最新美国发明专利第2014-04-08期 - 专利汇|PatentHub专利检索|专利查询网|发明专利查询分析

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US08692061B2	Plants and seeds of hybrid corn variety CH548933 According to the invention, there is provided seed and plants of the hybrid corn variety designated CH548933. The invention thus relates to the plants, seeds and tissue cultures of the variety CH548933, and to methods for producing a corn plant produced by crossing a corn plant of variety CH548933 with itself or with another corn plant, such as a plant of another variety. The invention further relates to genetic complements of plants of variety CH548933.
US08692059B2	Plants and seeds of hybrid corn variety CH409624 According to the invention, there is provided seed and plants of the hybrid corn variety designated CH409624. The invention thus relates to the plants, seeds and tissue cultures of the variety CH409624, and to methods for producing a corn plant produced by crossing a corn plant of variety CH409624 with itself or with another corn plant, such as a plant of another variety. The invention further relates to genetic complements of plants of variety CH409624.
US08692055B2	Plants and seeds of hybrid corn variety CH218560 According to the invention, there is provided seed and plants of the hybrid corn variety designated CH218560. The invention thus relates to the plants, seeds and tissue cultures of the variety CH218560, and to methods for producing a corn plant produced by crossing a corn plant of variety CH218560 with itself or with another corn plant, such as a plant of another variety. The invention further relates to genetic complements of plants of variety CH218560.
US08692052B2	Genetically modified mice and engraftment A mouse with a humanization of the mIL-3 gene and the mGM-CSF gene, a knockout of a mRAG gene, and a knockout of a mII2rg subunit gene; and optionally a humanization of the TPO gene is described. A RAG/II2rg KO/hTPO knock-in mouse is described. A mouse engrafted with human hematopoietic stem cells (HSCs) that maintains a human immune cell (HIC) population derived from the HSCs and that is infectable by a human pathogen, e.g., S. typhi or M. tuberculosis is described. A mouse that models a human pathogen infection that is poorly modeled in mice is described, e.g., a mouse that models a human mycobacterial infection, wherein the mouse develops one or more granulomas comprising human immune cells. A mouse that comprises a human hematopoietic malignancy that originates from an early human hematopoietic cells is described, e.g., a myeloid leukemia or a myeloproliferative neoplasia.
US08692050B2	Medicated patch A medicated patch is provided which is covered with a liner that enables one to remove the liner unconsciously and readily without losing the initial stickiness of the medicated patch. The external medicated patch includes a backing, an aqueous adhesive drug-containing matrix that is spread substantially entirely over one surface of the backing, and a liner that is larger in size than the surface of the drug-containing matrix to which the liner is attached. The liner larger in size than the surface of the drug-containing matrix to which the liner is attached includes an unattached area that extends from the surface of the drug-containing matrix, or an unattached slack portion that projects upward from the surface of the drug-containing matrix at a position on the surface of the drug-containing matrix.
US08692047B2	Method of purifying 8-isoprostane A method of purifying 8-isoprostane is provided that includes a step of contacting a liquid sample containing 8-isoprostane with an ion exchange support having a quaternary ammonium salt immobilized thereon such that 8-isoprostane in the liquid sample is retained on the ion exchange support and a step of eluting 8-isoprostane from the ion exchange support using a first eluent containing a water-soluble organic solvent and water as main components.
US08692046B2	Process for isomerizing a feed stream including one or more C4-C6 hydrocarbons One exemplary embodiment can be a process for isomerizing a feed stream including one or more C4-C6 hydrocarbons. The process may include contacting the feed stream in an isomerization reaction zone with an isomerization catalyst at isomerization conditions to produce an isomerization zone effluent; passing at least a portion of the isomerization zone effluent to a stabilizer zone and recovering a stabilizer overhead stream, a bottom stream, and a stripper feed stream; passing the stripper feed stream to a stripping zone and separating the stripper feed stream into a stripper overhead stream and a stripper bottom stream; and recycling at least a portion of the stripper bottom stream to a deisopentanizer zone and passing a stream from the deisopentanizer zone to the isomerization reaction zone. Usually, the stabilizer overhead stream includes one or more C5− hydrocarbons, the bottom stream includes at least about 85%, by weight, one or more C6+ hydrocarbons, and a stripper feed stream including at least about 10%, by weight, one or more C5+ hydrocarbons. Often, a stripper overhead stream includes at least about 5%, by weight, one or more C4− hydrocarbons and a stripper bottom stream includes at least about 90%, by weight, one or more C5+ hydrocarbons.
US08692042B2	Methods for producing cycloheptatriene This invention relates to methods for producing cycloheptatriene from at least 7,7-dichloronorcarane and a liquid component comprising a C8 to C30 succinic anhydride, a carboxylic acid, or a C8 to C30 alkyldimethylamine at about 205 deg. C. to about 230 deg. C.
US08692038B2	Fluorine-containing compound purification method There is provided a fluorine-containing compound purification method for obtaining a high-purity fluorine-containing compound by efficiently separating and removing hydrogen chloride from a fluorine-containing compound that contains hydrogen chloride, i.e., from a crude fluorine-containing compound. The fluorine-containing compound purification method of the present invention comprises the following steps (1) and (2) in this order: step (1): a step of adding dimethyl ether to a crude fluorine-containing compound that contains a fluorine-containing compound and hydrogen chloride in a molar ratio (dimethyl ether (mol)/hydrogen chloride (mol)) of dimethyl ether to hydrogen chloride being 1.3 or more to prepare a mixture (1) of the crude fluorine-containing compound and dimethyl ether; and step (2): a step of separating and removing a mixture (2) of hydrogen chloride and dimethyl ether from the mixture (1).
US08692037B2	Compositions comprising 1,1,1,2,3-pentafluoropropane or 2,3,3,3-tetrafluoropropene Disclosed are compositions comprising HFC-245eb and at least one additional compound selected from the group consisting of HFO-1234ze, HFC-245fa, HFC-236cb, HFC-236ea, HFC-236fa, HFC-227ea, HFC-227ca, HFO-1225yc, HFO-1225zc, HFO-1225ye, methane, ethane, propane, HFC-23, HFC-143a, HFC-134, HFC-134a, FC-1216, HFO-1234yf, HFC-254eb, HFO-1243zf, and HFC-254fb. Compositions comprising HFC-245eb are useful in processes to make HFO-1234yf. Also disclosed are compositions comprising HFO-1234yf and at least one additional compound selected from the group consisting of HFO-1234ze, HFC-254eb, HFC-254fb, HFO-1243zf, HFCHFC-245eb, HFC-245fa, HFC-245cb, HFC-236cb, HFC-236ea, HFC-236fa, HFC-227ea, HFC-227ca, HFO-1225yc, HFO-1225zc, HFO-1225ye, methane, ethane, propane, HFC-23, HFC-134, HFC-134a, HFO-1132a and FC-1216. Compositions comprising HFO-1234yf are useful as heat transfer compositions for use in refrigeration, air-conditioning and heat pump systems.
US08692036B2	Method for preparing 2,3-dimethyl-2,3-dinitrobutane The present invention relates to a method for preparing 2,3-dimethyl-2,3-dinitrobutane (DMNB), which includes the following steps: (1) making titanium-silicate molecular sieve catalyst, acetone, hydrogen peroxide and ammonia contact and react at 65-80° C. to obtain a modified titanium-silicate molecular sieve catalyst; and (2-1) making acetone oxime and hydrogen peroxide contact and react in the presence of the modified titanium-silicate molecular sieve catalyst and water under the conditions of temperature of 60-90° C. and pH of 8-10, and separating DMNB from the reaction products thereof; or (2-2) making acetone, ammonia and hydrogen peroxide contact and react in the presence of the modified titanium-silicate molecular sieve catalyst and water under the conditions of temperature of 60-90° C. and pH of 8-10, and separating DMNB from the reaction products thereof. By the method provided by the present invention, DMNB can be prepared without having to use dangerous chemicals, such as 2-nitropropane, NaH and the like.
US08692032B2	Methods of using tungsten carbide catalysts in preparation of ethylene glycol Tungsten carbide catalysts are used in preparation of ethylene glycol by hydrogenating degradation of cellulose. The catalyst includes tungsten carbide as main catalytic active component, added with small amount of one or more transition metals such as nickel, cobalt, iron, ruthenium, rhodium, palladium, osmium, iridium, platinum, and copper as the second metal, supported on one or more porous complex supports such as active carbon, alumina, silica, titanium dioxide, silicon carbide, zirconium oxide, for conversion of cellulose to ethylene glycol. The catalyst realizes high efficiency, high selectivity, and high yield in the conversion of cellulose to ethylene glycol at the temperature of 120-300° C., hydrogen pressure of 1-10 MPa, and hydrothermal conditions. Compared to the existing industrial synthetic method of ethylene glycol using ethylene as feedstock, the invention has the advantages of using renewable raw material resources, environment friendly process, and excellent atom economy.
US08692025B2	Process for preparing M- or P-substituted phenylalkanols by alkylation The invention relates to a process for the preparation of m- or p-substituted phenylalkanols of the formula (I) in which R1 is bonded to the phenyl ring in the m- or p-position and is C1-C5-alkyl, and R2, R3, R4 and R5, independently of one another, are hydrogen or methyl, wherein an unsubstituted phenylalkanol of the formula (II) in which R2, R3, R4 and R5 have the meanings given under formula (I) is alkylated together with a C1-C5-alkyl halide of the formula (III) R1-Hal (III), in which R1 has the meaning given under formula (I) and Hal is halogen, in the presence of a Friedel-Crafts catalyst to give an m- or p-alkyl-substituted phenylalkanol of the formula (I), then the reaction mixture is worked-up and the desired m- or p-alkyl-substituted phenylalkanol of the formula (I) is separated off, the other formed by-products are returned to the reaction mixture and these are isomerized in the presence of a Friedel-Crafts catalyst to give the desired m- or p-alkyl-substituted phenylalkanol. From the m- or p-alkyl-substituted phenylalkanols of the formula (I), it is possible to form, by oxidation or dehydrogenation, as products of value, the corresponding aldehydes, which play an interesting role as fragrances and aroma chemicals.
US08692023B2	Sugar metabolism improving composition, and pharmaceutical preparation containing said composition The purpose of the present invention is to provide a highly safe composition that improves glucose tolerance and sugar metabolism at skeletal muscles, and a prevention/treatment drug for diabetes/metabolic syndrome containing the composition. Provided is a composition that is for improving sugar metabolism and glucose tolerance and that contains a compound represented by formula (I) derived from a plant selected from the group consisting of Rumex japonicus, R. crispus, and R. obtusifolius as the active ingredient.
US08692021B2	Method of preparing Neramexane or a salt thereof Method of preparing 1-amino-1,3,3,5,5-pentamethylcyclohexane or a pharmaceutically acceptable salt thereof (Neramexane), comprising step (iv): (iv) hydrolyzing a mixture comprising an acid, 1-formamido-1,3,3,5,5-pentamethylcyclohexane and hydrogen cyanide to yield 1-amino-1,3,3,5,5-pentamethylcyclohexane.
US08692017B2	Carbon linked modulators of gamma-secretase The present invention relates to compounds of Formula I as shown below, wherein the definitions of A, X, R1, R3, R4, R5, R6, R7, R8, and R9 are provided in the specification. Compounds of Formula I are useful for the treatment of diseases associated with γ-secretase activity, including Alzheimer's disease.
US08692012B2	Method for producing ester-functional silanes Silanes containing an ester group are produced in high yield and purity by reacting a salt of a carboxylic acid with a silane containing a carboxylate substitutable leaving group following by distilling the product mixture to obtain a distillate containing the ester group containing silane product, wherein a solvent having a boiling point higher than the product is contained in the product mixture during at least a terminal portion of the distillation.
US08692010B1	Synthesis method for copper compounds Disclosed are synthesis methods to produce copper bis-ketoiminate and copper bis-ketiminate compounds.
US08692006B2	Thermal methods for treating a metathesis feedstock Various methods are provided for metathesizing a feedstock. In one aspect, a method includes providing a feedstock comprising a natural oil, heating the feedstock to a temperature greater than 100° C. in the absence of oxygen, holding the feedstock at the temperature for a time sufficient to diminish catalyst poisons in the feedstock, and, following the heating and holding, combining a metathesis catalyst with the feedstock under conditions sufficient to metathesize the feedstock.
US08692005B2	Catalyst for esteramine production Provided are methods for decreasing the reaction time between an alkanolamine such as triethanolamine and a fatty acid alkyl ester such as, a triglyceride, a vegetable oil, a methyl ester, an ethyl ester, etc., a fatty acid, or a mixture thereof. The methods utilize a divalent zinc catalyst to facilitate and accelerate an esterification or transesterification reaction between the alkanolamine and the fatty acid, or fatty acid alkyl ester.
US08692004B2	Process for purification of vegetable oils upon withdrawal of solids by centrifugation in the miscella stage Process for purification of vegetable oils upon withdrawal of solids by centrifugation in the miscella stage consists of the industrial extraction of vegetable oils, including the soybean oil by using a solvent, usually a mixture of hydrocarbons, in which the main constituent is hexane. The percolation extractors that operate continuously and in countercurrent provide an optimized extraction and a good performance. The replacement of the traditional miscella purification processes by a process of Centrifugation in the mixture of oil and solvent (miscella) within the process with the removal of solids contained therein, returning it to the extractor results in final products as oil and lecithin of a better quality, also providing a better functioning of the process by avoiding fouling in heat exchangers and distillation of solvent, reducing downtime and lower fuel consumption resulting in lower production costs.
US08692001B2	Sulfonamides for the modulation of PKM2 The invention relates to sulfonamide compounds and methods for activating PKM2. The compounds and methods are useful in treating or preventing a disease or disorder selected from cancer, cell proliferative disorder, inflammatory disorder, metabolic disorder, and immune system disorder.
US08691999B2	Process for the preparation of telmisartan An improved process for the preparation of telmisartan, or a pharmaceutically acceptable salt thereof, comprises subjecting 1H-Benzimidazole-2-n-propyl-4-methyl-6-(1′-methyl benzimidazole-2′yl)] of formula (II), and methyl-4-(bromomethyl)biphenyl-2-carboxylate of formula (III) to condensation and hydrolysis in a single step:
US08691997B2	Processes for producing 2-chloro-3-trifluoromethylpyridine The present invention provides processes for producing 2-chloro-3-trifluoromethylpyridine which is useful as an intermediate for medicines and agrochemicals, at a high production rate in a high yield. Specifically, the present invention relates to a process for producing 2-chloro-3-trifluoromethylpyridine or a salt thereof comprising allowing 3-trifluoromethylpyridine N-oxide to react with a chlorinating agent; and also relates to a process for producing 2-chloro-3-trifluoromethylpyridine or a salt thereof comprising oxidizing 3-trifluoromethylpyridine to produce 3-trifluoromethylpyridine N-oxide and subsequently allowing the obtained 3-trifluoromethylpyridine N-oxide to react with a chlorinating agent.
US08691996B2	Compound containing pyridine ring and method for producing halogenated picoline derivative and tetrazolyloxime derivative Disclosed is a compound containing a pyridine ring that can be synthesized in an industrially advantageous manner, and is useful as an intermediate for producing tetrazolyloxime derivatives that exhibit fungicidal activity (wherein R0 represents a C1-6 alkoxy group, C1-6 alkoxy-C1-6 alkoxy group or the like, R1 represents a C1-2 alkoxycarbonyl group, acetyl group or the like, Z represents a halogen atom, cyano group or the like, X represents a halogen atom, and n represents an integer of 0 to 3), and industrially advantageous production methods for producing 2-substituted amino-6-halomethylpyridine derivatives and tetrazolyloxime derivatives.
US08691992B2	Octahydro biquinoline compound The present invention relates to an octahydro biquinoline compound. Provided is also a method of separating the octahydro biquinoline compound into enantiomers. The octahydro biquinoline compound is of the general formula (V): In formula (V) R1 is one of H, a protective group and an aliphatic group, with the aliphatic group having a main chain of a length of 1 to about 10 carbon atoms, comprising 0 to about 6 heteroatoms selected from the group consisting of N, O, S, Se and Si. R2 and R3 are independent from one another selected from the group consisting of (i) H, (ii) one of an aliphatic, an alicyclic, an aromatic, an arylaliphatic, and an arylalicyclic group comprising 0 to about 6 heteroatoms selected from the group consisting of N, O, S, Se and Si, an ester, a carbonate group, a carbamoyl group and a phosphate ester. R4 and R5 are independent from one another H, an aliphatic, an alicyclic, an aromatic, an arylaliphatic or an arylalicyclic group comprising 0 to about 6 heteroatoms selected from the group consisting of N, O, S, Se and Si.
US08691990B2	6-heterocyclic imidazo[1,2-α]pyridine-2-carboxamide derivatives, preparation and therapeutic use thereof Compounds of formula (I): in which: X, R1, R2, R3 and R4 are as defined in the disclosure, or an acid addition salt thereof; and therapeutic use thereof.
US08691988B2	Metal complexes of cyclometallated imidazo (1,2-f) phenanthridine (1,2-a:1′, 2′-c),quinazoline ligands and isoelectronic and benzannulated analogs thereof Compounds comprising phosphorescent metal complexes comprising cyclometallated imidazo[1,2-f]phenanthridine and diimidazo[1,2-a:1′,2′-c]quinazoline ligands, or isoelectronic or benzannulated analogs thereof, are described. Organic light emitting diode devices comprising these compounds are also described.
US08691987B2	Method of producing polymeric phenazonium compounds A process of making a polymeric phenazonium compound having the general formula: wherein R1, R2, R4, R5, R6, R8 and R9 are the same or different, and represent hydrogen, a low alkyl or a substituted aryl, R3 starts with NH2 and is diazotized followed by polymerization, R5 and R8 may alternatively represent monomeric or polymeric phenazonium radicals, R7 with its substituent group is a substituted amine, with RX and RY representing any combination of CH3, C2H5, and hydrogen, except that RX and RY cannot both be hydrogen, A is an acid radical, and n is an integer from 2 to 100, preferably from 2 to 20 is described. The polymeric phenazonium compound is usable in as an additive in a metal plating bath. The method includes the steps of: a) dissolving an effective amount of an amino compound in a formic acid solution; b) adding a nitrite salt to diazotize the amino compound; and c) adding sulfamic acid to neutralize any excess nitrous acid that may be formed in step b), whereby a polymeric phenazonium compound is produced.
US08691979B2	Methods of chemical synthesis of diaminophenothiazinium compounds involving the use of persulfate oxidants Described are methods of synthesizing and purifying certain 3,7-diamino-phenothiazin-5-ium compounds (referred to herein as “diaminophenothiazinium compounds”) including Methylhioninium Chloride (MTC) (also known as Methylene Blue). In one embodiment, the method comprises the steps of, in order: a thiosulfonic acid formation (TSAF); an oxidative coupling (OC); and a ring closure (RC). Also described are resulting compounds and compositions comprising them (e.g., tablets, capsules) for use in methods of medical treatment and diagnosis, etc., for example, for tauopathies, or Alzheimer's disease (AD).
US08691976B2	Carbohydrate composition for flat glucose response A low-glycemic available carbohydrate composition of the invention contains the following components: (i) 5-60 wt. % of one or more monosaccharides selected from monosaccharides other than glucose and fructose, in particular galactose, ribose and mannose; (ii) 15-95 wt. % of oligosaccharides having a length of 2 to 20 anhydromonose units, at least half of which are anhydroglucose units linked by non-α-1,4 bonds; these oligosaccharides preferably comprising disaccharides such as palatinose, isomaltose and trehalose and/or non-α-1,4 linked higher glucose-containing oligosaccharides; (iii) 0-45 wt. % of other available carbohydrates, such as glucose and maltodextrins. This carbohydrate composition can be part of a food composition for the treatment of diabetes, obesitas, insulin resistance, or for postprandial glucose response.
US08691975B2	Solvent-free mechanochemical purification of compounds Methods for purifying and extracting compounds from a mixture are provided using a solvent-free mechanochemical method. Methods for purifying and/or extracting sugars, amino acids, and, the like, from a mixture are also provided, using a solvent-free mechanochemical method.
US08691974B2	Three-dimensional bioprinting of biosynthetic cellulose (BC) implants and scaffolds for tissue engineering A novel BC fermentation technique for controlling 3D shape, thickness and architecture of the entangled cellulose nano-fibril network is presented. The resultant nano-cellulose based structures are useful as biomedical implants and devices, are useful for tissue engineering and regenerative medicine, and for health care products. More particularly, embodiments of the present invention relate to systems and methods for the production and control of 3-D architecture and morphology of nano-cellulose biomaterials produced by bacteria using any biofabrication process, including the novel 3-D Bioprinting processes disclosed. Representative processes according to the invention involve control of the rate of production of biomaterial by bacteria achieved by meticulous control of the addition of fermentation media using a microfluidic system. In exemplary embodiments, the bacteria gradually grew up along the printed alginate structure that had been placed into the culture, incorporating it. After culture, the printed alginate structure was successfully removed revealing porosity where the alginate had been placed. Porosity and interconnectivity of pores in the resultant 3-D architecture can be achieved by porogen introduction using, e.g., ink-jet printer technology.
US08691973B2	Method of producing chitosan scaffold having high tensile strength and chitosan scaffold produced using the method Provided are a method of producing a porous chitosan scaffold, the method including: providing an aqueous acidic solution having chitosan and a solvent which does not dissolve the chitosan; and freeze-drying the aqueous acidic solution, wherein the solvent is selected from the group consisting of a C3-C8 aliphatic alcohol having one hydroxy group, ethylene glycol monoethylether, ethylene glycol monobutylether, dioxane, tetrahydrofuran, dimethylcarbonate, acetone and acetonitrile, and a chitosan scaffold produced using the method.
US08691967B2	Multiple promoter expression cassettes for simultaneous delivery of RNAi agents The present invention provides multiple-promoter expression cassettes for simultaneous delivery of RNAi, preferably to mammalian cells in vivo.
US08691966B2	RNA containing modified nucleosides and methods of use thereof This invention provides RNA, oligoribonucleotide, and polyribonucleotide molecules comprising pseudouridine or a modified nucleoside, gene therapy vectors comprising same, methods of synthesizing same, and methods for gene replacement, gene therapy, gene transcription silencing, and the delivery of therapeutic proteins to tissue in vivo, comprising the molecules. The present invention also provides methods of reducing the immunogenicity of RNA, oligoribonucleotide, and polyribonucleotide molecules.
US08691965B2	Oligonucleotides for modulating target RNA activity The present invention relates to oligonucleotides for modulation of target RNA activity. Thus, the invention provides oligonucleotides that bind to microRNA binding sites of target RNA. The oligonucleotides may activate RNase H or RNAi. In a preferred embodiment, the oligonucleotides prevents a microRNA from binding to its binding site of the target RNA and thereby prevent the microRNA from regulating the target RNA. Such oligonucleotides have uses in research and development of new therapeutics.
US08691961B1	Flavivirus reporter virus and methods of making and using the same The present invention relates to the production and uses of flavivirus replicons and flavivirus particles and reporter virus particles. The present invention relates to the production and uses of chimeric and codon-optimized flavivirus virus replicons and flavivirus virus particles and reporter virus particles.
US08691960B2	Oxidoreductases for enantioselective reactions Described herein are compositions and methods for generating oxidoreductases for enantioselective reactions. Described herein are compositions and methods for generating neomorphic (R)-2-hydroxyacid dehydrogenases capable of enzymatically converting a 1-carboxy-2-ketoacid to a 1-carboxy-(R)-2-hydroxyacid, or the reverse reaction. Illustrative examples include (a) (R)-2-hydroxyadipate dehydrogenase and uses thereof for converting 2-oxoadipate to (R)-2-hydroxyadipate, or the reverse reaction; and (b) (R)-2-hydroxyglutarate dehydrogenase and uses thereof for converting 2-oxoglutarate to (R)-2-hydroxyglutarate, or the reverse reaction. Also described herein are compositions and methods for generating non-natural microbial organisms to enzymatically convert 2-oxoadipate to (E)-2-hexenedioate or adipate, or to enzymatically convert 2-oxoglutarate to (E)-2-pentenedioate or glutarate, or the respective reverse reactions.
US08691956B2	Monoclonal antibody against human HIG-1 polypeptide This invention relates to a monoclonal antibody against a human HIG-1 polypeptide, the antibody binding to at least one epitope included in the amino acid sequence at positions 1-19 of a human HIG-1 polypeptide; an antibody fragment derived from the antibody; a DNA comprising a base sequence encoding a variable region of the antibody; an expression vector comprising the DNA; a cell line producing the antibody; a reagent for detecting a human HIG-1 polypeptide comprising the antibody or the antibody fragment, and a method for detecting a human HIG-1 polypeptide using the antibody or the antibody fragment.
US08691955B2	Use of α1G subunit of T-type calcium channel as diagnostic marker for pregnancy in cattle The present invention relates to a marker composition for pregnancy diagnosis in cattle, a pregnancy diagnosis composition, and a pregnancy diagnosis method, which use a pregnancy-specific protein in cattle. The present inventors discovered an α1G subunit protein of the T-type calcium channel expressed specifically in pregnant cows, and produced a specific antibody against this protein. Therefore, the present invention has the effect of detecting pregnancy in cows easily, quickly, and accurately early in the pregnancy.
US08691951B2	Type I-type IV collagen hybrid gel It is an object of the present invention to provide a Type I-Type IV collagen hybrid gel, which maintains characteristics of a Type IV collagen and is superior in gel strength. It is the Type I-Type IV collagen hybrid gel obtained by mixing 100 to 500 parts by mass of the Type I collagen having fibrosis ability, relative to 100 parts by mass of the Type IV collagen having gelling ability. A three-dimensional structure is formed, where a membrane-like substance by the Type IV collagen is formed onto a fibrous substance by the Type I collagen, so as to be able to provide cell culture environment approximate to a basement membrane of a living body.
US08691944B2	Fibronectin polypeptides and methods of use Described herein are fragments of fibronectin and variants thereof that bind growth factors. Compositions containing such a fragment of fibronectin are therefore useful in sequestering growth factors, and complexes containing both a FN fragment and a bound, active growth factor can be used to deliver growth factors to a patient (e.g., to a wound on the patient's skin).
US08691942B2	N- and C- terminal substituted antagonistic analogs of GH-RH There is provided a novel series of synthetic analogs of hGH-RH(1-29)NH2 (SEQ ID NO: 1) and hGH-RH(1-30)NH2. Of particular interest are those carrying PhAc, N-Me-Aib, Dca, Ac-Ada, Fer, Ac-Amc, Me-NH-Sub, PhAc-Ada, Ac-Ada-D-Phe, Ac-Ada-Phe, Dca-Ada, Dca-Amc, Nac-Ada, Ada-Ada, or CH3—(CH2)10—CO-Ada, at the N-Terminus and β-Ala, Amc, Apa, Ada, AE2A, AE4P, ε-Lys(α-NH2), Agm, Lys(Oct) or Ahx, at the C-terminus. These analogs inhibit the release of growth hormone from the pituitary in mammals as well as inhibit the proliferation of human cancers, and inhibit the hyperplastic and benign proliferative disorders of various organs, through a direct effect on the cancerous and non-malignant cells. The stronger inhibitory potencies of the new analogs, as compared to previously described ones, result from replacement of various amino acids.
US08691940B2	Relaxin polypeptides comprising non-naturally encoded amino acids Modified relaxin polypeptides and their uses are provided. In one aspect, the disclosure provides a relaxin polypeptide comprising one or more non-naturally encoded amino acids. The polypeptide may be linked to a linker, polymer, or biologically active molecule. The serum half-life of the relaxin polypeptide may be enhanced relative to the unconjugated form. In another aspect, the disclosure provides methods of treating a patient having a disorder modulated by relaxin.
US08691938B2	Anti-viral compounds Compounds effective in inhibiting replication of Hepatitis C virus (“HCV”) are described. This invention also relates to processes of making such compounds, compositions comprising such compounds, and methods of using such compounds to treat HCV infection.
US08691937B2	Method for the preparation of low odor copolymer latexes A method of preparing a low odor polymer latex composition includes the step of polymerizing a monovinylidene monomer, such as styrene, and a conjugated diene, such as butadiene, in the presence of a linear alkyl thiol chain transfer agent. The resulting polymer latex is treated with an oxidizing agent to oxidize residual chain transfer agent to volatile decomposition products that are then removed by steam stripping.
US08691932B2	Thermosetting monomers and compositions containing phosphorus and cyanato groups A thermosetting monomer comprising at least two of an aryl-cyanato group and at least two of a phosphorus group.
US08691927B2	Vinyl chloride resin with low viscosity for foaming application and method of preparing the same Provided are a vinyl chloride-based resin formed by polymerization of vinyl chloride-based small seed particles having an average particle diameter range of 0.15 μm to 0.5 μm prepared by emulsion polymerization and vinyl chloride-based large seed particles having an average particle diameter range of 0.51 μm to 0.8 μm prepared by micro-suspension polymerization, in which a content ratio (weight ratio) of the large seed particles to the small seed particles is in a range of 1 to 2, and a method of preparing the vinyl chloride-based resin. Excellent low viscosity characteristics of the vinyl chloride resin at high and low shear rates may be obtained by controlling the particle size of the small seed prepared by emulsion polymerization.
US08691924B2	Optical-use pressure-sensitive adhesive sheet The present invention provides an optical-use pressure-sensitive adhesive sheet, which includes a pressure-sensitive adhesive layer containing a polymer formed of one or more monomer ingredients containing, as an indispensable monomer ingredient, a monomer of which homopolymer has a glass transition temperature of not lower than −10° C., said sheet having a moisture content of at least 0.65% by weight after stored in an environment at 60° C. and 95% RH for 120 hours. The pressure-sensitive adhesive layer is preferably an acrylic pressure-sensitive adhesive layer.
US08691921B2	Polyurethane and manufacturing method therefor, master batch, ink binder, ink composition, thermoplastic polymer composition for molding, molded body, and composite molded body and manufacturing method therefor The present invention provides a polyurethane which is non-sticky, exhibits superior handling properties and superior moldability, and has superior adhesive properties with silicones even if a surface activation treatment is not carried out beforehand. The polyurethane of the present invention contains polyol units and organic polyisocyanate units. The polyol units contain an alkenyl group-containing organopolysiloxane structure in an amount ranging from 0.01 to 20% by weight with respect to the weight of the aforementioned polyurethane.
US08691917B2	Ionomers modified with imidized acrylic resins Compositions comprising ionomers and imidized acrylic resins are disclosed. Articles prepared from the compositions exhibit improved heat resistance properties such as increased Vicat temperature, increased stiffness/modulus at room temperature and elevated temperatures below the ionomer's melting point, and increased upper use temperature at a given stiffness over those of ionomers alone.
US08691916B2	Retortable easy opening seals for film extrusion A composition of matter particularly well suited for use as a peelable seal layer is described. The composition comprises from about 50 to about 85 percent by weight of a first polymer and from 15 to 50 percent of a second polymer. The first polymer is a propylene based polymer characterized by having a melting point of at least 125° C. together with a Comonomer Composition Distribution Breadth (“CCDB”) less than 2. The second polymer is characterized by having an interfacial adhesion with the first polymer of less than 1 lb/inch.
US08691913B2	Polylactic acid compositions, polylactic acid materials and methods of preparing the same A polylactic acid composition is provided having a polymer matrix and a compatibilizer. The polymer matrix includes polylactic acids and acrylonitrile-butadiene-styrene[s]. The compatibilizer is at least one compound selected from the group consisting of: a poly (styrene-ethylene-butadiene-styrene) copolymer grafted with maleic anhydrides, an acrylonitrile-butadiene-styrene copolymer grafted with maleic anhydrides, a polystyrene grafted with maleic anhydrides, and an ethylene-ethyl acrylate-glycidyl methacrylate.
US08691911B2	Melt-blended thermoplastic composition Disclosed is a melt-blended thermoplastic composition including: A) a polyamide composition including a) 55 to 90 weight percent semi-crystalline semi-aromatic copolyamide; wherein the semi-aromatic copolyamide has a DMA tan delta peak value of greater than or equal to 0.23; and heat of fusion of at least 20 J/g and b) 10 to 45 weight percent aliphatic homopolyamide; wherein the aliphatic homopolyamide has a DMA tan delta peak value of less than or equal to 0.21; and heat of fusion of at least 30 J/g; B) 0 to 45 weight percent polymeric toughener; C) 0 to 20 weight percent plasticizer; and D) 0 to 45 weight percent reinforcing agent; wherein said melt-blend composition has a glass transition and has a tan delta peak (E″/E′) value of 0.21 or lower at said glass transition. Further disclosed herein is a method for providing the melt-blended thermoplastic composition.
US08691907B2	Water-borne primer A water-borne stain blocking primer comprises a) from about 10 to about 30 wt % of a water-dispersible, hydrophobic alkyd resin having an acid number of less, than 40 KOH/g, b) from about 5 to about 30 wt % of a pigment, the pigment having an average aspect ratio of at least 3:3:1; c) from about 0.05 to about 3 wt % of a tannin chelation agent; d) from about 0 to about 20 wt % of a water-dispersible, hydrophobic free-radically polymerized copolymer; e) a hydrophobically modified associative rheology modifier in an amount effective to provide a water-borne primer having an ICI viscosity of from about 0.5 to about 3.0 poise; and a KU viscosity range of from about 80 to about 120 Krebs units; and f) water. The water-borne primer has a VOC content of less than 5%. Methods of preparing and using such water-borne stain blocking primers also are described.
US08691906B2	Method for producing an monofilament and use of the monofilament A process for producing at least one monofilament from a thermoplastic polymer material comprising at least one polyester and also nanoparticles and optionally further additives as components, comprises adding the components to an extruder as partial or complete mixtures or separately and the thermoplastic polymer material being initially strand extruded, cooled and stretched and finally heat-conditioned at a temperature in the range from 40 to 120° C. for 0.01 to 10 min. The invention further relates to using a monofilament obtained by the process in the manufacture of artificial turf, wigs and also as bristles for soft or stiff brushes.
US08691903B2	VOC-free coalescing agent A film-forming composition including a coalescent aid comprising fatty acid esters of ethylene glycol and/or propylene glycol having the formula R1COO[(EO)x(PO)y]zH wherein R1CO is a linear saturated aliphatic acyl group, or a combination thereof, having from about 6 to about 22 carbon atoms, EO is —CH2CH2O—, PO is —CH2CH(CH3)O— or —CH(CH3)CH2O— or a combination thereof, where the acyl radical is bonded to a carbon atom of the EO or PO radical, and x=0 to about 5, y=about 0 to about 5, the sum of x and y is equal or greater than 0.5, z=1 to about 5, and (x+y)z is less than or equal to 6. It is to be understood that x, y, and z are average values for the composition.
US08691896B2	Halogen-free, phosphorus-containing flame-retardant polymer foams Disclosed is a polymer foam with density in the range from 5 to 120 kg/m3 composed of a polymer component including at least one styrene polymer and from 0.1 to 5 parts by weight of a flame retardant mixture including at least one phosphorus compound of the formula PR1R2R3. A process for producing the polymer is also disclosed.
US08691894B2	Preparation of polyamide block copolymers This invention relates to the preparation of polyamide block copolymers by sequential monomer addition. More particularly, it relates to catalysts capable of copolymerizing not only cyclic amides, but other monomers such as cyclic esters and epoxides as well, using sequential addition so as to produce useful and novel block copolymers.
US08691893B2	Biodegradable composite materials A method of making a biodegradable composite is carried out by: (a) providing an aqueous mixture comprising partially hydrolyzed cellulose in a dissolution media; (b) providing a solution comprising a aliphatic polyester in a polar organic solvent; (c) combining the mixture with the solution to form a precipitate; (d) washing the precipitate with water to remove solvent and dissolution media and form a wet biodegradable composite; and then (e) drying the wet biodegradable composite to form a dry biodegradable composite. Composites made from the method are also described.
US08691884B2	Crosslinked flame retardant thermoplastic elastomer gels Crosslinked flame retardant thermoplastic elastomer gels are provided. The crosslinked flame retardant thermoplastic elastomer gels comprise a char catalyst, a char former, a maleic anhydride-modified styrene ethylene/butylene styrene polymer, and a softener oil. Methods are provided of making crosslinked flame retardant thermoplastic elastomer gels.
US08691880B2	Silicone dispersions A non-aqueous silicone emulsion is provided. It comprises a continuous phase of a polar organic liquid containing droplets of an organopolysiloxane dispersed therein. An organic wax, which has a melting point in the range 40 to 100° C. and is sparingly soluble in the polar organic liquid at 25° C., is dispersed in the polar organic liquid continuous phase as a network of interconnected particles which stabilizes the organopolysiloxane droplets in emulsion in the polar organic liquid. A process for the production of the emulsion is also disclosed.
US08691870B2	Use of isothiocyanates for treating cancer Novel Uses of small molecules, particularly, 6-methylsulfinylhexyl isothiocyanate and 6-methylsulfonylhexyl isothiocyanate, are disclosed herein. The two isothiocyanates are useful as lead compounds for manufacturing a medicament or a pharmaceutical composition for treating cancer, particularly drug-resistant cancer, in a patient.
US08691869B2	Pharmaceutical formulation of nitrooxyderivatives of NSAIDs The present invention relates to a pharmaceutical formulation comprising: a) one or more NO-releasing NSAID(s) of formula (I); b) one or more surfactants; c) a carbonyl scavenger compound selected from free acid forms, salts, carboxylic acid esters derivatives of a compound of formula (II) H2N—(CH2)m—(C6H4)—COOH (II) wherein m=0-10; and d) optionally an oil or semi-solid fat and/or a short-chain alcohol.
US08691867B2	Use of benzo-fused heterocycle sulfamide derivatives for the treatment of substance abuse and addiction The present invention is a method for the treatment of alcohol abuse and/or addiction comprising administering to a subject in need thereof a therapeutically effective amount of one or more novel benzo-fused heterocycle sulfamide derivatives of formula (I) and/or formula (II) as herein defined.
US08691865B2	Substituted octahydrocyclopenta[C]pyrrol-4-amines as calcium channel blockers The present application relates to calcium channel inhibitors containing compounds of formula (I) wherein L1, L2, R1, R2, and R3 are as defined in the specification. The present application also relates to compositions comprising such compounds, and methods of treating conditions and disorders using such compounds and compositions.
US08691864B2	Agents useful for reducing amyloid precursor protein and treating dementia and methods of use thereof The present invention provides compounds and methods of administering compounds to a subject that can reduce βAPP production and that is not toxic in a wide range of dosages. The present invention also provides non-carbamate compounds and methods of administering such compounds to a subject that can reduce βAPP production and that is not toxic in a wide range of dosages. It has been discovered that either the racemic or enantiomerically pure non-carbamate compounds can be used to decrease βAPP production.
US08691861B2	Prodrugs of inhibitors of plasma kallikrein This invention provides new pharmaceutically useful compounds that are prodrugs of inhibitors of plasma kallikrein and methods and compositions for preventing or treating plasma kallikrein dependent diseases or conditions, such as diabetic macular edema or hemorrhagic stroke, by administering prodrugs of the formula:
US08691859B2	Broad spectrum antibacterial compounds Disclosed herein are methods of inhibiting, reducing or preventing growth of or destroying bacteria of at least one bacterial strain which comprises contacting the bacteria with the compounds disclosed herein. Also disclosed are methods of treating, inhibiting or preventing an infection or intoxication caused by bacteria of at least one bacterial strain in a subject and pharmaceutical and cosmetic compositions comprising the compounds disclosed herein.
US08691856B2	Glucagon receptor antagonists, preparation and therapeutic uses The present invention discloses novel compounds of Formula (I), or pharmaceutically acceptable salts thereof, which have glucagon receptor antagonist or inverse agonist activity, as well as methods for preparing such compounds. In another embodiment, the invention discloses pharmaceutical compositions comprising compounds of Formula (I) as well as methods of using them to treat diabetic and other glucagon related metabolic disorders, and the like.
US08691855B2	Compounds, isomer thereof, or pharmaceutically acceptable salts thereof as vanilloid receptor antagonist and pharmaceutical compositions containing the same This present invention relates to novel compounds, isomer thereof or pharmaceutically acceptable salts thereof as vanilloid receptor (Vanilloid Receptor 1; VR1; TRPV1) antagonist; and a pharmaceutical composition containing the same. The present invention provides a pharmaceutical composition for preventing or treating a disease such as pain, migraine, arthralgia, neuralgia, neuropathies, nerve injury, skin disorder, urinary bladder hypersensitiveness, irritable bowel syndrome, fecal urgency, a respiratory disorder, irritation of skin, eye or mucous membrane, stomach-duodenal ulcer, inflammatory diseases, ear disease, heart disease and so on.
US08691849B2	3-azabicyclo[3.1.0]hexyl derivatives as modulators of metabotropic glutamate receptors The present invention relates to novel compounds, in particular novel pyridinone derivatives according to Formula (I) wherein all radicals are as defined in the application and claims. The compounds according to the invention are positive allosteric modulators of metabotropic receptors—subtype 2 (“mGluR2”) which are useful for the treatment or prevention of neurological and psychiatric disorders associated with glutamate dysfunction and diseases in which the mGluR2 subtype of metabotropic receptors is involved. In particular, such diseases are central nervous system disorders selected from the group of anxiety, schizophrenia, migraine, depression, and epilepsy. The invention is also directed to pharmaceutical compositions and processes to prepare such compounds and compositions, as well as to the use of such compounds for the prevention and treatment of such diseases in which mGluR2 is involved.
US08691845B2	Tetra-O-substituted butane-bridge modified NDGA derivatives, their synthesis and pharmaceutical use The present invention relates to nordihydroguaiaretic acid derivative compounds, namely, butane bridge modified nordihydroguaiaretic acid (NDGA) compounds and butane bridge modified tetra-O-substituted NDGA compounds, pharmaceutical compositions containing them, methods of making them, and methods of using them and kits including them for the treatment of diseases and disorders, in particular, diseases resulting from or associated with a virus infection, such as HIV infection, HPV infection, or HSV infection, an inflammatory disease, such as various types of arthritis and inflammatory bowel diseases, metabolic diseases, such as diabetes and hypertension, or a proliferative disease, such as diverse types of cancers.
US08691844B2	Method for treating thrombosis and inhibiting platelet aggregation with 21-(S)-argatroban A method for inhibiting coagulation including administering to a patient in need thereof a pharmaceutical composition containing 21-(S)-Argatroban and/or a pharmaceutically acceptable salt thereof. Compared with 21-(R)-Argatroban, 21-(S)-Argatroban significantly prolongs coagulation time of whole blood (CT), recalcification time (RT), kaolin partial thromboplastin time (APTT), pro-time prothrombin time (PT), thrombin time (TT), and reduces platelet adhesion rate and platelet aggregation rate in healthy dogs. Therefore, 21-(S)-Argatroban has a stronger effect for inhibiting coagulation and reducing therapeutically effective dose and is suitable for use in a method for treatment and/or prevention of thrombosis and inhibiting platelet aggregation.
US08691840B2	N-biarylamides The invention relates to N-biarylamides useful for the prophylaxis and/or treatment of impairments of perception, concentration, learning and/or memory, and to processes for preparing them, and pharmaceutical compositions containing them.
US08691839B2	Aminotetraline derivatives The present application relates generally to amino tetraline derivative compounds and methods of use, specifically, embodiments including compounds of formula (I) described herein, pharmaceutically acceptable salts and solvates. More specifically, this application relates to amino tetraline derivative compounds and uses of such compounds producing medicaments for the treatment of various disease and conditions including movement disorders and disorders of the central nervous system.
US08691837B2	Substituted imidazo ring systems and methods Imidazo ring systems substituted at the 1-position, pharmaceutical compositions containing the compounds, intermediates, methods of making the compounds, and methods of use of these compounds as immunomodulators, for inducing cytokine biosynthesis in animals and in the treatment of diseases including viral and neoplastic diseases are disclosed.
US08691835B2	4 aminopyridine and a pharmaceutical composition for treatment of neuronal disorders A composition is provided having the formula where R1 in each occurrence is independently H or a C1-C4 hydrocarbon; R3 is H, and R4 is a moiety capable of crossing the blood brain barrier selected from the group consisting of: an amino acid, a peptide, transferrin, gluconate, lactate, citrate, malate, fumarate, benzoate, salicylate, pyruvate and propionate. The composition includes 4-aminopyridine and a transporter species which allows for improved transport of the aminopyridine across the blood brain barrier thereby reducing systemic side effects of aminopyridine administration.
US08691834B2	Combinations of pyrimethanil and monoterpenes The present invention relates to combinations of pyrimethanil, or a salt thereof, and a monoterpene, or a salt thereof, which provide an improved biocidal effect. More particularly, the present invention relates to compositions comprising a combination of pyrimethanil, or a salt thereof, together with a monoterpene selected from thymol and β-thujaplicin in respective proportions to provide a synergistic biocidal effect. Compositions comprising these combinations are useful for the protection of any living or non-living material, such as crops, plants, fruits, seeds, objects made of wood, thatch or the like, engineering material, biodegradable material and textiles against deterioration due to the action of microorganisms such as bacteria, fungi, yeasts, algae, virusses, and the like.
US08691833B2	Heterocyclic aspartyl protease inhibitors Disclosed are compounds of the formula I or a stereoisomer, tautomer, or pharmaceutically acceptable salt or solvate thereof, wherein each variable in Formula 1 are as defined in the specification; and pharmaceutical compositions comprising the compounds of formula I. Also disclosed are methods of inhibiting aspartyl protease, and in particular, the methods of treating cardiovascular diseases, cognitive and neurodegenerative diseases, and the methods of inhibiting of Human Immunodeficiency Virus, plasmepins, cathepsin D and protozoal enzymes. Also disclosed are methods of treating cognitive or neurodegenerative diseases using the compounds of formula I in combination with a cholinesterase inhibitor or a muscarinic m1 agonist or m2 antagonist.
US08691828B2	Thienopyrimidine as CDC7 kinase inhibitors The present invention relates to a compound represented by the formula (I): wherein each symbol is as defined in the specification, or a salt thereof, or a prodrug thereof, which is useful for the prophylaxis or treatment of cancer.
US08691826B2	Compounds Compounds of formula (I): are useful as inhibitors of human neutrophil elastase.
US08691822B2	Dihydropteridinone derivatives, preparation process and pharmaceutical use thereof Dihydroperidinone derivatives, preparation process and pharmaceutical use thereof are disclosed. Specially, new dihydroperidinone derivatives represented by general formula (I), wherein each substituent of the general formula (I) is defined as in the description, their preparation process, pharmaceutical compositions comprising said derivatives and their use as therapeutical agents, especially as Plk kinase inhibitors are disclosed.
US08691821B2	Oxazolidinones as modulators of mGluR5 The disclosure generally relates to compounds of formula I, including their salts, as well as compositions and methods of using the compounds. The compounds are ligands, agonists and partial agonists for the mGluR5 receptor and may be useful for the treatment of various disorders of the central nervous system.
US08691818B2	Cyclic triazo and diazo sodium channel blockers Compounds of general structure in which X and Y are each N or C with at least one of X and Y being N; Z is a single bond or an optionally substituted linking group R1 is hydrogen or a substituent group; R2 is amino or a substituent group; N* is amino when RI is hydrogen or ═NH when R1 is a substituent group; or N* is a group NRaRb where Ra and Rb are independently H or an alkyl group; or N* is an optionally substituted piperazinyl ring; and A is an optionally substituted heterocyclic or carbocyclic ring system which may be linked to the triazo/diazo ring through R2 to form a fused multicyclic ring; are indicated as suitable for treatment of disorders in mammals that are susceptible to sodium channel blockers and antifolates, and particularly disorders such epilepsy, multiple sclerosis, glaucoma and uevitis, cerebral traumas and cerebral ischaemias, stroke, head injury, spinal cord injury, surgical trauma, neurodegenerative disorders, motorneurone disease, Alzheimer's disease, Parkinson's disease, chronic inflammatory pain, neuropathic pain, migraine, bipolar disorder, mood, anxiety and cognitive disorders, schizophrenia and trigeminal autonomic cephalalgias; for treatment of mammalian cancers; and for treatment of malaria.
US08691813B2	Indole and benzoxazine derivatives as modulators of metabotropic glutamate receptors The present invention relates to novel indole and benzoxazine derivatives which are positive allosteric modulators of the metabotropic glutamate receptor subtype 2 (“mGluR2”) and which are useful for the treatment or prevention of neurological and psychiatric disorders associated with glutamate dysfunction and diseases in which the mGluR2 subtype of metabotropic receptors is involved. The invention is also directed to pharmaceutical compositions comprising such compounds and to the use of such compounds and compositions for the prevention or treatment of neurological and psychiatric disorders and diseases in which mGluR2 is involved.
US08691806B2	Pyrazole derivatives as protein kinase modulators The invention provides compounds of the formula (I) having protein kinase B inhibiting activity: Also provided are pharmaceutical compositions containing the compounds, methods for preparing the compounds and their use as anticancer agents.
US08691804B2	Azetidines and cyclobutanes as histamine H3 receptor antagonists The invention relates to compounds of formula (I) wherein R, R0, R1, m, n and X1 to X4 have the meaning as cited in the description and the claims. These compounds are useful as Histamine H3 receptor antagonists. The invention also relates to pharmaceutical compositions, the preparation of such compounds as well as the production and use as medicament.
US08691802B2	Stabilized compositions comprising a therapeutically active agent and an oxidizing preservative Citric acid and conjugate bases thereof are useful for stabilizing stabilized chlorine dioxide in the presence of therapeutically active agents and excipients in a composition. Ophthalmic compositions and methods related thereto are also disclosed herein.
US08691801B2	Use of manzamine compounds in anti-cancer therapeutic regimens Manzamine compounds have been discovered to decrease cell dissociation and cell migration associated with the metastatic potential of cancer cells and a restoration of cancer cell susceptibility to agents, such as TRAIL, which can induce apoptosis. Specifically, Manzamine A has a formerly unrecognized utility in both blocking tumor cell invasion and tumor metastasis as well in restoring cancer cell susceptibility to standard chemotherapeutic agents which induce apoptosis and, therefore, has utility in treating cancer.
US08691800B2	Quinoline derivatives as antibacterial agents Use of a compound for the manufacture of a medicament for the treatment of a bacterial infection provided that the bacterial infection is other than a Mycobacterial infection, said compound being a compound of Formula (Ia) or (Ib) a pharmaceutically acceptable acid or base addition salt thereof, a quaternary amine thereof, a stereochemically isomeric form thereof, a tautomeric form thereof or a N-oxide form thereof, wherein R1 is hydrogen, halo, haloalkyl, cyano, hydroxy, Ar, Het, alkyl, alkyloxy, alkylthio, alkyloxyalkyl, alkylthioalkyl, Ar-alkyl or di(Ar)alkyl; p is 1, 2, 3 or 4; R2 is hydrogen, hydroxy, thio, alkyloxy, alkyloxyalkyloxy, alkylthio, mono or di(alkyl)amino or a radical of formula R3 is alkyl, Ar, Ar-alkyl, Het or Het-alkyl; R4 is hydrogen, alkyl or benzyl; R5 is hydrogen, halo, haloalkyl, hydroxy, Ar, alkyl, alkyloxy, alkylthio, alkyloxyalkyl, alkylthioalkyl, Ar-alkyl or di(Ar)alkyl; or two vicinal R5 radicals may be taken together to form together with the phenyl ring to which they are attached a naphthyl; r is 1, 2, 3, 4 or 5; R6 is hydrogen, alkyl, Ar or Het; R7 is hydrogen or alkyl; R5 is oxo; or R7 and R5 together form the radical —CH═CH—N═; Z is CH2 or C(═O).
US08691795B2	Process for producing sugar chain derivative, structure analysis method, and sugar chain derivative A process for preparing an oligosaccharide derivative from an oligosaccharide mixture, the process being characterized in that the process comprises the steps of (a) introducing a lipophilic group into oligosaccharides of the mixture to obtain a mixture of oligosaccharide derivatives, and (b) treating the oligosaccharide derivative mixture by serotonin affinity column chromatography.
US08691794B2	Topical composition for skin containing polysaccharide extract of red ginseng The present invention relates to a composition for skin application, which has the effects of reducing skin wrinkles, enhancing skin elasticity and preventing skin aging, and more particularly, to a composition for skin application, which contains, as an active ingredient, a polysaccharide extract of red ginseng having a molecular weight of less than 10,000, in which the polysaccharide extract of red ginseng has the effect of increasing the expression of mitochondrial electron transport system enzymes in human skin keratinocytes to enhance the activity of the skin cells, thereby reducing skin wrinkles, increasing skin elasticity and preventing skin aging.
US08691791B2	Microspheres for treatment of brain tumors There is provided a new use of microspheres comprising a water-insoluble, water-swellable polymer which is anionically charged at pH7, and electrostatically associated with the polymer, in releasable form, a cationically charged chemotherapeutic agent, in the manufacture of a composition for use in the treatment of a brain tumor, wherein in the treatment the composition is introduced into the brain and the chemotherapeutic agent is released from the microspheres, wherein the microspheres, when equilibrated in water at 37° C., comprise at least 40 wt % water based on weight of polymer plus water. Compositions comprising the microspheres and methods for the treatment of brain tumors are also provided.
US08691789B2	Probe of iodine-123 marker thymidine (FLT)analogue [123I]-IaraU A tumor radiation probe of iodine-123 marker thymidine (FLT) analogue [123I]-IaraU is disclosed. Commercial available uridine is used as the raw material for the synthesis of the precursor. A radioactive iodine-123 is marked on an alkaline group of uridine to obtain [123I]-IaraU, which is distinguishable from [18F]-FLT marking 18F on a glycosyl group to obtain a novel tumor radiation probe. The marking procedures include mixing the marker precursor with Na [123I] solution, acetic acid and hydrogen peroxide solution, and the solution of chloroform and sodium hydroxide. The sonication time increases from 1 minute to 10 minutes, so that [123I]-IaraU has radiologically chemical purity of higher than 98% and radiological specific activity of not less than 0.196 GBq/umole, and the yield can increase from 8% to 40%. Its radioactive specific activity, yield and purity reach to the degree for the use in biological experiments, while reducing production cost.
US08691785B2	Compositions and methods for non-parenteral delivery of oligonucleotides The present invention relates to compositions and methods which enhance the local and systemic uptake and delivery of oligonucleotides and nucleic acids via non-parenteral routes of administration. Pharmaceutical compositions comprising oligonucleotides disclosed herein include, for systemic delivery, emulsion and microemulsion formulations for a variety of applications and oral dosage formulations. It has also surprisingly been discovered that oligonucleotides may be locally delivered to colonic sites by rectal enemas and suppositories in simple solutions, e.g., neat or in saline. Such pharmaceutical compositions of oligonucleotides may further include one or more penetration enhancers for the transport of oligonucleotides and other nucleic acids across mucosal membranes. The compositions and methods of the invention are utilized to effect the oral, buccal, rectal or vaginal administration of an antisense oligonucleotide to an animal in order to modulate the expression of a gene in the animal for investigative, therapeutic, palliative or prophylactic purposes.
US08691784B2	MCP-1 binding nucleic acids The present invention is related to a nucleic acid, preferably binding to MCP-1, selected from the group consisting of Type 1A nucleic acids, type 1B nucleic acids, Type 2 nucleic acids, Type 3 nucleic acids, Type 4 nucleic acids and nucleic acids comprising SEQ ID NOs:87-115.
US08691780B2	Txr1 and enhanced taxane sensitivity based on the modulation of a pathway mediated thereby Methods and compositions for enhancing taxane sensitivity are provided. Aspects of the subject methods include administering to a subject a txr1 pathway modulatory agent in conjunction with a taxane. Also provided are txr1 polypeptides and nucleic acids encoding the same. The subject methods and compositions find use in a variety of different applications.
US08691778B2	Flurbiprofen and muscle relaxant gel combinations thereof A topical pharmaceutical gel includes flurbiprofen or a pharmaceutically acceptable salt of flurbiprofen, thiocolchicoside or a pharmaceutically acceptable salt of thiocolchicoside, and menthol. Pharmaceutical combinations of flurbiprofen, thiocolchicoside, and menthol in the form of topical gels with anti-inflammatory, analgesic, and myorelaxant activities are described.
US08691777B2	Combination therapy The disclosure relates to methods of treating tuberous sclerosis in a subject, comprising administering a composition comprising an mTOR inhibitor and a tyrosine kinase inhibitor to a subject that is diagnosed with, suspected of, or exhibiting symptoms of cancer. In some embodiments, the cancer is tuberous sclerosis. In some embodiments, the mTOR inhibitor is sirolimus and the tyrosine kinase inhibitor is imatinib. In some embodiments, the disclosure relates to a composition comprising an mTOR inhibitor and a tyrosine kinase inhibitor. In some embodiments, the disclosure relates to a composition comprising sirolimus and imatinib.
US08691775B2	Use of drugs that activate P2Y receptors to enhance synaptogenesis The present invention encompasses compositions and methods that activate P2Y receptors for the increased production of new synapses in the central nervous system. The formulations of the invention may be administered to a healthy subject or to a subject in need thereof to restore synapses.
US08691774B2	Carbohydrate profile compositions from human cells and methods for analysis and modification thereof The invention describes methods for production of novel composition of glycans, glycomes, from human multipotent stem cells. The invention is further directed to methods for modifying the glycomes and analysis of the glycomes and the modified glycomes. Furthermore the invention is directed to stem cells carrying the modified glycomes on their surfaces.
US08691771B2	Bi-specific fusion proteins for tissue repair Bi-specific fusion proteins with therapeutic uses are provided, as well as pharmaceutical compositions comprising such fusion proteins, and methods for using such fusion proteins to repair damaged tissue. The bi-specific fusion proteins generally comprise: (a) a targeting polypeptide domain that binds to an ischemia-associated molecule; and (b) an activator domain that that detectably modulates the activity of a cellular network.
US08691767B2	Use of erythropoietin and substances increasing and/or prolonging the activation and/or stimulation of erythropoietin receptors for treating and/or preventing schizophrenia and related psychoses Method for treatment and/or prophylaxis of schizophrenia and related psychoses of a human being, erythropoietin being administered to the human being.
US08691766B2	Biglycan and related therapeutics and methods of use The invention provides compositions and methods for treating, preventing, and diagnosing diseases or conditions associated with an abnormal level or activity of biglycan; disorders associated with an unstable cytoplasmic membrane, due, e.g., to an unstable dystrophin associated protein complex (DAPC); disorders associated with abnormal synapses or neuromuscular junctions, including those resulting from an abnormal MuSK activation or acetylcholine receptor (AChR) aggregation. Example of diseases include muscular dystrophies, such as Duchenne's Muscular Dystrophy, Becker's Muscular Dystrophy, neuromuscular disorders and neurological disorders.
US08691765B2	Metallothionein based neuronal therapeutic and therapeutic methods A method of stimulating neuronal growth or repair comprising exposing a target neuron or neuronal area to a solution of the metallothionein isoform MT-IIA.
US08691764B2	Inhibitors of NF-κB activity The present invention provides a method for inhibiting NF-κB activity in a subject, the method comprising providing an agent capable of inducing expression of annexin 1, whereby said agent induces expression of annexin 1 and whereby said induced expression of annexin 1 inhibits NF-κB activity. Also provided are annexin 1 mimetics capable of binding to NF-κB and pharmaceutical compositions of such inducing and mimetic agents.
US08691763B2	Methods for treating or preventing cardiovascular disorders and providing cardiovascular protection The present invention provides methods for treating, preventing and/or ameliorating at least one cardiovascular disorder in a human in need thereof comprising administering to said human a pharmaceutical composition comprising at least one polypeptide having at least one GLP-1 activity and/or at least one GLP-1 agonist.
US08691761B2	Somatostatin receptor 2 antagonists The invention is directed to somatostatin analogs which are receptor antagonists of the somatostatin receptor, including receptor-selective antagonists, especially sst2-selective antagonists. Related compounds and compositions are included, including antagonists complexed with or conjugated to radioactive nuclides. The antagonists of the invention are useful in diagnosing and treating neoplastic and non-neoplastic mammalian diseases; such methods, and kits, are encompassed.
US08691758B2	Inhibitors of serine proteases, particularly HCV NS3-NS4A protease The present invention relates to compounds of formula I or formula Ia or pharmaceutically acceptable salts thereof, that inhibit serine protease activity, particularly the activity of hepatitis C virus NS3-NS4A protease. As such, they act by interfering with the life cycle of the hepatitis C virus and are useful as antiviral agents. The invention further relates to pharmaceutically acceptable compositions comprising said compounds either for ex vivo use or for administration to a patient suffering from HCV infection and processes for preparing the compounds. The invention also relates to methods of treating an HCV infection in a patient by administering a pharmaceutical composition comprising a compound of this invention.
US08691757B2	Hepatitis C virus inhibitors Hepatitis C virus inhibitors having the general formula (I) are disclosed. Compositions comprising the compounds and methods for using the compounds to inhibit HCV are also disclosed.
US08691754B2	Microparticles with enhanced covalent binding capacity and their uses A polyelectrolyte having multiple exposed functional groups, each such group being capable of covalently bonding to a molecule, is immobilized on a surface for the purpose of bonding to a biomolecule. The biomolecule can be, for example, a nucleic acid, e.g., an amine functionalized oligonucleotide. The polyelectrolyte can include, e.g., BSA (Bovine Serum Albumin) which is bound to a functionalized surface using a covalent immobilization strategy, e.g., reaction with the surface of a tosyl-activated microparticle. Following such reaction, exposed reactive functional groups on the protein, such as amine, carboxyl, thiol, hydroxyl groups can further be utilized to covalently couple the oligonucleotide of interest using suitable chemistry.
US08691753B2	Pseudodipeptides as MMP inhibitors The invention relates to compounds, in particular MMP inhibitors. The compounds of the invention have formula (1). The invention can be used in particular in the pharmaceutical field. The present invention also relates to labeled compounds of formula (2), and to the use thereof as contrast agents for detecting extracellular matrix metalloproteinases.
US08691751B2	Compounds containing a vascular disrupting agent The present invention relates to compounds, and pharmaceutically acceptable salts thereof, comprising a vascular disrupting agent (VDA) associated and a MMP proteolytic cleavage site. The compounds are useful in the treatment of cancer.
US08691746B2	Cyclohexene derivatives and their use as odorants The present invention relates to a process for the production of formyl cyclohexene derivatives which are suitable as odorants as such or as intermediates for the preparation of further odorants. In particular the present invention relates to a domino-methylenation-Diels-Alder reaction of α,β-unsaturated aldehydes using formaldehyde in the presence of 1,3-butadienes.
US08691743B2	Liquid detergent compositions The present invention relates to aqueous liquid detergent compositions comprising an alkaline protease and/or one or more other non-proteolytic enzymes, and an enzyme stabilization system. The invention also relates to enhancing stability of the non-proteolytic enzymes in a liquid detergent composition comprising an alkaline protease.
US08691734B2	Method of fracturing with phenothiazine stabilizer Well treatment fluids and methods of treating high temperature subterranean formations of up to about 500° F. (260° C.) are provided. The well treatment fluids and methods utilize a high molecular weight synthetic copolymer and a pH buffer than maintains a pH in a range of about 4.5 to about 5.25 for the fluids. The high molecular weight synthetic copolymer is derived from acrylamide, acrylamidomethylpropanesulfonic acid, and vinyl phosphonates. The well treatment fluids may be energized or foamed.
US08691731B2	Heat generation process for treating oilfield deposits Generating heat within a combination solvent/acid system removes undesirable deposits from petroleum reservoir formations (especially the near well-bore region), oilfield equipment, and petroleum processing equipment. An exothermic reaction occurs between the solvent and the acid and the heat evolved helps remove organic solid deposits. The acids may include organic acid compounds, such as sulfonic acids, sulfuric acid and nitric acid. The solvents may include terpene- and terpene-derivative-containing solvents, including, but not necessarily limited to, limonene, pinene, dipentene, myrcene, turpentines and compounds having at least one double bond, such as methyl furan, dienes, styrene, vinyl acetate and the like. The exothermic reaction produces a great amount of heat, and together with using certain acids and solvents already known as effective to remove paraffin and asphaltene deposition, removing such deposits is improved.
US08691726B2	Synergistic combination of a glyphosate compound and ZPT A synergistic antimicrobial composition containing a glyphosate compound and zinc pyrithione is provided. Also provided is a method of inhibiting the growth of or controlling the growth of microorganisms in a building material by adding such a synergistic antimicrobial composition. Also provided is a coating composition containing such a synergistic antimicrobial composition, and a dry film made from such a coating composition.
US08691722B2	Sorbent comprising activated carbon particles, sulfur and metal catalyst Sorbents comprising activated carbon particles, sulfur, and metal catalyst. The sorbents may be used, for example, for the removal of a contaminant, such as mercury, from a fluid stream.
US08691717B2	Core/shell-type catalyst particles and methods for their preparation The invention discloses core/shell, type catalyst particles comprising a Mcore/Mshell structure with Mcore=inner particle core and Mshell=outer particle shell, wherein the medium diameter of the catalyst particle (dcore+shell) is in the range of 20 to 100 nm, preferably in the range of 20 to 50 nm. The thickness of the outer shell (tshell) is about 5 to 20% of the diameter of the inner particle core of said catalyst particle, preferably comprising at least 3 atomic layers. The core/shell type catalyst particles, particularly the particles comprising a Pt˜based shell reveal a high specific activity. The catalyst particles are preferably supported on suitable support materials such as carbon black and are used as electrocatalysts for fuel cells.
US08691714B2	Processes for making multimodal molecular weight distribution polyolefins This invention relates to a process to make a multimodal polyolefin composition comprising: (i) contacting at least one first olefin monomer with a mixed catalyst system, under polymerization conditions, to produce at least a first polyolefin component having a Mw of 5,000 g/mol to 600,000 g/mol, wherein the mixed catalyst system comprises: (a) at least one polymerization catalyst comprising a Group 4 or Group 5 transition metal; (b) at least one organochromium polymerization catalyst; (c) an activator; and (d) a support material; (ii) thereafter, contacting the first polyolefin component/mixed catalyst system combination with a molecular switch; (iii) contacting the first polyolefin component/mixed catalyst system combination with at least one second olefin monomer, which may be the same or different, under polymerization conditions; and (iv) obtaining a multimodal polyolefin composition.
US08691709B2	Method of forming metal carbide barrier layers for fluorocarbon films A method of forming metal carbide barrier layers for fluorocarbon films in semiconductor devices is described. The method includes depositing a fluorocarbon film on a substrate and depositing a metal-containing layer on the fluorocarbon film at a first temperature, where the metal-containing layer reacts with the fluorocarbon film to form a metal fluoride layer at an interface between the metal-containing layer and the fluorocarbon film. The method further includes heat-treating the metal-containing layer at a second temperature that is greater than the first temperature, wherein the heat-treating the metal-containing layer removes fluorine from the metal fluoride layer by diffusion through the metal-containing layer and forms a metal carbide barrier layer at the interface between the metal-containing layer and the fluorocarbon film, and wherein the metal-containing layer survives the heat-treating at the second temperature without blistering or pealing.
US08691704B2	Methods for forming semiconductor constructions, and methods for selectively etching silicon nitride relative to conductive material The invention includes methods for selectively etching insulative material supports relative to conductive material. The invention can include methods for selectively etching silicon nitride relative to metal nitride. The metal nitride can be in the form of containers over a semiconductor substrate, with such containers having upwardly-extending openings with lateral widths of less than or equal to about 4000 angstroms; and the silicon nitride can be in the form of a layer extending between the containers. The selective etching can comprise exposure of at least some of the silicon nitride and the containers to Cl2 to remove the exposed silicon nitride, while not removing at least the majority of the metal nitride from the containers. In subsequent processing, the containers can be incorporated into capacitors.
US08691701B2	Strip with reduced low-K dielectric damage A method for forming etched features in a low-k dielectric layer disposed below the photoresist mask in a plasma processing chamber is provided. Features are etched into the low-k dielectric layer through the photoresist mask. The photoresist mask is stripped, wherein the stripping comprising at least one cycle, wherein each cycle comprises a fluorocarbon stripping phase, comprising flowing a fluorocarbon stripping gas into the plasma processing chamber, forming a plasma from the fluorocarbon stripping gas, and stopping the flow of the fluorocarbon stripping gas into the plasma processing chamber and a reduced fluorocarbon stripping phase, comprising flowing a reduced fluorocarbon stripping gas that has a lower fluorocarbon flow rate than the fluorocarbon stripping gas into the plasma processing chamber, forming the plasma from the reduced fluorocarbon stripping gas, and stopping the flow of the reduced fluorocarbon stripping gas.
US08691699B2	Manufacturing method of semiconductor device and semiconductor device A manufacturing method of a semiconductor device includes: forming an insulating layer above a substrate; forming a recessed section in the insulating layer; forming, on the insulating layer, a mask pattern having a first opening which exposes the recessed section, and a second opening which is arranged outside the first opening and does not expose the recessed section; forming a first conductive member and a second conductive member by respectively depositing a conductive material in the first opening and the second opening; and polishing and removing the first conductive member and the second conductive member on the upper side of the insulating layer so as to leave the first conductive member in the recessed section.
US08691698B2	Controlled gas mixing for smooth sidewall rapid alternating etch process A method for etching features in a silicon layer disposed below a mask in a plasma processing chamber a plurality of cycles is provided. A deposition phase forming a deposition on the silicon layer in the plasma processing chamber is provided comprising providing a deposition gas into the plasma processing chamber wherein the deposition gas comprises a halogen containing etchant component and a fluorocarbon deposition component, forming the deposition gas into a plasma, which provides a net deposition on the silicon layer, and stopping the flow of the deposition gas. A silicon etch phase is provided, comprising providing a silicon etch gas into the plasma processing chamber that is different than the deposition gas, forming the silicon etch gas into a plasma to etch the silicon layer, and stopping the flow of the silicon etch gas.
US08691696B2	Methods for forming an integrated circuit with straightened recess profile Methods are provided for forming an integrated circuit. In an embodiment, the method includes forming a sacrificial mandrel overlying a base substrate. Sidewall spacers are formed adjacent sidewalls of the sacrificial mandrel. The sidewall spacers have a lower portion that is proximal to the base substrate, and the lower portion has a substantially perpendicular outer surface relative to the base substrate. The sidewall spacers also have an upper portion that is spaced from the base substrate. The upper portion has a sloped outer surface. A first dielectric layer is formed overlying the base substrate and is conformal to at least a portion of the upper portion of the sidewall spacers. The upper portion of the sidewall spacers is removed after forming the first dielectric layer to form a recess having a re-entrant profile in the first dielectric layer. The re-entrant profile of the recess is straightened.
US08691695B2	CMP compositions and methods for suppressing polysilicon removal rates The present invention provides a chemical-mechanical polishing (CMP) composition suitable for polishing a silicon nitride-containing substrate while suppressing polysilicon removal from the substrate. The composition comprises abrasive particles suspended in an acidic aqueous carrier containing a surfactant comprising an alkyne-diol, an alkyne diol ethoxylate, or a combination thereof. Methods of polishing a semiconductor substrate therewith are also disclosed.
US08691694B2	Solderless back contact solar cell module assembly process In order to better and more efficiently assemble back contact solar cells into modules, the cell to cell soldering and other soldered connections are replaced by electro and/or electroless plating. Back contact solar cells, diodes and external leads can be first laminated to the module front glass for support and stability. Conductive materials are deposited selectively to create a plating seed pattern for the entire module circuit. Subsequent plating steps create an integrated cell and module metallization. This avoids stringing and tabbing and the associated soldering steps. This process is easier for mass manufacturing and is advantageous for handling fragile silicon solar cells. Additionally, since highly corrosion resistant metals can be plated, the moisture barrier requirements of the back side materials can be greatly relaxed. This can simplify and reduce the cost of the back side of the module.
US08691692B2	Semiconductor chips and methods of forming the same Provided are a semiconductor chip and a method of manufacturing the same. The semiconductor chip includes a substrate having a first side and a second side facing each other, and a through electrode being disposed in a hole penetrating the substrate, wherein an opening surrounded by the through electrode is disposed in the hole, wherein the opening comprises a first end adjacent to the first side of the substrate and a second end adjacent to the second side of the substrate.
US08691684B2	Layout and pad floor plan of power transistor for good performance of SPU and STOG A power transistor for use in an audio application is laid out to minimize hot spots. Hot spots are created by non-uniform power dissipation or overly concentrated current densities. The source and drain pads are disposed relative to each other to facilitate uniform power dissipation. Interleaving metal fingers and upper metal layers are connected directly to lower metal layers in the absence of vias to improve current density distribution. This layout improves some fail detection tests by 17%.
US08691680B2	Method for fabricating memory device with buried digit lines and buried word lines A method for fabricating a memory array includes providing a semiconductor substrate having thereon a plurality of line-shaped active areas and intermittent line-shaped trench isolation regions between the plurality of line-shaped active areas, which extend along a first direction; forming buried word lines extending along a second direction in the semiconductor substrate, the buried word lines intersecting with the line-shaped active areas and the intermittent line-shaped trench isolation regions, wherein the second direction is not perpendicular to the first direction; forming buried digit lines extending along a third direction in the semiconductor substrate, wherein the third direction is substantially perpendicular to the second direction; and forming storage nodes at storage node sites between the buried digit lines.
US08691679B2	Semiconductor device and method of manufacturing the same A silicon carbide substrate has a substrate surface. A gate insulating film is provided to cover a part of the substrate surface. A gate electrode covers a part of the gate insulating film. A contact electrode is provided on the substrate surface, adjacent to and in contact with the gate insulating film, and it contains an alloy having Al atoms. Al atoms do not diffuse from the contact electrode into a portion of the gate insulating film lying between the substrate surface and the gate electrode. Thus, in a case where a contact electrode having Al atoms is employed, reliability of the gate insulating film of a semiconductor device can be improved.
US08691677B2	Method for boron doping silicon wafers The object of the invention is a process for P-type boron doping of silicon wafers placed on a support in the chamber of a furnace of which one end comprises a wall in which means for introducing reactive gases and a gas carrying a boron precursor in gaseous form are located, whereby said process comprises the stages that consist in: a) In the chamber, reacting the reactive gases with boron trichloride BCl3 that is diluted in the carrier gas at a pressure of between 1 kPa and 30 kPa, and a temperature of between 800° C. and 1100° C., for forming a boron oxide B2O3 glass layer, b) Carrying out the diffusion of atomic boron in silicon under an N2+O2 atmosphere at a pressure of between 1 kPa and 30 kPa. A furnace designed for the implementation of said doping process as well as its applications—the manufacturing of large boron-doped silicon slices, in particular for photovoltaic applications—is also claimed.
US08691675B2	Vapor phase deposition processes for doping silicon A process of doping a silicon layer with dopant atoms generally includes reacting a vapor of a dopant precursor with oxide and/or hydroxide reactive sites present on the silicon layer to form a self assembled monolayer of dopant precursor; hydrolyzing the self assembled monolayer of the dopant precursor with water vapor to form pendant hydroxyl groups on the dopant precursor; capping the self assembled monolayer with an oxide layer; and annealing the silicon layer at a temperature effective to diffuse dopant atoms from the dopant precursor into the silicon layer. Additional monolayers can be formed in a similar manner, thereby providing controlled layer-by-layer vapor phase deposition of the dopant precursor compounds for controlled doping of silicon.
US08691674B2	Method for producing group 3-5 nitride semiconductor and method for producing light-emitting device A method for producing a group 3-5 nitride semiconductor includes the steps of (i), (ii), (iii) in this order: (i) placing inorganic particles on a substrate, (ii) epitaxially growing a semiconductor layer by using the inorganic particles as a mask, and (iii) separating the substrate and the semiconductor layer by irradiating the interface between the substrate and the semiconductor layer with light; and a method for producing a light emitting device further includes adding electrodes.
US08691671B2	Planar nonpolar group-III nitride films grown on miscut substrates A nonpolar III-nitride film grown on a miscut angle of a substrate, in order to suppress the surface undulations, is provided. The surface morphology of the film is improved with a miscut angle towards an α-axis direction comprising a 0.15° or greater miscut angle towards the α-axis direction and a less than 30° miscut angle towards the α-axis direction.
US08691667B1	Method and apparatus for depositing a pattern on a substrate This invention relates to a process for forming a continuous pattern on a substrate with a liquid media. Upon the deposition of the liquid media on the substrate, a portion the continuous pattern is evaporated upon contact with the substrate.
US08691661B2	Trench with reduced silicon loss An isolation trench in a substrate of a semiconductor device includes a first shallow portion, a transition region, and a second deeper portion. The isolation trench contains a dielectric filler. The isolation trench is formed by first forming a first shallow portion of the isolation trench, forming polysilicon sidewalls on the first shallow portion, and then etching the second deeper portion.
US08691660B2	Semiconductor component with trench isolation and corresponding production method The invention relates to a semiconductor component with trench isolation and to an associated fabrication method, a trench isolation (STI, TTI) having a deep isolation trench with a covering insulation layer (10, 11), a side wall insulation layer (6) and an electrically conductive filling layer (7), which is electrically connected to a predetermined doping region (1) of the semiconductor substrate in a bottom region of the trench. The use of a trench contact (DTC), which has a deep contact trench with a side wall insulation layer (6) and an electrically conductive filling layer (7), which is likewise electrically connected to the predetermined doping region (1) of the semiconductor substrate in a bottom region of the contact trench, makes it possible to improve the electrical shielding properties with a reduced area requirement.
US08691655B2	Method of semiconductor integrated circuit fabrication A method of fabricating a semiconductor integrated circuit (IC) is disclosed. The method includes receiving a semiconductor device, patterning a first hard mask to form a first recess in a high-resistor (Hi-R) stack, removing the first hard mask, forming a second recess in the Hi-R stack, forming a second hard mask in the second recess in the Hi-R stack. A HR can then be formed in the semiconductor substrate by the second hard mask and a gate trench etch.
US08691653B2	Semiconductor structure with reduced surface field effect and manufacturing process thereof A semiconductor structure and a manufacturing process thereof are disclosed. The semiconductor structure includes a substrate having a first conductive type, a first well having a second conductive type formed in the substrate, a doped region having the second conductive type formed in the first well, a field oxide and a second well having the first conductive type. The doped region has a first net dopant concentration. The field oxide is formed on a surface area of the first well. The second well is disposed underneath the field oxide and connected to a side of the doped region. The second well has a second net dopant concentration smaller than the first net dopant concentration.
US08691650B2	MOSFET with recessed channel film and abrupt junctions MOSFETs and methods for making MOSFETs with a recessed channel and abrupt junctions are disclosed. The method includes creating source and drain extensions while a dummy gate is in place. The source/drain extensions create a diffuse junction with the silicon substrate. The method continues by removing the dummy gate and etching a recess in the silicon substrate. The recess intersects at least a portion of the source and drain junction. Then a channel is formed by growing a silicon film to at least partially fill the recess. The channel has sharp junctions with the source and drains, while the unetched silicon remaining below the channel has diffuse junctions with the source and drain. Thus, a MOSFET with two junction regions, sharp and diffuse, in the same transistor can be created.
US08691649B2	Methods of forming recessed channel array transistors and methods of manufacturing semiconductor devices In methods of manufacturing a recessed channel array transistor, a recess may be formed in an active region of a substrate. A plasma oxidation process may be performed on the substrate to form a preliminary gate oxide layer on an inner surface of the recess and an upper surface of the substrate. Moistures may be absorbed in a surface of the preliminary gate oxide layer to form a gate oxide layer. A gate electrode may be formed on the gate oxide layer to fill up the recess. Source/drain regions may be formed in an upper surface of the substrate at both sides of the gate electrode. Thus, the oxide layer may have a uniform thickness distribution and a dense structure.
US08691643B2	Methods of forming semiconductor devices Methods of forming semiconductor devices are provided. The methods may include forming a gate pattern on an active region of a substrate. The methods may further include performing a deoxidization treatment on the substrate.
US08691642B2	Method of fabricating semiconductor device including forming epitaxial blocking layers by nitridation process A method of fabricating a semiconductor device includes forming gate structures on PMOS and NMOS transistor regions of the semiconductor substrate, forming epitaxial blocking layers on source/drain regions of PMOS and NMOS transistor regions using a nitridation process, then selectively removing one of the epitaxial blocking layers, and using a SEG process to form an epitaxial layer on respective source/drain regions while shielding the other source/drain regions with a remaining epitaxial blocking layer.
US08691638B2	High-K metal gate device A method of forming a semiconductor device is presented. The method includes providing a substrate. The method further includes forming a gate stack having a gate electrode on the substrate, which includes forming a metal gate electrode layer. A buffer gate electrode layer is formed on top of the metal gate electrode layer and a top gate electrode layer having a poly-silicon alloy is formed over the metal gate electrode layer.
US08691636B2	Method for removing germanium suboxide A method for removing germanium suboxide between a germanium (Ge) substrate and a dielectric layer made of metal oxide includes causing a supercritical fluid composition that includes a supercritical carbon dioxide fluid and an oxidant to diffuse into the germanium suboxide such that metal residues in the dielectric layer, the germanium suboxide and the oxidant are subjected to a redox reaction so as to reduce the germanium suboxide into germanium.
US08691631B2	Device including two mounting surfaces A device including two mounting surfaces. One embodiment provides a power semiconductor chip and having a first electrode on a first surface and a second electrode on a second surface opposite to the first surface. A first external contact element and a second external contact element, are both electrically coupled to the first electrode of the semiconductor chip. A third external contact element and a fourth external contact element, both electrically coupled to the second electrode of the semiconductor chip. A first mounting surface is provided on which the first and third external contact elements are disposed. A second mounting surface is provided on which the second and fourth external contact elements are disposed.
US08691630B2	Semiconductor package structure and manufacturing method thereof A method of manufacturing a semiconductor package structure is provided. A heat-conductive block is adhered to a portion of a second surface of a conductive substrate via a first adhesive layer. An opening is formed by performing a half-etching process on a first surface of the conductive substrate. The remaining conductive substrate is patterned to form leads and expose a portion of the heat-conductive block. Each lead has a first portion and a second portion. A thickness of the first portion is greater than a thickness of the second portion. A first lower surface of the first portion and a second lower surface of the second portion are coplanar. A chip is disposed on the exposed portion of the heat-conductive block and electrically connected to the second portions of the leads. A first bottom surface of the heat-conductive block and a second bottom surface of a molding compound are coplanar.
US08691626B2	Semiconductor chip device with underfill A method of manufacturing is provided that includes placing a removable cover on a surface of a substrate. The substrate includes a first semiconductor chip positioned on the surface. The first semiconductor chip includes a first sidewall. The removable cover includes a second sidewall positioned opposite the first sidewall. A first underfill is placed between the first semiconductor chip and the surface wherein the second sidewall provides a barrier to flow of the first underfill. Various apparatus are also disclosed.
US08691625B2	Method for making a chip package The present invention relates to a method for making a chip package. The method includes the following steps: (a) providing a substrate having at least one conductive via; (b) disposing the substrate on a carrier; (c) removing part of the substrate, so as to expose the conductive via, and form at least one through via; (d) disposing a plurality of chips on a surface of the substrate, wherein the chips are electrically connected to the through via of the substrate; (e) forming an encapsulation; (f) removing the carrier; (g) conducting a flip-chip mounting process; (h) removing the encapsulation; and (i) forming a protective material. Whereby, the carrier and the encapsulation can avoid warpage of the substrate during the manufacturing process.
US08691623B2	Semiconductor device and manufacturing method thereof An object is to provide a semiconductor device of which a manufacturing process is not complicated and by which cost can be suppressed, by forming a thin film transistor using an oxide semiconductor film typified by zinc oxide, and a manufacturing method thereof. For the semiconductor device, a gate electrode is formed over a substrate; a gate insulating film is formed covering the gate electrode; an oxide semiconductor film is formed over the gate insulating film; and a first conductive film and a second conductive film are formed over the oxide semiconductor film. The oxide semiconductor film has at least a crystallized region in a channel region.
US08691621B1	Thiol bond formation concurrent with silver nanoparticle ink thermal treatment A method is provided for preparing a printed metal surface for the deposition of an organic semiconductor material. The method provides a substrate with a top surface, and a metal layer is formed overlying the substrate top surface. Simultaneous with a thermal treatment of the metal layer, the metal layer is exposed to a gaseous atmosphere with thiol molecules. In response to exposing the metal layer to the gaseous atmosphere with thiol molecules, the work function of the metal layer is increased. Subsequent to the thermal treatment, an organic semiconductor material is deposited overlying the metal layer. In one aspect, the metal layer is exposed to the gaseous atmosphere with thiol molecules by evaporating a liquid containing thiol molecules in an ambient air atmosphere. Alternatively, a delivery gas is passed through a liquid containing thiol molecules. An organic thin-film transistor (OTFT) and OTFT fabrication process are also provided.
US08691616B2	Method for manufacturing thin film solar cell A method for manufacturing a thin film solar cell includes depositing a front electrode on a substrate in a chamber, etching the front electrode formed on the substrate to form an uneven portion on the surface of the front electrode, forming a photoelectric conversion unit on the front electrode, and forming a back electrode on the photoelectric conversion unit. The depositing of the front electrode includes depositing the front electrode while reducing a process pressure of the chamber from a first pressure to a second pressure lower than the first pressure. The etching of the front electrode form the uneven portion of the front electrode so that a top portion of the uneven portion includes a portion formed at the second pressure.
US08691615B2	Image sensor and method of manufacturing the same An image sensor and a method of manufacturing the same. The image sensor includes a plurality of photoelectric conversion units that are horizontally arranged and selectively emit electric signals by absorbing color beams.
US08691613B2	Method for manufacturing photoelectric conversion device A crystalline-based silicon photoelectric conversion device comprises: an intrinsic silicon-based layer and a silicon-based layer of a first conductivity type, on one surface of a single-crystal silicon substrate of the first conductivity type; and an intrinsic silicon-based and a silicon-based layer of an opposite conductivity type, in this order on the other surface of the silicon substrate. At least one of forming the intrinsic silicon-based layer of the first conductivity type layer-side forming the intrinsic silicon-based layer of the opposite conductivity type layer-side includes: forming a first intrinsic silicon-based thin-film layer having a thickness of 1-10 nm on the silicon substrate; plasma-treating the silicon substrate in a gas containing mainly hydrogen; and forming a second intrinsic silicon-based thin-film layer on the first intrinsic silicon-based thin-film.
US08691611B2	Method for creating a micromechanical membrane structure and MEMS component In a method for manufacturing a micromechanical membrane structure, a doped area is created in the front side of a silicon substrate, the depth of which doped area corresponds to the intended membrane thickness, and the lateral extent of which doped area covers at least the intended membrane surface area. In addition, in a DRIE (deep reactive ion etching) process applied to the back side of the silicon substrate, a cavity is created beneath the doped area, which DRIE process is aborted before the cavity reaches the doped area. The cavity is then deepened in a KOH etching process in which the doped substrate area functions as an etch stop, so that the doped substrate area remains as a basic membrane over the cavity.
US08691606B2	Method for manufacturing a light emitting diode with smooth surface for reflective electrode A light emitting diode comprising an epitaxial layer structure, a first electrode, and a second electrode. The first and second electrodes are separately disposed on the epitaxial layer structure, and the epitaxial layer structure has a root-means-square (RMS) roughness less than about 3 at a surface whereon the first electrode is formed.
US08691603B2	Organic el device manufacturing method, organic el device, and electronic apparatus having a luminescent layer disposed over another luminescent layer In a method for manufacturing an organic EL device, a first luminescent layer emitting first color light is formed over a first anode disposed on a substrate by coating. A second luminescent layer emitting second color light is formed over a second anode disposed on the substrate. An intermediate layer having electron injection performance is formed on the first luminescent layer and the second luminescent layer. A third luminescent layer emitting third color light is formed over the intermediate layer and a third anode disposed on the substrate by vapor deposition. A cathode is formed on the third luminescent layer.
US08691601B2	Semiconductor device and penetrating electrode testing method Disclosed herein is a semiconductor device, including: a semiconductor substrate; an integrated circuit formed on a first main surface of the semiconductor substrate; a penetrating electrode that penetrates the semiconductor substrate in the thickness direction and has its one end electrically connected to the integrated circuit; a bump electrode formed on a second main surface of the semiconductor substrate and electrically connected to another end of the penetrating electrode; and a test pad electrode formed on the second main surface of the semiconductor substrate and electrically connected to the bump electrode.
US08691599B2	Parameter extraction method for semiconductor device A parameter extraction method for semiconductor devices includes: providing a first multi-finger device and a second multi-finger device, wherein the gate-finger numbers between the first and second multi-finger devices are different; performing an open de-embedding, then the high-frequency test apparatus measuring a first intrinsic gate capacitance of the first multi-finger device and a second intrinsic gate capacitance of the second multi-finger device; calculating a slope according to the first and second intrinsic gate capacitances, and the first and second gate-finger numbers; performing a 3D capacitance simulation for computing the poly finger-end fringing capacitances; utilizing a long channel device for measuring the gate capacitance and extracting the intrinsic gate capacitance, then calculating an inversion channel capacitance per unit area; and computing a delta channel width of the semiconductor device, according to the slope, the poly finger-end fringing capacitance, and the inversion channel capacitance per unit area.
US08691598B1	Dual-loop control for laser annealing of semiconductor wafers Systems and methods for performing semiconductor laser annealing using dual loop control are disclosed. The first control loop operates at a first frequency and controls the output of the laser and controls the 1/f laser noise. The second control loop also controls the amount of output power in the laser and operates at second frequency lower than the first frequency. The second control loop measures the thermal emission of the wafer over an area the size of one or more die so that within-die emissivity variations are average out when determining the measured annealing temperature. The measured annealing temperature and an annealing temperature set point are used to generate the control signal for the second control loop.
US08691597B2	Method for manufacturing a semiconductor device including application of a plating voltage An automatic analyzer detects voltage applied across electrodes, and judges whether voltage value falls within set voltage range. When the detected voltage value is lower than minimum value of set voltage range, the analyzer calculates the deficient amount of base solution based on the detected voltage value, controls a valve to supply the deficient amount of base solution, then, performs operation control of the valve so as to keep the prescribed amount of plating solution in plating solution tank, and discharges plating solution. When the detected voltage value is higher than maximum value of set voltage range, the analyzer calculates the excess amount of base solution based on the detected voltage value, controls a valve, and supplies pure water into the tank so that the base solution concentration falls within prescribed range to dilute plating solution, then controls a valve, and discharges plating solution so as to keep prescribed amount.
US08691589B2	Method for detecting formation of G-quadruplex The method of the present disclosure determines whether a target DNA forms a G-quadruplex using a phenomenon in which thioflavin T generates a strong fluorescence when reacted with the G-quadruplex in the presence of potassium ions.
US08691587B2	Use of SFRP-3 in the assessment of heart failure Disclosed is a method for assessing heart failure in vitro including the steps of measuring in a sample the concentration of the marker SFRP-3, of optionally measuring in the sample the concentration of one or more other marker(s) of heart failure, and of assessing heart failure by comparing the concentration determined in for SFRP-3 and the concentration(s) determined for the optionally one or more other marker to the concentration of this marker or these markers as established in a reference population. Also disclosed are the use of SFRP-3 as a marker protein in the assessment of heart failure, a marker combination comprising SFRP-3 and a kit for measuring SFRP-3.
US08691584B2	Sperm processing methods A method of analyzing particles in a fluid stream including focusing a generally elliptical beam spot to a width less than the size of the particles. As particles pass through the beam spot electromagnetic radiation from the particles which is then detected and converted into electrical signals indicative of characteristics of the particles. The electrical signals may be digitally sampled to provide digital information which may be analyzed to extract information and to classify the particles.
US08691582B2	Methods and systems for fluid examination and remediation A method for in situ monitoring within a specified environment. The method includes locating a housing in a well, wherein a set of pumps and a plurality of test beds are inserted. Each of the set of pumps are controlled by signals from the control system to push water from each pump into one of the plurality of separate test beds where, after flowing through each of the test beds, effluent flows into an effluent storage device.
US08691578B2	Method for generating homoplasmic cells from heteroplasmic cells A method includes providing a eukaryotic cell including mutant mtDNA in which there is at least one mutation in the mtDNA, allowing the cell to come into contact with an active oxygen species or a chemical species that generates such an active oxygen species in the cell (e.g., hydrogen peroxide) and thereby changing the percentage of mutant mtDNA (mitochondrial genomic DNA) in the cell as a result of the contact. Also featured are cells obtained by the above-described method.
US08691577B2	Somatic embryogenesis of Jatropha curcas from ovules The present invention relates to the field of somatic embryo production, particularly to methods for somatic embyrogenesis of Jatropha from ovules. More specifically, the present invention relates to a method and media compositions for somatic embryogenesis of Jatropha curcas from ovules of unopened flower buds. The method is well suited for Jatropha curcas transformation, for producing clonal planting stock useful for large scale Jatropha curcas plantation and for producing haploids, double haploids, diploids and disease-free plantlets.
US08691572B2	Diagnosing, monitoring and treating inflammation The present invention provides methods and compositions for treating chronic inflammatory disease in a subject and associated pharmaceutical compositions, medical devices and systems.
US08691566B1	Cells useful for immuno-based botulinum toxin serotype a activity assays The present specification discloses clonal cell lines susceptible to BoNT/A intoxication, methods of producing such clonal cell lines, and methods of detecting Botulinum toxin serotype A activity using such clonal cell lines.
US08691565B2	Method of reseeding adherent cells grown in a hollow fiber bioreactor system This invention is directed to methods of directly reseeding harvested adherent cells grown in a hollow fiber bioreactor. Also disclosed is a novel harvest media for use in directly reseeding adherent cells into a hollow fiber bioreactor.
US08691555B2	Production of carotenoids in oleaginous yeast and fungi The present invention provides systems for producing engineered oleaginous yeast or fungi that express carotenoids.
US08691552B2	Microaerobic cultures for converting glycerol to chemicals Glycerol or other reduced carbon sources may be used as a feedstock for the microbial production of chemical products under certain microaerobic conditions. For example, such production may occur under microaerobic or microrespiratory conditions in which electron acceptors are consumed in the reaction as quickly as they are added. In such reactions, the reaction product is at least as reduced as carbon source. Further, during such a reaction, at least some of the carbon source is used to generate cell mass. In addition, microorganisms with modified genomes are provided for carrying out the methods herein.
US08691550B2	Vaccines against japanese encephalitis virus and west nile virus The invention provides attenuated Flavivirus vaccines, such as vaccines against Japanese encephalitis virus and West Nile virus, as well as methods of making and using these vaccines.
US08691549B2	High fidelity restriction endonucleases Compositions and methods are provided for enzymes with altered properties that involve a systematic approach to mutagenesis and a screening assay that permits selection of the desired proteins. Embodiments of the method are particularly suited for modifying specific properties of restriction endonucleases such as star activity. The compositions includes restriction endonucleases with reduced star activity as defined by an overall fidelity index improvement factor.
US08691546B2	Inhibitors of Bruton's tyrosine kinase Disclosed herein are compounds, including compounds having the structure of Formula (A), (B), (C), and (D), as described in further detail herein, that form covalent bonds with Bruton's tyrosine kinase (Btk). Also described are irreversible inhibitors of Btk. Methods for the preparation of the compounds are disclosed. Also disclosed are pharmaceutical compositions that include the compounds. Methods of using the Btk inhibitors are disclosed, alone or in combination with other therapeutic agents, for the treatment of autoimmune diseases or conditions, heteroimmune diseases or conditions, cancer, including lymphoma, and inflammatory diseases or conditions.
US08691543B2	Nanofibrous scaffold comprising immobilized cells The invention is directed to a device and method to prevent migration of Human Mesenchymal Stem Cells (hMSCs) from a delivery site while allowing communication between the stem cells and native cardiomyocytes. The device is characterized by scaffold pore size, fiber diameter and biomaterial selection. The invention includes a two part polyurethane scaffold that prevents migration of stem cells, allows gap junction formation through pores and is packaged for minimally invasive delivery.
US08691542B2	Tissue engineering methods and compositions The presently disclosed subject matter generally relates to methods and systems for facilitating the growth and differentiation of adipose-derived stem cells for laboratory and therapeutic applications. The cells can be employed alone or in conjunction with unique biologically-compatible scaffold structures to generate differentiated tissues and structures, both in vitro and in vivo. The presently disclosed subject matter further relates to methods of forming and using improved tissue engineered scaffolds that can be used as substrates to facilitate the growth and differentiation of cells.
US08691536B2	Pectin lyase, pectin lyase polynucleotide, enzyme preparation, and method for producing single cells of plant tissue To provide a pectin lyase and a gene for a pectin lyase which can be used in an enzyme preparation for processing plant tissue, and which possesses sufficient maceration activity even under highly acidic conditions. Isolation and purification of a pectin lyase and a gene for a pectin lyase having a molecular weight of 39,500 produced by an Aspergillus filamentous fungus, and possessing a maceration activity and a pectin lyase activity. The pectin lyase has a specified amino acid sequence, an optimal pH of 3.5 for maceration activity, an optimal pH of 4.5 for pectin lyase activity, and deactivates with boiling treatment for 15 minutes at 121° C. Sterilizing heat treatment are unnecessary, because the present invention possesses sufficient maceration activity at pH 3.0-4.0, and the resulting pectin lysate possesses a bactericidal activity and a potent antibacterial activity. It is possible to inexpensively mass produce food products which retain water-soluble components within the cell, because physical treatment such as stirring or beating is also unnecessary.
US08691533B2	Inducible gene expression The invention relates to vector constructs for an HIV-specific gene therapy. The expression of transgenes is coupled with an infection of the cell with HIV while the transcription of the transgene is controlled by a transcription control region derived from HIV. In addition, the transgene is improved with regard to RNA stability and expression efficiency by modifying the nucleotide sequence.
US08691531B2	Anti-CD79B antibodies and immunoconjugates and methods of use The present invention is directed to compositions of matter comprising nucleic acids encoding a polypeptide comprising the amino acid sequence of SEQ ID NO: 207 or 208, encoding an anti-CD79b antibody comprising the heavy chain variable domain sequence of SEQ ID NO: 207 and the light chain variable domain sequence of SEQ ID NO: 208, or encoding an anti-CD79b antibody having : (i) a variable light chain comprising a HVR-L1 having the sequence of SEQ ID NO: 194, a HVR-L2 having the sequence of SEQ ID NO: 195, and a HVR-L3 having the sequence of SEQ ID NO: 196 and (ii) a variable light chain comprising a HVR-H1 having the sequence of SEQ ID NO: 202, a HVR-H2 having the sequence of SEQ ID NO: 203, and a HVR-H3 having the sequence of SEQ ID NO: 204, and vectors and host cells thereof.
US08691530B2	Process for obtaining aspart insulin using a Pichia pastoris yeast strain The present invention refers to a method for producing a human insulin analogue with high efficiency and excellent yield, by means of a biotechnological process comprising transformation of a Pichia pastoris yeast strain. In particular, the invention refers to a biotechnological process for obtaining aspart insulin.
US08691529B2	Increasing protein production by increasing ABC50 expression or activity The disclosure provides methods and materials for increasing the expression of a protein of interest such as an antibody by a cell ABC50 expression or activity is increased which increases expression of the protein or antibody of interest. The disclosure also provides methods and materials for increasing the sensitivity of a cell to an endoplasmic reticulum stress agent such as Econazole by decreasing the level of ABC50.
US08691528B2	Cell penetrating peptide According to the present invention, it is possible to provide a novel cell penetrating peptide that transports proteins into cells and/or into nuclei at higher frequency than conventional cell penetrating peptides, and a pharmaceutical containing the peptide.
US08691525B2	Methods of combined bioprocessing and related microorganisms, thermophilic and/or acidophilic enzymes, and nucleic acids encoding said enzymes A genetically modified organism comprising: at least one nucleic acid sequence and/or at least one recombinant nucleic acid isolated from Alicyclobacillus acidocaldarius and encoding a polypeptide involved in at least partially degrading, cleaving, transporting, metabolizing, or removing polysaccharides, cellulose, lignocellulose, hemicellulose, lignin, starch, sugars, sugar oligomers, carbohydrates, complex carbohydrates, chitin, heteroxylans, glycosides, xylan-, glucan-, galactan-, or mannan-decorating groups; and at least one nucleic acid sequence and/or at least one recombinant nucleic acid encoding a polypeptide involved in fermenting sugar molecules to a product. Additionally, enzymatic and/or proteinaceous extracts may be isolated from one or more genetically modified organisms. The extracts are utilized to convert biomass into a product. Further provided are methods of converting biomass into products comprising: placing the genetically modified organism and/or enzymatic extracts thereof in fluid contact with polysaccharides, cellulose, lignocellulose, hemicellulose, lignin, starch, sugars, sugar oligomers, carbohydrates, complex carbohydrates, chitin, heteroxylans, glycosides, and/or xylan-, glucan-, galactan-, or mannan-decorating groups.
US08691524B2	Method for isolating a part of a layer of a biological material A film (14) with a tissue section (10) is placed with the tissue section (10) downward on a microscope slide (18) and the microscope slide (18) positioned in the object plane of an inverse microscope; where an adhesive tape (20) is arranged, with a bonding agent (22) downward, above the film (14) and therefore above the tissue section (10); wherein the next step, tissue (36) to be isolated is excised by a focused laser beam, which also divides the film (14); whereupon removal of the adhesive tape (20) from the microscope, the excised tissue pieces (36) adhere to the adhesive tape (20), and the remnant of the film (14) and of the tissue section (10) remains adhering to the microscope slide (18).
US08691515B2	Methods for early detection of blood disorders Disclosed herein are methods of detecting blood disorders, such as diabetes. In particular examples the method includes contacting a blood sample with an amine reagent, blocking an excess of the amine reagent with a blocking reagent, digesting the modified blood sample with trypsin to produce a digested blood sample containing a plurality of glycated N-terminal peptides and non-glycated N-terminal peptides, then analyzing the digested blood sample with MALDI MS. Also provided are reagents for use in such methods.
US08691511B2	Hydroxylated 1,2,4-oxadiazole benzoic acid compounds, compositions thereof and their use in bioassays Novel hydroxylated 1,2,4-oxadiazole benzoic acid compounds, methods of using and pharmaceutical compositions comprising a hydroxylated 1,2,4-oxadiazole benzoic acid derivative are disclosed. The methods include methods of treating or preventing a disease ameliorated by modulation of premature translation termination or nonsense-mediated mRNA decay, or ameliorating one or more symptoms associated therewith.
US08691509B2	Multi-primer amplification method for barcoding of target nucleic acids In certain embodiments, the invention provides amplification methods in which nucleotide tag(s) and a barcode nucleotide sequence are added to target nucleotide sequences. In other embodiments, the present invention provides a microfluidic device that includes a plurality of first input lines and a plurality of second input lines. The microfluidic device also includes a plurality of sets of first chambers and a plurality of sets of second chambers. Each set of first chambers is in fluid communication with one of the plurality of first input lines. Each set of second chambers is in fluid communication with one of the plurality of second input lines. The microfluidic device further includes a plurality of first pump elements in fluid communication with a first portion of the plurality of second input lines and a plurality of second pump elements in fluid communication with a second portion of the plurality of second input lines.
US08691505B2	Promoter for use in transformation of algae The problem to be solved by the present invention is to provide a highly-efficient transformation technology, specifically, a highly-efficient promoter used for transforming algae, a vector comprising the promoter, and a method for transforming algae by using the vector. The promoter according to the present invention is characterized in comprising a polynucleotide constituting a non-coding region located upstream of a gene encoding a structural protein of a ClorDNA virus, and the like.
US08691504B2	Method for detecting variations in nucleic acid sequences The present invention relates to a method and a kit for detecting nucleic acid sequence variation using melting curve analysis, especially relates to a method and a kit for detecting nucleic acid sequence variation by melting curve analysis using self-quenched probe. Said method provides the characteristics of the self-quenched probe employed, as well as the corresponding nucleic acid amplification conditions, so that the probe can bind to the amplified target sequence, and variations of the target sequence can be detected by melting curve analysis. The present invention also encompasses a kit assembled according to the method described.
US08691500B2	Device and method for detecting biomolecule Disclosed are a method for detecting a biomolecule including: immobilizing a nucleic acid aptamer capable of specifically binding to a biomolecule to be detected on the surface of a bead on which fluorophores are arranged; hybridizing the nucleic acid aptamer with a guard nucleic acid (g-nucleic acid) labeled with a quencher to quench fluorescence; and reacting a sample including the biomolecule to be detected with the nucleic acid aptamer and detecting a fluorescence signal emitted as the biomolecule binds with the nucleic acid aptamer and the g-nucleic acid labeled with the quencher is separated, and a device for detecting a biomolecule for conducting the detection method. The present disclosure allows for effective, convenient and fast detection of the biomolecule to be detected, enables quantitative analysis, and enables detection of even a trace amount of sample.
US08691499B2	Method of detecting molecules Method of detecting molecules, using a sensor having a membrane layer having parallel pores extending through the membrane layer and incorporating therein probe molecules that bind with corresponding target molecules when present in the pores, electrodes, and an ionic solution in contact with the electrodes and the pores, wherein the electrodes are energized to induce an electrical current in the solution through the pores, wherein the electrical current induces an electrical parameter in the electrodes that is indicative of a through-pore electrical impedance of the pores, wherein the through-pore electrical impedance is increased when there is probe-to-target molecule binding in the pores relative to when there is an absence of such binding.
US08691497B2	Developing treatment method A developing treatment method includes: a treatment solution supplying step of supplying a treatment solution made by diluting a hydrophobizing agent hydrophobizing a resist pattern with hydrofluoroether onto a substrate on which a rinse solution has been supplied after development of the resist pattern; a hydrophobic treatment stabilizing step of stabilizing a hydrophobic treatment of the resist pattern with the supply of the treatment solution stopped and rotation of the substrate almost stopped; and a treatment solution removing step of removing the treatment solution from a top of the substrate on which the treatment solution has been supplied. The hydrophobizing agent is trimethylsilyldimethyl-amine.
US08691496B2	Method for forming resist under layer film, pattern forming method and composition for resist under layer film A method for forming a resist under layer film includes providing a composition for forming a resist under layer film on a substrate which is to be processed. The composition includes a solvent and a calixarene compound or a derivative of the calixarene compound. The composition is set under an oxidizing atmosphere with an oxygen content of 1% or more by volume to form a resist under layer film.
US08691493B2	Method for the production of a multilayer element, and multilayer element The invention relates to a method for producing a multilayer element (100), and also to a multilayer element (100) produced by said method. On and/or in a carrier ply (1) a decorative ply (3) is formed. The decorative ply (3) has a first region (8) and a second region (9). Viewed perpendicular to the plane of the carrier ply (1), the decorative ply (3) has in the first region (8) a first transmittance and in the second region (9) a second transmittance greater in comparison to the first transmittance. A layer (5) to be structured and a photoactivatable resist layer are disposed on the first side (11) of the carrier ply (1). On exposure of the resist layer through the decorative ply (3), the decorative ply (3) serves as an exposure mask. The at least one layer (5) to be structured and the resist layer are structured in register to one another by means of structuring operations synchronized with one another.
US08691491B2	Fluorine-containing compounds and their polymers useful for anti-reflection film materials and resist compositions A fluorine-containing compound represented by the formula 1, where R1 is a methyl group or trifluoromethyl group, each of R2 and R3 is independently a hydrogen atom or a group containing (a) a hydrocarbon group having a straight-chain, branched or ring form and having a carbon atom number of 1-25 or (b) an aromatic hydrocarbon group, the group optionally containing at least one of a fluorine atom, an oxygen atom and a carbonyl bond, l is an integer of from 0 to 2, each of m and n is independently an integer of 1-5 to satisfy an expression of m+n≦6, and when at least one of R1, R2 and R3 is in a plural number, the at least one of R1, R2 and R3 may be identical with or different from each other.
US08691490B2	Sulfonium salt, polymer, method for producing the polymer, resist composition and patterning process There is disclosed a sulfonium salt represented by the following general formula (1). In the formula, X and Y each represents a group having a polymerizable functional group; Z represents a divalent hydrocarbon group having 1 to 33 carbon atoms optionally containing a hetero atom; R1 represents a divalent hydrocarbon group having 1 to 36 carbon atoms optionally containing a hetero atom; and R2 and R3 each represents a monovalent hydrocarbon group having 1 to 30 carbon atoms optionally containing a hetero atom or R2 and R3 may be bonded with each other to form a ring together with a sulfur atom in the formula. There can be provided a sulfonium salt usable as a resist composition providing high resolution and excellent in LER in photolithography using a high energy beam such as an ArF excimer laser, an EUV light and an electron beam as a light source, a polymer obtained from the sulfonium salt, a resist composition containing the polymer and a patterning process using the resist composition.
US08691486B2	Electrostatic image developing toner, developer, image forming apparatus, image forming method, and process cartridge An electrostatic image developing toner including a toner particle (C), wherein the toner particle (C) has a structure in which a resin particle (A) containing at least a first resin (a) or a coated film (P) containing the first resin (a) is attached to a surface of a resin-containing particle (B) containing a second resin (b), and wherein the resin (b) includes a polyhydroxycarboxylic acid skeleton, and the resin (a) is a polyester resin containing a polybasic acid and a polyhydric alcohol.
US08691483B2	Toner for developing electrostatic charge image To provide a toner for developing an electrostatic charge image, which is free from fogging even by means of a high speed and long operating life machine and which brings about no OPC filming or soiling of components.A toner for developing an electrostatic charge image, which contains at least a binder resin and a colorant, wherein the toner has silica particles satisfying at least the following (1) to (3) and particles having an electrostatic property antipolar to the silica particles: (1) the average primary particle diameter is at least 60 nm and at most 300 nm, (2) the moisture content is at most 1.0 mass %, and (3) the absolute specific gravity is at least 2.0 and at most 2.4.
US08691482B2	Powder Coated Carrier The instant disclosure describes methods for preparing latex resins for coated carriers using surfactant partitioning, which resins exhibit both lower ζ potential and greater latex stability, while not adversely affecting particle size, toner charge or other metrics.
US08691481B2	Local exposure method and local exposure apparatus A local exposure method includes steps of: dividing a large block into a plurality of small blocks; setting irradiation illuminances different in a stepwise fashion; controlling light emission of light emitting elements based on the irradiation illuminances respectively set for the small blocks for a photosensitive film on a substrate moving with respect to light emitting elements; developing the photosensitive film having been subjected to exposure processing by irradiation by the light emitting elements; measuring a residual film thickness of the photosensitive film for each of the small blocks to obtain correlation data between the illuminance set for the small block and the residual film thickness; and obtaining a required illuminance of irradiation to each of the large blocks from a target residual film thickness of the photosensitive film set for each of the large blocks based on the correlation data.
US08691479B1	Optical mask for forming pattern An optical mask for forming a pattern is provided. The optical mask includes: a substrate including a light blocking pattern formed on portions of the substrate, wherein the light blocking pattern includes a halftone layer and a light blocking layer formed on the halftone layer, and the halftone layer and the light blocking layer overlap such that at least an edge portion of the halftone layer is exposed. A pitch of the light blocking pattern may about 6 μm, and a transmission ratio of the halftone layer may range from about 10% to about 50%.
US08691478B2	Attenuated phase shift mask for multi-patterning An attenuated phase shift mask (AttPSM) is fabricated with a set of fully transmitting regions, some parts adjacent phase-shifting regions with a first reduced transmission and first phase shift near 180 degrees, and remaining parts adjacent phase-shifting regions with a second transmission higher than the first transmission and second phase shift lower than the first phase shift.
US08691477B2	Reticle design for the reduction of lens heating phenomenon A reticle for lens heating mitigation includes a substrate, a target pattern and a redistributive pattern. The substrate includes a live pattern region and the target pattern is disposed within the live pattern region for constructing the target pattern onto a wafer. The redistributive pattern is also disposed within the live pattern region for redistributing energy onto a lens without being printed onto the wafer and without correcting said target pattern to be printed onto the wafer.
US08691473B2	Fuel cell module having non-planar component surface A fuel cell module may include a membrane electrode assembly two gas diffusion layers, two current collectors, two sealing members, and a fluid flow plate assembly. The membrane electrode assembly may include at least one membrane for fuel cell reactions, and the two gas diffusion layers may be respectively coupled with the two opposite sides of the membrane electrode assembly. The fluid flow plate assembly is coupled with the membrane electrode assembly at a first side of the two opposite sides of the membrane electrode assembly. At least one of the membrane electrode assembly, the two gas diffusion layers, the two current collectors, and the two sealing members has a non-planar surface prior to an assembly of the membrane electrode assembly, the two gas diffusion layers, the two current collectors, and the two sealing members, and the non-planar surface is at least partially flattened when the assembly occurs.
US08691470B2	Seal compositions, methods, and structures for planar solid oxide fuel cells A seal composition includes a first alkaline earth metal oxide, a second alkaline earth metal oxide which is different from the first alkaline earth metal oxide, aluminum oxide, and silica in an amount such that molar percent of silica in the composition is at least five molar percent greater than two times a combined molar percent of the first alkaline earth metal oxide and the second alkaline earth metal oxide. The composition is substantially free of boron oxide and phosphorus oxide. The seal composition forms a glass ceramic seal which includes silica containing glass cores located in a crystalline matrix comprising barium aluminosilicate, and calcium aluminosilicate crystals located in the glass cores.
US08691469B2	Proton conducting membranes for fuel cells having a proton gradient and methods for preparing said membranes A proton exchange membrane for a fuel cell, comprising a graft (co)polymer comprising a main chain and grafts comprising at least one proton acceptor group and at least one proton donor group.
US08691468B2	Fuel cell stack, and method for the production of a fuel cell stack The invention relates to a fuel cell stack comprising a base plate supporting fuel cells and a cap of an electrically insulating material, particularly of ceramics, for electrically insulating the fuel cells stacked on top of each other partially enveloping the fuel cells stacked on top of each other. According to the invention it is contemplated that a metal cap provided for guiding cathode gas envelops the cap including the fuel cells together with the base plate and that the metal cap is attached to the base plate in a sealed manner. The invention further relates to a method for producing a fuel cell stack.
US08691466B2	Membrane electrode assembly for fuel cell The present invention provides a method of preventing liquid fuel that has penetrated from an anode from reaching a cathode and of effectively utilizing a cathode catalyst, which provides a membrane electrode assembly for fuel cell having high output density. In a membrane electrode assembly for fuel cell including an anode formed of a catalyst and a solid polymer electrolyte, a cathode formed of a catalyst and a solid polymer electrolyte, and a solid polymer electrolyte membrane formed between the anode and the cathode, an intermediate layer is formed between the cathode and the electrolyte membrane.
US08691465B2	Fuel cell and method of operating fuel cell Provided is a fuel cell which has a buffer space provided on a downstream side of a fuel supply space, and in which an output of a most downstream fuel cell unit is less affected by impurity gas stored in the fuel supply space.
US08691464B2	Three dimensional single-chamber fuel cells The present invention relates to single chamber fuel cells and systems and methods associated with the same. Architectures and materials that allow for high performance, enhanced fuel utilization, mechanical robustness, and mechanical flexibility are described. In some embodiments, multiple fuel cell units are arranged in a single chamber and may be, in some cases, connected to each other (e.g., connected in series, connected in parallel, etc.). Each fuel cell unit can be defined as one or more anode(s), one or more cathode(s), and an electrolyte able to maintain electrical separation between the anode(s) and cathode(s). The multiple fuel cell units are arranged in stacks in some cases. In one set of embodiments, the stacks of fuel cell units can be shaped and/or arranged to enhance the mixing of fuel and oxidant, thus improving distribution of reactants in the reaction zone. For example, the stacks of fuel cells may be arranged as fins within the fuel cell chamber. In addition, the stacks of fuel cells may be porous in some instances. In addition, the stacks of fuel cell units may be arranged to enhance other fluid flow parameters (e.g., residence time, reactant distribution, etc.). In some cases, the enhanced fluid flow may lead to increased fuel utilization and system efficiency.
US08691458B2	Fuel cell system It is an object of the invention to improve the accuracy of estimating a moisture content and suppress an effect of remaining water at the startup of the fuel cell system.A fuel cell system includes: a fuel cell including a cell laminate; an estimating unit for estimating a residual water content distribution in the reactant gas flow channel and a moisture content distribution in the electrolyte membrane in a cell plane of each single cell while taking into consideration water transfer that occurs between the anode electrode and the cathode electrode via the electrolyte membrane; and an operation control unit for, based on an estimation result from the estimating unit, setting a scavenging time used in a scavenging process for the fuel cell after the fuel cell system is shut down.
US08691452B2	Apparatus for recirculation of a cathode gas in a fuel cell arrangement, method for shutting down such a fuel cell arrangement An apparatus for recirculation of a cathode gas in a fuel cell arrangement having a cathode gas supply for supplying the cathode gas to a cathode area, and a cathode gas outlet for carrying the partially consumed cathode gas out of the cathode area, includes a recirculation line for recirculation of the partially consumed cathode gas from a junction point in the cathode gas outlet into a supply point in the cathode gas supply. Blocking apparatus is provided to block the cathode gas supply in the flow direction upstream of the supply point and to block the cathode gas outlet in the flow direction downstream from the junction point, such that a closed circuit for the partially consumed cathode gas is formed when the blocking apparatus is closed.
US08691451B2	Method for controlling amount of air supplied to fuel cell The present invention provides a method for controlling the amount of air supplied to a fuel cell, which can prevent flooding and membrane dry-out in a fuel cell stack and, at the same time, ensure optimal performance of the fuel cell stack and a humidifier by supplying an optimal amount of air to the fuel cell stack at each operation condition.For this purpose, the present invention provides a method for controlling the amount of air supplied to a fuel cell, the method including measuring the temperature and pressure of humidifier outlet (stack inlet) air, the temperature and pressure of stack outlet air, and the relative humidity of the humidifier outlet (stack inlet) air, and determining the stoichiometric ratio of air or the amount of air supplied to the stack based on the measurement results so as to adjust the relative humidity of the stack outlet air reach a target value.
US08691450B1	Three-dimensional batteries and methods of manufacturing the same A three-dimensional battery having a plurality of non-laminar electrodes including a plurality of cathodes and a plurality of silicon anodes, and an electrolyte solution in fluid contact with the plurality of electrodes, wherein the electrolyte solution includes a selected one of lithium (bis)trifluoromethanesulfonimide (LiTFSI), LiClO4, LiCF3SO3, and LiBOB.
US08691448B2	Lithium secondary battery with anode containing aqueous binder Provided is a lithium secondary battery comprising an anode, a cathode and a non-aqueous electrolyte, wherein the anode includes an aqueous binder, and the non-aqueous electrolyte contains (a) a cyclic anhydride or a derivative thereof; and (b) any one anion receptor selected from the group consisting of a borane compound, a borate compound and mixtures thereof. According to the present invention, a stable SEI film is formed on the anode, and the life characteristics of the battery are improved by controlling the LiF content in the SEI film.
US08691445B2	Positive electrode including particles having bimodal size distribution for lithium secondary battery and lithium secondary battery having the same A positive electrode for a lithium secondary battery includes a positive activation material mixture that intercalates and de-intercalates lithium ions, wherein a first positive activation material having an average particle diameter D50 of from 12.5 μm to 22 μm and a second positive activation material having an average particle diameter D50 of from 1 μm to 5 μm are mixed with a weight ratio of from 95:5 to 60:40.
US08691443B2	Lithium-ion secondary battery and method of manufacturing same A lithium-ion secondary battery of this invention comprises a separator interposed between a positive electrode and a negative electrode. Moreover, a porous film of lithium titanate is formed on the surface of the negative electrode. In this lithium-ion secondary battery, when the separator is ruptured, short-circuiting of the positive electrode and negative electrode is suppressed by the lithium titanate porous film formed on the surface of the negative electrode. Further, in this configuration, a decline in the characteristics of storage of lithium ions in the negative electrode at low temperatures (low-temperature input characteristics) is suppressed.
US08691441B2	Graphene-enhanced cathode materials for lithium batteries A nano graphene-enhanced particulate for use as a lithium battery cathode active material, wherein the particulate is formed of a single or a plurality of graphene sheets and a plurality of fine cathode active material particles with a size smaller than 10 μm (preferably sub-micron or nano-scaled), and the graphene sheets and the particles are mutually bonded or agglomerated into an individual discrete particulate with at least a graphene sheet embracing the cathode active material particles, and wherein the particulate has an electrical conductivity no less than 10−4 S/cm and the graphene is in an amount of from 0.01% to 30% by weight based on the total weight of graphene and the cathode active material combined.
US08691430B2	Pouch-type lithium secondary battery having a variable tab The pouch-type lithium secondary battery includes an electrode assembly; a pouch for accommodating the electrode assembly; and a variable tab in electrical connection with one electrode tab of two electrode tabs of the electrode assembly and being parallel to the other electrode tab and being drawn outward from the pouch, wherein the position of the variable tab is adjustable with respect to the electrode tab in electrical connection therewith. Therefore, the present invention is capable of achieving easy positional adjustability of an electrode tab protruding outward from the pouch, during a battery assembly process. In addition, the present invention is capable of taking prompt measures in response to consumer demands by improving the design freedom of a battery pack particularly in a large-area battery.
US08691429B2	Polymer battery pack and method for manufacturing the same Disclosed are a polymer battery pack and a method for manufacturing the same. In the polymer battery pack, a bare cell and a protection circuit member are separated from each other by a holder frame such that the bare cell is coupled to the inner side of the holder frame and the protection circuit member is coupled to the outer side of the holder frame. The method for manufacturing the polymer battery pack includes: coupling a bare cell to the inner side of a holder frame; electrically connecting the bare cell to a protection circuit member; coupling the protection circuit module to the holder frame; coupling a cover to the holder frame; attaching an external label to the cover; attaching a water sensitive paper to the cover; and performing a function test for the battery.
US08691428B2	Battery pack comprising three case coverings A battery pack comprises a battery cell, a circuit module electrically connected to the battery cell, a first case covering one side of the battery cell, a second case covering an opposite side of the battery cell and one side of the circuit module, wherein the second case is coupled to the first case, and a third case covering an opposite side of the circuit module, wherein the third case is coupled to the first case and the second case.
US08691427B2	Method for manufacturing a battery shell applicable to an electronic device The disclosure discloses a method for manufacturing a battery shell applicable to an electronic device. The method includes providing a metal substrate, a metal implanting component including a connecting part disposed thereon; bonding the metal implanting component to the metal substrate; and forming a plastic component on the metal substrate by an insert molding process. The plastic component covers the metal implanting component. By bonding the plastic component to the bonding part of the metal implanting component, the bonding strength is enforced.
US08691413B2	Aqueous redox flow batteries featuring improved cell design characteristics This invention is directed to aqueous redox flow batteries comprising ionically charged redox active materials and separators, wherein the separator is less than about 100 microns and the flow battery is capable of operating with high energy densities and voltage efficiencies.
US08691406B2	Secondary battery and method for manufacturing the same A secondary battery secondary battery includes a bare cell having an electrode terminal, and a protective circuit module having a circuit board and a lead plate. The protective circuit module is electrically connected to the bare cell such that the electrode terminal and the circuit board are connected to each other through the lead plate. The lead plate includes a first plate mounted on the circuit board, and a second plate foldably connected to the first plate.
US08691404B2	High energy-density radioisotope micro power sources A method of constructing a solid-state energy-density micro radioisotope power source device. In such embodiments, the method comprises depositing the pre-voltaic semiconductor composition, comprising a semiconductor material and a radioisotope material, into a micro chamber formed within a power source device body. The method additionally includes heating the body to a temperature at which the pre-voltaic semiconductor composition will liquefy within the micro chamber to provide a liquid state composite mixture. Furthermore, the method includes cooling the body and liquid state composite mixture such that liquid state composite mixture solidifies to provide a solid-state composite voltaic semiconductor, thereby providing a solid-state high energy-density micro radioisotope power source device.
US08691403B2	Method for anodizing aluminum and anodized aluminum A method for anodizing aluminum, wherein an object (29) made of aluminum or an aluminum alloy is anodized in an electrolytic solution (25), and thereby an anodized aluminum film is formed on a surface of the object (29), is provided. The electrolytic solution (25) is comprised of at least one acid selected from organic acids having two or more carboxylic groups, moves at an average speed of 15 cm/sec or less along at least an outer surface of the object (29). The anodization is performed under conditions that a temperature of the outer surface of the object (29) is 80° C. or less, and current density is in a range from 10 to 170 A/dm2.
US08691399B2	Electron-transporting materials and processes for making the same Compounds of formula I may be used in optoelectronic devices wherein R1 and R2 are, independently at each occurrence, H, a C1-C20 aliphatic radical, a C3-C20 aromatic radical, or a C3-C20 cycloaliphatic radical; a is an integer ranging from 0-2; b is 1 or 2; c is an integer ranging from 0-4; and Ar1 and Ar2 are independently heteroaryl.
US08691397B2	Biocidal metallic layers comprising cobalt Free standing articles or articles at least partially coated with substantially porosity free, fine-grained and/or amorphous Co-bearing metallic materials optionally containing solid particulates dispersed therein, are disclosed. The electrodeposited metallic layers and/or patches comprising Co provide, enhance or restore strength, wear and/or lubricity of substrates without reducing the fatigue performance. The fine-grained and/or amorphous metallic coatings comprising Co are particularly suited for articles exposed to thermal cycling, fatigue and other stresses and/or in applications requiring anti-microbial properties.
US08691394B2	Heat shrinkable multilayer film and heat shrinkable label It is an object of the present invention to provide a heat-shrinkable multilayer film which, in the case of using the heat-shrinkable multilayer film as a heat-shrinkable label for a container, does not produce delamination in covering a container, is superior in heat resistance, oil resistance, tearing properties along the perforation and appearance and can prevent the reduction in strength between the layers after a printing step, and a heat-shrinkable label comprising the heat-shrinkable multilayer film as a base film. The present invention is a heat-shrinkable multilayer film which comprises: an outer surface layer comprising a polyester type resin; and an intermediate layer comprising a polystyrene type resin, said outer surface layer and said intermediate layer being laminated by interposing an adhesive layer comprising a polyester type elastomer or a modified polyester type elastomer.
US08691388B2	Fluoropolymer containing laminates The multilayer film serves as a laminate. The film is a multilayered structure that, in its base form, encompasses an intermediate layer with first and second outer layer affixed to opposing sides of the intermediate layer. The first outer layer is a semi-crystalline fluoropolymer. The intermediate layer includes a polyester and the second outer layer is an olefinic polymer. The layers are bonded together in the noted order to provide the multilayer film.
US08691384B2	Metallic nanoparticles having enhanced dispersibility in aqueous media comprising a polymer having alkyl acrylamide side chains Water-dispersible nanoparticles are prepared by applying a coating of a multiply amphipathic dispersant to the surface of a hydrophobic nanoparticle comprised of a semiconductive or metallic material. The multiply amphipathic dispersant has two or more hydrophobic regions and two or more hydrophilic regions, and is typically polymeric. Preferred polymeric dispersants are comprised of (1) a hydrophobic backbone with hydrophilic branches, (2) a hydrophilic backbone with hydrophobic branches, or (3) a backbone that may be either hydrophobic or hydrophilic, and substituted with both hydrophilic and hydrophobic branches. Monodisperse populations of water-dispersible nanoparticles are also provided, as are conjugates of the water-dispersible nanoparticles with affinity molecules such as peptides, oligonucleotides, and the like.
US08691382B2	Fastener with adhesive base and twist-tie A fastener and a method of making and using the fastener is provided in which the fastener includes a base having a top portion and a bottom portion. The bottom portion includes an adhesive layer portion. An elongated pliable core member is coupled to the base, with the core member having first and second ends, with at least the first end extending beyond an edge of the base. In another embodiment the base is configured to define a plurality of notches, with each notch configured to define an apex proximate the center of the base and extending with the edges toward an edge of the base and with two notches on each side of elongated pliable core member. The plurality of notches defines two sections of the base, with one section configured independently of the other section and with one section on each side of the elongated pliable core member.
US08691378B2	Cutting tool The invention relates to a cutting tool having a substrate base body and a single or multi-layered coating attached thereupon, wherein at least one layer of the coating is a metal oxide layer produced in the PVD process or in the CVD process and the metal oxide layer has a grain structure wherein there is structural disorder within a plurality of the existing grains that are characterized in that in electron diffraction images of the grains, point-shaped reflections occur up to a maximum lattice spacing dGRENZ and for lattice spacing greater than dGRENZ no point-shaped reflections occur, but rather a diffuse intensity distribution typical for amorphous structures.
US08691377B2	Semiconductor device A semiconductor device of the present invention includes a supporting board, an electrode surface processing layer formed on the supporting board, a semiconductor element, and a solder material containing a first metal composed mainly of bismuth and a second metal having a higher melting point than the first metal and joining the electrode surface processing layer and the semiconductor element, the first metal containing particles of the second metal inside the first metal. The composition ratio of the second metal is higher than the first metal in a region of the solder material corresponding to the center portion of the semiconductor element, and the composition ratio of the second metal is at least 83.8 atomic percent in the region corresponding to the center portion.
US08691376B2	Self-decontaminating inorganic coatings containing semiconductor metal oxide nanoparticles UV resistant inorganic coatings which exhibit photochemical activity that destroys toxic biological and chemical agents are disclosed. The inorganic coatings include semiconductor metal oxide nanoparticles that are photo-chemically active dispersed in an inorganic binder. In one embodiment, anatase titanium dioxide nanoparticles are dispersed in a silicon dioxide or silicate binder. Applications may include spacecraft, aircraft, ships, military vehicles, high value equipment and buildings such as subway stations, hospitals, railroad stations and stadiums.
US08691373B2	Laminate or thermoplastic polymer composition having low air permeability and pneumatic tire using same as inner liner A laminate (C) of a thermoplastic polymer composition comprising: a thermoplastic resin composition (A) having an permeation coefficient of 10×10−12 cc·cm/cm2·sec·cmHg or less, laminated with a thermoplastic polymer composition (B) having a melt viscosity of 500-2000 Pa·s and a Young's modulus at a room temperature of 1-400 MPa, wherein the thickness of a layer of the thermoplastic resin composition (A) is 0.05-10 μm and the air permeation coefficient of the laminate (C) of 20×10−12 cc·cm/cm2·sec·cmHg or less, and a pneumatic tire using the above laminate (C) as an inner liner.
US08691364B2	Laminate, and polishing material and grinding material using the same, and method for producing the laminate The invention provides a laminate capable of polishing and grinding the surface of a material having a high hardness such as diamond, sapphire or hard carbon film, rapidly and in a simplified manner with high planarity and high accuracy, utilizing the high adhesiveness to substrates, the hardness and the surface planarity that a carbon film has, but using neither diamond abrasive grains nor alkali slurry. The laminate comprises a substrate and a carbon layer provided on the substrate, wherein the carbon layer comprises a diamond fine grain provided on the substrate and crushed by impact given thereto, a formation/growth inhibiting material that inhibits the formation of an impurity inhibiting the growth of a carbon grain and/or inhibits the growth of a carbon grain, and a carbon grain, and an amount (amount per unit volume) of the formation/growth inhibiting material decreases from a lower layer toward an upper layer on the substrate side. Preferably, the formation/growth inhibiting material is an SiO2 material or an Al2O3 material, and optionally an adhesiveness-reinforcing layer comprising titanium or a titanium alloy or the like may be provided between the substrate and the carbon layer.
US08691359B1	Vehicle CD player plug-cover A vehicle CD player plug-cover that includes a parallelepiped cover having a parallelepiped insert projecting perpendicularly from a rear surface, which insert releasably inserts into an automobile CD player to conceal the CD player from view.
US08691355B2	Film dressing Disclosed is a film dressing comprising a film dressing body. The film dressing body (1) comprises a film (2) and a pressure-sensitive adhesive layer (3) provided on one side of the film (2). The film dressing further comprises a release liner (4) covering the pressure-sensitive adhesive layer (3) on its adhesive face, and a carrier (5) covering the backside of the film (2). A carrier division part (5d) is provided to divide the carrier (5) into a carrier first part (51) and a carrier second part (52). A flap layer (7) is stacked so as to cover the carrier division part (5d). A flap layer division part (7d) is provided in the flap layer (7) to divide the flap layer (7) into a flap layer first part (71) and a flap layer second part (72) which are partially joined respectively on the carrier first pat (51) and the carrier second part (52). Preferably, division parts (4d1, 4d2) are provided in the release liner (4).
US08691351B2	Antireflection film, polarizing plate and image display device An antireflection film includes, in a following order, a transparent substrate film; a medium refractive index layer; a high refractive index layer; and a low refractive index layer, wherein the medium refractive index layer is (A) a medium refractive index layer having a refractive index of 1.60 to 1.64 at a wavelength of 550 nm and a thickness of 55.0 to 65.0 nm, the high refractive index layer is (B) a high refractive index layer having a refractive index of 1.70 to 1.74 at a wavelength of 550 nm and a thickness of 105.0 to 115.0 nm, and the low refractive index layer is (C) a low refractive index layer having a refractive index of 1.32 to 1.37 at a wavelength of 550 nm and a thickness of 85.0 to 95.0 nm.
US08691349B2	Liquid crystal display panel and fabricating method thereof A liquid crystal display panel including a first substrate, a second substrate, a liquid crystal layer, and a polymer stabilized alignment layer is provided. The second substrate is disposed opposite to the first substrate. The liquid crystal layer is disposed between the first substrate and the second substrate. The polymer stabilized alignment layer is disposed between the first substrate and the liquid crystal layer, and an average surface roughness of the polymer stabilized alignment layer is greater than or equal to 10 nm.
US08691346B2	Methods and compositions for coating aluminum substrates The present invention relates to methods and compositions for coating aluminum substrates. In an embodiment, the invention includes a method of applying a coating on an aluminum substrate including contacting the aluminum substrate with a first solution. The first solution can include a zinc metal salt, a sugar acid or alkali metal salt thereof, and an alkali metal hydroxide. The method can also include contacting the aluminum substrate with a second solution. The second solution can include a molybdate salt, an alkanolamine, and a fluorine acid. Other embodiments are also included herein.
US08691345B2	Apparatus and method for printing in both image and aroma domains intelligently A method comprising an algorithm for automatically detecting an object in a digital image in order to determine if a scent can be associated with the detected object and applying the scent to the print medium, and a printer equipped to apply the scent.
US08691340B2	Preservation of wood, compositions and methods thereof The disclosure relates to compositions for wood preservation and methods of applying compositions for wood preservation. The compositions comprise nonionic surfactant mixtures and prepolymer. Compositions of nonionic surfactant mixtures and prepolymers can be used advantageously in methods to preserve wood by impregnation of the wood with preservatives at ambient atmospheric pressures.
US08691338B2	Polymerized film forming method and polymerized film forming apparatus A first substrate has a source material forming surface on which source materials for forming a polymerized film is formed in a predetermined pattern, and a second substrate has a film forming surface on which the polymerized film will be formed. Here, the first substrate and the second substrate are installed in a processing chamber such that the source material forming surface and the film forming surface face each other. Then, the first substrate is heated to a first temperature at which the source materials on the source material forming surface are evaporated and the second substrate is heated to a second temperature at which the source materials cause polymerization reaction on the film forming surface. Therefore, the polymerized film is formed on the film forming surface by reacting the source materials and evaporated from the first substrate on the film forming surface of the second substrate.
US08691337B2	Techniques for applying mar reducing overcoats to articles having layer stacks disposed thereon Certain example embodiments of this invention relate to techniques for applying an overcoat (e.g., which may include an organic material) to a coated article having a layer stack already disposed thereon in order to reduce the potential for surface marring. An evacuative process may be used to deposit the mar reducing overcoat. The coated article including the mar-reducing overcoat has a contact angle greater than, and a surface friction less than, a contact angle and a surface friction of the single- or multi-layer stack supported by the substrate alone. Any marring due to cat-scratching or the like preferably would not be visible at 4× magnification following application of the mar reducing overcoat.
US08691335B2	Coating a substance with graphene Technologies are generally described for a system and process effective to coat a substance with graphene. A system may include a first container including graphene oxide and water and a second container including a reducing agent and the substance. A third container may be operative relationship with the first container and the second container. A processor may be in communication with the first, second and third containers. The processor may be configured to control the third container to receive the graphene oxide and water from the first container and to control the third container to receive the reducing agent and the substance from the second container. The processor may be configured to control the third container to mix the graphene oxide, water, reducing agent, and substance under sufficient reaction conditions to produce sufficient graphene to coat the substance with graphene to produce a graphene coated substance.
US08691333B2	Methods for manufacturing engine components with structural bridge devices A method is provided for manufacturing an engine component. The method includes providing a structural bridge device on a base block; forming a component portion on the structural bridge device with an additive manufacturing technique; removing the component portion from the base block and the structural bridge device; and finishing the component portion to form the engine component.
US08691330B2	Optical film having antistatic layer, antireflection film, polarizing plate and image display device An optical film having a transparent support having thereon at least a hardcoat layer and an antistatic layer in this order, wherein the hardcoat layer and the antistatic layer are formed by simultaneously coating compositions for forming respective layers, the antistatic layer comprises at least (A) an electrically conductive organic compound and (B) a polyfunctional monomer having three or more polymerizable groups, a content of an inorganic oxide fine particle in the antistatic layer is less than 10 weight % based on an entire solid content of the antistatic layer, and a common logarithmic value (LogSR) of surface resistivity SR (Ω/sq) on the antistatic layer side with respect to the transparent support is 13 or less.
US08691324B2	Dry coating processes for substrates Disclosed herein are solvent free, dry coating processes for applying a layered material such as graphene, nanoplate graphite, etc., to a substrate. The applied layered material is devoid of any dispersant and substantially uniform in thickness. Generally, a layered material precursor composition is mixed with a milling medium so that the milling medium is coated with the layered material. The substrate is then contacted with the coated milling medium. The layered material on the milling medium transfers to the substrate to form a coating on the substrate. Such processes may be especially useful for applying conductive films onto a polymeric substrate without the need for additives such as a surfactant or a polymeric binder.
US08691323B2	Method and apparatus for monitoring and controlling the application of performance enhancing materials to creping cylinders A method for monitoring and controlling the thickness of coating on a creping cylinder is disclosed. The methodologies involve a coordinated scheme of apparatuses that function to monitor various aspects of a creping cylinder coating so that the thickness of the coating can be determined.
US08691319B2	Large glassy beads The present invention relates to a particulate composition in the form of a large spherical glassy bead having a cross-sectional diameter greater than 5 mm. The bead comprises an encapsulating carrier composition essentially made of fibrous materials, which are both sugarless and non-cariogenic and an encapsulant, such as a flavor material.
US08691318B2	Production of soluble protein solutions from soy (“S701”) A soy protein product, which may be an isolate, produces transparent heat-stable solutions at low pH values and is useful for the fortification of soft drinks and sports drinks without precipitation of protein. The soy protein product is obtained by extracting a soy protein source material with an aqueous calcium salt solution to form an aqueous soy protein solution, separating the aqueous soy protein solution from residual soy protein source, adjusting the pH of the aqueous soy protein solution to a pH of about 1.5 to about 4.4 to produce an acidified clear soy protein solution, which may be dried, following optional concentration and diafiltration, to provide the soy protein product.
US08691316B2	Bake-stable creamy food filling base Lipid-based, creamy food fillings are disclosed that are bake-stable up to a temperature of at least about 125° C. The creamy food fillings are particularly suitable for use in products that require the filling to be added prior to baking. In one aspect, the fillings are a solid-in-liquid dispersion having a dispersed solid phase including a hydrophilic powder and a high-melting lipid, as well as a continuous lipid phase including a low-melting lipid in which the hydrophilic powder and high-melting lipid are dispersed. Preferably, the fillings have a low water activity of about 0.5 or lower and are formed in the absence of additional humectants, thickening agents, or gelling agents.
US08691313B2	Non-protein foaming compostitions and methods of making the same A soluble foaming composition is provided which contains carbohydrate particles having a plurality of voids containing entrapped pressurized gas and less than two percent protein. The composition may include a surfactant and may be contained in a food product such as a beverage mix or an instant food. In addition, a method is provided for manufacturing the foaming composition in which the particles are heated and an external pressure exceeding atmospheric pressure is applied to the soluble foaming particles. The soluble foaming particles are cooled and the external gas pressure is released resulting in pressurized gas remaining in internal voids of the particles of the foaming composition.
US08691310B2	Method of extending the production time of a pasteuriser The invention relates to a method of extending the production time of a pasteuriser. The pasteuriser is of the type which includes a plate heat exchanger with a number of sections, of which at least one section consists of regenerative section. The method comprises raising the temperature in the downstream part of the regenerative section to a temperature above 50° C., during a certain predetermined period of time and at regular intervals. During normal production, a part quantity of the product which passes downstream of the regenerative section is shunted past the regenerative section. At the regular intervals and during the predetermined period of time, a part quantity of the product which passes upstream of the regenerative section is shunted past the regenerative section. At the same time, all product passes the downstream part of the regenerative section during the predetermined period of time.
US08691301B2	Surfactant gas pressurized liquid composition and method and package for delivering A self gassing composition comprising at least one surfactant and a fermentation base including a gas producing organism and at least one sugar is disclosed. Use of a nonionic surfactant in the self gassing composition allows the fermentation base to continue reacting and producing gas. Additionally, a personal care cleansing product and method for storing and delivering an aqueous composition having at least one surfactant and pressurized gas dissolved therein is disclosed. In one aspect, the composition is stored in an internal reservoir in a container such that when a sealing device is removed from a valveless opening, the composition foams and plumes out the opening of the container as the gas dissolved in the composition is released. In addition to the self gassing composition, a pressurized gas may be injected into a surfactant composition to produce the gas pressurized cleaning composition.
US08691295B2	Dietary supplement for vascular health The present invention relates to an herbal dietary supplement to promote vascular health. The dietary supplement comprises L-Arginine, L-Citrulline, Ginkgo Biloba, Horse chestnut, Red Yeast Rice and Cayanne Pepper.
US08691292B2	Disinfectant formulation An aqueous disinfectant formulation comprising at least one phenolic compound of natural origin; a surfactant sufficient to form a solution or dispersion of the essential oil in an aqueous carrier; a solvent, and sufficient water to make 100 weight percent is described herein.
US08691289B2	Methods of treating outer eye disorders using high ORP acid water and compositions thereof The present invention relates to a method of treating an outer eye disorder selected from a cataract, neovascularization, keratitis, epithelium deficiency, or chronic opacity, by administering to the eye a composition comprising acidic electrolytic water. The present invention also relates to a stable acidic electrolyzed oxidizing water characterized by low conductivity, the presence of dissolved chlorine gas (Cl2), hypochlorous acid (HOCl) and chloride ions (Cl−), and by the presence of negligible quantities of hypochlorite ion (OCl−).
US08691287B2	Ophthalmic system with synergistic properties Disclosed herein are ophthalmic cleaning systems and methods for their use, which comprise an ophthalmic solution and lens case, wherein the solution includes dual disinfectants and the lens case includes silver. When the lens case is combined with the solution according to the system of the present invention, it surprisingly exhibits synergistic activity which results in a faster antimicrobial activity.
US08691286B2	Sputum dissolving suctioning solution for endotracheal and tracheostomy tubes A composition for dissolving or reducing the viscosity of sputum on a surface of a device includes an effective amount of glycerol and an effective amount of dextran sulfate in a saline solution. The effective amount of glycerol is between about 30-50% and the effective amount of dextran sulfate is between about 10-30%. The composition may further include an antimicrobial agent.
US08691279B2	Polysaccharide and protein-polysaccharide cross-linked hydrogels for soft tissue augmentation Disclosed herein are cohesive soft tissue fillers, for example, dermal and subdermal fillers, based on hyaluronic acids and optionally including proteins. In one aspect, hyaluronic acid-based compositions described herein include zero-length cross-linked moieties and optionally at least one active agent. The present hyaluronic acid-based compositions have enhanced flow characteristics, hardness, and persistence compared to known hyaluronic acid-based compositions. Methods and processes of preparing such hyaluronic acid-based compositions are also provided.
US08691277B2	Long acting sustained-release formulation containing dopamine receptor agonist and the preparation method thereof The present invention relates to a long-acting sustained-release dosage form for treatment of Parkinson Disease, comprising a dopamine receptor agonist and a pharmaceutically acceptable biodegradable polymer accessories, wherein the content of the dopamine receptor agonist in the sustained-release dosage form is 5-50% by weight, and the content of the pharmaceutically acceptable polymer accessories is 50-95% by weight.
US08691273B2	Method for producing hydroxyapatite particles This invention relates generally to a preparation of bone repair compositions, and more special refers to a novel technology in preparing a matrix building polymer i.e. collagen with inclusions of hydroxyapatite particles as biomaterial for medical applications. In this composition that consists of hydroxyapatite particles embedded in a matrix at least 50% nm. Said composition is suitable as bone implant material, dental cement and for applications in wound healing.
US08691270B2	Misuse preventative, controlled release formulation Disclosed is a misuse preventative, controlled release formulation comprising a core comprising a superabsorbent material (for example, polycarbophil), a controlled release coat surrounding the core, and a plurality of controlled release microparticles having a pharmaceutically active agent (for example, an opioid analgesic) disposed within the core, the coat, or both the core and the coat. When crushed, either intentionally or accidentally, and exposed to an aqueous medium, the superabsorbent material present in the core swells to encapsulate the microparticles, which remain substantially intact thereby retarding the release of the pharmaceutically active agent from the formulation. Also disclosed is a method of using the misuse preventative, controlled release formulation to deliver a pharmaceutically active agent to a mammal, for example, a human, in need thereof.
US08691268B2	Transdermal delivery using encapsulated agent released by ultrasound and/or heat A method for delivery of substance through at least one dermal layer, by providing a substance in microcapsules at a predetermined size, within a medium (150) for holding the microcapsules; placing the medium for holding the microcapsules on a surface of a patch (100) adjacent the skin (320) of a human or animal; and applying energy (200) to the patch, the energy having a characteristic of disturbing the integrity of the microcapsules, thereby resulting in release of the substance from the microcapsules. The energy may be selectively applied to release the substance at desired times. The substance may be a drug or other active agent.
US08691263B2	Extracellular matrix comprising platelet concentrate and cryoprecipitate polymerized in situ The present invention describes an extracellular matrix comprising human platelet derived growth factors, that permits the maximizing of therapeutic efficacy, combining the benefits of both components, to result in a more efficient and rapid integration of the matrix up to the structurally organized reconstruction of the neoformed tissue “in vivo”.
US08691261B2	Drug, drug guidance system, magnetic detection system, and drug design method It is intended to provide a drug delivery system which makes it possible to solve the existing technical problems and is easily usable in practice. A drug, which comprises an organic compound or an inorganic compound and has been magnetized by modifying a side chain and/or crosslinking side chains, is induced by a magnetic force into target tissues or an affected part.
US08691258B2	Anti-infective medical device Implantable medical devices (IMDS) having anti-infective properties are described. Anti-infective agents are disposed in, on, or about at least a portion of a surface of the medical device. The anti-infective agents are disposed in or on a vehicle, which may be in the form of a coating layer or covering. The vehicle may be biodegradable so that, over time, the anti-infective agent is removed from a tissue location into which the device is implanted, reducing the likelihood that microorganisms resistant to the anti-infective agent will develop. IMDs having an anti-infective agent and an anti-activity agent disposed therein, thereabout, or thereon are also described. The anti-activity agent interferes with the activity of the anti-infective agent, may be released from a surface at the IMD at a time when activity of the anti-infective agent is no longer desired, and may reduce the likelihood that microorganisms resistant to the anti-infective agent will develop.
US08691254B2	Hydrophilic coating An antimicrobial coating slurry includes about 15.5 wt % of a wetting agent, about 6.0 wt % of an insolubilizer, about 1.1 wt % of a biocide agent, and about 7.8 wt % of an inorganic material that includes lithium oxide and the balance water. The slurry is applied to a heat exchanger surface, cured, and washed to form a hydrophilic coating that includes lithium silicate. The hydrophilic coating provides improved moisture wicking and a reduced dissolution rate of biocide, which is held within a lithium silicate matrix.
US08691252B2	Storage-stable, anti-microbial compositions including ceragenin compounds and methods of use Storage-stable, anti-microbial compositions and products include a carrier and a ceragenin compound suspended in the carrier. Ceragenin compounds suspended in the carrier include a sterol backbone and a number of cationic groups attached to the sterol backbone via hydrolysable linkages. The carrier has a pH of 5.5 or less, which acts to stabilize the hydrolysable linkages and increase the shelf-life of the anti-microbial compositions and anti-microbial products. Nevertheless, the ceragenin compounds described herein are designed to break down relatively quickly (e.g., within about 5 days) if the pH environment of the ceragenin compounds is raised to about pH 6.5 or greater.
US08691251B2	Core-shell particles with a high content of glycerol, their production and use The invention relates to core-shell particles, the shell of which includes aggregated, hydrophobicized silicon dioxide particles, and the core of which includes a liquid phase, and in which the ratio of aggregated, hydrobicized silicon dioxide particles to the liquid phase, based on the total weight of the particles, is 2:98 to 40:60, where 60-100% by weight of glycerol is present in the liquid phase. The invention further encompasses the production of these core-shell particles and also their use for cosmetic purposes.
US08691250B2	Use of charged surfactants for reducing textile staining by antiperspirants The invention comprises the use of one or more charged surfactants in preparations having an antiperspirant effect for reducing staining in or on clothing and improving improvement the ability of stains to be washed out of the clothing.
US08691248B2	Stable three-phased emulsions Disclosed is a three-phase emulsion comprising an aqueous-gel outer phase; and a water-in-oil inner phase, wherein the emulsion is stable. The aqueous-gel outer phase can include 10% to 50% by weight of the total weight of the emulsion. This phase can also include 70% to 95% by weight of water based on the total weight of the aqueous-gel outer phase, a gelling agent, and an emulsifier having a hydrophilic-lipophilic balance (HLB) value of 10 to 19. The water-in-oil inner phase can include 50% to 95% by weight based on the total weight of the three-phase emulsion. This phase can also include 50% to 80% by weight of water based on the total weight of the water-in-oil inner phase, 20% to 50% by weight of oil based on the total weight of the water-in-oil inner phase, and an emulsifier.
US08691243B2	Protein-based Streptococcus pneumoniae vaccine Vaccine compositions and methods for protecting a mammalian subject against infection with S. pneumoniae are disclosed. The vaccines and methods comprise an effective amount of one or more Streptococcus pneumoniae cell wall and/or cell membrane proteins and/or immunogenically-active fragments, derivatives or modifications thereof, wherein the proteins are selected from a defined group of proteins associated with age-dependent immunological responses.
US08691239B2	Influenza hemagglutinin and neuraminidase variants Polypeptides, polynucleotides, methods, compositions, and vaccines comprising influenza hemagglutinin and neuraminidase variants are provided.
US08691238B2	High growth reassortant influenza A virus The present invention provides a high growth reassortant influenza A virus having at least two gene segments of seasonal or pandemic strain origin, a PB1 gene segment of A/Texas/1/77 strain origin and a PA gene segment of A/Puerto Rico/8/34 (H1N1) origin coding for a PA protein comprising at least one amino acid modification at any one of positions 10, 275, 682, according to SEQ ID No. 1. Further provided are vaccine formulations comprising the reassortant influenza A virus of the invention.
US08691234B2	Vaccine formulation potentiated by the combination of DNA and an antigen Formulation of vaccine antigens, containing as main components: a—) one or several DNA expressing one or several proteins in the immunized individuals and b—) a viral antigen, in appropriate proportions. Development of new formulations, minimizing the number of components that enhance and diversify the spectrum of immune response against different pathogenic entities and generating combined vaccines against pathogens.These formulations can be applied in the pharmaceutical industry for preventive and-or therapeutic use in human.
US08691231B2	Methods of treatment of tumors expressing predominantly high affinity EGFR ligands or tumors expressing predominantly low affinity EGFR ligands with monoclonal and oligoclonal anti-EGFR antibodies Disclosed are pharmaceutical preparations for, and methods for determining, appropriate and effective treatment with therapeutic agents comprising a single species of anti-EGFR monoclonal antibody or therapeutic agents comprising a plurality of species of such antibodies, as well as kits useful for making such determinations.
US08691229B2	Method of PLSCR inhibition for cancer therapy The present invention relates to a method of using inhibitors of phospholipid scramblases (PLSCRs) for the prophylactic or therapeutic treatment of cancers. The PLSCR-inhibitors of the invention comprise compounds PLSCR-specific monoclonal antibodies, antagonists or nucleic acids, which have ability to decrease the level and/or biological activity of PLSCRs in cancer cells.
US08691228B2	Stable and soluble antibodies inhibiting TNFα The present invention relates to particularly stable and soluble scFv antibodies and Fab fragments specific for TNFα, which comprise specific light chain and heavy chain sequences that are optimized for stability, solubility, in vitro and in vivo binding of TNFα, and low immunogenicity. Said antibodies are designed for the diagnosis and/or treatment of TNFα-related disorders. The nucleic acids, vectors and host cells for expression of the recombinant antibodies of the invention, methods for isolating them and the use of said antibodies in medicine are also disclosed.
US08691225B2	Antibodies against the ectodomain of ErbB3 and uses thereof The present invention provides a novel class of antibodies and antigen binding fragments thereof that bind the extracellular domain of ErbB3 receptor and inhibit various ErbB3 functions. For example, the antibodies and antigen binding fragments described herein are capable of binding to the receptor designated ErbB3 and inhibiting EGF-like ligand mediated phosphorylation of the receptor. Such antibodies and antigen binding fragments thereof have the useful characteristic of inhibiting the proliferation of cancer cells expressing ErbB3.
US08691223B2	Human binding molecules capable of neutralizing influenza virus H5N1 and uses thereof Described are binding molecules such as human monoclonal antibodies that bind to influenza virus H5N1 and have neutralizing activity against influenza virus H5N1. Also described are nucleic acid molecules encoding the antibodies, and compositions comprising the antibodies and methods of identifying or producing the antibodies. The antibodies can be used in the diagnosis, prophylaxis, and/or treatment of an influenza virus H5N1 infection. In certain embodiments, the antibodies provide cross-subtype protection in vivo, such that infections with H5, H2, H6, H9, and H1-based influenza subtypes can be prevented and/or treated.
US08691221B2	Analgesic treatment with prolonged effect Use of an anti-TrkA antibody capable of inhibiting the binding between NGF and TrkA, in particular capable of blocking the biological activity of TrkA, for the preparation of a medicament for treating and/or preventing chronic pain.
US08691220B2	Powdery malted rice extract composition Disclosed are an agent for promoting proliferation of lactic acid bacteria, a preservative, and others, all of which do not deteriorate the flavor of food products. Specifically disclosed is a powdery malted rice extract composition obtained by inoculating lactic acid bacteria in a liquid prepared from a water extract of malted rice so that its Brix degree is 0.01 to 10, culturing the bacteria in the liquid, followed by drying the resulting culture.
US08691218B2	Vermin extermination using lysozyme, salt or biological fragment thereof, or lysozyme-related peptide as an egg recognition pheromone The present invention provides a mimetic egg comprising lysozyme, a salt or biological fragment thereof or a lysozyme-related peptide and an active ingredient in its base material mimicking an egg of a vermin; and a vermin exterminating method using the mimetic egg.
US08691217B2	Placental stem cell populations The present invention provides placental stem cells and placental stem cell populations, and methods of culturing, proliferating and expanding the same. The invention also provides methods of differentiating the placental stem cells. The invention further provides methods of using the placental stem cells in assays and for transplanting.
US08691215B2	Anti-viral protection with viruses containing defective genome segments The invention relates to virology and the prevention and/or treatment of viral infection and disease in animals, including birds and humans. The invention relates to the field of antiviral treatments. The invention further relates to methods of stimulating innate immunity and natural interferon production in humans or animals and in component parts of humans or animals, including cells and tissues. The invention also relates to the field of defective interfering (DI) viruses, including cloned DI viruses.
US08691214B2	Use of Lactobacillus for treatment of virus infections The present invention relates to the use of at least one strain of probiotic bacteria selected from Lactobacillus for the manufacture of a pharmaceutical composition for the treatment and/or prevention of a virus infection.
US08691213B2	Protein free formula The invention relates to the use of composition comprising free amino acids as a sole source of protein, a fatty acid source comprising long chain polyunsaturated fatty acids, a carbohydrate source comprising digestible and indigestible carbohydrates, and milk protein free Bifidobacteria for treating a person suffering from (a) colic, congestion, runny nose, wheezing, vomiting, diarrhea, bloody stools, mucus in stools, rash, eczema, gastroesophageal reflux, eosinophilic esophagitis or asthma; (b) cow's milk allergy and/or food protein intolerance; and/or (c) infections, wherein the indigestible carbohydrate is selected from a milk protein free source and the total composition is essentially free of intact proteins.
US08691210B2	Methods and compositions for generating an immune response by inducing CD40 and pattern recognition receptors and adaptors thereof Provided are methods for activating an antigen-presenting cell and eliciting an immune response by inducing pattern recognition receptor activity, and CD40 activity. Also provided are methods for activating an antigen-presenting cell and eliciting an immune response by inducing CD40 activity without prostaglandin E2. Also provided are methods for activating an antigen-presenting cell and eliciting an immune response by inducing an inducible chimeric molecule comprising a region of a pattern recognition receptor or an adaptor thereof.
US08691207B2	Transplantation of cells expressing markers for photoreceptor cells and retinal ganglion cells induced from Müller stem cells A method for the production of retinal cells, useful in transplantation therapy, comprises: (i) obtaining one or more mammalian adult Müller cells; and (ii) culturing the cells in the presence of an extracellular matrix protein and a growth factor to thereby induce dedifferentiation of the Müller cells into a progenitor phenotype.
US08691201B2	Deodorant material An object of the present invention is to provide a deodorant material having an excellent capability of removing an odor, especially a distinctive body odor of the middle-aged and elderly. The deodorant material comprises a polyurethane resin capable of removing the odor of nonenal, preferably further capable of removing the odor of at least one selected from the group consisting of ammonia, acetic acid, and isovaleric acid.
US08691200B2	Pump-dispenser bottle device containing a polycondensate comprising at least one polyurethane and/or polyurea unit The invention concerns aerosol devices comprising a reservoir containing, in a cosmetically suitable medium, a multiple-block polymer (A) comprising at least a polyurethane and/or polyurea unit and a film-forming polymer (B), the polymers (A) and (B) and the device being selected so as to obtain, at the device outlet, droplets of composition with average diameter less than 80 μm. The invention also concerns a hairstyling or hair-fixing method comprising the use of said devices and their use for making a hairstyling product.
US08691199B2	Ethylenic copolymers, compositions and methods of the same The present disclosure relates to novel ethylenic copolymers comprising from 10% to 80% by weight, of at least one monomer of polyethylene glycol (meth)acrylate type, from 20% to 90% by weight, of at least one anionic monomer, and from 0% to 70% by weight, at least one additional nonionic hydrophilic monomer. The disclosure also relates to a composition, such as cosmetic or pharmaceutical compositions, comprising the copolymers and to a method of using the same.
US08691198B2	Environmentally benign plasticizers based on derivatives of acetone Compounds derived from acetone are provided. Particularly, the compounds are derivatives of hydroxyacetone, including dimers of both 1-hydroxyacetone and 1,3-dihydroxyacetone. The hydroxy moieties on the core hydroxyacetone molecule serves as an attachment point for a variety of moieties (e.g., ethers, esters, phosphorous containing, or nitrogen containing) that are selected to provide the compound with a particular property. Applications of the compounds include plasticizers, supersurfactants, and additives for health care products, such as shampoo and perfume.
US08691193B2	Polycondensate, composition, treatment process, and preparation process Polycondensate, composition containing it, especially a nail varnish composition, and process for preparation. The polycondensate may be obtained by reacting: a polyol comprising 3 to 6 hydroxyl groups; a saturated or unsaturated non-aromatic monocarboxylic acid; an aromatic monocarboxylic acid containing 7 to 11 carbon atoms; and a saturated or unsaturated, or even aromatic, linear, branched and/or cyclic polycarboxylic acid, comprising at least two carboxylic groups COOH; and/or a cyclic anhydride of such a polycarboxylic acid.
US08691190B2	Oral care compositions with improved sweetness The present invention is directed to improved sweetener compositions and oral care compositions, especially those in the form of a toothpaste or oral/dental rinse, comprising the same. The sweetener composition comprises a combination of saccharin, sucralose and a rebaudioside, or sweeteners of similar sucrose equivalence and type, preferably in a ratio of about 1:about 1: about 2. The sweetener composition of the invention was found to significantly improve the taste profile, long lasting freshness and clean feel of oral care compositions and to deliver an in-use sweetness that was more natural and pleasant than artificial sweeteners alone.
US08691189B2	Method of colorectal cancer detection by using radiolabeled anti-GRP78 peptide The present disclosure describes techniques used for colorectal cancer detection. Position and distribution of colorectal cancer tumor are detected through nuclear imaging. Alternatively, stage of colorectal cancer is identified by shading value in tumor. Thus, the present disclosure provides a safe and noninvasive clinical method for diagnosing and tracing level and distribution of colorectal cancer before and after treatment.
US08691186B2	Imaging infection with compounds that bind to thymidine kinase The instant invention provides a method for diagnosing an infection in a subject by administering to the subject a compound suitable for imaging which binds to a thymidine kinase present in the infecting organism, and obtaining an image of the subject to determine the presence and location of the compound, wherein a localization of the compound is indicative that the subject has an infection.
US08691182B2	Ammonia flame cracker system, method and apparatus Apparatus, methods and systems reside in the decomposition of ammonia into a hydrogen gas mixture. An ammonia-rich gaseous mixture containing ammonia and oxygen enters into a conduit within which combustion and decomposition of the mixture is initiated, thereby liberating hydrogen. A mixture of gaseous products resulting from the reaction is expelled from the outlet of the conduit, the mixture including non-combusted hydrogen gas, which may then be used for other purposes. In the preferred embodiment, the incoming reactants including ammonia and oxygen are heat exchanged with the outgoing product mixture containing non-combusted hydrogen gas.
US08691180B2	Controlled placement and orientation of nanostructures A method for controlled deposition and orientation of molecular sized nanoelectromechanical systems (NEMS) on substrates is disclosed. The method comprised: forming a thin layer of polymer coating on a substrate; exposing a selected portion of the thin layer of polymer to alter a selected portion of the thin layer of polymer; forming a suspension of nanostructures in a solvent, wherein the solvent suspends the nanostructures and activates the nanostructures in the solvent for deposition; and flowing a suspension of nanostructures across the layer of polymer in a flow direction; thereby: depositing a nanostructure in the suspension of nanostructures only to the selected portion of the thin layer of polymer coating on the substrate to form a deposited nanostructure oriented in the flow direction. By selectively employing portions of the method above, complex NEMS may be built of simpler NEMSs components.
US08691179B2	Method for fabricating graphene sheets or graphene particles using supercritical fluid A method for fabricating graphene sheets or graphene particles includes (a) dispersing graphene oxide in an alcohol solution to prepare a graphene oxide dispersion solution, (b) reducing the graphene oxide dispersion solution under a supercritical condition to prepare graphene sheets or graphene particles, each of which is as a cluster of the graphene sheets, and (c) separating the graphene sheets or graphene particles, followed by washing and drying, and a method for fabricating a graphene film is configured to fabricate a graphene film in form of a thin film using the graphene sheets or graphene particles fabricated according to the method.
US08691177B2	High surface area carbon and process for its production The present invention provides a high surface area porous carbon material and a process for making this material. In particular, the carbon material is derived from biomass and has large mesopore and micropore surfaces that promote improved adsorption of materials and gas storage capabilities.
US08691176B2	Methods of producing carbonate minerals and apparatuses of producing the carbonate minerals In a method of producing carbonate mineral, a first aqueous solution containing an alkaline earth metal ion extracted from a cation exchange medium by a cation exchange reaction and carbon dioxide are added to a second aqueous solution to form a carbonate mineral.
US08691173B2	Composition for treatment of water The invention relates to a composition for treatment of water comprising rice husk ash and at least one bactericidal agent bonded to the rice husk ash. The bactericidal agent bonded to the rice husk ash is preferably silver and more particularly the bactericidal agent is nano silver. The invention also relates to a method of water purification using a composition comprising rice husk ash and at least one bactericidal agent bonded to the rice husk ash.
US08691168B2	Process for preparing a zinc complex in solution The present invention provides a process for preparing a solution of electrically uncharged [(OH)x(NH3)yZn]z where x, y and z are each independently 0.01 to 10, comprising at least the steps of (A) contacting ZnO and/or Zn(OH)2 with ammonia in at least one solvent in order to obtain a solution of electrically uncharged [(OH)x(NH3)yZn]z where x, y and z each independently 0.01 to 10 with a concentration c1, (B) removing some solvent from the solution from step (A) in order to obtain a suspension comprising Zn(OH)2, (C) removing solid Zn(OH)2 from the suspension from step (B), and (D) contacting the Zn(OH)2 from step (C) with ammonia in at least one solvent in order to obtain a solution of electrically uncharged [(OH)x(NH3)yZn]z where x, y and z are each independently 0.01 to 10 with the concentration c2, and to highly concentrated solutions of electrically uncharged [(OH)x(NH3)yZn]z where x, y and z are each independently 0.01 to 10, to a process for producing a layer comprising at least zinc oxide on a substrate, comprising at least the steps of (E) preparing a solution of electrically uncharged [(OH)x(NH3)yZn]z where x, y and z are each independently 0.01 to 10 by the former process according to the invention, (F) applying the solution from step (E) to the substrate and (G) thermally treating the substrate from step (F) at a temperature of 20 to 450° C. in order to convert electrically uncharged [(OH)x(NH3)yZn]z where x, y and z are each independently 0.01 to 10 to zinc oxide.
US08691167B2	Process for controlling carbonyl sulfide produced during chlorination of ores The present invention provides for a process for handling carbonyl sulfide waste and waste metal halides produced in industrial processes and, more particularly chlorination processes. The process includes the steps of hydrolyzing the carbonyl sulfide to produce a waste stream containing hydrogen sulfide and sulfidizing the resulting hydrogen sulfide containing stream with a solution of the waste metal halides. The resulting metal sulfide and metal halide-containing stream can be neutralized before disposal of the produced waste solids.
US08691164B2	Cell sorting system and methods Apparatus and Methods are provided for a microfabricated fluorescence activated cell sorter based on a switch for rapid, active control of cell routing through a microfluidic channel network. This sorter enables low-stress, highly efficient sorting of populations of small numbers of cells (i.e., 1000-100,000 cells). The invention includes packaging of the microfluidic channel network in a self-contained plastic cartridge that enables microfluidic channel network to macro-scale instrument interconnect, in a sterile, disposable format. Optical and/or fluidic switching forces are used alone or in combination to effect switching.
US08691163B2	Sample solution introduction kit and sample solution injector A sample solution introduction kit and a sample solution injector capable of introducing sample solution while reducing the rate of occurrence of an air bubble and having a simplified structure are proposed.A sample solution introduction kit includes a plate-like member and a sample solution injector. The plate-like member has a plurality of spaces formed therein and serving as reaction field and a communication space that communicates with the plurality of spaces therein and that has a portion defining an opening formed in a surface of the plate-like member, and the sample solution injector includes a container containing the sample solution, a tube that communicates with the bottom of the container and that is insertable into the opening, a stopper removably fitted into an opening formed at a top end of the tube, and liquid held in the container, and the liquid is insoluble in the sample solution and is lighter than the sample solution.
US08691161B2	Self-contained test sensor A test strip to assist in determining the concentration of an analyte in a fluid sample comprises a base, at least one tab and a break line. The base includes a capillary channel and a test element. The capillary channel is in fluid communication with the test element. The test element is adapted to receive the fluid sample. The at least one tab is removably attached to the base. The capillary channel extends from the base into a portion of the tab. The break line intersects the capillary channel in which an inlet to the capillary channel is exposed along the break line when the tab is separated from the base.
US08691160B2	Sample analysis disc and method of producing sample analysis disc A sample analysis disc has concave sections and convex sections formed alternately in a track area of a disc surface. Labeled beads are immobilized to the track area. Each labeled bead has a biopolymer bound thereto. Only one of the labeled beads is allowed to be filled in each concave section.
US08691157B2	Honeycomb structure and exhaust gas converter A honeycomb structure includes at least one honeycomb unit. The at least one honeycomb unit has a plurality of through holes defined by partition walls along a longitudinal direction of the honeycomb unit. The honeycomb unit includes zeolite, an inorganic binder, and a noble metal catalyst. The noble metal catalyst is supported in a region of the honeycomb unit. The region extends from one end portion of the honeycomb unit in the longitudinal direction over approximately 1.5% or more to approximately 20% or less of an overall length of the honeycomb unit in the longitudinal direction.
US08691156B2	Preferential oxidation reactor and fuel cell system using the same A preferential oxidation reactor for removing carbon monoxide in a hydrogen mixture gas is disclosed. The preferential oxidation reactor may include a housing having a catalytic layer provided therein, a mixture gas supply portion inserted into the interior of the housing and penetrating the catalytic layer, a condensate receiving portion contained within the housing and in fluid communication with a gas outlet port of the mixture gas supply portion and condensate control tubes arranged in the catalytic layer of the housing and in fluid communication with the condensate receiving portion. The condensate control tubes may have a capillary structure. A fuel cell system including the preferential oxidation reactor is also disclosed.
US08691155B2	Hydrocarbon conversion apparatus including fluid bed reaction vessel and related processes Embodiments of a hydrocarbon conversion apparatus are provided, as are embodiments of a hydroprocessing conversion process. In one embodiment, the hydrocarbon conversion apparatus includes a reaction vessel having a reaction chamber and a feed distribution chamber. A riser fluidly couples the feed distribution chamber to the reaction chamber, and a catalyst recirculation standpipe fluidly couples the reaction chamber to the feed distribution chamber. The catalyst recirculation standpipe forms a catalyst recirculation circuit with the reaction chamber, the feed distribution chamber, and the riser. A catalyst is circulated through the catalyst recirculation circuit during operation of the hydrocarbon conversion apparatus.
US08691151B2	Opto-fluidic architecture for particle manipulation and sorting This invention provides an apparatus for particle sorting, particle patterning, and methods of using the same. The sorting or patterning is opto-fluidics based, in that particles are applied to individual chambers in the device, detection and/or analysis of the particles is carried out, such that a cell or population whose removal or conveyance is desired is defined, and the cell or population is removed or conveyed via application of an optical force and flow-mediated conveyance or removal of the part.
US08691150B2	System for determining a number of unused consumable elements for testing a bodily fluid sample The invention relates to a system for testing a sample of bodily fluid, comprising a carrier band, which carries a plurality of consumable elements, wherein one end of the carrier band is attached to a wind-up device for winding the carrier band, together with used consumable elements, onto a reel for the band transport, and comprising a display for displaying information regarding the supply of yet unused consumable elements of the carrier band. According to the invention, it is provided that information regarding the supply of yet unused consumable elements of the carrier band is obtained from an angle of rotation and from a band transport length by which the carrier band is moved with a rotation of the reel about said angle of rotation.
US08691148B2	Sample dispensing apparatus and automatic analyzer including the same The invention provides a small-sized automatic analyzer being compact, enabling a large number of analysis items to be carried out, and having a high processing speed. The automatic analyzer is particularly suitably applied to a medical analyzer used for qualitative/quantitative analysis of living body samples, such as urine and blood. A plurality of sample dispensing mechanism s capable of being operated independently of each other are provided to suck a sample from any one of a plurality of sample suction positions and to discharge the sucked sample to any one of a plurality of positions on a reaction disk. The automatic analyzer having a high processing capability can be thus realized without increasing the system size.
US08691147B2	Apparatus for processing a sample in a liquid droplet and method of using the same The invention provides an apparatus and a method of processing a biological and/or chemical sample in a liquid droplet. The apparatus comprises a processing compartment, which is defined by a reservoir and an immobilization member. The processing compartment is further adapted to accommodate a medium, which is immiscible with the liquid droplet, and of a lower surface energy than the liquid of the liquid droplet. The reservoir is defined by a circumferential wall and a base. The immobilization member is arranged within the reservoir and comprises a surface that is patterned in such a way that it comprises at least one predefined immobilization area. The predefined immobilization area within the patterned surface is of a higher surface energy than the medium. The liquid droplet is disposed onto the predefined immobilization area, whereby the liquid droplet is immobilized thereon via hydrophilic-hydrophilic or hydrophobic-hydrophobic interactions.
US08691146B2	Electron beam sterilization method To provide an efficient sterilization method for inexpensively sterilizing a medical article having a complex shape such as a body fluid treatment device of a generally-called dry or semi-dry type by so applying an electron beam that the overall absorbed dose distribution is small and to provide its application package form. [MEANS FOR SOLVING PROBLEMS] A method for sterilizing tubular body fluid treatment devices of a dry or semi-dry type contained in an electron beam-transmitting case with an electron beam. The method is characterized in that a stack structure which includes a gap layer having an average density of 0.010 to 0.180 g/cm3 and two body fluid treatment device layers having an average density of 0.050 to 0.200 g/cm3 and sandwiching the gap layer is contained in the electron beam-transmitting case, and the case is irradiated with the electron beam.
US08691143B2	Lead-free solder alloy A lead-free solder alloy is provided which has improved impact resistance to dropping even after thermal aging and which is excellent with respect to solderability, occurrence of voids, and yellowing. A solder alloy according to the present invention consists essentially of, in mass percent, (1) Ag: 0.8-2.0%, (2) Cu: 0.05-0.3%, (3) at least one element selected from In: at least 0.01% and less than 0.1%, Ni; 0.01-0.04%, Co: 0.01-0.05%, and Pt: 0.01-0.1%, optionally (4) at least one element selected from Sb, Bi, Fe, Al, Zn, and P in a total amount of up to 0.1%, and a remainder of Sn and impurities.
US08691140B2	Process for injection molding of thin-walled preform An injecting/blowing device includes a mold for injecting a thin-walled hollow preform capable of being transformed into a more voluminous hollow body. The mold includes a counter mold defining a cavity, a cure located in the cavity, and a preform impression located between the counter mold inner surface and the core which will receive the melt, at least two main preferential flow channels or at least two secondary preferential flow channels having a recessed zone at the surface of the core and the inner surface of the cavity. The main flow channels are located only at the impression zone corresponding to the zone for transforming the perform, and in the optional secondary flow channels are flow channels discontinuous from the main flow channel.
US08691139B2	Component mounting arrangement A method of connecting a component to a molded article may include disposing a component adjacent to a wall of the article being molded, overlapping a portion of the component with a portion of the wall of the article being molded while the wall is still at least partially molten, and permitting the wall of the article being molded to cool with said portion of the component still overlapped by the wall. Preferably, a portion of the component is overlapped on two sides by the wall of the article being molded to firmly retain the component relative to the article after the article is formed. The article may be a receptacle, or any other object, as desired.
US08691134B2	Roll-to-roll imprint lithography and purging system Droplets of polymerizable material may be patterned on a film sheet using a roll-to-roll system. The droplets of polymerizable material may be dispensed on the film sheet such that a substantially continuous patterned layer may be formed on the film sheet. A contact system provides for smooth fluid front progression the polymerizable material during imprinting. A gas purging system may be positioned during imprinting. Gas purging systems may provide for purging in parallel as fluid front of polymerizable material moves through roll-to-roll system.
US08691133B2	Recyclable plastic composite wheel rim fabrication method A recyclable plastic composite wheel rim fabrication method includes the steps of: (a) preparing a triaxle or biaxle composite fabric, (b) coating the composite fabric with a layer of plastic material to form a composite substrate, (c) processing the composite substrate into a composite plate member by means of roller pressing, dipping, bake-drying and cutting, (d) stamping the composite plate member into a blank wheel rim by means of a hot press, (e) cooling the blank wheel rim and trimming it to remove to remove blurs and defective selvedge, and (f) polishing the surface of the blank wheel rim to obtain a finished wheel rim.
US08691132B2	Heat treatment of thin polymer films Stretch film is treated by passing a web of tackifier-containing, unbloomed thin polymer film through a heater so that the web is heated to a temperature sufficient to cause tackifier bloom prior to the web reaching a next stage in an in-line process. Also, a pattern can be applied to a thin polymer film. An oriented web of thin polymer film is passed across at least one heated roller having the pattern engraved thereon to define face regions and relief regions collectively conforming to the pattern. As the web contacts each roller surface, portions of the web positioned over the relief regions receive less heat than portions of the web positioned over the face regions, thereby causing the respective portions of the web to undergo differential, heat-induced shrinkage which imparts the pattern to the thin polymer film.
US08691130B2	Process of making water-dispersible multicomponent fibers from sulfopolyesters Disclosed are multicomponent fibers derived from a blend of a sulfopolyester with a water non-dispersible polymer wherein the as-spun denier is less than about 6 and wherein the water dispersible sulfopolyester exhibits a melt viscosity of less than 12,000 poise measured at 240° C. at a strain rate of 1 rad/sec, and wherein the sulfopolyester comprising less than about 25 mole % of residues of at least one sulfomonomer, based on the total moles of diacid or diol residues. The multicomponent fiber is capable of being drawn at a relatively high fiber speed, particularly at least about 2000 m/min, and may be used to produce microdenier fibers. Fibrous articles may be produced from the multicomponent fibers and microdenier fibers. Also disclosed is a process for multicomponent fibers, nonwoven fabrics, and microdenier webs.
US08691129B2	Method of producing exfoliated graphite composite compositions for fuel cell flow field plates A method of producing an electrically conductive composite composition, which is particularly useful for fuel cell bipolar plate applications. The method comprises: (a) providing a supply of expandable graphite powder; (b) providing a supply of a non-expandable powder component comprising a binder or matrix material; (c) blending the expandable graphite with the non-expandable powder component to form a powder mixture wherein the non-expandable powder component is in the amount of between 3% and 60% by weight based on the total weight of the powder mixture; (d) exposing the powder mixture to a temperature sufficient for exfoliating the expandable graphite to obtain a compressible mixture comprising expanded graphite worms and the non-expandable component; (e) compressing the compressible mixture at a pressure within the range of from about 5 psi to about 50,000 psi in predetermined directions into predetermined forms of cohered graphite composite compact; and (f) treating the so-formed cohered graphite composite to activate the binder or matrix material thereby promoting adhesion within the compact to produce the desired composite composition. Preferably, the non-expandable powder component further comprises an isotropy-promoting agent such as non-expandable graphite particles. Further preferably, step (e) comprises compressing the mixture in at least two directions. The method leads to composite plates with exceptionally high thickness-direction electrical conductivity.
US08691128B2	Expansion injection molding process and mold for expansion injection molding To provide an expansion injection molding process, which is freed from the occurrence of swirl marks on the surface of a molded article and by which foamed injection moldings having good appearance can be produced in a short molding cycle and at a low cost; and a mold for expansion injection molding.A movable mold 2 is moved toward a fixed mold 1, whereby a sealing member 6 set on at least one of a pair of facing surfaces of the mold 1 and mold 2 in the outside of a cavity is brought into contact with the other of the facing surfaces or a sealing member 6 set thereon to make the cavity 3 gas-sealed state. While keeping the gas-sealed state, the movable mold 2 is further moved toward the fixed mold 1 with the sealing member 6 compressed, whereby the volume of the cavity 3 is decreased to enhance the pressure in the cavity 3 to a level exceeding the atmospheric pressure. Then, a thermoplastic resin is injected into the cavity 3 of an enhanced pressure.
US08691126B2	Method of fabricating an injection molded component A method of fabricating a foamed, injection-molded component is provided. The method includes the step of introducing a liquid, a nucleating agent and a polymer into an injection barrel of an injection molding machine. The liquid, the nucleating agent and the polymer are injected into a mold corresponding in shape to the component and the component is released from the mold.
US08691124B2	Alignment and imprint lithography An imprint lithography alignment apparatus is disclosed that includes at least two detectors which are configured to detect an imprint template alignment mark, wherein the alignment apparatus further comprises alignment radiation adjustment optics which are configured to provide adjustment of locations from which the at least two alignment detectors receive alignment radiation.
US08691123B2	Fine processing method, fine processing apparatus, and recording medium with fine processing program recorded thereon According to one embodiment, a fine processing method includes determining a resist amount required for each first region of a pattern formation surface and a total amount of resist. The method include dividing the total amount of resist by a volume of one resist drop to determine the resist drops total number. The method include determining a provisional position for the resist drop of the total number. The method include assigning the each first region to nearest one resist drop, and partitioning again the pattern formation surface into second regions assigned to the each resist drop. The method include determining a divided value by dividing the volume of the one resist drop by the required total amount of resist determined. The method include finalizing a final position of the each resist drop, if a distribution of the divided value in the pattern formation surface falls within a target range.
US08691122B2	Multi-colored shaped body The present invention relates to a multi-colored shaped body having layers arranged on top of one another for producing dental restorations, a process for its production and its use for the manufacture of dental restorations.
US08691121B2	Sulfur granulator system and method Sulfur (or sulphur) spray nozzles disposed with a tank spray liquid molten sulfur into the cooling liquid in the tank. Solid sulfur seeds are formed in the cooling liquid and settle in the tank. The tank may be a spiral dewaterer tank that has a screw conveyor at the bottom of the tank that moves the seeds to a granulating drum for enlargement into sulfur granules. The tank may also be used to capture and remove sulfur dust from a slurry of sulfur dust and water recycled from the granulating drum. The sulfur dust in the cooling tank may be captured by contact with molten sulfur droplets streaming down the cooling liquid column such that the dust particles become incorporated into the droplet, thereby being converted to seed. The granulating drum may be equipped with two or more sets of segmented lifting flights. The sets of flights may not be in alignment. The flights may be spaced apart from the inside surface of the drum with segmented rib members. The rib members may allow for the movement of sulfur seeds and granules between the flights and the inside surface of the drum as the drum rotates.
US08691120B2	Chromene compound A photochromic chromene compound having an indeno(2,1-f)naphtho(1,2-b)pyran structure as its basic skeleton, an aryl group or a heteroaryl group at the 6-position carbon atom of the structure and an electron donor group having a Hammett constant σp of not more than −0.1 at the 7-position carbon atom.
US08691119B2	Thick film paste containing lead-tellurium-lithium-titanium-oxide and its use in the manufacture of semiconductor devices The present invention is directed to an electroconductive thick film paste composition comprising electrically conductive Ag, a second electrically conductive metal selected from the group consisting of Ni, Al and mixtures thereof and a lead-tellurium-lithium-titanium-oxide all dispersed in an organic medium. The present invention is further directed to an electrode formed from the thick film paste composition and a semiconductor device and, in particular, a solar cell comprising such an electrode.
US08691118B2	Conductive metal ink composition and method for forming a conductive pattern The present invention relates to a conductive metal ink composition which is properly applied for roll-printing process to form conductive pattern with improved conductivity, and the method of preparing a conductive pattern using the same.The conductive metal ink composition comprises a conductive metal powder; an organic silver complex where an organic ligand including amine group and hydroxyl group binds with a silver (Ag) salt of aliphatic carboxylic acid; a non-aqueous solvent comprising a first non-aqueous solvent having a vapor pressure of 3 torr or lower at 25° C. and a second non-aqueous solvent having a vapor pressure of higher than 3 torr at 25° C.; and a coatability improving polymer.
US08691115B2	System and method for controlling char in biomass reactors A system and process for modulating the carbon content of ash produced by a biomass gasification process, for example, to selected levels chosen by an operator, through the controlled injection of steam and controlled introduction of warm air during processing of a biomass feedstock. The system and process include delivering a carbon-containing biomass feedstock to a gasification reactor and producing a syngas and an ash from the biomass feedstock, and regulating the carbon content of the ash between a level at which carbon not present in the ash and a second level at which carbon is present in the ash. The regulating step entails selectively decreasing the moisture level of the biomass feedstock prior to the biomass feedstock being delivered to the gasification reactor and thereby increasing the carbon content of the ash, or increasing a moisture level of a mixture of the biomass feedstock, ash and gases within the gasification reactor and thereby decrease the carbon content of the ash.
US08691113B2	Red phosphor, method for producing red phosphor, white light source, illuminating device, and liquid crystal display device A compound is provided containing silicon, aluminum, strontium, europium, nitrogen, and oxygen is used that enables a red phosphor having strong luminous intensity and high luminance to be obtained, and that enables the color gamut of a white LED to be increased with the use of the red phosphor. The red phosphor contains an element A, europium, silicon, aluminum, oxygen, and nitrogen at the atom number ratio of the following formula: [A(m−x)Eux]Si9AlyOnN[12+y−2(n−m)/3]. The element A in the formula is at least one of magnesium, calcium, strontium, and barium, and m, x, y, and n in the formula satisfy the relations 3
US08691111B2	Tetraoxybiphenyl ester chiral dopants for cholesteric liquid crystal displays A liquid crystal composition comprising a chiral dopant compound represented by the following formula: wherein: R1, R2 are independently aryl, alkyl, alkenyl, cycloalkyl, alkoxyaryl, alkaryl or heterocyclic all either substituted or unsubstituted, or combine to form a carbocyclic or heterocyclic ring; R3 and R4 are independently hydrogen, halogen, cyano, alkoxy, NHCOR7, NHSO2R7, COOR7, OCOR7, aryl, alkyl, alkenyl, cycloalkyl, alkoxyaryl, alkaryl or heterocyclic all either substituted or unsubstituted, or combine with either R1 or R2 to form a carbocylic or heterocyclic ring; R5 and R6 are independently hydrogen, CH2, CH, alkyl or aryl either substituted or unsubstituted, COOR7, or combine with L to form a carbocyclic or heterocyclic ring; R7 is aryl, alkyl, alkenyl, cycloalkyl, alkoxyaryl or heterocyclic all either substituted or unsubstituted; L is the non-metallic elements required to form a carbocyclic or heterocyclic ring, or a single bond or a double bond; m is 1-3; n is 0-12.
US08691110B2	Coolant composition for fuel cell A coolant composition for a fuel cell, including (a) an alkylene glycol, (b) deionized water, and (c) a compound containing a trimethylsilyl group. The compound containing a trimethylsilyl group of the composition of the present invention prevents the oxidation of the alkylene glycol, and thus the generation of an acid is 700 ppm or less. Additionally, the compound prevent the oxidation of the alkylene glycol, thereby inhibiting the generation of an ionic material, and thus the rate of change of electrical conductivity (conductivity after oxidation/initial conductivity) can be maintained to be 40 times or less. Therefore, the coolant composition for a fuel cell of the present invention can be used as a coolant for a cooling system of a fuel cell driving device with an electrical conductivity of 40 μs/cm or less even without being frozen in the winter.
US08691105B2	Method of detecting contamination of titanium alloys of two-phase type having an alpha and a beta phase A method of examining a titanium alloy with an alpha phase and a beta phase is disclosed. The method includes: cutting a sample of a part made of the alloy; preparing a region of the cut surface of the sample situated in the vicinity of the edge of the sample, the edge being in common with the outside surface of the part; observing the alpha phase of the region at a magnification of greater than ×5000; deciding on whether granularity is present or absent in the alpha phase of a first zone contiguous with the edge of the sample; and concluding that the alloy has been contaminated with a gas if granularity is found to be absent in the alpha phase of the contiguous zone whereas granularity is present in the alpha phase outside the contiguous zone.
US08691104B2	Nanotextured surfaces and related methods, systems, and uses A method of controlling wetting characteristics is described. Such method includes forming and configuring nanostructures on a surface where controlling of the wetting characteristics is desired. Surfaces and methods of fabricating such surfaces are also described.
US08691103B2	Surface profile adjustment using gas cluster ion beam processing A method of treating a workpiece is described. The method comprises computing correction data from metrology data related to a workpiece surface profile, adjusting the surface profile in accordance with the correction data using a gas cluster ion beam (GCIB), and further adjusting the surface profile by performing an etching process following the GCIB adjustment.
US08691101B2	Method for manufacturing ejection element substrate A method for manufacturing an ejection element substrate, which is provided with a flow-channel-forming member having an ejection orifice for ejecting a liquid and a liquid flow channel that is communicated with the ejection orifice, a substrate having a supply port for supplying the liquid to the liquid flow channel, and a filter structure formed in the bottom of the supply port, includes: forming the supply port by forming a through-hole by etching the substrate from a second face of the substrate on the side opposite to a first face of the substrate, on which the flow-channel-forming member is disposed; providing a resinous protection film on the side face and the bottom of the supply port; and forming a minute opening in the resinous protection film in the bottom of the supply port by carrying out a laser processing from the side of the second face.
US08691100B2	Concave and convex micromirrors and methods of making the same A method comprising providing a first substrate and forming a first sacrificial layer over the first substrate, the first sacrificial layer comprising a curved surface portion, and forming a curved micromirror by depositing a reflective material over at the curved surface portion.
US08691098B2	Porous web, particularly for filtration of biological fluids A porous web for filtering fluids has a plurality of adjacent layers of fiber material having anisotropic properties. The anisotropic directions of a given vectorial property of at least two adjacent layers differ one from the other by an angle greater than 0°, and preferably of at least 8°. The porous web is particularly useful as a filter element for the filtration of biological fluids, such as blood and blood components.
US08691096B2	Oil filters containing strong base and methods of their use Novel filter elements for sequestering acids from oil or fuel, the strong base flocs that comprise the filter elements, and methods of their preparation and use are disclosed. The filter elements comprise a mechanically linked interlocking fiber matrix interspersed with strong base particle flocs wherein the strong base particles constitute at least 30% by weight of the filter element. Certain filter elements may be useful for sequestering acids or neutralized acids in certain oils or fuels, for example, the acids originating in the combustion and lubrication system of an internal combustion engine or those contained in oils in an oil circulation system. Other filter elements may be useful for reducing oxidation of an oil.
US08691094B2	Method and system for treating domestic sewage and organic garbage A method and system for treating domestic sewage and organic garbage are provided. The method comprises the steps of: multi-phase separation, retting, generating sewage gas, and optional biological denitrification and dephosphorization, which can convert the domestic sewage and organic garbage into clear water, sewage gas, organic manure and sludge. The system comprises a multi-phase separation device, a retting device, a sewage gas generating device and a biological denitrification and dephosphorization device, which can treat the domestic sewage and organic garbage effectively and environmental friendly to achieve a reduction in pollution emission.
US08691092B2	Treating water using floating wetland made of plastic waste An apparatus for creating floating wetlands and improving water quality is provided. The apparatus includes a lower retainer; an upper retainer; a floatable waste material disposed between the lower retainer and the upper retainer; and an organic material planted between the lower retainer and the upper retainer; wherein the organic material is configured to denitrify the water source. A method of making a floating wetland device is also provided.
US08691088B2	Narrow I.D. monolithic capillary columns for high efficiency separation and high sensitivity analysis of biomolecules A method of preparing an ultra-nanoscale-LC monolithic separation medium for use in capillary columns, or channels in microfabricated devices (microchips), and capillaries prepared by the method are disclosed. The application of moderate positive pressure to both ends of the capillary during the monolith polymerization process permits the preparation of monolithic capillary columns having very low i.d., e.g., 25 μm and smaller, with enhanced mass transfer properties and low back pressures, and excellent column-to-column reproducibility of retention times.
US08691085B2	Oil filtering device The present invention relates to a filtering device, which comprises a base plate (12) having a threaded center hole (122); a filter housing (11) having a cap-shaped body coupleable to the base plate; an anti-drainback valve (15) having a valve hole (151) defined in the center portion thereof arranged on the base plate (12), where the valve hole (151) correspondingly aligns with the threaded center hole (122) of the base plate (12); a filter assembly (14) having a filter hole (1411) abutting on the anti-drainback valve (15), where the filter hole (1411) aligns with the valve hole (151) of the anti-drainback valve (15); and a bypass valve (13) having a central plate portion (132) and a pair of extending wing portions (131) pressingly arranged between the inner surface of the filter housing and the filter assembly. The separately removable housing (11) provides easy assembly and enables simple filter media replacement.
US08691081B2	Process for contacting hydrocarbon feed and catalyst A process for distributing a deflecting media into an axial center of a riser to push catalyst outwardly toward the feed injectors ensures better contacting between hydrocarbon feed and catalyst.
US08691079B2	Compression reactor and process for hydroprocessing The present invention is directed to a process for hydroprocessing of a liquid hydrocarbon feedstock, comprising: (a) mixing liquid, partially vaporized and/or vaporized hydrocarbon feedstock with molecular hydrogen; (b) feeding said mixture into a compression reactor; (c) compressing said mixture to a pressure, a temperature and for a residence time sufficient to: i) thermally crack at least a portion of hydrocarbon molecules in said hydrocarbon feedstock, and ii) react hydrogen in the presence of a hydrogenation catalyst with unstable portions of the cracked molecules, forming a hydroprocessed product; and (d) expanding said mixture to reduce the pressure and temperature thereby reducing subsequent undesirable reactions.
US08691077B2	Process for converting a hydrocarbon stream, and optionally producing a hydrocracked distillate One exemplary embodiment can be a process for converting a hydrocarbon stream. The process can include passing the hydrocarbon stream having one or more C40+ hydrocarbons to a slurry hydrocracking zone to obtain a distillate hydrocarbon stream having one or more C9-C22 hydrocarbons, and passing the distillate hydrocarbon stream to a hydrocracking zone for selectively hydrocracking aromatic compounds including at least two rings obtaining a processed distillate product.
US08691076B2	Process for manufacturing naphthenic base oils from effluences of fluidized catalytic cracking unit Disclosed is a method of manufacturing high-quality naphthenic base oil by subjecting, as a feedstock, light cycle oil (LCO) and slurry oil (SLO) obtained through fluidized catalytic cracking (FCC) to hydrotreating and dewaxing.
US08691072B2	Method for measuring hematocrit value of blood sample, method for measuring concentration of analyte in blood sample, sensor chip and sensor unit Voltage is applied across a counter electrode and a working electrode, with which a blood sample is in contact, in such a state that an oxidant in a redox substance is not substantially in contact with a working electrode but is in contact with a counter electrode and a reductant is not substantially in contact with the counter electrode but is in contact with the working electrode, whereby the reductant and the oxidant are respectively oxidized and reduced to measure current produced upon the oxidation and reduction. According to the above constitution, while lowering the voltage applied across the working electrode and the counter electrode, the Hct value of the blood sample can be measured stably with a satisfactory detection sensitivity. This measurement can be carried out with a sensor chip comprising a working electrode (11), a counter electrode (12), and a blood sample holding part (14) having branch parts (18a, 18b). A first reagent (13) consisting essentially of an oxidant in a redox substance is disposed in contact with the surface of a counter electrode which faces the branch part (18b), and a second reagent (19) consisting essentially of a reductant is disposed in contact with the surface of a working electrode that faces the branch part (18a).
US08691065B2	Efficient interface between electrochemical sensor and computer A system includes one or more electrochemical sensors. Each sensor includes at least two electrodes. The system also includes an interface configured to provide communication between the one or more electrochemical cells and a computer. The interface includes a circuit board with plurality of sensor circuits. Each sensor circuit is configured to operate a different electrochemical sensor and includes a plurality of electrode lines that are each configured to be in communication with a different electrode on an electrochemical sensor.
US08691064B2	Sputter-enhanced evaporative deposition apparatus and method A deposition apparatus includes a deposition source that produces a deposition flow of a deposited material and has an evaporation source with a material to be deposited therein, and a sputtering source that produces sputtering ions directed at the material to be deposited in the evaporation source. A deposition target is in facing relationship to the deposition source. The sputtering source is operated simultaneously with the evaporation source.
US08691063B2	Methods and apparatus for forming diamond-like coatings The invention is an apparatus and method for depositing a coating onto a substrate. The apparatus includes a vacuum chamber with an inlet for supplying a precursor gas to the chamber. The chamber includes a carrier for locating the substrate in the chamber, a first anode having an aperture in which plasma can be formed, and a magnetic field source. The substrate, when located in the carrier, constitutes a first cathode. When a substantially linear magnetic field between the anode and the cathode is formed, the direction of the magnetic field is substantially orthogonal to the surface to be coated and plasma production and deposition takes place substantially within the linear magnetic field.
US08691061B2	Electrode device for an electrochemical sensor chip An electrode device for an electrochemical sensor chip includes an insulation sheet having an insulating property and including a top surface and a bottom surface opposite to each other in a thickness direction, and electrode members having a conductivity and held by the insulation sheet with the electrode members piercing the insulation sheet in a thickness direction, one ends of the electrode members located on the top surface side of the insulation sheet being connected to an analyte, the other ends located on the bottom surface side of the insulation sheet being connected to an electrodes of a transducer.
US08691058B2	Apparatus for sputtering and a method of fabricating a metallization structure A method of depositing a metallization structure (1) comprises depositing a TaN layer (4) by applying a power supply between an anode and a target in a plurality of pulses to reactively sputter Ta from the target onto the substrate (2) to form a TaN seed layer (4). A Ta layer (5) is deposited onto the TaN seed layer (4) by applying the power supply in a plurality of pulses and applying a high-frequency signal to a pedestal supporting the substrate (2) to generate a self-bias field adjacent to the substrate (2).
US08691057B2	Stress adjustment in reactive sputtering In a dual cathode magnetron, an adjustment circuit is provided between a pair of sputter targets having a coaxial (preferably frusto-conical) relationship to modify the distribution of ion and electron currents flowing from the plasma discharge to a substrate residing within a sputter chamber. A stress adjustment circuit is used to modify the ion bombardment of the growing films on the substrate resulting in a mechanism for control of the stress in the deposited films. In a preferred embodiment, the adjustment circuit comprises a variable resistor disposed between an internal shield that acts as a passive anode and a target. The value of the variable resistor influences the plasma discharge current distribution between the split sputter targets and the internal shields, and can effectively be used to adjust the properties of the deposited films.
US08691051B2	Security paper material, in particular for labelling and packaging, and manufacturing method thereof A manufacturing method of a security paper material, in particular for labelling and packaging, comprising the steps of forming a paper sheet from a wet cellulose fiber pulp and providing the paper sheet with electronic chips; the chips are introduced into the paper sheet being formed during the transformation step of the pulp into paper and are deposited directly onto the wet pulp and at least partially embedded in the pulp. Optionally, an auxiliary paper sheet is coupled to the paper sheet provided with the chips so that the chips are incorporated between the two sheets.
US08691049B2	Method for an energy efficient production of cellulose pulp in a continuous digester The method is for the production of cellulose pulp in a continuous digester system. Chips are impregnated in an impregnation vessel. The chips are then fed to a subsequent digester vessel in a transfer fluid. A black liquor withdrawal is taken from the digester, which withdrawal is led to the bottom to heat the chips before the chips are fed out from the impregnation vessel. A transfer fluid is withdrawn from the digester and led to the impregnation vessel to act as an impregnation fluid. At least a portion of the transfer fluid that was withdrawn from the top of the digester passes an indirect heat exchanger, in which the transfer fluid withdrawn from the top of the digester at a temperature of at least 125° C. exchanges heat indirectly with a first fluid for the production of steam from the first fluid.
US08691046B2	Energy-activated room temperature-pumpable polymer compositions and devices for activating and dispensing the same Energy-activated room temperature-pumpable polymer compositions, devices for activating and processing the same into solid cellular or non-cellular polymeric materials that can be used as adhesives, sealants, coatings or gasket materials, and methods of making and using the same. The compositions according to the invention include solid particles that include one or more polymers, which are emulsified, dispersed or suspended in a liquid carrier together with at least one processing aid, such as a reactive blowing agent, a low molecular weight surfactant, a high molecular weight surfactant, one or more compounds found in latex paint, starch, cellulosic derived products and combinations of two or more thereof. The processing aids provide various benefits including, for example, reduced density, improved process hygiene, improved foam stability, faster bonding times and/or lower processing temperatures.
US08691045B2	Positioning device and positioning method for two-sided adhesive tapes A positioning device for positioning a number of two-sided adhesive pieces includes a base, a number of pulling blocks, and a pressing block. The base includes a positioning block defining a number of positioning holes. Each pulling block includes a connecting plate, and a supporting plate protruding out from a top end of the connecting plate. A first surface of each adhesive piece is adhered on a top surface of one of the supporting plate. The connecting plate is received in a corresponding one of the positioning hole. The pressing block is attached to the positioning block. A second surface of each adhesive piece to be adhered to a bottom surface of the pressing block.
US08691042B2	Eco anti-mold fresh-keeping chip An eco anti-mold fresh-keeping chip, a graph layer is formed on a base material after printed and a lustering film polyester layer is pasted on the graph layer by a manufacturing machine to construct a chip body, the chip body is put inside the fumigation trough with natural anti-mold fresh keeping anti-oxidation material, the chip body absorbs the natural anti-mold fresh-keeping anti-oxidation material to form an eco anti-mold fresh-keeping chip after the fumigation and permeation procedure in chamber, the main component of the natural anti-mold fresh-keeping anti-oxidation material is consisted of Allyl isothiocyanate and eucalyptol (juniper pythoncidere).
US08691039B2	Method and device for thermocompression bonding There are provided a method and device for thermocompression bonding of possibly preventing any warping of a resin member to be caused by thermocompression bonding, and of possibly reducing the time to be taken for processing. The method for thermocompression bonding, includes: preheating a resin member using an infrared radiation section; and subjecting the resin member to thermocompression bonding using a heating section and a pressurization section.
US08691036B2	Method of making a reusable hose bundling sleeve A reusable hose bundling sleeve is provided that is made of a tightly-woven nylon material coated with urethane. Strips of hooks and loops are adhered and stitched to opposite ends of opposite sides of the sleeve. The reusable hose is installed by wrapping the sleeve around the hoses or cables such that the strips of hooks and loops align and engage. Notches can be cut along the length of the reusable hose bundling sleeve to allow for shorter hoses or cables within the sleeve to exit. Because of the materials used, the notches will not weaken the fibers and cause fraying. The reusable hose bundling sleeve is removed by separating the strips of hooks and loops and unwrapping the sleeve. The reusable hose bundling sleeve can be installed, removed, and reinstalled quickly and without diminishing durability. Alternatively, the sleeve may be adapted to be secured and/or hanged.
US08691035B2	Method of making medical tubing having variable characteristics using thermal winding An efficient and cost-effective method of manufacturing a kink-resistant tube, wherein a coated wire is wound around a mandrel while simultaneously being heated to melt the coating, is provided.
US08691030B2	Low alloy steels with superior corrosion resistance for oil country tubular goods The present application describes a steel composition that provides enhanced corrosion resistance. This steel composition includes one of vanadium in an amount of 1 wt % to 9 wt %, titanium in an amount of about 1 wt % to 9 wt %, and a combination of vanadium and titanium in an amount of 1 wt % to about 9 wt %. In addition, the steel composition includes carbon in an amount of 0.03 wt % to about 0.45 wt %, manganese in an amount up to 2 wt % and silicon in an amount up to 0.45 wt %. In one embodiment, the steel composition includes a microstructure of one of the following: ferrite, martensite, tempered martensite, dual phase ferrite and martensite, and dual phase ferrite and tempered martensite. Further, the present application describes a method for processing the steel composition and use of equipment such as oil country tubular goods, fabricated with the steel composition.
US08691029B2	Reduced ferrite steel liner A steel liner with a case comprising at least 95% martensite, such as substantially 100% martensite, and a core comprising pearlite and discrete ferrite grains decorating former austenite grain boundaries. The ferrite in the liner's core has an average size of less than about 25 μm.
US08691028B2	Article having a hexavalent-chromium-free, corrosion-inhibiting organic conversion coating thereon, and its preparation A method for protecting a surface of an article includes preparing or otherwise providing a reactive solution of a form of polyaniline and an acid, thereafter applying the reactive solution to the surface of the article to form an adherent conversion coating on the surface, thereafter oxidizing the adherent conversion coating to form an oxidized coating, and thereafter contacting a chromate-free, corrosion inhibiting organic compound such as a salt of a dithiocarbamate or a salt of a dimercaptothiadiazole to the oxidized coating to form a fixed conversion coating on the surface of the article. The resulting article has the fixed conversion coating adhered to the surface of the article. The fixed conversion coating has a mixture of a reduced polyaniline salt, and a fixed disulfur-linked dithiocarbamate polymer or dimer.
US08691027B2	Method for removing material from semiconductor wafer and apparatus for performing the same A pressure is maintained within a volume within which a semiconductor wafer resides at a pressure that is sufficient to maintain a liquid state of a precursor fluid to a non-Newtonian fluid. The precursor fluid is disposed proximate to a material to be removed from the semiconductor wafer while maintaining the precursor fluid in the liquid state. The pressure is reduced in the volume within which the semiconductor wafer resides such that the precursor fluid disposed on the wafer within the volume is transformed into the non-Newtonian fluid. An expansion of the precursor fluid and movement of the precursor fluid relative to the wafer during transformation into the non-Newtonian fluid causes the resulting non-Newtonian fluid to remove the material from the semiconductor wafer.
US08691025B2	Dishwasher, in particular domestic dishwasher A dishwasher is provided that includes a washing space in which the soiled articles can be positioned for cleaning and an operating device that operates during the cleaning operation and is arranged in an opening in a bounding face of the washing space and/or of a container which can be positioned in the washing space. A spray device for spraying cleaning fluid is integrated into the washing space in the operating device.
US08691024B2	Complete sanitary system for the toilet; floor base collection and drain structure, mechanical apparatuses and plumbing method A complete sanitary system for any toilet site area which allows for the utilization of pressurized domestic running water transferred through a hose connected to a water valve diverting structure further connected to the main toilet domestic water feed line to that particular toilet's water closet. A floor structure with the aforementioned toilet mounted to its top surface side provides the structure to collect, retain and drain the spent waste water from the hose after the water has been used to cleanse the toilet site area. An alternative drainage location in the retention basin of the floor structure with coinciding plumbing piping method allows for a possible solid waste contamination scenario by an overflow toilet or otherwise to be effectively transferred directly into the main sewer pipe. The use of pressurized domestic running water in an effective manner to clean a toilet site without flooding the general bathroom floor area with water and therein providing a structure to collect and drain the spent waste water after cleansing usage provides for a totally novel and prudent sanitary cleansing approach unto the sanitation requirement of the bathroom toilet area.
US08691023B2	Methods and apparatus for cleaning deposition chamber parts using selective spray etch In one aspect, a method of cleaning an electronic device manufacturing process chamber part is provided, including a) spraying the part with an acid; b) spraying the part with DI water; and c) treating the part with potassium hydroxide. Other aspects are provided.
US08691021B2	Water-bearing household appliance A water-bearing household appliance to which fluid can be supplied during at least one filling step includes at least one drain pump for conveying fluid out of the water-bearing household appliance; and an overfill protection facility to prevent an excessive water level in the water-bearing household appliance. The overfill protection facility is configured to capture at least one operating parameter of the drain pump and after the filling step, in the presence of a malfunction of the drain pump that can be derived from the at least one operating parameter, to prevent execution of a further filling step.
US08691020B2	Washing and cleaning system for container treatment machines of the food industry The invention relates to a container treatment machine, in particular a filling, closing or rinsing unit for containers, such as bottles, cans, barrels, kegs etc., comprising a container feed, a container discharge, at least one feed line for at least one product, and a cleaning device (3) for cleaning the outer surfaces by means of a cleaning fluid (13), characterized in that the cleaning device (3) comprises a robot (4) and a track (5), wherein the track (5) runs around the rotational axis thereof in at least one angular region, wherein the robot (4) is arranged on or at said track (5) and can be driven by means of a linear drive (8).
US08691016B2	Deposition apparatus, and deposition method A deposition mask 601 is used to form a thin film 3 in a prescribed pattern on a substrate 10 by deposition. Each of a plurality of improved openings 62A of the deposition mask 601 has a protruding opening portion 64, and is formed so that the opening amount at an end in a lateral direction is larger than that in a central portion in the lateral direction. In a deposition apparatus 50, the deposition mask 601 is held in a fixed relative positional relation with a deposition source 53 by a mask unit 55. In the case of forming the thin film 3 in a stripe pattern on the substrate 10 by the deposition apparatus 50, deposition particles are sequentially deposited on the substrate 10 while relatively moving the substrate 10 along a scanning direction with a gap H being provided between the substrate 10 and the deposition mask 601.
US08691011B2	Method for metal-free synthesis of epitaxial semiconductor nanowires on si The present invention relates to epitaxial growth of nanowires on a substrate. In particular the invention relates to growth of nanowires on an Si-substrate without using Au as a catalyst. In the method according to the invention an oxide template is provided on a passivated surface of the substrate. The oxide template defines a plurality of nucleation onset positions for subsequent nanowire growth. According to one embodiment a thin organic film is used to form the oxide template.
US08691009B2	Crystal pulling apparatus and method for the production of heavy crystals A pulling apparatus and a method with which especially heavy crystals (5) can be pulled using the Czochralski method utilizing the pulling apparatus. For this purpose the neck (4) of the crystal (5) has an enlargement (10) beneath which extends the support device. This device includes latches (7), which are moved from a resting position into an operating position in which the latches (7) extend beneath the enlargement (10). Each latch (7) is supported on the base body such that it is swivellable about a pivot axis (8) and can assume two stable positions, namely the resting position and the operating position. Each of these positions is defined by a stop on the base body. When the latch rests on the one stop, its center of gravity, viewed from the neck (4), is located on the other side of the pivot axis (8). When the latch rests on the other stop, the center of gravity is located on this side of the pivot axis (8). The actuation of the latches (7) takes place with actuation means disposed stationarily in the apparatus.
US08691008B2	Systems for weighing a pulled object Pulling systems are disclosed for measuring the weight of an object coupled to a first end of a cable. The cable is routed over a pulley suspended from a load cell. The force exerted by the cable on the pulley is used to calculate the weight of the object. The second end of the cable is coupled to a drum which when rotated pulls the object by wrapping the cable around the drum. An arm is coupled to the pulley at one end and to a frame at another end. A path travelled by the cable between the pulley and the drum is substantially parallel to a longitudinal axis of the arm. Horizontal force components are transmitted by the arm to the frame and do not affect a force component measured by the load cell, thus increasing the accuracy of the calculated weight of the object.
US08691004B2	Method of ink-jet recording, pretreatment liquid, ink set, and ink-jet recording apparatus The present invention provides a method of ink-jet recording that includes the steps of pretreating by applying a pretreatment liquid onto a recording medium in advance of ink-jet recording, and recording by ejecting a pigment ink onto the recording medium by an ink-jet method. The pretreatment liquid includes the following components (i) and (ii), and water. Component (i): at least one of succinic acid and acetic acid Component (ii): alkali metal halide
US08691003B2	Composition for indicator with which used for detecting pressure points on denture An indicator is useful for detecting pressure points on a denture. The indicator is made of a composition that easily adheres to oral mucosa, has a proper viscosity in an oral cavity environment, can be properly spread between an oral mucosa surface and a denture base, and easily specifies an affected part. The composition includes a fatty acid ester having a melting point of 30 to 50° C., a water-soluble high polymer, and a metal oxide. Preferably, the fatty acid is 40 to 95% by weight of the composition, the water-soluble high polymer is 1 to 59% by weight of the composition, and the metal oxide is 0.1 to 50% by weight of the composition.
US08691002B2	Organic black pigments and their preparation A process for preparing a black colorant, preferably a black pigment, characterized in that a compound of the Formula (I) is reacted with a compound of the Formula (II) in a molar ratio of 1:2, in the presence of a catalyst which in water at 25° C. has a pK≦4.5. For the definition of R1 to R7, refer to the description; preferably all are H. Likewise claimed are new crystal polymorphs obtainable by this process, and preferably single-phase mixed crystals. Also claimed are synergistic compositions. These compositions exhibit increased light stability in plastics stabilized with basic light stabilizers when they are pigmented with colorants of the invention rather than with known black pigments such as carbon black. The specification also relates, furthermore, to the use of the black colorants of the invention for coloring paints, printing inks and plastics in the mass, and to mulch film, instrument panels, woven fabrics, garden furniture items or elements for the construction industry that are pigmented with said colorants.
US08691000B2	Wet gas scrubber A wet gas scrubber is provided for removing at least one of solid and liquid particles from water-saturated gases with a Venturi zone adjustable with respect to the flow cross-section. The wet gas scrubber includes a fixed lower Venturi plate and a vertically adjustable upper Venturi plate disposed above the fixed lower Venturi plate. The Venturi plates are substantially parallel to one another and include corresponding segments configured to engage in each other. A plurality of Venturi channels are disposed between the Venturi plates and configured to guide a mixture of a gas to be cleaned and cleaning liquid droplets injected into a stream of the gas by a nozzle. The segments of the Venturi plates engage in each other while the Venturi channels are kept free.
US08690998B2	Electric precipitator An electric precipitator includes a charge unit disposed at an upstream part and a dust collection unit disposed at a downstream part, the charge unit includes charge electrodes and a discharge wire disposed between two neighboring charge electrodes and separated from the charge electrodes, the dust collection unit includes high voltage electrodes, front ends of which are opposite to the charge unit, and low voltage electrodes, front ends of which are opposite to the charge unit and which alternate with high voltage electrodes, and the front ends of high voltage electrodes protrude toward the charge unit as compared to the front ends of low voltage electrodes, thereby guiding electrons to the discharge electrodes due to an electric field formed between the front ends of the high voltage electrodes and the discharge electrodes and thus reducing current leakage through the low voltage electrodes.
US08690996B2	Electric precipitator and electrode plate thereof An electric precipitator to collect contaminants, such as dust, using electrical attraction. The electric precipitator includes high-voltage electrode plates and low-voltage electrode plates alternately stacked to form an electrification region and a collection region in an air flow direction, wherein each of the high-voltage electrode plates includes a discharge electrode to generate discharge between the discharge electrode and an opposite electrode so that contaminants are electrified in the electrification region and a collection electrode disposed over the electrification region and the collection region to collect the electrified contaminants in the collection region.
US08690994B2	Liquid degassing membrane contactors, components, systems and related methods In at least certain embodiments, the present invention is directed to contactors, modules, components, systems, and/or methods of manufacture, and/or methods of use including degassing liquids. In at least particular possibly preferred embodiments, the contactor or module is integrally potted, has planar, disc shaped end caps, and a cylindrical housing or shell receiving and supporting a membrane structure. In at least particular possibly preferred embodiments, each of the planar disc shaped end caps has a central opening therein adapted to receive a liquid end port or nozzle, another opening therein adapted to receive a gas end port or threaded pipe, and is held in place in the housing or shell by at least one retaining element such as a retaining or locking ring. In at least particular possibly preferred embodiments, the integrally potted membrane structure is potted in place in the housing or shell by an inverted potting process involving the use of a removable plunger or plug to recess the potting.
US08690992B2	Low pressure stripping in a gas purification process and systems thereof Processes for operating an ammonia stripper at a low pressure in a gas purification system include providing a first side-draw stream from the ammonia stripper; heating the first side-draw stream with a second side-draw stream from a regenerator; providing a stripper offgas stream from the ammonia stripper to a stripper overhead condenser; and utilizing the stripper offgas stream as a heat source for a regenerating system fluidly coupled to the stripper overhead condenser. Also disclosed are systems for implementing the processes.
US08690989B2	Air quality enhancement system A system for enhancing air quality by collecting airborne particles. The system includes at least one ground plane, at least one corona point, an ionization field strength adjustment mechanism and a cleaning mechanism. The at least one ground plane is operably mounted proximate to where the airborne particles are present. The at least one ground plane includes at least one ground plane surface. The least one corona point operably is mounted to the at least one ground plane for causing an accumulation of particles to be deposited on the at least one ground plane surface. The ionization field strength adjustment mechanism enables a distance between the at least one corona point and the at least one ground plane to be adjusted. The cleaning mechanism is capable of removing the accumulation of particles from the at least one ground plane surface.
US08690983B1	Method and system for agricultural fertigation An agricultural fertigation method includes the continuous introduction of concentrated raw materials into a high-dilution irrigation-water environment whereby the stream of flowing irrigation water dampens the resultant dissolution and reaction exotherms. A system wherein raw materials are efficiently continuously fed to the irrigation system main line or a side-arm reactor efficiently implements the method.
US08690982B1	Method and system for agriculture fertigation An agricultural fertigation method includes the continuous introduction of concentrated raw materials into a high-dilution irrigation-water environment whereby the stream of flowing irrigation water dampens the resultant dissolution and reaction exotherms. A system wherein raw materials are efficiently continuously fed to the irrigation system main line or a side-arm reactor efficiently implements the method.
US08690981B2	Sintered porous plastic liquid barrier media and applications thereof This application discloses porous self-sealing media comprising a sintered mixture of an absorbent material and a thermoplastic. The self-sealing media block passage of organic solvents or organic solvents in aqueous mixtures, wherein the organic solvents are at concentrations greater than about 40%. The self-sealing media also block acidic solutions. The self-sealing media are useful in a variety of applications such as a pipette tip filter, in line filter, vent, non-mechanical check valve, safety valve, and suction canister.
US08690979B2	Dust collection device for concrete cutter A dust collection device for a concrete cutter includes a suction duct disposed on an upstream-most side; a plurality of dust collectors of a cylindrical cyclone system disposed in series downstream of the suction duct; and a plurality of dust collection chambers connected respectively to the plurality of dust collectors and storing individually dust separated in each of the dust collectors. A blower is disposed between any two of the plurality of dust collectors and performs intake and discharge of air by rotation of a built-in fan. A return flow channel communicates the suction duct with the dust collection chamber which is connected via a connection portion to a dust collector disposed on a downstream-most side from among the plurality of dust collectors, or a return flow channel communicates the suction duct with the connection portion.
US08690975B2	Gasification system with processed feedstock/char conversion and gas reformulation The invention provides a system designed for the complete conversion of carbonaceous feedstock into syngas and slag. The system comprises a primary chamber for the volatilization of feedstock generating a primary chamber gas (an offgas); a secondary chamber for the further conversion of processed feedstock to a secondary chamber gas (a syngas) and a residue; a gas-reformulating zone for processing gas generated within one or more of the chambers; and a melting chamber for vitrifying residue. The primary chamber comprises direct or indirect feedstock additive capabilities in order to adjust the carbon content of the feedstock. The system also comprises a control system for use with the gasification system to monitor and regulate the different stages of the process to ensure the efficient and complete conversion of the carbonaceous feedstock into a syngas product.
US08690974B2	Hydrogen generators A pyrolytic hydrogen generator comprising a pressure vessel containing a plurality of cardboard receptacles for the thermally decomposable hydrogen generating material and an associated ignition system. Also, a modular pellet tray assembly for use in the generator comprises a plurality of trays having pellet holders and associated igniters and held in a stack by support rods that also provide electrical connectivity to the trays. Also, a pellet tray assembly comprises a plurality of pellet holders, wherein some of more outwardly disposed pellet holders contain only outwardly facing vents and are fired first. Also, the generator has an array of hydrogen generating elements arranged side by side and separated from one another into cells by partitioning provided with directional venting that only permits laterally exiting gases to vent outwardly. Alternatively, the elements can be separated into cells by a baffle system comprising gas confining and gas venting elements, which may be heat conductive.
US08690973B2	Entrained flow reactor for gasifying solid and liquid energy sources There is described a reactor for entrained flow gasification for operation with dust-type or liquid fuels, wherein a number of gasification burners are disposed away from the reactor axis, with the center line of a gasification burner having an oblique position that is other than parallel to the reactor axis, it being possible for said oblique position to extend at different angles up to an angle of 90°. The center line does not necessarily have to intersect the reactor axis; rather the center line can pass the reactor axis at a predetermined distance. This arrangement is associated with a significant reduction in the unwanted discharge of dust-type fine slag, which is difficult to utilize, in conjunction with the possibility of reducing the reactor diameter due to its structure.
US08690965B2	Paper finishing process A process for applying a finishing paper material on a leather or woven support material is described, comprising the steps of: first buttering of glue on a surface of the support material, positioning the finishing material on said support material, ironing, perching, second buttering of glue, and a finishing step.
US08690964B2	Fabric having ultraviolet radiation protection A method for treating a fabric for protection from ultraviolet radiation is disclosed which comprises the steps of dispensing a suspension of zinc oxide particles treated with an acid polymer into a washing machine during a time in which a fabric is being washed in the washing machine and mixing the treated zinc oxide particles and the fabric for the treated zinc oxide particles to bind to the fabric. Other methods for treating a fabric for protection from ultraviolet radiation are also disclosed.
US08690963B2	Articulated hand prosthesis The invention relates to a hand prosthesis comprising a chassis and coupling elements for fastening the hand prosthesis to the stump of an arm and comprising at least one joint for the flexion and extension of the hand prosthesis in relation to the coupling elements, the chassis being kept in a neutral position against a spring force.
US08690960B2	Reinforced tissue patch A method of improving the mechanical properties of a tissue patch is provided. The method includes the steps of providing a tissue patch and placing at least one barbed suture along at least a portion of the tissue patch. The method may further include the step of placing one or more additional barbed sutures in a laterally spaced relation to the barbed suture. The barbed suture may be biodegradable or non-biodegradable.
US08690955B2	Device for unicompartmental knee arthroplasty A device for unicompartmental arthroplasty of the knee. The device permits arthroplasty of the medial and/or lateral tibial condyle, and allows for securing of the device without the use of bone cement. Such a device comprises a baseplate, the baseplate comprising a first surface configured to be secured to a surgically prepared medial (or lateral) compartment of a proximal end of a patient's tibia, and an opposing second surface configured to replicate a medial (or lateral) tibial condyle; a flange adjacent the baseplate, the flange shaped to interface with a surgically prepared anterior surface of the proximal end of the patient's tibia, the flange comprising an orifice therethrough; and at least one anchor protruding from the first surface, the at least one anchor arranged to coincide with at least one corresponding surgically prepared void in the patient's tibia.
US08690954B2	Tibial bearing component for a knee prosthesis with improved articular characteristics An orthopaedic knee prosthesis includes a tibial bearing component with articular features which operate to protect adjacent soft tissues of the natural knee, promote and/or accommodate desired articulation with an abutting femoral component, and facilitate expedient and effective implantation by a surgeon.
US08690953B2	Prosthetic implant system incorporating contrast agent The invention relates to an operation system comprising at least one implant and means for the fastening of the implant to a bone, wherein the fastening means include at least one solid spacer, which can be formed of hardened bone cement and is arranged between the implant and the bone in the implanted state, and hardenable liquid bone cement which can be introduced into hollow spaces or intermediate spaces present between the spacer and the implant and/or between the spacer and the bone and wherein the spacer, on the one hand, and the liquid bone cement, on the other hand, are provided with contrast agents chosen in dependence on an imaging observation process or inspection process, in particular an X-ray process, to be used in or after the operation such that the spacer and the liquid cement can be distinguished from the surroundings and from one another on the observation or inspection of their position, in particular in an X-ray.
US08690951B2	Base platform for an artificial joint The invention relates to a base platform (11) for an artificial joint, in particular for an artificial shoulder joint, wherein the platform can be anchored on the bone and serves as a support for an artificial joint component (15, 17) that can be provided both in the form of a shell component (15) for an anatomical configuration and also in the form of a ball component (17) for an inverse configuration, and wherein different joint components can be mounted on the platform.
US08690948B2	Interbody device and plate for spinal stabilization and instruments for positioning same Systems, methods and devices for providing stabilization between first and second vertebrae are provided. More particularly, in one form a system includes an implant configured to be positioned in a disc space between the first and second vertebrae and a freestanding plate for engagement with extradiscal surfaces of the first and second vertebrae. The system also includes an insertion instrument with an engaging portion configured to releasably engage with the implant and the plate such that the implant and plate can be positioned together relative to the first and second vertebrae. In one aspect, an angular orientation of the implant relative to the plate is adjustable when the implant and the plate are engaged by the instrument. In this or another aspect, the implant and plate are held in a contiguous relationship when engaged by the instrument. However, different forms and applications are also envisioned.
US08690941B2	Intraocular lens surgical system and method Various systems, apparatuses, and processes may be used for intraocular lens surgery. In particular implementations, a system for intraocular lens surgery may include an intraocular lens insertion cartridge and an intraocular lens interface adapted to engage an intraocular lens for advancement through the intraocular lens insertion cartridge. The system may also include a bracket that is detachably attached to the intraocular lens insertion cartridge and that facilitates securing the intraocular lens interface relative to the intraocular lens insertion cartridge.
US08690940B2	Method for the treatment of cataract A method and related apparatus to treat a cataract where the cataractous lens is pierced and the resulting opening is mechanically maintained using a lens system device such as a pinhole device, expandable tubular lens, a stent or similar small diameter device, some of which are capable of supporting a secondary intraocular lens. The resulting passageway or lumen created in the cataractous lens allows visible light to better reach the retina, thus improving vision. This lens system device that can be placed into an in situ cataract provides for a much simpler surgical technique and reduces related pre and post operative procedures and potential complications. Intraocular lenses may also be used in concert with this invention. The apparatus and technique can be applied to humans as well as animals.
US08690939B2	Method for guide-wire based advancement of a rotation assembly A method is provided including coupling a tissue-engaging element to a first portion of cardiac tissue of a heart of a patient and advancing toward the tissue-engaging element an adjustment mechanism along at least one guide member that is removably coupled to the tissue-engaging element. The adjustment mechanism engages a first portion of a first flexible longitudinal member. A second portion of the first flexible longitudinal member is coupled to a second portion of cardiac tissue. Following the coupling of the second portion of the first flexible longitudinal member to the second portion of cardiac tissue, the adjustment mechanism is slid further along the guide member and coupled to the tissue-engaging element. Using the adjustment mechanism, a length of the first flexible longitudinal member is adjusted between the first and second portions of cardiac tissue. Other applications are also described.
US08690937B2	Stent graft device A stent graft device for implanting in a body lumen, comprising a stent with non-staggered or staggered apexes, said stent comprising a plurality of stent sections, bendable connecting members forming said non-staggered or staggered apexes and connecting each of said stent sections to other stent sections to form a zigzag pattern, wherein said stent is staggerdly sutured to a graft by a plurality of suture knots, and wherein said suture knots and staggered apexes are staggered when said stent sections are crimped, and methods of use thereof.
US08690932B2	Collapsible bone screw apparatus A collapsible bone screw for healing bone fragments across a bone fracture includes an externally threaded inner screw member and an externally threaded outer screw member. The inner screw member is initially screwed into an inner bone portion. An unthreaded portion of the outer screw member is movably joined to the inner screw member. The outer screw member is screwed until it gains purchase in an outer bone portion. As impaction occurs over time, the collapsible bone screw apparatus may shorten in length as the two screw members slide, telescope or otherwise axially move toward each other to shorten the overall length, thereby preventing any portion of the screw apparatus from protruding out of the bone. A bone screw kit of multiple inner and outer screw members are provided as well as a method of surgically fastening bone fragments.
US08690929B2	Orthopedic screw for measuring a parameter of the muscularskeletal system A dual-mode closed-loop measurement system (100) for capturing a transit time, phase, or frequency of energy waves propagating through a medium (122) is disclosed. A first module comprises an inductor drive circuit (102), an inductor (104), a transducer (106), and a filter (110). A second module housed in a screw (335) comprises an inductor (114) and a transducer (116). The screw (335) is bio-compatible and allows an accurate delivery of the circuit into the muscular-skeletal system. The inductor can be attached and interconnected on a flexible substrate (331) that fits into a cavity in the screw (335). The first and second modules are operatively coupled together. The first module provides energy to power the second module. The second module emits an energy wave into the medium that propagates to the first module. The transit time of energy waves is measured and correlated to the parameter by known relationship.
US08690927B2	Bone fixture assembly An assembly for rigid bone fixation includes a plate and a screw. The screw can be rotated freely within the plate in a non-locking configuration to secure the plate against the bone. A locking mechanism is engaged to prevent the screw from moving relative the plate. In one embodiment, the plate includes a threaded portion and a non-threaded portion. The screw head rotates within the non-threaded portion to tighten the screw and pull the plate against the bone. The locking mechanism can include a moveable nut that rotates within the threaded portion of the plate to lock the screw and plate in a locking mode. The locking mechanism can include a second screw to actuate and expansion portion of screw inserted into the bone. The assembly can be used for rigid fixation of bones that experience cyclic loads, such as the sternum and mandible. Methods of rigid bone fixation are also described.
US08690925B2	Locking device for locking a rod-shaped element in a receiving part of a bone anchor and bone anchor with such a locking device A locking device includes a first locking member including a first end, a second end, a central axis, an outer surface with an external thread, a coaxial bore, and an internal thread provided along at least a portion of the bore, and a second locking member including a first end, a second end, and an outer surface with an external thread. When the second locking member is positioned in the first locking member, the second locking member is movable along the central axis by rotating the second locking member. Movement of the second locking member is limited towards the first end of the first locking member by a first stop and towards the second end of the first locking member by a second stop, where at least one of the first stop or second stop is arranged in the bore of the first locking member.
US08690924B2	Spinal screw assembly A spinal screw assembly includes a bone-anchoring member, a washer, and a seat. The bone-anchoring member includes a main shaft, a washer head, and a spherical head. The spherical head extends upward from the top end of the main shaft and the washer head extends laterally from a location of the main shaft between the main shaft's top end and bottom end. The washer is polyaxially rotatable and positionable around the washer head and is configured to be placed at a first angle relative to the main shaft. The seat is polyaxially rotatable and positionable around the spherical head independent from the washer and is configured to be placed at a second angle relative to the main shaft, wherein the second angle is independent from the first angle.
US08690923B2	Bone fixation systems and methods In some embodiments, provided is an apparatus including a first elongated member, the first elongated member including a distal end and a proximal end. The distal end of the first elongated member is coupled to a first bone portion during use. The apparatus further includes a second elongated member including a distal end and a proximal end. The distal end of the second elongated member is coupled to a second bone portion during use. The proximal end of the second elongated member comprises a surface that is shaped complementary to a surface of the proximal end of the first elongated member. The apparatus still further includes a locking mechanism coupling the proximal end of the first elongated member to the proximal end of the second elongated member. The locking mechanism is adjustable from an unlocked position to a locked position such that, when the locking mechanism is in the unlocked position, the first elongated member is angularly movable relative to the second elongated member, and when the locking mechanism is in the locked position, the complementary shaped surfaces of the first elongated member and the second elongated member are directly connected and the relative angular position of the first elongated member and the second elongated member is substantially fixed.
US08690922B2	Dynamic fixation device and method of use A dynamic fixation device is provided that allows the vertebrae to which it is attached to move in flexion within the normal physiological limits of motion, while also providing structural support that limits the amount of translation motion beyond normal physiological limits. The present invention includes a flexible portion and two ends that are adapted for connection to pedicle screws. In at least one embodiment of the present invention, the normal axis of rotation of the vertebrae is substantially duplicated by the dynamic fixation device. The flexible portion of the dynamic fixation device can include a geometric shape and/or a hinge portion.
US08690919B2	Surgical spacer with shape control A surgical spacer comprising first and second hollow support members, a flexible container, and a compressible material disposed in the container is disclosed. The first and second support members each have an exterior and an interior cavity. The exteriors of the first and second support members are affixed together and the interior cavities of the first and second support members are connected via a connecting opening. The container is disposed in the interior cavities and extends through the connecting opening. In addition, the container is substantially impermeable to the compressible material. The first and second support members are more rigid than the flexible container. A combination of the first and second support members controls the shape of the flexible container, with the compressible material disposed therein, in response to a compressive load applied to an exterior of the spacer.
US08690918B1	Spinous process fusion reduction plate for lumbar spine A spinal device in which a plate is placed on both sides of the lamina spinous process. The plates include horizontal and diagonal slots through which anchoring screws may be placed and secured. The screws may pass through the base of the spinous process and lamina structure. The plates may have cut-out portions on the ventral side to accommodate the lamina when reduction is performed. The diagonal slots preferably have an apex proximate to the dorsal side and open at the ventral side. The two plates can be mirror images of each other, and, when secured together by the screws, forms a stable construct that can sandwich the spinous process.
US08690912B2	Apparatus and methods for facilitating hemostasis within a vascular puncture Apparatus for sealing a puncture communicating with a blood vessel includes a bioabsorbable sealing member secured to one end of a filament or other retaining member. The sealing member is delivered through the puncture into the vessel, and refracted against the wall of the vessel to provide temporary hemostasis. The sealing member is rapidly absorbed after exposure within the vessel, e.g., to an aqueous or heated physiological environment (e.g., exposure to blood or body temperature), immediately or shortly after completing a medical procedure via the puncture, e.g., within the time period that the patient is ambulatory. Optionally, extravascular sealing material is delivered into the puncture proximal to the sealing member. The retaining member and/or extravascular material may be bioabsorbable, being absorbed at a slower rate than the sealing member. Alternatively, the filament is removed from the puncture after hemostasis is established.
US08690910B2	Closure device and methods for making and using them A method for closing an opening in a wall of a body lumen using a clip can include advancing a distal end of an elongate member within the body lumen, the elongate member having a distal portion that assists in presenting the wall for receiving a clip having a plurality of tissue engaging portions having tips that point generally toward a central axis of the clip. The clip can be advanced relative to the elongate member and the wall of the body lumen until the plurality of tissue engaging portions penetrate the wall of the body lumen. Once the clip penetrates the wall, the elongate member can be withdrawn from the body lumen, leaving the clip to substantially close the opening in the wall of the body lumen.
US08690906B2	Removeable embolus blood clot filter and filter delivery unit A blood clot filter is collapsible toward a longitudinal axis into a collapsed configuration for insertion into a blood vessel, and is radially expandable outwardly from the longitudinal axis to an expanded configuration for contact with the inner wall of the blood vessel at two longitudinal spaced locations. A first plurality of spaced, elongate arms, in the expanded configuration, curve outwardly away from the longitudinal axis toward the leading end of the filter to form a first filter basket and to center a hub at the trailing end of the filter within the vessel. A second plurality of spaced elongate legs angle outwardly away from the longitudinal axis toward the leading edge of the filter in the expanded configuration to form a second filter basket opening toward the leading end. The ends of these legs include hooks to bend and straighten in response to withdrawal force.
US08690903B2	Cutting balloon catheter having flexible atherotomes A cutting balloon catheter and method of making and using the same. The cutting balloon catheter may include a catheter shaft having a balloon coupled thereto. One or more cutting members or blades may be coupled to the balloon. The cutting members may configured to be more flexible.
US08690901B2	Arrangement and method for vascular anastomosis A method for implementing vascular anastomosis in the attachment of a graft vessel to a target vessel such as a coronary artery, and subsequently creating a passageway between the vessels in order to establish fluid flow communication therebetween. Further is to the provision of novel devices which are utilized in implementing the steps of attaching a graft vessel to a target vessel such as a coronary artery through vascular anastomosis, and thereafter creating a fluid flow passageway therebetween.
US08690900B2	Apparatus and method for connecting two elongate body tissues An apparatus for connecting two elongate body tissues is described. A flexible outer surface has a first outer end longitudinally spaced from a second outer end. A flexible inner surface has a first inner end longitudinally spaced from a second inner end. A first end aperture is defined by a flexible connection between the first outer end and the first inner end. The first end aperture is configured to accept a first elongate body tissue. A second end aperture is defined by a flexible connection between the second outer end and the second inner end. The second end aperture is configured to accept a second elongate body tissue. The outer and inner surfaces are configured for relative eversion operative to longitudinally shift an instantaneous midpoint of the apparatus with respect to a reference location on the inner surface. A method of using the apparatus is also provided.
US08690894B2	Automated system for harvesting or implanting follicular units An automated system for harvesting or implanting follicular units, including a moveable arm; a harvesting and/or implantation tool mounted on the moveable arm; one or more cameras mounted on the moveable arm; a processor configured to receive and process images acquired by the one or more cameras; and a controller operatively associated with the processor and configured to position the moveable arm based, at least in part, on processed images acquired by the one or more cameras, wherein the moveable arm is positionable such that the tool may be positioned at a desired orientation relative to an adjacent body surface.
US08690891B2	Steerable surgical snare Apparatus, assemblies, and methods for capturing objects within a body are disclosed. A surgical snare device includes a steerable deflection portion with a steerable distal tip. An interface is linked to the steerable deflection portion to selectively manipulate the distal tip. A snare loop disposed at the distal tip can have a length that remains substantially constant as the distal tip is deflected and the snare loop moves in concert with the distal tip. The distal tip may deflect up to at least one-hundred eighty degrees, while the snare loop moves a corresponding amount. A method includes extending a snare through a body lumen and to a location near an object. The snare may have a loop that changes positions while maintaining the same length. The loop may be placed around an object and then used to retrieve the object from the body lumen.
US08690888B2	Modular active spine tool for measuring vertebral load and position of load A spine measurement system includes a plurality of sensored heads, a spinal instrument, and a remote system. The spinal instrument comprises a handle, a shaft, sensored heads, and a module. The sensored heads includes one or more sensors that couple to module and each has a different height. The module includes an electronic assembly for receiving, processing, and sending quantitative data from sensors in sensored heads. The module can be coupled to and removed from handle. Similarly, sensored heads can be coupled to and removed from shaft. A sensored head can be inserted between vertebra and report vertebral conditions such as force, pressure, orientation and edge loading. A GUI of remote system can display a workflow and report load and position of load during the workflow.
US08690884B2	Multistate-curvature device and method for delivering a curable material into bone A curable material delivery cannula device and method are disclosed. The device includes a cannula and a hub. The cannula includes an open proximal end, a deflectable segment forming a plurality of pre-set curves, each of which corresponds to a pre-determined temperature of the cannula, a lumen, and side orifice(s) adjacent, and proximally spaced from, the distal end and fluidly connected to the lumen. When distally extended from the guide cannula, and upon being heated to a predetermined temperature (before, during, or after extension), the deflectable segment assumes a curved shape, which may be used to create a void in the bone for receiving curable material. The distal cannula end includes a blunt tip for non-traumatic interface with bodily material. During use, curable material, such as bone cement, is delivered from the side orifice(s) in a radial direction relative to the lumen.
US08690879B2	Retraction tube for use with capless pedicle screw A retractor system and method for locating and placing a polyaxial screw while substantially simultaneously retracting tissue is shown and described. The retractor has a channel that facilitates introducing a rod into the polyaxial screw. Various embodiments are shown, including one which utilized a reducer for moving the rod in the retractor.
US08690877B2	Femoral ring loader An instrument for inserting an implant between vertebral bodies, including a holder adapted to hold the implant during insertion of the implant between the vertebral bodies, a retractor adapted to retract the holder away from the implant after the insertion, and a guard adapted to prevent the implant from being removed from between the vertebral bodies during the retraction.
US08690876B2	Cutting burr shank configuration A cutting burr that includes a pair of axially spaced diamond-shaped portions designed to be keyed into a spindle of a locking mechanism of a high speed surgical drilling instrument and adapted to fit into a single pawl thereof to lock said cutting burr in place so as to prevent axial movement thereof and provide concentric rotation of said cutting burr without any wobbling. The orientation of both portions may be identical with respect to a center plan and diamond shape in the portion at the proximal end of the shank of the cutting tool may be larger than the intermediately located diamond shape of the other portion. The apexes of the facets of the six-sided diamond shape may be disposed below the surface of the shank of the cutting burr.
US08690875B2	Method and apparatus for preparing bone for a prosthetic device A system (10) for preparing a long bone for a prosthetic, the long bone having a long axis comprises a distal instrument (12) and a proximal instrument (14). The distal instrument (12) is configured to remove bone from a distal portion of bone. The distal instrument (12) has a bone removing portion (16) configured to remove bone along the long axis of the long bone and a shaft (18) extending from the bone removing portion (16) along the long axis of the long bone. The proximal instrument (14) is configured to overlie the shaft (18) of the distal element (12) within the long bone. The distal shaft (18) guides the proximal instrument (14) to prepare the proximal portion of the long bone after the distal instrument (12) has prepared the distal portion of the long bone.
US08690874B2	Composition and process for bone growth and repair A composition for the induction of bone growth is disclosed. The composition includes a substrate, bone growth protein, and sources of calcium and phosphate. The composition is acidic which promotes high activity of the bone growth protein. The calcium and phosphate sources can be provided as an acidic calcium phosphate salt. Also disclosed are methods of the making the composition and methods of using it.
US08690870B2	Irrigated ablation catheter system with pulsatile flow to prevent thrombus The invention relates to an ablation catheter which controls the temperature and reduces the coagulation of biological fluids on an electrode of a catheter, prevents the impedance rise of tissue in contact with the electrode, and maximizes the potential energy transfer to the tissue, thereby allowing an increase in the lesion size produced by the ablation. The electrode includes passages positioned to allow saline flow out of an inner cavity of the electrode. This fluid flow is pulsatile to increase turbulence, reducing areas of stagnant flow, and produces a desired cooling effect.
US08690869B2	Electrosurgical devices with directional radiation pattern A device for directing energy to a target volume of tissue includes an antenna assembly and an elongated body member. The elongated body member includes a proximal end portion and a distal end portion, wherein the proximal and distal end portions define a longitudinal axis. The elongated body member has a chamber defined therein that extends along the longitudinal axis, and a body wall surrounding the chamber. An antenna assembly is disposed in the chamber. The elongated body member also includes an opening in the body wall to allow energy radiated from the antenna assembly to transfer into the target volume of tissue.
US08690866B2	Ablation devices utilizing exothermic chemical reactions, system including same, and methods of ablating tissue using same An ablation device includes a handle assembly including a distal end and a probe extending distally from the distal end of the handle assembly. The probe includes a heat-transfer portion and at least one fluid-flow path in fluid communication with the heat-transfer portion. The handle assembly includes at least one fluid reservoir in fluid communication with the at least one fluid-flow path and at least one apparatus configured to cause fluid flow between the at least one fluid reservoir and the heat-transfer portion. The probe is configured to apply thermal energy released by an exothermic chemical reaction that occurs when fluid from the at least one fluid reservoir is caused to flow to the heat-transfer portion.
US08690865B2	Methods and devices for thermal treatment The present invention comprises methods and devices for thermal treatment of a barrier to increase the permeability of the barrier. One form of increasing the permeability of the barrier comprises forming micropores which may be used for administration of active agents across the barrier, or may be used for sampling or collecting fluids, or may be used for detecting, measuring or determining analytes, or may be used for monitoring of physiological or other conditions. Devices of the present invention may comprise microheaters that are activated by inductive or ohmic heating power supply components.
US08690857B2	Alleviate back pain with lactic acid inhibitors The intervertebral disc is avascular. Nutrients and waste are diffused through adjacent vertebral bodies into the disc. As we age, calcified layers form between the disc and vertebral bodies, blocking diffusion of nutrients, oxygen and pH buffer in blood. Under anaerobic conditions, lactic acid is produced, irritating nerve endings and causing nonspecific pain. In addition, the disc begins to starve and flatten. The weight shifts abnormally from disc to the facet joints causing strain and back pain.Lactic acid inhibitor inhibits production of lactic acid from pyruvate within the disc to reduce or alleviate back pain.
US08690854B2	Medicament admixing system A system for mixing or reconstituting a drug contained in a first container with a diluent or fluid contained in a second container. The second container has a port docking assembly for engaging the first container. The first container is rotatable and axially slidable within the port docking assembly. The port docking assembly has an actuator to urge a stopper fluidly sealing the first container into the interior of the first container. The port docking assembly further includes a movable plug constructed to fluidly seal the second container in a first, docked position and to provide access to the interior of the second container in a second, activated position, whereby fluid communication between the first and second containers is provided when the first and second containers are in the second, activated position.
US08690853B2	Methods and apparatus for buffering parenteral solutions A system for transferring solutions from a first cartridge into a second cartridge comprises a cartridge holder, a plunger driver, and a cartridge connector. The cartridge connector carries a transfer needle and an exhaust needle. The cartridge holder positions the first cartridge against the cartridge connector so that the transfer needle penetrates the first cartridge septum. The second cartridge is removably inserted into another end of the cartridge connector so that both the transfer needle and the exhaust needle penetrate the second cartridge septum. The plunger driver is disposed to advance a plunger on the first cartridge to transfer solution from the first cartridge into the second cartridge thus displacing solution from the second cartridge through the exhaust needle. The cartridge connector includes a sealed interior waste chamber for receiving the solution from the second cartridge.
US08690851B2	Disposable absorbent article having tailored leg edge A disposable absorbent article comprises a first crotch elastic member adjacent a first crotch edge and a second crotch elastic member adjacent a second crotch edge, each crotch elastic member extending generally in a longitudinal direction, each crotch elastic member having a front terminal point and a rear terminal point. In one embodiment, at least one of the terminal points of the first crotch elastic member is positioned transversely inward from a remaining portion of the first crotch elastic member, and at least one of the terminal points of the second crotch elastic member is positioned transversely inward from a remaining portion of the second crotch elastic member. In another embodiment, front end portions of the first and second crotch elastic members or rear end portions of the first and second crotch elastic members converge transversely inward toward each other.
US08690847B2	Sanitary protection device A sanitary protection device intended to be placed in the user's vagina (7). Distinguishing features of the sanitary protection device are that it includes a shell-like basic element (1), that the basic element (1) has in its height direction (H) a shape which narrows both upwards and downwards from an intermediate portion, and that the basic element (1) is provided with apertures (5) along part of its external surface.
US08690846B2	Combination of two disposable waste containment articles worn simultaneously A disposable waste containment article is disclosed along with a combination of using two articles simultaneously. The article includes a bodyside layer having a first surface and an outer perimeter, and a garment facing layer having an outer perimeter approximately coincident with the outer perimeter of the bodyside layer. An absorbent layer is positioned between the bodyside layer and the garment facing layer. A seal secures the bodyside layer to the garment facing layer. The seal is located inward of the outer perimeters. An ingress is formed in the bodyside layer and is aligned with one of the waste orifices present in a human body such that waste from the human body can pass through the ingress and be collected in the waste containment article. The waste containment article also includes a body adhesive for securing the first surface to the wearer's body.
US08690845B2	System and method for interfacing with a reduced pressure dressing Systems, devices, and methods for treating a tissue site on a patient with reduced pressure are presented. In one instance, a reduced-pressure interface includes a conduit housing having a cavity divided by a dividing wall into a reduced-pressure-application region and a pressure-detection region. The reduced-pressure interface further includes a reduced-pressure port disposed within the reduced-pressure-application region, a pressure-detection port disposed within the pressure-detection region, and a base connected to the conduit housing, the base having a manifold-contacting surface. The dividing wall includes a surface substantially coplanar with the manifold-contacting surface.
US08690841B2	Wound care system An improved wound care system is set forth. The system includes a wound care device having a first end and a second end. A fastener, adapted to extend to a desired length to selectively attach the device at an anchor, wherein the anchor is provided on a second end of the device is also provided. The fastener is sufficiently sized and formed of a suitable material to prevent the device from moving when secured to the anchor. In an embodiment, medicine is provided in a desired treatment area of the device. The medicine can be inserted via a medicinal delivery device by inserting the medicinal delivery device up to a stop on the medicinal delivery device into the wound care device.
US08690840B2	Time-selective bioresorbable or collapsible drug delivery systems and methods Implantable medical devices and treatment methods are provided, particularly for use in the bladder. The device is configured for retention in the bladder for at least a portion of the drug delivery period and includes at least one biodegradable component such that following a biodegradation at a selected time, the retention function is lost and the device or portions thereof are resorbed and/or excreted. The method may include deploying into the bladder of a patient a device having a device structure housing a drug formulation comprising at a drug; releasing drug from the device structure into the bladder; and then, changing the composition of urine in the bladder, e.g., by altering the pH, to trigger degradation of at least part of the device structure to enable the device structure or parts thereof to be excreted from the bladder.
US08690838B2	Transdermal administration device The transdermal administration device of the present invention includes: a needle support with a plurality of microneedles formed at a tip portion thereof; a holder with the needle support placed therein, allowing the needle support to protrude itself therefrom and retract therein; and a cap for covering the microneedles, and further includes: a spring member placed between the needle support and the holder, for biasing the needle support in a protruding direction; an engaging portion at a base of the needle support; and an engaged portion capable of engaging the engaging portion, formed in the holder, where the engaging portion of the needle support can be locked with the engaged portion of the holder when the needle support is retracted in the holder.
US08690837B2	Mixing device for a two-chamber ampoule A device for administering a product (e.g. a medicinal or therapeutic substance), the device including a receptacle for the product or constituents of the product and a casing, wherein the receptacle and casing are engaged, and an outer sleeve, wherein the casing can be moved relative to the receptacle into the outer sleeve.
US08690835B1	Garment for accommodating intravenous catheters and gastronomy tube A garment for use with a patient requiring treatment with a central venous catheter and/or gastrostomy tube. Access openings are provided through which the catheter or tube may be reached from the outside of the garment and, in the case of the catheter, coiled on the outside of the garment. Flaps are attached to the garment for covering the access openings and securing the catheter or tube under the flaps. When the access openings are connected with an open ended slot to a central longitudinal opening in the front of the garment, the catheter or tube may be passed into the access opening and the garment put on and taken off without disturbing the medical appliance to which the catheter or tube is attached.
US08690833B2	Intravenous catheter and insertion device with reduced blood spatter An venous access catheter is combined with a needle, guidewire, and actuator where the needle is disposed coaxially over the guidewire and the catheter is disposed coaxially over the needle. A hub at a proximal end of the access catheter includes a wiping element to clean blood from the needle and guidewire as they are removed and a side port to allow connection of fluids after the access catheter is placed.
US08690831B2	Gas jet fluid removal in a trocar Devices and methods are provided for removing fluid from a surgical access device and/or from surgical instruments passed therethrough, and for preventing such fluid from accumulating. For example, in one embodiment, an exemplary device can include a body defining a working channel that is configured and sized to allow for passage of a surgical instrument therethrough. A number of seals can be disposed in the working channel so as to contact the inserted surgical instrument. One or more outlets can be oriented to direct gas, such as air or an insufflation gas, into the working channel so as to remove fluid on the seals, or other parts of the surgical access device, as well as the surgical instruments themselves. In some embodiments, constant flows of gases can be arranged to act as shields to help prevent fluid from accumulating on the surgical access device and/or surgical instruments.
US08690830B2	In-plane electromagnetic MEMS pump A micromechanical pumping system is formed on a substrate surface. The pumping system uses a pumping element which pumps a fluid through valves which move in a plane substantially parallel to the substrate surface. An electromagnetic actuating mechanism may also be fabricated on the surface of the substrate. Magnetic flux produced by a coil around a permeable core may be coupled to a permeable member affixed to a pumping element. The permeable member and pumping element may be configured to move in a plane parallel to the substrate. The electromagnetic actuating mechanism gives the pumping system a large throw and substantial force, such that the fluid pumped by the pumping system may be pumped through a transdermal cannula to deliver a therapeutic substance to the tissue underlying the skin of a patient.
US08690827B2	Devices, systems, and methods for medicament delivery Certain exemplary embodiments comprise can comprise an auto-injector, which can comprise: a vial configured to store and/or contain an injectable medicament, the vial defining a vial longitudinal axis, and a housing comprising the vial. In various embodiments, the injectable medicament can be a medicine, medication, drug, pharmaceutical, prescriptive, agent, antidote, anti-venom, hormone, stimulant, vasodilator, anesthetic, and/or nutritional supplement that is substantially ready for injection.
US08690826B2	Heating/ cooling system for indwelling heat exchange catheter A cooling system for an indwelling heat exchange catheter includes a heat exchange bath that is configured to receive a conduit that carries saline to and from the catheter. A heating/cooling fluid is in the bath and exchanges heat with the saline. The heating/cooling fluid flows through a heat exchanger that includes a refrigerant and two variable speed DC compressor for removing heat from the refrigerant. A gear pump circulates the working fluid to and from the catheter and is removably engaged with a pump support platform.
US08690825B2	Safety syringe The present invention relates to a safety syringe. The safety syringe comprises a barrel having a plurality of elastic support units in the inner side, a plunger having a rubber ring and a first coupling portion at the front-end, and an injection head unit comprising a first needle seat, a second needle seat, and a needle, wherein the second needle seat comprises a second coupling portion. When the injection head unit is mounted on the front-end opening, the second needle seat is propped by the plurality of elastic support units preventing the needle seat from being crushed during injection. After injecting, the first coupling portion is pushed to couple with the second coupling portion, and then the needle can be pulled into the barrel for safety.
US08690824B2	Medical devices and related methods This disclosure relates to medical devices and related methods. In some embodiments, the methods include applying a material to the balloon and then removing the material from one or more regions of the balloon.
US08690822B2	Drug delivery medical devices Medical devices for delivering a bioactive agent and methods of use thereof are provided. The device includes a balloon having micro-needles for delivery of the bioactive agent.
US08690819B2	Ultrasound catheter for disrupting blood vessel obstructions Ultrasound catheter devices and methods provide enhanced disruption of blood vessel obstructions. Generally, an ultrasound catheter includes an elongate flexible catheter body with one or more lumens. An ultrasound transmission member or wire extends longitudinally through the catheter body lumen and, in many embodiments, a guide wire tube also extends through the same lumen. A distal head is fixed to or otherwise mechanically coupled with the distal end of the ultrasound transmission member or wire and is positioned adjacent the distal end of the catheter body. Although the distal end of the catheter body overlaps the distal head, the distal head is not directly affixed to the distal end of the catheter body. Thus, the distal tip may move freely, relative to the distal end of the catheter body when ultrasonic energy is applied through the ultrasound transmission member. Such a freely floating distal head enhances the efficiency of an ultrasound catheter, enabling the catheter to ablate calcific occlusions and increasing the useful life of the ultrasound transmission member and catheter.
US08690817B2	Systems and method for bypassing an anastomosis site A system for bypassing an anastomosis site in a hollow organ is provided. The system includes a sleeve configured for spanning the anastomosis site at an internal surface of the hollow organ and a band configured for attachment to an external surface of the hollow organ and limiting migration of the sleeve beyond the anastomosis site.
US08690813B2	Radiation treatment garment—I A radiation treatment garment includes, in some embodiments, a window having a visually-transparent material for viewing alignment tattoos on a wearer. In some other embodiments, the radiation treatment garment includes a support pouch for receiving and supporting a male wearer's external genitalia, wherein the support pouch is configured to support the external genitalia in a position that is anterior and superior to the natural gravity-induced position. In some further embodiments, the radiation treatment garment includes both the window and the support pouch.
US08690812B2	Post operative knee brace with uniform symmetrical lateral adjustment A knee brace incorporates an upper attachment assembly received anteriorly on a thigh of and a lower attachment assembly to be received on a lower leg of a patent. Medial and lateral longitudinal supports are interconnected at medial and lateral hinges. An outer lateral arcuate support plate is attached to a first end of the lateral longitudinal support and an outer medial arcuate support plate is attached to a first end of the medial longitudinal support. Symmetrical lateral adjustment is accomplished with an anterior arcuate support plate and a lateral adjustment ratchet mounted to the anterior support plate. A lateral adjustment strap extends from the lateral arcuate support plate through the lateral adjustment ratchet. A lateral adjustment strap extends from the medial arcuate support plate through the lateral adjustment ratchet and rotation of the lateral adjustment ratchet symmetrically expands or retracts the lateral adjustment straps.
US08690799B2	Acoustic respiratory monitoring sensor having multiple sensing elements According to certain described aspects, multiple acoustic sensing elements are employed in a variety of beneficial ways to provide improved physiological monitoring, among other advantages. In various embodiments, sensing elements can be advantageously employed in a single sensor package, in multiple sensor packages, and at a variety of other strategic locations in the monitoring environment. According to other aspects, to compensate for skin elasticity and attachment variability, an acoustic sensor support is provided that includes one or more pressure equalization pathways. The pathways can provide an air-flow channel from the cavity defined by the sensing elements and frame to the ambient air pressure.
US08690796B2	Method and apparatus for penetrating tissue A tissue penetrating system has a housing member. A plurality of penetrating members are positioned in the housing member. A tissue stabilizing member is coupled to the housing. A penetrating member sensor is coupled to the plurality of penetrating members. The penetrating member sensor is configured to provide information relative to a depth of penetration of a penetrating member through a skin surface.
US08690793B2	Biopsy device having rotational cutting A biopsy device includes a probe assembly and a driver unit. The probe assembly includes a first cannula having a first aperture extending to a lumen proximal to a first distal end of the first cannula. A second cannula has a second aperture extending to a lumen proximal to the second distal end of the second cannula. The second cannula is disposed co-axially with the first cannula. A least one of the first aperture and the second aperture has a cutting edge. The driver unit is configured for releasably mounting the probe assembly. The driver unit is operatively configured to simultaneously rotate the first cannula and the second cannula at different rotational velocities so that the first aperture and the second aperture periodically come into alignment to form a virtual tissue sample aperture.
US08690792B2	Direct assay of cholesterol in skin removed by tape stripping Skin cholesterol is measured by applying an adhesive tape onto a selected area of the skin to adhere the tape to the selected skin area and stripping the tape off the selected skin area to obtain a sample representative of the outer stratum corneum layer of the skin, the sample adhering to the tape so as to have exposed skin constituents. The sample is assayed using a detector reagent that specifically binds to cholesterol and in addition has an indicator component that allows quantitation of the amount of cholesterol present in the exposed skin constituents.
US08690789B2	Categorizing automatically generated physiological data based on industry guidelines Methods and systems for mapping a physiological signal into clinical guideline parameters are disclosed. A physiological signal having a characteristic that may represent an anomaly is received and mapped to a clinical guideline condition space. Probabilities are determined that the mapped signal with which the anomaly may be associated represents a first clinical guideline condition corresponding to a referral indication or a second clinical guideline condition corresponding to an absence of the referral indication. The determined probability is presented and a referral decision is made responsive to the determined probability that the anomaly is associated with the first clinical guideline condition.
US08690784B2	Monitoring system for cardiac surgical operations with cardiopulmonary bypass A monitoring system for cardiac operations with cardiopulmonary bypass comprising: a processor operatively connected to a heart-lung machine; a pump flow detecting device connected to a pump of the heart-lung machine to continuously measure the pump flow value and send it to the processor; a hematocrit reading device inserted inside the arterial or venous line of the heart-lung machine to continuously measure the blood hematocrit value and to send it to the processor; a data input device to allow the operator to manually input data regarding the arterial oxygen saturation and the arterial oxygen tension; computing means integrated in the processor to compute the oxygen delivery value on the basis of the measured pump flow, the measured hematocrit value, the preset value of arterial oxygen saturation, and the preset value of arterial oxygen tension; and a display connected to the processor to display in real-time the computed oxygen delivery value.
US08690783B2	Ultrasonic transducer assembly An ultrasound transducer assembly includes an acoustic focusing lens and a therapy transducer mounted to a holder member so that the lens is movable relative to the transducer. The lens and the transducer are mounted to the holder member so that the lens is spaced a predetermined distance from the transducer element. A liquid layer having a thickness of the predetermined distance is provided between the lens and the transducer element. A solid backing member is disposed on a side of the transducer element opposite the lens. The backing member is spaced by an additional liquid layer of a predetermined thickness from the transducer element. The focusing depth of the lens-transducer assembly is controllable by transducer operating frequency.
US08690779B2	Noninvasive aesthetic treatment for tightening tissue Systems and methods for noninvasive tissue tightening are disclosed. Thermal treatment of tissues such as superficial muscular aponeurosis system (SMAS) tissue, muscle, adipose tissue, dermal tissue, and combinations thereof are described. In one aspect, a system is configured for treating tissue through delivery of ultrasound energy at a depth, distribution, temperature, and energy level to achieve a desired cosmetic effect.
US08690776B2	Systems, methods, apparatuses, and computer-readable media for image guided surgery Presented herein are methods, systems, devices, and computer-readable media for image guided surgery. The systems herein allow a physician to use multiple instruments for a surgery and simultaneously provide image-guidance data for those instruments. Various embodiments disclosed herein provide information to physicians about procedures they are performing, the devices (such as ablation needles, ultrasound wands or probes, scalpels, cauterizers, etc.) they are using during the procedure, the relative emplacements or poses of these devices, prediction information for those devices, and other information. Some embodiments provide useful information about 3D data sets. Additionally, some embodiments provide for quickly calibratable surgical instruments or attachments for surgical instruments.
US08690775B2	Transcutaneous analyte sensor The present invention relates generally to systems and methods for measuring an analyte in a host. More particularly, the present invention relates to systems and methods for transcutaneous measurement of glucose in a host.
US08690774B2	Analyzer for measuring blood gas parameters The invention relates to a method and device for measuring blood gas parameters, preferably pH, pCO2, and pO2, in a blood sample, where the blood sample of a patient is fed into at least one measuring cell of an analyzer. In order to obtain accurate values for the blood gas parameters even in cases where the temperature of the patient deviates from normal temperature, the temperature of the patient or blood sample is measured upon sample withdrawal, and the measured temperature is transmitted to the analyzer or is recorded by the analyzer, and the temperature of the measuring cell of the analyzer is adjusted to the measured temperature by cooling or heating.
US08690762B2	Transparent endoscope head defining a focal length A catheter configured for imaging objects substantially in focus is described herein. An imaging device is disposed on the distal end of the catheter. The imaging device has an effective focal plane that is located in front of the imaging device. The catheter also includes a transparent focal instrument that has an outer periphery that is positioned at the effective focal plane of the imaging device, to enable objects in contact with the outer periphery of the transparent focal instrument to be imaged substantially in focus.
US08690751B2	Sleep and environment control method and system A sleep system is provided that aids in achieving a sleep goal by controlling the environment near a person. The sleep system executes instructions on a processor that interfaces with the person and various environmental controls. As the instructions are executed, the sleep system receives a sleep goal for the person that includes varying the nearby environment. The processor may further execute instructions to create settings that vary at least one environmental condition of the environment over time as it relates to one or more cycles of a sleep architecture for the person. Varying at least one environmental condition near the person experiencing one or more cycles of the sleep architecture influences the quality of the person's sleep. The sleep system may further adjust at least one environmental condition in the vicinity of the person tailored to the sleep architecture for the person.
US08690749B1	Wireless compressible heart pump An apparatus with a compressible construction having a wireless power source structured around a cylindrical-shaped support that suspends a motor within the vascular system while also supporting an impeller pump that can be made to be collapsible. The whole system allows for a minimally invasive pump implantation and augmentation of flow.
US08690747B2	Eyelid plaque An eyelid plaque and a method of using the plaque to treat eye cancers. The eyelid plaque is placed on the eyelid such that it defines an enclosure within which the radiation source resides. The enclosure defines a radiation shield that reduces radiation entering other organs and structures proximate the cancer being treated.
US08690737B2	Exercise machine A dual mode exercise machine which can work in a stepping mode, or in an elliptical mode, and which has an interlock mechanism which ensures that the machine cannot be placed in a condition in which neither mode is engaged.
US08690735B2	Systems for interaction with exercise device An exercise device is configured to enable a user to interact with a trainer in real-time communication. The exercise device includes an exercise mechanism having a movable element for movement in performance of exercise by a user. Communicating with the exercise mechanism is an interface adapted for gathering a first real-time signal from the user. The interface communicates with a communication system for receiving a packetized second real-time signal including a synchronized control signal from the trainer. The exercise device includes an output device configured to reproduce the second real-time signal. The control signals carried by the second signal are used to control the operating parameters of the exercise mechanism in real-time.
US08690733B2	Vehicle control system and control method thereof A time required until the friction element is completely engaged is delayed when a switch from a non-driving position to a driving position is detected or when the engine automatic stop condition no longer holds until the differential rotation of the friction element disappears after the engine automatic stop condition holds as compared with the case where the switch from the non-driving position to the driving position is detected or the engine automatic stop condition no longer holds after the differential rotation of the friction element disappears.
US08690716B2	Belt-driven conical-pulley transmission and motor vehicle with such a transmission Conical disk pairs of a belt-driven conical-pulley transmission include an axially fixed disk and an axially movable disk that are situated on respective shafts on the input side and the output side and are connectable by an endless torque-transmitting component for transmitting torque. At least one of the shafts has at least one axial bore from which at least one connecting bore extends to the surface of the shaft. The outlet of the connecting bore is in a region that is covered by the movable disk independent of the latter's axial position. An annular chamber formed between the shaft outer surface and a radially inner surface of the axially movable disk can be subjected to hydraulic pressure through the connecting bore. A discharge groove is provided for bleeding air bubbles from the annular chamber.
US08690711B2	Data display on golf ball outer surface A plurality of layers and elements are incorporated into a golf ball to display values for various swing characteristics on a display layer of a ball. A calculator is incorporated to calculate a value of at least one swing characteristic. A weighted light source is incorporated to display the value on a display layer. The display layer is a substantially opaque layer.
US08690710B2	Club head sets with varying characteristics and related methods Embodiments of golf clubs head sets with varying characteristics are disclosed herein. Other examples and related methods are also generally described herein.
US08690709B2	Golf club having two-part head A golf club with a golf club head formed of two distinct parts is presented. The club head includes a lower, ball striking member configured to contact a golf ball. The club head further includes an upper member, connected to the ball striking member at a top surface of the ball striking member. The ball striking member may be formed of a more dense material than the upper portion, thereby lowering the center of gravity of the club to provide improved performance characteristics.
US08690705B2	Golf clubs and golf club heads having adjustable characteristics A golf club head which may include a golf club head body, a ball striking face and a piezoelectric member in the golf club head, wherein the piezoelectric member is configured to be selectively adjusted by an input provided through a controller operably connected to the piezoelectric member. Further, the piezoelectric member may be capable of having a first configuration to provide the golf club head body with a first attribute and may also be capable of having a second configuration to provide the body with a second attribute in response to the input provided by the controller. Further, the second attribute may be different from the first attribute.
US08690704B2	Golf club assembly and golf club with aerodynamic features A golf club head includes a body member having a length dimension, a height dimension, a breadth dimension, a center-of-gravity and a face-squared centerline. The body member includes a channel having an inlet, an outlet and a throughbore extending through the body member from the inlet to the outlet. The inlet is located to a heel-side of the centerline of the body member and the outlet is located to a toe-side of the centerline of the body member. A golf club including the golf club head is also provided.
US08690702B2	Golf club A golf club has a reverse flex of 110 to 160 mm. The face portion includes a central thick part, a toe-crown-side thin part on a crown-side and on a toe-side of the central thick part, and a heel-sole-side thin part on a sole-side and on a heel-side of the central thick part. In the front view of the head, a first straight line passing an area centroid of the toe-crown-side thin part and an area centroid of a back surface of the face portion has an angle θA of 10 to 30 degrees, and a second straight line passing an area centroid of the heel-sole-side thin part and the area centroid of the back surface of the face portion has an angle θB of 36 to 40 degrees, each with respect to the horizontal plane.
US08690700B2	Club head with club head alignment aid and related method A wood-type club head can include a front end having a front face, a toe end, a heel end opposite the toe end, a rear end opposite the front end, a crown surface having a front crown end and a rear crown end, and an alignment aid at the crown surface. The front crown end can be closer to the front end than to the rear end, and the rear crown end can be closer to the rear end than to the front end. The alignment aid can include three alignment aid stripes. The three alignment aid stripes can include a toe alignment aid stripe, a heel alignment aid stripe, and a center alignment aid stripe. Other embodiments are also disclosed.
US08690694B2	Free fall amusement ride An amusement ride apparatus comprising: a free fall tower having a proximal end hingedly attached to a base platform and a distal end; a lifting assembly connected to the base platform and the free fall tower so that the free fall tower can transition between a loading position and a free fall position; a trolley slideably attached to the free fall tower; a trolley securing assembly attached to the trolley and releasably attached to the distal end of the tower for securing the trolley to the distal end prior to the free fall tower transitioning from the loading position to the free fall position so that the trolley is held at the distal end when the tower is in the free fall position; a braking assembly carried by the base platform for slowing the downward movement of the trolley when the trolley securing member is released; and, a passenger carriage pivotably carried by the trolley allowing the passenger carriage to pivot to maintain a generally upright orientation as the free fall tower transitions from the loading position to the free fall position.
US08690689B1	Driveshaft coupling A connection apparatus includes a first flange member having a threaded portion; a second flange member having a threaded portion; a central annular connecting flange positioned in between the first and second flanges; a pair of cross trunnion assemblies being next to and on opposing sides of the annular connecting flange; a pair of threaded collars connecting each trunnion assembly to the connecting flange and a flange; a plurality of key and slot connections that provide an interlocking interface between each flange and each trunnion assembly; and bolted connections the secure each trunnion assembly to the central annular connecting flange.

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