Document Document Title
US08680556B2 Composite high reflectivity layer
A high efficiency light emitting diode with a composite high reflectivity layer integral to said LED or package to improve emission efficiency. One embodiment of a light emitting diode (LED) chip comprises a LED and a composite high reflectivity layer integral to the LED to reflect light emitted from the active region. One embodiment of a LED package comprises a LED mounted on a substrate with an encapsulant over said LED and a composite high reflectivity layer arranged to reflect emitted light. The composite layer comprises a plurality of layers such that at least one of said plurality of layers has an index of refraction lower than the encapsulant and a reflective layer on a side of said plurality of layers opposite the LED. In some embodiments, conductive vias are included through the composite layer to allow an electrical signal to pass through the layer to the LED.
US08680551B1 High power ultraviolet light sources and method of fabricating the same
A vertically conducting LED comprising, in a layered arrangement: a highly thermally conductive submount wherein the highly conductive submount has a thermal conductivity of at least 100 W/m0K; a p-type layer comprising Al1-x-yInyGax N wherein 0≦x≦1 and 0≦y≦1; a quantum well layer comprising Al1-x-yInyGaxN wherein 0≦x≦1 and 0≦y≦1; an n-type layer comprising Al1-x-yInyGaxN wherein 0≦x≦1 and 0≦y≦1; and an n-type contact layer wherein the LED has a peak emission at 200-365 nm.
US08680547B2 Light emitting device comprising a multiphase ceramic material
The invention relates to a light emitting device comprising a light source, especially a LED, and a luminescent material, which is a ceramic multiphase material essentially of the composition M2−zCezSi5−x−y−(z−z1)Ay+(z−z1)N8−4x−y+z1O4x+y−z1. This material has been found to have a composition of at least two phases, which leads to a better producibility as well as photostability and conversion efficiency.
US08680545B2 Light emitting device and method for fabricating the same
Embodiments of a light emitting device and a method for fabricating the same are provided. The light emitting device comprises a cavity and one or more light emitting elements. The cavity is formed to a depth of 450 μm or less, and the light emitting elements are installed in the cavity. A fabricating method includes forming a package body having a cavity with a depth of 250 μm to 450 μm and at least one lead frame disposed at the bottom surface of the cavity, mounting at least one light emitting element on the lead frame, and molding a molding member in the cavity.
US08680540B2 Optical semiconductor apparatus having a bidirectional communication system employing a single-core optical fiber
The optical semiconductor apparatus includes, on an n-GaAs substrate, a surface-emitting semiconductor laser device and a photodiode integrated on the periphery of the laser device with an isolation region interposed there between. The laser device is composed of an n-DBR mirror, an active region, and a p-DBR mirror and includes a columnar layered structure with its sidewall covered with an insulating film. The photodiode is formed on the substrate and has a circular layered structure wherein an i-GaAs layer and a p-GaAs layer surrounds the laser device with an isolating region interposed between the i-GaAs and p-GaAs layers and the laser device. The diameter of the photodiode is smaller than the diameter of the optical fiber core optically coupled with the optical semiconductor apparatus. Since the laser device and the photodiode are monolithically integrated, the devices do not require optical alignment, and thus, facilitate optical coupling with an optical fiber.
US08680537B2 Nitride semiconductor element and nitride semiconductor wafer
According to one embodiment, a nitride semiconductor element includes a foundation layer, a functional layer and a stacked body. The stacked body is provided between the foundation layer and the functional layer. The stacked body includes a first stacked intermediate layer including a first GaN intermediate layer, a first high Al composition layer of Alx1Ga1-x1N (0
US08680536B2 Non-uniform two dimensional electron gas profile in III-Nitride HEMT devices
A HEMT device has a substrate; a buffer layer disposed above the substrate; a carrier supplying layer disposed above the buffer layer; a gate element penetrating the carrier supplying layer; and a drain element disposed on the carrier supplying layer. The carrier supplying layer has a non-uniform thickness between the gate element and the drain element, the carrier supplying layer having a relatively greater thickness adjacent the drain element and a relatively thinner thickness adjacent the gate element. A non-uniform two-dimensional electron gas conduction channel is formed in the carrier supplying layer, the two-dimensional electron gas conduction channel having a non-uniform profile between the gate and drain elements.
US08680534B2 Vertical light emitting diodes (LED) having metal substrate and spin coated phosphor layer for producing white light
A vertical light-emitting diode (VLED) includes a metal substrate, a p-electrode coupled to the metal substrate, a p-contact coupled to the p-electrode, a p-GaN portion coupled to the p-electrode, an active region coupled to the p-GaN portion, an n-GaN portion coupled to the active region, and a phosphor layer coupled to the n-GaN portion.
US08680533B2 Light-emitting device having light-emitting elements with a shared electrode
A light-emitting device operating on a high drive voltage and a small drive current. LEDs (1) are two-dimensionally formed on an insulating substrate (10) of e.g., sapphire monolithically and connected in series to form an LED array. Two such LED arrays are connected to electrodes (32) in inverse parallel. Air-bridge wiring (28) is formed between the LEDs (1) and between the LEDs (1) and electrodes (32). The LED arrays are arranged zigzag to form a plurality of LEDs (1) to produce a high drive voltage and a small drive current. Two LED arrays are connected in inverse parallel, and therefore an AC power supply can be used as the power supply.
US08680529B2 Semiconductor device and method for manufacturing the same
A semiconductor device includes a pixel electrode and a transistor which includes a first gate electrode, a first insulating layer over the first gate electrode, a semiconductor layer over the first insulating layer, a second insulating layer over the semiconductor layer, and a second gate electrode. The pixel electrode and the second gate electrode are provided over the second insulating layer. The first gate electrode has a region overlapping with the semiconductor layer with the first insulating layer provided therebetween. The second gate electrode has a region overlapping with the semiconductor layer with the second insulating layer provided therebetween. A first region is at least part of a region where the second gate electrode overlaps with the semiconductor layer. A second region is at least part of a region where the pixel electrode is provided. The second insulating layer is thinner in the first region than in the second region.
US08680526B2 Electronic device, method of producing the same, and display device
An electronic device includes: a substrate; a lower electrode which is provided on the substrate and has an edge portion cross-section having a taper angle of 60° or less; a SiO2 film which is provided on the lower electrode, the SiO2 film including hydrogen atoms in a ratio of 3 atomic % or less, and having a refractive index n of 1.475 or less at a wavelength of 650 nm; and an upper electrode which is provided on the SiO2 film and has an overlapping portion with the lower electrode.
US08680524B2 Method of arranging pads in semiconductor device, semiconductor memory device using the method, and processing system having mounted therein the semiconductor memory device
A method of arranging pads in a semiconductor memory device, the semiconductor memory device using the method, and a processing system having mounted therein the semiconductor memory device. The method includes classifying pads provided in a memory chip of the semiconductor memory device into monitoring pads configured for a memory chip test on a wafer, a package pads configured for wire connection in a package, and common pads configured for both the memory chip test on the wafer and wire connection in the package and arranging the monitoring pads and the package pads separately in columns on the memory chip.
US08680523B2 Sensor for semiconductor degradation monitoring and modeling
The present invention provides in-situ positioning of a sensor within each functional block, as well as at critical locations, of a semiconductor system. Sensor quantity and location is optimized for maximum sensitivity to known process variations. The sensor models a behavior of the location in which it is positioned and comprises a plurality of stages connected as a network and a self-digitizer. Each sensor has a mode selection input for selecting a mode thereof and an operational trigger input for enabling the sensor to model the behavior. The model selection input and operation trigger enable the sensor to have an operational mode in which the plurality of sensors are subject to an aging process, as well as a measurement mode in which an age of the plurality of sensors is outputted. Based on the output, one or more functional blocks are modified to reduce semiconductor system gradation in real-time.
US08680518B2 Organic light-emitting diode display device having deep and sky blue sub-pixels
Provided is an organic light-emitting diode (OLED) display device having sub-pixels with four colors. When a B1 sub-pixel that represents deep blue and a B2 sub-pixel that represents sky blue are formed, by using a high efficiency blue organic material to form the same emission material layers in both the B1 and B2 sub-pixels such that a microcavity effect is implemented only in the B2 sub-pixel and a sky blue peak is extracted from the high efficiency blue organic material of the B2 sub-pixel, the emission material layer of the B2 sub-pixel represents sky blue. Therefore, a process of depositing emission material layers is simplified, which leads to a short process time and a reduction of the cost of materials, resulting in improvement in process efficiency of the OLED display device.
US08680517B2 Organic light emitting diode display device and method of manufacturing the same
An organic light emitting diode display device includes: a semiconductor layer on a substrate and including source and drain regions; a first insulating layer on the semiconductor layer; a gate electrode and a first storage electrode on the first insulating layer; a second insulating layer on the gate electrode and the first storage electrode; source and drain electrodes connected with the source and drain regions, respectively; a second storage electrode on the second insulating layer at a location corresponding to the first storage electrode; a third insulating layer on the source and drain electrodes and the second storage electrode; a first metal layer on the third insulating layer and connecting the drain electrode to an anode; and a second metal layer on the third insulating layer at a location corresponding to the second storage electrode.
US08680516B2 Packaging structure and method for OLED
The present invention discloses a packaging structure and method for organic light emitting devices, in which the packaging structure comprises a substrate; an OLED device, which disposing on the substrate; a first transparent protection layer, which forming on the OLED device; and a second transparent protection layer, which forming on the first transparent protection layer.
US08680514B2 Electric energy generator
An electric energy generator may include a semiconductor layer and a plurality of nanowires having piezoelectric characteristics. The electric energy generator may convert optical energy into electric energy if external light is applied and may generate piezoelectric energy if external pressure (e.g., sound or vibration) is applied.
US08680512B2 Graphene transistor with a self-aligned gate
A transistor structure is provided which includes a graphene layer located on an insulating layer, a first metal portion overlying a portion of the graphene layer, a second metal portion contacting and overhanging the first metal portion, a first electrode contacting a portion of the graphene layer and laterally offset from a first sidewall of the first metal portion by a lateral spacing, and a second electrode contacting another portion of the graphene layer and laterally offset from a second sidewall of the first metal portion by the lateral spacing.
US08680511B2 Bilayer gate dielectric with low equivalent oxide thickness for graphene devices
A silicon nitride layer is provided on an uppermost surface of a graphene layer and then a hafnium dioxide layer is provided on an uppermost surface of the silicon nitride layer. The silicon nitride layer acts as a wetting agent for the hafnium dioxide layer and thus prevents the formation of discontinuous columns of hafnium dioxide atop the graphene layer. The silicon nitride layer and the hafnium dioxide layer, which collectively form a low EOT bilayer gate dielectric, exhibit continuous morphology atop the graphene layer.
US08680509B2 Nitride semiconductor device and method of producing the same
A nitride semiconductor device is provided, in which a superlattice strain buffer layer using AlGaN layers having a low Al content or GaN layers is formed with good flatness, and a nitride semiconductor layer with good flatness and crystallinity is formed on the superlattice strain buffer layer. A nitride semiconductor device includes a substrate; an AlN strain buffer layer made of AlN formed on the substrate; a superlattice strain buffer layer formed on the AlN strain buffer layer; and a nitride semiconductor layer formed on the superlattice strain buffer layer, and is characterized in that the superlattice strain buffer layer has a superlattice structure formed by alternately stacking first layers made of AlxGa1-xN (0≦x≦0.25), which further contain p-type impurity, and second layers made of AlN.
US08680503B2 Carbon nano-film reversible resistance-switchable elements and methods of forming the same
Methods of forming a microelectronic structure are provided, the microelectronic structure including a first conductor, a discontinuous film of metal nanoparticles disposed on a surface above the first conductor, a carbon nano-film formed atop the surface and the discontinuous film of metal nanoparticles, and a second conductor disposed above the carbon nano-film. Numerous additional aspects are provided.
US08680497B2 Superhydrophobic electromagnetic field shielding material and method of preparing the same
A superhydrophobic electromagnetic field shielding material includes a curable resin and a carbon material, the superhydrophobic electromagnetic field shielding material including at least two depression patterns on an exposed surface. The at least two depression patterns may include a first depression pattern including a plurality of grooves having a same shape and a second depression pattern including a plurality of grooves having a same shape. The carbon material may be about 3 wt % to about 20 wt % based on the total weight of the superhydrophobic electromagnetic field shielding material.
US08680496B2 System and method for germicidal sanitizing of an elevator or other enclosed structure
A system for sanitizing an enclosed structure has a plurality of sensors, a germicidal ultraviolet light source, and a controller. A first sensor detects the presence of humans or animals within the enclosed structure, and a second sensor detects the position of at least one door of the enclosed structure. The ultraviolet light source provides electromagnetic radiation in the ultraviolet range. The controller receives inputs from the first and second sensors and instructs emission or cessation of emission of the electromagnetic radiation based on the received input.
US08680495B1 Extreme ultraviolet light source
Techniques are described that enhance power from an extreme ultraviolet light source with feedback from a target material that has been modified prior to entering a target location into a spatially-extended target distribution or expanded target. The feedback from the spatially-extended target distribution provides a nonresonant optical cavity because the geometry of the path over which feedback occurs, such as the round-trip length and direction, can change in time, or the shape of the spatially-extended target distribution may not provide a smooth enough reflectance. However, it may be possible that the feedback from the spatially-extended target distribution provides a resonant and coherent optical cavity if the geometric and physical constraints noted above are overcome. In any case, the feedback can be generated using spontaneously emitted light that is produced from a non-oscillator gain medium.
US08680493B2 Radiation conduit for radiation source
A radiation source includes a fuel supply configured to deliver fuel to a plasma emission location for vaporization by a laser beam to form a plasma, and a collector configured to collect EUV radiation emitted by the plasma and direct the EUV radiation towards an intermediate focus. The collector includes a diffraction grating configured to diffract infrared radiation emitted by the plasma. The radiation source includes a radiation conduit located in between the collector and the intermediate focus. The radiation conduit includes an entrance aperture connected by an inwardly tapering body to an exit aperture. The radiation conduit includes an inner portion and an outer portion, the inner portion being closer to the intermediate focus than the outer portion. The inner portion is configured to reflect incident diffracted infrared radiation towards the outer portion.
US08680491B2 Method of controlling ion implantation apparatus
Provided is a method of controlling an ion implantation apparatus 100 which includes: a mass separator 3 for sorting out and outputting ions having a specific mass number and valence from an ion beam IB extracted from an ion source 2; an acceleration tube 4 for accelerating or decelerating the ion beam IB output from the mass separator 3; and an energy separator 5 for sorting out and outputting ions having a specific energy from the ion beam IB output from the acceleration tube 4. The method comprises, during an acceleration mode, controlling an acceleration voltage VA such that it is prevented from becoming 0 kV.
US08680489B2 Lithography method and device
An installation and method for etching at least one wafer coated with an etch-ready, blank photosensitive layer is disclosed. In accordance with an embodiment, the wafer has thickness irregularities, wherein the wafer is arranged to be able to be submitted to irradiation-beam scanning, a sheet transparent to the radiation to which the photosensitive layer is sensitive covers the wafer, and a probe beam intended to reflect on the upper portion of the sheet perpendicularly to the irradiation beam spot on the photosensitive layer is provided.
US08680488B2 System and method for producing and using multiple electron beams with quantized orbital angular momentum in an electron microscope
A system and method for using electron beams with engineered phase dislocations as scanned probes in electron probe beam instruments such as scanning transmission electron microscopes. These types of electron beams have unique properties and can provide better information about a specimen than conventional electron beams. Phase dislocations may be created based on a pattern disposed on a nanoscale hologram, which may be placed in the electron optical column of the electron probe beam instrument. When an electron beam from the instrument is directed onto the hologram, phase dislocations may be imprinted onto the electron beam when electrons are diffracted from these holograms. For example, electron probe beams with spiral phase dislocations may occur. These spiral phase dislocations are formed using a hologram with a fork-patterned grating. Spiral phase dislocations may be used to provide magnetic contrast images of a specimen.
US08680487B2 Charged particle dose simulation device, charged particle beam irradiation device, charged particle dose simulation method, and charged particle beam irradiation method
A simulation device includes an input unit which receives an input of simulation data including material information of the irradiation target and irradiation information of a charged particle beam, and an arithmetic unit which calculates the dose distribution of the charged particle beam in the irradiation target on the basis of simulation data received by the input unit and the dose distribution kernel. The arithmetic unit segments the charged particle beam spread to a predetermined range at an intermediate portion in the traveling direction of the charged particle beam, hypothesizes a plurality of virtual shapes having conical spread with a segmented position as a start point, and calculates the dose distribution of the charged particle beam in the irradiation target on the basis of simulation data received by the input unit and a plurality of virtual shapes of the charged particle beam.
US08680486B2 Biological molecule detecting apparatus and biological molecule detecting method
A biological molecule detecting apparatus capable of highly sensitive measurements is provided. The emission direction of an orientation controlling light beam was periodically switched, to periodically switch the orientation direction of binding molecules 15 within a solution. Components, which are synchronized with the orientation periods of the binding molecules are extracted from fluorescence emitted by fluorescent molecules within the solution, are extracted and detected. Thereby, the concentration of a detection target substance can be accurately measured with a simple configuration.
US08680483B2 Fluorescence detector
A fluorescence detector in which a sample substrate is provided with a structure unit comprising a prism or a diffraction grating. After excitation light falling on the sample substrate is totally reflected at a biomolecule-immobilized face that is located in the opposite side of the structure unit, the structure unit allows the emission of the reflected light therefrom. To ensure multiple visual field measurement, a sample substrate-driving unit is provided to scan the sample substrate.
US08680481B2 Detection apparatus for detecting charged particles, methods for detecting charged particles and mass spectrometer
Embodiments of the invention provide a detection apparatus for detecting charged particles having a secondary particle generator for generating secondary charged particles in response to receiving incoming charged particles, a charged particle detector for receiving and detecting secondary charged particles generated by the secondary particle generator, a photon generator for generating photons in response to receiving secondary charged particles generated by the secondary particle generator, and a photon detector for detecting the photons generated by the photon generator.
US08680480B2 Beam control assembly for ribbon beam of ions for ion implantation
A beam control assembly to shape a ribbon beam of ions for ion implantation includes a first bar, second bar, first coil of windings of electrical wire, second coil of windings of electrical wire, first electrical power supply, and second electrical power supply. The first coil is disposed on the first bar. The first coil is the only coil disposed on the first bar. The second bar is disposed opposite the first bar with a gap defined between the first and second bars. The ribbon beam travels between the gap. The second coil is disposed on the second bar. The second coil is the only coil disposed on the second bar. The first electrical power supply is connected to the first coil without being electrically connected to any other coil. The second electrical power supply is connected to the second coil without being electrically connected to any other coil.
US08680478B2 Radiation detection apparatus and detection system including same
A detection apparatus includes a driving circuit unit in which a plurality of unit circuits each including a first circuit that supplies conducting voltage of a switch element of a pixel based on voltage included in a clock signal to a driving wire in accordance with an initiation signal and a second circuit that supplies non-conducting voltage of the switch element to the driving wire in accordance with a termination signal are provided for the plurality of corresponding driving wires and a control unit that supplies the clock signal to the driving circuit unit. The control unit supplies control voltage to the plurality of unit circuits, and each of the plurality of unit circuits further includes a third circuit that continues to supply the non-conducting voltage to the corresponding driving wire in accordance with the control voltage.
US08680477B2 Non-destructive inspection method and device
A method of non-destructive inspection of a subject body including one or more elements comprises irradiating the subject body with a neutron ray along an axis line passing through a reference point; synchronously detecting gamma rays from directions inclined at equal angles to the axis line at a plurality of measurement points disposed to have equivalent intervals radially from the axis line, respectively; measuring the detected gamma rays in a plurality of energy ranges; determining whether measured values in the respective energy ranges are beyond thresholds; determining energy ranges where all the measured values are beyond the thresholds; analyzing a type of an element from the determined energy ranges; and detecting a location of the analyzed type of the element in the subject body on the basis of the reference point, the respective measurement points, a relative position relative to a surface of the subject body, and the directions.
US08680476B2 Beta radiation monitor and method
A beta radiation monitor (70,90), comprising a gas flow proportional detector (60) for detecting beta radiation emitted by a beta emitter external to the detector; a fill gas supply (51) configured to supply a fill gas to the detector, wherein the fill gas comprises nitrogen; a temperature sensor (72) for measuring temperature; and a controller (64) in communication with the temperature sensor for adjusting an operational parameter of the monitor in accordance with the measured temperature. The operational parameter may comprise a voltage applied across the fill gas, which may be thermistor controlled, or a beta radiation detection threshold of the detector. The fill gas is supplied by a nitrogen generator. The gas flow proportional detector may be a large-area detector.
US08680475B2 Digital X-ray detector assembly with elastomeric backscatter shield
Portable digital X-ray detectors are provided. One X-ray detector includes an outer assembly and a detector assembly disposed within the outer assembly. The detector assembly includes an imager having a scintillator that converts radiographic energy to light and a detector array having one or more detector elements that detect the light from the scintillator. The detector assembly also includes electronic circuitry mounted on at least one printed circuit board and adapted to control operation of the imager during data acquisition and readout. Further, an elastomeric assembly is disposed between the imager and the electronic circuitry, and the elastomeric assembly is configured to absorb backscattered X-rays that pass through the imager or deflect off of a portion of the outer assembly during an X-ray exposure.
US08680473B2 Multiply-sampled CMOS sensor for X-ray diffraction measurements with corrections for non-ideal sensor behavior
Readout noise for each pixel in a CMOS Active Pixel Sensor is reduced by a five step process in which the pixel charge data from the sensor is non-destructively sampled at a plurality of times during a sensor frame time period and corrected for gain variation and nonlinearity. Then fixed pattern and dark current noise is estimated and subtracted from the corrected pixel charge data. Next, reset noise is estimated and subtracted from the pixel charge data. In step four, a model function of charge versus time is fit to the corrected pixel charge data samples. Finally, the fitted model function is evaluated at frame boundary times.
US08680470B2 Radiographic imaging device, computer-readable medium storing program for controlling radiographic imaging device, and method for controlling radiographic imaging device
The present invention provides a radiographic imaging device, a computer-readable medium storing a program for controlling a radiographic imaging device, and a method for controlling a radiographic imaging device, that may suppress feed-through without narrowing a dynamic range. Namely, a control section outputs control signals via scan lines to gates of TFT switches to perform control in such a way that the timing when a TFT switch n−1 of a pixel n−1 is switched to an OFF state and the timing when a TFT switch n of a pixel n is switched to an ON state become simultaneous timings, or timings that can be regarded substantially simultaneous even though the time period in which the TFT switch n is in an ON state and part of the time period in which the TFT switch n−1 is in an ON state overlap.
US08680465B2 Charged particle beam apparatus and film thickness measurement method
A charged particle beam apparatus of the present invention comprises a transmission electron detector (113; 206) having a detection portion divided into multiple regions (201 to 205; 301 to 305), wherein a film thickness of a sample is calculated by detecting a transmission electron beam (112) generated from the sample when the sample is irradiated with an electron beam (109), as a signal of each of the regions in accordance with scattering angles of the transmission electron beam, and thereafter calculating the intensities of the individual signals. According to the above, there is provided a charged particle beam apparatus capable of performing accurate film thickness monitoring while suppressing an error due to an external condition and also capable of processing a thin film sample into a sample having an accurate film thickness, which makes it possible to improve the accuracy in structure observations, element analyses and the like.
US08680463B2 Linear ion trap for radial amplitude assisted transfer
Systems, methods and apparatus for radial amplitude assisted transfer (RAAT) in mass spectrometers are provided in which ions for RAAT are accelerated along a longitudinal axis of a mass spectrometer in order to decrease the magnitude of excitation energy of radially excited ions in an ion trap that allows the radially excited ions to exit the ion trap. Hence, the radially excited ions exit the ion trap with reduced radial energy thereby decreasing the exit angle of the radially exited ions from the ion trap. Furthermore, combined forces on the ions are such that radially excited ions exit the ion trap while unexcited ions remain in the ion trap.
US08680462B2 Curved heated ion transfer optics
An ion optics assembly is formed by four quarter-circular profile elements, all of which are attach to the same reference plate. Consequently, all four elements remain aligned to the same reference plate. The four elements form a quarter-circular channel with quarter-circular quad electrodes. The quad electrodes receive electrical potential to form the field required to focus and maintain the ions at the center of the channel. Quarter-circular insulators are provided on all sides of the channel so as to seal the channel over its length from the interior of the mass spectrometer. A heater is provided at the entrance to the ion transfer optics, to prevent accumulation of ions on the poles. A thermal break is provided in the quad, so as to enable maintaining the front of the quad heated and the rest of the quad cooler.
US08680460B2 Converging-diverging supersonic shock disruptor for fluid nebulization and drop fragmentation
A disruptor apparatus comprises a nozzle comprising: a converging section; a diverging section; and a throat between the converging section and the diverging section. The disruptor apparatus also comprises a holder configured to receive a fluid conduit, which comprises an outlet located in the converging section; and a channel disposed about the holder and configured to guide a gas past the outlet of the fluid conduit, through the converging section, through the throat and into the diverging section where the gas travels at supersonic speed and establishes a standing shock wave in the diverging section. A mass spectrometer and a method are also described.
US08680455B2 Plasmonic light collectors
An electronic device may be provided with imaging modules or communications modules. Imaging modules and communications modules may be improved with the use of plasmonic light collectors. Plasmonic light collectors exploit the interaction between incoming light and plasmons in the plasmonic light collector to redirect the path of the incoming light. Plasmonic light collectors may be used to form lenses for image pixels in an imaging module or to form light pipes or lenses for use in injecting optical communications into a fiber optic cable. Plasmonic lenses may be formed by lithography of metallic surfaces, by implantation or by stacking and patterning of layers of materials having different dielectric properties. Plasmonic image pixels may be smaller and more efficient than conventional image pixels. Plasmonic light guides may have significantly less signal loss than conventional lenses and light guides.
US08680454B2 Backside-illuminated (BSI) pixel including light guide
Implementations of a pixel including a substrate having a front side, a back side, and a photosensitive region formed on or near the front side, a dielectric layer formed on the front side, and a metal stack having a bottom side and a top side, the bottom side being on the dielectric layer. A light guide is formed in the dielectric layer and the metal stack and extending from the front side of the substrate to the top side of the metal stack, the light guide having a refractive index equal to or greater than the refractive index of the substrate. Other implementations are disclosed and claimed.
US08680453B2 Imaging device with charge collection zone and charge storage zone
Imaging device comprising at least one photosite comprising a charge storage semiconductor zone, a charge collection semiconductor zone and transfer means designed to permit charge transfer between the charge storage zone and the charge collection zone, characterized in that the charge storage semiconductor zone comprises a lower semiconductor zone and a conduction channel buried beneath the upper surface of the photosite and connecting said lower semiconductor zone to the charge collection zone.
US08680452B2 Optically controlled motorized control device
Methods and apparatus are provided for a control device and control device operation. In one embodiment a control device includes a slider configured to support a control knob, a rack coupled to the slider and configured to linearly displace the slider. The rack including slots. The control device may further include a drive element configured to displace the rack and position the control knob, and an optical detection module configured to detect position of the control knob based on one or more optical signals detected relative to slots of the rack. According to another embodiment, a control console is provided including control devices.
US08680449B2 Cooking apparatus
A cooking apparatus is provided. The cooking apparatus includes a cooking cavity, an upper space formed above the cooking cavity, lateral side spaces formed to at opposite lateral sides of the cooking cavity, a rear space formed behind the cooking cavity, and a lower space formed below the cooking cavity. A fan provided in the rear space generates a cooling flow that cools components housed in the rear space. A cooling flow path extends from the rear space and into the upper space and lateral side spaces. Flow from the upper space enters the door to cool the door and is exhausted through a lower portion of the door. Flow from the lateral side spaces, which includes an exhaust flow from the cooking cavity, is guided to the lower space and exhausted. In this manner, the cooking apparatus can be completely cooled and cooking odors and heat appropriately exhausted by the cooling fan positioned in the rear space.
US08680447B2 Microwave popcorn bag construction with seal arrangement for containing oil/fat, microwave popcorn product, and methods
Microwaveable popcorn arrangements are provided, the arrangement being a bag having a popcorn charge of popcorn kernels and oil/fat component therein. The arrangements include folded bags having preferred, internal, seal and/or adhesive field configurations. The preferred configurations inhibit the undesired flow of oil/fat from the popcorn charge. Microwave popcorn products and methods of preparation and use, are provided.
US08680442B2 Systems and methods for a temperature-controlled electrical outlet
Certain embodiments of the present invention provide an electrical outlet including a power output adapted to provide electricity to an electrically coupled device, a switch adapted to activate and deactivate the power output, a temperature sensor adapted to detect a temperature, and a control unit in communication with the switch and the temperature sensor. The control unit is adapted to control the power output using the switch based at least in part on the temperature detected by the temperature sensor.
US08680438B2 Combination urn and warming plate and methods of using same
The present invention generally concerns a Combination Urn and Hot Plate for supplying heat to both liquids and solids, typically beverages and food, for heating or keeping same warm.
US08680436B2 Hand grip
In order to improve a hand grip for handlebar-steered vehicles, comprising a grip covering, made of a grip-covering material, and an accommodating space which extends, by way of its longitudinal extent, from a plug-in opening in a plug-in direction for a grip component of the handlebar, such that it is seated optimally on the grip component of the handlebar, it is proposed that the accommodating space has at least one wall segment which has at least one abutment surface and at least one recess, the abutment surface having surface sub-regions adapted to an outer surface of the grip component, and the at least one recess being disposed between the surface sub-regions and extending approximately parallel to the plug-in direction, as an adhesive reservoir.
US08680431B2 Device and method to control a power source
Apparatus, devices, and methods for providing a voltage reduction capability in a welding power source for safety purposes. The resistive load and the output voltage of the welding power source output are monitored and compared to predefined or preselected threshold values to generate a load condition signal and an output voltage condition signal (e.g., logic signals). The load condition signal and the output voltage condition signal serve as inputs to a voltage reduction device control logic which generates control signals to enable and disable the input and output of the welding power source according to the defined control logic. As a result, an extra measure of safety in preventing electrical shock is provided to users of the welding power source during hazardous operating conditions.
US08680427B2 Uniform large-grained and gain boundary location manipulated polycrystalline thin film semiconductors formed using sequential lateral solidification and devices formed thereon
A device on a supporting substrate is provided including a semiconductor film, having two or more rectangular crystalline regions spaced from each other, wherein each of the two or more rectangular crystalline regions comprises one single crystal region. The device can further include two or more thin-film transistors, wherein each of the two or more thin-film transistors comprises one or more active-channel regions. Each of the one or more active-channel regions can comprise at least one of said two or more rectangular crystalline regions. The device can further include an integrated circuit which comprises of the two or more thin-film transistors.
US08680425B2 Plasma arc torch having an electrode with internal passages
An electrode for a plasma arc cutting torch which minimizes the deposition of high emissivity material on the nozzle, reduces electrode wear, and improves cut quality. The electrode has a body having a first end, a second end in a spaced relationship relative to the first end, and an outer surface extending from the first end to the second end. The body has an end face disposed at the second end. The electrode also includes at least one passage extending from a first opening in the body to a second opening in the end face. A controller can control the electrode gas flow through the passages as a function of a plasma arc torch parameter. Methods for operating the plasma arc cutting torch with the electrode are disclosed.
US08680417B2 Operation apparatus
An operation apparatus inhibits separation of a holding member for holding an operation knob from a circuit board. A holding member holding a rotation operation knob so as to be rotatable includes a latched portion capable of insertion through a through-hole formed on a circuit board and also capable of flexure deformation in a specified line parallel to the circuit board. On a rear end of the latched portion, a latched projection is provided projecting to a first direction of the specified line. Accompanying flexure deformation of the latched portion in a second direction opposite to the first direction, the latched projection is able to pass through the through-hole by displacing a predetermined amount in the second direction. The rear cover includes a deformation regulator contacting the latched projection from the second direction and regulates displacement of the latched projection in the second direction to less than the pre-determined amount.
US08680415B2 Micro-switch employing lever principle
A labor-saving micro-switch comprises a housing, a press member located on the housing, an actuation member located in the housing and a driven member located between the press member and actuation member. The press member is depressible to move reciprocally in a displacement inside the housing. The driven member includes a pivotal portion hinged on the housing in a swivelable manner, a force-receiving portion opposite to the pivotal portion in the displacement and a force-applying portion driven by the force-receiving portion and movable about the pivotal portion serving as a fulcrum to press the actuation member. The driven member drives the actuation member to switch between a first conductive state and a second conductive state through a lever principle. The micro-switch thus formed can achieve higher sensitivity and reduce production cost.
US08680413B2 Illuminating push-button device and portable terminal
An illuminating push-button device includes a key-top part having a key-top surface and a first protrusion that protrudes from a back side of the key-top surface. The device also includes a key rubber part made of a transparent or semi-transparent elastic material and having a second protrusion that receives the first protrusion, the second protrusion being oriented in a common direction as the first protrusion. A switching device is included that opposes the second protrusion and is configured to be actuated in response to the key-top part being depressed. A light-source element emits light from a light-emitting surface and cooperates with a light-blocking sheet disposed between the light-source element and key rubber part and covers at least a portion of the light-emitting surface of the light-source element and has a loose hole through which the second protrusion of the key rubber part is passed.
US08680412B2 Footswitch operable to control a surgical system
The present invention provides a surgical footswitch that includes a base, a pedal, an encoder assembly, a wireless interface, and an internal power generator. The pedal mounts upon the base and pivots. The encoder assembly couples to the pedal. As the pedal pivots, the encoder assembly translates the mechanical signal of the pedal into a control signal based on the pedals position and/or orientation. The wireless interface couples the encoder assembly to receive the control signal. The wireless interface also couples the surgical footswitch to a surgical console operable to control and direct surgical equipment. The wireless interface passes the control signal from the encoder to the surgical console, which then directs the surgical equipment based on the control signal. This wireless interface eliminates the tangle of wires or tethers, which may be a hazard in the surgical theater. The internal power generator translates footswitch movement into stored energy to eliminate potential failures of the footswitch during a procedure and overcome the need to replace batteries within the footswitch.
US08680410B2 Self-locking ignition switch
A self-locking ignition switch for engagement with a lock housing driver of a motor vehicle having a key activated ignition system. The ignition switch includes a switch mechanism that is moveable between multiple key positions. The switch mechanism is enclosed within a casing, and the casing including a collar extending from a side wall of the casing and terminating at a distal end. The collar further has portions defining an interference and portions defining a side opening extending from the distal end toward the side wall of the casing. A slide member positioned within the collar and biased by a biasing member so as to engage the interference. Engagement between the interference and the slide member forms a lockout that fixes the switch mechanism in an installation configuration and prevents movement of the portions of the switch mechanism between the multiple key positions prior to installation.
US08680408B2 Electronic scale for measuring weight using two measurements and a processor therefor
An electronic scale functions in a normal and a high sensitivity measurement regions. The weights of mother alone and mother plus infant are measured in the high sensitivity region. The difference between the two measurements is the weight of infant alone, which is displayed with a finer scale interval than the normal one. The high sensitivity region is automatically shifted for covering the two measurements. The degree of shift is stored to correct the absolute mother weight. The infant weight is transmitted to a mobile phone, which displays growth curve of infant in comparison with a statistics growth curves provided by a server through the internet. The infant weight is uploaded to the server for incorporation into the statistics. The statistics is based on data gathered form a plurality of mobile phones, which are each authenticated to increase reliability of the statistics against false weight data upload.
US08680407B1 Modular enclosure assembly for terminals wiring and distribution
A modular enclosure assembly comprising: an upper and lower enclosure subassemblies, interconnected by a partial interpenetration, and a pair of hinged panel subassemblies for opening/closing the inner space of the enclosure subassemblies. Each of the enclosure subassemblies incorporates a back base plate having a first interpenetrating zone, located at an end of a lower left side of the back base plate, and a second interpenetrating zone, located at an end of a lower right side of the back base plate and juxtaposed with the first interpenetrating zone. The second interpenetrating zone incorporates a slat partially superposed on a rear surface of the back base plate where and with which this second interpenetrating zone forms a monoblock structure and from which the slat extends downwardly, beyond the rear surface of the back base plate.
US08680406B2 Radiation-proof laminate for electronic devices and method for embedding the same into a case
A radiation-proof laminate for electronic devices has: a substrate layer consisting of an electrically conductive material, and a first radiation barrier layer formed on the substrate layer, wherein the first radiation barrier layer comprises 50 wt % to 70 wt % of rubber-based heat-bonding adhesive compound in the form of powder or liquid, 5 wt % to 20 wt % of aluminum powder, 5 wt % to 20 wt % of copper powder, and 5 wt % to 20 wt % of silver powder; wherein the aluminum, copper, and silver powder are mediated by the rubber-based heat-bonding adhesive compound to disperse and form a mesh-like distribution. The radiation-proof laminate can absorb electromagnetic radiation from the electronic device and redirect RF radiation while maintaining the RF signal strength not to be substantially affected or attenuated by the radiation-proof laminate, to maintain the network connection performance of the electronic device. A method for embedding the radiation-proof laminate into a case of the electronic device is also provided.
US08680404B2 Printed circuit board including via pad with concavo-convex patterns and method of manufacturing the same
The present invention provides a printed circuit board including: a circuit pattern formed on a first insulating layer; a via pad disposed on the first insulating layer by being spaced apart from the circuit pattern, formed on a lower surface, where a via hole is formed, to have a cross section larger than that of the via hole, and having concavo-convex patterns; a second insulating layer formed on the via pad where the via hole is not formed and on the circuit pattern; and a copper foil layer formed on the second insulating layer and the via hole, and a method of manufacturing the same.
US08680403B2 Apparatus for broadband matching
An apparatus is provided. The apparatus comprises a substrate and a circuit trace. The substrate includes a region that is adapted to receive a discrete component, a metal layer, a dielectric layer formed over the metal layer, a window formed in the metal layer that underlies the region, and a conductive strap that extends across the window. The circuit trace is formed on the dielectric layer and is discontinuous across the region.
US08680400B2 Visual cable identification
A cable is made visually identifiable. The visually identifiable cable includes an electrically illuminable outer sheathing. At least one internal tangible transmission interface medium is internally disposed in the electrically illuminable outer sheathing.
US08680399B2 Cable insulation with reduced electrical treeing
Treeing is suppressed in cables through the use of an insulation layer that includes a polyolefin polymer and an additive with delocalized electron structure. The additive can be a carotenoid, carotenoid analog, a carotenoid derivative, a conducting polymer or a combination of two or more such materials.
US08680396B2 Oil-cooled equipment harness
An oil-cooled equipment harness includes a shielded wire including a conductor, a shielding layer on a periphery of the conductor, and a flexibility, a terminal fitting enclosing a front end part of the shielded wire, a housing enclosing a periphery of the shielded wire a predetermined distance away from the terminal fitting such that shielded wire is exposed from the terminal fitting, the housing including a flange, a first oil entry-preventing means disposed at a space between the shielded wire and the terminal fitting for preventing oil in the shielding case from entering into the conductor, and an oil leak-preventing means disposed at a space between the housing and the shielding case for preventing the oil in the shielding case from leaking out of the shielding case. The terminal fitting and the housing are relatively movable by the shielded wire exposed at between the terminal fitting and the housing.
US08680395B2 High speed data cable using an outer braid to carry a signal
A high speed video cable carries signals according to the High-Definition Multimedia Interface (HDMI), and includes a raw cable and may include a boost device. The raw cable includes coaxial lines which are covered by an outer metallic braid. Each of four high speed video signals is carried on the inner conductors of a pair of coaxial lines. Lower speed signals are carried on the galvanically or capacitively coupled shields of a pair of coaxial lines, as well as the braid of the cable.
US08680391B2 Solar concentrator configuration with improved manufacturability and efficiency
A solar concentrator comprises a pair of concentric reflectors having a spindle toroid geometry for focusing the collected solar radiation into a ring-shaped focal area, as opposed to the “point” or “line” focus of prior art configurations. In a preferred embodiment, each reflector is formed of a plurality of curved petals that are disposed in a contiguous, keystone arrangement that requires no additional fixturing to hold the petals in place. Such an arrangement reduces the weight, complexity and cost of the final solar concentrator structure.
US08680389B2 Pickup device and electric stringed musical instrument using the pickup device
A pickup device mountable on a body of an electric stringed musical instrument and configured to convert vibrations of strings of the musical instrument into electric signals, including: at least one magnet each being disposed near one of the strings when the pickup device is mounted; a coil wound around the magnet; and a magnetic attaching member which is conductably connected to the coil and which can be magnetized, wherein the magnetic attaching member is constituted by a magnet which is magnetically attachable to an attachment member provided on a surface of the body, wherein the attachment member is conductably connected to at least one electric component provided on the body, and wherein the magnetic attaching member is configured such that an electrically conductive state can be established between the magnetic attaching member and the attachment member when the magnetic attaching member is magnetically attached to the attachment member.
US08680387B2 Systems and methods for composing music
Generating a musical composition from one or more portions of one or more performances of one or more musical compositions included in a database is disclosed. The method and system include selecting a portion of a pre-recorded composition based on a degree of similarity with the component of the composition that is input; portions that are musically similar but not musically the same as the component may be selected for addition to the composition. The degree of similarity may be based on a ChordScore and/or a ScaleScore of the retrieved portion of the pre-recorded compositions. A ChordScore is generated by comparing chord tones of one or more chords in the pre-recorded portion with chord tones of the input component. A ScaleScore is generated by comparing tones of one or more notes in the pre-recorded portion with tones in a harmonic scale associated with the input component's chords.
US08680386B2 Signal processing device, signal processing method, and program
A signal processing device that identifies a piece of music of an input signal by comparing the input signal with a plurality of reference signals including only a piece of music includes a weight distribution generating section that generates a weight distribution corresponding to a likeness to music in regions of the input signal transformed into a time-frequency domain, and a similarity calculating section that calculates degrees of similarity between a feature quantity in the regions of the input signal transformed into the time-frequency domain and feature quantities in the regions of the reference signals transformed into the time-frequency domain on the basis of the weighting based on the weight distribution.
US08680383B1 Electronic hymnal system
An electronic hymnal system comprises a music stand and a hymnal display. The display is capable of playing the hymns to let users get familiar or practice the hymns while viewing the scores and lyrics in different zoom level according to user's preference. The device comprises a touch screen on the front of the device, a power ON/OFF button, a SD card slot, a disk input slot, a front cover attached to the device, a battery compartment, an earphone port, volume control button and battery charge port. The user can disable the function of playing the hymns, only review the score and lyrics in a group gathering situation.
US08680380B1 Maize variety X6N704
A novel maize variety designated X6N704 and seed, plants and plant parts thereof, produced by crossing Pioneer Hi-Bred International, Inc. proprietary inbred maize varieties. Methods for producing a maize plant that comprises crossing maize variety X6N704 with another maize plant. Methods for producing a maize plant containing in its genetic material one or more traits introgressed into X6N704 through backcross conversion and/or transformation, and to the maize seed, plant and plant part produced thereby. This invention relates to the maize variety X6N704, the seed, the plant produced from the seed, and variants, mutants, and minor modifications of maize variety X6N704. This invention further relates to methods for producing maize varieties derived from maize variety X6N704 and to the maize varieties derived by the use of those methods.
US08680376B2 Soybean variety A1026766
The invention relates to the soybean variety designated A1026766. Provided by the invention are the seeds, plants and derivatives of the soybean variety A1026766. Also provided by the invention are tissue cultures of the soybean variety A1026766 and the plants regenerated therefrom. Still further provided by the invention are methods for producing soybean plants by crossing the soybean variety A1026766 with itself or another soybean variety and plants produced by such methods.
US08680371B1 Soybean variety XBP14002
A novel soybean variety, designated XBP14002 is provided. Also provided are the seeds of soybean variety XBP14002, cells from soybean variety XBP14002, plants of soybean XBP14002, and plant parts of soybean variety XBP14002. Methods provided include producing a soybean plant by crossing soybean variety XBP14002 with another soybean plant, methods for introgressing a transgenic trait, a mutant trait, and/or a native trait into soybean variety XBP14002, methods for producing other soybean varieties or plant parts derived from soybean variety XBP14002, and methods of characterizing soybean variety XBP14002. Soybean seed, cells, plants, germplasm, breeding lines, varieties, and plant parts produced by these methods and/or derived from soybean variety XBP14002 are further provided.
US08680369B2 Sunn hemp cultivars capable of producing seed within the continental united states
Sunn hemp plants capable of flowering and producing seed when grown in the continental United States are provided. Two plant varieties capable of flowering and producing seed when grown in the continental United States, named AU Golden and AU Durbin, are described herein.
US08680366B2 Nanocarrier based plant transfection and transduction
The present invention provides a novel method for the transduction and/or transfection of plant cells. Cell-penetrating peptides (CPPs) have been successfully employed as nanocarriers to deliver proteins and oligonucleotides to single plant cell microspores as well as multi-cellular zygotic embryos. The efficiency of CPP internalization and further delivery of a macromolecular cargo comprising a protein and/or an oligonucleotide can be enhanced by permeabilization of the zygotic embryos.
US08680365B2 Cauliflower plants having a long stem
The present invention relates to novel brassica plants, in particular to novel cauliflower plants. In one embodiment, the novel cauliflower plants provided herein comprise a long stem and are suitable for mechanical harvesting. The application also further discloses seeds the cauliflower plants of the present invention and parts thereof, for example pollen, ovules and curds. The application also further discloses methods of using a plant of instant invention, such as methods of producing a cauliflower curd of the instant invention, and methods of harvesting the curds of plants of the instant invention.
US08680364B2 Soybean genes for resistance to Aphis glycines
Aphis glycines resistance (RAG) genes are provided by this invention, along with methods for identifying their presence using marker-assisted selection. Varieties of G. max and G. soja having resistance to A. glycines have been identified. The RAG genes, as well as the methods, aphid-resistant varieties, and markers disclosed herein may be used to breed new elite lines expressing soybean aphid resistance.
US08680363B2 Insect resistant and herbicide tolerant soybean event 9582.814.19.1
Soybean event 9582.814.19.1, wherein the event comprises genes encoding Cry1F, Cry1Ac (synpro), and PAT, affording insect resistance and herbicide tolerance to soybean crops containing the event, and enabling methods for crop protection and protection of stored products.
US08680352B2 Methods for producing linear alkylbenzenes, paraffins, and olefins from natural oils and kerosene
A method for producing a linear paraffin product from natural oil and kerosene includes providing a first feed stream comprising kerosene, pre-fractionating the first feed stream to produce a heart cut paraffin stream comprising paraffins in a heart cut range, and combining the heart cut paraffin stream with a second feed stream comprising natural oil to form a combined stream. The method further includes deoxygenating the natural oil and fractionating the combined stream to remove paraffins that are heavier than the heart cut range.
US08680351B2 Process for increasing benzene and toluene production
A process for reforming a hydrocarbon stream is presented. The process involves splitting a naphtha feedstream to at least two feedstreams and passing each feedstream to separation reformers. The reformers are operated under different conditions to utilize the differences in the reaction properties of the different hydrocarbon components. The process utilizes a common catalyst, and common downstream processes for recovering the desired aromatic compounds generated.
US08680350B2 Process for hydrogenating unsaturated hydrocarbons in the presence of catalysts containing copper and zinc
Unsaturated hydrocarbons are hydrogenated over catalysts which comprise copper and zinc and whose active composition, in unreduced form, consists essentially of from 10 to 95% by weight of copper oxide, calculated as copper(II) oxide (CuO), from 5 to 90% by weight of zinc oxide (ZnO), optionally from 0.1 to 50% by weight of zirconium dioxide (ZrO2) and optionally from 0.1% by weight to 50% by weight of Al2O3, the proportions by weight adding up to 100% by weight.
US08680342B2 Process for recovering alcohol produced by hydrogenating an acetic acid feed stream comprising water
Purifying and/or recovery of ethanol from a crude ethanol product obtained from the hydrogenation of acetic acid from an feed stream comprising water. The presence of water does not significantly impact acid conversion or selectivity to ethanol. Further the addition of water allows for improved recovery of ethanol.
US08680338B2 Low-VOC polyamino alcohols
A method for adjusting pH in an aqueous coating composition having an initial pH less than 7 by adding to the aqueous coating composition a compound having formula (V) wherein R2 and R3 independently are hydrogen, methyl, ethyl, hydroxymethyl, or R2 and R3 combine with a carbon to which they are attached to form a five-membered or six-membered saturated carbocyclic ring; R4 is hydrogen or C1-C4 alkyl; R5 is hydrogen, methyl, ethyl or hydroxymethyl; R6 is hydrogen, hydroxyethyl, C1-C10 alkyl or —CH2C(R5)(N(R7)2)CH2OH; and R7 is hydrogen or methyl.
US08680337B2 Process for the production of amides
The present invention relates to a process for the preparation of compounds of formula I wherein R1 and R2 are each independently of the other hydrogen or C1-C5alkyl and R3 is CF3 or CF2H, by a) reaction of a compound of formula II wherein R1 and R2 are as defined for formula I, with at least one reducing agent to form a compound of formula III wherein R1 and R2 are as defined for formula I, and b) reaction of that compound with at least one reducing agent to form a compound of formula IV wherein R1 and R2 are as defined for formula I, and (c) reaction of that compound with a compound of formula V wherein Q is chlorine, fluorine, bromine, iodine, hydroxy or C1-C6alkoxy and R3 is as defined for formula I, to form the compound of formula I; and to novel intermediates for use in that process.
US08680333B2 Process for the preparation of aromatic formamides
The invention relates to a process for the preparation of formamides by reacting aromatic amines with a formic acid ester in the presence of a catalyst, wherein the catalyst is a phosphorus-containing acid or a Lewis-acidic metal salt.
US08680332B2 Disubstituted-aminodifluorosulfinium salts, process for preparing same and method of use as deoxofluorination reagents
The invention relates to disubstituted-aminodifluorosulfinium salts represented by the formula (I). Processes for preparing same and methods of use as deoxofluorinating reagent is also provided.
US08680325B2 Process for preparing 2,5-dihydroxyterephthalic acid
The present invention provides a process for preparing 2,5-dihydroxyterephthalic acid which comprises reacting a dialkali metal salt of hydroquinone with carbon dioxide in a reaction medium in the presence of a potassium salt represented by formula (I): CnH2n+1COOK  (I) wherein n is an integer of 1-17. According to the process for preparing 2,5-dihydroxyterephthalic acid of the present invention, 2,5-dihydroxyterephthalic acid can be produced both safely and at a low cost under industrially advantageous conditions. Further, the process according to the present invention causes less damage to reaction equipment and the like.
US08680319B2 Method for producing antifolate agents having glutamic acid part in their structure
A method for producing antifolate agents having glutamic acid part in their structure is developed by protecting carboxyl groups of glutamic acid or its N-substituted derivatives as cyanomethyl ester to give compounds of formula (II) which are hydrolyzed under very mild conditions to afford antifolate agents in high yield with high analytical and optical purity.
US08680318B1 Citric acid esters
The current invention is drawn to a series of citrate esters having high melting domains and liquid domains at room temperature. This that results in an ability to alter hardness, melt point and skin feel, making outstanding waterproofing and emollient properties when applied to skin.
US08680317B2 Processes for making ethyl acetate from acetic acid
A process for hydrogenating acetic acid to form of ethyl acetate and mixtures of ethyl acetate and ethanol. The hydrogenation is done in the presence of catalyst, preferably on a support that optionally includes a support modifier.
US08680307B2 Complexes and method for synthesis of group 6 organometallics grafted on anions, and use thereof in an olefin metathesis method
Novel group 6 organometallic compounds, supported on anions by means of at least one covalent metal-oxygen bond, are obtained by reaction of at least one borate or aluminate comprising at least one hydroxy group with at least one compound of a group 6 transition metal. These compounds are used in a catalytic composition utilized in an olefin metathesis method.
US08680303B2 Epoxidation catalysts
The present invention generally relates to methods for the synthesis of catalysts, including epoxidation catalysts, and related compounds and catalyst compositions. Embodiments described herein may provide efficient processes for providing catalysts (e.g., epoxidation catalysts) in large quantities and using simplified methods.
US08680301B2 Lipase activity inhibitors containing high-molecular weight polyphenol fractions, tea extracts, and processes for producing the same
There are provided foods and beverages that will suppress the absorption of dietary lipids, thereby suppressing the rise of triglyceride in blood. High-molecular weight polyphenol fractions recovered from oolong tea are added to foods or beverages as an active ingredient for inhibiting lipase activity. The foods and beverages of the present invention are safe and their inherent flavor has not been impaired; hence, they may be taken in routinely so that the lipase inhibitory action of the high-molecular weight polyphenol fractions will suppress the rise of triglyceride in blood and prevent obesity.
US08680293B2 Substituted CC-1065 analogs and their conjugates
This invention relates to novel agents that are analogs of the DNA-alkylating agent CC-1065 and to their conjugates. Furthermore this invention concerns intermediates for the preparation of said agents and their conjugates. The conjugates are designed to release their (multiple) payload after one or more activation steps and/or at a rate and time span controlled by the conjugate in order to selectively deliver and/or controllably release one or more of said DNA alkylating agents. The agents, conjugates, and intermediates can be used to treat an illness that is characterized by undesired (cell) proliferation. As an example, the agents and the conjugates of this invention may be used to treat a tumor.
US08680288B2 Pyridin-2yl sulfanyl acid esters and process for the preparation thereof
The present invention relates to Pyridin-2-yl sulfanyl acid ester compounds having antiinflammatory properties. The present invention particularly relates to novel anti-inflammatory heterocyclic acid esters of Pyridin-2-yl sulfanyl having the structure of general formula 1 which have been screened for their antiinflammatory activity with respect to inhibition of adhesion of neutrophils, isolated from human peripheral blood, onto the surface of human umbilical vein endothelial cells (HU-VEC) as a result of inhibition of the cytokine-stimulated expression of cell adhesion molecule ICAM-1. The compound RS—Z, 3-(Pyridin-2-yl sulfanyl)-propionic acid pentyl ester (structure 1a, R1=H, R2=H, R3=CH2-COOC5H11) was found to be most effective for ICAM-1 and neutrophil adhesion inhibition and was found to effectively alleviate inflammation mediated by excessive leukocyte infiltration leading to inflammatory disorders or like conditions, such as acute lung injury and acute respiratory distress syndrome in mice.
US08680287B2 Methods and devices for the production of cyanopyridines
Subject of the invention is a method for the production of a cyanopyridine, wherein (A) a gaseous reaction product comprising the cyanopyridine is produced in a reactor, (B) the gaseous reaction product is quenched with water in a column (2) and a gaseous phase is obtained, which is depleted from at least a portion of the cyanopyridine, (C) the gaseous phase is transferred to a condenser, in which a condensate is obtained, and the gaseous phase is depleted from at least a portion of the water, and (D) the gaseous phase from the condenser is passed through at least one heat exchanger. Another subject of the invention is a device for carrying out the invention.
US08680284B2 Preparation process of the sodium salt of esomeprazole
A preparation process of esomeprazole sodium substantially free of sulfone impurity including the steps of: a) combining either esomeprazole with a (C3-C8)-ketone or a mixture thereof, a sodium alkoxide, and a (C1-C5)-alcohol, or esomeprazole sodium with a (C3-C8)-ketone or a mixture thereof and a (C1-C5)-alcohol; and b) recovering the esomeprazole sodium formed from the reaction media by filtration.
US08680280B2 Process for the manufacturing of CRR inhibitors
The present invention relates to a process for preparing CCR3 inhibitors of formula 1, wherein R1 is H, C1-6-alkyl, C0-4-alkyl-C3-6-cycloalkyl, C1-6-haloalkyl; R2 is H, C1-6-alkyl; X is an anion selected from the group consisting of chloride or ½ dibenzoyltartrate j is 1 or 2.
US08680279B2 Compounds for the treatment of neurological disorders
Provided are compounds, pharmaceutical compositions and methods of treatment or prophylaxis of certain neurologic disorders, including disorders related to NMDA receptor activation, neuropsychiatric disorders, neurodegenerative disorders and other neurologic diseases, disorders and related conditions. The compounds are of the Formulas I and Ia-Ij as described herein.
US08680278B2 Enantioselective process for preparing a substituted alkanoic acid
The present invention is directed to a process for enantioselectively preparing substituted piperidine alkanoic acid integrin antagonist compounds.
US08680272B2 3-arylethynyl substituted quinazolinone compounds
The present invention provides 3-arylethynyl substituted quinazolinone compounds of formula (A) as potential anticancer agents against sixty human cancer cell lines. R1═H, OH, OCH3; R2═H, OH, CH3, OCH3, NO2; R3═H, OH, OCH3, F, Cl; R2+R3=—OCH2O—; R4═H, OH, CH3, OCH3; R5═H, OH, CH3, OCH3; R6═H, OCH3.
US08680269B2 Pesticidal compositions
The present invention concerns novel heteroaryl-N-aryl thiosemicarbazones and their use in pest control, as insecticides and acaπcides This invention also includes preparation of the pesticide compositions containing the compounds, and methods of controlling insects using the compounds.
US08680266B2 Metallocorroles
Metallocorrole complexes of third row transition metals (see Formula I below) may be used as therapeutic agents, catalysts, components of oxygen detectors, and components of light emitting diodes. In particular, metallocorrole complexes of third row transition metals may be used as improved photosenitizers in photodynamic therapy; as improved catalysts in aziridination, epoxidation, and water splitting reactions; as improved in vivo imaging agents; and as improved components in the emissive layer of OLEDs. Due to their strongly sigma-donating nature, corroles are able to stabilize third row transition metals in high oxidation states. Third row transition metals are significantly more electropositive than their first and second row counterparts and may therefore act as improved catalysts. In addition, the high spin-orbit coupling constants of third row transition metals may lead to easier singlet-triplet inter-system crossing in the excited state, which in turn may allow for long-wavelength phosphorescence that is desirable for many applications.
US08680265B2 Process for the preparation of a boron-substituted porphyrin
Processes are disclosed for the preparation of a compound having the formula: (I) and intermediate compounds wherein M is a single-photon-emission tomography imageable radiometal and/or a paramagnetic metal, R is hydrogen or a halogen provided that at least one R is halogen and Y is selected from ortho, meta or para O(CH2)nC2HB9H10 or O(CH2)nC2HB10H10 wherein n is 0 or an integer from 1 to 20 and O(CH2)nC2HB9H10 is nido ortho-, meta- or para-carborane and O(CH2)nC2HB10H10 is ortho-, meta- or para-carborane.
US08680261B2 Methods for purifying nucleic acids
Methods are provided for producing highly purified compositions of nucleic acids by using a highly streamlined and readily automated process. The methods use static mixers for lysing cells and precipitating debris, following by centrifugation and ion exchange chromatography. The process may include a purification step using tangential flow ultrafiltration. A scaleable process for producing pharmaceutical grade plasmid DNA, useful for gene therapy, is provided.
US08680260B2 18F-labeled azide compound, reagent for 18F-labeling and method for 18F-labeling of alkyne compound using same
The present invention provides an 18F-labeled azide compound usable in the Huisgen reaction which enables 18F-labeling although only a small quantity of alkyne compound is available as a counterpart substrate, more specifically the 18F-labeled azide compound enabling the PET to be applied to peptides or oligonucleotides and enabling the 18F-labeling of any sites of oligonucleotide other than the 5′ end or 3′ end thereof, a reagent for 18F-labeling, and a method for 18F-labeling of an alkyne compound using the same.
US08680257B2 Kits for comparative transcript analysis and mutant sequence enrichment
A kit to execute a method of simultaneously performing comparative transcript analysis in a multitude of samples. The kit includes a blocking adapter. The blocking adapter includes an inert 3′ end.
US08680249B2 Leafthopper ecdysone receptor nucleic acids, polypeptides, and uses thereof
The present invention relates to a novel isolated leafhopper ecdysone receptor polypeptide. The invention also relates to an isolated nucleic acid encoding the leafhopper ecdysone receptor polypeptide, to vectors comprising them and to their uses, in particular in methods for modulating gene expression in an ecdysone receptor-based gene expression modulation system and methods for identifying molecules that modulate leafhopper ecdysone receptor activity.
US08680247B2 Monoclonal antibodies against glypican-3
The present disclosure provides isolated monoclonal antibodies, particularly human monoclonal antibodies that specifically bind to Glypican-3 with high affinity. Nucleic acid molecules encoding Glypican-3 antibodies, expression vectors, host cells and methods for expressing the Glypican-3 antibodies are also provided. Immunoconjugates, bispecific molecules and pharmaceutical compositions comprising the Glypican-3 antibodies are also provided. Methods for detecting Glypican-3, as well as methods for treating various Glypican-3-related conditions, including hepatocellular cancer, are disclosed.
US08680244B2 Method for the production of antibodies that bind to multiple membrane spanning proteins
Enveloped virus vectors are described which comprise a cellular virus receptor protein and which are capable of fusing with a cell which comprises a viral envelope protein to which the cellular virus receptor protein is cognate. Enveloped virus vectors comprising a plurality of cellular virus receptor proteins are also described. Methods for making the enveloped virus vectors are described, as are methods of using the enveloped virus vectors. The invention further relates to a lipoparticle comprising a membrane spanning protein, and the lipoparticle can be attached to a sensor surface. The invention relates to methods of producing and using the lipoparticle to, inter alia, assess protein binding interactions.
US08680239B2 Use of RGM and its modulators
The present invention relates to the use of a modulator of a polypeptide having or comprising an amino acid sequence as disclosed herein or of a functional fragment or derivative thereof or of a polynucleotide encoding said polypeptide or fragment or derivative for the preparation of a pharmaceutical composition for preventing, alleviating or treating diseases or conditions associated with the degeneration or injury of vertebrate nervous tissue, associated with seizures or associated with angiogenic disorders or disorders of the cardio-vascular system.
US08680238B2 Monomeric variants of the tetrameric eqFP611
Monomeric eqFP611 variants exhibit red fluorescent properties and DNA encoding monomeric eqFP611 variants.
US08680236B2 Altered OspA of borrelia burgdorferi
Provided herein are OspA polypeptides from Lyme Disease-causing Borrelia having certain alteration(s). In one embodiment, the alteration(s) increase the conformational stability of the OspA polypeptide containing the alteration(s) while maintaining at least some of the antigenicity of the corresponding unaltered OspA polypeptide. In another embodiment, the altered OspA polypeptide has reduced cross-reactivity to hLFA-1, as compared to the corresponding unaltered OspA polypeptide.
US08680226B1 Method for alcoholysis of acrylonitrile-butadiene-styrene-containing polycarbonate compositions
The disclosure provides a method for recovering a dihydroxy aromatic compound and a dialkyl carbonate from a polycarbonate-containing composition comprising a polycarbonate and acrylonitrile-butadiene-styrene. The method comprises heating the composition in the presence of an alcohol and a transesterification catalyst at a temperature of 70° C. to 200° C. and a pressure of 50 mbar to 40 bar in a reactor for a time sufficient to depolymerize the polycarbonate producing a dihydroxy aromatic compound and a dialkyl carbonate; removing the dihydroxy aromatic compound and the dialkyl carbonate from the reactor, the acrylonitrile-butadiene-styrene remaining as a coating on the surfaces of the reactor; adding a solvent to the reactor; and heating the solvent to remove the acrylonitrile-butadiene-styrene from the surfaces of the reactor.
US08680218B1 Methods for controlling dual catalyst olefin polymerizations with an organozinc compound
Methods for controlling properties of an olefin polymer using an organozinc compound are disclosed. The HLMI/MI shear ratio of the polymer can be decreased and the Mz/Mw ratio of the polymer can be increased via the addition of the organozinc compound.
US08680210B2 Method for making functionalized polymer
A macromolecule includes at least one polymer chain and terminal functionality. The terminal functionality includes a ring-opened radical of a cyclosilazane or cyclic hydrosiloxane. The polymer can include unsaturated mer units and can be provided via anionic polymerization techniques. The macromolecule can be used as a component of a composition that also includes particulate fillers, with the composition being useful for the production of vulcanizates.
US08680209B2 Stabilized fluoropolymer and method for producing same
The present invention provides a method for producing a stabilized fluoropolymer which comprises producing the stabilized fluoropolymer by subjecting a treatment target substance containing a sulfonic-acid-derived-group-containing fluoropolymer to a fluorination treatment, wherein the sulfonic-acid-derived-group-containing fluoropolymer is a fluoropolymer containing —SO3M (in which M represents H, NR1R2R3R4 or M11/L; R1, R2, R3 and R4 are the same or different and each represents H or an alkyl group containing 1 to 4 carbon atoms; and M1 represents an L-valent metal), and the treatment target substance has a moisture content of not higher than 500 ppm by mass.
US08680205B2 Flow additive for urethane system
A method for improving flow of a two-component urethane system by adding a hydroxy-functional acrylic polymer.
US08680204B2 Crosslinked ionomer compositions
The present invention relates to golf balls comprising a crosslinked ionomer composition formed by the reaction of either one or more ionomers, or an ionomer precursor composition, with one or more crosslinking agents including polyisocyanates, blocked polyisocyanates, polyurethane prepolymers, blocked polyurethane prepolymers, polyurea prepolymers, blocked polyurea prepolymers, polyamines, blocked polyamines and dicyanodiamides. The resulting modified ionomer compositions exhibit increased tensile strength and a decrease in tensile elongation as compared to the uncrosslinked ionomer analogs while maintaining Shore D hardness.
US08680197B2 Use of a polyethylene-based film in a photovoltaic module
The invention relates to the use in a photovoltaic module of a film of a composition as a backsheet or as an encapsulant, this composition comprising, with respect to the total weight of the composition: from 1 to 99% of a polyethylene having an ethylene whose level by weight is greater than or equal to 80% chosen from the homopolymers of ethylene and the copolymers of ethylene and another alpha-olefin; from 99 to 1% of a polyolefin B, other than A, carrying a reactive functional group X chosen from the anhydride carboxylic acids and epoxides. The invention also relates to, the composition additionally comprises a polyolefin C, other than B, which carries a functional group Y capable of reacting with the functional group X. The invention further relates to a photovoltaic module comprising the film which is used of the composition and also a process for the manufacture of this module.
US08680196B2 Halogen-free and phosphorus-free resin formulation and composite materials prepared therefrom
A halogen-free and phosphorus-free resin formulation, prepared by the following method, is provided. The method includes mixing a carboxy anhydride derivative, diisocyanate, a styrene maleic anhydride (SMA) copolymer derivative and a solvent to form a mixture, and heating the mixture to form a resin formulation. The disclosure also provides a halogen-free and phosphorus-free composite material with a low dielectric constant and flame resistance prepared from the resin formulation.
US08680194B2 Long-fiber-reinforced resin composition and molded article thereof
A long-fiber-reinforced resin composition including (A) a long-fiber-reinforced thermoplastic resin pellet including a thermoplastic resin, a modified polyolefin-based resin modified with an unsaturated carboxylic acid or its derivative and reinforcing fiber and satisfying (A-1) the melt index of the thermoplastic resin is 100-250 g/10 min, (A-2) the relaxation time λ of the thermoplastic resin is 0.1 (sec) or less, (A-3) the content of the reinforcing fiber is 40-70 wt %, and (A-4) the content of the modified polyolefin-based resin is 1-5 wt %; and (B) a polyolefin-based resin satisfying (B-1) the melt index of the polyolefin-based resin is 20-70 g/10 min, and (B-2) the relaxation time λ of the polyolefin-based resin is 0.23 (sec) or less; wherein the content of reinforcing fiber contained in (A) is 20-60 wt % relative to the total amount of the fiber-reinforced resin composition.
US08680189B2 Binder resin, vehicle composition, and paste composition having inorganic microparticle dispersed therein
It is an object of the present invention to provide a binder resin which, when used in an inorganic fine particle-dispersed paste composition, leaves little amount of residual carbon after sintering and can be degreased even under low temperature conditions. It is also an object of the present invention to provide a vehicle composition and an inorganic fine particle-dispersed paste composition, which are obtained by using the binder resin.The binder resin of the present invention is for use in an inorganic fine particle-dispersed paste composition containing inorganic fine particles. The binder resin contains from 5 to 55% by weight of a segment derived from methyl methacrylate, from 30 to 80% by weight of a segment derived from isobutyl methacrylate, and from 5 to 20% by weight of a segment derived from polyoxyalkylene ether monomethacrylate.
US08680188B2 Pigment disperser and easily dispersed solid pigment preparations
The invention relates to reaction products of amines with polymers containing dicarboxylic acids anhydride groups, method for the production thereof and use thereof as a dispersing additive for pigments. The invention also relates to solid pigment preparations containing said reaction products.
US08680186B2 Semi-crystalline polyolefin composition, method of producing the same, and articles made therefrom
A semi-crystalline polyolefin composition comprising: a thermoplastic crystallizable polyolefin; and one or more di-alkyl bis-oxalamide compounds having the formula: wherein R1 is a spacer group and each R2 is a peripheral group and wherein each of R1 and R2a and R2b is an independently selected hydrocarbyl group is provided. Also provided are a method for producing the semi-crystalline polyolefin composition and articles made therefrom.
US08680184B2 Curable composition and cured product thereof
The present invention provides a curable composition mainly comprising an organic polymer containing a reactive silyl group, which is free from toxic organotin catalysts so as to be environmentally friendly and maintains good surface properties after being cured. The curable composition of the present invention comprises: (A) an organic polymer having a silyl group cross-linkable by siloxane bond formation; (B) a carboxylic acid and/or a carboxylate metal salt; (C) an amine compound; and (D) a phosphorus compound having an aryl group and a melting point of 23° C. or higher.
US08680180B2 Process for producing modified epoxy resin
An epoxy resin composition comprises an epoxy resin (A) and rubber-like polymer particles (B). The rubber-like polymer particles (B) maintain a finely dispersed state of primary particles. The content of the rubber-like polymer particles (B) is 0.5 to 80% by weight when the total amount of the epoxy resin (A) and rubber-like polymer particles (B) is 100% by weight. Rubber-like polymer particles (B) are obtainable by graft-polymerizing 5 to 50% by weight of a shell layer (B-2) with 50 to 95% by weight of a rubber particle core (B-1), and average particle diameter of the rubber-like polymer particles (B) is 0.03 to 2 μm. Rubber particle core (B-1) comprises elastic material of not less than 50% by weight of at least one monomer selected from diene monomers and (meth)acrylate monomers and less than 50% by weight of another coploymerizable vinyl monomer, or polysiloxane rubber elastic materials, or a mixture thereof.
US08680174B2 Water-based ink for ink-jet printing
The present invention is directed to a water dispersion for ink-jet printing which realizes sufficient optical density and exhibits excellent filterability and storage stability; a water-based ink containing the water dispersion; and a process for producing the water dispersion or the water-based ink. The invention includes the following: (1) a water dispersion for ink-jet printing containing anionic colorant particles and cationic polymer particles, and a water-based ink for ink-jet printing containing the water dispersion; (2) a process for producing a water dispersion for ink-jet printing including a step of mixing a water dispersion of anionic colorant particles with a water dispersion of cationic polymer particles, to thereby produce a water dispersion of composite particles formed of the cationic polymer particles and the anionic colorant particles adhering thereto, and a water dispersion produced through the production process; and (3) a process for producing a water-based ink for ink-jet printing including step (A) of mixing a water dispersion of cationic polymer particles with a water-soluble organic solvent, or dispersing a cationic polymer in water and a water-soluble organic solvent, to thereby produce a dispersion containing the cationic polymer particles, water, and the water-soluble organic solvent; and step (B) of mixing the produced dispersion with a dispersion containing anionic colorant particles and water.
US08680169B2 Porous polypropylene film
Provided is a porous polypropylene film having both air permeability properties and puncture strength. A porous polypropylene film which has an air permeability of 700 seconds/100 ml or less and a puncture strength of 1.5 N or greater, and has β activity can be obtained when the porous polypropylene film is made to have a tensile strength in the machine direction of the film, EMD, of 100 MPa or greater, a tensile strength in the transverse direction to the machine direction, ETD, of less than 100 MPa, and a ratio of EMD and ETD, EMD/ETD, of 1.5 to 10.
US08680164B2 Method for recovering a boron adsorbent
The present embodiment relates to a method for recovering a boron adsorbent, including: preparing water having an electric resistivity of 0.01 MΩ·cm or more and kept at a temperature within a temperature range; and contacting the water with the boron adsorbent to release boron adsorbed at the boron adsorbent.
US08680162B2 Catalysts
A process for regenerating a spent particulate wax-containing cobalt-based Fischer-Tropsch synthesis catalyst is provided. The process includes subjecting the spent wax-containing catalyst sequentially to a dewaxing treatment, an oxidation treatment and a reduction treatment. During the dewaxing treatment, the spent wax-containing catalyst is at least partially dewaxed, with dewaxed catalyst particles being produced. During the oxidation treatment, an oxygen-containing gas is passed through a bed of the dewaxed catalyst particles at an operating temperature T° C. where 150
US08680160B2 Topical skin barrier
A topical skin barrier for protecting and promoting healing of skin, and for providing comfort to a patient, comprises a semi-solid hydrocarbon and a water-absorbing compound. The topical skin barrier effectively adheres to skin, affords protection from moisture and waste, and provides transparency in use. Methods of in vitro evaluation are for (i) a composition's protection from moisture and waste, and (ii) a composition's adhesion to skin.
US08680156B2 Soluble pharmaceutical formulations of N,N′-diaminodiphenyl sulfone for optimal use in the treatment of various diseases
The present invention aims to demonstrate that a soluble pharmaceutical formulation can be prepared of N,N′-Diamino-diphenyl sulfone which is useful in the development of an ideal drug for use against cerebral infarction, epilepsy, traumatic spinal cord injury, cranio-encephalic trauma, leprosy, Pneumocystis carinii infections and any condition which requires rapid and complete absorption of the compound. As a representative example of this application, the dissolution of N,N′-Diamino-diphenyl sulfone was evaluated as a neuroprotector in a model of acute cerebral infarction in rats. In this study, N,N′-Diamino-diphenyl sulfone showed significant prevention of brain damage, without presenting adverse effects in animals. It is also shown that the soluble pharmaceutical formulations prepared in this manner produce peak blood levels 30 minutes from oral administration and immediately via the intravenous route.
US08680155B2 Synthesis and antitumor activity of novel bis(benzylidene-benzenamine)disulfides
Novel synthetic bis(benzylidene-benzenamine)disulfides and the preparation method are disclosed in the present invention. These compounds are afforded with the oxidizing reagent at low temperature and short time period via intra-molecular coupling reaction. In vitro experiments have been revealed that bis-disulfides are cytotoxic to cancer cells, especially human breast cancer cells MCF-7. Additionally, bis-disulfides arrest the cell cycle at sub-G1 phase and increase p38 phosphorylation to result in apoptosis. Bis-disulfides also inhibit growth of murine melanoma B16 cells but have no cytotoxicity to human fibroblasts. Bis-disulfides also can reduce murine melanoma size in the mouse model. The prepared compounds of the invention would be applicable in anticancer and anti-tumor therapies.
US08680151B2 Compounds, compositions and methods for treating or preventing hypoxic or ischemic injury
Compositions and methods of treating or preventing disease or injury to a human patient or biological material undergoing ischemic or hypoxic conditions.
US08680150B2 Small molecule hematopoietic growth factor mimetic compounds that activate hematopoietic growth factor receptors
The present embodiments relate to compounds with physiological effects, such as the activation of hematopoietic growth factor receptors. The present embodiments also relate to use of the compounds to treat a variety of conditions, diseases and ailments such as hematopoietic conditions and disorders.
US08680149B2 1-amino-alkylcyclohexane derivatives for the treatment of mast cell mediated diseases
The present invention relates to the treatment of an individual afflicted with mast cell mediated diseases comprising administering to the individual an effective amount of a 1-amino-alkylcyclohexane derivative.
US08680145B1 Compositions and methods for treatment of fear of medical procedures
The invention describes methods and compositions for treating fear of medical procedures comprising administering proglumide to a patient having fear of medical procedures, followed by subjecting the patient to the fear-inducing medical procedure. Representative examples of fear of medical procedures that can be treated according to the methods and compositions described herein include: dental phobia, fear of needles, fear of surgery, and fear of childbirth.
US08680143B2 Orally active curcuminoid compounds
The invention discloses a compound of formula (I) wherein, at least one of R1, R2, R3 and R4 is —C(═O)Rn and R1, R2R3 and R4 are H or CH3 and Rn is alkyl or alkenyl group. The alkenyl group have one or more number of double bonds either in cis form or trans form or both. In Rn, where n is 12 to 30 carbons; and pharmaceutically acceptable salt thereof. The said alkenyl groups are preferably selected from the group consisting of eicosapentaenoic acid (EPA) or DHA (docosahexaenoic acid). This invention further discloses processes for their preparation of compounds of formula I and pharmaceutical compositions that contain these compounds.
US08680142B2 Ascorbate, vitamin K3 and hydroxytolans in the treatment of cancer
The combination of compounds of the hydroxytolan family with ascorbate plus naphthoquinone (Vitamin K3; VK3), or a quinone or semiquinone analogue of VK3, kill tumor cells, inhibit tumor growth and development, and treat cancer in subjects in need thereof.
US08680137B2 Agents and methods for treating ischemic and other diseases
This invention relates to methods of screening for modulators of mammalian cell injury cause by TRPM7 gene and protein activity, compounds that modulate TRPM7 gene and protein activity and methods of treatment of mammalian cell injury using modulators of TRPM7 gene and protein activity.
US08680129B2 Compounds, composition, methods, targets for cancer therapy
This invention describes methods and pharmaceutical compositions for combinational cancer treatments that are capable of inducing JNK phosphorylation and induce programmed cell death. It also identified genes as target for anti-cancer drug development and enhancement of the chemotherapeutic drug effect for the treatment of cancer. This invention points to a novel method and principle for a new avenue of developing more efficient and low or non cytotoxic cancer treatment.
US08680128B2 Synergistic antimicrobial composition of 1,2-benzisothiazolin-3-one and tris(hydroxymethyl)nitromethane
A synergistic antimicrobial composition containing 1,2-benzisothiazolin-3-one and tris(hydroxymethyl)nitromethane.
US08680127B2 Fungicide N-cycloalkyl-N-biphenylmethyl-carboxamide derivatives
The present invention relates to N-cycloalkyl-N-biphenylmethyl-carboxamide derivatives of formula (I) wherein A, Z1, Z2, Z3, X, n, Y and m represent various substituents, their process of preparation, preparation intermediate compounds, their use as fungicide active agents, particularly in the form of fungicide compositions and methods for the control of phytopathogenic fungi, notably of plants, using these compounds or compositions.
US08680119B2 Ethers, secondary amines and derivatives thereof as modulators of the 5-HT2A serotonin receptor useful for the treatment of disorders related thereto
The present invention pertains to certain compounds of Formula (Ia) and pharmaceutical compositions thereof that modulate the activity of the 5-HT2A serotonin receptor. Compounds and pharmaceutical compositions thereof are directed to methods useful in the treatment of platelet aggregation, coronary artery disease, myocardial infarction, transient ischemic attack, angina, stroke, atrial fibrillation, blood clot formation, asthma or symptoms thereof, agitation or a symptom thereof, behavioral disorders, drug induced psychosis, excitative psychosis, Gilles de la Tourette's syndrome, manic disorder, organic or NOS psychosis, psychotic disorder, psychosis, acute schizophrenia, chronic schizophrenia, NOS schizophrenia and related disorders, and sleep disorders, sleep disorders, diabetic-related disorders, progressive multifocal leukoencephalopathy and the like. The present invention also relates to the methods for the treatment of 5-HT2A serotonin receptor associated disorders in combination with other pharmaceutical agents administered separately or together.
US08680117B2 5-[(3,3,3-Trifluoro-2-hydroxy-1-arylpropyl)amino]-1H-quinolin-2-ones, a process for their production and their use as anti-inflammatory agents
The present invention relates to compounds of formula I, processes for their production and their use as anti-inflammatory agents.
US08680116B2 Quinolinone PDE2 inhibitors
The present invention is directed to quinolinone compounds which are useful as therapeutic agents for the treatment of central nervous system disorders associated with phosphodiesterase 2 (PDE2). The present invention also relates to the use of such compounds for treating neurological and psychiatric disorders, such as schizophrenia, psychosis or Huntington's disease, and those associated with striatal hypofunction or basal ganglia dysfunction.
US08680115B2 Tetrahydroquinoline analogues as muscarinic agonists
The present invention relates to tetrahydroquinoline compounds as muscarinic receptor agonists; compositions comprising the same; methods of inhibiting an activity of a muscarinic receptor with said compounds; methods of treating a disease condition associated with a muscarinic receptor using said compounds; and methods for identifying a subject suitable for treatment using said compounds.
US08680113B2 BMI-1 protein expression modulators
Compounds having Formula I: wherein the variables Ar1, Ar2, R1, R2 and R3 are defined herein, pharmaceutical compositions, and methods of using such compounds or compositions for inhibiting Bmi-1 expression.
US08680109B2 Combination product comprising SRC kinase inhibitor AZDO530 and an antioestrogen or EGFR-TK-inhibitor
The invention relates to a combination for use in the synergistic treatment of breast cancer comprising an antioestrogen and the Src kinase inhibitor AZD0530, a combination for the synergistic treatment of cancer comprising an EGFR TKI and the Src kinase inhibitor AZD0530 and a triple combination for the synergistic treatment of breast cancer comprising an antioestrogen, an EGFR TKI and the Src kinase inhibitor AZD0530.
US08680107B2 Activators and therapeutic applications thereof
The invention presents methods of identifying small molecule compounds that are activators of tumor suppressor protein p53 pathway, and its associated family members p63 and p73, function. The invention is further drawn to methods of killing tumor cells and treating cancers or other conditions requiring activation of the p53 family member pathways and DNA damage response pathways with the small molecules.
US08680106B2 Methods for treating HCV
The present invention features interferon-free therapies for the treatment of HCV. Preferably, the treatment is over a shorter duration, such as no more than 12 weeks. In one aspect, the therapies comprise administering at least two direct acting antiviral agents and ribavirin to a subject with HCV infection. For example, the therapies comprise administering to the subject effective amounts of therapeutic agent 1, therapeutic agent 2 (or therapeutic agent 3), an inhibitor of cytochrome P450 (e.g., ritonavir), and ribavirin.
US08680104B2 Piperazinylpiperidine derivatives as chemokine receptor antagonists
The present invention relates to compounds of Formula I: wherein variable substituents are defined herein, that modulate the activity of or bind to chemokine receptors such as CCR5. In some embodiments, the compounds of the invention are selective for CCR5. The compounds can be used, for example, to treat diseases associated with chemokine receptor expression or activity such as inflammatory diseases, immune diseases and viral infections.
US08680102B2 Pyrrole derivatives, their preparation and their therapeutic application
The subject of the invention is compounds of formula (I): in which R1-R10 are as defined within, the method of preparation and therapeutic application as cannabinoid CB1 receptor antagonists.
US08680098B2 Substituted aza-bicyclic imidazole derivatives useful as TRPM8 receptor modulators
The present invention is directed to substituted aza-bicyclic imidazole derivatives, pharmaceutical compositions containing them and their use in the treatment of disorders and conditions modulated by TRP M8, including for example, inflammatory pain, inflammatory hyperalgesia, inflammatory hypersensitivity condition, neuropathic pain, neuropathic cold allodynia, inflammatory somatic hyperalgesia, inflammatory visceral hyperalgesia, cardiovascular disease aggravated by cold and pulmonary disease aggravated by cold.
US08680094B2 1, 4-benzoxazine compounds and derivatives thereof as therapeutic drugs for the treatment of neurodegenerative conditions
The present invention includes compositions and methods for inhibiting kinase activity to protect against neurodegeneration including diseases such as Alzheimer's disease, Parkinson's disease, or Huntington's disease, and conditions such as ischemic stroke comprising the step of providing the subject with a therapeutically affective amount of 1,4-benzoxazine compounds and derivatives thereof.
US08680093B2 Cyclic inhibitors of 11beta-hydroxysteroid dehydrogenase 1
This invention relates to novel compounds of the Formula Ik, Im1, Im2, Im5, In1, In2, In5, lo1, lo2, lo5, Ip1, Ip3, pharmaceutically acceptable salts thereof, and pharmaceutical compositions thereof, which are useful for the therapeutic treatment of diseases associated with the modulation or inhibition of 11 β-HSD1 in mammals. The invention further relates to pharmaceutical compositions of the novel compounds and methods for their use in the reduction or control of the production of Cortisol in a cell or the inhibition of the conversion of cortisone to Cortisol in a cell.
US08680092B2 Nitrogenous heterocyclic compound and medicinal use thereof
A compound represented by formula (I): (wherein the symbols are the same as defined in the description), a salt thereof, an N-oxide thereof, a solvate thereof or a prodrug thereof, and medicinal use thereof. The compound represented by formula (I) has CXCR4 antagonistic activity. It is hence useful as, e.g., a preventive and/or therapeutic agent for CXCR4-mediated diseases such as inflammatory/immunologic diseases (e.g., rheumatoid arthritis, arthritis, retinopathy, pulmonary fibrosis, and rejection reactions of transplanted organs), allergic diseases, infections diseases (e.g., human immunodeficiency virus infection and acquired immunologic deficiency syndrome), psychoneurotic diseases, cerebral diseases, cardiac/vascular disease, metabolic diseases, cancer diseases (e.g., cancer, cancer metastasis) or as an agent for regeneration therapy.
US08680091B2 6-arylalkylamino-2,3,4,5-tetrahydro-1H-benzo[d]azepines as 5-HT2C receptor agonists
The present invention provides 6-substituted 2,3,4,5-tetrahydro-1H-benzo[d]azepines of Formula (I) as selective 5-HT2c receptor agonists for the treatment of 5-HT2c associated disorders including obesity, obsessive/compulsive disorder, depression, and anxiety, where, R6 is —NR10R11, where R10 is substituted phenylalkyl or substituted pyridylalkyl and other substituents are as defined in the specification.
US08680084B2 Oral contraceptives to prevent pregnancy and diminish premenstrual symptomatology
This invention relates to a method of preventing pregnancy and treating PMS including PMDD. More particularly, the invention relates to a method, which involves administering one of several combination oral contraceptive regimens in combination with an antidepressant and a kit containing the same.
US08680083B2 Controlled release corticosteroid compositions and methods for the treatment of otic disorders
Disclosed herein are compositions and methods for the treatment of otic disorders with steroid, NSAID, and/or adenosine triphosphatase (“ATPase”) modulator agents. In these methods, the steroidal, NSAID, and/or ATPase compositions and formulations are administered locally to an individual afflicted with an otic disorder, through direct application of these compositions and formulations onto or via perfusion into the targeted auris structure(s).
US08680082B2 Controlled release corticosteroid compositions and methods for the treatment of otic disorders
Disclosed herein are compositions and methods for the treatment of otic disorders with steroid, NSAID, and/or adenosine triphosphatase (“ATPase”) modulator agents. In these methods, the steroidal, NSAID, and/or ATPase compositions and formulations are administered locally to an individual afflicted with an otic disorder, through direct application of these compositions and formulations onto or via perfusion into the targeted auris structure(s).
US08680080B2 Natural marine source phospholipids comprising polyunsaturated fatty acids and their applications
A phospholipid extract from a marine or aquatic biomass possesses therapeutic properties. The phospholipid extract comprises a variety of phospholipids, fatty acid, metals and a novel flavonoid.
US08680078B2 Stable ophthalmic formulations
Disclosed herein are stable formulations suitable for the treatment of glaucoma and ocular hypertension.
US08680076B2 Methods of treatment, improvement and prevention using haloaryl substituted aminopurines
Provided herein are Aminopurine Compounds having the following structure: wherein R1, R2 and R3 are as defined herein, compositions comprising an effective amount of an Aminopurine Compound and methods for treating or preventing scleroderma, keloids, UV injury, or sunburn, and methods for improving or preventing scar formation.
US08680075B2 Methods and compositions for inhibiting cellular proliferation and surgical adhesion
A method for inhibiting cellular proliferation of fibroblasts and/or glioma cells in a mammal includes administering a composition to a mammal wherein the composition includes an amount of an anionic polymer and an anti-platelet agent effective to inhibit cellular proliferation of fibroblasts and gliomas in the mammal.
US08680074B2 Use of chitosans to increase nail growth rate
The present invention is directed to the use of chitosan, a chitosan derivative or a physiologically acceptable salt thereof, to increase nail growth rate. The invention is further directed to the use of chitosans to accelerate nail growth rate during treatment of nail illnesses, nail dystrophy or other nail conditions, in order to shorten considerably the specific treatments of said nail illnesses, nail dystrophy or other nail conditions.
US08680066B2 Methods for determining and inhibiting rheumatoid arthritis associated with the BRAF oncogene in a subject
The invention provides methods for determining whether a subject is suffering from a rheumatoid arthritis associated with the BRAF oncogene comprising contacting isolated fibroblasts from the subject with a molecule or pool of molecules directed to the BRAF oncogene; and culturing the sample in the presence of the agent and determining whether BRAF oncogene expression by the cell is decreased and/or whether cells in the sample return to a less transformed phenotype, exhibit decreased cell proliferation and/or exhibit increased contact inhibition, any of which is indicative that the subject is suffering from a rheumatoid arthritis associated with the BRAF oncogene.
US08680063B2 RNA interference for the treatment of gain-of-function disorders
The present invention relates to the discovery of an effective treatment for a variety of gain-of-function diseases, in particular, Huntington's disease (HD). The present invention utilizes RNA Interference technology (RNAi) against polymorphic regions in the genes encoding various gain-of-function mutant proteins resulting in an effective treatment for the gain-of-function disease.
US08680062B2 System for delivering therapeutic agents into living cells and cells nuclei
A novel class of oligomeric compounds designed for forming conjugates with biologically active substances and delivering these substances to a desired bodily target are disclosed. Novel conjugates of these oligomeric compounds and biologically active moieties, pharmaceutical compositions containing such conjugates, and uses thereof as delivery systems for delivering the biologically active substances to a desired target are further disclosed. Processes of preparing the conjugates and the oligomeric compounds and novel intermediates designed for and used in these processes are also disclosed.
US08680061B2 Medicinal forms of phospholipid preparations and methods for their preparation
A method for producing a pharmaceutical composition comprising a combination of phospholipid and glycyrrhizic acid or a pharmaceutically acceptable salt thereof, which composition is hydratable to produce an injectable medicinal form, said method comprising subjecting a mixture of phospholipid and an aqueous solution of glycyrrhizic acid or a pharmaceutically acceptable salt thereof and a carbohydrate to homogenization, for example at 800-1200 bar pressure at a temperature of less than 90° C., and subjecting the product of the homogenization to a sublimation drying step to produce said composition. Compositions obtainable using this method, and hydrated forms of these ready for administration by injection form further aspects of the invention.
US08680060B2 Compositions and methods for controlling pests with glycolipids
Biosurfactants produced by microbes are used to control pests. The biosurfactants can be produced by cultivating a biosurfactant-producing microbe, producing a fermentation broth, and obtaining the biosurfactant from the fermentation broth. Alternately, the biosurfactants can be produced in situ in the environment of the pests by applying a carbon substrate to the pests' environment, which permits naturally-occurring biosurfactant-producing microbes to grow and to generate the biosurfactants. The biosurfactants have pesticidal qualities, and can be used to control a variety of pests, while being biodegradable and otherwise avoiding adverse environmental effects that have often been associated with conventional synthetic pesticides.
US08680059B2 Oligopeptide acetate and formulations thereof
The invention relates to acetates of the tetrapeptides AQGV (SEQ ID NO:2) and LQGV (SEQ ID NO:3), pharmaceutical compositions comprising the acetates of the tetrapeptides, and methods of treating using the acetates of the tetrapeptides or pharmaceutical compositions to treat acute inflammatory conditions including sepsis.
US08680057B2 Tribonectins
The invention features a tribonectin and a method of tribosupplementation carried out by administering tribonectins directly to an injured or arthritic joint.
US08680055B2 Methods for decreasing steroidogenesis in prostate cancer cells
The present invention discloses compositions and methods for treating diseases such as cancer by targeting luteinizing hormone (LH) or its receptor (LHR) involved in androgen synthesis or testosterone production.
US08680053B2 Improving renal function with quercetin-containing compositions
This invention relates to a method of improving renal function by administering to a subject in need thereof an effective amount of a composition containing quercetin, vitamin C, vitamin B3, and folic acid.
US08680049B2 Glucagon analogues
The invention provides materials and methods for promoting weight loss or preventing weight gain, and in the treatment of diabetes, metabolic syndrome and associated disorders. In particular, the invention provides novel glucagon analogue peptides effective in such methods. The peptides may mediate their effect by having increased selectivity for the GLP-1 receptor as compared to human glucagon.
US08680047B2 Fas peptide mimetics and uses thereof
Exocyclic peptide mimetics that disable Fas were developed. A three dimensional model of the Fas receptor-ligand complex was constructed and structurally predicted regions of the receptor that were relevant to binding ligand were used to create constrained peptide mimetics. Exocyclic anti-Fas peptide mimetics were identified that block Fas receptor-ligand interactions, and modulate Fas biological activity both in vitro and in vivo. The mimetics are useful, e.g., for treating Fas-related pathologies.
US08680045B2 Compositions of a peptide targeting system for treating cancer
This invention describes a protein nanoparticle system for targeting siRNA or other drugs into tumors. The basis of the protein system is elastin-like peptides that self-assemble once exposed to the nucleic acid of the siRNA. Specific targeting peptides are fused to the core ELP structure by standard genetic engineering techniques. These targeting peptides confer specific binding of the nanoparticle to receptors on the surface of tumor cells and allow for uptake of the nanoparticle into the tumor cells.
US08680044B2 Methods and uses for inhibiting platelet coagulation
The present disclosure provides methods and uses of Slit proteins and nucleic acids for inhibiting platelet coagulation and related disorders. Further provided is a vascular device coated with Slit protein or a cell expressing a Slit protein.
US08680043B2 Synthetic immunogenic glycoconjugate for melanoma immunotherapy
The present invention refers to compounds of formula (I) as useful melanoma vaccines' active ingredients. As a matter of fact, compounds of formula (1) are immunogenic artificial antigens, mimetics of GM3 and GM3 lactone, well known tumor associated antigens (TAAs). In addition, the present invention refers to specific antibodies for compounds of formula (I) which are able to bind to the TAAs. The hereinabove reported compounds and antibodies are therefore potentially useful respectively for the active and passive immunization against tumors over-expressing GM3 ganglioside, in a preferred embodiment melanoma and colon cancer, and for their diagnosis and prognosis.
US08680042B2 Methods of treating sickle cell anemia-related conditions with MK-801 or memantine
Sickle cell anemia is a genetic disease characterized by red blood cells that assume an abnormal, rigid, sickle shape. Acute complications of Sickle cell anemia are treated symptomatically with analgesics and transfusions, and a prophylactic treatment of sickle cell crisis is long term application of hydroxyurea. According to the present invention, an N-methyl D-aspartate receptor (NMDAR) blocker is used for the treatment of sickle cell anemia and for manufacture of a medicament for the treatment of sickle cell anemia. Moreover, a method for screening for a compound effective in the treatment of sickle cell anemia comprises contacting a candidate compound with the NMDAR and selecting said candidate compound as effective if it is found to selectively reduce activity of the NMDAR.
US08680041B2 Genetic variations associated with tumors
Nucleotide and amino acid variations associated with tumors are provided. Methods for detecting variations and for diagnosing and treating tumors are provided.
US08680038B2 Copolymer containing zwitterionic units and other units, composition comprising the copolymer, and use
The present invention provides a new copolymer comprising zwitterionic units and other units, a new composition comprising the copolymer, and the use of the copolymer or the compositions for treating or modifying surfaces.
US08680035B2 Aerosol product comprising a foaming concentrate composition comprising particulate materials
An aerosol product comprises a foaming concentrate composition that comprises a surfactant and particulate material having a particle size of at least about 100 μm. The foaming concentrate composition and propellant are contained in a package comprising a container and a powder valve comprising an orifice having an orifice diameter of at least about 508 μm. Preferably, a ratio of the maximum particle size of the particulate material to the orifice diameter of the orifice is less than about 0.75.
US08680030B2 Enhanced deposit control for lubricating oils used under sustained high load conditions employing glycerine derivative with a grafted hindered phenolic and/or a hindered phenolic containing a thioether group
The present invention is directed to a lubricating oil for use in engines subjected to sustained severe load conditions, said lubricating oil comprising a base oil, and an additive package comprising one or more neutral/low TBN or a mixture of neutral/low TBN, and overbased/high TBN alkali or alkaline earth metal alkyl sulfonates, alkyl phenates, alkyl salicylates, an antioxidant selected from the group consisting of glycerine derivatives comprising glycerine grafted with a hindered phenol, hindered phenolic containing a thioether group, and mixtures thereof, optionally an additional conventional antioxidant and/or an organomolybdenum compound, and other additives, and to a method for enhancing the deposit formation resistance of a lubricating oil used in engines operated under sustained severe load comprising the addition to the lubricant of the aforesaid additive package.
US08680029B2 Lubricating oil compositions for biodiesel fueled engines
Lubricating oil used for the lubrication of engines run on biodiesel fuels are improved in their resistance to oxidation by the addition to said to lubricating oil of particular detergents, and premixed mixtures of particular detergents and anti-oxidants.
US08680023B2 Methods for screening and arraying microrganisms such as viruses using subtractive contact printing background
Methods for screening and arranging microorganisms such as viruses in an array using subtractive contact printing are provided. In one embodiment, a method for forming an array of receptors for microorganisms comprises: patterning an array of structures on a first substrate to form a template on a surface of the first substrate; applying a receptor material to a face of a second substrate; and contacting the face of the second substrate with the template to remove a portion of the receptor material from the second substrate, thereby forming an array of receptors on the second substrate.
US08680022B2 Methods and compositions
The invention relates to a complex comprising a phage particle, said phage particle comprising (i) a polypeptide; (ii) a nucleic acid encoding the polypeptide of (i); (iii) a connector compound attached to said polypeptide wherein said connector compound is attached to the polypeptide by at least three discrete covalent bonds. The invention also relates to libraries, and to methods for making complexes and to methods of screening using same.
US08680020B2 Glycan arrays on PTFE-like aluminum coated glass slides and related methods
Aluminum coated glass slides provide a novel glycan array platform. Specifically, aluminum coated glass slides increase sensitivity of fluorescent based assay methods. Additionally, aluminum coated glass slides allows for mass spectroscopic analysis of carbohydrates and provide a platform for examining activity of cellulases. The unique properties of ACG slides include: 1) the metal oxide layer on the surface can be activated for grafting organic compounds such as modified oligosaccharides; 2) the surface remains electrically conductive, and the grafted oligosaccharides can be simultaneously characterized by mass spectrometry and carbohydrate-binding assay; and 3) the slides are more sensitive than transparent glass slides in binding analysis.
US08680019B2 Universal fibronectin Type III binding-domain libraries
Walk-through mutagenesis and natural-variant combinatorial fibronectin Type III (FN3) polypeptide libraries are described, along with their method of construction and use. Also disclosed are a number of high binding affinity polypeptides selected by screening the libraries against a variety of selected antigens.
US08680015B2 Mitigating the effects of defects in high temperature semiconductor wires
A method includes locating a defect in a first segment of high temperature superconducting wire. A second segment of high temperature superconducting wire is then positioned onto the first segment of high temperature superconducting wire such that the second segment of high temperature superconducting wire overlaps the defect. A path is then created such that current flows through the second segment of high temperature superconducting wire. The first segment of high temperature superconducting wire and second segment of high temperature superconducting wire are then laminated together.
US08680014B2 Methods for improving fruit production and fruit quality
Disclosed herein are methods for improving fruit production or fruit quality in fruit trees, such as decreasing cold damage, increasing fruit size, increasing fruit quality, and/or increasing fruit set. In some embodiments, the disclosed methods include methods of decreasing cold damage to a fruit tree including applying an effective amount of a composition including DL-β-aminobutyric acid to the fruit tree, thereby decreasing cold damage, for example as compared to a control. In other embodiments, the disclosed methods include methods of increasing fruit size or fruit quality of fruit from a fruit tree, including applying an effective amount of a composition including prohexadione-calcium to the fruit tree after anthesis, thereby increasing fruit size or fruit quality, for example as compared to a control. In further embodiments, the disclosed methods include methods of increasing fruit size of fruit from a fruit tree or increasing fruit set of a fruit tree including applying an effective amount of a composition including 4-chlorophenoxyacetic acid to the fruit tree, thereby increasing fruit size or fruit set, for example as compared to a control.
US08680012B2 4-phenyl-pyrane-3,5-diones,4-phenyl-thiopyrane-3,6-diones and cyclohexanetriones as novel herbicides
Pyrandione, thiopyrandione and cyclohexanetrione compounds, which are suitable for use as herbicides.
US08680011B2 Herbicidal formulation
This invention relates to an improved granular formulation of herbicide glyphosate in form of ammonium salt using environmentally friendly adjuvants, and a process for preparation thereof. The formulation minimizes the use of some inactive ingredients without compromising the effectiveness of the product.
US08680010B2 Synergistic herbicidal composition containing penoxsulam and florasulam
A synergistic herbicidal composition containing (a) penoxsulam and (b) florasulam provides weed control in multiple crops and settings, e.g., rice, cereal and grain crops, turf, industrial vegetation management, sugar cane, range and pasture, and tree and vine orchards.
US08680007B2 Reversible thermosensitive recording medium
A reversible thermosensitive recording medium including an electronic information recording sheet having at least an electronic information recording element projecting from a surface thereof, a first sheet having a through hole into which the electronic information recording element can be inserted, and a second sheet having a cut-out portion capable of housing the entire electronic information recording sheet, wherein the second sheet houses in the cut-out portion the entire electronic information recording sheet, with being laid over the first sheet, and the electronic information recording element inserted into the through hole.
US08680006B2 Saturation of ammonia storage materials in containers
A method of saturating reversible ammonia storage materials inside a container for the purpose of achieving high volumetric ammonia storage capacity and containers filled with the materials are disclosed.
US08680003B2 Phosphinyl amidine compounds, metal complexes, catalyst systems, and their use to oligomerize or polymerize olefins
N2-phosphinyl amidine compounds, N2-phosphinyl amidinates, N2-phosphinyl amidine metal salt complexes, N2-phosphinyl amidinate metal salt complexes are described. Methods for making N2-phosphinyl amidine compounds, N2-phosphinyl amidinates, N2-phosphinyl amidine metal salt complexes, and N2-phosphinyl amidinate metal salt complexes are also disclosed. Catalyst systems utilizing the N2-phosphinyl amidine metal salt complexes and N2-phosphinyl amidinate metal salt complexes are also disclosed along with the use of the N2-phosphinyl amidine compounds, N2-phosphinyl amidinates, N2-phosphinyl amidine metal salt complexes, and N2-phosphinyl amidinate metal salt complexes for the oligomerization and/or polymerization of olefins.
US08680001B2 Preparation of supported catalyst systems containing reduced amounts of aluminoxanes
The present invention relates to a process for preparing a catalyst solid for olefin polymerization, comprising a finely divided support, an aluminoxane and a metallocene compound, which comprises: a) firstly combining the finely divided support with the aluminoxane and subsequently b) adding the reaction product of a metallocene compound with at least one organometallic compound to the modified support, catalyst solids obtainable by this process, catalyst systems comprising these catalyst solids, their use for the polymerization of olefins and a process for the polymerization of olefins.
US08679993B2 Glass composition for glass fiber, glass fiber, and glass fiber sheet
A glass composition for a glass fiber includes, in terms of oxides by mass %, 45 to 65% of SiO2, 10 to 20% of Al2O3, 13 to 25% of B2O3, 5.5 to 9% of MgO, 0 to 10% of CaO, 0 to 1% of Li2O+Na2O+K2O, SrO, and BaO.
US08679989B2 Method of manufacturing semiconductor device including removal of deposits from process chamber and supply portion
A method of manufacturing a semiconductor device has: carrying a substrate into a process chamber; depositing a thin film on the substrate by supplying inside the process chamber a first film deposition gas including at least one element among plural elements forming a thin film to be deposited and capable of accumulating a film solely and a second film deposition gas including at least another element among the plural elements and incapable of accumulating a film solely; carrying the substrate on which is deposited the thin film out from inside the process chamber; and removing a first sediment adhering to an interior of the process chamber and a second sediment adhering to an interior of the supply portion and having a chemical composition different from a chemical composition of the first sediment by supplying cleaning gases inside the process chamber and inside a supply portion that supplies the first film deposition gas while changing at least one of a supply flow rate, a concentration, and a type between a cleaning gas to be supplied inside the process chamber and a cleaning gas to be supplied inside the supply portion.
US08679983B2 Selective suppression of dry-etch rate of materials containing both silicon and nitrogen
A method of suppressing the etch rate for exposed silicon-and-nitrogen-containing material on patterned heterogeneous structures is described and includes a two stage remote plasma etch. The etch selectivity of silicon relative to silicon nitride and other silicon-and-nitrogen-containing material is increased using the method. The first stage of the remote plasma etch reacts plasma effluents with the patterned heterogeneous structures to form protective solid by-product on the silicon-and-nitrogen-containing material. The plasma effluents of the first stage are formed from a remote plasma of a combination of precursors, including nitrogen trifluoride and hydrogen (H2). The second stage of the remote plasma etch also reacts plasma effluents with the patterned heterogeneous structures to selectively remove material which lacks the protective solid by-product. The plasma effluents of the second stage are formed from a remote plasma of a fluorine-containing precursor.
US08679979B2 Using optical metrology for within wafer feed forward process control
A method of controlling the polishing of a substrate includes polishing a substrate on a first platen using a first set of parameters, obtaining first and second sequences of measured spectra from first and second regions of the substrate with an in-situ optical monitoring system, generating first and second sequences of values from the first and second sequences of measured spectra, fitting first and second linear functions to the first and second sequences of values, determining a difference between the first linear function and the second linear function, adjusting at least one parameter of a second set of parameters based on the difference, and polishing the substrate on a second platen using the adjusted parameter.
US08679971B2 Metal-contamination-free through-substrate via structure
A through-substrate via (TSV) structure that is immune to metal contamination due to a backside planarization process is provided. After forming a through-substrate via (TSV) trench, a diffusion barrier liner is conformally deposited on the sidewalls of the TSV trench. A dielectric liner is formed by depositing a dielectric material on vertical portions of the diffusion barrier liner. A metallic conductive via structure is formed by subsequently filling the TSV trench. Horizontal portions of the diffusion barrier liner are removed. The diffusion barrier liner protects the semiconductor material of the substrate during the backside planarization by blocking residual metallic material originating from the metallic conductive via structure from entering into the semiconductor material of the substrate, thereby protecting the semiconductor devices within the substrate from metallic contamination.
US08679969B2 System for self-aligned contacts
A system for forming self-aligned contacts includes electroplating a first metal contact onto a Group III-V semiconductor substrate, the first metal contact having a greater height than width and having a straight sidewall profile, etching back the semiconductor substrate down to a base layer to expose an emitter semiconductor layer under the first metal contact, conformally depositing a dielectric layer on a vertical side of the first metal contact, a vertical side of the emitter semiconductor layer and on the base layer, anisotropically etching the dielectric layer off of the semiconductor substrate to form a dielectric sidewall spacer on the vertical side of the first metal contact and providing a second metal contact immediately adjacent the dielectric sidewall spacer.
US08679968B2 Method for forming a self-aligned contact opening by a lateral etch
A self-aligned source/drain contact formation process without spacer or cap loss is described. Embodiments include providing two gate stacks, each having spacers on opposite sides, and an interlayer dielectric (ILD) over the two gate stacks and in a space therebetween, forming a vertical contact opening within the ILD between the two gate stacks, and laterally removing ILD between the two gate stacks from the vertical contact opening toward the spacers, to form a contact hole.
US08679967B2 Apparatus and methods of forming memory lines and structures using double sidewall patterning for four times half pitch relief patterning
The present invention provides apparatus, methods, and systems for fabricating memory lines and structures using double sidewall patterning for four times half pitch relief patterning. The invention includes forming features from a first template layer disposed above a substrate, forming half-pitch sidewall spacers adjacent the features, forming smaller features in a second template layer by using the half-pitch sidewall spacers as a hardmask, forming quarter-pitch sidewall spacers adjacent the smaller features, and forming conductor features from a conductor layer by using the quarter-pitch sidewall spacers as a hardmask. Numerous additional aspects are disclosed.
US08679962B2 Integrated circuit metal gate structure and method of fabrication
A method of forming a gate structure is provided. The method includes providing a metal layer in the gate structure, the metal layer includes an oxygen-gettering composition. The metal layer getters oxygen from the interface layer, which may decrease the thickness of the interface layer. The gettered oxygen converts the metal layer to a metal oxide, which may act as a gate dielectric for the gate structure. A multi-layer metal gate structure is also provided including a oxygen-gettering metal layer, an oxygen-containing metal layer, and a polysilicon interface metal layer overlying a high-k gate dielectric.
US08679961B2 Method of manufacturing semiconductor device having pre-silicide nitrogen implant
According to one embodiment, a method of manufacturing a semiconductor device which includes a MISFET, includes: forming a gate insulating film on a semiconductor substrate; forming a gate electrode on the gate insulating film; implanting nitrogen equal to or more than 5.0e14 atoms/cm2 and equal to or less than 1.5e15 atoms/cm2 in the semiconductor substrate by tilted ion implantation in a direction from an outside to an inside with respect to side surfaces of the gate electrode; depositing a metal film including nickel on areas in which nitrogen atoms are implanted, the areas are in a semiconductor substrate on both sides of the gate electrode; and performing first heat processing of reacting the metal film and the semiconductor substrate and forming metal semiconductor compound layers, the shapes of the layers are controlled by the nitrogen profiles of the areas.
US08679957B2 Method of manufacturing semiconductor device
A method of manufacturing a semiconductor device of an embodiment includes: preparing a silicon carbide substrate of a hexagonal system; implanting ions into the silicon carbide substrate; forming, by epitaxial growth, a silicon carbide film on the silicon carbide substrate into which the ions have been implanted; and forming a pn junction region in the silicon carbide film.
US08679956B2 Multiple precursor showerhead with by-pass ports
A method and apparatus that includes a processing chamber that includes a showerhead with separate inlets and channels for delivering separate processing gases into a processing volume of the chamber without mixing the gases prior to entering the processing volume is provided. The showerhead includes one or more cleaning gas conduits configured to deliver a cleaning gas directly into the processing volume of the chamber while by-passing the processing gas channels. The showerhead may include a plurality of metrology ports configured to deliver a cleaning gas directly into the processing volume of the chamber while by-passing the processing gas channels. As a result, the processing chamber components can be cleaned more efficiently and effectively than by introducing cleaning gas into the chamber only through the processing gas channels.
US08679955B2 Method for forming epitaxial wafer and method for fabricating semiconductor device
A method for forming an epitaxial wafer is provided as one enabling growth of a gallium nitride based semiconductor with good crystal quality on a gallium oxide region. In step S107, an AlN buffer layer 13 is grown. In step S108, at a time t5, a source gas G1 containing hydrogen, trimethylaluminum, and ammonia, in addition to nitrogen, is supplied into a growth reactor 10 to grow the AlN buffer layer 13 on a primary surface 11a. The AlN buffer layer 13 is so called a low-temperature buffer layer. After a start of film formation of the buffer layer 13, in step S109 supply of hydrogen (H2) is started at a time t6. At the time t6, H2, N2, TMA, and NH3 are supplied into the growth reactor 10. A supply amount of hydrogen is increased between times t6 and t7, and at the time t7 the increase of hydrogen is terminated to supply a constant amount of hydrogen. At the time t7, H2, TMA, and NH3 are supplied into the growth reactor 10.
US08679945B2 Backgrind process for integrated circuit wafers
An integrated circuit is formed by coating a top surface of a wafer that has been processed through all integrated circuit chip manufacturing steps prior to backgrind with photoresist, applying backgrind tape over a top surface of the photoresist, backgrinding a back surface of the wafer to a specified thickness, removing the backgrind tape from the top surface of the photoresist, and removing the photoresist. The surface of the integrated circuit and any devices that may be bonded to the surface of the integrated circuit are protected by the photoresist layer during removal of the backgrind tape.
US08679944B2 Progressive trimming method
The invention provides a method of trimming a structure that includes a first wafer bonded to a second wafer, with the first wafer having a chamfered edge. The method includes a first trimming step carried out over a first depth that includes at least the thickness of the first wafer and over a first width determined from the edge of the first wafer. A second trimming step is then carried out over a second depth that includes at least the thickness of the first wafer and over a second width that is less than the first width.
US08679938B2 Shallow trench isolation for device including deep trench capacitors
A method for formation of a shallow trench isolation (STI) in an active region of a device comprising trench capacitive elements, the trench capacitive elements comprising a metal plate and a high-k dielectric includes etching a STI trench in the active region of the device, wherein the STI trench is directly adjacent to at least one of the metal plate or high-k dielectric of the trench capacitive elements; and forming an oxide liner in the STI trench, wherein the oxide liner is formed selectively to the metal plate or high-k dielectric, wherein forming the oxide liner is performed at a temperature of about 600° C. or less.
US08679936B1 Manufacturing resistors with tightened resistivity distribution in semiconductor integrated circuits
An anneal recipe is provided to tighten the distribution of resistance values in the manufacture of semiconductor integrated circuits. An adjusted amount of dopant is implanted to compensate for a shift in the distribution of resistance values associated with the anneal recipe. The distribution tightening can be effectuated by including an ammonia gas flow in the anneal recipe.
US08679935B2 Methods of fabricating a semiconductor device having metallic storage nodes
The present disclosure describes methods of fabricating a semiconductor device. An exemplary method includes forming a metal pattern on a substrate and etching the metal pattern using an etchant including at least an alkaline solution and an oxidant to form a metal electrode, where at least a portion of the surface of the metal electrode is uneven.
US08679926B2 Local charge and work function engineering on MOSFET
The present disclosure provides a semiconductor device. The semiconductor device includes a semiconductor substrate having a source region and a drain region, defining a first dimension from the source to drain; and a gate stack disposed on the semiconductor substrate and partially interposed between the source region and the drain region. The gate stack includes a high k dielectric layer disposed on the semiconductor substrate; a first metal feature disposed on the high k dielectric layer, the first metal gate feature having a first work function and defining a second dimension parallel with the first dimension; and a second metal feature having a second work function different from the first work function and defining a third dimension parallel with the first dimension, the third dimension being less than the second dimension.
US08679925B2 Methods of manufacturing semiconductor devices and transistors
Methods of manufacturing semiconductor devices and transistors are disclosed. In one embodiment, a method of manufacturing a semiconductor device includes providing a workpiece comprising a plurality of fins, and forming a semiconductive material over a top surface of the plurality of fins. An etch stop layer is formed over the semiconductive material, and an insulating material is disposed over the etch stop layer. The insulating material and a portion of the etch stop layer are removed from over the plurality of fins. Forming the semiconductive material or forming the etch stop layer are controlled so that removing the portion of the etch stop layer does not remove the etch stop layer between a widest portion of the semiconductive material over the plurality of fins.
US08679922B2 Method of producing semiconductor device and method of producing solid-state image pickup device
The method includes a step of forming a mask having an opening, for forming an opening in multiple insulating films, above a semiconductor substrate on which a member becoming a first insulating film, a member becoming a second insulating film being different from the member becoming the first insulating film, a member becoming a third insulating film, and a member becoming a fourth insulating film being different from the member becoming the third insulating film are stacked in this order; a first step of continuously removing the member becoming the fourth insulating film and the member becoming the third insulating film at a portion corresponding to the opening of the mask; and a second step of removing the member becoming the second insulating film, after the first step, at a portion corresponding to the opening of the mask.
US08679919B2 Electronic device comprising a conductive structure and an insulating layer within a trench and a process of forming the same
An electronic device can include a semiconductor layer overlying a substrate and having a primary surface and a thickness, wherein a trench extends through at least approximately 50% of the thickness of semiconductor layer to a depth. The electronic device can further include a conductive structure within the trench, wherein the conductive structure extends at least approximately 50% of the depth of the trench. The electronic device can still further include a vertically-oriented doped region within the semiconductor layer adjacent to and electrically insulated from the conductive structure; and an insulating layer disposed between the vertically-oriented doped region and the conductive structure. A process of forming an electronic device can include patterning a semiconductor layer to define a trench extending through at least approximately 50% of the thickness of the semiconductor layer and forming a vertically-oriented doped region after patterning the semiconductor layer to define the trench.
US08679913B2 Method for Sr—Ti—O-based film formation
A film is formed so that the atomic numbers ratio of Sr to Ti, i.e., Sr/Ti, in the film is not less than 1.2 and not more than 3. The film is then annealed in an atmosphere containing not less than 0.001% and not more than 80% of O2 at 500° C. or above. An SrO film forming step or a TiO film forming step are repeated a plurality of times so that a sequence, in which a plurality of SrO film forming steps or/and a plurality of TiO film forming steps are performed continuously, is included. When Sr is oxidized after the adsorption of Sr, O3 and H2O are used as an oxidizing agent.
US08679911B2 Cross-coupling-based design using diffusion contact structures
An approach for providing cross-coupling-based designs using diffusion contact structures is disclosed. Embodiments include providing first and second gate structures over a substrate; providing a gate cut region across the first gate structure, the second gate structure, or a combination thereof; providing a first gate contact over the first gate structure; providing a second gate contact over the second gate structure; and providing a diffusion contact structure coupling the first gate contact to the second gate contact, the diffusion contact structure having vertices within the gate cut region.
US08679910B2 Methods of fabricating devices including source/drain region with abrupt junction profile
Provided are methods of fabricating a semiconductor device including a metal oxide semiconductor (MOS) transistor. The methods include forming a gate pattern on a semiconductor substrate. The semiconductor substrate is etched using the gate pattern as an etching mask to form a pair of active trenches spaced apart from each other in the semiconductor substrate. Epitaxial layers are formed in the active trenches, respectively. The respective epitaxial layers are formed by sequentially stacking first and second layers. The first and second layers are formed of a semiconductor layer having a lattice constant greater than the semiconductor substrate, and a composition ratio of the second layer is different from that of the first layer. Semiconductor devices having the first and second layers are also provided.
US08679907B2 Thin-film transistor array manufacturing method, thin-film transistor array, and display device
A method of manufacturing a thin-film transistor array includes: forming a gate insulating layer on gate electrodes; forming an amorphous silicon layer on the gate insulating layer; generating a crystalline silicon layer by crystallizing the amorphous silicon layer; and forming source electrodes and drain electrodes. The thicknesses of the gate insulating layer on the gate electrode is within a range in which there is a positive correlation between light absorbances of the amorphous silicon layer above the gate electrodes for the laser light and equivalent oxide thicknesses of the gate insulating layer on the gate electrodes. The thicknesses of the amorphous silicon layer above the gate electrodes is within a range in which variation of the light absorbances according to variation of the thicknesses of the amorphous silicon layer is within a predetermined range from a first standard.
US08679905B2 Metal oxide TFT with improved source/drain contacts
A method of forming ohmic source/drain contacts in a metal oxide semiconductor thin film transistor includes providing a gate, a gate dielectric, a high carrier concentration metal oxide semiconductor active layer with a band gap and spaced apart source/drain metal contacts in a thin film transistor configuration. The spaced apart source/drain metal contacts define a channel region in the active layer. An oxidizing ambient is provided adjacent the channel region and the gate and the channel region are heated in the oxidizing ambient to reduce the carrier concentration in the channel area. Alternatively or in addition each of the source/drain contacts includes a very thin layer of low work function metal positioned on the metal oxide semiconductor active layer and a barrier layer of high work function metal is positioned on the low work function metal.
US08679904B2 Method for manufacturing a thin film transistor including a channel protecting layer
A thin film transistor includes: an insulating layer; a gate electrode provided on the insulating layer; a gate insulating film provided on the gate electrode; a semiconductor layer provided on the gate insulating film, the semiconductor layer being formed of oxide; source and drain electrodes provided on the semiconductor layer; and a channel protecting layer provided between the source and drain electrodes and the semiconductor layer. The source electrode is opposed to one end of the gate electrode. The drain electrode is opposed to another end of the gate electrode. The another end is opposite to the one end. The drain electrode is apart from the source electrode. The channel protecting layer covers at least a part of a side face of a part of the semiconductor layer. The part of the semiconductor layer is not covered with the source and drain electrodes above the gate electrode.
US08679902B1 Stacked nanowire field effect transistor
A method for fabricating a nanowire field effect transistor device includes depositing a first sacrificial layer on a substrate, depositing a first layer of a semiconductor material on the first sacrificial layer, depositing a second sacrificial layer on the first layer of semiconductor material, depositing a second layer of the semiconductor material on the second sacrificial layer, pattering and removing portions of the first sacrificial layer, the first semiconductor layer, the second sacrificial layer, and the second semiconductor layer, patterning a dummy gate stack, removing the dummy gate stack, removing portions of the sacrificial layer to define a first nanowire including a portion of the first semiconductor layer and a second nanowire including a portion of the second semiconductor layer, and forming gate stacks about the first nanowire and the second nanowire.
US08679901B2 Memory cell that includes a sidewall collar for pillar isolation and methods of forming the same
A method of forming a memory cell is provided. The method includes forming a steering element pillar having a first stiffness and a sidewall, forming a sidewall collar along at least a portion of the sidewall of the steering element pillar, the sidewall collar having a second stiffness, wherein the second stiffness is greater than the first stiffness, and forming a memory element coupled to the steering element pillar. Numerous other aspects are provided.
US08679899B2 Multipath soldered thermal interface between a chip and its heat sink
A Thermal Interface Material (“TIM”) composition of matter with improved heat conductivity comprises solderable heat-conducting particles in a bondable resin matrix and at least some of the solderable heat-conducting particles comprise a solder surface. Positioning the TIM between a first surface having a solder adhesion layer and a second surface, and then heating it results in soldering some of the solderable heat-conducting particles to one another; and some to the solder-adhesion layer on the first surface as well as adhesively bonding the resin matrix to the first surface and the second surface. The first surface can comprise an electronic device, e.g., a semiconductor device and the second surface a heat sink, such as a solderable heat sink. A product comprises an article of manufacture made by the process.
US08679898B2 Semiconductor device and production method therefor
An object of the invention is to provide a method for producing a conductive member having low electrical resistance, and the conductive member is obtained using a low-cost stable conductive material composition that does not contain an adhesive. A method for producing a semiconductor device in which silver or silver oxide provided on a surface of a base and silver or silver oxide provided on a surface of a semiconductor element are bonded, includes the steps of arranging a semiconductor element on a base such that silver or silver oxide provided on a surface of the semiconductor element is in contact with silver or silver oxide provided on a surface of the base, and bonding the semiconductor element and the base by applying heat having a temperature of 200 to 900° C. to the semiconductor device and the base.
US08679895B2 Method of making thin-wafer current sensors
Embodiments relate to IC current sensors fabricated using thin-wafer manufacturing technologies. Such technologies can include processing in which dicing before grinding (DBG) is utilized, which can improve reliability and minimize stress effects. While embodiments utilize face-up mounting, face-down mounting is made possible in other embodiments by via through-contacts. IC current sensor embodiments can present many advantages while minimizing drawbacks often associated with conventional IC current sensors.
US08679894B2 Low temperature deposition of phase change memory materials
A system and method for forming a phase change memory material on a substrate, in which the substrate is contacted with precursors for a phase change memory chalcogenide alloy under conditions producing deposition of the chalcogenide alloy on the substrate, at temperature below 350° C., with the contacting being carried out via chemical vapor deposition or atomic layer deposition. Various tellurium, germanium and germanium-tellurium precursors are described, which are useful for forming GST phase change memory films on substrates.
US08679884B2 Methods for manufacturing semiconductor apparatus and CMOS image sensor
A method for manufacturing a semiconductor apparatus includes the first step of forming a silicon oxide film including a main portion on a second portion and a sub portion between a first portion and a silicon nitride film, the second step of forming a first conductivity type impurity region under the silicon oxide film, and the third step of forming a semiconductor element including a second conductivity type impurity region having an opposite conductivity to the first conductivity type impurity region in the first portion. In the second step, angled ion implantation is performed into a region under the sub portion at an implantation angle using the silicon nitride film as a mask.
US08679881B1 Growth method for reducing defect density of gallium nitride
A growth method for reducing defect density of GaN includes steps of: sequentially forming a buffer growth layer, a stress release layer and a first nanometer cover layer on a substrate, wherein the first nanometer cover layer has multiple openings interconnected with the stress release layer; growing a first island in each of the openings; growing a first buffer layer and a second nanometer cover layer on the first island; and growing a second island to form a dislocated island structure. Thus, through the first nanometer cover layer and the second nanometer cover layer, multiple dislocated island structures can be directly formed to reduce manufacturing complexity as well as increase yield rate by decreasing manufacturing environment variation. Further, the epitaxial lateral over growth (ELOG) approach also effectively enhances characteristics of GaN optoelectronic semiconductor elements.
US08679879B2 Method for fabricating quantum dot and semiconductor structure containing quantum dot
Disclosed are a method for fabricating a quantum dot. The method includes the steps of (a) preparing a compound semiconductor layer including a quantum well structure formed by sequentially stacking a first barrier layer, a well layer and a second barrier layer; (b) forming a dielectric thin film pattern including a first dielectric thin film having a thermal expansion coefficient higher than a thermal expansion coefficient of the second barrier layer and a second dielectric thin film having a thermal expansion coefficient lower than the thermal expansion coefficient of the second barrier layer on the second barrier layer; and (c) heat-treating the compound semiconductor layer formed thereon with the dielectric thin film pattern to cause an intermixing between elements of the well layer and elements of the barrier layers at a region of the compound semiconductor layer under the second dielectric thin film.
US08679876B2 Laser diode and method for fabricating same
A laser diode and method for fabricating same, wherein the laser diode generally comprises an InGaN compliance layer on a GaN n-type contact layer and an AlGaN/GaN n-type strained super lattice (SLS) on the compliance layer. An n-type GaN separate confinement heterostructure (SCH) is on said n-type SLS and an InGaN multiple quantum well (MQW) active region is on the n-type SCH. A GaN p-type SCH on the MQW active region, an AlGaN/GaN p-type SLS is on the p-type SCH, and a p-type GaN contact layer is on the p-type SLS. The compliance layer has an In percentage that reduces strain between the n-type contact layer and the n-type SLS compared to a laser diode without the compliance layer. Accordingly, the n-type SLS can be grown with an increased Al percentage to increase the index of refraction. This along with other features allows for reduced threshold current and voltage operation.
US08679874B2 Light-emitting device having a roughened surface with different topographies
This invention provides an optoelectronic semiconductor device having a rough surface and the manufacturing method thereof. The optoelectronic semiconductor device comprises a semiconductor stack having a rough surface and an electrode layer overlaying the semiconductor stack. The rough surface comprises a first region having a first topography and a second region having a second topography. The method comprises the steps of forming a semiconductor stack on a substrate, forming an electrode layer on the semiconductor stack, thermal treating the semiconductor stack, and wet etching the surface of the semiconductor stack to form a rough surface.
US08679873B2 Method for fabricating oxide-confined vertical-cavity surface-emitting laser
The present invention discloses a method for fabricating a heat-resistant, humidity-resistant oxide-confined vertical-cavity surface-emitting laser (VCSEL) by slowing down the oxidizing rate during a VCSEL oxidation process to thereby reduce stress concentration of an oxidation layer and by preventing moisture invasion using a passivation layer disposed on a laser window. The VCSEL device thus fabricated is heat-resistant, humidity-resistant, and highly reliable. In a preferred embodiment, the oxidation process takes place at an oxidizing rate of less than 0.4 μm/min, and the passivation layer is a SiON passivation layer.
US08679870B2 Method of manufacturing semiconductor element
Provided is a method of manufacturing a semiconductor element having at a cut portion with excellent quality, which minimizes a region on a silicon substrate necessary for cutting, and which prevents cutting water used when cutting by dicing is carried out from entering the semiconductor element. The method of manufacturing a semiconductor element includes: arranging, on the silicon substrate, multiple semiconductor element portions so as to be adjacent to one another; bonding the silicon substrate and a glass substrate together using the resin; and cutting the silicon substrate and the glass substrate, respectively, in a region in which the resin is provided, the cutting the silicon substrate and the glass substrate including: half-cutting the silicon substrate by dicing; cutting the glass substrate by scribing; and dividing the silicon substrate, the glass substrate, and the resin.
US08679869B2 Contact for a semiconductor light emitting device
An AlGaInP light emitting device is formed as a thin, flip chip device. The device includes a semiconductor structure comprising an AlGaInP light emitting layer disposed between an n-type region and a p-type region. N- and p-contacts electrically connected to the n- and p-type regions are both formed on the same side of the semiconductor structure. The semiconductor structure is connected to a mount via the contacts. A growth substrate is removed from the semiconductor structure and a thick transparent substrate is omitted, such that the total thickness of semiconductor layers in the device is less than 15 μm some embodiments, less than 10 μm in some embodiments. The top side of the semiconductor structure may be textured.
US08679865B2 Resin application apparatus, optical property correction apparatus and method, and method for manufacturing LED package
A resin application apparatus includes: an optical property measurement unit measuring an optical property of light emitted from a light emitting diode (LED) chip which is mounted on a package body and to which transparent resin is not applied; and a resin application unit applying light conversion material-containing transparent resin to the LED chip in accordance with a resin application amount which is decided depending on the optical property measured by the optical measurement unit.
US08679864B2 Method and system for determining semiconductor characteristics
A method for determining one or more characteristics of a partially processed integrated circuit includes a step for providing a substrate material. The method further includes a step for forming at least one opening within the substrate material. The opening can be characterized by an opening characteristic that includes a depth and a width associated with an unknown volume. The method includes a step for providing a fill material and processing the fill material to cause a first portion of the fill material to enter the opening and occupy an entirety of the unknown volume associated with the opening characteristic while a second portion of the fill material remains outside of the unknown volume. Moreover, the method includes a step for processing the second portion of the fill material using one or more processes to determine a spatial characteristic associated with the unknown volume.
US08679861B2 Semiconductor chip repair by stacking of a base semiconductor chip and a repair semiconductor chip
In one aspect, a method of enhancing semiconductor chip process variability and lifetime reliability through a three-dimensional (3D) integration applied to electronic packaging is disclosed. Also provided is an arrangement for implementing the inventive method. In another aspect, a method and on-chip controller are disclosed for enhancing semiconductor chip process variability and lifetime reliability through a three-dimensional (3D) integration applied to electronic packaging. Also provided is an on-chip reliability/variability controller arrangement for implementing the inventive method. In yet another aspect, base semiconductor chips, each comprising a plurality of chiplets, are manufactured and tested. For a base semiconductor chip having at least one non-functional chiplet, at least one repair semiconductor chiplet chiplet is vertically stacked. A functional multi-chip assembly is formed, which provides the same functionality as a base semiconductor chip in which all chiplets are functional.
US08679859B2 Method for functionalizing materials and devices comprising such materials
Devices comprising functionalized materials, and embodiments of a method for making and using such devices, are disclosed. Exemplary devices include ophthalmic devices, nanoparticles, quartz crystal microbalances, microarrays, and nanocomposites. In particular embodiments, device surfaces are modified with monomers and/or polymers, typically carbohydrate monomers and/or polymers. Embodiments of a method for making and using such devices are disclosed. Monomers and/or polymers are covalently bonded to surfaces using functionalized perhalophenylazides. In some embodiments, device surfaces are functionalized with a perhalophenylazide. One or more monomers and/or polymers subsequently are covalently bonded to the device surface using the perhalophenylazide. In other embodiments, monomers and/or polymers are derivatized with a functionalized perhalophenylazide. The derivatized monomers and/or polymers then are covalently bonded to the device surface using the perhalophenylazide. In some embodiments, graphite is functionalized with perhalophenylazide to produce a functionalized graphene sheet. In other embodiments, graphene sheets are covalently attached to functionalized substrates.
US08679857B2 Method and device for sample preparation
The invention provides pipette tip extraction columns for the purification of a DNA vector from un-clarified cell lysate containing cell debris as well as methods for making and using such columns. The columns typically include a bed of extraction media positioned in the pipette tip column, above a bottom frit and with an optional top frit.
US08679855B2 Voltage-gated metal-enhanced fluorescence, chemiluminescence or bioluminescence methods and systems
In the present invention, it is demonstrated for the first time, the influence of electrical current on the ability of surface plasmons to amplify fluorescence signatures. An applied direct current across silver island films (SiFs) of low electrical resistance perturbs the fluorescence enhancement of close-proximity fluorophores. For a given applied current, surface plasmons in “just-continuous” low resistance films are sparsely available for fluorophore dipole coupling and hence the enhanced fluorescence is gated as a function of the applied current.
US08679853B2 Biosensor with laser-sealed capillary space and method of making
A test strip or biosensor comprising a base substrate on which an electrode system is formed. One or more laminate layers overlie the base substrate to form a sample-receiving chamber in which a reagent is deposited. An opening is provided from the sample-receiving chamber to the exterior of the biosensor. The layers and the base substrate are laser welded to secure the biosensor. One of the layer and base substrate is light transmissive to allow laser welding at the interface therebetween. The biosensor may be formed from a series of continuous webs that are subsequently sliced to form individual biosensors.
US08679850B2 Methods of cationic polymer detection
The present invention concerns a method of detecting cationic polymers comprising: obtaining a target water sample containing a cationic polymer; adding a polymer dispersant solution and a phosphate solution to the target water sample, the polymer dispersant solution is comprised of a polymer dispersant with calcium and magnesium hardness and the phosphate solution is comprised of a phosphate; standing the target water sample; and measuring the turbidity of the target water sample; comparing the turbidity of said target water sample with a calibration curve of the turbidity of samples containing known concentrations of cationic polymers to determine the concentration of cationic polymers in said target water sample.
US08679849B2 Method and device for detection of heavy metal ions in water
This disclosure discloses a method and a device for the detection of heavy metal ions in water. The method includes: providing a detection material, wherein the detection material includes a hydrophilic layer which is at least partially covered by a hydrophobic layer formed from a long-chain compound selected from the group consisting of a long-chain thiol, a long-chain fatty acid and combinations thereof, and wherein a detection area is an area covered by the hydrophobic layer, and the detection area has a surface having an initial contact angle with water of more than or equal to about 120°; contacting the detection area with an aqueous solution sample; determining whether the surface of the detection area has a hydrophobicity-hydrophilicity change after contact with the aqueous solution sample; and deciding whether heavy metal ions exist in the aqueous solution sample according to the determination.
US08679848B2 Fecal sampling device and method
A collection device for use in connection with off-device testing of collected samples. The device includes a first panel having one or more apertures for receiving samples, a second panel opposite the first panel, and a removable tab having a first portion and a second portion. The first portion is aligned with at least one of apertures on the first panel and constructed such that depositing the sample through the at least one aperture causes the sample to be directly deposited on the first portion of the tab, and the second portion includes a sample-free grasping area accessible from an exterior of the device for removing the tab. A method of obtaining a sample is also disclosed.
US08679842B2 Method for increasing the pool of Ngn3+ endocrine progenitor cells and pancreatic endocrine cell mass
The present invention discloses a method for increasing the pool of Ngn3+ endocrine progenitor cells obtained from stem cells, by contacting said stem cells with a SUR1/Kir6.2 channel inhibitor. The invention also relates to a method for increasing the mass of pancreatic endocrine cells, in particular of β cells. The invention further concerns a method for treating diabetes.
US08679841B2 Allogeneic cell compositions with cross-linked CD3/CD28
A method of manipulating allogeneic cells for use in allogeneic cell therapy providing a composition of highly activated allogeneic T-cells which are infused into immunocompetent cancer patients to elicit a novel anti-tumor immune mechanism, or “Mirror Effect”. In contrast to current allogeneic cell therapy protocols where T-cells in the graft mediate the beneficial graft vs. tumor (GVT) and detrimental graft vs. host (GVH) effects, the allogeneic cells of the present invention stimulate host T-cells to mediate the “mirror” of these effects. The mirror of the GVT effect is the host vs. tumor (HVT) effect. The “mirror” of the GVH effect is the host vs. graft (HVG) effect. The anti-tumor HVT effect occurs in conjunction with a non-toxic HVG rejection effect. The highly activated allogeneic cells of the invention can be used to stimulate host immunity in a complete HLA mis-matched setting in a patient.
US08679840B2 Compositions for the preparation of mature dendritic cells
The invention relates to a method for in vitro maturation of at least one immature dendritic cell, comprising stimulating said immature dendritic cell with TNFα, IL- 1β, IFNγ, a TLR7/8 agonist and prostaglandin E2 (PG). Furthermore, the invention relates to a composition comprising these factors as well as to mature dendritic cells produced by a method of the invention.
US08679835B2 Tumor-initiating cells and methods of use
Provided herein are an isolated or enriched population of tumor initiating cells derived from normal cells, cells susceptible to neoplasia, or neoplastic cells. Methods of use of the cells for screening for anti-hyperproliferative agents, and use of the cells for animal models of hyperproliferative disorders including metastatic cancer, diagnostic methods, and therapeutic methods are provided.
US08679831B2 Processing particle-containing samples
A microfluidic device includes an input port for inputting a particle-containing liquidic samples into the device, a retention member, and a pressure actuator. The retention member is in communication with the input port and is configured to spatially separate particles of the particle-containing liquidic sample from a first portion of the liquid of the particle containing fluidic sample. The pressure actuator recombines at least some of the separated particles with a subset of the first portion of the liquid separated from the particles. The device can also include a lysing chamber that receives the particles and liquid from the retention member. The lysing chamber thermally lyses the particles to release contents thereof.
US08679830B2 Viral vectors
The present invention provides a herpes virus which lacks a functional ICP34.5 encoding gene and which comprises two or more of—(i) a gene encoding a prodrug converting enzyme; (ii) a gene encoding a protein capable of causing cell to cell fusion; and (iii) a gene encoding an immunomodulatory protein.
US08679826B2 Method for recycling paper products coated with polyester polymers
A method for recycling a paper product sized, coated, or both sized and coated with a polymer, including: pulping an aqueous wastepaper suspension including a paper product in the presence of a hydrolase, the paper product being a paper product sized and/or coated with a polyester to obtain an aqueous solution, which is a waste paper suspension including a mixture of paper fibers and the polyester, and separating the polyester from the wastepaper suspension to recycle the paper fibers of the paper product, wherein the polyester is a polyester having a melt flow rate according to EN ISO 1133 (190° C., 2.16 kg weight) of from 2 to 50 cm3/10 min, and the hydrolase includes at least one of a carboxyesterase [3.1.1.1], a lipase [3.1.1.3], and a cutinase [3.1.1.74].
US08679825B2 Method facilitating removal of bioorganic stains from surfaces
Protein-polymer composite materials are provided according to embodiments of the present invention that include an admixture of a polymer resin, a surfactant and a non-aqueous organic solvent. An aqueous solution containing bioactive proteins is mixed with the admixture. The emulsion is mixed with a crosslinker to produce a curable composition. The curable composition is cured, thereby producing the protein-polymer composite material that is useful for facilitating removal of bioorganic stains.
US08679823B2 Use of live bacteria for growth promotion in animals
The present invention relates to the use of F4+ non-pathogenic Escherichia coli strains to promote growth in an animal. The present invention also relates to the use of such strains to homogenize growth among a herd of animals. More specifically, the animal(s) of interest in the present invention are those wherein growth promotion or growth homogenization are desired goals, such as animals reared for meat production. The present invention further relates to a method for promoting growth of an animal as well as a method for homogenizing growth among a herd of animals.
US08679821B2 Bacteriophage derived methods to control lactic acid bacterial growth
Compositions and methods for protection against bacterial contamination are disclosed Antibacterial proteins and methods of use thereof are also disclosed.
US08679817B2 Variant Hypocrea jecorina CBH1 cellulase
Described herein are variants of H. jecorina CBH I, a Cel7 enzyme. The present invention provides novel cellobiohydrolases that have improved thermostability and reversibility.
US08679816B2 Cellulase variants with improved expression, activity and stability, and use thereof
The present disclosure relates to cellulase variants. In particular the present disclosure relates to cellulase variants having improved expression, activity and/or stability. Also described are nucleic acids encoding the cellulase variants, compositions comprising the cellulase variants, and methods of use thereof.
US08679815B2 Expression of granular starch hydrolyzing enzyme in Trichoderma
The present invention relates to filamentous fungal host cells and particularly Trichoderma host cells useful for the production of heterologous granular starch hydrolyzing enzymes having glucoamylase activity.
US08679809B2 Cell-matrix microspheres, methods for preparation and applications
A method has been developed to produce stable cell-matrix microspheres with up to 100% encapsulation efficiency and high cell viability, using matrix or biomaterial systems with poor shape and mechanical stability for applications including cell therapeutics via microinjection or surgical implantation, 3D culture for in vitro expansion without repeated cell splitting using enzymatic digestion or mechanical dissociation and for enhanced production of therapeutic biomolecules, and in vitro modeling for morphogenesis studies. The modified droplet generation method is simple and scalable and enables the production of cell-matrix microspheres when the matrix or biomaterial system used has low concentration, with slow phase transition, with poor shape and mechanical stability.
US08679804B2 Modified yeast strain and a method for producing squalene using the same
The present invention relates to a modified yeast strain which is prepared by introducing a vector that expresses HMG-CoA reductase (hydroxymethylglutaryl CoA reductase) and farnesyl pyrophosphate synthase, and a method for producing squalene using the same. More particularly, the present invention relates to Saccharomyces cerevisiae Y2805 modified yeast strain that is transformed with a vector including the HMG1 gene, and ispA or Erg20 gene, and a method for producing squalene with high efficiency by culturing the modified yeast strain.
US08679802B2 Methyl butenol synthase
The present invention provides novels genes encoding methyl butenol (MBO) synthase, methy butenol synthases and their use in methyl butenol production.
US08679800B2 Method for producing lactic acid from plant-derived raw material, and lactic-acid-producing bacterium
The present invention provides: a lactic acid-producing Escherichia coli comprising at least one gene of a sucrose non-PTS gene group, including at least a sucrose hydrolase gene, provided that a combination of a repressor protein (cscR), a sucrose hydrolase (cscA), a fructokinase (cscK) and a sucrose permease (cscB) and a combination of a sucrose hydrolase (cscA), a fructokinase (cscK) and a sucrose permease (cscB) are excluded, wherein the lactic acid-producing Escherichia coli comprises a lactic acid production enhancing system provided by genetic recombination; and a lactic acid production method including producing lactic acid from a plant-derived sucrose-containing raw material by using the lactic acid-producing Escherichia coli.
US08679796B2 Galactose-rich polysaccharide, process for the production of the polymer and its applications
This invention concerns a biopolymer consisting of a polysaccharide composed of galactose (50-90%), glucose (1-25%), mannose (1-25%) and rhamnose (0.5-20%), which may additionally contain, in trace amounts, xylose, fucose, ribose, arabinose and/or fructose. The galactose-rich polymer also contains non-saccharide components, namely, acyl groups. This invention also concerns a process for the production of the galactose-rich polymer, by microbial fermentation using glycerol or glycerol-rich substrates as carbon source, and recovery of the polymer from the culture broth. From the process for the production of the galactose-rich polymer results the co-production of intracellular biopolymers, namely, polyhydroxyalkanoates. This invention also concerns to the application of the galactose-rich polymer and the products of its partial or complete degradation and/or derivatization, namely, galacto-oligosaccharides, galactose, rhamnose and others, by physical, chemical and/or biological methods, in food, agricultural, textile and paper industries, pharmaceutical and cosmetic products, oil and metal recovery in mining industry, industrial waste treatment and wastewater treatment, among others.
US08679793B2 Method for producing ethanol using raw starch
The present invention is directed to methods for producing high levels of alcohol during fermentation of plant material, and to the high alcohol beer produced. The present invention is also directed to methods for producing high protein distiller's dried grain from fermentation of plant material, and to the high protein distiller's dried grain produced. The present invention also relates to reduced stack emissions from drying distillation products from the production of ethanol.
US08679792B2 Glucoamylase variants with altered properties
The present disclosure relates to variants of a parent glucoamylase having altered properties (e.g., improved thermostability and/or specific activity). In particular, the present disclosure provides compositions comprising the variant glucoamylases, including starch hydrolyzing compositions and cleaning compositions. The disclosure also relates to DNA constructs encoding the variants and methods of producing the glucoamylase variants in host cells.
US08679788B2 Methods for the detection of nucleic acid differences
The invention provides methods permitting the detection of small amounts of different nucleic acids in the presence of an excess amount of wild-type nucleic acids. Also provided herein are method so detecting infectious disease minority variants, methods of forensic identification, methods of diagnosing cancer and monitoring disease progress.
US08679787B2 Comparative transcript analysis
A method of preparing an antisense DNA probe for comparative transcript analysis. The method includes providing an antisense DNA probe. The method also includes linking a blocking adapter to the antisense DNA probe.
US08679781B2 In vitro peptide expression library
The invention provides a method for making in vitro peptide expression libraries, and for the isolation of nucleotide sequences encoding peptides of interest, wherein the peptides or proteins are specifically associated with the DNA encoding them through non-covalent protein:DNA binding. The method describes ways of making the library itself, DNA molecules encoding the library and uses of the expression library.
US08679780B2 Method of reducing immunological tolerance to malignancy
Disclosed are therapeutic formulations comprising myristoylCoA and N-myristoyl transferase and methods of using such formulations to stimulate the immune system of a mammal afflicted with carcinoma and having a detectable blood level of unacylated A-protein to produce an immune response thereto. Also disclosed are methods of treating an A-protein displaying carcinoma in a mammal.
US08679776B2 Activatable dyes
Novel, activatable dyes, such as photoactivatable dyes, e.g., oxazine dyes, are described. Some of the dyes are targeting dyes that can, e.g., target biomolecules, such as polypeptides, proteins, or nucleic acids. Upon activation, such as by irradiation, the novel dyes rapidly turn on their fluorescence and emit light, such as near-IR light with spatial and temporal precision.
US08679775B2 Infrared measurement for the rapid enumeration of microbial concentrations
A method for testing for presence of a microbe in a sample includes measuring an instantaneous transmission rate of two or more wavelengths through the sample (1403), providing predetermined transmission rates corresponding to positive or negative samples for the presence of the microbe for each of the two or more wavelengths, and determining a probability of the presence of the microbe based on the instantaneous transmission rate for each of the two or more wavelengths through the sample by comparing the instantaneous transmission rate to the predetermined transmission rates (1404).
US08679774B2 Lipolytic enzyme variants
The substrate specificity of a lipolytic enzyme can be modified by making alterations to the amino acid sequence in a defined region of the lipolytic enzyme, so as to increase the level of a desired activity or to decrease the level of an undesired activity. Thus, the inventors have developed lipolytic enzyme variants with a modified amino acid sequence with a substrate specificity which can be tailored for specific uses.
US08679770B2 Serum bactericidal assay for N. meningitidis specific antisera
The present invention relates to the field of Serum Bactericidal Activity (SBA) assays for Gram negative bacteria, in particular N. meningitidis. The SBA assay is the most important method for measuring functional activity of serum antibodies against meningococcus. In order to determine whether a subject or a population is seropositive against invasive meningococcus the SBA test should ideally be both sensitive and specific. The inventors have found the standard N. meningitidis serotype A and W SBAs can be significantly improved in this regard.
US08679769B2 Detection of endometrial secretion markers for assessment of endometriosis
The present invention refers to a group of biomarkers and to non-invasive in vitro methods for the diagnosis or prognosis of endometriosis, as well as to a kit to perform said methods.
US08679761B2 Method for detection of inflammation in the urinary tract or urethra
A method for detecting inflammation in the urinary tract or urethra of a patient, especially urethritis, comprises a) contacting leucocytes obtained from a urine sample provided by the patient with a luminescence reagent which emits light on reaction with an oxidant; b) adding an activator to the mixture of leucocytes and luminescence reagent; c) continuously monitoring and/or measuring light emitted by the luminescence reagent over a predetermined time period commencing before and ending after the addition of the activator. The light emission is indicative of the presence or absence of inflammation in the urinary tract or urethra of the patient. The urine sample is preferably a sample of first pass urine. The method makes possible a diagnosis especially of urethritis and, in particular, urethral infections selected from Chlamydia trachomatis and Neisseria gonorrhoeae, which can be carried out quickly without invasive procedures. A diagnostic kit for carrying out the method, comprising a luminescence reagent which emits light on reaction with an oxidant, an activator and a library of standard signature light emission curves is also disclosed.
US08679756B1 Compositions and methods for intramolecular nucleic acid rearrangement
Aspects of the present invention are drawn to processes for moving a region of interest in a polynucleotide from a first position to a second position with regard to a domain within the polynucleotide, also referred to as a “reflex method”. In certain embodiments, the reflex method results in moving a region of interest into functional proximity to specific domain elements present in the polynucleotide (e.g., primer sites and/or MID). Compositions, kits and systems that find use in carrying out the reflex processes described herein are also provided.
US08679753B2 Methods for making and using molecular switches involving circular permutation
The invention provides molecular switches which couple external signals to functionality, and combinatorial methods of making and using the same involving circular permutation of nucleic acid and amino acid sequences. The switches according to the invention can be used, for example, to regulate gene transcription, target drug delivery to specific cells, transport drugs intracellularly, control drug release, provide conditionally active proteins, perform metabolic engineering, and modulate cell signaling pathways. Libraries comprising the switches, expression vectors and host cells for expressing the switches are also provided.
US08679751B2 System and method for particle filtration
Embodiments of the present disclosure feature a filtration system comprising a filtration module for particle filtration and methods of using the device for the isolation of particles (e.g., viable cells). Advantageously, embodiments of the device provide for the high throughput filtration of large volumes of sample while preserving cell viability and. providing high yields.
US08679749B2 Red fluorescent proteins with enhanced bacterial expression, increased brightness and reduced aggregation
Polynucleotides encoding variant polypeptides of DsRed are provided herein. The DsRed variants have increased bacterial expression, reduced aggregation, increased solubility, shifted emission spectra or increased brightness relative to a wild-type DsRed.
US08679747B2 Compositions, devices, systems, for using a nanopore
The invention herein disclosed provides for devices and methods that can detect and control an individual polymer in a mixture is acted upon by another compound, for example, an enzyme, in a nanopore in the absence of requiring a terminating nucleotide. The devices and methods are also used to determine rapidly (˜>50 Hz) the nucleotide base sequence of a polynucleotide under feedback control or using signals generated by the interactions between the polynucleotide and the nanopore. The invention is of particular use in the fields of drug discovery, molecular biology, structural biology, cell biology, molecular switches, molecular circuits, and molecular computational devices, and the manufacture thereof.
US08679744B2 Method for cleaning and isolating nucleic acid using ammonium or phosphonium cationic detergents
The present invention relates to a method for cleaning and isolating nucleic acids using cationic detergents with the general formula (I): Y+R1R2R3R4X−  (I) where Y can represent nitrogen or phosphorus R1, R2, R3 and R4 can represent independently from one another an unbranched or branched C1-C20-alkyl residue, C3-C6-alkenyl residue, C3-C6-alkinyl residue and/or a C6-C20-aryl residue as well as a C6-C26-aralkyl residue, and X— can represent an anion of an inorganic or organic single or multi-basic acid.
US08679741B2 Methods and compositions for the extraction and amplification of nucleic acid from a sample
Provided herein are methods, compositions and kits to extract and relatively enrich by physical separation or amplification short base pair nucleic acid in the presence of a high background of genomic material (e.g., host or maternal nucleic acids).
US08679739B2 Method and apparatus for diagnostic analyses
A method for diagnostic analysis, in particular to identify pathogens, such as viruses, bacteria or other micro-organisms present in a biological sample, comprises a first step of measuring and continuously monitoring the turbidity and/or the concentration of the pathogens, by means of an instrumental reading technique, of a liquid culture medium into which the sample to be analyzed has been inoculated and in which the replication of the pathogens possibly present occurs, said measuring and monitoring being carried out dynamically during the replication of the pathogens growing in the culture medium; and a second step of identifying the pathogens, carried out by taking at least an aliquot of the liquid culture medium containing the biological sample directly obtained from the first step, which has reached a desired value of turbidity according to a standardized value scale, such as the McFarland turbidity scale, and/or of concentration of the pathogens, and using said aliquot directly in mass spectrophotometric identification means (15) in order to identify the pathogens, which means are calibrated in their functioning depending on the measurement results of the first step. The desired values of turbidity and/or of concentration of the pathogens are preliminarily selected, during the first step, on the basis of the specific needs which, on each occasion, are identified in order to carry out the second identification step.
US08679738B2 Water-soluble AIE luminogen for monitoring and retardation of amyloid fibrillation of insulin
The presently described subject matter is directed to a water-soluble conjugated polyene compound and the derivatives thereof that exhibit aggregation induced emission, as well as any water dispersible, fluorescent, polymeric microparticles, nanoparticles, and/or pharmaceutical composition comprising the water-soluble conjugated polyene compound and/or the derivatives thereof. Also provided are methods of making and using the compound, derivatives and particles of the presently described subject matter. The presently described water-soluble conjugated polyene compound are useful as bioprobes for the detection of biomacromolecules, in the manufacture of sensors, in monitoring and retarding formation of amyloid protein fibril in vitro and in vivo, and in developing anti-cancer drugs.
US08679737B2 Microfluid device and method of producing diffusively built gradients
A microfluid device for producing diffusively built gradients comprising a bottom plate and a cover plate, wherein the cover plate has recesses and is connected to the bottom plate in a liquid-tight manner so that the recesses form at least two reservoirs and one observation chamber, which connects the reservoir, a reservoir can be filled particularly through an inlet/outlet through the cover plate, and the cross-sectional surface of the observation chamber is at least 5 times, preferably at least 200 times smaller at the aperture of the observation chamber into one of the reservoirs than the maximum cross-sectional surface of the reservoir in parallel to this cross-sectional surface of the observation chamber.
US08679735B2 Methods and compositions for the cryopreservation of organs
Methods and compositions are provided for the cryopreservation of human organs and tissues. In certain embodiments, Step 1 comprises perfusion with a vitrifiable cryoprotectant solution at a temperature above −10° C. for a time insufficient for the approximate osmotic equilibration of the organ with the solution, followed by cooling the organ to below −10° C. by perfusion with said solution at a reduced temperature. In certain embodiments, Step 2 comprises increasing the concentration of cryoprotectant further at a temperature from −10 to −40° C. In certain embodiments, Step 3 comprises cooling and vitrifying the organ, rewarming it, and perfusing the organ with a vitrifiable concentration of cryoprotectant whose temperature is either raised gradually or is held at ≧−15° C. Compositions are provided that allow safe organ perfusion with vitrifiable media at >−10° C. and almost complete avoidance of chilling injury at −20 to −25° C. and that allow slow warming after vitrification without freezing.
US08679730B2 Azide functionalized poly(3-hexylthiophene) and method of forming same
The invention relates azide functionalized poly(3-hexylthiophene)s. Various azide functionalized poly(3-hexylthiophene)s and intermediates are disclosed and described, as well as method for making novel monomers that are synthesized and transformed into P3HT-Nmp for use as organic conducting polymers in organic photovoltaic devices.
US08679729B2 Method for forming patterns of semiconductor device by using mixed assist feature system
Disclosed is a method for forming patterns of a semiconductor device, which includes: arranging dense patterns to be transferred in a dense pattern region of a wafer; inserting a first dummy pattern for restricting pattern distortion of the dense patterns in an outside of the array of the dense patterns; inserting a first assist feature for restricting pattern distortion of the first dummy pattern in an inside of the first dummy pattern; inserting an array of second assist features for additionally restricting pattern distortion of the first dummy pattern in an outside of the first dummy pattern, thereto designing a pattern layout to be transferred onto the wafer; and forming an array of the dense patterns and the first dummy patterns by transferring the pattern layout onto the wafer through an exposure.
US08679728B2 Method for fabricating patterned layer
A method for fabricating a patterned layer is disclosed. Firstly, a semiconductor substrate is provided. Then, a precursory gas on the semiconductor substrate is formed. Finally, a patterned layer on the semiconductor substrate is deposited by reacting the precursory gas with at least one electron beam or at least one ion beam. The present invention not only fabricates a patterned layer on the substrate in a single step but also achieves a high lithographic resolution and avoids remains of contaminations by using the properties of the electron beam or the ion beam and the precursory gas.
US08679726B2 Negative-working lithographic printing plate precursors
Negative-working lithographic printing plate precursor a negative-working imagable layer and an outermost water-soluble overcoat layer that is disposed directly on the negative-working imagable layer. The outermost water-soluble overcoat layer comprises: (1) one or more film-forming water-soluble polymeric binders, and (2) organic wax particles dispersed therein. The organic wax particles have an average largest dimension of at least 0.05 μm and up to and including 0.7 μm, as determined from a scanning electron micrographic of the dried outermost water-soluble overcoat layer. Useful organic wax particles include fluorinated or non-fluorinated hydrocarbon wax particles.
US08679723B2 Method of manufacturing toner
A method of manufacturing toner is provided. The method includes preparing a toner constituents liquid by dissolving or dispersing toner constituents in an organic solvent. The toner constituents includes a binder resin and a charge controlling agent. The charge controlling agent includes a polycondensation product of a phenol with an aldehyde. The method further includes forming a liquid column resonance standing wave in the toner constituents liquid in a chamber having at least one nozzle by vibrating the toner constituents liquid. The method further includes forming the toner constituents liquid into liquid droplets by discharging the toner constituents liquid from the nozzle. The nozzle is disposed within an area including antinodes of the liquid column resonance standing wave. The method further includes removing the organic solvent from the liquid droplets to solidify the liquid droplets.
US08679717B2 Binder resin for toner, toner and method for producing the same
A binder resin for a toner containing a vinyl resin (A), a non-crystalline polyester resin (SN) and a saturated crystalline polyester resin (SC), in which the content of the vinyl resin (A) is equal to or more than 65 mass % and equal to or less than 95 mass %, based on the total content of 100 mass % of (A), (SN) and (SC), (A) is composed of a carboxyl group-containing vinyl resin (C), a glycidyl group-containing vinyl resin (E) and a reaction product of the vinyl resins, the ester group concentration of (SC) is equal to or more than 10.0 mmol/g and equal to or less than 13.5 mmol/g, (SN) is dispersed in an island form in (A) and (SC) is contained in the island phase of (SN), and the metal component (M) containing at least one kind selected from the group consisting of Zn, Ca, Mg, Al and Ba (excluding metal oxide) is contained at least in (SC).
US08679714B2 Toner, developer, and image forming method
A toner including: a first binder resin; a colorant; a releasing agent; and a crystalline organic compound, wherein the first binder resin contains an amorphous polyester resin (a) having a polyhydroxycarboxylic acid skeleton derived from optically active monomers in a part of a main chain of the amorphous polyester resin, and the polyhydroxycarboxylic acid skeleton has an optical purity X, calculated on the monomer basis, of 80% or less, and the optical purity X is determined from the equation, Optical Purity X (%)=|X(L-form)−X(D-form)| wherein the crystalline organic compound is any one of a crystalline polyester resin (b) and a crystalline low molecular compound having a melting point of 60° C. to 100° C., and being selected from a group consisting of fatty acid having 16 to 24 carbon atoms, alcohol having 16 to 24 carbon atoms, a fatty acid ester compound, and aliphatic carboxylic acid amide.
US08679711B2 Electrophotographic photoreceptor
An electrophotographic photoreceptor is disclosed, comprising, on an electrically conductive substrate, a photosensitive layer and a surface layer provided sequentially in that order, in which the surface layer is a layer formed by polymerizing a polymerizable compound (I) containing seven to ten functional groups and exhibiting a reactive group equivalent of not more than 140 and not less than 100.
US08679709B2 Electrophotographic photoreceptor, process cartridge, image forming apparatus, and film forming coating solution
According to the invention, there is provided an electrophotographic photoreceptor comprising a conductive substrate and a photosensitive layer provided on a surface of the conductive substrate, an outermost layer of the photosensitive layer containing a crosslinked product composed of a guanamine compound and at least one charge transporting material having at least one substituent selected from the group consisting of —OH, —OCH3, —NH2, —SH, and —COOH.
US08679697B1 Compressible fuel cell subgasket with integrated seal
Fuel cell subgaskets made of extrusion based, microcellular polymeric foam; fuel cell stacks comprising the provided subgaskets; methods of sealing between plates of a fuel cell stack using the provided subgaskets; and methods of manufacturing such subgaskets.
US08679696B2 PEM fuel cell stack hydrogen distribution insert
A fluid distribution insert adapted to be received within an inlet header of a fuel cell assembly is disclosed. The fluid distribution insert includes a hollow insert with a first end and a second end. An inlet is formed at the first end of the hollow insert in fluid communication with a source of a reactant gas and adapted to receive the reactant gas therein. A plurality of outlets is formed intermediate the first end and the second end. A plurality of flow channels is formed in the hollow insert providing fluid communication between the inlet and the outlets to deliver the fluid to a plurality of fuel cells of the fuel cell assembly, wherein a total flow volume and flow resistance of each of the flow channels is substantially the same to provide for a substantially simultaneous delivery of the reactant gas to the fuel cells.
US08679690B2 Device and method for controlling fuel cell system having oxygen concentration transient reduction
A fuel cell system has a fuel cell generating power using a fuel gas and an oxidizing agent gas serving as materials of the system and a material supply section supplying the materials to the fuel cell. The power generated by the fuel cell is extracted to a load. A device for controlling the fuel cell system has: a material flow calculation section calculating a material flow supplied to the fuel cell so as to cause the fuel cell to generate the power of a required power generation amount; a material reduction limit detection section calculating a limit for reducing the material flow, based on a power generation state of the fuel cell; and a material flow change section controlling the material supply section so as to change the material flow calculated by the material flow calculation section to the limit calculated by the material reduction limit detection section.
US08679686B2 Non-aqueous electrolyte for a high-voltage lithium battery
The invention relates to a positive electrode/electrolyte pair for lithium batteries operating at a voltage above 4.2 V versus Li+/Li. The electrolyte of the lithium battery used in the invention includes at least a first additive chosen from optionally substituted, cyclic or acyclic, carboxylic or dicarboxylic anhydrides and carboxylic or dicarboxylic acids, and mixtures thereof, and optionally a second additive which is a lithium salt, the total content of additive(s) being greater than or equal to 0.01% by weight and less than or equal to 30% by weight, relative to the total weight of electrolyte, and the positive electrode is made of a material having a spinel structure. The lithium batteries of the invention are applicable in particular in the field of portable equipment, such as telephones, computers, camcorders, cameras and tooling.
US08679682B2 Nonaqueous-electrolyte battery and battery pack
A nonaqueous-electrolyte battery includes a positive electrode, a negative electrode which is constituted of a negative-electrode current collector and a layer containing a negative active material and deposited on one or each side of the negative-electrode current collector and in which the layer contains at least one member selected from lithium carbonate, lithium sulfide, lithium phosphide, and lithium fluoride and further contains a lithium-titanium composite oxide, and a nonaqueous electrolyte.
US08679672B2 Flat battery
Provided is a flat battery with a molded gasket extending from the opening edge of the seal can to the flat portion, where the gasket may be prevented from exfoliating from the inner surface of the seal can. A flat battery (1) includes: a negative electrode can (10) (exterior can) shaped as a cylinder with a bottom; a positive electrode can (20) (seal can) having a peripheral wall (22) (cylinder portion) and a flat portion (21), the positive electrode can being disposed as an inverted dish with respect to the negative electrode can (10); and a gasket (30) molded at least on an inner surface of the positive electrode can (20), extending from the opening edge of the peripheral wall (22) to the flat portion (21). The opening edge of the sidewall of the negative electrode can (10) is fitted onto the stepped portion (22c) of the positive electrode can (20), and a portion of the gasket (30) that is located inside the opening edge portion of the peripheral wall (22) of the positive electrode can (20) with respect to the positive electrode can has a thickness smaller than that of a portion of the gasket that is located inside the stepped portion (22c) of the positive electrode can (20) with respect to the positive electrode can.
US08679668B2 Industrial apparatus for the large-scale storage of electric energy
The invention relates to an improved industrial apparatus for the large-scale storage of energy and a process for storing and transporting electric energy by means of this apparatus.
US08679667B2 One piece compression resistant prismatic cell
A prismatic repeating frame assembly for a battery pack includes a main body and a hollow compression limiter. The main body is formed from a first polymer. The main body has an aperture formed therein. The hollow compression limiter is formed from a second polymer. The compression limiter is disposed in the aperture of the main body and permits a compression rod to be disposed therethrough. The second polymer is configured to withstand forces during an assembly of the battery pack and frequency inputs during an operation of the battery pack.
US08679656B2 Lubricant and magnetic disk
A lubricant containing a compound of the formula (I) wherein n is substantially 2, 3 or 4, R is C1-4 fluoroalkyl and Rf is —CF2O(CF2CF2O)x(CF2O)yCF2— or —CF2CF2O(CF2CF2CF2O)zCF2CF2— in which x, y and z are each 0 or a positive real number to give a number average molecular weight of 500 to 2000 to a fluoropolyether of the formula HOCH2—Rf—CH2OH including said Rf, the fluoropolyether having a molecular weight distribution (PD, weight average molecular weight/number average molecular weight) of 1.0 to 1.5.
US08679655B2 Lubricant and magnetic disk
A lubricant containing a compound (A) comprising a perfluoropolyether having a main-chain structure of the formula (1) and having a polar group at each of opposite terminals thereof, and a compound (B) comprising a perfluoropolyether having a main-chain structure of the formula (1) and having a nonpolar group at least one terminal thereof —(CF2CF2CF2O)a-  (1) wherein a is a real number of 5 to 30.
US08679648B2 Heterocyclic compound and organic light-emitting diode including the same
A heterocyclic compound represented by Formula 1 below and an organic light-emitting diode (OLED) including the same: wherein R1 through R12, Ar1, Ar2, A, B, a, and b are the same as defined above. An OLED including an organic layer including the heterocyclic compound has low driving voltage, high luminous efficiency, and a long lifetime.
US08679646B2 Organic light-emitting diode, display and illuminating device
According to one embodiment, there is provided an organic light-emitting diode including an anode and a cathode arranged apart from each other, and an emissive layer interposed between the anode and the cathode and including a host material and an emitting dopant. The emitting dopant includes a copper complex represented by the formula (1): where Cu+ represents a copper ion, the ligand A represents a pyridine derivative having nitrogen as a coordinate element and may have a substituent, PR1R2R3 is a phosphine compound coordinating with Cu+, where R1, R2 and R3 may be the same or different, and represent a linear, branched or cyclic alkyl group having 6 or less carbon atoms or an aromatic cyclic group which may have a substituent, and X− represents a counter ion (counterion) where X represents F, Cl, Br, I, BF4, PF6, CH3CO2, CF3CO2, CF3SO3 or ClO4.
US08679643B2 Plated steel sheet for cans and production method thereof
A plated steel sheet for cans with excellent secondary adhesion of an organic film and high corrosion resistance is provided, that is, a plated steel sheet for cans, which is a plated steel sheet having a alloy tin layer and a metallic tin layer in sequence from the steel sheet side, wherein a chemical conversion layer comprising tin oxide in an amount of 0.3 to 5.0 mC/cm2 in terms of electricity necessary for reduction and tin phosphate in an amount of 0.5 to 5.0 mg/m2 in terms of P is provided on the metallic tin layer and zirconium(IV) oxide in an amount of 0.2 to 5 mg/m2 in terms of Zr is provided on the chemical conversion layer. A production method thereof is also provided.
US08679642B2 System for repairing cracks in structures
A first material with a known maximum temperature of operation is coated with a second material on at least one surface of the first material. The coating has a melting temperature that is greater than the maximum temperature of operation of the first material. The coating is heated to its melting temperature until the coating flows into any cracks in the first material's surface.
US08679641B2 Wear resistant lead free alloy bushing and method of making
A bearing having improved wear resistance has a bearing material of a copper-tin-bismuth alloy which may also include phosphorus which has excellent strength, due to the solid solution of copper, tin and phosphorus (when used), attached to a steel backing shell. The material also has good lubricity as a result of the presence of the bismuth which also promotes tin mobilization and formation of a layer of tin on the bearing surface upon use of the bearing. The addition of small amounts of relatively small hard particles in the copper-tin-matrix, particularly Fe3P, MoSi2 or a mixture thereof, provides a suitable hard surface artifact to improve the wear resistance of the bearing material. The bearing includes a sintered powder compact bearing material of a copper-tin-bismuth alloy powder and a metal compound powder which is bonded to a steel backing shell, wherein the metal compound powder has an average particle size of less than 10 μm.
US08679640B2 Al alloy member, electronic device manufacturing apparatus, and method of manufacturing an anodic oxide film coated al alloy member
Provided is an Al alloy member with an excellent mechanical strength that is sufficient for use in large-scale manufacturing apparatuses. The Al alloy member is characterized in that, in mass %, Mg concentration is 5.0% or less, Ce concentration is 15% or less, Zr concentration is 0.15% or less, the balance comprises Al and unavoidable impurities, the elements of the unavoidable impurities are respectively 0.01% or less, and the Vickers hardness of the Al alloy member is greater than 30.
US08679637B2 Electrostatic film coated ophthalmic lens and method for edging same
The optical lens according to the invention comprises a temporary protective coating comprising at least one outer layer, which is mechanically alterable through friction or contact, said layer being coated with a peelable film which electrostatically adheres to the outer layer.
US08679634B2 Functional layers comprising Ni-inclusive ternary alloys and methods of making the same
Certain example embodiments relate to Ni-inclusive ternary alloy being provided as a barrier layer for protecting an IR reflecting layer comprising silver or the like. The provision of a barrier layer comprising nickel, chromium, and/or molybdenum and/or oxides thereof may improve corrosion resistance, as well as chemical and mechanical durability. In certain examples, more than one barrier layer may be used on at least one side of the layer comprising silver. In still further examples, a NixCryMoz-based layer may be used as the functional layer, rather than or in addition to as a barrier layer, in a coating.
US08679631B2 Tempered glass substrate and method of producing the same
A tempered glass substrate of the present invention is a tempered glass substrate, which has a compression stress layer on a surface thereof, and has a glass composition comprising, in terms of mass %, 40 to 71% of SiO2, 3 to 21% of Al2O3, 0 to 3.5% of Li2O, 7 to 20% of Na2O, and 0 to 15% of K2O.
US08679625B2 Solar cell sealing film and solar cell using the sealing film
The present invention is to provide a solar cell sealing film which suppresses occurrence of rust on conducting wires or electrodes and which is improved in transparency and generating efficiency of the solar cell, and a solar cell having the sealing film. The solar cell sealing film comprises ethylene-vinyl acetate copolymer, a crosslinker and an adsorbent, which comprises, as the adsorbent, an inorganic fine particle having refractive index of not more than 1.54 in an amount of 0.1 to 1.5 part by weight based on 100 parts by weight of the ethylene-vinyl acetate copolymer.
US08679617B2 Solar reflective coatings systems
Disclosed are infrared reflective coating systems. The coating compositions include an infrared transparent pigment and an infrared reflective pigment.
US08679613B2 Armor having a ballistic composite wrap slip layer and a laminate containment wrap
This invention relates to the use of an open, plain Leno Aramid fiber weave wrapped around the armor base plate in such a fashion that the wrap on the strike face surface is bonded with a thermoset resin while the continuous fibers around the back are left resin-free and able to distort, allowing localized deformation while keeping the remainder of the “wrap” holding tight. This wrap technique keeps the composite backing tight to the strike surface while allowing all of the benefits of localized fiber movement and tensile failure on the backside of the target. Other high performance fibers, such as fiberglass, also woven in a Leno weave and applied in the same method will yield similar results. This invention also relates to the placement of a “slip layer” between the fiber surface and the polymer coating of an armor system. This layer, consists of Teflon, silicone, or other low friction, bonding resistant materials, and prevents intimate bonding of the polymer coating to the fiber back and allows a low friction slip surface that isolates the polymer from the trauma of fiber deformation and breakage.
US08679611B2 Edge protection seal for bonded substrates
A dielectric material layer is deposited on exposed surfaces of a bonded structure that includes a first substrate and a second substrate. The dielectric material layer is formed on an exposed planar surface of a second substrate and the entirety of peripheral sidewalls of the first and second substrates. The dielectric material layer can be formed by chemical vapor deposition, atomic layer deposition, or plasma induced deposition. Further, the dielectric material layer seals the entire periphery of the interface between the first and second substrates. If a planar portion of the dielectric material layer can be removed by planarization to facilitate thinning of the bonded structure, the remaining portion of the dielectric material layer can form a dielectric ring.
US08679609B2 Multi-layered fuel tubing
The invention describes a flexible tubular article for transport of volatile hydrocarbons comprising: (a) an inner layer of a polyvinylidene difluoride (PVDF) polymer or a polyvinylidene difluoride copolymer; (b) an intermediate thermoplastic polyurethane (TPU) layer extruded in tubular form over the inner PVDF layer, and (c) a polyvinyl chloride polymer extruded in tubular form over the outside surface of the intermediate layer and being coextensive therewith. The tubular articles of the invention have a maximum permeation rating of 15 g/m2/day under SAE J1737 test conditions.
US08679604B2 Peelable film and package using same
The present invention is directed to a peelable packaging film comprising a first thermoplastic substrate and a second thermoplastic substrate wherein the packaging film has a Heat Shrinkage value between 0 and 10% at 102° C. in either the machine or transverse directions. The first and second substrates each have a first surface and a second surface. Each of the first surfaces comprises a polyolefin and has a surface energy of at least 36 dynes/cm. At least one first surface is oriented, preferably biaxially oriented, and at least one first surface is non-heat shrinkable. In contact with both first surfaces is a contiguous adhesive layer. A peelable interface is provided between the adhesive layer and at least one the first surfaces of the substrates. The peelable interface is adapted to have a peelable seal strength of between 60 and 2,500 grams-force/in.
US08679598B2 Vacuum insulated glass (VIG) unit including nano-composite pillars, and/or methods of making the same
Certain example embodiments of this invention relate to composite pillar arrangements for VIG units that include both harder and softer materials. The softer materials are located on the outside or extremities of the central, harder pillar material. In certain example embodiments, a high aspect ratio mineral lamellae is separated by an organic “glue” or polymer. When provided around a high strength pillar, the combination of the pillar and such a nano-composite structure may advantageously result in superior strength compared to a monolithic system, e.g., where significant wind loads, thermal stresses, and/or the like are encountered.
US08679592B2 System to continuously produce carbon fiber via microwave assisted plasma processing
A method for continuously processing carbon fiber including establishing a microwave plasma in a selected atmosphere contained in an elongated chamber having a microwave power gradient along its length defined by a lower microwave power at one end and a higher microwave power at the opposite end of the elongated chamber. The elongated chamber having an opening in each of the ends of the chamber that are adapted to allow the passage of the fiber tow while limiting incidental gas flow into or out of said chamber. A continuous fiber tow is introduced into the end of the chamber having the lower microwave power. The fiber tow is withdrawn from the opposite end of the chamber having the higher microwave power. The fiber to is subjected to progressively higher microwave energy as the fiber is being traversed through the elongated chamber.
US08679591B2 Method for reducing voids in a copper-tin interface and structure formed thereby
An embodiment is a method for forming a semiconductor assembly including cleaning a connector including copper formed on a substrate, applying cold tin to the connector, applying hot tin to the connector, and spin rinsing and drying the connector.
US08679588B2 Formulation coated self-cleaning wool
The present invention relates to methods of making articles, and systems for providing wool article have self-cleaning properties. The self-cleaning properties are brought about coating the wool articles with a photocatalyst formulation. The formulation contains titanium compounds, stabilizers, catalysts, and water.
US08679585B2 Ambient lithographic method using organoborane amine complexes
A pattern is formed and developed on a surface with an ink system comprising (i) a free radical polymerizable monomer, oligomer or polymer, (ii) an organoborane amine complex, (iii) an amine reactive compound, and (iv) oxygen. Components (i)-(iv) are distributed between an ink and a developing medium. The ink formed on the surface in a pattern is developed by exposure of the ink to the developing medium. Component (iv) may be present as naturally occurring in the air. The method has the advantage of developing polymeric and polymer composite patterns rapidly in ambient air, without heating or irradiation. The ink system can be applied to inorganic and organic surfaces, and is particularly useful for polymeric surfaces such as low energy plastics. The composition can be applied to inorganic and organic surfaces, and is particularly useful for polymeric surfaces such as low energy plastics.
US08679584B2 Method for partially coating complex components with catalytically active components
A method for partially coating a shaped body, the surface of which comprises an area to be coated and an area to be left clear, wherein with the method a protective layer is applied to the area to be left clear, a layer comprising a fluid phase is applied to the surface, and the coated shaped body is heated to a temperature at which the protective layer is removed residue-free by pyrolysis.
US08679582B2 Tunable variable emissivity materials and methods for controlling the temperature of spacecraft using tunable variable emissivity materials
Tunable variable emissivity materials, methods for fabricating tunable variable emissivity materials, and methods for controlling the temperature of a spacecraft using tunable variable emissivity materials have been provided. In an exemplary embodiment, a variable emissivity material has the formula M1(1−(x+y))M2xM3yMnO3, wherein M1 comprises lanthanum, praseodymium, scandium, yttrium, neodymium or samarium, M2 comprises an alkali earth metal, M3 comprises an alkali earth metal that is not M2, and x, y, and (x+y) are less than 1. The material has a critical temperature (Tc) in the range of about 270 to about 320K and a transition width is less than about 30K.
US08679575B2 Method of fabricating electroactive polymer transducers
Dielectric elastomer or electroactive polymer film transducers configured to minimize high electrical field gradients that can lead to partial discharge and corona.
US08679573B2 Stent coating method and apparatus
An apparatus includes a piezoelectric print head capable of ejecting a droplet of a coating substance towards a stent strut, a sensor capable of sensing a parameter of the droplet, and a controller, communicatively coupled to the print head and the sensor, capable of determining if the parameter of the droplet meets a requirement. A method includes ejecting a droplet of a coating substance towards a stent strut with a piezoelectric print head, sensing a parameter of the droplet, and determining whether the parameter of the droplet meets a requirement.
US08679572B2 Coated stent
A coated stent (20) for use in a medical procedure and methods of manufacturing the coated stent (20) are described. A stent component (30) has an expanded state in which an inner diameter (ds) of the stent (30) is less than or equal to an outer diameter (dc2) of a coating (40), thereby causing an inner surface (35) of the stent (30) to engage the outer surface (42) of the coating (40). In one exemplary method of manufacture, the stent (30) is disposed over the coating (40) when the coating (40) is provided with a first, smaller outer diameter (dc1). The coating (40) then is radially expanded to a second, larger outer diameter (dC2), which is greater than or equal to the inner diameter (ds) of the stent (30), to cause the outer surface (42) of the coating (40) to engage the inner surface (35) of the stent (30).
US08679571B2 Method for producing a bioactive surface on an endoprosthesis or on the balloon of a balloon catheter
A method for producing a bioactive surface on an endoprosthesis, or on the balloon (3) of a balloon catheter (1) is described, wherein the surface (15) of the endoprosthesis, or the surface (4) of the balloon (3) is softened. The surface (15) of the endoprosthesis, or the surface (4) of the balloon (3) is moistened with a solution (6) of an active ingredient (7), and the solvent (8) is separated from the active ingredient (7). In addition, a balloon (3) of a balloon catheter (1) is disclosed, which comprises an uncoated surface (4), wherein an unencapsulated active ingredient (7) is embedded at least partially into the material of the surface (4). Furthermore, a balloon catheter (1) is described, which comprises a balloon (3) according to the invention. In addition, an endoprosthesis, particularly a polymer stent is described, which comprises an uncoated surface (15), wherein an active ingredient (7) is embedded at least partially into the material of the surface (15).
US08679563B1 Sheeter with spiraled stripper wire and conveyer belt with landing zone
A sheeter includes an internally grooveless front roller, a rear roller configured to rotate counter to the front roller, a partially spiraled stripper wire coupled across the front roller, and a conveyer belt connected to a proximal conveyer roller and a distal conveyer roller. The conveyer belt includes a landing zone configured to prevent damage to a received product. The conveyer belt includes a raised portion adjacent to the proximal end and flat portion towards the distal end.
US08679561B2 Smokeless coffee roaster
A coffee bean roasting machine of the type having a cyclone separator heating chamber and a coffee bean roasting chamber in a recirculating process stream driven by a recirculation fan is operated to air cool the roasted coffee beans in the roasting chamber, to a temperature beneath which the beans give off smoke, while at the same time incinerating smoke removed from the roasting chamber. A purge gate in ducting between the cyclone separator and the roasting chamber is opened to allow the flow of ambient air into and through the roasting chamber while blocking flow out of the cyclone separator, so that ambient air is directed through the roasting chamber. The smoke and any airborne particulate material from the roasting chamber are carried into the heating chamber and through the incineration tube, where they are incinerated. Preferably the system and process are operated automatically by a computer and programming.
US08679550B2 Morinda citrifolia juice formulations comprising iridoids
Fortified food and dietary supplement products may be administered to produce desirable physiological improvement. In particular, embodiments of the invention relates to the administration of products enhanced with plant products and iridoids. A study was performed to evaluate the iridoid content, as well as the in vitro and in vivo bioactivities, of a beverage containing noni fruit, Cornelian cherries, and olive leaf extract. The major iridoids present were identified as asperulosidic acid, deacetylasperulosidic acid, oleuropein, morroniside, loganic acid, and loganin In the 2,2-Diphenylpicrylhydrazyl (DPPH) radical scavenging assay, remarkably high in vitro antioxidant activity was observed, with an IC50 of 3.8 μL/mL. In vivo bioactivities were evaluated in type 2 diabetic Sprague Dawley rats. In a dose-dependent manner, the composition reduced abnormal weight gain, blood glucose levels, and serum advanced glycation end products (AGEs), as well as improved immunity via increased T cell counts and CD4+/CD8+ ratios.
US08679546B2 Ruminant feed pellet composition with controlled release of physiologically active substances, and procedure for preparation and use thereof
The subject of this invention is a controlled release composition for zootechnical use. In particular, the subject of this invention is a composition comprising micro-pellets that are able to release the physiologically active substances they contain in a controlled manner. In addition, this invention refers to a procedure for preparing said composition as well as the use of said composition in the zootechnical sector.
US08679545B2 Topical corticosteroids for the treatment of inflammatory diseases of the gastrointestinal tract
Provided herein are methods for preventing or alleviating the symptoms of and inflammation associated with inflammatory diseases and conditions of the gastrointestinal tract, for example, those involving the esophagus. Also provided herein are pharmaceutical compositions useful for the methods of the present invention.
US08679542B2 Cleavage kit, and gene therapy by using the same and nucleic acid cleavage detection apparatus
A nucleic acid cleavage kit is used to cleave a target nucleic acid. The nucleic acid cleavage kit includes a carrier, an oligonucleotide, and a nucleic acid cleavage agent. The oligonucleotide recognizes at least partial sequence of the target nucleic acid. Then, the nucleic acid cleavage agent cleaves the target nucleic acid. A nucleic acid cleavage detection apparatus including the nucleic acid cleaving kit and a gene therapy by administering the nucleic acid cleavage kit are also disclosed.
US08679536B2 Aldol-crosslinked polymeric hydrogel adhesives
Adhesives formed by reacting an oxidized polysaccharide with a poly(hydroxylic) compound derivatized with acetoacetate groups in the presence of a base catalyst are disclosed. The use of the adhesives for medical and veterinary applications such as topical wound closure; and surgical procedures, such as intestinal anastomosis, vascular anastomosis, tissue repair, and ophthalmic procedures; and drug delivery are described. The adhesive may also be used for industrial and consumer applications.
US08679533B2 Pramipexole once-daily dosage form
An orally deliverable pharmaceutical composition comprises a therapeutically effective amount of pramipexole or a pharmaceutically acceptable salt thereof and at least one pharmaceutically acceptable excipient, said composition exhibiting at least one of (a) an in vitro release profile wherein on average no more than about 20% of the pramipexole is dissolved within 2 hours after placement of the composition in a standard dissolution test; and (b) an in vivo pramipexole absorption profile following single dose administration to healthy adult humans wherein the time to reach a mean of 20% absorption is greater than about 2 hours and/or the time to reach a mean of 40% absorption is greater than about 4 hours. The composition is useful for oral administration, not more than once daily, to a subject having a condition or disorder for which a dopamine receptor agonist is indicated.
US08679530B2 Liposomally encapsulated reduced glutathione, including with other pharmacologic preparation, capable of administration as an oral, topical, intraoral or transmucosal, prepartion, for reversal and prevention of oxidation of cholesterol and of low density lipoprotein
The invention proposes the sure of reduced glutathione in a liposome (liposomal reduced glutathione) for the oral administration of a therapeutically effective amount to ameliorate the progression of vascular disease, including atherosclerosis, diabetes, hypertension, narrowing of arteries leading to decreased blood flow, ischemic events, and the formation of blood clots, abnormal platelet aggregation, and thrombotic events, by reducing the amount and effect of oxidized cholesterol, oxidized HDL and oxidized LDL. The invention also proposes combining liposomal encapsulated glutathione with statin drugs to improve the effect of lowering not only cholesterol but also the oxidized cholesterol as well as oxidized HDL and oxidized LDL. The invention also proposes combining liposomal encapsulated glutathione with CoQ10 as a therapy for vascular disease and management of side effects of statin therapy.
US08679523B2 Oxygen-delivery closed cell foam matrix for wound treatment
The present invention comprises methods and compositions for delivery devices. More particularly, the present invention comprises methods and compositions for devices comprising a matrix comprising a polymer network and a non-gellable polysaccharide having oxygen and optionally active agents incorporated therein. The matrix may be formed into any desired shape for treatment of compromised tissue or for delivery of oxygen to a localized environment.
US08679520B2 Coating of stents for preventing restenosis
The invention relates to stents with at least one hemocompatible coating which contains an antiproliferative, antiinflammatory and/or antithrombotic active agent, methods for the preparation of said stents as well as the use of said stents for the prevention of restenosis.
US08679513B2 Cosmetic use of a jasmonic acid derivative for treating the hair and the scalp
The present invention relates to the cosmetic use of jasmonic acid derivatives of formula (I) in which: R1 represents a radical COOR3, R3 denoting a hydrogen atom or a C1-C4 alkyl radical, optionally substituted with one or more hydroxyl groups; R2 represents a linear saturated or unsaturated hydrocarbon-based radical containing from 1 to 18 carbon atoms, or a branched or cyclic saturated or unsaturated hydrocarbon-based radical containing from 3 to 18 carbon atoms; and also an optical isomer thereof and/or a corresponding salt thereof, in a composition for caring for and/or making up keratin fibers, in particular human keratin fibers, for the purpose of inducing and/or stimulating the growth of the keratin fibers and/or of halting their loss and/or increasing their density.
US08679512B2 Topical formulation comprising a corticosteroid as active ingredient
Topically administering a propellant-free formulation as a spray in the form of aqueous suspension of drug particles, wherein said formulation consists essentially of: micronized particles of beclometasone dipropionate (BDP) suspended in an aqueous phase, said aqueous phase comprising: an emulsifying agent selected from the class of polysorbates in an amount of 0.1 to 0.2% w/v, based on the total volume of the formulation; a sugar or a sugar alcohol in an amount of 5.0 to 5.2% w/v, based on the total volume of the formulation; a mixture of microcrystalline cellulose and carboxymethylcellulose sodium in an amount of 0.5 to 1.0% w/v, based on the total volume of the formulation; one or more preservatives; and water up to 100%, is effective for the prophylaxis and/or treatment of a dermatological disease such as atopic dermatitis, acne and psoriasis.
US08679510B2 Porin B (PorB) as a therapeutic target for prevention and treatment of infection by Chlamydia
The present invention features peptides of a PorB polypeptide, which PorB peptides are useful in production of antibodies that bind the full-length PorB polypeptide and as a therapeutic agent. In specific embodiments the invention features a composition comprising one or more PorB peptides (other than a full-length PorB polypeptide), which peptides contain at least one epitope that can elicit Chlamydia-neutralizing antibodies. The invention also features methods for induction of a protective immune response against infection by Chlamydia and Chlamydiophila.
US08679509B2 Oncolytic viruses and methods for treating neoplastic disorders
The disclosure provides mutant ribonucleotide reductase strains of poxviruses including for example vaccinia viruses. The disclosure also provides methods and for the use of these mutant ribonucleotide reductase strains of vaccinia viruses in oncolytic virotherapy.
US08679504B2 Poultry viral materials and methods related thereto
The present invention provides materials and methods for researching poultry viruses, particularly for researching infectious bronchitis viruses in poultry. Also provided are materials and methods useful for reducing the economic impact that infectious bronchitis disease has on poultry production. In one aspect of the invention, there are provided nucleic acids, amino acids and related materials and compositions useful for combating infectious bronchitis virus in poultry.
US08679493B2 Immunoglobulin Fc polypeptides
Methods and compositions involving polypeptides having an aglycosylated antibody Fc domain. In certain embodiments, polypeptides have an aglycosylated Fc domain that contains one or more substitutions compared to a native Fc domain. Additionally, some embodiments involve an Fc domain that is binds some Fc receptors but not others. For example, polypeptides are provided with an aglycosylated Fe domain that selectively binds FcγRI at a level within 2-fold of a glycosylated Fc domain, but that is significantly reduced for binding to other Fc receptors. Furthermore, methods and compositions are provided for promoting antibody-dependent cell-mediated toxicity (ADCC) using a polypeptide having a modified aglycosylated Fc domain and a second non-Fc binding domain, which can be an antigen binding region of an antibody or a non-antigen binding region. Some embodiments concern antibodies with such polypeptides, which may have the same or different non-Fc binding domain.
US08679489B2 Inhibiting cell migration
Fully human monoclonal Abs includes (i) an antigen-binding variable region that exhibits very high binding affinity for IL-1α and (ii) a constant region that is effective at both activating the complement system though C1q binding and binding to several different Fc receptors.
US08679484B2 Method for removal of toxins from mucosal membranes
The present invention provides novel mucoadhesive compounds useful in the prevention of diseases and disorders of or which are associated with the mucosal membrane.
US08679483B2 High-yield method for the production of human antibodies blocking the biological activity of a human cytokine
The invention concerns a pharmaceutical composition comprising, as the active ingredient, human natural antibodies of the IgG isotype, that neutralize the activity of a human cytokine selected from VEGF, IFNα, IL-4, TNFα and TGFβ, the said neutralizing antibodies inhibiting at least 50% of the maximum biological activity induced by an amount ranging from 0.006 ng to 0.05 ng of the said cytokine in vitro.
US08679480B2 Method to inhibit neuropathic pain by intrathecal injection of protein phosphatases
A method and corresponding pharmaceutical composition to inhibit neuropathic pain by injecting intrathecally into a mammalian subject a neuropathic pain-inhibiting amount of a phosphatase falling within E.C. 3.1.3.x, more specifically a protein phosphatase falling within E.C. 3.1.3.16, and most specifically calcineurin.
US08679474B2 Somatic stem cells
A method of treating a cellular proliferative disorder with cancer antigen-activated dendritic cells that are derived from a population of somatic stem cells. Also disclosed are methods of treating tissue damages and degenerative diseases with a population of somatic stem cells.
US08679473B2 Non-pathogenic and/or attenuated bacteria capable of inducing apoptosis in macrophages, process of manufacturing and uses thereof
The invention relates to an non-pathogenic and/or attenuated bacterium which is capable of inducing apoptosis in macrophages.
US08679472B1 Crystal of human interferon alpha 2B in complex with zinc
This application covers a novel PEGylated interferon and a novel crystalline form of interferon which are useful, inter alia, for detailed structural analysis of interferon as well as treatment and prevention of viral infections and hyperproliferative diseases such as leukemia.
US08679462B2 Methods of preventing respiratory infections
Methods for inhibiting the development of respiratory infections in humans are disclosed. One embodiment of the methods comprises pouring a predetermined amount of an oral rinse, capable of rendering ineffective a pathogen which has recently infected the respiratory tract, into the mouth of the human, agitating the oral rinse with air for a predetermined period in order to generate concentrated vapor of the oral rinse, stopping the agitating a plurality of times during which the head is tilted forward to allow the predetermined amount of an oral rinse to move away from the back of the mouth and throat, then exhaling before inhaling such that the concentrated vapor of the oral rinse is gently forced along with exhaled air from the throat thorough the nasopharynx and the nasal passages of the human, and then inhaling slowly to pass air over the oral rinse in the mouth such that concentrated vapor of the oral rinse is gently forced along with inhaled air through the larynx, over the vocal cords, and through the trachea to the lungs. The method is performed within about one hour after the human experiences the first minor symptom and before the onset of the first major symptom of infection of the respiratory tract.
US08679461B2 Use of hesperetin for enhancing the sweet taste
The use of hesperetin of formula (I) is described wherein the hesperetin of formula (I) is in the form of a (2S)-enantiomer, (2R)-enantiomer or any desired mixture of the two enantiomers, a salt of hesperetin of formula (I), —a mixture comprising or consisting of two or more salts of the hesperetin of formula (I), or a mixture comprising or consisting of hesperetin of formula (I) and one or more salts of hesperetin of formula (I) for enhancing the sweet taste of a sweet-tasting substance or sweet olfactory impression of a flavoring which gives a sweet olfactory impression.
US08679460B2 Low osmolar X-ray contrast media formulations
The present invention generally relates to nonionic x-ray contrast media formulations, radiological compositions containing such agents and methods for x-ray visualization utilizing such compositions. The invention especially relates to injectable radiological compositions for x-ray visualization comprising a pharmaceutically acceptable vehicle and a mixture of a monomer, being a triiodo-substituted benzene nucleus, and a dimer, being two linked triiodo-substituted benzene nuclei, such that the mixture demonstrates favorable properties.
US08679457B2 Metabolite biomarkers to distinguish Crohn's disease from ulcerative colitis and methods using the same
The present invention provides various biomarkers of inflammatory bowel disease, including biomarkers for Crohn's disease and biomarkers for Ulcerative colitis. The present invention also provides various methods of using the biomarkers, including methods for diagnosis of inflammatory bowel disease, methods for distinguishing between inflammatory bowel diseases, methods of determining predisposition to inflammatory bowel disease, methods of monitoring progression/regression of inflammatory bowel disease, methods of assessing efficacy of compositions for treating inflammatory bowel disease, methods of screening compositions for activity in modulating biomarkers of inflammatory bowel disease, methods of treating inflammatory bowel disease, as well as other methods based on biomarkers of inflammatory bowel disease.
US08679455B2 Radiolabelling methods
The invention relates to radiodiagnostic and radiotherapeutic agents, including biologically active vectors labelled with radionuclides. It further relates to methods of making such radiodiagnostic and radiotherapeutic agents and the compounds used in such methods. The resultant labelled conjugates are useful as diagnostic agents, for example, as radiopharmaceuticals more specifically for use in Positron Emission Tomography (PET) or Single Photon Emission Computed Tomography (SPECT) or for radiotherapy.
US08679454B2 Particle immobilized coatings and uses thereof
Surface coatings including microparticles immobilized in a matrix of polymeric material on a substrate are described. The microparticles can also include an agent which can be useful for various applications, such as medical applications.This invention relates to the field of surface coatings for use in various applications. More particularly, the invention relates to surface coating useful for drug delivery, imaging and other uses of microparticles immobilized via a polymeric matrix.
US08679450B2 Process to prepare a hydrogen rich gas mixture
Process to prepare a hydrogen rich gas mixture from a halogen containing gas mixture comprising hydrogen and at least 50 vol. % carbon monoxide, on a dry basis, by contacting the halogen containing gas mixture with water having a temperature of between 150 and 250° C. to obtain a gas mixture poor in halogen and having a steam to carbon monoxide molar ratio of between 0.2:1 and 0.9:1 and subjecting said gas mixture poor in halogen to a water gas shift reaction wherein part or all of the carbon monoxide is converted with the steam to hydrogen and carbon dioxide in the presence of a catalyst as present in one fixed bed reactor or in a series of more than one fixed bed reactors and wherein the temperature of the gas mixture as it enters the reactor or reactors is between 190 and 230° C.
US08679447B2 Process for producing sulfur dioxide and sulfur trioxide
SO3 is formed from a replenished circulating inventory of fresh and recycled SO2. Also, a feed stream of replenished SO2 is heated by indirect heat exchange with a hot stream of SO2 and SO3 whereby the hot stream is cooled for separating the two gases. The heated feed stream of replenished SO2 serves as a hot gaseous feed to a sulfur burner. This SO2 feed is divided into two feed streams, one being oxygenated with pure oxygen and the other remains as an SO2 feed. These feeds plus a feed of molten sulfur are concurrently and separately introduced into the sulfur burner where additional SO2 is formed via continuous exothermic reaction. Although heated, the oxygenated feed(s) of SO2 bring in the needed oxygen for the reaction and the feeds of the oxygenated and non-oxygenated SO2 serve as a heat sink in the sulfur burner to reduce the temperature therein.
US08679441B2 Method of optimizing the control of a fume treatment centre for a carbon block baking ring furnace
The invention relates to a method for controlling a fume treatment center (FTC) (23), scrubbing the baking fumes from a rotary baking furnace (1), in which the fumes are drawn in through at least one suction manifold (11) of the baking furnace (1) and collected in a duct (20, 20′) that conveys said fumes to the fume treatment center (23). The fume treatment center includes a tower (24) which sprays water into the fumes in order to cool same and a least one reactor (25) for the physico-chemical neutralization of the fumes, comprising contact with a reagent powder, such as alumina, followed by filtering (36) of the loaded reagent and the fume dust and recycling in the reactor (25) of at least one fraction of the filtered reagent and mixing of the same with fresh reagent. The method includes at least the following steps: the flow of water in the cooling tower (24) is adjusted and/or the flow and/or recycling rate of the reagent in the reactor (25) is adjusted as a function of at least one parameter indicating the level of pollution of the fumes at the inlet of the fume treatment center (23). The invention can be used for baking carbon cathodes and anodes for aluminum electrolysis.
US08679437B2 Preparation of mesoporous and macroporous silica gel
The present application discloses a process for preparing silica particles, said process comprising the step of mixing (I) an aqueous phase and (II) an oily phase comprising pre-polymerized tetraalkoxy orthosilicate, one or more alcohols, and optionally one or more polyalkylene glycols, wherein said aqueous phase comprises, in an aqueous solvent, one or more C6-30-alkyl modified polysaccharides, and optionally one or more polyalkylene glycols.
US08679432B2 Adsorber having inner coating
The invention relates to an adsorber, including a reaction chamber, an adsorbent having adsorption properties enabling the at least partial removal of water from a gas stream including NOx and/or SOx, and a coating essentially consisting of a polymer material on at least a portion of the inner metal wall of the reaction chamber, said polymer being resistant to the acidic liquids at temperatures above 150° C.
US08679427B2 Process for neutralizing bauxite dissolution residual substance and process for producing aluminum hydroxide
A process for neutralization is provided which can maintain a high solid content of a bauxite dissolution residual substance slurry even after a neutralization treatment is completed and the stabilize pH within a short time of the neutralization treatment. Such a process for neutralizing a bauxite dissolution residual substance containing a desiliconizing product which is generated in the production process of aluminum hydroxide using Bayer process, includes: mixing a bauxite dissolution residual substance or a bauxite dissolution residual substance slurry with sulfuric acid in an amount ranging from 0.6 to 1.2 equivalence to the total amount of sodium contained in the bauxite dissolution residual substance or a bauxite dissolution residual substance slurry, such that the solid content after mixing becomes 400 to 700 g/l to gelate the mixture, and thereafter obtaining a bauxite dissolution residual substance neutralized slurry.
US08679425B2 Reagent container and reagent set
A reagent container set is disclosed which comprises: a first reagent container for accommodating a first reagent to be used in a sample analyzer, the top part of the first reagent container having a first aspiration opening for inserting a first reagent aspirating tube to aspirate the first reagent; a waste fluid container for accommodating the first reagent used in the sample analyzer as a waste fluid, the top of the waste fluid container having a discharge opening for inserting a waste fluid discharging tube to discharge the waste fluid into the waste fluid container; a box for accommodating the first reagent container and the waste fluid container; and a container holding member for holding the first reagent container and the waste fluid container so that the first aspiration opening and the discharge opening are disposed at predetermined positions, the container holding member being maintained at a predetermined position within the box.
US08679419B2 Sterile packing and sterilization method using this packing
This sterile packing (1) includes:—a container (3) for containing at least an object (2) to be sterilized by at least a sterilizing fluid, said container (3) including at least a first opening (10);—at least one first membrane (16) made in a material porous to the sterilizing fluid but non-porous with respect to microbial contamination, said at least one first membrane (16) being sealed at said at least a first opening (10) of the container (3), after filling of the container (3) with the object (2) so as to close said at least a first opening (10);—at least one second membrane (22) made in a flexible and airtight material, said second membrane (22) being sealed at said at least first opening (10) of the container (3), after installation of said first membrane (16), the sealing of said second membrane (22) being carried out at a pressure higher than the atmospheric pressure, so that said second membrane (22) is curved when the packing (1) is brought back to the atmospheric pressure.
US08679418B2 Substrate fabrication
Systems and methods for fabricating bodies (e.g., porous bodies) are described. Various aspects provide for reactors and the fabrication of reactors. Some reactors include surfaces that provide for heterogeneous reactions involving a fluid (and/or components thereof). A fluid may be a gas and/or a liquid. A contaminant in the fluid (e.g., a dissolved or suspended substance) may react in a reaction. A contaminant may be filtered from a fluid. Some reactors provide for independent control of heat transfer (between the fluid, the reactor, and the environment) with respect to mass transfer (e.g., fluid flow through the reactor).
US08679417B2 Headless suspended lass transfer and reaction tower
A headless suspended mass transfer and reaction tower system used for the scrubbing, stripping or chemical reaction between gases and liquids. The system comprises an elongated shell having a closed top end and a suspension member configured to suspend the tower from an external suspension support. Various embodiments of the system can be adapted for the purposes of chemical vent scrubbing, absorption, odor abatement, gas-liquid chemical reactions, or similar processes. The tower can be operated in the classical counter current or concurrent flow modes, under pressure, or in a partial vacuum.
US08679416B2 Fluid treatment system
There is described a fluid treatment system. The fluid treatment system comprises: an open channel for receiving a flow of fluid and a fluid treatment zone. The fluid treatment zone comprising a plurality of elongate radiation source assemblies orientated such that: (i) a longitudinal axis of each radiation source assembly is transverse to a direction of fluid flow through the fluid treatment zone, and (ii) an end of each radiation source assembly is disposed above a predetermined maximum height of fluid flow in the open channel. A first baffle plate is disposed upstream of the fluid treatment zone. The first baffle plate is positioned such that a distal end thereof is below the predetermined maximum height of fluid flow in the open channel. In a preferred embodiment, the present fluid treatment system provides for an area in which a cleaning system for the radiation source assemblies can be “parked” when not in use. In the so-called “parked” position, the cleaning system may be readily accessed for servicing and the like without affecting the flow of fluid through the fluid treatment zone and a fluid treatment system. This is as significant advantage of the fluid treatment system.
US08679414B2 Desulfurization-denitration apparatus for exhaust gas
Adsorbent dust can be recovered while spraying is prevented. An apparatus is provided with a desulfurization-denitration tower body and an adsorbent discharging device. An entrance louver and an exit louver are provided for forming a packed moving bed of an adsorbent that moves downward inside the tower body, the apparatus has a throttle portion provided with a side panel that is inclined so that a spacing gradually decreases toward a discharging device, the throttle portion being provided between the tower body and the discharging device, and first partitions are provided inside the throttle portion. A second partition extending along the incline direction of the side panel is provided at a predetermined distance from the bottom end of the exit louver above the side panel, and a gap is provided between the bottom end part of the exit louver and the side panel of the throttle portion.
US08679409B2 Filter device, filter method and trace detector
The present invention discloses a filter device. The filter device comprises a housing with an air inlet and an filtered air outlet; a high voltage electric field region provided between two ends of the housing, wherein the direction of the electric field is perpendicular to the direction along which the air is introduced into the housing; an ionization source provided in the electric field region to ionize the ionizable pollutants present in the air introduced from the air inlet and form the resultant ionized pollutants which will move towards both ends of the housing under the influence of the electric field; and a discharging device for discharging the ionized pollutants which have arrived at the ends of the housing out of the filter device. The present invention also relates to a filtering method of using the filter device, and a trace detector. The filter device can be used to ionize the ionizable interferents existed in the air, separate the ionized interferents from the other components of the air under the influence of the electric field, and discharge the interferent out of the filter device, thereby reducing the consumption of the consumables or even eliminating the need for consumables. The filter device in accordance with the present invention is applicable to a trace detector based on ion mobility technology for the detection of trace amounts of substances.
US08679408B2 Total organic carbon analysis
The present invention provides an apparatus and method for measuring carbon (any one or all of TC, TOC, or TIC) in a sample matrix. In an embodiment, a method for measuring carbon in a sample composition is provided. The method comprises providing an apparatus comprising a reaction chamber and a diamond coated electrode, wherein the diamond coated electrode is doped with boron. The apparatus further comprises a detector. In addition, the method comprises contacting the sample composition with the electrode. The method further comprises applying an alternating current to the electrode at a sufficient voltage to produce carbon dioxide. Moreover, the method comprises measuring the amount of carbon dioxide produced.
US08679406B2 Automated developer for immuno-stained biological samples
Disclosed herein are systems and methods for the developing of immuno-stained biological samples. The systems disclosed herein are automated and are configured to control one or more steps of the developing procedure. Reagents may be added using automatic syringe dispensing. Reagent temperature, reagent stirring, and wash procedures are programmable and can be separately controlled for separate immuno-staining procedures that are performed at the same time.
US08679401B2 Microwave disinfection and sterilization
A method and apparatus comprising microwave radiation pulses to reduce a microorganism population in an object.
US08679398B2 Balloon folding technology
An apparatus for folding a pre-pleated catheter balloon comprises a stationary base member; a rotatable drive hub which is moveable in relation to the stationary base member; and a folding head aligned with respect to the stationary base member and to the rotatable drive hub. The folding head includes at least three segments, each having a proximal end and an angled distal end with at least one angled side face terminating in an edge of a predetermined length. The segments are arranged so that the segment distal ends are disposed adjacent to and defining a central aperture The segment distal ends move closer to the central point upon rotation of the rotatable hub member in a predetermined direction, whereby the balloon is folded around the shaft substrate upon rotation of the rotatable hub.
US08679393B1 Electromagnetic interference and radio frequency absorbing material and process for forming the same
A method for producing an EMI/RF absorbing material including dispersing metallic flakes in a resin. The method also includes providing a first coat of the resin containing dispersed metallic flake to form a first layer. The method further includes providing a second coat of the resin containing dispersed metallic flake to the first layer to form a second layer. At least one of the first or second layers has a substantially uniform distribution of metallic flake throughout a thickness of the first or second layers.
US08679392B2 Process to form a mold of nanoimprint technique for making diffraction grating for DFB-LD
A process using the nanoimprint technique to form the diffraction grating for the DFB-LD is disclosed. The process includes (a) coating a resist for the EB exposure on a dummy substrate, (b) irradiating the resist as varying the acceleration voltage, (c) forming a resist pattern by developing the irradiated resist, (d) coating the SOG film on the patterned resist, (e) attaching the silica substrate on the cured SOG film, and (f) removing the dummy substrate with the resist from the SOG film and the silica substrate. Using the mold thus formed, the diffraction grating for the DFB-LD is formed by the nanoimprint technique.
US08679382B2 Tire uniformity correction
Improved methods and apparatus are disclosed for correcting one or more uniformity characteristics in a tire and particularly to correction in a low profile tire or a tire having a projection along the sidewall. The uniformity characteristic may be a radial force variation, conicity, or both. Correction is accomplished by stretching portions of the tire architecture to create permanent deformation.
US08679381B1 Carbon fiber foam composites and methods for making the same
Exemplary embodiments provide methods and apparatus of forming fibrous carbon foams (FCFs). In one embodiment, FCFs can be formed by flowing a fuel rich gas mixture over a catalytic material and components to be encapsulated in a mold to form composite carbon fibers, each composite carbon fiber having a carbon phase grown to encapsulate the component in situ. The composite carbon fibers can be intertwined with one another to form FCFs having a geometry according to the mold.
US08679376B2 Dichroic dye for use in polarizing film, polarizing film, and display device including the polarizing film
A polarization film, including a polymer resin, and a dichroic dye dispersed in the polymer resin and represented by the following Chemical Formula 1: wherein, in Chemical Formula 1, Ar, R1 to R4 are the same as those defined in the detailed description.
US08679375B2 Carbon blacks-free sulfur-vulcanised electrically conductive rubber blends
A practical and environmentally-friendly method, i.e. the high temperature-mechanical mixing by using an internal mixing device and a two-roll open milling device is used to produce the carbon blacks-free electrically conductive sulfur-vulcanised rubber blends of solid poly(butadiene-co-acrylonitrile) and solid sulfonic acid doped polyaniline. The addition of sulfur vulcanization system does not affect the electrical properties of the vulcanised blends. All vulcanised blends prepared by using this method show useful electrical conductivities up to the order of 10−2 S/cm, good tensile strengths up to 18.0 MPa and colorable with the addition of a whitening agent. As a result, they have good potential to be used for manufacturing any antistatic products, electrostatic discharge or dissipative products and electromagnetic or radio frequency interferences shielding products.
US08679373B2 Composition of matter tailoring: system I
The present invention relates to new compositions of matter, particularly metals and alloys, and methods of making such compositions. The new compositions of matter exhibit long-range ordering and unique electronic character.
US08679370B2 Conductive coating, method for preparing a coating, roller, and method for manufacturing a roller and using a coating
A conductive coating is described, suitable for coating a developer, charge or transfer roller in a developing apparatus to give a charge providing layer. The coating comprises a conductive polymer in a matrix. A roller is also described, suitable for a developing apparatus comprising, from the center to the periphery, a conductive mandrel, a conductive elastic base layer and a charge providing layer.
US08679369B2 Film-forming material and method for predicting film-forming material
Disclosed is a method for prediction of a film material such as a raw material for organic EL. In the method, a film material having an evaporation rate (V(%)) represented by the formula below can be predicted based on the values of the constant (Ko) and the activation energy (Ea). V=(Ko/P)×e−Ea/kT wherein Ko represents a constant (%·Torr), P represents a pressure (Torr), Ea represents an activation energy (eV), k represents a Boltzmann constant, and T represents an absolute temperature.
US08679366B2 Cleaning composition containing a polysaccharide graft polymer composition and methods of controlling hard water scale
A composition includes a polysaccharide graft polymer composition and 2-phosphonobutane-1,2,4-tricarboxylic acid. In one embodiment, the polysaccharide graft polymer composition includes a polysaccharide residue present in an amount from approximately 5% to approximately 90% by weight of the polysaccharide graft polymer composition and a residue of acrylic acid, methacrylic acid or a combination thereof present in an amount from approximately 10% to approximately 75% by weight of the polysaccharide graft polymer composition.
US08679360B2 Base surface processing method and MEMS device
A base surface processing method includes forming a protective film on a base surface; thinning a part of a base by grinding a part of the base surface; and etching a ground surface ground by the thinning.
US08679351B2 Process and apparatus for decontaminating water by producing hydroxyl ions through hydrolysis of water molecules
A water decontaminization system and method which utilizes an apparatus for producing hydroxyl ions through hydrolysis of water molecules to oxydize contaminents in the water. The apparatus includes a water chamber with an input water conduit and an output water conduit to establish a water flow in the chamber, in which electrodes positioned in the water chamber apply a voltage potential which causes electric current to flow through the water to create hydroxyl ions in the water, in a manner effective to kill contaminents such as viruses, bacteria, algae, organic substances, etc.
US08679350B1 Acidic mine water remediation
A process for treating acidic mine drainage water to remove heavy metal ions is described in which acidic mine drainage water is contacted with direct process residue gel.
US08679347B2 Multi-use high water recovery process
Disclosed is a versatile multi-use high water recovery process that integrates the use of water purification membranes including reverse osmosis and nanofiltration with ion exchange water softening resins in a number of configurations that optimize operation and achieve maximum membrane permeate recoveries while eliminating the use of fresh water, sodium chloride and other chemicals needed to regenerate the IX resin. The invention provides process mobility and flexibility that enable selection of optimum process configurations and features to address variability in the Influent Water quality.
US08679345B2 Control system and method for flash separation
Provided are methods and apparatus for determining conditions for performing chromatography, particularly flash chromatography. The methods may be utilized for separating compounds in a sample in a column chromatography system. The method includes determining at least two retention factors corresponding to the TLC performance of a target compound and an adjacent compound and defining a sample loading amount and a solvent gradient profile using at least two solvents that will result in differential elution of the target and adjacent compounds from a chromatography column. The chromatography system and loading parameters may be selected to provide satisfactory separation of the target compound from adjacent compounds.
US08679344B2 Process for solvent shifting a nanoparticle dispersion
A process for replacing the continuous phase of a nanoparticle dispersion with a less polar phase, includes filtering the dispersion through a semi-permeable membrane filter to remove the continuous phase, and introducing a less polar phase.
US08679340B1 Method to stimulate and sustain the anaerobic biodegradation of light non-aqueous phase liquid
A method for treating LNAPL source zones using a cost effective LNAPL source zone technology to degrade residual LNAPL, by introducing bioremediation amendments comprising nutritional supplements in quantities, locations, and depths required to stimulate and sustain the anaerobic biodegradation of an LNAPL source zone; monitoring the LNAPL source zone for adverse conditions that decrease anaerobic LNAPL biodegradation; eliminating any identified adverse conditions to sustain LNAPL biodegradation; and maintaining the water with nutritional supplements in quantities, locations, and depths required to stimulate and sustain the anaerobic biodegradation of LNAPL.
US08679329B2 Filter system for positioning within a storm water sewer
A filter system for a storm water sewer includes a flat mount frame with inwardly projecting support wires and seats on an internal ledge of a grate frame supporting a removable grate. A fabricated circular wire basket has welded cross wires defining openings in side and bottom walls and is lined with a porous filter fabric for collecting silt within storm water flowing through openings in the grate. The wire basket has upwardly projecting bent wire portions hooked onto the support wires of the mount frame and define overflow passages and handle openings for removing the mount frame and the basket after the grate is removed. A smaller and lined lift-out wire basket is supported within a lower portion of the wire basket attached to the mount frame, and each wire basket may be compressed laterally into an oval configuration for use with a rectangular mount frame.
US08679327B2 Bioretention box
The bioretention box includes a vault, a lid and a removable grate positioned within the lid, the combination of the vault, lid and grate being positionable with a dugout subgrade region and capable of supporting vehicular traffic within a parking area. Within the bioretention box is a treatment region to remove contaminants from storm water ingress. The treated water moves through openings in the bottom of the vault or through pipes to outside the vault, to a storm drain. The bioretention box includes overflow pipes which accommodate heavy storm water flows.
US08679326B2 Medical apparatus for extracorporeal treatment
A medical apparatus (100) for extracorporeal blood treatment comprises a support structure (101) housing a hydraulic circuit (1) located above a liquid collection zone (103) such that liquid losses from the hydraulic circuit can at least partially accumulate at the liquid collection zone. A liquid sensor (108) detects presence of any liquid in the liquid collection zone and operates in a distanced position with respect to the liquid collection zone (103).
US08679325B2 Processing asphaltene-containing tailings
Embodiments of a method and a system for recovering energy, materials or both from asphaltene-containing tailings are disclosed. The asphaltene-containing tailings can be generated, for example, from a process for recovering hydrocarbons from oil sand. Embodiments of the method can include a flotation separation and a hydrophobic agglomeration separation. Flotation can be used to separate the asphaltene-containing tailings into an asphaltene-rich froth and an asphaltene-depleted aqueous phase. The asphaltene-rich froth, or an asphaltene-rich slurry formed from the asphaltene-rich froth, then can be separated into a heavy mineral concentrate and a light tailings. Hydrophobic agglomeration can be used to recover an asphaltene concentrate from the light tailings. Another flotation separation can be included to remove sulfur-containing minerals from the heavy mineral concentrate. Oxygen-containing minerals also can be recovered from the heavy mineral concentrate. Water removed by the various separation steps can be recycled and its heat energy recovered.
US08679321B2 Process for increasing benzene and toluene production
A process for reforming a hydrocarbon stream is presented. The process involves splitting a naphtha feedstream to at least two feedstreams and passing each feedstream to separation reformers. The reformers are operated under different conditions to utilize the differences in the reaction properties of the different hydrocarbon components. The process utilizes a common catalyst, and common downstream processes for recovering the desired aromatic compounds generated.
US08679318B2 Electrolyte supplement system in aluminium electrolysis process and method for preparing the same
The disclosure provides an electrolyte supplement system in an aluminum electrolysis process, which includes low-molecular-ratio cryolite, wherein the low-molecular-ratio cryolite is selected from mKF.AlF3, nNaF.AlF3 or mixture thereof, where m=1˜1.5 and n=1˜1.5. When the electrolyte supplement system provided by the disclosure is applied to the aluminum electrolytic industry, electrolytic temperature can be reduced obviously in the aluminum electrolysis process without changing the existing electrolytic process; thus, power consumption is reduced, volatilization loss of fluoride is reduced and the comprehensive cost of production is reduced.
US08679312B2 Gas sensor system and method for controlling gas sensor
A gas sensor system including a gas sensor; a current control unit; a constant control unit; and a temperature acquisition unit. The gas sensor includes a measurement chamber, a pump cell and an electromotive force cell. The current control unit performs feedback control on current flowing through the pump cell in response to the voltage of the electromotive force cell and in accordance with a control constant which characterizes the feedback control. Further, the constant control unit changes the control constant of the feedback control in accordance with a value (for example, a resistance value of the electromotive force cell) corresponding to the temperature of the gas sensor.
US08679309B2 Test sensors and methods of using side mounted meter contacts
An electrochemical test sensor includes a lid and a base. The base has a length and a width. The length of the base is greater than the width of the base. The base includes at least a working electrode, a counter electrode and at least three test-sensor contacts for electrically connecting to a meter. The at least three test-sensor contacts are spaced along the length of the base from each other. The base and the lid assist in forming a fluid chamber for receiving the fluid sample. The electrochemical test sensor further includes a reagent to assist in determining the concentration of the analyte in the fluid sample.
US08679306B2 Sputtering apparatus
A sputtering apparatus with high usage efficiency of a target is provided. A sputtering apparatus of the present invention includes first and second ring magnets, first and second magnet members arranged inside a ring of the first and second ring magnets, wherein in the first and second ring magnets and the first and second magnet members, magnetic poles with the same magnetism are faced toward the rear surface of a first and a second targets. Thus, in the rear surface of the first and second targets, the magnetic poles with the same polarity are adjacently arranged, and the absolute value of the strength of horizontal magnetic field components formed in the surfaces of the first and second targets becomes small and the strength distribution becomes narrow, and the strength of vertical magnetic field components becomes uniform; and consequently, a non-erosion portion is not produced in the first and second targets.
US08679303B2 Refillable anode
A liquid heating system may comprise a metallic container and a refillable non-corrosive hollow porous tube, which may be coupled to the metallic container. The refillable non-corrosive hollow porous tube may include at least one open end and anodic material may be filled or refilled into the refillable non-corrosive hollow porous tube through the at least one open end. The anodic material is corroded by the oxidation process at a substantially faster rate compared to the metallic container. The anodic material is refilled into the refillable non-corrosive hollow porous tube through the at least one open end without removing the refillable non-corrosive hollow porous tube from the metallic container or disturbing the position of the refillable non-corrosive hollow porous tube.
US08679302B2 Silicon titanium oxide coating, coated article including silicon titanium oxide coating, and method of making the same
Certain example embodiments relate to a layer of or including Ti1-xSixOy and/or a method of making the same. In certain example embodiments, the Ti1-xSixOy-based layer may be substoichiometric with respect to oxygen. In certain example embodiments of this invention, the layer may include Ti1-xSixOy where x is from about 0.05 to 0.95 (more preferably from about 0.1 to 0.9, and even more preferably from about 0.2 to 0.8, and possibly from about 0.5 to 0.8) and y is from about 0.2 to 2 (more preferably from about 1 to 2, and even more preferably from about 1.5 to 2, and possibly from about 1.9 to 2). The layer may have an index of refraction of from about 1.6 to 1.9. The layer may also be used with a transparent conductive oxide in a transparent conductive coating.
US08679298B2 Remotely controlled decoking tool used in coke cutting operations
The present a system structured to allows an operator to remotely switch between cutting and boring while removing solid carbonaceous residue from large cylindrical vessels called coke drums utilizing—a cutting head for ejecting high pressure fluids into the coke bed; a flow diversion apparatus; and a shifting apparatus.
US08679295B2 Soft creped tissue
The present disclosure relates generally to a tissue product having a creping composition disposed onto at least one surface thereof to increase the softness of the article, while retaining or improving manufacturing efficiency. Preferably the creping composition comprises a first component that is cationic and a second component that is capable of forming a film. Preferably both the first and second components are water soluble. The first component carries a cationic charge that is capable of forming ionic bonds with the negatively charged fibers of the tissue web, thus providing a retention mechanism by which the creping composition is retained. The overall retention of the creping composition reduces the concentration of the composition in the machine process water, improving machine operability and runability.
US08679290B2 Exfoliation of graphene by multilayer coextrusion
Exfoliation of graphene from graphite using multilayer coextrusion is generally disclosed. In some example embodiments, graphite may be dispersed within a first processing material, and the first processing material and a second processing material may be co-extruded through a plurality of series coupled layer multiplication dies to exfoliate graphene from the graphite. The graphene may be separated from the resulting multi-layered material. In some example embodiments, graphite flake and/or expanded graphite may be dispersed within the first processing material.
US08679288B2 Showerhead electrode assemblies for plasma processing apparatuses
Showerhead electrode assemblies are disclosed, which include a showerhead electrode adapted to be mounted in an interior of a vacuum chamber; an optional backing plate attached to the showerhead electrode; a thermal control plate attached to the backing plate or to the showerhead electrode at multiple contact regions across the backing plate; and at least one interface member separating the backing plate and the thermal control plate, or the thermal control plate and showerhead electrode, at the contact regions, the interface member having a thermally and electrically conductive gasket portion and a particle mitigating seal portion. Methods of processing semiconductor substrates using the showerhead electrode assemblies are also disclosed.
US08679283B2 Bonding method and bonded body
A bonding method of bonding two base members together through a bonding film is provided. The bonding method is a method for forming a bonded body in which a first base member and a second base member are bonded together through the bonding film. The bonding method includes: applying a liquid material containing a silicone material composed of silicone compounds onto a surface of at least one of the first and second base members to form a liquid coating on the surface; drying the liquid coating so that it is transformed into the bonding film on the surface of the at least one of the first and second base members; and applying energy to the bonding film so that a bonding property is developed in the vicinity of a surface thereof, to thereby bond the first and second base members together through the bonding film.
US08679281B2 Method of making a building material having a selvage edge
A method of forming a building material with a pre-applied adhesive, the method comprising the steps of manipulating a first membrane and a second membrane to be spaced from one another along parallel adjacent edges to form a gap; securing a single strip of adhesive tape to a top surface of both said first and second membranes adjacent to said adjacent edges so that said adhesive tape extends over said gap; and cutting along the length of said adhesive tape to form a first adhesive tape and a second adhesive tape, said first adhesive tape being secured to the top surface of said first membrane and extending over a portion of said gap, and said second adhesive tape being secured to the top surface of said second membrane and extending over a portion of said gap.
US08679277B2 Napkin apparatus and method
A method is provided that includes peeling at least one carrier strip away from an adhesive layer of an adhesive article. The adhesive article includes a flexible substrate with the adhesive layer thereon, wherein the adhesive layer remains mounted to the flexible substrate of the adhesive article after the carrier strip is peeled away, wherein the adhesive article is operative to disintegrate when submerged in water. The method also includes using the adhesive article to adhesively mount a cloth or paper napkin to clothing being worn by a person. The carrier strip or adhesive article may include advertising and/or a coupon printed thereon, which may be taken away by the person after the meal.
US08679276B2 Non-compliant medical balloon
A non-compliant fiber-reinforced medical balloon comprises a first fiber layer and a second fiber layer embedded in a continuous matrix of thermally-weldable polymer material defining a barrel wall, cone walls and neck walls. The fibers of the first fiber layer have a pattern of different lengths and are divisible into a first group and a second group based on length. The length of the fibers of the second group varies progressively in accordance to their proximity to the fibers of the first group; the fibers of the second group closest to the fibers of the first group being longer than the fibers of the second group further from the fibers of the first group. The fiber of the second fiber layer winds circumferentially around the longitudinal axis of the balloon substantially over the entire length of the balloon.
US08679275B2 Composite tie rod and method for making the same
A composite tie rod comprises an open lattice body formed of interlaced filaments held in a solid matrix. A pair of composite fittings bonded to the ends of the body rigidly connect rod ends with the body. The rod ends form attachment points on the tie rod.
US08679273B2 Systems and methods for providing vacuum encapsulation for climate control panels
A climate control system according to implementations of the invention includes one or more vacuum chambers. The vacuum chamber is encompassed by a chamber wall that is substantially impervious to gases. The vacuum chamber houses one of several combinations. In one combination, the near vacuum has yet to be created, and the vacuum chamber houses substantially-pure carbon dioxide and un-reacted carbon dioxide reducing agent. In a second combination, the near vacuum has been created, and the vacuum chamber houses reaction products of a chemical reaction between substantially-pure carbon dioxide and carbon dioxide reducing agent in a near vacuum. Various methods are used for creating vacuum chambers and for generating near vacuum conditions within such chambers. Various systems and structures can utilize such vacuum chambers and panels containing such chambers.
US08679272B2 Run-flat pneumatic tire assembly and method
A run-flat pneumatic tire assembly includes a pneumatic tire having an elastomeric casing and a tire cavity formed therein. A longitudinally-extending and approximately planar length of strip material is helically arranged within the tire cavity to pre-stress the length of strip material for usage of the pneumatic tire during under-inflated and non-inflated conditions. A method of making a run-flat pneumatic tire assembly is also included.
US08679259B2 Substrate processing apparatus, method of manufacturing semiconductor device and method of cleaning processing vessel
When a dry cleaning process is performed in a processing chamber by adding nitrogen monoxide (NO) gas to a cleaning gas, the handling is facilitated, and cleaning performance is improved. A substrate processing apparatus includes a processing vessel configured to process a substrate, a first cleaning gas supply system configured to pre-mix a gas containing fluorine atoms with the NO gas and supply the pre-mixed gas into the processing vessel, and a second cleaning gas supply system installed apart from the first cleaning gas supply system and configured to supply the fluorine-containing gas into the processing vessel.
US08679258B2 Washing plant
Washing plant to perform a washing cycle of objects providing at least a pre-wash operation and a washing and heat disinfecting the objects operation. The plant includes a first battery of pre-wash units, in series one after the other along a first alignment axis and a second battery of washer and heat disinfection machines along a second alignment axis, different from the first alignment axis to operate parallel with each other and perform object washing and heat disinfecting. The second battery is able to receive, along a feed direction transverse to the second alignment axis, the objects subjected to pre-wash exiting from the first battery along the first axis alignment. The second battery feed direction is also transverse to the first alignment axis. Movement members are provided to divert the objects exiting from the first battery and direct them, aligned with the direction of feed, towards the second battery.
US08679248B2 GaN whiskers and methods of growing them from solution
Millimeter-scale GaN single crystals in filamentary form, also known as GaN whiskers, grown from solution and a process for preparing the same at moderate temperatures and near atmospheric pressures are provided. GaN whiskers can be grown from a GaN source in a reaction vessel subjected to a temperature gradient at nitrogen pressure. The GaN source can be formed in situ as part of an exchange reaction or can be preexisting GaN material. The GaN source is dissolved in a solvent and precipitates out of the solution as millimeter-scale single crystal filaments as a result of the applied temperature gradient.
US08679246B2 Preparation of amorphous mixed metal oxides and their use as feedstocks in thermal spray coating
Amorphous mixed metal oxides are used as a feedstock for thermal spray coating. Compared to thermal spray coating methods utilizing crystalline metal oxide feedstocks, the present method reduces energy consumption and expands the range of feedstock chemical compositions. The present method also produces coatings with improved chemical homogeneity. Methods of preparing the amorphous mixed metal oxides are also described.
US08679244B2 Asphalt compositions modified by styrenic block copolymer and vegetable wax
Disclosed is a modified asphalt composition including a styrenic block copolymer and a vegetable wax as modifier. With lower viscosity at high temperatures as compared to the asphalt composition modified only with the styrenic block copolymer, it can be manufactured and used at lower temperatures. Also, with higher ductility at low temperatures, it can minimize fatigue crack even in cold weathers.
US08679243B2 Aqueous pigment dispersion used for preparing ink jet recording aqueous ink, and ink jet recording aqueous ink
An aqueous pigment dispersion used for preparing an ink jet recording aqueous ink comprises an anionic group-containing organic polymeric compound, an organic pigment, an organic pigment derivative, and the water, wherein the polymeric compound, the organic pigment, and the organic pigment derivative are dispersed in water, the organic pigment and the organic pigment derivative are a diketopyrrolopyrrole-based red pigment and a phthalimidoalkylated quinacridone, respectively, and the phthalimidoalkylated quinacridone content is in the range of 1.6 to 3.8% relative to the total (100%) of the diketopyrrolopyrrole-based red pigment and the phthalimidoalkylated quinacridone on a mass basis. Furthermore, there is provided an ink jet recording aqueous ink containing such an aqueous pigment dispersion, wherein the aqueous pigment dispersion is diluted such that the total of the organic pigment content and the organic pigment derivative content is from 1 to 8% on a mass basis.
US08679242B2 Organic silver complexes, their preparation methods and their methods for forming thin layers
The present invention relates to a silver complex obtained by reacting at least one silver compound represented by the formula 2 below with at least one ammonium carbamate compound or ammonium carbonate compound represented by the formula 3, 4 or 5 below:
US08679241B2 Gas pressure monitor for pneumatic surgical machine
A gas pressure monitor system for a pneumatically-powered surgical machine includes a first transducer, a second transducer, and a controller. The first transducer is located upstream from a filter and is configured to read a first pressure of a gas before the gas enters the filter. The second transducer is located downstream from the filter and is configured to read a second pressure of a gas after the gas exits the filter. The controller is configured to compute a difference between the first pressure and the second pressure. A state of the filter is determined from the difference between the first pressure and the second pressure.
US08679239B2 Adsorbent material and xenon adsorption device using same
An adsorbent comprising a zeolite having a pore diameter of not less than 4.5 angstroms and not more than 7.3 angstroms as a principal component, which can adsorb xenon under ordinary temperatures and pressures or under ordinary temperatures and low xenon partial pressures. In addition, a xenon adsorbing device comprising an adsorbent, a container of a vapor poorly-permeating material, which houses the adsorbent, and a joint part which joins the container to a xenon enclosure space, in which the adsorbent is communicated with the xenon enclosure space. Thereby, the present invention provides an adsorbent which recovers xenon directly from the used equipment in which xenon is enclosed with efficiency under ordinary temperatures and pressures or under ordinary temperatures and low xenon partial pressures, and a xenon adsorbing device using the adsorbent.
US08679237B2 Centrifugal oil separator for an aircraft engine
On a centrifugal oil separator for an aircraft engine for separating the oil particles contained in the vent air, a metallic foam body (7), into which the loaded vent airflow (3) is introduced, is firmly integrated into a hollow-type engine shaft (1), while high-voltage electrodes (6), which electrostatically charge the oil droplets in the vent air, are arranged outside the engine shaft (1) within the vent airflow (3) forwarded to the engine shaft (1). The simply designed oil separator, which can be space-savingly arranged and cost-effectively produced, ensures efficient separation of even minute oil droplets from the air-oil mixture.
US08679236B1 Filtration system and method
Described are multi-stage drum filtration systems including a primary rotary drum filter stage, at least one passive filter stage, and a main fan configured to create a vacuum on an inlet side of the primary rotary drum filter stage. The multi-stage drum filtration system may also include a HEPA filter stage. A controller may be configured to control a speed of the main fan to maintain an inlet vacuum to the primary rotary drum filter stage that corresponds to an inlet vacuum set point input.
US08679230B2 Reducing emissions of VOCs from low-pressure storage tanks
An apparatus and method for reducing or controlling VOC emissions from a low-pressure storage tank for a VOC-containing substance stored or transported as a liquid in the storage tank are provided. The apparatus and method include a filter media operatively positioned between a headspace in the storage tank and the atmosphere, wherein: (i) a gaseous substance from a headspace in the storage tank passes through the filter media to be vented to the atmosphere; (ii) the filter media comprises a permeable substrate and a liquid stripper for a VOC, wherein the liquid stripper coats the permeable substrate; (iii) the filter media provides a gaseous back pressure across the filter media to the atmosphere of less than 1 psig; and (iv) a liquid condensate from the filter media can drip or flow under gravity back into the storage tank.
US08679227B2 High flux SAPO-34 membranes for CO2/CH4 separation and template removal method
The present invention provides methods for making improved zeolite and crystalline silicoaluminophosphate (SAPO) membranes, in particular SAPO-34 membranes, on a porous support through improved removal of the organic structure-directing templating agent. A calcining step is performed in an oxygen free atmosphere, such as under a vacuum or inert gas, to remove the organic templating agent. By removing the templating agent in the absence of oxygen, the calcination step can remove a greater amount of the templating agent than comparable template removal steps conducted in the presence of oxygen and the calcination step can be conducted at significantly lower temperatures. The membranes of the present invention provide increased permeance while maintaining comparable selectivity for gas separations, particularly carbon dioxide (CO2) and methane (CH4) separations and separations at high temperatures.
US08679219B2 Process for preparing an elemental sulphur-containing fertilizer
A process for preparing an elemental sulphur-containing fertilizer is disclosed. The process uses a dispersion mill, wherein a rotor turns within a slotted stator, to wet mill elemental sulphur in a liquid (preferably an aqueous liquid), thereby providing a dispersion of milled elemental sulphur in the liquid. The dispersion is combined with further components to provide a mixture of elemental sulphur and further components, and the mixture is granulated in a granulator unit to provide granulated elemental sulphur-containing fertilizer.
US08679218B2 Filter media with a multi-layer structure
Filter media are described. The filter media may include multiple layers. In some embodiments, the filter media include a nanofiber layer adhered to another layer. In some embodiments, the layer to which the nanofiber layer is adhered is formed of multiple fiber types (e.g., fibers that give rise to structures having different air permeabilities and/or pressure drops). In some embodiments, the nanofiber layer is adhered to a single-phase or a multi-phase layer. In some embodiments, the nanofiber layer is manufactured from a meltblown process. The filter media may be designed to have advantageous properties including, in some cases, a high dust particle capture efficiency and/or a high dust holding capacity.
US08679214B2 Gas cleaning separator
The present invention relates to a separator and more specifically, but not exclusively, to a centrifugal separator for the cleaning of a gaseous fluid. A centrifugal separator is provided as comprising a housing defining an inner space, and a rotor assembly for imparting a rotary motion onto a mixture of substances to be separated. The rotor assembly is located in said inner space and is rotatable about an axis relative to the housing. The rotor assembly comprises an inlet for receiving said mixture of substances, an outlet from which said substances are ejected from the rotor assembly during use, and a flow path for providing fluid communication between the inlet and outlet, wherein the outlet is positioned more radially outward from said axis than the inlet.
US08679212B2 Air cleaner device
An air cleaner device whereby the number of component parts is reduced and the filter element can be maintained and inspected without a time-consuming procedure. The air cleaner device includes: a support part provided to a cleaner case and having a fitting ingress at a region on the opposite side thereof from the cover; and a pivot provided to the cover and having a convex part capable of fitting in the fitting ingress of the support part. A hinge part for connecting the cover to the cleaner case so that the cover can open and close is formed by the support part and the pivot by fitting of the convex part in the fitting ingress.
US08679211B1 Cyclonic separator assembly for a vacuum cleaner
A cyclonic separator assembly for use with a vacuum cleaner includes a body having an inlet, an outlet, and an inner surface. The cyclonic separator assembly also includes a cyclone unit positioned within the body between the inlet and the outlet. The cyclone unit has an outer perimeter that is spaced apart from the inner surface of the body to define an inlet space therebetween. The cyclone unit includes a plurality of first cyclones in communication with the inlet space and arranged along an outer circle adjacent the outer perimeter. The cyclone unit also includes a plurality of second cyclones in communication with the inlet space and arranged along an inner circle that is spaced apart from the outer circle such that each second cyclone is nested between two adjacent first cyclones. The plurality of first cyclones and the plurality of second cyclones are arranged in parallel.
US08679208B2 Cubic boron nitride compact
The present invention relates to PCBN compacts, more specifically, to a PCBN compact comprising cBN; a secondary hard phase selected from the transition metal carbides, nitrides, carbonitrides and mixtures thereof; a superalloy bonding phase; optionally an added transition metal aluminide; and optionally a small amount of a suitable oxide, preferably, aluminum oxide or yt-trium oxide. More particularly, the cBN compact comprises 30 to 70 volume % of a polycrystalline mass of cubic boron nitride particles; 70 to 30 volume % of a matrix phase, and a superalloy. The matrix phase comprises a secondary hard phase selected from a transition metal carbide, nitride, carbonitride and a mixture thereof.
US08679205B2 Method and apparatus for manufacturing hydrogen-containing gas
There is provided a technique and an apparatus for manufacturing a hydrogen-containing gas. An oxygen-containing gas is mixed with a feed gas obtained by mixing steam with a hydrocarbon fuel, this mixture is introduced into a catalytic reaction chamber, and a partial oxidation reaction and a steam reforming reaction are conducted to obtain a hydrogen-containing gas. In this reforming, an antechamber of the catalytic reaction chamber is heated up to a self-ignition temperature in a first catalyst section, where the self-ignition temperature is the temperature at which a mixed gas self-ignites during the advection period required for the mixed gas to move from a mixing chamber to the catalytic reaction chamber, with this temperature being at least a minimum partial-oxidation temperature and lower than a minimum steam reforming temperature.
US08679196B2 Non metal tanning
Tanned leather, skin or pelt is produced by non-metal tanning, comprising the step of tanning a bated hide, skin or pelt with a tanning agent (A), the tanning agent (A) being at least one compound of formula (1), R—NH—Y—SO2—Z (1), wherein R is a radical of formula wherein Hal is fluorine or chlorine, X is N or CR1, Y is an aliphatic, aromatic or aromatic hydrocarbonic bridge which may be optionally be interrupted by a heteroatom or heteroatomic group, Z is vinyl, β-chloroethyl, β-phosphatoethyl or β-sulphatoethyl, R1 is hydrogen or Cl, in a tanning bath, the tanning bath having a pH of from 6 to 10 at the beginning of tanning step.
US08679192B2 System and method for acquiring and processing myoelectric signals in order to control a prosthetic arm
The invention relates to a system for acquiring and processing myoelectric signals in order to control a prosthetic arm, comprising: a pair of electrodes positioned in a muscle in the residual limb of an arm that has been amputated in order to detect myoelectric signals; an electrode positioned at a distance from said pair of electrodes, which acts as an earth system; a myoelectric signal conditioning means; and a prosthesis controlling and processing means which receives conditioned signals from the conditioning means. According to the invention, the prosthesis controlling and processing means includes: a comparison means for comparing a muscle contraction time and a muscle contraction voltage with a threshold time and a threshold voltage, respectively; and an activation means for activating at least one motor which produces a predetermined movement of the prosthesis in response to an activation signal transmitted from the aforementioned comparison means. The electrodes provide the myoelectric signal for activating different movements of the prosthesis, without the electrodes having to be changed to another muscle.
US08679190B2 Hydrogel arthroplasty device
An arthroplasty device is provided having an interpenetrating polymer network (IPN) hydrogel that is strain-hardened by swelling and adapted to be held in place in a joint by conforming to a bone geometry. The strain-hardened IPN hydrogel is based on two different networks: (1) a non-silicone network of preformed hydrophilic non-ionic telechelic macromonomers chemically cross-linked by polymerization of its end-groups, and (2) a non-silicone network of ionizable monomers. The second network was polymerized and chemically cross-linked in the presence of the first network and has formed physical cross-links with the first network. Within the IPN, the degree of chemical cross-linking in the second network is less than in the first network. An aqueous salt solution (neutral pH) is used to ionize and swell the second network. The swelling of the second network is constrained by the first network resulting in an increase in effective physical cross-links within the IPN.
US08679185B2 Joint prosthesis with positionable head
A prosthesis for a joint includes a stem for engagement with a bone. The stem includes a surface defining a bore. The prosthesis further includes a joint component. The joint component includes a bearing surface for articulating engagement with at least one of a natural opposing joint component and a prosthetic opposing joint component. The prosthesis further includes a mounting element. The mounting element includes a proximal portion for engagement with the joint component and further includes a substantially solid articulating portion having a contiguous periphery. The substantially solid articulating portion is configured to facilitate articulating movement of the substantially solid articulating portion within the bore when the contiguous periphery is not forcefully engaged with the bore, and the substantially solid articulating portion and the bore are configured to fixedly couple the mounting element to the stem when the contiguous periphery is forcefully engaged with the bore.
US08679182B2 Spacerless artificial disc replacements
Spacerless artificial disc replacements (ADR) are disclosed. One preferred embodiment includes two saddle-shaped components to facilitate more normal spinal flexion, extension, and lateral bending while limit axial rotation, thereby protecting the facet joints and the annulus fibrosus (AF). Either or both of the superior and inferior components are made of a hard material such as chrome cobalt, titanium, or a ceramic including alumina, zirconia, or calcium phosphate. The articulating surfaces of the ADR are also preferably highly polished to reduce friction between the components. Metals, alloys or other materials with shape-memory characteristics may also prove beneficial.
US08679181B2 Total disc replacement device
The total disc replacement device (1) comprising a central axis (2), a first and a second apposition plate (3; 5), a first and a second joint component (4; 6) being mutually arranged in a ball joint like manner and being located between said first and second apposition plates (3; 5) and intermediate means (7) being disposed at least between the first apposition plate (3) and the first joint component (4) in such manner that, the first joint component (4) is not freely moveable transversely to the central axis (2) with respect to the first apposition plate (3) under load-free conditions, but a limited movement of the first joint component (4) relative to the first apposition plate (3) transversal to the central axis (2) is allowed under load.
US08679180B2 Devices used to treat disc herniation and attachment mechanisms therefore
A method for retaining an intra-discal material within an annulus fibrosis having a posterior annulus, an inside surface, and an opening is described. The opening has a lateral and a vertical dimension. A retention device that includes a shape memory alloy is inserted through the opening in the annulus fibrosis. The length dimension of the device is longer than the lateral dimension of the opening and the width dimension of the device is longer than the vertical dimension of the opening in the annulus fibrosis. The retention device is positioned against the posterior annulus to rest against annulus fibrosis tissues adjacent the opening on the inside surface of the annulus fibrosis such that both a portion of the length dimension and a portion of the width dimension rests against annulus fibrosis tissues adjacent the opening. The retention device prevents the escape of intra-discal material through the opening.
US08679178B2 Extra-articular implantable mechanical energy absorbing assemblies having two deflecting members and compliance member
Implantable assemblies for manipulating energy transferred by members defining an anatomical joint, and methods of implanting and using. The members of the anatomical joint collectively define a path of motion. An assembly includes a first component configured to be attached to a first member of the anatomical joint; a second component configured to be attached to a second member of the anatomical joint; and a joint joining the first and second components. The first component includes a first flex member and the second component includes a second flex member. The first and second flex members are configured to flex to absorb energy transferred by the members of the anatomical joint.
US08679174B2 Catheter for the transvascular implantation of prosthetic heart valves
A catheter for the transvascular implantation of prosthetic heart valves, including self-expanding anchorage supports, which allow a minimally invasive implantation of prosthetic heart valves to reduce the risk to the patient during the implantation. A prosthetic heart valve including anchorage supports is temporarily housed in a folded form in a cartridge-type unit during the implantation. The cartridge-type unit can be fixed on the proximal end of a guide system, which includes a flexible region that can be guided through the aorta. Actuating elements run through the interior of the hollow guide system, permitting sections of the cartridge-type unit to be displaced radially about their longitudinal axis and/or laterally in a proximal direction, thus allowing individual sections of the anchorage support and the associated prosthetic heart valve to be sequentially released.
US08679173B2 Hybrid stent and method of making such a stent
A hybrid stent (100) includes at least one resilient ring (105) comprising a superelastic wire (102) formed in a sinusoidal pattern of alternating crests (110) and troughs (115) about a circumference of the ring (105). A plurality of malleable cannula segments (120) overlie the superelastic wire at the crests and troughs. Each of the cannula segments (120) includes a bend (125) and has an inner diameter sized to allow relative motion between the wire (102) and the cannula segment (120). The hybrid stent (100) may also include a plurality of gaps (130), where each gap (130) is defined by a spacing between opposing cannula segments (120). Deformation of the malleable cannula segments (120) dominates a response of the stent to substantially uniform radial forces, and deformation of the resilient ring (105) dominates a response of the stent to radially nonuniform crushing forces.
US08679172B2 Delivery device for delivering a stent device
A delivery device (12) for delivering a stent device (3) in a reduced profiled delivery configuration is provided. A distal region (9) of the stent device is axially anchored to an inner catheter (2) by annular rings (5, 6) about the inner catheter. A remaining portion (10) of the stent device is spaced radially from the inner catheter. A proximal stop (4) is spaced axially from a proximal end of the stent device. The stent device is maintained in the reduced profile delivery configuration by a retractable outer sheath (1).
US08679165B1 Cervical plate having graduated thickness
A cervical plate is disclosed. The plate includes plate body with a first end adapted for attachment to a first vertebra in a cephalad relation to the plate body and a second end adapted for attachment to second vertebra in a caudad relation to the plate body. The plate body being of a first thickness at the first end and of a second thickness at the second end, the first thickness being smaller than the second thickness, and the plate body transitioning from the first thickness to the second thickness in a graduated manner.
US08679164B2 Compliant osteosynthesis fixation plate
A bendable polymer tissue fixation device suitable to be implanted into a living body, comprising a highly porous body, the porous body comprising a polymer, the porous body comprising a plurality of pores, the porous body being capable of being smoothly bent, wherein the bending collapses a portion of the pores to form a radius curve, the polymer fixation device being rigid enough to protect a tissue from shifting. In a preferred embodiment the polymer fixation device may be capable of being gradually resorbed by said living body. In one embodiment, the polymer fixation device comprises a plurality of layers distinguishable by various characteristics, such as structural or chemical properties. In another embodiment, the polymer fixation device may comprise additional materials; the additional materials serving to reinforce or otherwise alter the structure or physical characteristics of the device, or alternatively as a method of delivering therapy or other agents to the system of a living being.
US08679162B2 Polyaxial bone anchors with increased angulation
A polyaxial bone anchor has a locking element shaped and configured to allow an anchoring member (e.g., a screw or hook) to polyaxially rotate at large angles about a central axis of the bone anchor before compression locking the anchoring member within an anchor head.
US08679160B2 Lamina implant set
An implant set for insertion into the lamina of a vertebra includes several reinforcing implants, each of which includes a main body with bearing surfaces on the vertebra and a fastening device. The main body has a front surface, a rear surface, and lateral and medial side surfaces, the medial side surface being offset rearwardly in relation to the lateral side surface. The side surfaces bear on sectioned surfaces of the lamina, and a rearwardly protruding extension with a lateral bearing surface on a spinous process of the vertebra is arranged on the rear surface. In this way, the resection opening can be easily and safely closed. Sleeves can be provided for the fastening via screws that are oriented such that the screws are guided through the adjoining facets and fuse the latter.
US08679151B2 Access device including shape memory deployment mechanism
A surgical access device is disclosed which includes a housing, a collar, and a plurality of deformable members. The housing defines a proximal end and a distal end and has a plurality of lumens extending therethrough. The collar is repositionable between a first position and a second position with the second position being closer to the proximal end of the housing than the first position. Each of the plurality of deformable members defines a distal portion, is coupled to the collar and is transitionable through one of the plurality of lumens. The plurality of deformable members is in a retracted state when the collar is in the first position and a deployed state when the collar is in the second position. One or more of the plurality of deformable members may also include a barb attached to the distal portion.
US08679149B2 Embolic protection device
The embolic protection device (10) has an expandable tubular structure supporting a filter mesh material (12). The embolic protection device is compressed to a small diameter for insertion into a patient's aorta, then expanded within the aorta with the filter mesh material positioned to allow blood to enter sidebranch vessels connected to the aorta and to prevent embolic material from entering the sidebranch vessels. The filter mesh material may be configured with waves or undulations (26) for increased surface area and/or with two layers of mesh material to provide additional protection against embolization and to prevent inadvertent occlusion of the sidebranch vessels.
US08679148B2 Distal protection device
A distal protection device comprising a catheter having a first strut movable from a collapsed configuration to an expanded configuration having a first dimension and a second strut movable from a collapsed configuration to an expanded configuration having a second dimension larger than the first dimension. Movement of the first strut deploys filter material to a first position having a first deployed dimension and movement of the second strut to a first position deploys filter material to a second deployed dimension larger than the first expanded dimension.
US08679147B2 Rectal balloon apparatus with pressure relieving lumen and sensors
A rectal balloon apparatus comprises a shaft having a fluid passageway extending therethrough. A rectal gas relieving lumen may be positioned with the shaft for removal of rectal gas. A motion detecting sensor and a radiation detecting sensor may be positioned with the balloon, the shaft, and/or the rectal gas release lumen.
US08679144B2 Puncture needle cartridge and puncture device
A puncture needle cartridge 20 detachably mounted on a puncturing device body to form a puncturing device is provided with a needle body 21 having a puncturing portion 212a, and also with a casing 22 for housing the needle body 21 and having openings 223, 224 that are respectively formed in front of and behind the needle body 21. The needle body 21 is mounted so as to be movable between a retracted position, wherein the tip 212c of the puncturing portion is retraced in the casing 22, and an extended position, wherein the tip 212c of the puncturing portion is projected outward from the casing 22 by receiving a pressing force from the puncturing device body. The needle body 21 has a biasing means for biasing the needle body 21 from an extended position towards a retracted position. The puncture needle cartridge can be mass-produced at low cost, and enables a user to perform puncturing safely and easily.
US08679142B2 Methods and apparatus for flow restoration
Methods for restoring blood flow in occluded blood vessels using an apparatus having a self expandable distal segment that is pre-formed to assume a superimposed structure in an unconstrained condition but can be made to take on a volume-reduced form making it possible to introduce it with a microcatheter and a push wire arranged at the proximal end, with the distal segment in its superimposed structure assuming the form of a longitudinally open tube and having a mesh structure of interconnected strings or filaments or struts. In a preferred embodiment, the distal segment has a tapering structure at its proximal end where the strings or filaments or struts converge at a connection point.
US08679132B2 Insertion system
An insertion system for inserting a sensor into fatty tissue, comprising an insertion device and an insertion needle containing a sensor, wherein the insertion device comprises a holder for the insertion needle, and a piercing mechanism so as to move the holder, with the needle held by the same, in a feed direction for a puncture. The piercing mechanism changes the feed direction during the puncture so that, at the end of the puncture, an insertion needle held by the holder is oriented obliquely or perpendicular to the initial feed direction. Also provided are methods for controlling a needle moved by an insertion device.
US08679131B2 Bone preparation reference guide
A reference guide comprising an attachment portion configured to abut with and attach to an anatomical feature such as a bone. The reference guide further comprises a reference indicator that may be formed integrally with, or selectively securable to, the attachment portion and that indicates a reference point with respect to the attachment portion. The reference guide may be used to identify a target location during a surgical procedure even in the absence of traditional landmarks.
US08679117B2 Bolt and tool with anti-torque features
A system for fixing a wire to a surface of an external fixator having a wire adapted to extend through bony structure fastened with respect to the surface. A bolt having a shaft which comprises a threaded section, a head section and at least one clamping element is provided wherein the bolt is adapted to extend through an opening in the external fixation element with a nut, and clamps the wire to the surface. A counter torque tool is used to provide a counter torque while fastening the wire with the bolt and the nut. The bolt comprises a counter torque opening and wherein the counter torque tool comprises a section which is adapted to engage into the counter torque opening of the bolt to apply the counter torque.
US08679110B2 Expandable vein ligator catheter having multiple electrode leads, and method
A catheter includes a plurality of primary leads to deliver energy for ligating a hollow anatomical structure. Each of the primary leads includes an electrode located at the working end of the catheter. Separation is maintained between the primary leads such that each primary lead can individually receive power of selected polarity. The primary leads are constructed to expand outwardly to place the electrodes into apposition with an anatomical structure. High frequency energy can be applied from the leads to create a heating effect in the surrounding tissue of the anatomical structure. The diameter of the hollow anatomical structure is reduced by the heating effect, and the electrodes of the primary leads are moved closer to one another. Where the hollow anatomical structure is a vein, energy is applied until the diameter of the vein is reduced to the point where the vein is occluded. In one embodiment, a secondary lead is surrounded by the primary leads, and extends beyond the primary leads. The secondary lead includes an electrode at the working end of the catheter. The secondary lead can have a polarity opposite to the polarity of the primary leads in a bipolar configuration. The polarity of the leads can be switched and the catheter can be moved during treatment to ligate an extended length of the vein. The catheter can include a lumen to accommodate a guide wire or to allow fluid delivery.
US08679107B2 Radiofrequency perforation apparatus
A radiofrequency perforation apparatus for creating a channel at a target location in a body of a patient, the radiofrequency perforation apparatus comprising: a substantially tubular member defining a tubular member lumen; an end member partially positioned within the tubular member lumen at a distal end of the tubular member, the end member including an electrode; and an electrical insulator extending along the substantially tubular member.
US08679103B2 Two step mammalian biofilm treatment processes and systems
A two-step mammalian biofilm treatment process can have a first step of disrupting or dispersing an undesired biofilm present at a treatment site in or on a mammalian host by suitable mechanical action for example, by applying irrigation fluid, sonic or other vibration, a mechanical instrument or laser-generated mechanical shockwaves to the biofilm. The treatment can also have a second step comprising applying an antimicrobial treatment to the mammalian host to control possible infection related to biofilm dispersed in the first step or to residual biofilm at the treatment site. Usefully, the second step can be performed within a limited time period after the first step. The process can also include additional steps The antimicrobial treatment can employ light or an antibiotic material. Included are implants cleaned of biofilm by a described process.
US08679102B2 Devices and methods for radiation-based dermatological treatments
A self-contained, hand-held device for providing a dermatological treatment includes a radiation source configured to generate one or more radiation beams, and an optical system configured to deliver the one or more radiation beams to the skin to provide a dermatological treatment. Each radiation beam includes a first axis beam profile and an orthogonal second axis beam profile. The optical system includes a first axis optic configured to influence the first axis beam profile of each radiation beam by a greater extent than the second axis beam profile of each radiation beam, and a second axis optic configured to influence the second axis beam profile of each radiation beam by a greater extent than the first axis beam profile of each radiation beam.
US08679099B2 Side looking minimally invasive surgery instrument assembly
A surgical instrument is inserted through a guide tube. The surgical instrument exits at an intermediate position of the guide tube and is oriented to be substantially parallel to the guide tube's longitudinal axis as it exits. A stereoscopic image capture component is on the guide tube between the intermediate position and the guide tube's distal end. The image capture component's field of view is generally perpendicular to the guide tube's longitudinal axis. The guide tube is jointed to allow the image capture component to be moved. The surgical instruments and the guide tube are telemanipulatively controlled.
US08679097B2 Method and devices for minimally invasive arthroscopic procedures
A surgical device is provided, the device having a tubular outer body member with a handle at its proximal end and a flexible distal end segment extending from its distal end. The surgical device also has an operable end extending from the distal end of the flexible distal end segment. The device is configured for selectively causing the flexible end segment to bend to adopt a desired curvature and for selectively rotating the operable end relative to the flexible distal end segment about an axis of the flexible distal end segment.
US08679096B2 Multifunctional operational component for robotic devices
The various embodiments disclosed herein relate to modular medical devices, including various devices with detachable modular components and various devices with pivotally attached modular components. Additional embodiments relate to procedures in which various of the devices are used cooperatively. Certain embodiments of the medical devices are robotic in vivo devices.
US08679095B2 Regulator
A flow regulator (19, 208, 308, 408) may be used in a drug delivery system 10. The regulator includes a chamber that is divided by a diaphragm (111, 211, 311, 411) into a first and second subchamber. A third subchamber is in fluid communication with the first subchamber. A valve (26, 217, 317, 417) is operatively connected to the diaphragm, wherein pressure differences between the first subchamber and second subchamber result in movement of the diaphragm and movement of the diaphragm controls operation of the valve. A flow restrictor (116, 216, 316, 416) is in fluid communication between the first and second subchambers. Flow of a drug (11, 101) is thereby regulated.
US08679092B2 Catheter assembly
A catheter assembly is provided. The catheter assembly includes a urinary catheter adapted for insertion into a urethra and a catheter package sized to receive the urinary catheter. The urinary catheter is configured to project from the catheter package to accommodate insertion into the urethra.
US08679091B2 Catheter
A catheter is provided that includes an elongated body extending from a proximal end to a distal end. The body defines at least one lumen. A tip has a proximal end that is disposed in abutting relation with the distal end of the body such that the body is fixed with the tip. The tip defines a lateral opening that is defined by a wall including an external radius disposed in transition with an outer surface of the tip and an internal radius disposed in transition with an inner surface of the tip. The external radius has a non-perpendicular profile with the outer surface of the tip.
US08679088B2 Cranial evacuation system and use thereof
The present invention relates to a method and device for removing solid matter from a brain and controlling bleeding associated with the removal of the matter. The method involves securing a cranial anchor to a region of the skull in which an opening has been created to expose brain matter and introducing through a passage defined by the anchor a channel member that displaces brain tissue and exposes the solid matter. After removing the solid matter, a flowable hemostat is introduced into the cavity created by removal of the matter. A balloon introduced into the working channel is then inflated to compress the hemostat against the wall of the cavity to control bleeding from blood vessels around the cavity. The device includes a cranial anchor, a channel member defining a working channel, an optional removable trocar, and a catheter for introducing the hemostat and the inflatable balloon into the cavity.
US08679087B2 Therapy delivery system having an open architecture and a method thereof
A therapy delivery system having an open architecture and method of providing thereof are disclosed. The present invention provides a therapy dosage module having a control algorithm that can be replaced with a predefined or independently defined control algorithm. The tools necessary to create and test such control algorithms in the therapy dosage module in a simulated environment before implementing it in a live therapy system are also disclosed.
US08679086B2 Airless intravenous bag
The present disclosure provides for an airless intravenous (IV) bag which contains a specialized device, referred to herein as the airless intravasculature infusion device (AIVID). The AIVID allows one to view the amount of fluid in the IV bag but substantially decreases or completely prohibits the risk of an inadvertent air infusion into a patient.
US08679085B2 Reusable diaper
The present invention relates to a reusable diaper shaped as a pair of pants and designed to house a removable absorbent insect (6). The diaper comprises an elongated central piece (5) impermeable to water and designed to house said insert, and two side pieces (12,13) arranged on opposite sides of the central piece, wherein at least one of the side pieces is made of a material permeable to water and is arranged stretchable to allow stretching of waist and leg openings of the diaper when the diaper is put on and taken off, and the central piece and the side piece are joined together by means of a joint (15,16) forming a liquid barrier.
US08679084B2 Absorbent article
In a three-dimensional gather BS, a sheet extending from the lateral side to the center side direction is folded in four by folding the sheet at the first folding portion folded back toward the lateral side on a central side position and at the second folding portion and the third folding portion in series to form the first folding back surface, the second folding back surface, the third folding back surface, and the fourth folding back surface. In a predetermined range containing the body fluid excretion portion, at least the third folding back surface and the fourth folding back surface stand so as to form an approximately dogleg-shaped cross section, and in the buttock side portion, the second folding back surface to the fourth folding back surface are bonded to one another, and stand linearly in an oblique manner toward the outer side direction.
US08679083B2 Reusable breast shield
A reusable, washable breast shield for use by lactating women. The shield may include an inner layer and an outer layer. The shield may be placed against the breast of the user and may be held in place with an article of clothing or may be used without supporting clothing.
US08679080B2 Dressing assemblies for wound treatment using reduced pressure
A dressing assembly for use with a reduced pressure treatment system, the dressing assembly develops a directed force under reduced pressure. The directed force may be a radial force or a closing force. The dressing assembly includes a shaped dressing bolster having a shaped extremity that is operable to evenly deliver the radial force and to distribute reduced pressure. Numerous shapes may be used for the shaped extremity. The dressing assembly may further include an over-drape to assist in creating a seal over the shaped dressing bolster and against a portion of a patient's epidermis.
US08679077B2 System and method for delivering moisturizing liquid to lips of a subject
A system for delivering moisturizing liquid to the lips of a subject includes an applicator for applying the moisturizing liquid to the lips supported by a support structure so that at least a part of applicator is deployed so as to engage a recess between the lips of subject without obstructing contact between the subject's upper and lower lips. The proximity of the applicator to the lips allows the use of simple contact-based implementations of the applicator. At the same time, disruption of speech and other normal oral movement is minimized by avoiding any obstruction to contact between the lips.
US08679074B2 Pressure responsive slit valve assembly for a plurality of fluids and uses thereof
A pressure responsive slit valve assembly is designed to be used in a variety of configurations of medical devices to manage contemporaneous and pressure responsive fluid communications between such devices and a plurality of fluid sources. The pressure responsive slit valve assembly of the present invention includes a valve housing adapted to receive fluids from at least two sources and a pressure responsive slit valve means corresponding to each fluid sources.
US08679071B2 Injection device comprising a mechanical lock
An injection device with a housing and an operating element or coupling element mounted in the housing in such a way that the operating element or coupling element may be retained in a first position by a first holding connection and may be displaced into a second position that is axially offset relative to the first position after introducing an ampoule. In some embodiments, the operating element or coupling element may be retained by a second holding connection in the second position.
US08679070B2 Modular administration system
A modular administration appliance including a reusable base unit and a replaceable cartridge detachably connected to the base unit and including a container for a substance and a rotatable transmission element, the base unit including a drive device by which a rotary movement is transmitted between the base unit and the cartridge, and a driving element displaceable in a rotary movement about a rotational axis by the drive device, wherein a rotation of the transmission element causes the ejection of at least a portion of the substance from the container. In some embodiments, the transmission element at least partially surrounds the drive device, and/or the drive element and the transmission element are detachably connectable to each other for transmitting the rotational movement.
US08679067B2 Medical tubing securement assembly and methods of use
A medical tubing securement assembly includes a base having a disc, and a retaining adapter removably and rotatably attached to the disc. The retaining adapter includes a longitudinal passage for receiving a locking adapter. The locking adapter includes a longitudinal passage for receiving a medical tube. Once the tube is inserted into the locking adapter, the locking adapter may be rotated within the retaining adapter, around the tube, to secure the tube within the securement assembly.
US08679064B2 Ophthalmic valved trocar cannula
In various embodiments, a trocar cannula may be configured for insertion into an eye to facilitate insertion and removal of instruments during surgery. The cannula may be affixed to an overcap (to inhibit rotation of the overcap relative to the cannula) that includes a seal. In some embodiments, the seal may be overmolded into the overcap or may include a wafer that is fixed between the cannula and the overcap to inhibit rotation relative to the cannula and the overcap. In some embodiments, the cannula and overcap may snap together through a tab/slot interface in a permanent fashion such that the cannula and overcap may not be separated without damaging the cannula or overcap. In some embodiments, a vent cannula may be receivable in the slit of the seal for allowing fluids to vent from the eye through the cannula (which may include an indentation to frictionally engage the vent).
US08679063B2 Systems and methods for providing a catheter assembly
A system for controlling fluid flow in a catheter assembly is disclosed herein. An intravenous catheter assembly has a catheter adapter and a needle hub, and the catheter adapter has an inner lumen. A septum is disposed within a portion of the inner lumen, and a slit is formed through the septum. A Parylene coating is disposed within the slit of the septum, the Parylene coating has a thickness of between approximately 0.00005 to 0.0005 millimeters. An introducer needle has a first end coupled to the needle hub and the second end extending through the inner lumen of the catheter adapter. A middle portion of the introducer needle is positioned within a portion of the septum.
US08679061B2 Automatic injection device
An automatic injection device for providing a subcutaneous injection is disclosed. The device includes a syringe movably disposed in a housing and including a barrel portion, a needle and a bung for sealing the barrel portion. The device includes a plunger for moving the syringe towards a first open end of the housing such that the needle projects from the first end and subsequently applying pressure to the bung. The plunger includes a rod connected at a first end to the bung, a compressible expanded central portion, and a flange between a second end of the rod and the central portion. The device includes a biasing mechanism for biasing the plunger towards the first open end of the housing, the biasing mechanism disposed about the second end of the rod between the flange and the second end of the housing.
US08679059B2 Immobilizing objects in the body
Stabilizing an object in the body of a patient involves the injection of a lower critical solution temperature (LCST) material or other flowable material into the body of the patient so that the material contacts the object. The LCST material or other flowable material then forms a gel in the body such that the object is contained at least partially within the gel and thereby stabilized by the gel such that the object can then be easily fragmented within the body and/or retrieved from the body.
US08679049B2 Device and method for vascular re-entry
In a method for re-entry from extraluminal space into the central lumen of a vessel, a guidewire is advanced into the extraluminal space of the vessel, and then a directional catheter is advanced over the guidewire through the extraluminal space. Thereafter, the guidewire is removed from the directional catheter, an ultrasound device is placed through the directional catheter, and the ultrasound device is advanced through the extraluminal space into the central lumen and then activated.
US08679048B2 Optimization of hydrocephalus shunt settings
A method is described for using a postoperative CSF dynamical examination to determine the CSF dynamical state of the patient and the dynamical state of the CSF shunt in conjunction therewith.