Document Document Title
US10214855B2 Method for making modified cellulose products
Method for making modified cellulose products comprises —processing cellulose pulp to modified cellulose pulp at a manufacturing location to increase the susceptibility of fibers to disintegration, —setting the modified cellulose pulp to a suitable dry matter content, and —transporting the modified cellulose pulp at set dry matter content to a location of use, where the modified cellulose pulp is disintegrated to nanofibrillar cellulose.
US10214854B2 Method of dyeing knitted fabrics, and fabric and vamp fabric with predetermined color using the same
A method of dyeing knitted fabrics and fabric and vamp fabric with predetermined color using the same are provided. The method includes steps of: providing a plain knitted fabric; entirely spray dyeing the fabric by dye liquor containing nano-particles through the printing and spraying process; executing a high temperature process or a steam process of a thermally drying process to the dyed knitted fabric so that the nano-particles can attach into the fabric of the knitted fabric, and forming the knitted fabric with the predetermined color after the knitted fabric is dyed. The fabric and the dyeing method provided can therefore reduce the production of sewage effectively.
US10214852B2 Portable garment steamer
A steamer includes a housing, a power cord configured to be selectively coupled to an external power source, a battery, a fluid reservoir positioned in the housing, a reservoir heating element configured to preheat fluid in the fluid reservoir, a steam generating device operable to receive preheated fluid from the fluid reservoir and generate steam, and a nozzle in fluid communication with the steam generating device. The reservoir heating element receives power from the external power source when the power cord is in communication with the external power source. The steam generating device receives power from the battery when the power cord is unplugged from the external power source. The nozzle is configured to receive the steam from the steam generating device and discharge the steam through the nozzle.
US10214850B2 Intelligent electronic system for removing wrinkles on textile clothes and method for carrying out said wrinkle removal
An intelligent electronic system for removing wrinkles from a textile clothes load, including an electronic integrated circuit of the microcontroller type placed preferably integrally on the mainboard of the dryer machine located on the control panel, an user interface located preferably on the control panel allowing communications between the user and the dryer machine, and a water-injection means located at the drum's air inlet. A process for removing wrinkles on textile clothes is also disclosed.
US10214844B2 Washing machine appliance out-of-balance detection
A method for operating a washing machine appliance includes flowing a volume of liquid into a tub, agitating articles within the tub for a first period, the tub containing the volume of liquid, and measuring movement of the tub during agitation of the articles within the tub, the tub containing the volume of liquid. The movement is measured as one or more displacement amplitudes using an accelerometer and a gyroscope. The method further includes agitating articles within the tub for a second period when the final measured movement is greater than an out-of-balance movement threshold, the tub containing the volume of liquid. The method further includes draining liquid from the tub when the final measured movement is less than the out-of-balance movement threshold, and spinning a basket after draining liquid from the tub.
US10214839B2 System and method for manufacturing net shape preform from textile strips
A preform manufacturing apparatus comprising a supply of fiber strip, a moveable positive fiber strip delivery mechanism coupled between a desired lay down location and the supply of fiber strip to positively deliver and orient the supply of fiber strip to the desired lay down location, and an electronic unwinder coupled to the supply of fiber strip is described herein. The electronic unwinder is configured to interact with the moveable positive fiber strip delivery mechanism.
US10214833B1 Additive manufacturing of crystalline materials
The present invention relates to additive manufacturing methods, in which crystalline materials can be formed by using a liquid precursor. In particular embodiments, the crystalline material is a perovskite. The methods include the use of a thermal voxel, which can be translated to form any arbitrary pattern of initial crystalline seed structure(s). Then, the seed structure can be incubated to promote crystal growth and/or crystal dissolution, thereby providing a patterned crystalline material.
US10214832B2 Apparatus for recovery of material generated during electrochemical material removal in acidic electrolytes
A system for recycling machined metal produced by an electrochemical material removal process. The system includes a machining unit and an electrowinning unit. The machining unit includes an anode to receive a workpiece, a cathode tool, and a first pulse generator to provide a voltage or current waveform between the anode and the cathode tool. The electrowinning unit includes an electrowinning cathode, an electrowinning anode, and a second pulse generator to provide a voltage or current waveform between the electrowinning anode and the electrowinning cathode. The machining unit is in fluid communication with the electrowinning unit.
US10214831B2 One-piece electroformed metal component
The invention relates to a one-piece metal component including an electroformed metal body, the external surface of the body including, only over or to a predetermined depth, less trapped hydrogen than the rest of the electroformed metal body causing a hardening relative to the rest of the body in order to improve the wear resistance of the one-piece component while preserving a relative magnetic permeability of less than 10 and the ability to be driven or pressed fit.
US10214830B2 Substrate holder and plating apparatus
A substrate holder for holding a substrate, such as a wafer, is disclosed. The substrate holder includes a seal ring which can be brought into contact with a peripheral portion of the substrate, a support ring supporting the seal ring, and a fixing ring pressing the seal ring against the support ring. The fixing ring includes an annular portion having an inner circumferential surface and an outer circumferential surface, each of which is constituted by a tapered surface. The fixing ring further includes a seal-ring pressing portion connected to the annular portion, and a regulation ring projecting radially inwardly from the seal-ring pressing portion. The regulation ring has an inside diameter which is smaller than an inside diameter of the seal ring.
US10214825B2 Method of depositing one or more layers of microspheres to form a thermal barrier coating
A method of forming a thermal barrier coating onto a surface of a ferrous alloy or nickel alloy component part involves depositing a layer of hollow microspheres to a surface of the component part or to a previously deposited layer of hollow microspheres through heating and cooling of a metallic precursor setting layer composed of copper, a copper alloy, or a nickel alloy. Once deposited in place, the layer(s) of hollow microspheres are heated to sinter the hollow microspheres to each other and to the surface of the ferrous alloy or nickel alloy component part to form an insulating layer.
US10214824B2 Erosion and wear protection for composites and plated polymers
A composite component and a plated polymer component are disclosed. The composite component may comprise a body portion formed from an organic matrix composite, a first metal coating applied to a surface of the body portion, and an outer metal layer on the first metal coating that is erosion-resistant. The plated polymer component may comprise a polymer substrate, a metal plating layer applied to a surface of the polymer substrate, and at least one selectively thickened region in the metal plating layer. The at least one selectively thickened region may assist in protecting the plated polymer component against wear and/or erosion.
US10214818B2 Anti-corrosive zinc primer coating compositions comprising hollow glass spheres and a conductive pigment
The present invention concerns anti-corrosive coating compositions, in particular coating compositions for protecting iron and steel structures. In particular, the present invention relates to silicate-based coating compositions comprising particulate zinc, conductive pigments, and glass hollow microspheres. The invention furthermore concerns a kit of parts containing the composition, a method for its application, as well as metal structures coated with the composition.
US10214815B2 Surface treated aluminum nitride baffle
Methods and apparatus relating to aluminum nitride baffles are provided herein. In some embodiments, a baffle for use in semiconductor process chambers may include a body comprising aluminum nitride and a metal oxide binding agent, wherein a ratio of aluminum nitride to metal oxide on a surface of the body is greater than or equal to the ratio within the body. In some embodiments, the body may have a center stem and an outer annulus coupled to and extending radially outwards from a lower portion of the center stem. In some embodiments, a method of fabricating a baffle may include sintering aluminum, nitrogen, and a metal oxide binding agent to form a body of the baffle, the body having excess metal oxide binding agent disposed on a surface thereof; and removing a bulk of the excess metal oxide binding agent from a surface of the body.
US10214803B2 Method for machining a cylinder wall of an internal combustion engine
A method for machining a wall of a cylinder of an internal combustion engine, in which recesses in the wall are introduced by mechanical machining. The invention is characterized in that the wall is radiated with a medium under high pressure after the mechanical machining in order to introduce micro-recesses.
US10214801B2 Nanoparticle-reinforced composites and methods of manufacture and use
Composite structures and methods of their manufacture are provided. In one embodiment, the composite structure includes a substrate which includes a relatively soft material, and nanoparticles which include a relatively hard material and which are embedded (i) within at least a surface region of the substrate, or (ii) uniformly within and throughout the substrate, in an amount effective to improve the wear resistance of the substrate. Methods for forming these composite structures include a hot-rolling process, a roll-bonding process, or a combination thereof.
US10214798B2 Method for controlling the energy damping of a shape memory alloy with surface roughness
In a method for controlling energy damping in a shape memory alloy, provided is a shape memory alloy having a composition including at least one of: Cu in at least about 10 wt. %, Fe in at least about 5 wt. %, Au in at least about 5 wt. %, Ag in at least about 5 wt. %, Al in at least about 5 wt. %, In in at least about 5 wt. %, Mn in at least about 5 wt. %, Zn in at least about 5 wt. % and Co in at least about 5 wt. %. The shape memory alloy is configured into a structure including a structural feature having a surface roughness and having a feature extent that is greater than about 1 micron and less than about 1 millimeter. Energy damping of the structural feature is modified by exposing the structural feature to process conditions that alter the surface roughness of the structural feature.
US10214785B2 Adeno-associated virus virions with variant capsid and methods of use thereof
The present disclosure provides adeno-associated virus (AAV) virions with altered capsid protein, where the AAV virions exhibit greater infectivity of retinal cells, when administered via intravitreal injection, compared to wild-type AAV. The present disclosure further provides methods of delivering a gene product to a retinal cell in an individual, and methods of treating ocular disease.
US10214784B2 Genetic markers associated with increased fertility in maize
The present invention relates to methods and compositions for identifying, selecting and/or producing a maize plant or plant part having increased fertility. A maize plant or plant part that has been identified, selected and/or produced by any of the methods of the present invention is also provided.
US10214783B2 Endpoint zygosity assay to detect Rf4 gene in maize
A method is provided for determining the zygosity of an Rf4 gene in a corn plant. A method may include performing a first PCR assay, a second PCR assay, quantifying probes used in the first and second PCR assays, and comparing the quantified probes to determine zygosity.
US10214782B2 Methods and kits to identify klebsiella strains
Embodiments of the invention provide a method of detecting one or more strains of Klebsiella pneumoniae. The method may include forming a plurality of mixtures for nucleic amplification. The method can include amplification of specific sequences within the K. pneumonia genome that can provide definitive information to distinguish between one or more types or strains of K. pneumonia.
US10214780B2 Method and means for identification of animal species
The present invention is concerned with a method of rapid identification of a mammalian species origin or mammalian species origins of a sample.
US10214779B2 Method for identification of anti-HIV human miRNA mimics and miRNA inhibitors and anti-HIV pharmaceutical compounds
The present invention relates to methods for the identification of anti-HIV miRNAs and anti-HIV pharmaceutical compounds using high-throughput screening methods, comprising: transfecting reporter cells with a panel of miRNAs, infecting the reporter cells with HIV, screening the cells to identify miRNAs that modulate HIV infection and identifying the specific pathways, nucleic acids and/or polypeptides that are targeted by the miRNAs. The invention further provides for the identification and screening of anti-HIV pharmaceutical compounds having known activity against the specific pathways, nucleic acids and/or polypeptides that are targeted by the miRNAs for efficacy in the treatment of HIV. The invention also provides for the use of miRNA mimics, miRNA inhibitors and pharmaceutical compounds (including oncology drugs and kinase inhibitors) in the treatment and/or prevention of HIV infection.
US10214777B2 Molecular diagnostic test for cancer
Methods and compositions are provided for the identification of a molecular diagnostic test for cancer. The test defines a novel DNA damage repair deficient molecular subtype and enables classification of a patient within this subtype. The present invention can be used to determine whether patients with cancer are clinically responsive or non-responsive to a therapeutic regimen prior to administration of any chemotherapy. This test may be used in different cancer types and with different drugs that directly or indirectly affect DNA damage or repair, such as many of the standard cytotoxic chemotherapeutic drugs currently in use. In particular, the present invention is directed to the use of certain combinations of predictive markers, wherein the expression of the predictive markers correlates with responsiveness or non-responsiveness to a therapeutic regimen.
US10214771B2 DNA amplification and sequencing using DNA molecules generated by random fragmentation
The present invention is directed to methods to prepare a DNA molecule or a plurality of DNA molecules by random fragmentation. In some embodiments, the present invention regards preparing a template for DNA sequencing by random fragmentation. In specific embodiments, the random fragmentation comprises chemical fragmentation, mechanical fragmentation, or enzymatic fragmentation. In further specific embodiments, a universal sequence is attached to the 3′ end of the DNA fragments, such as by ligation of an adaptor sequence or by homopolymeric tailing with terminal deoxynucleotidyltransferase. In other embodiments, a library is prepared with methods of the present invention.
US10214770B2 Compositions and method for measuring and calibrating amplification bias in multiplexed PCR reactions
Compositions and methods are described for standardizing the DNA amplification efficiencies of a highly heterogeneous set of oligonucleotide primers as may typically be used to amplify a heterogeneous set of DNA templates that contains rearranged lymphoid cell DNA encoding T cell receptors (TCR) or immunoglobulins (IG). The presently disclosed embodiments are useful to overcome undesirable bias in the utilization of a subset of amplification primers, which leads to imprecision in multiplexed high throughput sequencing of amplification products to quantify unique TCR or Ig encoding genomes in a sample. Provided is a composition comprising a diverse plurality of template oligonucleotides in substantially equimolar amounts, for use as a calibration standard for amplification primer sets. Also provided are methods for identifying and correcting biased primer efficiency during amplification.
US10214768B2 Coumarin compounds and their uses as fluorescent labels
The present application relates to new coumarin compounds and their uses as fluorescent labels. The compounds may be used as fluorescent labels for nucleotides in nucleic acid sequencing applications.
US10214767B2 Instrument for cassette for sample preparation
A parallel processing system for processing samples is described. In one embodiment, the parallel processing system includes an instrument interface parallel controller to control a tray motor driving system, a close-loop heater control and direction system, a magnetic particle transfer system, a reagent release system, a reagent pre-mix pumping system and a wash buffer pumping system.
US10214764B2 Separation device for use in the separation, characterization and/or identification of microorganisms
The present invention is directed to a separation device or container that can be used in the separation, isolation or pelleting of microorganisms from a test samples known to contain or suspected of containing said microorganisms. Subsequently, the separated, isolated or pelleted microorganism sample can undergo one or more interrogation steps to provide measurements useful for the characterization and/or identification of microorganism. In one aspect of the present invention, the interrogation steps can occur in situ in the separation device or container described herein.
US10214763B2 Method and device for antibiotic susceptibility testing based on fluctuations of electrical resistance in a microchannel
A system and method for antibiotic susceptibility testing efficiently determines whether bacteria are alive or have been killed by antibiotic treatment. The antibiotic susceptibility testing device includes at least one reservoir into which a bacteria solution is introduced and a microfluidic channel connected to the reservoir, wherein the cross-sectional size of the microfluidic channel is selected to be comparable to the size of the bacterium to be tested. Furthermore, the electrical resistance or voltage signal across the microchannel is monitored as bacteria swim into and out of the channel. Alternatively, a small population of bacteria can be immobilized in the microchannel. The resistance or voltage signal fluctuates when the bacteria are alive and moving in and out of the channel or wiggling on the microchannel walls. If the bacteria are dead, they have limited motility and the signal fluctuations are significantly smaller. By monitoring the signal fluctuations, the antibiotic susceptibility testing device can determine whether or not bacteria are alive, thus enabling antibiotic susceptibility testing of bacteria.
US10214761B2 Amino acid derivatives
There are provided amino acid derivatives of formula V and VI as defined herein which are pyrrolysine analogs for use in bioconjugation processes.
US10214758B2 Method and compositions for improved lignocellulosic material hydrolysis
A method of digesting a lignocellulosic material is disclosed. In one embodiment, the method comprises the step of exposing the material to an effective amount of Streptomyces sp. ActE secretome such that at least partial lignocellulosic digestion occurs.
US10214753B2 Chemical engineering processes and apparatus for the synthesis of compounds
The present invention provides methods for producing cannabinoids and cannabinoid analogs as well as a system for producing these compounds. The inventive method is directed to contacting a compound according to Formula I or Formula II with a cannabinoid synthase. Also described is a system for producing cannabinoids and cannabinoid analogs by contacting a THCA synthase with a cannabinoid precursor and modifying at least one property of the reaction mixture to influence the quantity formed of a first cannabinoid relative to the quantity formed of a second cannabinoid.
US10214752B2 Biosynthesis of 1,3-butanediol
This document describes biochemical pathways for producing 1,3-butanediol using a polypetide having β-ketothiolase activity to form a 3-oxo-5-hydroxypentanoyl-CoA intermediate that can be enzymatically converted to 1,3-butanediol, as well as recombinant hosts producing 1,3-butanediol.
US10214750B2 Systems and methods for cell transduction
Systems and methods are disclosed herein for use in transducing, activating, and otherwise treating cells. Cells are introduced into an inner layer of a multi-layered stack that defines at least one flow chamber and a plurality of cell entrainment regions. Vertical flow through the stack entrains the cells in the cell entrainment regions along with genetic information introduction agents or other additives, before the cells are washed using a reverse vertical flow and are collected from the device.
US10214749B2 Methods of increasing abiotic stress tolerance and/or biomass in plants and plants generated thereby
Isolated polynucleotides having a nucleic acid sequence at least 80% homologous to SEQ ID NO:1, 3, 5, 7, 9, 11, 158, 159, 160, 161, 162-204, 206-211, 214-287 and/or encoding polypeptides having an amino acid sequence at least 80% homologous to SEQ ID NO: 2, 4, 6, 8, 10, 12, 13-56, 58-63, 66-121, 141-156 or 157 are provided. Also provided are methods of utilizing same for increasing the tolerance of a plant to abiotic stresses and/or increasing the biomass, vigor and/or yield of a plant.
US10214740B2 Recombinant fusion proteins and libraries from immune cell repertoires
Disclosed herein are methods and compositions for generating a repertoire of recombinant fusion polypeptides from immune cells, and uses thereof.
US10214739B2 RNA binding solution
The subject innovation relates to a RNA binding buffer comprising (a) at least one chaotropic agent; and (b) an organic solvent selected from the group consisting of ethylene carbonate, ethylene glycol diacetate and 2-pyrrolidone or combinations thereof. The subject innovation further relates to a method of binding RNA to a solid support and to a method of isolating RNA both making use of the binding buffer of the subject innovation. The subject innovation finally relates to a kit comprising the RNA binding buffer or the organic solvent as relevant substance therein.
US10214738B2 Production of high purity chondroitinase ABC
The present invention provides a method for purifying Chondroitinase ABC (ChABC). The present method includes using a heparin-immobilized affinity chromatography column, and through chromatography method obtaining a purified ChABC from a matrix containing the ChABC. The present method is capable of obtaining ChABC in high purity with the advantages of simplicity in preparation and high yield.
US10214736B2 Mutant polypeptides and uses thereof
The present disclosure provides novel polypeptides with 3-buten-2-ol dehydratase activity, polypeptides with catalytic activity in the conversion of 3-methyl-3-buten-2-ol to isoprene, and crystal structure data for one of such polypeptides. Methods of making and using the polypeptides and their related crystal structure data are also provided.
US10214731B2 Adeno-associated virus mediated delivery of C1E1 as a therapy for angioedema
This invention is directed to a vector which comprises a promoter operably linked to a nucleic acid sequence encoding the human C1 esterase inhibitor or Factor XII. The invention is also directed to a composition comprising the vector and a method of using the vector to treat or prevent hereditary angioedema.
US10214728B2 Pancreatic endocrine cells, method for producing same, and transdifferentiation agent
A method for producing pancreatic endocrine cells, the method including introducing one or more genes of a GLIS family or one or more gene products thereof and a Neurogenin3 gene or one or more gene products thereof into somatic cells.
US10214727B2 Platelet-rich plasma compositions and methods of preparation
Methods of preparing platelet-rich plasma (PRP) compositions are disclosed which include adding CD34+ cells to the PRP composition. In addition, the concentration of stromal-derived factor-1 (SDF-1) in the PRP composition may be adjusted to a pre-determined value. The compositions may have elevated levels of white blood cells but reduced levels of neutrophils. Compositions produced by the method are also disclosed.
US10214725B2 Methods and compositions for somatic cell proliferation and viability
Methods and compositions for somatic cell proliferation as well as increasing viability of somatic cells are provided. The compositions include heparin binding protein isolated from a medium conditioned by growth of pluripotent stem cells, such as, human embryonic stem cells, human embryonic carcinoma cells. The methods include contacting a somatic cell with a heparin binding protein composition for a sufficient period of time to provide for enhanced proliferation and/or viability of the somatic cell as compared to the absence of the heparin binding protein composition.
US10214721B2 Method for making culture medium
A method for making a culture medium for culturing neural cells is provided. An original carbon nanotube structure is provided. The original carbon nanotube structure includes a drawn carbon nanotube film including a number of carbon nanotubes joined end to end by van der Waals force. The carbon nanotubes are substantially oriented along the same direction. A carbon nanotube structure including a number of carbon nanotube wires spaced from each other is formed by treating the original carbon nanotube structure. The carbon nanotube structure is fixed on a substrate.
US10214720B2 Low rigidity gels for MSC growth modulation
This invention provides gels and matrices having a rigidity in the range of 0.1-2.5 kPa, methods of manufacturing same, and method of preserving a mesenchymal stem cell population or studying mesenchymal stem cells, comprising same.
US10214719B2 Method of culturing Antrodia cinnamomea with high triterpenoids
A method of culturing Antrodia cinnamomea with high Triterpenoids includes mixing a malt extract, glucose, peptone, agar, and a mushroom's extract with distilled water to obtain a culture medium; providing the culture medium to a high-pressure sterilization machine for sterilization to obtain a sterilized culture medium; providing the sterilized culture medium to an incubator in a disinfection environment to obtain a solidified culture medium after a predetermined time; transplanting Antrodia cinnamomeas strains to the solidified culture medium at separated positions; and exposing the solidified culture medium under a beam.
US10214716B2 Method and apparatus for continuous automated perfusion system harvesting from in-situ filtration probe
An apparatus and method for determining fluid flow (e.g., sterile media flow, filtrate flow, etc.) through tubing is provided. The apparatus includes an air source, a flow valve, a first sensor, a second sensor, and a media tubing section extending between the first sensor and the second sensor. In operation, air from the air source is introduced by the flow valve into a fluid flow to create a lead line of fluid immediately following the introduced air. As the lead line of fluid passes each sensor, the sensors are used to determine a time between when the lead line passes the first sensor and the second sensor and that determined elapsed time is used, along with a determined volume of the media tubing section to determine the rate of flow of the fluid flow.
US10214713B2 Apparatuses and methods for high-throughput protein synthesis
The current is directed to a device comprising, a reaction chamber where a reaction takes place, one or more feeding chambers which contain feeding solution comprising chemicals required for the reaction, and one or more porous membranes separating the reaction chamber from the one or more feeding chambers, and wherein the one or more porous membranes are in substantially vertical position. The current invention is also directed to an apparatus comprising a plurality of devices, wherein each device comprises of a reaction chamber where a reaction takes place, one or more feeding chambers which contain feeding solution comprising chemicals required for the reaction, and one or more porous membranes which separate the reaction chamber from feeding chambers, wherein the one or more porous membranes are in substantially vertical position. These devices and apparatuses can be used for high throughput synthesis of biomolecules and chemicals and biological screening assays.
US10214710B2 Intercalated bleach compositions, related methods of manufacture and use
The invention relates to compositions, methods of use, and methods of manufacture for an intercalated bleach compound and compositions thereof. The intercalated bleach compound has the formula Mx(OCl)y(O)m(OH)n where M is an alkaline earth metal such as magnesium, calcium or mixture thereof. The values of x and y independently equal any number greater than or equal to 1 (e.g., 1, 2, 3, 4, etc.), and m and n independently equal any number greater than or equal to 0 (e.g., 0, 1, 2, 3, 4, etc.), but m and n are not both 0. In addition, the molar ratio of the alkaline earth metal (e.g., magnesium or calcium) to hypochlorite is at least 3:1. In other words, x is ≥3y. The compounds exhibit excellent stability, little or no chlorine bleach odor, exhibit excellent pH buffering characteristics, and less reactivity with organic materials as compared to alternative chlorine bleach products.
US10214704B2 Anti-degradation and self-healing lubricating oil
A lubricating oil comprises a base oil; and an anti-degradation additive comprising microcapsules, nanocapsules, or a combination comprising at least one of the foregoing; the microcapsules and the nanocapsules each independently having a core of a neutralizing material and a polymeric encapsulant configured to release the neutralizing material in an acidic environment by breaking crosslinks or hydrogen bonds in the polymeric encapsulant. The released neutralizing material can prevent the formation of viscous, high molecular weight molecules thus enhancing the lifetime of the lubricating oil and improving its reliability.
US10214697B2 Process for removing sulphur compounds from hydrocarbons
The present disclosure relates to a process for reducing the sulphur content of hydrocarbon feedstocks such as Natural Gas Condensate, Kerosene, Jet Fuel, Diesel, Vacuum Gas Oil and Fuel Oil. The process uses a tailored oxidation process comprising one or two oxidation steps to produce sulphoxides and/or sulphones. These sulphoxides and sulphones, while being still present in the liquid hydrocarbon streams, are subsequently extracted thereby producing a low sulphur hydrocarbon stream and optionally following further treatment of the sulphoxides and/or sulphones, produce a low sulphur aromatic hydrocarbon stream and an aqueous stream of sodium sulphite or sulphuric acid. The low sulphur hydrocarbon stream and low sulphur aromatic hydrocarbon stream may be individually recycled or combined for recycling.
US10214695B2 Process for recovering heat from a hydrocarbon separation
A process for recovering heat from the separation of hydrocarbons. The overhead vapor stream from a fractionation column is passed to a two stage heat pump compressor. The first stage of compression is used to reboil the fractionation column. The second stage is compressed and cooled passed to a separation zone. The liquid in the separation zone may be passed back to the fractionation column as secondary reflux, and/or recovered as liquid product. Heat may also be removed from the second stage. A suction drum on the first stage may be used to protect the heat pump compressor from any droplets in the overhead stream.
US10214694B2 Configuration in single-loop synfuel generation
This invention relates to a new process to directly produce transportation gasoline from synthesis gas containing principally carbon monoxide, carbon dioxide, and hydrogen. The process entails three sequential catalytic stages with intermediate heat exchange to provide the requisite temperature in each stage, but with no interstage separation. The recycle loop enhances the conversion of the synthesis gas to the desired products and also serves as heat sink for the highly exothermic reactions involved in each stage.
US10214693B2 Flame-retardant vanillin-derived small molecules
A flame-retardant vanillin-derived small molecule, a process for forming a flame-retardant polymer, and an article of manufacture comprising a material that contains the flame-retardant vanillin-derived small molecule are disclosed. The flame-retardant vanillin-derived small molecule can be synthesized from vanillin obtained from a bio-based source, and can have at least one phosphoryl or phosphonyl moiety with phenyl, allyl, or thioether substituents. The process for forming the flame-retardant polymer can include reacting a diol vanillin derivative and a flame-retardant phosphorus-based molecule to form the flame-retardant vanillin-derived small molecule, and binding the flame-retardant vanillin-derived small molecule to a polymer. The material in the article of manufacture can be flame-retardant, and contain the flame-retardant vanillin-derived small molecules. Examples of materials that can be in the article of manufacture can include resins, plastics, adhesives, polymers, etc.
US10214690B2 Liquid crystal composition and a liquid crystal display including the same
A liquid crystal composition including a liquid crystal compound represented by Formula 1:
US10214687B2 Method for producing and method for processing complex fluoride phosphor
Provided is a method for producing a red phosphor which is a Mn-activated complex fluoride represented by formula (1), A2MF6:Mn (1) (M is one type or more of a tetravalent element selected from Si, Ti, Zr, Hf, Ge, and Sn, and A is one type or more of an alkali metal selected from Li, Na, K, Rb, and Cs, and includes at least Na and/or K.), wherein, as a reactive source, a solid of a complex fluoride represented by formula (2), A2MF6 (2) (M and A are as described above) and a solid of a manganese compound represented by formula (3), A2MnF6 (3) (A is as described above) are mixed and heated at a temperature of from 100° C. to 500° C. According to the present invention, a Mn-activated complex fluoride phosphor having favorable luminescence properties can be obtained without using hydrofluoric acid in a main step.
US10214684B2 Friction reducers and well treatment fluids
The present invention relates to friction reducers and to well treatment fluids. In one embodiment there is provided a friction reducing composition comprising (a) a phosphonium compound and (b) a polymeric friction reducer. In a further embodiment there is provided a well treatment fluid comprising a phosphonium compound.
US10214671B2 Refrigerator oil and working fluid composition for refrigerator
The working fluid composition for a refrigerating machine of the invention is characterized by comprising an ester of a polyhydric alcohol and a fatty acid with a content of a C5-C9 branched fatty acid of 50-100% by mole, and a fluoropropene refrigerant and/or trifluoroiodomethane refrigerant. The refrigerating machine oil of the invention is characterized by comprising an ester of a polyhydric alcohol and a fatty acid with a content of a C5-C9 branched fatty acid of 50-100% by mole, and by being used together with a fluoropropene refrigerant and/or trifluoroiodomethane refrigerant.
US10214669B2 Compositions comprising 2,3-dichloro-1,1,1-trifluoropropane, 2-chloro-1,1,1-trifluoropropene, 2-chloro-1,1,1,2-tetrafluoropropane or 2,3,3,3-tetrafluoropropene
Disclosed are compositions comprising HCFC-243db, HCFO-1233xf, HCFC-244db and/or HFO-1234yf and at least one additional compound. For the composition comprising 1234yf, the additional compound is selected from the group consisting of HFO-1234ze, HFO-1243zf, HCFC-243db, HCFC-244db, HFC-245cb, HFC-245fa, HCFO-1233xf, HCFO-1233zd, HCFC-253fb, HCFC-234ab, HCFC-243fa, ethylene, HFC-23, CFC-13, HFC-143a, HFC-152a, HFC-236fa, HCO-1130, HCO-1130a, HFO-1336, HCFC-133a, HCFC-254fb, HCFC-1131, HFO-1141, HCFO-1242zf, HCFO-1223xd, HCFC-233ab, HCFC-226ba, and HFC-227ca. Compositions comprising HCFC-243db, HCFO-1233xf, and/or HCFC-244db are useful in processes to make HFO-1234yf. Compositions comprising HFO-1234yf are useful, among other uses, as heat transfer compositions for use in refrigeration, air-conditioning and heat pump systems.
US10214656B2 Copper nanoparticles and production method for same, copper nanoparticle fluid dispersion, copper nanoink, copper nanoparticle preservation method, and copper nanoparticle sintering method
An object of the present invention is to provide copper nanoparticles that suppress the oxidation of copper, have an average particle diameter of 10 nm or less and therefore undergo a remarkable reduction in the melting point, are highly dispersible, can be sintered at a low temperature, allow the removal of the protective layer during low-temperature sintering at 150° C. or less, and can be suitably used as a conductive copper nanoink material; and to also provide a method for preserving copper nanoparticles, whereby the copper nanoparticles can be stably preserved at room temperature for a long period of time, and can be transported.The present invention provides copper nanoparticles each having a central portion comprising a copper single crystal, and a protective layer surrounding the central portion; (1) the copper nanoparticles having an average particle diameter of 10 nm or less; (2) the protective layer containing at least one member selected from the group consisting of C3-6 primary alcohols, C3-6 secondary alcohols, and derivatives thereof; and (3) the protective layer having a boiling point or thermal decomposition point of 150° C. or less.
US10214653B2 Refractory article and production method thereof
The present invention provides a refractory article which is fire resistant, heat resistant, and light weight, and which is suitable for use as a building material. The refractory article comprises (1) a core material and (2) a refractory layer which covers one or more surface of the core material, and comprises a polyisocyanurate resin. The core material (1) may be a glued laminated timber. Suitable polyisocyanurate resins may be obtained by reaction of a polyisocyanate in the presence of a polyol. A flame retardant may be present in the polyisocyanurate resin.
US10214649B2 High content polyamide hot-applied thermoplastic composition
A hot-applied thermoplastic pavement marking composition comprising a modified polyamide resin in the range of between 3 and 10 percent by weight, rosin-modified esters, a copolymer, 30-70 percent by weight of a glass bead intermix, a range of between 1 and 15 percent by weight of either white or yellow pigment, and one or more plasticizers, inorganic fillers, waxes, antioxidants or light stabilizers, and methods of applying a hot-applied thermoplastic pavement marking composition.
US10214646B2 Warm mix paving composition w/lubricating antistrip additive
The present invention provides an asphalt paving composition including an essentially water-free, non-foamed warm mix asphalt binder composition modified with lubricating antistrip additives that can be mixed with uncompacted aggregate to provide a warm mix paving composition of the aggregate adequately coated with the essentially water-free, non-foamed binder and lubricating antistrip additive. This warm mix paving composition may be mixed at temperatures of 280° F. or lower and may be compacted at temperatures of 260° F. or lower that are below mixing and compacting temperatures of similar paving compositions that do not contain the disclosed lubricating antistrip additives.
US10214644B2 Dark polycarbonate composition
Polycarbonate blends with a combination of high thin wall flame retardance, low temperature ductility, and good tracking resistance are disclosed. The blends are a combination of a polycarbonate polymer, a polycarbonate-polysiloxane copolymer, non-brominated and non-chlorinated flame retardant, titanium dioxide, and carbon black.
US10214641B2 Aqueous organic silicon fluoro-containing polymer dispersion and method for manufacturing the same
An aqueous organic silicon fluoro-containing polymer dispersion is provided. The dispersion includes 100 parts by weight of poly(vinylidene difluoride-hexafluoropropylene), 10 to 30 parts by weight of organic silicon emulsion, and acrylate polymer. The acrylate polymer and the sum of the poly(vinylidene difluoride-hexafluoropropylene) and the organic silicon emulsion have a weight ratio of 30:100 to 50:100.
US10214639B2 Post consumer recycled resin composition and manufacture of tubes therefrom
The present disclosure relates to a post consumer recycled polymer composition comprising: 80% to 95% (w/w) of a post consumer recycled resin; and 5% to 20% (w/w) of at least one additive. The present disclosure further relates to a laminate comprising: an outer layer of a post consumer recycled polymer composition; a middle layer of post consumer recycled polymer composition; and an inner layer of virgin resins. The present disclosure also relates to a process for manufacturing tubes comprising: extrusion of post consumer recycled polymer composition comprising 80% to 95% (w/w) of an post consumer recycled resin; and 5% to 20% (w/w) of at least one additive, through a circular slit to form a long cylindrical hollow pipe; slicing the long cylindrical hollow pipe to form tube sleeves; forming tube shoulder and neck; and attaching the tube shoulder and the neck to the tube sleeves to obtain a tube.
US10214636B2 Rubber composition for a tire tread
A rubber composition for a tire tread includes 6 to 20 parts by weight of a silane coupling agent having a mercapto group and SiO bond; and 1 to 20 parts by weight of terpene resin having a softening point of 130° C. or more and a weight average molecular weight of 1,000 or more, to 100 parts by weight of raw rubber.
US10214634B2 Articles formed with biodegradable materials and strength characteristics of same
Described herein are strength characteristics and biodegradation of articles produced using one or more petrochemical-based polymers and one or more carbohydrate-based polymers. A compatibilizer can optionally be included in the article. In some cases, the article can include a film or bag.
US10214633B2 Tire with tread intended for off-the-road service
This invention relates to heavy duty pneumatic rubber tires with treads intended for use on diverse surfaces, particularly for off-the-road service.
US10214632B2 Crystallinity modifier for polyolefins
The present invention relates to a novel and economical process for modification of acid scavenger to be used not only for neutralizing the effect of catalyst residue but as well as crystallinity modifier in polyolefins. More particularly, the present invention discloses a process for modification of acid scavenger to be used as dual functional additive as acid scavenger as well as crystallinity modifier in polyolefins, said process comprising treating an acid scavenger with an organic dibasic acid to obtain a modified acid scavenger, wherein the acid scavenger is calcium aluminum hydroxy carbonate having chemical formula Ca4Al2(OH)12CO3.nH2O, where n=4-5.
US10214628B2 Plasticizer blends and plastisol compositions comprised thereof
A novel plasticizer blend(s) useful for plastisol compositions, including organisols, having good solvating properties, good viscosity profiles and compatibility with other plasticizers and solvents traditionally used in plastisols, comprising benzoate ester plasticizer(s) and a compatibilizing plasticizer component. Methods for preparing a plastisol having low viscosity and good rheology characteristics and for rendering a benzoate ester plasticizer, or blends thereof, compatible with organic solvents traditionally used in plastisols, by incorporating the novel plasticizer blend(s), which do not require adjusting the solubility parameters of the solvents to accommodate the plasticizer, are disclosed.
US10214624B2 Apparatus and method for expanding thermally expandable thermoplastic microspheres to expanded thermoplastic microspheres
An apparatus and a method for expanding a slurry of thermally expandable thermoplastic microsphere is disclosed. The apparatus and method expand the slurry of thermally expandable thermoplastic microsphere without any direct contact to a fluid heat transfer medium. The apparatus and method utilize a distribution pipe attached to an outlet pipe.
US10214620B2 Nano-reinforcement filler material for epoxy resin systems and methods of making the same
A method of making a nano-reinforcement filler material for an epoxy resin system for a composite structure is provided. The method includes forming a polymer suspension of polymer nanoparticles suspended in deionized (DI) water, and sonicating the polymer suspension. The method includes forming a graphene oxide (GO) suspension of GO sheets suspended in DI water, and sonicating the GO suspension. The method includes mixing the sonicated polymer suspension and the sonicated GO suspension to obtain a sonicated mixture. The method includes heating the sonicated mixture in an inert atmosphere at an effective temperature, and using an electrostatic process to uniformly wrap individual polymer nanoparticles with individual GO sheets, via an electrostatic interaction reaction, to obtain the nano-reinforcement filler material comprising polymer-GO core-shell nanoparticles. The method includes washing and drying the nano-reinforcement filler material, and using it in the epoxy resin system for the composite structure.
US10214617B1 Dissolving tire rubber
A method for generating a dissolving rubber compound in asphalt is described. The method includes receiving an asphalt compound and heating the asphalt compound to approximately 320° F. to 420° F. The method then proceeds to add a tire rubber compound to the asphalt compound. The asphalt compound and the tire rubber compound are mixed for approximately 5 minutes to 240 minutes. The dissolved rubber compound is generated by heating a mixture of the asphalt compound and the tire rubber to approximately 525° F.-700° F. The dissolved rubber compound is then cooled.
US10214613B2 Polyester resins based on fatty acids that have a short oil length, aqueous dispersions and associated coatings
The invention relates to a polyester resin which is based on at least one fatty acid, with zero oil length (0%) or an oil length of between 0 and 35%, with a weight ratio of oxidizable fatty acids (monoacids), relative to the overall fatty acids, of 0 or greater than 0 and ranging up to 1, and which is based on an acid component comprising, in addition to the fatty acid, from 30% to 85% by weight, relative to the total weight of said resin, of rosin and/or of derivatives thereof bearing at least one carboxylic acid function.
US10214609B2 Polyglyoxylates, manufacture and use thereof
Self-immolative polymers degrade by an end-to-end depolymerization mechanism in response to the cleavage of a stabilizing end-cap from the polymer terminus. Examples include homopolymers, mixed polymers including block copolymers, suitable for a variety of applications. A polyglyoxylate can be end-capped or capped with a linker as in a block copolymer.
US10214605B2 Method for producing polycarboxylic acid polymer
Provided is a method of producing a polycarboxylic acid-based polymer, the method including adding a monomer composition containing an unsaturated monocarboxylic acid-based monomer and/or an unsaturated dicarboxylic acid-based monomer to a reaction vessel to perform a polymerization reaction, which enables effective suppression of the foaming of a polymerization reaction liquid. The method of producing a polycarboxylic acid-based polymer of the present invention is a method of producing a polycarboxylic acid-based polymer, the method including adding a monomer composition containing an unsaturated monocarboxylic acid-based monomer and/or an unsaturated dicarboxylic acid-based monomer to a reaction vessel to perform a polymerization reaction, the method further including adding a defoaming agent by a time when 100 mass % of a total amount of the monomer composition is added.
US10214602B2 Polymerization process for producing ethylene based polymers
The instant invention provides a polymerization process for producing ethylene based polymers.In one embodiment, the instant invention provides a polymerization process for producing ethylene based polymers comprising: polymerizing ethylene with optionally one or more α-olefins in the presence of one or more first catalyst systems and optionally one or more second catalyst systems in a single reactor, wherein first catalyst system comprises; (a) one ore more procatalysts comprising a metal-ligand complex of formula (I):
US10214598B2 (Meth)acrylate compound, and copolymer and homopolymer comprising repeating unit derived from same
The present specification relates to a (meth)acrylate compound, and a copolymer and a homopolymer including a repeating unit derived therefrom.
US10214595B2 Nanocellulose compositions and processes to produce same
A composition comprising nanocellulose is disclosed, wherein the nanocellulose contains very low or essentially no sulfur content. The nanocellulose may be in the form of cellulose nanocrystals, cellulose nanofibrils, or both. The nanocellulose is characterized by a crystallinity of at least 80%, an onset of thermal decomposition of 300° F. or higher, and a low light transmittance over the range 400-700 nm. Other variations provide a composition comprising lignin-coated hydrophobic nanocellulose, wherein the nanocellulose contains very low or essentially no sulfur content. Some variations provide a composition comprising nanocellulose, wherein the nanocellulose contains about 0.1 wt % equivalent sulfur content, or less, as SO4 groups chemically or physically bound to the nanocellulose. In some embodiments, the nanocellulose contains essentially no hydrogen atoms (apart from hydrogen structurally contained in nanocellulose itself) bound to the nanocellulose. Various compositions, materials, and products may incorporate the nanocellulose compositions disclosed herein.
US10214592B2 Protein assay method specific to TRACP-5b (tartrate resistant acid phosphatase 5b)
The purpose of the present invention is to provide a monoclonal antibody that is useful in specifically assaying tartrate resistant acid phosphatase 5b (TRACP-5b). A hybridoma producing a monoclonal antibody against TRACP-5b, said monoclonal antibody showing higher reactivity with TRACP-5b than with tartrate resistant acid phosphatase 5a (TRACP-5a) and, therefore, being specific to TRACP-5b, is obtained by cell fusion using, as an antigen, human recombinant TRACP-5b purified from silkworm silk gland. By using this monoclonal antibody, TRACP-5b in a specimen can be highly sensitively and specifically detected.
US10214590B2 Inhibitors of endoglin activity for the treatment of fibrosis
Endoglin has been identified to play a functional role as a regulator of TGFβ1 signaling, particular in TGFβ1-mediated calcineurin expression. The present invention features methods of reducing cardiac damage, particularly in a subject undergoing chemotherapy or radiation therapy by administering a composition that inhibits endoglin activity. The present invention also features methods of treating autoimmune diseases, inflammatory diseases, organ transplantation, and conditions association with oxidative stress related to TGFβ1-mediated calcineurin expression and reactive oxygen species (ROS) production by administering a composition that inhibits endoglin activity. The present invention also features methods of treating fibrotic diseases by administering a composition that inhibits endoglin activity.
US10214588B2 Providing improved immunoglobulin sequences by mutating CDR and/or FR positions
The present invention relates to methods and techniques for providing improved amino acid sequences that can be used as single antigen-binding domains. In particular, the invention relates to methods and techniques for providing improved amino acid sequences that can be used as single antigen-binding domains that comprise or essentially consist of at least one immunoglobulin sequence. More in particular, the amino acid sequences provided herein may comprise or essentially consist of at least one variable domain sequence or a suitable fragment thereof such as at least one light chain variable domain sequence (e.g. a VL-sequence) or a suitable fragment thereof or at least one heavy chain variable domain sequence (e.g. a VH-sequence or VHH sequence) or a suitable fragment thereof.
US10214577B2 Peptides and combination of peptides for use in immunotherapy against esophageal cancer and other cancers
The present invention relates to peptides, proteins, nucleic acids and cells for use in immunotherapeutic methods. In particular, the present invention relates to the immunotherapy of cancer. The present invention furthermore relates to tumor-associated T-cell peptide epitopes, alone or in combination with other tumor-associated peptides that can for example serve as active pharmaceutical ingredients of vaccine compositions that stimulate anti-tumor immune responses, or to stimulate T cells ex vivo and transfer into patients. Peptides bound to molecules of the major histocompatibility complex (MHC), or peptides as such, can also be targets of antibodies, soluble T-cell receptors, and other binding molecules.
US10214574B2 Engineered calmodulin for treatment of ryanopathies
Compositions and methods are disclosed for altering the binding affinity of calmodulin for ryanodine receptor 2 (RyR2). As disclosed herein, these therapeutic calmodulin (TCaM) proteins can be used to correct ryanopathies by prolonging the RyR2 refractory period. Therefore, also disclosed is a method for treating a ryanopathy-associated disease in a subject that involves administering to the subject a composition comprising a TCaM disclosed herein.
US10214573B2 Biglycan variant polypeptides and methods of use
The invention provides compositions and methods for treating, preventing, and diagnosing diseases or conditions associated with an abnormal level or activity of biglycan; disorders associated with an unstable cytoplasmic membrane, due, e.g., to an unstable dystrophin associated protein complex (DAPC); disorders associated with abnormal synapses or neuromuscular junctions, including those resulting from an abnormal MuSK activation or acetylcholine receptor (AChR) aggregation. Examples of diseases include Amyotrophic Lateral Sclerosis (ALS), as well as muscular dystrophies, such as Duchenne's Muscular Dystrophy, Becker's Muscular Dystrophy, neuromuscular disorders and neurological disorders.
US10214572B2 Dual-AAV vector-based systems and methods for delivering oversized genes to mammalian cells
Disclosed are materials and methods for treating diseases of the mammalian eye, and in particular, Usher syndrome 1B (USH1B). The invention provides AAV-based, dual-vector systems that facilitate the expression of full-length proteins whose coding sequences exceed that of the polynucleotide packaging capacity of an individual AAV vector. In one embodiment, vector systems are provided that include i) a first AAV vector polynucleotide that includes an inverted terminal repeat at each end of the polynucleotide and a suitable promoter followed by a partial coding sequence that encodes an N-terminal portion of a full-length polypeptide; and ii) a second AAV vector polynucleotide that includes an inverted terminal repeat at each end of the polynucleotide and a partial coding sequence that encodes a C-terminal portion of a full-length polypeptide, optionally followed by a polyadenylation (pA) signal sequence. In another embodiment, the vector system includes i) a first AAV vector polynucleotide comprising an inverted terminal repeat at each end, a suitable promoter followed by a partial coding sequence that encodes an N-terminal portion of a full-length polypeptide followed by a splice donor site and intron and ii) a second AAV vector polynucleotide comprising an inverted terminal repeat at each end, followed by an intron and a splice-acceptor site for the intron, followed by a partial coding sequence that encodes a C-terminal portion of a full-length polypeptide, optionally followed by a polyadenylation (pA) signal sequence. The coding sequence or the intron sequence in the first and second AAV vectors preferably includes a sequence region that overlaps.
US10214570B2 Specific active site inhibitors of enzymes and methods of producing same
The present disclosure provides a method of producing enzyme-specific inhibitors or substrate binding partners comprising: identifying active site residues of the substrate in the enzyme substrate complex or in substrate binding partner-substrate complex; randomizing the active site residues to produce a combinatorial library of substrate variants; and selecting substrate variants that inhibit enzyme activity or bind substrate as substrate-specific binding partners. The present disclosure also provides ubiquitin enzyme specific inhibitors and ubiquitin variants that bind ubiquitin interaction motifs.
US10214569B2 Fusion proteins and combination vaccines comprising Haemophilus influenzae protein E and pilin A
The present invention relates to compositions comprising Haemophilus influenzae Protein E and Pilin A. More particularly, the present application relates to fusion proteins and immunogenic compositions comprising Protein E and PilA, vaccines comprising such immunogenic compositions and therapeutic uses of the same.
US10214568B2 Method for preparing phycocyanin
Provided is a preparation method for phycocyanin, including: adding chitosan to a suspension of cyanobacteria containing phycocyanin; and filtering the suspension.
US10214565B2 Compositions and methods for treating, including preventing, parvovirus infections and related diseases
Some embodiments of the invention include inventive polypeptides (e.g., mutant VP2 proteins) and virus-like particles made from the inventive polypeptides. Other embodiments of the invention include compositions for treating (e.g., preventing) parvovirus (e.g., erythrovirus or parvovirus B19) infection and other diseases. Further embodiments include methods for administering compositions to an animal. Other embodiments include treating (e.g., preventing) parvovirus (e.g., erythrovirus or parvovirus B19) infection and other diseases. Still other embodiments include nucleic acid sequences that encode the inventive polypeptides. Additional embodiments of the invention are also discussed.
US10214562B2 Peptides and methods of using same
We describe peptides and their uses for the treatment of autoimmune, inflammatory and metabolic diseases.
US10214561B2 Peptide having activity of inhibiting production of toxin by bacterium belonging to genus clostridium
To provide a means for preventing, treating and/or controlling health damages, including food poisoning and infections, caused by a bacterium belonging to the genus Clostridium. The above object can be solved by a cyclic peptide containing the sequence Cys-Phe-Trp-Ala-His and/or a broth of Clostridium butyricum.
US10214559B2 Protein recovery
There is provided a process for producing proteins from the by-product streams arising from distillation processes, in particular the by-product stream known as “pot ale” or “burnt ale” and the use of such proteins as protein feed ingredients or food additives.
US10214549B2 Furan-containing flame retardant molecules
A furan-containing flame retardant molecule includes a furan moiety bonded to a phosphorus moiety via a phosphoryl linkage or via a phosphinyl linkage.
US10214543B2 Synthesis of cephalosporin compounds
Described herein are methods for the manufacture of ceftolozane and related compounds, as well as compositions comprising the same.
US10214542B2 Modified macrocyclic compounds
The present invention relates to novel modified macrocyclic compounds of general formula (I) as described and defined herein, and methods for their preparation, their use for the treatment and/or prophylaxis of disorders, in particular of hyper-proliferative disorders and/or virally induced infectious diseases and/or of cardiovascular diseases. The invention further relates to intermediate compounds useful in the preparation of said compounds of general formula (I).
US10214538B2 Process for preparation of Darunavir
The present invention provides a process for the preparation of darunavir or solvates or a pharmaceutically acceptable salt thereof substantially free of bisfuranyl impurities, particularly darunavir propionate solvate. The present invention also provides a process for preparation amorphous darunavir using the darunavir propionate solvate.
US10214534B2 Substituted 2-phenyl (AZA)benzofuran compounds for the treatment of hepatitis C
Compounds of Formula I, including their salts, as well as compositions and methods of using the compounds are set forth. The compounds have activity against hepatitis C virus (HCV) and may be useful in treating those infected with HCV:
US10214533B2 N-acyl-(3-substituted)-5,6,7,8-tetrahydro-[1,2,4]triazolo[4,3-a]pyrazines as selective NK-3 receptor antagonists, pharmaceutical composition, methods for use in NK-3 receptor-mediated disorders
Novel compounds of Formula I and their use in therapeutic treatments.
US10214529B2 Small molecules for the treatment of primary cancer and cancer metastasis
Certain embodiments and compounds are of the class of non-hydrolysable ATP analogs and adenosine receptor antagonists, useful for inhibiting the migration and growth of cancer cells.
US10214528B2 Bicyclic heterocycles as FGFR4 inhibitors
The present invention relates to bicyclic heterocycles, and pharmaceutical compositions of the same, that are inhibitors of the FGFR4 enzyme and are useful in the treatment of FGFR4-associated diseases such as cancer.
US10214527B2 Triazolopyridine inhibitors of myeloperoxidase
The present invention provides compounds of Formula (I): wherein A is as defined in the specification, and compositions comprising any of such novel compounds. These compounds are myeloperoxidase (MPO) inhibitors and/or eosinophil peroxidase (EPX) inhibitors, which may be used as medicaments.
US10214526B2 Substituted pyrazolo[1,5-a]-pyridine-3-carboxamides and use thereof
The present application relates to novel substituted pyrazolo[1,5-a]pyridine-3-carboxamides, to processes for their preparation, to their use, alone or in combinations, for the treatment and/or prophylaxis of diseases, and to their use for producing medicaments for the treatment and/or prophylaxis of diseases, in particular for the treatment and/or prophylaxis of cardiovascular disorders.
US10214525B2 Chlorinated napthalenetetracarboxylic acid derivatives, preparation thereof and use thereof in organic electronics
The present invention relates to chlorinated naphthalenetetracarboxylic acid derivatives, preparation thereof and use thereof as charge transport materials, exciton transport materials or emitter materials.
US10214522B2 Anti-alphavbeta1 integrin inhibitors and methods of use
Provided herein, inter alia, are methods and compositions for inhibiting αvβ1 integrin and for treating fibrosis.
US10214520B2 Substituted azaspiro(4.5)decane derivatives
The invention relates to substituted spirocyclic cyclohexane derivatives which have an affinity for the μ opioid receptor and/or the ORL1 receptor, processes for the preparation thereof, medicaments containing these compounds and the use of these compounds for the preparation of medicaments.
US10214517B2 LFA-1 inhibitor and methods of preparation and polymorph thereof
Methods of preparation and purification of a compound of Formula I, intermediates thereof, a polymorph thereof, and related compounds are disclosed. Formulations and uses thereof in the treatment of LFA-1 mediated diseases are also disclosed.
US10214516B2 5-(N-fused tricyclic aryl tetrahydroisoquinolin-6-yl) pyridin-3-yl acetic acid derivatives as inhibitors of human immunodeficiency virus replication
Disclosed are compounds of Formula I, including pharmaceutically acceptable salts, pharmaceutical compositions comprising the compounds, methods for making the compounds and their use in inhibiting HIV integrase and treating those infected with HIV or AIDS.
US10214515B2 Substituted pyrazoles as inhibitors of fibroblast growth factor receptor
An indole derivative as expressed by Formula (I), a preparation method thereof, a pharmaceutical salt, and use thereof as a therapeutic agent, especially as a FGFR inhibitor. Each substituent in Formula (I) has identical definition as specified in the specification.
US10214512B2 Factor XIA inhibitors
The present invention provides a compound of Formula (I) and pharmaceutical compositions comprising one or more said compounds, and methods for using said compounds for treating or preventing thromboses, embolisms, hypercoagulability or fibrotic changes. The compounds are selective Factor XIa inhibitors or dual inhibitors of Factor XIa and plasma Kallikrein.
US10214511B2 Quinazolines as potassium ion channel inhibitors
A compound of formula I wherein A, X, Y, Z, R1 and R24 are described herein. The compounds are useful as inhibitors of potassium channel function and in the treatment and prevention of arrhythmia, IKur-associated disorders, and other disorders mediated by ion channel function.
US10214510B2 N-cycloalkyl-N-(biheterocyclylethylene)-(thio)carboxamide derivatives
The present invention relates to fungicidal N-cycloalkyl-N-(biheterocyclylethylene)carboxamide derivatives and their thiocarbonyl derivatives, their process of preparation and intermediate compounds for their preparation, their use as fungicides, particularly in the form of fungicidal compositions and methods for the control of phytopathogenic fungi of plants using these compounds or their compositions.
US10214509B2 Amino-substituted heterocyclic derivatives as sodium channel inhibitors
The present invention relates to novel aminoindazolyl derivative compounds of Formula (I), the use of said compounds in treating diseases mediated by modulation of voltage-gated sodium channels in particular Nav1.7 AND to compositions containing said derivatives.
US10214508B2 Nitrogen-containing heterocyclic compound
The present invention provides a compound having a cholinergic muscarinic M1 receptor positive allosteric modulator activity and useful as a medicament such as a prophylactic or therapeutic drug for Alzheimer's disease, schizophrenia, pain, sleep disorder, Parkinson's disease dementia, dementia with Lewy bodies and the like, and the like. The present invention relates to a compound represented by the formula (I) or a salt thereof. wherein each symbol is as described in the attached DESCRIPTION.
US10214506B2 Preparation method for 2-((4R,6S)-6-bromomethyl-2-oxo-1,3-dioxane-4-yl)acetate
The present disclosure belongs to the technical field of organic synthesis and particularly relates to a preparation method for 2-((4R,6S)-6-bromomethyl-2-oxo-1,3-dioxane-4-yl)acetate. The 2-((4R,6S)-6-bromomethyl-2-oxo-1,3-dioxane-4-yl)acetate is a key chiral intermediate for preparation of statin antilipemic agents. In the present disclosure, the 2-((4R,6S)-6-bromomethyl-2-oxo-1,3-dioxane-4-yl)acetate is obtained by bromination and cyclization of 3-((substituted oxycarbonyl)oxy)-5-hexenoate as raw material with hypochlorite and bromide in an organic solvent in the presence of CO2. The method of the present disclosure has the advantages of readily available raw material, mild reaction conditions, easy operation, low cost, excellent atomic economy and less by-products, and is applicable to industrial production.
US10214502B2 Method of inhibiting apolipoprotein-E expression while increasing expression of at least one of LDL-receptor protein or AbcA1 protein comprising administering a small compound
This invention offers an effective method of decreasing expression of apolipoprotein E and increasing expression of at least one of either LDL-receptor protein or AbcA1 protein including selecting mammalian cells expressing apoE and at least one of either LDL-receptor protein or AbcA1 protein, contacting the mammalian cell with an effective amount of a compound having general formula (I) or general formula (II) in an amount sufficient to decrease expression of the apoE and increase expression of at least one of the LDL-receptor protein or the AbcA1 protein in the mammalian cell.
US10214499B2 Dilute chemical reaction process with membrane separation step
Disclosed is a process for carrying out a cyclization reaction, a polymerization reaction, an enzymatic reaction showing substrate inhibition, an enzymatic reaction showing product inhibition, a reaction showing precipitation of the substrate or of a reactant, the process comprising the steps of a) diluting a fresh substrate with solvent to form a diluted substrate-solvent mixture, and supplying this mixture to a reactor, b) causing the reaction medium in the reactor to react, c) discharging reaction mixture comprising reaction product, solvent, and substrate that has not reacted, to a first filtration membrane which is permeable to the solvent and impermeable to the substrate and to the catalyst or at least one of the reactants, d) returning solvent from the permeate side of the first membrane to dilute the fresh substrate, and e) returning retentate comprising substrate which has not reacted, from the first filtration membrane to the reactor.
US10214494B2 Backfunctionalized imidazolinium salts and NHC carbene-metal complexes
Backfunctionalized imidazolinium salts and methods of synthesizing the same and NHC carbene-metal complexes therefrom. For backfunctionalized imidazolinium salts of the formula: Wherein R1 is selected from the group consisting of an ester group, an amide group, and an aromatic group; R2 is selected from the group consisting of hydrogen, an ester group, an amide group, and an aromatic group; R3 and R4 are each an aliphatic group; and X is an anion; the method comprises cyclization of a halogenated acrylate with Hünig's base in a solvent.
US10214493B2 Indazole derivatives useful as glucagon receptor antagonists
The present invention is directed to indazole derivatives, pharmaceutical compositions containing them and their use in the treatment and/or prevention of disorders and conditions ameliorated by antagonizing one or more glucagon receptors, including for example metabolic diseases such as Type II diabetes mellitus and obesity.
US10214491B2 Activators and therapeutic applications thereof
The invention presents methods of identifying small molecule compounds that are activators of tumor suppressor protein p53 pathway, and its associated family members p63 and p73, function. The invention is further drawn to methods of killing tumor cells and treating cancers or other conditions requiring activation of the p53 family member pathways and DNA damage response pathways with the small molecules.
US10214486B2 Process and reactor system for oxidizing cycloalkylbenzene
Disclosed are processes and systems for oxidizing cycloalkylbenzene such as cyclohexylbenzene to make an oxygenate such as a hydroperoxide thereof. A liquid distributor having multiple liquid ingress ports is used for supplying a cycloalkylbenzene-containing liquid into an oxidation reactor in the form of liquid streams forming part of the reaction medium. A gas distributor distributing an O2-containing gas into the reaction medium in the form of gas streams is preferably located below the liquid distributor. Preferably the gas bubbles upwards in the reaction medium. The agitation and mixing provided by the liquid streams, gas streams/bubbles result in sufficient homogeneity of cycloalkylbenzene concentration, cycloalkylbenzene hydroperoxide concentration, dissolved oxygen concentration, and temperature in the liquid phase.
US10214484B2 Method for preparing acrolein cyanohydrins
The present invention relates to an improved method for preparing acrolein cyanohydrins from hydrocyanic acid and the corresponding acroleins. The method is characterized in that the acrolein cyanohydrins obtained have a very low hydrocyanic acid content or are free of hydrocyanic acid and are therefore particularly well suited as intermediates for the synthesis of glufosinates.
US10214483B2 Titanium-silicalite molecular sieve, method for preparing the same and method for preparing cyclohexanone oxime using the molecular sieve
The present invention provides a titanium-silicalite molecular sieve and a method for preparing the same. The method includes the steps of preparing a mixture of a titanium source, a silicon source, a metal source selected from IIA to IVA elements and a template agent; heating the mixture to form a gel mixture; heating the gel mixture in a water bath; and calcining the gel mixture after the gel mixture in the water bath to form the titanium-silicalite molecular sieve. The present invention further provides a method for preparing cyclohexanone oxime by using the titanium-silicalite molecular sieve as the catalyst which results in high conversion rate, high selectivity and high usage efficiency of hydrogen peroxide.
US10214482B2 Diamine having tert-alkylamino group and primary amino group for use in gas scrubbing
A compound of the general formula (I) in which R1, R2 and R3 are independently selected from C1-4-alkyl and C1-4-hydroxyalkyl; each R4 is independently selected from hydrogen, C1-4-alkyl and C1-4-hydroxyalkyl; each R5 is independently selected from hydrogen, C1-4-alkyl and C1-4-hydroxyalkyl; m is 2, 3, 4 or 5; n is 2, 3, 4 or 5; and o is an integer from 0 to 10. A preferred compound of the formula (I) is 2-(2-tert-butylaminoethoxy)ethylamine. Absorbents comprising a compound of the formula (I) have rapid absorption of carbon dioxide from fluid streams and are also suitable for processes for the simultaneous removal of H2S and CO2, where given H2S limits have to be observed but complete removal of CO2 is not required.
US10214480B2 Synthesis process for chiral cyclopropyl ethynyl tertiary alcohol compound
Provided is a synthesis process for a chiral cyclopropyl ethynyl tertiary alcohol compound, where a chiral amino alcohol or a chiral amino diol is reacted in the presence of an alkaline reagent and a salt to obtain an optically active propynyl alcohol compound. In particular, the process includes (1) reacting cyclopropyl acetylene with a chiral inducing agent, a chiral auxiliary reagent and zinc halide in an organic solvent in the presence of an alkaline reagent and a sulfonate or a sulphinate to obtain a first reaction mixture; (2) reacting the resultant first reaction mixture with 5-chloro-2-aminotrifluorobenzophenone to form (S)-2-amino-5-chloro-α-cyclopropyl acetylene-α-trifluoromethylbenzyl alcohol. The process avoids an organic zinc reagent and a Grignard reagent, and has the advantages of safe production, an environmentally friendly route, low production costs, a high resultant product yield, a high chiral ee value and is suitable for industrial production.
US10214479B2 Synthesis of and compositions containing diaminoacetals and diaminoketals
The present invention relates to the reduction of polycyano compounds to produce polyamines, in particular diaminoacetal and diaminoketal compounds, and their use as curing agents in epoxy resin compositions. The reduction with molecular hydrogen can be carried out using a metal catalyst selected from GROUP VIII and a catalytic promoter. The reduction can include anhydrous or aqueous ammonia. The reaction can be carried out in continuous and batch modes with catalyst and solvent recycling. The epoxy resin composition consisting of an epoxy resin and a polyamine curing agent that can be used in fiber-reinforced composite materials, coating materials, and the like.
US10214476B2 Pain relief compounds
The present invention relates to the use of compounds for the treatment or prevention of pain in mammals, in particularly in human beings, and also to a process for preparing these compounds.
US10214468B1 Method for co-production of 1-chloro-3,3,3-trifluoropropene, 2,3,3,3-tetrafluoropropene and 1,3,3,3-tetrafluoropropene
This invention discloses a method for co-production of 1-chloro-3,3,3-trifluoropropene, 2,3,3,3-tetrafluoropropene and 1,3,3,3-tetrafluoropropene. This method includes inputting the mixed gases of hydrogen fluoride and 1,1,1,3,3-pentachloropropane together with 1,1,2,3-tetrachloropropene into a first reactor for a reaction to obtain a reaction product; directly inputting the reaction product into a second reactor to perform a reaction in the presence of a catalyst; separating hydrogen chloride from the obtained product; obtaining 1-chloro-3,3,3-trifluoropropene, 2,3,3,3-tetrafluoropropene and 1,3,3,3-tetrafluoropropene respectively after water washing, alkaline washing, drying and rectifying. This invention has the advantages of flexible production, simple process, small investment, low energy consumption and high conversion rate.
US10214466B2 Systems and methods for producing propylene
According to one embodiment described in this disclosure, a process for producing propylene may comprise at least partially metathesizing a first stream comprising at least about 10 wt. % butene to form a metathesis-reaction product, at least partially cracking the metathesis-reaction product to form a cracking-reaction product comprising propylene, and at least partially separating propylene from the cracking-reaction product to form a product stream comprising at least about 80 wt. % propylene.
US10214465B2 Processes for increasing the overall aromatics and xylenes yield in an aromatics complex
The present subject matter describes processes for increasing overall aromatics and xylenes yield in an aromatics complex. More specifically, the process for increasing overall aromatics and xylenes yield in an aromatics complex accomplishes the increased yields by incorporating an A8-A10 isomerization step into the aromatics complex. This isomerization integration increases the para-xylene.
US10214464B2 Steady state high temperature reactor
A reactor comprising a thermal barrier surrounding a combustion zone. The reactor further comprises a cooling jacket inner wall and a binder disposed between the cooling jacket inner wall and the thermal barrier, and a cooling jacket outer wall, wherein the cooling jacket inner wall and the cooling jacket outer wall define a cooling channel. The reactor further comprises an outer reactor wall disposed over the cooling jacket outer wall, wherein the outer reactor wall is impermeable and is configured to contain high pressure gas within the reactor.
US10214463B2 Production method and production apparatus of α-olefin oligomer
The present invention relates to a production method of an α-olefin oligomer for producing an α-olefin by performing an oligomerization reaction of an α-olefin in a reaction solvent in the presence of a catalyst in a reactor, which is a production method of an α-olefin oligomer, comprising circulating and feeding, to the reactor, a condensate liquid obtained by introducing part of gas of the gas phase part inside the reactor into a heat exchanger and cooling the gas, wherein the condensate liquid circulated and fed to the reactor is dispersed in the gas phase part inside the reactor; and a production apparatus of an α-olefin oligomer.
US10214460B2 Booster composition
An improved ignition and/or booster composition contains a boron-containing constituent such as boron carbide or a metal boride, and, an oxidizer such as potassium perchlorate. A gas generator and a vehicle occupant protection system containing the composition are also included.
US10214457B2 Compositions containing gallium and/or indium and methods of forming the same
A composition is provided that includes a silicon-containing material (e.g., a silicon metal and/or a silicide) and about 0.001% to about 85% of a Ga-containing compound, an In-containing compound, or a mixture thereof. The silicon-based layer can be a bond coating directly on the surface of the substrate. Alternatively or additionally, the silicon-based layer can be an outer layer defining a surface of the substrate, with an environmental barrier coating on the surface of the substrate. A coated component is also provided, as well as a method for coating a ceramic component. Gas turbine engines are also provided that include such a ceramic component.
US10214456B2 Silicon compositions containing boron and methods of forming the same
A composition is generally provided that includes a silicon-containing material (e.g., silicon metal and/or a silicide) and a boron-doped refractory compound, such as about 0.001% to about 85% by volume of the boron-doped refractory compound (e.g., about 1% to about 60% by volume). In one embodiment, a bond coating on a surface of a ceramic component is generally provided with the bond coating including such a composition, with the silicon-containing material is silicon metal.
US10214452B2 Geopolymer foam formulation for a non-flammable, sound-absorbing, thermally insulating geopolymer foam element
A geopolymer foam formulation, comprising at least one inorganic binder selected from the group consisting of latently hydraulic binders, pozzolanic binders and mixtures thereof; at least one alkaline activator selected from the group consisting of alkali metal hydroxides, alkali metal carbonates, alkali metal aluminates, alkali metal silicates and mixtures thereof; at least one surfactant selected from the group consisting of anionic surfactants, cationic surfactants, non-ionic surfactants and mixtures thereof; a gas phase and water. This formulation can also comprise a cement, and also additives for foam stabilization, shrinkage reduction, flexibilization, hydrophobization, or dispersion, fibers and fillers or a mixture thereof, and can be a single-component or two-component formulation. Also, a process for the production of this formulation via foaming by mechanical introduction of air, the use of the formulation for the production of an incombustible, sound-absorbing, thermally insulating geopolymer foam element and the geopolymer foam element.
US10214451B2 Cement and skinning material based on a water-swellable clay, and method for producing segmented or skinned ceramic honeycomb structures
Skins and/or adhesive layers are formed on a porous ceramic honeycomb by applying a layer of a cement composition to a surface of the honeycomb and firing the cement composition. The cement composition contains a water-swellable clay, high aspect inorganic filler particles and water, and are nearly or completely devoid of particles smaller than 100 nm and a cellulosic polymer.
US10214450B2 Hardener composition for addition-polymerisation-based synthetic fixing mortar systems, and the use and production thereof
Hardener composition for an addition-polymerization-curable synthetic fixing mortar system for embedding anchoring means in mortar in holes or crevices, wherein the hardener composition includes oligomeric siloxanes having on average per molecule at least one or preferably two or more organic radicals that carry one or more (secondary or primary) amino and/or thiol groups that react with isocyanate or epoxy groups in the addition reaction and having on average per molecule at least one or more hydrolysable groups, and, in addition, can include one or more further customary additives, to synthetic fixing mortar systems including such a hardener composition, to the use of such synthetic fixing mortar systems for embedding anchoring means in mortar in holes or crevices and to methods of producing and using the synthetic fixing mortar systems and the hardener composition.
US10214449B2 Coating compositions for roofing granules, dark colored roofing granules with increased solar heat reflectance, solar heat-reflective shingles and process for producing the same
Dark colored roofing granules include an inert base particle coated with a composition including a metal silicate, a non-clay latent heat reactant, and a dark colored but solar reflective pigment.
US10214447B2 Coated article including low-emissivity coating, insulating glass unit including coated article, and/or methods of making the same
Certain example embodiments relate to a coated article including at least one infrared (IR) reflecting layer of a material such as silver or the like in a low-E coating, and methods of making the same. In certain cases, at least one layer of the coating is of or includes nickel and/or titanium (e.g., NixTiyOz). The provision of a layer including nickel titanium and/or an oxide thereof may permit a layer to be used that has good adhesion to the IR reflecting layer, and reduced absorption of visible light (resulting in a coated article with a higher visible transmission). When a layer including nickel titanium oxide is provided directly over and/or under the IR reflecting layer (e.g., as a barrier layer), this may result in improved chemical and mechanical durability. Thus, visible transmission may be improved if desired, without compromising durability; or, durability may simply be increased.
US10214446B2 Temperable three layer antireflective coating, coated article including temperable three layer antireflective coating, and/or method of making the same
A coated article includes a temperable antireflection (AR) coating that utilizes medium and low index (index of refraction “n”) layers having compressive residual stress in the AR coating. In certain example embodiments, the coating may include the following layers from the glass substrate outwardly: silicon oxynitride (SiOxNy) medium index layer/high index layer/low index layer. In certain example embodiments, depending on the chemical and optical properties of the high index layer and the substrate, the medium and low index layers of the AR coating are selected to cause a net compressive residual stress and thus optimize the overall performance of the antireflection coating when the coated article is tempered and/or heat-treated.
US10214444B2 Method for treating a surface and device implemented
The present invention relates to a method for treating a surface of an object which comprises the steps consisting of bringing the surface to be treated in contact with a diffusion intermediate and then maintaining said surface to be treated in contact with said diffusion intermediate without any movement relatively to each other, said diffusion intermediate being impregnated with a corrosive solution prior to contacting or during said contacting. The present invention also relates to a device implemented during such a method.
US10214442B2 Vitreous or at least partly crystallised sealing material, joint connection, barrier layer, and layer system comprising the sealing material and integration thereof into components
Vitreous or at least partly crystallized sealing material is provided. The sealing material is from the system SiO2—B2O3—CaO—MgO, which is free from BaO and/or SrO and which has an improved coefficient of thermal expansion and improved crystallization properties. The sealing material is employed to produce joint connections, electrical feedthroughs, and/or as a barrier layer.
US10214440B2 Method for forming a hot glass sheet with transverse curvature
A glass sheet press forming station (32) and method for press forming hot glass sheets with transverse curvature is performed by initially limiting the central forming of a glass sheet (G) between its end portions upon pickup from a roll conveyor to an upper mold (38) and prior to press forming with an associated lower mold (66) to prevent central area optical distortion of the press formed glass sheet.
US10214438B2 Cross current staged reverse osmosis
Systems and processes for purifying and concentrating a liquid feed stream are disclosed. In the systems, the concentrated liquid output from the high pressure side of a reverse osmosis stage is used as the draw solution in the low pressure side of the reverse osmosis stage in a configuration called osmotically assisted reverse osmosis. This reduces the osmotic pressure differential across the membrane, permitting high solute concentrations to be obtained, hastening the purification of the liquid. Reduced system pressures are also obtained by arranging multiple osmotically assisted reverse osmosis stages in a cross-current arrangement. Overall system energy consumption is reduced compared to conventional thermal processes for high concentration streams.
US10214432B2 Method and device for online monitoring of water quality
A method for monitoring quality of a water flow in a pipe, by diverting a flow into a laser particle counter to count particles within a particle size interval in the water, to continuously determine the number of particles within the size interval, comparing the count with a reference value and taking a sample of the water from the pipe when the count exceeds a threshold value, and also diverting a flow of water from the pipe into a unit that separates the flow into fractions, and taking a sample of at least one of said fractions when the count exceeds a threshold value, and also sending an alarm signal when the count exceeds a threshold value. When the count exceeds at threshold value, the water is treated with ozone.
US10214427B2 Molecular sieve SSZ-109, its synthesis and use
A novel synthetic crystalline molecular sieve designated as SSZ-109 is disclosed. SSZ-109 is synthesized using a structure directing agent comprising one or more of N,N,N′,N′-tetramethyl-N,N′-diisobutylhexane-1,6-diammonium cations, N,N,N′,N′-tetramethyl-N,N′-dineopentylhexane-1,6-diammonium cations, and N,N,N′,N′-tetramethyl-N-isobutyl-N′-neopentylhexane-1,6-diammonium cations.
US10214423B2 Preparation of carbon nanotube shell materials
Methods of making a carbon nanotube material and uses thereof are described. The methods can include obtaining a carbon-containing polymeric matrix shell having a single discrete void space defined by the carbon-containing polymeric matrix shell or having an encapsulated core and subjecting the carbon-containing polymeric matrix shell to a graphitization process to form a shell having a carbon nanotube network from the matrix. The resulting carbon nanotube material includes a shell having a network of carbon nanotubes and either (i) a single discrete void space defined by the network of carbon nanotubes or (ii) the encapsulated core surrounded by the network of carbon nanotubes.
US10214420B2 Method, system, and device for delivery of process gas
A method and chemical delivery system and device are provided. One method includes contacting a non-aqueous hydrazine solution with a carrier gas and/or vacuum and delivering a gas stream comprising hydrazine to a critical process or application. One chemical delivery system and device includes a non-aqueous hydrazine solution having a vapor phase that is in contact with a carrier gas and/or vacuum. One device includes a chamber for containing a liquid comprising at least one volatile process chemical, such as a non-aqueous hydrazine solution, a hydrogen peroxide solution, or another suitable process chemical, and a head space from which the volatile can be drawn using a carrier gas and/or vacuum. Another method useful in the present invention involves drawing a process chemical from a device as a disclosed herein using a carrier or vacuum and delivering the process chemical to a critical process or application.
US10214409B2 Refrigerator
A refrigerator includes a main body defining a storage space therein, a door that opens and closes the storage space, and a hot water module including an instantaneous heater for heating water. The hot water module measures a flow rate of water along with a temperature of water introduced to the instantaneous heater to ensure the proper amount and temperature of water is dispensed.
US10214407B2 Systems for cooling hot-filled containers
Systems and methods using container holders configured to provide a stable support for containers held therein in order to efficiently cool the containers after a hot-fill or elevated temperature operation. The container holders can allow a fluid to pass from an inner volume of the container holder to outside the container holder through side apertures and/or an open bottom end of the container holder. Groups of containers and container holders also may be cooled. Groups of containers in container holders can be processed through the cooling operation at a speed different from a speed for holderless containers.
US10214404B2 Test tube capping and de-capping apparatus
An apparatus (100) for automated capping and de-capping of test tubes (112) having an ejector pin (230) system for individualized cap (113) ejection.
US10214402B2 Personnel lift vehicle
The present disclosure relates generally to personnel lift vehicles that include a carriage, a telescoping lift and a load carrying frame. The telescoping lift is connected to a rear portion of the carriage and the load carrying frame is connected to and extends forward from the telescoping lift. The load carrying frame includes a bottom portion that provides an operator platform that is disposed at a central portion of the carriage between a front portion and the rear portion of the carriage. The configuration of the disclosed personnel lift vehicle provides an integral solution for counterweight requirements for the carriage while reducing the overall driving space required for the vehicle.
US10214401B2 Modular powered mover attachment
Apparatus for moving different movable loads. The apparatus includes channels that can be engaged by a fork lift, pallet jack, or other powered mover. The apparatus also includes a mounting plate disposed between the channels. The mounting plate includes a receiver channel. The apparatus includes a plurality of load support tools that can selectively engage the receiver channel. The load support tools include different respective end effectors. A load can be engaged with the end effector of a selected load support tool such that the apparatus can move the load.
US10214396B2 Device for determining the replacement state or wear of a rope during use in lifting gear
The present invention generally relates to lifting gears such as cranes which use ropes such as high-strength fiber ropes. The invention in particular relates to a device for determining the discard state of such rope in use on such lifting gears, comprising a detection device for detecting at least one rope utilization parameter influencing the discard state and an evaluation unit for evaluating the rope utilization parameter and for providing a discard signal in dependence on the rope utilization parameter evaluation. According to the invention the detection unit has at least one detecting means for detecting environmental influences on the rope, which can be evaluated by evaluation devices to recognize the discard state.
US10214395B2 Gantry assembly and a system for replacing single or double railway bridges
A gantry assembly includes a main beam extending between a first and a second end. A plurality of legs including a pair of first legs and a pair of second legs attached to the main beam. A pair of first trolleys is slidably attached to the main beam. A first girder is attached to each one of the first trolleys and extends outwardly from the first trolleys for movement with the first trolleys. The first girder includes a pair of posts having a first and a second post disposed spaced from one another. The first post is attached to the first girder and extends downwardly from the first girder. The second post is slidably attached to the first girder and is movable along the first girder toward and away from the main beam allowing the gantry assembly to have different widths to accommodate for a single or double railway bridge.
US10214393B2 Lifting apparatus and method of use
A lifting apparatus may include a bolt assembly and a nut assembly. The bolt assembly may include a support plate, a bolt and a lifting eye attached to the support plate. The nut assembly may include a support plate, a nut and a handle attached to at least one of the support plate and the nut. A tether may also be included to connect the bolt assembly to the nut assembly.
US10214391B2 System and method for monitoring handrail entrance of passenger conveyor
The present invention provides a handrail entry monitoring system of a passenger conveyor and a monitoring method thereof, and belongs to the field of passenger conveyor technologies. In the handrail entry monitoring system and the monitoring method of the present invention, at least part of a handrail entry region of the passenger conveyor is sensed by using an imaging sensor and/or a depth sensing sensor, to acquire a data frame, and the data frame is analyzed to monitor whether a handrail entry of the operating passenger conveyor is in a normal state or an abnormal state. The monitoring system of the present invention and the monitoring method thereof can timely and effectively detect a danger that a foreign matter is about to be entrapped into the handrail entry, helping prevent foreign matters from being entrapped into the handrail entry, thereby improving safety of the passenger conveyor.
US10214384B2 Method for operating an elevator safety system with temporary participants
A method for operating a safety system including a control unit, a bus, a plurality of bus nodes connected to the control unit via the bus, and a plurality of participants connected to the control unit via the bus nodes, wherein at least one participant is designed as a temporary participant. The method includes the step of enabling the safety system for operation by the control unit when either a first temporary participant or a second temporary participant is connected to the bus. An elevator system can be provided with a safety system for carrying out the method.
US10214382B2 Disk damping device
An elevator brake disk assembly is provided. The elevator brake disk assembly includes a brake disk which is keyed to and rotatable with a shaft of an elevator machine, a machine frame and dampers. The dampers are respectively anchored to the machine frame and biased to symmetrically hold the brake disk during rotations thereof.
US10214378B2 Cable coiling machine
The cable coiling device automatically coils heavy-duty electrical cable into a coiled bundle having a predetermined coil diameter. This device matches the over/under coiling method used to manually coil cables that eliminate unnecessary twists and knots in cables. The cable coiling device has a first roller and a second roller that is angularly offset from the first roller. The angular offset adds a twist to the cable as it passes between the rollers. The device maintains the first and second rollers at a predetermined distance away from each other so that the cable does not slip out of the opening between the rollers. When the coil exits the rollers, the resulting cable is coil bundled and has a specific predetermined coil bundle diameter. Guide wheels positioned at specific locations guide the cable through the device, which prevents cable looping before and after the cable passes through the rollers.
US10214372B2 Sheet feeder device and image forming apparatus
A sheet feeder device includes: a pickup roller that separates paper sheets placed on a manual feed tray from one another, and transfers a paper sheet; a pair of sheet feed rollers that include an upper feed roller and a lower feed roller, form a sheet nip portion when the upper feed roller and the lower feed roller are pressed against each other, and transfer the paper sheet transferred from the pickup roller; a top edge vibrator that vibrates a top edge of the paper sheet, the top edge vibrator being located on an upstream side of the pair of sheet feed rollers; and a hardware processor that controls sheet feeding of the paper sheets placed on the manual feed tray, wherein, when a predetermined condition is satisfied in the sheet feeding, the hardware processor controls the top edge vibrator, to vibrate the top edge of the paper sheet.
US10214370B2 Sheet feeding apparatus and image forming apparatus
A sheet feed portion feeds a sheet by performing a pickup operation in a cycle in which a pickup rotary member is switched from a released state to a contact state and then switched to the released state. A detection unit detects the sheet at a position downstream of the sheet feed portion in the sheet feeding direction. A control unit is capable of executing a first feed mode in which a first feed process of carrying out a pickup operation is executed, or a second feed mode in which the first feed process is executed and then a second feed process of carrying out an additional pickup operation is executed. The mode to be executed is determined based on a time when the sheet is detected by the detection unit and a length of the sheet.
US10214368B2 System using magnetic coupling to move a carriage
A system for moving a receptacle. The system includes: a coupling wall; an internal carriage provided substantially adjacent the coupling wall, the internal carriage being movable along the coupling wall along a predetermined path; an external carriage provided substantially adjacent the coupling wall and substantially in register with the internal carriage with the coupling wall extending between the internal and external carriages, the external carriage being movable along the coupling wall, the external carriage including a receptacle attachment for securing the receptacle thereto; and a carriage actuator operatively coupled to the internal carriage for moving the internal carriage along the predetermined path. The internal and external carriages are magnetically coupled to each other across the coupling wall so that when the internal carriage is moved along the predetermined path, the external carriage follows the internal carriage and remains substantially in register therewith.
US10214367B2 Rotating stacker
Some manufacturing processes include forming stacks of manufactured objects for handling and/or processing. While some such manufactured objects are consistent in thickness, other are more irregular. Some manufactured objects are generally flat, but are also generally thicker along one edge. When objects having these characteristics are stacked, the cumulative effect of such inconsistent thickness results in an unbalanced stack. The disclosed apparatus and method utilize a novel rotating stacker that rotates the stack of manufactured objects as each new object is added to the stack, thereby distributing the thickness inconsistency of individual objects throughout the stack, producing a more uniform stack without manual intervention.
US10214366B2 Drop batch builder technology
A drop batch builder is provided for organizing a plurality of glass sheets into a desired batch arrangement on a conveyor. The drop batch builder includes an upper conveyor line and a lower conveyor line. The upper conveyor has a drop region configured to drop a first glass sheet from the upper conveyor line downwardly onto the lower conveyor line, whereupon the lower conveyor line is configured to convey the first glass sheet along the lower path of substrate travel to the overpass region where the first glass sheet is positioned under the upper conveyor line. Methods of using a drop batch builder are also provided.
US10214361B2 Rake device on friction-driven sweep conveyor
We disclose an apparatus for maintaining a flow of grain moving toward a rotating sweep conveyor. A rake extends longitudinally along the sweep. The rake is disposed along the leading sidewall of the sweep such that the rake is in the path of movement of the sweep as the sweep rotates within the bin. The rake has a plurality of projections that protrude from a shaft. A reciprocating drive assembly is connected to the driven roller and to the shaft. The reciprocating drive assembly causes the shaft to move forward and backward along the longitudinal axis of the sweep. The reciprocating shaft movement causes the projections to engage grain piles in the path of the sweep, causing the pile to collapse into a flowable particulate to be received by the sweep.
US10214357B2 Lift roller for power drive unit
A lift roller may include a hub having a first surface, a second surface opposite the first surface, and a radially outward surface. The hub may define a channel extending through the hub from the first surface to the second surface. The lift roller may also include a rim portion rotatably disposed about the radially outward surface of the hub and a boss disposed on one of the first surface and the second surface.
US10214356B2 Transporting element for accommodating and transporting spherical, cylindrical or egg-shaped articles, and a cooking appliance, pasteurizer or cooling unit
A transporting element for accommodating and for transporting spherical, cylindrical or egg-shaped articles, in particular foodstuffs, in particular eggs, along a conveying route, has a plurality of mounts arranged one beside the other along the longitudinal extent. The transporting element is designed in the form of a channel-like body with an accommodating space curved in the form of part of a circle, as seen in cross section, and encloses an angle of at least 180°. The mounts are designed in the form of slot-form apertures in that region of the channel-like body that is curved in the form of part of a circle. The apertures extending parallel to one another, and transversely to the longitudinal extent of the channel-like body, as far as longitudinal crosspieces on either side, these forming a respective longitudinal periphery.
US10214348B2 Air-ventilated trash container system
An air-ventilated trash container suitable for supporting a collapsible trash bag having an open-top hollow container body that includes an integrated sidewall joined to a closed bottom is provided. The integrated sidewall includes an upright inner sidewall configured with a plurality of upper air release orifices and a plurality of laterally spaced apart, generally vertical ribs disposed extending outwardly from the inner sidewall. The ribs define between themselves a plurality of narrow channels that extend longitudinally to provide a passage during bag installation for the escape of air trapped between the inner sidewall, during bag filling to allow the bag to fully expand, and during bag removal to prevent the formation of a vacuum that would tend to cause the retention of the bag inside the container.
US10214345B1 Entryway protective collar
Embodiments of the invention are directed to a protective collar that covers the edges of a manhole or other personnel entryway. One device comprises at least two pieces and a hinge that connects the two pieces, which allows the device to be folded for storage. Another device includes a skirt portion that extends further into the manhole. A further device includes at least one light to provide light into the manhole. A still further device includes a surface port that provides a connecting point for a line, and a subsurface port that provides a connecting point for another line. A still further device includes another portion to cover any equipment that has been inserted into the manhole. A still further device includes at least one rung to assist in personnel in entering and exiting the manhole.
US10214342B2 Dispenser box for fragile items, including tubes for cigarettes
A dispenser carton for cigarette tubes having a cutout shaped to outline a flap that is folded on one panel of the carton making it possible, after the cutout has been broken, to open the carton at the flap to access the tubes, while at the same time making it possible to re-close the carton by replacing the flap in its initial closed position.
US10214339B2 Apparatus, arrangement and method for providing skin care ingredients
According to an exemplary embodiment of the present disclosure, a cosmetic arrangement can be provided, which can include a first structure that can enclose a cosmetic active ingredient(s), a second structure that can enclose a solvent solution, a third structure(s) that can separate the solvent solution from the cosmetic active ingredient(s), a medium that can be configured to absorb a mixture of the cosmetic active ingredient(s) and solvent solution, and an indicator structure that can be configured to indicate whether the cosmetic active ingredient(s) and the solvent solution have come in contact with one another. Upon an application of a particular amount of pressure on a portion(s) of the arrangement, the cosmetic active ingredient(s) and the solvent solution can be caused to come into direct contact with one another.
US10214337B2 Precision scored exterior pocket for flexible package
A flexible walled package formed from a multiple layer laminate and having an external recloseable pocket for holding a scoop or other item is provided. The pocket has a back panel formed from part of an inner layer and a front panel formed from part of a scored outer layer. Outside the perimeter of the pocket the inner layer and the outer layer are adhered together with permanent adhesive. Inside the pocket perimeter the inner layer and the outer layer may be adhered together with pressure sensitive adhesive to close the pocket.
US10214335B2 Tamper evidence feature
A spiral part used as a tamper evident feature an a peal reclose label. The spiral is formed on a pressure sensitive adhesive label, and the spiral is unraveled in order to open the package. Once unraveled, it is difficult to reclose the package with the spiral in its original place. In one embodiment, there is a special color to the label, so that once the package is opened, it can be seen.
US10214332B2 Beverage container cap holder
An elastomeric cap is fitted to the removable closure of a beverage container or bottle. A tether is fastened to the cap with a small loop that readily swivels. At the other end of the tether is a larger loop which can fit around the neck of the container or bottle. The tether restrains the closure when it is removed from the container thereby minimizing the likelihood of loss of the closure. The cap can be separated from the tether and replaced by a cap of different color or with decorative graphics.
US10214326B1 Tamper evident ring/bottle system
A one piece closure has a distal section, a proximal section, and an intermediate section. The intermediate section has a cylindrical center with a first annular fold extending radially inwardly and a second annular fold extending radially inwardly. The first and second folds are parallel forming an annular channel there between extending for less than 360 degrees creating a gap. The cylindrical center is formed with a hole. A C-shaped snap ring is positioned within the annular channel. The snap ring has spaced free ends. The snap ring has a projection sized to extend into the hole in the cylindrical center. The projection of the snap ring is of a first color. The remainder of the snap ring is of a second color.
US10214325B2 In or relating to tamper-evident closures
A tamper-evident closure (10) for a container is provided. The closure (10) comprises a base (20) attachable to a container neck (50). The base (20) comprises a sidewall (21) having a tamper-evident drop band (40). The band includes an abutment (43) for engaging the container neck to cause the band to break away from the sidewall if an attempt is made to remove the closure from the neck once fitted. The band (40) further comprises an extension (45) against which the sidewall pushes if the closure is reapplied to push the band (40) away from the base (20).
US10214323B2 Cap assembly having inside seal
A seal and method of forming a seal for a resealable container includes a removable cap that is selectively received over a pour opening formed in a can body. A seal is adhered to the end wall of the cap and includes a continuous, first axial region extending outwardly from the inner surface of the cap. The seal first region is dimensioned for engagement with the opening in the container and sealing the container along an inner diameter thereof. Reduced on-torque/off-torque are required since the seal is formed on the inner diameter, and a down force is substantially reduced to assemble the cap to the container.
US10214322B2 Child resistant plastic bag assembly
A child resistant, zippered plastic bag assembly having a first side panel and a second side panel each having respective upper portions forming a mouth. The bag assembly includes a zippered closure coupled to the respective upper portions of the first and second side panels for interlocking the mouth between an opened condition and a closed condition. A slider having a base operably mounted to, and cooperating, with the zipper closure for movement between a first position, orienting the mouth in the closed condition, and a second position, orienting the mouth in the opened condition. The slider includes a first wing extending outwardly from the base, adjacent the upper portion of the first side panel, and a second wing also extending outwardly from the base, adjacent the upper portion of the second side panel. A lock is operable between the first wing and second wing, and configured to cooperate with the first side panel and the second side panel in a locked state to lock the slider in the first position.
US10214321B2 Container for a consumable good, coated with a resveratrol containing layer
The present invention relates to a container for a consumable good, wherein the container has an inner coating layer including resveratrol, and process for preparing the container.
US10214316B2 Method for manufacturing biodegradable packaging material, biodegradable packaging material and packages and containers made thereof
A biodegradable packaging material, a method of manufacturing the same, as well as products made of the material wherein a multilayer coating coextruded onto a fibrous substrate the multilayer coating comprising innermost and outermost layers of a blend comprising 20-95 wt-% of a higher melt index polylactide and 5-80 wt-% of another biodegradable polymer such as polybutylene succinate, and a middle layer containing a lower melt index polylactide alone. The goal is to increase machine speed in coextrusion while maintaining good adhesiveness to the substrate and good heat-sealability of the coating. The products include disposable drinking cups and board trays, as well as sealed carton packages for solids and liquids.
US10214312B2 Lightweight plastic container and preform
A plastic container is provided that includes a hollow body portion including a lower supporting base portion; a sidewall portion extending upwardly from the base portion; and a neck portion extending upwardly from the sidewall portion. The neck portion includes a support flange having an upper and lower surface, a tamper-evident formation, and a dispensing opening at the top of the neck portion. In embodiments, a closure may be provided to form an assembly. In embodiments, the container is comprised of polyethylene terephthalate (PET), a volume of the container is at least 500 ml, and/or the weight of the neck portion is 2.3 grams or less. A preform and method for making a container are also disclosed.
US10214307B2 Supporting structure for packaging machines
A module structure for a packaging machine comprising vertical members and horizontal beams, including horizontal beams configured as open beams, having an open polygonal cross section and comprising at least a first end face, a second end face, one or more intermediate faces between said first and second end faces, said end faces being distanced in such a way to leave a longitudinal aperture of the beam; said open beams may include reinforcing flanges and accommodate power/signal cables.
US10214300B2 System and method for displaying runway overrun information
A system and method are provided that improve upon existing aircraft display systems by generating and updating an overrun image that may be overlaid on a variety of panoramic and landscape images on a display device. The overrun image displays stopping locations for all relevant available stopping devices, as determined from the far end of the selected runway. In addition, the aircraft display system determines an advisory zone on the selected runway and presents limited symbols and images in and near the advisory zone that indicate distances and relevant information.
US10214296B2 Architecture of a multi-engine helicopter propulsion system and corresponding helicopter
The invention relates to an architecture of a propulsion system of a multi-engine helicopter, comprising turboshaft engines (1, 2) that are connected to a power transmission gearbox (3), and comprising a low DC voltage onboard network (7) for supplying helicopter equipment during flight, characterized in that it comprises: a hybrid turboshaft engine (1) that is capable of operating in at least one standby mode during a stable flight of the helicopter; an electrotechnical pack (20) for quickly restarting said hybrid turboshaft engine in order to bring said engine out of said standby mode and to reach a mode in which it provides mechanical power, said restart pack (20) being connected to said onboard network (7); and at least two sources (4, 16, 18) of electrical power for said onboard network (7).
US10214291B2 Energy absorbing assembly for a seat
The energy absorbing assembly may include a seat frame having a base, a seat pan coupled to the seat frame, and a deformable member disposed substantially between the seat pan and the base of the seat frame. In various embodiments, the seat pan is configured to support a passenger in a seated position and the deformable member is configured to undergo plastic deformation in response to a first compressive load on the deformable member.
US10214284B2 Pitch bearing
A pitch bearing for connecting first and second articles is provided. The first article includes a first curved outer surface and the second article includes a second curved outer surface opposite the first curved outer surface. The pitch bearing includes an axisymmetric structure interposed between the first and second curved outer surfaces. The axisymmetric structure includes compliant layers and stabilizing layers interleaved between the compliant layers. The compliant layers and the stabilizing layers proximate to the first article haves a curvature matching that of the first curved outer surface. The compliant layers and the stabilizing layers proximate to the second article have a curvature matching that of the second curved outer surface. A shear stiffness of each of the stabilizing layers is greater than a shear stiffness of each of the compliant layers.
US10214280B2 Hydraulic cylinder for aircraft landing gear
A hydraulic cylinder includes: a cylinder tube; a piston; a piston rod; a pair of end covers; and a snubbing mechanism configured to reduce the moving speed of the piston after the piston reaches the vicinity of the end of its stroke. The snubbing mechanism includes: a supply/discharge port formed in an associated one of the end covers; a valve configured to open and close the supply/discharge port; a connector configured to connect the valve and the piston together; and at least one recess extending from the edge of the supply/discharge port. When the piston approaches the end of its stroke, the valve closes the supply/discharge port to form a throttle oil passage, and hydraulic oil is discharged through the throttle oil passage to reduce the moving speed of the piston.
US10214279B2 Operating aerial vehicles with intentionally imbalanced propellers
Aerial vehicles may be operated with discrete sets of propellers, which may be selected for a specific purpose or on a specific basis. The discrete sets of propellers may be operated separately or in tandem with one another, and at varying power levels. For example, a set of propellers may be selected to optimize the thrust, lift, maneuverability or efficiency of an aerial vehicle based on a position or other operational characteristic of the aerial vehicle, or an environmental condition encountered by the aerial vehicle. At least one of the propellers may be statically or dynamically imbalanced, such that the propeller emits a predetermined sound during operation. A balanced propeller may be specifically modified to cause the aerial vehicle to emit the predetermined sound by changing one or more parameters of the balanced propeller and causing the balanced propeller to be statically or dynamically imbalanced.
US10214278B2 Aircraft comprising a foldable aerodynamic structure and an articulation mechanism for a foldable aerodynamic structure
An aircraft, for example a passenger aircraft, comprises a foldable wing having an inner region and an outer region. The outer region is moveable relative to the inner region between a flight configuration, an intermediate configuration, and a ground configuration. In the flight configuration the inner and outer regions are locked together via a multiplicity of connectors for transferring loads. In the intermediate configuration the outer region is displaced, for example forwardly, such that the connection is disengaged to unlock the outer region from the inner region. In the intermediate configuration the outer region is also connected to the inner region via a hinge. In the ground configuration, the outer region is rotated about the hinge, such that the span of the wing is reduced.
US10214277B1 System and method for improving fuel storage within a wing of an aircraft
A system and method for improving fuel storage within the wing of an aircraft. In one exemplary embodiment, the system and method eliminate the traditional spars and ribs, and any spanwise and cordwise connecting vertical webs, within a wing. Instead, the system comprises a plurality of modified flared spars, each having a length defined by an angled hat section, to form a wing structure. The modified flared spars may also comprise one or more lengths defined by a specialized section configured to accommodate a portion of a box section, or any other internal component of the wing. The system and method may also involve a contiguous fuel bladder of any size/type. The fuel bladder for the wing may comprise a fabric coated or impregnated with an elastomeric material that may include a polyurethane dispersion layer combined with a sealant.
US10214269B2 Folding propeller
A folding propeller for a boat, e.g., for a sailboat or a multihull yacht, and a method for installing and/or adjusting such a folding propeller, where said folding propeller has a hub for directly or indirectly fastening at a driveshaft connected to a motor, where said folding propeller further has at least two individual blades, where each of said blades has a root arranged to pivot around a pivot pin at said hub to be either in a first, operative position, where the blades are pointing mainly in a radial direction, and in a second, inoperative position, where the blades are pointing mainly in an axial direction, where said hub has one or more cut outs for said blades roots and further has a first set of holes for installing said pivot pins and a second set of holes for installing a locking device for engagement with said pivot pins.
US10214257B1 Device for placing and replacing vehicle glass
The device for placing and replacing a window of a motor vehicle, such as a windshield, includes a support beam formed by a post. The lower end is fastened on a base, while the upper end is secured to a beam rotating around the axis of the post. A set of suction cups is secured to a bar, and there are means for suspending the bar from the beam and means for adjusting the height of the bar suspended from the beam. The device can include a means for temporarily securing the bar to the post. The suction cups are mounted rotating on the bar around the axis of the bar and around an axis perpendicular to the axis of the bar.
US10214255B1 Undercarriage panel for increasing fuel efficiency by reducing drag of a vehicle
A drag-reducing undercarriage panel for a vehicle includes a planar main body sloping into an arcuate front section extending rearward over at least a portion of the planer main body creating a curved front edge; a pair of spaced outer members extending outward from opposite sides of a front portion of the planar main body; and multiple attachment sections for attaching the undercarriage panel to a vehicle. The undercarriage panel reduces or eliminates turbulent air beneath a moving vehicle caused by the vehicle's rotating front tires and uneven and rough undercarriage.
US10214252B2 Drag reducing aerodynamic vehicle components and methods of making the same
A process of making a drag-reducing aerodynamic vehicle system includes injection molding a body configured for attachment to a roof of a vehicle with a sliding core, wherein the body comprises an air inlet extending through a surface of the body, wherein the air inlet includes an air guide boss extending from an interior surface of the body, wherein the air guide boss adjusts an air stagnation point away from the windshield to reduce air pressure and drag on the vehicle; and ejecting the drag-reducing aerodynamic vehicle system from the injection mold using the sliding core.
US10214248B2 Tripartite support mechanism for frame-mounted vehicle components
A vehicle is described herein that includes a unibody vehicle frame, a vehicle body panel, and one or more monolithic tripartite support mechanisms, which mechanisms provide structural support for at least three frame-mounted vehicle components. Each support mechanism includes a windshield support arm, a side view mirror support arm, and a body panel fixing plate. The side view mirror support arm extends from the windshield support, and the body panel fixing plate extends from the windshield support arm, the side-view mirror support arm, or both. Additionally, the windshield support arm holds a windshield to the vehicle, the side view mirror support arm holds a side view mirror to the vehicle, and the fixing plate secures the body panel to the frame.
US10214246B2 Bonnet mounting apparatus of agricultural work vehicle
A bonnet mounting apparatus of an agricultural work vehicle enables a bonnet that covers an engine compartment of an agricultural work vehicle to be opened upward. The bonnet mounting apparatus includes: a fastener on which a coupling protrusion is provided, and which is attached to the inside of one end portion of a bonnet; and a hinge on which a coupling recess, into which the coupling protrusion is inserted, is provided, and which is hingedly coupled to the upper end of a bonnet support at a vehicle body side so as to be rotatable upward and downward. According to the present invention, the bonnet is easily connected to the vehicle body by inserting the coupling protrusion of the bonnet into the coupling recess of the hinge at the vehicle body side.
US10214245B2 Partition panel for vehicles and method of manufacturing the same
Disclosed are a partition panel for vehicles and a method of manufacturing the same. The partition panel for vehicles includes a panel part formed of a composite material to divide a trunk and the inside of a vehicle from each other and a reinforcement part formed of a composite material, inclined upwards from the center of the lower portion of the panel part to both ends of the panel part, and connected integrally to the panel part.
US10214238B2 Voltage compensating anti-catch algorithm for active front steering system
A vehicle implements a steering anti-catch (SAC) algorithm that reduces a superimposition angle added to the steering wheel angle in order to reduce occurrence of steering catch. The superimposition angle may be determined according to an AFS system. The reduction of the superimposition angle according to the SAC algorithm is amplified when the driver is steering away from a center position, the vehicle speed is below a threshold, and a voltage for powering the power steering system is below a threshold. The amount by which the superimposition angle is reduced may be limited to a maximum reduction and may be subject to a limit in its rate of change as well.
US10214237B2 Device for determining steering wheel rotation information and method for determining steering wheel rotation information
A device for determining steering wheel rotation information, which comprises a linear motion transforming element connected to a steering column of a steering wheel for transforming rotation of the steering wheel into a linear movement, and a processing element electrically connected to the linear motion transforming element for determining steering wheel rotation information based on the linear movement transformed by the motion transforming element.
US10214236B2 Selectively deployable control device
A vehicle (100) comprises a docking port and a selectively demountable switch (10) having a body and a rotary knob (40) on the body, and an interface between the switch and the docking port to enable commands entered by operation of the rotary knob to be communicated to the vehicle (100). The vehicle (100) incorporates a tow-assist system to facilitate reversing of a trailer, the vehicle (100) being of the type having a positive power-assisted steering mechanism (350) for its steerable wheels (250). The system comprises computing means (310) and the demountable switch (10). The computing means (350) is arranged to interpret rotational movement of the knob (40) on the body as desired steering movements of the trailer when the vehicle (100) is being reversed and to effect steering commands for the positive power assisted steering mechanism (350) to achieve said desired steering movements of the trailer.
US10214224B2 Rail road hopper car
A hopper car discharge section may be wide at the top and narrow at the bottom. Outflow is controlled by movable closure members. The hopper car has a plurality of hoppers of which two hoppers share a common ridge assembly. The ridge assembly forms a common mating and fit up location for the upper margins of the slope sheets of two lengthwise adjacent hoppers. The ridge assembly includes an horizontal center section and two end plates that angle upwardly outboard toward the top chords of the side walls. The ridge assembly stands proud of the upper margin of the respective adjacent slope sheets. A gusset is mounted between the adjacent slope sheets below the ridge plate such that the slope sheets and gusset form a reinforcement tube running across the car, the end plates forming the stems of a vertical T-section attached to the side wall and overlapping the top chord.
US10214214B2 Vehicle control device and control method therefor
A vehicle control device includes control means for executing coasting control to disengage a friction engaging element and set a rotation speed of a rotary shaft of a drive source at zero when a predetermined condition is established, the predetermined condition including at least a condition according to which an accelerator pedal is not depressed. The control means starts the coasting control after predicting that an actual speed ratio of a continuously variable transmission will be modifiable to a target speed ratio of the coasting control during the coasting control, even in a case where the accelerator pedal is not depressed but the actual speed ratio has not yet reached the target speed ratio.
US10214210B2 Vehicle gear transition during braking event
An apparatus for a host vehicle comprises an input for receiving a signal indicative of a target object, an output for transmitting at least one of an acceleration message, an engine control message and a transmission control message and a processor having control logic. The control logic transmits the acceleration message to request a negative acceleration of a host vehicle in response to a signal indicating a detected target object in order to maintain a predetermined following time behind the detected target object and transmits a transmission control message to request the transmission to shift to neutral in response to the negative acceleration having a value less than a predetermined negative acceleration value.
US10214209B2 Driver assistance system in a motor vehicle
A driver assistance system in a motor vehicle includes a detection system for detecting upcoming events which permit an increase in current speed as a result of the lifting of a restriction on a currently valid speed, a functional unit for determining an acceleration strategy for increasing the speed, and an information system for issuing request information to the driver to allow automatic implementation of the acceleration strategy. The functional unit initiates the automatic implementation of the acceleration strategy upon confirmation by the driver of the request information. The request information can be issued to the driver already at a defined point in time before the upcoming event that lifts the restriction on the current speed. If the driver confirms the request information before the upcoming event that lifts the restriction on the current speed has been reached, the functional unit initiates an acceleration strategy that is composed of two-stages.
US10214205B2 Hybrid vehicle
A hybrid vehicle includes an engine; a generator that generates a counter-electromotive force; a motor; a first inverter for the generator; a second inverter for the motor; a step-up converter that steps up an electric power of a first voltage system electric power line and supplies the electric power to a second voltage system electric power line; and a smoothing capacitor of the second voltage system electric power line. In a case where the hybrid vehicle travels by driving the engine in a state in which the stepping up by the step-up converter and an operation of the first inverter are stopped when an abnormality occurs in a voltage sensor, when an electronic control unit determines that there is an indication that the voltage of the capacitor will rise, the first inverter is controlled to cause three phases of the first inverter to be in an ON state.
US10214201B1 Liquified light hydrocarbon fuel system for a hybrid electric vehicle
A liquefied light hydrocarbon (LLH) fuel system for a hybrid electric vehicle is disclosed. The fuel system uses a stable supply of vaporized (LLH) fuel to meet the highly variable power demand from the vehicle's power train by 1) adjusting the evaporation rate inside an insulated fuel tank through a heat delivery system, 2) managing the amount of compressed fuel vapor stored inside a buffer tank and 3) using an electric energy storage means to provide for rapid fluctuations in demand. In an embodiment the apparatus comprises an insulated fuel tank, a buffer tank, a heat delivery system, an energy conversion means to convert the vaporized fuel into electricity and an electric energy storage means that can provide for rapid variations of power demand from the vehicle. Methods of using the fuel system under various operational scenarios are also disclosed.
US10214200B2 Hybrid vehicle
In a hybrid vehicle including an engine; a first motor configured to generate reverse voltage by rotation; a planetary gear mechanism configured to have three rotational elements connected with a drive shaft coupled with an axle, the engine and the first motor; a second motor configured to input and output power from and to the driveshaft; first and second inverters configured to drive the first and second motors respectively; and an electric storage device, a first control controlling a rotational speed of the engine such that a first electric current to flow through the electric storage device is maximized in a state of gate interruption of the first and second inverters is executed at the time of an evacuation travelling being performed when an ON operation of an accelerator is performed during an inverter failure in which the first and second inverters cannot be normally actuated.
US10214197B2 Hybrid electric vehicle, method and apparatus for controlling operation mode of the same
A method and an apparatus for controlling an operation mode of a hybrid electric vehicle and a hybrid electric vehicle are provided in the present disclosure. The method includes: detecting a current state of charge of a power battery and an expected torque at wheels in the hybrid electric vehicle; maintaining a current operation mode of the hybrid electric vehicle, if it is detected that the current state of charge enters a state hysteresis area or the expected torque at wheels enters a torque hysteresis area; obtaining a duration of the current operation mode and determining a next operation mode of the hybrid electric vehicle according to the duration, the current state of charge and the expected torque at wheels, if it is detected that the current state of charge exits the state hysteresis area and the expected torque at wheels exits the torque hysteresis area. With the method, the problems of frequently switching from one operation mode to another operation mode may be avoided, the comprehensive performance of the hybrid electric vehicle and the fuel economy may be improved, and the user experience may be enhanced.
US10214196B2 Hybrid vehicle
The electronic control unit sets a target value of a charging amount of the electrical storage device and increases the charging amount to the target value during traveling on the freeway. The electronic control unit computes a first travel cost being cost per unit travel distance of fuel used when the EV travel is made by using the electric power charged in the electrical storage device at a time when the HV travel is made on the freeway, and the second travel cost being cost per unit travel distance of the electric power used when the EV travel is made by using the electric power charged in the electrical storage device by the charging mechanism at the destination. The electronic control unit sets the target value on the basis of a comparison result between the first travel cost and the second travel cost.
US10214193B2 Hydraulic braking device
This hydraulic braking device is provided with: a tubular cylinder; an assisting piston, which is housed in the cylinder so as to be able to move reciprocally, faces a reservoir formed inside the cylinder, and assists a master piston, in a master cylinder, that generates hydraulic pressure for generating a braking force by reciprocally moving from one side to the other as a result of a fluid flowing into the reservoir from a supply source; and a seal member, which is elastically deformable and which seals the reservoir. When the assisting piston is at a location on one side, the reservoir is compartmentalized into a first chamber that communicates with the supply source, and a second chamber that communicates with the first chamber through a restricting flow passage, and the seal member seals the second chamber.
US10214192B2 Solenoid valve for a vehicle braking system
In one embodiment, a solenoid valve for a vehicle braking system includes a magnet assembly having a winding support, a coil winding, a housing, and a cover disc. The solenoid value further includes a valve cartridge having a capsule, a valve insert, a valve seat, and an armature. The valve insert can be connected to the capsule, the armature can be guided within the capsule in an axially movable manner and has a closing element. The closing element and the valve seat can form a valve that can control a fluid flow through the valve cartridge. The coil winding can be wound on the winding support to form an electrical coil, which can be controlled using control signals applied to electrical connectors. The electric coil generates a magnetic force that can move the armature against a force of a return spring.
US10214188B2 Control apparatus for hydraulic components of a braking system of a vehicle, and method for executing an antilock braking function at at least one wheel brake cylinder of a vehicle
A control apparatus for hydraulic components of a braking system of a vehicle, having a control application device that is designed to establish by application of control to the hydraulic components, in consideration of the braking request, at least one brake pressure in at least one wheel brake cylinder in such a way that the braking request is satisfiable; and to execute an antilock braking function at the at least one wheel brake cylinder, the control application device additionally being designed to ascertain whether at least one furnished actual value with regard to a displacement travel (s) of a brake actuation element of the vehicle out of its initial position, and/or with regard to a simulator volume shifted out of a brake master cylinder of the vehicle into a linked simulator, lies within at least one predefined extreme value range.
US10214187B1 Trailer jacking system
A trailer jacking system includes a trailer that has a pair of axles, a first lateral side and a second lateral side. A pair of bars is provided and each of the bars is coupled between each of the axles. A jack is selectively positioned beneath the bars for jacking the trailer. Each of the bars is oriented collinear with an associated one of the first and second lateral sides. In this way each of the bars facilitates the trailer to be leveled between the first and second lateral sides when the trailer is jacked. A plurality of u-bolts is provided and each of the u-bolts bolts is coupled between the bars and an associated one of the axles to retain the bars on the axles.
US10214185B2 Quick connecting device for fin ray wiper
The invention relates to a windshield wiper device (100) for a vehicle, comprising a wiper blade (2) having an elongated upper part (10) and an elongated lower part (12), which are configured to be flexible, at least in part. Also provided are multiple connecting elements (18) for connecting the upper part (10) and the lower part (12), the connecting elements being mutually spaced along a longitudinal extent (8) of the wiper blade (2) and being attached to the upper part (10) and/or the lower part (12) by a rotary joint, and the connecting elements (18) being designed to allow a movement of the upper part (10) and the lower part relative to each another with a movement component along a longitudinal extent (8) of the wiper blade (2). Said windshield wiper device further comprises a quick-connecting device (32) which is designed such that the windshield wiper device can be detachably connected to a drive shaft (35) of a drive unit of the vehicle. At least one engagement part (36) and an elastic clamping jaw (38) cooperate in order to switch when applying an external force between a clamping position (K) and a release position (F).
US10214184B2 Fastening arrangement for fin ray wiper
The invention relates to a windscreen wiper device for a vehicle, comprising a wiper blade (2) having an elongate upper part (10) and an elongate lower part (12) which are at least partially flexible. Also provided are multiple connecting elements (18) for connecting the upper part (10) and the lower part (12), the connecting elements being mutually spaced along a longitudinal extent (8) of the wiper blade (2) and being attached to the upper part (10) and/or the lower part (12) by a rotary joint, and the connecting elements (18) being designed to allow a movement of the upper part (10) and the lower part relative to each another with a movement component along a longitudinal extent (8) of the wiper blade (2). The wiper blade (2) has a fastening arrangement (32) which is designed to be fitted into a hollow shaft (40) of a drive unit and to be connected thereto so to transmit a torque from the drive unit via the hollow shaft (40) and the fastening arrangement (32) to the wiper blade (2).
US10214183B2 Method of defogging inner surface of vehicle windshield glass
A method of defogging an inner surface of a vehicle windshield glass. The method includes a first process of defogging by changing a heating, ventilation, and air-conditioning (HVAC) system from a heating mode to a cooling mode when fogging occurs on the inner surface of the vehicle windshield glass; once the inner surface of the vehicle windshield glass is changed to a defogging state by the first process, a second process of pre-defogging by turning off a compressor of the HVAC system for a predetermined period of time under a prescribed condition to prevent flash fogging; and after the second process, when the predetermined period of time elapses, a third process of turning on the compressor to return from the cooling mode to the heating mode.
US10214182B2 In-vehicle communication system, vehicle control device, and communication management device
An in-vehicle communication system includes: a plurality of local ECUs (vehicle control devices) connected to networks of buses, and configured to control an in-vehicle device; an OBDII port which is a communication port to an outside; and an illicit act detection sensor configured to detect an illicit act on a vehicle. Each local ECU includes a reprogramming receiver and a reprogramming controller. The reprogramming receiver receives a reprogramming request signal and reprogramming data from a reprogramming device connected to the OBDII port. Reprogramming for rewriting a software program of a target local ECU is executed according to the reprogramming request signal and the reprogramming data. When the illicit act detection sensor detects an illicit act, the reprogramming controller prohibits execution of reprogramming.
US10214179B2 Steering column assembly having a lock mounting bracket
A steering column assembly includes a jacket assembly and a bracket. The bracket has a first end portion defining a first opening and a second end portion defining a second opening. The second end portion overlaps the first end portion such that the second opening and the first opening are proximately aligned.
US10214177B2 Belt retractor for a seatbelt device
A seat belt retractor for a seat belt device for a vehicle with a belt shaft that is rotatably supported in a belt retractor frame, and a blocking device with a locking catch. A sensor device (2) is provided with a first blocking lever (5) which actuates the locking device based on vehicle deceleration via movement of a first blocking lever (5). A second blocking lever (7) supported on the belt extractor for fixing the first blocking lever (5) when there is a predetermined belt extraction length. A counter gear (3) driven by the belt shaft is provided being formed by an eccentric (27) that drives the belt shaft and a wobble plate (8) having a first toothing (19) that can be driven by eccentric (27) to perform a wobbling movement.
US10214172B2 Vehicle side airbag device
A vehicle side airbag device includes a side airbag, an inner tether that extends in the seat forward direction at the seat width direction inner side of the side airbag in the inflated and deployed state and has a distal end portion anchored to the side airbag, and an outer tether that extends outward in the seat width direction from the seat rear side of the side airbag in the inflated and deployed state and has a distal end portion anchored to the side airbag. An upper end portion of the distal end portion of the outer tether is positioned further toward an upper end side of the side airbag than an upper end portion of the distal end portion of the inner tether.
US10214170B2 Seatbelt mounted combination cutter and glass break tool
A combination seat belt restraint system cutter and glass break tool mounted onto and around the seat belt of an automotive vehicle at a predetermined position for use in cutting the web of the seat belt in the event of a seat belt release latch jam or inoperability resulting in the severing of the seat belt at said position resulting in the tool being freed for use in breaking the glass of a window of the vehicle. The combination tool also being maintained in a fixed position adjacent the safety belt extension/retraction aperture by a strap.
US10214167B2 Electrical wire guide apparatus and sliding door electrical wire guide module
A sliding door electrical wire guide module includes a sliding door and an electrical wire guide apparatus that are integrated with each other. The electrical wire guide apparatus includes: an electrical wire guide body for spanning a distance between a vehicle body and the sliding door and that is capable of undergoing curving deformation; a door-side bracket that is coupled to one end portion of the electrical wire guide body and is fixed to the sliding door; a body-side bracket that is coupled to the other end portion of the electrical wire guide body and is to be attached to the vehicle body, and a lock portion that is formed on the body-side bracket and is detachably locked to a receiving portion provided on the sliding door.
US10214161B2 Wire housing protector
A wire housing protector in which a locking mechanism includes an elastic projecting piece provided in a lid with an engagement protrusion on an outer surface of its leading end, and an elastic projecting piece insertion portion that is provided in a side wall of the protector body, and includes an engagement portion that engages with the engagement protrusion, contact surfaces include first engagement surfaces that each extend from the side wall side of the protector body toward a side to which the engagement protrusion protrudes, second engagement surfaces that extend from end portions of the first engagement surfaces toward the lid side, and third engagement surfaces that extend from end portions of the second engagement surfaces toward the side to which the engagement protrusion protrudes.
US10214158B2 Decorative part for motor vehicles
The present invention relates to a decorative part, comprising an electroplated layer array applied to a plastic substrate. On the electroplated layer array, a PVD layer array having an adhesive layer, a mixed layer and a color-providing cover layer is provided, wherein the mixed layer provides for durability, in particular corrosion protection, and the necessary hardness of the surface.
US10214155B2 On-vehicle image processing device
An object of the present invention is to provide is an on-vehicle image processing device that achieves low cost and provides high mounting accuracy and high electrical adjustment accuracy during a manufacturing process. The on-vehicle image processing device includes a first imaging section, a second imaging section, and an enclosure having the first imaging section at one end and the second imaging section at the other end. The on-vehicle image processing device generates a range image from images captured by the first and second imaging sections. The on-vehicle image processing device further includes an enclosure reference surface that comes in contact with an equipment jig during manufacture, the enclosure reference surface being provided at two locations between the first and second imaging sections.
US10214152B1 Tool-less wedge-type anti-rattle mounting system for a vehicle-mounted equipment carrier
A hitch-type equipment carrier for mounting to a vehicle includes a coupling member, a brace member fixed to the coupling member, and a wedge member that is movable relative to the coupling member. A manually operable actuator is positioned between the brace member and the wedge member. When the coupling member is positioned within the hitch receiver passage, operation of the actuator moves the wedge member in a first direction toward the open end of the hitch receiver passage. The wedge member moves outwardly upon advancement through the open end of the hitch receiver passage. Such transverse movement of the wedge member brings the wedge member into contact with one or more walls of the hitch receiver, which forces the coupling member against one or more of almost walls of the hitch receiver for preventing rattle of the coupling member within the passage of the hitch receiver.
US10214149B2 Bag holder
A shaped elongate strap enables a plastic grocery bag to be used for trash disposal in a vehicle. It has a shaped headrest post gripping top portion at one end and a shaped grocery bag handle gripping portion at the other. The top portion encircles both headrest posts, allowing the strap to drape over the shoulder of the seat so that the bag gripping portion hangs between the seats. The bag gripping portion comprises two spaced-apart hook parts for the bag handles.
US10214143B2 Method for assisting a motor vehicle driver when driving through a narrow passage and/or for maintaining a safe distance from a vehicle in front
A method for supporting a driver of a motor vehicle when driving the motor vehicle through a narrow passage. In order to provide a cost-effective method, the anticipated vehicle path to be covered next is displayed to the driver. The width of the vehicle path shown corresponds to the actual width of the vehicle. If the length of the vehicle path display is realized in a speed-dependent fashion, information regarding the distance from the preceding vehicle arises as a further advantage.
US10214134B2 Illumination device for vehicle
An illumination device for a vehicle, includes: a detection unit that detects a person; an illumination unit that illuminates light in a direction toward a road surface, an illumination region of the light being alterable; and a control unit that, in a case in which a person is detected by the detection unit and there is a possibility of collision between the detected person and the vehicle, controls the illumination unit so as to illuminate light at a region in a range of view of the detected person that is separated from the person by a pre-specified distance, and so as to move the light in a direction of movement of the detected person while maintaining the separation at the pre-specified distance.
US10214132B2 Cargo restraint systems
A kit for securing cargo within an interior of a vehicle is provided. The vehicle has an occupant restraint system including a coupling member. The kit includes a harness having at least one connecting ring. The harness is configured to hold the cargo. The kit includes a first strap having a first connector at a first end releasably coupled to the coupling member and a second connector at a second end coupled to the at least one connecting ring. The kit includes an energy absorbing element defined on the strap between the first end and the second end. The energy absorbing element is deformable to absorb a force acting on the cargo.
US10214130B2 Collapsible organizer for in-vehicle storage
A Collapsible Organizer for in-Vehicle Storage. The organizer provides the driver with a large, stable container for food, drinks and other items. The organizer is attachable to a seat in a vehicle either by hanging from the seat back, or alternatively, by engaging the existing seat belts. The organizer is comprised of a set of movable panels and elements that allow the organizer to be collapsed into a very compact package. The organizer is also easily expandable when desired for use, without the need for tools. The organizer has built-in handles to allow the user to easily remove the organizer from a vehicle and then carry the organizer while the drinks or other items are being held in the organizer. In addition to its ability to safely hold food and drinks, the organizer provides a generous storage area that can be used to store childrens' toys, personal carry items, and portable electronic devices. Finally, the organizer is lightweight, durable, and preferably be made primarily from plastic.
US10214129B2 Air bladder with stacked cell system
A seat includes a seat portion with an air bladder having an outer casing. Multiple fluidly interconnected cells are disposed within a cavity of the outer casing and are configured to inflate the outer casing from a deflated condition to an inflated condition. The cells may be arranged within the air bladder so as to provide a directional inflation of the air bladder from a first portion of the air bladder towards a second portion. First and second support substrates may be disposed within the seat portion, wherein the air bladder is positioned between the first and second substrates. The air bladder may be configured to inflate and displace the first and second substrates relative to one another from an at-rest position to an actuated position. A biasing mechanism may be coupled to at least one of the first and second substrates for biasing the substrates towards the at-rest position.
US10214128B2 Haptic motor
A seat cushion of a vehicle seat includes a cushion made of foam and at least one motor assembly located in the cushion. The at least one motor assembly includes a housing having a first portion and a second portion, and one of the first portion and the second portion includes a meltable feature located near a location of contact of the first portion and the second portion. The meltable feature melts to secure the first portion of the housing to the second portion of the housing to retain a motor within the housing.
US10214123B2 Vehicle seat with cushion plate
A method of assembling a vehicle seat is provided, comprising: providing a seat back frame; forwardly movably connecting a headrest for supporting a head of a seat occupant to the seat back frame; mounting a rear-end collision detector to the seat back frame at a position behind the seat occupant, operatively connecting the rear-end collision detector to the headrest; disposing a link member at a position lateral to the rear-end collision detector; forming a front extending portion that inwardly extends in a right-to-left direction at a front end of a lateral face of the side frame; and forming a rear extending portion that inwardly extends in the right-to-left direction; wherein a protruding portion is formed from a portion of the lateral face of the side frame that faces at least the part of the bracket, the link support shaft being disposed at a same height as the protruding portion.
US10214119B2 Track adjuster
A track adjuster may include a cross member, an end stop bracket, an adjustable end stop lever, and/or a connection member that may be configured to actuate the adjustable end stop lever. The adjustable end stop lever may be configured to rotate between a first position in which the adjustable end stop lever engages the end stop bracket and prevents movement of a seat from a comfort range into an easy entry range, and a second position in which the adjustable end stop does not prevent movement of the seat from the comfort range into the easy entry range. The cross member may be configured for rotating independently of the adjustable end stop lever.
US10214118B1 Systems, methods and apparatuses are provided for automated passenger seat adjustments in a vehicle
Systems, Methods and Apparatuses are provided for a seat adjustment system for a vehicle which includes: a plurality of sensors configured to produce sensor data associated with an occupancy by an internal or external user of a particular seat of the vehicle and a processor, configured to receive the sensor data to: determine a state of one or more settings of the seat adjustment system for the particular seat of the vehicle based on stored data or the received sensor data; determine in a near future whether a particular seat will be occupied by the external user based on the received sensor data; determine currently whether a particular seat is occupied by the internal user based on the received sensor data; and adjust settings of the particular seat in accordance with determinations of the state of settings and occupancy of the particular seat.
US10214117B2 Conveyance seat
A conveyance seat is provided. The conveyance seat comprises a first side frame portion disposed in a first side of a seat width direction extending substantially in an up-down direction, a second side frame portion disposed in a second side of the seat width direction extending substantially in the up-down direction, a drive mechanism configured to generate driving force so as to pivot the first side frame portion and the second side frame portion in the front-rear direction of the seat, a walk-in mechanism disposed in an opposite side of the drive mechanism in the seat width direction across the first side frame portion, a motor fixing portion disposed on the first side frame portion and provided with a fixing surface on which the drive mechanism is secured and a bracket configured to secure the drive mechanism to the fixing surface.
US10214115B2 Multiple EVSE installation with power sharing system for EVSE pairs sharing a circuit breaker
A multiple EVSE installation employs a power sharing system for EVSE pairs which share a common circuit breaker. When only one EVSE is connected to an electric vehicle for charging, the connected EVSE is allowed to charge at full capacity. When a second EV connects to the second EVSE of the pair, while the first EVSE is charging, a controller senses the latter event and issues commands to both EVSE units to limit their current so that the rated circuit breaker capacity is not exceeded. The controller continuously monitors the charging of each of the EVSE units and sends commands to adjust the supply of current to each EVSE accordingly.
US10214112B2 Communications between vehicle and charging system
Methods, devices, and systems are provided for establishing communications between a vehicle and charging system. The communications may include charge request messages sent by or received from the vehicle defining charge particulars, such as, a charge type, charging locations, charging orientation, and/or other information corresponding to charging requirements for the requesting vehicle. The charging system can respond to the charge request messages accepting or denying the vehicle charging request. In response to accepting the request message, the charging system provides charge to the vehicle in accordance with the charge particulars.
US10214111B2 Electrified vehicle power conversion for low voltage bus
An electrified vehicle high voltage battery pack has series-connected battery units or cells combining to provide the high voltage. To power a low voltage bus (e.g., for low voltage accessories or charging a low voltage battery) in a balanced manner, a plurality of DC/DC converters each has an input coupled to a respective battery unit and the converters have respective outputs coupled in parallel to the low voltage bus. A first loop controller receives an actual bus voltage. The first controller generates a target current in response to the bus voltage adapted to regulate the actual bus voltage to a target voltage less than the high voltage. A second controller distributes the target current into a plurality of allocated current commands for respective converters according to respective states of charge of the battery units connected to the converters.
US10214110B2 Power supply device for vehicles
Power supply device includes a power supply circuit with a low voltage load circuit and a high voltage load circuit connected to a plurality of batteries connected in series. A power supply circuit includes an equalizer that can prevent uneven consumption of each battery; a disconnect switch that enables the battery on the low voltage side to be electrically cut off; and a disconnect relay that enables the battery on the high voltage side to be electrically cut off. A machine controller starts an engine controller by turning on an engine key relay after turning on the disconnect relay.
US10214102B2 Dual drive hybrid driveline
A dual drive driveline for a vehicle has a power source, a hydrostatic pump drivingly engaged with the power source, a first axle, a second axle, and a first hydrostatic unit in fluid communication with the hydrostatic pump. The first hydrostatic unit is drivingly engaged or selectively drivingly engaged with the first axle, and the first hydrostatic unit is not drivingly engageable with the second axle. A second hydrostatic unit in fluid communication with the hydrostatic pump, the second hydrostatic unit being drivingly engaged or selectively drivingly engaged with the second axle, and the second hydrostatic unit not being drivingly engageable with the first axle. A control unit is adapted to control a hydraulic displacement of at least one of the hydrostatic pump, the first hydrostatic unit and the second hydrostatic unit.
US10214099B2 Chamber for removing substances from a fluid
A chamber for removing substances from a fluid and particularly for adsorbing fuel vapor from a fuel tank of a vehicle, includes a housing having two ports and a longitudinal axis, an adsorbent material arranged within the housing, the adsorbent material completely covering a transverse cross-section of the housing, such that the adsorbent material forms at least one barrier between the two ports, and a thickness of the adsorbent material in the direction of the longitudinal axis is less than the length of the housing in the longitudinal direction, thereby creating two voids.
US10214098B2 Cap assembly for a carbon canister fuel tank
The cap assembly for a carbon canister fuel tank includes an outer cap and an inner cap. There is a cavity with an opening at the inner cap, and the outer cap is above the inner cap covering the opening. There is a lower vent cap in the cavity which divides the cavity into a filling cavity and a volume cavity. There is a through hole in the center of the lower vent cap with a breathing valve which would open automatically when there is air pressure imbalance in the filling cavity and volume cavity. The first vent hole is at the bottom of the volume cavity, while the second vent hole is at the bottom of the filling cavity. The first vent hole, breathing valve and the second vent hole are arranged in sequence to constitute the exhaust channel for the vaporizing oil gas in the fuel tank.
US10214095B2 Closure system, in particular for a motor vehicle
A closure or grille airflow shutter system, particularly for a motor vehicle includes a first shutter featuring at least one first adjustable shutter element with a first adjustment travel between a first and a second position. A second shutter features at least one second adjustable shutter element with a second adjustment travel between a first and a second position. A shutter coupling couples the first and the second shutters to one another in such a way that the second shutter element is not adjusted or adjusted over a first section of the second adjustment travel, which is smaller than the first section of the first adjustment travel, during an adjustment of the first shutter element over a first section of the first adjustment travel and adjusted over a second section of the second adjustment travel during an adjustment of the first shutter element over a second section of the first adjustment travel.
US10214094B2 Electrical motor construction provided with a planetary gear system
An electric motor construction is provided with a planetary gear system, including an annular thin-rimmed stator (1) as well as a torque takeoff shaft (2) concentric relative thereto. The construction includes inside the stator (1) an annular thin-rimmed rotor (3); a sun gear (4) fixedly coupled to the rotor and concentric with the takeoff shaft (2); an intra-rotor immovably coupled ring gear (5) with a toothed inner surface; planet gears (6) meshing with the ring gear and the sun gear; a planet carrier (7) that the planet gears are supported on; as well as a coupling arrangement (8) for transmitting torque of the rotor optionally directly or by way of the planet carrier to the torque takeoff shaft.
US10214088B2 Systems and methods for an engine mounting device for vehicles
Embodiments disclosed herein describe systems and methods for a universal electric engine mount for vehicles, wherein the universal engine mount may be configured to be installed into at least any front wheel drive vehicle.
US10214082B2 Vehicle door structure
A vehicle door structure includes a reinforcing member that is extended along a side sill on an inner door panel side of a lower portion of an outer door panel. The reinforcing member has a first side surface that faces the side sill in the vehicle width direction, and a second side surface that extends from the first side surface to the outer door panel, and the first side surface and the second side surface are joined to the inner door panel.
US10214080B2 Shade device for vehicle
A shade device for a vehicle includes: a shade; a retracting mechanism attached to a base end of the shade and retracting the shade in a stored state; a stay attached to a tip end of the shade; an extractable constant force spring; a rod, its tip end portion being attached to the stay and its base end portion being connected to the constant force spring, biased in a deploying direction of the shade by biasing force of the constant force spring, and transmitting the biasing force to the stay; a guide rail that stores the rod and an extracted portion of the constant force spring in the stored state of the shade, and guides the rod when the shade shifts from the stored state to the deploying state; and a locking mechanism that locks movement of the rod in the stored state of the shade.
US10214079B2 Vehicular air filter providing high efficiency particle and gas filtration
The present disclosure is directed at a vehicular air filter with relatively high efficiency particle arresting performance along with removal of volatile organic and/or inorganic contaminants. The filter is particularly suitable for hybrid type vehicles.
US10214078B2 AC cut cycles for vehicle air conditioning control based on high ambient temperature
A vehicle heating, ventilating, and air conditioning (HVAC) system can reduce a load applied to a vehicle powertrain during certain conditions. The system can include a fixed compressor operable between an ON state and in an OFF state. Systems and methods can determine whether an engine water temperature meets a forced HVAC recirculation intake threshold. Responsive to determining that the engine water temperature meets the forced HVAC recirculation intake threshold, it can be determined if the engine water temperature meets a high water temperature threshold. Responsive to determining that the engine water temperature meets the high water temperature threshold, it can be determined if an ambient temperature meets an ambient temperature threshold. Responsive to determining that the ambient temperature does not meet the ambient temperature threshold, the compressor can be operated according to an AC cut cycle.
US10214074B2 Servo locking snap feature
Disclosed is a vehicle HVAC system that provides for installation, serviceability, or replacement of at least one actuator servo without removal of the HVAC assembly from the vehicle. As due to the tight space limitations, the present invention provides for at least one fastener-less mounting element of the servo assembly to be attached to the HVAC assembly, without the need for additional fasteners which would require additional space to access with a tool.
US10214070B2 Vehicle height adjustment device
A vehicle height adjustment device includes a changer, a vehicle height controller, and a malfunction detector. The changer is configured to change a relative position of a body of a vehicle relative to an axle of a wheel of the vehicle. The vehicle height controller is configured to change the relative position based on a detection value detected by a detector configured to detect the relative position so as to control a vehicle height, which is a height of the body. The malfunction detector is configured to detect a malfunction in at least one of the changer and the detector, the malfunction causing the vehicle height controller to continue to control the vehicle height to increase.
US10214065B2 Apparatus for toe and/or camber adjustment for a running gear of a motor vehicle
An apparatus for toe and/or camber adjustment for a running gear of a motor vehicle, having a tie rod and/or a link which can be fastened at one side to a bearing fixed with respect to the car body and at the other side by a bearing can be fastened to the wheel carrier of a wheel of the motor vehicle, wherein one bearing has an adjustment element which is in the form of an eccentric and which has an eccentric shaft, which eccentric shaft can be adjusted by an adjustment drive and is assigned safety bearings arranged on both sides of the eccentric.
US10214063B2 Secure trailer coupler
A secure trailer coupler includes an adjustable plate that can be locked in a number of positions to thereby secure the trailer coupler when a trailer is disconnected from or connected to a vehicle. The adjustable plate can be integrated into the base of the trailer coupler such that no pry points are provided. The trailer coupler also includes a locking mechanism that is integrated inside the trailer coupler where it is inaccessible to any would-be thieves.
US10214057B2 Pneumatic tire with chamfered lateral shoulder groove
A pneumatic tire is provided with a tread having a shoulder portion isolated by a main groove, and a slit formed on the shoulder portion, wherein a first tapered portion is formed on a side wall of the slit which comes into contact with the ground first when the tire is rotating, and a second tapered portion is formed on the side wall of the slit which comes into contact with the ground later, an end of the first tapered portion on the main groove side is located at a position closer to the main groove than the end of the second tapered portion on the main groove side, and the second tapered portion is formed so that a width on an opening end of the slit opening at a contact surface is wider than the width of the portion where the second tapered portion is not formed.
US10214055B2 Tyre for vehicle wheels having improved tread pattern
A tire for vehicle wheels having a tread pattern includes: a) two circumferential grooves, which define a first and a second shoulder region, and one central region; b) a plurality of asymmetric transverse grooves having a substantially “V” shape, which extend for the whole width of the tread, including an alternate sequence of a first and a second asymmetric transverse groove defining an alternate sequence of a first and a second asymmetric module; and c) a plurality of lateral transverse grooves, which includes one first lateral transverse groove extending for the whole width of the first shoulder region and for a portion of the central region of the first asymmetric modules, and one second lateral transverse groove extending for the whole width of the second shoulder region and for a portion of the central region of the second asymmetric modules.
US10214053B2 Pneumatic vehicle tire
The invention is directed to a pneumatic vehicle tire having a carcass and a belt built up on the radial outside of the carcass. The tire includes a profiled tread which is built up on the belt on the radial outside of the belt. The belt is formed from at least four belt plies which are arranged one on top of the other from the radial inside to the radial outside. The first belt ply and the second belt ply are crossing working plies. The reinforcing elements of the first and second belt plies are arranged at an angle of 10° to 45° to the circumferential direction. The reinforcing elements of the fourth belt ply are arranged at an angle of 40° to 75° to the circumferential direction and the reinforcing elements of the third belt ply are arranged at an angle of 0° to 5° to the circumferential direction.
US10214052B2 Pneumatic radial tire for passenger vehicles
A run-flat tire of the present invention is a pneumatic radial tire for passenger vehicles which has a carcass composed of plies of radially arranged cords toroidally extending between a pair of bead portions, and the a W/L ratio of the section width W to the outer diameter L of the tire is 0.25 or less.
US10214042B2 Thermal transfer printing
Disclosed is a tool for driving a barbed staple into a workpiece, the tool includes a housing enclosing a power delivery source and a driver blade driven by the power delivery source and comprising an engagement portion configured for engagement with the staple. The tool further includes a nosepiece comprising an aperture providing access for loading a staple into the nosepiece and a passage configured for slidable mounting of the driver blade. In use, the driver blade may be driven along a longitudinal axis of the passage by the power delivery source to engage and drive a staple into a workpiece. Clearances are providing to allow for loading and passage of the barbed staples in the nosepiece and arrangements are provided to maintain the alignment of the staple in the nosepiece to compensate for those clearances.
US10214040B2 Method for marking the surface of a mechanical part with a predefined graphical representation having a holographic effect
A method of marking the surface of a mechanical part with a predefined graphic having a holographic type effect, the method including using a laser source to apply a succession of laser pulses to the outside surface of a part for marking, with different masks being interposed between the laser source and the outside surface of the part, each mask having a particular pattern, each laser pulse having a power density of at least 20 MW/cm2 and a duration that is less than or equal to 100 ns.
US10214031B2 Inkjet print apparatus and recovery method of inkjet print apparatus
The invention provides an inkjet print apparatus and a recovery method of an inkjet print apparatus, which can suppress deterioration of productivity. For that purpose, timing, at which a recovery operation is practiced in accordance with a facing time period of a print head and a print medium and a not facing time period thereof, is set.
US10214025B2 Image processing apparatus and non-transitory computer-readable medium storing image processing program
There is provided an image processing apparatus including a controller configured to execute: causing a printing execution unit to execute printing of a first test image and a second test image; acquiring first scan image data; acquiring second scan image data; identifying a first boundary; identifying a first number of pixels and a second number of pixels; calculating a first number of unit pixels and a second number of unit pixels; calculating a relevant value related to density of a dot formed by each nozzle; and generating characteristics data which indicates ink jetting characteristics of N pieces of nozzle.
US10214024B2 Liquid ejecting apparatus
A liquid ejecting apparatus includes: a liquid ejecting head having a nozzle that ejects liquid; a supply flow path that supplies the liquid to the liquid ejecting head; a pressurizing mechanism that pressurizes a region which communicates with the supply flow path; a decompression mechanism that decompresses the region pressurized by the pressurizing mechanism; and a resistor section that interferes with decompression by the decompression mechanism.
US10214021B2 Liquid cartridge provided with connecting channel providing communication between liquid supply chamber and liquid storage chamber
A liquid cartridge includes: a liquid container including a liquid storage chamber; a liquid supply portion including a liquid supply chamber and first and second openings; a movable member; a sealing member; and a connecting channel. The first opening provides communication between the supply chamber and an exterior of the cartridge. The second opening provides communication between the supply chamber and the storage chamber. The movable member extends in the storage chamber and the supply chamber. The sealing member intimately contacts the movable member and the liquid supply portion continuously in a circumferential direction. The connecting channel is formed in the movable member and provides communication between a space in the supply chamber and the storage chamber so that liquid can flow therebetween. The connecting channel opens into the storage chamber at a position further downward than the second opening when the cartridge is in an attached posture.
US10214013B2 Acoustophoretic printing apparatus and method
The present invention contains a printing apparatus and a method, e.g., for ejecting inks (i.e., pure liquids, mixtures, colloids, etc.) for a very broad range of physical properties (such as viscosity). Acoustic forces 3a may be generated by an emitter 1 and a reflector 2 to detach droplets 10 from a nozzle 6. The ink may be advanced through the nozzle 6 by a standard back pressure system 5. A reflectorless chamber 7 may enhance acoustic forces 8a and the droplets 10 may be ejected at a bottom 9 of said chamber 7, so that droplets 10 may be deposited on any substrate 11.
US10214012B2 Liquid ejecting apparatus and method of forming adjustment pattern
A liquid ejecting apparatus includes a head unit that ejects ink onto a medium, a transport unit that transports the medium, and a control unit that forms an adjustment pattern on the medium, and the control unit forms, as the adjustment pattern, a pattern including a first pattern that is formed in a transport direction, a plurality of scales that are formed in the transport direction, and a second pattern that is formed at a position corresponding to the scales in the transport direction while the position thereof in a main-scanning direction that intersects the transport direction is changed.
US10214010B2 Liquid discharge device and inkjet printer including the same
A driving signal generating circuit generates, for each driving period, a main driving signal including a first sub driving signal including a first driving pulse, a second sub driving signal including a second driving pulse, and a third sub driving signal including a third driving pulse. The third sub driving signal follows the second sub driving signal. A driving signal supplying circuit includes a second dot former to supply the second sub driving signal and the third sub driving signal to an actuator coupled to a defining plate defining a portion of a pressure chamber, without supplying the first sub driving signal to the actuator. The third driving pulse starts after a lapse of a preset time from the start of the second driving pulse. The preset time is equal to a value of about p×Tc, where p is greater than 2.
US10214008B2 Circuit for driving printer actuating elements
A circuit for driving first and second groups of actuating elements for ejection of droplets from a printhead, the circuit comprising: a drive circuit configured to provide a drive waveform to first electrodes of the first and second groups; and a voltage offset circuit configured to provide a voltage offset to the second electrodes of the first or second groups to bias the second electrodes of the first and second groups relative to each other.
US10213998B2 Assembly and process for preparing affixing tape
This disclosure relates generally to an assembly and process for preparing affixing tape. The disclosure also relates to an affixing assembly and process using the prepared tape. The tape can be used, for example, to affix plastic items to mailing pieces. The assemblies and processes disclosed herein provide for added throughput, less down time, higher quality of parts and production control.
US10213994B2 Methods for manufacturing spar caps for wind turbine rotor blades using thermoplastic-based composite plates
In one aspect, a method for manufacturing a spar cap for a wind turbine rotor blade may generally include stacking a plurality of plates together to form a plate assembly, wherein each of the plates is formed from a fiber-reinforced composite including a plurality of fibers surrounded by a thermoplastic resin material. The method may also include positioning the plate assembly relative to a mold defining a mold surface, wherein the mold surface is shaped so as to correspond to at least one blade parameter of the wind turbine rotor blade. In addition, the method may include applying pressure to the plate assembly via the mold such that at least a portion of the plate assembly conforms to the shape of the mold surface.
US10213990B2 Methods to make stretchable elastic laminates
Stretchable elastic laminates having an improved cloth-like appearance, as well as methods of preparing the laminates, are disclosed herein. Particularly, the present disclosure is directed to methods of preparing tissue-elastic laminates with uniform tissue fractures as the laminate is stretched 50%, or even 100%, or more in at least one of the machine direction (MD) or cross direction (CD).
US10213988B2 Coated article having low-E coating with IR reflecting layer(s) and niobium-doped titanium oxide dielectric layer(s) and method of making same
A coated article includes a low emissivity (low-E) coating having at least one infrared (IR) reflecting layer of a material such as silver, gold, or the like, and at least one high refractive index layer of or including titanium oxide and at least one additional metal. A doped titanium oxide layer(s) is designed and deposited in a manner so as to be amorphous or substantially amorphous (as opposed to crystalline) in the low-E coating, so as to better withstand optional heat treatment (HT) such as thermal tempering and reduce haze. The high index layer may be a transparent dielectric high index layer in preferred embodiments, which may be provided for antireflection purposes and/or color adjustment purposes, in addition to having thermal stability.
US10213986B2 Electric connection and method of manufacturing the same
An electric connection is provided, and has a first copper (Cu) layer, a second Cu layer, and a composite metal layer disposed between the first Cu layer and the second Cu layer. The composite metal layer has 0.01 wt. %≤gallium (Ga)≤20 wt. %, 0.01 wt. %≤copper (Cu)≤50 wt. %, and 30 wt. %≤nickel (Ni)≤99.98 wt. %. Moreover, a method of manufacturing the electric connection is provided, and has the steps of: (1) providing a first Cu layer and a second Cu layer; (2) forming a first Ni layer on the first Cu layer; (3) forming a second Ni layer on the second Cu layer; (4) forming a Ga layer on the first Ni layer; and (5) keeping the second Ni layer in contact with the Ga layer and carrying out a thermo-compress bonding therebetween to form the electric connection.
US10213979B2 Electric press, bend-point detection method, and program
A detection unit for detecting a press position and a load at the press position; an input/storage unit for inputting and storing a value serving as a reference for determining a bend point in a relation between the press position and the load at the press position; a slope calculation unit for calculating a slope of the load based on the press position and the load at the press position, which have been detected; and a bend-point determination unit for determining a point, at which the calculated slope of the load exceeds the value serving as the reference for determining the bend point, as the bend point are provided.
US10213978B2 Waste material rebaler with side loading and retrieval
A method of forming a higher density bale of waste paper from two or more lower density bales of waste paper includes positioning the lower density bales intact and in side-by-side relationship with respect to each other, moving them to a compression zone, and compressing the bales together in the compression zone to form a higher density bale. The higher density bale can then be strapped to maintain its higher density configuration and shape. Thus, a larger tonnage of waste paper in bales can be loaded into a shipping container for transport. A rebaler for carrying out the method includes side feed and side retrieval of bales, significantly improving over traditional top feed machines.
US10213975B2 Automatic system and method for mounting and dismounting tire casing on expandable rim hub in retreading operations
A loader device includes a support pedestal movable over a range of longitudinal travel along a longitudinal axis, a support carriage movably mounted to the support pedestal, a loader actuator, and a dismount actuator. The support carriage is movable over a range of vertical travel along a normal axis, which is perpendicular to the longitudinal axis. The support carriage has a support arm adapted to support a tire casing. The loader actuator and dismount actuator are respectively adapted to selectively move: (1) at least a portion of a tire casing supported upon the support carriage in a loading direction along the longitudinal axis off of the support arm onto the expandable rim hub and (2) at least a portion of a tire casing supported upon the expandable rim hub in an opposing unloading direction off of the expandable rim hub and onto the support arm of the loader device.
US10213973B2 Composite rail tie apparatus and method
A railroad crosstie (tie) may be fabricated from a composite material including a fiber reinforced polymer shell manufactured by pultrusion or other process, and filled by a suitable material, typically selected from expanded elastomeric polymer (such as polyurethane resin or other polymer), concrete, lightweight concrete formed by conventional aggregate, sand, cement, water, and an ultra light filler such as natural materials, sawdust, beads of expanded polymer such as expanded polystyrene, microspheres of glass or plastic, a recycled wooden tie in conjunction with any of the above, or the like. Fasteners may be driven such as spikes, threaded, such as screws, lag screws, spreading screws, rivets, or the like into apertures, pilot holes, or directly into fill absent apertures therein.
US10213972B2 Fiber composite laminate and method for producing a fiber composite laminate
A method for producing a fiber composite laminate, including the steps of applying pressure and/or heat to a first preform, which has one or more dry fiber layers and a thermoplastic elastomer, such that the thermoplastic portion of the thermoplastic elastomer completely impregnates the dry fiber layers of the first preform in at least one first region and only partially impregnates the dry fiber layers in at least one second region and, in a thermosetting polymer matrix, impregnating and curing the fiber layers of the second region of the first preform that are still dry and have not been impregnated with the thermoplastic portion of the thermoplastic elastomer.
US10213971B2 Forming machine for forming a hollow body, in particular a casing of a solid propellant engine, and deposit head for such a forming machine
In a machine for forming a hollow body, for example a casing of a solid propellant engine, a tensioned and guided belt comprising a layer of adhesive material and a protective strip is fed from a deposit head, supported by a robot and comprising an unwinding device for unwinding the belt, a winding device for winding the strip, a first pressing roller for pressing the strip and the layer of adhesive material and rotatable about an axis thereof orthogonal to the feed path of the belt and a second pressing roller for pressing the adhesive material and the strip, rotatable about an axis thereof forming an angle other than 90° to the feed path and movable in opposite directions in a direction transversal to feed path.
US10213969B2 Integrated smart susceptor heater blanket and vacuum bag deployment system for large composite skin laminate debulk
A processing apparatus such as a heating and/or debulking apparatus that may be used to debulk a plurality of uncured composite layers to form an article such as an aircraft component may include a plurality of interconnected smart susceptor heater blankets. The plurality of smart susceptor heater blankets may be connected in series or in parallel, and may be controlled to uniformly heat the component during formation. The plurality of smart susceptor heater blankets may be supported by a deployment system that lowers the plurality of smart susceptor heater blankets toward, and raises the plurality of smart susceptor heater blankets away from, a working surface.
US10213961B2 Plastic-metal hybrid component and method for producing same
The invention relates to a plastic-metal hybrid component and to a corresponding method for producing a plastic-metal hybrid component. The production method has the following steps: (i) providing a fiber composite semifinished product based on polyamide, at least one part of the surface of the semifinished product being made of a polymer composition which contains the following: a) 100 wt. % of a polyamide; and b) 0.5 to 20 wt. % of one or more adhesive additives of the formula (I); (ii) providing a metal main part; (iii) optionally pretreating the surface of the metal main part in order to produce functionalities; (iv) introducing the main metal part and the fiber composite semifinished product into a pressing tool and closing the tool; and (v) bonding the fiber composite semifinished product and the metal main part by means of a compression process under the effect of pressure and temperature.
US10213960B2 Plasticity induced bonding
Methods and apparatuses for bonding polymeric parts are disclosed. Specifically, in one embodiment, the polymeric parts are bonded by plastically deforming them against each other while they are below the glass transition temperatures. A method includes: placing a first polymeric part in contact with a second polymeric part; and plastically deforming the first polymeric part and the second polymeric part against each other to bond the first polymeric part to the second polymeric part. Additionally, during the plastic deformation, a temperature of the first polymeric part is less than a glass transition temperature of the first polymeric part and a temperature of the second polymeric part is less than a glass transition temperature of the second polymeric part.
US10213955B2 Stamping device
A stamping device for base materials includes: a first roller with at least one stamping pattern region at an outer surface thereof; a second roller at a first side of the first roller with a first stamping gap therebetween; a third roller at a second side of the first roller with a second stamping gap therebetween; a first delivery mechanism configured to, when the stamping pattern region rotates to a first position corresponding to the first stamping gap, deliver a base material to a first material-supplying side of the first stamping gap to stamp the base material; and a second delivery mechanism configured to, when the stamping pattern region rotates to a second position corresponding to the second stamping gap, deliver another base material to a second material-supplying side of the second stamping gap so as to stamp the another base material.
US10213954B2 Natural path forming for composite material
A method includes the step placing composite laminate material onto a three dimensional forming tool with an external surface and at least four junctures associated with the external surface. Each juncture is positioned between two adjacent planar surfaces in which each of the two adjacent surfaces extend in a different plane, the junctures converge and each juncture defines a line of direction. The three dimensional forming tool arranged in a two dimensional pattern, has the lines of direction and the two adjacent planar surfaces positioned on opposing sides of each of the at least four junctures are all positioned in a common plane. The line of direction of each of the at least four junctures in the two dimensional pattern converge to a common point. At least one line of direction is not in alignment beyond the common point with another line of direction. Tool apparatus is also provided.
US10213948B2 Hot melt fragmentation extruder and process
A co-rotating twin screw extruder for forming fragments is disclosed. The extruder comprises of an intake zone for receiving one or more excipient(s) suitable for oral dosage or one or more excipient(s) suitable for oral dosage along with one or more active pharmaceutical ingredient, a melt zone for softening at least one excipient to form a viscous mass or melt and a fragmenting zone for fragmenting and cooling the viscous mass into cooled fragments and an extruder outlet for recovering the cooled fragments from the extruder.
US10213947B2 Injection device and resin injection method
As an injection screw 2 applies pressure, a holding pressure plunger 22 is moved backward under the pressure of a resin to flow the resin into a holding pressure path 9, and the resin in a resin path 6 is pressurized (primary holding pressure process). A shutoff plunger 12 is closed, and the resin in the resin path 6 and the holding pressure path 9 is pressurized by the holding pressure plunger 22 (secondary holding pressure process). Further, the shutoff plunger 12 is opened, and the holding pressure plunger 22 is moved forward until its tip projects into the resin path 6 to discharge all the resin in the holding pressure path 9 to the resin path 6, whereby the resin beside the injection screw 2 as compared with the shutoff plunger 12 is held with respect to the holding pressure path 9.
US10213942B2 Method of loading and unloading a mold on a foam plastics molding machine
On a foam plastics molding machine, a molding unit, defined by a mold and an interface frame equipped with a number or quantity of plastic molding material and operating fluid inlets, is loaded into a raised window in a fixed frame of the machine by positioning the molding unit in a fixed position on a trolley; positioning the trolley astride a fixed platform; raising the platform so that vertical ribs on the interface frame slidably engage corresponding vertical guides forming part of the machine and on a level with the window; connecting the guides to the ribs; and moving the guides towards the window.
US10213941B2 Granulating device with cutting knife head
A granulating device having a cutting knife head for cutting strands of melt into granules in a granulator housing. A perforated plate with die openings, from which strands of melt is extruded into the granulator housing, projects into the granulator housing. The cutting knife head, which has at least one cutting knife arranged radially on its outer circumference, is driven by a rotating drive shaft. The granulator housing has a first coolant inlet and an outlet for a mixture of coolant and granules. In addition, the granulator housing has a second coolant inlet that is independent of the first coolant inlet and that supplies a coolant flow for direct granule cooling to at least one co-rotating cooling nozzle bore in the cutting knife head through a coolant chamber and a stationary coolant pipe oriented coaxially to the drive shaft.
US10213935B2 Apparatus and method for cutting products
Apparatus for cutting products, comprising: a base; a cutting head rotatably fitted to the base; an impeller adapted for rotating concentrically within the cutting head to urge products fed into the cutting head towards the circumference of the cutting head by means of centrifugal force; an impeller drive mechanism for driving the rotation of the impeller at an impeller rotational speed setting the centrifugal force; and a cutting head drive mechanism for driving the rotation of the cutting head at a cutting head rotational speed which is greater than the impeller rotational speed.
US10213933B2 Synthetic turf seam integration template system and methods of use
A synthetic turf seam integration template system and method is provided that includes a template having a planar base with a perpendicularly joined positioner. The planar base is configured with a longitudinal cutting edge with a predetermined curvature and an opposing longitudinal non-cutting edge. The positioner, which aids in moving the template, is attached to the non-cutting edge. Variations of the predetermined curvature patterns are disclosed. An optional connector allows connection of two templates to create a longer template for usage on longer seams. Also disclosed are methods of using the seam integration tool in creating an undetectable seam in synthetic turf.
US10213929B2 Vibrissa and eyebrow scissors having fixed blade and moveable blade capable of being rinsed separately
The disclosure provides a pair of vibrissa and eyebrow scissors having a fixed blade and a moveable blade capable of being rinsed separately. The pair of vibrissa and eyebrow scissors comprises a scissors head and a scissors body, wherein a driving device is arranged in the scissors body. The scissors head further comprises a blade separation device; the blade separation device is connected with the fixed blade or the moveable blade; and by operating the blade separation device, the fixed blade and the moveable blade that are in a laminating state are separated from each other. On the basis of the traditional vibrissa and eyebrow scissors, the disclosure is provided with a blade separation device which may separate the moveable blade from the fixed blade, so that the rinsing effect can be enhanced.
US10213927B2 Utility knife
A utility knife includes a shell including first and second shell bodies releasably assembled together. A compartment is defined by the first and second shell bodies. A channel is defined at a distal end of the first shell body of the shell and is disposed outside of the compartment. A blade carrier assembly releasably engages with a blade and includes a seat movably received by compartment of the shell. The blade carrier assembly is operably movable to a first position in which the blade is in a retracted position and not extending out of the shell and, to a second position in which the blade is in an exposed position and extending out of the shell. The blade carrier assembly in the second position thereof is also guided by the channel.
US10213926B2 Gripping device with locking arrangement
In a gripping device including carriages disposed on a base body so as to be movable relative to each other by a motor drive, the carriages being provided with gripping elements which are movable with the carriages between an opening and a closing position of the gripping elements, at least one of the gripping elements is supported on the respective carriage so as to be able to yield to a certain engagement pressure force which is adjustable in the range of 5 to 300 N in order to prevent excessive damage or injuries-causing engagement forces.
US10213925B2 Workpiece contact state estimating device and workpiece contact state estimation method
The present invention provides a workpiece contact state estimating device and a workpiece contact state estimation method to estimate an actual state of contact of a workpiece A with a peripheral object on the basis of a feasible contact acting force range, which is a feasible range of the value of a contact acting force (the force acting on a manipulator 1 generated by contact) prepared in advance for each of a plurality of types of contact states that are feasible as the states of contact of the workpiece A with the peripheral object, and a measurement value of the contact acting force at the time of contact of the workpiece A with the peripheral object.
US10213919B2 Flexible tools and apparatus for machining objects
A flexible tool comprising: a plurality of rigid members spaced along a longitudinal axis; a plurality of flexible members extending between the plurality of rigid members and being arranged to enable the plurality of rigid members to diverge from the longitudinal axis and define a work volume for the flexible tool, at least some of the plurality of flexible members being unevenly spaced around the longitudinal axis, and/or a physical characteristic of at least some of the plurality of flexible members varying along the longitudinal axis, to cause the work volume and/or stiffness of the flexible tool to be asymmetric relative to the longitudinal axis.
US10213914B2 Blow molding toolbox
A blow molding toolbox has a casing, a cover, and multiple reinforcing elements. The casing has multiple connecting recesses, multiple guiding slots, and multiple positioning recesses. The connecting recesses are deposited on an external surface of the casing at corners of the casing. The cover is pivotally connected to the casing and has a same structure as the casing. Each one of the reinforcing elements is connected to the casing at one of the corners of the casing to cover a corresponding connecting recess of the casing or is connected to the cover at one of the corners of the cover to cover a corresponding connecting recess of the cover, and each reinforcing element has a body, at least one fixing tube, and at least one tapping screw. The reinforcing elements may increase the structural strength of the blow molding toolbox.
US10213913B2 Tool storage assembly
There is provided a tool storage assembly. The assembly includes a plurality of modular bases. The bases are selectively connectable together at peripheral side portions thereof. The assembly includes a plurality of retaining members coupled to the bases. The assembly includes a plurality of actuators each associated with a respective ones of the retaining members. Selective actuation of selective ones of the actuators releases corresponding selective ones of the retaining members. Remaining ones of the retaining members form a plurality of customized storage receptacles thereafter.
US10213910B2 System and method for buckle release assistive device
This invention relates in general to restraint systems for automotive vehicles and more particularly, to systems and methods for an assistive device including a C-shaped tool for use in depressing the actuator button of a car seat restraint harness to assist in unlocking the buckle.
US10213909B2 Vehicle driveline servicing apparatus and method
An apparatus to service the driveline of a vehicle is presented. The apparatus includes two members, a pivot element, and a bridge lock. The members each have an elongated handle segment and a jaw segment. The pivot element is configured to pivotally connect both members together near the jaw segments. The bridge lock is configured to be movably positioned along the handle segments. The jaw segments combine to define a profile which is adapted to secure to the splined coupling interface of a vehicle propeller shaft. The bridge lock is adapted to provide holding pressure to the handle segments, so as to lock the jaw segments when secured to the splined coupling interface.
US10213908B2 Adapter for power tool devices
An adapter for a power tool including a housing, a tool-side connector, and a battery-side connector in electrical communication with each other. The tool-side connector is configured to couple to a power tool, and the battery-side connector is configured to couple to a battery pack. The adapter also includes a communication interface configured to couple with an external device, and a controller. The controller is configured to determine a state of the power tool, operate in a data transmission mode when the power tool is in the idle state, operate in a pass-through mode when the power tool is in the active state, and switch between the data transmission mode and the pass-through mode based on the state of the power tool.
US10213904B2 Grinding wheel tool
This grinding wheel tool is provided with a cylindrically shaped head unit comprising a hollow area passing through the inside, and abrasive grains adhered across the entire outer peripheral surface of the head unit. A fluid is supplied in the hollow area, and in the head unit, communication holes are formed which communicate between the hollow area and the outer peripheral surface and which, from the radial direction of the head unit, are angled forwards in the direction of rotation. Hereby, it is possible to provide a grinding wheel tool which can greatly reduce clogging even in cases where a high amount of cutting chips are generated per unit time, such as in high-feed processing.
US10213899B2 Fluid jet cutting device
A fluid jet cutting device (10) for sectioning materials is provided. The device includes a compact and portable body (12) having an equipment chamber (14) accessible through a first panel (20), a working chamber (16) accessible through a second panel (22) and a receptacle (18) in communication with the working chamber. A pump assembly (26) and motor (28) are removably positioned on a base (32) in the equipment chamber. A guide assembly (36) is positioned in the working chamber and a cutting head (38) having a nozzle (50) is movably coupled to the guide assembly for movement along three axes. A drive assembly (52) moves the cutting head along the guide assembly. A clamp (56) for holding a work piece includes a first face (58) and a second face (60) movable relative to the first face so as to secure regular, irregular or complex shaped work pieces. A basket (66) is positioned in the receptacle below the clamp and the device may be controlled by way of a touch screen user interface (72).
US10213894B2 Method of placing window in thin polishing pad
A polishing pad includes a polishing layer stack that has a polishing surface, a bottom surface, and an aperture from the polishing surface to the bottom surface. The polishing layer stack includes a polishing layer that has the polishing surface. A fluid-impermeable layer spans the aperture and the polishing pad. A first adhesive layer of a first adhesive material is in contact with and secures the bottom surface of the polishing layer to the fluid-impermeable layer. The first adhesive layer spans the aperture and the polishing pad. The light-transmitting body is positioned in the aperture and has a lower surface in contact with, is secured to the first adhesive layer, and is spaced apart from a side-wall of the aperture by a gap. An adhesive sealant of a different second material is disposed in and laterally fills the gap.
US10213890B2 Deburring device for back cavity of wheel
Disclosed is a deburring device for a back cavity of a wheel, composed of a machine frame, a clamping and rotating system, a rising and falling translation system and brush units. Jaws clamp a wheel on a roller way, upper cylinders enable the wheel to rise through four upper guide posts, and a first servo motor enables the wheel to move to upsides of conical sleeves through a second gear rack and a second gear; the upper cylinders enable the wheel to fall, and outer sides of the four jaws are in fit with the conical sleeves; a second motor enables the wheel to rotate in a clamped state; a first motor drives a bottom plate and a brush system to rotate in a circumferential direction through a first synchronizing belt; a second servo motor drives a first brush to rotate, a third servo motor drives a second brush to rotate, and brush hairs of the two brushes apply brushing forces of different directions to a back cavity of the wheel; a direction of rotation of the wheel is opposite to that of the brush system; and lower cylinders enable the brush system to rise through lower guide posts, and the brush system can carry out deburring when the brush system is in contact with the back cavity of the wheel.
US10213887B2 Turret tool post and machine tool equipped with turret tool post
A turret tool post includes a turret turnably supported by a post body, turret turning part having a turret turning shaft and the like to turn the turret, a tool attachment part turnably holding a rotatable tool and attached to the turret, and tool-attachment-part turning part turning the tool attachment part to turn the rotatable tool. The tool-attachment-part turning part and the turret turning part are provided independently and arranged to face each other. The tool-attachment-part turning part includes a tool turning motor installed inside the turret and an attachment-part transmission shaft connected to the tool turning motor.
US10213886B2 Method for making tools and/or handling equipment available, and associated devices
The invention relates to a method and a device for making tools and/or handling equipment available for a treatment machine, wherein a mobile magazine contains at least two different types of tools and/or handling equipment together.
US10213885B2 Electromagnetic base for magnetic drill press
A drill press includes a main housing, a drill unit supported by the main housing for relative movement therewith, and a magnetic base for coupling the drill press to a ferromagnetic workpiece. The magnetic base includes a ferromagnetic body having spaced, substantially parallel first and second rails. Each of the first and second rails includes a flat bottom surface engageable with the ferromagnetic workpiece. A coil is positioned between the first and second rails for generating a holding force on the ferromagnetic workpiece. The coil defines a central axis that is parallel with the bottom surface of each of the first and second rails.
US10213884B2 Automated assembly method and automated assembly apparatus
An automated assembly apparatus, characterized by comprising an assembly robot having a plurality of hands, the plurality of hands being movable in an X-axis direction and a Y-axis direction by an X-axis moving unit and a Y-axis moving unit, and a plurality of workbenches which are provided with Z-axis moving unit and which are movable in a Z-axis direction by the Z-axis moving unit. A work area is independently provided for the plurality of workbenches, a width of a predetermined work area among the work areas is larger than clearance widths of the plurality of hands, widths of the work areas other than the predetermined work area are smaller than the clearance widths of at least some of the plurality of hands, and the hand which performs a job on the predetermined work area is disposed at a lowermost level in the Z-axis direction.
US10213875B2 Method for manufacturing a housing of a turbomachine
A method for manufacturing a housing of a turbomachine, in particular a housing of a radial turbo compressor. The method includes the following steps: a) providing a hollow body that is closed in a circumferential direction and extends along an axis; b) coating the inner side of the hollow body with a corrosion-resistant layer that is more resistant to corrosion than the material of the hollow body; c) dividing the hollow body into two half-shells along the axis in a separation joint plane; d) assembling the housing by joining both half-shells and fastening both half-shells in the region of the separation joints, which were created by separation, by means of detachable fastening elements.
US10213872B2 Machining head and machining device
A processing head (1) for surface processing by means of a laser beam is disclosed. The processing head (1) comprises a through passage (2) for a laser having a longitudinal axis (A), at least one powder supply passage (3) and a cooling passage (4) for cooling the processing head (1). The processing head (1) is at least configured of two parts and comprises a body (5) and a sleeve (6). The sleeve (6) is suitable for the arrangement at the body (5). The through passage (2) of the laser and the powder feed channel (3) are configured in the body (5). The body (5) at least partly forms a first sidewall of the cooling passage (4). The sleeve (6) at least partly forms a second sidewall of the cooling passage (4).
US10213871B2 Method and apparatus for marking an article
The invention is a method and an apparatus for marking an article and the article thus marked. It includes providing the article. Generating a plurality of groups of laser pulses. At least one of the plurality of groups is generated by modulating a beam of laser pulses to form a plurality of beamlets. Each, of the plurality of beamlets, include at least one laser pulse. It also includes directing the plurality of groups of laser pulses onto the article such that laser pulses within the at least one of the plurality of groups impinge upon the article at spot areas that do not overlap one another, wherein laser pulses within the plurality of groups are configured to produce a visible mark on the article.
US10213870B2 Optical lenses for laser marking
An optical lens for laser marking includes a first lens (L1), a second lens (L2), and a third lens (L3), which are successively coaxially arranged along a transmission direction of incident light, wherein the first lens (L1) and the second lens (L2) are meniscus lenses, and the third lens (L3) is a biconvex lens; wherein the first lens (L1) has a first surface (S1) and a second surface (S2), the second lens (L2) has a third surface (S3) and a fourth surface (S4), the third lens (L3) has a fifth surface (S5) and a sixth surface (S6); the first surface (S1) to the sixth surface (S6) are successively arranged along the transmission direction of the incident light; wherein radii of curvature of the first surface to the sixth surface are −47±5% mm, ∞, −218±5% mm, −81±5% mm, 778±5% mm, and −142±5% mm, respectively; wherein central thicknesses of the first lens, the second lens, and the third lens are 4±5% mm, 15±5% mm, and 18±5% mm, respectively. The optical lens for laser marking not only has high engraving quality, but also has a high engraving speed with a higher efficiency than conventional engraving lens.
US10213867B2 Tip dresser blade
Provided is a tip dresser blade blank comprising a casting of M-2 steel hardened to a Rockwell C hardness in the range of 63 to 66, inclusive, by double tempering. The casting may be ground to provide a specific first geometry or a specific second geometry.
US10213865B2 Method for welding a case hardened component
A method for producing a welded part from two components, where at least one of the components has a hardened surface. The method can include case hardening the surface of one of the components using a salt bath nitriding process and then welding the case hardened first component to the second component by gas metal arc welding (GMAW).
US10213862B2 Welding system for determining a quality of a welding operation
A welding system includes a repositionable temperature sensor. The repositionable temperature sensor is configured to detect temperatures corresponding to a workpiece and to provide temperature data corresponding to the detected temperatures. The welding system also includes a power supply configured to receive the temperature data from the temperature sensor. The power supply is configured to modify control of an output of the power supply based on the detected temperature.
US10213861B2 Automated system for machine set-up of welding power sources and welding systems
A system for re-configuring a welding system provides the ability to download applications to a welding power source or system, and to store the configuration data and applications to one or more of a series of welders, thereby simplifying configuration and re-configuration of power sources.
US10213855B2 Methods and systems for forming aligned holes
A method for forming a plurality of aligned holes includes aligning a first surface defining a first hole with a second surface defining a second hole, wherein the first hole at least partially aligns with the second hole to form a gap. A virtual hole diameter is measured, wherein the virtual hole diameter is a diameter of a virtual hole through the gap and the virtual hole diameter is a smallest bisector of the gap. Responsive to the virtual hole diameter having a first virtual hole diameter, a first cleanup hole having a first cleanup hole diameter is formed through the gap, wherein the first cleanup hole is concentrically aligned with the virtual hole. A first fastener having a first size is inserted into the first cleanup hole, and the first surface is attached to the second surface using the first fastener. Additional implementations are described.
US10213854B2 Band saw blade
A band saw blade can include a blade body having a longitudinally extending back edge along one side and a cutting edge defined by multiple teeth on an opposing side of the blade body. Each tooth can have tip, a rake face disposed along the front side of the tooth, and a relief surface disposed along the opposing rear side of the tooth. A gullet can be disposed between each pair of teeth and can extend from the rake face of one tooth to the relief surface of the next adjacent tooth in the cutting direction. A notch can be defined by the junction of the rake face and the gullet. The rake face can be disposed at a positive angle and with the notch can promote the movement of swarf generated by the tip cutting a work piece into the gullet.
US10213848B2 Chip control tool
A rotary tool comprises a cylindrical sleeve including an opening formed in an outer circumferential surface thereof providing fluid communication between a hollow interior of the sleeve and an environment surrounding the sleeve. The sleeve includes an axially extending flow passage formed therein terminating in a first fluid outlet formed in an open end of the sleeve disposed adjacent a cutting element of the rotary tool. The fluid outlet is configured to deliver a flow of a fluid toward the workpiece to cause chips formed during the machining operation to be directed away from the workpiece and out of the hollow interior of the sleeve through the opening formed in the outer circumferential surface thereof.
US10213847B2 Chamfering tool, tool support set and chamfering system
A chamfering tool that chamfers an opening edge of a target hole formed in a work, the chamfering tool including a support shaft, a base shaft having the support shaft on a tip end side thereof and being eccentric with respect to the support shaft, and a blade portion having a rake face that is a step surface of a step protrusion portion protruded laterally from the support shaft or that is an end surface of the support shaft. The blade portion including an edge line in a shape of a curve and being bulged to a side away from a center axis of the support shaft, and the edge line being inclined with respect to an axial direction of the support shaft.
US10213842B2 Method for achieving length accuracy of diamond turned parts
A temporary part is mounted onto the chuck of the diamond turning machine. A diamond turning tip of the diamond turning machine is used to form a reference surface on the temporary part, registering a baseline for a motion control system of the diamond turning machine. While the temporary part remains mounted to the diamond turning machine, a workpiece is mounted onto the temporary part, and the diamond tip is controlled relative to the reference surface to diamond turn a surface profile on the workpiece. Because the baseline established by the reference surface compensates for positional variations from mounting parts directly onto the chuck of the diamond turning machine, the length of the workpiece can be shaped to a designated length with a high degree of accuracy.
US10213837B2 Titanium powder containing solid-soluted nitrogen, titanium material, and method for producing titanium powder containing solid-soluted nitrogen
A method for producing titanium powder containing a solid-soluted nitorogen comprises the step of heating titanium powder comprised of titanium particles in a nitrogen-containing atmosphere to dissolve nitrogen atoms and form a solid solution of nitrogen atom in a matrix of the titanium particle.
US10213831B2 Construction of a 3D printing device for producing components
The invention relates to a device for producing three-dimensional models, comprising a coater, which includes an ejection opening, at least one print head, which is mounted on a print axis, the ejection opening of the coater being disposed toward the top in the coating direction, and the print head being disposed counter to the coating direction with the opposite orientation on the printing axis behind the coater in the coating direction; the invention also relates to a method for producing three-dimensional models.
US10213829B2 Cylinder liner and method for producing same
Disclosed is a cylinder liner having a high bonding strength to a cylinder block. Further disclosed is a method for producing the same. The cylinder liner uses a silicon-aluminum alloy as a material; a plurality of protrusions are formed on the external surface thereof; and the protrusions each contain a pillar section extending from the external surface, and a head section formed at the end of the pillar section.
US10213826B2 Systems and methods for providing prosthetic components
Methods for forming prosthetic implants, including femoral implants, are discussed. While the methods can include any suitable step, in some cases, they include providing a master negative mold defining an internal space shaped to form a femoral component configured to replace a distal portion of a femur, wherein the femoral component comprises at least one of: an anterior flange that is disposed at an anterior proximal end of the femoral component, and a proximal extension disposed at a proximal portion of a posterior condyle of the femoral component, the proximal extension comprising a concave articulation surface that is configured to articulate against at least one of: a tibial prosthetic component and a tibia; filling the master negative mold with a molding material to form a molded femoral component; and removing at least one of: the anterior flange, and the proximal extension from the molded femoral component to form a modified molded femoral component. Other implementations are described.
US10213823B2 Autonomous flexible manufacturing system for building a fuselage
A method and apparatus for building a fuselage assembly for an aircraft. A number of fixtures may be drive across a floor to an assembly area to form an assembly fixture. The fuselage assembly may be built on the assembly fixture.
US10213820B2 Press molding method
A press molding method of this disclosure includes: disposing a plurality of inner peripheral molding dies inside an outer shape cutting molding die having an annular cross section, the outer shape cutting molding die being configured to press-mold an identical outer shape member from a base material formed of a metal plate, the identical outer shape member having an outer shape identical to a final-shaped member, the inner peripheral molding dies being configured to press-mold all through-holes and all unevenness disposed on the final-shaped member to the base material or the identical outer shape member; and shifting all timings of press moldings to the base material and the identical outer shape member with the outer shape cutting molding die and the plurality of inner peripheral molding dies to one another.
US10213818B2 Method for preparing hot-rolled semifinished steel rolled stock for cold rolling
The invention relates to the field of pressure treatment of metals and can be used in the production of a cold-rolled strip. The problem addressed by the invention is that of being able to exclude a pickling operation in the preparation of semifinished rolled stock for cold rolling. Complete de-scaling of the surface of the semifinished rolled stock without using picking is provided by carrying out preliminary cold rolling of the semifinished rolled stock in rolling-mill rolls according to prescribed values for compression and for the ratio of compression to deformation zone length. The rolling can be carried out in one of two consecutively mounted mills.
US10213816B2 Pipeline pig with hydraulically balanced collapsible sealing elements
A pipeline pig that can traverse dual- or multiple-diameter pipes or pipelines has collapsible and expandable sealing elements that support the pig, provide a sliding (dynamic) seal with the pipe wall, and maintain the necessary pressure for driving or cleaning as the elements collapse and expand. The sealing elements each have an internal cavity sized to house a first volume of a fluid and a reservoir sized to house a second volume of the fluid. The cavity and reservoir are arranged so that a portion of the volumes of the fluid can move between each. An accumulator maintains a pressure of the first and second volumes of the fluid so that regardless of the sealing element's current size, or whether the element is transitioning between sizes, the element can maintain a sliding seal engagement with the pipe wall and perform the primary function of driving or cleaning (or both).
US10213815B1 Method of cleaning the inlet to a thruster while in operation
A method for the prevention or remediation of flooding waters in a geographic area using one or more thrusters to increase the velocity of a portion of the water in a channel draining the flooding waters away from the geographic area, mixing the portion of the accelerated waters back in to the remainder of the waters in the channel thereby increasing the average velocity of the waters in the drainage system and increasing the rate of removal of the flooding waters from the geographic area, the thrusters having the one or more inlets approximately at ninety degrees from the centerline of the thruster and cleaning the thruster inlets by reversing the flow through the thruster while the flooding waters are still passing the thruster.
US10213814B2 Adhesive roll
The invention relates to an adhesive roll comprising at least one sheet of adhesive material, the sheet comprising an adhesive and being doped with at least one optically detectable dopant.
US10213809B2 Sorting screen for sorting material and rotor body for such a sorting screen
A sorting screen for sorting material comprises a row of rotatable, driven shafts mutually spaced in a conveying direction. Each shaft extends transversally to said conveying direction and carries carrying a row of radially extending rotor bodies for intermittently urging material on the sorting screen upward and in conveying direction. The rotor bodies of each of said rows are mutually spaced in longitudinal direction of the respective shaft by spacers. Each spacer is a tubular spacer and each rotor body is provided with at least a recess or a number of projections retaining a respective end face of a respective tubular spacer.
US10213804B2 Fluid application device having a modular contact nozzle with a fluidic oscillator
A fluid application device having a contact nozzle assembly with a fluidic oscillator is provided. The fluid application device includes an applicator head and a nozzle assembly. The nozzle assembly includes a first conduit configured to receive a first fluid from the applicator head, a second conduit configured to receive a second fluid from the applicator head and an application conduit including a receptacle and first and second branches. The receptacle is fluidically connected with the first conduit and configured to receive the first fluid. The first and second branches are fluidically connected to the second conduit and receptacle and are configured to receive the second fluid. The nozzle assembly further includes an orifice fluidically connected to the application conduit and configured to discharge the first fluid for application onto a strand of material, and a guide slot extending from the orifice and configured to receive the strand of material.
US10213801B2 System and method for spray painting external walls of building
This solution is for painting the external walls of a building, and adopts a lightweight six axis robotic arm mounted on a mini-gondola hoisted by a pulley system with the controlling motor located within the mini-gondola, while another set of motor located on the pulley system at the roof-top end drives the mini-gondola to traverse laterally on a set of twin-rails on the roof-top of the building. Four vacuum suction cups mounted on the mini-gondola through linear actuator are used to secure the mini-gondola to the wall. Each linear actuator has three ultrasonic distance sensors that measure and manage the distance between the mini-gondola and the wall to be painted. Once the gondola is in position, the robotic arm will be activated to start the painting process.
US10213800B2 Spray head
A spray head includes a main body, a central shaft, a securing ring, a spout and a knob. The main body has a handle and a chamber, the chamber provided with a connecting opening allowing the central shaft to be inserted thereof. A disk body is disposed between the connecting section and the sleeve, the central shaft entering into the main body through the connecting opening, and the sleeve inserted into the chamber and engaging with the stepped edge such that the connecting section extends out of the chamber. The spout is provided with an outer shell and an inner tube. The knob has a stopper, and an end of the stopper has a screw, the screw of the knob inserted from the cone of the spout and engaging with the threaded aperture of the inner tube of the central shaft.
US10213793B2 Cyclonic separation apparatus
A cyclonic separation apparatus includes an outer wall, an inner wall and a cyclonic chamber defined between the outer wall and inner wall. A section of the surfaces of both the outer wall and the inner wall are flattened. The inner wall and the outer wall are also concentrically arranged. During use a fluid moving around the cyclonic chamber flows between a curved passage and a flattened passage of the cyclonic chamber.
US10213787B2 Dual wedge clamp angles blade cutter system
A cutter head assembly for a fiber roving chopper includes a cylindrical blade cartridge extending axially between a cartridge first end and a cartridge second end. The cylindrical blade cartridge includes a first surface that extends between the cartridge first and second ends and is angled with respect to a central axis of the cylindrical blade cartridge. A second surface extends between the cartridge first and second ends parallel to the first surface and the second surface faces the first surface. A blade body extends between the cartridge first end and the cartridge second end and is disposed between the first surface and the second surface.
US10213786B2 Paper shredder cutting assembly
A paper shredder cutting assembly having an arbor, spaced-apart cutting blades on the arbor, a rigid frame set apart from and parallel to the arbor, and braces coupling the arbor to the frame. Each resilient brace is a spacer between a pair of spaced-apart cutting blades. The braces support arbor and cutting blades. The rigid frame and the braces cooperate to strengthen, and to reduce translational motion of the arbor, while allowing rotation of the arbor. Each brace has a brace body, a brace tang extending therefrom, and a brace tab extending perpendicularly from the brace tang. Each brace tab is aligned with another along an edge of the rigid frame, the brace bodies are spacers between the cutting blades, and the brace tabs impair translational motion of the brace bodies. A paper shredder with a motor, gearing, and counterposing cutting assemblies has motion-limited resilient spacers adjacent to cutting blades.
US10213783B2 Nucleic acid extracting device
A nucleic acid extracting device includes an upper module, a lower module, and a material for capturing nucleic acid. The lower module has a sample reservoir receiving a sample, an elution reservoir receiving an elution, and a nucleic acid capturing chamber with the material disposed therein. The upper module has a sample channel that communicates with the sample reservoir, and an elution channel that communicates with the elution reservoir. The nucleic acid capturing chamber communicates with the sample channel and the elution channel. When a sample enters the nucleic acid capturing chamber via the sample channel, a nucleic acid in the sample is absorbed by the material in the nucleic acid capturing chamber, and the elution enters the nucleic acid capturing chamber, via the elution channel, to wash the nucleic acid out of the nucleic acid capturing chamber.
US10213780B2 Multivalence semiconductor photocatalytic materials
Described herein are heterogeneous materials comprising a p-type semiconductor comprising two metal oxide compounds of the same metal in two different oxidation states and an n-type semiconductor having a deeper valence band than the p-type semiconductor valence bands, wherein the semiconductor types are in ionic communication with each other. The heterogeneous materials enhance photocatalytic activity.
US10213779B2 Photocatalytic filter, method for manufacturing the same, and method for reactivating the same
The devices, systems and techniques disclosed in this patent document include photocatalytic filter devices and can be used to provide a method for manufacturing a photocatalytic filter with improved adhesion. In addition, the present disclosure of this patent document includes technology to provide a method for reactivating a photocatalytic filter. Using the disclosed techniques, even if a photocatalytic filter is contaminated, the contaminated photocatalytic filter is easily reactivated while maintaining improved adhesion.
US10213778B2 Catalytic converter and method of controlling exhaust emission
The present disclosure relates to an improved catalytic converter capable of significantly reducing emissions by reducing the activation time of a catalytic device thereby improving emissions reduction performance, and an exhaust emission emissions reduction control method using the improved catalytic converter. The improved catalytic converter includes: a housing and two or more catalyst substrates disposed inside the housing, wherein the two or more catalyst substrates are separated inside the housing along a longitudinal direction, and the two or more catalyst substrates have a different diameter and a different volume.
US10213777B2 Metal complex and supported metal complex having disiloxane as ligand, method for production therefor, and supported metal catalyst prepared by using the same
A metal complex represented by the following Formula (1): (wherein M represents palladium or platinum; L represents a ligand selected from carbon monoxide, an olefin compound, an amine compound, a phosphine compound, an N-heterocyclic carbene compound, a nitrile compound and an isocyanide compound; n represents an integer of 0 to 2 showing the number of the ligand; and each of R1 to R4 represents an organic group). The metal complex described above can be fixed on an inorganic oxide while maintaining a skeletal structure thereof to obtain a supported metal complex, and this makes it possible to allow the supported metal complex to maintain the same catalytic activity as that of the original metal complex. Also, calcining the supported metal complex obtained in the manner described above makes it possible to obtain a supported metal catalyst which is improved in catalytic activity to a greater extent than conventional supported metal catalysts.
US10213774B2 ZSM-5 catalyst
Disclosed in certain embodiments are ZSM-5 zeolite microspheres. Disclosed in certain embodiments is a method of forming ZSM-5 zeolite microspheres including: 1) shaping a mixture into microspheres where the mixture includes a silica material and of particulates selected from at least one high-density material with an absolute bulk density of at least 0.3 g/cc, ZSM-5 zeolite crystals, and combinations thereof; 2) calcining the microspheres; and 3) reacting and subsequently heating the microspheres with at least one alkali solution to form ZSM-5 zeolite in-situ on the microspheres, where the ZSM-5 zeolite microspheres contain substantially no clay or calcined clay material.
US10213773B2 Process for the conversion of oxygenates to olefins
The present invention relates to a process for converting oxygenates to olefins, comprising (1) providing a gas stream comprising one or more ethers; (2) contacting the gas stream provided in (1) with a catalyst, the catalyst comprising a support substrate and a layer applied to the substrate, the layer comprising one or more zeolites of the MFI, MEL and/or MWW structure type.
US10213769B2 Method for producing hydrocarbon dehydrogenation catalyst using sponge-type support
Disclosed are a catalyst for dehydrogenating a paraffinic hydrocarbon and a method of preparing the same, wherein the catalyst is configured such that a sponge-type alumina support having 3D meso/macro pores is directly impregnated with an active metal, thus decreasing the diffusion resistance of a material, realizing structural stability, and maximizing the distribution of the active metal in the support, thereby significantly increasing olefin conversion and selectivity. In this catalyst, the sponge-type alumina support is directly impregnated with the active metal to thus form an active metal layer inside the support having 3D meso/macro pores that are interconnected to each other.
US10213767B2 Catalyst for purifying the exhaust gases of diesel engines
The present invention relates to a catalyst that comprises a carrier body with a length L, which extends between a first end face ‘a’ and a second end face ‘b’, and differently composed, catalytically-active material zones A, B, and C arranged on the carrier body, wherein material zone A contains platinum or platinum and palladium with a weight ratio Pt:Pd of ≥1 and, starting from end face ‘a’ or starting from end face ‘b’, extends along 70 to 100% of the length L, and material zone B contains palladium or platinum and palladium and, starting from end face ‘b’, extends along a portion of the length L, and material zone C contains SCR-active material and, starting from end face ‘a’, extends along a portion of the length L, wherein material zone C is arranged above material zone A.
US10213765B2 Chromatography ligand comprising domain C from Staphylococcus aureus protein A for antibody isolation
The present invention relates to a chromatography ligand, which comprises Domain C from Staphylococcus protein A (SpA), or a functional fragment or variant thereof. The chromatography ligand presents an advantageous capability of withstanding harsh cleaning in place (CIP) conditions, and is capable of binding Fab fragments of antibodies. The ligand may be provided with a terminal coupling group, such as arginine or cysteine, to facilitate its coupling to an insoluble carrier such as beads or a membrane. The invention also relates to a process of using the ligand in isolation of antibodies, and to a purification protocol which may include washing steps and/or regeneration with alkali.
US10213764B2 Nanostructured sand, process for producing nanostructured sand, process for separating a pollutant-water mixture with the nanostructured sand and further uses
Provided is nanostructured sand, a process for producing same, a process for separating a pollutant-water mixture, and uses of the nanostructured sand.
US10213760B2 Catalytic reactors comprising distributed temperature sensors
A catalytic reactor is provided comprising a plurality of first flow channels including a catalyst for a first reaction; a plurality of second flow channels arranged alternately with the first flow channels; adjacent first and second flow channels being separated by a divider plate (13a, 13b), and a distributed temperature sensor such as an optical fiber cable (19). The distributed temperature sensor may be located within the divider plate, or within one or 10 more of the flow channels.
US10213756B2 Magnetic disc coupler
A blending appliance includes a housing with a jar receiving area defined between an upper housing and a support base. A blender jar includes a base portion and a receptacle portion, and is configured to be laterally received within the jar receiving area of the housing. A magnetic coupling system includes an upper magnetic coupler disposed in the base portion of the blender jar and a lower magnetic coupler disposed in the support base of the housing. The upper and lower magnetic couplers are magnetically coupled to one another for driving a blade assembly disposed in the receptacle portion of the blender jar. A brake mechanism is disposed on the upper magnetic coupler and is configured to stop rotation of the upper magnetic coupler when the blender jar is removed from the jar receiving area.
US10213755B2 Wellsite mixer sensing assembly and method of using same
A mixer sensing assembly of a mixer for mixing a wellsite fluid in a tank at a wellsite is provided. The mixer includes a shaft driven by a driver and a paddle operatively connectable to the shaft and rotatable therewith. The sensor assembly includes a mount operatively connectable to the shaft, a fluid interface, and a mixing sensor. The fluid interface is responsive to flow of the wellsite fluid passing thereby, and is connectable to the mount. The mixing sensor is connectable to the mount, the fluid interface, and/or the shaft to measure a strain applied to the thereto whereby fluid parameters of the wellsite fluid may be determined. The wellsite fluid may be mixed moving the components in the tank with the mixer, and measuring a strain on the mixer by detecting movement of the sensor assembly.
US10213752B2 System, method and capsules for producing sparkling drinks
A system and a method for the production and provision of CO2 gas are disclosed. A sealable chamber is equipped with heating means and when a CO2 carrier material, such as sodium bicarbonate is placed in it and heated to its decomposition temperature CO2 gas is released. The released gas is conveyed into liquid within a container and when the pressure of the gas in the container raises more and more CO2 gas is dissolved. The heating may be done by conduction mechanism, a microwave heating mechanism or by induction mechanism. The sodium bicarbonate or any other material including carbon dioxide may be disposed in powder, solid, suspension, emulsion, solution or wet powder form. It may be disposed in thin envelope case.
US10213750B2 Hydrophilically modified fluorinated membrane (I)
Disclosed are polymers suitable for hydrophilically modifying the surface of porous fluoropolymer supports, for example, a copolymer of the formula: Also disclosed are a method of preparing the polymers, a method of hydrophilically modifying porous fluoropolymer supports, hydrophilic fluoropolymer porous membranes prepared from the polymers, and a method of filtering fluids through the porous membranes.
US10213746B2 Selective interfacial mitigation of graphene defects
A method for the repair of defects in a graphene or other two-dimensional material through interfacial polymerization.
US10213745B2 Hollow fiber cartridges and components and methods of their construction
Hollow fiber cartridges and components and methods of their construction.
US10213729B2 Hydrocarbon gas decarbonation method
Method of decarbonating a hydrocarbon gas, a natural gas for example, by washing with a solvent.Said gas is contacted with an absorbent solution so as to obtain a CO2-depleted gas and a CO2-laden absorbent solution. The CO2-laden absorbent solution is then heated and expanded at a predetermined pressure and temperature so as to release a hydrocarbon-containing gaseous fraction and to obtain a hydrocarbon-depleted absorbent solution, said pressure and temperature being so selected that said gaseous fraction comprises at least 50% of the hydrocarbons contained in said CO2-laden absorbent solution and at most 35% of the CO2 contained in said CO2-laden absorbent solution. Finally, the hydrocarbon-depleted absorbent solution is thermally regenerated so as to release a CO2-rich gaseous effluent and to obtain a regenerated absorbent solution.
US10213717B2 Device for introducing a fluid medium into a container
A device for introducing fluid medium into a container, the device including a container for receiving the medium and a pipeline for introducing the medium into the interior of the container. The pipeline has a pipeline section arranged in the interior of the container having a hollow cylindrical casing that extends along a cylinder axis of the pipeline section. The casing has an opening on a lower face that faces downward for introducing the fluid medium into the interior of the container. The opening includes two first edge portions extending along the cylinder axis and two opposing arc-shaped second edge portions that connect the two first edge portions to each other. A plate-shaped impact element is fixed to the casing and arranged below the opening so that the fluid medium that flows out of the opening strikes the impact element.
US10213712B2 Liquid filter assembly
A liquid filter assembly is provided for an appliance. The liquid filter assembly may define an axial direction and a radial direction. The assembly may also include a filter medium, a housing, a pair of end caps, one or more interlocking ring, and/or a leveling tube. The filter medium may extend along the axial direction between a first end and a second end. The filter medium may define an interior passage to receive liquid passed through the filter medium. The housing may be disposed about the filter medium. The housing may define a liquid inlet opposite the first end of the filter medium.
US10213711B2 Filter assembly for removing high molecular weight hydrocarbons from liquified propane gas
Described herein are filter assemblies for removing high molecular weight organic components from liquefied petroleum gas, as well as methods for removing high molecular weight components from liquefied petroleum gases. The filter assemblies include an upstream carbon-containing filter media pack and a downstream filter media pack.
US10213710B2 Filter assembly
Filter assembly for a liquid medium comprising a two-piece filter housing having a first and a second housing part with a first and second end wall respectively, surrounded by a circumferential wall, said housing parts accommodating in the space defined between the end walls three layers of filter material, and with a spacer in-between having an open structure with upstanding ribs defining chambers there between and having two end planes which define abutment planes for two layers of filter material and with a passage crosswise to the plane thereof, and with between the second layer of filter material and the second end wall a third layer of filter material, in which all three layers of filter material are discrete layers, the space between the third layer of filter material and the second end wall, and the chambers in the spacer, being in connection to the filter outlet, and the space between the first layer of filter material and the first end wall being connected to the filter inlet.
US10213708B2 Formulations of homopolymers based on alkyl acrylates used as antifoaming agents in heavy and super-heavy crude oils
The present invention relates to the application based on alkyl acrylate homopolymers, such as antifoaming agents in crude oils with densities of 10 to 40° API. Evaluation tests in “live” crude oil, under similar gas-liquid separation equipment conditions, showed that these polymers based on alkyl acrylate are effective foaming inhibitors in heavy and super-heavy crude oils, reducing the foam between 15 and 50% faster compared to crude oil without an antifoaming agent. Some acrylics show better performance than commercial silicon-based polymers, which suppress foam 20-25% faster than the blank. The antifoaming agents of this invention, based on alkyl acrylate and totally free of silicon, is an advantageous option, to replace the silicone-based foam inhibitors currently on the market.
US10213706B2 Process and apparatus for purification of acrylic acid
A process and an apparatus for the purification of a crude acrylic acid composition containing maleic anhydride as an impurity comprising the following steps: (a) carrying out at least one dynamic melt crystallization stage (14, 14a, 14b, 14c, 14d) with the crude acrylic acid composition to prepare a first purified acrylic acid composition and a first residue containing at least 3.5% by weight maleic anhydride, (b) adding a solvent (26) which is capable of dissolving maleic anhydride to the first residue in an amount that the weight ratio of the solvent to the maleic anhydride is 0.3 or more to prepare a ratio-adjusted residue and (c) carrying out at least one further dynamic melt crystallization stage and/or at least one static melt crystallization stage (18, 18a, 18b) with the ratio-adjusted residue to prepare a second purified acrylic acid composition and a second residue.
US10213702B2 Toy racetrack with moveable loop portion
Disclosed is a toy racetrack having a toy vehicle launching section that, in a first configuration of the racetrack, launches a toy vehicle toward and through the open, central portion of a loop track section, preferably to impact a target, and in a transformed configuration of the racetrack, launches a toy vehicle through the track portion of the loop track section and preferably toward a catch tray. Two loop track sections are pivotably mounted to a tower, and target flags may be pivotably mounted to a loop section mounting block positioned at the top of the tower. Once one of the target flags is struck by a toy vehicle, an internal transformation mechanism is triggered that causes the loop track sections to pivot into a track engaging position in which the loop sections form terminal track portions for the track segments in the launching section of the racetrack.
US10213701B2 Passenger restraint for upright, straddle-type seating in an amusement park ride vehicle
A ride vehicle with upright, straddle-type passenger seating that includes a passenger restraint system. This restraint system includes a lap bar assembly and a lap bar pivotal mount element pivotally supporting the lap bar assembly within the vehicle body to pivot about a rotation axis passing through the vehicle body between the seat pan and the front end of the vehicle body. The lap bar assembly may include a lap bar along with side and front leg shields that contain a passenger's legs within the vehicle. The lap bar assembly is rotatable as a unit about the rotation axis, in a forward portion of the vehicle body, from a disengaged position to an engaged position. In the disengaged position, the leg shields are moved forward away from an access to the seat pan, and, in the engaged position, the passenger's legs are blocked from lateral and forward movement.
US10213700B2 Emergency-egress, zip-line system and method
Emergency egress systems carry multiple riders simultaneously accessing zip line catenary from higher, inaccessible, working locations to lower, safer areas. Hangers above the track line suspend trolleys to avoid weighting the catenary unduly at the high end, which might otherwise alter (reduce) clearance distances and safety of riders above a launch platform (deck). Catenary shape is controlled against approaching a launch deck by sequencing the release from the hangers of each trolley to roll along the catenary with its own rider. Autonomous braking, inter-trolley bumpers, and vertical stabilizers enable each rider to quickly occupy a seat (harness, etc.) and launch onto the track line, unconcerned with riders ahead or behind until underway. Multiple trolleys may thus load, launch, and in close proximity on a single line, regardless of the total weight of multiple riders.
US10213696B2 Adaptation of gaming applications to participants
Methods, systems, and products adapt gaming applications to participants. Should one of the participants be a minor, for example, the gaming application may adapt to scenarios that are appropriate for minors. Similarly, the gaming application may adapt to customs associated with a country of a participant.
US10213695B2 Methods and systems for processing gaming data
Methods and systems for content processing are described. In one embodiment, gaming data is received from a gaming source server. The gaming data associated with a game. A content signal is received from a signal source during presentation of programming content. The programming content is associated with the content signal and the game. A determination of whether the content signal includes the trigger is made. The device content is presented using the gaming data. The device content is in synchronization with the presentation of the programming content based on a determination that the content signal includes a trigger. Additional methods and systems are disclosed.
US10213690B2 Determining real-world effects from games
A game system in which virtual representations of real-world, physical objects may be designed or modified by game players within a virtual game universe. Real-world physical interactions of the virtual objects may be simulated by a game engine during game play within the game universe. Performance data may be collected for the virtual objects that simulates real-world performance data for corresponding physical objects. The performance data for the virtual objects may, for example, be used in evaluating performance of modifications to a physical object, or for comparing performance of two or more physical objects. Production or manufacturing decisions for respective physical objects may be made at least in part based on the performance data collected for the virtual representations of the objects.
US10213689B2 Method and system modeling social identity in digital media with dynamic group membership
A method for modeling a virtual identity in a digital media system is disclosed. A plurality of categories are defined according to identity characteristics of a virtual identity. A degree of a membership is modeled in a category for members of the category, wherein each category includes a plurality of features. Changes to membership are simulated, wherein the degree of membership includes a gradient value in a category feature over time.
US10213688B2 Social and procedural effects for computer-generated environments
A processor provides a simulated three-dimensional (3D) environment for a game or virtual reality (VR) experience, including controlling a characteristic parameter of a 3D object or character based on at least one of: an asynchronous event in a second game, feedback from multiple synchronous users of the VR experience, or on a function driven by one or variables reflecting a current state of at least one of the 3D environment, the game or the VR experience. In another aspect, a sensor coupled to an AR/VR headset detects an eye convergence distance. A processor adjusts a focus distance for a virtual camera that determines rendering of a three-dimensional (3D) object for a display device of the headset, based on at least one of the eye convergence distance or a directed focus of attention for the at least one of the VR content or the AR content.
US10213686B2 Modeling complex environments using an interconnected system of simulation layers
A method is provided for creating or evolving a virtual environment with a computer system. Steps of the method include: forming a plurality of layers of data, including a first layer and a second layer, each layer including a plurality of cells containing data corresponding to a variable; operating on the data from the cells in the first layer with a function to yield target data; distributing the target data to corresponding cells in the second layer; and altering the data in at least one of the plurality of cells in each layer according to a rule.
US10213684B2 Device and system for generating and automatically controlling a force for moving a moveable element located in real time
A device for generating and automatically controlling a displacement force of a mobile entity located in real time includes elements for generating a force of movement, the elements being controllable so as to generate a force in a plurality of different directions. The device also includes: elements for receiving a radio signal; elements for transmitting an electromagnetic signal, the electromagnetic signal being transmitted in response to an activation signal and allowing a moveable entity including the device to be located in real time; and control elements connected to the reception elements and to the elements for transmitting an electromagnetic signal. The control elements are configured to control the elements for generating at least one force of movement, in response to information for controlling a received electromagnetic signal, and for generating an activation signal, in response to synchronization information of a received radio signal.
US10213681B1 Counting and scoring device
A counting and scoring device has a housing with its interior divided into right and left chambers by a vertical partition. A wheel is vertically mounted and rotatable within each chamber of the housing using a threaded bolt and hexagonal nut. The wheels have a plurality of flat outer surfaces on which to display indicia in the form of the numerals 0 through 9 viewed through a three-sided window on each side of the top portion of the housing. Ball bearings activated by a compression spring within a tapered opening in the partition are in contact with depressions in the inside walls of the wheels below each flat surface so that as each wheel rotates a numeral is centered in a window. A hexagonal cavity within the hub portion enables the left wheel to act as a wrench to tighten the hexagonal nut when assembling the device.
US10213678B2 Detachable tracked unit for powering snowboards
Detachable propelling apparatus to be fastened to a snowboard in order to propel it uphill. Said apparatus is equipped with foldable or removable tracks, being these tracks powered by either an engine, or a motor or a turbine. The apparatus is integral with an apt adjustable attachment plate, that is directly fastenable to the feet rests (boots attachments) holes of the snowboard. The invention is completed by a rucksack for transporting tracks and batteries, with an opportune frame for protecting the back of the wearer in case of fall and a remote control, in case equipped with movement sensors. The invention is a solution for the technical problem of powering a snowboard limiting the impact of such fixture on the snowboard itself.
US10213676B2 Audio and visual/touch golf training device and training method using golf training device
A golf training device with audio and visual/touch cues for independent golf swing training in an absence of a golf instructor includes a tube having a first end and a second end and an outer surface. A hand grip is disposed at least in part about the outer surface of the tube. A sliding mass is disposed slidingly within the tube, the sliding mass including a chamfer on at least one end of the sliding mass. A ball holding rod is mechanically coupled to the second end of the tube has a ball hold rod first end and a ball hold rod second end. A ball is mechanically coupled to the second end of the ball holding rod. A club head stem extends into a club head, the club head stem is mechanically coupled to the first end of the tube to rigidly affix the club head to the tube.
US10213672B2 Computerized training punching bag
An electronic punching bag includes an elongate bag formed of resilient material, a microprocessor disposed in an interior of the electronic punching bag or at a periphery of the electronic punching bag, and a display screen that extends around more than half of the periphery of the electronic punching bag. The display screen is configured to receive signals from the microprocessor. The signals cause the display screen to display visual signals.
US10213671B2 Iprogrammable electronic sports target system
A programmable electronic sports target system. The system includes one or more target devices mounted to a goal with a net. Each of the one or more target devices has a programmable module disposed therein for controlling and operating the one or more target devices. A remote control system containing a computer and a database is connected to each programmable module to receive target sensor data from the programmable module of each of the one or more target devices for analyzing the data and for transmitting operational control data to the programmable module for operational control of the target devices having the programmable module disposed therein. Target application software within mobile communications devices receives target sensor data from the remote control device and to transmit operational control data to the remote control device.
US10213668B2 Golf club shaft
A shaft 6 includes a tip end Tp and a butt end Bt. If a shaft length is defined as Ls, a distance between the butt end Bt of the shaft and a center of gravity G of the shaft is defined as Lg, and a ratio of the distance Lg to the shaft length Ls is defined as a ratio of the center of gravity of the shaft, then the ratio of the center of gravity of the shaft is equal to or less than 47%. The shaft length Ls is equal to or less than 991 mm. If a forward flex is defined as F1 (mm) and a backward flex is defined as F2 (mm), a flex point ratio C1 of the shaft calculated by the following formula (1) is equal to or less than 39%: C1=[F2/(F1+F2)]×100]  (1).
US10213664B2 Golf club head
A golf club providing improved golf ball launch conditions is disclosed herein. The golf club includes a face component and a sole comprising an elongated recess disposed proximate the face component. The elongated recess preferably is tube shaped, and preferably has an opening with a smaller width than an innermost surface of the elongated recess. The elongated recess may be a separate piece that is permanently affixed within an opening in the sole. Some embodiments of the golf club also comprise a cover affixed to the sole and at least partially covering the opening of the elongated recess, while other embodiments comprise a filler material disposed within the elongated recess or between the elongated recess and an internal surface of the face.
US10213656B2 Golf balls having multi-layered core with thermoplastic outer layer
Multi-piece golf balls containing a multi-layered core structure are provided. The core structure includes a small, heavy inner core (center) having a relatively high specific gravity, an intermediate core layer, and a surrounding outer core layer. The layers of the core structure may have different hardness gradients. In one preferred embodiment, each core layer has a positive hardness gradient. The center of the core comprises a metal material such as copper, steel, brass, tungsten, titanium, aluminum, and alloys thereof. The intermediate core layer is preferably formed from a thermoset composition such as polybutadiene rubber, and the outer core layer is preferably formed from a thermoplastic composition such as an ethylene acid copolymer. The resulting ball has high resiliency and good spin control.
US10213646B2 System for locating a golf ball
Golf ball with an outer casing has an electronic device housed in a plastic core and includes at least one receiver, a microelectronic device for evaluating and forwarding the received signals and a transmitter and/or receiver. The transmitter or receiver can communicate with a separate electronic device worn by the user. The invention will enable a player to easily find and locate a ball that is not lying on the fairway that cannot be spotted or found with the naked eye.
US10213644B2 Elliptical trainer
The invention relates to an elliptical trainer including: a frame having a first end and a second end; a rocker-rod mechanism hingedly connected to the first end of the frame; a pedal mechanism hingedly connected to the second end of the frame through a transmission mechanism; an adjustment mechanism including an adjustment table, one end of the adjustment table being rotatably connected to the frame, the pedal mechanism being slidably connected to the adjustment table, the adjustment mechanism adjusting the position of the pedal mechanism relative to the frame; and a link the two ends of which are connected to the rocker-rod mechanism and the pedal mechanism respectively so that the rocker-rod mechanism is linked with the pedal mechanism. Since the apparatus of the invention is provided with an adjustment mechanism which is rotatably connected to the frame and the pedal mechanism is slidably connected to the adjustment mechanism, an exercise experience that the user simulates climbing by means of the pedal mechanism can be improved by changing an elevation angle of the adjustment mechanism relative to the frame. In the apparatus of the invention, a resistance adjustment mechanism is provided on a flywheel, the user can obtain more exercise experiences by increasing rotation resistance of the flywheel and a turntable.
US10213641B2 Exercise machine handle system
An exercise machine carriage system which allows for a wide range of exercises while maintaining improved balance and control for the exerciser. The exercise machine generally includes a stationary frame and a carriage adapted to slide along at least one track on the frame. The carriage may include at least one opening on its upper surface to be used by an exerciser to perform a variety of exercises. The carriage may also include, either in combination with the openings or alternatively, at least one carriage strap extending across its upper surface for use in a variety of exercises. Platforms may also be included on either end of the frame, each of the platforms including its own platform strap. By utilizing such openings and/or straps, a wide variety of exercises may be accomplished that otherwise would be difficult or impossible to perform on conventional exercise machines.
US10213639B2 Adaptive resistance exerting exercise apparatus
An exercise apparatus comprising a weight stack, a flexible elongated cable having a downstream portion that is interconnected to a user selectable number of the one or more individual bodies of weight and to a second resistance device, a manually movable actuating device interconnected to a proximal end of the cable, a downstream portion of the cable being interconnected to the one or more individual bodies of weight and to the second resistance device in an arrangement that pulls on both the one or more individual bodies of weight and the second resistance device.
US10213637B1 Wearable and detachable exercise accessory
A highly portable exercise device utilizing resistance bands is provided. The exercise device includes two ends, each end with a gripping component and latching mechanism. The latching mechanism comprising two magnets, wherein each magnet is secured to opposing ends of the device. A user can thereby hold one end of the exercise device in one hand and secure the other end of the device in either the other hand or against a surface. The user can move his or her body to create tension in the exercise device allowing the user to perform a plurality of different exercises by applying a force to intended muscles.
US10213636B1 Fluid control valve
A thermally responsive fluid control valve includes a thermally responsive actuating assembly and a body having an inlet, at least one outlet, and a valve seat formed internally of the inlet. An axially translating sealing assembly is supported in a seated position against the valve seat by the thermally responsive actuating assembly and the sealing assembly has an unseated position upon operation of the actuating assembly. The sealing assembly includes a sealing member having an impact surface for redirecting fluid from the inlet to the at least one outlet and a rod member with an outer surface in a surface engagement with the opening of a cover plate and/or the actuating assembly to orient the sealing member such that the impact surface directs fluid flow to the outlets.
US10213634B1 Fire barrier blanket
A fire resistant system comprising a flexible blanket sized to be deployable on or over an edifice, or part thereof, the blanket being flame retardant and heat resistant, the blanket consisting of aromatic polyamide (aramid) fibers defining a knit yarn fabric, the blanket fabric defining distributed vent openings of small size to freely pass air from one side of the blanket to the other, and away from elongated edifice associated objects such as hot embers, the blanket having edges configured to be pulled for distributing the blanket over the edifice.
US10213632B2 Safety anchor
The safety anchor includes a base, which is fixable to a roof structure; an absorber, which is attached to the base; and a housing, which houses the absorber. A clamping member is provided within the housing for clamping the housing against the base.
US10213631B2 Lineman harness adapter system
A lineman safety harness adapter system for use in association with a harness, having: a first harness adapter having a first strap having a first top end and a first bottom end loop configured to receive a first locking element at a first bottom end, a second strap having a second top end and a second bottom end loop configured to receive a second locking element at a second bottom end, a third strap having a third top end and a third bottom end loop configured to receive a third locking element at a third bottom end; the first strap, the second strap, and the third strap meeting at the first top end, the second top end, and the third top end into a first top loop configured to receive a fourth locking element.
US10213629B2 End of service life indicator for a respirator
Systems, methods, and devices for an end of service life indicator for a respirator are described herein. For example, a device can include a cartridge containing a filter material and an insert extending through at least a portion of the filter material having a first path with a first opening to provide a sample of air that is representative of a saturation of the filter material and a second path with a second opening configured to provide a filtered sample of the air throughout a service life of the cartridge.
US10213626B2 Treatment delivery control system and method of operation thereof
The invention relates to a method and apparatus for control of a charged particle cancer therapy system. A treatment delivery control system is used to directly control multiple subsystems of the cancer therapy system without direct communication between selected subsystems, which enhances safety, simplifies quality assurance and quality control, and facilitates programming. For example, the treatment delivery control system directly controls one or more of: an imaging system, a positioning system, an injection system, a radio-frequency quadrupole system, a ring accelerator or synchrotron, an extraction system, a beam line, an irradiation nozzle, a gantry, a display system, a targeting system, and a verification system. Generally, the control system integrates subsystems and/or integrates output of one or more of the above described cancer therapy system elements with inputs of one or more of the above described cancer therapy system elements.
US10213625B2 Proton irradiation using spot scanning
In one embodiment of the invention, a method for irradiating a target is disclosed. A proton beam is generated using a cyclotron. A first information is provided to an energy selection system. An energy level for the protons is selected using an energy selection system based on the first information. The first information comprises a depth of said target. The proton beam is routed from the cyclotron through a beam transfer line to a scanning system. A second information is provided to the scanning system. The second information comprises a pair of transversal coordinates. The proton beam is guided to a location on the target determined by the second information using a magnet structure. The target is irradiated with the protons.
US10213621B2 Trajectory optimization in radiotherapy using sectioning
A radiation therapy treatment method includes providing a patient model, dosimetric constraints, delivery motion constraints, and delivery coordinate space of a radiation delivery device, where the delivery coordinate space is represented as a mesh with vertices connected by edges, where the vertices correspond to directions of a beam eye view (BEV) of the radiation delivery device, where each BEV has corresponding area elements resulting from beam collimation. BEV region connectivity manifolds are constructed from the patient model, the dosimetric constraints, the delivery coordinate space, and existing beam trajectories, wherein each of the BEV region connectivity manifolds represents connections between contiguous 2D target regions, where each of the 2D target regions is defined at each of the vertices of the delivery coordinate space. Beam trajectories are selected based on region connectedness information in the BEV region connectivity manifolds, the dosimetric constraints, the delivery motion constraints, and the existing beam trajectories. Radiation is delivered using the radiation delivery device in accordance with the beam trajectories.
US10213619B2 Method and apparatus for determining circadian input
A method and apparatus for determining the circadian input of a light source includes selecting a circadian input to be measured based on an action spectrum corresponding to a wavelength sensitivity of photoreceptors for a circadian regulation system, where the circadian input is configured to stimulate a retinaldehyde photopigment, and for measuring spectral intensity across the action spectrum to determine the circadian input of the light source.
US10213617B2 System and method for optogenetic therapy
Configurations are described for utilizing light-activated proteins within cell membranes and subcellular regions to assist with medical treatment paradigms, such as hypertension treatment via anatomically specific and temporally precise modulation of renal plexus activity. The invention provides for proteins, nucleic acids, vectors and methods for genetically targeted expression of light-sensitive proteins to specific cells or defined cell populations. In particular the invention provides systems, devices, and methods for millisecond-timescale temporal control of certain cell activities using moderate light intensities, such as the generation or inhibition of electrical spikes in nerve cells and other excitable cells.
US10213613B2 System and method for using diagnostic pulses in connection with defibrillation therapy
An external defibrillator system is disclosed that generates and applies a diagnostic signal to the patient in conjunction with defibrillation therapy. The diagnostic signal is designed to elicit a physiologic response from the patient's heart, namely, mechanical cardiac response and electrical cardiac response, electrical cardiac response only, or no cardiac response. Depending upon the type of cardiac response detected, the system selects an appropriate resuscitation protocol that considers the likely responsiveness of the patient to defibrillation therapy. In one practical embodiment, a stimulus signal is applied to patients that show mechanical and electrical capture in response to the diagnostic signal. The stimulus signal maintains the mechanical capture (and, therefore, perfusion) for a period of time prior to the delivery of a defibrillation pulse.
US10213612B2 Visual and aural user interface for an automated external defibrillator
A method for operating a defibrillator including an aural output device includes causing the output device to deliver a first verbal instruction which includes a prompt to call an emergency response system; determining if the user elects to have the defibrillator continue on to a second instruction; and if it is determined that the user elects to have the defibrillator continue on to the next instruction, causing the defibrillator to deliver the second verbal instruction. In an exemplary embodiment, the step of determining if the user elects to continue on to the second instruction includes the step of determining if the user has performed an action upon the defibrillator.
US10213609B2 Mobile applications and methods for conveying performance information of a cardiac pacemaker
Devices, systems, and methods are disclosed for relaying information from a cardiac pacemaker to an external device. Logic on the pacemaker modulates a heartbeat clock of the pacemaker to encode information onto a blood pressure sequence by adding or subtracting a small subinterval to or from a pulse repetition interval of the pacemaker. A muscle stimulator beats the heart according to the modulated sequence. A monitoring device external to the body monitors the blood pressure to retrieve the encoded information, or message. The encoded information is then decoded to determine the information in the message. This information may concern the pacemaker as well as other devices within the body that communicate with the pacemaker such as blood monitors, etc. Since the message is conveyed via simple modulation of the heart beat intervals, no separate transmitter is required in the pacemaker which would otherwise increase cost and decrease battery life.
US10213608B2 Neurostimulation system with flexible patterning and waveforms
A neurostimulation system configured for providing neurostimulation therapy to a patient. A user customizes a pulse pattern on a pulse-by-pulse basis. Electrical stimulation energy is delivered to at least one electrode in accordance with the customized pulse pattern.
US10213607B2 User interface with view finder for localizing anatomical region
An external control device for use with a medical component implanted within a patient. The device comprises a user interface configured for receiving user input, displaying a first graphical representation of the medical component in the context of a global graphical representation of an anatomical region of the patient, displaying a view finder defining a portion of the global graphical representation, and displaying a second graphical representation of the medical component in the context of a local graphical representation of the portion of the anatomical region portion. The external control device further comprises control circuitry configured for, in response to the input from the user, modifying the displayed view finder to spatially define a different portion of the global graphical representation, such that the second graphical representation of the medical component is displayed in the context of a local graphical representation of the different portion of the anatomical region.
US10213605B2 Systems and methods for spinal cord stimulation
Optimizing temporal pulse patterns for stimulation delivery to a subject includes: generating a first generation pulse pattern; delivering stimulation according to the first generation pattern to a subject; measuring efficacy, efficiency and side-effect parameters affected by the delivered stimulation; determining a fitness of the first generation pattern using the measured parameters; generating a second generation pattern using the first generation pattern according to the determined fitness of the first generation temporal pattern; and delivering stimulation according to the second generation pattern. Iterative further optimization may include crossing any particular generation temporal pulse pattern with at least one other temporal pulse pattern to generate offspring patterns for further use and optimization. Immigrant random patterns may be added, and offspring patterns may receive point mutations. Optimization may be conducted using a computational model prior to treatment of a human subject and further optimization may occur using feedback from the subject.
US10213602B2 Treatment of headaches by electrical stimulation
Systems and methods are described, including a system for electrostimulation. The system includes a patch (22), including a plurality of electrodes (24a, 24b), and a mobile device (28). A processor (30) of the mobile device is configured to receive an input from a subject (20) that indicates that the subject is experiencing a headache, and, in response to the input, while the patch is coupled to the subject, wirelessly communicate a control signal that causes the electrodes to stimulate the subject. Other embodiments are also described.
US10213601B2 Non-invasive vagus nerve stimulation devices and methods to treat or avert atrial fibrillation
Energy is transmitted noninvasively to a patient using electrode-based stimulation devices or magnetic stimulation devices that are designed to non-invasively stimulate nerves selectively. The devices produce impulses that are used to treat atrial fibrillation, by stimulating a vagus nerve of a patient. The devices are also used to forecast the imminent onset of atrial fibrillation and then avert it by stimulating a vagus nerve.
US10213599B2 Wireless tissue stimulation devices
In one aspect, wireless gastrointestinal stimulations are described herein. In some embodiments, a system described herein comprises at least one transmitter and at least one stimulation device. The transmitter can include a signal generator operable to generate an electromagnetic signal, a first antenna operable to broadcast the electromagnetic signal, and an energy source. The at least one stimulation device is operable to deliver a pattern of electrical pulses to a gastrointestinal tissue comprising a muscle, and the stimulation device includes a circuit board having a circumference, at least one second antenna wrapped around the circumference of the circuit board, the at least one second antenna being configured to receive the electromagnetic signal and to generate an electrical current from the electromagnetic signal, and at least one electrode operable to deliver the electrical current to the muscle.
US10213591B2 Plug-in connector for medical tubes
A second part extending around a first part in a plugged-together state. The second part has snap-in element with an inwardly protruding projection for meshing with a complementary recess on an outer surface of the first part to hold the second part fixed in the axial direction on the first part. Both parts have a central passage opening. One part has an end area expanding towards the outlet opening in a connection area, and the other part is connected to an elastic section, arranged in its interior. The front end of the elastic section is pressed into contact with the expanded end area of the opposite part. The projection of the snap-in element maintains the first and second parts meshed together, so that the elastic section exerts a sealing function due to the pressure on the expanding end area.
US10213589B2 Carrier assembly with caps for medical connectors
An assembly for mounting medical connector caps includes a carrier formed from a sheet of material and having an array of holes. The assembly also includes a plurality of medical connector caps. Each cap is inserted into one of the holes of the array. The assembly also includes a plurality of sealing tabs. The tabs may be retained on the carrier by friction fit into the holes of the carrier. The carrier may also include a mounting hole to hang on a pole of an IV line.
US10213578B2 Catheter assembly
A catheter assembly includes an outer catheter and an inner catheter. The inner catheter has an accommodation unit which can be positioned on a farther distal side than an outer catheter body in a state where an inner catheter body is inserted into the outer catheter body, extends in a proximal direction from the inner catheter body, and can accommodate an outer catheter distal portion so as to surround an outer circumference thereof in a state where the outer catheter distal portion formed at a distal end of the outer catheter body is reduced in diameter. The outer catheter distal portion can be separated from the accommodation unit and can expand in diameter by moving the inner catheter body in a distal end direction relatively with respect to the outer catheter body from a state of being accommodated in the accommodation unit.
US10213570B2 Patient interface device with auto-adjusting cushion
A patient interface device includes a frame member and a cushion having a main body, a sealing portion, and first and second posts extending from the main body. The frame member defines a first orifice and a second orifice. The first post of the cushion is rotateably received within the first orifice and the second post is rotateably received within the second orifice in a manner that permits the cushion to rotate relative to the frame member.
US10213565B2 Respiratory physiotherapy device
A device for providing positive expiratory pressure therapy to a patient wherein exhaled air is at a comparatively higher pressure than atmospheric pressure, said device including a container to hold liquid, an air inlet means to allow entry of air into the container and an air outlet to allow air to vent from the container. The air inlet means includes a conduit to discharge the exhaled air. The conduit is fixed in position so that the exhaled air is discharged at or substantially adjacent the base of the container. In use liquid is introduced into the container to a predetermined level and the bottom of the conduit is below the predetermined level of liquid to provide a desired level of positive pressure and the air outlet is above the predetermined level of liquid.
US10213560B2 Injection device
An injection device includes a housing, a dose setting member being operable in a first direction to set a desired dose to be dispensed, and a piston rod being adapted to cooperate with a piston so as to cause a set dose to be injected from a cartridge. Further, a first part and a second part of the injection device are provided, which are adapted to perform a relative rotational movement with respect to each other during dispensing of a dose, and which are adapted to provide a non-visual feedback signal to a user only at the end of dispensing of a set dose. The dose setting member is further operable in a second direction which is opposite to the first direction to cancel a set dose. A third part is movable between a dose setting or cancelling position and a dose dispensing position relative to the first part and/or the second part, which third part contacts the first part and/or the second part in its dose setting or cancelling position or in its dose dispensing position.
US10213555B1 Syringe having a mechanically operated mechanism for injecting precise volumes of a solution
A syringe having a mechanical ejection mechanism. The ejection mechanism includes an actuator and a rotational gear. The actuator has a retractable pawl configured to engage the gear when the actuator is displaced from a non-depressed position into a depressed position. Displacement of the actuator causes the gear to rotate by a predetermined angle. The rotation of the gear is translated into linear displacement of the plunger within the barrel, thereby ejecting a predetermined amount of solution from the barrel.
US10213553B2 Lever and gear force multiplier medication delivery system for high pressure injection system
A method of delivering high pressure medication injections, the method comprising storing a medicament in a cartridge, engaging a lever gear in a lever assembly to a rack, rotating a lever arm in said lever assembly that is connected to said lever gear, moving said rack to move a stopper through said cartridge upon rotation of said lever arm, expelling a medicament dose from said cartridge via movement of said stopper, and injecting said medicament dose through a needle that communicates with said cartridge.
US10213546B2 Devices and methods for delivering a beneficial agent to a user
A device for delivering a beneficial agent is provided and generally includes a cassette, a pump, and a delivery tube. The pump includes a pump housing containing a pump assembly having a fluid drive component. The pump housing has a receiving region disposed proximate the fluid drive component and further includes a rear closure portion. The rear closure portion includes a membrane disposed between the receiving region and the fluid drive component. The cassette includes a cassette housing, which has a cassette body region defining a fluid reservoir chamber therein. The cassette further includes a cassette base region having a boundary configured to be received by the receiving region.
US10213545B2 Body-wall-contact-type water tank and in-cavity fluid perfusion system
A body-wall-contact-type water tank (12) is equipped with: a water-tank body for storing a fluid to be supplied into a body cavity, and positioned so as to contact a body wall (120); a through-hole which conveys the fluid stored in the water-tank body into the body cavity via an incision formed in the body wall (120), and which is formed in the bottom section of the water-tank body; and a connecting means for connecting, in a fluid-tight manner, the water-tank body to the body wall (120) and/or to a retractor (110) attached to the incision.
US10213544B2 Methods for treating a suspension of mononuclear cells to facilitate extracorporeal photopheresis
A method for performing a photopheresis procedure is provided comprising collecting MNCs in a suspension comprising RBCs and plasma and lysing the red blood cells in the solution, preferably by combining the suspension with a solution to cause lysis. In one example, the solution for causing lysis of the red blood cells comprises ammonium chloride, and the suspension including the ammonium chloride is incubated to cause lysing. After lysing, the suspension may be washed to remove plasma and hemoglobin freed by the lysis of the red blood cells, and an ultraviolet light activated substance is added to the suspension. The suspension is then irradiated with ultraviolet light.
US10213538B2 Implanted device with wireless energy transfer and external alignment feature
An implant device includes a housing and an energy receiving element disposed in the housing. The energy receiving element is configured to be electrically connected to an energy-consuming device. The implant device is configured to be mounted within a body of a human or non-human animal. The housing includes a feature configured to be accessible through skin of the animal and to receive a corresponding mating member of an external charger including an energy transmitting element. The energy receiving element is configured to receive energy wirelessly from the energy transmitting element when the external charger is mated with the housing.
US10213537B2 Ventricular assist devices and integrated sensors thereof
A ventricular assist device for intraventricular placement inside a heart of a mammalian subject includes a pump including a housing having an inlet end, an inlet at the inlet end, and an outlet. The pump further includes a moveable element disposed in the pump housing for pumping blood from the inlet to the outlet. A base member is included as well as a spacer member connected to the pump housing and the base member. The base member is positioned a distance from the inlet end of the pump housing to define a gap therebetween. One or more sensor elements are mounted to at least one from the group consisting of the base member and the housing, the one or more sensor elements being configured to measure one or more blood parameters prevailing within the gap during operation of the pump.
US10213533B2 Medical tools with aspiration tips suitable for cataract surgeries and related methods
Devices and methods for cataract surgery include a tip with reciprocating door to chop, fragment or reduce size of large nuclear lens fragments and/or cortex fragments in a capsule bag to facilitate aspiration.
US10213532B2 Portable hand pump for evacuation of fluids
A manually operable pump for the effective removal of fluids to include blood, blood clots, fluid, and air from a body cavity of a subject is provided. The manually operable pump is adapted to be connect to a range of fluid conduits and is equipped with one-way valves that effectively permit flow of fluid through the pump in only one direction. The sensitivity of the one-way valves is such that when properly positioned, fluid can flow through the valves and out of the pump without manual compression of the pump and with the aid of gravity power alone.
US10213531B2 Coating of a vascular endoprosthesis
The invention concerns a method for coating a vascular endoprosthesis, wherein the vascular endoprosthesis is at least partially wetted with a first solution of an active ingredient and the areas of the vascular endoprosthesis at least partially wetted with the first solution of the active ingredient are at least partially wetted with a liquid containing water and/or at least an alcohol. The additional wetting with a liquid containing water/alcohol imparts a different consistency to the active ingredient layer, specifically making it is less transparent and lacquer-like and more chalklike and opaque. It has been found that such an active ingredient layer provides better transfer of the active ingredient to the blood vessels in which the vascular endoprosthesis is implanted.
US10213530B2 Polymer film and antiadhesive material using the same
A polymer film can be adjusted to movement or a fine uneven surface of a living body and has excellent ability to adhere to a biological tissue. The polymer film includes a block copolymer having a structure in which branched polyalkylene glycol and polyhydroxyalkanoic acid are bound to each other, wherein the polymer film has a film thickness of 10 to 1000 nm. The branched polyalkylene glycol has at least three terminal hydroxyl groups per molecule, the mass percentage of the branched polyalkylene glycol relative to the total mass of the block copolymer is 1% to 30%, and a value obtained by dividing the average molecular weight of polyhydroxyalkanoic acid in the block copolymer by X that is the number of terminal hydroxyl groups present per a single molecule of the branched polyalkylene glycol is 10000 to 30000.
US10213528B2 Delivery of hydrophobic active agent particles
Embodiments of the invention include drug delivery coatings and devices including the same. In an embodiment, the invention includes a drug delivery coating including a polymeric layer. The polymeric layer can include a hydrophilic outer surface. The coating can also include a matrix contacting the hydrophilic outer surface. The matrix can include a particulate hydrophobic therapeutic agent and a cationic agent. The polymeric layer can further include a hydrophilic polymer having pendent photoreactive groups and a photo-crosslinker including two aryl ketone functionalities. Other embodiments are also included herein.
US10213526B2 Methods for preparation of a terminally sterilized hydrogel derived from extracellular matrix
Provided are methods for preparing sterilized, gelled, solubilized extracellular matrix (ECM) compositions useful as cell growth substrates. Also provided are compositions prepared according to the methods as well as uses for the compositions. In one embodiment a device, such as a prosthesis, is provided which comprises an inorganic matrix into which the gelled, solubilized ECM is dispersed to facilitate in-growth of cells into the ECM and thus adaptation and/or attachment of the device to a patient.
US10213524B2 Coating comprising strontium for body implants
The present invention relates to a coating, a substrate, a method for coating a body and a method for producing the body substrate, such as a dental or a bone implant. The coating has a high degree of mechanical stability and comprises elements, such as Sr based compounds, which optimize the tissue response to the implanted body thus stimulating healing, bone or tissue growth in the vicinity of the implant. An implant coated with this coating has the ability of sustained release of strontium in a non-toxic concentration of strontium in the vicinity of the implant.
US10213515B2 Glycopeptide for contrast agent targeting cancer cells and contrast agent kit containing the same
The present disclosure relates to a glycopeptide targeting cancer cells and a contrast agent kit containing the same. The glycopeptide is one wherein an azide reporting monosaccharide is bound to a substrate peptide. As the substrate peptide is specifically cleaved by cathepsin B in cancer cells, an azide reporting monosaccharide is expressed onto the cell surface via metabolic glycoengineering, thereby providing a target for action as a contrast agent. Accordingly, because the azide is exposed to the cell surface only by cathepsin B, as it is specifically expressed in cancer cells, in particular in metastatic cancer cells, while it is limitedly expressed in normal cells and is hardly excreted out the cells, the cancer cells can be selectively imaged by an azide-specific contrast agent.
US10213514B2 Functionalizing nanofibres
Methods for functionalizing the surface of nanofiber substrates, including electrospun fibers and non-woven or woven mats of fibers are described. Functionalized nanofiber substrates presenting biologically active moieties such as biotin and saccharides are described.
US10213511B2 Thermoreversible compositions for administration of therapeutic agents
The present invention relates to compositions and methods of inducing the self-renewal of stem/progenitor supporting cells, including inducing the stem/progenitor cells to proliferate while maintaining, in the daughter cells, the capacity to differentiate into hair cells.
US10213506B2 Targeting immunotherapy for amyloidosis
Disclosed are methods and compositions for targeting antibodies to amyloid deposits. For example, amyloid-reactive peptides that bind amyloid deposits are administered to a subject. Antibodies to the amyloid-reactive peptides are then administered to the subject. Upon administration of the antibodies, the amyloid-reactive peptides bind the antibodies and thus pre-target the antibodies to the amyloid deposits. In other examples, an amyloid-reactive fusion peptide contains an epitope of a known antibody. When the fusion peptide is administered to a subject, the fusion peptide binds amyloids in the subject. Administration to the subject of the known antibody that binds the epitope of the fusion peptide then targets the antibody to the amyloid deposit to which the fusion peptide is bound.
US10213502B2 Vaccine for falciparum malaria
The invention provides compositions and methods for preventing or reducing the severity of malaria.
US10213497B2 Vaccine
The disclosure relates to polypeptides and pharmaceutical compositions comprising polypeptides that find use in the prevention or treatment of cancer, in particular breast cancer, ovarian cancer and colorectal cancer. The disclosure also relates to methods of inducing a cytotoxic T cell response in a subject or treating cancer by administering pharmaceutical compositions comprising the peptides, and companion diagnostic methods of identifying subjects for treatment. The peptides comprise T cell epitopes that are immunogenic in a high percentage of patients.
US10213495B2 Methods of treating allergies and autoimmune diseases with homogenate of axenic C. elegans
Methods of using axenic C. elegans homogenate for treating allergies or an autoimmune disease are disclosed. Also disclosed is a composition comprising a homogenate of C. elegans, wherein the homogenate is obtained from C. elegans cultured in axenic media, for use in treating an allergy or autoimmune disease.
US10213493B2 Protein to promote blood vessel growth and uses thereof
A method for stimulating angiogenesis in a tissue of a mammal comprising contacting tissue with a protein substantially similar to pyruvate kinase M2.
US10213486B2 Formulations of diluted amino acid segments and methods for making same
A formulation of a diluted amino acid fragment is prepared by mixing an amino acid fragment and a diluting agent to form a mixture. The mixture is serially diluted to produce a diluted formulation. The amino acid fragment includes a peptide sequence that is the same as a portion of a longer peptide sequence found in a naturally occurring material. A homeopathic remedy can be prepared using the formulation.
US10213483B2 Oligopeptidic compounds and uses thereof
Disclosed is A method of treatment of a disorder or condition where it is desirable to inhibit the growth of cells, or a method of treatment which involves cytostatic therapy by administering an oligopeptidic compound to a subject in need thereof. The oligopeptidic compound is capable of interacting with proliferating cell nuclear antigen (PCNA) The compound comprises a PCNA interacting motif which is: which is: [K/R]-[F/Y/W]-[L/I/V/A/M]-[L/I/V/A/M]-[K/R] (SEQ ID NO. 28).The oligopeptidic compound has 9-70 subunits and at least one signal sequence. The signal sequence is a nuclear localization signal sequence and/or a cell penetrating signal sequence. In the compound a PCNA interacting motif is N-terminal to a signal sequence.
US10213482B2 Methods of treating chronic inflammatory diseases
The present invention relates to a peptide, or a salt thereof, comprising or consisting of the amino acid sequence IHMVYSKRSGKPRGYAFIEY, comprising one or more post-translational modifications, for the treatment, prevention or amelioration of a hyper autophagy-related autoimmune disease or disorder.
US10213477B2 Peptidomimetic macrocycles
Provided herein are peptidomimetic macrocycles containing amino acid sequences with at least two modified amino acids that form an intramolecular cross-link that can help to stabilize a secondary structure of the amino acid sequence. Suitable sequences for stabilization include those with homology to the p53 protein. These sequences can bind to the MDM2 and/or MDMX proteins. Also provided herein are methods of using such macrocycles for the treatment of diseases and disorders, such as cancers or other disorders characterized by a low level or low activity of a p53 protein or high level of activity of a MDM2 and/or MDMX protein.
US10213476B2 Compstatin analogs with improved potency and pharmacokinetic properties
Compounds comprising peptides capable of binding C3 protein and inhibiting complement activation are disclosed. The compounds include a modified compstatin peptide or analog thereof, comprising an added N-terminal component that improves (1) the binding affinity of the peptide to C3, C3b or C3c and/or (2) the plasma stability and/or plasma residence time of the peptide, as compared with an unmodified compstatin peptide under equivalent conditions. Methods of improving the C3 binding of compstatin or compstatin analogs are also disclosed, as well as methods of designing compstatin analogs with improved C3 binding.
US10213473B2 Marine peptides and nucleotides
Provided herein is a method of reducing postprandial concentrations of glucose in a subject's blood comprising administering to the subject, prior to or during a meal, an effective amount of a combination of a marine peptide and a fish nucleotide, sufficient to reduce the glucose concentration in the subject's blood. Further provided herein is a method of reducing postprandial concentration of ghrelin in a subject's blood, comprising administering to the subject, prior to or during a meal, an effective amount of a combination of a marine peptide and a fish nucleotide sufficient to increase the blood component wherein the combination is administered to the subject.
US10213471B1 Method for making a pain reliever oil
A pain reliever oil made of a mixture of dried flower oil extract, carrier oils, magnesium oil, spice oil extract, essential oils, and pepper oil extract. The method of preparing the pain reliever oil includes marinating the dried flowers, the spices and the peppers in oil for specific times and under specific conditions. It is applied topically to relieve pain.
US10213465B1 Method and system for repairing damaged tissue using nucleated plasma particles (Nuc-P2s) and mesodermal stem cells (MesoSCs)
The current invention is a method and system for optimally isolating adult derived stem cells from whole blood and reintroducing the adult derived stem cells into a subject at specific target areas having damaged tissue to be repaired.
US10213463B2 Compositions for biological systems and methods for preparing and using the same
A method for performing a therapy in a subject includes providing a composition including a solution having a first volume and including a low pH fluid base including dextrose, and albumin, wherein the concentration of albumin in the solution is between about 10 mg/ml and about 150 mg/ml, and implanting within, near, or adjacent tissue of the subject an effective amount of the composition.
US10213462B2 Galectin-3 plasmapheresis therapy
The invention is directed to the removal of serum gal-3 from circulation by plasmapheresis, comprising at least in part donor apheresis, using gal-3 binding agents in either a fixed bed, or in a form easily removed, such as by being complexed with magnetic particles. This method, on its own, brings a sharp reduction and relief from the inflammation and fibroses that can be induced by circulating gal-3. The process may be combined with the administration of gal-3 binding agents, such as modified citrus pectin, to further lower unbound gal-3 levels, to the point where gal-3 in the tissues may be addressed. This method may also be combined with removal of TNF receptors to provide an effective treatment for cancer.
US10213461B2 Combined autologous biologic and cold therapy treatment of skin injuries
This disclosure describes a combined autologous biologic and cold therapy treatment for treating various skin injuries. The treatment may include applying autologous blood components, including but not limited to platelet rich plasma, to a skin injury in a manner that influences the healing process. A tray assembly for freezing autologous blood components includes a tray body and a plurality of compartments formed in the tray body. Each of the plurality of compartments is configured to receive an individual dose of an autologous blood component.
US10213459B2 Compositions of functional mitochondria and uses thereof
Mitochondrial compositions and therapeutic methods of using same. Compositions of partially purified functional mitochondria and methods of using the compositions to treat conditions which benefit from increased mitochondrial function by administering the compositions to a subject in need thereof.
US10213458B2 Differential tumor cell cytotoxicity via contact with coated cerium oxide nanoparticles
Differential surface-charge-dependent localization of nanoceria in normal cells and cancer cells plays a critical role in the toxicity profile of a nanoceria particle. Engineered surface-coated cerium oxide nanoparticles with different surface charges that are positive, negative and neutral provide therapeutic results for normal and cancer cell lines. Results show that nanoceria with a positive or neutral charge enters most of the cell lines studied, while nanoceria with a negative charge internalizes mostly in the cancer cell lines. Moreover, upon entry into the cells, nanoceria is localized to different cell compartments (e.g. cytoplasm and lysosomes) depending on the nanoparticle surface charge. The internalization and subcellular localization of nanoceria plays a key role in the nanoparticle cytotoxicity profile, exhibiting significant toxicity when they localize in the lysosomes of the cancer cell lines. In contrast, minimal toxicity is observed when they localize into the cytoplasm or do not enter the cells.
US10213453B2 Control release of fat soluble antioxidants from an oral formulation and method
Oral formulation of particles made of an agglomeration of a plurality of seed granules or a single seed granule both surrounded by three layers and an outer gel coating. The seed granules are made of calcium carbonate with microscopic fissures. Disposed inside the fissures and in the interstitial spaces of the agglomerate seed granules are microscopic particles of alkali metal salts and other ions. Coating the agglomerate or single seed granules is an alkaline-resistant first layer made of microcrystalline cellulose and croscarmellose sodium that binds and protects the surrounding second layer. Surrounding the first layer is a second layer comprising a mixture of a flavonoid and polysaccharide or polypeptide binder or polymer gel. Surrounding the second layer is a third layer made of alkaline earth metal salt particles holding alkali metal hydroxide ions within a polysaccharide or polymer gel. Surrounding the third layer is at least one outer gel layer. The fourth and third layers dissolve in a low pH environment and release the fat soluble antioxidant and ions in the seed granule fissures.
US10213443B2 Tetracycline topical formulations, preparation and uses thereof in treating an ocular condition
The invention relates to a topical suspension formulation that includes a tetracycline, a liquid medium and a polymeric gelling agent. The tetracycline may be in the form of its pharmaceutically acceptable salts, hydrates, or polymorphs and is in a suspended form within the formulation. The liquid medium is selected such that it does not dissolve or substantially minimally dissolves the tetracycline. The gelling agent is a polymeric hydrocarbon gelling agent. Preferably, the tetracycline has a particle size of less than or equal to about 20 microns.
US10213440B2 Oral transmucosal pharmaceutical compositions including testosterone and an aromatase inhibitor
Formulations for oral transmucosal compositions including a synergistic combination of low doses of testosterone with an aromatase inhibitor (AI) that are combined with transmucosal absorption enhancers are disclosed. Oral transmucosal compositions can be for fast release or slow release, and can be administered to increase bloodstream testosterone levels and thereby reduce symptoms of testosterone deficiency. Oral transmucosal compositions include liquid dosage forms, solid dosage forms, and chewing gums. Further dosage forms include mucoadhesive thin strips, thin films, tablets, patches, and tapes, among others. Other dosage forms are: mucoadhesive liquids such as gel-forming liquids; gel-forming semisolids; and gel-forming powders, among other dosage forms that exhibit mucoadhesive properties, and provide oral transmucosal delivery of testosterone and AI. Oral transmucosal compositions will deliver testosterone and AI directly into the patient's bloodstream, and provide high bioavailability of testosterone and AI; therefore, the required doses are lower.
US10213439B2 Therapeutic and method of use
The present invention is a compound comprising an anti-inflammatory drug component consisting preferably of at least one of an NSAID portion and a cannabis portion and at least one of a progestin component and a progesterone component. The compound may take for instance the form of a pill or pellet (for oral internal use or for subdermal implantation), an injectable solution, or a suppository. The compound is intended for use in treating subjects having or being at increased risk—especially genetically determined risk—of developing endometriosis. The compound may also be used for treating other disorders or as a contraceptive.
US10213438B2 Alkaloid compounds for treating depression, substance addictions, and indications associated with chronic inflammation
Alkaloid compounds described herein are useful for treating disorders associated with monoamine oxidase (MAO) activity, such as depression, pain, smoking cessation, and substance addictions, and/or for treating disorders associated with chronic or low-level inflammation. In some examples, compounds are effective for treating cancers, autoimmune disorders, and other disorders associated with inducible nitric oxide synthase (iNOS).
US10213437B2 Pharmaceutical preparation for masked taste oral administration, containing clomipramine
The present invention relates to a pharmaceutical preparation for oral administration comprising, as an active ingredient, clomipramine or a pharmaceutically acceptable salt thereof; and a cation exchange resin and an anion polymer as a taste masking agent, wherein the pharmaceutical preparation can be orally administered even while comprising a pharmaceutically effective amount of clomipramine because the unique tastes of clomipramine, particularly, all of the bitter taste, spicy taste and burning taste are effectively masked, and thus the convenience of drug intake and portability is improved, and a method for manufacturing thereof.
US10213436B2 Methods of treating cancer using aurora kinase inhibitors
Disclosed are methods for the treatment of various cell proliferative disorders. Disclosed in particular are methods for treatment of various cell proliferative disorders by administering a selective inhibitor of Aurora A kinase in combination with taxane-based chemotherapy, such as paclitaxel or docetaxel.
US10213433B2 Solid dispersions containing an apoptosis-inducing agent
A pro-apoptotic solid dispersion comprises, in essentially non-crystalline form, a Bcl-2 family protein inhibitory compound of Formula I as defined herein, dispersed in a solid matrix that comprises (a) a pharmaceutically acceptable water-soluble polymeric carrier and (b) a pharmaceutically acceptable surfactant. A process for preparing such a solid dispersion comprises dissolving the compound, the polymeric carrier and the surfactant in a suitable solvent, and removing the solvent to provide a solid matrix comprising the polymeric carrier and the surfactant and having the compound dispersed in essentially non-crystalline form therein. The solid dispersion is suitable for oral administration to a subject in need thereof for treatment of a disease characterized by overexpression of one or more anti-apoptotic Bcl-2 family proteins, for example cancer.
US10213431B2 Preservative free brimonidine and timolol solutions
The present invention is directed to preservative-free solutions of brimonidine and timolol for lowering intra-ocular pressure and treatment of glaucoma.
US10213430B2 Nucleotide analogs
Disclosed herein, inter alia, are acyclic nucleotide analogs and methods of using an acyclic nucleotide analog for treating and/or ameliorating a papillomavirus infection.
US10213427B2 Substituted imidazopyridazines and benzimidazoles as inhibitors of FGFR3
The present invention relates to substituted imidazopyridazines and substituted benzimidazoles, as well as pharmaceutical compositions comprising the same, which are FGFR3 inhibitors useful in the treatment of cancer and other diseases.
US10213426B2 Method of optimizing conditions for selectively removing a plurality of senescent cells from a tissue or a mixed cell population
Methods are provided herein for selectively killing senescent cells and for treating senescence-associated diseases and disorders by administering a senolytic agent. Senescence-associated diseases and disorders treatable by the methods using the senolytic agents described herein include cardiovascular diseases and disorders associated with or caused by arteriosclerosis, such as atherosclerosis; idiopathic pulmonary fibrosis; chronic obstructive pulmonary disease; osteoarthritis; senescence-associated ophthalmic diseases and disorders; and senescence-associated dermatological diseases and disorders.
US10213424B2 Morphine formulations
Provided herein, generally, are pharmaceutical formulations, e.g., injectable pharmaceutical formulations with improved stability, comprising morphine sulfate or a hydrate thereof, and methods of producing and using the same. Also provided herein are kits comprising the formulations, e.g., injectable morphine formulations.
US10213422B2 Compositions and methods of inhibiting histone deacetylases
The present invention provides compositions and methods for treating pulmonary hypertension. In one aspect, a method is included for increasing myocyte enhancer factor 2 (MEF2) activity in an endothelial cell comprising exposing the cell to a class IIa histone deacetylase inhibitor. In another aspect, a method is included for treating pulmonary hypertension, such as restoring MEF2 activity, in a subject in need thereof comprising administering to the subject a composition comprising a class IIa histone deacetylase inhibitor. Pharmaceutical compositions for treating pulmonary hypertension in a subject in need thereof and a kit for diagnosing, detecting and/or monitoring pulmonary hypertension are also included.
US10213418B2 Therapeutic uses of berberine formulations
Uses of pharmaceutical compositions comprising berberine for treatment of dermatologic toxicities and other skin disorders.
US10213417B2 Fatty acids as anti-inflammatory agents
Compounds of formula I and their metabolites are potent mediators of an inflammatory response: where a, b, c, d, e, f, V, W, X, Y, Ra, Ra′, Rb, Rb′, Rc, and Rc′ are defined herein. In particular, the compounds of the invention are candidate therapeutics for treating inflammatory conditions.
US10213409B2 Substituted benzofurans, benzothiophenes, benzoselenophenes and indoles and their use as tubulin polymerisation inhibitors
The present invention relates generally to substituted benzofurans, benzothiophenes, and indoles and their use as tubulin polymerization inhibitors.
US10213408B2 Nitroxyl donors with improved therapeutic index
The disclosed subject matter provides N-substituted hydroxylamine derivative compounds, pharmaceutical compositions and kits comprising such compounds, and methods of using such compounds or pharmaceutical compositions. In particular, the disclosed subject matter provides methods of using such compounds or pharmaceutical compositions for treating heart failure.
US10213406B2 α- and γ-truxillic acid derivatives and pharmaceutical compositions thereof
The present invention provides a compound, and method of inhibiting the activity of a Fatty Acid Binding Protein (FABP) comprising contacting the FABP with a compound, having the structure:
US10213405B2 Ophthalmic compositions and methods for treating eyes
Ophthalmic compositions including compatible solute components and/or polyanionic components are useful in treating eyes, for example, to relieve dry eye syndrome, to protect the eyes against hypertonic insult and/or the adverse effects of cationic species on the ocular surfaces of eyes and/or to facilitate recovery from eye surgery.
US10213404B2 Controlled release dosage form
The present invention provides a simple and improved dose form that is capable of providing a controlled release of GABAB receptor agonist contained in the core thereof. The invention also provides methods of administering the dosage form and of treating conditions that are therapeutically responsive to GABAB receptor agonist.
US10213403B2 Controlled release dosage form
The present invention provides a simple and improved dose form that is capable of providing a controlled release of GABAB receptor agonist contained in the core thereof. The invention also provides methods of administering the dosage form and of treating conditions that are therapeutically responsive to GABAB receptor agonist.
US10213402B2 Controlled release dosage form
The present invention provides a simple and improved dose form that is capable of providing a controlled release of GABAB receptor agonist contained in the core thereof. The invention also provides methods of administering the dosage form and of treating conditions that are therapeutically responsive to GABAB receptor agonist.
US10213401B2 Immunomodulatory and differentiating function selective retinoid and rexinoid compounds in combination with immune modulators for cancer immunotherapy
Disclosed herein are methods for treating cancer comprising administering CAR-modified immune cells and at least one Retinoic Acid Receptor and/or Retinoid X Receptor active agent.
US10213397B2 Microtubule polymerization modulators for treating LMNA-related dilated cardiomyopathy
Disclosed are methods and pharmaceutical compositions for treating cardiomyopathies. The disclosed methods and pharmaceutical compositions may be used for treating lamin A/C (LMNA)-related dilated cardiomyopathies (DCM) in a subject in need thereof. The disclosed methods may utilize and the disclosed pharmaceutical compositions may include an effective amount of a modulator of microtubule polymerization such as colchicine.
US10213395B2 Toxic aldehyde related diseases and treatment
The present invention provides for the treatment, prevention, and/or reduction of a risk of a disease, disorder, or condition in which aldehyde toxicity is implicated in the pathogenesis, including ocular disorders, skin disorders, conditions associated with injurious effects from blister agents, and autoimmune, inflammatory, neurological and cardiovascular diseases by the use of a primary amine to scavenge toxic aldehydes, such as MDA and HNE.
US10213394B1 Composition and method for treating neurological disease
The present disclosure is directed to methods of treating neurological disorders in a patient such as Parkinson's disease, drug-induced extrapyramidal reactions, and/or levodopa-induced dyskinesia comprising administering to the patient once daily in the morning a pharmaceutical composition comprising about 50 mg to about 400 mg of extended-release amantadine or a pharmaceutically acceptable salt thereof.
US10213384B2 Foamable vehicles and pharmaceutical compositions comprising aprotic polar solvents and uses thereof
The present invention teaches a foamable pharmaceutical and cosmetic compositions comprising an aprotic polar solvent; foam compositions and uses thereof.
US10213382B2 Nanosuspension of natural materials and preparation method thereof
The present disclosure relates to a method for the preparation of a nanosuspension of at least one natural material, wherein the method comprises the steps of (a) providing at least one natural material having a particle size (D90) of less than 320 μm; (b) dispersing said at least one natural material of step (a) in a solvent; and (c) milling the dispersion of step (b) to a particle size (D90) of below 1000 nm. The nanosuspension is useful for the preparation of a medicament.
US10213380B2 Method of treating ear pain
The present invention relates generally to a methods of treating ear infections and clearing excess fluid from Eustachian tubes.
US10213378B2 Single dose non-adjuvanted cutaneous tetanus vaccine and uses thereof
A method for preventing or treating tetanus infection in a subject, comprising administering a non-adjuvanted tetanus toxoid vaccine to the skin. The vaccine can be delivered by intradermal injection or microneedle patch and does not require cold storage.
US10213377B2 Topical skin compositions for treating wrinkles
A method of stimulating adipogenesis in a person's skin is disclosed. The method can include topically applying to skin in need thereof, a composition comprising an effective amount of Commiphora mukul resin or an extract thereof that includes oleo gum resin, wherein adipogenesis in the person's skin is stimulated.
US10213374B2 Oral care compositions and methods of use
Disclosed herein are oral care compositions comprising naringin:Zinc complexes having a 2:1 naringin to zinc molar ratio. Methods of making and using the compositions are also provided.
US10213373B2 Chromophore combinations for biophotonic uses
The present disclosure provides biophotonic compositions and methods useful in phototherapy. In particular, the biophotonic compositions of the present disclosure comprise at least two xanthene dyes. The biophotonic compositions and the method of the disclosure are useful for promoting wound healing and skin rejuvenation, as well as treating acne and other skin conditions.
US10213370B2 Dentifrice compositions with improved fluoride stability
A dentifrice composition containing water, calcium-containing abrasive, fluoride ion source, and alkaline metal carbonate with improved fluoride stability.
US10213369B2 Oral compositions containing metal ions
An oral care composition containing a stannous ion source, a zinc ion source, a polyphosphate, and a thickening agent. The thickening agent contains polyvinylpyrrolidone, a polysaccharide gum and carboxymethyl cellulose. The compositions have excellent rheology properties.
US10213360B2 Diagnostic and treatment methods
The present invention relates to a method of diagnosing the primary lesions that give rise to a chronic condition or incorrect structure in myofascial units and associated structures in a human patient. The invention also relates to a method of therapeutic treatment of the diagnosed conditions, in particular by application of a variable vacuum stimulus.
US10213359B2 Scar reduction apparatus
Post-scar formation reduction apparatus comprises a biocompatible scar interface layer, a compressible pressure chamber overlying the scar interface layer, and an at least substantially uniformly compressible pressure element in the pressure chamber which extends over the scar interface layer. The pressure element has a bulk modulus enabling a predetermined uniform or substantially uniform compression of the pressure element in at least a direction perpendicular or substantially perpendicular to the scar interface layer on application of a specific pressure. Evacuator is also provided which at least partially evacuates the pressure chamber, whereby the pressure element is uniformly or substantially uniformly compressed in the direction of the scar interface layer and the pressure chamber positively urges the compressed pressure element towards the scar interface layer.
US10213350B2 Radially tensioned wound or skin treatment devices and methods
Devices, kits and methods described herein may be for treatment to skin, including but not limited to wound healing, the treatment, amelioration, and/or prevention of scars or keloids. An applicator and/or tensioning device may be used to apply a dressing to a subject. The applicator and/or tensioning device applies and/or maintains a strain in an elastic dressing, wherein at least some of the strain is out-of-plane or at a non-orthogonal, non-parallel and non-aligned orientation to other strains in the dressing.
US10213348B2 Elastic structure for absorbent sanitary products, and a method and apparatus for its production
An elastic structure for absorbent sanitary products, comprising a sleeve comprising a first layer and a second layer overlapping each other, at least one elastic thread, and a plurality of first connecting portions spaced apart in a longitudinal direction, wherein each of said first connecting portions comprises two first welds arranged on opposite sides of the thread, wherein the first welds weld said first and second layers to each other in a first longitudinal portion of said sleeve, and a plurality of second connecting portions spaced apart in the longitudinal direction, wherein each of said second connecting portions comprises at least one second weld, wherein said second welds weld said first and second layers to each other in a second longitudinal portion of said sleeve without axially connecting the thread to said second longitudinal portion of the sleeve.
US10213347B2 Absorbent article with an apertured multi-layered topsheet
An absorbent article (100-1200) is capable of providing comfort to the wearer and can maintain dryness and inhibit the leakage of fluid. The absorbent article (100-1200) includes a multi-layered topsheet (138). The multi-layered topsheet (138) includes a first topsheet layer (106) having an opening (148) and a second topsheet layer (108) disposed under the first topsheet layer (106). The first topsheet layer (106) and the second topsheet layer (108) are joined together by a seal that, in one embodiment, generally corresponds with the shape of the opening (148). Further, a first sub-topsheet layer (116) is situated beneath the multi-layered topsheet (138) and has an opening (150) that is smaller than the first topsheet layer opening (148). This combination of openings (148, 150) situated one below the other provides for an absorbent article (100-1200) that can maintain a high level of dryness and its ability to conform to the wearer's body, and inhibit the leakage of bodily fluids due to a funnel-like effect.
US10213345B2 Apparatus and process for providing a coiled collagen carrier
The present invention relates inter alia to an apparatus for providing a coiled collagen carrier. An apparatus according to the invention preferably comprises a device for applying moisture to a collagen carrier prior to coiling of the collagen carrier and a coiling device. The coiling device preferably comprises rotatable gripping means for gripping the collagen carrier along an edge and coiling the collagen carrier, and a support device supporting the collagen carrier while being coiled. In another aspect, the invention relates to a production facility wherein an apparatus according to invention is arranged.
US10213343B2 Three-layered wound dressing and method of manufacturing the same
A three-layered wound dressing, including: a first layer, a second layer, and a third layer. The first layer includes a blend of first hydrophilic fibers and first hydrophobic fibers, the second layer includes a blend of second hydrophilic fibers and second hydrophobic fibers, and the third layer includes hydrophobic fibers. The second layer is disposed between the first layer and the third layer. In use, the first layer contacts a wound.
US10213328B2 Partial encapsulation of stents
A method of making an implantable medical device includes extruding a first ePTFE tube and a second ePTFE tube, cutting a plurality of slits in the first ePTFE tube, positioning a radially expandable support layer between the first and second ePTFE tubes so that the slits span portions of the support layer, and laminating the first ePTFE tube to the second ePTFE tube through openings in the support layer.
US10213325B2 Suspension liner with seal component
A suspension liner is provided for use as an interface between a residual limb and a prosthetic socket. The liner has an elongate, generally conical liner body formed from at least one material segment that is at least radially elastically extensible from a relaxed non-extended condition and including proximal and distal end areas, and a seal component connected to the liner body and having an exterior surface defining at least one exterior seal protruding from the exterior surface and extending radially outwardly from the seal component relative to a longitudinal axis of the liner body. The at least one interior seal is located along an interior surface of the seal component and defines at least one blade extending obliquely toward the liner body. A portion of the seal component carrying the interior seal extends freely and is movable relative to the liner body.
US10213324B2 Minimum jerk swing control for assistive device
We present a novel swing phase control module for powered transfemoral prostheses based on minimum jerk theory. The control module allows physiologically appropriate swing movement at any walking speed, regardless of the stance controller action. Preliminary validation in a transfemoral amputee subject demonstrates that the control module provides physiological swing timing, without speed or patient-specific tuning.
US10213322B2 Intervertebral disc and insertion methods therefor
A method of inserting an intervertebral disc implant into a disc space includes accessing a spinal segment having a first vertebral body, a second vertebral body and a disc space between the first and second vertebral bodies. The method includes securing a first pin to the first vertebral body and a second pin to the second vertebral body, using the first and second pins for distracting the disc space, and providing an inserter holding the intervertebral disc implant. The method also desirably includes engaging the inserter with the first and second pins, and advancing the inserter toward the disc space for inserting the intervertebral disc implant into the disc space, whereby the first and second pins align and guide the inserter toward the disc space.
US10213321B2 Bone fusion system, device and method including delivery apparatus
A bone fusion method, system and device for insertion between bones that are to be fused together and/or in place of one or more of the bones, such as, for example, the vertebrae of a spinal column. The bone fusion device comprises one or more extendable tabs having a central rib. The bone fusion device includes one or more support channels configured to receive an insertion instrument that is then secured to the bone fusion device via a coupling mechanism. As a result, the coupled device is able to be securely positioned between vertebrae using the insertion instrument with minimal risk of slippage.
US10213316B2 Prosthesis
A prosthesis for primary artrodhesis can be used for artroplasty and a prosthesis for artroplasty comprises members for artrodhesis. The prosthesis (1b) for primary artrodhesis comprises a locking member (33b) with an attachment portion (16b) which is insertable into a hole (8b) in a first attachment member (4b) of the prosthesis for location of the locking member therein, and a lockable member (34b) integral with a second attachment member (5b) of the prosthesis. The lockable member (34b) is configured for adjustable setting thereof relative to the locking member (33b) and for fixation thereof, in set position, to the locking member. Alternatively, the lockable member comprises an attachment portion which is insertable into a hole in the second attachment member for location of the lockable member therein. At the prosthesis for artroplasty, the hole in the first screw-like attachment member is partly configured to define a press fit with an attachment pin of a socket member and partly threaded to permit, after removal of the socket member, during artrodhesis, securing by screwing in the hole of the locking member for cooperation with a lockable member which is configured for adjustable setting thereof relative to the locking member and for fixation thereof, in set position, to the locking member.