最新美国发明专利第2019-12-10期 - 专利汇|PatentHub专利检索|专利查询网|发明专利查询分析

Document	Document Title
US10503755B2	Data clustering, segmentation, and parallelization A first set of original records is processed by a first processing entity to generate a second set of records that includes the original records and one or more copies of each original record, each original record including one or more fields. The processing of each of at least some of the original records includes: generating at least one copy of the original record, and associating a first segment value with the original record and associating a second segment value with the copy. The method also includes partitioning the second set of records among a plurality of recipient processing entities based on the segment values associated with the records in the second set, and, at each recipient processing entity, performing an operation based on one or more data values of the records received at the recipient processing entity to generate results.
US10503753B2	Snapshot replication operations based on incremental block change tracking A system according to certain aspects improves the process of performing snapshot replication operations (e.g., maintaining a mirror copy of primary data at a secondary location by generating snapshots of the primary data). The system can collect and maintain cumulative block-level changes to the primary data after each sub-interval of a plurality of sub-intervals between the snapshots. When a snapshot is generated, any changes to the primary data not reflected in the cumulative block-level changes are identified based on the snapshot and transmitted to the secondary location along with the cumulative block-level changes. By the time the snapshot is generated, some or all of the changes to the primary data associated with the given snapshot have already been included in the cumulative block-level changes, thereby reducing the time and computing resources spent to identify and collect the changes for transmission to the secondary location.
US10503639B2	Cached volumes at storage gateways Methods and apparatus for supporting cached volumes at storage gateways are disclosed. A storage gateway appliance is configured to cache at least a portion of a storage object of a remote storage service at local storage devices. In response to a client's write request, directed to at least a portion of a data chunk of the storage object, the appliance stores a data modification indicated in the write request at a storage device, and asynchronously uploads the modification to the storage service. In response to a client's read request, directed to a different portion of the data chunk, the appliance downloads the requested data from the storage service to the storage device, and provides the requested data to the client.
US10503612B1	Application migration between environments A data management and storage (DMS) cluster of peer DMS nodes manages migration of an application between a primary compute infrastructure and a secondary compute infrastructure. The secondary compute infrastructure may be a failover environment for the primary compute infrastructure. Primary snapshots of virtual machines of the application in the primary compute infrastructure are generated, and provided to the secondary compute infrastructure. During a failover, the primary snapshots are deployed in the secondary compute infrastructure as virtual machines. Secondary snapshots of the virtual machines are generated, where the secondary snapshots are incremental snapshots of the primary snapshots. In failback, the secondary snapshots are provided to the primary compute infrastructure, where they are combined with the primary snapshots into construct a current state of the application, and the application is deployed in the current state by deploying virtual machines on the primary compute infrastructure.
US10503468B2	Voice enabling applications Systems and methods for voice control of computing devices are disclosed. Applications may be downloaded and/or accessed by a device having a display, and content associated with the applications may be displayed. Many applications do not allow for voice commands to be utilized to interact with the displayed content. Improvements described herein allow for non-voice-enabled applications to utilize voice commands to interact with displayed content by determining screen data displayed by the device and utilizing the screen data to determine an intent associated with the application. Directive data to perform an action corresponding to the intent may be sent to the device and may be utilized to perform the action on an object associated with the displayed content.
US10503446B2	Image forming apparatus having a folder accessible from an external apparatus, control method of image forming apparatus, and storage medium An image forming apparatus capable of communicating with an external apparatus includes a storage unit having a folder, a setting unit configured to set a printing condition corresponding to the folder, and a printing unit configured to print a printing target file transmitted from the external apparatus and stored in the folder based on the printing condition set by the setting unit.
US10503441B2	Resolving failed or hanging mount points in a clustered storage solution for containers A clustered storage system may include potentially many different nodes, each including a storage driver and a kernel module. A node may mount a virtual storage volume for the use of a container application at the node. The storage driver and kernel module may receive a request from a storage driver at a different node and respond by indicating whether the virtual storage volume is in active use. In this way, the clustered storage system may safely but forcibly unmount a virtual storage volume having a failed or hanging mount point so that the volume may be mounted on a different node.
US10503359B2	Selection attractive interfaces, systems and apparatuses including such interfaces, methods for making and using same Systems, interfaces, and methods for implementing the systems and interfaces includes selection attractive movement as the selection protocol, where a selection object is used to discriminate between selectable objects and attract a target object toward the selection objects, where the direction and speed of the motion controls, discriminates, attracts, and activates the selected objects.
US10503351B2	Managing virtual content displayed to a user based on mapped user location A technique for rendering virtual content to a user stores map data of features in a physical environment of the user and measures the location of the user with stationary sensors placed at respective locations within the environment. A server provides the location of the user and portions of the map data to a headset worn by the user. The headset is thus enabled to render virtual content at apparent locations that are based on the measured location of the user and the features described by the map data.
US10503310B2	Assistive device for non-visually discerning a three-dimensional (3D) real-world area surrounding a user An assistive device and method for non-visually discerning a three-dimensional (3D) real-world area surrounding a user, comprises a haptic feedback interface that includes a plurality of haptic elements. The assistive device receives sensor data of the 3D real-world area within a first proximity range of the assistive device from a plurality of different types of sensors that are communicatively coupled to the assistive device. The assistive device establishes a mapping of a plurality of objects within the first proximity range to the plurality of haptic elements in a defined region of the haptic feedback interface, based on the received sensor data. A haptic feedback generator generates a touch-discernible feedback on the haptic feedback interface based on the established mapping. The touch-discernible feedback comprises a plurality of differential touch-discernible cues to enable the user to non-visually discern the 3D real-world area surrounding the user.
US10503271B2	Proximity detection for an input mechanism of an electronic device Disclosed herein is an electronic device having a proximity sensor for determining whether an object, such as a user's finger, is in proximity to or in contact with an input mechanism of the electronic device.
US10503270B2	Method of training neural networks for hand pose detection A method for training a hierarchy of trained neural networks for hand pose detection includes training a first neural network to generate a first plurality of activation features that classify an input depth map data corresponding to a hand based on a wrist angle of the hand, the training using a plurality of depth maps of a hand with predetermined wrist angles as inputs to the first neural network during the training, and storing the first neural network in a memory after the training for use in classifying an additional depth map corresponding to a hand based on an angle of a wrist of the hand in the additional depth map.
US10503267B2	Systems and methods for displaying media assets associated with holographic structures Methods and systems are described for improved techniques for consuming and interacting with media content. Specifically, a media guidance application may present a holographic structure using a holographic interface. Moreover, the media guidance application may monitor the user and/or area about the holographic interface for user interactions that may cause the media guidance application to alter the holographic structure based on a user interaction. The media guidance application may also after altering the holographic structure, generate for display a media asset associated with the holographic structure.
US10503240B1	Power supply architecture for USB-C controllers A power supply architecture for USB Type-C controllers is described herein. In an example embodiment, an integrated circuit (IC) controller comprises a power rail, a VDDD terminal, a VCONN terminal, and a VBUS terminal. The VDDD terminal, the VCONN terminal, and the VBUS terminal are coupled to the power rail, where a VCONN switch is coupled between the VCONN terminal and the power rail, and a VBUS regulator is coupled between the VBUS terminal and the power rail. The power rail is coupled to internal circuits of the IC controller and is configured to provide operating power to the internal circuits from any one of the VCONN terminal and the VBUS terminal.
US10503217B1	Cable retention mechanism A retention mechanism of a dual-body computing system, including a bracket coupled to a first body of the computing system, the bracket translates along a first direction, wherein a cable assembly is attached the bracket; and springs coupled to the bracket to facilitate translating of the bracket along the first direction, wherein, as the bracket progresses from a first state to a second state based on a positioning of each body of the dual-body computing system, the first and the second springs exert an increasing force on the bracket to maintain a level of tension on the cable assembly; wherein, as the bracket progresses from the second state to the first state based on the positioning of each body of the dual-body computing system, the first and the second springs exert a decreasing force on the bracket to retract the cable within one of the bodies of the computing system.
US10503177B2	Additive delivery system with sensors An additive management system is disclosed. The system includes an additive selection system, which selects an additive for dispensing into a working fluid. The system also includes an additive dispensing system having a fluid sensing chamber with sensors. The system also includes an additive delivery system, which delivers the selected additive to the additive dispensing system, and a processor which causes the fluid sensing chamber to receive a sample of the working fluid, receives measurement signals from the one or more fluid parameter sensors corresponding with the values of fluid parameters of the working fluid, and determines values for fluid parameters of the working fluid based on the measurement signals. The processor also causes the additive delivery system to deliver the selected additive to the additive dispensing system and causes the additive dispensing system to dispense the selected additive into the working fluid through the fluid sensing chamber.
US10503076B1	Reserving spatial light modulator sections to address field non-uniformities Embodiments of the present disclosure generally provide improved photolithography systems and methods using a digital micromirror device (DMD). The DMD comprises columns and rows of micromirrors disposed opposite a substrate. Light beams reflect off the micromirrors onto the substrate, resulting in a patterned substrate. Certain subsets of the columns and rows of micromirrors may be positioned to the “off” position, such that they dump light, in order to correct for uniformity errors, i.e., features larger than desired, in the patterned substrate. Similarly, certain subsets of the columns and rows of micromirrors may be defaulted to the “off” position and selectively allowed to return to their programmed position in order to correct for uniformity errors, i.e., features smaller than desired, in the patterned substrate.
US10502848B2	Radiographic imaging apparatus A radiographic imaging apparatus includes a sensor board including a flexible substrate, and a plurality of pixels that are provided on a first surface of the substrate to accumulate electrical charges generated in accordance with light converted from radiation. Additionally, the radiographic imaging apparatus includes flexible cables having one ends electrically connected to the sensor board and the other ends provided with connectors, and flexible cables on which signal processing circuit parts are mounted and which are connected electrically to the cables by the one ends thereof being electrically connected to the connectors. Additionally, the radiographic imaging apparatus includes flexible cables having one ends electrically connected to the sensor board and the other ends provided with connectors, and flexible cables on which drive circuit parts are mounted and which are connected electrically to the cables by the one ends thereof being electrically connected to the connectors.
US10502818B2	Systems and methods for interaction with thermal detectors A system for interacting with a thermal detector includes at least one unmanned aerial vehicle and a sensor mounted to the at least one unmanned aerial vehicle. The sensor is configured to determine the presence of a component of the thermal detector and to generate a signal indicative of the presence of the component. The system also includes a beam emitter mounted to the at least one unmanned vehicle and in communication with the sensor. The beam emitter includes a beam source configured to direct a beam of thermal radiation to the thermal detector in response to the signal from the sensor.
US10502793B2	Nonlinear acoustic resonance spectroscopy (NARS) for determining physical conditions of batteries Systems and methods of determining physical conditions of a battery, such as state of charge (SOC), state of health (SOH), quality of construction, defect, or failure state include driving two or more acoustic signals of two or more amplitudes, each acoustic signal having two or more frequencies, into the battery and detecting vibrations generated in the battery based on the two or more acoustic signals. Nonlinear response characteristics of the battery for the two or more acoustic signals are determined from the detected vibrations. The physical conditions of the battery are determined based at least in part on the nonlinear response characteristics, using nonlinear acoustic resonance spectroscopy (NARS) or nonlinear resonant ultrasound spectroscopy (NRUS).
US10502737B2	Anti-thrombotic compositions and methods for assaying platelet reactivity and treatment selection Compositions and methods are provided for determining platelet reactivity where the levels of FcγRIIa on the surface of platelets is measured and if the levels of FcγRIIa are greater than a reference value, the platelets have enhanced reactivity.
US10502705B2	Resonant gas sensor A method for detecting an analyte comprises providing a first carbon-based material comprising reactive chemistry additives, providing conductive electrodes connected to the first carbon-based material, exposing the first carbon-based material to an analyte, applying a plurality of alternating currents having a range of frequencies across the conductive electrodes, and measuring the complex impedance of the first carbon-based material using the plurality of alternating currents.
US10502583B2	Method and system for dynamic estimation and predictive route generation The preferred embodiments of the present invention are directed to methods and systems for dynamic route estimation and prediction using discrete sampled location updates from various mobile devices for the purpose of providing a graphical representation of a mobile device's route along a known network path of map data. The embodiments also provide supplemental route metrics, such as traveled distance, elapsed time, etc., and the capability to assign destination points for the purpose of providing the ability to modify location update points in an application, such as a route planner, and/or to store the dynamically generated route based on various preferences for later retrieval.
US10502562B2	Measurement processing device, x-ray inspection apparatus, method for manufacturing structure, measurement processing method, x-ray inspection method, measurement processing program, and x-ray inspection program A measurement processing device used for an x-ray inspection apparatus that detects an x-ray passing through a predetermined region of a specimen placed on a placement unit to perform an inspection on the shape of the predetermined region of the specimen includes: a setting unit that sets a three-dimensional region to be detected on the specimen; and a sliced-region selection unit that sets a plurality of sliced regions on the region to be detected, calculates, for each of the plurality of sliced regions, an amount of displacement of the predetermined region that is required to detect the region to be detected when the plurality of sliced regions is regarded as the predetermined region, and selects a sliced region for the inspection from among the plurality of sliced regions on the basis of each of the calculated amounts of displacement.
US10502557B2	Method for the three dimensional measurement of a moving objects during a known movement A 3D measurement method including; projecting a pattern sequence onto a moving object; capturing a first image sequence with a first camera and a second image sequence synchronously to the first image sequence with a second camera; determining corresponding image points in the two sequences; computing a trajectory of a potential object point from imaging parameters and from known movement data for each pair of image points that is to be checked for correspondence, The potential object point is imaged by both image points in case they correspond. Imaging object positions derived therefrom at each of the capture points in time into image planes respectively of the two cameras. Corresponding image points positions are determined as trajectories in the two cameras and the image points are compared with each other along predetermined image point trajectories and examined for correspondence; lastly performing 3D measurement of the moved object by triangulation.
US10502505B2	Radiative cooling structures and systems Polymer-based selective radiative cooling structures are provided which include a selectively emissive layer of a polymer or a polymer matrix composite material. Exemplary selective radiative cooling structures are in the form of a sheet, film or coating. Also provided are methods for removing heat from a body by selective thermal radiation using polymer-based selective radiative cooling structures.
US10502377B2	Kinetic flame device An apparatus creating a flickering flame effect. The apparatus includes a housing with an interior space with first and second stages. A drive mechanism generates a time varying electromagnetic field extending into the first stage. A first pendulum member is pivotally mounted in the interior space of the first stage and includes first and second magnets on first and second ends, with the first end proximate to the drive mechanism such that the first magnet interacts with the varying electromagnetic field to cause movement of the pendulum member. The apparatus includes a second pendulum member pivotally mounted in the second stage with a magnet on a first end proximate to the second end of the first pendulum member. A flame silhouette element extends from the second pendulum member, and a light source transmits light onto the flame silhouette, which is moving due to the magnetic coupling of the pendulum members.
US10502321B2	Gasket retainer for surface mount fluid component A gasket retainer that is absent sharp corners, has apertures of reasonable dimensional tolerance, and may be conveniently made by a variety of manufacturing processes. The retainer is made from thin flat springy material that readily returns to form after slight bending. Representative gasket capturing apertures are of smoothly non-convex outline with major dimension sufficiently large to allow passage of a ring shaped gasket turned on edge and minor dimension sufficiently small to engage, on approximately opposite circular segments that each engage along less than one third of a gasket circumference, a cavity or groove on the outside diameter periphery of the gasket turned flat parallel to the retainer material sheet. Fasteners may be retained by similar apertures.
US10502283B2	Gearbox with internal diaphragm Some embodiments of a gearbox for an irrigation system can comprise a housing, a worm gear within the housing, a bull gear within the housing and configured to be engaged with the worm gear, a diaphragm, and a vent. The diaphragm can define a chamber configured for expansion and contraction and configured to be positioned inside the housing to relieve pressure build-up within the housing. The vent can be configured to allow air to flow between the atmosphere and the chamber.
US10502258B2	Tilting pad bearing assemblies; bearing apparatuses and methods of using the same Embodiments disclosed herein are directed to tilting pad bearing assemblies and bearing apparatuses using the same. As will be discussed in more detail below, the tilting pad bearing assemblies include a plurality of tilting pads. The tilting pads include at least one or more first tilting pads and one or more second tilting pads. Each of the first tilting pads includes a first superhard bearing surface having a first material. Each of the second tilting pads includes a second bearing surface having a second material. The first material includes a superhard material and the second material includes a material that is different than the first material.
US10502116B2	Frame elements for containing monoliths An element frame for holding monoliths containing catalysts in the flow of exhaust gases from a combustion source, the element frame comprising two pairs of opposing walls, wherein the walls form a rectangular or square shape, an interior formed by the walls, an inlet end, an outlet end, at least one locking element, at least one mat and at least one monolith comprising an inlet, an outlet, four sides and at least one catalyst effective in reducing the concentration of one or more gases in the exhaust gas, wherein the at least one mat and the at least one monolith being positioned in the interior of the element frame so that there is at least one mat between the monolith and each adjacent wall, each locking element extending across the inlet end or outlet end of the element frame and being connected to two opposite sides of the element frame.
US10502076B2	Inter-turbine ducts with flow control mechanisms A turbine section is provided for a gas turbine engine. The turbine section is annular about a longitudinal axis. The turbine section includes a first turbine with a first inlet and a first outlet; a second turbine with a second inlet and a second outlet; an inter-turbine duct extending from the first outlet to the second inlet and configured to direct an air flow from the first turbine to the second turbine, the inter-turbine duct being defined by a hub and a shroud; and at least a first splitter blade disposed within the inter-turbine duct. The first splitter blade includes a pressure side facing the shroud, a suction side facing the hub, and at least one vortex generating structure positioned on the suction side.
US10502042B2	Electric blender system, apparatus and method for use in fracturing underground formations using liquid petroleum gas The present invention provides a method and system for providing on-site electrical power to a fracturing operation, and an electrically powered fracturing system. Natural gas can be used to drive a turbine generator in the production of electrical power. A scalable, electrically powered fracturing fleet is provided to pump fluids for the fracturing operation, obviating the need for a constant supply of diesel fuel to the site and reducing the site footprint and infrastructure required for the fracturing operation, when compared with conventional systems. The treatment fluid can comprise a water-based fracturing fluid or a waterless liquefied petroleum gas (LPG) fracturing fluid.
US10502037B2	Tubing and annular gas lift A gas lift system may be installed within a well to allow gas lift operations where gas may be injected into the annular area of the well while producing fluids through the interior of the production tubular or upon demand may be reversed so that gas may be injected into the interior of the production tubular while producing fluids to the annular region of the well. In order to allow bidirectional production on demand two types of gas lift mandrels are installed as part of the production tubular. Both types of gas lift mandrels are configured such that gas lift valves are mounted to the exterior of the mandrels.
US10502015B2	Tubing hanger assembly with wellbore access, and method of accessing a wellbore A tubing hanger assembly for suspending a tubing string within a wellbore is provided. The tubing hanger assembly comprises a tubing head, a tubing hanger and a tubing head adapter. The tubing hanger and the tubing head adapter have aligned through-openings such that a chemical injection line and a communications line may each be passed through respective through-openings, thereby enabling an operator to have access to the wellbore. Beneficially, the assembly also comprises a bottom flange that secures the tubing head adapter to the tubing head once the tubing hanger and connected string of production tubing are landed in the wellbore. The bottom flange may be rotated so that ports in the bottom flange may be aligned with ports in an upper flange in the tubing head. A method for hanging a string of production tubing in a wellbore is also provided herein.
US10501990B2	Ladders, ladder components and related methods Ladders, ladder components and related methods are provided including various embodiments of a combination ladder. In some embodiments, a platform is provided that is fixedly coupled with a rail assembly of a combination ladder. The platform may pivot between a useable position or state and a stowed or stored position or state. The platform may maintain a position relative to certain rungs of the rail assembly while being displaceable relative to other rungs of the rail assembly. A hand rail may be coupled to the rail assembly and a tray may be coupled with the hand rail. The tray and the platform may be configured to maintain a constant distance between one another while the rail assembly is adjusted for height.
US10501960B2	Rail insert A system of fence components includes fence posts, fence rails having cavities formed in their ends, and fence rail inserts sized to be positioned within the fence rail cavities. The fence rail inserts and the fence rail cavities include corresponding mating features to allow the fence rail inserts to be positioned and locked within the fence rail cavities. The fence rail inserts also include fastener guides that allow a fastener to pass through to couple the fence rail inserts to the fence posts.
US10501944B2	Floor panel for forming a floor covering A floor panel for forming a floor covering wherein the floor panel is substantially realized on the basis of synthetic material. The floor panel is rectangular and comprises a first pair of opposite edges and a second pair of opposite edges such that both pairs of opposite edges comprise coupling parts allowing for mutually coupling a plurality of such floor panels to each other. The coupling parts of at least the first pair of opposite edges are configured such that two of such panels can be coupled to each other at these edges by means of a turning movement and the coupling parts to this aim consist of a tongue and a groove as well as locking parts, which, in the coupled condition, prevent the shifting apart of tongue and groove. The floor panel has a global thickness which is smaller than or equal to 4.5 millimeters.
US10501940B2	Heated cable cover for gutter debris preclusion devices The present invention includes a cover for use with a heat element and gutter debris preclusion devices. The cover includes a body, a front member, and a middle portion disposed between the body and the front member. The body includes a lip being operably configured to extend beyond an outer edge of the gutter when the cover is in use. The cover also includes a channel defined by the middle portion and at least the front member, wherein the channel is operably configured to receive the heat element. The cover is operably configured to hold the heat element to the gutter debris preclusion device. When the heat element is energized it will generate heat. The cover will enable the generated heat to transfer to the gutter debris preclusion device and to a gutter to which it is attached.
US10501825B2	Custom titanium alloy for 3-D printing and method of making same A Ti-6A1-4V titanium powder alloy composition having enhanced strength resulting from the addition of one or more of the following elements without requiring an increase in oxygen content: Aluminum Iron Nitrogen Carbon The composition may also be used for Ti-6A1-4V titanium alloy starting bar stock.
US10501809B2	Methods for detecting gene dysregulation by intragenic differential expression Described herein are methods, compositions and kits directed to the detection of gene dysregulations such as those arising from gene fusions and/or chromosomal abnormalities, e.g., translocations, insertions, inversions and deletions. Samples containing dysregulated gene(s) of interest may show independent expression patterns for the 5′ and 3′ regions of the gene. The methods, compositions and kits are useful for detecting mutations that cause the differential expression of a 5′ portion of a target gene relative to the 3′ region of the target gene.
US10501789B2	Microfluidic process for treating and analysing a solution containing a biological material and corresponding microfluidic circuit The subject matter of the present invention is a microfluidic process for treating and analysing a solution containing a biological material, comprising a step of introducing the solution into microchannels of a microfluidic circuit (1), a step of forming drops of this solution, under the effect of modifications of the surface tension of the solution, a step of moving the drops to one or more drop storage zones(s) (130), under the effect of modifications of the surface tension of the drops, a step of treating the drops and a step of analysing the drops.
US10501760B2	Methods for production of oxygenated terpenes The present disclosure relates to methods for producing oxygenated terpenoids, and preparation of compositions and formulations thereof. Polynucleotides, derivative enzymes, and host cells for use in such methods are also provided.
US10501740B2	Compositions and methods for inhibiting expression of factor V The invention relates to a double-stranded ribonucleic acid (dsRNA) for inhibiting the expression of Factor V, comprising an antisense strand having a nucleotide sequence which is less that 25 nucleotides in length and which is substantially complementary to at least a part of Factor V. The invention also relates to a pharmaceutical composition comprising the dsRNA together with a pharmaceutically acceptable carrier; methods for treating diseases caused by the expression of Factor V using the pharmaceutical composition; and methods for inhibiting the expression of Factor V in a cell.
US10501734B2	Compositions and methods of use thereof for making polypeptides with many instances of nonstandard amino acids Compositions, systems, and methods for preparation of polypeptides having multiple iterations of non-standard amino acids are provided. The compositions and method can be used to produce recombinant proteins at a greater yield than the same or similar polypeptides made using conventional compositions, systems, and methods. Accordingly, in some embodiments, the polypeptides are ones that could not be made using conventional methods and reagents, or could not be made a sufficient yield or purity to serve a practical purpose using conventional methods and reagents. Polypeptides made using the disclosed compositions, systems, and methods are also provided.
US10501728B2	Engineered nucleic-acid targeting nucleic acids The present disclosure provides engineered cross-type-nucleic-acid targeting nucleic acids and compositions thereof. Nucleic acid sequences encoding the engineered cross-type-nucleic-acid targeting nucleic acids, as well as expression cassettes, vectors and cells comprising such nucleic acid sequences, are described. Also, methods are disclosed for making and using the engineered cross-type-nucleic-acid targeting nucleic acids and compositions thereof.
US10501726B2	Population of isolated chicken cells reprogrammed from somatic cells The present invention relates to the production of avian induced pluripotent stem cells from non-pluripotent somatic cells, including embryonic fibroblasts and adult somatic cells. In this method, avian (including quail or chicken) somatic cells are reprogrammed into a state closely resembling embryonic stem cells including the expression of key stem cell markers alkaline phosphatase, etc. by transfecting/transducing the non-stem cells with genes (preferably using a non-integrating vector as otherwise described herein or alternatively an integrating vector, such a lentiviral vector, retroviral vector or inducible lentiviral vector, among others) which express at least nanog, Lin28 and cMyc. In preferred aspects of the invention, the transfected/transduced vectors express nanog, Lig28, cMyc, Oct 4 (POU5F1 or PouV), SOX2 and KLF4. The induced stem cells which are produced contribute to all 3 germ layers, the trophectoderm and in certain aspects, the gonad in chimeric offspring.
US10501581B2	Sequence-defined polymers and methods of making same and using same Methods of making sequence-defined polymers and sequence-defined polymers. The methods are based on the orthogonal reactivity of monomers having at least two different functional groups. The sequence-defined polymers can be used in various applications. For example, the SDPs (e.g., pH sensitive SDPs) are used in cell lysis methods or as molecular vehicles to transport drug cargo into cells.
US10501558B2	Modified Fc proteins comprising site-specific non-natural amino acid residues, conjugates of the same, methods of their preparation and methods of their use Provided herein are modified Fc proteins comprising non-natural amino acid residues at site-specific positions, conjugates of the modified Fc proteins for therapy or diagnosis, compositions comprising the modified Fc proteins and conjugates thereof, methods of their production and methods of their use. The modified Fc proteins and conjugates are useful for methods of treatment and prevention, methods of detection and methods of diagnosis.
US10501551B2	Multivalent and multispecific 41BB-binding fusion proteins This invention relates generally to molecules that specifically engage 41BB, a member of the TNF receptor superfamily (TNFRSF). More specifically, this invention relates to multivalent and multispecific molecules that bind at least 41BB.
US10501535B2	Antibody targeting stem cell factor Provided herein are methods, compositions, and uses relating to inhibitors of stem cell factor. For example, provided herein are antibodies targeting stem cell factor and methods for treating fibrotic and tissue remodeling diseases.
US10501526B2	Human antibodies to Ebola virus glycoprotein The present invention provides monoclonal antibodies, or antigen-binding fragments thereof, that bind to Ebola virus glycoproteins, pharmaceutical compositions comprising the antibodies and methods of use. The antibodies of the invention are useful for inhibiting or neutralizing Ebola virus activity, thus providing a means of treating or preventing Ebola virus infection in humans. In some embodiments, the invention provides for use of one or more antibodies that bind to the Ebola virus for preventing viral attachment and/or entry into host cells. The antibodies of the invention may be used prophylactically or therapeutically and may be used alone or in combination with one or more other anti-viral agents or vaccines.
US10501518B2	Alpha-/beta-polypeptide analogs of parathyroid hormone (PTH) and method of using same Described are polypeptide analogs of parathyroid hormone (PTH) that include at least two non-adjacent β-amino acid residues in place of a naturally occurring α-amino acid residues. Also described are pharmaceutical compositions useful for treating hypoparathyroidism that contain the analogs and methods of using the analogs to treat hypoparathyroidism.
US10501513B2	Modified polynucleotides for the production of oncology-related proteins and peptides The invention relates to compositions including polynucleotides encoding polypeptides which have been chemically modified by replacing the uridines with 1-methyl-pseudouridine to improve one or more of the stability and/or clearance in tissues, receptor uptake and/or kinetics, cellular access by the compositions, engagement with translational machinery, mRNA half-life, translation efficiency, immune evasion, protein production capacity, secretion efficiency, accessibility to circulation, protein half-life and/or modulation of a cell's status, function, and/or activity.
US10501471B1	Compounds useful for treating cardiovascular diseases The present invention provides novel compounds and pharmaceutical compositions thereof and methods of using the same for treating cardiovascular diseases.
US10501454B2	Monocyclic β-lactam-siderophore conjugate, and preparation method and use thereof The present disclosure relates to the field of pharmaceutical synthesis, and more particularly, relates to a monocyclic β-lactam-siderophore conjugate as well as a method for synthesizing same and its use in the treatment of bacterial infectious diseases. Provided are a monocyclic β-lactam-siderophore conjugate represented by formula (I) as described herein, an optical isomer thereof or a pharmaceutically acceptable salt thereof, and a method for synthesizing same, and a use thereof in treating bacterial infectious diseases.
US10501442B2	Quinoline derivative A compound represented by general formula (I) has a strong Axl inhibitory activity by introducing a distinctive bicyclic structure in which a saturated carbon ring is fused to a pyridone ring, and can be a therapeutic agent for Axl-related diseases, for example, cancer such as acute myeloid leukemia, melanoma, breast cancer, pancreatic cancer, and glioma, kidney diseases, immune system diseases, and circulatory system diseases
US10501438B2	Aryl-substituted dihydroquinolinones, their preparation and their use as pharmaceuticals This application relates to aryl-substituted dihydroquinolinones of formula (I), compositions comprising them and their uses in the treatment of diseases and conditions in which inhibition of a bromodomain is indicated. For example, the application relates to aryl-substituted dihydroquinolinones and to their use as bromodomain inhibitors. The present application is also related to the treatment or prevention of proliferative disorders, auto-immune disorders, inflammatory disorders, dermal disorders, and neoplasms, including tumors and/or cancers.
US10501422B2	Processes for the resolution of benzodiazepin-2-one and benzoazepin-2-one derivatives The present invention relates to processes and intermediates useful in the preparation of biologically active molecules, especially in the synthesis of Respiratory Syncytial Virus (RSV) inhibitors. The present invention also relates to processes and intermediates for the preparation of compounds of Formula (I-0) and Formula (I):
US10501419B2	Processes for the preparation of ivacaftor The present invention provides processes for the preparation of ivacaftor using novel intermediates and a process for its preparation.
US10501418B2	Crystalline solid forms of N-{4-[(6,7-dimethoxyquinolin-4-yl)oxy]phenyl}-N′-(4-fluorophenyl) cyclopropane-1,1-dicarboxamide, processes for making, and methods of use The invention relates to novel crystalline solid forms of the chemical compound N-{4-[(6,7-dimethoxyquinolin-4-yl)oxy]phenyl}-N′-(4-fluorophenyl) cyclopropane-1,1-dicarboxamide (Compound 1), and solvates thereof, including hydrates, that are useful for the treatment of cancer. Also disclosed are pharmaceutical compositions comprising the crystalline solid forms and processes for making the crystalline solid forms, as well as methods of using them for the treatment of cancer, particularly thyroid cancer, prostate cancer, hepatocellular cancer, renal cancer, and non-small cell lung carcinoma. The crystalline solid forms can be used to make the L-malate salt of cabozantinib.
US10501404B1	Cationic lipids and transfection methods The present invention relates in part to novel cationic lipids and their use, e.g., in delivering nucleic acids to cells.
US10501381B2	Composting device with funnel assembly The disclosure relates to a composting device including a housing defining an interior with an access opening providing access to the interior, a composter bin located within the interior and in communication with the access opening, and a funnel assembly integrated with the access opening.
US10501351B2	Composition and methods of use Provided herein are compositions and methods that can remove, metabolize, or degrade a hydrocarbon in an area that is contaminated by hydrocarbons. Methods for bioremediation of an area such as an area of land, a body of water, or a shoreline that are contaminated by a hydrocarbon, such as from a crude oil spill are also described. The compositions and methods described herein can be used on natural flora and fauna as well as manmade materials that are contaminated by a hydrocarbon.
US10501330B1	Method of preparing aluminum sulfate A method of processing a non-virgin sulfuric acid solution for the preparation of aluminum sulfate comprises the steps of combining a sulfuric acid solution having less than 90% sulfuric acid with water to form a mixed solution of no less than about 10% sulfuric acid. An alumina-containing compound such as aluminum hydroxide or aluminum bauxite is then added, the combination forming a pH of 2.0 or less. Once a specific gravity of less than about 1.36 is reached, the aluminum sulfate cools and settles overnight before filtering and/or storing.
US10501231B2	Cargo pallet having a pallet extension A cargo pallet is disclosed. The cargo pallet may have a pallet base. The cargo pallet may also have a pallet liner. The pallet liner may have a pallet liner base. The pallet liner base may be positioned on the pallet base. The pallet liner may also have a pallet extension, which may be fixedly attached to the pallet liner base. The pallet extension may project outwardly from the pallet liner base. The pallet extension may also have a support surface that may at least in part extend outwardly beyond a footprint of the pallet base.
US10501197B2	Fluidic propulsive system A propulsion system coupled to a vehicle. The system includes a convex surface, a diffusing structure coupled to the convex surface, and at least one conduit coupled to the convex surface. The conduit is configured to introduce to the convex surface a primary fluid produced by the vehicle. The system further includes an intake structure coupled to the convex surface and configured to introduce to the diffusing structure a secondary fluid accessible to the vehicle. The diffusing structure comprises a terminal end configured to provide egress from the system for the introduced primary fluid and secondary fluid.
US10501135B2	Lock mounting assemblies for transportation devices Lock mounting assemblies are disclosed for storing and mounting a locking apparatus to a transportation device. The mounting assemblies include one or more straps or connectors for securing the mounting assembly to the transportation device. The mounting assemblies having a structure to securely retain the locking apparatus on the transportation device and provide easy access to and release of the locking apparatus from the mounting assembly.
US10501055B1	Passenger and vehicle mutual authentication Some embodiments include techniques for mutual authentication between a passenger that has requested a transportation service and a dispatched vehicle for providing the requested transportation service. A user device associated with the passenger verifies the dispatched vehicle using a vehicle access token generated by a transportation service platform and sends a secret key to the dispatched vehicle. The dispatched vehicle uses the secret key to recover passenger biometric information from a passenger secret received from the user device through the transportation service platform, captures passenger biometric information on-site, and compares the recovered passenger biometric information and the passenger biometric information collected on-site to verify the passenger.
US10500988B1	Rotation assembly for a vehicle A rotation assembly for a vehicle includes a ring gear coupled to a frame of the vehicle and having serrations integrally formed therein and an inner ring that rotatably engages with the ring gear. The inner ring may directly mounted to an underside of guide tracks on a seat.
US10500785B2	Methods and apparatus for compensating for material distortion during additive manufacturing Embodiments of the present disclosure are drawn to additive manufacturing methods. An exemplary method may include generating a tool path for forming a component via additive manufacturing, and assessing the tool path to identify a change in direction. The method may also include determining if the change in direction exceeds a predetermined angle, and adding a tangent arc to the tool path before the change in direction if the change in direction exceeds the predetermined angle.
US10500739B2	Robotic surgical system Techniques for a surgical system are provided that allow an electromechanical surgical arm to be coupled at a location adjacent to a patient, such as a surgical table. A first mating element can be formed on a support member and it can be in electrical communication with a power source and a controller, and a second mating element can be formed on the electromechanical arm. The first and second mating elements can each have a respective electrical contact, and they can be configured such that mechanical coupling between the first and second mating element causes electrical communication to be established between the first and second electrical contacts and thus between the electromechanical arm and the power source and the controller. The mating elements can include tolerance elements that allow for some discrepancies between the mating elements while still providing a desired mechanical and electrical connection between the mating elements.
US10500642B2	Thermoelectric materials synthesized by self-propagating high temperature synthesis process and methods thereof The disclosure relates to thermoelectric materials prepared by self-propagating high temperature synthesis (SHS) process combining with Plasma activated sintering and methods for preparing thereof. More specifically, the present disclosure relates to the new criterion for combustion synthesis and the method for preparing the thermoelectric materials which meet the new criterion.
US10500630B2	Systems, devices, and methods for designing and forming a surgical implant A method is provided for determining the shape of a surgical linking device that is to be attached to a bony body structure such as the spinal column based on digitized locations of a plurality of attachment elements engaged to the bony structure. The method is implemented by a computer system through a GUI to generate an initial bend curve to mate with the plurality of attachment elements. The initial bend curve may be simplified based on user input to the GUI to reduce the number of bends necessary to produce a well-fitting linking device and may be altered to help obtain the goals of surgery.
US10500583B2	Systems and methods for inline, dual-stage sample dilution Sample preparation systems and methods are described having pump control, valve configurations, and control logic that facilitate automatic, inline preparation dilutions of a sample according to at least two dilution operating modes. A system embodiment includes, but is not limited to a first pump configured to drive a carrier fluid; a second pump configured to drive a diluent; and a plurality of selection valves fluidically coupled with the first pump and the second pump, the plurality of selection valves being configured to direct fluid flows from the first pump and the second pump according to at least two modes of operation to provide a single-stage sample dilution according to a first operating mode and to provide a dual-stage sample dilution according to a second operating mode.
US10500557B2	Internally reinforced aerogel and uses thereof Internally reinforced aerogels, articles of manufacture and uses thereof are described. An internally reinforced aerogel includes an aerogel having a support at least partially penetrating the aerogel and having the aerogel penetrating the porous structure of the support.
US10500529B2	Modular filter assembly A fluid filter assembly that is defined by a head portion, a base portion, and a filter tube housing that is captured therebetween. Each head portion includes more than one fluid inlet and more than one fluid outlet that are oriented relative to the respective head portion such that a plurality of fluid filter assemblies can be fluidly connected to one another to provide a desired degree of filtration of the fluid passed therethrough and such that the fluid filter assemblies can be oriented in a plurality of orientations relative to one another to provide a desired configuration of the fluid filter assembly.
US10500516B1	Burstable balloon entertainment device The invention is generally a burstable balloon entertainment device comprised of a burstable balloon filled with articles or party items such as toys, confetti, candy, and the like. The burstable balloon may be inflated using one or more hand-held pumps in fluid communication with an interior of the balloon, which are generally configured to pump air into the balloon so that the balloon eventually explodes once the inflation has reached a certain threshold. In exemplary embodiments, the burstable balloon will explode or burst once the balloon has sufficiently expanded so as to touch a balloon bursting device, which may include an extended rod having a protruding pointy or sharp tip.
US10500471B2	Impedance-based impact determination and scoring A conductive material of a plurality of separate conductive materials are coupled to a first participant, the conductive material configured to move when the first participant delivers an impact to a second participant. An impedance-based impact sensing mechanism including an impedance changing mechanism that changes impedance as the conductive material is moved towards and away from the impedance changing mechanism as the first participant delivers the impact. An impedance-based impact measuring scoring system determines that the impact occurred based on a change in impedance in the impedance changing mechanism.
US10500408B2	Method and apparatus for providing transcranial magnetic stimulation (TMS) to a patient Apparatus for applying Transcranial Magnetic Stimulation (TMS) to a patient comprising a head mount for disposition on the head of a patient, and a plurality of magnet assemblies for releasable mounting on the head mount. The magnet assemblies comprises a magnet for selectively providing a rapidly changing magnetic field capable of inducing weak electric currents for modifying the natural electrical activity of the brain of the patient. The number of magnet assemblies mounted, their individual positioning, and their selective provision of a rapidly changing magnetic field is selected to allow spatial, strength and temporal characteristics of the magnetic field to be tailored for the patient, to provide patient-specific IMS therapy, assist in diagnosis, or map out brain function. The magnet assembles can comprise magnets for provide a rapidly changing magnetic field of at least 500-600 Tesla/second corresponding to a magnet movement speed of no less than 400 Hertz.
US10500354B2	System and method for atomizing and monitoring a drug cartridge during inhalation treatments An atomizer includes a cartridge with a reservoir containing a fluid and a heating system configured to atomize the fluid into a vapor for inhalation. A respiratory indicator is configured to determine an inhalation period and an exhalation period of a patient using the atomizer. The atomizer then increases atomization of the vapor during the inhalation period and decreases atomization of the vapor during the exhalation period. An impedance sensor measures an amount of the fluid in the atomizer and deactivates atomization in response to an indication of a low fluid level.
US10500340B2	Injection system A smart injection system that promotes patient safety includes, among other things, a smart stem that allows for measuring the location of the injection relative to the patient's face and/or the amount of medication injected into the patient. In addition, the smart stem has medication cartridge verification and injector verification features. The smart stem wirelessly transmits the measure data to a processing system.
US10500310B2	Scaffold A scaffold for tissue repair or wound dressing comprising: a material layer; a polymer fibre layer; and an adhesive component between the material layer and the polymer fibre layer, wherein the adhesive component comprises material having a lower melting temperature (Tm) than the material layer and the polymer fibre layer.
US10500292B2	PSMA-binding agents and uses thereof Prostate-specific membrane antigen (PSMA) binding compounds having radioisotope substituents are described, as well as chemical precursors thereof. Compounds include pyridine containing compounds, compounds having phenylhydrazine structures, and acylated lysine compounds. The compounds allow ready incorporation of radionuclides for single photon emission computed tomography (SPECT) and positron emission tomography (PET) for imaging, for example, prostate cancer cells and angiogenesis.
US10500284B2	Pharmaceutical formulation Disclosed are aqueous pharmaceutical compositions which provide sustained released delivery of corticosteroid compounds. The pharmaceutical composition comprises a soluble corticosteroid and at least one viscosity enhancing agent. Also provided are methods for using the pharmaceutical compositions in an epidural injection, intra-articular injection, or an intra-lesional injection.
US10500274B2	Methods for reducing viral load in HIV-1 infected patients This invention provides a method of reducing viral load in an HIV-1-infected human subject which comprises administering to the subject an effective HIV-1 viral load reducing dose of a CCR5 receptor antagonist, such as a humanized antibody designated PRO 140 or an anti-CCR5 receptor monoclonal antibody, wherein the viral load reducing dose achieves an average maximum decrease of viral load in the subject of at least 1.83 log10 to 2.5 log10 at about ten days following administration of the CCR5 receptor antagonist and wherein the viral load reducing dose further achieves a mean viral load reduction of 1.7 log10 at about nine days following administration of the CCR5 receptor antagonist.
US10500266B2	Influenza virus reassortment New influenza donor strains for the production of reassortant influenza A viruses are provided.
US10500265B2	Generation of HPV-specific T-cells Embodiments of the disclosure concern methods and compositions for immunotherapy for human papillomavirus infection and diseases associated therewith. In specific embodiments, methods concern production of immune cells that target one or more antigens of HPV16 and/or HPV18, including methods with stimulation steps that employ IL-7 and IL-15, but not IL-6 and/or IL-12. Other specific embodiments utilize stimulations in the presence of certain cells, such as costimulatory cells and certain antigen presenting cells.
US10500237B2	Compositions comprising bacterial strains Provided are pharmaceutical compositions that comprise bacteria strains of the genus Roseburia for treating inflammatory and autoimmune diseases. Also provided are methods of treating inflammatory and autoimmune diseases using pharmaceutical compositions that comprise bacteria strains of the genus Roseburia. Inflammatory and autoimmune diseases for treatment with the disclosed pharmaceutical compositions can include asthma.
US10500216B2	Optimizing mifepristone absorption The present invention provides a method for altering the pharmacokinetics of mifepristone upon oral administration. Mifepristone absorption into the blood is increased upon administration with meals. The method of the invention can benefit patients suffering from conditions including psychiatric illnesses and hormonal disorders.
US10500211B2	Beta-lactamase inhibitors and uses thereof β-Lactamase inhibiting compounds, therapeutic methods of using the β-lactamase inhibiting compounds, particularly in combination with β-lactam antibiotics and pharmaceutical compositions thereof are disclosed. The β-lactamase inhibiting compounds are suitable for oral administration.
US10500192B2	Combinatorial methods to improve the therapeutic benefit of bisantrene and analogs and derivatives thereof The present invention describes methods and compositions for improving the therapeutic efficacy of therapeutic agents previously limited by suboptimal therapeutic performance by either improving efficacy as monotherapy or reducing side effects. Such methods and compositions are particularly applicable to bisantrene or derivatives, analogs, or prodrugs thereof.
US10500189B2	Composition comprising a diindolylmethane and a retinoid to treat a skin condition Provided is a composition for use in treating a skin condition, the composition comprising: (a) a first component comprising a substituted or unsubstituted diindolylmethane compound; and (b) a second component comprising a substituted or unsubstituted retinoid compound.
US10500184B2	3-methanesulfonylpropionitrile for treating inflammation and/or pain The present invention relates to purified 3-methanesulfonylpropionitrile or a pharmaceutically acceptable salt thereof, and a method for preparing such compound. The compound has at least 90% (w/w) purity. The present invention is also directed to a pharmaceutical composition comprises the purified compound and a pharmaceutically acceptable carrier. The present invention is further directed to a method for treating inflammation, inflammatory-related disorders, or pain, by administering 3-methanesulfonylpropionitrile or a pharmaceutically acceptable salt or solvate thereof to a subject in need thereof.
US10500183B2	Acetylcholinesterase inhibitors for treatment of dermatological conditions Embodiments of the invention involve treating skin afflictions by the topical or oral use of acetylcholinesterase inhibitor. By effectively reducing or eliminating the population of Demodex mites in affected skin areas and areas where Demodex mites may exist, this treatment achieves a more complete remission of clinical signs and symptoms of the skin afflictions than any previously described method. Embodiments of the invention are useful for treating skin afflictions including common acne, seborrheic dermatitis, perioral dermatitis, an acneform rash, transient acantholytic dermatosis, acne necrotica milliaris, psoriasis, steroid induced dermatitis, primary irritation dermatitis and rosacea.
US10500175B2	Compositions and methods for the treatment of cancer The present invention discloses anti-cancer compositions, and associated methods, including an anti-cancer composition comprising: a cellular energy inhibitor having the structure according to formula I wherein X is selected from the group consisting of: a nitro, an imidazole, a halide, sulfonate, a carboxylate, an alkoxide, and amine oxide; and R is selected from the group consisting of: OR′, N(R″)2, C(O)R′″, C1-C6 alkyl, C6-C12 aryl, C1-C6 heteroalkyl, a C6-C12 heteroaryl, H, and an alkali metal; where R′ represents H, alkali metal, C1-C6 alkyl, C6-C12 aryl or C(O)R′″, R″ represents H, C1-C6 alkyl, or C6-C12 aryl, and R′″ represents H, C1-C20 alkyl or C6-C12 aryl. The anti-cancer composition can additionally comprise at least one sugar, which stabilizes the cellular energy inhibitor by substantially preventing the inhibitor from hydrolyzing. Also, the anti-cancer composition can comprise a hexokinase inhibitor. Further, the anti-cancer composition can comprise a biological buffer that is present in an amount sufficient to at least partially deacidify the cellular energy inhibitor and neutralize metabolic by-products of the cellular energy inhibitor.
US10500160B2	Pharmaceutical formulation containing gelling agent Disclosed in certain embodiments is a controlled release oral dosage form comprising a therapeutically effective amount of a drug susceptible to abuse together with one or more pharmaceutically acceptable excipients; the dosage form further including a gelling agent in an effective amount to impart a viscosity unsuitable for administration selected from the group consisting of parenteral and nasal administration to a solubilized mixture formed when the dosage form is crushed and mixed with from about 0.5 to about 10 ml of an aqueous liquid; the dosage form providing a therapeutic effect for at least about 12 hours when orally administered to a human patient.
US10500118B1	Casket arrangement with handle clearance and personalization receiver A casket arrangement includes a casket base, panels extending upwardly from the casket base, and a receiver fixedly coupled to at least one of the panels. Each panel includes inwardly facing and outwardly facing surfaces. At least one of the panels includes an opening formed through the inwardly facing surface and the outwardly facing surface. A receiver or guard is fixedly coupled to the inwardly facing surface of the at least one of the panels at a portion of the inwardly facing surface that is vertically between the opening and the casket base. At least a portion of the receiver is vertically aligned with the opening and spaced apart from the inwardly facing surface.
US10500096B2	Headworn supports with passive venting and removable lens Provided herein are examples of headworn supports, such as eyewear, configured to provide passive venting by providing pathways between a lens and a frame and/or by providing a smooth anterior profile to allow a laminar flow of air on an anterior surface of the lens. The pathways through the frame and lens of the eyewear can be configured such that they do not provide a direct path to the eye of a wearer. The headworn supports provided herein can provide venting while reducing or preventing unwanted light, particles, or other debris from contacting the eye of the user. The headworn supports can also be configured to exhibit excellent ballistic performance.
US10500050B2	Device for regulating blood flow An implantable device for regulating blood flow through a blood vessel comprising an elongated support dimensioned and configured to be implanted in a blood vessel. The support includes a linking member linking axially spaced apart portions to one another. A valve membrane extends between the axially spaced apart support portions and includes first region folded over the first linking member and attached thereto and a second region adjacent the first region and unattached to the first linking member. The second region is movable between a first position to enable blood flow and a second position to inhibit blood flow.
US10500001B2	Surgical robotics system A surgical robotics system with robotic arms is configurable to perform a variety of surgical procedures. The surgical robotics system includes a table, column, base, and robotic arms that are either column-mounted, rail-mounted, or mounted on a separate unit. In a column-mounted configuration, the column includes column rings that translate vertically and rotate about the column. The robotic arms are attached to the column rings. In a rail-mounted configuration, the base includes base rails that translate along the base. The robotic arms are attached to the base rails. In both configurations, the robotic arms move independently from each other and include a multiple arm segments. Each arm segment provides an additional degree of freedom to the robotic arm. Thus, the surgical robotics system may position the robotic arms into numerous configurations to access different parts of a patient's body.
US10499956B2	Posterior stabilization systems and methods An implantable body for a posterior stabilization system includes a lateral end, a medial end, an inwardly facing surface configured to abut against a lamina when the body is implanted along a vertebra. A lateral bone outrigger extends from the inwardly facing surface and may include a bone-abutting surface along a medial portion disposed to abut against a lateral mass of the vertebra when the body is implanted along a vertebra. The lateral bone outrigger may have a first height. A penetrating feature extends from the inwardly facing surface between the bone-engaging portion of the inwardly facing surface and the lateral bone outrigger. The penetrating feature may have a second height less than the first height. A fastener bore extends through the body at an angle toward the lateral bone outrigger.
US10499919B2	Systems and methods for percutaneous access and formation of arteriovenous fistulas A catheter system includes a proximal base having a distal diagonal end surface and a distal tip connected to the proximal base and movable relative to the proximal base, wherein the distal tip has a proximal diagonal end surface. The distal diagonal end surface and the proximal diagonal end surface contact opposing sides of a tissue portion to create the fistula. A peripheral edge defines the proximal distal end surface. A proximal point is disposed on the peripheral edge. The proximal point comprises a shortened angle and a fully radiused edge relative to a remaining portion of the peripheral edge and a relief recess is disposed on a distal end of the proximal base, both for the purpose of minimizing tissue snagging.
US10499900B2	Implant devices and systems for stabilized fixation of bone and soft tissue An implant system for providing stabilized fixation of tissue includes a button having a slot, a band threaded through the slot, and a lock including a member having a slot for receiving an end of the band and a movable member for clamping the band in place. The movable member is movable between an open position and a locking position. The lock is a plug assembly which includes a flange. The slot is disposed in the flange. The movable member is a cap which is movable between clamping and non-clamping orientations relative to the flange. The plug assembly further comprises a screw for moving the cap between its clamping and non-clamping orientations relative to the flange. The flange is a portion of a plug, which plug further includes a boss extending from one side of the flange.
US10499861B2	Self-shielded, integrated-control radiosurgery system A self-shielded and computer controlled system for performing non-invasive stereotactic radiosurgery and precision radiotherapy using a linear accelerator mounted within a two degree-of-freedom radiation shield coupled to a three-degree of freedom patient table is provided. The radiation shield can include an axial shield rotatable about an axial axis and an oblique shield independently rotatable about an oblique axis, thereby providing improved range of trajectories of the therapeutic and diagnostic radiation beams. Such shields can be balanced about their respective axes of rotation and about a common support structure to facilitate ease of movement. Such systems can further include an imaging system to accurately deliver radiation to the treatment target and automatically make corrections needed to maintain the anatomical target at the system isocenter. Various subsystems to automate controlled and coordinated movement of the movable shield components and operation of the treatment related subsystems to optimize performance and ensure safety are also provided.
US10499852B2	Dental appliance for use in supporting sensing devices within an oral cavity A dental appliance is described herein. The dental appliance includes an abutment device adapted to be coupled to a jawbone and a sensor support assembly coupled to the abutment device. The sensor support assembly includes a sensor chamber that is configured to receive a sensing device therein. A chamber cover is coupled to the sensor support assembly to enclose the sensor chamber. The chamber cover includes a plurality of orifices that are configured to couple the sensor chamber in flow communication with an oral cavity. A tooth cap is coupled to the abutment device and includes a cap opening to receive the sensor support assembly therein.
US10499841B2	Analyte monitoring systems and methods A reagentless whole-blood analyte detection system that is capable of being deployed near a patient has a source capable of emitting a beam of radiation that includes a spectral band. The whole-blood system also has a detector in an optical path of the beam. The whole-blood system also has a housing that is configured to house the source and the detector. The whole-blood system also has a sample element that is situated in the optical path of the beam. The sample element has a sample cell and a sample cell wall that does not eliminate transmittance of the beam of radiation in the spectral band.
US10499803B2	Vocal cord stroboscopy A system, method, scope device, and camera control module device for a stroboscopic laryngoscope, to enable scopes able to operate with a rolling shutter-type image sensor. With selected pulsing of a strobe light, subset image data from adjacent rolling-shutter frames is selected, gain compensated for missing light and combined into a new single video frame.
US10499767B2	Cooking device and components thereof Disclosed herein is a cooking system for cooking food, the system including a housing defining a hollow chamber configured to receive a food container. The housing has an upper portion defining an opening to the hollow chamber. A lid is attachable about the upper portion of the housing and is configured to extend across the opening to the hollow chamber. At least one heating element is associated with at least one of said housing and said lid. The cooking system is operable in a plurality of modes including a pressure cooking mode and a dry cooking mode. In the pressure cooking mode, the cooking system is operable as a pressure cooker and in the dry cooking mode, the cooking system is operable as a dry cooker.
US10499766B2	Cooking device and components thereof Disclosed herein is a cooking system including a housing defining a hollow chamber. An upper portion of the housing defines an opening to the hollow chamber. A food container is receivable within said hollow chamber. A lid configured to cover the upper portion of the housing and the opening in a closed position, is moveable to an open position where the lid does not cover the opening. At least one heating element is associated with the housing or the lid. The cooking system is operable in a conductive cooking mode and a convective cooking mode. In said conductive cooking mode, the cooking system is operable as a conductive cooker and in said convective cooking mode, the cooking system is operable as a convection cooker. The cooking system is operable in the conductive cooking mode and then the convective cooking mode without removing said food container from said hollow chamber.
US10499753B1	Accessory shelf rail system An accessory shelf rail system includes a generally planar top portion, a generally planar front portion, a lower portion of the front portion angled inwardly, a rear portion of the top portion including a top channel and a lip forming a lip channel, the top channel and the lip channel are contained in an entire length of the top portion, and a step-shaped securing bracket slidably positioned in the lip channel, the step-shaped securing bracket configured to removably attach the top portion to a horizontal retail shelf.
US10499746B2	System for manufacturing string of coiled pocketed springs A system for manufacturing a string of pocketed coil springs comprising: a coil-forming subsystem that produces two coil springs; a spring transporter subsystem that receives the two coil springs at a first position and conveys the two coil springs to a second position; a spring compressor subsystem that compresses the two coil springs; a fabric-folding subsystem that receives a piece of fabric and folds the fabric to create an open side; a spring inserter subsystem that receives the two compressed coil springs and inserts the two compressed coil springs between top and bottom surfaces of a folded piece of fabric; two welder subsystems that form first and second welds between top and bottom surfaces of the folded piece of fabric, the first welds and the second welds forming a plurality of pockets in the fabric, each of the plurality of pockets comprising a compressed coil spring.
US10499744B2	Removable back rest A removable backrest is attached to a cooler in such a manner that does not interfere with the opening or closing of the lid nor does it interfere with the sealing mechanism of the cooler. The removable backrest inserts into existing slots positioned in the walls of certain commercially available coolers. The angle of the frame permits a user to sit on the complete lid of the cooler and lean against the backrest. While the backrest is in position, the lid may be opened or closed at the user's convenience.
US10499717B2	Jewelry storage and display case A jewelry storage case includes a spool having a cylindrical hollow body, a first slot at a first end, and a second slot at a second end. The first and second slots are sized and shaped to receive an end of a jewelry item that is secured to the spool. The spool may be disposed in a base and protected by a cover that is removably attached to the base.
US10499695B2	Transformable clothing A transformable article of clothing wearable by a person in a plurality of configurations. According to various embodiments, a transformable article of clothing comprises a central tubular portion coupled to a first member and a second member is configurable between a shawl and a scarf. In another embodiment, a transformable article of clothing comprises a first continuous loop coupled to a second continuous loop and is configurable among a hat, a hood, a scarf and a hand warmer. In yet another embodiment, an article of clothing comprises a mask portion and an ear muffler portion selectively retained on ears of the wearer. In still another embodiment, a transformable glove comprises a hand portion, a thumb portion, a first finger portion and a second finger portion with an opening in at least one of thumb and finger portions.
US10499683B2	Product portion enrobing process and apparatus, and resulting products A method of enrobing a product portion in polymer strands includes mounting at least one product portion on a holding device and passing the at least one product portion through a polymer enrobing zone. The polymer enrobing zone can include a flow of polymeric fibers produced by a polymer spray head. The polymer fibers can wraparound the at least one product portion to produce an enrobed product portion. The holding device can hold the at least one product portion by passing at least partially through the body of the product portion. At least a portion of the holding device is removed from the enrobed product portion. In some cases, the at least one product portion includes smokeless tobacco.
US10499682B2	Micronutrient formulation in electronic cigarettes An antioxidant formulation for use with electronic cigarettes is provided and the formulation comprises: Vitamin A, Vitamin E, Trans-Resveratrol, polyphenol, and tertiary butyl hydroquinone.
US10499649B2	Coated, antimicrobial, chemically strengthened glass and method of making The disclosure is directed to a chemically strengthened glass having antimicrobial properties and to a method of making such glass. In particular, the disclosure is directed to a chemically strengthened glass with antimicrobial properties and with a low surface energy coating on the glass that does not interfere with the antimicrobial properties of the glass. The antimicrobial has an Ag ion concentration on the surface in the range of greater than zero to 0.047 μg/cm2. The glass has particular applications as antimicrobial shelving, table tops and other applications in hospitals, laboratories and other institutions handling biological substances, where color in the glass is not a consideration.
US10499646B2	Herbicidal compositions containing N-phosphonomethyl glycine and an auxin herbicide Herbicidal compositions are provided which cause rapid symptomology while delivering long term control of regrowth of plants. The herbicidal concentrate compositions comprise N-phosphonomethylglycine or a herbicidal derivative thereof, an auxin herbicide or a herbicidal derivative thereof, and at least one surfactant. Also provided is a method for killing or controlling the growth of certain plants by contacting the foliage of the plants with the diluted concentrate composition.
US10499609B2	Vision system for teat detection A system includes a robotic arm, a laser, and a processor. The processor is configured to determine whether a first teat of a diary livestock is found in a first scan of the dairy livestock by the laser, and if so, command the robotic arm to move to a location corresponding to the location of the first teat. The processor is further configured to increment a counter associated with the first teat and then determine whether the counter equals a predetermined number. If the counter equals the predetermined number, the processor commands the robotic arm to attach a teat cup to the first teat. If the counter does not equal the predetermined number, the processor determines whether the first teat is found in a second scan by the laser. If the first teat is found in the second scan, the processor commands the robotic arm to attach the teat cup to the first teat.
US10499607B2	Vision system for teat detection A system includes a robotic arm, a laser, and a processor. The processor is configured to determine whether a distance between a left and right teat of a dairy livestock is less than or equal to a predetermined distance, and if so, command the robotic arm to move to a scan location that is between the left and right teats. The processor is further configured to command the laser to perform a scan of the teats after the robotic arm is at the scan location and to determine whether the left and right teats are found in the scan. If both the left and right teats are found in the scan, the processor commands the robotic arm to attach a teat cup to either the left or right teat.

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