relative to a weld joint or weld pool, advancing the welding torch or a workpiece to establish a weld, and transferring material from the welding electrode to a first location in an area of the weld pool. The welding electrode moves radially while feeding the welding electrode from the welding torch, the material from the welding electrode is transferred to the first location during a first cycle of the desired pattern, and the first location is controlled based at least in part on the signal. |
| US10543546B2 |
Wire electric discharge machine including average discharge delay time calculating unit
In a wire electric discharge machine, time from application of a voltage to a machining gap between a workpiece and a wire electrode until occurrence of electric discharge is measured as a discharge delay time, and the measured discharge delay time is integrated over a predetermined measurement period to calculate a discharge delay integrated time. Further, the number of times of the voltage application in the measurement period is counted. An average discharge delay time per voltage application in the measurement period is calculated from the discharge delay integrated time and the number of times of voltage application. The movement of the wire electrode with respect to the workpiece is controlled on the basis of the average discharge delay time. |
| US10543544B2 |
Tool for fine machining of bores
This disclosure relates to a machine tool comprising a tool holder which rotates relative to a workpiece to be machined and has a tool axis, and a plurality of cutting inserts that are removably attached to the tool holder, the active cutting edges of said cutting inserts having a common cutting circle which is coaxial to the tool axis. According to this disclosure, the tool holder has a cylinder-type insert seat shell for radially positioning the cutting inserts, which rotates about the tool axis. The cutting inserts have at least one contact surface that can be brought into contact with the insert seat shell. |
| US10543539B2 |
Drilling aid apparatus and a method for drilling a structure
Drilling aid apparatuses and methods for drilling a structure are provided. In one example, a drilling aid apparatus includes a bushing holder portion. The bushing holder portion has a first surface for facing a first structure portion, a second surface on a side opposite the first surface, and an opening formed through the bushing holder portion extending from the first surface to the second surface. The opening is configured to receive a bushing that is sized for guiding a drill bit for drilling into the first structure portion. A first coupling member is coupled to the bushing holder portion and is configured to couple to a second structure portion for supporting the bushing holder portion in a fixed position relative to the first structure portion. |
| US10543537B2 |
Method for manufacturing machine component, apparatus for manufacturing machine component, method for machining rotation symmetry plane, recording medium, and program
A method for manufacturing a machine component having a rotation symmetry plane includes machining a rotation symmetry plane. The machining a rotation symmetry plane includes determining a track of the cutting. The determining a track determines the track in accordance with a condition that (1) a first end portion of the cutting edge is positioned at a cutting start position of the rotation symmetry plane, (2) N regions defined by division of the cutting edge successively come in contact with the rotation symmetry plane, (3) an inclination of a tangent line at a point of cutting of each of the N regions is equal to a target inclination of a tangent line which passes through the point of cutting and comes in contact with the rotation symmetry plane in a cut plane of the rotation symmetry plane, and (4) a second end of the cutting edge is positioned at a cutting end position of the rotation symmetry plane. |
| US10543534B2 |
Apparatus and method for the production of quantum particles
Systems, methods, and devices are disclosed for producing quantum particles (e.g., quantum dots) having a uniform size by vaporization of molten precursor droplets. More particularly, the present technology produces quantum dots by melting or liquefying solid and substantially pure precursor materials followed by production of uniformly sized droplets of molten precursor by use of a droplet maker into a microwave generated plasma torch. |
| US10543523B2 |
Forging tool for the manufacturing of a shaped rolled ring, notably for the manufacture of a turbomachine disc
Mandrels for rolling a ring include recesses for receiving the ring, which have rounded parts at the connection between the various faces, so as to avoid the formation of sharp angles on the rolled ring and the accidental formation of cracks. |
| US10543522B2 |
Processing unit and machine tool for the punching processing of workpieces
A processing unit of a machine tool for the punching processing of workpieces, in particular metal sheets, has a punching tool carrier configured to receive a punching tool and a stripper carrier for a stripper. The punching tool carrier can be moved by a punch drive along a stroke axis by a transverse drive element being driven by a punch drive motor relative to the punching tool carrier with a transverse drive movement along a transverse movement axis which extends in the transverse direction of the stroke axis. The stripper carrier can be moved along the stroke axis by a stripper drive, and the transverse drive element of the punch drive during the transverse drive movement can be moved relative to the stripper carrier along the transverse movement axis and the punching tool carrier and the stripper carrier can be moved relative to each other along the stroke axis. |
| US10543519B2 |
Manufacturing method for bent member and hot-bending apparatus for steel material
A manufacturing method for a bent member of the present invention includes a holding step of holding one end portion of a long steel material having an opening end in a longitudinal direction by a chuck, a feeding step of feeding the steel material in the longitudinal direction with the one end portion as a head after the holding step, a heating step of performing high-frequency induction heating on a portion of the steel material in the longitudinal direction to form a heated portion, a bending step of moving the chuck in a three-dimensional direction to apply a bending moment to the heated portion, and a cooling step of injecting a cooling medium to the heated portion to cool the heated portion after the bending step. When the heating step is started, the chuck is cooled by the cooling medium in a state where a heating amount applied to the one end portion when the heated portion is formed on the one end portion is greater than that of an upstream side adjacent portion adjacent to the upstream side of the one end portion as seen along a feeding direction of the steel material. |
| US10543515B2 |
Cleaning of nanostructures
The present invention relates to a method for removing a polymeric material from a surface of a nanostructure. The method includes applying, by a scanning probe microscope, an electrical field between a probe tip of the scanning probe microscope and the nanostructure, and simultaneously scanning over the surface of the nanostructure. Thereby, bonds connecting the polymeric material to the surface of the nanostructure are broken. A further step includes cleaning the surface of the nanostructure. A scanning probe microscope for performing such a method and a computer program product for controlling the scanning probe microscope are also disclosed. |
| US10543512B2 |
Apparatus and method of separation with a pressure differential device
A device and system applicable to separating components of a slurry is disclosed. The slurry can be a mixture of drilling fluid and drilling cuttings that can be separated with a separatory screen. A separatory tray can be disposed below an underside of the separatory screen. A pressure differential pan can provide fluid flow to a sump. A pressure differential generator can be located within the pressure differential pan and create a pressure differential between an upper side and a lower side of the separatory screen to enhance the flow of drilling fluid through the separatory screen. |
| US10543511B2 |
Material coating system and method
A material coating system for an apparatus having a housing configured to contain a fluid is disclosed herein. A multi-layer coating is applied to the housing to mitigate damage caused by external factors. The multi-layer coating includes: a layer of a primer coating having anti-corrosive properties, a layer of a mid coating having mechanical and chemical properties capable of at least partially closing a hole in the housing to avoid fluid leakage and optionally a layer of a top coating having properties that resist ultraviolet radiation from passing therethrough. |
| US10543505B2 |
Nozzle for grease application and methods for using
A tip end face of a body part 13 is provided at a part in front of a discharge port with respect to a rotational direction of a worm wheel 2 with a protruding part 16, and a tip end face of the protruding part 16 is provided with a grease-pushing surface part 17 configured to push grease into concave portions of a worm wheel teeth 3 while raking and leveling the grease so that the grease is substantially uniform in a width direction and in a circumferential direction of the worm wheel teeth 3. Also, the tip end face of the body part 13 is provided at a rear part of the discharge port with respect to the rotational direction of the worm wheel 2 with a protruding wall part 18 for preventing the grease 1 from moving rearwards with respect to the rotational direction of the worm wheel 2. |
| US10543502B2 |
Work piece processing arrangements
A workpiece processing arrangement comprises a spray booth (2) defining a work space (21), and operable to provide a controlled environment for spraying of material, a first oven (4) located adjacent a first end of the spray booth, the first oven defining an internal zone, and a second oven (5) located adjacent a second end of the spray booth, the second oven defining an internal zone (51). The arrangement also includes a transport rail (6) which extends from the internal zone (41) of the first oven (4), through the work space (21) of the spray booth (2) into the internal zone (51) of the second oven (5), the transport rail (6) being adapted for transport of a workpiece (10) between the work space (21) of the spray booth (2) to the internal zone of the first or second oven (4, 5). A corresponding method of processing a work piece in such an arrangement indicates the steps to be used when processing a first and a second workpiece The ovens may have both a baking and a curing zone. A ventilation system with an air curtain (23) may be included. |
| US10543500B2 |
Pump with a polymer spring
A fluid pump includes a plastomer spring. The spring includes a first end portion and a second end portion and a plurality of rhombus shaped spring sections, joined together in series at adjacent corners and aligned with each other in an axial direction to connect the first end portion to the second end portion. The spring sections can be compressed in the axial direction from an initial condition to a compressed condition and can subsequently expand to their initial condition. |
| US10543498B2 |
Sealant coating nozzle and sealant coating apparatus
A sealant coating nozzle and a sealant coating apparatus are provided. The sealant coating nozzle includes a nozzle cavity, a nozzle opening communicated with the nozzle cavity, telescopic inner films located in the nozzle cavity and driving apparatuses configured to drive the telescopic inner films to deform in the nozzle cavity; a volume of the nozzle cavity is reduced by the telescopic inner films in a first deformation state to extrude sealant in the nozzle cavity via the nozzle opening, and the volume of the nozzle cavity is increased by the telescopic inner films in a second deformation state to suck the sealant at the nozzle opening into the nozzle cavity. |
| US10543497B2 |
Base body of pressurized spray, and pressurized spray provided with such base body
To provide a base body of pressurized spray that makes it possible to stabilize a pressing spring and also to reduce the number of assembling processes. The base body 2, which is assembled into a pressurized spray A that is attached to a container so as to suck a liquid inside the container into a cylinder part 6 through an F valve 7 from an introduction pipe 4, and by applying a pressure to the liquid inside the cylinder, the liquid is jetted out through an S valve 10 from a nozzle, is provided with: an attaching part for use in attaching the introduction pipe 4 on a lower side, which is attached between a cap and a container mouth part, and a pressing spring part 11 that is attached onto an upper side and presses the S valve 10 in a valve closing direction. |
| US10543494B2 |
Electrostatic coating device and system
PROBLEM TO BE SOLVED: To evolve a spark discharge preventing effect of an electrostatic coating device.SOLUTION: One coating robot has an arm equipped with a plurality of electrostatic coating devices 100 close to each other and the plurality of the electrostatic coating devices 100 is connected in parallel with each other to one high-voltage generator 102. A hollow rotary shaft 108 driven by an air motor 104 is disposed with nine plate-shaped resistors 120 arranged circumferentially at intervals. The nine plate-shaped resistors 120 are connected in series and a high voltage is applied via the resistors 120 to a rotary atomization head 110. The rotary atomization head 110 is made of a semiconductive resin. |
| US10543492B2 |
Method and apparatus for intelligent magnetic separator operation
A system includes a first magnetic separator, which includes a first housing or is installed in a user's first housing process system, defining a product flow path through which a material may pass, one or more magnets that generate a magnetic field that is positioned within the product flow path to attract metal from the material as the material passes through the product flow path, and a first sensor to detect a presence of captured metal contaminants on the one or more magnets, such as via a measurement of a strength of the magnetic field. The system includes a first controller configured to receive a signal from the first sensor, the signal indicating the presence of the captured metal contaminants on the one or more magnets, and send an instruction related to the signal. |
| US10543490B2 |
Arrangement and method for detaching an adhering charge from an inner wall of a grinding tube
An arrangement and method for detaching an adhering charge from an inner wall of a grinding tube, wherein the grinding tube is rotated backwards in a drive-free manner from a pre-determinable, assumed rotary position by the weight force of the adhering charge, where at least one movement state variable of the grinding tube is detected and the grinding tube is braked while being rotated back in dependence on the at least one detected movement state variable in order to detach the adhering charge from the inner wall of the grinding tube, and where the arrangement includes a detecting device, a drive unit, a braking device and a control device. |
| US10543486B2 |
Microperturbation assembly system and method
Microperturbation fluidic assembly systems and methods are provided for the fabrication of emissive panels. The method provides an emissive substrate with a top surface patterned to form an array of wells. A liquid suspension is formed over the emissive substrate top surface, comprising a first liquid and emissive elements. Using an array of micropores, a perturbation medium, which optionally includes emissive elements, is injected into the liquid suspension. The perturbation medium may be the first liquid, a second liquid, or a gas. A laminar flow is created in the liquid suspension along the top surface of the emissive substrate in response to the perturbation medium, and emissive elements are captured in the wells. The ejection of the perturbation medium can also be used to control the thickness of the liquid suspension overlying the top surface of the emissive substrate. |
| US10543482B2 |
Catalyst solution for electroless plating
The present invention relates to a stable palladium ion catalyst aqueous solution for electroless metal plating that does not use boric acid and can be used stably over a wide pH range. The catalyst solution for electroless plating of the present invention contains palladium ion, palladium ion complexing agent, and a specific amine compound and is alkaline. |
| US10543479B2 |
Hydrocarbon conversion catalyst composition
A hydrocarbon conversion catalyst composition which comprises ZSM-48 and/or EU-2 zeolite particles and refractory oxide binder essentially free of alumina in which the average aluminium concentration of the ZSM-48 and/or EU-2 zeolite particles is at least 1.3 times the aluminium concentration at the surface of the particles, processes for preparing such catalyst compositions and processes for converting hydrocarbon feedstock with the help of such compositions. |
| US10543477B2 |
Polymer capsule having loaded thereon transition metal particles having excellent water dispersibility and stability, and method for preparing same
Provided are a polymer capsule loaded with transition metal particles having excellent water dispersibility and stability, and a method for preparing the same. Specifically, the polymer capsule loaded with transition metal particles according to the present invention includes a surface-modified polymer capsule surface-modified to thereby have a positive zeta potential in a dispersed state in water; and transition metal particles loaded on a surface of the surface-modified polymer capsule. In addition, a method for preparing a polymer capsule loaded with transition metal particles according to the present invention includes a) preparing a polymer capsule; b) surface-modifying the polymer capsule to prepare a polymer capsule having a positive zeta potential in a dispersed state in water; and c) sequentially adding a water-soluble transition metal precursor and a reducing agent to a water dispersion of the surface-modified polymer capsule obtained in step b). |
| US10543476B2 |
Porous materials, methods of manufacture thereof and articles comprising the same
Disclosed herein is a porous material comprising a biopolymer functionalized with a carbon dioxide capturing moiety; where the biopolymer is in the form of a foam or an aerogel having a bulk density of 500 grams per cubic meter to 2500 grams per cubic meter. Disclosed herein too is a method comprising functionalizing a biopolymer with a carbon dioxide capturing moiety; dissolving the biopolymer in an aqueous solution to form a first solution; reducing the temperature of the first solution to below the freezing point of the aqueous solution; displacing the aqueous solution with a first solvent that has a lower surface tension than a surface tension of the aqueous solution; and drying the first solvent to produce a porous biopolymer having a bulk density of 500 grams per cubic meter to 2500 grams per cubic meter. |
| US10543468B2 |
Supercritical reactor systems and processes for petroleum upgrading
Provided herein are supercritical upgrading reactors and reactor systems for upgrading a petroleum-based composition by using one or more supercritical upgrading reactors and one or more supercritical standby reactors that alternate functions such that the supercritical upgrading reactor is converted to a supercritical standby reactor and the supercritical standby reactor is converted to a supercritical upgrading reactor. The supercritical upgrading reactor upgrades a combined feed stream while a supercritical standby reactor delivers a cleaning fluid into the supercritical standby reactor. The supercritical reactors may have one or more catalyst layers and one or more purging fluid inlets, and the catalyst layers may have differing void volume ratios. |
| US10543461B2 |
Cartridge-type hollow fiber membrane module comprising submerged hollow fiber membrane unit module with free end and submerged apparatus for water treatment comprising air diffuser apparatus capable of intermittent/continuous aeration and its aeration method
Provided is a cartridge-type hollow fiber membrane module including a hollow fiber membrane unit module with a free end and a cartridge frame and a submerged water treatment apparatus including an air diffuser apparatus capable of intermittent and continuous aeration disposed below the hollow fiber membrane module, wherein the cartridge-type membrane module with the free end using the coarse bubble generating air diffuser apparatus capable of intermittent/continuous aeration in conjunction with an air accumulation pipe may control aeration/non-aeration cycles through adjustment of the volume of an air chamber and an amount of inflow air and carry out continuous aeration based on changes in raw water load and a concentration of solids in a membrane separation tank. |
| US10543455B2 |
Gas separation membrane, gas separation module, gas separation apparatus, gas separation method, and method for producing asymmetric gas separation membrane
A gas separation membrane has a gas separation layer containing a crosslinked cellulose resin. The crosslinked cellulose resin has a particular linking structure in a crosslinked structure. The gas separation layer contains an organic solvent in a particular amount. |
| US10543452B2 |
Removal of aromatic hydrocarbons from lean acid gas feed for sulfur recovery
The present invention is directed to a process for the removal of aromatic hydrocarbons from a lean acid gas containing less than 20 mol. % of H2S, comprising: a) contacting the lean acid gas stream (1) with a H2S-selective liquid absorbent solution (29) in a first absorption zone (2) to produce a gas stream depleted in H2S (3) and an absorbent solution enriched in H2S (4), b) introducing the absorbent solution (4) into a non-thermic stripping zone (8) where it is contacted with a stripping gas stream (7) to obtain an absorbent solution depleted in C4+ aliphatic and aromatic hydrocarbons (9) and a stripping gas stream enriched in aromatic and C4+ aliphatic hydrocarbons (10), c) contacting the stripping gas stream (10) obtained in step b) with a H2S-selective liquid absorbent solution (28) in a second absorption zone (12) to obtain a stripping gas stream depleted in H2S (13), and an absorbent solution enriched in H2S (14) d) introducing the absorbent solution (9) obtained in step b) into a desorption zone (16) wherein the H2S-selective liquid absorbent solution (17) is recovered and a lean acid gas is produced. |
| US10543450B2 |
Carbon dioxide recovery method and recovery apparatus
A carbon dioxide recovery apparatus has a separator which separates carbon dioxide from a gas by utilizing adsorption and desorption of carbon dioxide to and from an adsorbent caused by pressure fluctuation, the separator including a pressurizer which pressurizes the gas to a pressure that the adsorbent is capable of adsorbing carbon dioxide, and has a dryer having a hygroscopic agent for drying the gas. A regeneration system supplies the residual gas discharged from the separator to the dryer as a regeneration gas for regenerating the hygroscopic agent in the dryer, and the regeneration gas to be supplied to the dryer is heated by an energy converter by utilizing a pressure of a post-regeneration gas discharged by the regeneration of the hygroscopic agent. |
| US10543445B2 |
Air filtering device
An air filtering device for indicating when to replace the internal filter of an HVAC system. The air filtering device includes a frame having a plurality of sidewalls each having an upper end and a lower end. Each sidewall contains a plurality of slits that cycle air therethrough. A filter member is affixed to the upper end of the plurality of sidewalls, wherein the upper end containing the filter member is closed and the lower end is opened. Magnetic fasteners are affixed to the lower end of the plurality of sidewalls, wherein the magnetic fasteners removably secure to an outer perimeter of a return vent, such that the filter member overlays the grill of the return vent. In an alternate embodiment, a magnetic support member is affixed to a lower surface of the filter member at an equidistance from opposing sidewalls to prevent the filter member from touching the grill. |
| US10543444B2 |
Bag filters having controlled air permeability and dust collectors using the same
The present invention provides a dust collector which includes a chamber divided into an inlet chamber and a discharge chamber by a barrier, and a bag filter which is installed inside of the inlet chamber, and is formed in a shape having an inner space and an opening part by a filter medium, so as to communicate with the discharge chamber through the opening part, wherein a treatment gas is introduced into the inlet chamber and is filtered while passing through the filter medium of the bag filter, then moves to the discharge chamber through the opening part to be discharged, and the bag filter has air permeability decreased toward the opening part. According to the bag filter and the dust collector, it is possible to achieve a high collection performance and a stable operation even when using a long bag filter due to improvement of uniformity of the filtration velocity along the length of the bag filter. |
| US10543441B2 |
Filter media including adhesives and/or oleophobic properties
Articles and methods involving filter media are generally provided. In certain embodiments, the filter media includes at least a first layer, a second layer, and an adhesive resin positioned between the first layer and the second layer. In some embodiments, the first layer may be a pre-filter layer or a support layer. The second layer may, for example, comprise fibers formed by a solution spinning process and/or may comprise fine fibers. In some embodiments, the adhesive resin may be present in a relatively low amount and/or may have a low glass transition temperature. The filter media as a whole may have one or more advantageous properties, including one or more of a high stiffness, a high bond strength between the first layer and the second layer, a high gamma, and/or a low increase in air resistance after being subjected to an IPA vapor discharge. The filter media may be, for example, a HEPA filter and/or an ULPA filter. |
| US10543440B2 |
Reassembled liquid filtration assembly and method of manufacture
A method is disclosed. The method provides an assembly comprising a first core disposed within a housing, and replaces the first core with a second core. |
| US10543439B2 |
Site drainer
A liquid transfer device having a housing with a top end, a bottom end, a sidewall, and an inner cavity. The sidewall has an inner surface and an outer surface. There is a plurality of openings traversing said sidewall. Also present is a filtering surface that covers the openings. The water or other liquids are pumped or transferred with a pump contained inside the inner cavity, with a fluid exit used for carrying the water out towards exterior hosing. |
| US10543434B2 |
Method and system of increasing water and acid condensation from flue gas
The system and method spatially predict the condensation of water and acid from the flue gas in the condensing heat exchanger installed in fossil power plant flue gas treatment system or similar environment. By modifying the operational conditions, the heat exchanger can control rates and areas of condensations. The system and method adjust either the cooling water temperature or the flowrate ratio of flue gas to cooling water to control the condensation rates of water or acids. The system and method also estimate actual coverage areas to apply for anti-corrosive coating onto the tube or duct surfaces to resist corrosion due to acid condensation. The system and method also optimize or customize condensation rates of water and acids in boiler flue gas under operating conditions given at a power plant. |
| US10543432B2 |
Toy top
A toy top includes a shaft portion, a body, and a first attacking member and a second attacking member that are disposed at different circumferential direction positions of the body. The first attacking member is movable between an inner first position and an outer second position in a radial direction. The second attacking member is movable between an inner third position and an outer fourth position in the radial direction. The first attacking member is biased toward the first position and is movable to the second position by centrifugal force. The second attacking member is restrained at the third position when the first attacking member is at the first position and is released from restraint to be moved to the fourth position when the first attacking member is at the second position. |
| US10543430B2 |
Expanded field of view re-rendering for VR spectating
A method is provided: comprising: receiving, by a gaming server, game state data from a player client device, the game state data being defined from a game state of a first instance of a video game that is executed by the player client device; applying, by the gaming server, the received game state data and the view direction data to a second instance of the video game that is executed by the gaming server, to generate a wide field of view (FOV) spectator video; receiving, by a video server, view direction data from a spectator client device, the view direction data being determined from a tracked pose of a head-mounted display (HMD); applying, by the video server, the view direction data to define a portion of the wide FOV spectator video, the portion of the wide FOV spectator video identifying a sub-area of the wide FOV spectator video that is less than an entire area of the wide FOV spectator video; streaming the portion of the wide FOV spectator video to the spectator client device for rendering on the HMD. |
| US10543427B2 |
Game controller function remapping via external accessory
A game controller includes a plurality of controls, an accessory interface configured to removably affix an external accessory to the game controller, and a control mapping machine. The control mapping machine is configured to map a control of the plurality of controls to a first function while the external accessory is not affixed to the game controller, and map the control to a second function different than the first function while the external accessory is removably affixed to the game controller. |
| US10543426B2 |
Gaming system
Methods and systems for providing gaming services are provided. One system embodiment includes an operating system for executing a first and second instance of game logic for defining a game environment for a video game. The first and second instances game logic process game commands for a first and second user, respectively. A hardware GPU is configured for rendering video frames of a first video stream for the first game logic and video frames of a second video stream for the second game logic. Video frames of the first video stream are configured to be rendered on a display associated with the gaming system, and in some embodiments, without being encoded. An encoder of the system encodes the video frames of the second video stream, which are transmitted to a client device of the second user for game play. |
| US10543422B1 |
Providing synchronized and integrated video gaming
The synchronized and integrated architecture and method disclosed here provides a continuous visual experience for different players across different platforms and engages them at different levels as they access a particular game within a virtual gaming arena from the different platforms. Each of the players may have a unique and different visual experience, depending upon the gaming platform a player uses. The architecture facilitates access to video gaming applications via personal computers, via mobile devices, via game consoles, via tablets or the like. In some instances, a single player can play a particular game including a main component and a sub-component from the different platforms, where play in the sub-component is seamlessly integrated into the main component. |
| US10543420B2 |
Smog machine, method and apparatus for prompting state information of a physical game character, and remote-control fighting vehicle
A prompting device for prompting state information of a physical game character includes a smog machine and a control circuit. The smog machine include a smog chamber, a heating element, and an air-blowing device. The smog chamber has a receiving cavity for receiving smog fluid, an inlet, and an outlet. The inlet and the outlet are in communication with the receiving cavity. The heating element is mounted within the receiving cavity and generates heat to vaporize the smog fluid after an electric current is applied. The air-blowing device is disposed corresponding to the outlet for blowing an air flow towards the receiving cavity. The air flow generated by the air-blowing device enters into the receiving cavity from the inlet and discharges smog within the receiving cavity from outlet. The control circuit is configured to control the smog machine to generate the smog that characterizes the state information. |
| US10543419B2 |
Snowboard binding with adjustment memory
A binding for snowboard includes a base structure and a heel support pivotally mounted to the base structure for movement between an open position for allowing a user to insert or remove their boot from the binding and a closed position for securing the users boot in the binding. An adjustable foot strap is attached to the base structure and a tensioning system is attached to the heel support and the adjustable foot strap for applying a tensioning force to the adjustable strap when the heel support is moved to the closed position and for releasing the tensioning force from the adjustable foot strap when the seal support is moved to the open position. |
| US10543415B2 |
Recommendation engine
Generally, described are methods, apparatuses and systems for a recommendation engine which determines a recommendation based upon a terrestrial parameter and an overall factor unrelated to the terrestrial parameter. The recommendation engine may receive as inputs: (1) some data relating to the terrestrial parameter and (2) some data relating to user operation of a mechanical device. An overall factor may be calculated or obtained, at least in part, from the data relating to user operation of the mechanical device. And based upon the data relating to the terrestrial parameter and the overall factor, a recommendation may be determined and transmitted. In one embodiment, as part of the transmission process, the recommendation may be displayed to a user requesting the recommendation. |
| US10543413B2 |
Sports skills training apparatus
A training apparatus arranged to be portable, collapsible, and able to be configured into different arrangements for different nets and/or different sports-related activities. The training apparatus comprises a support portion, base poles pivotally coupled to the support portion, base brackets coupled to the base poles opposite the support portion, extensions coupled to the base brackets, first and second flexible rods removably coupled to the support portion, and a net configured to be received by the flexible rods. The net is configured to bend the first and second flexible rods from a linear state to an arcuate state, such that a net tension holds the net upright. |
| US10543410B2 |
Club heads for adjusting vertical spin of a golf ball and methods of providing the same
Some embodiments include a club head for adjusting vertical spin of a golf ball. Other embodiments of related systems and methods are also disclosed. |
| US10543409B2 |
Golf club head
Described herein is a golf club head that comprises a body and a strike plate. The body comprises a heel portion, a sole portion, a toe portion, and a top portion. The strike plate comprises an outer peripheral edge and at least a portion of a strike face. Furthermore, the strike plate is welded to the body via a peripheral weld between the outer peripheral edge of the strike plate and the body. The outer peripheral edge of the strike plate comprises at least one welded portion, welded to the body via the peripheral weld, and at least one non-welded portion, not welded to the body. |
| US10543408B2 |
Golf club heads with turbulators and methods to manufacture golf club heads with turbulators
A golf club head including a face defining a loft plane, a rear, and a crown, the crown having a turbulator comprising a plurality of ridges. Each ridge includes a front surface nearest the face, a rear surface nearest the rear, and an apex at a maximum height relative to the crown surface. The front surface of each ridge includes a concave curvature relative to the loft plane and a convex curvature relative to the loft plane. The ridge apex is positioned closer to the rear surface of the ridge than the front surface of the ridge. |
| US10543407B2 |
Golf club heads and methods to manufacture golf club heads
Embodiments of golf club heads and methods to manufacture golf club heads are generally described herein. In one example, a golf club head may include a body portion having a front portion, a rear portion, a toe portion, a heel portion, a bottom portion, a top portion, an interior, and a plurality of ports on the bottom portion. The golf club head may include a polymer insert in contact with an inner surface of the bottom portion. Other examples and embodiments may be described and claimed. |
| US10543402B2 |
Multi-piece golf ball
An object of the present invention is to provide a golf ball showing low spin rate on driver shots and high spin rate on approach shots. The present invention provides a multi-piece golf ball comprising a spherical center, at least two envelope layers covering the spherical center, and a cover covering the envelope layers, wherein the envelope layers comprise at least a first envelope layer covering the spherical center, and a second envelope layer covering the first envelope layer, a material hardness (H0) of the spherical center, a material hardness (H1) of the first envelope layer, and a material hardness (H2) of the second envelope layer satisfy an equation of H0>H1>H2, and the material hardness (H2) of the second envelope layer is lowest among the material hardness of the center constituent material and material hardness of envelope layer constituent materials. |
| US10543401B2 |
Resin composition for golf balls, and golf ball
A resin composition for golf balls includes specific amounts of (A) polyurethane or polyurea and (B) an oxazoline group-containing acrylic polymer or an oxazoline group-containing styrene polymer. A golf ball having a core encased by a cover of one or more layers, wherein at least one cover layer is formed of this resin composition, exhibits a good adhesion between adjoining layers, enabling the ball to achieve a high scuff resistance without lowering the initial velocity of the ball. |
| US10543400B2 |
Golf balls having core structures with iron-containing centers
Multi-piece golf balls having a solid core and cover are provided. The ball contains a small, heavy inner core and surrounding outer core layer. The inner core preferably contains metal powder such as copper, steel, brass, tungsten, titanium, nickel, iron, tin, and bronze particles dispersed in a thermoset or thermoplastic polymeric matrix. For example, a polybutadiene rubber matrix may be used. In one preferred embodiment, the inner core contains elemental iron powder. Preferably, the particles have a weight average size in the range of about 10 μm to about 450 μm. In one embodiment, the outer surface of the inner core has a structure with projecting members. For example, the outer surface may contain multiple projecting ribs with gaps located between the ribs. The ball includes a cover surrounding the core structure. The cover may be multi-layered. |
| US10543398B2 |
Wireless positioning apparatus and method, and sports training apparatus
A wireless positioning apparatus is disclosed, which includes at least one first device and at least one second device. Each first device is disposed on each moving object and is configured to transmit a wireless signal. Each second device is disposed on a fixed position and is configured to detect a strength of the wireless signal of each first device. The wireless positioning apparatus further includes a data processor, which is configured to receive the strength of the wireless signal of each first device detected by each second device, to calculate a distance between each first device and each second device, and to ultimately determine a position of each first device to thereby realize the positioning of each moving object. A wireless positioning method and a sports training apparatus comprising the wireless positioning apparatus are also provided in the disclosure. |
| US10543397B2 |
Exercise device
Disclosed herein is a resistance exercise device and methods of using the same. In one embodiment, a resistance exercise device is disclosed comprising a quarter-wheel, a means for attaching resistance to said quarter-wheel, a support means attached to the axis of the quarter-wheel, whereby a user can perform core exercise while moving in a direction parallel to the line of resistance. |
| US10543396B2 |
Exercise machine
Described herein are embodiments of stationary exercise machines having reciprocating foot and/or hand members, such as foot pedals that move in a closed loop path. Some embodiments can include reciprocating foot pedals that cause a user's feet to move along a closed loop path that is substantially inclined, such that the foot motion simulates a climbing motion more than a flat walking or running motion. Some embodiments can further include reciprocating handles that are configured to move in coordination with the foot via a linkage to a crank wheel also coupled to the foot pedals. Variable resistance can be provided via a rotating air-resistance based mechanism, via a magnetism based mechanism, and/or via other mechanisms, one or more of which can be rapidly adjustable while the user is using the machine. |
| US10543391B2 |
Exercise device and upright posture retainer for upper body
An upright posture retainer for upper body includes two upright retaining frames, and an adjusting device connected with the upright retaining frames and adjusted a distance between the upright retaining frames; wherein each of the upright retaining frames includes a resilient longitudinal retaining frame extended longitudinally and tending to recover an original upright state under stress, a shoulder retaining member and a leg retaining frame, wherein the shoulder retaining member is extended from an upper end of the resilient longitudinal retaining frame so as to form a shoulder contacting space, wherein the leg retaining frame is extended from an lower end of the resilient longitudinal retaining frame and transversely extended to form a leg retaining space, thereby contacting with the front of the human leg; wherein the adjusting device is fixed to the resilient longitudinal retaining frames of the upright retaining frames and supports the rear of upper body. |
| US10543387B2 |
Combustion arrester test systems and methods
Systems, kits, and methods for testing a combustion arrester are disclosed. Systems include an upstream chamber, a downstream chamber, and a combustion arrester between the upstream chamber and the downstream chamber. The upstream chamber includes an ignition port configured to receive an ignition source. And, the upstream chamber defines a convergent duct that converges toward the combustion arrester and terminates at the combustion arrester. The upstream chamber may include a hierarchical series of modular shell sections that define the convergent duct. The downstream chamber may include a series of modular shell sections. |
| US10543385B2 |
Methods for evaluating the stain removal efficacy of dentifrices
Disclosed herein are methods for evaluating the whitening effect of oral care composition on a stained egg comprising staining an eggshell, applying the oral care composition to a portion of the stained eggshell to obtain a treated eggshell area, calculating a ΔE value for the difference in color of the treated eggshell area compared to untreated stained eggshell when calculated in L*a*b color space, wherein the oral care composition comprises at least one high cleaning silica for stain removal. Further disclosed herein are methods for demonstrating the whitening effect of an oral care composition on a stained egg comprising showing an egg that has been stained to at least one consumer and brushing an oral care composition comprising at least one high cleaning silica for stain removal on a portion of the stained eggshell to obtain a treated eggshell area. |
| US10543380B2 |
Alignment of the coordinate systems of external beam radiotherapy and magnetic resonance imaging systems
The invention provides for a medical instrument (200, 300, 400, 500, 600, 700) comprising a magnetic resonance imaging system (204) operable for acquiring magnetic resonance data (266) from a subject (236) within an imaging zone (232) and an external beam radiotherapy system (202) operable for irradiating a target zone (238) within the imaging zone. The medical instrument further has a radiation beam generation system (208, 302, 302′, 302″) operable for generating a radiation beam (242, 304, 304′, 304″) and a radiation beam detection system (243, 502, 502′) operable for acquiring radiation beam detection data (270) descriptive of the radiation beam. Instructions cause a processor (248) controlling the instrument to receive (100) planning data (260) descriptive of a spatially dependent radiation dose and generate (102) external beam radiotherapy control commands (264) using the radiation dose. The instructions causes the processor to repeatedly: control (106) the external beam radiotherapy system to irradiate the target zone using the external beam radiotherapy system control commands; generate (108) the radiation beams using the radiation beam generation system; measure (110) the radiation beam detection data using the radiation beam detection system; acquire (112) the magnetic resonance imaging data using the magnetic resonance imaging system, generate (114) a magnetic resonance image (268) using the magnetic resonance image data, determine (116) a registration (274) of the magnetic resonance image to the radiation beam detection data; calculate (118) a mapping (276) using the registration; and modify the external beam radiotherapy system control commands using the mapping. |
| US10543377B2 |
Wearable cardioverter defibrillator (WCD) system making shock/no shock determinations by aggregating aspects of patient parameters
In embodiments, a WCD system includes one or more transducers that may sense patient parameters from different parts of the patient's body, and thus render physiological inputs from those parameters. Individual analysis scores may be determined from the physiological inputs, and an aggregate analysis score may be determined from the individual analysis scores. A shock/no shock determination may be made depending on whether or not the aggregate analysis score meets an aggregate shock criterion. Accordingly, multiple inputs are considered in making the shock/no shock determination. |
| US10543371B2 |
Systems and methods for alerting auditory prosthesis recipient
An alert system detects when an auditory prosthesis recipient is wearing her sound processor. When the processor is not worn, the alert system signals a secondary device, such as an accessory, to provide some other form of tactile stimulation to allow the recipient to be made aware of certain auditory stimuli she is not receiving via the auditory prosthesis. Thus, the alert system can effectively “hear” for the recipient. Since many auditory prosthesis recipients are, for all practical purposes, completely deaf without their external sound processors attached and operational, such an alert system increases the recipient's safety, convenience, and quality of life. |
| US10543370B2 |
Method and device to manage modifications of protected registers in an implantable medical device
Circuits, devices and methods are provided to manage modifications to protected registers within an implantable medical device (IMD). The circuit comprises a bus controller that includes an address register, an unlock register and a protected register (PR) enable unit. The PR enable unit sets a protect enable signal to an access state based on content loaded into the unlock register. A peripheral block includes a protected register that retains content for operating the IMD. The peripheral block includes a register access input to receive the protected enable signal. A PR write control unit is provided to enable an attempted write of the content from a data interface to the protected register when the protected enable signal has an access state. |
| US10543367B2 |
Transcranial burst electrostimulation apparatus and its applications
The invention provides transcranial electrostimulation by combining transcranial direct current stimulation (tDCS) and theta burst stimulation (TBS) to achieve an unexpected therapeutic effect in various brain or neural diseases. Accordingly, the invention provides a mode of direct current with biphasic square wave pulses in the treatment of brain or neural diseases. Also provided are methods of employing the transcranial electrostimulation of the invention and applications of the transcranial electrostimulation of the invention. |
| US10543366B2 |
Percutaneous access for systems and methods of treating sleep-related disordered breathing
Systems and methods are described and illustrated for percutaneously implanting a stimulation lead for treating sleep-related disordered breathing. |
| US10543365B2 |
Functional electrical stimulation systems
A gait modulation system including: (a) a sensor device including a sensor adapted for associating with at least one lower limb of the patient, the sensor for transducing at least one parameter related to a gait of the patient, so as to obtain gait data related to the gait, and (b) a muscle stimulator including: (i) an electrical stimulation circuit, the circuit adapted to supply an electrical stimulation output to an electrode array for performing functional electrical stimulation of at least one muscle of the lower limb, and (ii) a microprocessor, operatively connected to the at least one sensor, the microprocessor adapted for: receiving a stream of gait information based on the gait data; processing the gait information, and controlling the stimulation output based on the processing of the gait information, and wherein the microprocessor is further adapted to identify a failure in the stream of gait information, and to consequently control the electrical stimulation circuit to deliver a fail-safe stimulation output over a portion of a duration of the failure. |
| US10543363B2 |
Transvascular medical lead
A medical electrical lead and methods of implanting medical electrical leads in lumens. Leads in accordance with the invention employ preformed biases to stabilize the lead within a lumen or lumen and to provide feedback to lead implanters. |
| US10543362B2 |
Symmetrical output neurostimulation device
A method and system of providing therapy to a patient using electrodes implanted adjacent tissue. The method comprises regulating a first voltage at an anode of the electrodes relative to the tissue, regulating a second voltage at a cathode of the electrodes relative to the tissue, and conveying electrical stimulation energy between the anode at the first voltage and the cathode at the second voltage, thereby stimulating the neural tissue. The system comprises a grounding electrode configured for being placed in contact with the tissue, electrical terminals configured for being respectively coupled to the electrodes, a first regulator configured for being electrically coupled between an anode of the electrodes and the grounding electrode, a second regulator configured for being electrically coupled between an anode of the electrodes and the grounding electrode, and control circuitry configured for controlling the regulators to convey electrical stimulation energy between the anode and cathode. |
| US10543359B2 |
Seizure detection algorithm adjustment
A medical system implements a seizure detection algorithm to detect a seizure based on a first patient parameter. The medical system monitors a second patient parameter to adjust the seizure detection algorithm. In some examples, the medical system determines whether a seizure for which therapy delivery is desirable occurred based on a second patient parameter. If a target seizure occurred, and the seizure detection algorithm did not detect the target seizure, the medical system adjusts the seizure detection algorithm to detect the target seizure. For example, the medical system may determine a first patient parameter characteristic indicative of the target seizure detected based on the second patient parameter and store the first patient parameter characteristic as part of the seizure detection algorithm. In some examples, the first patient parameter is an electrical brain signal and the second patient parameter is patient activity (e.g., patient motion or posture). |
| US10543357B2 |
High voltage connectors for pulse generators
An electrode connectable to a pulse generator is disclosed. The electrode includes therapeutic terminals configured to deliver the pulse to a patient, first and second electrical pulse inlet holes, and a first pulse input terminal. The first pulse input terminal is in the first electrical pulse inlet hole and is spaced apart from an entrance to the first electrical pulse inlet hole by more than about 2.5 cm. Also, first pulse input terminal is connected with one or more of the therapeutic terminals. The electrode also includes a second pulse input terminal, where the second pulse input terminal is in the second electrical pulse inlet hole and is spaced apart from an entrance to the second electrical pulse inlet hole by a distance greater than about 2.5 cm. Also, the second pulse input terminal is electrically connected with one or more of the therapeutic terminals. |
| US10543352B2 |
Coupling device and method for using the same
The present invention relates to a connector system for use in connecting conduits together, such as those used with an extracorporeal blood circulation system. The system has a male and female connector and a seal. The seal is operatively associated with the male and female connectors and forms a fluid tight connection between the male and female connectors. An inner surface of the seal and the inner surfaces of the first and second coupling ends form a continuous and smooth transitional surface. |
| US10543351B2 |
Ported catheter adapter having combined port and blood control valve with venting
A ported catheter adapter having a combined blood control valve and port valve, wherein the combined valve comprises one or more vents that permit the passage of air and prevent the passage of fluids. The one or more vents are located on the outer surface of the valve so as to avoid being overlapped with the pathway of the side port. As such, fluid communication between the side port and the vents is prevented. Various venting configurations are provided. The invention further includes a valve actuator that is advanced through a slit in the membrane of the valve to provide a pathway for fluid to bypass the valve. |
| US10543349B2 |
Device for piercing an organic tissue and actuation module
The invention relates to a device for piercing an organic tissue, and more particularly to piercing human or animal skin. The device includes a housing, a piercing unit, which is accommodated in the housing, and an actuator device which is arranged and configured in the housing to generate an actuating force in such a way that an actuator component surrounded by the actuator device and functionally connected to the piercing unit, performs an oscillating actuating movement in the housing which is coupled to the piercing unit. The actuating device is designed with a counter component allocated to the actuating component which at least partially compensates for vibrations caused in the housing by the oscillating actuating movement of the actuating component; the counter component oscillates and is moved contrary to the actuating component. The invention also relates to an actuation module for a device for piercing an organic tissue. |
| US10543347B2 |
Delivery system for percutaneous absorption drug preparation and method for manufacturing same
Provided is a novel delivery system for a percutaneous absorption drug preparation. The delivery system for a percutaneous absorption drug preparation is provided with: a solvent-impermeable first sheet; a solvent-impermeable second sheet that is bonded to the top surface of the first sheet and comprises a non-sealed area and a sealed area surrounding the non-sealed area, said non-sealed area and sealed area being formed between the first sheet and the second sheet, and a cutting part circularly extending along the outer peripheral edge of the non-sealed area; a percutaneous absorption drug preparation-holding member that is disposed between the first sheet and the second sheet in the non-sealed area and fixed to the second sheet inside the cutting part; and a pressure-sensitive adhesive third sheet that is removably bonded to the top surface of the second sheet. |
| US10543342B2 |
Expandable introducer sheath
The invention relates to an introducer sheath for catheters to be inserted into a vascular system comprising a connecting valve (2) and an insertion tube (3) having a proximal portion (4) and a distal portion (5), said distal portion (5) being of reduced diameter in comparison with the proximal portion (4), and to enable its diameter to be reversibly changed the insertion tube (3) is provided with longitudinally extending expansion elements with incisions (11, 11′, 12) designed as predetermined breaking points. |
| US10543338B2 |
Method and apparatus for removable catheter visual light therapeutic system
A medical device assembly is provided for removable insertion into a catheter with a lumen. The medical device assembly comprises an electromagnetic radiation (EMR) source for providing non-ultraviolet, therapeutic EMR having an intensity sufficient to inactivate one or more infectious agents and/or to stimulate healthy cell growth causing a healing effect, and a removable EMR conduction system at least partially insertable into and removable from the lumen of the catheter. The EMR conduction system has at least one optical element providing axial propagation of the therapeutic EMR through an insertable elongate body. The elongate body may have an exterior surface between a coupling end and a distal end tip that has at least one modified portion permitting the radial emission of therapeutic EMR from the elongate body proximate the modified portion. Such modified portion may be gradient along the exterior surface. |
| US10543333B2 |
Mask vent
A vent arrangement is provided to a mask or associated conduit to discharge exhaled gas from the mask to atmosphere. The vent arrangement is structured to diffuse the exhaust vent flow to produce less air jetting, thereby increasing the comfort of the patient and their bed partner. For example, the vent arrangement may include one or more grill components and/or media constructed and arranged to diffuse vent flow. |
| US10543331B2 |
Fluid delivery system to airway
A fluid delivery system is provided including an elongated member with a lumen, a first portion, a second portion, and a third portion, wherein the second portion is disposed between the first portion and the third portion. The elongated member is insertable into a patient's mouth such that the second portion is disposed entirely within the patient's mouth while the first portion and third portion extend from a point inside the patient's mouth to a point external the patient's mouth. The fluid delivery system also includes a locking system slidably engaged with the elongated member, the locking system removably engageable with the patient's teeth. Further, the second portion is configured to allow drainage of a fluid from within the lumen to a point external the elongated member. |
| US10543325B2 |
Enhanced performance verification port for therapeutic gas delivery
Therapy gas delivery systems that provide run-time-to-empty information to a user of the system and methods for administering therapeutic gas to a patient. The therapeutic gas delivery system may include a gas pressure sensor attachable to a therapeutic gas source that communicates therapeutic gas pressure data to a therapeutic gas delivery system controller, a gas temperature sensor positioned to measure gas temperature in the therapeutic gas source that communicates therapeutic gas temperature data to the therapeutic gas delivery system controller, at least one flow controller that communicates therapeutic gas flow rate data to the therapeutic gas delivery system controller, at least one flow sensor that communicates flow rate data to the therapeutic gas delivery system controller, and at least one display that communicates run-time-to-empty to a user of the therapeutic gas delivery system. The therapeutic gas delivery system controller of the system includes a processor that executes an algorithm to calculate the run-time-to-empty from the data received from the gas pressure sensor, temperature sensor, flow controller and flow sensor, and directs the result to the display. |
| US10543324B2 |
Inhaler with a pinch clamp
An inhaler comprising a reservoir of an inhalable composition with an outlet at one end through which the inhalable composition is discharged. A non-metered breath-activated valve is provided between the one end and the reservoir, the breath-activated valve comprising a flow path extending from the reservoir to the outlet end. At least a portion of the flow path is a deformable tube. A clamping member pinches the deformable tube closed when no suction force is applied to the device and releases the tube to open the flow path when suction is applied at the outlet, to provide uninterrupted flow from the reservoir to the outlet. |
| US10543323B2 |
Inhaler
The present disclosure relates to an inhaler component for producing a steam/air mixture or/and condensation aerosol in an intermittent and inhalation- or pull-synchronous manner, the inhaler component including: a housing; a chamber arranged in the housing; an air inlet opening for the supply of air from the surroundings to the chamber; an electrical heating element for evaporating a portion of a liquid material; and a wick having a capillary structure, which wick forms a composite structure with the heating element and automatically supplies the heating element with fresh liquid material after evaporation. |
| US10543322B2 |
Injection needle assembly for an injection device and an injection device comprising such assembly
An injection needle assembly (50) for an injection device, having a) a needle cannula (3) attached to a needle hub (4) and defining a pointed tip at a free end (3a, 3b), and b) a needle cover (10, 10a, 10b) forming an axially extending elongated flexible enclosure accommodating the needle cannula (3). The needle cover (10, 10a, 10b) is configured to axially collapse and become penetrated by the needle cannula (3) when a penetration force is applied to the needle cover. The needle cover (10, 10a, 10b) defines a shaft section (11a) and a bulb section (11b). The shaft section (11a) encircles the needle cannula (3) and extends axially from the needle hub (4) to the bulb section (11b). The shaft section (11a) comprises a collapsible wall area (15) having wall thickness t1 less than a predefined wall thickness t1,lim to provide radial deformability for abutting contact with the needle cannula (3). |
| US10543318B2 |
Plastic stopper
A stopper includes a main body portion defining an open rearward end configured to receive the plunger rod, an engagement portion provided along an inner circumference of the main body portion configured to engage at least a top portion of the plunger rod, a closed front end forming a flexible roof, and a first perimetrical skirt extending around an outer circumference of the main body portion toward the closed front end of the main body portion. When fluid pressure is increased inside the syringe barrel during an injection, the flexible roof expands in a radial direction toward an inner wall of the syringe barrel, the first perimetrical skirt is forced against the inner wall of the syringe barrel, and an engagement between the plunger rod and the engagement portion forces the main body portion to expand in the radial direction toward the inner wall of the syringe barrel. |
| US10543317B2 |
Prefilled disposable injection device
The present invention relates to a drug delivery device comprising a drug container having at least one bellow. The at least one bellow has a first surface and an opposing second surface. The first surface is comprised of a first Belleville spring and the opposing second surface is comprised of a second Belleville spring, wherein the second Belleville spring has a higher spring rate than the first Belleville spring. |
| US10543315B2 |
Multi-chambered vessels
Described are multi-chambered vessels comprising a first chamber, a second chamber, and a seal comprising a first member and a second member, wherein the first and second members are engageable with one another to form a barrier separating the first and second chambers. The first and second members are disengageable from one another to open a channel between the first chamber and second chambers. The vessels allow communication between the first and second chambers at a desired time, for example in order to contact components contained within the chambers or in order to sequentially release components or doses of components from the vessel. Also provided is a kit comprising a seal of the invention. The kit allows a single-chambered vessel to be converted into a multi-chambered vessel capable of controlling communication between the chambers at the final stage of the filling process. |
| US10543311B2 |
Methods and tools relating to the administration of contrast medium
Envisaged herein are methods for determining the optimal volume of contrast medium to be administered to a patient. More particularly, the methods envisaged herein comprise the steps of (a) measuring one or more patient-specific physiological parameters, said one or more patient-specific physiological parameters comprising at least the patient's heart rate; and (b) determining the optimal volume of contrast medium based on the patient-specific physiological parameters determined under (a). |
| US10543310B2 |
Delivering and/or receiving material with respect to a subject surface
The present invention generally relates to receiving bodily fluid through a device opening. In one aspect, the device includes a flow activator arranged to cause fluid to be released from a subject. The flow activator may be actuated in a deployment direction by a deployment actuator, which may in turn cause fluid release from a subject. The flow activator may also be moved in a retraction direction by a retraction actuator. In one aspect, the device may include a vacuum source that may help facilitate fluid flow into the opening of the device and/or may help facilitate fluid flow from the opening to a storage chamber. In one aspect, an effector may enable fluid communication between the opening and the vacuum source and may do so in response to actuation of the flow activator. |
| US10543301B2 |
Heart pump
A heart pump including: a housing forming a cavity including: at least one inlet aligned with an axis of the cavity; and, at least one outlet provided in a circumferential outer wall of the cavity; an impeller provided within the cavity, the impeller including vanes for urging fluid from the inlet to the outlet; and, a drive for rotating the impeller in the cavity and wherein a flow path through the pump has a minimal cross-sectional area of at least 50 mm2. |
| US10543300B2 |
Adaptable wound drainage system
Provided are drainage systems that may include a drainage manifold and may be suitable for draining fluid from a tissue site. The drainage manifold may include a plurality of elongate members having a moveable end that may be adapted to configure the drainage manifold to treat a uniquely shaped tissue site. The drainage manifold may be coupled to a drainage tube with a transitional connector to provide a drainage system capable of distributing reduced pressure to the tissue site to enhance the drainage of fluids. |
| US10543295B2 |
Particles
Embolic particles are described. The particles are reaction products of a prepolymer solution including at least one polyether macromer and an appropriate monomer. |
| US10543293B2 |
Medical dressing
The present invention relates to a medical dressing that has a modular structure consisting of at least two layers and that is able to cleave incorporated photolabile nitric oxide donors in an adjoining absorption module by means of the emission of electromagnetic radiation from a light module, so that the photolytically generated nitric oxide can be used to enhance medical therapies in humans and animals as well as to generate NO. |
| US10543291B2 |
Cell for ultraviolet irradiation module and ultraviolet irradiation module
The present invention is intended to provide a cell for an ultraviolet irradiation module and an ultraviolet irradiation module with which it is possible to improve the efficiency of sterilizing an object to be irradiated to a greater extent than in the past. The cell for an ultraviolet irradiation module includes a case being at least partially formed of polytetrafluoroethylene having a crystallite size in a direction of 60 nm or more and 250 nm or less and having an internal space into which an object to be irradiated can be introduced. |
| US10543289B2 |
Method and apparatus for rapid sterilization
Methods and systems for sterilizing a tools and equipment are disclosed, including using a UV source to generate a pulsed UV light within or exterior to an enclosure having a highly reflecting diffuse inner coated surface; and absorbing the pulsed light to sterilize. Other embodiments are described and claimed. |
| US10543278B2 |
Immunoparticles and methods of generating and using same
A pharmaceutical composition comprising an immunoparticle is provided. The pharmaceutical composition comprising a monoclonal secondary antibody immunocomplexed with a primary antibody, wherein said monoclonal secondary antibody is coupled on an outer surface of a particle and wherein said particle is loaded with a pharmaceutical agent. |
| US10543275B2 |
Composition for patch preparation comprising drug, organic solvent, lipophilic mass base, and powder
The present disclosure provides a composition for a non-aqueous patch preparation with excellent adhesibility which can sustainedly release a drug. The patch preparation can improve the adhesibility of the patch preparation and the release property of a drug by the addition of a powder ingredient the long-time sustention of the adhesibility of tape preparations enables an improvement of the transdermal absorbability and the sustained release of a drug. |
| US10543274B2 |
Lyophilized preparation of cytotoxic dipeptides
The present invention is directed to novel lyophilized pharmaceutical preparations comprising a cytotoxic dipeptides such as melphalan flufenamide and one or more excipient(s) selected from the group comprising a polysorbate; a polyethylene glycol; β-cyclodextrin; ocyclodextrin; hydroxypropyl-β-cyclodextrin; sulfobutylether-β-cyclodextrin; lactose; benzyl alcohol; disodium succinate; propylene glycol; Cremophor EL; Dimethyl sulfoxide; D-mannitol; Trehalose; Sucrose and an amino acid. This preparation may be further formulated and is useful in cancer therapy. |
| US10543272B2 |
Use of aminolevulinic acid and derivatives thereof
The invention provides the use of a photosensitiser which is a derivative (e.g. an ester) of 5-aminolevulinic acid (5-ALA), or a pharmaceutically acceptable salt thereof, in the manufacture of a composition for use in methods of photodynamic therapy (PDT) on an animal, wherein said PDT comprises: (a) administering to said animal a composition comprising said photosensitiser; and (b) photoactivating said photosensitiser, and side-effects (e.g. pain and/or erythema) of said PDT are prevented or reduced by use of one or more of (i)-(iv): (i) said composition comprises said photosensitiser in a concentration of less than 10% wt (e.g. 0.5 to 8% wt), (ii) said composition is administered for less than 2 hours (e.g. 30 minutes to 90 minutes) prior to said photoactivation, (iii) said photoactivation is carried out with a light source having a fluence rate of less than 50 mW/cm2 (e.g. 5 to 40 mW/cm2), (iv) said photoactivation is carried out with sunlight. Preferably, side effects of PDT are prevented or reduced by using (ii) or (iv) in combination with (i) and/or (ii). |
| US10543268B2 |
Genetically engineered swine influenza virus and uses thereof
The present invention relates, in general, to attenuated swine influenza viruses having an impaired ability to antagonize the cellular interferon (IFN) response, and the use of such attenuated viruses in vaccine and pharmaceutical formulations. In particular, the invention relates to attenuated swine influenza viruses having modifications to a swine NS1 gene that diminish or eliminate the ability of the NS1 gene product to antagonize the cellular IFN response. These viruses replicate in vivo, but demonstrate decreased replication, virulence and increased attenuation, and therefore are well suited for use in live virus vaccines, and pharmaceutical formulations. |
| US10543267B2 |
Neisseria meningitidis compositions and methods thereof
In one aspect, the invention relates to a composition including a factor H binding protein (fHBP) and a Neisseria meningitidis non-serogroup B capsular polysaccharide. The invention further relates to uses of a composition that includes fHBP, such as, for example, uses to elicit an immune response against N. meningitidis serogroup B strains and non-serogroup B strains. The compositions and methods described herein are directed to administration in humans, including adults, adolescents, toddlers, and infants. |
| US10543261B2 |
DNA vaccine containing VEGF-specific epitope and/or angiopoietin-2-specific epitope
The present invention provides a therapeutic or prophylactic agent for cancer, containing an expression vector encoding a chimeric Hepatitis B virus core antigen polypeptide inserted with an amino acid sequence containing a specific epitope of VEGF and/or a specific epitope of angiopoietin-2, wherein the amino acid sequence containing the specific epitope is inserted between the amino acid residues 80 and 81 of the hepatitis B virus core antigen polypeptide. |
| US10543260B2 |
Replacement gene tolerizing vectors and methods of use thereof
The instant disclosure provides replacement gene tolerizing vectors and methods of using such vectors for treating individuals receiving gene therapy for muscular dystrophy, e.g., Duchenne muscular dystrophy (DMD), Becker muscular dystrophy (BMD), etc. Aspects of the methods include administering to the individual, in need thereof, an effective amount of a gene therapy tolerizing vaccine composition that includes a replacement gene tolerizing vector to reduce one or more symptoms of a subject's immune response to gene therapy treatment for muscular dystrophy and/or improve the efficacy of the gene therapy. Compositions and kits for practicing the methods of the disclosure are also provided. |
| US10543258B2 |
Antibacterial composition containing ADK protein as active ingredient, or composition for preventing or treating sepsis
The present invention relates to an antibacterial composition containing, as an active ingredient, adenylate kinase or adenosine kinase (ADK) protein derived from Mycobacterium tuberculosis, and a composition for preventing or treating infectious diseases. In addition, the present invention relates to a composition for preventing or treating sepsis or septic shock. Furthermore, the present invention relates to a method for preventing, improving or treating an infectious disease comprising administering the present antibacterial composition. The ADK protein derived from Mycobacterium tuberculosis according to the present invention has excellent antibacterial activity selectively against gram-negative bacteria, and thus can be favorably used as an antibacterial composition against gram-negative bacteria or for the prevention or treatment of infectious diseases caused by gram-negative bacteria. In addition, the ADK protein has an excellent sepsis treatment effects, thus can be favorably used for the prevention or treatment of sepsis or septic shock. |
| US10543257B2 |
Lentiviral vector for treating hemoglobin disorders
The invention is directed to a more efficient lentiviral vector comprising a nucleic acid sequence encoding a human β-globin protein or a human γ-globin protein, which is oriented from 5′ to 3′ relative to the lentiviral genome. The invention also provides a composition and method utilizing the lentiviral vector. |
| US10543256B2 |
Stable pharmaceutical formulation comprising a reconstituted pulmonary surfactant composition
Physically and chemically stable pharmaceutical formulations in the form of an aqueous suspension comprising a reconstituted pulmonary surfactant are useful for the prophylaxis and/or treatment of respiratory distress syndrome (RDS) and other respiratory disorders. |
| US10543248B2 |
Pharmaceutical composition having preventative or treatment effect on inflammatory bowel diseases comprising stemonae radix extract
The present invention relates to a pharmaceutical composition, which comprises a Stemonae Radix extract, for preventing or treating the occurrence of inflammatory bowel diseases due to cigarette smoke, a method for preventing or treating the occurrence of inflammatory bowel diseases using the composition, a method for suppressing the expression of inflammatory cytokines using the composition, and to a food composition, which comprises the Stemonae Radix extract, for preventing or treating the occurrence of inflammatory bowel diseases due to cigarette smoke. The pharmaceutical composition comprising the Stemonae Radix extract, according to the present invention, reduces the level of MMP12 expression that is known to destroy IL-1β, TNF-α, and IL-6, which are inflammatory cytokines that accompany the inflammatory bowel diseases, and elastin and collagen, and can suppress decrease in the number of lactobacilli in the intestine, and thus can be widely used in developing a safe and effective inflammatory bowel diseases treating agent. |
| US10543245B2 |
Composition for preventing or treating hyperlipidemia
A method for preventing or treating hyperlipidemia includes administrating a composition consisting of a Salvia miltiorrhiza extract, a Crataegus pinnatifida extract, a Polygonum multiflorum extract, and a Ligusticum chuanxiong extract to a subject in need thereof. The composition may reduce an amounts of serum cholesterol and LDL-cholesterol and increase an amount of HDL-cholesterol, significantly reduce an amount of serum triglyceride compared with existing statin-based drugs, thereby exhibiting prophylactic and therapeutic effects of hyperlipidemia with various symptoms even without the co-administration of other drugs; and reduce an amounts of hepatic to cholesterol and triglyceride, thereby exhibiting an effect of inhibiting fatty liver. |
| US10543239B2 |
Lactic acid bacteria and bifidobacteria for treating endotoxemia
The invention relates to use of a bacterium selected from a lactic acid bacterium, a Bifidobacterium or a mixture of any thereof for treating metabolic endotoxemia, inhibiting bacterial translocation and regulating lipid absorption in a mammal. |
| US10543234B2 |
Methods and compositions for modulating peripheral immune function
Disclosed herein are cell preparations useful for modulating various peripheral immune functions, methods for making said cell preparations, and methods for their use. |
| US10543231B2 |
Methods and materials for treating cancer
This document provides methods and materials involved in treating cancer. For example, methods and materials involved in making and using particles (e.g., gold nanoparticles) containing a KTLLPTPYC amino acid sequence (SEQ ID NO:1) or a KTLLPTPYCC amino acid sequence (SEQ ID NO:2) to treat cancer (e.g., pancreatic cancer) are provided. |
| US10543230B2 |
Redox signaling gel formulation
Redox signaling gels are disclosed. Such gels include a composition with at least one reactive oxygen species (ROS) and a rheology modifier. Also presented herein is a process for making the gels which includes making the composition by taking the steps of purifying water to produce ultra-pure water, combining a salt to the ultra-pure water to create a salinated water, electrolyzing the salinated water at a temperature of 4.3 to 5.8° C. such that the electrolyzing is accomplished with an anode, cathode and power source such that the power source comprises a transformer and a rectifier and does not comprise a filter capacitor. |
| US10543229B2 |
Dietary supplement composition as a prophylactic and treatment for skin diseases such as eczema and psoriasis and the like and method of treatment
A dietary supplement composition as a prophylactic and treatment for skin diseases such as eczema and psoriasis and the like, the composition comprising a phase II liver detoxification component having glycine, and magnesium, wherein glycine and magnesium are present in the supplement composition in a ratio of between about 20:1 and 20:8. |
| US10543228B2 |
Pharmaceutical preparation containing selenite or selenite-containing compounds for treating cervical dysplasia or carcinomas
The invention relates to compositions containing selenite-containing compounds and pharmaceutically acceptable acids, selected from citric acid, acetic acid, malic acid, carbonic acid, sulphuric acid, nitric acid, hydrochloric acid, fruit acids or mixtures thereof, for use for treating cervical inflammations, dysplasia and/or carcinomas. The invention further relates to methods of using such compositions. |
| US10543227B2 |
Hair growth composition
The invention of this application relates to a composition for growing hairs comprising, as an active ingredient, thiosulfuric acid or a salt thereof that has hair growing effects and has no side effects. |
| US10543219B2 |
Oral testosterone ester formulations and methods of treating testosterone deficiency comprising same
A pharmaceutical formulation of testosterone undecanoate is provided. Methods of treating a testosterone deficiency or its symptoms with the inventive formulations are also provided. |
| US10543215B2 |
Combination therapy of cardiac myosin activator and sinus node if current inhibitor
Disclosed herein are combination therapies for the treatment of heart failure using a cardiac myosin activator, such as omecamtiv mecarbil, and a sinus node If current inhibitor, such as ivabradine. Also disclosed herein are compositions comprising a cardiac myosin activator and a sinus node If current inhibitor. |
| US10543212B2 |
Substituted amines for treating cardiac diseases
The present invention provides a compound having a CaMKII inhibitory action, which is expected to be useful as an agent for the prophylaxis or treatment of cardiac diseases (particularly catecholaminergic polymorphic ventricular tachycardia, postoperative atrial fibrillation, heart failure, fatal arrhythmia) and the like.The present invention relates to a compound represented by the formula (I): wherein each symbol is as defined in the specification, or a salt thereof. |
| US10543211B2 |
Methods and compositions for treating diseases and conditions
Provided herein include methods and compositions for treating diseases or conditions. In some embodiments provided are methods for treating one or more diseases or conditions selected from the group consisting of hypertension, heart failure, dyspnea, and sleep apnea. In certain embodiments provided are methods that include administering a compound of formula (I) as disclosed herein. In some embodiments provided are methods that include administering a P2X3 and/or a P2X2/3 receptor antagonist. |
| US10543210B2 |
Inhibitors of multidrug resistance transporter P-glycoprotein
The present disclosure provides a method of treating a subject that is resistant to one or more drugs by identifying a subject having one or more drug resistant cells; administering to the subject a pharmaceutically effective amount of an inhibitor compound, and contacting one or more drug resistant cells with the inhibitor compound to reduce the export of the inhibitor compound from the one or more drug resistant tumor cells and to block the transport of drug(s) from the one or more drug resistant cells. |
| US10543209B2 |
Dihydropyridophthalazinone inhibitors of poly(ADP-ribose)polymerase (PARP)
A compound having the structure set forth in Formula (I) and Formula (II): wherein the substituents Y, Z, A, B, R1, R2, R3, R4 and R5 are as defined herein. Provided herein are inhibitors of poly(ADP-ribose)polymerase activity. Also described herein are pharmaceutical compositions that include at least one compound described herein and the use of a compound or pharmaceutical composition described herein to treat diseases, disorders and conditions that are ameliorated by the inhibition of PARP activity. |
| US10543204B2 |
Use of Hsp70 as a regulator of enzymatic activity
The present invention concerns a method for modulating the enzymatic activity of an enzyme, wherein said enzyme interacts with BMP, said method comprising the step of administering or inducing Hsp70, or a functional fragment or variant thereof, in a form suitable for allowing interaction between BMP and Hsp70, or said functional fragment or variant thereof, and thereby modulating the enzymatic activity of an enzyme interacting with BMP. |
| US10543201B2 |
Compositions and methods for treating pelvic pain and other conditions
Methods are provided for treating conditions including chronic pelvic pain, in which there are palpable trigger points of local areas of muscle restriction and spasticity that recreate or refer pain of patients complaints upon palpation, chronic pelvic pain syndrome, pelvic floor myalgia, pelvic floor dysfunction, interstitial cystitis, levator ani syndrome, coccygodynia, prostatodynia, piriformis syndrome, anal sphincter pain, bowel movement pain, post bowel movement pain, ejaculatory pain, post ejaculatory pain, sitting pain, post bowel movement pain, rectal pain, tailbone pain, urinary frequency, urinary urgency, urinary hesitancy, post urinary pain, overactive bladder, perineal pain, penile pain, vaginismus, anismus, sexual dysfunction, reduced level of ejaculate or reduced penile erection, myofascial pain in muscle tissue of a patient who has one or more trigger points in the muscle tissue, or the pain/sensitivity of pelvic floor muscle trigger points and specific areas of myofascial restriction detected upon palpation in a patient comprising administering to the one or more trigger points of the patient in need thereof a therapeutically effective amount of a calcium channel blocker, or L-arginine, or a combination of a calcium channel blocker and L-arginine, or pharmaceutically acceptable salts, hydrates, solvates and prodrugs thereof; the application of the topical form of the drug can be applied by the patient regularly as part of a self treatment program to heal muscle related pain and muscle related pelvic pain and each optionally together with a corticosteroid such as cortisone of hydrocortisone. The invention further provides methods for myofascial release, trigger point release, and the use of dilators with and without calcium channel blockers for pain conditions. The invention further provides pharmaceutical compositions, kits and applicator devices useful in the methods of the invention. |
| US10543197B2 |
Phosphoinositide 3-kinase inhibitor with a zinc binding moiety
The invention provides a compound of Formula I, Pharmaceutical compositions comprising such compounds and the use of such compounds in the treatment of phosphoinositide 3-kinase related diseases and disorders such as cancer. The instant application further relates to the treatment of histone deacetylase related disorders and diseases related to both histone deacetylase and phosphoinositide 3-kinase. |
| US10543195B2 |
Peptides for skin rejuvenation and methods of using the same
The invention provides compositions for stimulating the formation of one or more extracellular matrix components that contain a lipoaminoacid derivative of the tripeptide carnosine such as N-Octanoyl Carnosine. Also provided are compositions containing N-Octanoyl Carnosine in combination with selected tripeptide and/or tetrapeptides as well as pharmaceutical and/or cosmetic compositions containing such compositions. The invention further provides methods of using the compositions and compositions of the invention to treat, alleviate, and/or ameliorate a symptom, condition, disorder, or disease of the skin or mucosa, wherein the symptom, condition, disorder, or disease is associated with changes in extracellular matrix components. |
| US10543193B2 |
Processes useful for the preparation of 1-[3-(4-bromo-2-methyl-2H-pyrazol-3-yl)-4-methoxy-phenyl]-3-(2,4-difluoro-phenyl)-urea and crystalline forms related thereto
The present invention is directed to processes and intermediates useful for the preparation of 1-[3-(4-bromo-2-methyl-2H-pyrazol-3-yl)-4-methoxy-phenyl]-3-(2,4-difluoro-phenyl)-urea (Compound I), crystalline forms and solvate forms thereof; and compositions comprising 1-[3-(4-bromo-2-methyl-2H-pyrazol-3-yl)-4-methoxy-phenyl]-3-(2,4-difluoro-phenyl)-urea, crystalline forms and solvate forms thereof prepared by processes as described herein. |
| US10543191B2 |
Use of butylidenephthalide (Bdph), method of using the same, and method for preparing pharmaceutical composition containing the same
The present invention discloses use of butylidenephthalide (Bdph), a method of using the same, and a method for preparing a pharmaceutical composition containing the same. Because Bdph has the capability of promoting the hair growth and reducing the β-amyloid protein (Aβ) level in nerve cells, the efficacy of improving the health and appearance of a subject can be achieved by administrating an effective amount of Bdph to the subject. Specifically, the Bdph has the efficacy of preventing or treating neurodegenerative diseases such as Alzheimer's disease caused by excessive build up of Aβ in the cells, and as an active ingredient in a topical composition, the Bdph is effective in promoting the hair growth at the site where the Bdph is administered. Furthermore, the method for preparing a pharmaceutical composition containing Bdph comprises preparing the pharmaceutical composition through an organic synthesis reaction, wherein the Bdph is coated with a polymeric material such as F127 by covalent bonding of the polymeric material with the Bdph, thereby achieving the effect of reducing the cytotoxicity of the pharmaceutical composition for an organism. |