Document Document Title
US10233500B2 MicroRNAs characterizing rosacea and the uses thereof
The invention relates to the identification of mircoRNAs associated with rosacea and to the uses thereof. More specifically, the invention relates to a method of diagnosing rosacea in a subject, comprising the determination, in a sample from said subject, of the expression of at least the combination of the following seven microRNAs: hsa-miR-3201, hsa-miR-4423-3p, hsa-miR-3128, hsa-miR-3163, hsa-miR-606, hsa-miR-4776-5p and hsa-miR-635.
US10233497B2 Method to detect repeat sequence motifs in nucleic acid
Methods for determining the presence or absence of expansion of CGG repeat sequence in the FMR1 gene presence or absence of expansion of CCG repeat sequence in the FMR2 gene are provided. The methods are useful in identifying an individual with normal/intermediate, versus premutation or full mutation allele of FMR1 gene and FMR2 gene due to the expansion of CGG repeats and CCG repeats in the 5′-untranslated region respectively. The methods are also useful for screening newborns for fragile X syndrome or for screening women to determine heterozygosity status with full premutation of the CCG repeat tract. The methods are also useful in estimating the premutation and full mutation carrier frequency and estimating the prevalence of FXTAS AND FXPOI in a population. The methods are simple, rapid and require small amount of sample.
US10233495B2 Methods and compositions for screening and treating developmental disorders
This document provides methods and materials related to genetic variations of developmental disorders. For example, this document provides methods for using such genetic variations to assess susceptibility of developing Autism Spectrum Disorder.
US10233494B2 High throughput screening of populations carrying naturally occurring mutations
Efficient methods are disclosed for the high throughput identification of mutations in genes in members of mutagenized populations. The methods comprise DNA isolation, pooling, amplification, creation of libraries, high throughput sequencing of libraries, preferably by sequencing-by-synthesis technologies, identification of mutations and identification of the member of the population carrying the mutation and identification of the mutation.
US10233491B2 Valved cartridge and system
This disclosure provides, among other things, a cartridge comprising: (a) a cartridge body comprising a malleable material and having, disposed on a surface of the body, at least one valve body comprising a valve inlet and a valve outlet, each fluidically connected to a fluidic channel; and (b) a layer comprising a deformable material bonded to a surface of the cartridge body and sealing the at least one valve body at points of attachment, thereby forming at least one valve; wherein the at least one valve body is depressed in the cartridge body relative to the points of attachment and wherein the deformable material covering the at least one valve body retains sufficient elasticity after deformation such that in a ground state the valve is open. Also disclosed is an instrument comprising a cartridge interface and a cartridge as described herein engaged with the cartridge interface, wherein (II) the cartridge interface comprises: (A) at least one mechanical actuator, each mechanical actuator positioned to actuate a valve; and (B) at least one motor operatively coupled to actuate a mechanical actuator toward or away from a valve.
US10233488B2 Clonal amplification of nucleic acid on solid surface with template walking
Novel methods of generating a localized population of immobilized clonal amplicons on a support are provided.
US10233487B2 Use of gel beads to control droplet dispersion
A method of generating deformable gel beads that contain a single colloidal particle is described. Gel beads containing a particle are isolated from those that do not contain a particle, based on differences between the buoyant density of these gel bead populations. The gel beads containing a particle are subsequently co-encapsulated at a high efficiency into droplets that can comprise additional objects such as cells, other particles, or reagents. The gel coating on the rigid particle prevents clogging in narrow channels, such as those of a droplet generator.
US10233485B2 Synthetic oplophorus luciferases with enhanced light output
A polynucleotide encoding a modified luciferase polypeptide. The modified luciferase polypeptide has at least 60% amino acid sequence identity to a wild-type Oplophorus luciferase and includes at least one amino acid substitution at a position corresponding to an amino acid in a wild-type Oplophorus luciferase of SEQ ID NO:1. The modified luciferase polypeptide has at least one of enhanced luminescence, enhanced signal stability, and enhanced protein stability relative to the wild-type Oplophorus luciferase.
US10233483B2 Methods of targeted antibiotic susceptibility testing
Methods are provided for performing antibiotic susceptibility testing based on the detection of RNA, such as tmRNA, from microbial cells after exposure to antibiotics. In some embodiments, aliquots are obtained from a sample, one of which contains a selected antibiotic. The aliquots, which include growth media, are incubated under conditions suitable for microbial growth, and the microbial cells in each aliquot are removed and lysed, and the lysate is subjected to reverse transcription and amplification in infer the effect of the selected antibiotic on the microbial cells. In one embodiment, a sample containing microbial cells is incubated in the presence of a selected antibiotic and a stimulus is provided to induce the production on m RNA within the microbial cells. The microbial cells are subsequently lysed without substantial degradation of the m RNA within the lysate, and the m RNA is detected to determine the effect of the antibiotic on the microbial cells.
US10233482B2 Micro-fluidic mixer and method of determining pathogen inactivation via antimicrobial solutions
A sample of produce wash water containing an antimicrobial sanitizer fluid, and a reference pathogen fluid are both injected into a pathogen inactivation region of a micro-fluidic mixer. The produce wash water (i.e. sanitizer fluid/pathogen fluid mix) is directed through mixer elements in the pathogen inactivation region of the micro-fluidic mixer. In the sanitizer deactivation region, a sanitizer deactivation solution is added to the sanitizer fluid/pathogen fluid mix to produce a deactivated solution. The deactivated solution is evaluated for the presence of the pathogen and the characteristics of the sanitizer. In the preferred embodiment, the sanitizer comprises chlorine and the pathogen comprises E. coli bacteria.
US10233480B2 Systems and methods for sample preparation using sonication
Devices, systems and methods including a sonicator for sample preparation are provided. A sonicator may be used to mix, resuspend, aerosolize, disperse, disintegrate, or de-gas a solution. A sonicator may be used to disrupt a cell, such as a pathogen cell in a sample. Sample preparation may include exposing pathogen-identifying material by sonication to detect, identify, or measure pathogens. A sonicator may transfer ultrasonic energy to the sample solution by contacting its tip to an exterior wall of a vessel containing the sample. Multipurpose devices including a sonicator also include further components for additional actions and assays. Devices, and systems comprising such devices, may communicate with a laboratory or other devices in a system for sample assay and analysis. Methods utilizing such devices and systems are provided. The improved sample preparation devices, systems and methods are useful for analyzing samples, e.g. for diagnosing patients suffering from infection by pathogens.
US10233478B2 Process for reducing CO2 emissions and increasing alcohol productivity in syngas fermentation
A process is provided that is effective for reducing CO2 emissions, enhancing STY and/or increasing cell density. The process allows for utilization of syngas from different sources by controlling concentration levels of CO, CO2 and H2 in syngas provided to the fermentation and by controlling relative concentrations of CO, CO2 and H2 in the syngas provided to the fermentation. The process includes providing syngas to a first fermentation zone and fermenting the syngas. If the first fermentation zone off-gas includes about 4 mole % or more CO, then at least a portion of the first fermentor off-gas is provided to one or more subsequent fermentation zones.
US10233476B2 Apparatus and method for analyzing a contaminated surface
An apparatus (1) for analyzing a contaminated surface has a transfer device (2) with a mount (3) and a porous disk-shaped medium (5) having a contact side (6) arrangeable on the contaminated surface. The mount (3) is bindable to the medium on its side (8) facing away from the contact side (6) via a first fixing edge (7a). An analytical device (11) is bindable to the medium (5) on its contact side (6) via a second fixing edge (7b) to remove the medium (5) from the mount (3). The first fixing edge (7a) is bindable to the medium (5) via a first adhesive bond and the second fixing edge (7b) is bindable to the medium (5) via a second adhesive bond. The first adhesive bond is breakable by a lower application of force than the second adhesive bond.
US10233472B2 Preparation of malto-oligosaccharides
Disclosed is a method for preparing a mixture of malto-oligosaccharides. Generally, a dry-milled corn fraction, such as a corn flour from which germ and fiber have been removed, is subjected to hydrolysis, typically catalyzed with acid or an enzyme such as an α-amylase enzyme, under conditions suitable to form a mixture of malto-oligosaccharides. A gluten fraction is removed and the enzyme is inactivated, such as with heat. The mixture of malto-oligosaccharides then may be recovered from remaining solids and purified.
US10233464B2 HIV pre-immunization and immunotherapy
The present invention relates generally to immunization and immunotherapy for the treatment or prevention of HIV. In particular, the methods include in vivo and/or ex vivo enrichment of HIV-specific CD4+ T cells.
US10233462B2 Methods and compositions for root knot nematode control
The present invention discloses gene targets, constructs and methods for the genetic control of plant disease caused by nematodes of the genus Meloidogyne (root knot nematodes). The present invention relates to achieving a plant protective effect through the identification of target coding sequences and the use of recombinant DNA technologies for post-transcriptionally repressing or inhibiting expression of the target coding sequences in the cells of plant-parasitic nematodes. The disclosed gene targets show significant conservation at the nucleotide level between orthologs from different Meloidogyne species, facilitating genus-wide targeting by RNA interference.
US10233459B2 Plants having altered agronomic characteristics under nitrogen limiting conditions and related constructs and methods involving low nitrogen tolerance genes
Isolated polynucleotides and polypeptides, and recombinant DNA constructs useful for conferring improved nitrogen use efficiency and/or drought stress tolerance; compositions (such as plants or seeds) comprising these recombinant DNA constructs; and methods utilizing these recombinant DNA constructs are disclosed. The recombinant DNA constructs comprise a polynucleotide operably linked to a promoter that is functional in a plant, wherein said polynucleotides encode abiotic stress tolerance polypeptides.
US10233455B2 Plant transformation without selection
The invention provides methods for identifying regenerated transformed plants and differentiated transformed plant parts, obtained without subjecting plant cells to selective conditions prior to regenerating the cells to obtain differentiated tissues. In particular embodiments, the plant cells are corn plant cells. Methods for growing and handling plants, including identifying plants that demonstrate specific traits of interest are also provided.
US10233449B2 Methods and compositions for selecting siRNA of improved functionality
Efficient sequence specific gene silencing is possible through the use of siRNA technology. By selecting particular siRNAs by rational design, one can maximize the generation of an effective gene silencing reagent, as well as methods for silencing genes. Methods, compositions, and kits generated through rational design of siRNAs are disclosed including those directed to nucleotide sequences for TTR.
US10233446B2 Micro-RNA inhibitor
The invention provides a microRNA inhibitor that has two or more sequences complementary to the sequence of microRNA to be the target of inhibition, which two or more complementary sequences are linked via one or more linker residues.
US10233445B2 Composition for delivery of genetic material
The present invention relates to exosomes, loaded with genetic material and methods of producing them and to the use of such exosomes for delivering genetic material in vivo, in particular the use of such exosomes in methods of gene therapy or gene silencing.
US10233444B2 Crude biological derivatives competent for nucleic acid detection
The invention relates to methods for the detection of a specific sequence of RNA in a cell or tissue sample. The invention also relates to methods to enzymatically manipulate the RNA in a crude cell lysate in a number of applications.
US10233443B2 Reducing adapter dimer formation
Provided herein is a method of reducing adapter dimer formation comprising contacting a sample comprising target nucleic acid sequences with 5′ and 3′ adapters in the presence of one or more hairpin oligonucleotides. Also provided is a method of preparing a library of nucleic acid sequences comprising contacting first adapter oligonucleotides with a sample comprising target nucleic acid sequences under conditions to form first ligation products, contacting the sample with one or more hairpin oligonucleotides that binds to the first adapter oligonucleotides, and contacting the sample with second adapter oligonucleotides under conditions to bind to the first ligation products and form second ligation products, wherein the second ligation products form the library of nucleic acid sequences.
US10233437B2 Hypochlorite resistant cyanuric acid hydrolases and methods of use thereof
The present invention relates to engineered cyanuric acid hydrolase enzymes that are resistant to hypochlorite and compositions and devices comprising such enzymes. The present invention also relates to methods of using these enzymes, compositions and devices for the treatment of a liquid, such as water.
US10233436B2 ADAMTS13-containing compositions having thrombolytic activity
This invention relates to a pharmaceutical composition having thrombolytic activity comprising ADAMTS13, and to methods for treating or preventing a disorder associated with the formation and/or the presence of one or more thrombus and to methods of disintegrating one or more thrombus in a patient in need thereof. Furthermore, the invention relates to the use of a pharmaceutically effective amount of ADAMTS13 for the preparation of a pharmaceutical composition for treating or preventing a disorder associated with the formation or the presence of one or more thrombus and for disintegrating one or more thrombus in a patient in need thereof.
US10233430B1 Glucose oxidase having improved thermostability
A glucose oxidase having improved thermostability is disclosed. The amino acid sequence of the glucose oxidase is a modified amino acid sequence of SEQ ID NO: 2, wherein the modification is a substitution of glutamate at position 129 with proline, and/or a substitution of glutamine at position 243 with valine.
US10233427B2 Fiber scaffolds for use in esophageal prostheses
The development and construction of implantable artificial organs, and a process for manufacturing three-dimensional polymer microscale and nanoscale structures for use as scaffolds in the growth of biological structures such as hollow organs, luminal structures, or other structures within the body are disclosed.
US10233425B2 CD137 enrichment for efficient tumor infiltrating lymphocyte selection
The invention includes compositions and methods to rapidly isolate and culture cells that are potent for use in adoptive immunotherapy. In one embodiment, the isolated cells of the invention are tumor infiltrating lymphocytes (TIL) that express CD137 (also known as 4-1BB and TNFSFR9).
US10233423B2 Method for manufacturing ciliary marginal zone-like structure
The present invention provides a method for producing a cell aggregate containing a ciliary marginal zone-like structure, including a step of culturing a cell aggregate containing a retinal tissue in which Chx10 positive cells are present in a proportion of 20% or more and 100% or less of the tissue in a serum-free medium or serum-containing medium each containing a substance acting on the Wnt signal pathway and a substance inhibiting the FGF signal pathway for only a period before the appearance of a RPE65 gene expressing cell, followed by culturing the “cell aggregate in which a RPE65 gene-expressing cell does not appear” thus obtained in a serum-free medium or serum-containing medium each free of a substance acting on the Wnt signal pathway and so on. According to the production method of the present invention, a ciliary marginal zone-like structure can be produced with high efficiency.
US10233416B2 Pressure manifold and culture module
A perfusion manifold assembly is described that allows for perfusion of a microfluidic device, such as an organ on a chip microfluidic device comprising cells that mimic cells in an organ in the body, that is detachably linked with said assembly so that fluid enters ports of the microfluidic device from a fluid reservoir, optionally without tubing, at a controllable flow rate.A culture module is contemplated that allows the perfusion and optionally mechanical actuation of one or more microfluidic devices, such as organ-on-a-chip microfluidic devices comprising cells that mimic at least one function of an organ in the body.
US10233415B1 Microfluidics cell culture device
The present disclosure provides a microfluidics device for culturing cells, such as cardiomyocytes or cardiomyocyte progenitors; and methods of culturing cells using the device. The device and culturing methods find use in drug screening methods, for methods of evaluating a drug under development, and for methods of predicting patient response to a given treatment regimen, which methods are also provided.
US10233410B2 Minimum boiling azeotrope of n-butyl-3-hydroxybutyrate and n-undecane and application of the azeotrope to solvent cleaning
A novel minimum boiling binary azeotrope of n-undecane and n-butyl-3-hydroxybutyrate is shown to have utility as a solvent for degreasing of both nonpolar and polar contaminants. The components of the azeotrope are stable against degradation and the composition is largely invariant with pressure, yielding a unique solvent that can be used in cold cleaning and in vapor degreasing at elevated temperatures and over a wide range of pressures.
US10233407B2 Liquid fabric conditioner composition and method of use
The invention includes a method of conditioning fabrics, comprising contacting fabric with a liquid composition comprising an amino-functional silicone and a quaternary ammonium, and drying said fabric at 200 degrees F. or greater. The invention includes a method of conditioning fabrics, comprising washing fabric in a detergent having a wash pH of greater than 10, contacting fabric with a liquid composition comprising an amino-functional silicone and a quaternary ammonium, and drying said fabric at less than 200 degrees F. The invention further provides a method of conditioning fabrics wherein softness, anti-static, and anti-wrinkle properties are imparted to the fabric wherein the conditioned fabric resists yellowing in industrial and institutional conditions wherein the wash pH is greater than 9 and/or the fabric temperature is 200 degrees Fahrenheit or greater.
US10233405B2 System and method for rice bran oil refinement
This application provides an oil refining system and method, including a water circulation system with a chilled water circulation unit including chilled water equipment and a chilled water pipeline, a hot water circulation unit including hot water equipment and a hot water pipeline, and an ambient temperature water circulation unit including an ambient temperature water pipeline. The oil refining system further includes a deacidification system, deodorization system, and a decoloration system to implement a systematization and automation of oil refining.
US10233398B2 Crystalline transition metal oxy-hydroxide molybdotungstate
A hydroprocessing catalyst has been developed. The catalyst is a unique crystalline transition metal oxy-hydroxide molybdotungstate material. The hydroprocessing using the crystalline ammonia transition metal oxy-hydroxide molybdotungstate material may include hydrodenitrification, hydrodesulfurization, hydrodemetallation, hydrodesilication, hydrodearomatization, hydroisomerization, hydrotreating, hydrofining, and hydrocracking.
US10233396B1 Method of producing aromatic hydrocarbons
A method of processing one or more streams in a benzene production system comprising receiving a reactor effluent stream comprising benzene from an aromatization reactor system; introducing reactor effluent stream into a first separator to produce first gas stream and first liquid stream; splitting the first gas stream into first portion and second portion of first gas stream; introducing first portion of first gas stream into a first compressor to produce first compressed gas stream; introducing first compressed gas stream into a second separator to produce recycle gas stream comprising hydrogen and second liquid stream; recycling recycle gas stream to aromatization reactor system; introducing second portion of first gas stream into a second compressor to produce second compressed gas stream; introducing second compressed gas stream into a third separator to produce gas product stream comprising hydrogen and third liquid stream; and optionally recycling gas product stream to aromatization reactor system.
US10233395B2 Process for converting mixed waste plastic (MWP) into valuable petrochemicals
A process for converting mixed waste plastic (MWP) into valuable petrochemicals including feeding MWP to a pyrolysis reactor, converting the MWP into a gaseous stream and a liquid stream, and further processing the gaseous stream into valuable petrochemicals.
US10233394B2 Integrated multi-stage solvent deasphalting and delayed coking process to produce high quality coke
Process embodiments for producing high grade coke and fuel grade coke from residual oil comprises: introducing the residual oil and a first paraffinic solvent having a carbon number Cn to a first solvent deasphalting unit to produce a high quality deasphalted oil (HQDAO) fraction and a first asphalt fraction; passing the HQDAO fraction to a delayed coker to produce green coke; passing at least a portion of the first asphalt fraction and a second paraffinic solvent carbon number of Cn+1 to a second solvent deasphalting unit to produce a low quality deasphalted oil (LQDAO) fraction and a second asphalt fraction; and passing the LQDAO fraction to the delayed coker to produce the fuel grade coke.
US10233391B2 Method and system for improving spatial efficiency of a furnace system
A furnace system includes at least one lower radiant section having a first firebox disposed therein and at least one upper radiant section disposed above the at least one lower radiant section. The at least one upper radiant section has a second firebox disposed therein. The furnace system further includes at least one convection section disposed above the at least one upper radiant section and an exhaust corridor defined by the first firebox, the second firebox, and the at least one convection section. Arrangement of the at least one upper radiant section above the at least one lower radiant section reduces an area required for construction of the furnace system.
US10233388B2 Lighting device with a first phosphor and filter particles
A lighting device includes a radiation source that emits primary radiation in the wavelength range of 300 nm to 570 nm, a first phosphor arranged in a beam path of the primary radiation source that converts at least part of the primary radiation into secondary radiation in an orange to red wavelength range of 570 nm to 800 nm, and filter particles arranged in a beam path of the secondary radiation that absorb at least part of the secondary radiation.
US10233387B2 Quantum dot article with thiol-alkene-epoxy matrix
Described is a quantum dot film article comprising a quantum dot of a cured thiol-alkene-epoxy matrix. The matrix formulations resist ingress from water and/or oxygen, while also providing acceptable color stability upon aging.
US10233385B2 Well treatment methods and fluids with GLDA salt
A well servicing fluid includes ingredients including a GLDA salt, a crosslinker, and a viscosifying agent that is not crosslinked by the crosslinker. A well treatment method includes forming a well servicing fluid with ingredients including a GLDA salt, a viscosifying agent, and a crosslinker, the GLDA salt containing a metal cation chelated with a GLDA anion. The well servicing fluid is inserted into a well in a formation. The method includes crosslinking the viscosifying agent and attaining a first viscosity of the well servicing fluid using the crosslinker. After the attaining of the first viscosity, viscosity of the well servicing fluid in the well is decreased to a second viscosity less than the first viscosity by using the GLDA anion. The GLDA salt may be a GLDA calcium salt and the crosslinker may be a zirconium crosslinker.
US10233384B2 Fracturing fluid composition and method of using same in geological formations
A composition and method required for providing a fracturing fluid pumped down a well bore and into a subterranean formation under conditions of pressure that will fracture the subterranean formation is described. More specifically, the composition increases the recovery of hydrocarbons from a geological formation penetrated by a well bore, wherein the composition includes a fracturing fluid that is liquid carbon dioxide (LCO2) with proppant to aid transport of the proppant in suspension, and thereby create a fracture using a fracturing fluid which is the thickened composition containing fumed silica. When the composition is without a proppant, the viscosity of the composition is increased in order to improve the fracturing operation through aspects such as increased fracture width and reduced fluid leak-off.
US10233380B1 Well treatment fluid having an acidic nanoparticle based dispersion and a polyamine
A well treatment fluid having an acidic nanosilica dispersion and a polyamine activator and methods of reducing water production using the well treatment fluid. The acidic nanosilica dispersion and the polyamine activator may form a gelled solid after interaction over a period.
US10233378B2 Methods and compositions for treating a subterranean formation with salt-tolerant cement slurries
Methods and compositions for treating a subterranean formation with salt-tolerant cement slurries including treating a salt-containing subterranean formation having sodium salts, potassium salts, magnesium salts, calcium salts, or any combination thereof comprising: providing a salt-tolerant cement slurry comprising: a base fluid, a cementitious material, a pozzolanic material, a salt-tolerant fluid loss additive, a salt additive, and optionally, an elastomer, a weight additive, a fluid loss intensifier, a strengthening agent, a dispersant, or any combination thereof, introducing the salt-tolerant cement slurry into the subterranean formation; and allowing the salt-tolerant cement slurry to set.
US10233376B2 Disintegratable carbon composites, methods of manufacture, and uses thereof
A carbon composite is disclosed, including a plurality of carbon grains, wherein each of the plurality of carbon grains includes a plurality of pores, and a binder disposed between the plurality of carbon grains to bond the plurality of carbon grains, wherein the binder is a disintegrable binder.
US10233367B2 Formaldehyde-free binder compositions and methods of making the binders
Formaldehyde-free binder compositions are described that include an aldehyde or ketone, an organic anhydride, an alkanol amine, and a nitrogen-containing salt of an inorganic acid. The binder compositions may be applied to fibers, such as glass fibers, to make formaldehyde-free, fiber-reinforced composites. Methods of making fiber-reinforced composites are also described, where such methods may include mixing an alkanol amine with an organic anhydride to make a first mixture, and adding a reducing sugar to the first mixture to make a second mixture. A nitrogen-containing salt may be added to the second mixture to make a binder composition, which may be applied to fibers to form a binder-fiber amalgam. The amalgam may be heated to cure the binder composition and form the fiber-reinforced composite.
US10233366B2 Hot-melt adhesive agent
The present invention provides a hot-melt adhesive agent which is capable of applying at low temperature, and has an excellent adhesiveness to a polyolefin substrate, and a disposable product obtained by employing the hot-melt adhesive agent. A hot-melt adhesive agent comprising a thermoplastic block copolymer (A) which is a copolymer of vinyl class aromatic hydrocarbons and conjugated diene compounds, wherein the thermoplastic block copolymer (A) comprises the following component (A1) and component (A2): (A1) a radial type styrene block copolymer having a styrene content of 35 to 45% by weight and a diblock content of 50 to 90% by weight, and having a viscosity at 25° C. as a 25% (by weight) toluene solution of not more than 250 mPa·s; and (A2) a styrene block copolymer having a styrene content of less than 30% by weight, and having a viscosity at 25° C. as a 25% (by weight) toluene solution of more than 250 mPa·s.
US10233363B2 Hot melt adhesive composition including a crystalline block composite
A hot melt adhesive composition includes (A) 10-95 wt % of a random or homogeneous propylene-based interpolymer having: (i) a comonomer content of at least one of C2 and C4-10 a-olefin of 7 wt % to 49 wt % based on the total weight of the propylene-based interpolymer, (ii) an MWD of 4 or less, (iii) a density of 0.90 g/cc or less, and (iv) a Brookfield viscosity of less than 50,000 centipoise, (B) 1-60 wt % of a crystalline block composite comprising: (1) a crystalline ethylene based polymer; (2) a crystalline alpha-olefin based polymer derived from at least one of a C3-10 a-olefin; and (3) a block copolymer comprising 10-90 wt % of a crystalline ethylene block comprising greater than 90 mol % units derived from ethylene and comprising 10-90 wt % of a crystalline alpha-olefin block comprising greater than 90 mol % units derived from at least one of a C3-10 a-olefin, (C) Optionally, from greater than zero to 70 wt % tackifier, and (D) Optionally, from greater than zero to 40 wt % of at least one selected from the group of a wax and an oil.
US10233362B2 Starch-containing adhesive compositions and uses thereof
The invention relates to aqueous adhesive compositions comprising a starch, in particular to starch-based adhesives for bonding paper products. Provided is an aqueous adhesive composition comprising a starch derivative and a clay, wherein said starch derivative is a highly branched starch (HBS) obtained by treatment of starch or starch derivatives with a glycogen branching enzyme (EC 2.4.1.18), and wherein the weight ratio of said HBS to said clay is within the range of from about 1:1 to 1:4.
US10233353B2 Waterborne base coat compositions and processes for preparing waterborne base coat compositions
Waterborne base coat compositions and processes for preparing base coat/clear top coat multi-layer coatings are provided. In an embodiment, a waterborne base coat composition includes water, pigment(s) and resin solids consisting of about 60 to 100 wt. % of binder solids and 0 to about 40 wt. % of crosslinker solids, the binder solids consisting of about 1 to about 40 wt. % of a urethanized polyester/(meth)acryl copolymer hybrid binder having a hydroxyl number of about 30 to about 200 mg KOH/g and a carboxyl number of about 8 to 50 mg KOH/g, and about 60 to about 99 wt. % of one or more further binders, the sum of the respective wt. % in each case equaling 100 wt. %.
US10233351B2 Hard coating composition, and hard coating film, window film and display device comprising the same
This disclosure relates to a hard coating composition, which includes a silazane compound, a thiol-based compound, a polyfunctional urethane (meth)acrylate having a cyclohexyl group, a photoinitiator, inorganic nanoparticles, and a solvent, and which can also exhibit superior scratch resistance, hardness and flexibility.
US10233349B2 Acrylic aqueous dispersions for container coatings
Acrylic aqueous dispersions useful in coating compositions for coating food and beverage containers are disclosed. The aqueous dispersion is the reaction product of: (a) a hydrophobic vinyl addition polymer containing pendant or terminal ethylenically unsaturated groups, (b) a mixture of vinyl monomers including a vinyl monomer containing carboxylic acid groups; the reaction product containing active hydrogen groups and being at least partially neutralized with a base and dispersed in aqueous medium; the aqueous dispersion being substantially free of bisphenol A and derivatives thereof.
US10233344B2 Ester-based solvent systems for printable organic light-emitting diode ink formulations
Ink compositions for forming active layers in an organic light-emitting diode are provided. Also provided are methods of forming active layers of an OLED using the ink compositions. The ink compositions comprise a solvent system in which a substantial majority of the solvent is comprised of one or more ester compounds.
US10233341B2 Ink, method of manufacturing ink, and ink cartridge
Ink includes water, a coloring material, and a copolymer including a first structure unit represented by the following Chemical formula 1 and a second structure unit including an anionic group. In the Chemical formula, R represents a hydrogen atom or a methyl group, X represents an alkylene group having 2-4 carbon atoms, and Y represents a substituted or non-substituted straight-chain alkylene group having 5 to 7 carbon atoms.
US10233340B2 Aqueous coating composition comprising a thickener preparable from at least one polyamide and at least one further polymer
The present invention relates to an aqueous coating composition comprising at least one binder (A) comprising at least one polymeric resin (A1), at least one pigment (B), and an aqueous dispersion of at least one thickener (C), where (C) is obtainable by a method comprising at least the steps (1), (2), (3), and (4), namely preparing a dispersion or solution of at least one polyurethane as a polymeric resin (C2) in at least one organic solvent (step (1)), preparing a mixture of the dispersion or solution obtained by step (1) and of a melt or solution of at least one polyamide as at least one polymeric resin (C1) having an acid number in a range from 1 to 200 mg of KOH per g of (C1) (step (2)), adding water to the mixture obtained by step (2) (step (3)), and removing the organic solvent from the mixture obtained by step (3), to give the aqueous dispersion of (C) (step (4)), to the use thereof for at least partly coating an optionally coated substrate with a basecoat film, to a coating method of this kind, and to a substrate coated accordingly.
US10233334B2 Containers, bottles, drums, vats, and tanks having a slippery surface
The present disclosure describes a strategy to create self-healing, slippery liquid-infused porous surfaces. Roughened (e.g., porous) surfaces can be utilized to lock in place a lubricating fluid, referred to herein as Liquid B to repel a wide range of materials, referred to herein as Object A (Solid A or Liquid A). Slippery liquid-infused porous surfaces outperforms other conventional surfaces in its capability to repel various simple and complex liquids (water, hydrocarbons, crude oil and blood), maintain low-contact-angle hysteresis (<2.5°), quickly restore liquid-repellency after physical damage (within 0.1-1 s), resist ice, microorganisms and insects adhesion, and function at high pressures (up to at least 690 atm). Some exemplary application where slippery liquid-infused porous surfaces will be useful include energy-efficient fluid handling and transportation, optical sensing, medicine, and as self-cleaning, and anti-fouling materials operating in extreme environments.
US10233333B2 Smudge-resistant glass articles and methods for making and using same
Described herein are coated glass or glass-ceramic articles having improved smudge resistance. Further described are methods of making and using the improved articles. The coated articles generally include a glass or glass-ceramic substrate and an oleophilic coating disposed thereon. The oleophilic coating is not a free-standing adhesive film, but a coating that is formed on or over the glass or glass-ceramic substrate.
US10233332B2 UV curable interlayer for electronic printing
UV-curable interlayer compositions are provided. In embodiments, the interlayer composition comprises at least one aliphatic di(meth)acrylate monomer diluent having a dynamic viscosity at 25° C. of less than about 100 cps; at least one (meth)acrylate oligomer selected from epoxy (meth)acrylates, polyester (meth)acrylates, polyether (meth)acrylates, urethane (meth)acrylates and combinations thereof, the at least one(meth) acrylate oligomer having a glass transition temperature in the range of from about minus 10° C. to about 100° C. and a dynamic viscosity at 25° C. of less than about 3000 cps; and at least two photoinitiators. Multilayer structures formed using the compositions and related methods are also provided.
US10233327B2 Polyarylene sulfide resin composition
A polyarylene sulfide resin composition which is excellent in mechanical strength as well as electromagnetic shielding effect, slidability and moist heat resistance.The resin composition comprises (A) 100 parts by weight of a polyarylene sulfide resin (component A) synthesized through a polymerization reaction using an aromatic disulfide-based compound as a polymerization terminator and (B) 10 to 180 parts by weight of carbon fibers (component B), wholly aromatic polyamide fibers (component C) or glass fibers (component D).
US10233326B2 Polyamide moulding compound, moulded article produced herefrom and also purposes of use
The present invention relates to a polyamide moulding compound which consists of a blend of two specific polyamides. The first polyamide is thereby based substantially on 1,5-pentanediamine as diamine component used during polycondensation. The second polyamide is thereby polyamide 6I/6T. The polyamide moulding compounds according to the invention are distinguished by extremely low shrinkage and low differential shrinkage (difference between shrinkage of the moulded article longitudinally and transversely relative to the injection flow). In addition, the present invention relates to moulded articles which are producible from the polyamide moulding compounds according to the invention and also to purposes of use of the polyamide moulding compounds.
US10233322B2 UV-curable organopolysiloxane composition, silicone gel cured product, and pressure sensor
A UV curable organopolysiloxane composition includes: (A) a linear or branched organopolysiloxane having the following formula (1): wherein R1 and R2 independently represent a monovalent hydrocarbon group, “a” is an integer of 1 to 3, and a chain line indicates a bond; (B) a linear or branched organopolysiloxane represented by the following formula (2): wherein R3 and R4 independently represent a monovalent hydrocarbon group, “a” is as defined above, and a chain line indicates a bond; and (C) a photoinitiator.
US10233320B2 Thermoplastic resin composition and resin molded article
A thermoplastic resin composition includes 18 to 44 parts by mass of a copolymer (A) and 56 to 82 parts by mass of a copolymer (B) so that the total is 100 parts by mass, and further includes 0.1 to 0.3 parts by mass of an alkaline earth metal oxide (M) with respect to 100 parts by mass of the total of the graft copolymer (A) and the copolymer (B). Graft copolymer (A) is obtained by graft copolymerization a monomer mixture (II) containing an aromatic vinyl based monomer and a vinyl cyanide based monomer in the presence of a composite rubber polymer (I). The polymer (I) is composed of a diene rubber (i) and a cross-linked acrylic acid ester polymer (ii). Copolymer (B) is obtained by polymerization of a monomer mixture containing an aromatic vinyl based monomer and a vinyl cyanide based monomer.
US10233312B2 Modified diene elastomer, synthesis method for same, and rubber composition comprising modified diene elastomer
A modified diene elastomer comprises: at least 55% by weight of entity coupled by a functional group bearing a function of formula —SiOR, in which R is a hydrogen atom or an alkyl radical, and optionally bearing another function capable of interacting with a reinforcing filler, from 5% by weight to 30% by weight of star-branched entity having three elastomeric branches connected to one and the same silicon atom belonging to a functional group bearing or not bearing a function capable of interacting with a reinforcing filler, less than or equal to 15% by weight of entity functionalized at the chain end by a functional group bearing a function —Si(OR)2, in which R is a hydrogen atom or an alkyl radical, and optionally bearing another function capable of interacting with a reinforcing filler, and a content of less than or equal to 15% by weight of non-functional diene elastomer.
US10233310B2 Polymer composition comprising a crosslinkable polyolefin with hydrolysable silane groups, catalyst and a surfactant interacting additive
The present invention relates to a polymer composition comprising a surfactant interacting additive, and wherein the polymer composition further comprises at least one silanol condensation catalyst, wherein each catalyst is selected from: i) a compound of formula I ArSO3H (I) or a precursor thereof, wherein Ar is an 1 to 4 alkyl groups substituted aryl, wherein the aryl is phenyl or naphthyl, and wherein each alkyl group, independently, is a linear or branched alkyl with 10 to 30 carbons, wherein the total number of carbons in the alkyl groups is in the range of 20 to 80 carbons; ii) a derivative of i) selected from the group consisting of an anhydride, an ester, an acetylate, an epoxy blocked ester and an amine salt thereof which is hydrolysable to the corresponding compound of formula I; and iii) a metal salt of i) wherein the metal ion is selected from the group consisting of copper, aluminum, tin and zinc; an article, for example, a coating, a wire or a cable, comprising the polymer composition, a process for producing an article and use of the polymer composition.
US10233309B2 Cellulose fiber thermoplastic composition having a cosmetic appearance and molding thereof
A inventive method to process an organic compound with a thermoplastic alloy composition comprising of a high heat hydrophilic polymer, a polyolefin, preferably with a compatibilizer that is without maleic content. A compressed pellet will be generated at low temperatures for producing a cellulose thermoplastic alloy composition improving the ability to color and replace existing compositions that are challenged by toxicity and performance. This composition can be re fractured into fine particles if necessary, to produce 3 D printed parts well beyond the degradation of the specified organic compound for cosmetic, automotive or medical markets.
US10233307B2 Dye, filler made therefrom, compositions including the filler, and method of determining degree of cure of such compositions
A compound represented by formula (I): and a treated filler having the compound on at least a portion of its surface. R is hydrogen or alkyl. X is alkylene, arylalkylene, or alkylarylene, each optionally interrupted by at least one of an ether, thioether, amine, amide, ester, thioester, carbonate, thiocarbonate, carbamate, thiocarbamate, urea, or thiourea, with alkylene optionally interrupted by arylene. W is hydroxyl, a sulfonic acid group, a phosphonic acid group, carboxylic acid group, —NHR1, epoxy, or —Si(Y)x(Z)3-x. Y is alkyl, aryl, arylalkylenyl, or alkylarylenyl. Z is halide, hydroxyl, alkoxy aryloxy, acyloxy, polyalkyleneoxy, —O— covalently bonded to the surface of the filler, or —O bonded to another silicon atom, and x is 0 or 1. A composition including the treated filler, a method of making the treated filler, and a method of determining the degree of cure of a curable polymeric resin are also disclosed.
US10233302B2 Hydrophobic aerogel materials
The present disclosure provides an aerogel composition which is durable and easy to handle, which has favorable performance in aqueous environments, and which also has favorable combustion and self-heating properties. Also provided is a method of preparing an aerogel composition which is durable and easy to handle, which has favorable performance in aqueous environments, and which has favorable combustion and self-heating properties. Further provided is a method of improving the hydrophobicity, the liquid water uptake, the heat of combustion, or the onset of thermal decomposition temperature of an aerogel composition.
US10233299B2 Polyarylene foam materials
A foam material having one glass transition temperature (Tg) and made from an immiscible composition having at least two glass transition temperatures (Tg) by an extrusion process wherein said composition (C) comprises at least one polyarylene (P1) polymer, wherein more than 50% by moles (moles %) of the recurring units of said (P1) polymer are recurring units (R1) consisting of an arylene group, wherein said arylene group is a hydrocarbon divalent group consisting of one core composed of one benzene ring or of a plurality of benzene rings fused together by sharing two or more neighboring ring carbon atoms, said benzene ring being optionally substituted, wherein each of said arylene group is bound to two other arylene groups of neighboring recurring units (R1) through a first C—C bond (E1) and a second C—C bond (E2), wherein at least 20 moles % of recurring units (R1) are kink-forming arylene units (R1-b), the remainder being rigid rod-forming arylene units (R1-a) different from aryleneR1_b units, wherein in said aryleneR1_a units the bond (E1) and the bond (E2) are co-linear and anti-parallel towards each other, said (P1) polymer being present in composition (C) in an amount of below 75% by weight (wt. %) and above 10 wt. % based on the total wt. % of (P1) polymer and (PPSU) polymer, and (ii) at least one polyphenylsulfone polymer, said (PPSU) polymer being present in composition (C) in an amount of below 90 wt. % and above 25 wt. % of based on the total wt. % of polyarylene (P4) polymer and (PPSU) polymer.
US10233296B2 Method of forming creped thin film-like structures from frothed chemistry
A method is presented for forming a collapsed foam film-like structure, the method including positioning a composition applicator adjacent to a hot non-permeable dryer surface, producing a first frothed dispersion or frothed solution from a first dispersion or solution, applying the first frothed dispersion or frothed solution to the dryer surface, allowing the first frothed dispersion or frothed solution to convert to a collapsed foam film-like structure, and scraping the collapsed foam film-like structure from the dryer surface. The method can further include producing a second dispersion or solution, blending the first dispersion or solution and the second dispersion or solution, frothing the blended dispersion or solution, applying the blended frothed dispersion or frothed solution to the dryer surface, and allowing the frothed dispersion or frothed solution to convert to a collapsed foam film-like structure.
US10233294B2 Treated liquid crystal polymer powders, paste containing the same, and liquid crystal polymer sheet including the former, stack, and method of manufacturing treated liquid crystal polymer powders
Treated liquid crystal polymer powders have been subjected to surface treatment with plasma or ultra violet rays, a paste including the treated liquid crystal polymer powders and a dispersion medium, a liquid crystal polymer sheet comprising the treated liquid crystal polymer powders or the paste including the treated liquid crystal polymer powders and a dispersion medium into a sheet, a stack including the liquid crystal polymer sheet as a resin layer, and a method of manufacturing the treated liquid crystal polymer powders are provided by the present disclosure.
US10233290B2 Bio-derived cross-linkers
A process includes utilizing biorenewable cis-3-hexenol to form a bio-derived cross-linker and utilizing the bio-derived cross-linker to form a cross-linked polymeric material.
US10233286B2 Methods for producing polyaspartic acids in the presence of methanesulfonic acid
The present invention relates to methods for producing polyaspartic acids with a weight-average molecular weight (Mw) of from 6,000 to 15,000 g/mol. The invention also relates to polyaspartic acids which can be obtained by the method according to the invention, to a composition containing the polyaspartic acids, and to the use thereof as scale inhibitors, dispersants and as an additive in dishwashing agents, detergents or cleaning agents.
US10233283B2 Polycarbonate resin for film, method for preparing the same and film including the same
A polycarbonate resin includes a repeat unit represented by Formula 1; a repeat unit represented by Formula 2; and a repeat unit represented by Formula 3, wherein the polycarbonate resin has a weight average molecular weight of about 15,000 g/mol to about 60,000 g/mol and a melt index of about 3 g/10 min to about 40 g/10 min.: wherein R1, R2, R3, R4, a, b, c, and d are the same as defined in the specification. The polycarbonate resin for film can exhibit excellent scratch resistance, elongation, chemical resistance and heat resistance, and can be used to prepare a film in roll form without any protective film.
US10233282B2 Process for making polybutylene terephthalate oligomers
A process for making oligomers of polybutylene terephthalate (PBT) with desirable intrinsic viscosity and carboxylic end group concentrations includes combining 1.4-butane diol (BDO). terephthalic acid and a catalyst to from a mixture and heating the mixture until the clearing point is reached based on visual inspection. The PBT oligomers are used in a continuous process for making polybutylene terephthalate (PBT) resin.
US10233273B2 Paraffin suppressant compositions, and methods of making and using
Disclosed herein are graphene quantum dot tagged paraffin suppressants such as graphene tagged paraffin inhibitors and paraffin dispersants and methods of making and using thereof. The graphene quantum dots are covalently bound to residues of paraffin inhibitors or dispersed with paraffin dispersants to form tagged paraffin suppressants active in inhibiting paraffin crystallization or dispersing crystalized paraffin wax in crude oils and compositions comprising crude oils. The dots can be tailored to fluoresce at wavelengths with minimized correspondence to the natural fluorescence of crude oils, enabling the measurement of the concentration of the paraffin suppressants in crude oils or compositions comprising crude oils. The tagged suppressants are used to trace the dispersion and disposition of the paraffin suppressants in oils and compositions comprising them, for example within crude-oil recovery, production, processing, or conveyance and transportation, by in situ sampling the oil or composition and measuring the fluorescence of the sampled material.
US10233272B2 Method for producing water-soluble homopolymers or copolymers which comprise (meth)acrylamide
A process for preparing water-soluble homo- or copolymers comprising (meth)acrylamide by free-radical polymerization of an aqueous solution of monoethylenically unsaturated monomers comprising at least (meth)acrylamide in the presence of at least one stabilizer for prevention of polymer degradation by molecular oxygen. The stabilizer is preferably one selected from the group of sulfur compounds, sterically hindered amines, N-oxides, nitroso compounds, aromatic hydroxyl compounds and ketones, more preferably 2-mercaptobenzothiazole or a salt thereof.
US10233268B2 Modified catalyst supports
The invention covers a supported catalyst system prepared according to a process comprising the following step: i). impregnating a silica-containing catalyst support having a specific surface area of from 150 m2/g to 800 m2/g, preferably 280 m2/g to 600 m2/g, with one or more titanium compounds of the general formula selected from RnTi(OR′)m and (RO)nTi(OR′)m, wherein R and R′ are the same or different and are selected from hydrocarbyl groups containing from 1 to 12 carbon and halogens, and wherein n is 0 to 4, m is 0 to 4 and m+n equals 4, to form a titanated silica-containing catalyst support having a Ti content of at least 0.1 wt % based on the weight of the Ti-impregnated catalyst support wherein the supported catalyst system further comprises an alumoxane and a metallocene.
US10233265B2 Modified conjugated diene polymer and method for preparing the same
Disclosed are a modified conjugated diene polymer and a method for preparing the same. The modified conjugated diene polymer and the method for preparing the same advantageously provide superior compatibility with an inorganic filler, heat generation, tensile strength and abrasion resistance, low fuel consumption and excellent resistance on wet roads.
US10233262B2 Glycan analysis
The present invention concerns methods of derivatizing sialic acids which may be present on glycan moieties. This can be of use in determining the glycosylation profiles of, for example, glycoproteins and glycolipids and the use of such methods in clinical analysis as well as biological development and control.
US10233260B2 Process for the functionalization of a surface
A functionalization is performed with a dissolved oligo- or polysaccharide derivative which contains at least one free functional group, especially an amino group, linked through a polar carbamate linkage and a spacer (X), according to the general formula I:
US10233251B2 Antibody therapeutics that bind CD137
There is disclosed compositions and methods relating to or derived from anti-CD137 antibodies. More specifically, there is disclosed fully human antibodies that bind CD137, CD137-antibody binding fragments and derivatives of such antibodies, and CD137-binding polypeptides comprising such fragments. Further still, there is disclosed nucleic acids encoding such antibodies, antibody fragments and derivatives and polypeptides, cells comprising such polynucleotides, methods of making such antibodies, antibody fragments and derivatives and polypeptides, and methods of using such antibodies, antibody fragments and derivatives and polypeptides, including methods of treating a disease requiring either stimulation of immune responses or suppression. Diseases amenable to treatment is selected from the group consisting of cancers, autoimmune diseases and viral infections.
US10233250B2 Human antibodies to the glucagon receptor and methods of use thereof for lowering blood glucose or ketone levels
The present invention provides antibodies that bind to the human glucagon receptor, designated GCGR and methods of using same. According to certain embodiments of the invention, the antibodies are fully human antibodies that bind to human GCGR. The antibodies of the invention are useful for lowering blood glucose levels and blood ketone levels and are also useful for the treatment of diseases and disorders associated with one or more GCGR biological activities, including the treatment of diabetes, diabetic ketoacidosis and long-term complications associated with diabetes, or other metabolic disorders characterized in part by elevated blood glucose levels.
US10233249B2 Antibodies and methods for treating estrogen receptor-associated diseases
Provided herein in certain embodiments are antibodies, antibody fragments, pharmaceutical compositions, methods for modulating the functions of estrogen receptor alpha 36, and methods for preventing and/or treating diseases mediated by estrogen receptor alpha 36.
US10233247B2 Method of modulating the activity of functional immune molecules
The invention relates to a method for controlling the activity of an immunologically functional molecule, such as an antibody, a protein, a peptide or the like, an agent of promoting the activity of an immunologically functional molecule, and an immunologically functional molecule having the promoted activity.
US10233245B2 Methods of treating inflammatory and autoimmune diseases with natalizumab
Natalizumab is a safe and efficacious treatment for inflammatory and autoimmune diseases, such as multiple sclerosis, Crohn's Disease, and rheumatoid arthritis. Rare occurrences of progressive multifocal leucoencephalopathy during treatment suggest the possibility that it may be related to natalizumab treatment. Monitoring for JCV and informing caregivers and patients about the manifestations of progressive multifocal leucoencephalopathy can improve the safety of natalizumab therapy.
US10233241B2 Opioid receptor binding agents and uses thereof
Agents that specifically bind to an opioid receptor in a conformationally specific way can be used to induce a conformational change in the receptor. Such agents have therapeutic applications and can be used in X-ray crystallography studies of the receptor. Such agents can also be used to improve drug discovery via compound screening and/or structure-based drug design.
US10233238B2 TNF alpha antibody or fragment thereof and methods of use
The present invention relates to anti-TNF alpha binding members and in particular to monovalent, high potency TNF alpha-binding antibody fragments being highly stable and soluble. Such binding members may be used in the treatment of inflammatory and other diseases as well as in diagnostics. Also provided are related nucleic acids, vectors, cells, and compositions.
US10233234B2 Binding moieties for biofilm remediation
Binding agents able to disrupt bacterial biofilms of diverse origin are described, including monoclonal antibodies suitable for administration to a selected species, and antibody mimics including aptamer nucleic acids. Methods to prevent formation of or to dissolve biofilms with these binding agents are also described. Immunogens for eliciting antibodies to disrupt biofilms are also described.
US10233232B2 Norovirus antibodies
The present invention relates to a binding polypeptide specifically binding to the amino acid sequence W-V-N-X1-F-Y-X2 (SEQ ID NO: 1), wherein X1 represents any amino acid, preferably Q or P, and wherein X2 represents any amino acid, preferably, T or S in a norovirus polypeptide. The present invention further relates to polynucleotide encoding a binding polypeptide of the present invention an to a host cell comprising the same or the polynucleotide of the invention. The present invention further relates to a method of detecting the presence of a norovirus capsid polypeptide in a sample and to kits, devices, and uses making use of the binding peptide of the invention.
US10233227B2 Isoform of the TGF-beta receptor II
An isoform of the TGF beta receptor II comprising a sequence of about of 80 amino acids and lacking a transmembrane domain; wherein the isoform is a TGFβ-1 agonist. The isoform comprises the amino acid sequence set forth in SEQ ID No. 12. The isoform may have the amino acid sequence set forth in SEQ ID No. 2 or sequences having at least 85% sequence identity to the sequence set forth in SEQ ID No. 2.
US10233226B2 Methods and compositions for chimeric antigen receptor targeting cancer cells
The present invention provides a chimeric antigen receptor (CAR) that recognizes B7-H3 (CD276), as well as methods of use in the treatment of diseases and disorders.
US10233224B2 Nucleic acids encoding a fusion protein useful for multi-level specific targeting of cancer cells
A compound comprising, in combination: a cell surface binding ligand or internalizing factor, such as an IL-13Rα2 binding ligand; at least one effector molecule (e.g., one, two, three or more effector molecules); optionally but preferably, a cytosol localization element covalently coupled between said binding ligand and said at least one effector molecule; and a subcellular compartment localization signal element covalently coupled between said binding ligand and said at least one effector molecule (and preferably with said cytosol localization element between said binding ligand and said subcellular compartment localization signal element). Methods of using such compounds and formulations containing the same are also described.
US10233219B2 Methods and systems for designing and/or characterizing soluble lipidated ligand agents
The present application provides methods for preparing soluble lipidated ligand agents comprising a ligand entity and a lipid entity, and in some embodiments, provides relevant parameters of each of these components, thereby enabling appropriate selection of components to assemble active agents for any given target of interest.
US10233218B2 Peptides for the specific binding of RNA targets
A recombinant polypeptide is described which comprises at least one PUF RNA-binding domain capable of specifically binding to a cytosine RNA base. The PUF RNA-binding domain of the polypeptide comprises at least one RNA base-binding motif of the general formula X1X2X3X4X5X6X7X8X9X10X11 wherein X1 is selected from the group including glutamine (Q), valine (V), methionine (M), proline (P), glutamic acid (E), and lysine (K); X2 is selected from the group including histidine (H), phenylalanine (F), tyrosine (Y), and asparagine (N); X3 is selected from the group including glycine (G) and alanine (A); X4 is selected from the group including glycine (G), alanine (A), serine (S), threonine (T) and cysteine (C); X5 is selected from the group including arginine (R), tyrosine (Y), histidine (H), and asparagine (N); X6 is selected from the group including phenylalanine (F), leucine (L), and valine (V); X7 is selected from the group including isoleucine (I), leucine (L), and valine (V); X8 is arginine (R); X9 is selected from the group including leucine (L), lysine (K), arginine (R), glutamine (Q), and histidine (H); X10 is selected from the group including lysine (K), phenylalanine (F), alanine (A), cysteine (C), isoleucine (I), valine (V), leucine (L), and methionine (M); and X11 is selected from the group including leucine (L), phenylalanine (F), isoleucine (I), and valine (V); and wherein the RNA base-binding motif is operably capable of specifically binding to a cytosine RNA base.
US10233217B2 Chimeric insecticidal proteins toxic or inhibitory to Lepidopteran pests
Nucleotide sequences are disclosed that encode novel chimeric insecticidal proteins exhibiting Lepidopteran inhibitory activity. Particular embodiments provide compositions and transformed plants, plant parts, and seeds containing the recombinant nucleic acid molecules encoding one or more of the chimeric insecticidal proteins.
US10233216B2 Compositions and methods for suppression of inhibitor formation against coagulation factors in hemophilia patients
Protein replacement therapy for patients with hemophilia or other inherited protein deficiencies is often complicated by pathogenic antibody responses, including antibodies that neutralize the therapeutic protein or that predispose to potentially life-threatening anaphylactic reactions by formation of IgE. Using murine and canine hemophilia as a model, we have developed a prophylactic protocol against such responses that is non-invasive and does not include immune suppression or genetic manipulation of the patient's cells. Oral delivery of a coagulation factor expressed in chloroplasts, bioencapsulated in plant cells, effectively blocked formation of inhibitory antibodies in protein replacement therapy. Inhibitor titers were mostly undetectable and up to 100-fold lower in treated subjects when compared to controls. Moreover, this treatment eliminated fatal anaphylactic reactions that occurred after four to six exposures to intravenous coagulation factor protein. Finally, the method can effectively be used to reverse or reduce undesirable pre-existing inhibitor titers.
US10233206B2 D-fagomine for the control of inflammatory processes related to an overactivation of the humoral immune response
The present invention belongs to the field of nutraceuticals or functional agents with immunostimulating capacity for triggering mechanisms of the innate immune response at a mucosal level. More specifically, it refers to the use of the compound D-fagomine as immunostimulating agent of the innate immune response in the mucosa and for the prevention or prophylaxis of inflammatory processes or diseases associated with an overactivation of the humoral immune response. The invention also relates to a composition comprising D-fagomine for the above referenced application.
US10233205B2 Magnetic resonance imaging contrast agent capable of detecting hydrogen peroxide and reducing reactive oxygen species
The current invention provides metal ion complexes with an organic ligand, compositions comprising such complexes. In particular, these complexes are capable of reacting with a reactive oxygen species in a subject and increase their T1-weighted relaxivities so a clinical MRI scanner can detect an oxidative stress hotspot in the subject. The disclosed complexes also exhibit excellent anti-oxidant properties and low cell toxicity, therefore can be used as a therapeutic agent to relieve oxidative stress in the subject, or as both a MRI contrast agent and therapeutic agent in a composition.
US10233199B2 Heterocyclic compound, light-emitting element, light-emitting device, electronic device, and lighting device
Provided are a heterocyclic compound which emits blue light and is represented by General Formula (G1) below, and a light-emitting element, a light-emitting device, an electronic device and a lighting device which are formed using the heterocyclic compound represented by General Formula (G1) below. The use of the heterocyclic compound represented by General Formula (G1) makes it possible to provide a light-emitting element which has high emission efficiency, and also a light-emitting device, an electronic device and a lighting device which have reduced power consumption
US10233198B2 Pro-drugs of NSAIAs with very high skin and membranes penetration rates and their new medicinal uses
The novel positively charged pro-drugs of NSAIAs in the general formulas (1, 2a, 2b, 2c, or 2d) “Structure 1, 2a, 2b, 2c, or 2d” were designed and synthesized. The compounds of the general formulas (1, 2a, 2b, 2c, or 2d) “Structure 1, 2a, 2b, 2c, or 2d” indicated above can be prepared from metal salts, organic base salts, or immobilized base salts of NSAIAs with suitable halide compounds. The positively charged amino groups in the pro-drugs in this invention largely increase the solubility of the drugs in water and will bond to the negative charge on the phosphate head group of membrane. Thus, the local concentration of the outside of the membrane or skin will be very high and will facilitate the passage of these pro-drugs from a region of high concentration to a region of low concentration. This bonding will disturb the membrane a little bit and may make some room for the lipophilic portion of the pro-drug. When the molecules of membrane move, the membrane may “crack” a little bit due to the bonding of the pro-drug. This will let the pro-drug insert into the membrane. At pH 7.4, only about 99% of the amino group is protonated. When the amino group is not protonated, the bonding between the amino group of the pro-drug and the phosphate head group of the membrane will disassociate, and the pro-drug will enter the membrane completely. When the amino group of the pro-drug flips to the other side of the membrane and thus becomes protonated, then the pro-drug is pulled into the cytosol, a semi-liquid concentrated aqueous solution or suspension. These pro-drugs can be used for treating and preventing diabetes (type I or/and type II), abnormal blood glucose and lipid levels, stroke, heart attack, and other heart and vascular diseases Alzheimer's diseases, Parkinson's diseases and other neurodegenerative diseases, psoriasis, discoid lupus erythematosus, systemic lupus erythematosus (SLE), autoimmune hepatitis, multiple sclerosis (MS), and other autoimmune diseases, amyotrophic lateral sclerosis (ALS), oculopharyngeal muscular dystrophy (OPMD), and other muscle disorders, inflamed hemorrhoids, cryptitis, other inflammatory conditions of the anorectum, and pruritus ani, prostatitis, prostatocystitis, varicose veins, autoimmune liver inflammation, autoimmune kidney inflammation, vein inflammation and other inflammations, skin cancers, breast cancer, colon-rectum cancer, oral cancer, and other cancers, scars, abnormal vascular skin lesions, birthmarks, moles (nevi), skin tags, aging spots (liver spots), and other skin disorders. These pro-drugs can be administered transdermally without the help of skin penetration enhancers.
US10233194B2 Pyrimidine compounds and pyrimido indole compounds and methods of use
The present invention discloses a compound comprising the formula: wherein R is hydrogen or an alkyl group having from one to ten carbon atoms, or a compound of the formula wherein the S is replaced by CH2, and optionally comprising a pharmaceutically acceptable salt, hydrate, or solvate thereof. A method of treating a patient having cancer or a disease comprising administering to a patient an effective amount of the compound or pharmaceutically acceptable salt, hydrate, or solvate thereof.
US10233191B2 Fused piperidine amides as modulators of ion channels
The invention relates to fused piperidine amides useful as inhibitors of ion channels for the treatment of pain. The invention also provides pharmaceutically acceptable compositions comprising the compounds of the invention and methods of using the compositions in the treatment of various disorders.
US10233190B2 IDO inhibitors
Presently provided are IDO inhibitors and pharmaceutical compositions thereof, useful for modulating an activity of indoleamine 2,3-dioxygenase; treating indoleamine 2,3-dioxygenase (IDO) mediated immunosuppression; treating a medical conditions that benefit from the inhibition of enzymatic activity of indoleamine-2,3-dioxygenase; enhancing the effectiveness of an anti-cancer treatment comprising administering an anti-cancer agent; treating tumor-specific immunosuppression associated with cancer; and treating immunosupression associated with an infectious disease.
US10233187B2 Fused bicyclic compounds for the treatment of disease
A compound having the Formula (I), or a pharmaceutically acceptable salt or solvate thereof:
US10233182B2 Substituted spirocyclic inhibitors of autotaxin
The present invention relates to compounds according to Formula I and pharmaceutically acceptable salts, synthesis, intermediates, formulations, and methods of disease treatment therewith, including cancer, lymphocyte homing, chronic inflammation, neuropathic pain, fibrotic diseases, thrombosis, and cholestatic pruritus, mediated at least in part by ATX.
US10233180B2 Substituted nitrogen-containing heterocyclic derivatives, pharmaceutical compositions comprising the same and applications of antitumor thereof
Disclosed are new substituted nitrogen-containing heterocyclic derivatives represented by formula (I) as AKT inhibitors, optical isomers, pharmaceutically acceptable salts or solvates thereof, wherein the definition of R1, R2, R3, R4, R5, R6, ring A, ring C, B, Q, Y, Z and m is shown in the description for details. In addition, medicaments comprising the derivatives as active components are also disclosed, which can be useful for treating proliferative diseases, such as cancer and inflammation, especially diseases relating to AKT kinase.
US10233175B2 Pyridinium compounds
The present invention relates to novel pyridinium compounds, their isomers, steroisomers, atropisomers, conformers, tautomers, polymorphs, hydrates and solvates. The present invention also encompasses process for preparing novel compounds and pharmaceutical composition of said compounds. The invention further relates to the use of the above mentioned compounds for the preparation of medicament for use as pharmaceuticals.
US10233168B2 14-hydroxy-docosahexaenoic acid compounds
The invention describes novel 14-hydroxy docosahexaenoic acid (DHA) analogs, their preparation, isolation, identification, purification and uses thereof.
US10233166B2 Alkylene oxide separation systems, methods, and apparatuses
A propylene oxide separation system that comprises a distillation column, a decanter, and water wash system. The distillation column is configured to receive a crude propylene oxide stream, discharge an impurity stream that comprises methanol and water, and discharge a bottoms stream that comprises a majority of the propylene oxide entering in the crude propylene oxide stream. The decanter is configured to receive at least a portion of the impurity stream and a hydrocarbon solvent to provide for formation in the decanter of an organic phase and an aqueous phase. The organic phase comprises propylene oxide and hydrocarbon solvent, and is sent to the distillation column. The aqueous phase comprises a majority weight percent of the methanol and the water entering in the impurity stream. The water wash system is configured to receive and purge the aqueous phase from the propylene oxide separation system.
US10233164B2 Acesulfame potassium compositions and processes for producing same
Compositions and processes for producing high purity acesulfame potassium are described. One process comprises the steps of forming a cyclic sulfur trioxide adduct; hydrolyzing the cyclic sulfur trioxide adduct to form an acesulfame-H composition comprising acesulfame-H; neutralizing the acesulfame-H in the acesulfame-H composition to form a crude acesulfame potassium composition comprising acesulfame potassium and less than 2800 wppm acetoacetamide-N-sulfonic acid, wherein the neutralizing step is conducted or maintained at a pH at or below 11.0; and treating the crude acesulfame potassium composition to form the finished acesulfame potassium composition comprising acesulfame potassium and less than 37 wppm acetoacetamide-N-sulfonic acid.
US10233163B2 Acesulfame potassium compositions and processes for producing same
Compositions and processes for producing high purity acesulfame potassium are described. One process comprises the steps of providing a crude acesulfame potassium composition comprising acesulfame potassium and acetoacetamide, concentrating the crude acesulfame potassium composition to form a water stream and an intermediate acesulfame potassium composition comprising acesulfame potassium and less than 33 wppm acetoacetamide, and separating the intermediate acesulfame potassium composition to form the finished acesulfame potassium composition comprising acesulfame potassium and less than 33 wppm acetoacetamide. The concentrating step is conducted at a temperature below 90° C. and the separating step is conducted at a temperature at or below 35° C.
US10233159B2 Materials for organic electroluminescent devices
The present invention relates to fluorene derivatives and to electronic devices in which these compounds are used as matrix material in the emitting layer and/or as hole-transport material and/or as electron-blocking or exciton-blocking material and/or as electron-transport material.
US10233156B2 9-membered fused ring derivative
The purpose of the present invention is to provide novel compounds having ACC2 selective inhibitory activity. In addition, the present invention provides a pharmaceutical composition comprising the compound.A compound of Formula: or its pharmaceutically acceptable salt, wherein, R1 is substituted or unsubstituted fused aromatic heterocyclyl represented by Formula: wherein, ring B is 5-membered ring, ring C is 6-membered ring; ring A is substituted or unsubstituted non-aromatic carbocycle or the like; —L1— is —O—(CR6R7)m— or the like; —L2— is —O—(CR6R7)n— or the like; each R6 is independently hydrogen or the like; each R7 is independently hydrogen or the like; each m is independently an integer of 0, 1, 2 or 3; each n is independently an integer of 1, 2 or 3; R2 is substituted or unsubstituted alkyl; R3 is hydrogen or substituted or unsubstituted alkyl; R4 is substituted or unsubstituted alkylcarbonyl or the like.
US10233155B2 Processes for the preparation of pesticide compounds
This application relates to efficient and economical synthetic chemical processes for the preparation of pesticidal thioethers. Further, the present application relates to certain novel compounds useful in the preparation of pesticidal thioethers. Specifically, this application relates to a process for the preparation of 3-chloro-1H-pyrazol-4-amine and salts thereof. More particularly, this application relates to a process for the preparation of 3-chloro-1H-pyrazol-4-amine and salts thereof by halogenating and reducing 4-nitropyrazole.
US10233153B2 Pyridinethiones, pharmaceutical compositions thereof, and their therapeutic use for treating a proliferative, inflammatory, neurodegenerative, or immune-mediated disease
Provided herein are pyridinethiones, for example, a compound of Formula I, and pharmaceutical compositions thereof. Also provided herein are methods of their use for treating, preventing, or ameliorating one or more symptoms of a proliferative, inflammatory, neurodegenerative, or immune-mediated disease (e.g., multiple sclerosis).
US10233150B2 Composition for the modulation of the activity of non-structure proteins
The present invention relates to a composition for the modulation of the activity of non-structure proteins and a compound contained therein.
US10233145B2 Zirconium- and hafnium-based metal-organic frameworks as epoxide ring-opening catalysts
Metal-organic frameworks (MOFs) and method of using the MOFs to catalyze reactions involving epoxide ring-opening mechanisms are provided. The structure of the MOFs can be represented by the formula: M6(μ3-ligand)8(OHx)8(TBAPy)2, where M is Zr or Hf, the ligands are selected from hydroxo-, oxo- and aquo-ligands, and x is independently selected from 1 or 2.
US10233143B2 Pseudoceramide compound, and external use skin preparation composition containing same
The present invention relates to a novel pseudoceramide compound, and more particularly, to a novel pseudoceramide compound represented by formula 1 and having skin moisturizing and barrier function characteristics, and a skin topical composition comprising the pseudoceramide compound: wherein R1 represents a linear C12-C18 alkyl group and has at least one double bond, and R2 represents a linear C12-C22 alkyl group and has a double bond.
US10233140B2 Process for making cyclohexanone
Disclosed are processes and systems for making cyclohexanone from a mixture comprising phenol, cyclohexanone, and cyclohexylbenzene, comprising a step of or a device for subjecting at least a portion of the mixture to hydrogenation and a step of or a device for distilling a phenol/cyclohexanone/cyclohexylbenzene mixture to obtain an effluent rich in cyclohexanone.
US10233133B2 Coated granular fertilizers, methods of manufacture thereof, and uses
A coated fertilizer comprises a fertilizer granule; and a coating disposed on a surface of the fertilizer granule, wherein the coating comprises a poly(lactic acid); a second polymer comprising a poly(butylene succinate), a cellulose triacetate, or a combination comprising at least one of the foregoing; and a sealant. Methods of making the coated fertilizer are also disclosed.
US10233132B2 Organic or organo-mineral fertilizers, method of producing thereof and production unit therefor
An apparatus for producing an organic or organo-mineral fertilizer includes —a main tank receiving water, —a reactor providing cavitation and magnetic field for activating water or for treating a biological suspension, —a mixing tank containing a preliminary shredder, —an injector receiving and saturating the suspension with air, —a fermenter receiving the obtained mixture and creating a volumetric liquid-air flow passed therethrough and fermented by biological humus. The suspension is filtered and passed into a clearing tank. At predetermined conditions, the apparatus carries out a method encompassing a preliminary treatment of water in a looped circuit by connecting the main tank with the reactor via a pump. The activated water is supplied to the mixing tank added with preliminary shredded humus. The circuit is reconnected to further treat the suspension, finally shred its particles, supply it to the fermenter, additionally mix it with humus, filter it and thereby obtain the fertilizer.
US10233131B2 Biochar
The invention provides for methods, devices, and systems for pyrolyzing biomass. A pyrolysis unit can be used for the pyrolysis of biomass to form gas, liquid, and solid products. The biomass materials can be selected such that an enhanced biochar is formed after pyrolysis. The biomass can be pyrolyzed under specified conditions such that a selected biochar core is formed. The pyrolysis process can form a stable biochar core that is inert and/or resistant to degradation. The biochar or biochar core can be functionalized to form a functionalized biochar or functionalized biochar core. Functionalization can include post-pyrolysis treatments such as supplementation with microbes or physical transformations including annealing and/or activation.
US10233125B2 Aluminium-silicon carbide composite, and power-module base plate
To provide an aluminum-silicon carbide composite which is suitable for use as a power-module base plate. An aluminum-silicon carbide composite wherein a peripheral portion having, as a main component thereof, an aluminum-ceramic fiber composite containing ceramic fibers having an average fiber diameter of at most 20 μm and an average aspect ratio of at least 100, is provided on the periphery of a flat plate-shaped aluminum-silicon carbide composite having a plate thickness of 2 to 6 mm formed by impregnating, with a metal containing aluminum, a porous silicon carbide molded body having a silicon carbide content of 50 to 80 vol %, and wherein the proportion of the aluminum-ceramic fiber composite occupied in the peripheral portion is at least 50 area %.
US10233123B2 Varistor compositions and multilayer varistor
A varistor composition free of Sb comprising: (a) ZnO; (b) B—Bi—Zn—Pr glass, or B—Bi—Zn—La glass, or a mixture thereof; (c) a cobalt compound, a chromium compound, a nickel compound, a manganese compound, or mixtures thereof; (d) SnO2; and (e) an aluminum compound, a silver compound, or a mixture thereof. By adjusting the ratio between the components, the varistor composition may be made into a multilayer varistor with inner electrodes having a low concentration of noble metals at a sintering temperature less than 1200° C. The multilayer varistor made from the varistor composition has good maximum surge current, good ESD withstand ability, and low fabrication cost.
US10233122B2 Method for producing a raw material for the production of refractory ceramic products, a raw material produced according to the method and a raw material for producing refractory ceramic products
The invention relates to a method for producing a raw material for the production of refractory ceramic products, a raw material produced by said method, and a raw material for producing refractory ceramic products.
US10233116B1 Activitation of natural pozzolans
An activated pozzolan composition includes a fine interground particulate blend of an initially unactivated natural pozzolan and a supplementary cementitious material (SCM) different than the initially unactivated natural pozzolan. The initially unactivated natural pozzolan may include volcanic ash or other natural pozzolanic deposit having a moisture content of at least 3%, and the activated pozzolan composition can have a moisture content less than 0.5% The initially unactivated natural pozzolan may have a particle size less than 1 mm before intergrinding with the SCM. The SCM used to activate the initially unactivated natural pozzolan can be initially coarse or granular with a size greater than 1-3 μm and may include granulated blast furnace slag, steel slag, other metallurgical slag, pumice, limestone, fine aggregate, shale, tuff, trass, geologic material, waste glass, glass shards, basalt, sinters, ceramics, recycled bricks, recycled concrete, refractory materials, other waste industrial products, sand, or natural mineral.
US10233114B2 Glass composition, component, and method for producing a component
A glass composition, a device and a method for producing the device are disclosed. In an embodiment, the glass composition includes a tellurium oxide in a proportion of at least 65 mol. % and at most 90 mol. %, R1O in a proportion between 0 mol. % and 20 mol. %, wherein R1 is selected from Mg, Ca, Sr, Ba, Zn, Mn and combinations thereof and at least one M12O in a proportion between 5 mol. % and 25 mol. %, wherein M1 is selected from Li, Na, K and combinations thereof. The glass component further includes at least one R22O3 in a proportion between 1 mol. % and 3 mol. %, wherein R2 is selected from Al, Ga, In, Bi, Sc, Y, La, rare earths and combinations thereof, and M2O2 in a proportion between 0 mol. % and 2 mol. %, wherein M2 is selected from Ti, Zr, Hf and combinations thereof.
US10233112B2 Laser processing of slots and holes
The present invention relates to a process for cutting and separating interior contours in thin substrates of transparent materials, in particular glass. The method involves the utilization of an ultra-short pulse laser to form perforation or holes in the substrate, that may be followed by use of a CO2 laser beam to promote full separation about the perforated line.
US10233105B2 Submerged combustion melters and methods of feeding particulate material into such melters
Methods of melting particulate feedstocks in a submerged combustion melter employing an arrangement of one or more submerged combustion burners emitting combustion products into turbulent molten material. Operating the burners such that there is established a turbulent melting region extending vertically from the floor to a splash region, the splash region extending vertically between the turbulent melting region and a head space region, the head space region extending vertically between the splash region and the melter ceiling, the ceiling positioned above the floor a height H2. Feeding the particulate feedstock into the splash region through one or more inlet ports, the inlet ports positioned at a height H1 measured from the floor, where H1/H2 ranges from about 0.33 to about 0.67. The SCM may have a baffle extending from the ceiling into the splash region. A particulate feedstock conduit may be employed, having an exit port in the splash region.
US10233099B2 Radioactive cesium decontaminator and method of producing the same, and method of removing the radioactive cesium
Disclosed herein is a radioactive cesium decontaminator, a method of producing a radioactive cesium decontaminator, and a method of removing radioactive cesium using the decontaminator. The radioactive cesium decontaminator is formed by agglomeration of primary particles. The primary particles have a magnetic particle as a core portion, a coating layer made of an organic material coating the magnetic particle, and a capturing compound made of ferrocyanide material formed on the coating layer. A cumulative diameter D50 of the decontaminator is in a range of from 2.0 μm to 50 μm, and a value of a cumulative diameter distribution (D90−D10)/D50 is less than 6. The decontaminator is made by adding a ferrocyanide aqueous solution and an aqueous solution containing at least one transition metal into a suspension liquid containing a precursor formed by magnetic particles coated with organic monomer or polymer while applying a strong shear force.
US10233098B2 Nanoporous graphene membrane for desalination of salt water
A method for the desalination of water, the method comprising flowing salt water through a free-standing single-layer membrane of nanoporous graphene having a first planar side that makes contact with the salt water and an opposing second planar side from which desalinated water exits, wherein said membrane contains nanopores having a size of up to 1 nm, along with a substantial absence of pores above 1 nm in size, wherein said nanopores up to 1 nm in size have pore edges passivated with silicon, wherein salt ions in said salt water are blocked from passing through said membrane while water in said salt water passes through said membrane to result in desalinated water exiting said membrane.
US10233095B1 Solar desalination and power generating system
The solar desalination and power generating system is a hybrid system combining a Fresnel solar concentrator with a solar desalination still, and further including at least one concentrating photovoltaic cell for simultaneously generating electrical power. The solar still includes an absorber base, at least one sidewall, and a hollow cover. The hollow cover has an inlet port for receiving seawater, which passes through an interior of the hollow cover and exits through at least one outlet port into an open interior region of the solar still. At least one collection duct collects pure water condensate. A vacuum pump selectively lowers the pressure within the open interior region of the solar still. The solar still is suspended above a linear Fresnel reflector array such that the at least one concentrating photovoltaic cell, mounted to a lower surface of the absorber base, is positioned at a focal line thereof.
US10233094B2 System and method for distillation using a condensing probe and recycled heat
A system to distill seawater is disclosed. The system includes a condensing probe that serves to increase surface area and duration that heat is transferred. The system includes a first evaporator to receive seawater and boil the received seawater and produce a water vapor in addition to a boiler that contains a refrigerant R-410A. The system includes vertical blades placed across a bottom portion of the first evaporator, allowing precipitated salt to pass between the vertical blades and settle onto a tray located underneath the bottom of the evaporator. The tray is then compartmentalized as the vertical blades rotate horizontally and create a partition separating the tray from the seawater. The system includes a glass encasing that encapsulates the boiler wherein a vacuum is disposed within the glass encasing. The system includes a heating element coupled to a circulating fan to heat water vapor in the condenser.
US10233093B2 Shuttle valve for water softener system and method
Embodiments of the invention provide a piston assembly for a control valve in a water softener system. The control valve includes a drive mechanism, one or more fluid passageways, and a seal assembly. The piston assembly includes a main piston moveably received within the seal assembly and including a first end and a second end opposite to the first end, and a shuttle piston moveably received within the seal assembly. The shuttle piston includes a first end and a second end opposite to the first end, and is configured to selectively engage the second end of the main piston to form a seal therebetween and to selectively move relative to the second end of the main piston to form an opening between the second end of the main piston and the first end of the shuttle piston, in response to movement of the main piston.
US10233090B2 Amorphous mesoporous and macroporous alumina with an optimized pore distribution, and process for its preparation
A process for the preparation of an amorphous mesoporous and macroporous alumina: at least once dissolving an acidic precursor of aluminium, adjusting pH by adding at least one basic precursor to the suspension obtained in a), co-precipitation of the suspension obtained from b) by adding at least one basic precursor and at least one acidic precursor to the suspension, filtration, drying, shaping and heat treatment.An amorphous mesoporous and macroporous alumina with bimodal pore structure: a specific surface area SBET more than 100 m2/g; a median mesopore diameter, by volume determined by mercury intrusion porosimetry, 18 nm or more; a median macropore diameter, by volume determined by mercury intrusion porosimetry, 100 to 1200 nm, limits included; a mesopore volume, as measured by mercury intrusion porosimetry, 0.7 mL/g or more; and a total pore volume, as measured by mercury porosimetry, 0.8 mL/g or more.
US10233087B2 Highly crystalline 3D graphene
Disclosed here is a composition comprising at least one graphene aerogel comprising a three-dimensional structure of graphene sheets, wherein the graphene sheets are covalently interconnected, and wherein the graphene aerogel is highly crystalline. Also described is a method for making a graphene aerogel, comprising preparing a mixture comprising a graphene oxide suspension and at least one catalyst; curing the reaction mixture to produce a wet gel; drying the wet gel to produce a dry gel; and pyrolyzing the dry gel at a temperature of 1500-3500° C. to produce the graphene aerogel.
US10233084B2 Electrochemical sensors
An electrode for use in a electrochemical sensor comprises carbon modified with a chemically sensitive redox-active compound, excluding an electrode based on carbon having derivatized thereon two redox-active species wherein at least one of said species is selected from anthraquinone, phenanthrenequinone and N,N′-diphenyl-p-phenylenediamine (DPPD). The invention further provides a pH sensor comprising: a working electrode comprising carbon modified with a chemically sensitive redox active material; and a counter electrode, wherein the ratio of the surface area of the working electrode to the surface area of the counter electrode is from 1:10 to 10:1. Also provided is a pH sensor comprising: a working electrode comprising carbon modified with a chemically sensitive redox active material, and a counter electrode, wherein the area of the working electrode is from 500 μm2 to 0.1 m2. The uses of these electrodes and sensors are also described.
US10233074B2 Structures for packaging stress-sensitive micro-electro-mechanical system stacked onto electronic circuit chip
A packaged micro-electro-mechanical system (MEMS) device (100) comprises a circuitry chip (101) attached to the pad (110) of a substrate with leads (111), and a MEMS (150) vertically attached to the chip surface by a layer (140) of low modulus silicone compound. On the chip surface, the MEMS device is surrounded by a polyimide ring (130) with a surface phobic to silicone compounds. A dome-shaped glob (160) of cured low modulus silicone material covers the MEMS and the MEMS terminal bonding wire spans (180); the glob is restricted to the chip surface area inside the polyimide ring and has a surface non-adhesive to epoxy-based molding compounds. A package (190) of polymeric molding compound encapsulates the vertical assembly of the glob embedding the MEMS, the circuitry chip, and portions of the substrate; the molding compound is non-adhering to the glob surface yet adhering to all other surfaces.
US10233073B2 Three-dimensional striped structure
A three-dimensional striped structure is provided which is formed by bonding continuous filaments in random in loops, has a longitudinal direction corresponding to an extruding direction, a lateral direction and a thickness direction perpendicular to the extruding direction, and is comprised of a polyethylene thermoplastic resin, a polyester thermoplastic elastomer or a mixture of a polyethylene thermoplastic resin and a polyethylene thermoplastic elastomer. The three dimensional striped structure has an impact resilience of not lower than 13 cm, a hysteresis loss of not higher than 34% and not lower than 13%, and a thermal expansion rate of 0 to 8% in the longitudinal direction before and after a hot-air drying test, and does not shrink during high-temperature sterilization.
US10233069B2 Hands free, controlled autofill for a dispenser
A dispensing system includes one or more digital image capture devices for capturing images in a dispenser well and a digital image analyzer operatively coupled to the digital image capture device(s) for analyzing the images for use in regulating a dispensing operation. The digital image analyzer evaluates digital images captured by the digital image capture device(s) to determine various characteristics of a container placed in the dispensing well, such as the height and position of the container.
US10233066B2 Adjustable can opener
An adjustable can opener that includes a space adjustment assembly disposed between a main body and a washer set is provided. The space adjustment assembly includes a retaining base coupled to the main body and an adjustment shifting block fitted on the retaining base. The retaining base has a stepped portion having multiple steps. The adjustment shifting block also has a stepped portion having multiple steps. Responsive to manual rotation of the adjustment shifting block, the position where one of the steps of the adjustment shifting block is in contact with a respective one of the steps of the retaining base is changed to adjust the space between a traction wheel and a cutter wheel of the can opener.
US10233065B2 Method and apparatus for maintaining the interior of a vertical structure
The present invention relates to an apparatus and a method to repair the interior of a vertical structure. The invention includes a telescopic ladder and a knockdown platform that can be deployed and assembled on-site.
US10233063B2 Filter tube installation apparatus
An apparatus for unloading and installing palletized filter tubes which includes a rack having an attachment for a roller cage assembly. The cage includes at least one roller and is positioned horizontally and outward from the rack. The filter tube is positioned through the cage and over at least one roller and fastened at the free end to the ground or other filter tubing. The apparatus is attached to a skid steer, truck bed or other movable machinery and as the machinery moves forward the palletized filter tube is pulled through the cage assembly. Retention bars may be provided to retain the palletized filter tube in place as the vehicle moves. In one iteration, the retention bars are hydraulically operated and can be opened for loading of palletized filter tube.
US10233060B2 Switching valve, switching hydraulic system and crane
The present application relates to a switching valve, a switching hydraulic system, and a crane, in which the switching valve having an oil inlet and an oil outlet comprises at least two pairs of valve oil ports, a pair of cartridge valves provided between each pair of valve oil ports, and the oil inlet and the oil outlet are controlled such that the oil inlet and the oil outlet are capable of shifting between communications with the at least two pairs of valve oil ports. The switching valve switches on and off communication between the oil inlet and the oil outlet and the at least two pairs of valve oil ports by controlling opening or closing of the cartridge valves.
US10233056B1 Grasping apparatus and methods for transporting rolling racks
A grasping apparatus for transporting one or more rolling racks. A transfer device can be used in connection with the grasping device. The grasping apparatus can include a collection area and controls. The collection area preferably extends from the transport device in a direction away from the user of the transport device. The controls are preferably located in an area accessible by a user of the transport device when using the transport device to transfer rolling racks. The collection area can include one or more extensions or armatures designed to grasp a portion of the rolling rack and secure that portion of the rolling rack for transport of that rolling rack as dictated by movement of the transfer device by the user. The controls of the grasping apparatus allow a user to removeably engage the collection area.
US10233055B1 Pneumatic vacuum elevator seal
A pneumatic vacuum elevator cylinder has a cabin inserted therein. A structural plate of the cabin has a liner attached thereto. This liner has an integral bumper formed on an external surface thereof for impact the inner surfaces of the pneumatic vacuum elevator cylinder. The bumpers have a variety of features that facilitate the smooth ride of the cabin within the elevator cylinder.
US10233051B2 Assembling reels with spring-loaded magnetic guides
A method for assembling a reel comprising a first flange, a second flange and a barrel is disclosed. This method comprises (i) securing at least one spring-loaded magnetic guide to a base; (ii) positioning the first flange over the at least one spring-loaded magnetic guide and the base, so that a distal end of the at least one spring-loaded magnetic guide is inserted through a first hole in the first flange, (iii) connecting the barrel to the first flange, (iv) connecting the second flange to the barrel so that the barrel is located between the first and second flanges, (v) inserting at least one threaded fastener through a second hole in the second flange such that a distal end of the at least one threaded fastener is magnetically attached to the distal end of the at least one spring-loaded magnetic guide, and (vi) connecting the at least one threaded fastener to the first flange to form the reel. Also disclosed are the structures of the spring loaded magnetic guide.
US10233045B2 Sheet delivery system and sheet delivery method using same
A sheet delivery system includes: a joining unit configured to join, to an intermediate section of a sheet being delivered from a delivery-side original material roll, an end section of a sheet of a standby-side original material roll; and an operation robot configured to retrieve the end section of the sheet from the standby-side original material roll and convey the end section of the sheet to the joining unit. The sheet delivery system is configured to set, in advance, a sheet retrieval position at which the sheet is retrieved from each of the original material rolls, for each of the original material rolls. The operation robot is configured to convey the end section of the sheet from each of the sheet retrieval positions to the joining unit.
US10233040B2 Sheet conveying device including dust proof cover, and image recording apparatus provided with same
A sheet conveying device includes: a housing; a sheet supply tray; and a dust proof cover including a first cover and a second cover. The sheet supply tray is supported to the housing and pivotally movable between a closed position and an open position. The first cover is supported to the housing and pivotally movable between a first position in proximity to the sheet supply tray and a second position away from the sheet supply tray. The second cover is connected to the first cover and pivotally movable about a second pivot axis between a third position in proximity to the sheet supply tray and a fourth position away from the sheet supply tray. The second cover has a center of gravity positioned closer to the housing than the second pivot axis is to the housing in a state where the sheet supply tray is in the closed position.
US10233033B2 Multiple axis work-piece tranfser apparatus
A work-piece transfer apparatus, comprising at least one work-piece engagement structure; at least one first robot arm pivotally connected to the work-piece engagement structure; a first motor coupled to the first robot arm and being adapted for translating the first robot arm fore and aft in a generally horizontal direction; a second motor; at least one second robot arm being in operating driving relationship with the second motor and operatively coupled with the work-piece engagement structure for raising and lowering the work-piece engagement structure; and a support structure for supporting the apparatus or portions thereof; wherein the first motor and second motor are operated synchronously to raise, lower, and/or translate the work-piece engagement structure in a fore and aft direction by way of one or both of the first robot arm and second robot arm.
US10233028B2 Conveyor controllers
A conveyor controller for being implemented into a conveyor system includes control circuitry and one or more network interfaces for coupling with other conveyor controllers. In one embodiment, the control circuitry configured for detecting whether a another conveyor controller is connected and to determine which network interface is used in order to set the direction of the conveyor system. In another embodiment, the control circuitry is configured, to receive configuration data from a conveyor controller connected to a network interface, and to detect if another conveyor controller is and to transmit configuration message to another conveyor controller that includes additional configuration data associated with the conveyor controller. In still another embodiment, the control circuitry transmits configuration data to a replacement conveyor controller upon getting a request from the replacement conveyor controller that has been connected to a network interface.
US10233027B1 Material handling apparatus and method
An indexing or ratcheting conveyor configured to advance loads includes a frame defining the inlet end and the outlet end of the conveyor, an indexing device with a gravity rocking pushers mounted on moving rails and pushing on the loads, the rails mounted for movement on receptacles and a powered member linked to carrying members and configured to advance the loads along a conveyance path in a direction from the inlet end to the outlet end of the conveyor. The conveyor can also include a second device configured to move the loads, disposed at the outlet end only, in a direction from the outlet end to the inlet end prior to discharge of the load outwardly from the outlet end. The conveyor can be used as a component of an oven configured to cook or bake dough in containers with electrical resistance.
US10233025B2 Idler wheel frame with frame adjustment mechanism
An idler wheel support for a conveyor belt comprises a gear rack adjustment mechanism or for use in adjusting the position of one end portion an idler wheel supporting frame. The gear rack is provided at said one end portion of the frame, such as on a foot, or on a base to which the foot is slidably coupled. A tool comprising a gear is selectively positioned for pivoting on the foot or base that does not have the gear rack with the gear engaged with the gear rack. When so engaged, pivoting the gear shifts said one end portion of the frame and adjusts the angle of the frame relative to the longitudinal conveyor frame axis and adjusts the longitudinal tracking of the conveyor belt. The gear can be mounted on a lever and positioned for pivotal engagement with the gear rack to enable adjustment of the belt tracking while the belt is moving.
US10233019B2 Replenishment and order fulfillment system
A warehousing system for storing and retrieving goods disposed in containers is provided. The system includes a multilevel storage array including an array of storage shelves for holding containers thereon, at least one substantially continuous lift for transporting containers to and from at least one level of the storage array, at least one transport vehicle located on the at least one level and configured to traverse a transport area transporting containers between the at least one continuous lift and container storage locations so that the at least one continuous lift communicates non-deterministically, via the transport vehicle, with storage locations of each of the storage shelves on the at least one level, an infeed transport system linked to the at least one continuous lift, and an order fulfillment station for generating order containers corresponding to customer orders where the order containers are entered onto the storage shelves of the storage array.
US10233017B2 Cover for container
The present invention is directed to a cover assemblies for use with containers such as large dumpsters or roll-off containers. The cover assembly generally includes a cover portion, a frame portion, and one or more mounting arms. The cover is coupled to the frame, and the frame is movable with respect to the mounting arm from a first position to a second position, wherein the first position comprises a closed position and wherein the second position comprises an open position.
US10233015B2 Container, container kit and method for assembly of container kit
The invention relates to a freight container (1), such as an air freight container, or an freight container kit comprising a base (3), a framework and panels (2) forming side walls and roof, where an elongated area along the edge of at least two of the panels (2) of the container are folded to form open profiles (5) fitting into a corresponding open profile in an adjoining panel in such a way that the open profiles form a closed hollow profile (9) when combined.The invention also relates to a method for assembling the above freight container kit, comprising the steps of; providing a base (3), arranging frame elements (4) at least around the access opening, joining and fixing the open profiles (5) of neighboring panels to each other and joining and fixing the frame elements (4) to the edges of the panels (2) lacking open profiles (5) and to the base (3).
US10233013B2 Agriculturally active product
Agriculturally active products are disclosed that are used to eliminate or otherwise control pests.
US10233010B2 Locking aerosol actuators
An aerosol actuator which may be connected to a container to form an aerosol delivery system or package wherein the aerosol actuator includes four parts: a base, a trigger, a locking ring, and an orifice cup; the locking ring including a lock stop and the trigger including a locking post to lock and unlock actuation of the aerosol actuator.
US10233009B2 Container for microwave oven and package for microwave oven
The objective is to provide a container for microwave oven and a package for microwave oven in which a clearance which is formed between a flanged portion and a lid material and a content may enter is made narrower while maintaining automatic vapor discharge function.
US10233007B2 Package, packaged product, method of releasing at least one agent into chamber portion of package, and process of packaging
A package includes a chamber portion, a hollow frame adjacent to the chamber portion, and a frangible chamber closure zone between the chamber portion and the frame. A method of releasing at least one agent into a chamber portion of a package includes rupturing a frangible closure between the chamber portion and a hollow frame to release the at least one agent contained in the hollow frame into the chamber portion. A process of packaging includes providing a base web; placing a product on the base web; positioning over the product a lid web; fixing the lid web to the base web to form a chamber portion enclosing the product; fixing the lid web to the base web to form a hollow frame adjacent to the chamber portion; and including an agent in the frame.
US10233004B2 Package
The invention relates to packaging for tobacco industry products and, particularly but not exclusively, to packages including a label having a tab. A barrier material encloses one or more tobacco industry products and has a region which, in use, forms an aperture over which is positioned the label. The tab at least partially overlies the region.
US10233002B2 Fitment for package and package for preparing a beverage from liquid supplied to the package by a device
A fitment for a package for preparing a beverage connectable to a machine for supplying sanitized liquid to the package is disclosed. The fitment includes a sealing portion and a housing and a fluid connector for fluidly connecting to the machine and to supply liquid inside the container. Also disclosed are packages containing same and methods of producing and using same.
US10232999B2 Container for providing easy access to beverage cans
A container having a multiplicity of cans therein. The container disclosed is modified from a rectangular, closed wall container to a container with part of the walls removed, thereby allowing easy access to the cans of the container. Applicant discloses a unique relationship between the walls of the opened container and the size of the beverage cans. Applicant also discloses a method for constructing a closed container that may be easily modified to remove the cans of the container.
US10232996B2 Device for reminding a user to drink from a container
Disclosed is a device for reminding a user to drink from a container. The device may be attached to either the cap of the container or may be assembled inside the cap of the container. The device includes a housing, a battery, a printed circuit board, a battery holder, a button, an upper cover, a controller for storing a reference time, a reference timeout value and generating reminding signals, at least one output unit connected to the printed circuit board to produce output signals on receiving reminding signals from the controller, a tap button placed in the indent to meet the button on receiving tap from the user. Further, the controller stores the reference time on receiving the tap from the user and generates reminding signals for the user to drink from the container when the user fails to either tap the button again or remove the button from the spout in duration of the stored reference timeout value from the reference time.
US10232995B1 Removable closure with a key code body for a fluid container
A cap for a fluid container includes a cap body including a base surface at a first end and an opening at a second end. The cap body is engageable with the fluid container. The base surface includes a first engagement structure. The cap includes a first aperture in the base surface. The cap further includes a key code body including a second engagement structure engageable with the first engagement structure. The key code body includes a key code ring. A removable closure member includes a plurality of engagement surfaces and a sealing surface disposed opposite the plurality of engagement surfaces. The removable closure member includes a sealing mechanism including a sealing member on the sealing surface. The sealing member is engageable with a portion of the base surface that defines the first aperture.
US10232990B2 Child resistant storage container
A child resistant storage container is provided. The child resistant storage container has a housing having a top half, a bottom half and a generally hollow interior storage area. A locking mechanism temporarily secures the top half of the device to the bottom half of the device. The top half has a plurality of opposing teeth that allow the top half to be separated from the bottom half only when the locking teeth of the top half are engaged with each other. The interior of the child resistant storage container may be used to store items such as medications.
US10232989B2 Spout with liquid dispensing valve
A device for filling or discharging a liquid includes an elongated body, a coaxial closure sleeve mounted axially on the main sleeve, wherein the main sleeve is slidable relative to the closure sleeve and the body and comprises an outlet end on its side remote from the body and an inlet end on the side closer to the body, facing the liquid inlet, at the inlet side the main sleeve has lateral surface outflow openings, a push-button for actuating the liquid outflow located at the outflow end of the device, located on the main sleeve at its outlet end side, which the push-button is non-rotatably mounted thereon, and between the main sleeve and the closure sleeve a sealing diaphragm, as well as the helical spring of the push-button are arranged. The liquid flows by axially displacing the push-button member.
US10232987B2 Beverage container closure
A beverage container closure or lid that is adapted for closing an open end of a beverage container. The lid is selectively couplable to the beverage container and includes a selectively openable stopper that when closed, creates a fluid-tight seal between the beverage container and the environment. The stopper may be selectively opened by a user by the user pressing a button disposed on a side of the beverage container closure. The stopper is subsequently automatically closed when the user releases the button. Thus, a user may open and close the beverage container closure using a single hand without the need to remove the beverage container closure from the beverage container.
US10232984B2 Reclosable packaging with a handle, and methods and devices for making such packaging
A reclosable pour-spout packaging, such as a bag, has a top handle and can be manufactured on a form-fill-seal machine. A reclosable structure can reversibly close and open the interior of the packaging. The handle can comprise a cut extending through the packaging. An additional seal area in the packaging can provide support so that a punch and die assembly can punch or cut the handle in the additional seal area. Additionally or alternatively, a laser device, a blade, a knife, or another cutting tool can form the handle in the additional seal area. The additional sealed area can provide stiffness for carrying the packaging and also prevent access into the packaging where the handle is made. The additional seal area can be positioned below the top seal of the packaging so that less material is used for the handle.
US10232980B1 Modular cylindrical storage systems and methods
A storage system has a primary container assembly and a secondary container assembly. The primary container assembly has a main container portion, a first end portion, and a second end portion. The first and second end portions are detachably attached to the main container portion to define a chamber. The secondary container assembly comprising at least one secondary container. The secondary container assembly is sized and dimensioned to be stored within the main chamber.
US10232979B2 Quarter pallet with product tab receiving areas for products carried thereon
A pallet includes a top including a product support surface and an opposing underside, with outer sides extending between the product support surface and the underside. Four feet each extend away from the underside of the top, and each foot has a first opening facing out through the product supporting surface of the top. The feet thus allow stacking of such pallets with the feet of a first such pallet extending into the first openings of a second such pallet. Product tab receiving areas are for receiving respective product tabs, with each product tab receiving area having a slot within the top adjacent a respective outer side of the top. The slot has a pair of spaced apart opposing long sidewalls and a pair of spaced apart opposing short sidewalls adjacent to the pair of long sidewalls, with one of the long sidewalls including a laterally extending tongue for engaging an opening in one of the product tabs.
US10232977B2 Cap with a tamper evidence and a spout
A cap arranged to interact with a spout. The cap includes a top section, a side wall section attached to the top section and a tamper element attached to the side wall section in a tearing interface. The tearing interface may be provided with a weakening line that is arranged to break when the cap is unscrewed such that the tamper element is separated from the side wall section. The cap further includes at least one resilient cutting element arranged to the side wall. The at least one resilient cutting element is arranged to cut off a membrane of the spout when the cap is unscrewed. The cap is arranged such that the weakening line is arranged to break before the membrane of the spout is cut off when the cap is being unscrewed from the spout.
US10232970B2 Hold-open device and package having same
A device for selectively retaining a package opening in a gaping configuration and a package including the device applied to a package body. The device includes a circumferential strip with side seams formed as vertical or longitudinal hinges. One or more tabs extend in a first axial direction from an upper edge of the circumferential strip at the side seams. Each tab is coupled to the circumferential strip with a horizontal or transverse hinge. The tabs are pivotable about the horizontal or transverse hinges in opposite directions away from the opening axis to respective folded-out positions, which inhibits the device from folding at the side seams and retains a gaping open configuration of the device and package. The vertical hinges include thru cuts or line of perforations that go through the entire material thickness of the circumferential strip and the one or more tabs and extend for a majority of the full axial length of the device. The horizontal hinges may be in the form of a living hinge or alternatively thru cuts or a line of perforations.
US10232968B2 Packaging methods
A packaging apparatus comprising a base surface, in turn comprising a first end and a second end is disclosed. The packaging apparatus further comprises a feed tube between the first end and the second end of the base surface, a transporter between the first end of the base surface and the feed tube, a first sealer between the feed tube and the second end of the base surface, and a second sealer between the first sealer and the second end of the base surface.
US10232966B2 Machine for creating and filling a multi-compartment pouch simultaneously with powder and liquid
A packaging machine forms, fills and seals a mixing pouch that includes a first compartment containing a liquid ingredient and a second compartment containing a light powdered ingredient with a breakable seal, preferably formed by an adhesive heat seal, between the two compartments to separate the two ingredients. The machine creates a breakable seal that can be ruptured to form a common interior cavity and allow the mixing of the two ingredients to create a mixed product. One end of the mixing pouch can be formed with a dispenser through which the mixed product is discharged for use. The mixing pouch is a flexible plastic member formed from two opposing plastic sheets, sealed through heat dies and supplied with powdered and liquid components before being completed. The operation of the machine is automated and powered through pneumatic cylinders. Alternatively, the compartments could be filled with different liquid components.
US10232958B2 Landing gear shock absorber servicing
A method and apparatus for servicing a shock absorber on a landing gear assembly of an aircraft in a weight-on-wheels state is disclosed. The shock absorber includes at least one chamber containing both hydraulic fluid and a gas in fluid communication with each other. The apparatus includes a source of gas and a source of hydraulic fluid. The amount of hydraulic fluid in the chamber is corrected, preferably such that the chamber is then filled with a known amount of degassed hydraulic fluid. The process may be at least semi-automatically performed, for example under the control of a control unit. By delivering a pre-set mass of gas into the chamber, there is no need to rely on a measure of gas pressure or H-dimension (h) when servicing the shock absorber, and more accurate servicing of a shock absorber may thus be provided.
US10232955B2 Portable balloon launch rig
A portable launch rig (PLR) may include a support structure including two side supports defining an interior space for lifting and filling a balloon envelope of a balloon. Wheels on each of the side supports enable the PLR to be moved in various directions in order to prepare the PLR for launching the balloon. The side supports are connected by a lateral support beam having a pair of cranes arranged thereon. Each crane has an arm arranged over the interior space that is connected to a spreader beam. The spreader beam includes a lift assembly configured to lift and inflate the balloon envelope within the interior space. The PLR includes a platform and perch for supporting and moving the balloon envelope. A door assembly of the PLR includes a plurality of hangar doors configured to block wind from a respective direction of each hangar door entering the interior space.
US10232954B2 Apparatuses and methods for reducing ozone creation from ultraviolet (UV) light
Apparatuses and methods are described for use of an ultraviolet (UV) light source, such as in a cleaning device, in which ozone creation due to reaction of the UV light with oxygen in the air is reduced. An example method includes dispersing, by a gas outlet, oxygen-depleted gas over a UV light source, and directing UV light from the UV light source to pass through the oxygen-depleted gas onto an area. An example apparatus includes a UV light source to direct UV light onto an area, and a gas outlet to disperse oxygen-depleted gas over the UV light source, such that the UV light passes through the oxygen-depleted gas onto the area.
US10232952B2 Method for three-dimensional graphic representation of a landing runway on an aircraft display device
The general field of the invention is that of the methods for three-dimensional graphic representation of at least one landing runway on a display device of an onboard display system for aircraft, said graphic representation being displayed in a synthetic of an outside landscape, said runway comprising a coloured rectangular form, an outline surrounding said form and markings the position of the aircraft in relation to said runway being known in a horizontal plane with a first accuracy and in a vertical axis with a second accuracy. When the first accuracy is above a first threshold and/or when the second accuracy is above a second threshold, the appearance of the rectangular form or of the outline or of at least one marking is modified.
US10232948B2 Mixing bleed and ram air at a turbine inlet of a compressing device
An air conditioning system for an aircraft is provided. The air conditioning system includes a first rotating component and a second rotating component. The first rotating component includes a compressor and a turbine. The compressor pressurizes a first medium. The first turbine receives a mixture of a second medium and a pressurized form of the first medium. The second rotating component includes a fan.
US10232945B2 Seat particularly for a passenger transport vehicle
Disclosed is a seat intended in particular for a passenger transport vehicle, the seat including a seating part, a backrest that pivots relative to the seating part, a headrest, and an active noise control device including: at least one error sensor capable of sensing a minimization acoustic field and generating a reference signal; a reference sensor able to capture an undesirable acoustic field; a processing unit able to generate a cancellation signal from the reference signal and from a signal representative of the undesirable acoustic field; and at least one speaker able to emit a cancellation acoustic field from the cancellation signal. The headrest includes a support and a first deformable casing carried by the support. The at least one error sensor is arranged on the first deformable casing.
US10232943B2 Aircraft passenger seat
An aircraft passenger seat (100) is fixed to a floor via a seat track fitting (110), and a reclining assembly of the seat is supported by pipes (130, 132) passed through left and right legs (120) and spreaders (170). A linear actuator (300) operates a reclining motion. A curved arm for deformation is provided to a mount (320) on which the actuator (300) is mounted, and a slit (145) is provided in a link plate (140) to which a rod is connected, and in a state where a forward force F is applied, the curved arm deforms and absorbs the impact. An impact absorbing structure is also provided to the legs (120).
US10232938B2 Unmanned supply delivery aircraft
A heavy payload, autonomous UAV able to deliver supply by way of airdrop with more precision and at a lower cost. The UAV can be equipped with a movable wing system. The UAV can include a removable storage box. The UAV can be equipped with a drogue parachute for deploying the wings upon jettison of the UAV from a mothership. The UAV can be controlled remotely or it can operate autonomously. The UAV can include canard wings. The canard wings and the movable wings can include ailerons to effectuate flight control of the UAV. The UAV can be reusable or can be an expandable UAV. The UAV's wings can be configured to automatically separate from the UAV during the landing sequence.
US10232934B2 Wing tip with optimum loading
A wing tip designed for attachment to a winglet of an aircraft, the winglet coupled to a wing of the aircraft and having a leading edge and a trailing edge continuously transitioning from a leading edge and trailing edge of the wing. The wing tip may include a curved leading edge from the winglet leading edge to a leading end point, a curved trailing edge from a winglet trailing edge to a trailing end point, and an end segment connecting the leading end point and the trailing end point. The end segment may be swept back from the trailing end point to the leading end point at an end segment angle.
US10232932B2 High stiffness hub assembly for proprotor systems
A high stiffness hub assembly for a proprotor system operable to rotate with a mast of a tiltrotor aircraft having helicopter and airplane flight modes. The hub assembly includes a yoke and a constant velocity joint assembly. The yoke has four blade arms each adapted to hold a proprotor blade. The constant velocity joint assembly provides a torque path from the mast to the yoke that includes a trunnion assembly, four drive links and four pillow blocks. The trunnion assembly is coupled to the mast and has four outwardly extending trunnions. Each drive link has a leading bearing coupled to one of the trunnions and a trailing bearing coupled to one of the pillow blocks. Each pillow block is independently mounted between an upper surface of the yoke and a hub plate with two connection members that extend through the yoke and the pillow block.
US10232931B2 Selecting propellers for performance and noise shaping
Aerial vehicles may be operated with discrete sets of propellers, which may be selected for a specific purpose or on a specific basis. The discrete sets of propellers may be operated separately or in tandem with one another, and at varying power levels. For example, a set of propellers may be selected to optimize the thrust, lift, maneuverability or efficiency of an aerial vehicle based on a position or other operational characteristic of the aerial vehicle, or an environmental condition encountered by the aerial vehicle. At least one of the propellers may be statically or dynamically imbalanced, such that the propeller emits a predetermined sound during operation. A balanced propeller may be specifically modified to cause the aerial vehicle to emit the predetermined sound by changing one or more parameters of the balanced propeller and causing the balanced propeller to be statically or dynamically imbalanced.
US10232929B2 Plate member for reducing drag on a fairing of an aircraft
A rotary wing aircraft includes a fuselage having a plurality of surfaces, at least one engine mounted in the fuselage, and a rotor assembly including a rotor shaft and plurality of rotor blades operatively connected to the rotor shaft. The rotor assembly includes a plurality of surface portions. A rotor shaft fairing extends between the fuselage and the rotor assembly and about at least a portion of the rotor shaft. The rotor shaft fairing includes an outer surface. A plate member is mounted to and projects proudly of the at least a portion of the rotor shaft fairing. The plate member is configured and disposed to increase an aspect ratio of and reduce induced drag on the rotor shaft fairing as well as reduce rotor hub wake size.
US10232927B2 Signal initiation for aircraft doors
A signal-initiation device for initiating control signals in an aircraft fuselage, an aircraft fuselage including a signal-initiation device of such a type, an aircraft including such a fuselage, and the use of a signal-initiation device of such a type. The signal-initiation device for initiating control signals in an aircraft fuselage comprises a switching area configured to generate at least one control signal for controlling at least one orifice shutter present in the aircraft fuselage; and an initiating component connected to the switching area, configured to introduce the at least one control signal into the aircraft fuselage.
US10232919B2 Multi-vessel process to install and recover subsea equipment packages
According to one or more embodiments disclosed herein is a method of transporting equipment between sea-surface and seafloor by providing a structure with a subsea equipment package mounted thereon. The structure is used for installation and recovery in a subsea environment by changing the buoyancy of the structure or ballasting the structure to effect a controlled sinking motion.
US10232916B1 Barge chocking system
A chocking system, which is both removable and readily adjustable, for providing additional transverse restraint to cargo during transit. The chocking system may be utilized when the size and weight of the cargo requires additional restraints beyond the typical lashing gear, for example, the transportation of barges on a ship.
US10232914B1 Pressure activated time-delayed release
A pressure activated time-delayed release device and method. The device includes a body having a drive chamber and a compression chamber disposed therein, a drive piston disposed within the drive chamber of the body, and a compression piston disposed within the compression chamber of the body. A throttle mechanism is disposed between the drive piston and the compression piston. The throttle mechanism controls a release of viscous fluid from the drive chamber into the compression chamber. The drive piston and compression piston are connected so as to cause the compression piston to move substantially simultaneously with the drive piston to compress a compressible element disposed within the compression chamber. The device moves from an un-actuated state to an actuated state when the device is exposed to a predetermined water pressure for a predetermined period of time.
US10232908B2 Bicycle shaft transmission assembly
The present invention discloses a bicycle shaft transmission assembly including a bottom bracket engaged with a crank in a front part and a wheel hub in a rear part, a front main gear mounted on the bottom bracket, a rear main gear mounted on the wheel hub, a transmission shaft eccentrically arranged between the front main gear and the rear main gear. The front main gear is matched with a front end gear, and the rear main gear is matched with a rear end gear. The front main gear is externally provided with a front housing, the transmission shaft is externally provided with a transmission shaft housing, the rear main gear is externally provided with a rear housing, a front end of the transmission shaft housing is engaged with the front housing, a rear end of the transmission shaft housing is engaged with the rear housing.
US10232899B1 Virtual stop station
A virtual stop station is provided having a carriage straddling an assembly line operation. This provides an independently moving platform upon which one or more manufacturing robots are affixed. The carriage is coordinated with and tracked to the linear motion of the assembly line. A vision guidance system centers the workpiece, and lifting arms mounted on the moving carriage will locate the workpiece and lift the workpiece up off of the conveyor, while being coordinated with it. The workpiece and robots thus are now fixtured to the same frame, thus eliminating movement relative to one another creating a virtual stop station. Once subassembly is complete, the coordinated robotic gantry will disengage from the conveyor and return home. The instant abstract is neither intended to define the invention disclosed in this specification nor intended to limit the scope of the invention in any way.
US10232890B1 Control mechanism for bottom shield of cotton harvester
A plant shield assembly includes an elongated shield having a first door operably connected to a second door and both doors are pivotally connected to the vehicle and movable between an open position and a closed position. The plant shield assembly includes a door opening mechanism operably attached to the elongated shield and configured to move the first and the second doors. The plant shield assembly includes a linkage assembly that connects the elongated shield with the door opening mechanism, and limits the extent of rotation of the doors. The door opening mechanism and linkage assembly are positioned between the elongated shield and the vehicle. The door opening mechanism can be a handle attached to the elongated shield. Optionally, the plant shield assembly includes an access door that is disposed between an open position to enable actuation of the handle and a closed position to block actuation of the handle.
US10232887B2 Front vehicle-body structure of vehicle
A front vehicle-body structure of a vehicle comprises a front frame, an apron reinforcement, and a suspension housing, wherein the front frame includes a frame outer and a frame inner, the frame outer and the frame inner having respective upward projection portions which are joined together to form a flange portion of the front frame, the suspension housing includes an outward-side joint portion which is joined to an outer face of the front frame and an inward-side joint portion which is joined to an outward side face, in the vehicle width direction, of the flange portion, the outward-side joint portion and the inward-side joint portion being aligned in the longitudinal direction.
US10232884B2 Chassis and method of designing main beam for same
A method for designing a main body of a trailer, trailer chassis, or like transportable load-supporting system includes selecting a known design of a transportable load-supporting system's main frame. The method includes developing a monocoque main beam having moments of inertia that are respectively greater than or substantially equal to the moments of inertia of the known main frame. Deflections of the known main frame and of the monocoque main beam in response to application of a torsional load, a vertical load, and a lateral load are then determined. Cross-members can be added to the monocoque main beam until the deflection of the monocoque main beam is less than or substantially the same as the deflection of the known main frame. A monocoque main beam designed according to the method is also disclosed.
US10232879B2 Communication system
A communication system includes a sensor apparatus, which includes sensing elements and a transmission circuit, and a microcomputer, which includes a reception circuit, a difference calculator, and a differential calculator. The transmission circuit shifts a transmission time point of one of sensor signals including sensor value detected by one of the sensing elements by a predetermined period with respect to a transmission time point of another one of sensor signals including sensor value detected by another one of the sensing elements. The predetermined period is set shorter than a transmission cycle of the transmission circuit. The difference calculator calculates a difference value so that an offset error among the sensing elements is compensated or a fluctuation caused by a variation in slopes of output characteristics of the sensing elements is reduced.
US10232876B2 Method, system and computer program for controlling propulsion of a drilling rig as well as a drilling rig
A method for controlling propulsion of a drilling rig. The drilling rig includes a right propulsion unit and a left propulsion unit and mutually independent speed control and a transmission for driving the right propulsion unit and the left propulsion unit. The transmission provides at least two gear states of a gear box. A propulsion speed is request for the right propulsion unit and for the left propulsion unit. A difference is determined between a requested propulsion speed of the right propulsion unit and the left propulsion unit. A suitable gear state is determined based on the determined difference. Also a computer program product including program code for a computer for implementing the method. A system and a drilling rig equipped with the system.
US10232873B2 Methods and apparatus to identify non-uniformity in a vehicle steering system
Methods, apparatus, and articles of manufacture to identify non-uniformity in a vehicle steering system are disclosed. An example apparatus includes a first sensor to measure a steering wheel angle relative to a first universal joint, a second sensor to measure a pinion angle relative to a second universal joint, and a third sensor to measure a torque relative to a torsion bar. The apparatus further includes a non-uniformity manager to determine a non-uniformity angle associated with a steering column, the non-uniformity angle based on the torque and comparing the steering wheel angle to the pinion angle, map the non-uniformity angle to a first position of the steering column, and determine an offset to adjust a steering response based on the first position.
US10232861B2 Apparatus, method and system for controlling a user situation awareness modification of a user of a vehicle
The invention relates to an apparatus that is configured to receive a first user detection signal comprising information usable for determining a user situation awareness level. The apparatus also includes a processing module configured to determine a currently necessary situation awareness level by selecting one predefined situation awareness level from a plurality of predefined situation awareness levels based on driving information. The processing module is configured to determine a current user situation awareness level based on the information usable for determining the user situation awareness level. The processing module is configured to generate a control signal to control a user situation awareness modification module based on the currently necessary situation awareness level and the current user situation awareness level.
US10232856B2 Vehicle user-communication system and method
A controller includes a processor and a memory storing processor-executable instructions. The processor is programmed to control steering and at least one of propulsion and braking of a vehicle while following a route segment and, during the route segment, to activate a user interface at a frequency based on at least one of an elapsed duration of the route segment, an age of a user, a time of day, and a route-segment topology.
US10232854B2 Work vehicle
A transmission switching arrangement for a work vehicle includes a forward-reverse switching device having a plurality of hydraulic clutches for switching over a transmission state of a power transmission line including mechanical stepless speed change device, a electronic control unit for controlling operations of the forward-reverse switching device and the mechanical stepless speed change device, a switchover switch for commanding switchover of the transmission state by the forward-reverse switching device, and sensors for detecting a rotational speed of the power transmission line. Upon receipt of a command for effecting the switchover of the transmission state, the electronic control unit compares an output from the sensors with a set speed for transmission state switchover. When the output from the sensors is greater than the set speed, the electronic control unit reduces the rotational speed of the power transmission line and effects the transmission state switchover by controlling pressure of the plurality of clutches.
US10232852B2 Travel control apparatus
A travel control apparatus is provided with: a speed controller that controls speed of a vehicle having an internal combustion engine; and a determination part that determines an emission deterioration state of the internal combustion engine. The speed controller is configured to execute burn-and-coast control that repeatedly executes burn control in which the vehicle is accelerated by driving force of the internal combustion engine, and coasting control in which the vehicle is driven by inertia, by stopping the generation of the driving force or rotation of the internal combustion engine. The speed controller is configured to execute emission suppression control that suppresses emissions by adjusting the burn-and-coast control when the emission deterioration state of the internal combustion engine is determined by the determination part.
US10232851B2 Travel track creation device, method, and program, and driving assistance device and system
A driving assistance device that performs steering operation of a vehicle. The device includes a travel track creation device having a curvature waveform creator that creates a waveform representing a curvature of a reference travel track. A first changer changes first and second edge portions of the waveform to a ramp shape and provides the waveform with first and second ramp-shaped portions. A second changer changes each of the first and second ramp-shaped portions to a curve and provides the waveform with first, second, third, and fourth curve portions. A travel track creator creates the travel track based on the waveform. A controller provides a steering signal according to the travel track.
US10232843B2 Fuel maintenance guide system in hybrid vehicle
A fuel maintenance guide system in hybrid vehicles in which a shift to the fuel maintenance mode giving priority to consuming fuel is executed automatically under a predetermined condition regardless of intention of a driver, the fuel maintenance guide system including: a residual fuel detecting unit detecting a residual amount of the fuel; a cancel condition determining unit determining a cancel condition for cancelling the shift to the fuel maintenance mode, based on the residual amount detected by the residual fuel detecting unit; and a displaying unit displaying the cancel condition determined by the cancel condition determining unit from a predetermined time period before the shift to the fuel maintenance mode.
US10232841B2 Methods and system for improving response of a hybrid vehicle
Systems and methods for operating a driveline of a hybrid vehicle are disclosed. In one example, an engine may enter or stay in one of two cylinder modes in response to a request to a negative torque capacity of an electric machine being insufficient to provide a desired driveline braking torque. One cylinder mode operates cylinders with cylinder valves held closed and without fuel being injected to the cylinders while the other cylinder mode operates cylinders with valves that open and close without fuel being injected to the cylinders.
US10232840B2 Deceleration control for a hybrid vehicle during towing
A hybrid vehicle having an engine, an electric machine, and a step-ratio transmission includes a controller programmed to, in response to an accelerator lift-pedal event when operating in a towing mode, learn a vehicle speed, and apply a lift-pedal torque when vehicle speed exceeds the learned vehicle speed, and apply an adjusted lift-pedal torque based on a gear ratio after downshifting the transmission to maintain a constant output shaft torque otherwise.
US10232836B2 Actuator system and operating method for an actuator system
The invention relates to an actuator system, in particular an electromechanical parking brake system, comprising an actuator, wherein the actuator is driven by a direct current motor that can be driven in both directions of rotation, wherein a control unit for controlling the movement of the direct current motor in an open-loop or closed-loop manner is provided. The core of the invention is that one or more pieces of information are supplied to a control unit, said information allowing the application force exerted by the electromotive actuator to be determined and compared to a predetermined minimum application force, and wherein the control unit emits at least one piece of information, signal or the like for requesting an auxiliary actuation to peripheral systems, components and/or electronic control units after the target to actual value comparison has shown that the determined, set application force is smaller than the predetermined minimum application force.
US10232835B2 Brake system for vehicle
A brake system for a vehicle may include a brake input device configured to apply a brake input of a driver; a brake actuator including a first pump device and a second pump device for supplying a brake hydraulic pressure; a brake adjusting device, which includes a first chamber and a second chamber, and is operated so that the first chamber and the second chamber are connected to or blocked from each other; and wheel cylinders configured to generate brake power for each wheel by the brake hydraulic pressure generated in the brake actuator, wherein the brake adjusting device blocks the first chamber and the second chamber so that a brake hydraulic pressure supplied from the first pump device and a brake hydraulic pressure supplied from the second pump device are blocked from each other.
US10232834B2 Brake device
Provided is a brake device capable of maintaining pads and a rotor in a desired positional relationship. When receiving a release request within a time period from start of execution of an application request to detection of contact between brake pad and a disc rotor, a parking brake control device inhibits execution of the release request, and executes the release request after detection of the contact between the brake pad and the disc rotor. Further, when receiving the application request within a time period from start of execution of the release request to detection of separation between the brake pad and the disc rotor, the parking brake control device inhibits execution of the application request, and executes the application request after detection of the separation between the brake pad and the disc rotor.
US10232826B2 Flat wiper blade
Flat wiper blade for windscreen wiper modules, having a wiper blade body, which presents at least one wiping rubber (12) forming at least on e wiping lip (12.1), presents at least one spring rail (11) in addition to at least one retaining strip (10) on which the wiping rubber (12) is held and which (retaining strip (10)) possesses at least one profile section designed as a hollow profile, in which at least a partial length of the spring rail (11) is accommodated, wherein at least one heating foil (19) is arranged over at least a partial length together with the at least one spring rail (11) in the profile section (10.1) of the retaining strip (10).
US10232825B2 Wiper arm
A wiper arm including an arm head having an arm head body and cover member. The cover member is attached to the arm head body and can open and close. The mechanical strength of the arm head can be increased. The arm head includes a head cap which is rotatably attached to rotating shafts and provided on the inner side surfaces of both side sidewalls of an arm head body. When the head cap is in its closed position, a front-side half section of the head cap is disposed between both side sidewalls. On the rear surface of a rear-side half section of the head cap, a cylindrical cap-side fitting section is provided and fits with a nut disposed on the arm head body. The cap-side fitting section includes slits and is formed so that the height in its vertical direction decreases in a front-side portion.
US10232823B1 Apparatus and method for pairing smartphone with vehicle tracking device
A vehicle monitoring system prevents vehicle theft and unauthorized tampering by alerting the vehicle's owner of unexpected events. Alerts are provided to the owner within seconds of the occurrence while the owner is away from the vehicle. The vehicle monitoring can be set to automatically start whenever the vehicle is parked and the owner moves away to a specific distance. This allows the owner to set monitoring preferences once, after which the system automatically handles monitoring according to those preferences for future vehicle activities. The monitoring and alerting may be automatically disarmed when the vehicle owner again comes within the predetermined proximity of the vehicle. The monitoring may also be disarmed manually, such as when the owner lends the vehicle to another and does not need to track it. It also may be manually disarmed if the owner left his/her phone in a location far from the vehicle.
US10232822B2 Vehicle-mounted communication system, portable machine, and vehicle-mounted machine
Provided are a vehicle-mounted communication system with which a vehicle-mounted machine is able to continue receiving a wireless signal even if the signal is interrupted. When an ID signal, indicating identification information (ID) corresponding to a vehicle, and more than M (where M is a natural number) data signals, indicating control content, are caused to be included in a wireless signal by the portable machine, and the portable machine transmits the wireless signal, the portable machine adds the ID signal into the wireless signal each time M data signals have been transmitted, and continues to transmit the wireless signal. Meanwhile, each time the vehicle-mounted machine receives the ID signal included in the wireless signal, the vehicle-mounted machine verifies the identification information the received ID signal against identification information stored in a ROM, and continues to receive the wireless signal when there is a match.
US10232817B2 Vehicle seat side air bag assembly
A vehicle seat includes a frame, a cover, and a seat side airbag assembly. The seat side airbag assembly includes a chute mounted to the frame and extending to the cover. An airbag is fixed to the chute, with the chute extending between the airbag and the cover. The chute is attached to the cover.
US10232816B2 Vehicle seat having a side airbag device
A vehicle seat provided with a side airbag device including: a side airbag that is stored within a side portion of a seat back, and that receives gas supplied from an inflator so as to inflate and deploy at a side of a seated vehicle occupant; seat back upholstery that forms upholstery for the seat back, and in which a burst line portion, which is a seam portion, ruptures when it receives inflation pressure from the side airbag, and in which a three-way junction is formed in a seam portion as a result of a seam portion that branches off from the burst line portion being provided; and reinforcement fabric that is joined to both a portion of the burst line portion that bridges an intersection point of the three-way junction and a seat back frame, and that stretches when it receives inflation pressure from the side airbag.
US10232813B2 Method for operating a motor vehicle during an emergency call
The invention relates to a method for operating a motor vehicle, in which an emergency call of the motor vehicle is made and, through the emergency call, image data from at least one camera of the motor vehicle and state data from at least one vehicle component, which differs from the camera of the motor vehicle are sent out to a vehicle-external facility, wherein the state data is, before being conveyed to the vehicle-external facility, embedded into an image signal formed from the image data in accordance with a predetermined image coding standard, and the image signal with the embedded state data is sent out to the vehicle-external facility.
US10232810B2 Electrical connection box
Provided is an electrical connection box including a new structure, according to which, even in the case of using a component holding case in which terminal holding portions and electrical component mounting portions are integrated, engagement between connection terminal portions and supporting pins in a lateral component connection portion can be checked easily, and improvements in the workability and reliability of assembly and an improvement in work efficiency due to a reduction in the number of components can be achieved simultaneously. Through windows are provided in an upper wall portion of a component holding case so as to penetrate through positions opposing supporting pins arranged inside in a vertical direction.
US10232808B2 Wire harness
A wire harness includes a conductive path configured to electrically connect between high-voltage devices. The conductive path includes a main line and a branch line that branches from the main line. An overcurrent cut-off portion is disposed on a way of the branch line to cut off an overcurrent.
US10232804B2 Acoustic protection cover for encapsulating a motor vehicle component
An acoustic protection cover for encapsulating a motor vehicle component, the cover including: a based on injection-molding material, the material comprising a thermoplastic matrix and a filler that is dispersed in such a way as to exhibit a density of between 1.3 and 1.6, the shell comprising two half-shells delimited by a thin region originating from the molding and forming a flexible hinge; a layer of elastically compressible foam overmolding the internal face of the shell, so that the cover forms an insulation system of the “mass-spring” type, the mass being formed by the shell and the spring by the layer; a means of holding the half-shells together once the hinge has been folded, so as to allow the component to be encapsulated, the matrix being made of polyvinyl butyral (PVB) and the level of filling being less than or equal to 50% by mass of the material.
US10232802B2 Vehicle interior panel with compressible layer of non-uniform thickness
A vehicle interior panel includes an elastically compressible layer between a substrate and a decorative skin layer. The compressible layer has a non-uniform thickness along which voids are formed within the thickness of the panel. A center console can be equipped with the panel in the form of a tambour door that opens to access a storage space in the console and closes to serve as a cushioned armrest. The compressible layer can be formed from a foam material molded directly onto the decorative layer and shaped as a series of projections that are attached to flexibly interconnected crossmembers of the substrate. Thin portions of the compressible layer between the projections facilitate reversible bending of the panel during movement along curved guides.
US10232800B1 Camera module
A camera module, which is mounted on an inside of a front windshield of a vehicle and configured to image an external environment of the vehicle, includes multiple lens units on which an optical image of the external environment is incident, individually, and an imaging system to generate an outside image of the external environment by imaging through each of the lens units, individually.
US10232799B2 Cameras and camera housings for vehicle trailers
Method and apparatus are disclosed for cameras and camera housings for vehicle trailers. An example camera for vehicle trailers includes a casing. The casing defines a cavity and includes a first face defining a first window and a second face defining a second window. The example camera also includes a core including a lens and coupled to the casing within the cavity via an axle. The core rotates to enable capturing of images through the first window and the second window. The example camera also includes gears within the cavity to facilitate rotation of the core.
US10232792B2 Lifting and transferring apparatus and method
A lifting and transferring apparatus and method are disclosed. In some embodiments, the apparatus may be realized as a power lift and transfer system which has the capability of attaching to, lifting, and carrying a mobility device for a person with a disability in conjunction with a wide variety of vehicles. The unique design of the apparatus eliminates a typical platform structure that is often incorporated by other devices and substitutes an interlocking mechanism which comprises a docking device on the personal mobility device and a mated receiver on the apparatus, thus saving significant weight and bulk. A unique swivel swing-away design incorporates a swing away hinge in a space between a hitch and the apparatus instead of in a space between the apparatus and the mobility device and platform.
US10232790B1 Secure storage device
A secure storage device is presented. The secure storage device comprises walls, a bottom, a door and an opening for forming an interior chamber for storage. The device may be constructed of a variety of materials, including but not limited to aluminum, steel, impact-resistant materials, and bullet-proof materials. It at least one embodiment, the secure storage device is configured to act as a sun visor for a vehicle for securely storing a weapon.
US10232788B1 Storage bin
A vehicle seating assembly includes a seat that is pivotable between an open position and a closed position. A cavity is formed in a support structure of the seat such that an occupant is supported on a support rib.
US10232787B2 Second row seat dump handle bezel integrated light
A seating assembly includes a seatback. A seat includes a top side that defines a seating surface and a bottom side that includes an attachment interface. The seat is operably coupled with the seatback and is rotatable between a horizontal orientation and a vertical orientation. A closeable pocket is removably coupled with the attachment interface of the seat. The closeable pocket includes a zipper. A handle operably disengages a latching mechanism of the seat and is disposed above the closeable pocket. The handle includes a peripheral bezel with a light source, which is a light emitting diode, configured to illuminate the closeable pocket and a cargo space disposed below the seat.
US10232784B1 Tubular console
A motor vehicle console comprises a mount and a pair of exposed parallel tubular members. Each of the tubular members has a forward horizontal section, an intermediate section extending rearwardly in at least partially an upward direction, and a rearward horizontal section, wherein each forward horizontal section is disposed at an elevation horizontally below the rearward horizontal section and each forward horizontal section is operatively coupled with the mount.
US10232778B2 Adjusting instrument, exterior mirror unit, motor vehicle
Adjusting instrument for an exterior mirror of a motor vehicle, comprising a foot for attachment to a fixed element of the motor vehicle, and a housing adjustably connected with the foot, the housing being adjustable around a rotation axis extending through the adjusting instrument, while around the rotation axis a passage opening is provided for passing through a cable tree, the housing being provided with a slot along a height thereof which provides lateral access to the passage opening and the foot being provided with a slot along a height thereof which provides lateral access to the passage opening, the housing being furthermore adjustable relative to the foot into an assembly position in which the slot of the foot aligns with the slot of the housing to provide lateral access to the passage opening for laterally introducing a cable tree into the passage opening.
US10232777B2 Mirror adjustment mechanism, in particular for a wing mirror for a motor vehicle
A mirror adjustment mechanism, in particular for a wing mirror for a motor vehicle, having a base part with a mirror support arranged pivotally relative thereto, wherein between the base part and the mirror support a damper is arranged, the damper including a collar portion coupled to the mirror support, encompassing a ball portion, coupled to the base part, or vice versa, both constituting a ball joint arrangement. A slide element is slidingly engaged between the ball portion and the collar portion in such a way that it restrains movement of the collar portion relative to the ball portion, resulting from movement the mirror support relative to the base part, wherein the slide element is a spring ring slidingly abutting on contact surfaces of the ball portion and coupled to the collar portion.
US10232775B2 Electric drive vehicle
An electric drive vehicle is provided with first and second slider plates contacting a trolley line on the high-voltage side and on the ground side, respectively. A camera has a photographing range of the whole of the second slider plate held in contact with the trolley line on the ground side and a part of the trolley line residing around the second slider plate. A controller controls a display of a monitor, wherein the controller includes a relative distance calculation section that calculates a relative distance between the trolley line on the ground side and a reference position of the second slider plate, and a bird's eye view image data generation section that generates bird's eye view image data reflecting the relative distance calculated by the relative distance calculation section and that outputs the bird's eye view image data to the monitor.
US10232772B2 Driver assistance system
A driver assistance system according to the present invention has an other-vehicle information acquisition unit that acquires travel direction information of an other-vehicle; a storage unit in which a spot where the visibility of a driver in a vehicle is reduced and information on a direction, associated with the spot, in which the visibility of the driver of the vehicle is reduced are stored in association with each other; a visibility determination unit that determines whether or not the visibility of a driver in the other-vehicle is reduced on the basis of the travel direction information acquired by the other-vehicle information acquisition unit and the information on the direction in which the visibility is reduced stored in the storage unit; and a warning processing unit that warns a driver of an own-vehicle that the visibility of the driver in the other-vehicle is reduced if the visibility determination unit determines that the visibility of the driver in the other-vehicle is reduced.
US10232770B2 Illuminated marker
Disclosed is an illuminated marker device including: an inner surface; an outer surface, the outer surface including a first portion and a second portion, the first portion being translucent; and a post, the post extending from the inner surface away from the outer surface. Also disclosed is an illuminated marker device including: an inner surface; an outer surface, the outer surface including a graphics portion and a background portion, a one of the graphics portion and the background portion including a photoluminescent material; and a post, the post extending from the inner surface away from the outer surface.
US10232769B2 Vehicle cup holder assembly
A vehicle cup holder assembly is provided and includes a cup holder. A cup holder bezel is coupled to the cup holder and has an optical element that receives light and a reflective element that partially encloses the optical element and redirects light propagating inside the optical element, wherein light escapes through a light transmissive region of the optical element.
US10232768B2 Lane change assist device for a vehicle
When a start acceptance condition for lane change assist control (LCA) is established (S12: Yes), a driving support ECU starts transmission of a turn signal flashing command to a meter ECU (S13). In this manner, flashing of a turn signal can continue even when a driver separates his or her hand from a turn signal lever. When a turn signal turning-off condition is established under a situation in which the LCA is executed (S15: Yes), the driving support ECU stops the turn signal flashing command that has been transmitted so far (S16). With this, the flashing of the turn signal can be ended even when the driver does not perform a returning operation on the turn signal lever.
US10232761B2 Unmanned underwater vehicle transport cart
An unmanned underwater vehicle (UUV) transport cart comprising: a wheeled frame including vertical posts, a front end, and a rear end; a UUV cradle adjustably clamped to the vertical posts such that the UUV cradle is vertically adjustable with respect to the frame; a U-shaped handle pivotally attached to the front end of the frame such that the U-shaped handle pivots up and down around a first axis, wherein the U-shaped handle includes a handle spring that acts between the U-shaped handle and the frame so as to bias the U-shaped handle toward an upward orientation; side handles pivotally attached to the UUV cradle such that the side handles pivot up and down around side axes that are perpendicular to the first axis; and a hand brake affixed to the U-shaped handle and configured to provide active brake control of the wheeled frame.
US10232760B2 Apparatuses, watercraft supports, and methods therefor
Apparatuses, watercraft supports comprising the apparatuses, and methods of loading watercraft on the watercraft supports for promoting centering of a watercraft while loading the watercraft onto a watercraft support. The apparatuses include at least two units each having a rigid arm having first and second ends and a barrier component configured to float on water. The first end of the rigid arm is configured to be secured to a watercraft support such that the rigid arm pivots relative to the watercraft support. The second end of the rigid arm is configured to be secured to the barrier component such that the rigid arm pivots relative to the barrier component. The units may be located adjacent to oppositely-disposed longitudinal sides of the watercraft support and used to directing the watercraft to be centered over the watercraft support during loading from a body of water.
US10232757B2 Pick-up truck cargo lift system and method
A cargo lift system and method for a pickup truck or similar vehicle. The apparatus fits within the cargo box of a pickup truck and can be deployed to positions above and below the cargo bed. The system includes a set of movement synchronizers configured to synchronize movement of the lifting and lowering structures to prevent binding and racking during operation, thus allowing the construction of the apparatus to be more compact and lighter in weight.
US10232754B2 Vehicle seat with a movable backrest and method for moving a backrest
The present application relates to a vehicle seat (1) comprising a seat surface (2) and at least one rest part (3.1, 3.2) at an angle to the seat surface (2). The angle between the seat surface (2) and the at least one rest part (3.1, 3.2) is movable via an adjusting device (6, 13) between a first position, in which the at least one rest part (3.1, 3.2) is substantially at right angles to the seat surface (2), and a second position, in which the seat surface (2) and the at least one rest part (3.1, 3.2) form a substantially flat surface. A second end (10.1, 10.2) of the at least one rest part (3.1, 3.2) comprises at least one pneumatic cushion (4) which is fluidically connected to a pump (7), wherein a control device is configured such that the pneumatic cushion (4) is substantially completely emptied when the at least one rest part (3.1, 3.2) moves from the first position into the second position.
US10232747B2 Mobile office seatback module
A vehicle seating assembly includes a seat operably coupled with a seatback. The seatback includes an adjustable headrest. A back panel is disposed on a rearward side of the seatback. The back panel includes engagement features removably coupled with a workstation. The workstation includes a plurality of connection features. The connection features includes a mechanical connector, a data connector, and a power connector. An upper support abuts a rear surface of the headrest. An open receptacle is disposed proximate the headrest. An intermediate compartment is disposed adjacent the open receptacle and concealed by first and second opposing doors. A lower compartment is concealed by a bottom door.
US10232745B2 Actuating module for a vehicle seat
A module for a vehicle seat comprises a drive cable, an actuator, and a transmission assembly. The actuator is coupled to the transmission assembly to drive the transmission assembly. The drive cable is coupled to the transmission assembly and moves as a result of the actuator being activated.
US10232740B1 Adjustable seatback recline angle and warning system
A method of correcting a seatback recline angle is provided. The method includes a vehicle seat having a seat portion and a seatback portion, wherein the seatback portion is configured to recline to a plurality of reclined positions. The method further includes the steps of (a) measuring a recline angle of a seatback; (b) comparing the recline angle of the seatback to a predetermined recline angle threshold; (c) determining if the recline angle exceeds the recline angle threshold; (d) providing a warning to a seat occupant when the recline angle exceeds the recline angle threshold, wherein the warning is configured to prompt a corrective action from the seat occupant; and (e) moving the seatback to a corrected position when the corrective action from the seat occupant is not received after a predetermined period of time.
US10232738B2 Fastening device for a conductor rail and contact line system
A fastening device for a conductor rail and a contact line system having fastening devices to which the conductor rail is fastened. The fastening device is in the form of a plastic component. The plastic component has sliding jaws which enclose the conductor rail laterally and can be fixed in a position in which they enclose the fastening piece of the conductor rail from both sides. The fastening device can be produced inexpensively by methods known from plastic processing, for example injection molding methods. Further advantages arise from the fact that plastic material is an electrical insulator. In addition, the plastic material allows the conductor rail to be adjusted in a sliding manner in the fastening device before it is fastened.
US10232737B2 Motor vehicle and steering wheel thereof
The present invention provides a steering wheel including a main body and a vehicle speed control module positioned on the main body. The vehicle speed control module includes a stator, a rotor coaxial to the stator and rotatable relative to the stator, and a first contact lever positioned on the rotor. The rotor includes a Hall element configured to detect a rotational position of the rotor, and generate a Hall signal according to the rotational position of the rotor. When the first contact lever is rotated in a counterclockwise direction relative to a first initial position, the rotor is driven by the first contact lever to rotate, the Hall element outputs a first Hall signal to a controller of a motor vehicle, and the controller controls the motor vehicle to move forward. The present invention further provides a motor vehicle having the steering wheel.
US10232734B2 Linear motor motion stage with passive reaction force compensation function
Provided is a linear motor motion stage having a passive reaction force compensation function. The linear motor motion stage includes: a base; a magnet track moving on the base; a mover which is moved on a surface of the magnet track by an electromagnetic force generated in a gap with the magnet track; first and second horizontal springs arranged between one side and the other side, respectively, of the magnet track and the base and configured to attenuate a reaction force applied to the base by movement of the mover; and a cross spring arranged between a lower side of the magnet track and the base and configured to attenuate the reaction force. Herein, the linear motor motion stage controls reaction force compensation applied to the linear motor motion stage by controlling the stiffness of the cross spring.
US10232733B2 Power system of electric vehicle, electric vehicle comprising the same and method for heating battery group of electric vehicle
A power system of an electric vehicle, an electric vehicle including the same, and a method for heating a battery group of the electric vehicle are provided. The power system includes: a battery group; a battery heater connected with the battery group; a battery management device, configured to control the battery heater to heat the battery group when a temperature of the battery group is lower than a first heating threshold and a residual electric quantity of the battery group is larger than a running electric quantity threshold, to obtain a current throttle depth change rate of an electric vehicle in real time, and to control the battery heater to stop heating the battery group when the current throttle depth change rate reaches a preset throttle depth change rate threshold; an electric distribution box; a motor; a motor controller; and an isolation inductor.
US10232732B2 System and method for battery control using RMS current
A method according to an exemplary aspect of the present disclosure includes, among other things, monitoring a root mean square (RMS) current of a component for a time window, and adjusting a flow of current relative to a battery such that a slope of the RMS current gradually approaches zero as the RMS current approaches an RMS current limit for the time window.
US10232731B2 Battery pack management system with selective battery module heating
A system is provided that selectively heats the battery or battery module with the lowest voltage when the battery pack is at a low charge level, thereby decreasing the internal resistance and mitigating the magnitude of the voltage drop of the affected battery/battery module. As a result, termination of the battery pack's discharge cycle is delayed and the driving range of the vehicle is increased, thereby giving the driver a little more time and driving range to reach a charging station.
US10232730B2 Control of a secondary battery with battery cells which can be connected in series with one another
The invention relates to an open-loop and/or closed loop control system (1) for a secondary battery (3). Each cell electronics unit (4) is configured to detect a respective state of the battery cell (2), to generate a state parameter assigned to the respectively detected state, to weight, with the respective state parameter, a value of a probability of the battery cell (2) being switched on and to control the state of the battery cell (2) as a function of the respective control signal and the value, weighted with the respective state parameter, of the probability of the battery cell (2) being switched on. A control signal contains at least one information item according to which the values, stored in the cell electronics units (4), of the probability of the respective battery cell (2) being switched on are retained, incrementally increased, incrementally reduced or reset to a predefined output value.
US10232729B2 Apparatus and method for controlling charging battery
A battery charging control apparatus of an electric vehicle includes an air conditioning control device that controls an operation of an air conditioning device, a control device that receives global positioning system (GPS) information of a user terminal, which approaches a vehicle, and to generate charging control information based on a distance that is determined based on the GPS information of the user terminal and location information of the vehicle, and a battery charging device that controls an amount of current to be supplied to a battery and the air conditioning control device, based on the charging control information.
US10232728B2 Electrochemical composite storage system
The invention relates to an electrochemical composite storage system and to an electrical circuit comprising an electrochemical composite storage system of this type. The circuit and system comprise branches (ST1, ST2, ST3, ST4, ST5, ST6), which are connected in parallel, of electrochemical storage modules (10), said storage modules (10) having first connection terminals and each module having an electrical circuit. The composite storage system is designed to operate the branches (ST1, ST2, ST3, ST4, ST5, ST6) inside the composite storage system optionally as a current source or a voltage source, by means of the electrical circuits.
US10232726B2 Vehicle charger and control pilot signal detection method thereof
A control pilot (CP) signal detection method for a vehicle charger includes: counting CP signals based on signal levels of the CP signals during a set period of time, when an input of the CP signals is detected while an ignition of a vehicle is turned off; determining whether a count of high-level CP signals among the CP signals is within a reference range, when the set period of time elapses; and outputting state information of the CP signals based on the determination of whether the count of high-level CP signals is within the reference range.
US10232724B2 Electric vehicles and charging stations
The invention relates to systems and methods for charging a vehicle. A vehicle and charging station can be designed such that an electric or hybrid vehicle can operate in a fashion similar to a conventional vehicle by being opportunity charged throughout a known route.
US10232720B1 Vehicle
Provided is a vehicle in which an electric power storage device is mounted and which is configured to execute external charging. The vehicle includes an inlet connected to a charging connector, a cable lock mechanism disposed near the inlet and switching between a lock state and an unlock state, and a control device selecting a first mode in which the electric power storage device is allowed to be charged at a first current value in a case where the cable lock mechanism is in the lock state with the charging connector and the inlet connected to each other and selecting a second mode in which the electric power storage device is allowed to be charged at a second current value in a case where the cable lock mechanism is in the unlock state with the charging connector and the inlet connected to each other.
US10232717B2 High voltage on-board network structure for vehicles
A power supply system (2) for vehicles, comprising an electric machine (6), a DC-AC converter (8) having a DC connection and an AC connection, and an energy storage element (4) wherein the energy storage element (4) can be connected to the DC connection and the electric machine (6) can be connected to the AC connection, wherein the electric machine (6) can be operated using the energy stored in the energy storage element (4), characterised in that a DC-DC converter (14) is arranged between the energy storage element (4) and the converter (8) and an external power supply (12) can be coupled into the DC-DC converter (14) for charging the energy storage element (4) wherein the DC-DC converter (14) can be uncoupled from the converter (8) in the event of power supply.
US10232716B2 Power supply device
A power supply device that converts inputted direct-current power to direct-current power with a predetermined voltage to supply the power to the outside includes a voltage conversion circuit that converts the voltage of the inputted direct-current power, a voltage measurement circuit that measures a voltage value indicating a voltage potential difference between a ground voltage potential in the power supply device and a ground point provided outside the power supply device and connected to the ground voltage potential via a ground strap cable, a current measurement circuit that measures a current value of a load current flowing when de direct-current power is supplied from the power supply device, and an arithmetic circuit that calculates a resistance value corresponding ground connection of the power supply device, based on the voltage value measured by the voltage measurement circuit and the current value measured by the current measurement circuit.
US10232714B2 Motor vehicle operating device with controller to provide bounce suppression for actuating element
An actuating element, actuator device, and a control device are included in an operating device for a motor vehicle. The actuating element detects a user actuation and is movably mounted. The actuator device has an electromagnet and a permanent magnet. The control device applies a first electrical current to the electromagnet, by which the electromagnet applies a first magnetic force to the permanent magnet, which deflects the actuating element out of a rest position. The deflection of the actuating element can be felt as a brief jolt without reverberation. An elastically deformable restoring device presses or pulls the actuating element with a restoring force toward the rest position against a mechanical stop element.
US10232710B2 Wireless data sharing between a mobile client device and a three-dimensional heads-up display unit
The disclosure includes a system and method for wireless data sharing between a mobile client device and a three-dimensional heads-up display unit. A system may include a three-dimensional heads-up display unit (“3D HUD”) installed in a vehicle. The system may include a memory storing instructions that, when executed, cause the system to: establish a peer-to-peer video stream between a mobile client device and the vehicle; generate live video data for providing a video stream for causing a screen of the mobile client device to display visual content of the 3D HUD that includes substantially live images depicting what the driver of the vehicle sees when looking at the 3D HUD; and stream the live video data to the mobile client device to cause the screen of the mobile client device to display the video stream that depicts what the driver of the vehicle sees when looking at the 3D HUD.
US10232706B2 Vehicle automatic transmission axle assembly
An automobile automatic transmission axle assembly: A power input shaft extends into a transmission compartment; the power input shaft in the transmission compartment is provided with a transmission mechanism; the transmission mechanism comprises a transmission sliding sleeve assembly, modified isolators, gear-position sun gears, planet gears, a planet carrier and gear rings; the gear-position sun gears, planet gears and gear rings constitute a mechanism having a fixed transmission ratio; the transmission sliding sleeve assembly fits the modified isolators. The automobile automatic transmission axle assembly realizes an integrated automatic transmission axle for electric vehicle.
US10232697B2 Battery mounting structure for vehicle
A battery mounting structure having an enhanced rigidity against an impact load applied from the side is provided. Battery modules are juxtaposed to form arrays of the battery pack in a battery pack and the battery pack is disposed between the frame members. A load transmission member is disposed in a clearance between the battery modules adjacent to each other in a width direction of the vehicle. The load transmission member is crushed in the width direction by an impact load applied from the side of the vehicle to absorb collision energy.
US10232693B1 Water management for a vehicle
A vehicle can include an A-pillar water management system. The system can include an inner body member of a vehicle. The system can include a channel member operatively connected to the inner body member. A channel can be defined at least partially by the channel member. The channel can open in a substantially vertically upward direction. The channel can have an open first end and a second end. The second end can be opposite the first end. The first end can be located closer to a front end of the vehicle than the second end. A seal, such as an A-pillar to front fender seal, can operatively engage the inner body member. The seal can extend in a substantially vertical direction. The channel can extend in a direction that is transverse to the seal. The channel can pass between the seal and the inner body member.
US10232692B1 Automobile wind directing accessory device
An automobile wind directing accessory device that is attachable to a sunroof opening of an automobile and has a panel or windshield, support bracket secured to a rear surface of the windshield, a support arm rotatably connected to the support bracket and at least one adjustable clamp having a first leg slidably connected to the support arm to enable the clamp to be adjusted inward or outward inside the sunroof opening to dictate the point where the windshield directs wind flow into the cabin of a vehicle and a second leg pivotally connected to the first leg by a spring device that maintains tips of the first leg and second leg in engagement with a vehicle in a normally closed position to secure the wind directing device in a vehicle opening and that are separated and opened when the first leg and second leg of the clamp are squeezed toward each other. The automobile wind directing accessory device is adapted for attached to a vehicle inside a window wherein the clamped is affixed to the support bracket in alignment with the rear surface of the wind shield.
US10232689B2 Vehicular door structure
A vehicular door structure includes a door inner panel in which a work aperture is formed, a sealing sheet configured to close the work aperture, a sealing compound application section formed at the door inner panel, and an attachment member configured to hold a wire-shaped member and attach the wire-shaped member to the door inner panel, wherein the attachment member is disposed in the middle of an extension direction of the sealing compound application section, and a sealing compound configured to adhere the sealing sheet to the door inner panel side is continuously applied across the sealing compound application section and the attachment member.
US10232679B2 Air deflector device of an air conditioning system for an automobile
The invention relates to an air deflector device for an air conditioning system in a motor vehicle. The air deflector device has at least one closure element and at least one air mixing element. The closure element and the air mixing element have a common rotational axis in the air deflector device. The closure element extends in the direction of the rotational axis across the entire depth of a cross-section of a flow passage to be closed off in the air conditioning system, and comprises retaining elements.The air mixing element, which extends in the direction of the rotational axis, is embodied according to the invention with cross-flow openings, so that a cross-section of at least one flow passage of the air conditioning system can be adjusted based on the position of the air deflector device.
US10232677B2 System and method for placing an active suspension system in a demonstration mode
System and method for operating an active suspension system of a vehicle includes actuating a switch on the vehicle, setting the active suspension system for the vehicle to a demonstration mode, setting a timer when the active suspension system is set to the demonstration mode, and setting the active suspension system for the vehicle to a normal operating mode after the timer reaches a predetermined time. Prior to expiration of the timer, the system and method determines a gear in which the vehicle is placed, determines whether an engine of the vehicle is running if the transmission gear of the vehicle is drive, reverse, or neutral, and determines a throttle angle of the vehicle if the engine is running. The active suspension system is set to a normal operating mode if the throttle angle is greater than a predetermined angle. An iterative process determines the status of the timer.
US10232676B2 Gooseneck hitch locking apparatus and system
A gooseneck hitch locking apparatus and system that is safe and reliable, can standup to a large range of weather conditions, and can be activated remotely thereby allowing for the coupling/uncoupling of a trailer to a towing vehicle without requiring a user to climb into/out of the bed of the towing vehicle. A remotely controlled actuator raises and lowers a locking pin through a locking hole of a gooseneck hitch with a force loaded ball hitch locking plate, thereby preventing the locking plate from moving and keeping the coupled ball hitch from uncoupling. A handle connected to the locking pin is connected to the actuator via a fastener. The fastener may be removed, thereby allowing manual operation of the gooseneck hitch locking apparatus and system via the handle, thus allowing the manual coupling or uncoupling of a the trailer from a towing vehicle.
US10232673B1 Tire pressure monitoring with vehicle park-assist
Method and apparatus are disclosed for tire pressure monitoring with vehicle park-assist. An example vehicle includes tires, tire pressure monitoring system (TPMS) sensors, a park-assist controller to determine a parking path, and a TPMS controller. The TPMS controller is to determine tire characteristics based on the parking path, calculate tire indexes for the tires based on the tire characteristics, and select one or more of the TPMS sensors based on the tire indexes. The TPMS controller also is to instruct, via a communication module, the selected TPMS sensors to collect pressure measurements during park-assist.
US10232657B2 Face films and pressure sensitive laminates for printing
Microporous structures in face films are described for improving printability of the films. Also described are laminates and pressure sensitive adhesive laminates including the microporous structured face films. Various related methods are additionally described.
US10232650B2 Method of editing a flatbed print job
A method of editing a print job to be printed on a flatbed printer including a flatbed surface for placing a piece of media to be printed upon, the flatbed surface having a vacuum zone connected to a vacuum source for attracting the piece of media to the flatbed surface, is performed on a job editor including a processor and a display. The processor performs the steps of: reading vacuum zone data specifying at least a size of the vacuum zone; constructing and displaying an image of the vacuum zone on the basis of the vacuum zone data; and superposing, on the display, an image to be printed and the image of the vacuum zone.
US10232648B2 Recording apparatus
A printer includes an encoder scale having a reading region that is read by an encoder that detects a motion of a transport driving roller, and an anti-static unit having an anti-static brush that is in contact with the encoder scale and a base that supports the anti-static brush, wherein the anti-static brush is in contact with a region of the encoder scale other than the reading region.
US10232642B2 Data generation method, computer-readable storage medium, and structure manufacturing method
A first pattern P1 is formed with a first material for converting electromagnetic wave energy into heat energy, on a first surface BS of a print medium M including an expansion layer M2 that expands by heating. A second pattern P2 for expanding the expansion layer M2 to complement expansion of the expansion layer M2 by the first pattern P1 is formed with a second material for converting electromagnetic wave energy into heat energy, on a second surface FS which is an opposite surface of the print mediumM to the first surface BS and is closer to the expansion layer M2 than the first surface BS. The first material forming the first pattern P1 is irradiated with electromagnetic waves from the first surface BS. The second material forming the second pattern P2 is irradiated with electromagnetic waves from the second surface FS.
US10232639B2 Fluid application
Certain examples of apparatus for applying fluid in a printing system are described. The apparatus comprise a first chamber having a first aperture extending along a first axis, and a second chamber having a second aperture extending along a second axis, wherein the first axis is substantially parallel to the second axis. The second chamber is movable with respect to the first chamber. Also, methods for supplying a fluid, and printing systems are described.
US10232635B2 Optical scanning device and image forming apparatus including the same
In an optical scanning device including a vibration mirror part, elastically deformable resin portions are respectively provided at both end portions in a main scanning direction on a surface of the vibration mirror part, which is an opposite surface of a reflective surface, a collision member, which has a collision surface and can collide with each of the resin portion, is provided at a side opposite to a side of the reflective surface of the vibration mirror part, and a control unit allows the vibration mirror part to swing such that each of the resin portion collides with the collision surface at least once before light beam for image data writing is deflected and scanned by the vibration mirror part, and then allows the vibration mirror part to swing in a range in which each of the resin portion does not collide with the collision surface.
US10232632B2 Liquid ejection apparatus and liquid ejection head
An object is to provide a liquid ejection apparatus that allows suppression of a fluctuation in a pressure of a liquid in a flow path caused by a liquid delivery unit, enabling the liquid to be stably ejected through an ejection port. The liquid ejection apparatus including a liquid ejection head having an ejection port through which a liquid is ejected, a flow path configured to communicate with the ejection port, and a liquid delivery unit configured to feed the liquid to the flow path. A relation between an angular frequency ω of the liquid delivered from the liquid delivery unit, a coefficient of kinematic viscosity ν of the liquid, and an equal diameter a of at least a part of a section of an extra-head flow path in a direction normal to a direction in which ink flows satisfies √(ω/2ν)×a>1.
US10232625B2 Ink-jet printer
An ink-jet printer includes a conveyor, a carriage, a recording head, an ink receiver, a command receiver, and a controller. The controller executes: determining an ink amount that the recording head should discharge to the ink receiver; executing a flushing process that moves the carriage to an area facing the ink receiver and causes each of a plurality of nozzles to discharge ink of the determined ink amount; and based on the flushing process having finished, executing a recording process. The controller, based on the determined ink amount being less than a first threshold value, causes the recording head to discharge ink of the determined ink amount in α times of the flushing processes, and based on the determined ink amount being the first threshold value or more, causes the recording head to discharge ink of the determined ink amount dispersed in β(β>α) times of the flushing processes.
US10232624B2 Ink-jet printer
An ink-jet printer includes a conveyor, a recording head, a power supply, an ink receiver, a command receiver, and a controller. The controller executes: determining an ink amount to be discharged; determining a voltage value of a drive voltage and the number of ink droplets; raising the drive voltage; executing a flushing process, executing a printing process. The controller determines the voltage value such that the drive voltage becomes higher when the determined ink amount is not less than a first threshold value than when the determined ink amount is less than the first threshold value, and determines the number of ink droplets such that the number of ink droplets becomes larger when the determined ink amount is not less than a second threshold value than when the determined ink amount is less than the second threshold value.
US10232623B2 Bubbler
A cartridge may include a fluid reservoir, a print head to eject fluid from the reservoir through nozzles and bubblers. The print head may include a fluid feed slot to supply fluid from the reservoir to the nozzles. The bubblers are opposite the fluid feed slot.
US10232620B2 Printhead with s-shaped die
A printhead may include a number of s-shaped dies embedded in a moldable substrate. An medium-wide array may include a number of printheads with each printhead including a number of s-shaped dies and an ejection fluid feed slot to provide a single type of ejection fluid to the s-shaped dies. An s-shaped die of a printhead may include a number of columns of nozzles and an electrical interconnect coupled to a number of firing chambers associated with each of the nozzles, the electrical interconnect positioned adjacent to the number of columns.
US10232615B2 Microfluidic MEMS printing device with piezoelectric actuation
A microfluidic device, having a containment body accommodating a plurality of ejecting elements arranged adjacent to each other. Each ejecting element has a liquid inlet, a containment chamber, a piezoelectric actuator and an ejection nozzle. The piezoelectric actuators of each ejecting element are connected to a control unit configured to generate actuation signals and to be integrated in the containment body.
US10232613B2 Atomic layer deposition passivation for via
In one example, a liquid ejection device. The device includes a first metal layer over a substrate, a dielectric layer over the first metal layer, and an orifice through the dielectric layer to the first metal layer. The device also includes a second metal layer over the dielectric layer and partially filling the orifice to form a via to electrical connect the two metal layers. The via has a depth-to-width ratio of at least 0.4. The device further includes a passivation stack covering the second metal layer including all interior surfaces of the via. The stack includes an ALD-deposited layer formed by atomic layer deposition.
US10232610B2 Fluidic die
A fluidic die includes a number of sensors to measure properties of a number of property control elements associated with the printhead die, a pass gate to communicate a number of signals to an application specific integrated circuit (ASIC) via an analog bus using control logic associated with the pass gate, and a bi-directional configuration bus coupled to the fluidic die to transmit a number of control signals to property control elements located on the fluidic die.
US10232608B2 Droplet ejection control apparatus, droplet ejection control method, and droplet ejection control program
Droplet ejection amounts are adjusted during a process of generating raster data, and this process is realized by a control circuit. The sum total of droplet ejection amounts exceeds 100% as for three nozzles while the sum total of droplet ejection amount is below 100% as for one nozzle, which is repeated at some nozzle numbers. The sum total of droplet ejection amounts is 100% in a normal portion. As such, in the case where this sum total is taken as a reference amount, the sum total of droplet ejection amounts for each raster in a region where overlap printing is performed is sequentially changed to be equal to or greater than the reference amount in the normal region where the overlap printing is not performed, and to be equal to or smaller than the above reference amount.
US10232606B2 Printing device and printing method
A printing device prints an object on a medium by inkjet printing. The printing device includes: a glossy ink head that discharges ink droplets of a glossy ink having a glossy color; and a main scan driver that prompts the glossy ink head to perform main scans in which the glossy ink head discharges the ink droplets while moving in a predetermined main scanning direction. The glossy ink contains a glossy pigment and a solvent. In the main scans, the glossy ink head discharges the ink droplets plural times while moving in the main scanning direction to form ink dots at positions on the medium aligned in the main scanning direction. The ink droplets discharged from the glossy ink head each have a volume constituting a size that allows for contact on the medium between any ones of dots formed in each one of the main scans.
US10232605B2 Method for three-dimensional fabrication with gas injection through carrier
A method of forming a three-dimensional object (17), is carried out by: (a) providing a carrier (18′) and an optically transparent member having a build surface, with the carrier and the build surface defining a build region therebetween; (b) filling the build region with a polymerizable liquid; (c) irradiating the build region with light through the optically transparent member to form a solid polymer from the polymerizable liquid; and (d) advancing the carrier away from the build surface to form the three-dimensional object from the solid polymer; (e) wherein the carrier has at least one channel (32) formed therein, the method further including supplying pressurized gas into the build region through the at least one channel during at least a portion of the filling, irradiating and/or advancing steps. An apparatus for performing the method is also disclosed.
US10232603B2 Three-dimensional printer
A printer (106) for building a three-dimensional model by sequential deposition of a plurality of cross-sectional layers by using a thermal print head (1) movable relative to a material bed (102) over a deposited layer. A protective sheet (3) is disposed between the thermal head (1) and deposited layer. Temperature control of the material bed (102) to prevent warping of the model is provided by an independently heatable cover (52, 58) in contact with the surface of the material bed (102) e.g. via the protective sheet (3).
US10232602B2 Method and apparatus for producing three-dimensional objects with improved properties
Method for fabricating a three-dimensional object by successive consolidation, layer by layer, of selected regions of a layer of powder, consolidated regions corresponding to successive sections of the three-dimensional object, comprising in order: a—deposit layer of powder onto a support; b—fuse the layer of powder by a first laser energy source so as to obtain a fused layer corresponding to the section of the object and exhibiting a first state of its mechanical properties, c—heat at least a part of the fused layer by a second electron beam energy source to a temperature which follows a controlled variation over time so as to modify the first state of the fused layer and to obtain a consolidated layer with improved mechanical properties, d—repeat the preceding steps until several superposed consolidated layers are formed with improved properties forming the object.
US10232601B2 Decoration method of printed matter and printed matter
A decoration method of a printed matter includes: forming a printed layer on a surface of a sheet or of a mounting paper with a transparent varnish, printing a predetermined pattern on the surface of the printed layer by an ink or by a resin which are capable of being adhered to the printed layer; and pressing a metal foil onto the pattern printed by the ink or the resin with an adhesive agent. The adhesive agent does not adhere to the printed layer but adheres to the pattern. As a result, the metal foil 6 is printed only to the pattern.
US10232597B2 Methods of forming a thinned prepreg sheet
A method of forming a thinned prepreg sheet is disclosed. The method comprises providing a first precursor sheet comprising reinforcement fibers impregnated with a matrix resin in a first state. The method also comprises forming a second precursor sheet having a first thickness by cooling the first precursor sheet until the matrix resin is transformed from the first state to a second state. The method further comprises forming a crushed sheet comprising interstices having an average size by crushing the second precursor sheet, where the crushed sheet has a second thickness. The method also comprises forming the thinned prepreg sheet by heating the crushed sheet until the matrix resin is transformed from the second state to a third state. The thinned prepreg sheet has a third thickness less than the first thickness of the second precursor sheet.
US10232592B2 Laminated glass articles
A method for manufacturing laminated glass articles includes the steps of inkjet printing an image with one or more inkjet inks on a first glass sheet; jetting and at least partially curing a curable sealing agent on three edges of the first glass sheet on the side for the inkjet printed image; aligning a second glass sheet with the first glass sheet on the side of the first glass sheet carrying the at least partially cured sealing agent and the inkjet printed image; applying a liquid curable adhesive resin composition into an interspace between the first and second glass sheets; and curing the liquid curable adhesive resin composition until a solid adhesive layer is obtained.
US10232588B2 Siloxane compositions and methods for reducing VOC and siloxane dust
An improved water-resistant gypsum product prepared with a high-viscosity siloxane is provided. A fuel-efficient method for making the product and reducing the amount of siloxane dust released is provided as well.
US10232586B2 Pressure-sensitive adhesive tapes for the adhesive bonding of windows more particularly in mobile equipment
Composite made of two substrates for use for optical, electronic and/or precision-engineered equipment, comprising a first substrate and a second substrate and, arranged so as to connect the first substrate to the second substrate, an adhesive layer, wherein the adhesive layer comprises an adhesive which has, relative to the mixture, (a) from 60% by weight to 90% by weight of a first polymer component based on polyacrylate and (b) from 10% by weight to 40% by weight of a second polymer component based on elastomers, where the second polymer component is essentially not miscible with the first polymer component, so that the adhesive is present in at least two separate phases in the adhesive layer.
US10232584B2 Resin sandwich panel, and method for manufacturing resin sandwich panel
In a resin sandwich panel, the two resin skin material sheets have peripheral edge portions thereof joined to each other so as to form an internal hollow portion. The resin core material is disposed in the hollow portion. At least one of surfaces of the resin core material opposing the two resin skin material sheets has a groove portion extending across the entire surface, and a depression communicating with the groove portion. At least one of the two resin skin material sheets additionally has an atmosphere-opened through-hole provided in a thickness direction thereof. When the one of the surfaces of the resin core material and the corresponding resin skin material sheet are surface-to-surface adhered to each other in the hollow portion, air between the surfaces and the skin material sheet is guided to the depression via the groove portion, and exhausted out of the atmosphere-opened through-hole.
US10232567B2 Device for laying up a composite product with fibrous rovings
Device for laying up a composite product with fibrous rovings made from glass, carbon, aramid and other similar filaments, designed especially for production of composite reinforcements or supporting elements such as the reinforcement of tailgates of personal vehicles, consists of individual unwinding spools (2) of fibrous rovings (21) rotatably arranged around the composite product (1). The unwinding spools (2) are installed on the set of the rotary disc rings (3) which are mounted on a common fixed ring frame (4) and equipped with independent drives (5) with pre-programmed control of direction and speed of their rotation wherein the composite product (1) is during the laying up procedure alternately fixed to individual carrier grippers (8) of at least one program-controlled manipulator (9). In each rotary disc ring (3) as well as in fixed ring frame (4) at least one lateral passage (6) is created for entry and exit of the composite product (1) between the unwinding spools (2).
US10232565B2 Back seam welder and method of operation
A thermal welder is configured to weld a back seam of a bag formed of thermoplastic sheet material. The welder may include a weld heater and a compression mechanism downstream of the weld heater to compress the sheet material to form the back seam. The welder may also include a weld breaker downstream of the compression mechanism to break apart incidental welds which are formed adjacent the back seam.
US10232560B2 Composite structure formed of fiber reinforced plastic sheet and metallic sheet, and manufacturing method thereof
A manufacturing method of a composite structure includes: (a) preparing: a metallic sheet(s) having a through-hole(s) penetrating throughout the metallic sheet(s) in its thickness direction; (b) setting a prepreg(s), constituting a fiber reinforced plastic sheet(s), and the metallic sheet in a pair of dies, which have a recess(es) arranged at a position(s) opposed to one side opening(s) of the through-hole(s), the recess(es) having a larger diameter than the one side opening; (c) closing the dies, wherein, upon closing, (ca) the prepreg(s) and the metallic sheet are molded to the predetermined shape, while surface-contacting therebetween, (cb) at least one of the prepreg(s) and a patch member(s) is extruded into the through-hole(s), so that the shaft part is molded, and (cc) the patch member(s) forms at least part of a head part(s) in the recess(es), the head part(s) integrated with the shaft part(s) and engaging on the metallic sheet(s).
US10232559B2 Composite structural components with reduced coefficient of thermal expansion
A composite structural component includes a longitudinally extending elongated tubular duct of a first material having a first coefficient of thermal expansion, and a plurality of longitudinally extending elongated reinforcing members of a second material. Each of the reinforcing members is secured to the tubular duct along a length of the reinforcing member at spaced apart locations on the tubular duct, with the second material having a second coefficient of thermal expansion less than the first coefficient of thermal expansion, such that the composite structural component has an effective coefficient of thermal expansion in the longitudinal direction that is less than 25% of the first coefficient of thermal expansion. Each of the plurality of reinforcing members is retained in a corresponding one of a plurality of longitudinally extending recesses formed in a peripheral wall of the tubular duct.
US10232554B2 Three-dimensional printing system including three-dimensional printing apparatus and support arrangement determining apparatus
An arrangement determining apparatus includes a center-of-gravity calculating processor that calculates a center of gravity of a three-dimensional model, a placement surface determining processor that determines a placement surface to attach and arranging supports thereon, a reference point setting processor that draws a perpendicular line from the center of gravity toward the placement surface and sets a reference point, a region dividing processor that divides the placement surface into a first region and a second region excluding the first region, and an arranging processor that attaches and arranges the supports on the placement surface so that the contact area per unit area between the first region and the supports in the first region is larger than the contact area per unit area between the second region and the supports in the second region.
US10232552B2 Method for three dimensional printing
A system for printing three dimensional objects using a liquid-matrix support includes a motor, a resin, a stage, oil, and a light projecting source. The motor is an operating interface that is adapted to move the stage in an upward or in a downward direction. The resin in the system comprises a light polymerizable liquid. The light from the light projecting source is projected onto the resin to provide a shape to the three dimensional objects. The stage is adapted to move in the upward or in the downward direction to support the growing layers of the printed three dimensional objects. The oil is a non-aqueous hydrophobic and oleo-phobic component that is coupled at an interface with the resin by a liquid-matrix support which includes an additive. The light projecting irradiates the resin, and, in a preferred embodiment, irradiation passes through the oil to the resin. The liquid-matrix support enhances speed, resolution and provides smooth finishing texture to the printed three dimensional objects of large and small dimensions.
US10232551B2 Head and system for continuously manufacturing composite hollow structure
A head is disclosed for use with a continuous manufacturing system. The head may have a housing, a fiber guide rotatably disposed at least partially inside the housing, and a diverter disposed at an end of the housing. The diverter may be configured to divert radially outward a matrix-coated fiber passing through the fiber guide.
US10232550B2 Systems for additively manufacturing composite parts
A system for additively manufacturing a composite part comprises a delivery assembly, a feed mechanism, and a source of curing energy. The delivery assembly comprises a delivery guide movable relative to a surface and is configured to deposit a continuous flexible line along a print path. The delivery assembly further comprises a first inlet, configured to receive a non-resin component, and a second inlet, configured to receive a photopolymer resin. The delivery assembly applies the photopolymer resin to the non-resin component. The feed mechanism pushes the continuous flexible line out of the delivery guide. The source of the curing energy delivers the curing energy to a portion of the continuous flexible line after it exits the delivery guide.
US10232548B2 Manufacturing method of tank
A manufacturing method of a tank comprises winding a fiber on a liner by hoop winding. The winding comprises: forming an (N+1)-th layer such that a position closer to a center of the liner by a first predetermined distance along an axis line direction of the liner from an end in the axis line direction of an N-th layer is set to position of an end in the axis line direction of the (N+1)-th layer with respect to a direction perpendicular to the axis line direction; and winding the fiber on the N-th layer to provide one winding turn of the fiber, such that a pressing force of pressing the N-th layer in the axis line direction by the fiber is equal to or smaller than a total frictional force in an area in the N-th layer on an edge side in the axis line direction of a fiber winding position.
US10232546B2 Filament winding system
A filament winding system includes a storage unit that stores in advance a reference shape of a winding object, and winding conditions including a winding position and a winding angle at which a fiber is wound around the winding object having the reference shape, a guide that is movable relative to the winding object, and feeds the fiber onto the winding object, a rotating device that rotates the winding object, such that the fiber fed from the guide is wound around the winding object, a measuring unit that measures a shape of the winding object, and a controller. When there is a difference between the reference shape stored in the storage unit, and the measured shape of the winding object, the controller corrects the winding conditions so as to reduce or eliminate the difference, and controls the guide according to the corrected conditions.
US10232544B2 Method of manufacturing a helium-free balloon
The inventive technology encompasses new and novel methods for manufacturing helium-free balloons using improved injection molding systems and techniques. The invention includes new and novel preform, as well as parison based methods and methods of manufacturing integrated helium-free balloons compatible with external support components.
US10232537B2 Interdigitated finger coextrusion device
A co-extrusion device includes at least one first inlet port to receive a first material, at least one second inlet port to receive a second material, a first combining channel arranged to receive the first material and the second material and combine the first and second materials into a first combined flow flowing in a first direction, a splitter channel arranged to receive the first combined flow and to split the first combined flow into at least two split flows in a second direction at least partially orthogonal to the first direction, wherein each split flow consists of the first and second materials, a second combining channel arranged to receive the split flows and combine the split flows into a second combined flow in the first direction, and at least one exit orifice arranged to allow the materials to exit the device as a single flow.
US10232536B2 Molding monitoring apparatus
A molding monitoring apparatus acquires an image of a molding molded by an injection molding machine, determines whether abnormality is present in the molding, and specifies an abnormality occurrence position thereof when the abnormality is present. Further, the molding monitoring apparatus calculates the number of abnormality occurrences for each abnormality occurrence position, and compares, among the calculated number of abnormality occurrences for each abnormality occurrence position, the number of abnormality occurrences for each abnormality occurrence position in a certain term with the number of abnormality occurrences for each abnormality occurrence position in another term.
US10232533B2 Method and thermoplastic foamed article
A method for making a low density foamed article includes placing a desired amount of thermoplastic polyurethane foam beads in a cavity of an injection mold and closing the mold; combining in an extruder connected to the mold a molten polymer selected from the group consisting of thermoplastic polyurethane elastomers and thermoplastic ethylene-vinyl acetate copolymers with both a physical or chemical blowing agent other than a supercritical fluid present in an amount up to about 15 wt % based on molten polymer weight and a supercritical fluid that is at least one of about 0.1 to about 5 weight percent of supercritical CO2 based on molten polymer weight or about 0.1 to about 4 weight percent of supercritical N2 based on molten polymer weight, to form a mixture and injecting the mixture into the mold and foaming the mixture to form the low density foamed article.
US10232532B1 Method for fabricating tapered thermoplastic composite parts
Consolidation tooling is used in a continuous compression molding machine to produce a fiber reinforced thermoplastic part having a varying height. The tooling includes first and second tool dies adapted to compress and form a multi-ply stack of thermoplastic prepreg into a part, and at least a first tooling sleeve movable through the first and second tool dies. The tooling sleeve has at least a first tapered portion engageable with the multi-ply stack.
US10232531B1 Methods and apparatus for forming a polymer layer around a structure using a plurality of protrusions
A method may involve positioning a structure on a plurality of protrusions that extend from a surface of a molding piece, wherein the structure comprises a sensor or an electronic component; forming, using the molding piece, a body-mountable device by forming a polymer layer around the structure positioned on the plurality of protrusions, such that the structure is at least partially enclosed by the polymer layer, wherein the polymer layer defines a first side of the body-mountable device and a second side of the body-mountable device opposite the first side, and wherein the surface of the molding piece supports the polymer layer as the polymer layer is being formed; and removing the body-mountable device from the molding piece.
US10232530B2 Induction heating device and method for making a workpiece using such a device
The invention concerns a device for heating a surface by induction, in particular for molding or transforming a part made of thermoplastic or thermosetting composite material. The device comprises a body having at least one portion made of magnetic and heating conducting material wherein is provided a plurality of closed cavities proximate the surface to be heated, each cavity surrounding a field winding. The heat produced by induction on the walls of the cavity is transferred by conduction to the heating surface. The distance between the cavities and the position of said cavities relative to the heating surface are such that the heating is substantially uniform on said surface.
US10232529B2 Support material and applications thereof
In one aspect, support materials operable for use in 3D printing systems are described herein. In some embodiments, a support material comprises a wax component comprising at least one ethoxylated fatty alcohol and a viscosity modifying agent, wherein the support material is water dispersible. In some embodiments, the wax component comprises a mixture of at least one fatty alcohol and at least one ethoxylated fatty alcohol.
US10232526B2 Device and method for casting concrete objects
The invention relates to a device and a method wherein a product mold is placed in a basin. The product mold is filled with wet concrete and an intermediate space between the product mold and the basin is filled with a non-hardening slurry having a density substantially similar to the density of the wet concrete. During the filling, the level difference between the wet concrete surface level and the non-hardening slurry surface level is controlled such that the pressure of the wet concrete on the inside of an outer wall of the form mold is substantially balanced by the pressure of the slurry on the outside of the outer wall of the form mold. The invention thus enables the use of a product mold that differs from traditional form works in that its outer wall does not need to support the pressure of the wet concrete contained within the product cavity.
US10232520B2 Primary alkaline battery
A primary battery includes a cathode having a non-stoichiometric metal oxide including transition metals Ni, Mn, Co, or a combination of metal atoms, an alkali metal, and hydrogen; an anode; a separator between the cathode and the anode; and an alkaline electrolyte.
US10232518B2 Robot pivot shaft structure
Provided is a robot pivot shaft structure that includes a revolving drum rotatably supported at an upper portion of a base and that has a hollow portion, a drive motor rotating the revolving drum, and a speed reduction mechanism reducing the rotational speed of the drive motor. The speed reduction mechanism has a small gear fixed to a shaft of the drive motor, a large gear meshed with the small gear, an input hypoid gear fixed to the large gear, and an output hypoid gear meshed with the input hypoid gear. The output hypoid gear is fixed to the revolving drum and is disposed in the base. The input hypoid gear and the large gear are rotatably supported at the base. The drive motor is fixed to the base and disposed below the revolving drum, the position being horizontally shifted from vertically below the hollow portion.
US10232516B2 Gripper assembly and method for gripping a tire component
A gripper assembly has a gripper having a gripping element with a gripping face to engage and retain a tire component through suction. The gripping face has a plurality of sections; each section has a vacuum channel and a valve placed between the vacuum channel of the respective section and a vacuum source. Each valve is individually operable to an open position and a closed position, wherein the gripping face in use has a suction area formed by the sections of which the respective valves are in the open position, wherein the suction area is adjustable by selectively operating the plurality of valves to open positions and closed positions wherein the gripper assembly further has a configuration tool which is arranged to control the respective valves to their open and closed positions.
US10232514B2 Point of control remote-actuation apparatus and methods
Apparatus and methods for remote (at a distance) actuation of points of control, such as valves and switches. Controlling a switch or valve at a distance is achieved by a support member having a movable portion, with the moveable portion including an elongate member, and a drive mechanism in communication with the moveable portion. A motor, hand crank, or other force transmission apparatus acts to move the drive mechanism and thus the movable portion and elongate member such that a valve or switch is actuated at a distance.
US10232511B2 Method for calibrating a measuring apparatus for measuring body parts and other workpieces, and measuring apparatus suitable for carrying out the method
A measuring apparatus comprises an industrial robot and a sensor fastened to a movable arm of the robot. A calibration body comprises a calibration element, a carrier, and an alignment element rigidly arranged relative to the carrier. The alignment element interacts with a counter piece provided on a carrying structure. Data specifying the pose of the calibration element relative to the alignment element are encoded in an encoding zone which may be embodied as a data matrix code. The calibration body is initially aligned on the carrying structure with the aid of the alignment element and the counter piece. The sensor then approaches the encoding zone to read the data encoded therein. Subsequently, the pose of the calibration element relative to the carrying structure is determined using the previously read data. Finally, the pose of the calibration element is measured by the sensor to calibrate the measuring apparatus.
US10232510B2 Robot control
A method for controlling a mechanical system having a plurality of components interlinked by a plurality of driven joints, the method comprising: measuring torques or forces about or at the driven joints and forming a load signal representing the measured torques or forces; receiving a motion demand signal representing a desired state of the system; implementing an impedance control algorithm in dependence on the motion demand signal and the load signal to form a target signal indicating a target configuration for each of the driven joints; measuring the configuration of each of the driven joints and forming a state signal representing the measured configurations; and forming a set of drive signals for the joints by, for each joint, comparing the target configuration of that joint as indicated by the target signal to the measured configuration of that joint as indicated by the state signal.
US10232502B2 Power equipment cooling system
A method of cooling blower components may include rotating a fan assembly (160) responsive to operation of a motor (120). The rotation of the fan assembly may create an underpressure region in an inlet portion (154) and an overpressure region at a main channel (340) of the fan assembly (160). The method may further include drawing air into the inlet portion (154) through a control unit housing portion (132) of a housing (110) of the blower (100) to cool a control unit (130) of the blower (100), drawing air into the inlet portion (154) through a battery compartment (142) to cool a battery (140) of the blower (100), and pushing air from the main channel (340) through a motor housing (320) to cool the motor (120).
US10232500B2 Impact machine
The invention relates to an impact machine (100, 200) which is adapted to perform a hammering operation on a surface or an object to be worked upon.In particular, a vibration reduction arrangement (140, 240) is attached to the housing (105, 205, 305, 405) and comprises a movable counterweight, interacting with a motion reversing arrangement having a non-linear spring characteristics, such that the motion of the counterweight can be brought into a counter-acting movement in relation to the vibrations in the housing (105, 205, 305, 405) of the hammering element (110, 210, 310, 410) thus substantially reducing the vibrations.
US10232499B2 Production method for a tool socket
A production method for a tool socket includes forming a hollow spindle An elongated recess is provided in the wall. The spindle includes unalloyed or low-alloyed steel grades. An insert includes a high-alloyed tool steel. The insert has a pedestal that is complementary to the recess and it also has a rib. The insert is placed into the hollow spindle in such a way that the pedestal rests in the recess and the rib projects into the interior of the spindle. The pedestal is soldered into the recess at a temperature that is above the Ac3 temperatures of the steel grades employed. The combined structure is cooled and then undergoes a heat treatment in an atmosphere containing sufficient carbon to carburize the hollow spindle but not sufficient to carburize the insert. The heat treatment of the combined structure is carried out at a temperature between 800° C. and 950° C. The combined structure is cooled down in a salt bath or liquid bath subsequent to the heat treatment.
US10232497B2 Power tool for tightening a fastener and a method
A power tool for tightening a fastener includes: an angle measurement unit for measuring a rotational angle (α) of the fastener; a torque measurement unit for measuring a torque (T) delivered to the fastener during tightening; a motor connected to rotatable parts of the power tool for driving the tightening of the fastener; a processor for calculating a tightening energy (Et) needed to complete tightening of the fastener from α to a predetermined target angle (αt), wherein Et is calculated based on α, αt and a stiffness (k) of a joint; and a regulator to regulate a rotational speed (ω) of the motor to provide rotational energy (Er) in the form of rotational inertia in the rotatable parts of the power tool to meet the needed Et, wherein the power tool interrupts the tightening of the fastener at αt, αt defined from snug, at a snug angle (α0).
US10232495B2 Electric ratchet wrench
An electric ratchet wrench includes a driving member rotatably mounted in a body. A pawl device is pivotably mounted to the driving member. A ring gear is rotatably mounted around the driving member. An elastic device is mounted between the ring gear and the driving member. A transmission shaft includes a first end connected to a motor and a second end configured to switch between a meshing state meshed with the ring gear and a disengagement state disengaging from the ring gear. The motor drives the transmission shaft to rotate the driving member. The body can be manually driven to overcome a resistance which is larger than the torque outputted by the motor and which causes a tooth slippage phenomenon between the transmission shaft and the ring gear.
US10232494B2 Ratchet wrench
A ratchet wrench includes a body with a ratchet wheel, a pawl and a switch unit connected thereto. The pawl has a toothed portion on the front side thereof, and a concaved area in the rear side thereof. A first face and two second faces are defined in the concaved area. The first face is located between the two second faces. Each of two sidewalls of the concaved area has a third face. An engaging recess is defined between the second and third faces on the same side relative to the first face. The switch unit controls the pawl to move to engage the toothed portion of the pawl with the ratchet portion of the ratchet wheel so as to control the rotational operations of the ratchet wrench.
US10232491B2 Retruing of a grinding wheel using EDM machine
A process for retruing a profile in an abrasive wheel is provided. A lathe table including an edged cutting tool is used for fixturing a grinding wheel having an outside metal edge and an abrasive matrix adjacent thereto for rotation along an axis compatible for lathe removal of material at at least the outside edge of said wheel. A predetermined amount of material along said edge with the edged lathe cutting tool is removed using the lathe cutting tool. A rotating electrical discharge profiling tool which is attached to an electrical discharge machine is used for profiling of the wheel by electrical discharge machining of the abrasive surface with the rotating electrode. The process uses a machine specifically designed for electrical discharge machining of the profile. The machine also has a mechanism cutting a predetermined profile into the electrode without removing it from the machine.
US10232487B2 Method and apparatus for trimming photovoltaic modules
An apparatus and a method for trimming a module are disclosed. In and embodiment the method includes fixing a rear transverse side of module, guiding the rear cutting head along the rear transverse side thereby cutting off a rear overlapping portion of the overlapping film and releasing the rear transverse. The method further includes moving the module into a region of two longitudinal cutting devices, fixing the module on both longitudinal sides, guiding longitudinal cutting heads along the longitudinal sides thereby cutting off longitudinally overlapping film portions on both longitudinal sides, and releasing the longitudinal sides of the module. The method furthermore includes moving the module into a region of the front cutting device, fixing a front transverse side of the module, guiding a front cutting head along the front transverse side thereby cutting off a front overlapping portion of the overlapping film.
US10232484B2 Method and device for simultaneous centreless cylindrical grinding of multiple workpieces
A method and device for simultaneous centerless cylindrical grinding of multiple workpieces (11, 12, 13, 14), at least sections of which are rotationally symmetrical, the workpieces are arranged on a support apparatus (200) one behind the other between at least one grinding wheel (110) and at least one regulating wheel (120), and wherein the axis of rotation of the regulating wheel is inclined with respect to a horizontal plane extending parallel to the workpiece axes of rotation and the grinding wheel axis of rotation by an inclination angle (α). During grinding the workpieces are arranged with a height offset relative to each other corresponding to at least a quarter of the inclination angle (α) of the axis of rotation of the regulating wheel with respect to the parallel plane to render the respective bearing angles (γ) of the workpieces on the inclined regulating wheel consistent.
US10232482B2 Work seating detection device and adjustment method for same
A work seating detection device including a detection hole formed to discharge air from a work seating face of a chuck, a detection flow path connecting an air supply source supplying compressed air and the detection hole, a pressure switch detecting a secondary-side pressure of a throttle portion formed in the detection flow path, and a pressure regulator adjusting the secondary-side pressure is provided. An adjustment flow path branching on a secondary side of the throttle portion is formed in the detection flow path, an on-off valve is disposed at the adjustment flow path, an adjustment block provided with an adjustment face pressing an adjustment gauge is integrally formed in a tip portion, and an adjustment hole having the same size as the detection hole and communicating with the adjustment flow path is formed in the adjustment block for an opening portion to be positioned in the adjustment face.
US10232480B2 Numerical controller of machine tool
A controller of a machine tool capable of suppressing heat generation and realizing a stable cutting operation during deep cutting is provided. A numerical controller for controlling a machine tool including a spindle motor formed of an induction motor and a feed axis driving motor includes: a magnetic flux amount acquisition means that acquires a present magnetic flux amount of the spindle motor; and a speed change means that changes a speed of the feed axis driving motor on the basis of the magnetic flux amount.
US10232479B2 Power tool including a battery pack isolation system
A power tool includes a housing, a motor positioned substantially within the housing, a drive mechanism supported by the housing and coupled to the motor, a battery pack electrically coupled to the motor, and an isolation system. The isolation system includes an interface member positioned substantially within the housing. The interface member receives a portion of the battery pack to electrically couple the battery pack to the motor. The isolation system also includes a plurality of isolators coupled between the housing and the interface member to isolate the battery pack from the housing during operation of the power tool.
US10232478B2 Tool magazine device and machine tool
A tool magazine device includes a rail that is annularly formed and that has a separation section at a part in a circumferential direction of the rail and a holding ring that is arranged coaxially with the rail and that is rotated by a driving motor. The holding ring is provided with a plurality of holding sections that are open in an axial direction of the holding ring. The holding sections are arranged in the circumferential direction of the holding ring. A tool pot is held to be insertable into and extractable from each holding section. A conveyance unit sends out the tool pot placed in the holding section to an exchange position and sends the tool pot into the holding section from the exchange position. A roller supported by each tool pot rolls on the rail in response to the rotation of the holding ring.
US10232475B2 Device for automatically mounting screw and automatically mounting system
The invention discloses a device for automatically assembling screw and an automatically assembling system, the device includes a frame, a locating member, a taking member, a driving member and a screw feeding member: the locating member is for locating a product to special position; the taking member includes a rotating plate, at least three sucking elements fixed below the rotating member and located at a same circumference, and an electric screwdriver connected with the driving member and located upon the circumference; the driving member drives the rotating plate rotating, the electric screwdriver is movably located on the driving member; the screw feeding member includes a feeding plate including feeding positions, each feeding position corresponds to one sucking element; the driving member drives the sucking element acquiring the screw, and drives the sucking element moving the acquired screw to a position for the electric screwdriver assembling the screw to the product.
US10232470B2 Temporal pulse shaping for laser shock peening
Methods, systems, and apparatuses are disclosed for temporal pulse shaping of laser pulses used in laser shock peening applications. In one embodiment, a system for temporal pulse shaping of a laser beam used for laser shock peening comprises a laser; a modulator; a high voltage driver, a waveform generator, a polarizer, and an optical amplifier.
US10232469B2 System and method for manufacturing component
A method of manufacturing a component is disclosed. The method includes depositing a material on a removable form structure having geometry corresponding to an internal space of the component. The material is deposited on the removable form structure by an additive manufacturing technique. The method includes removing the removable form structure to obtain a pre-machined component, and then machining the pre-machined component to manufacture the component having the internal space.
US10232463B2 Tool and method for bonding layers of a metallic axisymmetric structure having complex curvatures
A tool and method for bonding layers of a shell by the differential pressure bonding process. The tool and method includes a plurality of separable mandrel segments that combine to form a mandrel having a longitudinal axis, an outer surface, an upper end, and at least one substantially continuous inner surface. The inner surface has a substantially axisymmetric shape having complex curvature. In this embodiment, the tool further includes a retort configured to at least partially shroud the outer surface and upper end of the hollow body. The retort includes at least one vacuum port. The tool is configured to facilitate the compression of a plurality of layers of a multi-layer shell having complex curvature as the shell layers and an interdisposed bonding material are heated to an elevated bonding temperature.
US10232462B2 Spot welding
A system for spot welding two metal sheets together includes a plurality of conductive particles placed in an interface between the two metal sheets, a first electrode, and a second electrode. The first electrode and the second electrode are arranged to clamp the two metal sheets together such that the conductive particles become embedded into the metal sheets at the interface between the metal sheets. A conductive path is formed from the first electrode to the second electrode through the metal sheets and the plurality of metallic particles.
US10232461B2 Method for producing a composite component
A method for producing a composite component includes providing a first component with a plastic layer, providing a second component which is formed at least partially from metal, and connecting the first component to the second component to form the composite component. At least one connecting element made of metal is positively connected to the first component and electrical resistance welding to the second component so that between the connecting element and the second component a welded connection is produced.
US10232460B2 Center pipe for plasma torch, contact piece, electrode, and plasma torch
A center pipe is used in a plasma torch for plasma cutting including a base portion and an electrode. The center pipe is inserted into the electrode and supplies cooling water into the electrode. The center pipe includes a pipe body and a contact piece. The pipe body is electrically connected to an electrical power source outside of the plasma torch via the base portion. The pipe body includes a cooling water channel therein. The pipe body is formed with an electrically conductive body. The contact piece is provided on the external circumferential surface of the pipe body and energizes the electrode through contact with the internal circumferential surface of the electrode. The contact piece has elasticity to produce a counterforce when pressed in the radial direction of the pipe body. The contact piece is formed with an electrically conductive body.
US10232455B2 Welded, laminated apparatus, methods of making, and methods of using the apparatus
The invention describes methods of welding onto laminated devices using a low temperature welding process. Also described are laminated devices with welds that do not disrupt a brazed core block of sheets in the laminated devices. Novel laminated devices with welded features for servicing the devices are also described.
US10232453B2 Battery plate cutter system and method
A system, apparatus and method for cutting battery grids or plates from a continuous strip of a plurality of connected battery grids. The continuous strip moves toward a rotating cutter with at least two cutter blades with cutting edges equally circumferentially spaced apart and extending parallel to the cutter axis of rotation and a rotating cooperating anvil. The cutting edges and the anvil are rotated at the same tangential speed to cut in a nip between them a plate or grid from the continuous strip of connected grids. At a point upstream of the cutter, an electric signal indicative of each lug of the grid of the continuous strip moving past this point is used to control the speed of movement of the strip through the nip to cut a plate or grid from the continuous strip at a longitudinal speed which is essentially the same as the tangential speed of the cutting edges.
US10232450B1 Hole saw with properties to allow for easy removal of sawed-off materials
A hole saw, including a rotatable drill bit, a plurality of rotatable saw jaws disposed around the drill bit to encase at least a portion of the drill bit therewithin when the rotatable saw jaws are in a closed position, a fixed locking collar portion disposed at base ends of the plurality of rotatable saw jaws, and a movable locking collar portion to move with respect to the fixed locking collar portion, such that the plurality of rotatable saw jaws pivot away from each other into an open position as the movable locking collar portion moves away from the fixed locking collar portion.
US10232447B2 Drilling machine and method of manufacturing drilled product
According to one implementation, a drilling machine includes a drilling structure and a travelling machine. The drilling structure drills an object to be drilled composed of at least one structural object on a platy part. The travelling machine positions the drilling structure in a travelling direction of the travelling machine by travelling in a longitudinal direction of the at least one structural object using the at least one structural object as a guide.
US10232442B2 Method of making machine component with aluminum alloy under temperature-limited forming conditions
A method of making a machine component includes extruding a supply of an aluminum alloy to produce an extrusion. The extrusion is formed under temperature-limited forming conditions of 275° C. or less to produce a blank. The blank is machined to at least one predetermined tolerance to produce the machine component.
US10232441B2 Fabrication of articles from nanowires
A method of fabricating an article includes providing an arrangement of loose nanowires, forming the loose nanowires into a gas turbine engine airfoil by depositing the loose nanowires into a mold that has a geometry of the gas turbine engine airfoil, and bonding the loose nanowires together into a unitary cellular structure that has the geometry of the gas turbine engine airfoil.
US10232437B1 Method and system of metallic part fabrication
A method of metallic part fabrication includes loose metal powder spread over an additive manufacturing build tank. A fluid binder/ceramic agent solution is selectively deposited upon a predetermined portion of the loose metal powder to create a printed layer. The printed layer is dried to remove a portion of the fluid binder/ceramic agent solution from the printed layer, to create a dried layer. A plurality of dried layers is stacked longitudinally to create a green part. The green part is bulk sintered to create a metallic part with uniformly dispersed and distributed ceramic particles in the metal matrix. A system for metallic part fabrication is also provided.
US10232430B2 Mould material mixture having improved flowability
The invention relates to a mold material mixture for producing casting molds for metal processing, a process for producing casting molds, casting molds which can be obtained by the process and their use. The production of the casting molds is carried out using a refractory base molding material and a binder based on water glass. A proportion of a particulate metal oxide selected from the group consisting of silicon dioxide, aluminium oxide, titanium oxide and zinc oxide is added to the binder, with particular preference being given to using synthetic amorphous silicon dioxide. The mold material mixture contains a surface-active material as further significant constituent. The addition of the surface-active material enables the flowability of the mold material mixture to be improved, which makes it possible to produce casting molds having a very complicated geometry.
US10232428B2 Blind track bolt with higher clamp-up strength
A blind tack fastener includes a pull stem having an elongated shaft with an extended tail portion. The blind tack fastener also includes a crush-initiating washer, a crush sleeve, and a swage collar, surrounding the elongated shaft of the pull stem. The elongated shaft has a breakaway groove configured to create a predictive fracture point below the head-end surface of the swage collar, such that a hole in the swage collar serves as a centering lead-in for a drill that can be used to remove the blind tack fastener.
US10232423B2 Marking method, marking tool, and punch press machine
In a method for marking on a surface of a work, kept is a state where an end of a rotating tool for marking is contacted with a surface of the work, and a rotation of the rotating tool is started at the same time when a relative movement of the work in an X-axis direction and/or in a Y-axis direction relative to the rotating tool is started. According to the above marking method, a width of a marked line can be made constant over its entire length.
US10232421B2 Method of producing inner spiral grooved tube and apparatus for producing inner spiral grooved tube
A method produces an inner spiral grooved tube using a first drawing die, a second drawing die, and a revolving flyer. The method includes two twisting-drawing steps. The first twisting-drawing step forms an intermediate twisted tube by reducing the diameter of a linear grooved tube, which has plural straight grooves formed along the longitudinal direction on its inner surface, by passing the linear grooved tube through the first drawing die and then by revolving the liner grooved tube wrapped around the revolving flyer with the revolving flyer, in conjunction with imparting twist to the linear grooved tube. The second twisting-drawing step forms the inner spiral grooved tube by reducing the diameter of the intermediate twisted tube by passing the intermediate twisted tube, which revolves with the revolving flyer, through the second drawing die in conjunction with imparting twist to the intermediate twisted tube.
US10232420B2 Method for determining the stamping quality of profiled bar material
A method for determining the stamping quality of profiled bar includes steps of: a) upstream of the rolling stand performing shaping, the initial speed VA of the starting product is determined and the initial diameter DA or initial cross-sectional area FA are determined contactlessly. b) After the rolling stand, the final speed VE of the end product is measured and the diameter DE or area FE of a virtual enveloping shell for the end product is determined contactlessly. c) The diameter DN of a virtual, round end product is determined contactlessly as DN=square root of (DA2*VA/VE) and/or the average cross-sectional area FNE of the end product (2) is determined contactlessly as FNE=FA*VA/VE. d1) The characteristic stamping variable PKG is calculated, and the characteristic stamping variable PKG is compared with a pre-set setpoint value PKGset. A device for carrying out the method is also provided.
US10232419B2 Motor speed control device for rolling mill
A motor speed control device for a rolling mill, which includes a rolling roll that rolls a metal material, a roll rotation shaft directly connected to the rolling roll, a motor rotation shaft that transmits power to the roll rotation shaft, and a motor that drives the motor rotation shaft, includes: a non-contact type speed sensor arranged at a position close to the rolling roll with spacing to a circumferential surface of the roll rotation shaft to detect a roll rotation shaft angular speed of the roll rotation shaft; and a speed controller that controls a speed of the motor based on a comparison value between an actual value and a target angular speed of the rolling roll so that the actual value coincides with the target angular speed. The actual value is the roll rotation shaft angular speed to be fed back to the speed controller.
US10232418B2 Method for producing seamless metal pipe
A solid billet is piercing-rolled using a 4 roll-type inclined rolling mill including larger-diameter cone-type main rolls arranged horizontally or vertically to face each other across a pass line and smaller-diameter auxiliary rolls arranged vertically or horizontally to face each other similarly across the pass line between the facing main rolls, while maintaining a feed angle β and cross angle γ of the main rolls and a feed angle β′ and cross angle γ′ of the auxiliary rolls to be within the ranges: 5°≤“β, β′”≤25°; 3°≤“γ, γ′”≤35°; and 10°≤“β+γ, β′+γ′”≤55°.
US10232417B1 Recycling method and apparatus for soil contaminated with mercury and dioxin
The present disclosure provides a method for recycling soil contaminated with mercury and dioxin. The method includes: desorbing mercury and dioxin from the contaminated soil by an indirect rotary furnace; condensing the mercury and discharging it by a condensing and discharging unit; and a secondary indirect burner for decomposing dioxin at a high temperature, so as for the concentration of the contaminants in the exhaust being examined to meet regulation standards and the treated soil to meet the current regulations. The present disclosure also provides an apparatus for recycling contaminated soil containing mercury and dioxin.
US10232406B2 Magnetically secured screen assembly for a conveyor
A magnetically retained screen assembly for a conveyor for processing goods is disclosed. The magnetically retained screen assembly includes one or more magnetic screens and one or more magnet assemblies, wherein the one or more magnet assemblies are configured to magnetically retain the one or more magnetic screens within the conveyor support structure.
US10232405B2 Method for coating a substrate with a lacquer and device for planarising a lacquer layer
A method for coating a substrate with a lacquer is disclosed. First, the lacquer is uniformly applied to the substrate. Then, the solvent proportion of the lacquer applied to the substrate is reduced, and the coated substrate is exposed to a solvent atmosphere. In some embodiments, the lacquer is heated. The invention also relates to a device for planarizing a lacquer layer.
US10232403B1 Spreading tool having a variable width and variable depth blade
A spreading tool has blade for which the width and depth deployment of the blade are each variable. A pair of plates sandwich the blade between them and allow the blade to slide up and down therebetween in order to vary depth deployment. The blade is formed from two plates that each has a blade edge, the two plates slide with respect to each other, varying the overlap of the two blade edges and thus blade width. Slots on each plate with a connector passing therethrough, hold the blade plates together. Aligned slot pairs on the sandwiching plates receive a connector to hold the blade in its sandwiched position, each connector slides within its slot pair and abuts one of the sides of the blade to hold the blade in its selected width. Additional connectors connect the main plate and press plate without passing through the blade.
US10232402B2 Piston driven one shot grease dispenser
The device and method are for one shot greasing of tractor trailer fifth wheels and other structures. The device has an upper tube and a lower tube where the upper tube acts as a piston to push down on the lower tube to dispense a grease supply. The lower tube bottom, or a bottom cap connected thereto, has a plurality of dispensing orifices. Preferred embodiments include a stop mechanism to prevent relative movement of the upper tube and lower tube prior to dispensing, and a removable seal on the bottom that prevents grease release until the seal is removed.
US10232401B2 System for coating a stent
A systems and method for reducing coating defects on a stent may involve a support apparatus comprising wire cage for carrying a stent. The support apparatus may have no structure that extends inside the stent. A support apparatus may include a plurality of wires that pass through the stent but do not pass through the midplane of the stent. A support apparatus may contact only the proximal ends of the stent. The method may involve keeping the stent in motion during a spray coating process to prevent the stent from having a point remain in continuous contact with a support apparatus.
US10232399B2 Slot coater having fluid control unit
Disclosed is a slot coater, which includes a feeding unit having a passage through which a coating fluid flows in, a manifold for accommodating the coating fluid supplied through the feeding unit, a discharge unit communicating with the manifold to discharge the coating fluid accommodated in the manifold, a plurality of shim plates arranged at regular intervals in a length direction of the manifold, and a temperature control unit for generating a temperature difference between a shim plate located relatively closer to the feeding unit and a shim plate located respectively farther from the feeding unit.
US10232397B2 Apparatus for masking a nut plate during painting of an aircraft part containing the nut plate
Apparatus (42) for masking a nut plate (4) during painting of an aircraft part (6) containing the nut plate (4), comprising: (i) a masking formation (8) which is made of a rigid plastics material; (ii) a bore (10) which extends axially through the masking formation (8); and (iii) a mandrel (12) which is made of a flexible material and which extends through the bore (10) and projects beyond the masking formation (8), and the apparatus (42) being such that the masking formation (8) comprises a body portion (14), a masking portion (16), and a skirt portion (20); there are no supporting formations which extend between the body portion (14) and a face (30) of the masking portion (16) and which would act to provide unwanted masking of areas of parts of the aircraft being painted; and the body portion (14) and/or the masking portion (16) are provided with internal integral reinforcing.
US10232394B2 Device for distributing a liquid particularly a cosmetic liquid
A device for distributing a liquid. The device includes a bottle including a reservoir designed to store liquid, and a distribution element, and a concealment assembly. The distribution element allows the liquid to be distributed from the inside to the outside of the reservoir. The concealment assembly includes a base and a concealment ring that is movable along a main displacement axis from a first, operating position, to a second, locking position. The displacement of the concealment ring occurs through a helical movement of the concealment ring relative to the base in relation to the main displacement axis. As well, the displacement of the concealment ring from the operating position to the locking position allows at least part of the distribution element to be concealed. Finally, the concealment element further includes a ballast rigidly connected to the concealment ring.
US10232391B2 Dispensing attachment for a shower head
A dispensing attachment for a shower head 1 has an attachment means 2, 3, 4 configured to allow the dispensing attachment 1 to be removably and repeatably connected to and disconnected from a shower head in normal use without modification of the shower head; a product container 6 configured to hold a quantity of body product in use, the product container 6 comprising a water receiving aperture 7, a main body 8 within which body product is located in use, and a plurality of outlet apertures 9, the attachment means 2, 3, 4 and product container 6 further configured so that when connected to a shower head, the water receiving aperture 7 will receive at least some of the water stream from the shower head, the water stream passing through the product container 6 to intermix with the contents therein and then pass through the outlet apertures 9.
US10232389B1 Fluid delivery system for collected rainwater
A fluid delivery system utilizes Bernoulli pressure differentials and kinetic forces is provided. The system includes a pressurized channel in fluid communication with a flexible pressurized line for translating pressurized fluids to a mixing chamber. The mixing chamber is also in fluid communication with a source channel receiving fluids from a flexible source line. The mixing chamber is configured for entraining the source fluids with the pressurized fluids 26 using Bernoulli principles. Kinetic valves may be used in conjunction with, or in lieu of, the Bernoulli siphoning.
US10232388B2 Multiple orientation rotatable sprinkler
A rotatable sprinkler including a water outlet nozzle providing a pressurized axial stream of water along a nozzle axis, and a rotatable water deflector assembly, downstream of the water outlet nozzle and receiving the pressurized axial stream of water therefrom, the rotatable water deflector assembly being rotated during sprinkler operation by the pressurized axial stream of water about a rotatable water path deflector assembly axis, the rotatable water deflector assembly including a first rotatable water path deflector portion and a second rotatable water path deflector portion, which is user rotatable relative to the first rotatable water path deflector portion about a second rotatable water path deflector axis, thereby enabling user selection of at least one water distribution parameter.
US10232386B1 User-friendly water discharge device with pause structure
A user-friendly water discharge device with a pause structure includes a valve body, a valve core front cover, a gasket, a push block, a magnet, an iron push rod, and a button. The valve core front cover has a water inlet chamber and an inner chamber. The water inlet chamber is provided with a drain hole. The button is pressed and cooperates with a magnetic structure to close or open a through hole of the gasket to achieve a pause function, such that the water can only slightly flow out from the drain hole. It is convenient for operation. The button may be pressed again to open the waterway. There is no need to spend time in re-adjusting the temperature of the water.
US10232376B2 Pipette travel limiting apparatus
An apparatus for limiting pipette head travel with respect to a ground surface, and for limiting insertion of a pipette into a tube, has a top surface including at least one aperture. Each aperture selectively and concurrently accepts a corresponding pipette head of a pipette device therethrough. A bottom surface extends substantially parallel to the top surface and selectively contacts the ground surface. A plurality of side surfaces extends transversely between the top and bottom surfaces. The side surfaces each have a predetermined height correlated with a desired minimum approach distance of each pipette head toward the ground surface. The top, bottom, and side surfaces collectively enclose and define a spacer volume, at least partially through which each pipette corresponding to a pipette head extends. Methods of limiting pipette head travel with respect to a ground surface, and of limiting insertion of a pipette into a tube, are also provided.
US10232375B2 Support device for a sample material container for centrifugation
The invention relates to a support device (14) for supporting a bag (20) containing material to be centrifuged in a centrifuge receptacle (12), said support device (14) comprising a resiliently elastic panel (16) which—when bent—will generate a restoring force, said panel (16) being of a material and a size which will allow it to be bent elastically at least to such an extent that its two ends will contact one another.
US10232374B2 Method of processing dried samples using digital microfluidic device
Methods are provided for the preparation of a sample using a digital microfluidic platform and the optional subsequent mass analysis of an extracted analyte. A sample is dried, optionally on a solid phase support, and contacted with digital microfluidic array. An analyte present within the dried sample is extracted into an extraction solvent by electrically addressing the digital microfluidic array to transport a droplet of extraction solvent to the dried sample spot. The extracted sample may be dried and subsequently processed on the digital microfluidic array for derivatization. The digital microfluidic device may further include an integrated microfluidic channel having an output aperture, and the method may further include contacting a droplet containing extracted analyte with the microfluidic channel and applying a suitable electric field for generating nano-electrospray, thereby enabling the device to be directly interfaced with a mass analysis device.
US10232372B2 Integrated nanofluidic arrays for high capacity colloid separation
A technique relates to an integrated nanofluidic device. A loading layer includes an inlet channel reservoir, a diverted fraction reservoir, and a passed fraction reservoir. A sorting layer is attached to the loading layer such that fluid is permitted to communicate between the loading and sorting layers, where the sorting layer includes a bank of sorting elements. The sorting layer has inlet channels and outlet channels connected to the sorting elements, and the inlet channel reservoir is connected to the inlet channels by an inlet feed hole. The diverted fraction reservoir is connected to the outlet channels by a diverted fraction outlet feed hole, and the passed fraction reservoir is connected to the sorting elements by passed fraction feed holes. The passed fraction feed holes are respectively connected to the sorting elements.
US10232365B2 Test device and sample carrier
A test device (80) for testing for the presence of a substance in a sample held on a sample carrier (30) includes a holder (82) for holding a sample carrier (30) which includes one or more chambers (50,52). The test device (80) also includes an actuator for compressing or depressurizing the chamber(s) (50,52). The actuator is configured to prevent reinflation of the chamber(s) (50,52) after compression or depressurization.
US10232364B2 Aspiration tip
An aspiration tip is provided with: a syringe section including an inner tubular passage defining an aspiration path for aspirating an object; and a plunger movable in the tubular passage while coming in contact with an inner wall surface of the tubular passage. The syringe section includes an aspiration opening formed in a distal end of the tubular passage for aspirating the object, and the plunger includes a plunger leading end portion configured to protrude from the aspiration opening before the aspiration of the object and at the time of discharge of the object, and retract in the syringe section at the time of the aspiration of the object.
US10232363B2 Safety cabinet
A safety cabinet has a second operation chamber in a first operation chamber and into which clean air is supplied, a second suction opening for sucking in air in the second operation chamber and a portion of the air in the first operation chamber, and a second operation opening part that is provided facing a first operation opening part and communicates the second operation chamber with the first operation chamber. Airflow containment (air barrier) is doubled with respect to the outside of a safety cabinet. In cases where decontamination and disinfection operations are carried out according to the changeover procedures, intensive decontamination and disinfection of the second operation chamber is sufficient, and decontamination and disinfection of the first operation chamber is hardly required. Decontamination and disinfection operations in the changeover procedures and the like can be carried out in a greatly reduced time.
US10232360B1 Use of organic dopants to enhance acetylene hydrogenation catalysts
A composition comprising a supported hydrogenation catalyst comprising palladium and a support, wherein the supported hydrogenation catalyst is capable of selectively hydrogenating highly unsaturated hydrocarbons to unsaturated hydrocarbons; and a dopant comprising a fluorene structure. A method of making a selective hydrogenation catalyst including contacting a support with a palladium-containing compound to form a supported-palladium composition; contacting the supported-palladium composition with a dopant comprising a fluorene structure group to form a selective hydrogenation catalyst precursor; and reducing the selective hydrogenation catalyst precursor to form the selective hydrogenation catalyst. A method of selectively hydrogenating highly unsaturated hydrocarbons to an unsaturated hydrocarbon enriched composition by contacting a supported catalyst comprising palladium and a dopant comprising a fluorene structure with a feed comprising highly unsaturated hydrocarbon under conditions suitable for hydrogenating at least a portion of the highly unsaturated hydrocarbon feed to form the unsaturated hydrocarbon enriched composition.
US10232358B2 Pentasil-type zeolite, and method for manufacturing same
[Problem] The purpose of the present invention is to provide: a pentasil-type zeolite that combines a higher BET specific surface area and a higher acid amount than previously; and a method for manufacturing said pentasil-type zeolite.[Solution] A pentasil-type zeolite characterized in that the BET specific surface area thereof is 450 m2/g or more, and furthermore the acid amount thereof, measured by the ammonia-TPD method, is 0.38 mmol/g or more. This pentasil-type zeolite can be obtained by a manufacturing method which has a crystallization step for crystallizing a mixture containing tetrabutylphosphonium cations, a silica source, an alumina source, an alkali metal source, and water, and which is characterized in that the molar ratio of the alkali metal relative to the silica in the mixture is greater than 0.04 and less than 0.10.
US10232357B2 Crystalline ammonia transition metal molybdate
A hydroprocessing catalyst has been developed. The catalyst is a unique crystalline ammonia transition metal molybdate material. The hydroprocessing using the crystalline ammonia transition metal molybdate material may include hydrodenitrification, hydrodesulfurization, hydrodemetallation, hydrodesilication, hydrodearomatization, hydroisomerization, hydrotreating, hydrofining, and hydrocracking.
US10232355B2 Carbon nanotube-coated catalyst particle
The present invention applies carbon nanotubes to catalyst particles, thereby providing catalyst particles which are usable in fluidized bed reactions, have high catalytic activity, and are easy to handle. The catalyst particles are carbon nanotube-coated catalyst particles which each comprise a carrier particle and a coating layer disposed on the surface of the carrier particle, wherein the carrier particles are flowable in fluidized beds and the coating layer comprises carbon nanotubes which have metal nanoparticles supported thereon and/or which have been doped with nitrogen or boron. The carbon nanotube-coated catalyst particles are flowable in fluidized bed reactions.
US10232353B2 Gold-based catalyst for the oxidative esterification of aldehydes to obtain carboxylic esters
Catalysts for oxidative esterification can be used, for example, for converting (meth)acrolein to methyl (meth)acrylate. The catalysts are especially notable for high mechanical and chemical stability even over very long time periods, including activity and/or selectivity relatively in continuous operation in media having even a small water content.
US10232350B2 Photocatalyst functional film and method for producing the same
A photocatalytic functional film has a structure of a substrate, a barrier layer and a photocatalytic layer stacked one on another. The barrier layer is a SiO2 film, the photocatalyst layer comprises an amorphous TiO2 film, and particles of visible light responsive photocatalytic material formed on the surface of the amorphous TiO2 film. A method for producing a photocatalytic functional film includes: adding an alcohol solvent and an acid to a silicate precursor to obtain a SiO2 sol by dehydration and de-alcoholization reaction; applying and drying the SiO2 sol on a substrate to form a barrier layer; adding an alcohol solvent and an acid to a titanium precursor to obtain a TiO2 amorphous sol by dehydration and de-alcoholization reaction; and applying and drying a composition formed by mixing particles of visible light responsive photocatalyst material with the TiO2 amorphous sol on the barrier layer, to form a photocatalyst layer.
US10232349B2 Non-noble metal-supported zirconium phosphate catalyst for generating cyclic hydrocarbon, and method for preparing cyclic hydrocarbon by using same
This invention relates to a catalyst for preparing a cyclic hydrocarbon, which is a non-noble-metal supported on zirconium phosphate, and to a method of preparing a cyclic hydrocarbon, including preparing a cyclic hydrocarbon from a lignin derivative through hydrodeoxygenation and hydrogenation using the catalyst for preparing a cyclic hydrocarbon.
US10232346B2 Methods for the preparation of alumina beads formed by dewatering a highly dispersible gel
A process for the preparation of an alumina in the form of beads with a sulphur content in the range 0.001% to 1% by weight and a sodium content in the range 0.001% to 1% by weight with respect to the total mass of said beads is described, said beads being prepared by shaping an alumina gel having a high dispersibility by drop coagulation. The alumina gel is itself prepared using a specific precipitation preparation process in order to obtain at least 40% by weight of alumina with respect to the total quantity of alumina formed at the end of the gel preparation process right from the first precipitation step, the quantity of alumina formed at the end of the first precipitation step possibly even reaching 100%. The invention also concerns the use of alumina beads as a catalyst support in a catalytic reforming process.
US10232345B2 Aminoglycoside hydrogel microbeads and macroporous gels with chemical crosslink, method of preparation and use thereof
Methods and materials for the generation of amikacin antibiotic-derived microbeads, (FIG. 3). These beads may function as anion-exchange resins for use in pDNA purification as well as in situ capture of DNA from mammalian cells. New microresin and macroporous monolith based materials also are disclosed and may function for plasmid DNA binding and purification, mammalian whole cell genomic DNA extraction, and in-vitro cell culture.
US10232344B2 Solid sorbent materials for acid-gas separation
Solid sorbent materials have been prepared by combining polyethyleneimine (PEI) with silica precursors. The solid sorbent materials can be used, for example, for acid gas separation, gas purification, and water purification applications. Advantageously, such materials can be water stable and the capacity of such solid sorbent materials does not diminish substantially after repeated use and regeneration.
US10232342B2 Method, synthesis, activation procedure and characterization of an oxygen rich activated porous carbon sorbent for selective removal of carbon dioxide with ultra high capacity
The present disclosure pertains to materials for CO2 adsorption at pressures above 1 bar, where the materials include a porous material with a surface area of at least 2,800 m2/g, and a total pore volume of at least 1.35 cm3/g, where a majority of pores of the porous material have diameters of less than 2 nm as measured from N2 sorption isotherms using the BET (Brunauer-Emmett-Teller) method. The present disclosure also pertains to materials for separation of CO2 from natural gas at partial pressures of either component above 1 bar, where the materials include a porous material with a surface area of at least 2,200 m2/g, and a total pore volume of at least 1.00 cm3/g, where a majority of pores of the porous material have diameters of greater than 1 nm and less than 2 nm as measured from N2 sorption isotherms using the BET method.
US10232339B2 Fouling protection for an oligomerization reactor inlet
Disclosed herein are systems and processes which prevent fouling of a reactor inlet of an oligomerization reactor. The systems and processes involve placement of an inlet sleeve around at least a portion of a reactor inlet such that a curtain of inert material flows through an annular space coaxially with respect to an outer surface of the end of the reactor inlet and into the reactor.
US10232335B2 Method for producing β-eucryptite fine particles
The β-eucryptite fine particle production method of the invention includes spraying, into an atmosphere at 50° C. to a temperature lower than 300° C., a solution containing a water-soluble lithium salt, a water-soluble aluminum salt, and colloidal silica, in such amounts that the mole proportions among lithium atoms, aluminum atoms, and silicon atoms (Li:Al:Si) are adjusted to 1:1:1, to thereby dry the solution, and, subsequently, firing the dried product in air at 600 to 1,300° C.
US10232330B2 Dye dispensing system
An apparatus for dye dispensing is disclosed herein. The apparatus includes a controller and a tray. The tray communicates with the controller and is configured with at least one opening. At least one canister is configured with an identifier and a dye. The dye is associated with the identifier. A reader communicates with the controller. A dispenser comprises an actuator communicating with the controller and a lever arm. The lever arm is coupled to the actuator and configured with a projection. The reader, based on the identifier, identifies a selected dye in a selected canister associated with a dye formulation. When the selected canister is aligned with a dispensing area, the dispenser applies a downward force on the selected canister and dispenses the selected dye.
US10232324B2 Gas mixing apparatus
Embodiments of gas mixing apparatus are provided herein. In some embodiments, a gas mixing apparatus may include a container defining an interior volume, the container having a closed top and bottom and a sidewall having a circular cross section with respect to a central axis of the container passing through the top and bottom; a plurality of first inlets coupled to the container proximate the top of the container to provide a plurality of process gases to the interior volume of the container, the plurality of first inlets disposed such that a flow path of the plurality of process gases through the plurality of first inlets is substantially tangential to the sidewall of the container; and an outlet coupled to the container proximate the bottom of the container to allow the plurality of process gases to be removed from the interior volume of the container.
US10232323B2 Membranes for dewatering acid mixtures
The invention provides a membrane suitable for dewatering acidic mixtures, comprising a bridged organosilica directly applied on a macroporous support in the absence of an intermediate mesoporous or finer layer. The bridged organic silica comprises divalent C1-C9 organic groups A2 and/or trivalent C1-C9 organic groups A3 directly bound to the silicon atoms of the organosilica. In particular, the membrane comprises bis-silylmethane or bis-silylethane groups. The membranes effectively separate water from acidic mixtures at high temperatures and without decrease in performance for at least several months.
US10232313B2 Continuous diffusion denuding with moving denuding surface
A duct can be configured to receive a denuding gas flow. A solid denuding surface that is connected to a drive system can be configured to move the solid denuding surface within the duct while the solid denuding surface is continuously concentrating one or more gas-phase species from the denuding gas flow on the denuding surface. Also, a denuding gas flow can be passed along a denuding surface to concentrate one or more gas phase species from the denuding gas flow onto the denuding surface with a diffusion denuding action. The denuding surface can be moved while continuing to concentrate the one or more gas phase species from the denuding gas flow onto the denuding surface.
US10232309B2 Method and device for cool-drying a gas with circulating cooling liquid with bypass line
Method for cool drying gas, whereby the cool dryer is characterized by curves that show the setpoint for the evaporator temperature or evaporator pressure for a load as a function of the lowest gas temperature, whereby the method comprises the following steps:—the determination of a curve and Tset or pset as a function of the load that is required to cool the gas to LATset; the control of a supply of coolant from the compressor to an injection point (P) downstream from the expansion means and upstream from the compressor in order to make the evaporator temperature or evaporator pressure equal to Tset or pset.
US10232305B2 Direct air capture device
A vacuum chamber (2) for a direct air capture process and enclosing an interior space (13) for housing an adsorber structure (1) is given comprising a contiguous circumferential wall structure (115) along an axis (15), which circumferential wall structure (115) in an axial direction is closed by an inlet and an outlet axial wall (116), respectively. Both axial walls (116) comprise at least one closing stainless steel lid (6) allowing for, in an open position, gas to be circulated through the vacuum chamber (2) for passing an adsorber structure (1), and, in a closed position, to close the interior space (13) and to allow evacuation of the interior space (13) down to pressure of 500 mbarabs or less.
US10232304B2 Carbon dioxide concentration control system and carbon dioxide concentration control device
Consumed energy and cost relating to control of a carbon dioxide concentration is reduced. Each of CO2 concentration control systems (100 to 105) includes a measuring unit (20) that measures a CO2 concentration, a CO2 absorption unit (30) that has a CO2 absorption material (31) for absorbing CO2 at a rate depending on the temperature thereof, and a control unit (10) that controls the temperature of the CO2 absorption material (31) by using exhaust heat of a power system (40), so as to control a CO2 absorption rate of the CO2 absorption material (31).
US10232303B2 Sensor system and oxygen separator comprising a sensor system
The invention relates to an a sensor system (100) for quantitatively detecting at least one compound in a fluid mixture, said fluid mixture comprising the compound to be detected, wherein the sensor system (100) comprises a sorbent material (102) being capable of sorbing the at least one compound to be detected, wherein the sorbent material (102) undergoes a temperature change when sorbing the at least one compound; at least a first temperature sensor (104) for measuring the temperature of the sorbent material (102); and a control unit (110) being adapted for quantitatively determining the at least one compound to be detected based on the temperature change of the sorbent material (102). Such a sensor system (100) provides an improved measurement especially in the field of oxygen concentrators. The invention further relates to an oxygen concentrator (10) for generating oxygen enriched gas as well as to a method of quantitatively detecting at least one compound in a fluid mixture.
US10232302B2 Gas-adsorbing device and evacuated insulating material using same
A gas-adsorbing device (1) includes: a container (2); a gas adsorbent (3) configured to be disposed inside the container (2) so as to adsorb a gas; and an aeration member (4) having a predetermined aeration rate. The gas adsorbent (3) is disposed in a space formed by the container (2) and the aeration member (4). Further, the space is configured to be completely enclosed by the container (2) and the aeration member (4). In this configuration, it is possible to attain a gas-adsorbing device in which it is possible to reduce consumption of the gas adsorbent due to contact with air, even when the gas-adsorbing device is handled in air.
US10232301B2 Filter and filter media having reduced restriction
A pleated filter media comprises a plurality of pleats comprised of pleat segments extending in an axial direction between first and second axial ends and extending in a transverse direction that is perpendicular to the axial direction between first and second sets of pleat tips at least partially defined by first and second sets of bend lines. Axial flow channels are defined between the pleat segments in the lateral direction and the plurality of pleats has a width in the transverse direction that varies along the axial direction.
US10232298B2 Honeycomb structure
A honeycomb structure includes a pillar-shaped honeycomb structure body having a porous partition wall. The honeycomb structure body includes a plurality of cells defined by the partition wall so as to extend from a first end face to a second end face of the honeycomb structure body, the partition wall is formed by a porous body including a silicon phase as a main phase, and the silicon phase as the main phase has content of each of metals other than silicon and metals making up silicide that is 0.3 part by mass or less with respect to 100 parts by mass of silicon.
US10232294B2 Separation element and pressure accumulator system
A separation element for a pressure accumulator system for separating liquid from a media stream is provided with a hollow cylindrical filter body. The filter body has a support body and a coalescing stage filter medium radially outwardly of the support body. The filter body is flowed through radially by the media stream and separates a dirty side from a clean side of the separation element. First and second end disks are disposed on opposite sides of the filter body. A receiving recess is arranged centrally on the first end disk and is open toward the filter body interior. The receiving recess supports the separation element on a central tube of the pressure accumulator system. The second end disk has an outlet opening. Liquid that has been separated by the filter body from the media stream drains via the outlet opening of the second end disk from the separation element.
US10232290B2 Multistage complex water screen filter with automatic alarm in micro-irrigation and its composition method
The present invention relates to a self-alarm multi-stage complex screen filter for micro-irrigation and the assembly method thereof. The filter comprises a housing, an alarm, a multi-stage screen filtering element, and a segmented brush. The housing comprises a left housing, a middle housing, and a right housing. The multi-stage screen filtering element comprises a plurality of screen filter cylinders. The segmented brush comprises a plurality of bristle frames, a plurality of connecting rods, a connector and a power device. The middle housing is provided with a water inlet. The left housing is provided with a discharge pipe. The installation, disassembly, repair, maintenance of the filter of the present invention can be done more conveniently.
US10232275B2 Yo-yo having a magnetically supported bearing yoke integrated with the axle
A yo-yo having improved spin time is disclosed. The yo-yo has a body comprising two side members joined together at their centers by a fixed axle. A yoke for receiving a string in winding relation is magnetically supported for substantially frictionless rotation about the axle. A pair of radially-magnetized ring magnets disposed at opposite ends of the yoke are received within a corresponding pair of radially-magnetized ring magnets disposed within recesses in the side members. A pair of axially-magnetized ring magnets disposed at opposite ends of the yoke confront a corresponding pair of axially-disposed ring magnets set into the body side members. The magnets are magnetically polarized such that they mutually repel each other. As a result, the yo-yo is free to spin around the yoke for an extended period of time.
US10232274B2 System and method for multi-client control of an avatar using different, but related, views
A system for multi-client control of an avatar. In one embodiment, the system includes: (1) a game engine configured to execute game code configured to create a game in a game space and accept a response stream to allow said avatar to be controlled and (2) a cooperative play engine associated with said game engine for communication therewith and having a stereoscopic device driver configured to render left-eye and right-eye views of said game space, said cooperative play engine configured to: (2a) transmit said left-eye view toward a first client associated with a first player and (2b) transmit said right-eye view toward a second client associated with a second player.
US10232272B2 System and method for replaying video game streams
A system and method is provided that generates a game log that specifies game events during gameplay to enable efficient distribution of video game playback, facilitates the annotation of gameplay through content from users and others, and generates a video game stream that includes the game log and content. The system facilitates the efficient sharing of video game playback, as well as annotations from users and others. For example, e-sportscasters may use the system to broadcast video game playback with their commentary and/or graphical overlays. Video game players may use the system to share video game playback efficiently with other users. The system may also facilitate the sharing of loadout conditions and micro-transactions relevant to video game playback.
US10232269B1 Unlocking game content based on amounts of collaborative gameplay
This disclosure relates to unlocking game content for users of an online game based on amounts of collaborative gameplay. Groups of users interacting with the online game cooperatively are identified and amounts of cooperative gameplay engaged in by the individual groups are quantified. Content in the online game is made available to the groups of users based on the quantified amounts of cooperative gameplay. In implementations, the quantification of the amount of cooperative gameplay engaged in by the groups is made independent from achievement and/or successful accomplishment of any game objective in the online game by the groups.
US10232268B2 Promotion generation engine for a money transfer system
A money transfer system is promoted by providing a user access to a game or contest generated by a promotions engine computer. The user is directed to a customer relations portal accessible via an access device to participate in the game or contest. The customer relations portal comprising a server configured to manage the game or contest and associated with the promotions engine computer. A response is received from the user at the server related to the user's participation in the game or contest. The server determines whether the user is to receive a reward or prize based on the response from the user, and an output is provided to the user on the access device indicating whether the user is to receive the reward or prize.
US10232260B2 Information processing apparatus, information processing system, and program
Retrieval performance when selecting a game playing video can be improved. An information processing apparatus {12(n)} includes: a storage section (66) in which at least one tag and a tagging condition of the tag are stored in association with each other; and an attaching section (74) which, when playback data to be used to play back a game playing video of a game has been generated and an event during the play of the game satisfies the tagging condition, attaches the tag, which is associated with the tagging condition, to the playback data as an index of the game playing video.
US10232259B2 Apparatus, method and computer readable storage medium for collecting doobers in an electronic game
An apparatus, method and computer-readable storage medium for efficiently collecting doobers. A game area may be presented in a graphical user interface on a display device. The game area may include a game character associated with a first player, regions and objects within the regions. The character may move within the regions and interact with the objects. One or more doobers may be presented in the game area, and the doober(s) may be identified as collected by the first player in response to one or more inputs to the graphical user interface by the first player. The doober(s) may be marked as collected if an input is within a particular distance from the doober(s).
US10232258B2 Fusing game control inputs
A method for fusing game control inputs includes, on a computing device, receiving a first game control input from a first input device having a first housing and receiving a second game control input from a second input device having a second housing. The first game and second game control inputs are fused into a fused game control input mimicking a game control input from a single input device having a single housing. The fused game control input is provided to a video game application.
US10232254B2 Game controller with removable paddle accessory
A game controller includes a grip, one or more finger-actuatable controls on the grip, and a rim located on the grip. The rim defines an aperture. The game controller further includes a paddle-actuatable sensor accessible through the aperture and a pivot spaced apart from the aperture. The pivot is configured to removably affix a selected paddle accessory to the game controller and to translate a touch applied to the selected paddle accessory outside of the aperture to an actuation of the paddle-actuatable sensor inside the aperture.
US10232252B2 Information processing system, information processing method, program, and information storage medium
A front end server receives a request to start executing a game on at least one game server, the at least one game server being capable of executing at least one game, having an upper limit set to a total of amounts of resources that can be secured in executing at least one game, and executing a game as an object of execution when an amount of resources associated with the game as the object of execution can be secured. A management server starts a new game server when an amount of resources associated with the game according to the execution start request exceeds an amount of remaining resources that can be secured in each game server already started or being started at a time of receiving the execution start request. The management server makes one of the game servers execute the game according to the execution start request.
US10232249B2 Building brick game using magnetic levitation
Described herein are systems and methods for stacking block games, which may include a game board or base including magnetized portions and a hover platform having at least one magnet connected thereto and being suspended above the game board or base and in a floating or hovering arrangement that can be generated by magnetic repulsion between the magnet of the platform and the magnetized portions of the game board or base. Further, a plurality of game pieces may be arranged in a stacked orientation on the platform.
US10232248B2 Game machine operating device and game machine
A game machine operating device mounted on a game machine with a game board and provided on a front side of the game board includes: an operation unit which receives an operation; and a projection unit which radiates light in a direction toward the game board to project a first image on an area in a field of view of a player viewing the game board. The projection unit includes: a first light source; and a light guide into which light emitted from the first light source is guided. The light guide has a light diffusion pattern formed on one or both of a front surface and a rear surface, wherein light is emitted through the light diffusion pattern to form the first image. A part on which the light diffusion pattern is formed is disposed to be directed in the direction toward the game board.
US10232247B2 Instant ticket redundancy via multi-chromatic indicia
A redundantly printed security-enhanced document, printing method and system are provided for ensuring the meaning of the information imparted by variable indicia printed on documents with removable scratch-off coatings by the redundant printing. By printing the variable indicia with multiple colors, redundancy and integrity of the intended indicia is achieved. Additionally, inverted color indicia countermeasures to pinprick attacks are also disclosed. The redundantly printed document, methods and systems enhance the overall appearance of the redundantly printed document, and reduce the consequences possibly resulting from misprinted variable indicia.
US10232243B2 Rock climbing training apparatus
Disclosed herein is an exercise apparatus comprising a conveyor mechanism comprising a continuous track and a plurality of bars movable along the continuous track in a closed loop path. The plurality of bars extend lengthwise in a lateral direction across a width of the conveyor mechanism. The conveyor mechanism has a front side and a back side, opposite the front side. The plurality of bars move in a downward direction along the front side of the conveyor mechanism and in an upward direction along the back side of the conveyor mechanism. The upward direction and the downward direction are perpendicular to the lateral direction. The conveyor mechanism also comprises a plurality of carriage components movable along the plurality of bars in the lateral direction. The conveyor mechanism additionally comprises at least one hold coupled to each carriage component of the plurality of carriage components.
US10232242B2 Devices to improve swing technique, and methods of use thereof
Described herein are devices that can be used to improve swing technique and methods of using the same. The devices provide alerts indicating a trainee's use of proper and/or improper technique during a swing either in real-time or after a delay, thereby improving the trainee's swing technique, including body positioning. Exemplary uses include improving swing technique in baseball, golf, and similar sports or activities.
US10232236B2 Satellite golf club carrier
A satellite golf club carrier for porting a club subset from a golfing cart to the hole shot, easing the port through a balanced carrier grip and a place to place a subset of clubs without scattering clubs on the golfing ground near tee-off follow on stroke shots.
US10232234B2 Golf club heads and methods to manufacture golf club heads
Embodiments of golf club heads and methods to manufacture golf club heads are generally described herein. In one example, a golf club head may include a hollow body portion having a front portion, a rear portion, a toe portion, a heel portion, a bottom portion, a top portion, a plurality of ports on the bottom portion and a plurality of inner support portions in the hollow body portion. Other examples and embodiments may be described and claimed.
US10232233B2 Golf club head
A golf club head includes a metal body, a metal strike plate connected to the metal body, and a composite shell that is adhesively bonded to a crown portion of the body via corresponding abutment surfaces. A method for forming a golf club head comprises placing an uncured composite material between a core and a mold that comprises a first piece and a second piece. The second piece is moved towards the first piece such that the uncured composite material is compressed between the core and at least a portion of the mold. The uncured composite material is heated. A first portion of the golf club head is removed from the mold. A second portion of the golf club head is provided. The first portion is attached to the second portion. In certain arrangement, the second portion is formed from a metallic material.
US10232229B2 Ball collection device
A ball collection device, including a handle; a first tube segment and a second tube segment coupled substantially perpendicularly to the handle; a multi-directional roller ball coupled to the first and second tube segments; a crossbar coupled to the handle adjacent and substantially parallel to the first and second tube segments; a first arm coupled to and extending substantially perpendicular from the first tube segment; a first wing extending from the first arm that is configured to deflect objects downward; a second arm coupled to and extending substantially perpendicular from the second tube segment; a second wing extending from the second arm that is configured to deflect objects downward; and at least one roller rotatably mounted on each of the first and second tube segments and the crossbar.
US10232228B2 Sports ball funneling net with releasable restraining element
Described herein include various implementations of a ball funneling net that can capture sport balls, such as baseballs, directed into the ball funneling net. The ball funneling net can include a ball directing feature, such as a funnel, and a releasable restraining element that controls the sport balls from being released from the ball capturing net, such as from a distal dispensing end. In some implementations, a user can pick up a part of the ball directing feature and release the releasable restraining element thereby allowing any sport balls captured in the ball capturing net to exit the distal dispensing end. For example, the ball funneling net described herein can improve training efficiency in sports, such as baseball and softball, as well as reduce damage to equipment and improve user experience.
US10232227B2 Golf ball and method of manufacture
In a golf ball having a core and a cover of one or more layer encasing the core, an outermost layer of the cover is molded of a thermoplastic material selected from the group consisting of polyurethane, polyurea and mixtures thereof, and the surface of the cover is treated with a polyisocyanate compound that is free of organic solvent. A method of manufacturing the golf ball is also described. Such golf balls are endowed with an excellent spin performance and scuff resistance, in addition to which productivity of the golf balls is high.
US10232226B2 Golf ball
A golf ball 2 includes a core 4, a mid layer 6, and a cover 8. A difference DH in hardness between a surface and a central point of the core 4, a thickness Tm and a hardness Hm of the mid layer 6, a thickness Tc and a hardness Hc of the cover 8, and an amount of compressive deformation Sb of the golf ball 2 meet the following mathematical formulas (DH*Hm)/(Hc*Tc)>80 and ((Sb*Tc)/(Hc*Hm*Tm))*1000>0.75. A hardness Hc of the cover 8 is equal to or less than 40. A material of the cover 8 is a resin composition. The resin composition includes a polyurethane (A) and a polyrotaxane (B).
US10232221B1 Spring-loaded boot
Disclosed is a spring-loaded boot. The invention consists of a rigid boot bound to a set of plates, with shock absorbers situated on each end of, and sandwiched between, the plates. The top plate provides the platform for binding a ski boot, and the bottom plate provides ground contact and traction. The device allows the user to bounce with pogo-like motion. The rigid shell of the boot provides the ample ankle support and protection needed for rugged terrain.
US10232218B2 Multi-planar rotational platform and suspension device
The present invention relates to a device which enables a selective therapeutic exercise regimen by providing a tensioning mechanism attached to a rotatable platform along with the unique feature is where two trollies on curved rails operating on X-axis and Y-axis when pressure is applied, will work in unison to travel in any desired direction creating a unique spherically rotational reaction. The platform will react to changes in the operator's weight shifts and center of gravity placed upon it. When this novel multi-rotational aspect of the platform responds to subtle changes in the operator's center of gravity, movement of the platform will occur. These changes trigger muscular contractions around the joints of the operator responding to the rotation of the platform while the tensioning mechanism allows for selective resistance to the free movement of the platform enabling selective exercise and therapy routines for various muscle groups. Additionally, the present Multi-Planar Rotational Platform and Suspension Device offers easy scalability and uniform or non-uniform scaling in the X-axis, the Y-axis and/or the Z-axis.
US10232213B1 Multi-purpose exercise bench
An exercise bench comprises a pair of perforated side frames, each including a rear member projecting upward from a rear side of a base member, and an angled member fixed at an angle between the rear and base members. The pair of side frames are mutually aligned and fixed together at perforated forward and unperforated top cross members. A seat fixed between the pair of side frames at the angled members and attached thereto with pivot mechanisms is moveable along the side frames. The rear, base, and angled members are moveable relative to each other and fixable to at least one resistant band anchor.
US10232212B1 Exercise apparatus, studio, and methods
Provided is an exercise studio configuration including a floor, at least one overhead support, and at least one pair of resilient bands hanging from the at least one overhead support at a first end of each of the resilient bands. Each of the resilient bands has a free end distal to the first end and a connection member adapted for the connection of user accessories between the first end and the free end, the resilient bands being resilient between the first end and the free end with a consistent spring constant. A glove may be attached simultaneously at two locations thereof to the free end of at least one of the pair of resilient bands.
US10232208B2 Trampoline enclosure system
A trampoline comprising a trampoline frame having legs. The trampoline frame has a trampoline frame horizontal portion. A trampoline bed is suspended across the trampoline frame horizontal portion. Springs extend between the trampoline frame and trampoline bed. An enclosure is connected to the trampoline frame. The enclosure has an enclosure upper support. The enclosure supports an enclosure net. A pad system covers the springs. The pad system includes a wall pad extending upwardly from the springs and terminating at a pad system apex. The pad system further includes a buttress pad connected to the pad system apex at an apex angle from the wall pad, which is defined as an angle between a wall pad outside surface and the buttress pad. The buttress pad extends downwardly to cover at least partially the trampoline frame horizontal portion.
US10232202B1 Self contained stovetop fire suppressor with alert signal and method
An automatic stovetop fire suppressor with suppressor activation triggering an audible alert of a fire condition and method are provided herein. A plastic bottom lid is secured to a bottom of a can, forming a closed container. A fire suppressing agent and a sound board are housed within the closed container. As the fire suppressor actuator is triggered, the bottom lid lowers releasing the fire suppressing agent and tripping a sound board alert switch. A microcontroller generates a desired fire condition signal which is played across a low voltage magnetic transducer. The suppressor is user friendly, provides an automated release of fire suppressing agent in the presence of a stovetop fire, and emits a continuing audible alert signal until a user disables the same. The fire suppressing agent and battery powered sound board are stored in the closed from manufactured end to activation of the suppressor in a fire condition.
US10232200B2 Recessed concrete anchor
A fall protection permanently embedded safety anchor comprises a unitary housing having outwardly diverging side walls and an interior cavity. Opposed apertures in the side walls receive a uniformly curved retaining bar, the ends of which extend outside the cavity and are embedded in the concrete. The anchor may be easily installed stored and transported and installed in the field. The side walls terminate in an outwardly extending collar that receives a cover that is flush with the surrounding concrete surface.
US10232198B2 Method for detecting a fall of a worker and apparatus for detecting a fall of a worker
A method for detecting a fall of a worker attached to an anchor device includes steps for: a) measuring an orientation of a worker, using an orientation sensor with six axes on board a fall detection apparatus secured to the worker; b) calculating statistical properties representative of the measured orientation; and c) comparing statistical properties of reference values, a fall being considered to be detected only if the statistical properties correspond to the reference values according to predefined criteria, the comparison being done using an automatic classifier.
US10232197B2 Fermented cationic peptide-based antimicrobial extract compatible with anionic compounds
An antimicrobial composition compatible with anionic compounds is prepared by a process of contacting a cationic peptide-based antimicrobial extract with an ion exchange resin.
US10232193B2 Particle beam treatment system, particle beam treatment management system and method
According to an embodiment, a particle beam treatment system has: a CT device that is a three-dimensional image acquisition part installed in a treatment room for acquisition of a three-dimensional internal image on a day of treatment; a dose distribution display part that displays a dose distribution in the three-dimensional image acquired on the day of treatment and a dose distribution in treatment plan data designed in advance; a treatment management device that is a selection part to select whether or not to change the treatment plan data based on the dose distribution in the three-dimensional image acquired on the day of treatment and the dose distribution in treatment plan data designed in advance; and an irradiation part that irradiates an affected part with a particle beam according to the treatment plan data based on selection made by the treatment management device.
US10232192B2 Efficient treatment plan trade-off analysis
A planning image memory stores a volume diagnostic image. A user inputs data defining clinical objectives including organs-at-risk with a user interface device. An auto-planning module generates a candidate treatment plan. A trade-off module having a processor evaluates the treatment plan against the clinical objectives. When one or more objectives is not met, the trade-off module performs a trade-off analysis to determine an effect on other clinical objectives and generates at least one trade-off treatment plan which more closely meets the not met objectives. The candidate and at least one trade-off plan are displayed on a display device and/or analyzed by the processor and a final treatment plan is selected from the at least one trade-off or candidate treatment plan.
US10232191B2 Method of use of an embolic implant for radio-ablative treatment
A method of radio-ablation in conjunction with embolic implants used for pre-embolization of branch arteries in radio-ablation of the liver or other diseased tissue.
US10232188B2 Single cable apparatus and method for hyperthermic treatments
A medical apparatus operable to induce localized hyperthermia in a patient via an electromagnetic field emitted by an antenna of an applicator connected to an output of the medical apparatus includes a signal generator, a bidirectional coupler, and a controller. The signal generator generates a radio frequency signal as a function of an operating parameter to a single cable to an applicator. The bidirectional coupler provides the radio frequency signal generated by the signal generator to the output and receives a reflected signal from the output at the applicator. First and second low pass filters isolate the radio frequency signal and reflected signal from a temperature sensing signal transmitted via the single cable to at least one temperature sensor of the applicator.
US10232184B2 Extracorporeal unit for inspecting the insulation of an electrical wire of an implanted medical device
A system is provided for testing the electrical integrity of an implanted pacemaker or defibrillator lead. The system includes a container holding an electrically conductive solution, such as a saline solution. A voltage source and two electrodes are provided to pass an electrical current through the solution. To use the system, the proximal end of the electrical lead is disconnected from the implanted electronic device, passed through the saline solution and then electrically connected to a device/monitor. During testing, the device/monitor sends a test pulse through the lead and monitors electrical activity in the lead. To test sequential locations along the length of the proximal segment, the segment is drawn through the saline solution and between the electrodes while test pulses are sent and monitored. The monitor detects abnormal electrical activity in the lead indicative of a break in lead insulation.
US10232182B2 Detecting and responding to anti-tachyarrhythmia shocks
In some examples, an implantable medical device determines that another medical device delivered an anti-tachyarrhythmia shock, and delivers post-shock pacing in response to the determination. The implantable medical device may be configured to both detect the delivery of the shock in a sensed electrical signal and, if delivery of the shock is not detected, determine that the shock was delivered based on detection of asystole of the heart. The asystole may be detected based on the sensed electrical signal. In some examples, an implantable medical device is configured to revert from a post-shock pacing mode to a baseline pacing mode by iteratively testing a plurality of decreasing values of pacing pulse magnitude until loss of capture is detected. The implantable medical device may update a baseline value of the pacing pulse magnitude for the baseline mode based on the detection of loss of capture.
US10232181B2 Techniques for current steering directional programming in a neurostimulation system
A neurostimulation system comprises at least one neurostimulation lead configured for being implanted within tissue. The neurostimulation lead(s) carries a plurality of electrodes capable of being arranged in a two-dimensional pattern. The neurostimulation system further comprises a neurostimulator configured for delivering electrical stimulation energy to the electrodes to create a volume of activation, and an external control device including a current steering direction control element capable of being rotated about an axis. The external control device is configured for prompting the neurostimulator to deliver the electrical stimulation energy to the electrodes in a manner that gradually translates the volume of activation in a specific direction, and for defining the specific direction in which the volume of activation is translated in response to rotation of the direction control element about the axis.
US10232174B2 Non-invasive electrical and magnetic nerve stimulators used to treat overactive bladder and urinary incontinence
Transcutaneous electrical and magnetic nerve stimulation devices and methods of treating lower urinary tract disorders deliver energy noninvasively to nerves within a patient. The disorders comprise overactive bladder, urge incontinence, stress incontinence, urge frequency, non-obstructive urinary retention and interstitial cystitis/painful bladder syndrome. For example, a posterior tibial nerve of a patient is stimulated non-invasively. Protocol parameters are selected for a nerve stimulation session for treating each individual patient, where modules of the bladder of the patient are represented as coupled non-linear oscillators.
US10232173B2 Contactless electropermeabilization electrode and method
Devices and methods for delivering an electropermeabilizing pulse of electric energy to a tissue surface to enable delivery into cells in the tissue therapeutic substances. The device incorporates a source capable of generating a sufficient voltage potential to deliver a spark across a gap and delivers same to the tissue surface.
US10232171B2 Implant magnet system
A magnetic alignment system that can form part of a cochlear implant system. The magnetic alignment system prevents substantial movement of a magnet of an implanted component during an MRI procedure or allows for easy removal of the magnet to facilitate the MRI procedure.
US10232168B2 System for active skull replacement for brain interface and method of using the same
An active skull replacement system including an implant having an area A, an upper surface, and a bottom surface, adapted to be implanted at least in part into a skull of a subject so to substitute a portion of the skull, the bottom surface arranged to face at least in part a cranial cavity, and having a first wireless bidirectional data communication device, a device operably connected to the bottom surface of the implant, the device adapted to at least one of stimulate a physiological response and record a physiological parameter of the subject, and an external reader adapted to be placed on the scalp of the subject and including a second wireless bidirectional data communication device configured to communicate with the first wireless bidirectional data communication device of the implant to operate the device, wherein the external reader and the implant are fixed and aligned among each other through a magnetic device.
US10232161B2 Ultrasonic device for transversely manipulating drug delivery carriers and method using the same
An ultrasonic device for transversely manipulating drug delivery carriers includes a driving unit and a transducer. The transducer is electrically connected to the driving unit and has a piezoelectric sheet in a curved shape. The piezoelectric sheet includes a plurality of channels, and a phase difference is generated between every two of the channels by the driving unit for producing an acoustic vortex.
US10232160B2 Transdermal drug delivery apparatus and methods
A transdermal drug delivery apparatus includes a housing for being fastened to a user, a microneedle assembly for being engaged against the skin of the user, a first force provider for providing a first force for forcing the microneedle assembly outwardly from the housing and against the skin, a reservoir movably carried by the housing for containing the fluid and for being in fluid communication with the microneedle assembly, and a second force provider for providing a second force for causing at least some of the fluid to flow from the reservoir to the microneedle assembly after the reservoir has moved into fluid communication with the microneedle assembly.
US10232159B2 Microneedle based cell delivery
The invention relates to a device for use in skin improvement or repair, including promoting hair growth, comprising the use of microneedles for the transplantation of cells and a method employing the use of same.
US10232148B2 Balloon catheter system and method of using same
A system for dilating a stenosed vessel is provided. The system includes a balloon mounted on a catheter shaft, the balloon being composed of a first material and fibers forming a grid attached to a surface of the balloon or integrated within a wall thereof. The fibers are composed of a second material having less elasticity than the first material such that when the balloon is inflated beyond a predetermined pressure balloon regions protrude from the grid formed by the fibers.
US10232144B2 Electrically-responsive hydrogels
Implants comprising electrically-responsive hydrogel are described. Systems to provide electricity to induce response in hydrogel-containing implants are described. Methods for utilizing said system and methods for utilizing said hydrogel-containing implants are described.
US10232130B2 Anti-run dry membrane
An intravenous delivery system may have a liquid source containing a liquid, tubing, and an anti-run-dry membrane positioned such that the liquid, flowing form the liquid source to the tubing, passes through the anti-run-dry membrane. The anti-run-dry membrane may have a plurality of pores through which the liquid flows, and may be formed of a hydrophilic material that resists passage of air through the pores. The intravenous delivery system may further have a bubble point raising component that raises the bubble point of the anti-run-dry membrane. The bubble point raising component may, in some embodiments, be a high surface energy coating or additive.
US10232129B2 Injection device
An injection device includes a syringe having a body with a piston disposed therein with an open end along with a viscous fluid disposed in the body for injection by the piston. A needle assembly is provided which includes a cannula having a luer connection engageable with the syringe distal end with the luer connector including a hub. Mating engagement is provided by way of internal threads at the syringe distal end and external threads of a hub with a pitch sufficient to prevent detachment of the hub from the syringe distal end during ejection of the viscous fluid. In addition, a stepped cavity, disposed in the hub, further prevents detachment of the hub from the syringe distal end during ejection of the viscous fluid.
US10232128B2 Method for producing needle-equipped outer tube and needle-equipped outer tube
A method of manufacturing a needle-equipped outer tube includes a preheating step comprising heating a distal end connecting section to a temperature at or below a softening point of a material forming an outer tube member with a joint member inserted in a distal end connecting section of the outer tube member, and with a needle being inserted or inserted and fixed in the needle insertion hole; and a joint member welding step, performed after the preheating step, comprising thermally welding the joint member to the distal end connecting section of the outer tube member with a distal end portion of the joint member pressed toward the proximal end of the joint member by a pushing member with a pressing force in a range of 4 N to 30 N.
US10232126B2 Disposable pre-filled syringe
A disposable pre-filled syringe has a protecting tube, a medication filling tube, a separating plug, a pushing module, and a needle module. The medication filling tube is made of chemically inert material and is mounted in the protecting tube. The separating plug is mounted in an end of the medication filling tube. The pushing module is slidably inserted into the medication filling tube opposite to the separating plug. The needle module is mounted on an end of the protecting tube.
US10232123B1 Device and system for drug information detection
An injected dose detection device including a housing having a joint surface surrounding an injection device, a vibration sensor disposed in an internal part of the housing configured to detect at least one vibration signal of a dose-setting action based on a minimum vibration threshold, an acoustic sensor disposed in the internal part of the housing configured to detect at least one dosage click of the dose-setting action, a vibration transmitting element positioned directly between the vibration sensor and the injection device and configured to transmit the at least one vibration signal and a processing unit configured to process the at least one vibration signal from the dose-setting action and the at least one dosage click from the dose-setting action for generating set dose information corresponding to the injected dose wherein a bottom plate and a side wall of the vibration transmitting element form a shell structure to cover the vibration sensor.
US10232118B2 Drive assembly for a drug delivery device
A drive assembly for a drug delivery device includes a drive mechanism comprising a piston rod and a drive member to drive the piston rod to dispense a dose of drug and a dose member coupled to the drive member. The assembly further comprises a return mechanism comprising a spring member. The assembly further comprises a movable member which is coupled to the spring member. In a setting, the movable member is coupled to the dose member and, the movable member is movable from an initial position to a dose set position, thereby biasing the spring member. In the dispensing, the drive member and the movable member are decoupled such that the drive mechanism is operable by the user by application of a driving force to the drive mechanism, wherein the spring member of the return mechanism drives the movable member independently of the driving force towards its initial position.
US10232113B2 Infusion devices and related methods and systems for regulating insulin on board
Infusion systems, infusion devices, and related operating methods are provided. An exemplary method of operating an infusion device capable of delivering fluid to a user involves determining a current amount of active fluid in the body of the user, determining a threshold amount of active fluid in the body of the user, and automatically altering operation of the infusion device to modify delivery of the fluid to the user based on a relationship between the current amount and the threshold amount.
US10232112B2 Reservoir plunger position monitoring and medical device incorporating same
Apparatus are provided for infusion devices and related control systems and methods. In one embodiment, an infusion device includes a voided portion adapted to receive a shaft portion that includes a shaft coupled to a plunger of a reservoir. The shaft portion includes a detectable feature, and the infusion device includes a sensing arrangement proximate the voided portion to sense the detectable feature. In some embodiments, a control module is coupled to the sensing arrangement to determine a remaining amount of fluid in the reservoir based at least in part on the sensed position of the detectable feature. In other embodiments, the control module identifies an anomalous condition based at least in part on the sensed position of the detectable feature.
US10232109B2 Mini lead screw pump utilizing a magnetoresistive sensor and manufacturing method thereof
A mini lead screw pump monitors the rotation of a lead screw by using a magnetoresistive sensor and an MCU, and uses feedback to control the rotation direction and speed of the lead screw through a motor controller so as to control the speed of infusion to a patient. Furthermore, this mini lead screw pump can control the infusion speed of insulin according to the patient's blood sugar concentration monitored by CGM. This mini lead screw pump has several advantages, comprising high sensitivity, high reliability, low power consumption, low cost, and ease of use.
US10232107B2 Illuminated medical infusion
Disclosed are various embodiments for illuminated medical infusion including, for example, a medical infusion system which includes a source of illumination and an illuminating infusion line and wherein the illuminating infusion line includes an integrated fluid transmission channel and light transmission channel.
US10232105B2 Multi-chamber microfluidic device
A liquid handling device having an upstream liquid handling structure connected to a downstream liquid handling structure by a conduit. The upstream and downstream liquid handling structures are sealed or sealable such that the conduit provides the only fluidic communication paths between the upstream and downstream liquid handling structure. The device is arranged such that a driving force causes liquid in the upstream liquid handling structure to at least partially fill the conduit to separate gas in the upstream liquid handling structure from gas in the downstream liquid handling structure. With the device set up such that the two gas volumes are separated by a liquid volume, gas pressures and liquid flow in the device can be controlled by control of the driving force. The device may be arranged for rotation about an axis of rotation to provide the driving force.
US10232104B2 Cell filter separation system
Separation of a wash liquid from red blood cells is disclosed using a filter separation and pressure differential system. The filter may include a membrane filter.
US10232103B1 System, method, and composition for removing uremic toxins in dialysis processes
Methods and devices for providing dialysis treatment are provided. The device comprises a cartridge for providing regenerative dialysis, the cartridge comprising: a body having an inlet and an outlet and defining an interior, the interior including at least a layer comprising urease, a layer comprising zirconium oxide, a layer comprising zirconium phosphate, and a layer comprising carbon, wherein at least two of the layers are blended together to provide a gradient of the two materials.
US10232101B2 Gas exchange devices and related methods of use
A gas exchange system may include an elongate member including a liquid circuit and configured to be inserted into a body lumen, and a gas exchanger in fluid communication with the elongate member. A gas transfer fluid may be disposed within the liquid circuit of the elongate member. The gas transfer fluid may be configured to absorb carbon dioxide from a body fluid disposed in the body lumen, and subsequently release the carbon dioxide in the gas exchanger.
US10232100B2 Container for dialysis concentrate
A dialysis concentrate container for single-use, comprising a container portion (1, 2) which can be filled with dialysis concentrate and a connecting portion (13, 3) connected thereto for connecting the dialysis concentrate container to a dialysis machine, wherein the connecting portion (13, 3) has laterally spaced fluid connection elements (31) for connecting to a fluid outlet and a fluid inlet of the dialysis machine, wherein the container body (1, 2) is formed as a rigid box, wherein the connecting portion (13, 3) is further arranged at the lower end of the container body, wherein the connecting portion (13, 3) is formed by a plate body which can be clamped into a connecting block of the dialysis machine, and on the underside of which the fluid connecting elements (31) are formed, one of which being connected to a fluid inlet of the container body (1) and the other one being connected to a fluid outlet thereof.
US10232092B2 Stents and other devices having extracellular matrix coating
Provided herein are devices comprising a stent; and a coating on said stent comprising a polymer and an active agent, wherein the active agent comprises at least one of: extracellular matrix and an extracellular matrix component. Provided herein are methods of preparing a device comprising a stent and a coating on said stent; said method comprising: providing a stent; and forming a plurality of layers on said stent; wherein the coating comprises a polymer and at least one of said layers comprises one or more active agents; wherein at least a portion of the active agent comprises at least one of extracellular matrix and an extracellular matrix component.
US10232091B2 Stent for inhibiting restenosis and stimulating reendothelialization prepared by femtosecond laser processing and method of preparing the same
Provided are a stent in which a surface of a stent strut is treated by femtosecond laser radiation and is modified by a natural polymer and a method of preparing the stent. The stent and the preparing method may inhibit restenosis and stimulate reendothelialization.
US10232086B2 Three-dimensional porous biodegradable cell scaffold
Disclosed are composites comprising water-soluble polymeric fibers dispersed in a biodegradable polymer matrix, as well as methods of making and using such composites.
US10232079B2 Gel-forming system for removing urinary calculi and fragments thereof
Primarily described are gel-forming systems, consisting of or comprising a composition (A), comprising one or several cationically crosslinkable polymer(s), and a composition (B), comprising one or several crosslinking agent(s) for crosslinking the cationically crosslinkable polymer(s) for use in a method for removing urinary calculi and/or fragments thereof, more particularly kidney stones and/or fragments thereof, from a region of the urinary tract, more particularly a kidney, that contains urinary calculi and/or fragments thereof, more particularly kidney stones and/or fragments thereof, that are to be removed, with the following steps: (i) providing the compositions (A) and (B), (ii) introducing the compositions (A) and (B) into a region of the urinary tract, more particularly the kidney, that contains urinary calculi and/or fragments thereof, more particularly kidney stones and/or fragments thereof, that are to be removed, under conditions enabling crosslinking of the cationically crosslinkable polymer(s) upon contact of composition (A) with composition (B) so that a crosslinked gel is formed that partly or fully surrounds the urinary calculi and/or fragments thereof, more particularly kidney stones and/or fragments thereof, that are to be removed, (iii) removing the crosslinked gel together with the urinary calculi and/or fragments thereof, more particularly kidney stones and/or fragments thereof, that are surrounded by it from the urinary tract, more particularly the kidney.
US10232076B2 Purified hydrogen peroxide gas generation methods and devices
The present disclosure provides for and includes improved devices and methods for the production of Purified Hydrogen Peroxide Gas (PHPG) that is substantially non-hydrated and substantially free of ozone.
US10232074B2 Scented electronic candle device
Scented electronic candle devices are described that facilitate operation and usage of a variety of features such as light or scent or movement of the flame, or a combination thereof. The disclosed features also include multiple settings for the variety of features. For instance, the scent feature can be activated or deactivated by multiple switches, remote, sensors, timers, or similar devices. In addition, the intensity of the scent features can be increased or decreased by increasing or decreasing the amount of heat or air. Similarly the light feature can be activated, deactivated, or set on a timer. Additionally, the scented electronic candle devices can be equipped with rechargeable batteries that can be charged using a wireless charging station or by connecting the scented electronic candle device to an electrical wall outlet.
US10232072B2 Devices, systems and methods for treating medical devices having passageways with ozone gas
The present disclosure is generally related to devices, methods and systems for cleaning, disinfecting and/or sterilizing a medical device, medical hoses and tubes and accessories thereof with ozone gas, in particular the disclosure relates to devices, methods and systems with multiple receptacles for providing closed-loop fluid pathways to distribute ozone gas to inner passageways and the outer compartments of medical devices. The devices in accordance with an embodiment of the disclosure have two or more receptacles for distributing ozone gas, a gas-tight compartment, an ozone operating system, and one or more connector units configured to fluidly migrate ozone in closed-loop treatment systems.
US10232067B2 Mobile disinfector using UV LED
A mobile disinfector using UV LEDs can include: a case forming an exterior structure of the disinfector; a cover including two parts coupled to respective sides of the case and including openings formed on the cover; and LED units exposed to outside through the openings formed on the cover. Since the cover is coupled to the case such that an angle between the cover and the case is adjusted, an irradiation angle of light emitted to the outside from the LED units is controlled.
US10232066B2 High intensity narrow spectrum light indicator systems
Indicator systems and methods associated with high intensity narrow spectrum light are provided. In one example embodiment, a lighting system can include one or more high intensity narrow spectrum (HINS) light sources configured to emit HINS light. The system can further include an indicator circuit configured to provide at least one indicator associated with one or more parameters of the HINS light and/or operational performance of the HINS light sources.
US10232061B1 Freeze-dried formulation for gas-filled microvesicles
A freeze-dried powder composition comprising a phospholipid and a polyethylene glycol, said polyethylene glycol having a percentage of folded polymeric chains of 40% or higher. The composition is suitable for preparing gas-filled microvesicles.
US10232060B2 CEST systems exhibiting a concentration independent responsiveness
The present invention relates to the use of non-equivalent mobile protons belonging to NMR distinguishable stereoisomers of a CEST agent in a ratiometric based CEST imaging procedure and to Lanthanide (III) complex compounds displaying at least two NMR-distinguishable stereoisomers in solution useful as concentration independent CEST responsive agents.
US10232059B2 Functionalized magnetic nanoparticles and use in imaging amyloid deposits and neurofibrillary tangles
The present disclosure provides functionalized magnetic nanoparticles (MNPs) comprising a functional group that binds to β-amyloid deposits and/or neurofibrillary tangles. The present disclosure provides compositions comprising the functionalized MNPs, and methods of using the functionalized MNPs in imaging β-amyloid deposits and neurofibrillary tangles.
US10232055B2 RNA containing modified nucleosides and methods of use thereof
This invention provides RNA, oligoribonucleotide, and polyribonucleotide molecules comprising pseudouridine or a modified nucleoside, gene therapy vectors comprising same, methods of synthesizing same, and methods for gene replacement, gene therapy, gene transcription silencing, and the delivery of therapeutic proteins to tissue in vivo, comprising the molecules. The present invention also provides methods of reducing the immunogenicity of RNA, oligoribonucleotide, and polyribonucleotide molecules.
US10232053B2 Immunomodulatory oncolytic adenoviral vectors, and methods of production and use thereof for treatment of cancer
Disclosed herein are compositions and methods for treating cancer in a subject. This involves administering an oncolytic virus containing a heterologous DNA sequence encoding one or more immunomodulatory and/or immunostimulatory polypeptide(s) of interest to the subject under conditions effective to enhance an anti-tumor immune response in the subject, and to treat cancer. It also relates to a method of enhancing the delivery to and distribution within a tumor mass of therapeutic viruses.
US10232050B1 Multi-functional particles and methods of using the same
Provided herein are multi-functional particles. The particles may include poly(lactide-co-glycolide)-g-polyethylenimine (PLGA-g-PEI (PgP)), at least one targeting moiety, at least one therapeutic agent, and/or at least one nucleic acid. Also provided herein are methods of using the multi-functional particles.
US10232049B2 Targeted therapeutics
The present invention provides pharmacological compounds including an effector moiety conjugated to a binding moiety that directs the effector moiety to a biological target of interest. Likewise, the present invention provides compositions, kits, and methods (e.g., therapeutic, diagnostic, and imaging) including the compounds. The compounds can be described as a protein interacting binding moiety-drug conjugate (SDC-TRAP) compounds, which include a protein interacting binding moiety and an effector moiety. For example, in certain embodiments directed to treating cancer, the SDC-TRAP can include an Hsp90 inhibitor conjugated to a cytotoxic agent as the effector moiety.
US10232048B1 Apitherapy method and composition
A bee venom composition and method for preparing such a composition. The bee venom can be placed in a base that allows it to be applied directly to the skin. Skin penetration enhancers promote percutaneous absorption to increase the speed at which the effects of the bee venom are experienced. A skin penetration enhancer is also disclosed.
US10232041B2 Combination of lenalidomide and polypeptide construct, and uses thereof
Methods for cancer treatment include administering to a cancer patient an anti-CD38 antibody-attenuated human IFN alpha-2b construct and lenalidomide or pomalidomide. Tumors that may be treated according to these methods include tumors which comprise CD-38 expressing tumor cells, including B-cell lymphoma, multiple myeloma, non-Hodgkin's lymphoma, chronic myelogenous leukemia, chronic lymphocytic leukemia, and acute lymphocytic leukemia.
US10232039B2 Compositions and methods for the treatment of tissue fibrosis
Provided are methods of treating tissue fibrosis comprising administering to a subject in need of treatment an effective amount of an agent that inhibits a hyaluron synthase (HAS) or CD44. Further provided are methods of inhibiting myofibroblast invasion, or of reducing matrix deposition in the lung, the methods comprising administering to a subject in need of treatment an effective amount of an agent that inhibits a HAS or CD44. Further provided are methods of determining the progression of pulmonary fibrosis, the methods comprising determining the level of matrix metalloproteinase expression in a cell, and comparing the level of expression to that of a control cell, wherein an increased level of expression relative to the control cell indicates progression of the disease.
US10232036B2 Vaccine formulation, preparation method therefor and use thereof
The present invention provides a vaccine formulation, a preparation method therefor and a use thereof. The vaccine formulation comprises a vaccine carrier and an antigen component, wherein the vaccine carrier is obtained by hydrothermal transformation of microorganisms. The vaccine formulation of the present invention is obtained by compounding the vaccine carrier obtained by hydrothermal transformation of microorganisms with the antigen component.
US10232034B2 Compositions comprising CH505 envelopes, and trimers
In certain aspects the invention provides a selection of HIV-1 envelopes suitable for use as immunogens, and methods of using these immunogens to induce neutralizing antibodies. In certain embodiments, the immunogens are designed to trimerize. In other embodiments, the immunogens comprise an immune modulating component.
US10232033B2 Respiratory syncytial virus vaccine
A respiratory syncytial virus (RSV) vaccine comprising a recombinant fusion protein antigen. In one embodiment, the recombinant fusion protein antigen comprises a phosphoprotein (P) moiety, wherein the P moiety is a polypeptide that shares at least 90% identity to the polypeptide represented by SEQ ID NO 2 or SEQ ID NO 4; and a flagellin moiety, wherein the flagellin moiety is a polypeptide that shares at least 90% identity to the polypeptide represented by SEQ ID NO 8; whereby the P moiety and flagellin moiety are covalently coupled so as to form a linear polypeptide.
US10232031B2 Influenza virus reassortment
New influenza donor strains for the production of reassortant influenza B viruses are provided.
US10232028B2 Compounds and methods for affecting cytokines
The present invention discloses isolates and fractions from a phyto-percolate and methods for affecting various cytokines by administering an effective amount of one or more of said isolates or fractions to an animal. In various exemplary embodiments, the isolates are useful for the treatment of bovine, canine and swine infection or inflammation, including bovine mastitis, by regulation of TNF-a, lactoferrin, IFN-γ, IL-I β, serum amyloid-A (SAA), IL-6 and/or β-defensin associated with infection or an immune response generally.
US10232026B2 Vaccine for mycoplasma infection
Disclosed is a vaccine which has a high therapeutic effect on mycoplasma infection and is highly safe. For the purpose of developing effective therapeutic methods for mycoplasma infection, mycoplasma-mimic particles which are effective as a vaccine for mycoplasma infection are provided, and also provided are bacterium-mimic particles including common bacteria. Bacterium-mimic particles such as mycoplasma-mimic particles can be provided by producing liposome particles in which a lipid antigen specific to a pathogenic bacterium such as mycoplasma is contained as a liposome-constituting lipid component. The administration of the mycoplasma-mimic particles enables the induction of a potent immunological activity in living bodies. The mycoplasma-mimic particles can be used as an excellent vaccine for the prevention or treatment of mycoplasma infection.
US10232018B2 ACTH for treatment of acute respiratory distress syndrome
Provided herein are methods of treatment of acute respiratory distress syndrome comprising administration of adrenocorticotropic hormone (ACTH). or fragment, analog, complex or aggregate thereof, or any combination thereof, to an individual in need thereof.
US10232017B2 Method of treating cancer by administering tumor necrosis factor receptor ligand superfamily (TNFRSF) single-chain polypeptides
Polypeptides and agents that bind a TNF receptor superfamily protein are disclosed, particularly agents that specifically bind GITR, OX40, or CD40. The polypeptides or agents may include fusion polypeptides, particularly polypeptides comprising GITRL, OX40L, or CD40L and/or bispecific agents. Also disclosed are methods of using the polypeptides or agents for inducing and/or enhancing the immune response, as well as methods for the treatment of diseases such as cancer.
US10232014B2 Tear lipocalin muteins binding IL-4 R alpha
The present invention relates to novel muteins derived from human tear lipocalin, which bind to IL 4 receptor alpha. The sequences of the muteins comprise particular combinations of amino acids. In particular a mutated amino acid residue is present at any one or more of the sequence positions 27, 28 30, 31, 33, 53, 57, 61, 64, 66, 80, 83, 104-106 and 108 of the linear polypeptide sequence of the mature human tear lipocalin. A mutated amino acid residue is also present at any 2 or more of the sequence positions 26, 32, 34, 55, 56, 58 and 63 of the linear polypeptide sequence of the mature human tear lipocalin. The invention also provides a corresponding nucleic acid molecule encoding such a mutein and a method for producing such a mutein and its encoding nucleic acid molecule.
US10232002B1 Oncolytic HSV1 vectors and methods of using the same
Malignant tumors that are resistant to conventional therapies represent significant therapeutic challenges. An embodiment of the present invention provides an oncolytic virus capable of killing target cells, such as tumor cells. In various embodiments presented herein, the oncolytic viruses described herein are suitable for treatment of several types of cancer, including glioblastoma.
US10232001B2 Selection and use of lactic acid bacteria preventing bone loss in mammals
The present invention comprises a method for selecting lactic acid bacterial strains effective for preventing bone loss in humans and strains that have been selected according to the presented method. The selection method is based on the strain's capability of reestablishing an altered microbial community to normal and/or harboring at least one of four specific SNPs.
US10232000B2 Stem cells derived from basal portion of chorionic trophoblast layer and cell therapy comprising same
The present disclosure relates to stem cells derived from the basal portion of the chorionic trophoblast layer (bCT), which is a part of the issues of the placenta, and cell therapy comprising same. Stem cells derived from the basal portion of the chorionic trophoblast layer according to the present invention exhibit uniform growth characteristic, and superb proliferation and differentiation characteristic as compared with the conventional stem cells derived from the full placenta or other tissues, and exhibit excellent tissue regeneration effect in an animal model, thus can be effectively used in cell therapy.
US10231996B2 Biocampatible polymer coated silver Prussian blue nanoparticles (SPB-NPs: Ag3[Fe(CN) 6])
The present invention relates to highly biocompatible or nontoxic PVP (poly(n-vinyl-2-pyrrolidone) coated silver prussian blue nanoparticles (SPB-NPS: Ag3[Fe(CN)6] where PVP acts as stabilizing or capping agent. The as-synthesized nanoparticles (SPB-NPs) have been thoroughly characterized by several analytical tools. The SPB-NPs are highly stable for more than two weeks towards different physiological buffers or solutions with different pH (pH=6, −7.4 & −8). These nanoparticles (SPB-NPs) exhibit biocompatibility towards various normal cells (HUVEC, CHO, & ECV304) but show significant inhibition of proliferation of different cancer cells in vitro and tumor growth in C57/BL6/J mice model (aggressive murine melanoma cancer model: B16F10). Additionally, the SPB-NPs show excellent antibacterial activity towards gram-negative (E. coli) and gram-positive (B. subtilis) bacteria. Consider all results together; these biocompatible SPB-NPs would be potentially useful for the development towards alternative anti-cancer agent as well as anti-bacterial agent in near future.
US10231994B2 Selenium-containing compositions and uses thereof
The use of selenite- or selenate-containing preparations supplemented with pharmaceutically acceptable or food-compatible acids for the preparation of an agent intended for topical or buccal application or mucosal administration is described.
US10231988B2 Patatin-like phospholipase domain containing 3 (PNPLA3) iRNA compositions and methods of use thereof
The present invention relates to RNAi agents, e.g., double stranded RNAi agents, targeting the Patatin-Like Phospholipase Domain Containing 3 (PNPLA3) gene, and methods of using such RNAi agents to inhibit expression of a PNPLA3 gene and methods of treating subjects having Nonalcoholic Fatty Liver Disease (NAFLD) and/or a PNPLA3-associated disorder.
US10231987B2 Maintenance of platelet inhibition during antiplatelet therapy
A method for reducing or maintaining platelet inhibition in a patient by administering cangrelor prior to an invasive procedure is described. The method of this invention can be used for patients in need of antiplatelet therapy or at risk of thrombosis. The method can further be used in patients who were previously treated with long-acting platelet inhibitors without increasing the risk of excessive bleeding.
US10231983B1 Use of ACTH in assessment and prophylactic treatment of hypokalemia associated with glucocorticoid receptor modulator treatment of Cushing's syndrome patients
This invention provides new methods for a) identifying Cushing's Syndrome patients at high risk of developing hypokalemia during glucocorticoid receptor modulator (GRM) treatment, and b) for prophylactically treating such patients to prevent, or reduce the severity of, hypokalemia. Patients at such high risk may be identified prior to their developing hypokalemia. Such a patient may be an adult patient with endogenous Cushing's Syndrome having type 2 diabetes mellitus or glucose intolerance to control hyperglycemia secondary to hypercortisolism. Patients may be identified by an above-threshold level of ACTH or cortisol in a patient sample taken post-GRM administration or pre-GRM administration, respectively. Upon identifying such a patient prior to the development of low potassium, the present methods provide for prophylactically treating the patient by administration of one or more hypokalemia treatments concurrently with an increased dose of GRM or with an initial dose of GRM to prevent hypokalemia.
US10231980B2 Cortexolone 17alpha-benzoate for use in the treatment of tumours
The present invention provides certain cortexolone derivatives of formula (I), and the same for use as antitumor active ingredients for the curative or adjuvant, or neoadjuvant or palliative treatment of precancerous lesions, dysplasias, metaplasias and tumor diseases, including malignant neoplasias and metastasis. Another aspect of the invention relates to pharmaceutical compositions comprising cortexolone derivatives of formula (I) as active ingredients and at least one physiologically acceptable excipient, and to the use of said pharmaceutical compositions as antitumor medicinal products.
US10231976B2 Methods for the use of progestogen as a glucocorticoid sensitizer
Provided are methods and kits for administering progestogen as a glucocorticoid sensitizer to restore corticosteroid sensitivity or reverse the glucocorticoid insensitivity or enhance glucocorticoid sensitivity, in order to treat one or more glucocorticoid insensitivity related diseases or conditions. For example, these include methods for reversing the glucocorticoid insensitivity in a subject having no history of menstrual cycle-related exacerbation or allergy to self-hormones, particularly progesterone, such as premenstrual or perimenstrual deterioration in the symptoms, e.g., premenstrual worsening of atopic dermatitis or premenstrual exacerbations of asthma, and exhibiting relatively or totally refractory responses to glucocorticoid therapy, e.g., glucocorticoid resistance. The methods and kits provide for the administration of a sex hormone to the subject who is corticosteroid dependent or corticoid resistant or unresponsive or intolerant to corticosteroids.
US10231975B2 Use of aerosolized levofloxacin for treating cystic fibrosis
Methods for treating cystic fibrosis. The method includes administering to a human in need thereof an aerosol solution comprising levofloxacin or ofloxacin and a divalent or trivalent cation. More particularly, the method includes administering the aerosol solution to a human having a pulmonary infection comprising P. aeruginosa.
US10231967B2 Compounds and their use as BACE inhibitors
The present invention relates to compounds of formula (I) and their pharmaceutical compositions. In addition, the present invention relates to therapeutic methods for the treatment and/or prevention of Aβ-related pathologies such as Down's syndrome, β-amyloid angiopathy such as but not limited to cerebral amyloid angiopathy or hereditary cerebral hemorrhage, disorders associated with cognitive impairment such as but not limited to MCI (“mild cognitive impairment”), Alzheimer's disease, memory loss, attention deficit symptoms associated with Alzheimer's disease, neurodegeneration associated with diseases such as Alzheimer's disease or dementia including dementia of mixed vascular and degenerative origin, pre-senile dementia, senile dementia and dementia associated with Parkinson's disease, progressive supranuclear palsy or cortical basal degeneration.